title: Synthesis of N-glycopeptides applying glycoamino Acid building blocks with a combined fmoc/boc strategy.
abstract: Mono-, di- and trisaccharide representing the reducing terminal of the core structure of N-glycans were incorporated into Leu-Lys-Asn-Gly-Gly-Pro hexapeptide that is a partial structure of the Trp-cage mini-protein by linear assembly. These studies provide evidence that the used combination of Fmoc and Boc strategy and mild conditions result in glycopeptides in high purity and reasonable yield.
authors.affiliation: Department of Medical Chemistry, Faculty of General Medicine, University of Szeged, 6720 Szeged Dóm tér 8., Hungary. tgabor@mdche.szote.u-szeged.hu.
authors.forename: Kinga
authors.initials: K
authors.lastname: Rákosi
authors.forename: Orsolya
authors.initials: O
authors.lastname: Szolomájer-Csikós
authors.forename: László
authors.initials: L
authors.lastname: Kalmár
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szurmai
authors.forename: János
authors.initials: J
authors.lastname: Kerékgyártó
authors.forename: Gábor K
authors.initials: GK
authors.lastname: Tóth
mesh_terms: D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D006020:Glycopeptides