title: The construction of quaternary stereocenters by the Henry reaction: circumventing the usual reactivity of substituted glyoxals.
abstract: The enantioselective Henry reaction between alkyl- and arylglyoxal hydrates and nitromethane catalyzed by Cu(II)-iminopyridine complexes takes place regioselectively on the ketone carbonyl group to give chiral tertiary nitroaldols with high functional group density and enantiomeric excesses of up to 96 %. Both aromatic and aliphatic glyoxals are suitable substrates for this reaction.
authors.affiliation: Departament de Química Orgànica, Facultat de Química, Universitat de València, C/Dr. Moliner 50, Burjassot (València), Spain. gonzalo.blay@uv.es
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Blay
authors.forename: Víctor
authors.initials: V
authors.lastname: Hernández-Olmos
authors.forename: José R
authors.initials: JR
authors.lastname: Pedro