title: [Expression of serum sHLA-G in patients with hemophagocytic syndrome and its clinical significance].
abstract: In order to investigate the expression of serum sHLA-G in hemophagocytic syndrome (HPS) patients and to evaluate its clinical significance, the clinical data of HPS patients in Capital Medical University Beijing Friendship Hospital during the period from September 2008 to July 2010 were collected. They were divided into infection-associated HPS, tumor-associated HPS and rheumatological disease-associated HPS according to cause of diseases. The serum concentration of sHLA-G in HPS patients and 25 healthy controls was measured by enzyme-linked immunosorbent assay (ELISA), the correlations between sHLA-G level and laboratory indicators were analyzed. The results showed that the level of serum sHLA-G in HPS patients was significantly higher than that in healthy controls (p = 0.003), but the difference was not statistically significant between HPS groups of different causes (p = 0.233). The positive correlation of sHLA-G level in HPS patients with platelet count was found, but there was no positive correlation of their sHLA-G levels with WBC, Hb, Plt, ALT, AST, LDH, Alb, TBil, DBil, IBil, Cr, BUN, TG, fibrinogen and ferritin levels detected on same day. It is concluded that the the increase of serum sHLA-G levels in HPS patients may be caused by different factors such as infection, tumor, T cell activation and over-stimulation of several cytokines. sHLA-G can inhibit NK cell activity, resulting in formation of abnormal immune storm, and may be play a role in the pathogenesis of HPS.
authors.affiliation: Department of Hematology, Capital Medical University, Beijing 100050, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Wang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: Lin
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
authors.forename: Dao-Xiang
authors.initials: DX
authors.lastname: Wu
authors.forename: Nuan
authors.initials: N
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D059951:HLA-G Antigens / Q000097:blood*; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism; D051359:Lymphohistiocytosis, Hemophagocytic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D059951:HLA-G Antigens