title: [Radiation-induced DNA double-stranded breaks and the dynamics of apoptotic death of human peripheral lymphocytes].
abstract: DNA double-stranded breaks and their association with the development of radiation-induced peripheral lymphocyte apoptosis were studied in healthy donors exposed to in vitro gamma-irradiation in a dose of 1 Gy. It was shown that irradiation in 1-Gy dose caused a significant (p < 0.05) increase in the frequency of cells in late apoptosis 4 hours after irradiation and a rise in their frequency in early apoptosis 24 hours following this procedure. A significant correlation (r = 0.52, p < 0.05) was recorded between the primary level of radiation-induced DNA double-stranded breaks and the frequency of cells in late apoptosis following 4 hours, which suggests that DNA double-stranded breaks as a signal to trigger cell apoptotic death are of great importance.
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Vorob'eva
authors.forename: O V
authors.initials: OV
authors.lastname: Boeva
authors.forename: A N
authors.initials: AN
authors.lastname: Osipov
authors.forename: V K
authors.initials: VK
authors.lastname: Bozhenko
mesh_terms: D017304:Annexin A5; D017209:Apoptosis / Q000528:radiation effects*; D016923:Cell Death; D020552:Comet Assay; D053903:DNA Breaks, Double-Stranded / Q000528:radiation effects*; D004249:DNA Damage; D003627:Data Interpretation, Statistical; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000528:radiation effects*; D011829:Radiation Dosage; D011836:Radiation Tolerance; D013997:Time Factors
chemical_list: D017304:Annexin A5