title: [Study of patients with cleft lip and palate with consanguineous parents].
abstract: Cleft lip and/or palate (CL/P) are the most common congenital anomalies of the face. CL/P are non-syndromic (CL/PNS) in about 70% of subjects.
  
  
  OBJECTIVE
  To describe clinical cases of non-syndromic CL/P (CL/PNS) associated with consanguinity, diagnosed at a reference hospital in Minas Gerais, Brazil, and to correlate these alterations with possible risk factors. SERIES AND METHODS: A retrospective study at a reference hospital for craniofacial deformities in Minas Gerais, Brazil from 2006 to 2009 based on data in medical records.
  
  
  RESULTS
  Of 246 CL/PNS cases diagnosed and treated at the institution, 15 (6.1%) were CL/PNS with reported first-degree consanguinity; 73.3% occurred in males. Four of 15 patients had complete right cleft palate and lip (CLP), 4 presented complete cleft palate and lip (right and left), 3 had complete unilateral left CLP, 3 had isolated cleft palate, and 1 presented cleft lip only. Among the risk factors, only three mothers reported smoking during pregnancy.
  
  
  CONCLUSIONS
  CLP (unilateral or bilateral) were more frequent in the group with a history of first-degree consanguinity; males predominated. Among the risk factors, only smoking was observed in three cases.
authors.affiliation: Estomatopatologia pela Universidade Estadual de Campinas - Unicamp, Brasil.
authors.forename: Sibele Nascimento de
authors.initials: SN
authors.lastname: Aquino
authors.forename: Lívia Máris Ribeiro
authors.initials: LM
authors.lastname: Paranaíba
authors.forename: Daniella Reis Barbosa
authors.initials: DR
authors.lastname: Martelli
authors.forename: Mário Sérgio Oliveira
authors.initials: MS
authors.lastname: Swerts
authors.forename: Letízia Monteiro de
authors.initials: LM
authors.lastname: Barros
authors.forename: Paulo Rogério Ferreti
authors.initials: PR
authors.lastname: Bonan
authors.forename: Hercílio
authors.initials: H
authors.lastname: Martelli Júnior
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D002648:Child; D002971:Cleft Lip / Q000209:etiology / Q000235:genetics*; D002972:Cleft Palate / Q000209:etiology / Q000235:genetics*; D003241:Consanguinity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects