title: A simple functional marker to predict the need for prolonged mechanical ventilation in patients with Guillain-Barré syndrome.
abstract: BACKGROUND
  Patients suffering from Guillain-Barré syndrome (GBS) may frequently develop an acute respiratory failure and need ventilatory support. Immune therapy using plasma exchange or immunoglobulins has modified the natural course of the disease and by decreasing the length of the plateau phase, may induce a rapid improvement in ventilatory function. However a substantial proportion of patients still require prolonged mechanical ventilation (MV) and tracheotomy. The present study was designed to search for simple functional markers that could predict the need for prolonged MV just after completion of immune therapy.
  
  
  METHODS
  We analyzed the data collected in a cohort of patients with GBS admitted to the intensive care unit (ICU) of our university hospital between 1996 and 2009. Demographic, clinical, biological and electrophysiologic data, results of sequential spirometry, and times of endotracheal intubation, tracheotomy, and MV weaning were prospectively collected for all patients. Sequential daily neurological testing used standardized data collection by the same investigators all along the study period. Results were compared by single and multiple regression analysis at admission to ICU and at the end of immune therapy, according to the need and duration of MV (≤ or > 15 days).
  
  
  RESULTS
  Sixty-one patients with severe GBS were studied. Sixty-six percent required MV (median length: 24 days). The lack of foot flexion ability at ICU admission and at the end of immunotherapy was significantly associated with MV length > 15 days (positive predictive value: 82%; odds ratio: 5.4 [1.2 - 23.8] and 82%; 6.4 [1.4 - 28.8], respectively). The association of a sciatic nerve motor conduction block with the lack of foot flexion at the end of immunotherapy was associated with prolonged MV with a 100% positive predictive value.
  
  
  CONCLUSIONS
  In patients admitted to ICU with Guillain-Barré syndrome and acute respiratory failure, the lack of foot flexion ability at the end of immune therapy predicts a prolonged duration of MV. Combined with a sciatic motor conduction block, it may be a strong argument to perform an early tracheotomy.
authors.affiliation: Département Universitaire de Réanimation, Université de Lille 2, et Service de Réanimation Polyvalente, Hôpital Roger Salengro CHRU de Lille, Rue Emile Laine 59037, Lille, France. francois.fourrier@chru-lille.fr
authors.forename: François
authors.initials: F
authors.lastname: Fourrier
authors.forename: Laurent
authors.initials: L
authors.lastname: Robriquet
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Hurtevent
authors.forename: Shirley
authors.initials: S
authors.lastname: Spagnolo
mesh_terms: D000328:Adult; D000368:Aged; D003422:Critical Care / Q000379:methods*; D005260:Female; D005528:Foot / Q000503:physiopathology*; D020275:Guillain-Barre Syndrome / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009141:Musculoskeletal System / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000706:statistics & numerical data*; D013997:Time Factors