title: Focal segmental glomerulosclerosis in IgA nephropathy: a result of primary podocyte injury?
abstract: Segmental sclerosis is frequently seen in IgA nephropathy and is an adverse prognostic indicator in the Oxford classification. Hill and colleagues have studied patients with IgA nephropathy and show that the segmental sclerotic lesions have features that suggest they are due to primary podocyte injury. They confirm the validity of the Oxford classification in predicting outcome and also show that categorizing the type of FSGS is of prognostic significance, with collapsing and cellular forms having the worst outcome.
authors.affiliation: Department of Medicine, Imperial College, London, UK. Electronic address: t.cook@imperial.ac.uk.
authors.forename: H Terence
authors.initials: HT
authors.lastname: Cook
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D018450:Disease Progression; D005922:Glomerulonephritis, IGA / Q000145:classification / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D005923:Glomerulosclerosis, Focal Segmental / Q000145:classification / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D050199:Podocytes / Q000737:chemistry / Q000473:pathology; D011379:Prognosis
chemical_list: D015415:Biomarkers