title: Should colloid boluses be prioritized over crystalloid boluses for the management of dengue shock syndrome in the presence of ascites and pleural effusions?
abstract: BACKGROUND
  Although the WHO guideline for the management of dengue fever considers the presence of ascites or pleural effusions in the diagnosis of DSS, it does not emphasize the importance of their presence when selecting fluids for resuscitation.
  
  
  METHODS
  We highlight three patients with DSS who received boluses of crystalloids on priority basis as recommended by WHO guidelines during resuscitation. All three patients had varying degrees of third space fluid loss (ascites and pleural effusions) at the time of development of DSS. Ascites and pleural effusions were detected in all 3 patients at the time of shock irrespective of whether iv fluids were given or not. All three patients had documented liver involvement at the time of shock evidenced by elevation of AST (4800 iu/L, 5000 iu/L and 1960 iu/L). One patient who had profound shock died 6 hours after admission with evidence of acute pulmonary oedema in the convalescence phase. All of them needed CPAP ventilator support and potent diuretics.
  
  
  CONCLUSIONS
  We therefore feel that resuscitation of patients with DSS who already have third space fluid accumulation with crystalloid boluses on priority basis may contribute to recovery phase pulmonary oedema.
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Kelaniya, Sri Lanka. ranjan_premaratna@lycos.com
authors.forename: Ranjan
authors.initials: R
authors.lastname: Premaratna
authors.forename: Erandi
authors.initials: E
authors.lastname: Liyanaarachchi
authors.forename: Mindu
authors.initials: M
authors.lastname: Weerasinghe
authors.forename: H Janaka
authors.initials: HJ
authors.lastname: de Silva
mesh_terms: D000328:Adult; D001201:Ascites / Q000150:complications*; D004358:Drug Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D010996:Pleural Effusion / Q000150:complications*; D019595:Severe Dengue / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome