title: The experimental autoimmune encephalomyelitis model for proteomic biomarker studies: from rat to human.
abstract: Multiple sclerosis (MScl) is defined by central nervous system (CNS) inflammation, demyelination and axonal damage. Some of the disease mechanisms are known but the cause of this complex disorder stays an enigma. Experimental autoimmune encephalomyelitis (EAE) is an animal model mimicking many aspects of MScl. This review aims to provide an overview over proteomic biomarker studies in the EAE model emphasizing the translational aspects with respect to MScl in humans.
authors.affiliation: Department of Analytical Biochemistry, Centre for Pharmacy University of Groningen, Groningen, The Netherlands.
authors.forename: Therese
authors.initials: T
authors.lastname: Rosenling
authors.forename: Amos
authors.initials: A
authors.lastname: Attali
authors.forename: Theo M
authors.initials: TM
authors.lastname: Luider
authors.forename: Rainer
authors.initials: R
authors.lastname: Bischoff
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D040901:Proteomics / Q000379:methods*; D051381:Rats; D057170:Translational Research, Biomedical
chemical_list: D015415:Biomarkers