title: A new solvatochromic fluorophore for exploring nonpolar environments created by biopolymers.
abstract: The fluorescence of a new aminocyanonaphthalene exhibits exquisite sensitivity to its environment and responds to a solvent change from water to hexane with greater than a 100-fold increase in intensity and 100 nm shift in λ(max.em). These properties should support many applications including the detection of abasic sites within duplex DNA as illustrated below.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
authors.forename: Abulfazl
authors.initials: A
authors.lastname: Fakhari M
authors.forename: Steven E
authors.initials: SE
authors.lastname: Rokita
mesh_terms: D001483:Base Sequence; D001704:Biopolymers / Q000737:chemistry*; D004247:DNA / Q000032:analysis; D006586:Hexanes / Q000737:chemistry; D009281:Naphthalenes / Q000737:chemistry; D011789:Quantum Theory; D012997:Solvents / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods; D014867:Water / Q000737:chemistry
chemical_list: D001704:Biopolymers; D006586:Hexanes; D009281:Naphthalenes; D012997:Solvents; D014867:Water; C031721:naphthalene; D004247:DNA