title: Palliative therapy for osteosarcoma.
abstract: Despite advances in diagnostic imaging, the evolution of neoadjuvant chemotherapy and the refinements in limb-salvage surgery, the progression-free survival rate remains poor for patients with metastatic, recurrent or unresectable osteosarcoma. Different therapeutic strategies for these subgroups of patients have been employed to control disease and prolong survival. Treatment options are limited and controversial, including systemic and localized therapies. Surgical resection, whenever feasible, is still the standard treatment in advanced osteosarcoma. The role of chemotherapy is unclear while the use of radiotherapy, embolization and thermal ablation is increasing. New therapeutic experimental approaches and novel target therapies are needed to improve the outcome of these subgroups of patients.
authors.affiliation: Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, via Pupilli n1, cap 40136 Bologna, Italy.
authors.forename: Costantino
authors.initials: C
authors.lastname: Errani
authors.forename: Alessandra
authors.initials: A
authors.lastname: Longhi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rossi
authors.forename: Eugenio
authors.initials: E
authors.lastname: Rimondi
authors.forename: Alessio
authors.initials: A
authors.lastname: Biazzo
authors.forename: Angelo
authors.initials: A
authors.lastname: Toscano
authors.forename: Nikolin
authors.initials: N
authors.lastname: Alì
authors.forename: Pietro
authors.initials: P
authors.lastname: Ruggieri
authors.forename: Marco
authors.initials: M
authors.lastname: Alberghini
authors.forename: Piero
authors.initials: P
authors.lastname: Picci
authors.forename: Gaetano
authors.initials: G
authors.lastname: Bacci
authors.forename: Mario
authors.initials: M
authors.lastname: Mercuri
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D023821:Limb Salvage; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000628:therapy; D008297:Male; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D012516:Osteosarcoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery / Q000628:therapy*; D010166:Palliative Care
chemical_list: D000970:Antineoplastic Agents