title: Magnetic resonance VIBE venography using the blood pool contrast agent gadofosveset trisodium--an interrater reliability study.
abstract: OBJECTIVE
  In this study, image quality of leg veins and vena cava inferior was scored by independent raters using the new intravascular magnetic resonance imaging (MRI) contrast agent gadofosveset trisodium using fat-suppressed 3D gradient echo Volume Interpolated Breath-hold Examination.
  
  
  METHODS
  The leg venous system without clinical signs of deep venous thrombosis (DVT) and sonography-ruled out DVT were imaged using a fat-suppressed 3D gradient echo Volume Interpolated Breath-hold Examination (VIBE FS). Image interpretation was done independently by two experienced radiologists (raters) using a 5-point scoring system.
  
  
  RESULTS
  High diagnostic image quality with an overall mean visibility score of 4.8±0.1 was acquired in patients enrolled in the study using gadofosveset trisodium-enhanced MRI for the venous system of the leg. There were no cases with moderate, poor or nondiagnostic image quality. Additionally, an excellent interrater reliability was observed.
  
  
  CONCLUSIONS
  This study shows the feasibility of acquiring high resolution images with excellent image quality of the venous system of the leg using gadofosveset trisodium.
authors.affiliation: Department of Internal Medicine III, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07747 Jena, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Pfeil
authors.forename: Stefan
authors.initials: S
authors.lastname: Betge
authors.forename: Guenther
authors.initials: G
authors.lastname: Poehlmann
authors.forename: Joachim
authors.initials: J
authors.lastname: Boettcher
authors.forename: Robert
authors.initials: R
authors.lastname: Drescher
authors.forename: Ansgar
authors.initials: A
authors.lastname: Malich
authors.forename: Gunter
authors.initials: G
authors.lastname: Wolf
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Mentzel
authors.forename: Andreas
authors.initials: A
authors.lastname: Hansch
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D005682:Gadolinium; D006801:Humans; D021621:Imaging, Three-Dimensional; D007866:Leg / Q000098:blood supply*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D011655:Pulmonary Embolism / Q000175:diagnosis; D015203:Reproducibility of Results; D014682:Vena Cava, Inferior; D020246:Venous Thrombosis / Q000175:diagnosis
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D005682:Gadolinium; C109932:gadofosveset trisodium