title: Vascular IL-10: a protective role in preeclampsia.
abstract: IL-10 is a pregnancy compatible cytokine that plays a vital role in maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the maternal-fetal interface. Recent evidence now suggests that IL-10 is a potent vascular cytokine that can blunt hypertension and inflammation-mediated vascular dysfunction. Thus, a re-evaluation of IL-10 as a cytokine supporting endovascular interactions and angiogenesis as well as blunting hypoxic-injury and preeclampsia-like features is warranted. In this review, we highlight these novel functions of IL-10 and propose that its immune-modulating and vascular functions are mutually inclusive, particularly in the context of normal gestation.
authors.affiliation: Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, Providence, RI 02905, USA.
authors.forename: Satyan
authors.initials: S
authors.lastname: Kalkunte
authors.forename: Tania
authors.initials: T
authors.lastname: Nevers
authors.forename: Wendy E
authors.initials: WE
authors.lastname: Norris
authors.forename: Surendra
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000818:Animals; D019610:Cytoprotection; D042783:Endothelial Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension; D000860:Hypoxia; D007108:Immune Tolerance; D007167:Immunotherapy / Q000639:trends; D007249:Inflammation; D016753:Interleukin-10 / Q000276:immunology* / Q000627:therapeutic use; D018919:Neovascularization, Physiologic / Q000276:immunology; D010920:Placenta / Q000098:blood supply / Q000276:immunology* / Q000473:pathology; D010929:Placentation; D011225:Pre-Eclampsia / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D011247:Pregnancy
chemical_list: D016753:Interleukin-10