title: Effect of Aloe vera gel extract on antioxidant enzymes and azoxymethane-induced oxidative stress in rats.
abstract: The present work was undertaken with a view to study the effect of oral feeding of 2% Aloe vera gel extract (AGE) for 30 days on azoxymethane (AOM)-induced oxidative stress in rats. It was observed that AOM administration resulted in a significant increase in malondialdehyde and conjugated dienes, with reduction in hepatic glutathione (GSH), vitamin A and uric acid contents. AOM-induced reduction in hepatic GSH and uric acid was brought back to normal by AGE. There was a significant raise in hepatic catalase, superoxide dismutase and glucose-6-phosphate dehydrogenase (G-6-PD) activities as a result of feeding of the extract. Ingestion of the extract effected reduction in AOM-induced colonic GSH-peroxidase, G-6-PD and glutathione S-transferase and femur bone marrow micronuclei formation. Hence, it is suggested that Aloe vera gel extract possess the ability to reduce AOM- induced oxidative stress and toxicity in liver.
authors.affiliation: Biochemistry & Nutrition Discipline, Defence Food Research Laboratory, Mysore 570011, India. anilakumarkr@gmail.com
authors.forename: K R
authors.initials: KR
authors.lastname: Anilakumar
authors.forename: K R
authors.initials: KR
authors.lastname: Sudarshanakrishna
authors.forename: G
authors.initials: G
authors.lastname: Chandramohan
authors.forename: N
authors.initials: N
authors.lastname: Ilaiyaraja
authors.forename: Farhath
authors.initials: F
authors.lastname: Khanum
authors.forename: A S
authors.initials: AS
authors.lastname: Bawa
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001397:Azoxymethane / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D005782:Gels / Q000494:pharmacology*; D005954:Glucosephosphate Dehydrogenase; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005782:Gels; D010936:Plant Extracts; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D001397:Azoxymethane