title: Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia.
abstract: Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier. However, despite 16 years of research on a number of central nervous system disorders, an effective treatment using this strategy has only been observed in the brain tumor glioblastoma multiforme. Within this study we propose a novel system for delivering drugs into the brain named the simple diffusion (SDD) system. To validate this technique, rats were subjected to a single intracranial (at the caudate nucleus), or intraperitoneal injection, of the compound citicoline, followed two hours later by a permanent middle cerebral artery occlusion (pMCAO). Results showed that 12 h after pMCAO, with 0.0025 g kg(-1) citicoline, an infarct volume 1/6 the size of the intraperitoneal group was achieved with a dose 1/800 of that required for the intraperitoneal group. These results suggest that given the appropriate injection point, through SDD a pharmacologically effective concentration of citicoline can be administered.
authors.affiliation: Department of Radiology, Peking University Third Hospital, Beijing 100191, China. hanhongbin@bjmu.edu.cn
authors.forename: Hongbin
authors.initials: H
authors.lastname: Han
authors.forename: Zuoli
authors.initials: Z
authors.lastname: Xia
authors.forename: He
authors.initials: H
authors.lastname: Chen
authors.forename: Chao
authors.initials: C
authors.lastname: Hou
authors.forename: Weibo
authors.initials: W
authors.lastname: Li
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D003566:Cytidine Diphosphate Choline / Q000008:administration & dosage* / Q000627:therapeutic use*; D004058:Diffusion; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D018697:Nootropic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018697:Nootropic Agents; D003566:Cytidine Diphosphate Choline