title: Wall stress reduction in abdominal aortic aneurysms as a result of polymeric endoaortic paving.
abstract: Polymeric endoaortic paving (PEAP) may improve endovascular repair of abdominal aortic aneurysms (AAA) since it has the potential to treat patients with complex AAA geometries while reducing the incidence of migration and endoleak. Polycaprolactone (PCL)/polyurethane (PU) blends are proposed as PEAP materials due to their range of mechanical properties, thermoformability, and resistance to biodegradation. In this study, the reduction in AAA wall stress that can be achieved using PEAP was estimated and compared to that resulting from stent-grafts. This was accomplished by mechanically modeling the anisotropic response of PCL/PU blends and implementing these results into finite element model (FEM) simulations. We found that at the maximum diameter of the AAA, the 50/50 and 10/90 PCL/PU blends reduced wall stress by 99 and 98%, respectively, while a stent-graft reduced wall stress by 99%. Our results also show that wall stress reduction increases with increasing PEAP thickness and PCL content in the blend ratio. These results indicate that PEAP can reduce AAA wall stress as effectively as a stent-graft. As such, we propose that PEAP may provide an improved treatment alternative for AAA, since many of the limitations of stent-grafts have the potential to be solved using this approach.
authors.affiliation: Biomedical Engineering Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA.
authors.forename: John H
authors.initials: JH
authors.lastname: Ashton
authors.forename: Avinash
authors.initials: A
authors.lastname: Ayyalasomayajula
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Simon
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Vande Geest
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008955:Models, Cardiovascular; D011091:Polyesters; D011140:Polyurethanes; D015607:Stents; D013312:Stress, Physiological
chemical_list: D011091:Polyesters; D011140:Polyurethanes; C016240:polycaprolactone