title: Hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in the United States--September-October 2009.
abstract: Given the potential worsening clinical severity of 2009 pandemic influenza A (H1N1) virus (pH1N1) infection from spring to fall 2009, we conducted a clinical case series among patients hospitalized with pH1N1 infection from September through October 2009. A case patient was defined as a hospitalized person who had test results positive for pH1N1 virus by real-time reverse-transcription polymerase chain reaction. Among 255 hospitalized patients, 34% were admitted to an intensive care unit and 8% died. Thirty-four percent of patients were children <18 years of age, 8% were adults ≥ 65 years of age, and 67% had an underlying medical condition. Chest radiographs obtained at hospital admission that had findings that were consistent with pneumonia were noted in 103 (46%) of 255 patients. Among 255 hospitalized patients, 208 (82%) received neuraminidase inhibitors, but only 47% had treatment started ≤ 2 days after illness onset. Overall, characteristics of hospitalized patients with pH1N1 infection in fall 2009 were similar to characteristics of patients hospitalized with pH1N1 infection in spring 2009, which suggests that clinical severity did not change substantially over this period.
authors.affiliation: Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
authors.forename: Jacek
authors.initials: J
authors.lastname: Skarbinski
authors.forename: Seema
authors.initials: S
authors.lastname: Jain
authors.forename: Anna
authors.initials: A
authors.lastname: Bramley
authors.forename: Esther J
authors.initials: EJ
authors.lastname: Lee
authors.forename: Jean
authors.initials: J
authors.lastname: Huang
authors.forename: David
authors.initials: D
authors.lastname: Kirschke
authors.forename: Allison
authors.initials: A
authors.lastname: Stone
authors.forename: Tiffany
authors.initials: T
authors.lastname: Wedlake
authors.forename: Shawn M
authors.initials: SM
authors.lastname: Richards
authors.forename: Shannon
authors.initials: S
authors.lastname: Page
authors.forename: Patti
authors.initials: P
authors.lastname: Ragan
authors.forename: Lesley
authors.initials: L
authors.lastname: Bullion
authors.forename: Daniel
authors.initials: D
authors.lastname: Neises
authors.forename: Robin M
authors.initials: RM
authors.lastname: Williams
authors.forename: Bruno P
authors.initials: BP
authors.lastname: Petruccelli
authors.forename: Meredith
authors.initials: M
authors.lastname: Vandermeer
authors.forename: Kathryn H
authors.initials: KH
authors.lastname: Lofy
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Gindler
authors.forename: Lyn
authors.initials: L
authors.lastname: Finelli
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000592:standards; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000821:virology*; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D058873:Pandemics; D011024:Pneumonia, Viral / Q000473:pathology; D013902:Radiography, Thoracic; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000998:Antiviral Agents