title: Emerging role for ERM proteins in cell adhesion and migration.
abstract: The highly related ERM (Ezrin, Radixin, Moesin) proteins provide a regulated linkage between the membrane and the underlying actin cytoskeleton. They also provide a platform for the transmission of signals in responses to extracellular cues. Studies in different model organisms and in cultured cells have highlighted the importance of ERM proteins in the generation and maintenance of specific domains of the plasma membrane. A central question is how do ERM proteins coordinate actin filament organization and membrane protein transport/stability with signal transduction pathways to build up complex structures? Through their interaction with numerous partners including membrane proteins, actin cytoskeleton and signaling molecules, ERM proteins have the ability to organize multiprotein complexes in specific cellular compartments. Likewise, ERM proteins participate in diverse functions including cell morphogenesis, endocytosis/exocytosis, adhesion and migration. This review focuses on aspects still poorly understood related to the function of ERM proteins in epithelial cell adhesion and migration.
authors.affiliation: UMR 144, Centre National de la Recherche Scientifique/Morphogenèse et Signalisation Cellulaires, Institut Curie, Paris, France. marpin@curie.fr
authors.forename: Monique
authors.initials: M
authors.lastname: Arpin
authors.forename: Dafne
authors.initials: D
authors.lastname: Chirivino
authors.forename: Alexandra
authors.initials: A
authors.lastname: Naba
authors.forename: Ingrid
authors.initials: I
authors.lastname: Zwaenepoel
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D017173:Caenorhabditis elegans; D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D004331:Drosophila melanogaster; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D054730:Protein Interaction Domains and Motifs; D015398:Signal Transduction; D000099149:Ezrin
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D000099149:Ezrin; C071058:moesin; C071776:radixin