title: Lehualides E-K, cytotoxic metabolites from the Tongan marine sponge Plakortis sp.
abstract: Spectroscopy-guided chemical analysis of a marine sponge from the genus Plakortis, collected in Tonga, yielded seven new metabolites of polyketide origin, lehualides E-K (5-11), four of which incorporate various sulfur functionalities. The structures of compounds 5-11 were elucidated by interpretation of spectroscopic data and spectral comparison with model compounds. The biological activities of compounds 6-9 were investigated against human promyeloid leukemic HL-60 cells and two yeast strains, wild-type and a drug-sensitive mutant.
authors.affiliation: Centre for Biodiscovery and School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Barber
authors.forename: Natelle C H
authors.initials: NC
authors.lastname: Quek
authors.forename: Dora C
authors.initials: DC
authors.lastname: Leahy
authors.forename: John H
authors.initials: JH
authors.lastname: Miller
authors.forename: David S
authors.initials: DS
authors.lastname: Bellows
authors.forename: Peter T
authors.initials: PT
authors.lastname: Northcote
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D047229:Plakortis / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D014058:Tonga
chemical_list: D000970:Antineoplastic Agents; D011753:Pyrones; C559104:lehualide F