title: Congenital Pelger-Huët anomaly in a Danish/Swedish Farmdog: case report.
abstract: A 13 year old Danish/Swedish Farmdog from Denmark was evaluated in a veterinary clinic in Warsaw, Poland for evaluation of an orthopedic problem. Radiographs revealed spondylosis and degenerative vertebral disease, which responded to treatment with anti-inflammatory medications. A predominance of hyposegmented neutrophils and eosinophils containing condensed chromatin and normal cytoplasm were identified on a routine CBC. Follow-up blood film evaluations over the course of 12 months confirmed that the hyposegmented granulocytes persisted. The majority of neutrophils contained Grade 2 nuclei (slightly indented), and the mean nuclear score varied from 1.9 to 2.3. Pelger-Huët anomaly (PHA), presumably congenital, was diagnosed based on persistent hyposegmented granulocytes in the absence of an underlying cause for acquired PHA; genetically related dogs were unavailable for testing to confirm vertical transmission. To the authors' knowledge this is the first report of PHA in a Danish/Swedish Farmdog.
authors.affiliation: Veterinary Health Center, Wroclaw, Poland. janina.lukaszewska@neostrada.pl
authors.forename: Janina
authors.initials: J
authors.lastname: Lukaszewska
authors.forename: Robin W
authors.initials: RW
authors.lastname: Allison
authors.forename: Julita
authors.initials: J
authors.lastname: Stepkowska
mesh_terms: D000818:Animals; D003718:Denmark; D004283:Dog Diseases / Q000151:congenital* / Q000473:pathology; D004285:Dogs; D004804:Eosinophils / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000473:pathology; D010381:Pelger-Huet Anomaly / Q000151:congenital / Q000662:veterinary*