title: Hematopoietic cell regulation of osteoblast proliferation and differentiation.
abstract: The last several decades have revealed numerous interactions between cells of the hematopoietic lineage and osteoblasts (OBs) of the mesenchymal lineage. For example, OBs are important players in the hematopoietic stem cell (HSC) niche and OBs are known to impact osteoclast (OC) development. Thus, although much is known regarding the impact OBs have on hematopoietic cells, less is known about the impact of hematopoietic cells on OBs. Here we will review this reciprocal relationship: the effects of hematopoietic cells on OBs. Specifically, we will examine the impact of hematopoietic cells such as HSCs, lymphocytes, and megakaryocytes, as well as the hematopoietic cell-derived OCs on OB proliferation, differentiation, and function.
authors.affiliation: Department of Orthopaedic Surgery, Indiana University School of Medicine, 1120 South Drive, FH 115, Indianapolis, IN 46202, USA. mobethel@iupui.edu
authors.forename: Monique
authors.initials: M
authors.lastname: Bethel
authors.forename: Edward F
authors.initials: EF
authors.lastname: Srour
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Kacena
mesh_terms: D000818:Animals; D015519:Bone Density; D002450:Cell Communication; D002454:Cell Differentiation; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D008533:Megakaryocytes / Q000187:drug effects / Q000502:physiology; D051379:Mice; D010006:Osteoblasts / Q000502:physiology*; D010010:Osteoclasts / Q000502:physiology