title: Childhood ovarian juvenile granulosa cell tumor: a retrospective study with 3 cases including clinical features, pathologic results, and therapies.
abstract: Ovarian juvenile granulosa cell tumor (JGCT) is an extremely rare sex cord-stromal tumor that is most commonly encountered in prepubertal girls and young women. In this study, 3 cases of childhood JGCT are reported. The main causes of hospitalization were abnormal abdominal signs and syndromes. Imaging findings indicated masses with multiple cysts and solid components in the abdominal cavities. Diagnosis was confirmed by histopathology. Tumors were excised completely, and all cases have a good outcome in the follow-up (2 to 13 y) without any adjuvant chemotherapy or radiotherapy. This data suggests that children with JGCT might have a variety of initial clinical manifestations. Pathologic examination especially immunohistochemical staining could help to diagnose JGCT. For children, adjuvant treatment may not be necessary if the tumor can be excised completely in early stage.
authors.affiliation: Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Weiya
authors.initials: W
authors.lastname: Wang
authors.forename: Chang
authors.initials: C
authors.lastname: Xu
authors.forename: Xiaoran
authors.initials: X
authors.lastname: Huang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhong
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Kang
authors.forename: Zhoujian
authors.initials: Z
authors.lastname: Yang
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D002675:Child, Preschool; D004958:Estradiol / Q000097:blood; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D007223:Infant; D009367:Neoplasm Staging; D012189:Retrospective Studies
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D004958:Estradiol