title: Representational difference analysis.
abstract: Successful pathogens have evolved a variety of specific gene products that facilitate their survival and growth within the host, as well as mechanisms to regulate expression of these virulence-associated genes in response to their environment. In comparison with commensals, the pathogenic phenotype can thus be seen as a consequence of both differences in gene content and gene expression. Not surprisingly, identification of these differences is a frequent goal in modern biomedical research, and as a result, a variety of differential screening methods have been developed over the last few years (1,2).
authors.affiliation: Trafford Centre for Medical Research, University of Sussex, Brighton, UK.
authors.forename: L D
authors.initials: LD
authors.lastname: Bowler
authors.forename: A
authors.initials: A
authors.lastname: Bart
authors.forename: A
authors.initials: A
authors.lastname: van der Ende