title: Biological activity of volatiles from marine and terrestrial bacteria.
abstract: The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter strains. While some of the compounds specific to certain bacteria showed some activity in the antiproliferative assay, the compounds common to many bacteria were mostly inactive. In contrast, some of these compounds were active in the quorum-sensing-tests. γ-Lactones showed a broad reactivity, while pyrazines seem to have only low intrinsic activity. A general discussion on the ecological importance of these findings is given.
authors.affiliation: Institute of Organic Chemistry, University of Braunschweig-Institute of Technology, Hagenring 30, Braunschweig, Germany. Stefan.Schulz@tu-bs.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Schulz
authors.forename: Jeroen S
authors.initials: JS
authors.lastname: Dickschat
authors.forename: Brigitte
authors.initials: B
authors.lastname: Kunze
authors.forename: Irene
authors.initials: I
authors.lastname: Wagner-Dobler
authors.forename: Randi
authors.initials: R
authors.lastname: Diestel
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
mesh_terms: D000818:Animals; D001419:Bacteria / Q000737:chemistry* / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects*; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D009792:Oceans and Seas; D053038:Quorum Sensing / Q000187:drug effects*; D012623:Seawater / Q000382:microbiology*; D015398:Signal Transduction / Q000187:drug effects; D055549:Volatile Organic Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007783:Lactones; D055549:Volatile Organic Compounds