title: Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors.
abstract: A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.
authors.affiliation: Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
authors.forename: Iou-Jiun
authors.initials: IJ
authors.lastname: Kang
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Wang
authors.forename: Tsu-An
authors.initials: TA
authors.lastname: Hsu
authors.forename: Andrew
authors.initials: A
authors.lastname: Yueh
authors.forename: Chung-Chi
authors.initials: CC
authors.lastname: Lee
authors.forename: Yen-Chun
authors.initials: YC
authors.lastname: Lee
authors.forename: Ching-Yin
authors.initials: CY
authors.lastname: Lee
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Chao
authors.forename: Shin-Ru
authors.initials: SR
authors.lastname: Shih
authors.forename: Jyh-Haur
authors.initials: JH
authors.lastname: Chern
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D007510:Isatin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; C013578:isatin beta-thiosemicarbazone; D007510:Isatin