title: [Preparation and in vitro drug release of ferulic acid loaded chitosan microspheres containing liposomes].
abstract: OBJECTIVE
  To construct the ferulic acid loaded chitosan microspheres containing liposomes.
  
  
  METHODS
  Ferulic acid was selected to be the model drug. Liposomes were prepared by calcium acetate gradient method. The entrapment efficiency of liposomes was(79.97 +/- 0.54)%, the average size was (187.6 +/- 11.9) nm and the Zeta potential was -12.67 +/-1.78. The chitosan microspheres, whose entrapment efficiency was (57.89 +/- 1.72)%, were prepared by onic gelation method after liposomes were mixed with chiotosan solution. Ferulic acid was entrapped in liposomes in amorphous form and then liposomes were distributed in microspheres intactly.
  
  
  RESULTS
  The 80.97% liposomes were released from microspheres and the 32.33% ferulic acid was released from microspheres at 12 h, which was much slower than simple chitosan microspheres.
  
  
  CONCLUSIONS
  This study demonstrated that chitosan microspheres containing liposomes have good sustained-releasing property in vitro.
authors.affiliation: College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
authors.forename: Jifen
authors.initials: J
authors.lastname: Zhang
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Lan
authors.initials: L
authors.lastname: Jia
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Xu
mesh_terms: D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D004339:Drug Compounding; D007700:Kinetics; D008081:Liposomes / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size
chemical_list: D003373:Coumaric Acids; D003692:Delayed-Action Preparations; D008081:Liposomes; D048271:Chitosan; C004999:ferulic acid