title: Synthetic studies on indolocarbazoles: total synthesis of staurosporine aglycon.
abstract: A synthesis of staurosporine aglycon and its analogs was achieved in a 28-36% overall yield starting from 2-methylindole. The prominent key steps for the synthesis of the indolocarbazole alkaloids involved electrocyclization and nitrene insertion reactions.
authors.affiliation: Department of Organic Chemistry, School of Chemistry, University of Madras, Guindy Campus Chennai 600 025, Tamil Nadu, India.
authors.forename: Ganesan Gobi
authors.initials: GG
authors.lastname: Rajeshwaran
authors.forename: Arasambattu K
authors.initials: AK
authors.lastname: Mohanakrishnan
mesh_terms: D001965:Bromides / Q000737:chemistry; D002227:Carbazoles / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D001965:Bromides; D002227:Carbazoles; D007211:Indoles; D017967:Zinc Compounds; D019311:Staurosporine; C022958:2-methylindole; C093802:zinc bromide