title: [Recent advances in the study of new antifungal lead compounds].
abstract: In recent years, the incidence and mortality rate of invasive fungal infection have increased dramatically, and it is of great significance to develop novel antifungal agents with new chemical structure and new mode of action. In this review, novel antifungal lead compounds reported from 2007 to 2009 are reviewed. Moreover, their chemical structures, antifungal activities and structure-activity relationships have been summarized, which can provide useful information for future study of antifungal agents.
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Sheng-zheng
authors.initials: SZ
authors.lastname: Wang
authors.forename: Chun-quan
authors.initials: CQ
authors.lastname: Sheng
authors.forename: Wan-nian
authors.initials: WN
authors.lastname: Zhang
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005658:Fungi / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D055666:Lipopeptides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015394:Molecular Structure; D009181:Mycoses / Q000188:drug therapy; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D006571:Heterocyclic Compounds; D055666:Lipopeptides; D009570:Nitriles; D010936:Plant Extracts; D011725:Pyridines; D011799:Quinazolines; D011809:Quinones; D013844:Thiazoles; D014230:Triazoles; C476911:aminocandin; C508735:isavuconazole; C104066:ER 30346; C112424:albaconazole