title: Comparison of oral dydrogestrone with progesterone gel and micronized progesterone for luteal support in 1,373 women undergoing in vitro fertilization: a randomized clinical study.
abstract: OBJECTIVE
  To compare the efficacy of oral dydrogesterone with that of micronized vaginal P gel and micronized P capsule for luteal supplementation.
  
  
  METHODS
  Prospective, randomized clinical study.
  
  
  METHODS
  Institute of Reproductive Medicine, Kolkata, India.
  
  
  METHODS
  A total of 1,373 infertile women undergoing IVF participated.
  
  
  METHODS
  Micronized P gel, P capsule, and oral dydrogesterone were administered for luteal support and compared.
  
  
  METHODS
  Demographic profile and pregnancy and miscarriage rates.
  
  
  RESULTS
  The overall pregnancy rate and miscarriage rate were comparable among the three groups.
  
  
  CONCLUSIONS
  Oral dydrogesterone seems to be a promising drug for luteal support in woman undergoing IVF.
authors.affiliation: School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India.
authors.forename: Ashalatha
authors.initials: A
authors.lastname: Ganesh
authors.forename: Nishant
authors.initials: N
authors.lastname: Chakravorty
authors.forename: Rashmi
authors.initials: R
authors.lastname: Mukherjee
authors.forename: Sourendrakanta
authors.initials: S
authors.lastname: Goswami
authors.forename: Koel
authors.initials: K
authors.lastname: Chaudhury
authors.forename: Baidyanath
authors.initials: B
authors.lastname: Chakravarty
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D002214:Capsules; D004394:Dydrogesterone / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000009:adverse effects; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008183:Luteal Phase / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D014622:Vaginal Creams, Foams, and Jellies; D055815:Young Adult
chemical_list: D002214:Capsules; D005300:Fertility Agents, Female; D014622:Vaginal Creams, Foams, and Jellies; D011374:Progesterone; D004394:Dydrogesterone