title: Effect of ceftobiprole treatment on growth of and toxin production by Clostridium difficile in cecal contents of mice.
abstract: Ceftobiprole and ceftobiprole medocaril did not promote growth of or toxin production by Clostridium difficile in mouse cecal contents, whereas ceftazidime, cefoxitin, ceftriaxone, cefotaxime, and ertapenem did. The relatively low propensity of ceftobiprole to promote C. difficile was attributable to inhibitory activity against C. difficile and sparing of anaerobic microflora.
authors.affiliation: Research Service, Cleveland VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Nerandzic
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Donskey
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002432:Cecum / Q000382:microbiology*; D002511:Cephalosporins / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects*; D005260:Female; D051379:Mice; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C443755:ceftobiprole; C505439:ceftobiprole medocaril