title: NDRG2 expression regulates CD24 and metastatic potential of breast cancer cells.
abstract: Breast cancer is the most common malignancy in women in the world. High incidence and poor clinical outcomes underly the need for a better understanding of its tumor biology and how to effectively inhibit tumor progression. In the present study the question of whether NDRG2 might be a useful target for breast cancer therapy was addressed. With the increase or decrease of NDRG2 levels in MCF-7 and Bcap-37 cells by adenovirus-NDRG2 infection or NDRG2 siRNA transfection, CD24 expression was significantly decreased or increased, respectively. Furthermore, NDRG2 overexpression suppressed breast cancer cell adhesion and invasion, whereas knockdown of NDRG2 promoted these events. In conclusion, the data from the current study indicated that NDRG2, the product of a tumor suppressor gene, can regulate CD24 expression to decrease the metastatic potential of breast cancer cells.
authors.affiliation: Department of Oncology, Xijing Hospital, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zheng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jiandong
authors.initials: J
authors.lastname: Yang
authors.forename: Ji
authors.initials: J
authors.lastname: Ma
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.forename: Hengjun
authors.initials: H
authors.lastname: Shi
authors.forename: Qinyou
authors.initials: Q
authors.lastname: Ren
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Xue
authors.forename: Yurong
authors.initials: Y
authors.lastname: Tao
authors.forename: Ning
authors.initials: N
authors.lastname: Jiang
authors.forename: Hang
authors.initials: H
authors.lastname: Guo
authors.forename: LiBo
authors.initials: L
authors.lastname: Yao
authors.forename: Wenchao
authors.initials: W
authors.lastname: Liu
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D017209:Apoptosis; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D051927:CD24 Antigen / Q000235:genetics / Q000378:metabolism*; D002448:Cell Adhesion; D002453:Cell Cycle; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D051927:CD24 Antigen; C497889:CD24 protein, human; C466228:NDRG2 protein, human; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D025521:Tumor Suppressor Proteins