title: Association of plasma aldosterone with the metabolic syndrome in two German populations.
abstract: OBJECTIVE
  The aim of this study was to analyze the potential association of the plasma aldosterone concentration (PAC) with the metabolic syndrome (MetS) and its components in two German population-based studies.
  
  
  METHODS
  We selected 2830 and 2901 participants (31-80 years) from the follow-ups of the Study of Health in Pomerania (SHIP)-1 and the Cooperative Health Research in the Region of Augsburg (KORA) F4 respectively. MetS was defined as the presence of at least three out of the following five criteria: waist circumference ≥94 cm (men (m)) and ≥80 cm (women (w)); high-density lipoprotein (HDL) cholesterol <1.0 mmol/l (m) and <1.3 mmol/l (w); blood pressure ≥130/85 mmHg or antihypertensive treatment; non-fasting glucose (SHIP-1) ≥8 mmol/l, fasting glucose (KORA F4) ≥5.55 mmol/l or antidiabetic treatment; non-fasting triglycerides (SHIP-1) ≥2.3 mmol/l, fasting triglycerides (KORA F4) ≥1.7 mmol/l, or lipid-lowering treatment. We calculated logistic regression models by comparing the highest study- and sex-specific PAC quintiles versus all lower quintiles.
  
  
  RESULTS
  MetS was common with 48.1% (m) and 34.8% (w) in SHIP-1 and 42.7% (m) and 27.5% (w) in KORA F4. Our logistic regression models revealed associations of PAC with MetS, elevated triglycerides, and decreased HDL cholesterol in SHIP-1 and KORA F4.
  
  
  CONCLUSIONS
  Our findings add to the increasing evidence supporting a relation between aldosterone and MetS and suggest that aldosterone may be involved in the pathophysiology of MetS and lipid metabolism disorders.
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Ferdinand-Sauerbruch-Strasse, Greifswald, Germany. anke.hannemann@uni-greifswald.de
authors.forename: Anke
authors.initials: A
authors.lastname: Hannemann
authors.forename: Christa
authors.initials: C
authors.lastname: Meisinger
authors.forename: Martin
authors.initials: M
authors.lastname: Bidlingmaier
authors.forename: Angela
authors.initials: A
authors.lastname: Döring
authors.forename: Barbara
authors.initials: B
authors.lastname: Thorand
authors.forename: Margit
authors.initials: M
authors.lastname: Heier
authors.forename: Petra
authors.initials: P
authors.lastname: Belcredi
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Ladwig
authors.forename: Henri
authors.initials: H
authors.lastname: Wallaschofski
authors.forename: Nele
authors.initials: N
authors.lastname: Friedrich
authors.forename: Sabine
authors.initials: S
authors.lastname: Schipf
authors.forename: Jan
authors.initials: J
authors.lastname: Lüdemann
authors.forename: Rainer
authors.initials: R
authors.lastname: Rettig
authors.forename: Jörg
authors.initials: J
authors.lastname: Peters
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
authors.forename: Jochen
authors.initials: J
authors.lastname: Seissler
authors.forename: Felix
authors.initials: F
authors.lastname: Beuschlein
authors.forename: Matthias
authors.initials: M
authors.lastname: Nauck
authors.forename: Martin
authors.initials: M
authors.lastname: Reincke
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000450:Aldosterone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006306:Health Surveys / Q000379:methods; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods
chemical_list: D015415:Biomarkers; D000450:Aldosterone