title: Brilliant blue G-assisted peeling of the internal limiting membrane in macular hole surgery.
abstract: Dye-assisted internal limiting membrane (ILM) peeling and gas tamponade is the surgery of choice for idiopathic macular holes. Indocyanine green and trypan blue have been extensively used to stain the ILM. However, the retinal toxicity of indocyanine green and non-uniform staining with trypan blue has necessitated development of newer vital dyes. Brilliant blue G has recently been introduced as one such dye with adequate ILM staining and no reported retinal toxicity. We performed a 23-gauge pars plana vitrectomy with brilliant blue G-assisted ILM peeling in six patients with idiopathic macular holes, to assess the staining characteristics and short-term adverse effects of this dye. Adequate staining assisted in the complete removal of ILM and closure of macular holes in all cases. There was no evidence of intraoperative or postoperative dye-related toxicity. Brilliant blue G appears to be safe dye for ILM staining in macular hole surgery.
authors.affiliation: Department of Vitreoretina and Uvea Services, Dr. R. P. Center for Ophthalmic Sciences, AIIMS, New Delhi, India. drprashantnaithani@yahoo.co.in
authors.forename: Prashant
authors.initials: P
authors.lastname: Naithani
authors.forename: Naginder
authors.initials: N
authors.lastname: Vashisht
authors.forename: Sumeet
authors.initials: S
authors.lastname: Khanduja
authors.forename: Subijay
authors.initials: S
authors.lastname: Sinha
authors.forename: Satpal
authors.initials: S
authors.lastname: Garg
mesh_terms: D000368:Aged; D001557:Benzenesulfonates / Q000009:adverse effects; D004396:Coloring Agents / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D019773:Epiretinal Membrane / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012167:Retinal Perforations / Q000601:surgery*; D013194:Staining and Labeling / Q000379:methods; D014821:Vitrectomy / Q000379:methods
chemical_list: D001557:Benzenesulfonates; D004396:Coloring Agents; C006796:brilliant blue