title: [Chronic cerebrovascular diseases, metabolic syndrome and the status of hemorrheological and hemostatic systems].
abstract: OBJECTIVE
  to study an association between metabolic syndrome and endothelial dysfunction as a regulator of hemorrheological and hemostatic processes in patients with chronic forms of cerebral circulatory insufficiency.
  
  
  METHODS
  Forty-six patients with chronic cerebrovascular diseases (CCVD) were examined; of them 23 patients were diagnosed as having metabolic syndrome (MS). Clinical manifestations and major hemorrheological and hemostatic parameters, such as platelet and erythrocyte aggregation, fibrinogen, hematocrit, von Willebrand factor, antithrombin III, intercellular adhesion molecules (IAM), etc., were estimated. Endothelial dysfunction was studied from the data of cuff test (CT).
  
  
  RESULTS
  MS promotes a higher degree of clinical symptomatology in patients with CCVD and more significant impairments in the hemorrheological and hemostatic systems. CT has shown that all the patients have an inadequate endothelial reaction - the antiaggregatory, fibrinolytic, and anticoagulant activities of the endothelium are lowered. There was endothelium-dependent hyperproduction of IAM.
  
  
  CONCLUSIONS
  The found changes suggest that MS has a considerable impact on the formation of a significant procoagulant state of the hemorrheological and hemostatic systems in patients with CCVD.
authors.forename: M M
authors.initials: MM
authors.lastname: Tanashian
authors.forename: V G
authors.initials: VG
authors.lastname: Ionova
authors.forename: S V
authors.initials: SV
authors.lastname: Orlov
authors.forename: N G
authors.initials: NG
authors.lastname: Omel'chenko
authors.forename: A A
authors.initials: AA
authors.lastname: Shabalina
authors.forename: M V
authors.initials: MV
authors.lastname: Kostyreva
mesh_terms: D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D018056:Hemorheology / Q000502:physiology*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D008875:Middle Aged