title: Validation of VASO cerebral blood volume measurement with positron emission tomography.
abstract: Cerebral blood volume (CBV) has been shown to be an important biomarker in a number of neurological disorders and in the quantitative interpretation of functional MRI. One approach to determine CBV in humans is vascular-space-occupancy MRI, and this technique has been applied to the studies of brain glioma, Schizophrenia, and Alzheimer's disease. However, validation of this technique with a gold standard method has not been reported. In this study, we compared vascular-space-occupancy MRI with a radiotracer-based positron emission tomography technique in a group of healthy subjects. It was found that regional CBV measured with vascular-space-occupancy MRI was highly correlated with that of the positron emission tomography data (R=0.79±0.10, N=8). Furthermore, absolute CBV values quantified by vascular-space-occupancy were also in excellent agreement with those by positron emission tomography (slope=1.00±0.15). Because of the differences in the labeling principles between the two modalities, systematic CBV differences were observed in large vessel and ventricle regions.
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Jinsoo
authors.initials: J
authors.lastname: Uh
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Lin
authors.forename: Kihak
authors.initials: K
authors.lastname: Lee
authors.forename: Peiying
authors.initials: P
authors.lastname: Liu
authors.forename: Peter
authors.initials: P
authors.lastname: Fox
authors.forename: Hanzhang
authors.initials: H
authors.lastname: Lu
mesh_terms: D000328:Adult; D001810:Blood Volume / Q000502:physiology*; D001811:Blood Volume Determination / Q000379:methods*; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology* / Q000528:radiation effects; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity