title: Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi.
abstract: We report on a scrub typhus patient who contracted meningoencephalitis during doxycycline administration. This is the first case of scrub typhus in which doxycycline concentrations were measured in serum and cerebrospinal fluid. Clinicians should be alerted to the possibility that meningoencephalitis can occur because of inadequate maintenance of serum doxycycline level caused by antacids administered along with doxycycline.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, and Research Center for Resistant Cells, Chosun University College of Medicine, Gwangju, Republic of Korea.
authors.forename: Dong-Min
authors.initials: DM
authors.lastname: Kim
authors.forename: Yoon Seong
authors.initials: YS
authors.lastname: Kim
authors.forename: Hea-Young
authors.initials: HY
authors.lastname: Cho
authors.forename: Yong-Bok
authors.initials: YB
authors.lastname: Lee
mesh_terms: D000368:Aged; D000536:Aluminum Hydroxide / Q000009:adverse effects / Q000627:therapeutic use*; D000863:Antacids / Q000009:adverse effects / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002254:Carbonates / Q000009:adverse effects / Q000627:therapeutic use*; D004318:Doxycycline / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D006801:Humans; D008276:Magnesium Hydroxide / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008590:Meningoencephalitis / Q000188:drug therapy / Q000382:microbiology*; D012285:Orientia tsutsugamushi; D012612:Scrub Typhus / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000863:Antacids; D000900:Anti-Bacterial Agents; D002254:Carbonates; C043698:almagate; D000536:Aluminum Hydroxide; D004318:Doxycycline; D008276:Magnesium Hydroxide