title: The association of HLA-DRB1 alleles with antineutrophil cytoplasmic antibody-associated systemic vasculitis in Chinese patients.
abstract: Antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis (AASV) is a group of autoimmune diseases. The human leukocyte antigen (HLA) system is devoted to the pathogenesis of these autoimmune diseases. The present study aimed to investigate the distribution of HLA-DRB1 alleles in Chinese AASV patients and its potential association with clinical and pathologic characteristics. This study included 152 Chinese patients with AASV and 200 healthy controls. Typing of HLA-DRB1 alleles was performed by bidirectional sequencing of exon 2. Compared with normal controls, DRB1*1454 was significantly less prevalent in AASV patients (0/304 vs 14/400, p = 4.6 × 10(-4), p corrected (p(c)) = 0.017), whereas DRB1*1101 was significantly more frequent in patients with MPA (32/214 vs 26/400, p = 6.4 × 10(-4), p(c) = 0.023). In patients with Wegener's granulomatosis (WG) who were PR3-ANCA positive, DRB1*1202 (8/38 vs 20/400, p = 1.3 × 10(-3), p(c) = 0.047) was more prevalent than in normal controls. Compared with normal controls, HLA-DRB1*1454 was less prevalent in AASV patients, whereas DRB1*1101 was significantly more frequent in patients with microscopic polyangiitis. HLA-DRB1*1202 was prevalent among patients with PR3-ANCA-positive WG.
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Luo
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Yang
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Xu
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D002681:China; D005260:Female; D056726:Genetic Association Studies; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D006684:HLA-DR Antigens / Q000235:genetics / Q000378:metabolism*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D056647:Systemic Vasculitis / Q000097:blood / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553514:HLA-DRB1*12:02 antigen