title: Three dimensional projection environment for molecular design and surgical simulation.
abstract: We are developing agents for positron emission tomography (PET) imaging of cancer gene mRNA expression and software to fuse mRNA PET images with anatomical computerized tomography (CT) images to enable volumetric (3D) haptic (touch-and-feel) simulation of pancreatic cancer and surrounding organs prior to surgery in a particular patient. We have identified a novel ligand specific for epidermal growth factor receptor (EGFR) to direct PET agent uptake specifically into cancer cells, and created a volumetric haptic surgical simulation of human pancreatic cancer reconstructed from patient CT data. Young's modulus and the Poisson ratio for each tissue will be adjusted to fit the experience of participating surgeons.
authors.affiliation: Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Wickstrom
authors.forename: Chang-Po
authors.initials: CP
authors.lastname: Chen
authors.forename: Devakumar
authors.initials: D
authors.lastname: Devadhas
authors.forename: Matthew
authors.initials: M
authors.lastname: Wampole
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Jin
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Sanders
authors.forename: John C
authors.initials: JC
authors.lastname: Kairys
authors.forename: Martha L
authors.initials: ML
authors.lastname: Ankeny
authors.forename: Rui
authors.initials: R
authors.lastname: Hu
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Barner
authors.forename: Karl V
authors.initials: KV
authors.lastname: Steiner
authors.forename: Mathew L
authors.initials: ML
authors.lastname: Thakur
mesh_terms: D003198:Computer Simulation; D015195:Drug Design; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008954:Models, Biological; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014584:User-Computer Interface
chemical_list: D019275:Radiopharmaceuticals