title: [Evaluation of coronary bed function by positron emission tomography using 13N-ammonium during cold stimulation].
abstract: The purpose of the present investigation was to study the time course of changes in myocardial blood flow (MBF) in response to cold stimulation. Thirty-eight patients having risk factors of cardiovascular complications were examined. The time course of MBF changes was estimated by positron emission tomography (PET) using 13N-ammonium at rest and during a cold test (CT). Endothelium-dependent vasodilation of the brachial artery was determined from the results of a reactive hyperemia test, by applying ultrasound duplex scanning. No significant MBF increase in response to the cold test was an indicator of coronary arterial endothelial dysfunction at cardiac 13N-ammonium PET. Agreement of the results of brachial arterial ultrasonography during reactive hyperemia and cardiac 13N-ammonium PET in the presence of the cold test suggests that endothelial dysfunction is generalized. Cardiovascular risk factors, such as left ventricular hypertrophy, smoking, dyslipidemia, and diabetes mellitus, substantially affect coronary arterial function. Left ventricular hypertrophy is an independent factor that influences the amount of the coronary reserve and, in combination with endothelial dysfunction, worsens coronary microcirculation.
authors.forename: D V
authors.initials: DV
authors.lastname: Ryzhkova
authors.forename: L A
authors.initials: LA
authors.lastname: Krasil'nikova
authors.forename: E M
authors.initials: EM
authors.lastname: Nifontov
authors.forename: L A
authors.initials: LA
authors.lastname: Tiutin
authors.forename: I E
authors.initials: IE
authors.lastname: Itskovich
mesh_terms: D000328:Adult; D000641:Ammonia; D003080:Cold Temperature; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007554:Isotopes; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D014655:Vascular Resistance / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
chemical_list: D007554:Isotopes; D000641:Ammonia