title: Design, synthesis and cytotoxicity of a new series of isoxazolidines derived from substituted chalcones.
abstract: A new series of isomeric isoxazolidin-3-yl-3-phosphonates were synthesised from N-methyl-C-diethoxyphosphorylnitrone and substituted chalcones. The respective isoxazolidin-3-yl-3-phosphonic acids were obtained from phosphonates via dealkylation procedure using trimethylsilyl bromide. Selected phosphonates and their respective phosphonic acids were screened for their cytotoxic activity to HeLa and K562 cells with IC(50) in the 0.1-0.3mM range.
authors.affiliation: Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Łódź, Muszyńskiego 1, 90-151 Łódź, Poland. dorota.piotrowska@umed.lodz.pl
authors.forename: Dorota G
authors.initials: DG
authors.lastname: Piotrowska
authors.forename: Marcin
authors.initials: M
authors.lastname: Cieślak
authors.forename: Karolina
authors.initials: K
authors.lastname: Królewska
authors.forename: Andrzej E
authors.initials: AE
authors.lastname: Wróblewski
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D047188:Chalcones / Q000737:chemistry*; D015195:Drug Design; D006367:HeLa Cells; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D020014:K562 Cells; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D047188:Chalcones; D007555:Isoxazoles; D014867:Water