title: Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly.
abstract: Diastereoselective chain-elongation reactions are important transformations for the assembly of complex molecular structures, such as those present in polyketide natural products. Here we report new methods for performing crotylation reactions and homopropargylation reactions by using newly developed low-temperature flow-chemistry technology. In-line purification protocols are described, as well as the application of the crotylation protocol in an automated multi-step sequence.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Catherine F
authors.initials: CF
authors.lastname: Carter
authors.forename: Heiko
authors.initials: H
authors.lastname: Lange
authors.forename: Daiki
authors.initials: D
authors.lastname: Sakai
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley