title: Porosity and pore size regulate the degradation product profile of polylactide.
abstract: Porosity and pore size regulated the degradation rate and the release of low molar mass degradation products from porous polylactide (PLA) scaffolds. PLA scaffolds with porosities above 90% and different pore size ranges were subjected to hydrolytic degradation and compared to their solid analog. The solid film degraded fastest and the degradation rate of the porous structures decreased with decreasing pore size. Degradation products were detected earlier from the solid films compared to the porous structures as a result of the additional migration path within the porous structures. An intermediate degradation rate profile was observed when the pore size range was broadened. The morphology of the scaffolds changed during hydrolysis where the larger pore size scaffolds showed sharp pore edges and cavities on the scaffold surface. In the scaffolds with smaller pores, the pore size decreased during degradation and a solid surface was formed on the top of the scaffold. Porosity and pore size, thus, influenced the degradation and the release of degradation products that should be taken into consideration when designing porous scaffolds for tissue engineering.
authors.affiliation: Department of Fibre and Polymer Technology, Royal Institute of Technology, SE-100 44 Stockholm, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Odelius
authors.forename: Anders
authors.initials: A
authors.lastname: Höglund
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kumar
authors.forename: Minna
authors.initials: M
authors.lastname: Hakkarainen
authors.forename: Anup K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: Naresh
authors.initials: N
authors.lastname: Bhatnagar
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Albertsson
mesh_terms: D002152:Calorimetry, Differential Scanning; D002850:Chromatography, Gel; D008401:Gas Chromatography-Mass Spectrometry; D006868:Hydrolysis; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D052616:Solid Phase Extraction; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D011091:Polyesters; C033616:poly(lactide)