title: Superoxide generation catalyzed by the ozone-inducible plant peptides analogous to prion octarepeat motif.
abstract: Ozone-inducible (OI) peptides found in plants contain repeated sequences consisting of a hexa-repeat unit (YGH GGG) repeated 7-9 times in tandem, and each unit tightly binds copper. To date, the biochemical roles for OI peptides are not fully understood. Here, we demonstrated that the hexa-repeat unit from OI peptides behaves as metal-binding motif catalytically active in the O2•--generation. Lastly, possible mechanisms of the reaction and biological consequence of the reactions are discussed by analogy to the action of human prion octarepeat peptides.
authors.affiliation: The University of Kitakyushu, Hibikino, Fukuoka, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Yokawa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kagenishi
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kawano
mesh_terms: D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D008954:Models, Biological; D010126:Ozone / Q000633:toxicity*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D010944:Plants / Q000187:drug effects* / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
chemical_list: D010455:Peptides; D013481:Superoxides; D010126:Ozone