title: Estimation of serum malondialdehyde in oral cancer and precancer and its association with healthy individuals, gender, alcohol, and tobacco abuse.
abstract: BACKGROUND
  Tobacco and alcohol induces generation of free radicals and reactive oxygen species, which are responsible for high rate of lipid peroxidation. Malondialdehyde is the most widely used marker of lipid peroxidation. The aim of the study was to estimate serum malondialdehyde level in oral precancer, oral cancer, and normal individuals.
  
  
  METHODS
  In this study serum malondialdehyde was measured according to the method of Ohkawa et al in 30 normal individuals and 30 patients each with histopathologically diagnosed oral precancer, and oral cancer.
  
  
  RESULTS
  The mean serum malondialdehyde level in the control group was found to be 5.107 ± 2.32 ηmol/ml, whereas it was 9.33 ± 4.89 ηmol/ml and 14.34 ± 1.43 ηmol/ml in oral precancer and oral cancer, respectively. There was statistically significant increase in serum malondialdehyde levels in the oral precancer and oral cancer patients compared with the control group.
  
  
  CONCLUSIONS
  Increased serum malondialdehyde in oral cancer and oral precancer would serve as a valuable marker for both preventive and clinical intervention, and may deserve further investigation for the early diagnosis, treatment, and prognosis.
authors.affiliation: Department of Oral Medicine and Radiology, Peoples Dental Academy, Bhopal, Madhya Pradesh, India. drchole@rediffmail.com
authors.forename: Revant H
authors.initials: RH
authors.lastname: Chole
authors.forename: Ranjitkumar N
authors.initials: RN
authors.lastname: Patil
authors.forename: Anjan
authors.initials: A
authors.lastname: Basak
authors.forename: Kamlesh
authors.initials: K
authors.lastname: Palandurkar
authors.forename: Rahul
authors.initials: R
authors.lastname: Bhowate
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood*; D011230:Precancerous Conditions / Q000097:blood*; D014029:Tobacco Use Disorder
chemical_list: D008315:Malondialdehyde