title: Evaluation of BIC and cross validation for model selection on sequence segmentations.
abstract: Segmentation is a general data mining technique for summarising and analysing sequential data. Segmentation can be applied, e.g., when studying large-scale genomic structures such as isochores. Choosing the number of segments remains a challenging question. We present extensive experimental studies on model selection techniques, Bayesian Information Criterion (BIC) and Cross Validation (CV). We successfully identify segments with different means or variances, and demonstrate the effect of linear trends and outliers, frequently occurring in real data. Results are given for real DNA sequences with respect to changes in their codon, G + C, and bigram frequencies, and copy-number variation from CGH data.
authors.affiliation: HIIT, University of Helsinki and Helsinki University of Technology, P.O. Box 68, FI-00014 University of Helsinki, Finland. niina.haiminen@cs.helsinki.fi
authors.forename: Niina
authors.initials: N
authors.lastname: Haiminen
authors.forename: Heikki
authors.initials: H
authors.lastname: Mannila
mesh_terms: D001483:Base Sequence; D003062:Codon / Q000235:genetics; D055028:Comparative Genomic Hybridization / Q000379:methods; D004247:DNA / Q000737:chemistry; D057225:Data Mining / Q000379:methods*; D016678:Genome; D023281:Genomics / Q000379:methods*
chemical_list: D003062:Codon; D004247:DNA