title: Brief report: symptom onset patterns and functional outcomes in young children with autism spectrum disorders.
abstract: This study examined the relationship between onset status and current functioning using a recently proposed onset classification system in 272 young children with autism spectrum disorder (ASD). Participants were classified into one of the following groups, based on parent report using the Autism Diagnostic Interview--Revised: Early Onset (symptoms by 12 months, no loss), Delay + Regression (symptoms by 12 months plus loss), Plateau (no early symptoms or loss), and Regression (no early symptoms, followed by loss). Findings indicate that current functioning does not differ according to onset pattern, calling into question the use of onset categorizations for prognostic purposes in children with ASD.
authors.affiliation: Pediatrics and Developmental Neuroscience Branch, National Institute of Mental Health, Bethesda, MD 20892-1255, USA. shumways@mail.nih.gov
authors.forename: Stacy
authors.initials: S
authors.lastname: Shumway
authors.forename: Audrey
authors.initials: A
authors.lastname: Thurm
authors.forename: Susan E
authors.initials: SE
authors.lastname: Swedo
authors.forename: Lesley
authors.initials: L
authors.lastname: Deprey
authors.forename: Lou Ann
authors.initials: LA
authors.lastname: Barnett
authors.forename: David G
authors.initials: DG
authors.lastname: Amaral
authors.forename: Sally J
authors.initials: SJ
authors.lastname: Rogers
authors.forename: Sally
authors.initials: S
authors.lastname: Ozonoff
mesh_terms: D017668:Age of Onset; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011569:Psychiatric Status Rating Scales; D012043:Regression, Psychology