title: Glucokinase-activating sesquinlignans from the rhizomes of Acorus tatarinowii Schott.
abstract: Three novel sesquinlignans, tatanans A (1), B (2), and C (3), have been isolated from the rhizomes of Acorus tatarinowii Schott. Their structures were established by spectroscopic techniques and single-crystal X-ray analysis. Tatanans A-C potently increase GK enzymatic activity with EC(1.5) values in the range of 0.16-1.85 μM. The potent GK activity and unique structural features of tatanans make them promising leads for therapeutic development of antihyperglycemic drugs.
authors.affiliation: The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Beijing 100050, P. R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Ni
authors.forename: Zhu-Fang
authors.initials: ZF
authors.lastname: Shen
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Ying-Hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Tang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: Zhi-You
authors.initials: ZY
authors.lastname: Hao
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D029023:Acorus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005941:Glucokinase / Q000737:chemistry* / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D017705:Lignans; C561065:tatanan A; C561066:tatanan B; C561067:tatanan C; D005941:Glucokinase