title: Brain tumor imaging using small-angle x-ray scattering tomography.
abstract: We demonstrate high-resolution small-angle x-ray scattering computed tomography (SAXS-CT) of soft matter and soft tissue samples. Complete SAXS patterns over extended ranges of momentum transfer are reconstructed spatially resolved from volumes inside an extended sample. Several SAXS standard samples are used to quantitatively validate the method and demonstrate its performance. Further results on biomedical tissue samples (rat brains) are presented that demonstrate the advantages of the method compared to existing biomedical x-ray imaging approaches. Functional areas of the brains as well as tumor morphology are imaged. By providing insights into the structural organization at the nano-level, SAXS-CT complements and extends results obtainable with standard methods such as x-ray absorption tomography and histology.
authors.affiliation: Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark. torbenj@fys.ku.dk
authors.forename: Torben H
authors.initials: TH
authors.lastname: Jensen
authors.forename: Martin
authors.initials: M
authors.lastname: Bech
authors.forename: Oliver
authors.initials: O
authors.lastname: Bunk
authors.forename: Maria
authors.initials: M
authors.lastname: Thomsen
authors.forename: Andreas
authors.initials: A
authors.lastname: Menzel
authors.forename: Audrey
authors.initials: A
authors.lastname: Bouchet
authors.forename: Géraldine
authors.initials: G
authors.lastname: Le Duc
authors.forename: Robert
authors.initials: R
authors.lastname: Feidenhans'l
authors.forename: Franz
authors.initials: F
authors.lastname: Pfeiffer
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003102:Colloids / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D008297:Male; D008823:Micelles; D019047:Phantoms, Imaging; D051381:Rats; D053838:Scattering, Small Angle; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*; D014961:X-Ray Diffraction
chemical_list: D003102:Colloids; D005227:Fatty Acids; D008823:Micelles; C007547:behenic acid