title: Prevalence of diabetes mellitus, hyperinsulinaemia and metabolic syndrome among 755 adult patients with HIV-1 infection.
abstract: Metabolic complications of antiretroviral therapy in HIV-infected patients include insulin resistance, diabetes mellitus, dyslipidaemia and lipodystrophy syndrome. Metabolic syndrome is an aggregation of central obesity with glucose and lipid metabolism alterations that confers an increased risk of cardiovascular disease, which reproduces the antiretroviral-associated metabolic and morphological abnormalities. In this study, we report the prevalence of diabetes mellitus, hyperinsulinaemia and metabolic syndrome among 755 adult patients with HIV-1 infection referred to our outpatients unit. The prevalence of diabetes mellitus and metabolic syndrome was 4.5% and 9.1%, respectively. A longer exposure to antiretroviral therapy and a diagnosis of lipodystrophy syndrome were significantly associated with both metabolic disturbances.
authors.affiliation: Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, S. Orsola-Malpighi Hospital, Alma Mater Studiorum, University of Bologna, Bologna, Italy. leonardo.calza@unibo.it
authors.forename: L
authors.initials: L
authors.lastname: Calza
authors.forename: G
authors.initials: G
authors.lastname: Masetti
authors.forename: B
authors.initials: B
authors.lastname: Piergentili
authors.forename: F
authors.initials: F
authors.lastname: Trapani
authors.forename: A
authors.initials: A
authors.lastname: Cascavilla
authors.forename: R
authors.initials: R
authors.lastname: Manfredi
authors.forename: V
authors.initials: V
authors.lastname: Colangeli
authors.forename: P
authors.initials: P
authors.lastname: Viale
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000453:epidemiology*; D006801:Humans; D006946:Hyperinsulinism / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D019380:Anti-HIV Agents