title: Multivariate analysis of wound complications after surgery for laryngeal and hypopharyngeal cancers.
abstract: OBJECTIVE
  The aim of this study was to identify the factors leading to postoperative complications following surgical management of laryngeal and hypopharyngeal cancers.
  
  
  METHODS
  Between 2001 and 2008, the medical records of 107 laryngeal and hypopharyngeal cancer patients requiring laryngectomy or pharyngolaryngectomy at our hospital were reviewed. The incidence of wound complications and correlation of complications with clinicopathological factors were investigated by univariate and multivariate analysis.
  
  
  RESULTS
  The overall incidence of wound complication was 33.6%. The complication incidence was 35.2, 21.7 and 46.2% for the primary surgery, radiation and chemoradiation groups, respectively. Diabetes mellitus and bilateral paratracheal node dissection were significantly correlated and were independent risk factors according to multivariate analysis. Bleeding from a large vessel occurred in 4 patients, and there were significant correlations with chemoradiation.
  
  
  CONCLUSIONS
  Preoperative chemoradiation was not a significant risk factor for wound complication in this study. However, once postoperative wound complications occurred, they tended to produce lethal outcomes.
authors.affiliation: Department of Otolaryngology, Tokai University, School of Medicine, Isehara, Japan. asakai-ygc@umin.ac.jp
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sakai
authors.forename: Kenji
authors.initials: K
authors.lastname: Okami
authors.forename: Ryousuke
authors.initials: R
authors.lastname: Sugimoto
authors.forename: Koji
authors.initials: K
authors.lastname: Ebisumoto
authors.forename: Hikaru
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Furuya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D005260:Female; D005402:Fistula / Q000453:epidemiology; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000453:epidemiology* / Q000532:radiotherapy / Q000601:surgery*; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000453:epidemiology* / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy / Q000009:adverse effects; D008197:Lymph Node Excision / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology*; D011832:Radiation Injuries / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors