title: Monte Carlo-based fluorescence molecular tomography reconstruction method accelerated by a cluster of graphic processing units.
abstract: High-speed fluorescence molecular tomography (FMT) reconstruction for 3-D heterogeneous media is still one of the most challenging problems in diffusive optical fluorescence imaging. In this paper, we propose a fast FMT reconstruction method that is based on Monte Carlo (MC) simulation and accelerated by a cluster of graphics processing units (GPUs). Based on the Message Passing Interface standard, we modified the MC code for fast FMT reconstruction, and different Green's functions representing the flux distribution in media are calculated simultaneously by different GPUs in the cluster. A load-balancing method was also developed to increase the computational efficiency. By applying the Fréchet derivative, a Jacobian matrix is formed to reconstruct the distribution of the fluorochromes using the calculated Green's functions. Phantom experiments have shown that only 10 min are required to get reconstruction results with a cluster of 6 GPUs, rather than 6 h with a cluster of multiple dual opteron CPU nodes. Because of the advantages of high accuracy and suitability for 3-D heterogeneity media with refractive-index-unmatched boundaries from the MC simulation, the GPU cluster-accelerated method provides a reliable approach to high-speed reconstruction for FMT imaging.
authors.affiliation: Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, Wuhan 430074, China.
authors.forename: Guotao
authors.initials: G
authors.lastname: Quan
authors.forename: Hui
authors.initials: H
authors.lastname: Gong
authors.forename: Yong
authors.initials: Y
authors.lastname: Deng
authors.forename: Jianwei
authors.initials: J
authors.lastname: Fu
authors.forename: Qingming
authors.initials: Q
authors.lastname: Luo
mesh_terms: D003196:Computer Graphics; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods*; D009010:Monte Carlo Method; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods*