title: [Influence of suoquan capsule on detrusor of D-galactose mimetic rats].
abstract: OBJECTIVE
  To discuss the influence of Suoquan capsule (SQJN) on the detrusor of D-galactose mimetic rats, and to explore the mechanism of reducing urine.
  
  
  METHODS
  Investigate the enzymes (ATPase, SDH, SOD, MDA, Na+ -K+ -ATPase, Ca2+ - Mg2+ -ATPase) which influence the production and excretion of urine and the reactivity of urinary detrusor strips to different concentrations of ISO and ATP.
  
  
  RESULTS
  Compared with the model group, the activity of SOD, Na+ -K+ -ATPase, Ca2+ -Mg2+ -ATPase and SDH increased significantly in aging rats after administrating SQJN (P < 0.01); the complaisance and elasticity of bladder also increased (P < 0.05). The frequency of spontaneous contraction and the MDA decreased significantly (P < 0.05-0.01). The decreased relaxation response to ISO and increased contractile response to ATP were also changed after administrating SQJN.
  
  
  CONCLUSIONS
  SQJN can regulate the metabolism of fluid through recovering the normal physiologic function of the detrusor of bladder.
authors.affiliation: Yunnan Institute of Materia Medica, Kunming 650111, China. ty1203@163.com
authors.forename: Ying
authors.initials: Y
authors.lastname: Tan
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Hongying
authors.initials: H
authors.lastname: Cao
authors.forename: Meng
authors.initials: M
authors.lastname: Shi
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D005690:Galactose / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology; D051381:Rats; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D053202:Urinary Incontinence, Urge / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D014554:Urination / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D005690:Galactose