title: Morphologic differences, according to etiology, in pigment epithelial detachments by means of en face optical coherence tomography.
abstract: OBJECTIVE
  To assess morphologic differences in pigment epithelial detachment (PED) with en face optical coherence tomography in central serous chorioretinopathy (CSC) and age-related macular degeneration (AMD).
  
  
  METHODS
  We recruited 30 eyes of 22 patients with PED. Nine eyes had a clinical diagnosis of CSC and 21 had AMD. All patients were assessed with en face optical coherence tomography. Morphologic PED aspects were estimated on C-scans and classified according to shape, inner silhouette, content, wall aspects, wall thickness, and size.
  
  
  RESULTS
  Pigment epithelial detachment shape was predominantly circular (88.8%) in CSC and irregular or with multilobular features in AMD (76.2%). The PED inner silhouette had a smooth aspect (88.9%) in CSC and a slightly granular aspect or granular profile in AMD (100%). Clear PED content was the most characteristic feature of CSC (88.9%) but not of AMD. In CSC, PED morphologic wall aspect was uniform or slightly irregular (100%), while in AMD, it was slightly irregular (52.4%) or irregular (47.6%). Pigment epithelial detachment wall thickness and dimensions were larger in AMD than in CSC. Statistically significant differences were observed between CSC and AMD concerning PED inner silhouette, contents, wall aspects, and wall thickness measurements.
  
  
  CONCLUSIONS
  En face optical coherence tomography scanning is a valuable tool for showing important morphologic differences between CSC and AMD.
authors.affiliation: Mediterranean Ophthalmology Center, Rome, Italy. bruno.lumbroso@gmail.com
authors.forename: Bruno
authors.initials: B
authors.lastname: Lumbroso
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Savastano
authors.forename: Marco
authors.initials: M
authors.lastname: Rispoli
authors.forename: Angelo
authors.initials: A
authors.lastname: Balestrazzi
authors.forename: Alfonso
authors.initials: A
authors.lastname: Savastano
authors.forename: Emilio
authors.initials: E
authors.lastname: Balestrazzi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056833:Central Serous Chorioretinopathy / Q000150:complications*; D004396:Coloring Agents; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008268:Macular Degeneration / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000145:classification / Q000209:etiology* / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D041623:Tomography, Optical Coherence
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green