title: Case report of rapidly progressive proliferative verrucous leukoplakia and a proposal for aetiology in mainland China.
abstract: Proliferative verrucous leukoplakia (PVL) is a rare oral leukoplakia and has four features such as chronic proliferation, multiple occurrences, refractoriness to treatment and high rate of malignant transformation. As mentioned above, most PVL cases processed to malignancy over many years, sometimes 20 years. However, this report described a case of rapid progress, which had malignant transformation in a short period. Additionally, the aetiology of PVL was discussed and immunity was proposed as the possible cause.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, PR. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ge
authors.forename: Yun
authors.initials: Y
authors.lastname: Wu
authors.forename: Lan-yan
authors.initials: LY
authors.lastname: Wu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Xie
authors.forename: Xin
authors.initials: X
authors.lastname: Zeng
authors.forename: Mei
authors.initials: M
authors.lastname: Lin
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Zhou
mesh_terms: D018289:Carcinoma, Verrucous / Q000473:pathology* / Q000601:surgery; D002681:China; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D016896:Treatment Outcome