title: Gait variability is associated with frailty in community-dwelling older adults.
abstract: BACKGROUND
  The relationship between frailty and gait characteristics other than velocity has received little attention. Gait variability quantifies the automaticity of gait with greater variability usually indicating an irregular and unstable gait. High gait variability reflects the loss of gait regulation and predicts mobility decline and falls, which may reveal systemic vulnerability. Thus, we hypothesize that high gait variability may be associated with frailty phenotype.
  
  
  METHODS
  Cross-sectional study including 100 community-dwelling women and men 75 years and older. Frailty was defined using validated phenotypic criteria and two additional frailty indexes that omit gait velocity criterion were used to verify associations between frailty and quantitative gait parameters. Gait was assessed under usual and fast pace using an electronic walkway.
  
  
  RESULTS
  Frailty phenotype was identified in 20% of the participants and at least one component of frailty was present in 75%. Linear regression models were generated to explore the associations between frailty and gait variability. In the univariate regression model, frailty was associated with higher variability for all the gait parameters of interest. After adjustments, stride time variability under fast gait condition was the most prominent parameter consistently associated with frailty. This association remained significant in two additional frailty indexes that omit gait velocity criterion.
  
  
  CONCLUSIONS
  Frailty is associated with low performance in several quantitative gait parameters beyond velocity of which the most prominent is high stride time variability. This finding may help to understand the high risk of falls and mobility decline in people with frailty.
authors.affiliation: Department of Medicine, Division of Geriatric Medicine, The University of Western Ontario, London, Ontario, Canada. mmontero@uwo.ca
authors.forename: Manuel
authors.initials: M
authors.lastname: Montero-Odasso
authors.forename: Susan W
authors.initials: SW
authors.lastname: Muir
authors.forename: Maggie
authors.initials: M
authors.lastname: Hall
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Doherty
authors.forename: Marita
authors.initials: M
authors.lastname: Kloseck
authors.forename: Olivier
authors.initials: O
authors.lastname: Beauchet
authors.forename: Mark
authors.initials: M
authors.lastname: Speechley
mesh_terms: D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D016330:Frail Elderly; D005684:Gait / Q000502:physiology*; D006801:Humans; D057187:Independent Living; D008297:Male