title: Synthesis of β-amino acid derivatives via copper-catalyzed asymmetric 1,4-reduction of β-(acylamino)acrylates.
abstract: A new set of reaction conditions has been established to facilitate the copper-catalyzed enantioselective 1,4-reduction of β-(acylamino)acrylates toward a selection of β-alkyl-β-amino acid derivatives in high yields and with uniformly high ee values (up to 99%) irrespective of the use of (E)- or (Z)-substrates.
authors.affiliation: College of Material, Chemistry and Chemical Engineering and Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Shan-Bin
authors.initials: SB
authors.lastname: Qi
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Wu
authors.forename: Xi-Chang
authors.initials: XC
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D000596:Amino Acids; D008024:Ligands; D003300:Copper