title: Influence of catch-up growth on islet function and possible mechanisms in rats.
abstract: OBJECTIVE
  The purpose of this study was to examine how catch-up growth modulated islet function and what the detailed mechanisms were, especially at various stages and in different forms, of catch-up growth.
  
  
  METHODS
  We examined the modulation of islet function during catch-up growth by employing an oral glucose tolerance test and gained some insight into the possible mechanisms involved by measuring general physiologic parameters, pancreatic morphometry, insulin content, and the state of chronic oxidative stress. Correlation analyses were used to assess the correlation of insulin/glucose incremental area ratio to other parameters.
  
  
  RESULTS
  The catch-up growth groups resulted in damage to islet function as shown by an increased insulin/glucose incremental area ratio (P ≤ 0.05), smaller relative area of β-cells (P ≤ 0.05), larger relative area of α-cells (P ≤ 0.05), lower insulin content (P ≤ 0.05), increased nitric oxide and malondialdehyde concentrations, and decreased superoxide dismutase concentration (P ≤ 0.05, respectively). With time these changes became increasingly unmarked.
  
  
  CONCLUSIONS
  Catch-up growth in different stages and forms induces varying degrees of islet dysfunction, possibly by corresponding changes in general physiologic parameters, pancreatic morphometry, insulin content, and the state of chronic oxidative stress.
authors.affiliation: Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. cheria_chen@126.com
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Chen
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Yang
authors.forename: Juan
authors.initials: J
authors.lastname: Zheng
authors.forename: Jiao-Yue
authors.initials: JY
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Yue
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006128:Growth / Q000502:physiology*; D006130:Growth Disorders / Q000209:etiology / Q000503:physiopathology*; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000503:physiopathology*; D008297:Male; D044342:Malnutrition / Q000097:blood / Q000150:complications; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase