title: [Methemoglobinemia in patients with Plasmodium vivax receiving oral therapy with primaquine].
abstract: BACKGROUND
  Primaquine can produce adverse reactions as toxicity to blood when used in the treatment of vivax malaria. This work aimed to determine methemoglobinemia in patients with vivax malaria receiving oral therapy with primaquine.
  
  
  METHODS
  Spectrophotometric quantification of methemoglobinemia and qualitative assay for glucose-6-phosphate dehydrogenase.
  
  
  RESULTS
  Methemoglobinemia ranged from 2.85 to 5.45% in male patients and 3.77 to 7.34% in female patients.
  
  
  CONCLUSIONS
  A statistically significant increase in methemoglobinemia was observed following oral therapy with primaquine, with no clinical manifestations, and independent of sex and the qualitative expression of glucose-6-phosphate dehydrogenase.
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, Belém, PA.
authors.forename: Michelli Erica Souza
authors.initials: ME
authors.lastname: Ferreira
authors.forename: Margarete do Socorro Mendonça
authors.initials: Mdo S
authors.lastname: Gomes
authors.forename: José Luiz Fernandes
authors.initials: JL
authors.lastname: Vieira
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006801:Humans; D016780:Malaria, Vivax / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced*; D008875:Middle Aged; D011319:Primaquine / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D012737:Sex Factors; D013053:Spectrophotometry; D055815:Young Adult
chemical_list: D000962:Antimalarials; D005954:Glucosephosphate Dehydrogenase; D011319:Primaquine