title: Moyamoya disease as a possible cause of neurological impairment following liver transplantation for Wilson's disease.
abstract: In Wilson's disease, liver transplantation can constitute the only option for patients presenting with fulminant hepatic failure or decompensated liver disease unresponsive to drug therapy. We report the case of a 29-year-old woman receiving a liver transplant for end-stage Wilson's disease who developed neurological complications after transplantation. After an accurate evaluation of possible differential causes of neurological complications developing as the result of liver transplantation, moyamoya disease was diagnosed. Moyamoya disease is a rare cerebrovascular disease of unknown etiology. However, data exist supporting a possible role for some immunosuppressive regimens in determining the peculiar vascular alterations observed in moyamoya disease. To the best of our knowledge, the association with post-transplantation state for Wilson's disease has not been previously described.
authors.affiliation: Digestive and Liver Disease Department, S. Andrea Hospital, II Medical School, University "Sapienza", Rome, Italy Departments of Vascular and Interventional Radiology Faculty of Medicine and Health Sciences, Hepatology and Gastroenterology Neurology, Laboratory for Clinical and Experimental Neurophysiology, Ghent University, Ghent, Belgium.
authors.forename: Federico
authors.initials: F
authors.lastname: Desideri
authors.forename: Massimo
authors.initials: M
authors.lastname: Marignani
authors.forename: Olivier
authors.initials: O
authors.lastname: Vanovermeire
authors.forename: Isabelle
authors.initials: I
authors.lastname: Colle
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Delle Fave
authors.forename: Dimitri
authors.initials: D
authors.lastname: Hemelsoet
authors.forename: Anja
authors.initials: A
authors.lastname: Geerts
authors.forename: Hans
authors.initials: H
authors.lastname: Van Vlierberghe