title: Hemagglutinating virus of Japan liposome-mediated gene delivery to vascular cells.
abstract: Since the first report of in vivo direct gene transfer to the vessel wall in 1990 (1) several vectors, such as adenovirus, liposomes, and adeno-associated virus have been employed to introduce foreign genes to the vascular tissue in vivo. Hemagglutinating virus of Japan (HVJ, Sendai virus), a member of the mouse paramyxovirus family, has been combined with liposomes to produce a novel gene transfer system, namely, HVJ liposomes (2,3). This vector system is constructed with inactivated viral particles and nonviral lamellar liposomes, and is defined as a "viral, nonviral hybrid vector." We and others have shown that this vector system can introduce foreign genes into the vascular tissue efficiently (4-9), and have also demonstrated that these genes and synthetic oligodeoxynucleotides (ODNs) transferred by this system could add some functions to the vessel wall (4-6) or prevent the vascular proliferative diseases (7-9).
authors.affiliation: Transport Unit, National Heart and Lung Institute, London, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Yonemitsu
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneda