title: Alfuzosin induced thrombocytopenia after treatment for benign prostatic hyperplasia.
abstract: We report on 1 case of alfuzosin induced thrombocytopenia after treatment for benign prostatic hyperplasia. This side effect has been recognized 3 months after the alfuzosin treatment. The diagnosis was made by complete blood count (CBC). Peripheral blood smear of the patient was referred to an hematologist to exclude pseudothrombocytopenia and review of the peripheral smear confirmed the decreased platelets with no clumping. Manual count of platelets was similar to the result of complete blood count. After cessation of alfuzosin treatment thrombocytopenia improved and thrombocyte count reached to normal on week 2 following the discontinuation of treatment. Recovery of thrombocytopenia after discontinuation of alfuzosin treatment and recurrent depletion of platelet count after initiation of alfuzosin, supports our thoughts about drug-induced thrombocytopenia (DITP) caused by alfuzosin. The patient was prescribed different alfa blocker and he faced no problem.
authors.affiliation: Istanbul Training and Research Hospital, Department of Hematology, Istanbul, Turkey.
authors.forename: Sebnem
authors.initials: S
authors.lastname: Güner
authors.forename: Bircan
authors.initials: B
authors.lastname: Mutlu
authors.forename: Ekrem
authors.initials: E
authors.lastname: Güner
authors.forename: Ali Ihsan
authors.initials: AI
authors.lastname: Taşçi
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000009:adverse effects*; D000368:Aged; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D011799:Quinazolines / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D011799:Quinazolines; C047638:alfuzosin