title: Antigen in chitosan coated liposomes enhances immune responses through parenteral immunization.
abstract: To overcome the limitations of the use of conventional liposomes chitosan coated egg yolk lecithin based liposomes were used as antigen carrier through parenteral administration in two animal models such as fish and rabbit. Extracellular proteins (ECPs) antigen of Aeromonas hydrophila encapsulated in liposomes became more stable and induced better immune response. It enhanced both adaptive and innate immune responses than other preparations both at 21, 42 and 63days post-immunization and suggested to be a better antigen delivery system.
authors.affiliation: Fish Health Management Division, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar-751 002, Orissa, India.
authors.forename: T
authors.initials: T
authors.lastname: Behera
authors.forename: P
authors.initials: P
authors.lastname: Swain
authors.forename: S K
authors.initials: SK
authors.lastname: Sahoo
mesh_terms: D016980:Aeromonas hydrophila; D000818:Animals; D000906:Antibodies / Q000276:immunology; D000942:Antigens, Bacterial / Q000008:administration & dosage* / Q000737:chemistry / Q000276:immunology*; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry*; D004530:Egg Yolk / Q000737:chemistry; D005399:Fishes; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology; D007114:Immunization / Q000379:methods*; D007263:Infusions, Parenteral / Q000379:methods; D054709:Lecithins / Q000008:administration & dosage; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry*; D011817:Rabbits
chemical_list: D000906:Antibodies; D000942:Antigens, Bacterial; D054709:Lecithins; D008081:Liposomes; D048271:Chitosan