title: A highly selective pyrophosphate sensor based on ESIPT turn-on in water.
abstract: Pyrophosphate (PPi) is a biologically important target. A binuclear system 3•2Zn is found to selectively recognize PPi, leading to a ratiometric fluorescent sensor at pH 7.4 in water. The binding event triggered a large fluorescence response (∼100 nm bathochromic shift) by turning on the excited state intramolecular proton transfer (ESIPT). Detection of PPi released from a PCR experiment indicated that this new probe could be a useful tool in bioanalytical applications.
authors.affiliation: Department of Chemistry and Maurice Morton Institute of Polymer Science, The University of Akron, Akron, Ohio 44325, United States.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Xing
authors.forename: Yi
authors.initials: Y
authors.lastname: Pang
mesh_terms: D011756:Diphosphates / Q000032:analysis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D011522:Protons; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000032:analysis / Q000737:chemistry
chemical_list: D011756:Diphosphates; D005456:Fluorescent Dyes; D011522:Protons; D014867:Water; D015032:Zinc