title: Single atom modification leads to enhanced nucleotide self-assembly: the role of cation bridging.
abstract: We report that the ability of disodium 5'-deoxy-5'-thioguanosine-5'-monophosphate, Na(2)(5'-GSMP), to self-associate into a helical G-quadruplex structure in aqueous solution at pH 8 is significantly higher than that of disodium guanosine-5'-monophosphate, Na(2)(5'-GMP), which supports our earlier hypothesis regarding the importance of cation bridging.
authors.affiliation: Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6.
authors.forename: Irene C M
authors.initials: IC
authors.lastname: Kwan
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Delley
authors.forename: David R W
authors.initials: DR
authors.lastname: Hodgson
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
mesh_terms: D002412:Cations / Q000737:chemistry; D054856:G-Quadruplexes; D006151:Guanosine / Q000031:analogs & derivatives*; D006157:Guanosine Monophosphate / Q000737:chemistry*
chemical_list: D002412:Cations; D006151:Guanosine; D006157:Guanosine Monophosphate