title: [Compatible stability of reduning injection with solvents].
abstract: OBJECTIVE
  To investigate the compatible stability of Reduning injection in different dosages with 5% glucose injection and 0.9% sodium chloride injection.
  
  
  METHODS
  The changes before and after compatible application of Reduning injection with 5% glucose injection and 0.9% sodium chloride injection (5: 250, 10: 250, 20: 250, 30: 250, 40: 250, 50: 250, 62. 5: 250) on color, clarity, pH, main ingredients and atlas of HPLC were determined.
  
  
  RESULTS
  There were no difference in the color, clarity, pH, the main ingredients and liquid fingerprints of the mixture solutions, but the insoluble particles in them showed significant difference within 6 h.
  
  
  CONCLUSIONS
  Reduning injection is compatible in different concentrations with 5% glucose injection or 0.9% sodium chloride injection within 4 h, in clinic, it should be used within 2 h, the volume of Reduning injection with 5% glucose injection or 0.9% sodium chloride injection should be no more than 50 mL.
authors.affiliation: Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, Lianyungang 222001, China. lyg-czj@163.com
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D012997:Solvents / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D012997:Solvents