title: [Meta-analysis of the relationship between polymorphisms of 399 point of X-ray repair cross complementing gene group 1 and hepatocellular carcinoma].
abstract: OBJECTIVE
  Discuss the relationship between the X-ray repair cross complementing gene group 1 (XRCC1) 399 point polymorphisms and risk of hepatocellular carcinoma occurrence.
  
  
  METHODS
  Search the domestic and abroad database to obtain the related cases of XRCC1 gene polymorphisms and risk of hepatocellular carcinoma occurrence, and use the analysis software Review Manager 4. 2. 8 to perform the comprehensive statistic processing and heterogeneity test for each research data included in this meta analysis and calculate the combined OR value (with 95% CI).
  
  
  RESULTS
  There were 7 literatures conformed to the inclusion criteria. A total of 1133 hepatocellular carcinoma cases and 1747 control cases were included. The meta analysis results showed that compared with the wild-type homozygous Arg/Arg, the combined OR (95% CI) of variant heterozygous genotype Arg/Gln and (Arg/Gln + Gln/Gln) were both 1.00 (0.68, 1.47), and the combined OR (95% CI) of variant homozygous genotype was 1.02 (0.60, 1.72). The relationship between XRCC1 399 point polymorphisms and the risk of hepatocellular carcinoma occurrence was of no statistical significance.
  
  
  CONCLUSIONS
  No statistically significant relationship between the genotype of XRCC1 399 point polymorphism and the risk of hepatocellular carcinoma occurrence was found.
authors.affiliation: College of Public Health, Zhengzhou University, Zhengzhou 450001, China. zhnlfm@163.com
authors.forename: Huina
authors.initials: H
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Dai
authors.forename: Kaijuan
authors.initials: K
authors.lastname: Wang
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Yun
authors.forename: Jianying
authors.initials: J
authors.lastname: Zhang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human