title: Sweet and umami taste: natural products, their chemosensory targets, and beyond.
abstract: Much of our appreciation of food is due to the excitement of the perception of "sweet" and "umami" taste. With a special focus on natural products, this Review gives a summary of compounds that elicit and modulate "sweet" or "umami" taste responses. It will be discussed how the interaction of these molecules with the oral sweet and umami taste receptors stimulates receptor cells to secrete neurotransmitters to induce neural activity that is conveyed to the cerebral cortex to represent sweet and umami taste, respectively. Recent data also show that a sweet taste is metabolically relevant for fuel homeostasis and linked to appetitive ingestive behavior.
authors.affiliation: Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
authors.forename: Maik
authors.initials: M
authors.lastname: Behrens
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Meyerhof
authors.forename: Caroline
authors.initials: C
authors.lastname: Hellfritsch
authors.forename: Thomas
authors.initials: T
authors.lastname: Hofmann
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism; D012970:Sodium Glutamate / Q000737:chemistry; D013549:Sweetening Agents / Q000737:chemistry*; D013649:Taste; D013650:Taste Buds / Q000502:physiology; D000098706:Taste Receptors, Type 2
chemical_list: D001688:Biological Products; D043562:Receptors, G-Protein-Coupled; D013549:Sweetening Agents; C431926:taste receptors, type 1; D000098706:Taste Receptors, Type 2; D012970:Sodium Glutamate