title: Randomized controlled single center study comparing a polyhexanide containing bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal burns.
abstract: OBJECTIVE
  A prospective, randomized, controlled single center study was designed to evaluate clinical efficacy of a polyhexanide containing bio-cellulose dressing (group B) compared to a silver-sulfadiazine cream (group A) in sixty partial-thickness burn patients.
  
  
  METHODS
  Local ethics committee approval was obtained and patients consented. Parameters were: pain reduction (VAS), healing time and wound bed condition, comparing day 0 (start) versus day 14 (end), as well as, ease of dressing use and treatment costs.
  
  
  RESULTS
  All completed the study (n=30/n=30) and were included in the ITT analysis, with a total of 72 burns (group A: n=38, group B: n=34). We noted no differences in healing time. Pain reduction was significantly faster and better in group B (p<0.01). There were fewer dressing changes in group B, compared to group A. Ease of use for the bio-cellulose dressing was rated better compared to group A. In group B, € 95.20 was saved for a 10 day treatment period, compared to group A.
  
  
  CONCLUSIONS
  Group B demonstrated a better and faster pain reduction in the treated partial-thickness burns, compared to group A. The results indicate the polyhexanide containing bio-cellulose dressing to be a safe and cost effective treatment for partial-thickness burns.
authors.affiliation: Department of Plastic Surgery and Hand Surgery-Burn Unit, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52057 Aachen, Germany. apiatkowski@ukaachen.de
authors.forename: A
authors.initials: A
authors.lastname: Piatkowski
authors.forename: N
authors.initials: N
authors.lastname: Drummer
authors.forename: A
authors.initials: A
authors.lastname: Andriessen
authors.forename: D
authors.initials: D
authors.lastname: Ulrich
authors.forename: N
authors.initials: N
authors.lastname: Pallua
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001458:Bandages / Q000191:economics; D001645:Biguanides / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000191:economics / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy / Q000191:economics / Q000628:therapy*; D002482:Cellulose / Q000627:therapeutic use*; D005260:Female; D017048:Health Care Costs; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011446:Prospective Studies; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D001645:Biguanides; D001672:Biocompatible Materials; C031233:polihexanide; D002482:Cellulose; D012837:Silver Sulfadiazine