title: Voltage-sensing phosphatase: its molecular relationship with PTEN.
abstract: Voltage-sensing phosphoinositide phosphatase (VSP) contains voltage sensor and cytoplasmic phosphatase domains. A unique feature of this protein is that depolarization-induced motions of the voltage sensor activate PtdIns(3,4,5)P(3) and PtdIns(4,5)P(2) phosphatase activities. VSP exhibits remarkable structural similarities with PTEN, the phosphatase and tensin homolog deleted on chromosome 10. These similarities include the cytoplasmic phosphatase region, the phosphoinositide binding region, and the putative membrane interacting C2 domain.
authors.affiliation: Department of Physiology, Graduate School of Medicine, Osaka University, Osaka, Japan. yokamura@phys2.med.osaka-u.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okamura
authors.forename: Jack E
authors.initials: JE
authors.lastname: Dixon
mesh_terms: D000818:Animals; D006801:Humans; D008958:Models, Molecular; D051059:PTEN Phosphohydrolase / Q000737:chemistry* / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry* / Q000378:metabolism; D017434:Protein Structure, Tertiary
chemical_list: D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human