title: [In vitro balanced sustained-release of Panax notoginseng saponins controlled with various matrix materials].
abstract: To explore the influence of matrix materials in complicate ingredients on traditional Chinese medicine and investigate the excipients selection model based on balanced release characteristics of multicomponents, the influence of HPMC (K4M, K15M, K100M) and Carbomer (934P, 971P, 974P) was illustrated by testing in vitro release of ginsenoside-Rg1, ginsenoside-Rb1 and notoginsenoside-R1 in Panax notoginseng saponins (model drug, PNS). According to in vitro release results of PNS matrix tablets in water and artificial intestinal juice, the release curves were analyzed with Peppas equation and simulating factor (f). Significant differences in k value and n value among ginsenoside-Rg1, ginsenoside-Rb1 and notoginsenoside-R1 existed in various formulations. The release behaviors from various excipients could be described with Non-Fickian transport or super Case II transport pattern. The f2 values for ginsenoside-Rg1, ginsenoside-Rb1 and notoginsenoside-R1 in 971P matrix tablet containing 30% Carbomer 971P were 74.91, 53.45, 57.89 in water and 79.35, 55.51, 51.89 in artificial intestinal juice, respectively. The release profiles fit for the regulation of FDA. The result revealed that the balanced release rates of Rg1, Rb1 and R1 in 971P matrix tablet were obtained.
authors.affiliation: Shaanxi University of Chinese Medicine, Xianyang 712046, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhou
authors.forename: Chao-Mei
authors.initials: CM
authors.lastname: Fu
authors.forename: Yao
authors.initials: Y
authors.lastname: He
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Zhang
authors.forename: Hong-Ya
authors.initials: HY
authors.lastname: Liu
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000180:Acrylic Resins / Q000737:chemistry; D003692:Delayed-Action Preparations; D005079:Excipients / Q000737:chemistry*; D036145:Ginsenosides / Q000302:isolation & purification / Q000493:pharmacokinetics; D007785:Lactose / Q000031:analogs & derivatives / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D053723:Panax notoginseng / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D013607:Tablets
chemical_list: D000179:Acrylates; D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D005079:Excipients; D036145:Ginsenosides; D012503:Saponins; D013607:Tablets; C479038:carbomer; C492577:carbopol 971P; C509290:hydroxypropylmethylcellulose-lactose matrix; C442759:ginsenoside Rb1; D008747:Methylcellulose; D007785:Lactose; C035054:ginsenoside Rg1; C072936:notoginsenoside R1