title: Pulsed magnetic fields enhance the rate of recovery of damaged nerve excitability.
abstract: Pulsed magnetic fields (PMFs) have well-known beneficial effects on nerve regeneration. However, little research has examined the nerve conduction characteristics of regenerating peripheral nerves under PMF. The main goal of this study was to examine the conduction characteristics of regenerating peripheral nerves under PMFs. The sucrose-gap recording technique was used to examine the conduction properties of injured sciatic nerves of rats exposed to PMF. Following the injury, peripheral nerves were very sensitive to repetitive stimulation. When the stimulation frequency was increased, the amplitude of the compound action potential (CAP) decreased more at 15 days post-crush injury (dpc) than at 38 dpc. PMF treatment for 38 days after injury caused significant differences in the conduction of CAPs. Moreover, application of PMF ameliorated the abnormal electrophysiological activities of nerves such as hyperpolarizing afterpotentials and delayed depolarizations that were revealed by 4-aminopyridine (4-AP). Consequently, characteristic findings in impulse conduction of recovered nerves under PMF indicate that the observed abnormalities in signaling or aberrant ion channel functions following injury may be restored by PMF application.
authors.affiliation: Department of Biophysics, School of Medicine, University of Cukurova, Balcali, Adana, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Gunay
authors.forename: Tufan
authors.initials: T
authors.lastname: Mert
mesh_terms: D015761:4-Aminopyridine / Q000494:pharmacology; D000818:Animals; D055724:Electrophysiological Phenomena / Q000187:drug effects; D005260:Female; D055909:Magnetic Field Therapy; D008280:Magnetics; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000502:physiology* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology*
chemical_list: D015761:4-Aminopyridine