title: Optical coherence tomography for the quantitative study of cerebrovascular physiology.
abstract: Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.
authors.affiliation: Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. vjsriniv@nmr.mgh.harvard.edu
authors.forename: Vivek J
authors.initials: VJ
authors.lastname: Srinivasan
authors.forename: Dmitriy N
authors.initials: DN
authors.lastname: Atochin
authors.forename: Harsha
authors.initials: H
authors.lastname: Radhakrishnan
authors.forename: James Y
authors.initials: JY
authors.lastname: Jiang
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ruvinskaya
authors.forename: Weicheng
authors.initials: W
authors.lastname: Wu
authors.forename: Scott
authors.initials: S
authors.lastname: Barry
authors.forename: Alex E
authors.initials: AE
authors.lastname: Cable
authors.forename: Cenk
authors.initials: C
authors.lastname: Ayata
authors.forename: Paul L
authors.initials: PL
authors.lastname: Huang
authors.forename: David A
authors.initials: DA
authors.lastname: Boas
mesh_terms: D000792:Angiography / Q000379:methods; D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D017078:Laser-Doppler Flowmetry / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D041623:Tomography, Optical Coherence / Q000379:methods*