title: Performance of radiological methods in diagnosing hepatocellular carcinoma preoperatively in a recipient of living related liver transplantation: comparison with step section histopathology.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the performance of multidetector-row CT (MDCT) and magnetic resonance imaging (MRI) in diagnosing hepatocellular carcinoma (HCC) preoperatively in living related liver transplantation (LRLT) recipients with liver cirrhosis and HCC.
  
  
  METHODS
  A total of 25 LRLT recipients with 89 pathologically proved HCCs underwent dynamic 4-row MDCT (5 mm collimation) and MRI within 1 month before LRLT. The images were reviewed for the diagnosis of HCC on a tumor-by-tumor basis by three observers independently and randomly using explanted specimens as the gold standard. The diagnostic accuracy of these techniques in the detection of HCC was assessed with alternative free response receiver operating characteristic (ROC) analysis. The sensitivity and positive predictive values were evaluated.
  
  
  RESULTS
  The average values of the area under the ROC curve (Az) of MRI images were higher than those obtained with MDCT; however, no significant difference was observed (P > 0.05). The overall sensitivity of HCC with MRI was higher than that with MDCT, especially in the case of HCCs <20 mm.
  
  
  CONCLUSIONS
  A better diagnostic performance regarding HCCs in LRLT recipients was achieved with MRI than with MDCT, although no significant difference was observed.
authors.affiliation: Department of Clinical Radiology, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Fukuoka, Japan. mahira@radiol.med.kyushu-u.ac.jp
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hirakawa
authors.forename: Kengo
authors.initials: K
authors.lastname: Yoshimitsu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Irie
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tajima
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nishie
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Asayama
authors.forename: Kousei
authors.initials: K
authors.lastname: Ishigami
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kakihara
authors.forename: Akinobu
authors.initials: A
authors.lastname: Taketomi
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Aishima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D016031:Liver Transplantation; D019520:Living Donors; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011237:Predictive Value of Tests; D057234:Preoperative Period; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*