title: Delirium and sedation in the ICU.
abstract: Delirium is defined by a fluctuating level of attentiveness and has been associated with increased ICU mortality and poor cognitive outcomes in both general ICU and neurocritical care populations. Sedation use in the ICU can contribute to delirium. Limiting ICU sedation allows for the diagnosis of underlying acute neurological insults associated with delirium and leads to shorter mechanical ventilation time, shorter length of stay, and improved 1 year mortality rates. Identifying the underlying etiology of delirium is critical to developing treatment paradigms.
authors.affiliation: Neuroscience Intensive Care Unit, Departments of Neurosurgery and Neurology, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1136, New York, NY 10029, USA. Jennifer.Frontera@mountsinai.org
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Frontera
mesh_terms: D016292:Procedural Sedation / Q000009:adverse effects*; D003693:Delirium / Q000139:chemically induced* / Q000175:diagnosis / Q000401:mortality; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000009:adverse effects; D003937:Diagnosis, Differential; D017052:Hospital Mortality; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects; D007362:Intensive Care Units; D008140:Lorazepam / Q000008:administration & dosage / Q000009:adverse effects; D008874:Midazolam / Q000008:administration & dosage / Q000009:adverse effects; D009460:Neurologic Examination / Q000187:drug effects; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D008140:Lorazepam; D008874:Midazolam