title: Effect of air travel on exercise-induced coagulatory and fibrinolytic activation in marathon runners.
abstract: OBJECTIVE
  Air travel and exercise change hemostatic parameters. This study investigated the effect of air travel on exercise-induced coagulation and fibrinolysis in endurance athletes.
  
  
  METHODS
  A prospective longitudinal study.
  
  
  METHODS
  The 114th Boston Marathon (April 19, 2010).
  
  
  METHODS
  Forty-one adults were divided into travel (T: 23 participants, living >4-hour plane flight from Boston) and nontravel (C: 18 participants, living <2-hour car trip from Boston) groups.
  
  
  METHODS
  Age, anthropometrics, vital signs, training mileage, and finishing time were collected.
  
  
  METHODS
  Subjects provided venous blood samples the day before (PRE), immediately after (FINISH), and the day following the marathon after returning home (POST). Blood was analyzed for thrombin-antithrombin complex (TAT), tissue plasminogen activator (t-PA), hematocrit (Hct), and the presence of Factor V Leiden R506Q mutation.
  
  
  RESULTS
  Thrombin-antithrombin complex increased more in T subjects in PRE to FINISH samples (5.0 ± 4.0 to 12.9 ± 15.6 μg/L) than in C subjects (4.0 ± 1.2 to 6.1 ± 1.2 μg/L; P = 0.02 for comparison). The t-PA increased in both the T (5.4 ± 2.3 to 25.1 ± 12.2 ng/mL) and C (5.6 ± 2.0 to 27.7 ± 11.3 ng/mL) groups in PRE to FINISH samples, and this response did not differ between groups (P = 0.23 for comparison). Both groups exhibited similar t-PA and TAT values at POST that were not different than PRE (all P > 0.35). Age was related to the FINISH TAT values in T (r = 0.19; P = 0.04) but not in C (r = 0.03; P = 0.53) subjects.
  
  
  CONCLUSIONS
  Results suggest that the combination of air travel and marathon running induces an acute hypercoaguable state; this hemostatic imbalance is exaggerated with increasing age.
authors.affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA. bparker03@harthosp.org
authors.forename: Beth
authors.initials: B
authors.lastname: Parker
authors.forename: Amanda
authors.initials: A
authors.lastname: Augeri
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Capizzi
authors.forename: Christopher
authors.initials: C
authors.lastname: Troyanos
authors.forename: Peter
authors.initials: P
authors.lastname: Kriz
authors.forename: Pierre
authors.initials: P
authors.lastname: D'Hemecourt
authors.forename: Paul
authors.initials: P
authors.lastname: Thompson
mesh_terms: D000328:Adult; D000367:Age Factors; D000401:Aircraft; D000990:Antithrombin III; D001777:Blood Coagulation / Q000502:physiology*; D003163:Competitive Behavior / Q000502:physiology; D005165:Factor V / Q000235:genetics; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000097:blood; D010807:Physical Endurance / Q000502:physiology; D011446:Prospective Studies; D012420:Running / Q000502:physiology*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000097:blood; D014195:Travel; D055815:Young Adult
chemical_list: C046193:antithrombin III-protease complex; C095381:factor V Leiden; D000990:Antithrombin III; D005165:Factor V; D010447:Peptide Hydrolases; D010959:Tissue Plasminogen Activator