title: [Reference values for thyroid hormones in the population of pregnant women in Jaen (Spain)].
abstract: OBJECTIVE
  To evaluate thyroid function in the three trimesters of pregnancy in healthy women taking iodine and to define the reference ranges of normality in this population.
  
  
  METHODS
  Descriptive study of pregnant women to define the ranges of normality of thyroid hormones in this population.
  
  
  METHODS
  Jaen and Osuna (Spain).
  
  
  METHODS
  Healthy pregnant women.
  
  
  METHODS
  Thyroid hormone determination in the three trimesters of pregnancy in healthy women taking iodine supplements.
  
  
  RESULTS
  A total of 429 pregnant women taking iodine supplements to maintain urinary iodine levels within the normal range were included. T4-l levels were between 0.60 and 1.06 in the first trimester, between 0.43 and 0.85 ng/dl in the second and between 0.40 and 0.82 ng/dl in the third. Thyroid stimulating hormone (TSH) reference values were between 0.23 and 4.18μUI/ml in the first trimester, 1.78 and 3.89μUI/ml in the second and 2.01 and 4.30μUI/ml in the third. T3-l values were between 2.33 and 3.84 pg/ml in the first trimester, between 2.04 and 3.51 pg/ml in the second and between 1.99 and 3.46 pg/ml in the third.
  
  
  CONCLUSIONS
  Bearing the 3rd and 97th percentiles in mind, the reference ranges in our population were far below those recommended by our reference laboratory. In view of these results, these values should be redefined to avoid incorrect diagnoses of hyperthyroxinemia in healthy pregnant women.
authors.affiliation: UGC de Análisis Clínicos y Servicio de Radiología, Complejo Hospitalario de Jaén, Jaén, España. santiago11@ono.com
authors.forename: Piedad
authors.initials: P
authors.lastname: Santiago
authors.forename: María
authors.initials: M
authors.lastname: Berrio
authors.forename: Pablo
authors.initials: P
authors.lastname: Olmedo
authors.forename: Inés
authors.initials: I
authors.lastname: Velasco
authors.forename: Baltasar
authors.initials: B
authors.lastname: Sánchez
authors.forename: Eduardo
authors.initials: E
authors.lastname: García
authors.forename: Julia
authors.initials: J
authors.lastname: Martínez
authors.forename: Federico
authors.initials: F
authors.lastname: Soriguer
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000652:urine; D005260:Female; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood; D007455:Iodine / Q000652:urine; D011247:Pregnancy / Q000097:blood*; D011264:Pregnancy Trimesters; D011989:Receptors, Thyrotropin / Q000276:immunology; D012016:Reference Values; D013030:Spain; D013954:Thyroglobulin / Q000097:blood; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D018997:Chorionic Gonadotropin, beta Subunit, Human; D018828:Immunoglobulins, Thyroid-Stimulating; D011989:Receptors, Thyrotropin; C056626:thyroid microsomal antibodies; C094372:thyrotropin-binding inhibitory immunoglobulin; D014284:Triiodothyronine; D013972:Thyrotropin; D013954:Thyroglobulin; D007455:Iodine; D013974:Thyroxine