title: [Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues].
abstract: Resveratrol, isorhapontigenin and pinosylvin, isolated from Gnetum parvifolium, and their analogues have been synthesized and tested for their inhibitory activity of HIV-1. Natural product 12a and analogues (12d, 12e, 12g) display significant inhibitory activity of HIV-1 replication. Among them, compound 12d (trans-3, 4, 5, 4'-tetrahydroxystilbene) exhibits the most potent anti-HIV-1 activity with an IC50 value of 1.84 micromol x L(-1).
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Zhi-song
authors.initials: ZS
authors.lastname: Piao
authors.forename: Ya-bing
authors.initials: YB
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Xing-quan
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Mao
authors.initials: M
authors.lastname: Lin
mesh_terms: D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D035684:Gnetum / Q000737:chemistry; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D020128:Inhibitory Concentration 50; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000821:virology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*; D000094162:Phytoalexins
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D000077185:Resveratrol; D013267:Stilbenes; C422863:3,4,5,4'-tetrahydroxystilbene; C432307:isorhapontigenin; C049032:pinosylvin; D000094162:Phytoalexins