title: Bench-to-bedside review: the role of C1-esterase inhibitor in sepsis and other critical illnesses.
abstract: The purpose of this bench-to-bedside review is to summarize the literature relating to complement activation in sepsis and other critical illnesses and the role of C1-esterase inhibitor (C1 INH) as a potential therapy.
authors.affiliation: Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK. m.singer@ucl.ac.uk
authors.forename: Mervyn
authors.initials: M
authors.lastname: Singer
authors.forename: Annie M
authors.initials: AM
authors.lastname: Jones
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D050718:Complement C1 Inhibitor Protein / Q000502:physiology / Q000627:therapeutic use*; D003171:Complement Pathway, Classical / Q000276:immunology; D016638:Critical Illness / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D019095:Point-of-Care Systems / Q000639:trends; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D050718:Complement C1 Inhibitor Protein