title: Palmar-plantar erythrodysesthesia secondary to docetaxel chemotherapy: a case report.
abstract: BACKGROUND
  Docetaxel is a chemotherapeutic agent used alone or in combination for the management of many neoplastic conditions. Numerous side effects are well described as a consequence. Palmar-plantar erythrodysesthesia, although a relatively common side effect of some types of chemotherapy, occurs infrequently with docetaxel and is often attributed to other drug agents.
  
  
  METHODS
  We report the case of a 66-year-old Caucasian woman who received adjuvant docetaxel monotherapy for invasive breast cancer. She developed palmar-plantar erythrodysesthesia following her first cycle of treatment, which necessitated a change in management.
  
  
  CONCLUSIONS
  Palmar-plantar erythrodysesthesia is a relatively common side effect of cytotoxic chemotherapy, particularly with drugs such as 5-fluorouracil, capecitabine and liposomal doxorubicin. Docetaxel is commonly used both alone and in combination with a number of these agents for the management of various malignant conditions. We would like to highlight the occurrence of palmar-plantar erythrodysesthesia as a result of docetaxel monotherapy so that it can be considered as a potential cause in patients receiving combination treatment with chemotherapeutic agents better known to cause this toxicity.
authors.affiliation: 1Cancer Centre, University Hospital of North Staffordshire, Stoke-on-Trent, Newcastle Road, Staffordshire, ST4 6QG, UK. helenbenghiat@yahoo.com.
authors.forename: Helen
authors.initials: H
authors.lastname: Benghiat
authors.forename: Amjad
authors.initials: A
authors.lastname: Al-Niaimi