title: Plasma nitric oxide and left ventricular function in rabbits after cardiac lymphatic obstruction.
abstract: This study was designed to investigate the effect of cardiac lymphatic obstruction on plasma nitric oxide (NO) and left ventricular function. The plasma NO was measured in study group (n = 21) and control group rabbits (n = 12) before, and 3, 7, 14, 30 and 90 days after the obstruction of cardiac lymphatic vessels. Left ventricular ejection fraction was measured with echocardiography. There was a significant reduction in the left ventricular ejection fraction following the lymphatic obstruction (0.72±0.02 vs. 0.61±0.02, p<0.01). Plasma NO in the control group remained unchanged during the observation period (54.2±4.4 vs. 52.0±4.2 μmol/L, p>0.05). In the study group, there was a small but significant increase in the plasma NO on day 3, 7 and 14 following the lymphatic obstruction (52.3±4.1 vs. 73.4±5.9 μmol/L, p<0.01). The plasma NO returned to the baseline levels on day 30 but reduced to 44.9±3.6 μmol/L on 90 days after the lymphatic obstruction (p<0.05). In conclusion, cardiac lymphatic obstruction was associated with a significant reduction in left ventricular function. It was also associated with an increase in the plasma NO in the first 2 weeks but there was a significant reduction in the NO levels three months after the lymphatic obstruction.
authors.affiliation: Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, Department of Cardiology, Liaocheng, Shandong Province, PR China.
authors.forename: Ying-Li
authors.initials: YL
authors.lastname: Wang
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Wang
authors.forename: Ye
authors.initials: Y
authors.lastname: Jin
authors.forename: De-Gui
authors.initials: DG
authors.lastname: Kong
authors.forename: Le-Xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004452:Echocardiography; D005260:Female; D008206:Lymphatic Diseases / Q000097:blood* / Q000503:physiopathology*; D042601:Lymphatic Vessels / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D011817:Rabbits; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*
chemical_list: D009569:Nitric Oxide