title: How Institut Georges Lopez preservation solution protects nonsteatotic and steatotic livers against ischemia-reperfusion injury.
abstract: The Institut Georges Lopez preservation solution (IGL-1) is a serum-free organ preservative that has been shown to protect steatotic livers against hepatic ischemia-reperfusion injury. Although several hypotheses have been proposed to explain the graft protection mechanisms induced by IGL-1 solution, they have not been fully investigated. This review assessed possible IGL-1 mechanisms responsible for the increased liver tolerance of ischemia-reperfusion injury with special emphasis on vasodilatator mediators such as nitric oxide, on oxidative stress prevention, on protection against mitochondrial damage, and finally on induction of cytoprotective factors.
authors.affiliation: Experimental Hepatic Ischemia-Reperfusion Unit, Institut d'Investigacions Biomèdiques de Barcelona, Consejo Superior de Investigaciones Científicas, Barcelona, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Zaouali
authors.forename: H
authors.initials: H
authors.lastname: Ben Abdennebi
authors.forename: S
authors.initials: S
authors.lastname: Padrissa-Altés
authors.forename: I
authors.initials: I
authors.lastname: Alfany-Fernandez
authors.forename: A
authors.initials: A
authors.lastname: Rimola
authors.forename: J
authors.initials: J
authors.lastname: Roselló-Catafau
mesh_terms: D005234:Fatty Liver / Q000150:complications*; D006801:Humans; D019188:Organ Preservation Solutions; D015427:Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*
chemical_list: C504757:IGL-1 solution; D019188:Organ Preservation Solutions