title: Will nanotechnology influence targeted cancer therapy?
abstract: The rapid development of techniques that enable synthesis (and manipulation) of matter on the nanometer scale and the development of new nanomaterials will play a large role in disease diagnosis and treatment, specifically in targeted cancer therapy. Targeted nanocarriers are an intriguing means to selectively deliver high concentrations of cytotoxic agents or imaging labels directly to the cancer site. Often, solubility issues and an unfavorable biodistribution can result in a suboptimal response of novel agents even though they are very potent. New nanoparticulate formulations allow simultaneous imaging and therapy ("theranostics"), which can provide a realistic means for the clinical implementation of such otherwise suboptimal formulations. In this review, we did not attempt to provide a complete overview of the rapidly enlarging field of nanotechnology in cancer; rather, we presented properties specific to nanoparticles and examples of their uses, which show their importance for targeted cancer therapy.
authors.affiliation: Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Jan
authors.initials: J
authors.lastname: Grimm
authors.forename: David A
authors.initials: DA
authors.lastname: Scheinberg
mesh_terms: D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy*