title: Mitral regurgitation due to papillary muscle dyssynchrony during trastuzumab treatment.
abstract: Trastuzumab is a monoclonal antibody used for the treatment of metastatic breast carcinoma in women whose tumors overexpress the human epidermal growth factor receptor-2. Although trastuzumab is generally well tolerated, cardiac toxicity has occurred as a rare but potentially serious complication that limits its use in some patients. In this study, we detected new-onset mitral regurgitation in trastuzumab-treated patients. To our knowledge, there is no report or survey on new-onset mitral regurgitation during this treatment. We discussed the possible reasons for this newly described side effect of the drug in the light of left ventricular longitudinal global strain and papillary muscle dyssynchrony of the patient by detecting two-dimensional speckle tracking echocardiography.
authors.affiliation: Department of Cardiology, Kartal Kosuyolu Yuksek Ihtisas Heart Education and Research Hospital, Istanbul, Turkey.
authors.forename: Can Yucel
authors.initials: CY
authors.lastname: Karabay
authors.forename: Gonenc
authors.initials: G
authors.lastname: Kocabay
authors.forename: Arzu
authors.initials: A
authors.lastname: Kalayci
authors.forename: Regaip
authors.initials: R
authors.lastname: Zehir
authors.forename: Halil
authors.initials: H
authors.lastname: Tanboga
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D004452:Echocardiography; D005260:Female; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D010210:Papillary Muscles / Q000503:physiopathology*; D000068878:Trastuzumab; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068878:Trastuzumab