title: Myeloid antigen positivity in Turkish children with acute lymphoblastic leukemia lacks influence on prognosis.
abstract: BACKGROUND
  Several studies have suggested that the presence of myeloid antigens is a poor prognostic factor in patients with acute lymphoid leukemia (ALL).
  
  
  OBJECTIVE
  We aimed to assess this possibility in Turkish patients.
  
  
  METHODS
  Seventy-three children with a diagnosis of ALL-L1 and 38 with ALL-L2 were included. Flow cytometry and fluorescein-isothiocynate conjugated antibodies were used to determined surface antigens on blasts.
  
  
  RESULTS
  Myeloid antigens were positive in 48.4% with ALL-L1 and 60.5% with ALL-L2, the difference not being significant. Overall survival rates of myeloid antigen positive patients at 36, 60, and 72 months were 76%, 58%, and 48%, respectively, comparable to the corresponding 70%, 56%, and 46% in myeloid antigen negative patients (p >0.05).
  
  
  CONCLUSIONS
  We did not find any association between myeloid antigen positivity and clinical and laboratory features of ALL.
authors.affiliation: Department of Pediatric Oncology, Cukurova University Faculty of Medicine, Adana, Turkey.
authors.forename: Atila
authors.initials: A
authors.lastname: Tanyeli
authors.forename: Fatih
authors.initials: F
authors.lastname: Erbey
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Bayram
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kömür
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology / Q000378:metabolism*; D000954:Antigens, Surface / Q000276:immunology / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000628:therapy; D011379:Prognosis; D015996:Survival Rate
chemical_list: D000911:Antibodies, Monoclonal; D015214:Antigens, Differentiation, Myelomonocytic; D000954:Antigens, Surface; D014408:Biomarkers, Tumor