title: Targets for preventing epilepsy following cortical injury.
abstract: Prophylaxis of posttraumatic epilepsy will require a detailed knowledge of the epileptogenic pathophysiological processes that follow brain injury. Results from studies of experimental models and human epilepsy highlight alterations in GABAergic interneurons and formation of excessive new excitatory synaptic connectivity as prominent targets for prophylactic therapies. Promising laboratory results suggest that it will be possible to experimentally modify these aberrant processes and interfere with epileptogenesis. However, a number of key issues must be addressed before these results can be used to frame clinical antiepileptogenic therapy.
authors.affiliation: Epilepsy Research Laboratory, Department of Neurology and Neurological Sciences, Stanford University Sch. of Medicine, 300 Pasteur Dr., Stanford, CA 94305, United States.
authors.forename: Huifang
authors.initials: H
authors.lastname: Li
authors.forename: Whitney
authors.initials: W
authors.lastname: McDonald
authors.forename: Isabel
authors.initials: I
authors.lastname: Parada
authors.forename: Leonardo
authors.initials: L
authors.lastname: Faria
authors.forename: Kevin
authors.initials: K
authors.lastname: Graber
authors.forename: D Koji
authors.initials: DK
authors.lastname: Takahashi
authors.forename: Yunyong
authors.initials: Y
authors.lastname: Ma
authors.forename: David
authors.initials: D
authors.lastname: Prince
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*; D006801:Humans; D051381:Rats
chemical_list: D000927:Anticonvulsants