title: Donor cause of brain death in renal transplantation: a predictive factor for graft function?
abstract: OBJECTIVE
  Our aim was to evaluate the influence of donor cause of brain death on the results of kidney transplantation.
  
  
  METHODS
  This retrospective study included 896 consecutive deceased-donor renal transplantations performed between January 1, 2000, and December 31, 2009. We compared outcomes of grafts from donors after cerebrovascular accident (CVA; n = 371) versus head trauma (HT; n = 525).
  
  
  RESULTS
  Univariate analysis of pretransplantation data showed statistically significant differences (P < .05): among the following variables for the HT versus CVA groups respectively: recipient age (43.63 ± 13.2 y vs 49.80 ± 12.5 y); donor age (36.06 ± 16.6 y vs 52.57 ± 13.2 y) and time on dialysis (50.67 ± 45.034 mo vs 59.39 ± 46.3 mo). Regarding transplantation results, we observed that mean serum creatinine was significantly lower among HT recipient, at 1, 3, 6, 12, and 24 months after transplantation (P < .05). Chronic allograft nephropathy (CAN) and delayed graft function were higher among the CVA group. HT group kidneys showed significantly longer mean survival times than CVA group kidneys (102.7 ± 3.9 mo vs 94.8 ± 5.6 mo; log rank: P = .04). Upon multivariate analysis donor cause of death was not identified as an independent risk factor for graft survival or occurrence of chronic allograft nephropathy.
  
  
  CONCLUSIONS
  Transplantation results were better among the HT group. However multivariate regression analysis indicated that donor cause of death was not an independent risk factor for graft survival or occurrence of chronic allograft nephropathy.
authors.affiliation: Urology and Renal Transplantation Department, Coimbra University Hospital, Coimbra, Portugal. lorenzo_marconi@hotmail.com
authors.forename: L
authors.initials: L
authors.lastname: Marconi
authors.forename: P
authors.initials: P
authors.lastname: Moreira
authors.forename: B
authors.initials: B
authors.lastname: Parada
authors.forename: C
authors.initials: C
authors.lastname: Bastos
authors.forename: A
authors.initials: A
authors.lastname: Roseiro
authors.forename: A
authors.initials: A
authors.lastname: Mota
mesh_terms: D000328:Adult; D000368:Aged; D001926:Brain Death; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies