title: Genotyping of Mycobacterium tuberculosis: application in epidemiologic studies.
abstract: Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies including the use of whole-genome sequencing technology. We also review the public health application of molecular epidemiologic tools.
authors.affiliation: University of California, San Francisco, Francis J Curry National Tuberculosis Center, Division of Pulmonary & Critical Care Medicine, San Francisco General Hospital, 1001 Potrero Avenue, Building 100, Room 109, Mail box 0841, San Francisco, CA 94110-0111, USA.
authors.forename: Midori
authors.initials: M
authors.lastname: Kato-Maeda
authors.forename: John Z
authors.initials: JZ
authors.lastname: Metcalfe
authors.forename: Laura
authors.initials: L
authors.lastname: Flores
mesh_terms: D015373:Bacterial Typing Techniques / Q000379:methods*; D004269:DNA, Bacterial / Q000235:genetics; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology / Q000379:methods; D058889:Molecular Typing / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D004269:DNA, Bacterial; D005819:Genetic Markers