title: Reverse micelle-loaded lipid nanocarriers: a novel drug delivery system for the sustained release of doxorubicin hydrochloride.
abstract: In this study, we are pioneering new nanotechnology for the encapsulation of anticancer drugs (doxorubicin (DOX) and/or docetaxel (DOCE)), whatever their solubility and water affinity. The purpose of this study is to highlight the potential of this recently patented technology, by carrying out a thorough physicochemical characterisation of these multiscaled nanocarriers, followed by the study of an encapsulation and release model of hydrophilic anticancer drug. The formulation process is based on a low-energy nano-emulsification method and allows the generation of a structure composed of oil-based nanocarriers loaded with reverse micelles. Thanks to this, hydrophilic contents can be solubilised in the oily core of this kind of nano-emulsion along with lipophilic content. The results emphasise some original structure particularities due to the multistep formulation process, and the diffusion-based behaviour revealed for the DOX release profile that is shown to be intimately linked to the morphology of the particles.
authors.affiliation: University of Angers, Inserm U646, Angers, France.
authors.forename: Sandy
authors.initials: S
authors.lastname: Vrignaud
authors.forename: Nicolas
authors.initials: N
authors.lastname: Anton
authors.forename: Pascal
authors.initials: P
authors.lastname: Gayet
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Benoit
authors.forename: Patrick
authors.initials: P
authors.lastname: Saulnier
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D004317:Doxorubicin / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D005079:Excipients / Q000737:chemistry; D005612:Freeze Drying; D008055:Lipids / Q000737:chemistry; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D014280:Triglycerides / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D005079:Excipients; D008055:Lipids; D008823:Micelles; D011108:Polymers; D014280:Triglycerides; C542236:labrafac WL 1349; D004317:Doxorubicin