title: Hypertrophic obstructive cardiomyopathy, bleeding history, and acquired von Willebrand syndrome: response to septal myectomy.
abstract: Bleeding with severe aortic stenosis is linked to acquired von Willebrand syndrome and loss of high-molecular-weight multimers of von Willebrand factor. Valve replacement resolves bleeding tendency and loss of high-molecular-weight multimers. We report outcomes in 5 patients with symptomatic obstructive hypertrophic cardiomyopathy and spontaneous gastrointestinal, mucosal, or excessive postsurgical bleeding in whom acquired von Willebrand syndrome was documented. All 5 patients underwent surgical septal myectomy with resolution of acquired von Willebrand syndrome.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL 32224, USA. blackshear.joseph@mayo.edu
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Blackshear
authors.forename: Hartzell V
authors.initials: HV
authors.lastname: Schaff
authors.forename: Steve R
authors.initials: SR
authors.lastname: Ommen
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.forename: William L
authors.initials: WL
authors.lastname: Nichols
mesh_terms: D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000601:surgery*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology* / Q000628:therapy; D006346:Heart Septum / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D016896:Treatment Outcome; D014842:von Willebrand Diseases / Q000209:etiology* / Q000601:surgery*