title: The epidemiology of gastroenteropancreatic neuroendocrine tumors.
abstract: In this article, updated analyses of the National Cancer Institute Surveillance, Epidemiology and End Results (SEER) registry (1973-2007) are presented and compared with epidemiologic GEP-NET data from Europe and Asia. Several studies have demonstrated a steadily increasing incidence of GEP-NETs, and this escalation is still ongoing (SEER data 2004-2007). The common primary GEP-NET sites exhibit unique epidemiologic profiles with distinct patterns of incidence, age at diagnosis, stage, and survival. Overall, GEP-NET survival has improved over the past 3 decades, although the outcome for poorly differentiated tumors remains dismal.
authors.affiliation: Gastrointestinal Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, 310 Cedar Street, PO Box 208602, New Haven, CT 06520-8062, USA.
authors.forename: Ben
authors.initials: B
authors.lastname: Lawrence
authors.forename: Bjorn I
authors.initials: BI
authors.lastname: Gustafsson
authors.forename: Anthony
authors.initials: A
authors.lastname: Chan
authors.forename: Bernhard
authors.initials: B
authors.lastname: Svejda
authors.forename: Mark
authors.initials: M
authors.lastname: Kidd
authors.forename: Irvin M
authors.initials: IM
authors.lastname: Modlin
mesh_terms: D005770:Gastrointestinal Neoplasms / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D015994:Incidence; D018358:Neuroendocrine Tumors / Q000453:epidemiology* / Q000401:mortality; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000401:mortality; D018426:SEER Program; D013997:Time Factors; D014481:United States / Q000453:epidemiology