title: Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei.
abstract: Two unprecedented cyclic peptides, solomonamides A and B, were isolated from the marine sponge Theonella swinhoei. The structures were elucidated on the basis of comprehensive 1D and 2D NMR analysis and high-resolution mass spectrometry. A combined approach, involving Marfey's method, QM J based analysis, and DFT J/(13)C calculations, was used for establishing the absolute configuration of the entire molecule. Solomonamide A showed in vivo anti-inflammatory activity.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Carmen
authors.initials: C
authors.lastname: Festa
authors.forename: Simona
authors.initials: S
authors.lastname: De Marino
authors.forename: Valentina
authors.initials: V
authors.lastname: Sepe
authors.forename: Maria Valeria
authors.initials: MV
authors.lastname: D'Auria
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bifulco
authors.forename: Cecile
authors.initials: C
authors.lastname: Débitus
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: Bucci
authors.forename: Valentina
authors.initials: V
authors.lastname: Vellecco
authors.forename: Angela
authors.initials: A
authors.lastname: Zampella
mesh_terms: D000409:Alanine / Q000737:chemistry; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012694:Serine / Q000737:chemistry; D047232:Theonella / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010456:Peptides, Cyclic; C558620:solomonamide A; C558621:solomonamide B; D012694:Serine; D000409:Alanine