title: [Bioactivity diversity and functional mechanism of tetrahydroisoquinoline alkaloids].
abstract: Tetrahydroisoquinoline alkaloids distributed widely in the nature and some have a broad application in clinic. More attention has been paid in recent years on this type of alkaloid, owing to the diverse range of biological activities exhibited by these alkaloids and the discovery of new functional mechanisms and molecular targets underlying these activities. This article summarized the recent advances in the biological activities and functional mechanism of tetrahydroisoquinoline, which included the activities such as antitumor, antibiotic, antivirus, anti-inflammatory, anticoagulation, bronchodilation, and the action on central nervous system, with the purpose of providing some ideas in the study of biological activity of this type of alkaloid and in the search for lead-compound and rational drug design.
authors.affiliation: School of Pharmacy, Shandong University, Jinan 250012, China.
authors.forename: Ce-Jia
authors.initials: CJ
authors.lastname: Liu
authors.forename: Dian-Yu
authors.initials: DY
authors.lastname: Liu
authors.forename: Lan
authors.initials: L
authors.lastname: Xiang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000494:pharmacology; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001993:Bronchodilator Agents; D002491:Central Nervous System Agents; D005343:Fibrinolytic Agents; D018696:Neuroprotective Agents; D044005:Tetrahydroisoquinolines