title: Haemostatic system in inflammatory bowel diseases: new players in gut inflammation.
abstract: Inflammation and coagulation constantly influence each other and are constantly in balance. Emerging evidence supports this statement in acute inflammatory diseases, such as sepsis, but it also seems to be very important in chronic inflammatory settings, such as inflammatory bowel disease (IBD). Patients with Crohn's disease and ulcerative colitis have an increased risk of thromboembolic events, and several abnormalities concerning coagulation components occur in the endothelial cells of intestinal vessels, where most severe inflammatory abnormalities occur. The aims of this review are to update and classify the type of coagulation system abnormalities in IBD, and analyze the strict and delicate balance between coagulation and inflammation at the mucosal level. Recent studies on possible therapeutic applications arising from investigations on coagulation abnormalities associated with IBD pathogenesis will also be briefly presented and critically reviewed.
authors.affiliation: Department of Internal Medicine and Medical Specialties, Gastroenterology Division, Catholic University of Rome, 00168 Rome, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Scaldaferri
authors.forename: Stefano
authors.initials: S
authors.lastname: Lancellotti
authors.forename: Marco
authors.initials: M
authors.lastname: Pizzoferrato
authors.forename: Raimondo
authors.initials: R
authors.lastname: De Cristofaro
mesh_terms: D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000473:pathology* / Q000503:physiopathology*; D006487:Hemostasis; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000473:pathology; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000473:pathology / Q000503:physiopathology*; D013917:Thrombin / Q000378:metabolism
chemical_list: D013917:Thrombin