title: [Improvement of the pharmacological activity of nifedipine by mechanochemical complexation with glycyrrhizic acid].
abstract: A new water-soluble form of the calcium blocker nifedipine (NF) with glycyrrhizic acid (GA) (with molecular ratio 1:4) has been obtained by mechanochemical synthesis. Its pharmacological advantages in comparison with nifedipine were determined. An effective dose of nifedipine in complex reduced to 10 times as compared to its therapeutic dose while high antihypertensive activity preservation and pleiotropic antiarhythmic activity enhancement. This new antihypertensive and antiarhythmic agent (complex of NF:GA = 1:4) is chemically stable and safe for parenteral administration.
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: M V
authors.initials: MV
authors.lastname: Khvostov
authors.forename: A O
authors.initials: AO
authors.lastname: Bryzgalov
authors.forename: A V
authors.initials: AV
authors.lastname: Dushkin
authors.forename: E S
authors.initials: ES
authors.lastname: Meteleva
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D019695:Glycyrrhizic Acid / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D055595:Mechanical Phenomena; D009543:Nifedipine / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000959:Antihypertensive Agents; D019695:Glycyrrhizic Acid; D009543:Nifedipine