title: Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass.
abstract: OBJECTIVE
  Genetic variation in the fatty acid translocase (CD36) gene has been shown in animal models to affect several risk factors for the development of left-ventricular hypertrophy, but this phenotype has not, thus far, been investigated in humans. We examined the relationship between common genetic polymorphisms in the CD36 gene and left-ventricular mass.
  
  
  RESULTS
  We studied a cohort of 255 families comprising 1425 individuals ascertained via a hypertensive proband. Seven single-nucleotide polymorphisms which together tagged common genetic variation in the CD36 gene were genotyped using a SEQUENOM MALDI-TOF instrument. There was evidence of association between the rs1761663 polymorphism in intron 1 of the CD36 gene and left-ventricular mass determined either by echocardiography (P=0.003, N=780) or electrocardiography (P=0.001, N=814). There was also association between rs1761663 genotype and body mass index (P<0.001, N=1354). Genotype was associated with between 2 and 8% differences in these phenotypes per allele. After adjustment for the effect of body mass index, there remained significant associations between genotype and left ventricular mass measured either by echo (P=0.017) or ECG (P=0.007).
  
  
  CONCLUSIONS
  Genotype at the rs1761663 polymorphism has independent effects both on body mass index and left-ventricular mass. Genes with such pleiotropic effects may be particularly attractive therapeutic targets for interventions to modify multiple risk factors for cardiovascular events.
authors.affiliation: Institute of Human Genetics, Newcastle University, UK.
authors.forename: Darroch
authors.initials: D
authors.lastname: Hall
authors.forename: Bongani M
authors.initials: BM
authors.lastname: Mayosi
authors.forename: Thahira J
authors.initials: TJ
authors.lastname: Rahman
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Avery
authors.forename: Hugh C
authors.initials: HC
authors.lastname: Watkins
authors.forename: Bernard
authors.initials: B
authors.lastname: Keavney
mesh_terms: D018955:CD36 Antigens / Q000235:genetics*; D015331:Cohort Studies; D004562:Electrocardiography; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D007438:Introns; D009929:Organ Size / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
chemical_list: D018955:CD36 Antigens