title: Impact of high-throughput screening in biomedical research.
abstract: High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for stifling the creativity that drug discovery demands. In this article, we aim to dispel these myths and present the case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes.
authors.affiliation: Department of Sample Management Technologies, GlaxoSmithKline, Mail Stop UP 12-200, 1250S Collegeville Rd, Collegeville, Pennsylvania 19426, USA. ricardo.macarron@gsk.com
authors.forename: Ricardo
authors.initials: R
authors.lastname: Macarron
authors.forename: Martyn N
authors.initials: MN
authors.lastname: Banks
authors.forename: Dejan
authors.initials: D
authors.lastname: Bojanic
authors.forename: David J
authors.initials: DJ
authors.lastname: Burns
authors.forename: Dragan A
authors.initials: DA
authors.lastname: Cirovic
authors.forename: Tina
authors.initials: T
authors.lastname: Garyantes
authors.forename: Darren V S
authors.initials: DV
authors.lastname: Green
authors.forename: Robert P
authors.initials: RP
authors.lastname: Hertzberg
authors.forename: William P
authors.initials: WP
authors.lastname: Janzen
authors.forename: Jeff W
authors.initials: JW
authors.lastname: Paslay
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schopfer
authors.forename: G Sitta
authors.initials: GS
authors.lastname: Sittampalam
mesh_terms: D000818:Animals; D035843:Biomedical Research; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000592:standards / Q000706:statistics & numerical data; D006801:Humans; D054852:Small Molecule Libraries
chemical_list: D054852:Small Molecule Libraries