title: Tin (IV) chloride-promoted one-pot synthesis of novel tacrine analogues.
abstract: A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, ¹H- and ¹³C-NMR.
authors.affiliation: College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China. hhn12192000@yahoo.com.cn
authors.forename: Huanan
authors.initials: H
authors.lastname: Hu
authors.forename: Liangfu
authors.initials: L
authors.lastname: Song
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Fang
authors.forename: Junjun
authors.initials: J
authors.lastname: Zheng
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Meng
authors.forename: Yiting
authors.initials: Y
authors.lastname: Luo
mesh_terms: D004952:Esters / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D011720:Pyrazoles / Q000737:chemistry; D013619:Tacrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry*
chemical_list: D004952:Esters; D009570:Nitriles; D011720:Pyrazoles; D017971:Tin Compounds; C023599:stannous chloride; D013619:Tacrine