title: Trehalose: current use and future applications.
abstract: Trehalose, a disaccharide of glucose, has been reported to accumulate in many organisms that can withstand extended periods of inanimation. Since this discovery, the properties of trehalose have been examined extensively to understand its role and abundance in nature. The unique features of this sugar became clearer with each new finding which demonstrated its ability to sustain and preserve a wide array of biological molecules. Trehalose has been used in a variety of research applications and is contained in several commercially available therapeutic products, including Herceptin®, Avastin®, Lucentis®, and Advate®. Currently, there is a growing interest in the use of trehalose in solid dosage formulations, most notably in quick-dissolving tablets. Furthermore, trehalose has found its use in several food and cosmetic products, and new applications capitalizing on its unique properties are being developed and implemented in everyday-use products. As trehalose is an approved ingredient in all major markets, there is no significant barrier to its use. Extensive work with trehalose has been conducted in the three major industries, however with little overlap. Further understanding of the role of trehalose in the various applications may lead to an increase in the number of trehalose-containing products.
authors.affiliation: Aridis Pharmaceuticals, San Jose, California 95138, USA. ohtakes@aridispharma.com
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohtake
authors.forename: Y John
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D003358:Cosmetics / Q000737:chemistry; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010602:Pharmacopoeias as Topic; D013678:Technology, Pharmaceutical / Q000639:trends*; D014199:Trehalose / Q000737:chemistry*
chemical_list: D003358:Cosmetics; D005079:Excipients; D004364:Pharmaceutical Preparations; D014199:Trehalose