title: Long-term survival in a patient with node-positive adult-onset Xp11.2 translocation renal cell carcinoma.
abstract: Adult-onset Xp11.2 translocation renal cell carcinoma is a rare malignancy that has an aggressive clinical course and poor prognosis. The reasons for this include the fact that most patients have an advanced clinical stage at diagnosis and also that there is a lack of effective systemic therapy. We herein present the case of a 32-year-old woman suffering from node-positive Xp11.2 translocation renal cell carcinoma who underwent radical nephrectomy with an extensive retroperitoneal lymph node dissection, followed by two times of surgical resection for recurrent nodal disease. The patient has experienced no recurrent disease 4.5 years after the last operation and remains free of disease. Surgical approach to recurrent disease, if the recurrent site can be judged to be limited, might be one of the feasible treatment options in patients with Xp11.2 translocation renal cell carcinoma.
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Aoyagi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Shinohara
authors.forename: Kanako
authors.initials: K
authors.lastname: Kubota-Chikai
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nonomura
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000628:therapy; D002869:Chromosome Aberrations; D041321:Chromosomes, Human, X; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000494:pharmacology; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000628:therapy; D008198:Lymph Nodes / Q000473:pathology; D009392:Nephrectomy / Q000379:methods; D019275:Radiopharmaceuticals / Q000494:pharmacology; D012008:Recurrence; D014178:Translocation, Genetic; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18