title: Healing activity induced by Cramoll 1,4 lectin in healthy and immunocompromised mice.
abstract: Cramoll 1,4 is a lectin extracted from seeds of Cratylia mollis Mart. Many assays have shown the cytokine release activity and pro-inflammatory profile of this lectin. Here, we used Cramoll 1,4 in the treatment of cutaneous wounds in normal and immunocompromised mice for available your cicatricial power. Surgical wounds were treated daily with a topical administration of Cramoll 1,4 and parameters as edema, hyperemia, scab, granulation and scar tissues as well as contraction of wounds were analyzed. Cramoll 1,4 wounds showed higher edema and arrival of more polimorphonuclear cells at the site of lesions. Granulation tissue and collagen fiber deposition were observed with higher intensity in all Cramoll 1,4 treated wounds and promoted excellent closing and repair of lesions in less time than other groups. Results showed that Cramoll 1,4 lectin was effective in the repair of experimental lesions in mice and can be used as a future cicatricial compound.
authors.affiliation: Centro de Pesquisas Aggeu Magalhães - CPqAM/FIOCRUZ, Pernambuco, Brazil. crismout melo@hotmail.com
authors.forename: Cristiane Moutinho Lagos
authors.initials: CM
authors.lastname: de Melo
authors.forename: Camila Souza
authors.initials: CS
authors.lastname: Porto
authors.forename: Mário Ribeiro
authors.initials: MR
authors.lastname: Melo-Júnior
authors.forename: Chirleanny Maciel
authors.initials: CM
authors.lastname: Mendes
authors.forename: Carmelita C Bezerra
authors.initials: CC
authors.lastname: Cavalcanti
authors.forename: Luana Cassandra Breitenbach Barroso
authors.initials: LC
authors.lastname: Coelho
authors.forename: Ana Lúcia Figueiredo
authors.initials: AL
authors.lastname: Porto
authors.forename: Ana Maria dos Anjos Carneiro
authors.initials: AM
authors.lastname: Leão
authors.forename: Maria Tereza dos Santos
authors.initials: MT
authors.lastname: Correia
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007887:Fabaceae / Q000737:chemistry; D005260:Female; D016867:Immunocompromised Host; D051379:Mice; D020556:Neutrophil Infiltration / Q000187:drug effects / Q000276:immunology; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D037121:Plant Lectins / Q000302:isolation & purification / Q000627:therapeutic use*; D012639:Seeds / Q000737:chemistry; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000293:injuries / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects* / Q000276:immunology*; D014950:Wounds, Penetrating / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D037121:Plant Lectins