title: Impact of clinical parameters on the diagnostic accuracy of endorectal coil MRI for the detection of prostate cancer.
abstract: OBJECTIVE
  Endorectal coil MRI (endoMRI) of the prostate is useful to evaluate tumor localization. There is little evidence on patient characteristics affecting its diagnostic performance. We evaluate the influence of clinical and histological parameters on the accuracy of endoMRI.
  
  
  METHODS
  Sixty-nine patients with prostate cancer were included. After virtually dividing the prostate into pixels of 1 cm2, results of endoMRI were compared with those from prostatectomy specimens' whole-mount sections. Univariate and multivariate analyses were performed to calculate the impact of clinical and histological parameters on the number of appropriately described pixels.
  
  
  RESULTS
  In 9, no tumor could be demonstrated by endoMRI. 48.3% of patients were staged correctly, 23.3% were over- and 28.3% understaged. Mean rates of correctly labeled pixels were 0.44 (± 0.04 SEM) for tumor and 0.90 (± 0.01) for benign segments. In univariate analysis, the rate of correctly labeled tumor segments showed significant positive correlations with Gleason score ≥7 and negative correlations with prostate weight and multifocality. The rate of correctly labeled benign segments showed significant negative correlation with tumor weight. All factors were independent variables in multivariate analysis.
  
  
  CONCLUSIONS
  The reliability of endoMRI depends on clinical parameters. Higher Gleason scores, unifocal tumors and smaller prostate volumes ameliorate endoMRI performance.
authors.affiliation: Department of Urology, Eberhard Karls University Tübingen, Tübingen, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Colleselli
authors.forename: Jörg
authors.initials: J
authors.lastname: Hennenlotter
authors.forename: David
authors.initials: D
authors.lastname: Schilling
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Krueger
authors.forename: Mathias
authors.initials: M
authors.lastname: Roethke
authors.forename: Mathias P
authors.initials: MP
authors.lastname: Lichy
authors.forename: Ullrich
authors.initials: U
authors.lastname: Vogel
authors.forename: Ursula
authors.initials: U
authors.lastname: Kuehs
authors.forename: Heinz-Peter
authors.initials: HP
authors.lastname: Schlemmer
authors.forename: Arnulf
authors.initials: A
authors.lastname: Stenzl
authors.forename: Christian
authors.initials: C
authors.lastname: Schwentner
mesh_terms: D000368:Aged; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D009929:Organ Size; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000096:biosynthesis; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology*
chemical_list: D017430:Prostate-Specific Antigen