title: Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid.
abstract: This study was performed to determine the antinociceptive and anti-inflammatory activities of ethanolic extract of Lafoensia pacari A. St.-Hil. (PEtExt) stem bark and its fractions using various animal models such as acetic acid-induced abdominal writhing, formalin-induced pain and croton oil-induced ear edema tests. The PEtExt inhibited the acetic acid-induced abdominal writhing, reduced the pain reaction time on both phases of the formalin test and decreased the edema in a dose-dependent manner. Pre-treatment with naloxone did not reverse the antinociceptive effect. Only the ethyl acetate fraction showed antinociceptive and anti-inflammatory effects. Our results also showed that this extract contains compounds with analgesic action independent of anti-inflammatory activity.
authors.affiliation: Instituto de Ciências Biológicas-2, Universidade Federal de Goiás, Goiânia, Brazil. nascimentofarma@yahoo.com.br
authors.forename: Marcus Vinícius Mariano
authors.initials: MV
authors.lastname: Nascimento
authors.forename: Pablinny Moreira
authors.initials: PM
authors.lastname: Galdino
authors.forename: Iziara Ferreira
authors.initials: IF
authors.lastname: Florentino
authors.forename: Bruno Leite
authors.initials: BL
authors.lastname: Sampaio
authors.forename: Frederico Argollo
authors.initials: FA
authors.lastname: Vanderlinde
authors.forename: José Realino
authors.initials: JR
authors.lastname: de Paula
authors.forename: Elson Alves
authors.initials: EA
authors.lastname: Costa
mesh_terms: D000085:Acetates / Q000737:chemistry; D019342:Acetic Acid / Q000633:toxicity; D000700:Analgesics / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004610:Ellagic Acid / Q000494:pharmacology*; D029561:Lythraceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000085:Acetates; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D004610:Ellagic Acid; C007650:ethyl acetate; D019342:Acetic Acid