title: Necrotic cell death: harnessing the Dark side of the Force in mammary gland involution.
abstract: In response to major cellular insults, a massive increase in lysosomal membrane permeability (LMP) leads to necrosis. Data now reveal that this potent lysosomal-mediated necrotic cell-death machinery can also be harnessed for complex physiological processes, such as post-lactation mammary gland involution.
authors.forename: Cliff J
authors.initials: CJ
authors.lastname: Luke
authors.forename: Gary A
authors.initials: GA
authors.lastname: Silverman
mesh_terms: D000818:Animals; D001940:Breast / Q000473:pathology*; D005260:Female; D006801:Humans; D007774:Lactation; D008247:Lysosomes / Q000201:enzymology / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000473:pathology*; D009336:Necrosis; D010539:Permeability; D015398:Signal Transduction; D014886:Weaning