title: Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation.
abstract: Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These molecules are recognized by the innate immune system by pattern recognition receptors - the same receptors that detect pathogen-associated molecular patterns, thus revealing similarities between pathogen-induced and non-infectious inflammatory responses. Many DAMPs are derived from the plasma membrane, nucleus, endoplasmic reticulum and cytosol. Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondrial DAMPs and discuss their contribution to inflammation and development of human pathologies.
authors.affiliation: Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Belgium. dmitri.krysko@ugent.be
authors.forename: Dmitri V
authors.initials: DV
authors.lastname: Krysko
authors.forename: Patrizia
authors.initials: P
authors.lastname: Agostinis
authors.forename: Olga
authors.initials: O
authors.lastname: Krysko
authors.forename: Abhishek D
authors.initials: AD
authors.lastname: Garg
authors.forename: Claus
authors.initials: C
authors.lastname: Bachert
authors.forename: Bart N
authors.initials: BN
authors.lastname: Lambrecht
authors.forename: Peter
authors.initials: P
authors.lastname: Vandenabeele
mesh_terms: D000818:Animals; D017209:Apoptosis; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D008928:Mitochondria / Q000276:immunology*; D009336:Necrosis; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species