title: Density of metabotropic glutamate receptors 2 and 3 (mGluR2/3) in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age.
abstract: Metabotropic glutamate receptors 2 and 3 (mGluR2/3) have been shown as efficient targets for antipsychotic intervention. We therefore investigated the receptor density of mGluR2/3 in the dorsolateral prefrontal cortex (dlPFC; Brodman area 46) of schizophrenia/schizoaffective patients (n=37) and matched controls (n=37) using receptor autoradiography. No difference in mGluR2/3 density was identified in relation to schizophrenia diagnosis. Overall and in individual groups, a negative correlation of mGluR2/3 density and age at death has been found. These and previous results suggest that density of mGluR2/3 in the dlPFC is less likely to impact on the efficiency of the mGluR2/3 agonist in treating schizophrenia symptoms.
authors.affiliation: Schizophrenia Research Institute, 405 Liverpool St, Sydney 2010, NSW, Australia. efrank@uow.edu.au
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Frank
authors.forename: Kelly Anne
authors.initials: KA
authors.lastname: Newell
authors.forename: Xu-Feng
authors.initials: XF
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D001643:Bridged Bicyclo Compounds / Q000493:pharmacokinetics; D018690:Excitatory Amino Acid Agonists / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011180:Postmortem Changes; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging* / Q000187:drug effects; D011485:Protein Binding / Q000187:drug effects; D011859:Radiography; D011869:Radioligand Assay; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D012559:Schizophrenia / Q000473:pathology*; D013223:Statistics as Topic; D014316:Tritium; D055815:Young Adult
chemical_list: D001643:Bridged Bicyclo Compounds; D018690:Excitatory Amino Acid Agonists; D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; C102718:metabotropic glutamate receptor 3; D014316:Tritium; C104753:eglumetad