title: A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.
abstract: Semi-synthetic analogues of β-boswellic acid (BA) and 11-keto-β-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the triterpenes were observed to have significant cytotoxicity against both the cells, displaying cytotoxicity in HL-60 cells at low concentrations. Further investigations suggested the proapoptotic potential associated with the two molecules to induce cytotoxicity in HL-60 cells, where one of them showed early proapoptotic effect as evidenced by several biological end-points of the apoptosis such as annexinV binding, DNA fragmentation and increase in sub-G0 DNA fraction and apoptotic bodies formation (Hoechst 33258 staining and SEM studies).
authors.affiliation: Indian Institute of Integrative Medicine, CSIR, Canal Road, Jammu Tawi 180001, India.
authors.forename: Rajbir
authors.initials: R
authors.lastname: Kaur
authors.forename: Sheema
authors.initials: S
authors.lastname: Khan
authors.forename: Renu
authors.initials: R
authors.lastname: Chib
authors.forename: Tandeep
authors.initials: T
authors.lastname: Kaur
authors.forename: Parduman Raj
authors.initials: PR
authors.lastname: Sharma
authors.forename: Jaswant
authors.initials: J
authors.lastname: Singh
authors.forename: Bhahwal Ali
authors.initials: BA
authors.lastname: Shah
authors.forename: Subhash Chandra
authors.initials: SC
authors.lastname: Taneja
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D009570:Nitriles / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C447943:11-keto-boswellic acid; D000970:Antineoplastic Agents; D009570:Nitriles; D014315:Triterpenes; C054625:boswellic acid; D010100:Oxygen