title: [Study on pharmacokinetics of phillyrin in Shuanghuanglian for injection].
abstract: OBJECTIVE
  To study the plasma concentration and pharmacokinetics of phillyrin in Shuanghuanglian for injection in rats.
  
  
  METHODS
  SD rats were given Shuanghuanglian for injection by iv, blood samples were collected at different time. The phillyrin concentration in plasma was determined by RP-HPLC. The parameters of pharmacokinetics were analyzed by program DAS 2.0.
  
  
  RESULTS
  The main pharmacokinetics parameters of phillyrin in rats:t1/2 (alpha) (0.44 +/- 0.06) h, t1/2 (beta) (2.77 +/- 0.36) h, V1 (0.09 +/- 0.01) L/kg, CL (0.09 +/- 0.007) L/(h x kg), AUC0-1, (5.56 +/- 0.47 mg x h/L), AUC0-infinity (6.44 +/- 0.53) mg x h/L.
  
  
  CONCLUSIONS
  Phillyrin has two compartment model in rats, the pharmacokinetics of phillyrin characteristic is a process of rapid dispatching and slow elimination in rats.
authors.affiliation: School of Traditional Chinese Medicine of Guangdong Pharmaceutical University, Guangzhou 510006, China. zengfanlin-honglan@126.com
authors.forename: Fan-Lin
authors.initials: FL
authors.lastname: Zeng
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Shen
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D031657:Forsythia / Q000737:chemistry*; D005960:Glucosides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007267:Injections; D008297:Male; D023421:Models, Animal; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005960:Glucosides; C516400:shuang-huang-lian; C075528:phillyrin