title: Subcutaneous infection of methicillin resistant Staphylococcus aureus (MRSA).
abstract: MRSA is a worldwide threat to public health, and MRSA skin and soft-tissue infections now account for more than half of all soft-tissue infections in the United States. Among soft-tissue infections, myositis, pyomyositis, and necrotizing fasciitis have been increasingly reported in association with MRSA arising from the community. To understand the interplay between MRSA and host immunity leading to more severe infection, the availability of animal models is critical, permitting the study of host and bacterial factors. Several infection models have been introduced to assess the pathogenesis of S. aureus during superficial skin infection. Here, we describe a subcutaneous infection model that examines the skin, subcutaneous, and muscle pathologies.
authors.affiliation: Department of Pediatrics, Cedars-Sinai Medical Center, USA. tsengcw@cshs.org
authors.forename: Ching Wen
authors.initials: CW
authors.lastname: Tseng
authors.forename: Marisel
authors.initials: M
authors.lastname: Sanchez-Martinez
authors.forename: Andrea
authors.initials: A
authors.lastname: Arruda
authors.forename: George Y
authors.initials: GY
authors.lastname: Liu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D055624:Methicillin-Resistant Staphylococcus aureus / Q000276:immunology / Q000472:pathogenicity*; D051379:Mice; D013203:Staphylococcal Infections / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D013207:Staphylococcal Skin Infections / Q000276:immunology / Q000382:microbiology* / Q000473:pathology