title: Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia.
abstract: METHODS
  We report a case of simultaneous methemoglobinemia and hemolytic anemia, probably related to the use of rasburicase, in a child starting treatment for acute lymphoblastic leukemia (ALL). In addition, the patient developed symptoms of pancreatitis. All complications resolved after 3 days of supportive therapy.
  
  
  CONCLUSIONS
  Although usually well tolerated in pediatrics, physicians prescribing rasburicase should be aware of these possible life-threatening adverse reactions.
authors.affiliation: Department of Pharmacy, Ghent University Hospital, -1 K12, De Pintelaan 185, 9000 Ghent, Belgium. tiene.bauters@uzgent.be
authors.forename: T
authors.initials: T
authors.lastname: Bauters
authors.forename: V
authors.initials: V
authors.lastname: Mondelaers
authors.forename: H
authors.initials: H
authors.lastname: Robays
authors.forename: H
authors.initials: H
authors.lastname: De Wilde
authors.forename: Y
authors.initials: Y
authors.lastname: Benoit
authors.forename: B
authors.initials: B
authors.lastname: De Moerloose
mesh_terms: D000743:Anemia, Hemolytic / Q000139:chemically induced*; D002648:Child; D006801:Humans; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced*; D010195:Pancreatitis / Q000150:complications* / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D015275:Tumor Lysis Syndrome / Q000517:prevention & control*; D014503:Urate Oxidase / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: C469709:rasburicase; D014503:Urate Oxidase