title: Intravenous lacosamide--an effective add-on treatment of refractory status epilepticus.
abstract: Status epilepticus (SE) is a frequent neurological emergency requiring immediate treatment. Therapy usually requires intravenous anticonvulsive medication. Lacosamide is a novel anticonvulsant drug that is available as infusion solution. We describe seven patients with focal SE who were treated with intravenous Lacosamide. All patients in our case series were unsuccessfully treated with other antiepileptic drugs before Lacosamide i.v. was added. In all cases, SE was terminated within 24 h after Lacosamide. There were no serious side effects or adverse events attributable to Lacosamide i.v. Our data suggest that Lacosamide might be an effective add-on treatment, if standard drugs fail or are unsuitable.
authors.affiliation: Department of Neurology, University Hospital Muenster, Germany. albersjo@uni-muenster.de
authors.forename: Johannes Michael
authors.initials: JM
authors.lastname: Albers
authors.forename: Gabriel
authors.initials: G
authors.lastname: Möddel
authors.forename: Ralf
authors.initials: R
authors.lastname: Dittrich
authors.forename: Corinna
authors.initials: C
authors.lastname: Steidl
authors.forename: Sonja
authors.initials: S
authors.lastname: Suntrup
authors.forename: Erich Bernd
authors.initials: EB
authors.lastname: Ringelstein
authors.forename: Rainer
authors.initials: R
authors.lastname: Dziewas
mesh_terms: D000081:Acetamides / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D000078334:Lacosamide; D008297:Male; D008875:Middle Aged; D013226:Status Epilepticus / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide