title: Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes.
abstract: BACKGROUND
  Some persistent environmental chemicals are suspected of causing an increased risk of type 2 diabetes mellitus, a disease particularly common after the age of 70. This concern was examined in a cross-sectional study of elderly subjects from a fishing population with elevated contaminant exposures from seafood species high in the food chain.
  
  
  METHODS
  Clinical examinations of 713 Faroese residents aged 70-74 years (64% of eligible population) included fasting plasma concentrations of glucose and insulin, and glycosylated hemoglobin. Lifetime exposure to persistent environmental chemicals from pilot whale and other traditional food was estimated from a dietary questionnaire and by analysis of blood samples for polychlorinated biphenyls (PCBs) and related food contaminants.
  
  
  RESULTS
  Septuagenarians with type 2 diabetes or impaired fasting glycemia tended to have higher PCB concentrations and higher past intake of traditional foods, especially during childhood and adolescence. In nondiabetic subjects, the fasting insulin concentration decreased by 7% (95% CI = -12% to -2%) for each doubling of the PCB concentration after adjustment for sex and body mass index at age 20. Conversely, the fasting glucose concentration increased by 6% (-1% to 13%) for each doubling in PCB. Similar associations were seen in subjects without impaired fasting glycemia, while further adjustment for current body mass index and lipid metabolism parameters attenuated some of the associations.
  
  
  CONCLUSIONS
  Impaired insulin secretion appears to constitute an important part of the type 2 diabetes pathogenesis associated with exposure to persistent lipophilic food contaminants.
authors.affiliation: Institute of Public Health, University of Southern Denmark, Odense, Denmark. pgrand@hsph.harvard.edu
authors.forename: Philippe
authors.initials: P
authors.lastname: Grandjean
authors.forename: Jan Erik
authors.initials: JE
authors.lastname: Henriksen
authors.forename: Anna L
authors.initials: AL
authors.lastname: Choi
authors.forename: Maria Skaalum
authors.initials: MS
authors.lastname: Petersen
authors.forename: Christine
authors.initials: C
authors.lastname: Dalgård
authors.forename: Flemming
authors.initials: F
authors.lastname: Nielsen
authors.forename: Pal
authors.initials: P
authors.lastname: Weihe
mesh_terms: D017677:Age Distribution; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D020387:Food Chain; D005506:Food Contamination; D006801:Humans; D015994:Incidence; D007328:Insulin / Q000097:blood*; D008297:Male; D009664:Norway; D016017:Odds Ratio; D011078:Polychlorinated Biphenyls / Q000009:adverse effects / Q000097:blood*; D018570:Risk Assessment; D017747:Seafood / Q000009:adverse effects*; D017678:Sex Distribution
chemical_list: D001786:Blood Glucose; D007328:Insulin; D011078:Polychlorinated Biphenyls