title: Stuve-Wiedemann syndrome: a skeletal dysplasia characterized by bowed long bones.
abstract: OBJECTIVE
  To describe the prenatal sonographic features of Stuve-Wiedemann syndrome (SWS).
  
  
  METHODS
  A retrospective review of all cases of confirmed SWS during an 8-year period was conducted. Clinical and historical data and outcome of the pregnancies were noted. Fetal biometry, skeletal survey, amniotic fluid volume and associated anomalies were recorded. A sonographic algorithm was proposed to distinguish SWS from other bent bone disorders.
  
  
  RESULTS
  In total, there were 10 cases, six of which were diagnosed prenatally. The main prenatal features of SWS were mild-to-moderate micromelia and bowing of the lower limb bones, affecting the tibia more than the femur. There was relative sparing of fibula and upper limb bones, with normal scapulae and clavicles. Camptodactyly was the main associated anomaly. All fetuses developed growth restriction in the late second trimester with oligohydramnios in half of the cases. These features could appear late in pregnancy. Although the thoracic dimensions were normal in the majority of fetuses, respiratory insufficiency, as a result of myotonia, was a leading cause for mortality.
  
  
  CONCLUSIONS
  It is possible to diagnose SWS prenatally. SWS is associated with high mortality during the first year of life, and those who survive have high morbidity.
authors.affiliation: OBYGN/Fetal Medicine Unit, Tawam Hospital, Al Ain, Abu Dhabi, United Arab Emirates.
authors.forename: M A
authors.initials: MA
authors.lastname: Begam
authors.forename: W
authors.initials: W
authors.lastname: Alsafi
authors.forename: G N
authors.initials: GN
authors.lastname: Bekdache
authors.forename: F
authors.initials: F
authors.lastname: Chedid
authors.forename: L
authors.initials: L
authors.lastname: Al-Gazali
authors.forename: H M
authors.initials: HM
authors.lastname: Mirghani
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging* / Q000196:embryology / Q000401:mortality; D000465:Algorithms; D001699:Biometry; D005097:Exostoses, Multiple Hereditary / Q000000981:diagnostic imaging* / Q000196:embryology / Q000401:mortality; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit / Q000235:genetics; D008297:Male; D010009:Osteochondrodysplasias / Q000000981:diagnostic imaging* / Q000196:embryology / Q000401:mortality; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal
chemical_list: C507840:LIFR protein, human; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit