title: Preoperative methods to improve erythropoiesis.
abstract: Preoperative anemia creates a challenge for surgical treatment and patient outcomes after major surgery. Prior to a surgical intervention, it is optimal to increase erythropoiesis to improve oxygen transport through the bloodstream for patients at high risk of anemia and to avoid the complications of allogeneic blood transfusion. In this way, patients could receive predeposited autologous blood or, during the surgical procedures, undergo acute normovolemic hemodilution. This approach is allowed by the use of recombinant human erythropoietin in association with erythropoiesis-inducing factors such as iron and folic acid. In this article, we discuss the recent clinical evidences.
authors.affiliation: Department of Anaesthesia and Palliative Care, Azienda Ospedaliero-Universitaria, Fondazione Macchi, Varese, Italy. alessandro.bacuzzi@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Bacuzzi
authors.forename: G
authors.initials: G
authors.lastname: Dionigi
authors.forename: G
authors.initials: G
authors.lastname: Piffaretti
authors.forename: M
authors.initials: M
authors.lastname: Tozzi
authors.forename: M
authors.initials: M
authors.lastname: Del Romano
authors.forename: L
authors.initials: L
authors.lastname: Guzzetti
authors.forename: F
authors.initials: F
authors.lastname: Paracchini
authors.forename: F
authors.initials: F
authors.lastname: Villa
authors.forename: S
authors.initials: S
authors.lastname: Cuffari
mesh_terms: D001803:Blood Transfusion; D000068817:Epoetin Alfa; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D011300:Preoperative Care; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin; D000068817:Epoetin Alfa; D005492:Folic Acid