title: Accumulation of p53 determined by immunohistochemistry as a prognostic marker in node negative breast cancer; analysis according to St Gallen consensus and intrinsic subtypes.
abstract: BACKGROUND
  This study evaluated the prognostic impact of p53 accumulation by immunohistochemistry (IHC) in lymph node-negative breast cancer (LNN-BC), and in subgroups of St Gallen consensus and intrinsic subtypes.
  
  
  METHODS
  A total 845 with a pathologic diagnosis of LNN-BC patients that underwent surgery at the National Cancer Center, Korea between 2001 and 2005 were retrospectively reviewed.
  
  
  RESULTS
  The median age was 48 years (range: 25-85) and median follow-up period was 66.0 months (range: 9-101). Univariate analysis determined that tumor size, estrogen receptor (ER), progesterone receptor (PgR), p53, and Ki-67 were significant for disease free survival (DFS). Of these factors, PgR negativity (HR 3.57; 95% CI 1.26-10.09; P = 0.01) and p53 positivity (HR 3.17; 95% CI 1.51-6.65; P = 0.002) were independent prognostic factors in multivariate analysis. In the subanalysis for 4 intrinsic subtypes (luminal A, luminal B, HER2-overexpression, and triple-negative subtypes) and risk groups by St Gallen consensus, there were significant differences of DFS rates by p53 (5-year DFS rate, luminal A; 97.2% for p53 (-) vs 93.8% for p53 (+); P = 0.03, triple-negative subgroups; 94.1% vs 78.7%; P = 0.002, intermediate-risk group; 96.5% vs 90.7%; P = 0.003).
  
  
  CONCLUSIONS
  P53 has prognostic power in LNN-BC, and gives the additional prognostic information for intrinsic subtypes and St Gallen consensus.
authors.affiliation: Center for Breast Cancer, National Cancer Center, Goyang, Republic of Korea.
authors.forename: So-Youn
authors.initials: SY
authors.lastname: Jung
authors.forename: Junsoo
authors.initials: J
authors.lastname: Jeong
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Shin
authors.forename: Youngmee
authors.initials: Y
authors.lastname: Kwon
authors.forename: Eun-A
authors.initials: EA
authors.lastname: Kim
authors.forename: Kyoung Lan
authors.initials: KL
authors.lastname: Ko
authors.forename: Kyung Hwan
authors.initials: KH
authors.lastname: Shin
authors.forename: Jungsil
authors.initials: J
authors.lastname: Ro
authors.forename: Keun Seok
authors.initials: KS
authors.lastname: Lee
authors.forename: In Hae
authors.initials: IH
authors.lastname: Park
authors.forename: Seeyoun
authors.initials: S
authors.lastname: Lee
authors.forename: Seok Won
authors.initials: SW
authors.lastname: Kim
authors.forename: Han-Sung
authors.initials: HS
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000235:genetics*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor