title: [Efficacy and tolerability of pantogam activ in patients with partial epilepsy].
abstract: Randomized double-blind, placebo-controlled study to determine efficacy and tolerability of pantogam activ as an add-on drug in patients with partial epilepsy was conducted. 20 patients received pantogam activ, 20 patients - placebo. Good tolerability and no advers event were detected in the dose of 1800 mg/d. The reduction in the frequency of epileptic seizures was achieved in 72,1% in the group receiving pantogam activ and in 16,7% in the group placebo. Significant improvement in long-term memory and manifestations of anxiety were found in patients using pantogam activ. Quality of life in scale QOLIE-31 improved after taking pantogam and did not change after placebo.
authors.forename: I E
authors.initials: IE
authors.lastname: Poverennova
authors.forename: A V
authors.initials: AV
authors.lastname: Iakunina
authors.forename: V A
authors.initials: VA
authors.lastname: Kalinin
authors.forename: N N
authors.initials: NN
authors.lastname: Savel'eva
mesh_terms: D000328:Adult; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018697:Nootropic Agents / Q000627:therapeutic use*; D010205:Pantothenic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010919:Placebos / Q000008:administration & dosage / Q000627:therapeutic use; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D018697:Nootropic Agents; D010919:Placebos; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid