title: Comparison of bone scintigraphy and 18F-FDG PET-CT in a prostate cancer patient with osteolytic bone metastases.
abstract: A 62 year-old male with prostate cancer, recently complaining lumbar pain with elevated PSA level (6.83 ng/ml) was referred for evaluating bone metastases. Bone scintigraphy with (99m)Tc-MDP demonstrated intense uptake on third lumbar vertebra. Postoperative biopsy of the lesion on third lumbar vertebra revealed adenocarcinoma metastasis. For evaluating distant metastases and restaging, (18)F-FDG PET-CT was performed postoperatively. On PET-CT imaging there were cervical and left parailiac lymph nodes with FDG uptake, destruction on third lumbar vertebra level and intense soft tissue mass FDG uptake on the same area. Additionally, FDG uptake was detected on right iliac crest. On the CT images obtained by integrated PET-CT scanner, this uptake was matching with lytic bone metastases. The superiority of (18)F-FDG PET-CT for demonstrating osteolytic bone metastases compared to bone scintigraphy was presented in a case of prostate cancer in a patient with bone and lymph node metastases.
authors.affiliation: Department of Nuclear Medicine, Selcuklu Medical Faculty, Selcuk University, Selcuklu, Konya, Turkey. ppelinozcan@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Ozcan Kara
authors.forename: T
authors.initials: T
authors.lastname: Kara
authors.forename: G
authors.initials: G
authors.lastname: Kara Gedik
authors.forename: O
authors.initials: O
authors.lastname: Sari
authors.forename: O
authors.initials: O
authors.lastname: Sahin
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary*; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D005188:False Negative Reactions; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D010014:Osteolysis / Q000000981:diagnostic imaging* / Q000209:etiology; D049268:Positron-Emission Tomography; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology*; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18