title: [Tremorgenic syndrome in a cattle herd after feeding silage contaminated with A. clavatus].
abstract: The clinical signs, pathological and laboratory findings of cattle suffering from a tremorgenic syndrome are described. Animals on a farm with a total of 22 cows, 18 heifers and 9 calves were fed mouldy grass and spent malt-grain silage. Five heifers were affected with muscular tremor, hyperexcitability and hypersensitivity. They were ataxic or in sternal recumbency, while their appetite remained normal. Haematology and blood chemistry in two heifers as well as cerebrospinal fluid from one sick animal were unremarkable. The pathological examination of one animal brought no macroscopic changes to light. Histological examination, however, revealed the degeneration of motor neurones in the midbrain, brain stem and spinal cord. Analysis of a silage sample provided evidence of the presence of Aspergillus clavatus, a mould capable of producing neurotoxic tremorgenic mycotoxins. Epidemiology, clinical findings, pathology and microbiological examination suggest that the five cattle were suffering from neuromycotoxicosis.
authors.affiliation: Wiederkäuerklinik der Universität Bern, Bern.
authors.forename: M
authors.initials: M
authors.lastname: Niederberger
authors.forename: A
authors.initials: A
authors.lastname: Oevermann
authors.forename: F
authors.initials: F
authors.lastname: Kirscher
authors.forename: M
authors.initials: M
authors.lastname: Meylan
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000302:isolation & purification* / Q000378:metabolism; D001259:Ataxia / Q000662:veterinary; D001933:Brain Stem / Q000473:pathology; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D008636:Mesencephalon / Q000473:pathology; D009046:Motor Neurons / Q000473:pathology; D015651:Mycotoxicosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D009498:Neurotoxins / Q000096:biosynthesis / Q000506:poisoning*; D006109:Poaceae / Q000382:microbiology; D012820:Silage / Q000382:microbiology* / Q000506:poisoning; D013116:Spinal Cord / Q000473:pathology; D013577:Syndrome; D014202:Tremor / Q000209:etiology / Q000473:pathology / Q000662:veterinary*
chemical_list: D009498:Neurotoxins