title: Adults requiring cord blood transplants but have insufficient cell doses from a single cord blood unit can receive two units with successful engraftment kinetics similar to those of children receiving a single unit.
abstract: We retrospectively evaluated neutrophil engraftment kinetics in 29 single versus nine double unit cord blood transplants (CBTs). All single CBTs were performed in pediatric patients (non-malignant/malignant diseases, 19/10), while all double CBTs were performed in adults (n = 8) and an adolescent (n = 1) with hematological malignancies. Median follow-up time was 2.3 years (range, 0.1-13.5 years). Engraftment was achieved in 69% and 89% of the single and double cord blood (CB) groups, respectively. Similarly, median day of engraftment was not different for the single versus the double CBTs, at 19 and 23 days, respectively, and the neutrophil engraftment kinetics was similar in the two groups. Our data indicate that adults without sufficient nucleated cell doses in a single CB unit may receive two units with similar engraftment kinetics to those of children receiving only a single unit.
authors.affiliation: Pediatric Hemato-oncology and Bone Marrow Transplantation Department, The Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel. gal.goldstein@sheba.health.gov.il
authors.forename: Gal
authors.initials: G
authors.lastname: Goldstein
authors.forename: Ronit
authors.initials: R
authors.lastname: Elhasid
authors.forename: Bella
authors.initials: B
authors.lastname: Bielorai
authors.forename: Avichai
authors.initials: A
authors.lastname: Shimoni
authors.forename: Ronit
authors.initials: R
authors.lastname: Yerushalmi
authors.forename: Imad
authors.initials: I
authors.lastname: Kassis
authors.forename: Arnon
authors.initials: A
authors.lastname: Nagler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects / Q000401:mortality; D005260:Female; D006085:Graft Survival / Q000276:immunology; D006086:Graft vs Host Disease; D019337:Hematologic Neoplasms / Q000628:therapy*; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D009894:Opportunistic Infections / Q000209:etiology; D012008:Recurrence; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult