title: Environmental chemical mediated male reproductive toxicity: Drosophila melanogaster as an alternate animal model.
abstract: Industrialization and indiscriminate use of agrochemicals have increased the human health risk. Recent epidemiological studies raised a concern for male reproduction given their observations of reduced sperm counts and altered semen quality. Interestingly, environmental factors that include various metals, pesticides and their metabolites have been causally linked to such adversities by their presence in the semen at levels that correlate to infertility. The epidemiological observations were further supported by studies in animal models involving various chemicals. Therefore, in this review, we focused on male reproductive toxicity and the adverse effects of different environmental chemicals on male reproduction. However, it is beyond the scope of this review to provide a detailed appraisal of all of the environmental chemicals that have been associated with reproductive toxicity in animals. Here, we provided the evidence for reproductive adversities of some commonly encountered chemicals (pesticides/metals) in the environment. In view of the recent thrust for an alternate to animal models in research, we subsequently discussed the contributions of Drosophila melanogaster as an alternate animal model for quick screening of toxicants for their reproductive toxicity potential. Finally, we emphasized the genetic and molecular tools offered by Drosophila for understanding the mechanisms underlying the male reproductive toxicity.
authors.affiliation: Embryotoxicology Division, Indian Institute of Toxicology Research, M.G. Marg, Lucknow-226001, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Tiwari
authors.forename: P
authors.initials: P
authors.lastname: Pragya
authors.forename: K
authors.initials: K
authors.lastname: Ravi Ram
authors.forename: D Kar
authors.initials: DK
authors.lastname: Chowdhuri
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D020869:Gene Expression Profiling; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D019216:Metals, Heavy / Q000633:toxicity; D023421:Models, Animal; D009152:Mutagenicity Tests; D010575:Pesticides / Q000633:toxicity; D012098:Reproduction / Q000187:drug effects* / Q000235:genetics; D012661:Semen / Q000737:chemistry
chemical_list: D004785:Environmental Pollutants; D019216:Metals, Heavy; D010575:Pesticides