title: [Formation mechanism and the function of parasitophorous vacuole of Toxoplasma gondii].
abstract: Toxoplasma gondii is a ubiquitous, obligate intracellular protozoan parasite in human and animals. Chronic infection with this parasite is likely one of the most common infection in human. Following invasion of host cells T gondii resides within membrane-bound vacuoles known as parasitophorous vacuole (PV), which can protect the parasite from the endosomal acidification and lysosomal fusion of host cells. It plays an essential role in the whole parasitic process of T. gondii. This review summarizes the mechanism of PV formation and its function in the host cells.
authors.affiliation: Department of Etio-biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China. floriapeng@hotmail.com
authors.forename: Hong-Juan
authors.initials: HJ
authors.lastname: Peng
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006790:Host-Parasite Interactions; D006801:Humans; D014122:Toxoplasma / Q000254:growth & development* / Q000472:pathogenicity* / Q000502:physiology; D014617:Vacuoles / Q000502:physiology*