title: Locking the genome: nuclear organization and cell fate.
abstract: The differentiation of pluripotent or totipotent cells into various differentiated cell types is accompanied by a restriction of gene expression patterns, alteration in histone and DNA methylation, and changes in the gross nuclear organization of eu- and heterochromatic domains. Several recent studies have coupled genome-wide mapping of histone modifications with changes in gene expression. Other studies have examined changes in the subnuclear positioning of tissue-specific genes upon transcriptional induction or repression. Here we summarize intriguing correlations of the three phenomena, which suggest that in some cases causal relationships may exist.
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Meister
authors.forename: Susan E
authors.initials: SE
authors.lastname: Mango
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gasser
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D002467:Cell Nucleus / Q000235:genetics*; D044127:Epigenesis, Genetic; D005819:Genetic Markers; D016678:Genome; D006801:Humans
chemical_list: D005819:Genetic Markers