title: [False negative of the scintigraphy with 99mTc-sestamibi in parathyroid carcinoma with associated brown tumors. Contributions of the 18F-FDG-PET/CT].
abstract: Parathyroid carcinoma (PTC) is a rare malignant disease that is usually hyperfunctioning, which produces an excess of parathyroid hormone. Hyperparathyroidism causes bone metabolism disorders, as osteopenia and sometimes brown tumors. Brown tumors are benign but locally aggressive bone lesions, whose differential diagnosis with metastases or other primary malignancies may be complicated. (99m)Tc-Sestamibi scan is the usual procedure for the detection of parathyroid pathology, with a sensitivity of 85-100% and specificity close to 100% in parathyroid adenomas, it having similar percentages in the detection of PTC. We present the case of a patient diagnosed of a malignant hyperparathyroidism associated with bone lesions in which the (99m)Tc-Sestamibi scan showed a false negative result in the detection of parathyroid condition. However, (18)F-FDG-PET/CT detected the PTC and helped in the differential diagnosis of associated bone lesions, which were finally confirmed as brown tumors.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain. aliciasantiagochinchilla@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Santiago Chinchilla
authors.forename: C
authors.initials: C
authors.lastname: Ramos Font
authors.forename: M A
authors.initials: MA
authors.lastname: Muros de Fuentes
authors.forename: M
authors.initials: M
authors.lastname: Navarro-Pelayo Láinez
authors.forename: H
authors.initials: H
authors.lastname: Palacios Gerona
authors.forename: M
authors.initials: M
authors.lastname: Moreno Caballero
authors.forename: J M
authors.initials: JM
authors.lastname: Llamas Elvira
mesh_terms: D005188:False Negative Reactions; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D010002:Osteitis Fibrosa Cystica / Q000150:complications*; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D017256:Technetium Tc 99m Sestamibi