title: Fine structural study of the regeneration of muscle fibers in the rat soleus muscle during aging.
abstract: We examined the regeneration of muscle fibers in the soleus muscle of mature (12 months) and aged (24 and 27 months) rats by using electron microscopy. In both mature and aged muscles, regenerating muscle fibers were mainly formed within the scaffolds of basal laminae after necrosis. In the aged muscle, however, satellite cells within the scaffolds were occasionally destroyed, and immature muscle cells occurred in and around muscle bundles. These findings suggest that new muscle fibers formed in the interstitial spaces may contribute to the total number of regenerated muscle fibers. The origin of the immature muscle cells is briefly discussed.
authors.affiliation: Department of Integrated Basic Medical Research, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan.
authors.forename: Junzo
authors.initials: J
authors.lastname: Desaki
authors.forename: Naoya
authors.initials: N
authors.lastname: Nishida
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D008854:Microscopy, Electron; D018485:Muscle Fibers, Skeletal / Q000502:physiology* / Q000648:ultrastructure*; D018482:Muscle, Skeletal / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000502:physiology*