title: Effect of GGCX gene polymorphism on the responses of serum undercarboxylated osteocalcin and bone turnover markers after treatment with vitamin K2 (menatetrenone) among postmenopausal Thai women.
abstract: The purpose of this study was to evaluate the influence of gamma-glutamyl transferase (GGCX) gene polymorphisms on the response of serum undercarboxylated osteocalcin (ucOC) and bone turnover markers 3 months after treatment with menatetrenone. One hundred and forty postmenopausal Thai women were enrolled and assigned to receive 45 mg/day treatment of menatetrenone (MK-4) concurrently with calcium 1.2 g and vitamin D 400 IU for 3 months. Demographic characteristics, GGCX genotyping, serum bone turnover markers and ucOC levels were obtained from all participants at baseline. We evaluated the reduction of ucOC at 3 months and the reduction of beta-CTx and P1NP at 1 and 3 months. The responses were compared between the different genotypes of GG and GA + AA groups. There was a significant reduction of serum ucOC, beta-CTx and P1NP from the baseline at 3 months (p < 0.001) though there was no significant difference between genotypes (GG vs. GA + AA; p > 0.05). Nonetheless, a subgroup analysis of postmenopausal women who 65 years of age or over (N = 37) revealed a significant difference between the two groups in the reduction of ucOC. Menatetrenone significantly reduced serum ucOC as well as beta-CTX and P1NP from the baseline. GGCX polymorphism appeared to have an influence over the reduction of ucOC especially in older women (age ≥65). Furthermore, the groups which have "A" allele trend to being more efficient in reducing the serum ucOC level than the group which does not have it.
authors.affiliation: Department of Orthopaedics, Phramongkutklao Hospital and College of Medicine, Rajthevee, Bangkok, Thailand. thaweesps@yahoo.com
authors.forename: Thawee
authors.initials: T
authors.lastname: Songpatanasilp
authors.forename: La-or
authors.initials: LO
authors.lastname: Chailurkit
authors.forename: Suwannee
authors.initials: S
authors.lastname: Chantprasertyothin
authors.forename: Boonsong
authors.initials: B
authors.lastname: Ongphiphadhanakul
authors.forename: Nimit
authors.initials: N
authors.lastname: Taechakraichana
mesh_terms: D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D011110:Polymorphism, Genetic / Q000235:genetics; D017698:Postmenopause / Q000097:blood / Q000235:genetics; D013785:Thailand; D024482:Vitamin K 2 / Q000031:analogs & derivatives / Q000494:pharmacology*; D005723:gamma-Glutamyltransferase / Q000235:genetics*
chemical_list: D015675:Osteocalcin; D024482:Vitamin K 2; C030814:menatetrenone; D005723:gamma-Glutamyltransferase