title: miR-210: More than a silent player in hypoxia.
abstract: Multiple studies have consistently established that miR (microRNA)-210 induction is a feature of the hypoxic response in both normal and transformed cells. Here, we discuss the emerging biochemical functions of this miRNA and anticipate potential clinical applications. miR-210 is a robust target of hypoxia-inducible factor, and its overexpression has been detected in a variety of cardiovascular diseases and solid tumors. High levels of miR-210 have been linked to an in vivo hypoxic signature and associated with adverse prognosis in cancer patients. A wide spectrum of miR-210 targets have been identified, with roles in mitochondrial metabolism, angiogenesis, DNA repair, and cell survival. Such targets may broadly affect the evolution of tumors and other pathological settings, such as ischemic disorders. Harnessing the knowledge of miR-210's actions may lead to novel diagnostic and therapeutic approaches.
authors.affiliation: Department of Medicine, Indiana University, Indianapolis, IN, USA.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Devlin
authors.forename: Simona
authors.initials: S
authors.lastname: Greco
authors.forename: Fabio
authors.initials: F
authors.lastname: Martelli
authors.forename: Mircea
authors.initials: M
authors.lastname: Ivan
mesh_terms: D000818:Animals; D017209:Apoptosis; D015415:Biomarkers / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism; D015687:Cell Hypoxia / Q000235:genetics; D045744:Cell Line, Tumor; D002470:Cell Survival; D004260:DNA Repair; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism*; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics; D008928:Mitochondria / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress; D011379:Prognosis
chemical_list: D015415:Biomarkers; D051793:Hypoxia-Inducible Factor 1; D035683:MicroRNAs