title: [Efficacy of sweat-antigen-inactivating skin care products on itching of patients with atopic dermatitis].
abstract: BACKGROUND
  Many patients with atopic dermatitis showed immediate-type hypersensitivity against sweat antigen. Therefore, to deal with sweating is important to prevent itching and aggravations of dermatitis of patient with atopic dermatitis. We had searched a substance that inactivated sweat antigen adopting histamine release test. And we found that tannic acid which selected by screening various natural products inactivated sweat antigen.
  
  
  METHODS
  We evaluate skin care products (spray, after-bathing water and aerosol-spray) containing tannic acid for patients with atopic dermatitis. We administered in a tannic acid-containing spray and after-bathing water on 17 patients with atopic dermatitis.
  
  
  RESULTS
  After treatment, total clinical assessment score and itching in the afternoon had significantly decreased from that on day 0. To evaluate the effect of tannic acid containing-aerosol spray on itching of patients with AD, we assessed symptoms of atopic dermatitis patients who used a tannic acid containing-aerosol spray every day for 4 weeks in a cross-over, double-blind study. Clinical severity of atopic dermatitis and degrees of itching in daily life of patients were evaluated by physicians and patients themselves, respectively. Degrees of itching in morning and those at night were significantly more largely improved by the use of tannic acid-containing aerosol spray than those by the use of placebo control aerosol spray. The overall efficacy of tannic acid-containing aerosol sprays was also significantly higher than those of tannic acid free spray.
  
  
  CONCLUSIONS
  Sweat antigen inactivating skin care products may be effective to reduce itching of patients with atopic dermatitis.
authors.affiliation: Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University, Japan. shindoh@hiroshima-u.ac.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Shindo
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Takahagi
authors.forename: Shoji
authors.initials: S
authors.lastname: Mihara
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Tanaka
authors.forename: Kaori
authors.initials: K
authors.lastname: Ishii
authors.forename: Michihiro
authors.initials: M
authors.lastname: Hide
authors.forename: Shigeru
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Kanatani
authors.forename: Shingo
authors.initials: S
authors.lastname: Yano
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000941:Antigens; D018592:Cross-Over Studies; D003876:Dermatitis, Atopic / Q000150:complications / Q000188:drug therapy*; D004304:Dosage Forms; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D017592:Skin Care; D013542:Sweat / Q000276:immunology; D013634:Tannins / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000336:Aerosols; D000941:Antigens; D004304:Dosage Forms; D013634:Tannins