title: Evaluation of the role of magnetic resonance spectroscopy in the diagnosis of follicular malignancies of thyroid.
abstract: OBJECTIVE
  To evaluate role of magnetic resonance spectroscopy in differentiating benign from malignant follicular nodules.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Department of Surgery in collaboration with Department of Radio Diagnosis, Maulana Azad Medical College, Delhi, India.
  
  
  METHODS
  Twenty-five patients with a solitary thyroid nodule with follicular etiology.
  
  
  METHODS
  Magnetic resonance spectroscopy was carried out in all the cases, and its findings were compared with the final diagnosis based on histopathological examination of sample obtained at surgery.
  
  
  METHODS
  Choline peak detected on MRS.
  
  
  RESULTS
  There were 17 benign cases, 16 follicular adenomas, and 1 colloid goiter. Of the 17 benign cases, only 1 showed choline peak; however, all 8 follicular carcinoma cases showed prominent choline peak. Hence, the sensitivity is 100% while the specificity is 94.11%.
  
  
  CONCLUSIONS
  Magnetic resonance spectroscopy may prove to be a sensitive diagnostic tool in differentiating follicular adenomas from carcinomas.
authors.affiliation: Department of Surgery, Maulana Azad Medical College and Associated Hospitals, New Delhi, India. nikhil_ms26@yahoo.co.in
authors.forename: Nikhil
authors.initials: N
authors.lastname: Gupta
authors.forename: Binita
authors.initials: B
authors.lastname: Goswami
authors.forename: Veena
authors.initials: V
authors.lastname: Chowdhury
authors.forename: L
authors.initials: L
authors.lastname: Ravishankar
authors.forename: Arun
authors.initials: A
authors.lastname: Kakar
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis*; D000236:Adenoma / Q000175:diagnosis*; D000328:Adult; D002291:Carcinoma, Papillary / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D055815:Young Adult