title: Increased thyroid function and elevated thyroid autoantibodies in pediatric patients with moyamoya disease: a case-control study.
abstract: OBJECTIVE
  The purpose of this study was to investigate whether thyroid function and thyroid autoantibodies were associated with the risk of moyamoya disease in pediatric subjects.
  
  
  METHODS
  Thyroid function and thyroid autoantibodies were evaluated in patients with moyamoya disease and control subjects, and their associations with moyamoya disease were estimated using multivariate analysis.
  
  
  RESULTS
  We included 114 pediatric patients and 114 healthy control subjects. The patients displayed higher prevalence of increased thyroid function and elevated thyroid autoantibodies in comparison with control subjects. These remained significant after multivariate adjustment; the ORs (95% CI) for increased thyroid function and evaluated thyroid autoantibodies were evaluated as 12.47 (1.55 to 100.51) and 4.33 (1.29 to 14.59), respectively.
  
  
  CONCLUSIONS
  Increased thyroid function and elevated thyroid autoantibodies are associated with moyamoya disease and therefore monitoring of thyroid function and thyroid autoantibodies in patients with moyamoya disease is suggested, which might help to guide subsequent clinical management.
authors.affiliation: Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Zheng-Shan
authors.initials: ZS
authors.lastname: Zhang
authors.forename: Zhen-Nan
authors.initials: ZN
authors.lastname: Dong
authors.forename: Mai-Juan
authors.initials: MJ
authors.lastname: Ma
authors.forename: Wei-Zhong
authors.initials: WZ
authors.lastname: Yang
authors.forename: Cong
authors.initials: C
authors.lastname: Han
authors.forename: Ming-Mei
authors.initials: MM
authors.lastname: Du
authors.forename: Yun-Xi
authors.initials: YX
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Lian
authors.initials: L
authors.lastname: Duan
authors.forename: Wu-Chun
authors.initials: WC
authors.lastname: Cao
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D008297:Male; D009072:Moyamoya Disease / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology* / Q000473:pathology; D015854:Up-Regulation / Q000276:immunology
chemical_list: D001323:Autoantibodies