title: Helicobacter pylori therapy in children: a focus on proton pump inhibitors.
abstract: Over the last two decades, there have been many studies on children who have sought an effective and safe treatment to eradicate Helicobacter pylori infection, but as yet, no therapy regimen has been found which is always effective and safe. Differences in drug response among pediatric patients are common. Such individual variability in drug response is multifactorial, including environmental, genetic, development and disease determinants that affect the disposition of a given drug. In pediatric efficacy studies for the management of H. pylori eradication in children, the most commonly tested regimen has contained a combination of proton pump inhibitor (PPI), clarithromycin and amoxicillin, followed by triple therapies containing PPI, clarithromycin and nitroimidazoles. Thus, PPIs are an integral part of triple therapy for H. pylori eradication in children with gastroduodenal disease. In this article, we comprehensively review, from a pediatric point of view, the literature on the clinical, pharmacologic and microbiologic properties of PPIs. We also discuss genetic, developmental and other host-related factors that may affect the efficacy of these drugs. Finally, we provide some guidance regarding their potential role and limitations for H. pylori eradication in children.
authors.affiliation: Institute of Molecular Medicine, National Research Council, Rome, Italy. claudio.chiesa@artov.inmm.cnr.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Chiesa
authors.forename: Caterina
authors.initials: C
authors.lastname: Anania
authors.forename: Lucia
authors.initials: L
authors.lastname: Pacifico
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Olivero
authors.forename: John F
authors.initials: JF
authors.lastname: Osborn
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D002648:Child; D065731:Cytochrome P-450 CYP2C19; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D011110:Polymorphism, Genetic; D054328:Proton Pump Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19