title: Emerging inflammasome effector mechanisms.
abstract: Caspase 1 activation by inflammasome complexes in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) induces the maturation and secretion of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. Recent reports have begun to identify additional inflammasome effector mechanisms that proceed independently of IL-1β and IL-18. These include the induction of pyroptotic cell death, the restriction of bacterial replication, the activation of lipid metabolic pathways for cell repair and the secretion of DAMPs and leaderless cytokines. These non-canonical functions of caspase 1 illustrate the diverse mechanisms by which inflammasomes might contribute to innate immunity, repair responses and host defence.
authors.affiliation: Department of Biochemistry, Ghent University, Ghent, Belgium. Mohamed.Lamkanfi@VIB-UGent.be
authors.forename: Mohamed
authors.initials: M
authors.lastname: Lamkanfi
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology / Q000378:metabolism; D020170:Caspase 1 / Q000502:physiology*; D053179:Caspase 7 / Q000378:metabolism; D016923:Cell Death; D002463:Cell Membrane Permeability; D003141:Communicable Diseases / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis / Q000378:metabolism; D004789:Enzyme Activation; D006019:Glycolysis; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D058847:Inflammasomes / Q000502:physiology*; D007249:Inflammation / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D051379:Mice; D018448:Models, Immunological; D053472:Nod Signaling Adaptor Proteins / Q000276:immunology; D009687:Nuclear Proteins / Q000276:immunology; D014947:Wounds and Injuries / Q000276:immunology
chemical_list: D016207:Cytokines; C101635:HIN-200 protein, human; D058847:Inflammasomes; D053472:Nod Signaling Adaptor Proteins; D009687:Nuclear Proteins; D053179:Caspase 7; D020170:Caspase 1