title: Virus driven evolution: a probable explanation for "Similia Similibus Curantur" philosophy.
abstract: Despite the advances in biomedical knowledge, there remain many challenging and significant unsolved problems among which are included viral pathogenesis and antiviral therapy, as main topics in human health. On this respect, for instance, our knowledge about human immunodeficiency virus and AIDS is still insufficient to deal with problems of immense significance, such as the possible "natural cure" for a chronic infection or the induction of protective immunity against this agent. At the same time, new viral diseases of humans and animals continue to emerge or re-emerge, due to changes in host susceptibility and/or in virus virulence as well as to re-introduction of a virus that had disappeared from a defined population. These changes, at least in part, may appear as a consequence of antiviral therapies and lead to the selection of viral mutants. Moreover, taking into account that viruses have been studied as causative agents of conspicuous diseases a broad spectrum of uncertainty is still present when unapparent persistent infections are considered. Based on Hippocrates (460-357 b.C.E) natural philosophy, "Natura Morborum Medicatrix" which represents the natural healing force, i.e.: "Nature cures diseases"; and "Similia Similibus Curantur" which means "like cure like", we propose the use of natural compounds with chemical structures similar to cellular membrane components. On this approach, sulfated polysaccharides obtained from marine algae may act as a driving force for the emergence of attenuated viruses, enabling this way a practical approach for preventive therapies for herpes simplex virus infection. At the same time, viruses would be creative tools and their contribution by adding new genetic identity to their host are set points of genesis in the growth of the tree of life.
authors.affiliation: Departamento de Química Biológica, Laboratorio de Virología, Pabellón 2, Piso 4, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina. majoc@qb.fcen.uba.ar
authors.forename: M J
authors.initials: MJ
authors.lastname: Carlucci
authors.forename: E B
authors.initials: EB
authors.lastname: Damonte
authors.forename: L A
authors.initials: LA
authors.lastname: Scolaro
mesh_terms: D000818:Animals; D005075:Biological Evolution; D054884:Host-Pathogen Interactions; D006801:Humans; D014777:Virus Diseases / Q000276:immunology*; D014780:Viruses / Q000276:immunology