title: Serum adenosine deaminase activity in patients with systemic lupus erythematosus: a study based on ADA1 and ADA2 isoenzymes pattern.
abstract: Adenosine deaminase (ADA) plays a crucial role in the development and maintenance of normal immune system. So, any immunological imbalances could associate with its altered activity in serum. This study evaluated the activity of total ADA and its isoenzymes in serum of 45 patients with systemic lupus erythematosus (SLE). Included were 23 patients with active SLE, 22 during the inactive phase of the disease, and 45 healthy subjects. Our results provided evidence that the significantly elevated total ADA activity in serum of SLE patients is correlated mainly with the increased ADA2 level. The highest mean ADA2 activity during the relapse phase of the disease could be an indication to the macrophages, the main source of ADA2. It might be concluded that ADA and its isoenzymes analysis in serum of patients could be used as a useful and non-invasive diagnostic tool in evaluation of SLE active phase and the disease severity.
authors.affiliation: Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Saghiri
authors.forename: Niloufar
authors.initials: N
authors.lastname: Ghashghai
authors.forename: Shafieh
authors.initials: S
authors.lastname: Movaseghi
authors.forename: Pegah
authors.initials: P
authors.lastname: Poursharifi
authors.forename: Shohreh
authors.initials: S
authors.lastname: Jalilfar
authors.forename: Manijeh Ahmadi
authors.initials: MA
authors.lastname: Bidhendi
authors.forename: Leila
authors.initials: L
authors.lastname: Ghazizadeh
authors.forename: Mina
authors.initials: M
authors.lastname: Ebrahimi-Rad
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007492:Iran; D007527:Isoenzymes; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis / Q000201:enzymology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; C548482:ADA protein, human; D000243:Adenosine Deaminase