title: Effect of combined treatment of thioperamide with some antiepileptic drugs on methionine-sulfoximine induced convulsions in mice.
abstract: Methionine-sulfoximine (MSO), a convulsant is known to increase the activity of histamine N-methyl transferase. The effect of a selective H3 receptor agonist R- (alpha) methylhistamine (RAMH) and antagonist (thioperamide, THP) and some antiepileptic drugs (gabapentin and sodium valproate) have been evaluated on MSO-induced convulsions in mice. The effect of THP was also evaluated in combination with these antiepileptic drugs. Sodium valproate (300 mg/kg, po) and gabapentin (400 mg/kg, po) offered protection against MSO-induced convulsions as evidenced by a significant prolongation of latency to abnormal dorsoflexion and complete protection against mortality within 6 h of administration. THP (15 mg/kg, ip) alone and in combination with sub-effective doses of gabapentin (75 mg/kg, po) and sodium valproate (75 mg/kg, po) revealed no significant differences from the control group or either drug alone. Hence, the convulsant action of MSO does not appear to be mediated via histaminergic mechanisms.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India. dvohra@jamiahamdard.ac.in
authors.forename: Divya
authors.initials: D
authors.lastname: Vohora
authors.forename: Razia
authors.initials: R
authors.lastname: Khanam
authors.forename: Shanthi N
authors.initials: SN
authors.lastname: Pal
authors.forename: K K
authors.initials: KK
authors.lastname: Pillai
mesh_terms: D000588:Amines / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology; D004338:Drug Combinations; D000077206:Gabapentin; D008297:Male; D008717:Methionine Sulfoximine / Q000633:toxicity*; D051379:Mice; D010880:Piperidines / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D014635:Valproic Acid / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D004338:Drug Combinations; D010880:Piperidines; D008717:Methionine Sulfoximine; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D000077206:Gabapentin; C052075:thioperamide