title: [Protective effect of extract of Apocynum venetum on kidneys of streptozotocin-induced diabetic rats].
abstract: The aim of this study is to investigate the effects and mechanism of extract of Apocynum venetum (AV) on kidneys of streptozotocin-induced diabetic rats. Diabetes mellitus (DM) was induced in rats by intraperitoneal injection of streptozotocin (STZ). The indexes of the blood glucose, renal function and oxidative stress were observed. The DM rats were administrated with the AV for 8 weeks, the above-mentioned indexes were detected. The blood glucose level, BUN, 24 h urine protein excretion, urine volume, renal index, renal cortex's MDA level in model groups all increased significantly. Renal cortex's SOD and GSH activities decreased significantly compared with the normal control group (P < 0.05). The above-mentioned indexes were significantly improved by the AV treatment (P < 0.05). AV have protective effects on renal function of kidneys of streptozotocin-induced diabetic rats, and maybe via inhibition of the renal oxidative stress.
authors.affiliation: Institute of Geriatrics, Chinese PLA General Hospital, Beijing 100853, China. hongychen@sina.com
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Chen
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Wang
authors.forename: Miao
authors.initials: M
authors.lastname: Geng
authors.forename: Xiang-Qi
authors.initials: XQ
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Kai
authors.initials: K
authors.lastname: Huang
authors.forename: Li-Mian
authors.initials: LM
authors.lastname: Shao
authors.forename: Xin-Bo
authors.initials: XB
authors.lastname: Yang
authors.forename: Zheng-Ming
authors.initials: ZM
authors.lastname: Huang
mesh_terms: D000818:Animals; D030010:Apocynum / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D019270:Fructosamine / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D007668:Kidney / Q000503:physiopathology; D007672:Kidney Cortex / Q000473:pathology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D019270:Fructosamine; D008315:Malondialdehyde; D003404:Creatinine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase