title: Advancement and prospects of tumor gene therapy.
abstract: Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. Several therapeutic strategies have evolved, including gene-based (tumor suppressor genes, suicide genes, antiangiogenic genes, cytokine and oxidative stress-based genes) and RNA-based (antisense oligonucleotides and RNA interference) approaches. In addition, immune response-based strategies (dendritic cell- and T cell-based therapy) are also under investigation in tumor gene therapy. This review highlights the progress and recent developments in gene delivery systems, therapeutic strategies, and possible clinical directions for gene therapy.
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Qing-Tao
authors.initials: QT
authors.lastname: Wang
authors.forename: He
authors.initials: H
authors.lastname: Liu
authors.forename: Zhen-Zhu
authors.initials: ZZ
authors.lastname: Zhang
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Huang
mesh_terms: D003713:Dendritic Cells / Q000276:immunology*; D018014:Gene Transfer Techniques; D041722:Genes, Transgenic, Suicide; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D034622:RNA Interference