title: Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel.
abstract: Levodopa/carbidopa (LD/CD) application elevates total plasma homocysteine (thcys). We determined thcys-, LD- and 3-O-methyldopa (3-OMD) concentrations in 28 patients with Parkinson's disease (PD) on a LD/CD duodenal gel treatment. We found a distinct thcys increase (29.52 ± 28.98 μmol/l [median ± SD]) above the 15 μmol/l threshold and a significant (R = 0.7) correlation between LD and 3-OMD. thcys ascent was observed in relation with the onset of atherosclerosis, non-motor symptoms and polyneuropathy in PD patients in the long term.
authors.affiliation: Department of Neurology, St. Joseph Hospital, Berlin-Weissensee, Gartenstr. 1, 13088, Berlin, Germany. th.mueller@alexius.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Müller
authors.forename: Constanze
authors.initials: C
authors.lastname: Jugel
authors.forename: Reinhard
authors.initials: R
authors.lastname: Ehret
authors.forename: Georg
authors.initials: G
authors.lastname: Ebersbach
authors.forename: Gunar
authors.initials: G
authors.lastname: Bengel
authors.forename: Siegfried
authors.initials: S
authors.lastname: Muhlack
authors.forename: Fabian
authors.initials: F
authors.lastname: Klostermann
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002230:Carbidopa / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D004338:Drug Combinations; D004386:Duodenum; D005260:Female; D005782:Gels / Q000008:administration & dosage; D006710:Homocysteine / Q000096:biosynthesis / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000139:chemically induced*; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D008297:Male; D008750:Methyldopa / Q000097:blood; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000188:drug therapy*
chemical_list: D000978:Antiparkinson Agents; D004338:Drug Combinations; D005782:Gels; C009265:carbidopa, levodopa drug combination; D006710:Homocysteine; D007980:Levodopa; D008750:Methyldopa; D002230:Carbidopa