title: Granzymes A and B levels in serum of patients with amyotrophic lateral sclerosis.
abstract: OBJECTIVE
  There are evidences that immuno-inflammatory mechanisms and apoptosis may play a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). It is known that Granzyme A (GzmA) and granzyme B (GzmB) are implicated in these mechanisms. The aim of the study was to investigate serum GzmA and GzmB levels in patients with ALS.
  
  
  METHODS
  The study included 30 patients with ALS and 30 patients from the control group. Serum GzmA and GzmB levels were measured using the enzyme-linked immunosorbent method.
  
  
  RESULTS
  The study showed that GzmA and GzmB levels are significantly increased in serum of patients with ALS when compared to the control group (p<0.05). There was a significant correlation of serum GzmB levels with severity of clinical state of ALS patients (p<0.05).
  
  
  CONCLUSIONS
  The results indicate that GzmA and GzmB are implicated in mechanisms of neurodegeneration in ALS.
authors.affiliation: Department of Neurological Rehabilitation, Medical University, ul. Chodźki 6, 20–953 Lublin, Poland. ilzecka@onet.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Iłżecka
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood* / Q000201:enzymology*; D005260:Female; D053804:Granzymes / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D053804:Granzymes