title: Sp1 collagen I A1 polymorphism in women with stress urinary incontinence.
abstract: OBJECTIVE
  Stress urinary incontinence (SUI) is in part attributed to qualitative and quantitative changes in connective tissue of the urogenital tract. We examined the association of collagen type I a1 (COLIA 1) Sp1 polymorphism with the risk of SUI.
  
  
  METHODS
  Forty-five postmenopausal women suffering from urodynamically verified SUI (study group) were compared to 45 healthy volunteers (control). DNA was extracted from peripheral blood. The genotyping concerning the type 1 a1 collagen gene Sp1 polymorphism was performed with polymerase chain reaction.
  
  
  RESULTS
  The polymorphic T allele was overrepresented in the SUI patients (63.2% versus 36.8%, p = 0.016). Odds ratio for SUI in women harboring the T allele was 2.19 (95% CI 1.149-4.176) compared to women with the wild-type genotype.
  
  
  CONCLUSIONS
  The COLIA1 Sp1 polymorphism is associated with increased prevalence of stress urinary incontinence in postmenopausal women.
authors.affiliation: Second Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece.
authors.forename: Dimos
authors.initials: D
authors.lastname: Sioutis
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Economou
authors.forename: Irene
authors.initials: I
authors.lastname: Lambrinoudaki
authors.forename: Vasilios
authors.initials: V
authors.lastname: Tsamadias
authors.forename: Maria
authors.initials: M
authors.lastname: Creatsa
authors.forename: Angelos
authors.initials: A
authors.lastname: Liapis
mesh_terms: D000368:Aged; D000483:Alleles; D024042:Collagen Type I / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017698:Postmenopause; D015995:Prevalence; D014550:Urinary Incontinence, Stress / Q000453:epidemiology / Q000235:genetics*
chemical_list: D024042:Collagen Type I