title: Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France.
abstract: Seventeen Klebsiella pneumoniae isolates producing the OXA-48 carbapenemase, obtained from 10 patients hospitalized from April to June 2010, mostly in the medical intensive care unit of the Villeneuve-Saint-Georges Hospital in a suburb of Paris, France, were analyzed. Seven patients were infected, of whom five were treated at least with a carbapenem, and five patients died. Molecular analysis showed that the isolates belonged to a single clone that harbored a 70-kb plasmid carrying the blaOXA-48 gene and coproduced CTX-M-15 and TEM-1 β-lactamases. This is the first reported outbreak of OXA-48-producing K. pneumoniae isolates in France.
authors.affiliation: Service de Bactériologie-Virologie, INSERM U914, Hôpital de Bicêtre, 78 Rue du Général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: Gaelle
authors.initials: G
authors.lastname: Cuzon
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Ouanich
authors.forename: Remy
authors.initials: R
authors.lastname: Gondret
authors.forename: Thierry
authors.initials: T
authors.lastname: Naas
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D015780:Carbapenems / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005602:France; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology* / Q000472:pathogenicity; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D015780:Carbapenems; D001618:beta-Lactamases; C108449:oxacillinase