title: Silica sulfuric acid as mild and efficient catalyst for the preparation of poly-hydroxyl aromatic compounds under mild and heterogeneous conditions.
abstract: A simple, clean and highly efficient method for the preparation of polyhydroxyl aromatic compounds is described from the reaction of 2,6-bis(methylol)phenols and different substituted phenols in the presence of silica sulfuric acid (SSA) as a heterogeneous catalyst. SSA afforded the clean synthesis of target compounds in much higher yields than traditional catalysts. The established method is also suitable for the synthesis of phloroglucinol derivatives (Phloroglucides) and other polyhydric phenols. Besides the easy work-up of the reaction mixture, the comfortable purification of the products is another advantage of this method.
authors.affiliation: Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454, Iran. khalafi@chem.susc.ac.ir
authors.forename: Ali
authors.initials: A
authors.lastname: Khalafi-Nezhad
authors.forename: Abolfath
authors.initials: A
authors.lastname: Parhami
authors.forename: Rahele
authors.initials: R
authors.lastname: Bargebid
authors.forename: Saghar
authors.initials: S
authors.lastname: Molazade
authors.forename: Abdolkarim
authors.initials: A
authors.lastname: Zare
authors.forename: Habib
authors.initials: H
authors.lastname: Foroughi
mesh_terms: D002384:Catalysis / Q000187:drug effects; D055808:Drug Discovery; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006878:Hydroxides / Q000737:chemistry* / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D010636:Phenols / Q000138:chemical synthesis / Q000378:metabolism; D017640:Silicates / Q000378:metabolism*; D012997:Solvents / Q000494:pharmacology; D013464:Sulfuric Acids / Q000737:chemistry*
chemical_list: D006841:Hydrocarbons, Aromatic; D006878:Hydroxides; D004364:Pharmaceutical Preparations; D010636:Phenols; D017640:Silicates; D012997:Solvents; D013464:Sulfuric Acids; C033158:sulfuric acid