title: [Interaction between dietary intake and GSTM1 and GSTT1 polymorphisms in head and neck cancer risk: a case-control study in São Paulo, Brazil].
abstract: A hospital-based case-control study was conducted to investigate the potential interaction between dietary factors and polymorphisms in phase II metabolic enzymes GSTM1 and GSTT1, associated with head and neck cancer risk. The study included 103 histologically confirmed incident cases and 101 controls. Food intake was estimated with a validated food frequency questionnaire. The gene polymorphisms were evaluated by PCR. Increased risk was observed in the highest tertile of beef consumption in the presence of the GSTM1 (OR = 10.79; 95%CI: 2.17-53.64) and GSTT1 null alleles (OR = 3.41; 95%CI: 0.43-27.21). Assessment of dietary intake considering the ratio between animal product and vegetable consumption showed OR = 2.35 (95%CI: 0.27-19.85) in the intermediate tertile and OR = 3.36 (95%CI: 0.41-27.03) in the highest tertile. The results suggest a possible interaction between meat intake and GSTM1/GSTT1 polymorphisms in modulating the risk of head and neck cancer, influenced by vegetable consumption.
authors.affiliation: Departamento de Nutrição, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo 715, São Paulo, SP, Brazil. marchioni@usp.br
authors.forename: Dirce Maria Lobo
authors.initials: DM
authors.lastname: Marchioni
authors.forename: Gilka Jorge Figaro
authors.initials: GJ
authors.lastname: Gattás
authors.forename: Otavio A
authors.initials: OA
authors.lastname: Curioni
authors.forename: Marcos Brasilino de
authors.initials: MB
authors.lastname: Carvalho
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D016022:Case-Control Studies; D004032:Diet; D004034:Diet Surveys; D005247:Feeding Behavior; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000209:etiology* / Q000235:genetics; D006801:Humans; D008297:Male; D008460:Meat; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014675:Vegetables
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1