title: Agnosic or semantic impairment in very mild Alzheimer's disease?
abstract: The present study investigated object recognition impairment and the existence of category effects in patients with mild Alzheimer's disease. A battery of tests was designed to assess the deterioration of semantic memory and/or the existence of agnosia by evaluating visual and auditory naming, knowledge of structural descriptions (pre-semantic representation of an object within each perceptual system) and conceptual knowledge. The group of Alzheimer's patients were impaired in all experimental tests as compared to healthy participants. This result suggests an impairment of multiple levels of object integration processing even at an early stage of the disease. The patients also demonstrated a category effect with massive difficulties in recognizing human actions and musical instruments as compared to the other categories. This study provides an innovative clinical tool for exploring the recognition of visual and auditory objects at different levels of representation, allowing for the description of early signs of Alzheimer disease.
authors.affiliation: Service de Neurologie & CMRR Champagne-Ardenne, Centre Hospitalier Universitaire de Reims, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Goudour
authors.forename: Severine
authors.initials: S
authors.lastname: Samson
authors.forename: Serge
authors.initials: S
authors.lastname: Bakchine
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ehrle
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D000369:Aged, 80 and over; D000377:Agnosia / Q000175:diagnosis / Q000209:etiology*; D000544:Alzheimer Disease / Q000150:complications*; D005260:Female; D006801:Humans; D019359:Knowledge; D007806:Language Disorders / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009275:Names; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D012660:Semantics; D013223:Statistics as Topic