title: Successful treatment of a patient with IgG4-related disease with a paravertebral mass lesion.
abstract: A 68-year-old woman was admitted with bleary eyes and lacrimal gland swelling. A biopsy specimen from a right paravertebral mass lesion detected by computed tomography showed remarkable IgG4-positive plasma cells. Because serum IgG4 was elevated to 3300 mg/dl, IgG4-related disease was diagnosed, with the assistance of fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT). Administration of 30 mg of oral prednisolone effectively reduced the lacrimal gland swelling and paravertebral mass volume. Nine months after the initiation of prednisolone, serum IgG4 was reduced to 31.4 mg/dl, and there was norecurrence.
authors.affiliation: Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki, 852-8501, Japan. nhideki@nagasaki-u.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Keiko
authors.initials: K
authors.lastname: Hisatomi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Koga
authors.forename: Akinari
authors.initials: A
authors.lastname: Mizokami
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamasaki
authors.forename: Mami
authors.initials: M
authors.lastname: Tamai
authors.forename: Tomoki
authors.initials: T
authors.lastname: Origuchi
authors.forename: Junji
authors.initials: J
authors.lastname: Irie
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D010950:Plasma Cells / Q000276:immunology; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000627:therapeutic use*; D012185:Retroperitoneal Fibrosis / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G; D011239:Prednisolone