title: Two patients with Hailey-Hailey disease, multiple primary melanomas, and other cancers.
abstract: BACKGROUND
  Hailey-Hailey Disease (HHD) is an autosomal dominant skin disorder that is characterized by erythematous and sometimes vesicular, weeping plaques of intertriginous regions. Squamous cell carcinoma and basal cell carcinoma arising in lesions of HHD have been described in the literature. To our knowledge, there are no reports of melanoma or noncutaneous malignant neoplasms associated with HHD.
  
  
  METHODS
  We discuss the mechanisms of oncogenicity, including genetic, environmental, and iatrogenic factors, in 2 patients with HHD, multiple primary melanomas, and other cancers. Patient 1 had a mucoepidermoid carcinoma of the parotid gland. Patient 2 had a history of acute monoblastic leukemia and malignant peripheral nerve sheath tumor as well as radiologic evidence of an acoustic neurilemmoma.
  
  
  CONCLUSIONS
  The cause of the cancers in these 2 patients is likely multifactorial. We describe the patients to draw attention to the possible association between HHD and cancer. Additional research should be performed to determine whether patients with HHD have an increased incidence of cancer.
authors.affiliation: Department of Dermatology, Eastern Virginia Medical School, Norfolk, VA 23507, USA. melinda.mohr@gmail.com
authors.forename: Melinda R
authors.initials: MR
authors.lastname: Mohr
authors.forename: Gulsun
authors.initials: G
authors.lastname: Erdag
authors.forename: Amber L
authors.initials: AL
authors.lastname: Shada
authors.forename: Michael E
authors.initials: ME
authors.lastname: Williams
authors.forename: Craig L
authors.initials: CL
authors.lastname: Slingluff
authors.forename: James W
authors.initials: JW
authors.lastname: Patterson
mesh_terms: D000328:Adult; D000368:Aged; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D018317:Nerve Sheath Neoplasms / Q000473:pathology; D009464:Neuroma, Acoustic / Q000473:pathology; D010307:Parotid Neoplasms / Q000473:pathology; D016506:Pemphigus, Benign Familial / Q000150:complications*; D012878:Skin Neoplasms / Q000473:pathology*