title: Recent advances in X-chromosome inactivation.
abstract: X-chromosome inactivation is a paradigmatic epigenetic phenomenon that results in the mitotically heritable transcriptional inactivation of one X-chromosome in female mammals, thereby equalizing X-linked gene dosage between the sexes. The epigenetic factors and mechanisms that execute X-inactivation overlap with those that regulate embryonic development and disease progression, thus offering a window into the epigenetic processes that regulate development and disease. Here I summarize some recent developments as well as open questions in X-inactivation research.
authors.affiliation: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109-5618, USA. skalantr@gmail.com
authors.forename: Sundeep
authors.initials: S
authors.lastname: Kalantry
mesh_terms: D000818:Animals; D041321:Chromosomes, Human, X; D004622:Embryo, Mammalian / Q000502:physiology*; D047108:Embryonic Development / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000378:metabolism; D014960:X Chromosome; D049951:X Chromosome Inactivation
chemical_list: D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C077885:XIST non-coding RNA