title: Split genes: another surprise from Giardia.
abstract: Some genes in the candidate early-branching eukaryote Giardia lamblia occur in separate pieces, transcribed from non-contiguous chromosomal locations. The pre-mRNAs from the separate pieces apparently find each other by regions of complementarity and are subsequently spliced together by the spliceosome. Could genes in pieces, transcribed into separate pre-mRNAs, have been an early feature of spliceosomal evolution?
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. Tom.Blumenthal@Colorado.EDU
authors.forename: Thomas
authors.initials: T
authors.lastname: Blumenthal
mesh_terms: D016054:DNA, Protozoan / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology; D016829:Giardia lamblia / Q000235:genetics*; D019154:Protein Splicing; D015800:Protozoan Proteins; D022821:RNA Splice Sites; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics; D016053:RNA, Protozoan / Q000235:genetics; D017381:Spliceosomes / Q000378:metabolism
chemical_list: D016054:DNA, Protozoan; D015800:Protozoan Proteins; D022821:RNA Splice Sites; D012333:RNA, Messenger; D016053:RNA, Protozoan