title: Novel carbon-carbon bond formations for biocatalysis.
abstract: Carbon-carbon bond formation is the key transformation in organic synthesis to set up the carbon backbone of organic molecules. However, only a limited number of enzymatic C-C bond forming reactions have been applied in biocatalytic organic synthesis. Recently, further name reactions have been accomplished for the first time employing enzymes on a preparative scale, for instance the Stetter and Pictet-Spengler reaction or oxidative C-C bond formation. Furthermore, novel enzymatic C-C bond forming reactions have been identified like benzylation of aromatics, intermolecular Diels-Alder or reductive coupling of carbon monoxide.
authors.affiliation: Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
authors.forename: Verena
authors.initials: V
authors.lastname: Resch
authors.forename: Joerg H
authors.initials: JH
authors.lastname: Schrittwieser
authors.forename: Elina
authors.initials: E
authors.lastname: Siirola
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kroutil
mesh_terms: D055162:Biocatalysis; D002244:Carbon / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D004798:Enzymes / Q000378:metabolism; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D004798:Enzymes; D002244:Carbon