title: The pharmacological management of intrahepatic cholestasis of pregnancy.
abstract: Intrahepatic cholestasis of pregnancy is the most common liver disease occurring in the second half of pregnancy, characterized by pruritus and elevated serum bile acids often coupled to abnormal liver tests. Maternal prognosis is favourable with a complete symptom resolution after delivery, while preterm deliveries, fetal respiratory distress and stillbirths may occur. The goal of the pharmacological treatment of the disease is to improve maternal symptoms and biochemical alterations and, most importantly, to reduce fetal adverse events.The present manuscript will review the current knowledge on the pharmacological treatment of intrahepatic cholestasis of pregnancy.
authors.affiliation: Department of Clinical Medicine, Gastroenterology Unit, St. Orsola-Malpighi Hospitali, University of Bologna, Italy. francesco.azzaroli@unibo.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Azzaroli
authors.forename: Laura
authors.initials: L
authors.lastname: Turco
authors.forename: Andrea
authors.initials: A
authors.lastname: Lisotti
authors.forename: Claudio
authors.initials: C
authors.lastname: Calvanese
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mazzella
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood; D002780:Cholestasis, Intrahepatic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000503:physiopathology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011379:Prognosis; D011537:Pruritus / Q000209:etiology
chemical_list: D001647:Bile Acids and Salts