title: [Review and update of the prognostic factors in lung metastasis surgery].
abstract: BACKGROUND
  Since the International Registry of Lung Metastases established the factors that determine survival after performing lung metastasectomy in 1997, numerous studies have attempted to determine these prognostic factors of survival. Our objective has been to analyse the mortality, survival and disease-free survival lung metastasis surgery by studying the different variables that determine them.
  
  
  METHODS
  All patients subjected to surgery for lung metastasectomy between 1998 and 2008 were included in this study. The Kaplan-Meier and log-rank tests were performed, as well as a Cox regression using multivariate analysis.
  
  
  RESULTS
  A total of 178 lung metastases were removed in 146 patients during this period. The mean age was 62.22 years (median 63 years) and 64.6% were males. There were 2 cases (1.1%) of mortality and the incidence of complications was 5.02% (9 cases). The overall survival was 67.75 months with a 3 and 5 year survival of 67.4% and 52.4%, respectively. The variables that showed statistical significance in the multivariate analysis were: age disease free interval, number of nodules and size of nodules. The "state of the margins" variable was almost significant (P=.054).
  
  
  CONCLUSIONS
  To have only one metastasis and it is less than 1cm, a long disease free interval, and a resection with free margins, are the most favourable prognostic factors after resection of lung metastasis.
authors.affiliation: Servicio de Cirugía Torácica, Hospital Donostia, San Sebastián, Guipúzcoa, España. Jon.zabaletajimenez@osakidetza.net
authors.forename: Jon
authors.initials: J
authors.lastname: Zabaleta
authors.forename: Borja
authors.initials: B
authors.lastname: Aguinagalde
authors.forename: Marta G
authors.initials: MG
authors.lastname: Fuentes
authors.forename: José M
authors.initials: JM
authors.lastname: Izquierdo
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Hernández
authors.forename: Jose I
authors.initials: JI
authors.lastname: Emparanza
mesh_terms: D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011379:Prognosis; D015996:Survival Rate