title: Bioactive diterpenes from Clerodendrum kaichianum.
abstract: Bioassay-guided isolation studies of the extract of Clerodendrum kaichianum Hsu., a new rearranged abietane diterpene and five known diterpene compounds were isolated by various chromatography methods. Their structures were identified by means of spectroscopic methods, including 1D- and 2D-NMR spectroscopy, as (16R)-12,16-epoxy-11,14,17-trihydroxy-17(15-->16)-abeo-8,11,13-abietatrien-7-one (1), villosin A (2), salvinolone (3), 14-deoxyloleon U (4), 5,6-dehydrosugiol (5), and coleon U (6). Compounds 1, 2, 3, and 5 are reported for the first time for this genus. Compounds 1, 2, and 6 demonstrated potent cytotoxic activities against the HL-60 tumor cell line.
authors.affiliation: College of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou 310035, China.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Xu
authors.forename: Lianqing
authors.initials: L
authors.lastname: Shen
authors.forename: Kuiwu
authors.initials: K
authors.lastname: Wang
authors.forename: Qizhen
authors.initials: Q
authors.lastname: Du
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D032409:Clerodendrum / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes