title: Milk and growth in children: effects of whey and casein.
abstract: Consumption of cow's milk is recommended in many countries. Observational and intervention studies show that cow's milk most likely has a positive influence on growth in children. The strongest evidence comes from observational studies and intervention studies in low-income countries, but there are also observational studies from high-income countries showing positive associations between milk intake and growth. Milk seems thus to have a specific stimulating effect on linear growth, not only in developing countries with high rates of malnutrition, but also in industrialized countries. However, it is not known which components in milk stimulate growth. Possible components are proteins, minerals, vitamins or combinations of these. Cow's milk proteins have a high protein quality, and whey has a slightly higher quality than casein, according to some indices based on amino acid composition. Studies, mainly from sport medicine, have suggested that whey protein also has the potential to increase muscle mass. Whether whey improves body composition to a larger extent than other milk proteins is not clear. The mechanism behind a possible growth-stimulating effect of milk and milk components is likely to be through a stimulation of insulin-like growth factor-I synthesis and maybe insulin secretion. In conclusion, there is strong evidence that milk stimulates linear growth. The mechanism is not yet clear, and more intervention studies are needed to understand which components in milk are responsible for the growth stimulation. The effects of milk on linear growth and adult height may have both positive and negative long-term implications.
authors.affiliation: Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Mølgaard
authors.forename: Anni
authors.initials: A
authors.lastname: Larnkjær
authors.forename: Karina
authors.initials: K
authors.lastname: Arnberg
authors.forename: Kim F
authors.initials: KF
authors.lastname: Michaelsen
mesh_terms: D000818:Animals; D001827:Body Height / Q000187:drug effects / Q000502:physiology*; D002364:Caseins / Q000008:administration & dosage* / Q000494:pharmacology; D002648:Child; D002657:Child Development / Q000187:drug effects* / Q000502:physiology; D002675:Child, Preschool; D019049:Developed Countries; D003906:Developing Countries; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008892:Milk / Q000009:adverse effects / Q000378:metabolism; D008894:Milk Proteins / Q000008:administration & dosage* / Q000494:pharmacology; D009753:Nutritive Value; D000067816:Whey Proteins
chemical_list: D002364:Caseins; D007328:Insulin; D008894:Milk Proteins; D000067816:Whey Proteins; D007334:Insulin-Like Growth Factor I