title: [Relationship between expression of chemokine receptor and curative effect of multiple myeloma].
abstract: This study was purposed to explore the correlation of CXCR4, CCR1, CCR2 expression with curative effect of multiple myeloma (MM). Flow cytometry was used to detect the expressions of CXCR4, CCR1, CCR2 on cell surface of bone marrow from 48 newly diagnosed MM patients. These patients were divided into two groups: one group with expression of chemokine receptor (group I) and another group without expression of chemokine receptor (group II). The group I was consisted of 34 patients, but 3 out of them could not be continuously followed up. The group II was consisted of 14 patients. The MM patients of 2 groups were treated with chemotherapeutic drugs for 3 and 6 months, the curative efficacy of 2 groups were compared. The results showed that after treating for 3 and 6 months the effective rates of group I and group II were 80.6% (25/31) vs 50% (7/14) and 83.9% (26/31) vs 50% (7/14) respectively, which suggested that curative efficacy of group I was better than that of group II (p < 0.05). It is concluded that CXCR4, CCR1, CCR2 may be used as indexes for evaluating curative effect of MM patients.
authors.affiliation: Department of Hematology, Yin Zhou People Hospital, Ningbo 315040, Zhejiang Province, China. txtx1978@sina.com
authors.forename: Ren-Zhi
authors.initials: RZ
authors.lastname: Pei
authors.forename: Shan-Hao
authors.initials: SH
authors.lastname: Tang
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Ma
authors.forename: Pi-Sheng
authors.initials: PS
authors.lastname: Zhang
authors.forename: Xu-Hui
authors.initials: XH
authors.lastname: Liu
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: DU
authors.forename: Ze
authors.initials: Z
authors.lastname: Chen
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.forename: Ke-Ya
authors.initials: KY
authors.lastname: Sha
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Cao
authors.forename: Shuang-Yue
authors.initials: SY
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000378:metabolism*; D054389:Receptors, CCR1 / Q000378:metabolism*; D054390:Receptors, CCR2 / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: C515300:CCR1 protein, human; C515334:CCR2 protein, human; C527276:CXCR4 protein, human; D054389:Receptors, CCR1; D054390:Receptors, CCR2; D019718:Receptors, CXCR4