title: Surface modification to control protein/surface interactions.
abstract: Protein/surface interactions are well known to play an important role in various biological phenomena and to determine the ultimate biofunctionality of a given material once it is in contact with a biological environment. Control over the interactions between proteins and material surfaces are not only of great theoretical interest but also of crucial importance for many biomedical applications. In this Feature Article, we summarize various successful approaches used in our laboratory and other groups for controlling protein adsorption through chemical modification of the surface and/or the introduction of specific topographic features. Some perspectives on future research in these areas are also presented.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Soochow University, Suzhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
authors.forename: Qian
authors.initials: Q
authors.lastname: Yu
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000032:analysis / Q000138:chemical synthesis*; D002448:Cell Adhesion; D002478:Cells, Cultured; D004129:Dimethylpolysiloxanes / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D008689:Methacrylates; D011506:Proteins; C013830:baysilon