title: Genetics of mechanosensation in the heart.
abstract: Mechanosensation (the ultimate conversion of a mechanical stimulus into a biochemical signal) as well as mechanotransduction (transmission of mechanically induced signals) belong to the most fundamental processes in biology. These effects, because of their dynamic nature, are particularly important for the cardiovascular system. Therefore, it is not surprising that defects in cardiac mechanosensation, are associated with various types of cardiomyopathy and heart failure. However, our current knowledge regarding the genetic basis of impaired mechanosensation in the cardiovascular system is beginning to shed light on this subject and is at the centre of this brief review.
authors.affiliation: Myocardial Genetics, British Heart Foundation-Centre for Research Excellence, National Heart & Lung Institute, Imperial College, South Kensington Campus, London, UK. r.knoell@imperial.ac.uk
authors.forename: Byambajav
authors.initials: B
authors.lastname: Buyandelger
authors.forename: Keat-Eng
authors.initials: KE
authors.lastname: Ng
authors.forename: Snjezana
authors.initials: S
authors.lastname: Miocic
authors.forename: Sylvia
authors.initials: S
authors.lastname: Gunkel
authors.forename: Izabela
authors.initials: I
authors.lastname: Piotrowska
authors.forename: Ching-Hsin
authors.initials: CH
authors.lastname: Ku
authors.forename: Ralph
authors.initials: R
authors.lastname: Knöll
mesh_terms: D000804:Angiotensin II / Q000235:genetics; D000818:Animals; D009202:Cardiomyopathies / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D064211:Connectin; D006333:Heart Failure / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007382:Intermediate Filaments / Q000378:metabolism; D040542:Mechanotransduction, Cellular / Q000235:genetics*; D009124:Muscle Proteins / Q000235:genetics; D009154:Mutation; D009206:Myocardium / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011494:Protein Kinases / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics; D012518:Sarcomeres / Q000378:metabolism; D012677:Sensation / Q000235:genetics*; D013314:Stress, Mechanical
chemical_list: D064211:Connectin; D009124:Muscle Proteins; C577285:TTN protein, human; D000804:Angiotensin II; D011494:Protein Kinases