title: Sequence variations in human ZP genes as potential modifiers of zona pellucida architecture.
abstract: To examine putative associations between zona pellucida (ZP) anomalies and sequence variations in genes expressing structural ZP glycoprotein components, sequence data of 31 volunteers participating in IVF treatments were obtained and analyzed together with morphologic data of the respective oocytes. Our results suggest that some of the most frequent zona anomalies may be at least partly explained by sequence variations in genes expressing the four human ZP proteins, especially those in ZP2 and ZP3.
authors.affiliation: Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland.
authors.forename: Reeta-Maria
authors.initials: RM
authors.lastname: Pökkylä
authors.forename: Jouni Tapani
authors.initials: JT
authors.lastname: Lakkakorpi
authors.forename: Sinikka Helena
authors.initials: SH
authors.lastname: Nuojua-Huttunen
authors.forename: Juha Samuli
authors.initials: JS
authors.lastname: Tapanainen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004527:Egg Proteins / Q000235:genetics*; D005260:Female; D005298:Fertility / Q000235:genetics*; D005307:Fertilization in Vitro; D005387:Finland; D014644:Genetic Variation; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*; D020554:Sperm Injections, Intracytoplasmic; D015044:Zona Pellucida / Q000473:pathology*; D000072216:Zona Pellucida Glycoproteins
chemical_list: D004527:Egg Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C000606515:ZP2 protein, human; C000606517:ZP3 protein, human; D000072216:Zona Pellucida Glycoproteins