title: Myeloid differentiation factor 88 gene is involved in antiviral immunity in grass carp Ctenopharyngodon idella.
abstract: A full-length MyD88 cDNA (CiMyD88) was cloned and characterized from grass carp Ctenopharyngodon idella. CiMyD88 was found to be broadly expressed and was up-regulated by grass carp reovirus (GCRV) and CiMyD88 transcripts in vitro were rapidly elevated in C. idella kidney (CIK) cells after challenge with poly(I:C). These results suggest that CiMyD88 may be involved in the antiviral immune defence in C. idella.
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, China. su.jianguo@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Su
authors.forename: J
authors.initials: J
authors.lastname: Dong
authors.forename: T
authors.initials: T
authors.lastname: Huang
authors.forename: R
authors.initials: R
authors.lastname: Zhang
authors.forename: C
authors.initials: C
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Heng
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D002347:Carps / Q000235:genetics* / Q000276:immunology*; D005393:Fish Diseases / Q000276:immunology*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000276:immunology; D008969:Molecular Sequence Data; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics* / Q000276:immunology*; D011070:Poly I-C / Q000494:pharmacology; D012087:Reoviridae / Q000276:immunology; D012088:Reoviridae Infections / Q000276:immunology / Q000662:veterinary*; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D053594:Myeloid Differentiation Factor 88; D011070:Poly I-C