title: Management of Fournier's gangrene: experience of a university hospital of Curitiba.
abstract: OBJECTIVE
  To analyze the results obtained in the Department of General Surgery, Cajuru University Hospital-PUCPR, with the treatment of Fournier's gangrene.
  
  
  METHODS
  We reviewed the charts of 40 patients diagnosed with Fournier's gangrene admitted to the Cajuru University Hospital from November 1999 to April 2006, analyzing gender, age, predisposing factors, etiology, lesion location, laboratory tests, surgical procedures, antibiotic use and hyperbaric oxygen therapy.
  
  
  RESULTS
  The most common etiology was the anorectal origin. The most prevalent etiological agent was E. coli. The predominant predisposing factor was diabetes mellitus. The majority of patients were male. The location and extent of injury was usually in the perineum. All underwent surgical debridement, 17 with associated colostomy and two with combined cystostomy. All patients received antibiotics, the most used being metronidazole and gentamicin. Twenty-six patients underwent hyperbaric therapy. The overall mortality was 20%.
  
  
  CONCLUSIONS
  Fournier's syndrome, despite all the advances in treatment today, continues to show high mortality rates. Early recognition of infection associated with invasive and aggressive treatment are essential for attempting to reduce these prognostic indices.
authors.affiliation: Hospital Universitário Cajuru, PUCPR, Curitiba, Paraná, Brazil.
authors.forename: Adriano Antonio
authors.initials: AA
authors.lastname: Mehl
authors.forename: Dorivam Celso
authors.initials: DC
authors.lastname: Nogueira Filho
authors.forename: Lucas Marques
authors.initials: LM
authors.lastname: Mantovani
authors.forename: Michele Mamprim
authors.initials: MM
authors.lastname: Grippa
authors.forename: Ralf
authors.initials: R
authors.lastname: Berger
authors.forename: Denise
authors.initials: D
authors.lastname: Krauss
authors.forename: Denise
authors.initials: D
authors.lastname: Ribas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil; D005260:Female; D018934:Fournier Gangrene / Q000601:surgery*; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult