title: [Efficacy of sublingual nifedipine and intravenous urapidil for treatment of acute postoperative hypertension].
abstract: OBJECTIVE
  To compare the clinical efficacy and safety of sublingual nifedipine and intravenous urapidil in the treatment of acute postoperative hypertension.
  
  
  METHODS
  The clinical data of 215 patients with APH after tumorectomy were retrospectively analyzed, among whom 165 were treated with sublingual nifedipine and 50 with intravenously urapidil.
  
  
  RESULTS
  Treatment with sublingual nifedipine caused a reduction of the systolic blood pressure by 5.9% and diastolic blood pressure by 5.2%. Urapidil treatment resulted in significantly greater reductions in the systolic and diastolic blood pressures (by 12.1% and 8.6%, respectively) (P(s)<0.001, P(d)=0.019). Urapidil treatment was associated with a significantly higher rate of adequate antihypertensive effect than nifedipine treatment (68% vs 35.8%, P<0.001).
  
  
  CONCLUSIONS
  Although both urapidil and nifedipine are associated with minimal adverse effects, intravenous urapidil shows better therapeutic effect than sublingual nifedipine and is more suitable for the treatment of APH.
authors.affiliation: Sun Yat-sen University, Guangzhou 510060, China. guangwangzhi123@163.com
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.forename: Dao-feng
authors.initials: DF
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Lou
mesh_terms: D000286:Administration, Sublingual; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000601:surgery; D009543:Nifedipine / Q000008:administration & dosage*; D010879:Piperazines / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; C015568:urapidil; D009543:Nifedipine