title: Lymphocyte-predominant Hodgkin disease: a comprehensive overview.
abstract: Lymphocyte-predominant Hodgkin disease is a rare form of Hodgkin lymphoma that is recognized as a separate histopathological entity. This disease tends to have multiple relapses, but has an overall good prognosis. Owing to its rarity, and the prolonged time period between recurrence and transformation events, there is no consensus regarding optimal management. However, the National Comprehensive Cancer Network guidelines indicate that for early stages, appropriate treatment is radiotherapy. Several management options have been reported including observation, radiation, chemotherapy, combined chemoradiotherapy, and anti-CD20 antibody therapy. Salvage therapy remains effective in inducing prolonged remission in patients with relapsed/refractory disease.
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, George Washington University, Washington, DC, USA.
authors.forename: Sumit
authors.initials: S
authors.lastname: Bose
authors.forename: Chitra
authors.initials: C
authors.lastname: Ganesan
authors.forename: Manish
authors.initials: M
authors.lastname: Pant
authors.forename: Catherine
authors.initials: C
authors.lastname: Lai
authors.forename: Imad A
authors.initials: IA
authors.lastname: Tabbara
mesh_terms: D059248:Chemoradiotherapy; D006689:Hodgkin Disease / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D016879:Salvage Therapy