title: Cytotoxic T cells - stroma interactions.
abstract: The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells.
authors.affiliation: Inserm, PR1 and IFR, laboratoire d’immunologie des tumeurs humaines : interaction effecteurs cytotoxiques-système tumoral, Institut Gustave-Roussy, Villejuif, France. noman@igr.fr
authors.forename: Muhammad Zaeem
authors.initials: MZ
authors.lastname: Noman
authors.forename: Houssem
authors.initials: H
authors.lastname: Benlalam
authors.forename: Meriem
authors.initials: M
authors.lastname: Hasmim
authors.forename: Salem
authors.initials: S
authors.lastname: Chouaib
mesh_terms: D017951:Antigen Presentation / Q000502:physiology; D002450:Cell Communication / Q000276:immunology / Q000502:physiology*; D015687:Cell Hypoxia / Q000276:immunology / Q000502:physiology*; D018450:Disease Progression; D042783:Endothelial Cells / Q000276:immunology / Q000502:physiology*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology / Q000502:physiology; D008545:Melanoma / Q000276:immunology; D009363:Neoplasm Proteins / Q000502:physiology*; D050796:STAT3 Transcription Factor / Q000502:physiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000502:physiology*; D059016:Tumor Microenvironment / Q000276:immunology / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009363:Neoplasm Proteins; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D042461:Vascular Endothelial Growth Factor A