title: [Hypothesis for the formation of human unresponsiveness to immunodeficiency virus].
abstract: The paper reviews data on the genetics of various pathogens and the specific features of their host interactions. Particular emphasis is laid on human immunodeficiency virus (HIV-1), its origin theory, the time and site of its primary manifestations. The mechanism of human protection against HIV, in which the leading role is played by CCR5 receptor mutations, mutant receptor CCR5-32 in particular, is considered. The extra-African origin of HIV is hypothesized.
authors.forename: V P
authors.initials: VP
authors.lastname: Sergiev
mesh_terms: D004279:DNA, Viral / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic
chemical_list: D004279:DNA, Viral