title: Emerging antibody products and Nicotiana manufacturing.
abstract: Antibody based products are not widely available to address multiple global health challenges due to high costs, limited manufacturing capacity, and long manufacturing lead times. Nicotiana-based manufacturing of antibody products may now begin to address these challenges as a result of revolutionary advances in transient expression and altered glycosylation pathways. This review provides examples of emerging antibody-based products (mucosal and systemic) that could be competitive and commercially viable when the attributes of Nicotiana-based manufacturing (large scale, versatile, rapid, low cost) are utilized.
authors.affiliation: Mapp Biopharmaceutical, Inc., San Diego, CA, USA. kevin.whaley@mappbio.com
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Whaley
authors.forename: Andrew
authors.initials: A
authors.lastname: Hiatt
authors.forename: Larry
authors.initials: L
authors.lastname: Zeitlin
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology; D016229:Amyloid beta-Peptides / Q000276:immunology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000188:drug therapy; D001688:Biological Products / Q000096:biosynthesis; D001694:Biological Warfare / Q000517:prevention & control; D003132:Commerce; D021821:Communicable Diseases, Emerging / Q000276:immunology / Q000517:prevention & control; D003267:Contraception / Q000379:methods; D006031:Glycosylation; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D011134:Polysaccharides / Q000096:biosynthesis; D049168:Pregnancy, Unplanned; D018357:Respiratory Syncytial Virus Infections / Q000191:economics / Q000517:prevention & control; D012136:Respiratory Syncytial Viruses / Q000276:immunology; D012749:Sexually Transmitted Diseases / Q000517:prevention & control; D014026:Nicotiana / Q000276:immunology / Q000378:metabolism*; D022223:Vaccines, Subunit / Q000096:biosynthesis
chemical_list: D016229:Amyloid beta-Peptides; D000911:Antibodies, Monoclonal; D001688:Biological Products; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D011134:Polysaccharides; D022223:Vaccines, Subunit