title: A twist on admixture mapping.
abstract: A new study uses genome-wide SNP genotypes to identify a subset of children undergoing therapy for acute lymphoblastic leukemia that are at increased risk for relapse. Borrowing from the classical approach of admixture mapping, the work shows how genome-wide assessment of genetic ancestry can be used as a biomarker for disease outcome.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
mesh_terms: D000306:Adrenal Cortex Neoplasms; D002648:Child; D002874:Chromosome Mapping / Q000379:methods*; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000208:ethnology / Q000235:genetics* / Q000401:mortality*; D025341:Principal Component Analysis; D012008:Recurrence; D012306:Risk