title: Safety, efficacy, and utility of platelet-rich fibrin matrix in facial plastic surgery.
abstract: OBJECTIVE
  To evaluate the clinical safety and efficacy of the use of autologous platelet-rich fibrin matrix (PRFM) in facial plastic surgery.
  
  
  METHODS
  Medical charts of the last 50 patients with at least 3 months of follow-up who were treated by the author with PRFM for aesthetic purposes were reviewed for patient satisfaction, objective clinical results, and adverse events.
  
  
  RESULTS
  The study cohort of patients was followed up for a mean (SD) of 9.9 (8.0) months (range, 3-30 months). Most patients were treated for deep nasolabial folds, while the volume-depleted midface region, superficial rhytids, and acne scars were other commonly treated areas. The patients underwent an average of 1.6 treatments (range, 1-5 treatments). No patients reported any swelling lasting longer than 5 days, and most noted only minimal bruising lasting for 1 to 3 days. Most patients were satisfied with the results of their treatments, although 1 patient felt that there was limited or no improvement after 2 treatments.
  
  
  CONCLUSIONS
  Autologous PRFM treatment is a well-tolerated, excellent choice for use in the face. Further studies on the precise mechanism of action of PRFM are ongoing.
authors.affiliation: Division of Facial Plastic and Reconstructive Surgery, The New York Eye and Ear Infirmary, 310 E 14th Street, New York, NY 10003, USA. asclafani@nyee.edu
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Sclafani
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets; D015331:Cohort Studies; D003357:Cosmetic Techniques; D005145:Face / Q000601:surgery*; D005260:Female; D005337:Fibrin; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012189:Retrospective Studies; D014945:Wound Healing
chemical_list: D005337:Fibrin