title: Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy.
abstract: New anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2-side chain yielded analogs with improved efficacy in the rat lethal toxin model.
authors.affiliation: PanThera Biopharma, LLC, Aiea, HI 96701, USA.
authors.forename: Seongjin
authors.initials: S
authors.lastname: Kim
authors.forename: Guan-Sheng
authors.initials: GS
authors.lastname: Jiao
authors.forename: Mahtab
authors.initials: M
authors.lastname: Moayeri
authors.forename: Devorah
authors.initials: D
authors.lastname: Crown
authors.forename: Lynne
authors.initials: L
authors.lastname: Cregar-Hernandez
authors.forename: Linda
authors.initials: L
authors.lastname: McKasson
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Margosiak
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Leppla
authors.forename: Alan T
authors.initials: AT
authors.lastname: Johnson
mesh_terms: D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D000942:Antigens, Bacterial / Q000506:poisoning*; D001427:Bacterial Toxins / Q000506:poisoning*; D015394:Molecular Structure; D011041:Poisoning / Q000188:drug therapy; D051381:Rats
chemical_list: D000931:Antidotes; D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C030325:anthrax toxin