title: Tuberculosis and tubulointerstitial nephritis: an intriguing puzzle.
abstract: Classical renal tuberculosis is a well-known cause of urinary tract scarring and calcification, and sometimes renal dysfunction. In the past two decades there have been reports, particularly from the United Kingdom among immigrants from the Indian subcontinent, of a more insidiously progressive form of renal disease. Ultrasound shows small smooth kidneys, and histology reveals tubulointerstitial nephritis including granulomas but not acid-fast bacilli. Evidence is mounting that the underlying cause may be tuberculosis, but the mechanism remains obscure.
authors.affiliation: Department of Renal Medicine and Transplantation, St George's Hospital, London, UK. Electronic address: jbeastwood@btinternet.com.
authors.forename: John B
authors.initials: JB
authors.lastname: Eastwood
authors.affiliation: Department of Cellular Pathology, St George's Hospital, London, UK.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Corbishley
authors.affiliation: Advanced Therapies Centre, London Clinic Cancer Centre, London, UK.
authors.forename: John M
authors.initials: JM
authors.lastname: Grange
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D001706:Biopsy; D002908:Chronic Disease; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000382:microbiology* / Q000503:physiopathology; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000208:ethnology / Q000382:microbiology* / Q000503:physiopathology / Q000628:therapy; D011237:Predictive Value of Tests; D017582:Renal Replacement Therapy; D013997:Time Factors; D016896:Treatment Outcome; D014398:Tuberculosis, Renal / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology / Q000382:microbiology* / Q000503:physiopathology
chemical_list: D000305:Adrenal Cortex Hormones; D000995:Antitubercular Agents