title: Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiety conjugated addition.
abstract: The catalytic asymmetric aza-Michael reaction of benzoyl hydrazine toward chalcones through the nonactivated amine moiety conjugated addition was facilitated by the developed N,N'-dioxide-Sc(OTf)(3) complex under mild conditions, affording the pharmacologically and synthetically useful products in moderate to high yields with up to 97% ee.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Cai
authors.forename: Weiliang
authors.initials: W
authors.lastname: Chen
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D000588:Amines / Q000737:chemistry*; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D047188:Chalcones; D006834:Hydrazines; C029424:hydrazine