title: Correlation of Ochratoxin A exposure to urinary levels of 8-hydroxydeoxyguanosine and malondialdehyde in a Turkish population.
abstract: Ochratoxin A is one of the most abundant food- contaminating mycotoxins in the world that is immunosuppressive, genotoxic, teratogenic and carcinogenic. Malondialdehyde is a naturally occurring product of lipid peroxidation that is mutagenic and carcinogenic. 8-Hydroxydeoxyguanosine is produced during the interaction of reactive oxygen species and DNA. In this study, Ochratoxin A, malondialdehyde and 8-Hydroxydeoxyguanosine levels of individuals in the study group were measured and results were correlated with each other. Additionally, the correlation of biomarker levels to smoking habit, alcohol and coffee consumption, age and gender of individuals was investigated. As a result of these assessments, a significant correlation was observed between Ochratoxin A exposures and malondialdehyde and 8-Hydroxydeoxyguanosine levels.
authors.affiliation: Faculty of Pharmacy, Department of Toxicology, Ankara University, 06100 Tandogan, Ankara, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Ates
authors.forename: Ozge Cemiloglu
authors.initials: OC
authors.lastname: Ulker
authors.forename: Cigdem
authors.initials: C
authors.lastname: Akdemir
authors.forename: Asuman
authors.initials: A
authors.lastname: Karakaya
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000652:urine*; D009793:Ochratoxins / Q000652:urine*; D014421:Turkey
chemical_list: D015415:Biomarkers; D009793:Ochratoxins; C025589:ochratoxin A; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003404:Creatinine; D003849:Deoxyguanosine