title: Intracellular signal transduction as a factor in the development of "smart" biomaterials for bone tissue engineering.
abstract: Signal transduction involves studying the intracellular mechanisms that govern cellular responses to external stimuli such as hormones, cytokines, and also cell adhesion to biomaterials surfaces. Several events have been shown to be responsible for cellular adhesion and adaptation onto different surfaces. For instance, cytoskeletal rearrangements during cell adhesion require the recruitment of specific protein tyrosine kinases into focal adhesion structures that promote transient focal adhesion kinase and Src phosphorylations, initially modulating cell behavior. In addition, the phosphorylation of tyrosine (Y) residues have been generally accepted as a critical regulator of a wide range of cell-related processes, including cell proliferation, migration, differentiation, survival signalling, and energy metabolism. The understanding of the signaling involved on the mechanisms of osteoblast adhesion, proliferation, and differentiation on implant surfaces is fundamental for the successful design of novel "smart" materials, potentially decreasing the repair time, thereby allowing for faster patient rehabilitation.
authors.affiliation: Fluminense Federal University, Cell Therapy Center, Avenida Marquês de Paraná, 303, Niterói, BR 24030-215, Brazil. wzambuzzi@gmail.com
authors.forename: Willian F
authors.initials: WF
authors.lastname: Zambuzzi
authors.forename: Paulo G
authors.initials: PG
authors.lastname: Coelho
authors.forename: Gutemberg G
authors.initials: GG
authors.lastname: Alves
authors.forename: José M
authors.initials: JM
authors.lastname: Granjeiro
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D006801:Humans; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism; D019736:Prostheses and Implants; D015398:Signal Transduction; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials