title: Thirteen-year prospective study between fish consumption, long-chain n-3 fatty acids intakes and cognitive function.
abstract: OBJECTIVE
  Because of their structural, anti-inflammatory and antithrombic properties, long-chain n-3 fatty acids may be key factors in the aging process. We sought to elucidate the association between intake of long-chain n-3 fatty acids and/or fish and cognitive function evaluated 13 years after dietary assessment.
  
  
  METHODS
  Prospective population-based study.
  
  
  METHODS
  3,294 adults from the SU.VI.MAX study (Supplementation with Antioxidant Vitamins and Minerals study). MEASUREMENTS/STATISTICAL ANALYSIS: Subjects underwent a standardized clinical examination which included cognitive tests and self-reported cognitive difficulties scale (2007-2009). Poor scores were defined using percentiles as cut-off. Dietary data were assessed through repeated 24-h dietary records. Odd ratio (OR), comparing the fourth (Q4) to the first quartile (Q1), of having a poor score were calculated using adjusted logistic regression.
  
  
  RESULTS
  Self-reported cognitive difficulties were less frequent among subjects with higher intakes of total n-3 long chain fatty acids (OR = 0.72, CI 95%=0.56-0.92) and eicosapentaenoic acid (OR Q4 versus Q1 = 0.74, CI 95%=0.58-0.95), even after adjustment for depressive symptoms. A borderline significant association was also found with high fish consumption (OR Q4 versus Q1 = 0.80, CI 95%=0.63-1.01).
  
  
  CONCLUSIONS
  Cognitive complaints, which may be an early indicator of cognitive decline, are less frequent among the elderly who have a high long-chain n-3 acids intake, as assessed 13 years earlier.
authors.affiliation: INSERM U557, INRA U1125, CNAM, PARIS 13, Human Nutrition Research Center of Ile de France, UFR SMBH Paris 13, SMBH, Bobigny, France. e.kesse@uren.smbh.univ-paris13.fr
authors.forename: E
authors.initials: E
authors.lastname: Kesse-Guyot
authors.forename: S
authors.initials: S
authors.lastname: Péneau
authors.forename: M
authors.initials: M
authors.lastname: Ferry
authors.forename: C
authors.initials: C
authors.lastname: Jeandel
authors.forename: S
authors.initials: S
authors.lastname: Hercberg
authors.forename: P
authors.initials: P
authors.lastname: Galan
mesh_terms: D000368:Aged; D000375:Aging / Q000523:psychology*; D000818:Animals; D003071:Cognition / Q000187:drug effects* / Q000502:physiology*; D003072:Cognition Disorders / Q000453:epidemiology; D004034:Diet Surveys; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005247:Feeding Behavior; D005260:Female; D005399:Fishes; D005602:France; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D017747:Seafood
chemical_list: D015525:Fatty Acids, Omega-3