title: Poly(diol-co-citrate)s as novel elastomeric perivascular wraps for the reduction of neointimal hyperplasia.
abstract: The synthesis of poly(diol-co-citrate) elastomers that are biocompatible with vascular cells and can modulate the kinetics of the NO release based on the diol of selection is reported. NO-mediated cytostatic or cytotoxic effects can be controlled depending on the NO dose and the exposure time. When implanted in vivo in a rat carotid artery injury model, these materials demonstrate a significant reduction of neointimal hyperplasia. This is the first report of a NO-releasing polymer fabricated in the form of an elastomeric perivascular wrap for the treatment of neointimal hyperplasia. These elastomers also show promise for other cardiovascular pathologies where NO-based therapies could be beneficial.
authors.affiliation: Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA.
authors.forename: M Concepcion
authors.initials: MC
authors.lastname: Serrano
authors.forename: Ashley K
authors.initials: AK
authors.lastname: Vavra
authors.forename: Michele
authors.initials: M
authors.lastname: Jen
authors.forename: Melissa E
authors.initials: ME
authors.lastname: Hogg
authors.forename: Jozef
authors.initials: J
authors.lastname: Murar
authors.forename: Janet
authors.initials: J
authors.lastname: Martinez
authors.forename: Larry K
authors.initials: LK
authors.lastname: Keefer
authors.forename: Guillermo A
authors.initials: GA
authors.lastname: Ameer
authors.forename: Melina R
authors.initials: MR
authors.lastname: Kibbe
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D020212:Carotid Artery Injuries / Q000188:drug therapy / Q000473:pathology; D017536:Carotid Artery, Common / Q000187:drug effects / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020724:Elastomers / Q000737:chemistry*; D006801:Humans; D006965:Hyperplasia / Q000517:prevention & control; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing; D058426:Neointima / Q000473:pathology*; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000008:administration & dosage / Q000494:pharmacology*; D011091:Polyesters / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013718:Tensile Strength; D014226:Triazenes / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020724:Elastomers; D020030:Nitric Oxide Donors; D011091:Polyesters; D014226:Triazenes; D009569:Nitric Oxide