title: A major gene effect controls resistance to caries.
abstract: Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, major gene effect controlling resistance to phenotype was detected. The frequency of the resistance allele "A" was 0.63; mean numbers of decayed teeth were 1.53 and 9.53 for genotypes AA/AB and BB, respectively. These results represent a step toward a description of the exact nature of the genetic risk factors controlling human susceptibility to caries.
authors.affiliation: Core for Advanced Molecular Investigation, Graduate Program in Health Sciences, Center for Biological and Health Sciences, Pontifical Catholic University of Paraná, Imaculada Conceição St 1155 - CCBS/PPGCS, Prado Velho, CEP 80215-901 Curitiba, Paraná, Brazil.
authors.forename: R I
authors.initials: RI
authors.lastname: Werneck
authors.forename: F P
authors.initials: FP
authors.lastname: Lázaro
authors.forename: A
authors.initials: A
authors.lastname: Cobat
authors.forename: A V
authors.initials: AV
authors.lastname: Grant
authors.forename: M B
authors.initials: MB
authors.lastname: Xavier
authors.forename: L
authors.initials: L
authors.lastname: Abel
authors.forename: A
authors.initials: A
authors.lastname: Alcaïs
authors.forename: P C
authors.initials: PC
authors.lastname: Trevilatto
authors.forename: M T
authors.initials: MT
authors.lastname: Mira
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D004245:DMF Index; D003731:Dental Caries / Q000235:genetics*; D003733:Dental Caries Susceptibility / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D015588:Observer Variation; D010375:Pedigree; D055815:Young Adult