title: Aromatic compounds from the liverwort Conocephalum japonicum.
abstract: Two undescribed dimeric ArC2 derivatives, cis- and trans-1,2-bis(3,4-dimethoxyphenyl)cyclobutane (1 and 2), one new monoterpenes esters, 2alpha,5beta-dihydroxybornane-2-cis-cinnamate (3), along with eight known compounds, 2alpha,5beta-dihydroxybornane-2-trans-cinnamate (4), perrottetin E (5), isoriccardin C (6), marchantin A (7), marchantin E (8), marchantin C (9), and isomarchantin C (10) were isolated from the liverwort Conocephalum japonicum. All the structures were established by extensive spectroscopic analysis. The isolated compounds 3-10 were evaluated for their cytotoxicity against the human KB cell line with IC50 values ranging from 16.5 to 50.2 microM.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Dong-Xiao
authors.initials: DX
authors.lastname: Guo
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Wang
authors.forename: Li-Ning
authors.initials: LN
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Ji
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001632:Bibenzyls / Q000302:isolation & purification; D002396:Catechols / Q000302:isolation & purification; D004988:Ethers, Cyclic / Q000302:isolation & purification; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D010647:Phenyl Ethers / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D002396:Catechols; D004988:Ethers, Cyclic; D010647:Phenyl Ethers; C459128:isoriccardin C; C459129:marchantin C