title: Extraluminal factors contributing to inflammatory bowel disease.
abstract: Many identified and yet unknown factors contribute to the pathogenesis of inflammatory bowel disease (IBD). The genome-wide association studies clearly support the earlier developed concept that IBD occurs in genetically predisposed individuals who are exposed to distinct environmental factors, which together result in dysregulation of the mucosal immune system. Thus, the majority of previous studies have focused on the immune response within the intestinal wall. The present review aims to emphasize the contribution of three extraluminal structures to this inflammatory process, namely the mesenteric fat tissue, the lymphatics and the microvasculature. Broadening our view across the intestinal wall will not only facilitate our understanding of the disease, but will also us to identify future therapeutic targets.
authors.affiliation: Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Medical Department I, Gastroenterology/Rheumatology/Infectious Diseases, Hindenburgdamm 30, 12200 Berlin, Germany.
authors.forename: Arvind
authors.initials: A
authors.lastname: Batra
authors.forename: Thorsten
authors.initials: T
authors.lastname: Stroh
authors.forename: Britta
authors.initials: B
authors.lastname: Siegmund
mesh_terms: D017667:Adipocytes / Q000276:immunology; D054392:Adipokines / Q000276:immunology; D000273:Adipose Tissue / Q000166:cytology / Q000276:immunology / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D008208:Lymphatic System / Q000033:anatomy & histology / Q000276:immunology; D008643:Mesentery / Q000033:anatomy & histology / Q000276:immunology / Q000473:pathology; D008833:Microcirculation / Q000276:immunology
chemical_list: D054392:Adipokines