title: Bcl-2-regulated cell death signalling in the prevention of autoimmunity.
abstract: Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or correlate with autoimmunity in mice and men. This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention.
authors.affiliation: Division of Developmental Immunology, BIOCENTER, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Tischner
authors.forename: C
authors.initials: C
authors.lastname: Woess
authors.forename: E
authors.initials: E
authors.lastname: Ottina
authors.forename: A
authors.initials: A
authors.lastname: Villunger
mesh_terms: D000818:Animals; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000517:prevention & control*; D001402:B-Lymphocytes / Q000276:immunology / Q000502:physiology; D006801:Humans; D051379:Mice; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000502:physiology
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2