title: Handling and reporting of transurethral resection specimens of the bladder in Europe: a web-based survey by the European Network of Uropathology (ENUP).
abstract: OBJECTIVE
  To collect of information about European practices on handling and reporting of transurethral resection specimens of the bladder.
  
  
  RESULTS
  The European Network of Uropathology is a communication network that includes 335 pathology laboratories in 15 western European countries. A web-based questionnaire was answered by 52.2% of members. Some routines were adopted by a majority: formalin fixation (92.5%), separate containers for tumour and resection base (72%) and embedding of the entire specimen (60%). Cancer along/in adipose tissue would be reported as pT3a by 19.5% and non-invasive urothelial carcinoma in prostatic ducts/glands as pT4a by 16.1%. Papillary urothelial neoplasia of low malignant potential is recognized by 72.6% but rarely reported. Immunohistochemistry is rarely or sometimes used for diagnosing bladder cancer by 91.7%, and the most frequently used markers are CK20 (76.9%), CK7 (66.7%) and Ki67 (38.8%). Only 24.8% report prognostic markers, with Ki67 (84.4%) and p53 (64.4%) being most common. Only 50.9% use the International Society of Urological Pathology 1998/World Health Organization (WHO) 2004 grading system, followed by WHO 1973 (43.4%) and WHO 1999 (31.4%).
  
  
  CONCLUSIONS
  There is still variability in routine practice and a need for standardization of methodologies. These results may be helpful when judging what recommendations are reasonable to issue.
authors.affiliation: Unit of Anatomic Pathology, Cordoba University Medical School, Cordoba, Spain. em1lobea@uco.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Beltran
authors.forename: Ferran
authors.initials: F
authors.lastname: Algaba
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Berney
authors.forename: Liliane
authors.initials: L
authors.lastname: Boccon-Gibod
authors.forename: Philippe
authors.initials: P
authors.lastname: Camparo
authors.forename: David
authors.initials: D
authors.lastname: Griffiths
authors.forename: Gregor
authors.initials: G
authors.lastname: Mikuz
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
authors.forename: Murali
authors.initials: M
authors.lastname: Varma
authors.forename: Lars
authors.initials: L
authors.lastname: Egevad
mesh_terms: D015653:Cystectomy / Q000379:methods*; D005060:Europe; D006801:Humans; D020407:Internet; D008297:Male; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010336:Pathology; D044382:Population Groups; D013048:Specimen Handling / Q000592:standards*; D011795:Surveys and Questionnaires; D001743:Urinary Bladder / Q000473:pathology / Q000601:surgery*; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*; D014572:Urology