title: A two-dimensional polarization interferometry based parallel scan angular surface plasmon resonance biosensor.
abstract: We describe a two-dimensional polarization interferometry based parallel scan angular surface plasmon resonance (SPR) biosensing technique. The method of line-shaped light illumination and parallel scan offers a high throughput. The simultaneous record of SPR angular spectrum enables the system to be unaffected by the time-dependent variation of the light source. The polarization interferometry technique lowers the minimum of the SPR dip and thereby reduces the noise related to the light intensity. Refractive index resolutions of 1.4 × 10(-6) refractive index unit (RIU) under normal condition and 4.6 × 10(-7) RIU under a more time-consuming condition are achieved in our angle interrogation based sensor. Meanwhile, a manually prepared DNA microarray has been detected, showing the potential applications of this technique in microarray analysis.
authors.affiliation: Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China.
authors.forename: Le
authors.initials: L
authors.lastname: Liu
authors.forename: Suihua
authors.initials: S
authors.lastname: Ma
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Ji
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Chong
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Liu
authors.forename: Yonghong
authors.initials: Y
authors.lastname: He
authors.forename: Jihua
authors.initials: J
authors.lastname: Guo
mesh_terms: D004271:DNA, Fungal / Q000235:genetics; D007368:Interferometry / Q000379:methods*; D008027:Light; D016014:Linear Models; D020411:Oligonucleotide Array Sequence Analysis; D020349:Surface Plasmon Resonance / Q000295:instrumentation*
chemical_list: D004271:DNA, Fungal