title: [Study on the relationship between the expression of matrix metalloproteinase-9 and premature rupture of membrane as pregnant women with periodontal inflammation].
abstract: OBJECTIVE
  To analyze the relationship between periodontal condition and premature rupture of membrane (PROM) in order to provide basis to keep pregnant women from oral diseases.
  
  
  METHODS
  18 cases of preterm pregnant women with PROM (Group PPROM) and 20 cases of full-term pregnant women with PROM (Group PROM) were selected as the study group, and 28 cases of full-term normal pregnant women were selected as the control group. Everyone's plaque index (PLI), probing depth (PD) and sulcular bleeding index (SBI) were checked and recorded. Meanwhile, immunohistochemical method was used to detect the distribution and expression of matrix metalloproteinase-9 (MMP-9) in fetal membrane of cervix. The relationship between the expression of MMP-9 and PROM was analyzed.
  
  
  RESULTS
  The expression of MMP-9 in the pregnant women with PROM (Group PPROM and Group PROM) was higher than that in the control group. There was no relationship between the expression of MMP-9 in chorion and PD (r = 0.053, P = 0.075). The expression of MMP-9 in chorion had direct correlation with SBI (r = 0.433, P < 0.05) and PLI (r = 0.310, P < 0.05). The expression of MMP-9 in amniotic membrane hadn't dependence with PD (r = 0.077, P = 0.597), while had direct correlation with SBI (r = 0.430, P < 0.05) and PLI (r = 0.324, P < 0.05).
  
  
  CONCLUSIONS
  MMP-9 was involved in the pathological process of PROM and periodontal inflammation.
authors.affiliation: Dept. of Gynaecology and Obstetrics, The First Hospital of Jilin University, Changchun 130041, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Cheng
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
mesh_terms: D005260:Female; D005322:Premature Rupture of Fetal Membranes; D006801:Humans; D007249:Inflammation; D020780:Matrix Metalloproteinase 9; D011247:Pregnancy
chemical_list: D020780:Matrix Metalloproteinase 9