title: Acute effect of phosphodiesterase type 5 inhibitor on serum oxidative status and prolidase activities in men with erectile dysfunction.
abstract: OBJECTIVE
  To investigate the acute effect of phosphodiesterase type 5 (PDE5) inhibitor on erectile dysfunction by evaluating serum oxidative status and prolidase activity.
  
  
  METHODS
  Serum samples of 36 patients with erectile dysfunction and 30 control cases were analyzed for total antioxidant status, total oxidant status, and prolidase activity, before and after the administration of tadalafil citrate.
  
  
  RESULTS
  Before and after tadalafil citrate administration, serum total antioxidant status, total oxidant status, and prolidase were 1.1+0.0 vs. 1.6 + 0.0 umol H₂O₂ Eq/L, 10.3+1.1 vs. 6.9 + 1.2 umol H₂O₂ Eq/L, and 236.4+19.5 vs. 228.2 + 19.2 U/L, respectively (p < 0.0001 for all).
  
  
  CONCLUSIONS
  Evaluation of serum oxidative status and prolidase activity confirmed the beneficial acute effects of PDE5 inhibitor in patients with erectile dysfunction.
authors.affiliation: Department of Urology, School of Medicine, Harran University, Sanliurfa, Turkey. mrtsvs@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Savas
authors.forename: Ercan
authors.initials: E
authors.lastname: Yeni
authors.forename: Ayhan
authors.initials: A
authors.lastname: Verit
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gulum
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.forename: Halil
authors.initials: H
authors.lastname: Ciftci
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Adem
authors.initials: A
authors.lastname: Altunkol
authors.forename: Halil
authors.initials: H
authors.lastname: Oncel
mesh_terms: D000328:Adult; D002243:Carbolines / Q000494:pharmacology*; D016022:Case-Control Studies; D004150:Dipeptidases / Q000378:metabolism*; D007172:Erectile Dysfunction / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D058986:Phosphodiesterase 5 Inhibitors / Q000494:pharmacology*; D000068581:Tadalafil
chemical_list: D002243:Carbolines; D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil; D004150:Dipeptidases; C022454:prolyl dipeptidase