title: Cross-sectional analysis of cardiovascular risk factors in children with parental history of premature ischemic heart disease.
abstract: This study aimed to evaluate the presence of cardiovascular risk factors in children with a parental history of premature ischemic heart disease (two- or three-vessel disease diagnosed before the age of 55 in men and 65 in women). A prospective cross-sectional study was performed on 55 children. The following parameters were assessed: body mass index (BMI), waist and hip circumference, blood pressure, lipids profile, fasting glucose (FG), C-reactive protein (CRP), and carotid intimal-medial thickness (CIMT). Twenty-eight children had hypercholesterolemia, and 11 had other forms of dyslipidemia. Sixteen children had a high BMI; 17 had increased CRP levels; 2 were hypertensive; and 2 had impaired FG. CIMT levels were not correlated with age (Pearson r = -0.486; p = 0.78) and height (Pearson r = -6.31; p = 0.84), but they were correlated with cholesterol levels (Spearman r = 0.375; p < 0.005). Most patients (83%) had ≥ 2 risk factors; half of them had ≥ 3 risk factors. We concluded that these at-risk children should be carefully screened for all known risk factors.
authors.affiliation: Department of Pediatrics, Meyer Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
authors.forename: Gal
authors.initials: G
authors.lastname: Neuman
authors.forename: Itai
authors.initials: I
authors.lastname: Shavit
authors.forename: Doron
authors.initials: D
authors.lastname: Aronson
authors.forename: Avraham
authors.initials: A
authors.lastname: Lorber
authors.forename: Diana
authors.initials: D
authors.lastname: Gaitini
authors.forename: Roy
authors.initials: R
authors.lastname: Onn
authors.forename: Naim
authors.initials: N
authors.lastname: Shehadeh
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002339:Carotid Arteries / Q000473:pathology; D002648:Child; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000235:genetics; D007557:Israel; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000235:genetics*; D011446:Prospective Studies; D012016:Reference Values; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014463:Ultrasonography; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D008055:Lipids; D002784:Cholesterol