title: Clinical outcome of ABO-incompatible living unrelated donor kidney transplantation.
abstract: BACKGROUND
  ABO-incompatible living unrelated donor kidney transplantation is an immunologically high-risk procedure, but few reports have been made on the outcomes of these transplants.
  
  
  METHODS
  We analyzed 12 kidney transplants using ABO-incompatible living-unrelated donors performed at our institution between January 1999 and December 2007, focusing on the immunosuppressive protocols, complications and graft survivals.
  
  
  RESULTS
  Patient and graft survival rates were 100%. One patient experienced antibody-mediated rejection and intractable acute cellular rejection, one had antibody-mediated rejection and one had acute cellular rejection, but their grafts survived after intensive immunosuppressive treatment. There were no severe complications among the recipients.
  
  
  CONCLUSIONS
  In ABO-incompatible living unrelated donor kidney transplantation, severe rejections may occur due to ABO incompatibility and poor histocompatibility. Therefore, appropriate desensitization, immunosuppression and recipient care are needed for a successful transplant. Recent significant improvements in outcomes indicate that it has become a viable treatment option, given the lack of available donor organs.
authors.affiliation: Department of Urology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Japan. m9492120@msic.med.osaka-cu.ac.jp
authors.forename: Junji
authors.initials: J
authors.lastname: Uchida
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Machida
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Iwai
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kuwabara
authors.forename: Taro
authors.initials: T
authors.lastname: Iguchi
authors.forename: Toshihide
authors.initials: T
authors.lastname: Naganuma
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kumada
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kawashima
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakatani
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D001706:Biopsy; D001787:Blood Group Incompatibility / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000235:genetics; D005260:Female; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000628:therapy*; D012306:Risk; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000017:ABO Blood-Group System; D007166:Immunosuppressive Agents