title: Copper-catalyzed domino synthesis of quinazolinones via Ullmann-type coupling and aerobic oxidative C-H amidation.
abstract: An efficient copper-catalyzed approach to quinazolinone derivatives has been developed, and the protocol uses cheap and readily available substituted 2-halobenzamides and (aryl)methanamines as the starting materials as well as economical and environmentally friendly air as the oxidant. This can be the first example of constructing N-heterocycles via sequential Ullmann-type coupling under air and aerobic oxidative C-H amidation.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Yibao
authors.initials: Y
authors.lastname: Jin
authors.forename: Hongxia
authors.initials: H
authors.lastname: Liu
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
mesh_terms: D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001549:Benzamides; D006846:Hydrocarbons, Halogenated; D052999:Quinazolinones; D003300:Copper