title: Early immunopathology events in simian retrovirus, type 2 infections prior to the onset of disease.
abstract: Immunopathology during early simian retrovirus type 2 (SRV-2) infection is poorly characterized. Here, viral dynamics, immune response and disease progression in transiently- or persistently-infected cynomolgus macaques are assessed. Viral nucleic acids were detected in selected lymphoid tissues of both persistently- and transiently-infected macaques, even after viral clearance from the periphery. Immunohistochemical staining of lymphoid tissues revealed alterations in a number of immune cell populations in both transiently- and persistently-infected macaques. The precise pattern depended upon the infection status of the macaque and the marker studied. Gross immunopathological changes in lymphoid tissues were similar between SRV infection and those observed for other simian retroviruses SIV and STLV, suggesting a common immunopathological response to infection with these agents.
authors.affiliation: Division of Retrovirology, National Institute for Biological Standards and Control, A Centre of the Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. Jane.Mitchell@nibsc.hpa.org.uk
authors.forename: Jane L
authors.initials: JL
authors.lastname: Mitchell
authors.forename: Claire K
authors.initials: CK
authors.lastname: Murrell
authors.forename: Ghazi
authors.initials: G
authors.lastname: Auda
authors.forename: Neil
authors.initials: N
authors.lastname: Almond
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Rose
mesh_terms: D000818:Animals; D004279:DNA, Viral; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology / Q000821:virology; D008252:Macaca fascicularis; D016093:Mason-Pfizer monkey virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D008643:Mesentery / Q000473:pathology; D008992:Monkey Diseases / Q000276:immunology* / Q000473:pathology / Q000821:virology; D012192:Retroviridae Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D013154:Spleen / Q000276:immunology / Q000473:pathology / Q000821:virology; D014412:Tumor Virus Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D019562:Viral Load
chemical_list: D004279:DNA, Viral