title: Dosimetric validation of the Acuros XB Advanced Dose Calculation algorithm: fundamental characterization in water.
abstract: A new algorithm, Acuros® XB Advanced Dose Calculation, has been introduced by Varian Medical Systems in the Eclipse planning system for photon dose calculation in external radiotherapy. Acuros XB is based on the solution of the linear Boltzmann transport equation (LBTE). The LBTE describes the macroscopic behaviour of radiation particles as they travel through and interact with matter. The implementation of Acuros XB in Eclipse has not been assessed; therefore, it is necessary to perform these pre-clinical validation tests to determine its accuracy. This paper summarizes the results of comparisons of Acuros XB calculations against measurements and calculations performed with a previously validated dose calculation algorithm, the Anisotropic Analytical Algorithm (AAA). The tasks addressed in this paper are limited to the fundamental characterization of Acuros XB in water for simple geometries. Validation was carried out for four different beams: 6 and 15 MV beams from a Varian Clinac 2100 iX, and 6 and 10 MV 'flattening filter free' (FFF) beams from a TrueBeam linear accelerator. The TrueBeam FFF are new beams recently introduced in clinical practice on general purpose linear accelerators and have not been previously reported on. Results indicate that Acuros XB accurately reproduces measured and calculated (with AAA) data and only small deviations were observed for all the investigated quantities. In general, the overall degree of accuracy for Acuros XB in simple geometries can be stated to be within 1% for open beams and within 2% for mechanical wedges. The basic validation of the Acuros XB algorithm was therefore considered satisfactory for both conventional photon beams as well as for FFF beams of new generation linacs such as the Varian TrueBeam.
authors.affiliation: Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona, Switzerland. afc@iosi.ch
authors.forename: Antonella
authors.initials: A
authors.lastname: Fogliata
authors.forename: Giorgia
authors.initials: G
authors.lastname: Nicolini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Clivio
authors.forename: Eugenio
authors.initials: E
authors.lastname: Vanetti
authors.forename: Pietro
authors.initials: P
authors.lastname: Mancosu
authors.forename: Luca
authors.initials: L
authors.lastname: Cozzi
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D006801:Humans; D008954:Models, Biological; D017785:Photons / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water