title: Texaphyrins: tumor localizing redox active expanded porphyrins.
abstract: Texaphyrins, a class of tumor selective expanded porphyrins capable of coordinating large metals, have been found to act as redox mediators within biological systems. This review summarizes studies involving their experimental use in cancer chemotherapy. Mechanistic insights involving their presumed mode of action are also described, as well as certain structure activity relationships. Finally, newer texaphyrin-based applications associated with targeted drug delivery are presented.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712-0165, USA.
authors.forename: Jonathan F
authors.initials: JF
authors.lastname: Arambula
authors.forename: Christian
authors.initials: C
authors.lastname: Preihs
authors.forename: Derric
authors.initials: D
authors.lastname: Borthwick
authors.forename: Darren
authors.initials: D
authors.lastname: Magda
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Sessler
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010084:Oxidation-Reduction; D011166:Porphyrins / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D011166:Porphyrins; C442892:texaphyrin