title: A multi-functional synthetic gene network: a frequency multiplier, oscillator and switch.
abstract: We present the design and analysis of a synthetic gene network that performs frequency multiplication. It takes oscillatory transcription factor concentrations, such as those produced from the currently available genetic oscillators, as an input, and produces oscillations with half the input frequency as an output. Analysis of the bifurcation structure also reveals novel, programmable multi-functionality; in addition to functioning as a frequency multiplier, the network is able to function as a switch or an oscillator, depending on the temporal nature of the input. Multi-functionality is often observed in neuronal networks, where it is suggested to allow for the efficient coordination of different responses. This network represents a significant theoretical addition that extends the capabilities of synthetic gene networks.
authors.affiliation: Department of Engineering Mathematics, Bristol Centre for Complexity Sciences, University of Bristol, Bristol, United Kingdom. enoep@bristol.ac.uk
authors.forename: Oliver
authors.initials: O
authors.lastname: Purcell
authors.forename: Mario
authors.initials: M
authors.lastname: di Bernardo
authors.forename: Claire S
authors.initials: CS
authors.lastname: Grierson
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Savery
mesh_terms: D001683:Biological Clocks / Q000235:genetics*; D003198:Computer Simulation; D005787:Gene Frequency / Q000235:genetics; D053263:Gene Regulatory Networks / Q000502:physiology*; D005812:Genes, Switch / Q000502:physiology*; D005813:Genes, Synthetic / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D009994:Osmolar Concentration; D012107:Research Design; D013269:Stochastic Processes; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology
chemical_list: D014157:Transcription Factors