title: [Wegener's granulomatosis with subglottic stenosis: options for local and systemic treatment. Review of the literature].
abstract: BACKGROUND
  Wegener's granulomatosis (WG) is a primary systemic vasculitis with characteristic clinical manifestations from upper airways, lungs, and kidneys. Subglottic stenosis is one of the local symptoms which may occur independently or in association with involvement of other organs.
  
  
  METHODS
  We present a patient with systemic WG positive for C-ANCA. Regression of pulmonary changes was achieved with induction therapy but the patient developed subglottic stenosis. Endotracheal dilation was partly successful, so systemic treatment had to be reintroduced to inhibit the activity of the disease.
  
  
  CONCLUSIONS
  The problem of localized organ lesions in the course of a systemic disease is discussed. It is important to distinguish between signs of active disease requiring systemic therapy and organ lesions which demand a localized approach.
authors.affiliation: Katedra i Klinika Reumatologii i Układowych Chorób Tkanki Łacznej Uniwersytetu Medycznego w Lublinie ul. Jaczewskiego 8, 20-950 Lublin.
authors.forename: Bozena
authors.initials: B
authors.lastname: Targońska-Stepniak
authors.forename: Maria
authors.initials: M
authors.lastname: Majdan
mesh_terms: D000293:Adolescent; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D007829:Laryngostenosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003520:Cyclophosphamide; D011433:Propranolol; D008775:Methylprednisolone