title: [The role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and the inhibitors].
abstract: The late stages of the HIV-1 replication cycle are important to the overall replication cycle. During the late stages, HIV-1 replication undergoes the processes of assembly, release, and maturation, resulting in the production of a mature virus particle capable of infecting a new target cell. The structural protein Gag and its related gene (protein) play a central role in these pathways. The different regions of Gag worked in concert to drive production of a mature infectious particle through protein-protein, protein-RNA and protein-lipid interactions. The designed drug aimed directly at these stages can efficiently block the maturation and infectivity of HIV-1. In this article, the role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and related inhibitors is reviewed.
authors.affiliation: Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xin-yong
authors.initials: XY
authors.lastname: Liu
mesh_terms: D000666:Amphotericin B / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D044482:Benzeneacetamides / Q000737:chemistry / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000494:pharmacology; D015750:Genes, gag; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D010671:Phenylurea Compounds / Q000737:chemistry / Q000494:pharmacology; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology; D013386:Succinates / Q000737:chemistry / Q000494:pharmacology; D013457:Sulfur Compounds / Q000737:chemistry / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology; D019065:Virus Assembly / Q000187:drug effects; D057074:Virus Release / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects* / Q000502:physiology; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000378:metabolism / Q000502:physiology*; D053978:Pentacyclic Triterpenes
chemical_list: D000666:Amphotericin B; D019380:Anti-HIV Agents; D044482:Benzeneacetamides; D005663:Furans; D010671:Phenylurea Compounds; D010880:Piperidines; D013386:Succinates; D013457:Sulfur Compounds; D014315:Triterpenes; D054301:gag Gene Products, Human Immunodeficiency Virus; C524481:2-(1-(2-(2,3-dihydro-1-benzofuran-5-yl)ethyl)piperidin-3-yl)-2,2-diphenylacetamide; C473485:N-(3-chloro-4-methylphenyl)-N'-(2-(((5-((dimethylamino)-methyl)-2-furyl)-methyl)-sulfanyl)ethyl)urea; C017501:methylamphotericin B; C479935:bevirimat; D053978:Pentacyclic Triterpenes