title: Analgesic effect of intrathecally γ-aminobutyric acid transporter-1 inhibitor NO-711 administrating on neuropathic pain in rats.
abstract: To investigate the analgesic effect of intrathecally administered γ-aminobutyric acid (GABA) transporter-1 inhibitor NO-711 on the sciatic nerve chronic constriction injury (CCI) rats. 5 days after intrathecal catheter placement, neuropathic pain model was established by CCI of sciatic nerve on rats. Withdrawal thresholds for mechanical allodynia and latency for thermal hyperalgesia were measured in all animals. All rats operated upon for CCI displayed decreased withdrawal thresholds for mechanical allodynia and latency for thermal hyperalgesia, which has significant difference compared with sham groups. After intrathecal NO-711 administration, withdrawal thresholds and latency were significantly increased on CCI rats compared with control group after 1 day. The results show that GABA transporter-1 inhibitor could effectively develop analgesic effect in sciatic nerve CCI rats' model.
authors.affiliation: Department of Anaesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, PR China. liyicong2000@yahoo.com.cn
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.forename: Yicong
authors.initials: Y
authors.lastname: Li
authors.forename: Peifei
authors.initials: P
authors.lastname: Gu
authors.forename: Baojun
authors.initials: B
authors.lastname: Fu
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Enyou
authors.initials: E
authors.lastname: Li
mesh_terms: D000818:Animals; D018756:GABA Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D006358:Hot Temperature; D006930:Hyperalgesia / Q000188:drug therapy*; D007278:Injections, Spinal; D008297:Male; D009437:Neuralgia / Q000188:drug therapy*; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D009557:Nipecotic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D010091:Oximes / Q000494:pharmacology / Q000627:therapeutic use*; D010147:Pain Measurement / Q000187:drug effects*; D017288:Pain Threshold / Q000187:drug effects*; D010812:Physical Stimulation; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries; D020426:Sciatic Neuropathy / Q000188:drug therapy
chemical_list: D018756:GABA Antagonists; D014179:Neurotransmitter Uptake Inhibitors; D009557:Nipecotic Acids; D010091:Oximes; C078793:NNC 711