title: Effects of ambient particulate matter and fungal spores on lung function in schoolchildren.
abstract: OBJECTIVE
  Studies examining the combined health effects of both have been relatively lacking. We conducted a longitudinal study to investigate whether exposure to air pollutants and fungal spores might exacerbate childhood respiratory health.
  
  
  METHODS
  Study participants were 100 elementary and middle-school students in Taipei County, Taiwan. A structured respiratory health questionnaire was administered in September 2007, followed by monthly spirometry from October 2007 to June 2008. During the study period, complete daily monitoring data for criteria air pollutants were obtained from the Environmental Protection Administration monitoring station and Aerosol Supersite. Fungal spores were measured from Sunday to Saturday in the week when lung-function measurements were made for each study month. Lung-function measurements were compared with air pollutants and fungal spores using mixed-effects models with 1-day-lag modeling.
  
  
  RESULTS
  The particulate matter with an aerodynamic diameter of 2.5 μm or less level 1 day before the lung function measurements was negatively associated with forced vital capacity. The fungal spore level was negatively associated with both forced expiratory vital capacity and forced expiratory volume in 1 second. O(3) level was negatively associated with forced expiratory flow at 25%, 50%, and 75% of forced vital capacity, and average expiratory flow over the middle half of forced vital capacity.
  
  
  CONCLUSIONS
  This study suggested that exposure to particulate matter with an aerodynamic diameter of 2.5 μm or less and fungal spores might cause adverse effects on the vital capacity of schoolchildren. Exposure to O(3) adversely affected small airway function.
authors.affiliation: Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei, Taiwan.
authors.forename: Bing-Yu
authors.initials: BY
authors.lastname: Chen
authors.forename: H Jasmine
authors.initials: HJ
authors.lastname: Chao
authors.forename: Chang-Chuan
authors.initials: CC
authors.lastname: Chan
authors.forename: Chung-Te
authors.initials: CT
authors.lastname: Lee
authors.forename: Hung-Pin
authors.initials: HP
authors.lastname: Wu
authors.forename: Tsun-Jen
authors.initials: TJ
authors.lastname: Cheng
authors.forename: Chu-Chih
authors.initials: CC
authors.lastname: Chen
authors.forename: Yue Leon
authors.initials: YL
authors.lastname: Guo
mesh_terms: D002648:Child; D004781:Environmental Exposure / Q000009:adverse effects*; D004784:Environmental Monitoring; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D052638:Particulate Matter / Q000009:adverse effects*; D012189:Retrospective Studies; D013147:Spirometry; D013172:Spores, Fungal; D013624:Taiwan; D014797:Vital Capacity / Q000187:drug effects / Q000502:physiology*
chemical_list: D052638:Particulate Matter