title: [Differential gene expressions in kidney Yang deficiency in individuals with sub-health status].
abstract: OBJECTIVE
  To study the gene expression profiles in kidney Yang deficiency in individuals with sub-health status.
  
  
  METHODS
  The subjects identified to have Kidney-yang deficiency and sub-health status were enrolled in this study with healthy subjects as the normal control. Using gene chip technique and MAS software, the gene expression profiles in kidney Yang deficiency in the subjects with sub-health status were analyzed.
  
  
  RESULTS
  Characteristic profiles of the differentially expressed genes were found between the kidney Yang deficiency group and normal control group. Among the total of 75 differentially expressed genes, 22 were up-regulated (with a ratio greater than 2) and 53 were down-regulated (with a ratio less than 0.5) in kidney Yang deficiency group.
  
  
  CONCLUSIONS
  Gene chip technique allows rapid and high-throughput screening for gene expression in kidney Yang deficiency and sub-health status, and a initial evidence of kidney Yang deficiency-related genes has been obtained.
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China. weimin99@yahoo.com.cn
authors.forename: Min
authors.initials: M
authors.lastname: Wei
authors.forename: Xiao-shan
authors.initials: XS
authors.lastname: Zhao
authors.forename: Xiao-min
authors.initials: XM
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Ren
authors.initials: R
authors.lastname: Luo
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006304:Health Status; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis; D059467:Transcriptome; D016711:Yang Deficiency / Q000175:diagnosis / Q000235:genetics*