title: Ground-glass nodules on chest CT as imaging biomarkers in the management of lung adenocarcinoma.
abstract: OBJECTIVE
  The purpose of this article is to review the clinical significance of ground-glass nodules (GGNs) in the management of lung adenocarcinoma.
  
  
  CONCLUSIONS
  GGNs can serve as imaging biomarkers that represent the bronchioloalveolar carcinoma component in adenocarcinoma on histology and indicate a better prognosis in patients with lung adenocarcinoma. The evolution of GGNs reflects the multistep progression of adenocarcinoma. Despite the high probability of malignancy of GGNs, the possibility of overdiagnosis should be considered in the management of GGNs.
authors.affiliation: Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, Daehangno, Jongno-gu, Korea. jmgoo@plaza.snu.ac.kr
authors.forename: Jin Mo
authors.initials: JM
authors.lastname: Goo
authors.forename: Chang Min
authors.initials: CM
authors.lastname: Park
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D001706:Biopsy; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D017410:Practice Guidelines as Topic; D011379:Prognosis; D013902:Radiography, Thoracic / Q000379:methods; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*