title: Microwave tomography of extremities: 2. Functional fused imaging of flow reduction and simulated compartment syndrome.
abstract: Medical imaging has recently expanded into the dual- or multi-modality fusion of anatomical and functional imaging modalities. This significantly improves the diagnostic power while simultaneously increasing the cost of already expensive medical devices or investigations and decreasing their mobility. We are introducing a novel imaging concept of four-dimensional (4D) microwave tomographic (MWT) functional imaging: three dimensional (3D) in the spatial domain plus one dimensional (1D) in the time, functional dynamic domain. Instead of a fusion of images obtained by different imaging modalities, 4D MWT fuses absolute anatomical images with dynamic, differential images of the same imaging technology. The approach was successively validated in animal experiments with short-term arterial flow reduction and a simulated compartment syndrome in an initial simplified experimental setting using a dedicated MWT system. The presented fused images are not perfect as MWT is a novel imaging modality at its early stage of the development and ways of reading reconstructed MWT images need to be further studied and understood. However, the reconstructed fused images present clear evidence that microwave tomography is an emerging imaging modality with great potentials for functional imaging.
authors.affiliation: School of Medicine, ISTM, Keele University, Stoke-on-Trent, ST4 7QB, UK. s.semenov@pmed.keele.ac.uk
authors.forename: Serguei
authors.initials: S
authors.lastname: Semenov
authors.forename: James
authors.initials: J
authors.lastname: Kellam
authors.forename: Bindu
authors.initials: B
authors.lastname: Nair
authors.forename: Thomas
authors.initials: T
authors.lastname: Williams
authors.forename: Michael
authors.initials: M
authors.lastname: Quinn
authors.forename: Yuri
authors.initials: Y
authors.lastname: Sizov
authors.forename: Alexei
authors.initials: A
authors.lastname: Nazarov
authors.forename: Andrey
authors.initials: A
authors.lastname: Pavlovsky
mesh_terms: D000818:Animals; D001775:Blood Circulation; D003161:Compartment Syndromes / Q000503:physiopathology*; D005121:Extremities / Q000098:blood supply* / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008872:Microwaves; D008954:Models, Biological; D015424:Reperfusion; D013552:Swine; D014054:Tomography / Q000379:methods*