title: MC3T3-E1 cell differentiation and in vivo bone formation induced by phosphoserine.
abstract: Bone formation induced by phosphoserine was investigated in vitro and in vivo using MC3T3-E1 cells and a rabbit calvarial osseous defect model. MC3T3-E1 cells supplemented by phosphoserine displayed two-fold higher alkaline phosphatase activity and mineralization nodule formation, and calvarial defects treated with phosphoserine showed statistically significant new bone formation compared with the control (P < 0.05).
authors.affiliation: Department of Periodontology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea. jinwoo@knu.ac.kr
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Youn-Jeong
authors.initials: YJ
authors.lastname: Kim
authors.forename: Je-Hee
authors.initials: JH
authors.lastname: Jang
authors.forename: Chang-Hyeon
authors.initials: CH
authors.lastname: An
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002113:Calcification, Physiologic / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D006651:Histocytochemistry; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects*; D010768:Phosphoserine / Q000008:administration & dosage / Q000378:metabolism*; D011817:Rabbits; D012886:Skull / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects
chemical_list: D010768:Phosphoserine; D000469:Alkaline Phosphatase