title: Molecular Analysis in Factor XI Deficiency.
abstract: Factor XI (FXI) is the zymogen precursor of an active serine protease that participates in the contact phase of coagulation. Synthesized in the liver, it circulates in the plasma in a noncovalent complex with high molecular weight kininogen (1) at a normal concentration of 5 μg/mL. (For clinical purposes, the normal range is defined as 50-150 U/dL) (2). FXI circulates as a homodimeric glycoprotein with a mass of 160 kDa.
authors.affiliation: Haemostasis Research Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: K M
authors.initials: KM
authors.lastname: Johnson
authors.forename: J H
authors.initials: JH
authors.lastname: McVey