title: Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes.
abstract: OBJECTIVE
  To assess the impact of continuous glucose monitoring on hypoglycemia in people with type 1 diabetes.
  
  
  METHODS
  In this randomized, controlled, multicenter study, 120 children and adults on intensive therapy for type 1 diabetes and a screening level of glycated hemoglobin A(1c) (HbA(1c)) <7.5% were randomly assigned to a control group performing conventional home monitoring with a blood glucose meter and wearing a masked continuous glucose monitor every second week for five days or to a group with real-time continuous glucose monitoring. The primary outcome was the time spent in hypoglycemia (interstitial glucose concentration <63 mg/dL) over a period of 26 weeks. Analysis was by intention to treat for all randomized patients.
  
  
  RESULTS
  The time per day spent in hypoglycemia was significantly shorter in the continuous monitoring group than in the control group (mean ± SD 0.48 ± 0.57 and 0.97 ± 1.55 h/day, respectively; ratio of means 0.49; 95% CI 0.26-0.76; P = 0.03). HbA(1c) at 26 weeks was lower in the continuous monitoring group than in the control group (difference -0.27%; 95% CI -0.47 to -0.07; P = 0.008). Time spent in 70 to 180 mg/dL normoglycemia was significantly longer in the continuous glucose monitoring group compared with the control group (mean hours per day, 17.6 vs. 16.0, P = 0.009).
  
  
  CONCLUSIONS
  Continuous glucose monitoring was associated with reduced time spent in hypoglycemia and a concomitant decrease in HbA(1c) in children and adults with type 1 diabetes.
authors.affiliation: Department of Pediatric Endocrinology, Diabetes and Metabolism, Faculty of Medicine, University Medical Centre-University Children’s Hospital, University of Ljubljana, Ljubljana, Slovenia. tadej.battelino@mf.uni-lj.si
authors.forename: Tadej
authors.initials: T
authors.lastname: Battelino
authors.forename: Moshe
authors.initials: M
authors.lastname: Phillip
authors.forename: Natasa
authors.initials: N
authors.lastname: Bratina
authors.forename: Revital
authors.initials: R
authors.lastname: Nimri
authors.forename: Per
authors.initials: P
authors.lastname: Oskarsson
authors.forename: Jan
authors.initials: J
authors.lastname: Bolinder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015190:Blood Glucose Self-Monitoring; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin