title: Molecular targeting of breast cancer: imaging and therapy.
abstract: Breast cancer is increasing at an alarming rate in women around the world, where medical biology is confronted by this disease on two crucial fronts. The first step is the early accurate diagnosis, which is very critical and the second step involves the appropriate clinical management. The current trend in molecular imaging of breast cancer provides not only an excellent tool in diagnosing the disease but also useful in validating the potentiality targeted of a pharmaceutical interventions. This review addresses the effectiveness of imaging technologies to resolve the molecular characterization and pathological evidences in breast cancer. The focus is on the present practices in breast cancer imaging, specifically targeting cellular machineries such as hormone receptors and angiogenic factors.
authors.affiliation: Translational Molecular Imaging Group, Laboratory of Molecular Imaging, Singapore BioImaging Consortium, A*STAR, 11 biopolis way, 01-02 Helios, Singapore. Padmanabhan@sbic.a-star.edu.sg
authors.forename: Parasuraman
authors.initials: P
authors.lastname: Padmanabhan
authors.forename: Julian
authors.initials: J
authors.lastname: Goggi
authors.forename: Romain
authors.initials: R
authors.lastname: Bejot
authors.forename: Kishore K
authors.initials: KK
authors.lastname: Bhakoo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D011956:Receptors, Cell Surface / Q000096:biosynthesis; D011960:Receptors, Estrogen / Q000096:biosynthesis; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000970:Antineoplastic Agents; D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen