title: Serological response to trivalent inactive influenza vaccine in HIV-infected children with different immunologic status.
abstract: Influenza vaccination is usually recommended for HIV-infected children. One hundred and twenty seven HIV-infected and twenty-one HIV-uninfected children aged ≥6 months to <18 years, all of whom were naïve to influenza vaccine, were enrolled to receive an influenza Trivalent Inactivated Vaccine (TIV). In the HIV group, the post-vaccination immune response (geometric mean titer, seroconversion and seroprotection rates) correlated with their immunological status before vaccination. The HIV-infected children with no immunosuppression had comparable serological response to HIV-uninfected children. For moderately and severely immunosuppressed HIV groups, two doses of TIV resulted in greater serological responses and should be recommended in these groups.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand. pkosalaraksa@yahoo.com
authors.forename: Pope
authors.initials: P
authors.lastname: Kosalaraksa
authors.forename: Ussanee
authors.initials: U
authors.lastname: Srirompotong
authors.forename: Robert W
authors.initials: RW
authors.lastname: Newman
authors.forename: Pagakrong
authors.initials: P
authors.lastname: Lumbiganon
authors.forename: John M
authors.initials: JM
authors.lastname: Wood
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007115:Immunization Schedule; D007223:Infant; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D012367:RNA, Viral / Q000097:blood; D013785:Thailand; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D012367:RNA, Viral; D015164:Vaccines, Inactivated