title: Effect of atorvastatin in a case of feline multicentric lymphoma - Case report.
abstract: A case of feline multicentric lymphoma is reported in an 8-year-old male cat weighing 4.7 kg. At the time of the clinical consultation the animal presented weight loss, anorexia and generalised lymphadenomegaly. After careful clinical observation and a detailed laboratory workup, the diagnosis of small cleaved cell lymphoma was established. It was classified as a stage III b multicentric lymphoma. Chemotherapy was initiated according to a classical COP protocol to which atorvastatin was added. After 34 months, the cat continues to enjoy an excellent quality of life with no clinical or haematological signs of lymphoma. This is the first report in clinical veterinary medicine about a new effective adjuvant therapy in feline multicentric lymphoma. Further studies are needed to confirm that the addition of atorvastatin can provide a regular, safe and improved treatment in feline lymphoma cases.
authors.affiliation: Laboratory of Molecular Oncology, Department of Science and Technology, Quilmes National University, Buenos Aires, Argentina. ghermo@unq.edu.ar
authors.forename: Guillermo A
authors.initials: GA
authors.lastname: Hermo
authors.forename: Hernán G
authors.initials: HG
authors.lastname: Farina
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Alonso
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Gomez
mesh_terms: D000818:Animals; D000069059:Atorvastatin; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D017024:Chemotherapy, Adjuvant; D006538:Heptanoic Acids / Q000627:therapeutic use*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011758:Pyrroles / Q000627:therapeutic use*
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin