title: A population-based case-crossover study of polyethylene glycol use and acute renal failure risk in the elderly.
abstract: OBJECTIVE
  To evaluate the possibility of an association between polyethylene glycol (PEG) and acute renal failure (ARF) in elderly patients using a health insurance claims database.
  
  
  METHODS
  We conducted a population-based case-crossover study using information obtained from Korean Health Insurance Review and Assessment Service (HIRA) claims from January 1, 2005 to December 31, 2005 (Seoul, Korea). The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1, 2005 to December 31, 2005. For each patient, one case and two control periods were matched. PEG use in a 2- or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2- or 4-wk control window periods. Conditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% CI, adjusting for concomitant uses of diuretics, angiotensin converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, antibiotics, anti-cancer drugs, and contrast media.
  
  
  RESULTS
  Within the HIRA database which contained 1,093,262 elderly patients, 1156 hospitalized ARF cases were identified. Among these cases, PEG was prescribed to 17 (1.5%) patients before hospitalization. The adjusted ORs when applying the 2- and 4-wk window periods were 0.4 (95% CI: 0.03-5.24) and 2.1 (95% CI: 0.16-27.78), respectively.
  
  
  CONCLUSIONS
  No increased risk of ARF was found in elderly PEG users. However, based on the limited number of study subjects, further analysis should be performed to confirm these results.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, and Department of Occupational Medicine, Health Screening Center, Kangbuk Samsung Hospital, Seoul 110-799, South Korea.
authors.forename: Nam-Kyong
authors.initials: NK
authors.lastname: Choi
authors.forename: Yoosoo
authors.initials: Y
authors.lastname: Chang
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Jung
authors.forename: Yu-Kyong
authors.initials: YK
authors.lastname: Choi
authors.forename: Joongyub
authors.initials: J
authors.lastname: Lee
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Park
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002400:Cathartics / Q000009:adverse effects*; D003113:Colonoscopy; D018592:Cross-Over Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007345:Insurance Claim Review; D008297:Male; D011092:Polyethylene Glycols / Q000009:adverse effects*; D056910:Republic of Korea; D012307:Risk Factors
chemical_list: D002400:Cathartics; D011092:Polyethylene Glycols