title: Mobilization and collection of peripheral blood stem cells in multiple myeloma patients older than 65 years.
abstract: Over the past 10 years, the incidence of multiple myeloma (MM) has been greater among individuals >65 years old than in younger age groups. This retrospective study of peripheral blood stem cell mobilization and harvesting examined patients of various age groups who were afflicted with this pathology. One group of 17 patients ≥65 years of age with MM (group A) were mobilized between 2002 and 2009 and compared with 33 consecutive patients of younger ages with the same diagnosis treated in 2008 and 2009 (group B). The 2 populations had a similar gender distribution; their median ages were 66 and 52 years, respectively. A successful mobilization was defined as a collection of ≥2.5 × 10(6) CD34+/kg body weight. The mobilization used filgrastim (16 μg/kg/d) with the beginning of the harvest on the fifth day. The median number of outpatient apheresis procedures per patient was 2 in group A and 1 in group B. There were no incidents or serious adverse reactions. Patients in group A collected 4.68 × 10(6) CD34+ cells/kg and for group B 3.30 × 10(6)/kg. The group A patients required a greater number of apheresis procedures to collect the appropriate graft. In conclusion, mobilization with growth factors and PHSP harvest by apheresis was safe with reasonable costs for subjects including those aged ≥65 years, resulting in an option for autologous transplantation.
authors.affiliation: Serviço de Terapia Celular, Departamento de Imuno-Hemoterapia, IPO Porto, Porto, Portugal.
authors.forename: S
authors.initials: S
authors.lastname: Roncon
authors.forename: I L
authors.initials: IL
authors.lastname: Barbosa
authors.forename: F
authors.initials: F
authors.lastname: Campilho
authors.forename: S M
authors.initials: SM
authors.lastname: Lopes
authors.forename: A
authors.initials: A
authors.lastname: Campos
authors.forename: A
authors.initials: A
authors.lastname: Carvalhais
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000276:immunology; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000601:surgery*; D011994:Recombinant Proteins; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning
chemical_list: D018952:Antigens, CD34; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim