title: Pharmacoeconomics of darunavir.
abstract: Darunavir boosted with ritonavir (DRV/r) in combination with other antiretrovirals (ARVs) was initially approved in 2006 for the treatment of HIV infection in ARV treatment-experienced adults and has subsequently been approved for use in treatment-naive adults in 2008. Clinical studies have shown that DRV/r in combination with other ARVs achieves superior levels of undetectable plasma HIV RNA and generates significant CD4 increases, which reduce the risk of HIV disease progression. Economic evaluations, based on data from controlled clinical trials, found DRV/r combination therapy to generate savings in hospital costs and other non-ARV costs of care in treatment-experienced patients, to maximize the number of patients reaching undetectable plasma HIV RNA, to improve health-related quality of life and quality-adjusted life expectancy, and to be cost effective across different patient populations.
authors.affiliation: Strategic Pharmacy Innovations, 4910 Purdue Ave NE, Seattle, WA 98105, USA. peteful@msn.com
authors.forename: Dwight S
authors.initials: DS
authors.lastname: Fullerton
authors.forename: Erik
authors.initials: E
authors.lastname: Smets
authors.forename: Guy
authors.initials: G
authors.lastname: De La Rosa
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Mrus
mesh_terms: D003362:Cost-Benefit Analysis; D000069454:Darunavir; D018450:Disease Progression; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000191:economics; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000191:economics* / Q000627:therapeutic use; D006801:Humans; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D019438:Ritonavir / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use; D013449:Sulfonamides / Q000008:administration & dosage / Q000191:economics* / Q000627:therapeutic use
chemical_list: D017320:HIV Protease Inhibitors; D013449:Sulfonamides; D019438:Ritonavir; D000069454:Darunavir