title: Peculiar surface behavior of some ionic liquids based on active pharmaceutical ingredients.
abstract: The ionic liquids based on biologically active cations and anions, commonly designated by ionic liquids based on active pharmaceutical ingredients (ILs-APIs), are interesting compounds for use in pharmaceutical applications. Lidocaine docusate, ranitidine docusate, and didecyldimethylammonium ibuprofen are examples of promising ILs-APIs that were recently synthesized. They were submitted to biological testing and calorimetric measurements, but nothing is known about their surface properties. In this work, we measured the surface tension and the contact angles on both hydrophilic and hydrophobic surfaces in a temperature range as wide as possible. Based on the wettability data, the polarity fractions were estimated using the Fowkes theory. The peculiar surface behavior observed was tentatively attributed to the presence of mesophases.
authors.affiliation: Centro de Química Estrutural, Instituto Superior Técnico, T U Lisbon, Lisbon, Portugal.
authors.forename: José
authors.initials: J
authors.lastname: Restolho
authors.forename: José Luis
authors.initials: JL
authors.lastname: Mata
authors.forename: Benilde
authors.initials: B
authors.lastname: Saramago
mesh_terms: D004143:Dioctyl Sulfosuccinic Acid / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D008012:Lidocaine / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D011899:Ranitidine / Q000737:chemistry; D013500:Surface Tension; D013696:Temperature
chemical_list: D052578:Ionic Liquids; D004364:Pharmaceutical Preparations; D000644:Quaternary Ammonium Compounds; D004143:Dioctyl Sulfosuccinic Acid; D011899:Ranitidine; D008012:Lidocaine; D007052:Ibuprofen; C027118:didecyldimethylammonium