title: [Grading of adults primitive glial neoplasms using arterial spin-labeled perfusion MR imaging].
abstract: OBJECTIVE
  We investigated the relationship between tumor blood-flow measurement based on perfusion-imaging by arterial spin-labeling (ASL) and histopathologic findings in adults' primitive glial tumours.
  
  
  METHODS
  Thus, 40 primitive brain tumors (8 low-grade and 32 high-grade gliomas according to the Sainte-Anne classification) were imaged using pulsed (n=19) or continuous (n=21) ASL. Relative cerebral blood flow (rCBF=tumoral blood flow/normal cerebral blood flow) between high- and low-grade gliomas were compared.
  
  
  RESULTS
  Using pulsed ASL, differences in mean rCBF were observed in high- and low-grade gliomas although no significant (respectively 1.95 and 1.5). Using continuous ASL, mean rCBF were significantly higher for high-grade than for low-grade gliomas (P<0.05). High-grade gliomas could be discriminated using a CBF threshold of 1.18, with a sensitivity of 88%, specificity of 60%, predictive positive value of 88%, and predictive negative value of 60%.
  
  
  CONCLUSIONS
  ASL-based perfusion provides a quantitative, non-invasive alternative to dynamic susceptibility contrast perfusion MR methods for evaluating CBF. ASL is a suitable method for gliomas initial staging and could be useful to identify intermediate tumoral evolution.
authors.affiliation: Service de neuroradiologie, centre hospitalier Sainte-Anne, université Paris Descartes, 1, rue Cabanis, 75014 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Canale
authors.forename: S
authors.initials: S
authors.lastname: Rodrigo
authors.forename: T
authors.initials: T
authors.lastname: Tourdias
authors.forename: C
authors.initials: C
authors.lastname: Mellerio
authors.forename: M
authors.initials: M
authors.lastname: Perrin
authors.forename: R
authors.initials: R
authors.lastname: Souillard
authors.forename: C
authors.initials: C
authors.lastname: Oppenheim
authors.forename: J F
authors.initials: JF
authors.lastname: Meder
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000098:blood supply / Q000473:pathology*; D002560:Cerebrovascular Circulation; D005260:Female; D005910:Glioma / Q000098:blood supply / Q000473:pathology*; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D013113:Spin Labels
chemical_list: D013113:Spin Labels