title: Hepatic arterial infusion (HAI) with PEGylated liposomes containing 5-FU improves tumor control of liver metastases in a rat model.
abstract: OBJECTIVE
  To investigate the cytostatic effect of 5-fluorouracil (5-FU) encapsulated in polyethylene glycol (PEG) liposomes with or without degradable starch microspheres (DSM) in a long-term trial using a rat liver tumor model.
  
  
  METHODS
  The cytostatics were applied once either as a hepatic arterial infusion (HAI) or were systemically infused via the tail vein. Seven groups were compared with respect to tumor growth and survival times: 5-FU HAI (group I), 5-FU + DSM HAI (group II), PEG-5-FU HAI (group III), PEG-5-FU + DSM HAI (group IV), NaCl HAI (group V), 5-FU i.v. (group VI), and PEG-5-FU i.v. (group VII).
  
  
  RESULTS
  Seven and 14 days after treatment in groups III and IV, only group IV had significantly inhibited tumor growth on day 21 compared to the groups treated intravenously. On day 28, none of the animals from the intravenously treated groups were still alive compared to a significantly longer survival time of 6 and 8 weeks in groups III and IV.
  
  
  CONCLUSIONS
  Locoregional therapy with 5-fluorouracil encapsulated in PEGylated liposomes may further improve the treatment success with longer-lasting tumor regression and prolonged survival times.
authors.affiliation: Department of General, Vascular and Thoracic Surgery, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Pohlen
authors.forename: Heinz J
authors.initials: HJ
authors.lastname: Buhr
authors.forename: Gerd
authors.initials: G
authors.lastname: Berger
authors.forename: Jörg-Peter
authors.initials: JP
authors.lastname: Ritz
authors.forename: Christoph
authors.initials: C
authors.lastname: Holmer
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D005472:Fluorouracil / Q000008:administration & dosage*; D006499:Hepatic Artery; D007261:Infusions, Intra-Arterial; D008081:Liposomes; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage; D051381:Rats; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000964:Antimetabolites, Antineoplastic; D008081:Liposomes; D011092:Polyethylene Glycols; D005472:Fluorouracil