title: Drug-induced leukoencephalopathy presenting as catatonia.
abstract: We discuss the case of a 35-year-old woman who presented with thought impoverishment, disorganized behavior, and echolalia. The patient's condition progressed to treatment-refractory catatonia. She was started on oral Coenzyme Q10 after magnetic resonance imaging of the brain showed findings consistent with drug-induced leukoencephalopathy (DIL). Following improvement, she acknowledged cocaine use that suggested a diagnosis of cocaine-induced leukoencephalopathy (CIL). This case report seeks to elucidate radiological and clinical features of DIL.
authors.affiliation: Department of Neurology, NYU School of Medicine, New York, NY 10016, USA. da446@med.nyu.edu
authors.forename: Deepti
authors.initials: D
authors.lastname: Anbarasan
authors.forename: Paul
authors.initials: P
authors.lastname: Campion
authors.forename: Jonathan
authors.initials: J
authors.lastname: Howard
mesh_terms: D000328:Adult; D002389:Catatonia; D003042:Cocaine / Q000009:adverse effects*; D003937:Diagnosis, Differential; D018765:Dopamine Uptake Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D011859:Radiography; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D018765:Dopamine Uptake Inhibitors; D014451:Ubiquinone; C024989:coenzyme Q10; D003042:Cocaine