title: Electrospun scaffolds of self-assembling peptides with poly(ethylene oxide) for bone tissue engineering.
abstract: Structural, mechanical and biochemical properties have to be considered when searching for suitable extracellular matrix substitutes. Fibrous structures of synthetic or natural polymers have received increasing interest as three-dimensional scaffolds for tissue engineering applications as they can be easily produced by electrospinning with different topographical features by changing the process parameters. On the other hand, the nanobiotechnology approach suggests mimicking molecular architectures in nature through self-assembly. In particular, self-assembling peptide-based biomaterials have been successfully used as scaffolds for cell growth. In order to amalgamate these two strategies nanofibrous electrospun scaffolds of hybrid polymer were designed and obtained by mixing poly(ethylene oxide) and self-assembling peptides in aqueous solution. The results of in vitro osteoblast adhesion and proliferation assays on the electrospun scaffolds obtained using different self-assembling peptide sequences are discussed.
authors.affiliation: Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, via Gabelli 63, 35121 Padova, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Brun
authors.forename: Francesca
authors.initials: F
authors.lastname: Ghezzo
authors.forename: Martina
authors.initials: M
authors.lastname: Roso
authors.forename: Roberta
authors.initials: R
authors.lastname: Danesin
authors.forename: Giorgio
authors.initials: G
authors.lastname: Palù
authors.forename: Andrea
authors.initials: A
authors.lastname: Bagno
authors.forename: Michele
authors.initials: M
authors.lastname: Modesti
authors.forename: Ignazio
authors.initials: I
authors.lastname: Castagliuolo
authors.forename: Monica
authors.initials: M
authors.lastname: Dettin
mesh_terms: D000595:Amino Acid Sequence; D001846:Bone Development; D002478:Cells, Cultured; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D010455:Peptides; D011092:Polyethylene Glycols