title: Synthesis, biopharmaceutical characterization, antimicrobial and antioxidant activities of 1-(4'-O-β-D-glucopyranosyloxy-2'-hydroxyphenyl)-3-aryl-propane-1,3-diones.
abstract: This research communication is toward the investigation of the antibacterial, antifungal and antioxidant activities of the synthesized compounds 1-(4'-O-β-D-glucopyranosyloxy-2'-hydroxyphenyl)-3-aryl-propane-1,3-diones (5a)-(5h). These compounds have been obtained by the interaction of α-acetobromoglucose with 1-(2',4'-dihydroxyphenyl)-3-aryl-propane-1,3-diones (3a)-(3h) under anhydrous condition and at lower temperature. The structures of these newly synthesized O-β-D-glucopyranosides were established on the basis of chemical, elemental, and spectral analyses. Further, the compounds (5b), (5c), (5d) and (5g) showed potent antibacterial and antifungal activity. A good correlation was obtained between the theoretical predictions of bioavailability using Lipinski's rule-of-five and experimental verification.
authors.affiliation: National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India. javedchemie@gmail.com
authors.forename: Javed
authors.initials: J
authors.lastname: Sheikh
authors.forename: Ali
authors.initials: A
authors.lastname: Parvez
authors.forename: Harjeet
authors.initials: H
authors.lastname: Juneja
authors.forename: Vishwas
authors.initials: V
authors.lastname: Ingle
authors.forename: Zahid
authors.initials: Z
authors.lastname: Chohan
authors.forename: Moulay
authors.initials: M
authors.lastname: Youssoufi
authors.forename: Taibi
authors.initials: T
authors.lastname: Ben Hadda
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D000890:Anti-Infective Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007659:Ketones; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl