title: Analysis of molecular targets of Mycobacterium tuberculosis by analytical ultracentrifugation.
abstract: The interest in analytical ultracentrifugation (AUC) to analyze protein structural parameters and interactions has increased in the past decades as a result of several developments on new generation instrumentation and data analysis tools. In this article, we review AUC principles and applications to study proteins, emphasizing molecular targets of Mycobacterium tuberculosis.
authors.affiliation: Institute of Chemistry of São Carlos, University of São Paulo-USP, São Carlos, SP, 13560-970, Brazil. borgesjc@iqsc.usp.br
authors.forename: J C
authors.initials: JC
authors.lastname: Borges
authors.forename: C H I
authors.initials: CH
authors.lastname: Ramos
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry*; D057446:Hydrodynamics; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D017510:Protein Folding; D012984:Software; D014461:Ultracentrifugation
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins