title: Localized tongue Amyloidosis in a Patient with Neurofibromatosis type II.
abstract: BACKGROUND
  Localized Amyloidosis (AL) may rarely involve oral mucosa. This is the first known reported case describing the development of tongue AL in a 30-year-old patient with Neurofibromatosis (NF) type-2.
  
  
  METHODS
  A female patient presented with a painless, well-circumscribed nodule of the tongue. Her medical history included NF type-2 with chromosome-22 abnormal karyotype (mosaicism), multiple intracranial and spinal meningiomas/schwannomas and unilateral blindness/deafness. The biopsy of the excised lesion of the tongue revealed subepithelial accumulation of an amorphous, nodular, fibrillar material positive for Congo red. Blood examination showed increased Thyroxine-T4 due to thyroid multinodular colloid goiter, but excluded any other hematological/immunological disorder or organ dysfunction. No recurrence was observed after a six-month follow-up.
  
  
  CONCLUSIONS
  This case highlights the possibility of oral manifestations as the only sign of AL and reveals the unexpected co-existence of AL and NF 2, for the first time.
authors.affiliation: Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. dandrea@dent.auth.gr
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Andreadis
authors.forename: Athanasios
authors.initials: A
authors.lastname: Poulopoulos
authors.forename: Petros
authors.initials: P
authors.lastname: Papadopoulos
authors.forename: Apostolos
authors.initials: A
authors.lastname: Epivatianos
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D016518:Neurofibromatosis 2 / Q000150:complications* / Q000473:pathology; D014060:Tongue Diseases / Q000150:complications* / Q000473:pathology*