title: Plaque inhibitory effect of a 0.05% cetyl-pyridinium chloride mouth-rinse in a 4-day non-brushing model.
abstract: OBJECTIVE
  Results from clinical studies evaluating the efficacy of the adjunctive use of cetyl-pyridinium chloride (CPC) containing oral hygiene products have shown wide variability, probably due to differences in formulations. The objective of this study was to determine the inhibitory plaque effect of a 0.05% CPC mouth rinse in de novo plaque formation in a 4-day non-brushing experimental model.
  
  
  METHODS
  The study was designed as a short-term double-blind randomized cross-over experimental model aimed to compare three products: a negative control (similar to the test product, without active ingredients), a positive control (with 0.12% chlorhexidine and CPC) and the test product (with 0.05% CPC) in terms of plaque index, gingival inflammation and microbiological variables.
  
  
  RESULTS
  Plaque levels after 4 days were 2.88 for the positive control, 3.86 for the negative control and 3.60 for the test. Differences among groups on day 4 were statistically significant (P < 0.001). Gingival index showed comparable values at baseline (P = 0.745), and significant increases were observed, with the exception of the positive control. Total colony forming units showed comparable values at baseline (P = 0.125) and significant increases were observed only in the negative control.
  
  
  CONCLUSIONS
  The tested 0.05% CPC mouth-rinse is capable of inhibiting plaque formation.
authors.affiliation: Faculty of Odontology, University Complutense, Madrid, Spain.
authors.forename: V
authors.initials: V
authors.lastname: García
authors.forename: M
authors.initials: M
authors.lastname: Rioboo
authors.forename: J
authors.initials: J
authors.lastname: Serrano
authors.forename: A
authors.initials: A
authors.lastname: O'Connor
authors.forename: D
authors.initials: D
authors.lastname: Herrera
authors.forename: M
authors.initials: M
authors.lastname: Sanz
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001421:Bacteria, Anaerobic / Q000254:growth & development / Q000302:isolation & purification; D002594:Cetylpyridinium / Q000008:administration & dosage*; D015169:Colony Count, Microbial; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005891:Gingivitis / Q000517:prevention & control; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D010205:Pantothenic Acid / Q000008:administration & dosage; D010518:Periodontitis / Q000517:prevention & control; D014099:Toothbrushing; D014468:Umbelliferones / Q000008:administration & dosage; D055815:Young Adult; D017967:Zinc Compounds / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D009067:Mouthwashes; D014468:Umbelliferones; D017967:Zinc Compounds; D010205:Pantothenic Acid; D002594:Cetylpyridinium; C073110:permethol