title: Determination of 14 monoalkyl phosphates, dialkyl phosphates and dialkyl thiophosphates by LC-MS/MS in human urinary samples.
abstract: Human urine was analyzed for nine dialkyl (DAP) and five monoalkyl phosphates (MAP) by LC-MS/MS. Some phosphoric acid esters are industrial chemicals and other hydrolysis products of trialkyl or triaryl phosphates, used as pesticides, flame retardants or plasticizers. Five MAP and two DAP were detected here for the first time in human urine. Monobutyl, diethyl, diphenyl and diethylhexyl phosphate were determined with median concentrations in the μg/L-range. The total urinary concentration of the 14 DAP and MAP summed up to a median of 20μg/L. Inclusion of MAP in future biomonitoring studies should provide a more comprehensive picture of the exposure of humans to organophosphorus compounds.
authors.affiliation: Technical University of Berlin, Department of Water Quality Control, Sekr KF 4, Strasse des 17 Juni 135, 10623 Berlin, Germany. thorsten.reemtsma@ufz.de
authors.forename: Thorsten
authors.initials: T
authors.lastname: Reemtsma
authors.forename: Jana
authors.initials: J
authors.lastname: Lingott
authors.forename: Stefanie
authors.initials: S
authors.lastname: Roegler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002853:Chromatography, Liquid; D004784:Environmental Monitoring / Q000379:methods; D004785:Environmental Pollutants / Q000737:chemistry / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000737:chemistry / Q000652:urine*; D053719:Tandem Mass Spectrometry; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D010710:Phosphates; C035638:thiophosphoric acid