title: Fatty acid detection during food consumption and digestion: Associations with ingestive behavior and obesity.
abstract: The inability of humans to adequately regulate fat consumption is a salient contributor to the development of obesity. The macronutrients, fat, protein and carbohydrate, within foods are detected at various stages of consumption, during which their digestive products, fatty acids, amino acids and sugars, interact with chemosensory cells within the oral epithelium (taste receptor cells) and gastrointestinal (GI) tract (enteroendocrine cells). This chemoreception initiates functional responses, including taste perception, peptide secretion and alterations in GI motility, that play an important role in liking of food, appetite regulation and satiety. This review will summarize the available evidence relating to the oral and GI regulation of fat intake and how chemoreception at both locations is associated with digestive behavior, satiety and weight regulation.
authors.affiliation: Centre for Physical Activity and Nutrition Research, Sensory Science Group, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Stewart
authors.forename: Christine
authors.initials: C
authors.lastname: Feinle-Bisset
authors.forename: Russell S J
authors.initials: RS
authors.lastname: Keast
mesh_terms: D000818:Animals; D002628:Chemoreceptor Cells / Q000502:physiology; D004041:Dietary Fats / Q000008:administration & dosage*; D004063:Digestion / Q000502:physiology*; D004435:Eating; D005227:Fatty Acids / Q000008:administration & dosage*; D005247:Feeding Behavior; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D009765:Obesity / Q000209:etiology / Q000503:physiopathology*; D012527:Satiation; D013649:Taste / Q000502:physiology*; D055697:Taste Perception
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids