title: Blood pressure in relation to concentrations of PCB congeners and chlorinated pesticides.
abstract: BACKGROUND
  Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed.
  
  
  OBJECTIVE
  The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB groups with common actions or structure, 35 individual PCB congeners, and nine chlorinated pesticides.
  
  
  METHODS
  Linear regression analysis was used to determine the relationships between blood pressure and serum levels of the various contaminants after adjustment for age, body mass index, sex, race, smoking, and exercise in 394 Anniston residents who were not taking antihypertensive medication.
  
  
  RESULTS
  Other than age, total serum PCB concentration was the strongest determinant of blood pressure of the covariates studied. We found the strongest associations for those PCB congeners that had multiple ortho chlorines. We found the associations over the full range of blood pressure as well as in those subjects whose blood pressure was in the normal range. The chlorinated pesticides showed no consistent relationship to blood pressure.
  
  
  CONCLUSIONS
  In this cross-sectional study, serum concentrations of PCBs, especially those congeners with multiple ortho chlorines, were strongly associated with both systolic and diastolic blood pressure.
authors.affiliation: Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, New York, USA.
authors.forename: Alexey
authors.initials: A
authors.lastname: Goncharov
authors.forename: Marian
authors.initials: M
authors.lastname: Pavuk
authors.forename: Herman R
authors.initials: HR
authors.lastname: Foushee
authors.forename: David O
authors.initials: DO
authors.lastname: Carpenter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects*; D017606:Chlorine Compounds / Q000097:blood* / Q000633:toxicity; D003430:Cross-Sectional Studies; D004785:Environmental Pollutants / Q000097:blood* / Q000633:toxicity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010575:Pesticides / Q000097:blood* / Q000633:toxicity; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000633:toxicity; D055815:Young Adult
chemical_list: D017606:Chlorine Compounds; D004785:Environmental Pollutants; D010575:Pesticides; D011078:Polychlorinated Biphenyls