title: Population-based mammography screening below age 50: balancing radiation-induced vs prevented breast cancer deaths.
abstract: BACKGROUND
  Exposure to ionizing radiation at mammography screening may cause breast cancer. Because the radiation risk increases with lower exposure age, advancing the lower age limit may affect the balance between screening benefits and risks. The present study explores the benefit-risk ratio of screening before age 50.
  
  
  METHODS
  The benefits of biennial mammography screening, starting at various ages between 40 and 50, and continuing up to age 74 were examined using micro-simulation. In contrast with previous studies that commonly used excess relative risk models, we assessed the radiation risks using the latest BEIR-VII excess absolute rate exposure-risk model.
  
  
  RESULTS
  The estimated radiation risk is lower than previously assessed. At a mean glandular dose of 1.3 mGy per view that was recently measured in the Netherlands, biennial mammography screening between age 50 and 74 was predicted to induce 1.6 breast cancer deaths per 100,000 women aged 0-100 (range 1.3-6.3 extra deaths at a glandular dose of 1-5 mGy per view), against 1121 avoided deaths in this population. Advancing the lower age limit for screening to include women aged 40-74 was predicted to induce 3.7 breast cancer deaths per 100,000 women aged 0-100 (range 2.9-14.4) at biennial screening, but would also prevent 1302 deaths.
  
  
  CONCLUSIONS
  The benefits of mammography screening between age 40 and 74 were predicted to outweigh the radiation risks.
authors.affiliation: Erasmus MC, Department of Public Health, P.O. box 2040, 3000 CA, Rotterdam, The Netherlands. r.degelder@erasmusmc.nl
authors.forename: R
authors.initials: R
authors.lastname: de Gelder
authors.forename: G
authors.initials: G
authors.lastname: Draisma
authors.forename: E A M
authors.initials: EA
authors.lastname: Heijnsdijk
authors.forename: H J
authors.initials: HJ
authors.lastname: de Koning
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000209:etiology* / Q000401:mortality; D005260:Female; D006801:Humans; D008327:Mammography / Q000009:adverse effects*; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011829:Radiation Dosage