title: Peripherally acting therapies for the treatment of irritable bowel syndrome.
abstract: Gut-acting therapies are common therapies for irritable bowel syndrome (IBS). Most of these peripheral acting agents are primarily targeted at individual symptoms. The evidence supporting the use of these agents in IBS is largely anecdotal. Serotonergic agents and the chloride channel activator lubiprostone have shown efficacy in treating symptoms of IBS. The clinical evidence supporting the use of these agents is based on data from high-quality clinical trials. The use of serotonergic agents for IBS in the United States is limited to the 5-hydroxytryptamine-3 antagonist alosetron in the treatment of women with severe IBS with diarrhea refractory to traditional therapy.
authors.affiliation: Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 1500 East Medical Center Drive, SPC 5362, Ann Arbor, MI 48109, USA. rsaad@umich.edu
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Saad
mesh_terms: D000527:Alprostadil / Q000031:analogs & derivatives / Q000627:therapeutic use; D000930:Antidiarrheals / Q000627:therapeutic use; D002243:Carbolines / Q000627:therapeutic use; D004043:Dietary Fiber / Q000627:therapeutic use; D019587:Dietary Supplements; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D043183:Irritable Bowel Syndrome / Q000178:diet therapy / Q000188:drug therapy*; D054368:Laxatives / Q000627:therapeutic use; D000068238:Lubiprostone; D010276:Parasympatholytics / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use
chemical_list: D000930:Antidiarrheals; D002243:Carbolines; D004043:Dietary Fiber; D005765:Gastrointestinal Agents; D007211:Indoles; D054368:Laxatives; D010276:Parasympatholytics; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C090840:alosetron; C105050:tegaserod; D000068238:Lubiprostone; D000527:Alprostadil