title: Receptors, signaling networks, and disease.
abstract: Over the past years, a holistic approach has been applied to the study of the field of receptor signaling, permitting the analysis of how the interaction between receptors and their cellular environment determines receptor function and the study of the role of these receptors, under both normal and pathophysiological conditions, in whole organisms. This has been facilitated by the development of high-resolution microscopy techniques, which allow single-molecule or spatiotemporal resolution, or both, of signaling processes at the cellular and organismal levels. Concurrently, the role of these signaling pathways can be tested in increasingly sophisticated murine disease models. Finally, computational approaches aid in predicting and understanding receptor behavior. The program of the Madrid meeting reflected this integrated approach, highlighting signaling by and dynamics and regulation of immune cell receptors, the T cell receptor and B cell receptor, and signaling by and regulation of G protein-coupled receptors.
authors.affiliation: Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, 28049 Madrid, Spain. ncuesta@cbm.uam.es
authors.forename: Natalia
authors.initials: N
authors.lastname: Cuesta
authors.forename: Noa B
authors.initials: NB
authors.lastname: Martín-Cófreces
authors.forename: Cristina
authors.initials: C
authors.lastname: Murga
authors.forename: Hisse M
authors.initials: HM
authors.lastname: van Santen
mesh_terms: D000818:Animals; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism*; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011948:Receptors, Antigen, T-Cell; D043562:Receptors, G-Protein-Coupled