title: Giant prolactinoma causing cranio-cervical junction instability: a case report.
abstract: Prolactinomas are common secretory pituitary tumours, usually managed with dopamine agonists. There have previously been case reports of rarer giant prolactinomas causing invasion of surrounding structures. We describe a case report of an exceptionally aggressive giant prolactinoma that eroded the occipital condyles causing cranio-cervical joint instability mandating surgical fixation.
authors.affiliation: Department of Neurosurgery, Wessex Neurological Centre, Southampton University Hospitals NHS Trust, Southampton SO16 6YD, UK.
authors.forename: Malik J A
authors.initials: MJ
authors.lastname: Zaben
authors.forename: Stuart E
authors.initials: SE
authors.lastname: Harrisson
authors.forename: N V
authors.initials: NV
authors.lastname: Mathad
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001174:Arthrodesis; D000077465:Cabergoline; D002574:Cervical Vertebrae / Q000473:pathology; D003388:Cranial Fossa, Posterior / Q000473:pathology; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000534:rehabilitation; D003399:Craniotomy; D004873:Ergolines / Q000627:therapeutic use; D006801:Humans; D006966:Hyperprolactinemia; D007593:Joint Instability / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D009361:Neoplasm Invasiveness; D009777:Occipital Bone / Q000473:pathology; D009989:Orthotic Devices; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D015175:Prolactinoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D020127:Recovery of Function; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D004873:Ergolines; D000077465:Cabergoline