title: Long-term rabbits bone response to titanium implants in the presence of inorganic bovine-derived graft.
abstract: This study evaluated bone responses to titanium implants in the presence of an inorganic graft material. The bilateral mandible incisors of 24 rabbits were surgically extracted and one of the exposed sockets, chosen at random, was filled with an inorganic xenogenic bone graft (Gen-ox®), whereas the remaining socket was left to heal naturally and served as a control. After 60 days, titanium implants were inserted in the specific areas, and on days 0, 30, 60, and 180 after the implant insertions, six animals of each group were killed. Digital periapical radiography of implant region was obtained and vertical bone height (VBH) and bone density (BD) were evaluated by digital analysis system. In the undecalcified tissue cuts, bone-to-implant contact (BIC) and bone area (BA) within the limits of the implant threads were evaluated and compared statistically by means of two-way ANOVA and Tukey's test (ρ < 0.05). No significant differences were detected in VBH and BA, either between groups or between different experimental intervals. The BD was significantly higher in the experimental group than in the control group in all the intervals tested, but there were no significant differences by interval. The BIC was statistically lower in the control group on day 0; however, a significant increase was observed on days 60 and 180 (ρ < 0.05). The use of an inorganic xenograft prior to insertion of a titanium implant did not interfere with the course of osseointegration.
authors.affiliation: Department of Stomatology and Oral Surgery, School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. etiamfob@yahoo.com
authors.forename: Etiene Andrade
authors.initials: EA
authors.lastname: Munhoz
authors.forename: Augusto
authors.initials: A
authors.lastname: Bodanezi
authors.forename: Tania Mary
authors.initials: TM
authors.lastname: Cestari
authors.forename: Rumio
authors.initials: R
authors.lastname: Taga
authors.forename: Paulo Sergio Perri
authors.initials: PS
authors.lastname: de Carvalho
authors.forename: Osny
authors.initials: O
authors.lastname: Ferreira
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001705:Bioprosthesis; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000502:physiology*; D002417:Cattle; D008297:Male; D019736:Prostheses and Implants; D011817:Rabbits; D011859:Radiography; D014025:Titanium
chemical_list: D014025:Titanium