title: Feeble awake effects of plasminogen activator inhibitor type-1 in mice.
abstract: Plasminogen activator inhibitor-type 1 (PAI-1) is involved in the fibrinolytic system and shows its increased levels in diseases, e.g., obesity and sleep apnea syndrome. The aim of the study is to investigate whether PAI-1 affects sleep-wake patterns in mice. When recombinant mouse PAI-1 was administered intraperitoneally, only rapid but short increases in time spent awake were observed after 20 or 100 μg/kg, although its plasma concentration was kept high for an hour. The results suggest that PAI-1 may serve its role rather as a marker than an initiator of disturbed sleep.
authors.affiliation: Institute for Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakakibara
authors.forename: Christoph P N
authors.initials: CP
authors.lastname: Romanowski
authors.forename: Vladimira
authors.initials: V
authors.lastname: Jakubcakova
authors.forename: Cornelia
authors.initials: C
authors.lastname: Flachskamm
authors.forename: Kayoko
authors.initials: K
authors.lastname: Shimoi
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kimura
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D058256:Brain Waves / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography / Q000379:methods; D007274:Injections, Intraperitoneal / Q000379:methods; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000494:pharmacology*; D012890:Sleep; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects*
chemical_list: D017395:Plasminogen Activator Inhibitor 1