title: Genomic evolution in domestic cattle: ancestral haplotypes and healthy beef.
abstract: We have identified numerous Ancestral Haplotypes encoding a 14-Mb region of Bota C19. Three are frequent in Simmental, Angus and Wagyu and have been conserved since common progenitor populations. Others are more relevant to the differences between these 3 breeds including fat content and distribution in muscle. SREBF1 and Growth Hormone, which have been implicated in the production of healthy beef, are included within these haplotypes. However, we conclude that alleles at these 2 loci are less important than other sequences within the haplotypes. Identification of breeds and hybrids is improved by using haplotypes rather than individual alleles.
authors.affiliation: C.Y. O'Connor ERADE Village Foundation, Canning Vale, Western Australia, Australia.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Williamson
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Steele
authors.forename: Susan
authors.initials: S
authors.lastname: Lester
authors.forename: Oscar
authors.initials: O
authors.lastname: Kalai
authors.forename: John A
authors.initials: JA
authors.lastname: Millman
authors.forename: Lindsay
authors.initials: L
authors.lastname: Wolrige
authors.forename: Dominic
authors.initials: D
authors.lastname: Bayard
authors.forename: Craig
authors.initials: C
authors.lastname: McLure
authors.forename: Roger L
authors.initials: RL
authors.lastname: Dawkins
mesh_terms: D000483:Alleles; D000818:Animals; D005075:Biological Evolution; D001947:Breeding; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D005787:Gene Frequency; D016678:Genome; D013006:Growth Hormone / Q000235:genetics*; D006239:Haplotypes; D008460:Meat / Q000592:standards; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics*
chemical_list: D051780:Sterol Regulatory Element Binding Protein 1; D013006:Growth Hormone