title: Hirsutane sesquiterpenoids from the marine-derived fungus Chondrostereum sp.
abstract: A new hirsutane sesquiterpenoid, hirsutanol E (1), together with the known compounds hirsutanol A (2) and hirsutanol F (3; gloeosteretriol) were obtained from AcOEt extract of the marine fungus Chondrostereum sp., which was isolated from the soft coral Sarcophyton tortuosum. The structures were elucidated mainly on the basis of the NMR, MS, and X-ray single-crystal diffraction data. Hirsutanol A (2) exhibited potent cytotoxic activities against various cancer cell lines.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, P. R. China.
authors.forename: Hou-Jin
authors.initials: HJ
authors.lastname: Li
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Lan
authors.forename: Chi-Keung
authors.initials: CK
authors.lastname: Lam
authors.forename: Fen
authors.initials: F
authors.lastname: Yang
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Zhu
mesh_terms: D000085:Acetates / Q000737:chemistry; D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D037421:Anthozoa; D000970:Antineoplastic Agents / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D059001:Aquatic Organisms / Q000737:chemistry; D045744:Cell Line, Tumor; D045424:Complex Mixtures / Q000032:analysis / Q000737:chemistry; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D012717:Sesquiterpenes / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000085:Acetates; D000970:Antineoplastic Agents; D045424:Complex Mixtures; D012717:Sesquiterpenes; C007650:ethyl acetate