title: Iodine deficiency in northern Paris area: impact on fetal thyroid mensuration.
abstract: BACKGROUND
  Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation.
  
  
  METHODS
  110 patients underwent several determinations of urinary iodine excretion (UIE) and of serum FT4, FT3, and TSH. Fetal thyroid gland size was assessed using ultrasonography.
  
  
  RESULTS
  We found evidence of widespread iodine deficiency (mean UIE, 49.8 µg/L [standard deviation, 2.11]). Iodine deficiency did not correlate significantly with maternal thyroid parameters but showed a significant negative correlation with fetal thyroid gland size (rho = 0.25, P = 0.02).
  
  
  CONCLUSIONS
  Iodine deficiency during pregnancy is still a problem in our geographical area and affects the fetal thyroid gland. Clinical Trials.gov NCT00162539.
authors.affiliation: Université Paris VII, AP-HP, GHU Nord, Hôpital Beaujon, Service de Gynécologie Obstétrique, Clichy, France. dluton@free.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Luton
authors.forename: Corinne
authors.initials: C
authors.lastname: Alberti
authors.forename: Edith
authors.initials: E
authors.lastname: Vuillard
authors.forename: Guillaume
authors.initials: G
authors.lastname: Ducarme
authors.forename: Jean François
authors.initials: JF
authors.lastname: Oury
authors.forename: Jean
authors.initials: J
authors.lastname: Guibourdenche
mesh_terms: D000465:Algorithms; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D005865:Gestational Age; D006801:Humans; D007455:Iodine / Q000172:deficiency* / Q000627:therapeutic use; D009929:Organ Size; D010297:Paris / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000652:urine; D013959:Thyroid Diseases / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000652:urine; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000196:embryology*; D016216:Ultrasonography, Prenatal
chemical_list: D007455:Iodine