title: Synthesis and characterization of heteroleptic copper and zinc complexes with saccharinate and aminoacids. Evaluation of SOD-like activity of the copper complexes.
abstract: Five new copper and zinc heteroleptic complexes with saccharin and aminoacids with general stoichiometry Na(2)[M(sac)(2)(aa)(2)].nH(2)O (M denotes Cu or Zn, sac the saccharinate ion, and aa the aminoacids) were synthesized and characterized by elemental and thermogravimetric analysis, conductimetric measurements and IR, Raman and UV-vis spectroscopies. In all the complexes, copper and zinc ions coordinated with the aminoacids through the terminal amine and carboxylate residues and with saccharin through the heterocyclic nitrogen atom. Besides, the superoxide dismutase-like activity of the heteroleptic copper complexes was evaluated and compared with the homoleptic copper amino acid complexes with the aim to observe the influence of the saccharin coordination.
authors.affiliation: Química Inorgánica (DEC), Facultad de Química (UDELAR), Gral. Flores 2124, Montevideo, Uruguay.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Santi
authors.forename: Inés
authors.initials: I
authors.lastname: Viera
authors.forename: Alvaro
authors.initials: A
authors.lastname: Mombrú
authors.forename: Jorge
authors.initials: J
authors.lastname: Castiglioni
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Baran
authors.forename: María H
authors.initials: MH
authors.lastname: Torre
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman; D013482:Superoxide Dismutase / Q000737:chemistry; D013818:Thermogravimetry; D015032:Zinc / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D003300:Copper; D013482:Superoxide Dismutase; D015032:Zinc