title: Syk-coupled C-type lectins in immunity.
abstract: The Syk-coupled C-type lectin receptor Dectin-1 was the first non-Toll like receptor described that could mediate its own intracellular signalling. It was initially identified as important for the innate recognition of and response to fungal pathogens but later studies revealed that it is also involved in triggering adaptive immune responses. It subsequently emerged that Dectin-1 is one of a number of spleen tyrosine kinase-coupled C-type lectin receptors that have been implicated not just in fungal immunity, but also in viral, mycobacterial and helminth infections. Here, we consider the ability of these receptors to trigger different aspects of immunity and highlight their emerging roles in a number of infection scenarios.
authors.affiliation: Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Kerrigan
authors.forename: Gordon D
authors.initials: GD
authors.lastname: Brown
mesh_terms: D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D037181:Lectins, C-Type / Q000276:immunology* / Q000378:metabolism; D008024:Ligands; D008565:Membrane Proteins / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000276:immunology; D011485:Protein Binding; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D018003:Receptors, Calcitonin / Q000276:immunology; D000072377:Syk Kinase; D000099181:Dectin-1
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D037181:Lectins, C-Type; D008024:Ligands; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011505:Protein-Tyrosine Kinases; D018003:Receptors, Calcitonin; D000072377:Syk Kinase; D000099181:Dectin-1; C000606896:SYK protein, human