title: The impact of environmental exposure to perfluorinated compounds on oocyte fertilization capacity.
abstract: In an attempt to assess the effect of perfluorinated compounds (PFC) on oocytes quality and fertilization rate, we studied follicular fluid (FF) PFC levels in 18 patients undergoing IVF-ET cycles. A significant correlation (R = 0.75; P < 0.001) was observed between FF PFC levels and fertilization rate. Moreover, patients with FF PFC contamination had significantly lower fertilization rate (p < 0.02) and number of embryos transferred (p < 0.02), compared to the PFC negative group.
authors.affiliation: Department Biomedical Sciences, Applied Biology Section, University of Siena, Siena, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Governini
authors.forename: Raoul
authors.initials: R
authors.lastname: Orvieto
authors.forename: Cristiana
authors.initials: C
authors.lastname: Guerranti
authors.forename: Laura
authors.initials: L
authors.lastname: Gambera
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Leo
authors.forename: Paola
authors.initials: P
authors.lastname: Piomboni
mesh_terms: D000328:Adult; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D005260:Female; D005307:Fertilization in Vitro; D005466:Fluorocarbons / Q000032:analysis / Q000633:toxicity*; D015571:Follicular Fluid / Q000737:chemistry*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D009865:Oocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D010865:Pilot Projects
chemical_list: D004785:Environmental Pollutants; D005466:Fluorocarbons