title: Decreased serum creatinine concentration is associated with short telomeres of adipose tissue cells.
abstract: Decreased serum creatinine concentration has been recently described to constitute a new risk factor of type 2 diabetes. Increased free radicals have been consistently associated with decreased serum creatinine and with cellular senescence. Telomere length is considered as a biological marker for senescence. We aimed to study the association of telomere length with serum creatinine. Telomere length of subcutaneous adipose tissue cells was measured in a sample of obese and nonobese subjects (n = 49). Telomere length of subcutaneous adipose tissue cells was positively associated with serum creatinine (r = 0.40, P = 0.004), i.e., the lower the telomere length, the lower the serum creatinine, but not with glomerular filtration rate (GFR). In addition, telomere length was negatively associated with BMI (r = -0.45, P = 0.001) and systolic blood pressure (r = -0.41, P = 0.003). In a multiple linear regression analysis, BMI (P = 0.005), systolic blood pressure (P = 0.01) and telomere length (P = 0.03) independently contributed to 37% of serum creatinine variance after controlling for sex and age. In conclusion, the association of serum creatinine with a marker of cellular senescence suggests an underlying mechanism influencing both decreased serum creatinine and increased risk of type 2 diabetes.
authors.affiliation: Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomédica de Girona, CIBERobn Fisiopatología de la Obesidad y Nutrición CB06/03/010, Girona, Spain. jmfernandezreal.girona.ics@gencat.cat
authors.forename: J M
authors.initials: JM
authors.lastname: Fernández-Real
authors.forename: J M
authors.initials: JM
authors.lastname: Moreno-Navarrete
authors.forename: F
authors.initials: F
authors.lastname: Ortega
authors.forename: W
authors.initials: W
authors.lastname: Ricart
mesh_terms: D017667:Adipocytes / Q000648:ultrastructure*; D000328:Adult; D015415:Biomarkers; D015992:Body Mass Index; D016922:Cellular Senescence; D003404:Creatinine / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000473:pathology* / Q000503:physiopathology; D018384:Oxidative Stress; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D050507:Subcutaneous Fat, Abdominal / Q000473:pathology; D016615:Telomere / Q000648:ultrastructure*
chemical_list: D015415:Biomarkers; D003404:Creatinine