title: [Transurethral resection of the prostate for advanced hormone-refractory prostate cancer: a feasibility study].
abstract: OBJECTIVE
  To investigate the effect of transurethral resection of the prostate (TURP) in the treatment of advanced prostate cancer with bladder outlet obstruction (BOO).
  
  
  METHODS
  We included in this study 43 cases of advanced prostate cancer with BOO treated by TURP, and analyzed their IPSS, maximum urinary flow rate and relevant risk factors pre-operatively and at 3 and 12 months after TURP.
  
  
  RESULTS
  Compared with the baseline, IPSS and the maximum urinary flow rate of the patients showed significant differences 3 months after surgery ([19.60 +/- 0.41] score vs. [9.58 +/- 0.33] score, [4.93 +/- 0.68] ml/s vs. [8.96 +/- 0.47] ml/s, P < 0.05), but not at 12 months ([15.73 +/- 0.66] score, [5.67 +/- 0.44] ml/s). In multiple regression analysis, a good outcome was associated with pre-operative acute urinary retention, while poor prognosis with hormone-refractory prostate cancer.
  
  
  CONCLUSIONS
  In the treatment of advanced hormone-refractory prostate cancer with BOO, TURP can reduce IPSS and increase the maximum urinary flow rate in the early period after surgery, but its long-term effect is not so desirable. Meanwhile the operation itself may bring about relevant complications and reduce the patient's quality of life.
authors.affiliation: Department of Urology, Zhongshan Hospital Affiliated to Dalian University, Dalian, Liaoning 116001, China. yangjanxun@hotmail.com
authors.forename: Jian-xun
authors.initials: JX
authors.lastname: Yang
authors.forename: Qi-zhong
authors.initials: QZ
authors.lastname: Fu
authors.forename: Guang-yao
authors.initials: GY
authors.lastname: Lü
authors.forename: Sheng-fang
authors.initials: SF
authors.lastname: Dong
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005240:Feasibility Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000601:surgery*; D020728:Transurethral Resection of Prostate; D016896:Treatment Outcome; D001748:Urinary Bladder Neck Obstruction / Q000601:surgery