title: Reproducibility of fMRI activations during a story listening task in patients with schizophrenia.
abstract: A prerequisite to longitudinal fMRI studies in schizophrenia is the knowledge on fMRI signal reliability in schizophrenia patients. We assessed the reproducibility of activations elicited by two fMRI sessions, which were 21 months apart, of a story listening paradigm in 10 schizophrenia patients and 10 healthy subjects. In both groups, we observed a high degree of spatial overlap of activation maps as well as a good reproducibility of signal variations assessed on a voxel-wise basis in temporal areas underlying early stages of language processing. Task performance, assessed through a comprehension questionnaire, had no impact on the activation reproducibility.
authors.affiliation: Centre d'Imagerie-Neurosciences et Applications aux Pathologies, UMR 6232 CNRS, CEA, Universités de Caen & Paris Descartes, Caen, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Maïza
authors.forename: Bernard
authors.initials: B
authors.lastname: Mazoyer
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Hervé
authors.forename: Annick
authors.initials: A
authors.lastname: Razafimandimby
authors.forename: Sonia
authors.initials: S
authors.lastname: Dollfus
authors.forename: Nathalie
authors.initials: N
authors.lastname: Tzourio-Mazoyer
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology; D001931:Brain Mapping; D032882:Comprehension / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007802:Language; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000473:pathology*; D012565:Schizophrenic Psychology; D055815:Young Adult
chemical_list: D010100:Oxygen