title: Mulberry water extracts possess an anti-obesity effect and ability to inhibit hepatic lipogenesis and promote lipolysis.
abstract: Obesity plays a critical role in dyslipidemia and related disorders. Mulberry water extracts (MWEs) contain polyphenols, including gallic acid, chlorogenic acid, rutin, and anthocyanins. In this study, using 6-week-old male hamsters, we investigated the anti-obese effect of MWEs. After 12 weeks of treatment, MWEs lowered high-fat diet (HFD)-induced body weight and visceral fat, accompanied with hypolipidemic effects by reducing serum triacylglycerol, cholesterol, free fatty acid, and the low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio (n=8 for each group). MWEs decreased hepatic lipids, thus protected livers from impairment. The hepatic peroxisome proliferator-activated receptor α and carnitine palmitoyltransferase-1 were elevated, while fatty acid synthase and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase were reduced by MWEs, indicating that MWEs regulated lipogenesis and lipolysis, which exerted the anti-obese and hypolipidemic effects. Noticeably, MWEs showed both efficacy and safety in vivo. In concluson, MWEs can be used to reduce body weight, serum, and liver lipids.
authors.affiliation: Division of Basic Medical Science, Hungkuang University, and Department of Internal Medicine, Chung-Shan Medical University Hospital, Number 34, Chung Chie Road, Shalu County, Taichung 433, Taiwan.
authors.forename: Chiung-Huei
authors.initials: CH
authors.lastname: Peng
authors.forename: Li-Kaung
authors.initials: LK
authors.lastname: Liu
authors.forename: Chao-Ming
authors.initials: CM
authors.lastname: Chuang
authors.forename: Charng-Cherng
authors.initials: CC
authors.lastname: Chyau
authors.forename: Chieng-Ning
authors.initials: CN
authors.lastname: Huang
authors.forename: Chau-Jong
authors.initials: CJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage*; D006224:Cricetinae; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects*; D006801:Humans; D050155:Lipogenesis / Q000187:drug effects*; D008066:Lipolysis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D031625:Morus / Q000737:chemistry*; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage*
chemical_list: D019440:Anti-Obesity Agents; D010936:Plant Extracts