title: Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis.
abstract: BACKGROUND
  The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients.
  
  
  METHODS
  We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs.
  
  
  RESULTS
  Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase.
  
  
  CONCLUSIONS
  Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.
authors.affiliation: Department of Neurology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Toyoake, Aichi, Japan.
authors.forename: Madoka
authors.initials: M
authors.lastname: Kizawa-Ueda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ueda
authors.forename: Naoki
authors.initials: N
authors.lastname: Kawamura
authors.forename: Tomomasa
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Eri
authors.initials: E
authors.lastname: Mutoh
authors.forename: Yu
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Shiroki
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Hoshinaga
authors.forename: Shinji
authors.initials: S
authors.lastname: Ito
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Asakura
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Mutoh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000134:cerebrospinal fluid*; D004660:Encephalitis / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid*; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000134:cerebrospinal fluid*; D020933:Neurotrophin 3 / Q000134:cerebrospinal fluid*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D020933:Neurotrophin 3; D020932:Nerve Growth Factor