title: Enantioselective organocatalytic Michael-Wittig-Michael-Michael reaction: dichotomous construction of pentasubstituted cyclopentanecarbaldehydes and pentasubstituted cyclohexanecarbaldehydes.
abstract: Michael addition of carbethoxymethylenetriphenylphosphorane (a Wittig reagent) to nitroalkenes, followed by a reaction with ethyl formylformate and cinnamaldehydes, or formaldehyde and cinnamaldehydes, provided the respective pentasubstituted cyclopentanecarbaldehydes bearing a quaternary carbon center and pentasubstituted cyclohexanecarbaldehydes having five contiguous stereocenters with excellent enantioselectivities (up to >99% ee).
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, ROC. chebch@ccu.edu.tw
authors.forename: Bor-Cherng
authors.initials: BC
authors.lastname: Hong
authors.forename: Roshan Y
authors.initials: RY
authors.lastname: Nimje
authors.forename: Cheng-Wei
authors.initials: CW
authors.lastname: Lin
authors.forename: Ju-Hsiou
authors.initials: JH
authors.lastname: Liao