title: The interleukin-6 promoter (-597/-572/-174)genotype does not affect interleukin-6 production in hemodialysis patients.
abstract: Kidney transplant recipients with the interleukin-6 (IL-6) GGG/GGG promoter (-597/-572/-174)genotype were shown to have a better long-term outcome. Further, the same (-597/-572/-174)genotype was found to be associated with less IL-6 production in healthy control subjects. To verify this observation in potential kidney transplant recipients, IL-6 production was analyzed in 85/142 hemodialysis patients. We could not confirm an impaired IL-6 secretion in carriers of the GGG/GGG (-597/-572/-174)genotype and propose a significantly lower IL-6 production in hemodialysis patients versus healthy control subjects to explain this. However, we suggest subsequent studies of IL-6 production in kidney allograft recipients to further elucidate the pathophysiological relevance of IL-6 for transplant outcome.
authors.affiliation: Institute of Transfusion Medicine and Immunology, Heidelberg University, Mannheim, Germany.
authors.forename: Friederike
authors.initials: F
authors.lastname: Schulte
authors.forename: Peter
authors.initials: P
authors.lastname: Schnülle
authors.forename: Peter
authors.initials: P
authors.lastname: Bugert
authors.forename: Harald
authors.initials: H
authors.lastname: Klüter
authors.forename: Michael
authors.initials: M
authors.lastname: Müller-Steinhardt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004252:DNA Mutational Analysis; D005838:Genotype; D006085:Graft Survival / Q000235:genetics; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism*; D016030:Kidney Transplantation; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D015850:Interleukin-6