title: Administration of the combination clonazepam-Deanxit as treatment for tinnitus.
abstract: OBJECTIVE
  Present study investigates the combination of Deanxit and clonazepam (Rivotril) intake for relief of tinnitus complaints, respecting a double-blind placebo-controlled approach for Deanxit in a crossover setup.
  
  
  BACKGROUND
  Although several pharmacologic treatments--including antidepressants, prostaglandins, and aminobutyric acid (GABA)-active drugs--were already presented as promising in tinnitus treatment, no drug has yet been approved by the Food and Drug Administration and European Medicine Agency for the treatment of tinnitus.
  
  
  METHODS
  Patients were randomly assigned to patient group A or patient group B in a double-blind way. Patient group A first received 3 weeks of Deanxit, followed by 1 week of washout and 3 weeks of placebo. Treatment was given in opposite order to subjects from Patient group B.All patients received a daily treatment consisting of clonazepam 1 mg once daily, starting on Day 1.
  
  
  RESULTS
  Significant tinnitus reduction was seen after intake of the combination clonazepam-Deanxit, whereas no differences in tinnitus could be demonstrated after the administration of clonazepam-placebo. This was true for all patients according to the following parameters: time patients are annoyed by the tinnitus (p = 0.026) and the visual analogue scale for tinnitus annoyance (p = 0.024).
  
  
  CONCLUSIONS
  Although tinnitus reduction was recorded as modest, this article provides valuable data demonstrating a placebo-controlled tinnitus reduction after clonazepam and Deanxit intake.
authors.affiliation: University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital (UZA), University of Antwerp, Antwerp, Belgium. oliviermeeus@uza.be
authors.forename: Olivier
authors.initials: O
authors.lastname: Meeus
authors.forename: Dirk
authors.initials: D
authors.lastname: De Ridder
authors.forename: Paul
authors.initials: P
authors.lastname: Van de Heyning
mesh_terms: D000328:Adult; D000873:Anthracenes / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005475:Flupenthixol / Q000627:therapeutic use*; D018757:GABA Modulators / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D014012:Tinnitus / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000873:Anthracenes; D004338:Drug Combinations; D018757:GABA Modulators; C000851:flupentixol, melitracen drug combination; D002998:Clonazepam; D005475:Flupenthixol