title: [Expression and clinical significance of epidermal growth factor receptor and protein kinase B in gastric carcinoma].
abstract: OBJECTIVE
  To evaluate the association between survival and expressions of epidermal growth factor receptor(EGFR) and protein kinase B(AKT) in gastric carcinoma specimens.
  
  
  METHODS
  EGFR and AKT were detected by immunohistochemistry in 84 patients with gastric cancer and 15 controls. Association between their expressions and clinical characteristics as well as prognosis were analyzed.
  
  
  RESULTS
  In patients with gastric cancer,expression rates were significantly higher than those in 15 normal gastric tissues for EGFR(55.9% vs. 20%, P<0.05) and AKT(64.3% vs. 6.7%, P<0.01). Expression of EGFR was associated with late staging(P<0.01), while expression of AKT was associated with lymph node metastasis(P<0.01). Overall 5-year survival rate was significantly higher in patients with EGFR negative expression (49.0% vs. 22.0%, P<0.05). Overall 5-year survival rate was significantly higher in patients with AKT expression(45.7% vs. 30.2%, P<0.05).
  
  
  CONCLUSIONS
  Expression of EGFR and AKT negative may be used to evaluate the degree of differentiation and prognosis in patients with gastric carcinoma.
authors.affiliation: Department of Medical Oncology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China. zdwyzhy@163.com
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Zhang
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Tao
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D066246:ErbB Receptors; D051057:Proto-Oncogene Proteins c-akt