title: How to become a top model: impact of animal experimentation on human Salmonella disease research.
abstract: Salmonella serotypes are a major cause of human morbidity and mortality worldwide. Over the past decades, a series of animal models have been developed to advance vaccine development, provide insights into immunity to infection, and study the pathogenesis of human Salmonella disease. The successive introduction of new animal models, each suited to interrogate previously neglected aspects of Salmonella disease, has ushered in important conceptual advances that continue to have a strong and sustained influence on the ideas driving research on Salmonella serotypes. This article reviews important milestones in the use of animal models to study human Salmonella disease and identify research needs to guide future work.
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave., Davis, CA 95661-8645, USA.
authors.forename: Renée M
authors.initials: RM
authors.lastname: Tsolis
authors.forename: Mariana N
authors.initials: MN
authors.lastname: Xavier
authors.forename: Renato L
authors.initials: RL
authors.lastname: Santos
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Bäumler
mesh_terms: D032761:Animal Experimentation; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D012480:Salmonella Infections; D012481:Salmonella Infections, Animal