title: [Pharmacodynamic experiment of the antivirus effect of Houttuynia cordata injection on influenza virus in mice].
abstract: It is to investigate the effect of two kinds of Houttuynia Cordata Injection on preventing and treating H1N1 influenza virus infection in mice. Pneumonia model was set up by intranasal infection of the normal and immunocompromised mice with influenza virus FM1 and PR8. The two injections were administered before and after the administration of virus, separately, and the lung index was observed. The results showed that the two preparations have obvious therapeutic effect on normal mice infected with influenza virus FM1 and PR8. And to FM1, the new injection's effect is better at small dosage. The results also showed that the two preparations have obvious prophylactic effect on immunodepressed mice infected with influenza virus FM1 and PR8. And to PR8, the old injection's effect is better at small dosage. Houttuynia Cordata Injection can improve the mice pneumonia caused by influenza virus H1N1 and decrease the lung index markedly. It has a remarkable preventive and therapeutic effect on H1N1 influenza virus in mice.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Fang-zhou
authors.initials: FZ
authors.lastname: Liu
authors.forename: Han
authors.initials: H
authors.lastname: Shi
authors.forename: Yu-jing
authors.initials: YJ
authors.lastname: Shi
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Ya-hong
authors.initials: YH
authors.lastname: Jin
authors.forename: Ying-jie
authors.initials: YJ
authors.lastname: Gao
authors.forename: Shan-shan
authors.initials: SS
authors.lastname: Guo
authors.forename: Xiao-lan
authors.initials: XL
authors.lastname: Cui
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D052859:Houttuynia / Q000737:chemistry*; D016867:Immunocompromised Host; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000276:immunology; D007267:Injections; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D010946:Plants, Medicinal / Q000737:chemistry; D011024:Pneumonia, Viral / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D011897:Random Allocation
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; C442781:Houttuynia cordata extract