title: [Catechol-O-methyltransferase gene rs6267 polymorphism in children with attention deficit hyperactivity disorder].
abstract: OBJECTIVE
  To study the relationship between rs6267 polymorphism of catechol-O-methyltransferase (COMT) gene and attention deficit hyperactivity disorder (ADHD).
  
  
  METHODS
  One hundred and fourteen children with ADHD and 76 normal volunteers were enrolled. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques were used for detecting COMT rs6267 polymorphism. The behavioral problems were assessed by Child Behavior Checklist (CBCL).
  
  
  RESULTS
  There were no significant differences in the COMT genotype distribution and allele frequencies between the ADHD and normal control groups. The frequencies of thinking problems (1.7±1.9 vs 1.0±0.9) and disciplinary problems (4.5±3.7 vs 2.2±1.4) in ADHD children carrying genotype G/G were significantly higher than those in children carrying G/T (P<0.05).
  
  
  CONCLUSIONS
  COMT rs6267 polymorphism may not contribute to susceptibility to ADHD. However, there might be an association between rs6267 polymorphism and some clinical characters of ADHD.
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Yue-Bing
authors.initials: YB
authors.lastname: Zhang
authors.forename: Xue-Rong
authors.initials: XR
authors.lastname: Luo
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhong
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Lei-Yin
authors.initials: LY
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D002394:Catechol O-Methyltransferase