title: Clinical and histological presentation of Helicobacter pylori and gluten related gastroenteropathy.
abstract: Celiac disease has been reported to be associated with gastric abnormalities. The aim of this study was to assess the relationship between the prevalence of celiac disease and Helicobacter pylori infection in an Iranian population of 250 patients.
  
  
  
  Biopsies were taken from the gastric antrum and duodenum. Morphology and histology were evaluated using the updated Sydney system and modified Marsh criteria, respectively. To simplify the interpretation of gastric lesions we classified gastritis in macroscopic and microscopic stages. Serology for anti-tissue transglutaminase antibody was performed to determine the presence of celiac disease.
  
  
  
  Among 250 patients, 232 (93%) had histological evidence of Helicobacter pylori infection. Histological abnormalities (Marsh I to IIIc) were present in 24 (10%). Of 24 patients, 20 (83%) with histological abnormalities were infected with Helicobacter pylori. Of 250 patients, 25 (10%) had a positive anti-tissue transglutaminase antibody. Of 25 anti-tissue transglutaminase antibody positive patients, 9 (3.6%) had microscopic and macroscopic enteritis (Marsh I to IIIc).
  
  
  
  Clinical presentation of celiac disease was not distinguishable from cases infected with Helicobacter pylori. Histology, even in patients with positive serology, was non-specific and unhelpful. We found a high prevalence of Helicobacter pylori infection and chronic gastritis, but neither was associated with celiac disease, in agreement with studies in Western populations.
authors.affiliation: Research Institute of Gastroenterology and Liver Disease, Shahid Beheshti University, M.C., Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rostami Nejad
authors.forename: Kamran
authors.initials: K
authors.lastname: Rostami
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: Reza
authors.initials: R
authors.lastname: Mashayekhi
authors.forename: Mahsa
authors.initials: M
authors.lastname: Molaei
authors.forename: Hossein
authors.initials: H
authors.lastname: Dabiri
authors.forename: David
authors.initials: D
authors.lastname: Al Dulaimi
authors.forename: Dariush
authors.initials: D
authors.lastname: Mirsattari
authors.forename: Homayoun
authors.initials: H
authors.lastname: Zojaji
authors.forename: Mohsen
authors.initials: M
authors.lastname: Norouzinia
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Zali
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood; D001706:Biopsy; D002446:Celiac Disease / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D016009:Chi-Square Distribution; D005260:Female; D005756:Gastritis / Q000150:complications* / Q000473:pathology; D005983:Glutens / Q000276:immunology; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011706:Pyloric Antrum / Q000473:pathology; D012720:Severity of Illness Index; D011503:Transglutaminases / Q000276:immunology; D055815:Young Adult
chemical_list: D000906:Antibodies; D005983:Glutens; D011503:Transglutaminases