title: Phenytoin toxicity presenting as acute meningo-encephalitis in children.
abstract: Phenytoin can produce significant dose-related toxicity because of its zero order pharmacokinetics and is an important issue in pediatric emergency medicine. It is important to differentiate phenytoin toxicity manifesting with symptoms like fever, vomiting, seizures, ataxia masquerading as acute meningo-encephalitic illness, more so at centers where facilities to measure serum phenytoin levels are not available. Here we describe two children with phenytoin toxicity, presenting to the emergency department with features suggestive of acute meningo-encephalitis.
authors.affiliation: Department of Pediatrics and Neonatology, PGIMER and Associated Dr. Ram Manohar Lohia Hospital, New Delhi, India. yzaygupta@gmail.com
authors.forename: Vijay
authors.initials: V
authors.lastname: Gupta
authors.forename: Tribhuvan P
authors.initials: TP
authors.lastname: Yadav
authors.forename: Anita
authors.initials: A
authors.lastname: Yadav
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002675:Child, Preschool; D004660:Encephalitis / Q000139:chemically induced*; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin