title: Adenovirus-mediated drug-sensitivity gene therapy for hepatocellular carcinoma.
abstract: Selective gene therapy represents a potent approach in cancer treatment that utilizes a cell's own nontoxic suicide genes. Currently, the suicide genes under investigation mediate sensitivity by encoding viral or bacterial enzymes that convert inactive prodrug into toxic antimetabolites that inhibit nucleic acid synthesis (1,2).
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA.
authors.forename: F
authors.initials: F
authors.lastname: Kanai
authors.forename: M
authors.initials: M
authors.lastname: Ohashi
authors.forename: P A
authors.initials: PA
authors.lastname: Marignani
authors.forename: Y
authors.initials: Y
authors.lastname: Shiratori
authors.forename: H
authors.initials: H
authors.lastname: Hamada
authors.forename: M
authors.initials: M
authors.lastname: Omata