title: Design and synthesis of benzoylphenylureas with fluorinated substituents on the aniline ring as insect growth regulators.
abstract: Enormous numbers of synthetic fluorine-containing compounds have been widely used in a variety of fields, especially in drug and pesticide design. To find novel insect growth regulators, a series of benzoylphenylureas with fluorinated substituents were designed and synthesized. The results of larvicidal activities of those novel fluoro-substituted benzoylphenylureas against oriental armyworm and mosquito revealed that most compounds exhibited excellent activities. It is worth mentioning that compounds 3 and 6 exhibited higher activities against oriental armyworm and mosquito than commercial Hexaflumuron. It can be further seen that the insecticidal activities would increase significantly by introducing fluorinated substituents into the structure of the designed benzoylphenylureas.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Ranfeng
authors.initials: R
authors.lastname: Sun
authors.forename: Yuxiu
authors.initials: Y
authors.lastname: Liu
authors.forename: Yonglin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lixia
authors.initials: L
authors.lastname: Xiong
authors.forename: Qingmin
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000818:Animals; D003465:Culex / Q000187:drug effects / Q000254:growth & development; D015195:Drug Design; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007605:Juvenile Hormones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects / Q000254:growth & development; D010671:Phenylurea Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D007306:Insecticides; D007605:Juvenile Hormones; D010671:Phenylurea Compounds