title: Anti-HIV activity of Indian medicinal plants.
abstract: Acquired immunodeficiency syndrome patients face great socio-economic difficulties in obtaining treatment. There is an urgent need for new, safe, and cheap anti-HIV agents. Traditional medicinal plants are a valuable source of novel anti-HIV agents and may offer alternatives to expensive medicines in future. Various medicinal plants or plant-derived natural products have shown strong anti-HIV activity and are under various stages of clinical development in different parts of the world. The present study was directed towards assessment of anti-HIV activity of various extracts prepared from Indian medicinal plants. The plants were chosen on the basis of similarity of chemical constituents with reported anti-HIV compounds or on the basis of their traditional usage as immunomodulators. Different extracts were prepared by Soxhlet extraction and liquid-liquid partitioning. Ninety-two extracts were prepared from 23 plants. Anti-HIV activity was measured in a human CD4+ T-cell line, CEM-GFP cells infected with HIV-1NL4.3. Nine extracts of 8 different plants significantly reduced viral production in CEM-GFP cells infected with HIV-1NL4.3. Aegle marmelos, Argemone mexicana, Asparagus racemosus, Coleus forskohlii, and Rubia cordifolia demonstrated promising anti-HIV potential and were investigated for their active principles.
authors.forename: Sudeep
authors.initials: S
authors.lastname: Sabde
authors.forename: Hardik S
authors.initials: HS
authors.lastname: Bodiwala
authors.forename: Aniket
authors.initials: A
authors.lastname: Karmase
authors.forename: Preeti J
authors.initials: PJ
authors.lastname: Deshpande
authors.forename: Amandeep
authors.initials: A
authors.lastname: Kaur
authors.forename: Nafees
authors.initials: N
authors.lastname: Ahmed
authors.forename: Siddheshwar K
authors.initials: SK
authors.lastname: Chauthe
authors.forename: Keyur G
authors.initials: KG
authors.lastname: Brahmbhatt
authors.forename: Rasika U
authors.initials: RU
authors.lastname: Phadke
authors.forename: Debashis
authors.initials: D
authors.lastname: Mitra
authors.forename: Kamlesh Kumar
authors.initials: KK
authors.lastname: Bhutani
authors.forename: Inder Pal
authors.initials: IP
authors.lastname: Singh
mesh_terms: D045471:Aegle / Q000737:chemistry; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D031674:Argemone / Q000737:chemistry; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000821:virology; D002460:Cell Line; D045744:Cell Line, Tumor; D031330:Coleus / Q000737:chemistry; D006678:HIV / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D045470:Rubia / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D010936:Plant Extracts