title: Levantilides A and B, 20-membered macrolides from a Micromonospora strain isolated from the Mediterranean deep sea sediment.
abstract: Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6 ‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.
authors.affiliation: Kieler Wirkstoff-Zentrum at IFM-GEOMAR (Leibniz Institute of Marine Sciences), AmKiel-Kanal 44, 24106 Kiel, Germany. agaertner@ifm-geomar.de
authors.forename: Andrea
authors.initials: A
authors.lastname: Gärtner
authors.forename: Birgit
authors.initials: B
authors.lastname: Ohlendorf
authors.forename: Dirk
authors.initials: D
authors.lastname: Schulz
authors.forename: Heidi
authors.initials: H
authors.lastname: Zinecker
authors.forename: Jutta
authors.initials: J
authors.lastname: Wiese
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D059001:Aquatic Organisms; D001419:Bacteria / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004777:Environment; D005658:Fungi / Q000187:drug effects; D019015:Geologic Sediments / Q000382:microbiology*; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D008522:Mediterranean Sea; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000737:chemistry* / Q000302:isolation & purification; D010802:Phylogeny
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D018942:Macrolides