title: Estimation of liver function using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance imaging.
abstract: OBJECTIVE
  To investigate the ability of T1 mapping of liver on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the estimation of liver function.
  
  
  METHODS
  Local institutional review board approved this study. Ninety-one patients (64 men, 27 women; mean age, 67.4 years) were classified into 4 groups as follows: normal liver function (NLF), n = 16; chronic hepatitis (CH), n = 38; liver cirrhosis with Child-Pugh A (LCA), n = 20; and liver cirrhosis with Child-Pugh B (LCB), n = 17. Look-Locker sequences (single slice multiphase imaging using gradient-echo sequence with inversion recovery pulse) were obtained before and at 3, 8, 13, and 18 minutes after Gd-EOB-DTPA administration. T1 mapping of liver parenchyma was calculated from the Look-Locker sequence. T1 relaxation time of liver and reduction rate of T1 relaxation time between pre- and postcontrast enhancement were measured. The Bonferroni t test was used for comparisons between the 4 groups.
  
  
  RESULTS
  Precontrast T1 relaxation times were significantly longer for LCA and LCB than for NLF, and that of LCB was longer than that of chronic hepatitis (P < 0.05). Postcontrast T1 relaxation times were significantly longer for LCB than for other groups at all time points. Those of LCA were longer than those of NLF at all time points. Reduction rates were significantly lower for LCB than for the other groups at ≥8 minutes.
  
  
  CONCLUSIONS
  Evaluation of hepatic uptake of Gd-EOB-DTPA using T1 mapping of liver parenchyma can help estimate liver function.
authors.affiliation: Department of Radiology, Kinki University Faculty of Medicine, Osaka, [corrected] Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Katsube
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okada
authors.forename: Seishi
authors.initials: S
authors.lastname: Kumano
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hori
authors.forename: Izumi
authors.initials: I
authors.lastname: Imaoka
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ishii
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kudo
authors.forename: Hajime
authors.initials: H
authors.lastname: Kitagaki
authors.forename: Takamichi
authors.initials: T
authors.lastname: Murakami
mesh_terms: D000368:Aged; D003287:Contrast Media / Q000378:metabolism*; D005260:Female; D019786:Gadolinium DTPA / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis*; D008111:Liver Function Tests / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA