title: Hydrophilically stabilized gold nanostars as SERS labels for tissue imaging of the tumor suppressor p63 by immuno-SERS microscopy.
abstract: A biocompatible, seed-mediated synthesis of monodisperse ~60 nm gold nanostars, followed by hydrophilic stabilization with ethylene glycol-modified Raman reporter molecules, is presented. Their application as SERS labels for imaging of the tumor suppressor p63 in prostate biopsies by immuno-SERS microscopy is demonstrated.
authors.affiliation: University of Osnabrück, Department of Physics, Barbarastr. 7, 49069 Osnabrück, Germany.
authors.forename: Max
authors.initials: M
authors.lastname: Schütz
authors.forename: Dennis
authors.initials: D
authors.lastname: Steinigeweg
authors.forename: Mohammad
authors.initials: M
authors.lastname: Salehi
authors.forename: Karsten
authors.initials: K
authors.lastname: Kömpe
authors.forename: Sebastian
authors.initials: S
authors.lastname: Schlücker
mesh_terms: D000906:Antibodies / Q000276:immunology; D019855:Ethylene Glycol / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D016253:Microscopy, Immunoelectron; D057054:Molecular Imaging; D011467:Prostate / Q000473:pathology*; D013059:Spectrum Analysis, Raman; D014157:Transcription Factors / Q000276:immunology / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000276:immunology / Q000378:metabolism*
chemical_list: D000906:Antibodies; C115051:TP63 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D006046:Gold; D019855:Ethylene Glycol