title: A guide towards pre-pregnancy management of defective implantation and placentation.
abstract: Pregnancy complications such as pre-eclampsia, placental abruption and growth restriction were once thought to represent end-of-pregnancy issues. Currently, the cause of such complications are being increasingly recognised as defective implantation and placentation. The molecular mechanisms responsible for normal and abnormal implantation are an area of active investigation. Screening tests, such as Doppler ultrasound of the maternal uterine arteries and evaluation of markers in the maternal serum, are being assessed to determine if such tests might allow for better recognition and, perhaps, prevention of many pregnancy complications related to abnormal placentation. Many techniques during pregnancy have been used to prevent pregnancy complications such as pre-eclampsia. Most have been unsuccessful. Ultimately, the solution may reside in pre-pregnancy approaches to improve implantation and placentation. Such approaches are actively being investigated and have promise.
authors.affiliation: Department of Obstetrics and Gynecology, Tufts Medical Center and Tufts University School of Medicine, 800 Washington Street, Boston, MA 02111, USA.
authors.forename: Adam C
authors.initials: AC
authors.lastname: Urato
authors.forename: Errol R
authors.initials: ER
authors.lastname: Norwitz
mesh_terms: D010064:Embryo Implantation / Q000502:physiology*; D005260:Female; D006801:Humans; D010922:Placenta Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control; D010929:Placentation / Q000502:physiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000503:physiopathology* / Q000517:prevention & control*