title: Cytotoxic triterpenoid saponins from the rhizomes of Anemone taipaiensis.
abstract: Two new oleanane-type triterpenoid saponins, 1 and 2, and a new natural product, 3, together with five known saponins, 4- 8, were isolated from the rhizomes of ANEMONE TAIPAIENSIS. Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. Six saponins, 1, 2, 4- 7, which possessed a free carboxylic group at C-28, exhibited significant cytotoxicity against human leukemia HL-60 cells and human hepatocellular carcinoma Hep-G2 cells with IC (50) values in the range of 1.31-10.12 µM.
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, P. R. China.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Wang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Chen
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Tian
authors.forename: Ping-Hu
authors.initials: PH
authors.lastname: Zhang
mesh_terms: D031883:Anemone / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D006801:Humans; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; C413246:oleanane; D009828:Oleanolic Acid