title: Optimal timing of delayed free lower abdominal flap breast reconstruction after postmastectomy radiation therapy.
abstract: BACKGROUND
  The purpose of this study was to determine the optimal timing of delayed abdominal free flap breast reconstruction following postmastectomy radiation therapy. The authors evaluated the association between timing of delayed abdominal free flap breast reconstruction following postmastectomy radiation therapy and postoperative complications.
  
  
  METHODS
  The authors reviewed a prospectively maintained database of delayed abdominal free flap breast reconstruction performed between July of 2005 and December of 2009. Data regarding demographics, operative variables, and clinical outcomes were collected. Patients were classified as having undergone reconstruction less than 12 months after postmastectomy radiation therapy (group I) or 12 months or more after postmastectomy radiation therapy (group II). Complications were compared between groups, including microvascular thrombosis, flap loss, reoperation, wound dehiscence, and fat necrosis.
  
  
  RESULTS
  One hundred eighty-nine patients were identified, 82 (43.4 percent) in group I and 107 (56.6 percent) in group II. The total flap loss rate was 2.6 percent, with all flap losses occurring in group I (p = 0.014). The reoperation rate was higher in group I (14.6 percent versus 4.7 percent; p = 0.022). In addition, group I patients trended toward a higher incidence of microvascular thrombosis, infection, and wound dehiscence.
  
  
  CONCLUSIONS
  Patients who underwent delayed abdominal free flap breast reconstruction after 12 months from the completion of postmastectomy radiation therapy developed fewer complications, including microvascular thrombosis and total flap loss, than those who underwent delayed abdominal free flap breast reconstruction within 12 months of completing postmastectomy radiation therapy. Allowing an interval of 12 months between the completion of postmastectomy radiation therapy and delayed abdominal free flap breast reconstruction will likely minimize complications and optimize outcomes in free flap breast reconstruction in patients receiving postmastectomy radiation.
authors.affiliation: Houston, Texas From the Departments of Plastic Surgery and Biostatistics, University of Texas M. D. Anderson Cancer Center.
authors.forename: Donald P
authors.initials: DP
authors.lastname: Baumann
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Crosby
authors.forename: Jesse C
authors.initials: JC
authors.lastname: Selber
authors.forename: Patrick B
authors.initials: PB
authors.lastname: Garvey
authors.forename: Justin M
authors.initials: JM
authors.lastname: Sacks
authors.forename: David M
authors.initials: DM
authors.lastname: Adelman
authors.forename: Mark T
authors.initials: MT
authors.lastname: Villa
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.forename: Geoffrey L
authors.initials: GL
authors.lastname: Robb
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D058752:Free Tissue Flaps; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D008408:Mastectomy; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult