title: Triggered release from liposomes through magnetic actuation of iron oxide nanoparticle containing membranes.
abstract: The ideal nanoscale drug delivery vehicle allows control over the released dose in space and time. We demonstrate that this can be achieved by stealth liposomes comprising self-assembled superparamagnetic iron oxide nanoparticles (NPs) individually stabilized with palmityl-nitroDOPA incorporated in the lipid membrane. Alternating magnetic fields were used to control timing and dose of repeatedly released cargo from such vesicles by locally heating the membrane, which changed its permeability without major effects on the environment.
authors.affiliation: Laboratory for Surface Science and Technology, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland.
authors.forename: Esther
authors.initials: E
authors.lastname: Amstad
authors.forename: Joachim
authors.initials: J
authors.lastname: Kohlbrecher
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Müller
authors.forename: Thomas
authors.initials: T
authors.lastname: Schweizer
authors.forename: Marcus
authors.initials: M
authors.lastname: Textor
authors.forename: Erik
authors.initials: E
authors.lastname: Reimhult
mesh_terms: D004574:Electromagnetic Fields; D005290:Ferric Compounds / Q000737:chemistry* / Q000528:radiation effects; D008081:Liposomes / Q000737:chemistry* / Q000528:radiation effects*; D008422:Materials Testing; D008567:Membranes, Artificial; D053769:Nanocapsules / Q000737:chemistry* / Q000528:radiation effects*; D010539:Permeability / Q000528:radiation effects; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; D008081:Liposomes; D008567:Membranes, Artificial; D053769:Nanocapsules; D004364:Pharmaceutical Preparations; C000499:ferric oxide