title: [Treatment of interstitial cystitis by intravesical instillation of hyaluronic acid: A prospective study on 31 patients].
abstract: OBJECTIVE
  We evaluate the efficacy of hyaluronate acid instillation for treatment of interstitial cystitis (IC).
  
  
  METHODS
  From March 2008 to May 2009, a prospective study included 31 patients. We used the new definition of IC established by the ICS in 2002. Patients have a urinalysis, a cystoscopy, a hydrodistension test and bladder biopsies. The urodynamic evaluation was not systematic. Patients received weekly six instillations of 40mg (50ml) intravesical hyaluronate acid. We evaluated the efficacy and safety of treatment with two specific questionnaires of interstitial cystitis filled before and after 6 weeks of treatment: the O'Leary-Sant and Pelvic pain and Urgency/Frequency (PUF).
  
  
  RESULTS
  Four groups were defined: good response, partial response, poor response and no response. They were composed by 14 patients (45%), two (7%), seven (22%) and eight patients (26%). We obtained 52% positive response (good response and partial response) after 6 weeks of treatment. Patients with cystoscopy and histology abnormal had a response rate of 60%. No serious side effects were observed.
  
  
  CONCLUSIONS
  Hyaluronate acid has a place in the treatment of interstitial cystitis with an efficiency comparable to other treatments and good tolerance. The response rate to treatment can be improved by better selection of patients, particularly those having a cystoscopy and histology abnormal.
authors.affiliation: Service d'urologie, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France. svanagt2001@yahoo.fr
authors.forename: S
authors.initials: S
authors.lastname: Van Agt
authors.forename: F
authors.initials: F
authors.lastname: Gobet
authors.forename: L
authors.initials: L
authors.lastname: Sibert
authors.forename: A-M
authors.initials: AM
authors.lastname: Leroi
authors.forename: P
authors.initials: P
authors.lastname: Grise
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018856:Cystitis, Interstitial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000276:Adjuvants, Immunologic; D006820:Hyaluronic Acid