title: A double-blind, randomized, placebo-controlled study of the dopamine D₃ receptor antagonist ABT-925 in patients with acute schizophrenia.
abstract: There is substantial preclinical and clinical evidence to suggest a potential role for the dopamine D₃ receptor in the treatment of schizophrenia. ABT-925 is a selective dopamine D₃ receptor antagonist with an approximately 100-fold higher in vitro affinity for dopamine D₃ versus D₂ receptors. This double-blind, randomized, placebo-controlled, escalating-dose, parallel-group study assessed the efficacy and safety of ABT-925 in the treatment of patients with acute exacerbation of schizophrenia. One hundred fifty-five patients were assessed over a 6-week double-blind treatment period (placebo: n = 48; ABT-925 50 mg once daily [QD]: n = 53; ABT-925 150 mg QD: n = 54). The primary efficacy measure was mean change from baseline to final evaluation on the Positive and Negative Syndrome Scale total score. Secondary measures of efficacy and pharmacokinetic parameters were also assessed. Safety assessments included adverse event monitoring, laboratory tests, vital signs, movement rating scales, and electrocardiogram measures. No statistically significant treatment effect was observed with ABT-925 50 mg QD or 150 mg QD compared with placebo on primary or secondary efficacy end points. Pharmacokinetic parameter estimates increased with dose in a linear fashion. ABT-925 50 mg QD and 150 mg QD were generally well tolerated, with adverse event profiles similar to that of placebo. Findings from a concurrent positron emission tomography study among healthy volunteers suggest that the ABT-925 doses used in this study may not have been sufficient to adequately occupy D₃ receptors, thereby underscoring the importance of pharmacodynamic markers, such as PET, in determining appropriate compound doses before embarking on studies in a target population.
authors.affiliation: Abbott, Abbott Park, IL, USA. laura.redden@abbott.com
authors.forename: Laura
authors.initials: L
authors.lastname: Redden
authors.forename: Beatrice
authors.initials: B
authors.lastname: Rendenbach-Mueller
authors.forename: Walid M
authors.initials: WM
authors.lastname: Abi-Saab
authors.forename: David A
authors.initials: DA
authors.lastname: Katz
authors.forename: Armen
authors.initials: A
authors.lastname: Goenjian
authors.forename: Weining Z
authors.initials: WZ
authors.lastname: Robieson
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Wang
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Goss
authors.forename: Nicholas
authors.initials: N
authors.lastname: Greco
authors.forename: Mario D
authors.initials: MD
authors.lastname: Saltarelli
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D018492:Dopamine Antagonists / Q000494:pharmacology* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors* / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D018492:Dopamine Antagonists; D050637:Receptors, Dopamine D3