title: Plasma levels of leptin and orexin A in the restrictive type of anorexia nervosa.
abstract: OBJECTIVE
  The aim of the study was to analyze the pattern of leptin and orexin A plasma levels in patients with the restrictive type of anorexia nervosa (AN-R), during the course of treatment. Thirty females with AN-R, aged 18.0 ± 1.6 years (mean ± SD), range of 15.5-21.0 years, were investigated before and after 2, 3, and 6 months of treatment, which included a normocaloric diet and cognitive-behavioral psychotherapy. The control group consisted of 20 age-matched, healthy control females.
  
  
  RESULTS
  Before the therapy, both leptin and orexin A plasma levels were significantly lower than in the control group and were negatively correlated. During treatment, leptin levels increased and, after 6 months, showed a correlation with body mass index (BMI). Orexin A levels showed a further decrease during treatment, with no correlation with BMI.
  
  
  CONCLUSIONS
  The results corroborate those of other researchers showing a decrease of leptin levels in patients with AN-R and its increase with body mass increment. They may also suggest a possible relationship between leptin and orexin A plasma level patterns in such patients.
authors.affiliation: Department and Clinic of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland. mkozik@centrum-pediatrii.com.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Janas-Kozik
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Stachowicz
authors.forename: Irena
authors.initials: I
authors.lastname: Krupka-Matuszczyk
authors.forename: Jan
authors.initials: J
authors.lastname: Szymszal
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Krysta
authors.forename: Adam
authors.initials: A
authors.lastname: Janas
authors.forename: Janusz K
authors.initials: JK
authors.lastname: Rybakowski
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000523:psychology / Q000628:therapy; D015992:Body Mass Index; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D020738:Leptin / Q000097:blood*; D009479:Neuropeptides / Q000097:blood*; D000068797:Orexins; D055815:Young Adult
chemical_list: C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin; D009479:Neuropeptides; D000068797:Orexins