title: [Protective effects of compound tianpupian against oxidative damage in mouse erythrocytes].
abstract: The aim of this study was to investigate the protective effects of compound tianpupian (TPP) and its compositions against oxidative damage in mouse erythrocytes. The protective effect of TPP and its compositions against the red cell hemolysis induced by (2)O(2) or auto-oxidation were observed by scanning electron microscopy and spectrophotomety. The result indicated that compound TPP and all of its four components including extract of Rhodiola sachalinensis, Grape Seed Extract proanthocyanidins, Acanthopanax senticosus extract, and tea polyphenols had significant inhibitory activities for the oxidative damage of mouse erythrocytes, out of which the Grape seed extract proanthocyanidins showed the maximal protective effect. It is concluded that compound TPP can protect erythrocytes against oxidative stress and can be used as a valuable Chinese traditional medicine.
authors.affiliation: Institute of Aviation Medicine of Chinese Air Force, Beijing 100142, China.
authors.forename: Yong-Xin
authors.initials: YX
authors.lastname: Wang
authors.forename: Ri-Bao
authors.initials: RB
authors.lastname: Wei
authors.forename: Zhe
authors.initials: Z
authors.lastname: Feng
authors.forename: Shao-Yuan
authors.initials: SY
authors.lastname: Cui
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D056604:Grape Seed Extract / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D044945:Proanthocyanidins / Q000494:pharmacology; D029771:Rhodiola
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D056604:Grape Seed Extract; C511402:Grape Seed Proanthocyanidins; D044945:Proanthocyanidins