title: The effect of intermittent IL-2 therapy on CD4 T cells in the gut in HIV-1-infected patients.
abstract: We sought to determine the effects of interleukin-2 administered in combination with antiretroviral therapy (ART) on CD4+ T cells in the gut. Lymphocytes from whole blood, colon, and terminal ileum of HIV-infected adults treated with interleukin-2 and ART or ART alone were examined. There were no differences between groups in the proportion of CD4+ T cells or in expression of CD25 or Ki67 by CD4+ T cells in the gut. Although IL-2 administration leads to expansion of peripheral blood CD4+ T cells, there is no alteration in the proportion or activation of CD4+ T cells in the gut mucosa.
authors.affiliation: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. readsa@niaid.nih.gov
authors.forename: Sarah W
authors.initials: SW
authors.lastname: Read
authors.forename: Emily J
authors.initials: EJ
authors.lastname: Ciccone
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Mannon
authors.forename: Michael D
authors.initials: MD
authors.lastname: Yao
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Chairez
authors.forename: Richard T
authors.initials: RT
authors.lastname: Davey
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kovacs
authors.forename: Irini
authors.initials: I
authors.lastname: Sereti
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D018801:CD2 Antigens / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000276:immunology*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use*; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D018801:CD2 Antigens; D007376:Interleukin-2; D019394:Ki-67 Antigen