title: [Ectopic ACTH-secreting neuroendocrine tumor].
abstract: The authors report a case of an ectopic ACTH-syndrome that resulted in severe hypercortisolism, hypokalemia, diabetes mellitus and osteoporosis. The ACTH-secreting tumor tissue was localized in the lung. The tumor was removed by segmentectomy and histological evaluation revealed an ACTH-secreting neuroendocrine tumor. After surgery, however, plasma cortisol and ACTH levels failed to decrease significantly due to subtotal tumor removal. Long-acting somatostatin analogue therapy resulted in a normalization of both plasma cortisol and ACTH levels and the clinical symptoms improved significantly. Residual tumor was removed by repeat surgery and the patient was permanently cured.
authors.affiliation: Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház, II. Belgyógyászat, Miskolc.
authors.forename: Attila
authors.initials: A
authors.lastname: Szabó
authors.forename: Péter
authors.initials: P
authors.lastname: Igaz
authors.forename: Róbert
authors.initials: R
authors.lastname: Kiss
authors.forename: Gergely
authors.initials: G
authors.lastname: Lakatos
authors.forename: Ibolya
authors.initials: I
authors.lastname: Varga
authors.forename: Károly
authors.initials: K
authors.lastname: Rácz
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000150:complications* / Q000175:diagnosis*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D003480:Cushing Syndrome / Q000209:etiology; D003920:Diabetes Mellitus / Q000209:etiology; D006801:Humans; D007008:Hypokalemia / Q000209:etiology; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000150:complications* / Q000175:diagnosis*; D010024:Osteoporosis / Q000209:etiology; D011013:Pneumonectomy / Q000379:methods; D012086:Reoperation; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D013004:Somatostatin; D000324:Adrenocorticotropic Hormone