title: Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists.
abstract: 2,4-Diaminopyrimidines derivatives were developed as a novel class of SNSR4 antagonists. Structure activity relationship of the diamino pyrimidine core was explored and a tool compound suitable for target validation was identified.
authors.affiliation: Department of Medicinal Chemistry, AstraZeneca R&D Montreal, 7171 Frederick-Banting, Montréal, Québec, Canada H4S 1Z9.
authors.forename: Malken
authors.initials: M
authors.lastname: Bayrakdarian
authors.forename: Joanne
authors.initials: J
authors.lastname: Butterworth
authors.forename: Yun-Jin
authors.initials: YJ
authors.lastname: Hu
authors.forename: Vijayaratnam
authors.initials: V
authors.lastname: Santhakumar
authors.forename: Mirosław J
authors.initials: MJ
authors.lastname: Tomaszewski
mesh_terms: D020128:Inhibitory Concentration 50; D011743:Pyrimidines / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D011984:Sensory Receptor Cells / Q000187:drug effects* / Q000378:metabolism
chemical_list: D011743:Pyrimidines; D011956:Receptors, Cell Surface; C017205:2,4-diaminopyrimidine