title: Asymmetric aza-Mannich addition: synthesis of modified chiral 2-(ethylthio)-thiazolone derivatives with anticancer potency.
abstract: An easily prepared cinchona alkaloid derivative was found to be an effective organocatalyst in a direct, enantioselective aza-Mannich addition. By establishing a quaternary carbon stereocenter, a series of modified chiral 2-(ethylthio)-thiazolone derivatives have been obtained with excellent diastereo- and enantioselectivities. And these derivatives have been found to show anticancer activities against five different cancer cell lines using the MTT assay.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Liu
authors.forename: Leijiao
authors.initials: L
authors.lastname: Deng
authors.forename: Hongjin
authors.initials: H
authors.lastname: Song
authors.forename: Huazhen
authors.initials: H
authors.lastname: Jia
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002244:Carbon; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000596:Amino Acids; D000972:Antineoplastic Agents, Phytogenic; D002930:Cinchona Alkaloids; D013844:Thiazoles; D002244:Carbon