title: Total skin electron therapy technique for the canine patient.
abstract: Cutaneous epitheliotropic T-cell lymphoma in canine patients is a radiation sensitive tumor but total skin electron therapy is used only rarely. Our purpose was to evaluate dose distribution from a total skin electron therapy technique using 6MeV electron beams. The treatment was comprised of 12 fields, with the dog in lateral recumbency in a stride position at an extended distance from the source. Uniformity, flatness and symmetry were determined for each beam. The composite percent depth dose profile for all beams was measured in solid water phantoms and skin dose was determined on a canine cadaver using thermoluminescent dosimeters. The resulting d(max) of the composite beams was 1mm and dose variation over the skin was 6.8%, with the extremities having the most uneven dose distribution. Dimensions of the fields were adequate to obtain an effective treatment profile for the entire thickness of canine epidermis and the technique was feasible for clinical application. Individual tailoring of the protocol to deal with hot and cold spots may be necessary and set up will likely involve a significant time commitment for the therapy team.
authors.affiliation: Departments of Molecular Biosciences and Radiation Oncology, North Carolina State University, Raleigh, NC 27606, USA.
authors.forename: Kerensa N
authors.initials: KN
authors.lastname: Rechner
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Weeks
authors.forename: Amy F
authors.initials: AF
authors.lastname: Pruitt
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000532:radiotherapy*; D004285:Dogs; D016410:Lymphoma, T-Cell, Cutaneous / Q000532:radiotherapy / Q000662:veterinary*; D011879:Radiotherapy Dosage / Q000662:veterinary; D011882:Radiotherapy, High-Energy / Q000379:methods / Q000662:veterinary*; D014916:Whole-Body Irradiation / Q000379:methods / Q000662:veterinary*