title: Architecture of the Helicobacter pylori Cag-type IV secretion system.
abstract: Type IV secretion systems (T4SS) are macromolecular assemblies used by bacteria to transport material across their membranes. T4SS are generally composed of a set of twelve proteins (VirB1-11 and VirD4). This represents a dynamic machine powered by three ATPases. T4SS are widespread in pathogenic bacteria where they are often used to deliver effectors into host cells. For example, the human pathogen Helicobacter pylori encodes a T4SS, the Cag-T4SS, which mediates the injection of the toxin CagA. We review the progress made in the past decade in our understanding of T4SS architecture. We translate this new knowledge to derive an understanding of the structure of the H. pylori Cag system, and use recent protein-protein interaction data to refine this model.
authors.affiliation: Institut de Biologie et Chimie des Protéines, Biologie Structurale des Complexes Macromoléculaires Bactériens, UMR 5086 CNRS Université de Lyon, Lyon, France. laurent.terradot@ibcp.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Terradot
authors.forename: Gabriel
authors.initials: G
authors.lastname: Waksman
mesh_terms: D000942:Antigens, Bacterial / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000737:chemistry; D029968:Escherichia coli Proteins / Q000737:chemistry; D010861:Fimbriae, Bacterial / Q000502:physiology; D016480:Helicobacter pylori / Q000737:chemistry* / Q000472:pathogenicity; D046912:Multiprotein Complexes / Q000737:chemistry*; D043583:Nucleoside-Triphosphatase / Q000737:chemistry; D021381:Protein Transport / Q000502:physiology
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D046912:Multiprotein Complexes; C103937:PicB protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori; C403125:trwB protein, E coli; D043583:Nucleoside-Triphosphatase