title: Evolutionary history of Dengue virus type 4: insights into genotype phylodynamics.
abstract: Dengue virus type 4 (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 isolates sampled from 37 countries during the time period 1956-2008 and the spreading dynamics for genotypes I and II. The region (tropical rainforest biome) comprised by Malaysia-Thailand was the most likely ancestral area from which the serotype has originated and spread. Interestingly, cross-correlation analysis on demographic time series with the Asian sequences showed a statistically significant negative correlation that could be suggestive of competition among genotypes within the same serotype.
authors.affiliation: Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, CEP 05508-000, Av Prof Lineu Prestes, 1734 São Paulo, Brazil.
authors.forename: Christian Julián
authors.initials: CJ
authors.lastname: Villabona-Arenas
authors.forename: Paolo Marinho de Andrade
authors.initials: PM
authors.lastname: Zanotto
mesh_terms: D000569:Americas / Q000453:epidemiology; D001208:Asia / Q000453:epidemiology; D005075:Biological Evolution; D003710:Demography; D003715:Dengue / Q000453:epidemiology / Q000821:virology*; D003716:Dengue Virus / Q000145:classification* / Q000235:genetics*; D005838:Genotype; D006801:Humans; D013997:Time Factors