title: Influence of inflammation on parasitism and area of experimental amoebic liver abscess: an immunohistochemical and morphometric study.
abstract: The influence of inflammation on the number of trophozoites and on the murine amoebic liver abscess area following infection with Entamoeba histolytica and E. dispar was evaluated. Immunohistochemistry and digital morphometry were used to identify and quantify the trophozoites, neutrophils, macrophages, and lesions. Positive correlation was observed between the number of trophozoites and inflammatory cells. A significant decrease in parasitism and inflammation in groups treated with dexamethasone was observed. The scarceness or absence of trophozoites in the treated groups suggest the importance of the inflammatory response in the production of amoebic hepatic abscesses in spite of the inherent virulence of the parasite being decisive in the establishment of the lesion.
authors.affiliation: Programa de Pós-Graduação em Patologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Av, Antônio Carlos 6627, Belo Horizonte, Minas Gerais, Brasil. cassiaaxc@pop.com.br
authors.forename: Cássia Abadia Xavier
authors.initials: CA
authors.lastname: Costa
authors.forename: Thaisa Helena Silva
authors.initials: TH
authors.lastname: Fonseca
authors.forename: Fabrício Marcus Silva
authors.initials: FM
authors.lastname: Oliveira
authors.forename: Joseph Fabiano Guimaraes
authors.initials: JF
authors.lastname: Santos
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: Gomes
authors.forename: Marcelo Vidigal
authors.initials: MV
authors.lastname: Caliari
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001699:Biometry; D003907:Dexamethasone / Q000008:administration & dosage; D004747:Entamoeba / Q000276:immunology* / Q000472:pathogenicity*; D006790:Host-Parasite Interactions; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology / Q000473:pathology*; D008099:Liver / Q000469:parasitology / Q000473:pathology*; D008101:Liver Abscess, Amebic / Q000276:immunology* / Q000473:pathology*; D051379:Mice; D008853:Microscopy
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone