title: Human rhinovirus C--associated severe pneumonia in a neonate.
abstract: We present a case of severe pneumonia, associated with a prolonged infection by a species C rhinovirus (HRV) in a 3-week old neonate. HRV RNA was identified in nasal and nasopharyngeal secretions, bronchoalveolar lavage and bronchial specimens, stool and urine, collected from the patient during a one-month period. No other viral or bacterial agents were detected. Sequence analysis of two regions of the viral genome, amplified directly from the clinical specimens revealed a novel HRV-C variant. These observations highlight the occurrence of severe neonatal infections caused by HRVs and the need of rapid viral diagnostics for their detection.
authors.affiliation: Department of Virology, University of Turku, Kiinamyllynkatu 13, FI-20520 Turku, Finland.
authors.forename: Eeva
authors.initials: E
authors.lastname: Broberg
authors.forename: Jussi
authors.initials: J
authors.lastname: Niemelä
authors.forename: Elina
authors.initials: E
authors.lastname: Lahti
authors.forename: Timo
authors.initials: T
authors.lastname: Hyypiä
authors.forename: Olli
authors.initials: O
authors.lastname: Ruuskanen
authors.forename: Matti
authors.initials: M
authors.lastname: Waris
mesh_terms: D018450:Disease Progression; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010802:Phylogeny; D010850:Picornaviridae Infections / Q000175:diagnosis* / Q000235:genetics / Q000821:virology; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D012229:Rhinovirus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D017423:Sequence Analysis, RNA
chemical_list: D012367:RNA, Viral