title: Angle-supported phakic intraocular lens for correction of moderate to high myopia: Three-year interim results in international multicenter studies.
abstract: OBJECTIVE
  To evaluate the safety and effectiveness of an angle-supported phakic intraocular lens (pIOL) for correction of moderate to high myopia.
  
  
  METHODS
  Ophthalmology centers in the United States, Canada, and the European Union.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  This study comprised patients with moderate to high myopia (range -6.00 to -16.50 diopters [D]) who had implantation of the AcrySof Cachet pIOL. Outcome measures included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), predictability, stability of the manifest refraction spherical equivalent (MRSE), adverse events, and endothelial cell density (ECD).
  
  
  RESULTS
  Pooled interim data from 360 patients assessed for up to 3 years postoperatively are presented. Of the 104 patients who reached the 3-year visit, the UDVA was 20/40 or better in 101 (97.1%) and 20/20 or better in 48 (46.2%). The CDVA was 20/32 or better in 103 (99.0%) of the 104 patients and 20/20 or better in 84 patients (80.8%). The mean MRSE was -0.24 D ± 0.55 (SD) (range -2.00 to 1.63 D). The residual refractive error was within ±0.50 D of target in 82 patients (78.8%) and within ±1.00 D in 95 patients (91.3%). The annualized percentage loss in central ECD and peripheral ECD from 6 months to 3 years was 0.41% and 1.11%, respectively. No pupil ovalization, pupillary block, or retinal detachment was observed.
  
  
  CONCLUSIONS
  Three-year findings from pooled global studies showed that the angle-supported pIOL provided favorable refractive correction and predictability and acceptable safety in patients with moderate to high myopia.
authors.affiliation: FreeVis LASIK Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. knorz@eyes.de
authors.forename: Michael C
authors.initials: MC
authors.lastname: Knorz
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Lane
authors.forename: Simon P
authors.initials: SP
authors.lastname: Holland
mesh_terms: D000293:Adolescent; D000328:Adult; D002452:Cell Count; D015331:Cohort Studies; D004728:Endothelium, Corneal / Q000473:pathology; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D017060:Patient Satisfaction; D054120:Phakic Intraocular Lenses; D011183:Postoperative Complications; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult