title: Double C-H activation: the palladium-catalyzed direct C-arylation of xanthines with arenes.
abstract: The novel Pd-catalyzed C(sp(2))-H/C(sp(2))-H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O(2) as oxidants exclusively yields C-8 arylated xanthines in a single synthetic operation.
authors.affiliation: Institut für Chemie, Universität Hohenheim, Garbenstrasse 30, D-70599 Stuttgart, Germany.
authors.forename: Chandi C
authors.initials: CC
authors.lastname: Malakar
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schmidt
authors.forename: Jürgen
authors.initials: J
authors.lastname: Conrad
authors.forename: Uwe
authors.initials: U
authors.lastname: Beifuss
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D014970:Xanthines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D014970:Xanthines; D010165:Palladium; D010100:Oxygen