title: [Outcomes of HIFU for localised prostate cancer using the Ablatherm Integrate Imaging® device].
abstract: OBJECTIVE
  To report the functional and oncological outcomes of HIFU for prostate cancer using the Ablatherm Integrate Imaging(®) device.
  
  
  METHODS
  Between January 2005 and June 2009, all patients treated with HIFU as a primary care option for localized prostate cancer and fulfilling the French Urological Association (AFU) guideline were included in this study. Validated questionnaires were used to assess continence, potencies and quality of life.
  
  
  RESULTS
  A total of 297 patients met the inclusion criteria: 149 were low risk and 148 were intermediate risk according to d'Amico's risk group. The median prostate specific antigen (PSA) nadir was 0.12ng/ml with 65% of patients reaching a nadir less than 0.3 ng/ml. Systematic control biopsies were performed on 175 patients with 89% of negative biopsies. The disease free survival rate at 40 months was 79% for low risk group and 62% for intermediate risk group. The pre and post-HIFU treatment International Prostate Symptoms Score (IPSS) score and quality of life questionnaire were not statistically different. In the opposite, the pre and post-HIFU erection function and continence status were significantly different.
  
  
  CONCLUSIONS
  Local control and Biochemical Free Survival Rate achieved with HIFU were similar to those expected with conformal external radiation beam therapy. Among the functional outcomes, potency was the most impacted by the treatment.
authors.affiliation: Service d'urologie et chirurgie de la transplantation, hôpital Edouard-Herriot, 5, place d'Arsonval, 69437 Lyon cedex 03, France. sebastien.crouzet@chu-lyon.fr
authors.forename: S
authors.initials: S
authors.lastname: Crouzet
authors.forename: L
authors.initials: L
authors.lastname: Poissonnier
authors.forename: F-J
authors.initials: FJ
authors.lastname: Murat
authors.forename: G
authors.initials: G
authors.lastname: Pasticier
authors.forename: O
authors.initials: O
authors.lastname: Rouvière
authors.forename: F
authors.initials: F
authors.lastname: Mège-Lechevallier
authors.forename: J-Y
authors.initials: JY
authors.lastname: Chapelon
authors.forename: X
authors.initials: X
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Gelet
mesh_terms: D000368:Aged; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000601:surgery*; D016896:Treatment Outcome