title: Schizophrenia: a systematic review of the disease state, current therapeutics and their molecular mechanisms of action.
abstract: The treatment of schizophrenia, one of the most debilitating mental illnesses, began by the serendipitous discovery of chlorpromazine. Since then, researchers have endeavored to find the cause of the illness but it remains unresolved. As a result, literature on the etiology of schizophrenia is littered with hypotheses and theories that are constantly reviewed, modified and rejected. Two hypotheses, however, have withstood the test of time and serve as the basis for the drug treatment, namely the dopamine and serotonin hypotheses. This review introduces the disease state, summarizes in detail the two leading hypotheses on schizophrenia, presents drugs that are currently available for treatment, and discusses some of the promising drug candidates based on their pre and early clinical trial results.
authors.affiliation: Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
authors.forename: J K
authors.initials: JK
authors.lastname: Shin
authors.forename: D T
authors.initials: DT
authors.lastname: Malone
authors.forename: I T
authors.initials: IT
authors.lastname: Crosby
authors.forename: B
authors.initials: B
authors.lastname: Capuano
mesh_terms: D014150:Antipsychotic Agents / Q000737:chemistry* / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D018492:Dopamine Antagonists / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D011954:Receptors, Dopamine / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D011985:Receptors, Serotonin / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D012702:Serotonin Antagonists / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists