title: Association of age with the level of response in the QuantiFERON-TB Gold In-Tube assay for children with active tuberculosis.
abstract: QuantiFERON-TB data from 50 children with tuberculosis were analysed to evaluate age related effects. Significantly higher IFN-? responses to TB-specific antigens were associated with younger age, but no difference was found with Mitogen responses. Extrapolating IGRA responses to a Mitogen does not reflect those induced by an antigen-specific stimulus. QFT-IT responses to TB-specific antigens are not compromised with young age.
authors.affiliation: Laboratory of Mediators of Inflammation and Immunity, Department of Immunology and Allergology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria. markova@ncipd.org
authors.forename: Roumiana
authors.initials: R
authors.lastname: Markova
authors.forename: Rumiana
authors.initials: R
authors.lastname: Drenska
authors.forename: Petko
authors.initials: P
authors.lastname: Minchev
authors.forename: Yana
authors.initials: Y
authors.lastname: Todorova
authors.forename: Massimo
authors.initials: M
authors.lastname: Ciccozzi
authors.forename: Massimo
authors.initials: M
authors.lastname: Amicosante
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000942:Antigens, Bacterial / Q000276:immunology; D001500:BCG Vaccine / Q000276:immunology; D002031:Bulgaria; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000032:analysis* / Q000096:biosynthesis; D008297:Male; D008934:Mitogens / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000502:physiology; D011933:Reagent Kits, Diagnostic / Q000592:standards*; D014376:Tuberculosis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology
chemical_list: D000942:Antigens, Bacterial; D001500:BCG Vaccine; D008934:Mitogens; D011933:Reagent Kits, Diagnostic; D007371:Interferon-gamma