title: High levels of anti-cyclic citrullinated peptide autoantibodies are associated with co-occurrence of pulmonary diseases with rheumatoid arthritis.
abstract: OBJECTIVE
  To investigate whether levels of anti-cyclic citrullinated peptide antibodies (anti-CCP2) in patients with rheumatoid arthritis (RA) are associated with the co-occurrence of lung diseases.
  
  
  METHODS
  A total of 252 RA patients were included in a cross-sectional study. Pulmonary disease was confirmed by high-resolution chest computed tomography scan. Circulating anti-CCP2 were quantified using ELISA. Multivariate logistic regression was conducted to identify independent risk factors for lung disease.
  
  
  RESULTS
  Male sex (OR 3.29, 95% CI 1.59-6.80) and high anti-CCP2 levels (OR 1.49, 95% CI 1.25-1.78) were identified as independent risk factors for lung disease in the RA population.
  
  
  CONCLUSIONS
  High anti-CCP2 levels are associated with lung disease in the RA population.
authors.affiliation: Service de Rhumatologie, Hôpital Bichat Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France.
authors.forename: Fleur
authors.initials: F
authors.lastname: Aubart
authors.forename: Bruno
authors.initials: B
authors.lastname: Crestani
authors.forename: Pascale
authors.initials: P
authors.lastname: Nicaise-Roland
authors.forename: Florence
authors.initials: F
authors.lastname: Tubach
authors.forename: Caroline
authors.initials: C
authors.lastname: Bollet
authors.forename: Karen
authors.initials: K
authors.lastname: Dawidowicz
authors.forename: Emilie
authors.initials: E
authors.lastname: Quintin
authors.forename: Gilles
authors.initials: G
authors.lastname: Hayem
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Palazzo
authors.forename: Olivier
authors.initials: O
authors.lastname: Meyer
authors.forename: Sylvie
authors.initials: S
authors.lastname: Chollet-Martin
authors.forename: Philippe
authors.initials: P
authors.lastname: Dieudé
mesh_terms: D001172:Arthritis, Rheumatoid / Q000453:epidemiology* / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000276:immunology*; D008297:Male; D010456:Peptides, Cyclic / Q000276:immunology*; D011237:Predictive Value of Tests; D012307:Risk Factors; D012737:Sex Factors; D014057:Tomography, X-Ray Computed
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide