title: Mutations in ribosomal proteins and ribosomal RNA confer macrolide resistance in human Ureaplasma spp.
abstract: Genetic mechanisms of macrolide resistance were investigated in six isolates of Ureaplasma spp. with erythromycin minimum inhibitory concentrations (MICs)≥ 8 μg/mL that were derived from 370 cultures obtained over a several year period. Point mutations in domain V of 23S rRNA and/or mutations in ribosomal protein L4 genes are likely to be responsible for this drug resistance. Overall, macrolide resistance was uncommon, in contrast to tetracycline resistance that was documented in 121 unique isolates (33%).
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Xiao
authors.forename: Donna M
authors.initials: DM
authors.lastname: Crabb
authors.forename: Lynn B
authors.initials: LB
authors.lastname: Duffy
authors.forename: Vanya
authors.initials: V
authors.lastname: Paralanov
authors.forename: John I
authors.initials: JI
authors.lastname: Glass
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Hamilos
authors.forename: Ken B
authors.initials: KB
authors.lastname: Waites
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics*; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D017354:Point Mutation; D012335:RNA, Ribosomal / Q000235:genetics*; D012269:Ribosomal Proteins / Q000235:genetics*; D014509:Ureaplasma / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D012335:RNA, Ribosomal; D012269:Ribosomal Proteins