title: [Distribution and accumulation of vindoline, catharanthine and vinblastine in Catharanthus roseus cultivated in China].
abstract: OBJECTIVE
  The content of vindoline, catharanthine and vinblastine in the root, stem, leaf, flower and fruit of Catharanthus roseus at various developmental stages were determined, and the biomass allocation was also determined to find the best harvest time.
  
  
  METHODS
  The content of vindoline, catharanthine and vinblastine in the root, stem, leaf, flower and fruit of C. roseus were determined by HPLC.
  
  
  RESULTS
  The content of these alkaloids were influenced by season and it varied in the different tissues of the plant. The content of vindoline and catharanthine in the leaves were the highest, and there was no vindoline detected in the root, but the content of vinblastine in the flower was the highest; the content of vindoline and catharanthine reached the maximum between the August and September, and the content of vinblastine reached the highest after the September. The biomass was the highest in the initial stage of September.
  
  
  CONCLUSIONS
  The best harvest time was in the initial stage of September.
authors.affiliation: Key Laboratory of Forest Plant Ecology of Ministry of Education, Northeast Forestry University, Harbin 150040, China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yu
authors.forename: Shusheng
authors.initials: S
authors.lastname: Yuan
authors.forename: Haihe
authors.initials: H
authors.lastname: Pang
authors.forename: Xueke
authors.initials: X
authors.lastname: Zhang
authors.forename: Xueying
authors.initials: X
authors.lastname: Jia
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Tang
authors.forename: Yuangang
authors.initials: Y
authors.lastname: Zu
mesh_terms: D030008:Catharanthus / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D002681:China; D002851:Chromatography, High Pressure Liquid; D035264:Flowers / Q000737:chemistry / Q000254:growth & development / Q000378:metabolism; D010936:Plant Extracts / Q000032:analysis* / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry / Q000254:growth & development / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry / Q000254:growth & development / Q000378:metabolism; D012621:Seasons; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000378:metabolism; D014748:Vinca Alkaloids / Q000032:analysis* / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D014748:Vinca Alkaloids; C009667:vindoline; D014747:Vinblastine; C017836:catharanthine