title: Two new α-pinene derivatives from Angelica sinensis and their anticoagulative activities.
abstract: Two new α-pinene derivatives (1-2) were isolated from the aerial parts of Angelica sinensis. Their structures were determined by spectroscopic and chemical methods to be 6β,9-dihydroxy-(+)-α-pinene (1) and 9-hydroxy-(+)-α-pinene-6β-O-D-glucoside (2). In the anticoagulative assay, compounds 1 and 2 exhibited weak antithrombin activity and strong antiplatelet aggregation activity in vitro.
authors.affiliation: Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors.forename: Nian-Yun
authors.initials: NY
authors.lastname: Yang
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Zhou
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.forename: Sheng
authors.initials: S
authors.lastname: Guo
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.forename: Jin-Ao
authors.initials: JA
authors.lastname: Duan
authors.forename: Bing-Sheng
authors.initials: BS
authors.lastname: Song
authors.forename: Zi-Qing
authors.initials: ZQ
authors.lastname: He
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification*; D000081008:Bicyclic Monoterpenes; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D008297:Male; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification*; D011817:Rabbits
chemical_list: C560508:6beta,9-dihydroxy-(+)alpha-pinene; C560509:9-hydroxy-(+)-alpha-pinene-6beta-O-D-glucoside; D000925:Anticoagulants; D000081008:Bicyclic Monoterpenes; D004365:Drugs, Chinese Herbal; D039821:Monoterpenes; C005451:alpha-pinene