title: [Possibility of an emission computer tomography for an estimation cerebral perfusion at patients with carotid stenoses before and after stenting].
abstract: OBJECTIVE
  To estimate possibilities for studies of cerebral perfusion with brain scintigraphy for revealing and an estimation of features of change brain perfusion at patients with a cardio-cerebral vascular pathology before and after carotid stenting (CAS).
  
  
  METHODS
  11 patients with established (after carotid angiography) stenosis of internal carotid artery and coronary artery disease have been studied with SPECT with analogue HMPAO teoxim--Tc99M after intravenous introduction 700 MBk up to and in 5 days and in the remote period after stenting. For analysis of results the program "Neurogam" have been used. Standartized perfusion maps have been created.
  
  
  RESULTS
  Before performing CAS various variants of the image cerebral perfusion maps have been obtained: from diffuse insignificant reduction in both hemispheres of a brain up to the regions hypoperfusion, characteristic for ischemic changes. Regions of hypoperfusion on the side opposite to a stenosis or occasion were revealed. SPECT, performed after cas on 5th day or after 2-3 months found increase of general brain perfusion, disappearance of symmetric both asymmetric regions hypoperfusion and reduction of a degree local hypoperfusion on the side of stenting.
  
  
  CONCLUSIONS
  Maps of brain perfusion before and after CAS adequately reflect microcirculation of a brain with local changes of perfusion. Use of perfusion parameters gives possibility to estimate changes of brain perfusion before and after CAS in patients with combined carotid and coronary pathology.
authors.forename: S V
authors.initials: SV
authors.lastname: Volkov
authors.forename: T N
authors.initials: TN
authors.lastname: Sharypova
authors.forename: A M
authors.initials: AM
authors.lastname: Smirnov
authors.forename: V E
authors.initials: VE
authors.lastname: Sinitsyn
authors.forename: K V
authors.initials: KV
authors.lastname: Liadov
mesh_terms: D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy*; D003327:Coronary Disease / Q000150:complications* / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010091:Oximes; D055420:Perfusion Imaging; D011877:Radionuclide Imaging / Q000379:methods*; D019275:Radiopharmaceuticals; D015607:Stents; D019690:Technetium Tc 99m Exametazime; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D010091:Oximes; D019275:Radiopharmaceuticals; C068296:hexamethylpropyleneamine oxime; D019690:Technetium Tc 99m Exametazime