title: Facilitating Clinical Research through the Health Information Exchange: Lipid Control as an Example.
abstract: Using data from the Indiana Network of Patient Care (INPC), we analyzed long-term statin adherence patterns and their effects on low-density lipoprotein cholesterol (LDL-C) control among patients with type 2 diabetes. Statin adherence was measured by proportion of days covered (PDC) for a 6-month interval prior to each LDL-C test date. Patient demographic and clinical characteristics were used as covariates for LDL-C control and predictors for statin adherence. From 4,350 eligible subjects, 25,596 6-month PDC and LDL-C level pairs were formed between 2001 and 2009. Rates of suboptimal adherence and suboptimal LDL-C control were 68.5% and 46.6%, respectively. Positive predictors for LDL-C control included adherence to statin (OR: 1.87, p<0.0001) and older age (OR: 1.11, p=0.01). Significant risk factors for non-adherence were young age, female gender, African American race and newly-treated status. This study demonstrated the utility of a health information exchange in health outcome and clinical effectiveness research.
authors.affiliation: Regenstrief Institute and.
authors.forename: Vivienne J
authors.initials: VJ
authors.lastname: Zhu
authors.forename: Wanzhu
authors.initials: W
authors.lastname: Tu
authors.forename: Marc B
authors.initials: MB
authors.lastname: Rosenman
authors.forename: J Marc
authors.initials: JM
authors.lastname: Overhage
mesh_terms: D008078:Cholesterol, LDL; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D066275:Health Information Exchange; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008055:Lipids
chemical_list: D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids