title: 5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation.
abstract: Amygdala reactivity is a heritable trait, potentiated in affective disorders and associated with both the 5-HTTLPR and the COMTval158met polymorphism. Fifty-four healthy volunteers selected a priori based on gender and 5-HTTLPR/rs25531 and COMTval158met genotypes performed a passive viewing task of angry facial expressions using fMRI. Amygdala reactivity and habituation were investigated using the a priori anatomical region of interest (ROI) approach. Furthermore, salivary cortisol and skin conductance responses were recorded. We observed an effect of 5-HTTLPR on right amygdala reactivity (s-carrier>l/l) and COMTval158met on left amygdala reactivity (met/met>val-carrier). We provide preliminary evidence that different amygdala habituation curves may partly underlie the differences between 5-HTTLPR and not COMT genotype groups. Further, exploratory analyses find no evidence for additive or interaction effects. Our results support that 5-HTTLPR s-carriers and COMT met/met carriers may be more sensitive to the detection of biologically and socially relevant information and suggest a mechanism behind this for the 5-HTTLPR.
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. t.lonsdorf@uke.de
authors.forename: Tina B
authors.initials: TB
authors.lastname: Lonsdorf
authors.forename: Armita
authors.initials: A
authors.lastname: Golkar
authors.forename: Kara M
authors.initials: KM
authors.lastname: Lindstöm
authors.forename: Peter
authors.initials: P
authors.lastname: Fransson
authors.forename: Martin
authors.initials: M
authors.lastname: Schalling
authors.forename: Arne
authors.initials: A
authors.lastname: Ohman
authors.forename: Martin
authors.initials: M
authors.lastname: Ingvar
mesh_terms: D000328:Adult; D000679:Amygdala / Q000098:blood supply / Q000502:physiology*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005145:Face; D005260:Female; D005712:Galvanic Skin Response; D005838:Genotype; D006185:Habituation, Psychophysiologic / Q000235:genetics*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008715:Methionine / Q000235:genetics; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012463:Saliva / Q000737:chemistry; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D014633:Valine / Q000235:genetics; D055815:Young Adult
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine; D010100:Oxygen; D006854:Hydrocortisone