title: [STAT1 and STAT2 participate in growth inhibition of human hepatoma HepG2 cells induced by phosphatidylethanolamine].
abstract: OBJECTIVE
  To investigate the roles of STAT1 and STAT2 in growth inhibition induced by phosphatidylethanolamine (PE) in human hepatoma HepG2 cells.
  
  
  METHODS
  The growth of HepG2 cells exposed to 0.125, 0.25, 0.5 and 1.0 mmol/L PE was assessed by MTT assay, and the expressions of STAT1 and STAT2 were analyzed using immunocytochemical assay.
  
  
  RESULTS
  PE inhibited the growth of HepG2 cells in a dose-dependent manner and increased the expression of STAT1 and STAT2 in comparison with those in the control group. AG490, an inhibitor of JAKs, partially reversed PE-induced growth inhibition of HepG2 cells.
  
  
  CONCLUSIONS
  STAT1 and STAT2 are involved in the growth inhibition of human hepatoma HepG2 cells induced by PE.
authors.affiliation: Xi an Jiaotong University College of Medicine, Xi an 710061, China.
authors.forename: Li-ying
authors.initials: LY
authors.lastname: Liu
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
authors.forename: Zong-fang
authors.initials: ZF
authors.lastname: Li
authors.forename: Ai-ying
authors.initials: AY
authors.lastname: Wang
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Hu
authors.forename: Lei
authors.initials: L
authors.lastname: Ni
authors.forename: Lin
authors.initials: L
authors.lastname: Yu
authors.forename: Tu-sheng
authors.initials: TS
authors.lastname: Song
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation; D056945:Hep G2 Cells; D006801:Humans; D010714:Phosphatidylethanolamines / Q000494:pharmacology*; D050794:STAT1 Transcription Factor / Q000378:metabolism*; D050795:STAT2 Transcription Factor / Q000378:metabolism*
chemical_list: D010714:Phosphatidylethanolamines; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D050795:STAT2 Transcription Factor; C494084:STAT2 protein, human; C483858:phosphatidylethanolamine