title: The brazilian version of the Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA): Four-stage translation and validation.
abstract: OBJECTIVE
  This study reports on the Brazilian Portuguese adaptation of the QoL-AGHDA (Quality of Life Assessment of Growth Hormone Deficiency in Adults) for use in adult growth hormone deficient (GHD) patients.
  
  
  METHODS
  The translation process adopted the dual panel methodology. The questionnaire was tested through field-test interviews (16 GHD patients). In the final stage, data from 120 GHD patients (81 included in a test-retest analysis) were analyzed for internal consistency, test-retest reliability, convergent validity and validity among known groups.
  
  
  RESULTS
  The translation panels were successful and the draft version was amended to improve the wording as a result of the field-test interviews. Cronbach's alpha was 0.90 and test-retest reliability 0.88. QoL-AGHDA scores had the expected pattern of association with NHP scale scores and QoL-AGHDA was able to differentiate significantly between patients based on patient-reported general health (p < 0.01) and QoL (p < 0.01).
  
  
  CONCLUSIONS
  The adaptation of the QoL-AGHDA for a Brazilian population was successful and the adapted questionnaire was shown to be reliable and valid.
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. brolivei@uol.com.br
authors.forename: Antônio
authors.initials: A
authors.lastname: Ribeiro-Oliveira
authors.forename: Suélem Simão
authors.initials: SS
authors.lastname: Mol
authors.forename: James
authors.initials: J
authors.lastname: Twiss
authors.forename: Guilherme Asmar
authors.initials: GA
authors.lastname: Alencar
authors.forename: Paulo Augusto Carvalho
authors.initials: PA
authors.lastname: Miranda
authors.forename: Luciana A
authors.initials: LA
authors.lastname: Naves
authors.forename: Monalisa F
authors.initials: MF
authors.lastname: Azevedo
authors.forename: Flávia M A
authors.initials: FM
authors.lastname: Basílio
authors.forename: César Luiz
authors.initials: CL
authors.lastname: Boguszewski
authors.forename: Kátia C
authors.initials: KC
authors.lastname: Nogueira
authors.forename: Lúcio
authors.initials: L
authors.lastname: Vilar
authors.forename: Maria
authors.initials: M
authors.lastname: Koltowska-Haggstrom
authors.forename: Steve P
authors.initials: SP
authors.lastname: McKenna
mesh_terms: D000328:Adult; D001938:Brazil; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires / Q000592:standards*; D014177:Translations
chemical_list: D019382:Human Growth Hormone