title: Evaluation of antimicrobial effectiveness of C-8 xylitol monoester as an alternative preservative for cosmetic products.
abstract: Xylitol is a natural sugar derived from plants, fruits and vegetables, whose antimicrobial properties are described in the literature. This study aimed to evaluate the antimicrobial effectiveness of C-8 xylitol monoester, for its use as a preservative in cosmetic formulations. The minimum inhibitory concentration (MIC) was determined by the broth macrodilution method, and the antimicrobial effectiveness of C-8 xylitol monoester was determined by using challenge test method. The results obtained in the determination of minimum inhibitory concentration are between 1.0% and 1.25% for Staphylococcus aureus, Escherichia coli and Candida albicans and between 1.0% and 1.5% for Pseudomonas aeruginosa and Aspergillus niger. The amount of 1% of C-8 xylitol monoester was added to the lotion used in the challenge test, observing a rapid decline in the number of CFU g(-1) in stages of evaluation after contamination of the product by all bacteria. The same occurs in relation to C. albicans, which shows a 90% reduction in the number of CFU g(-1). Regarding A. niger, similar reduction is observed when pH value of the lotion is adjusted from 5.5 to 7.0. The results indicate that under the tests conditions, C-8 xylitol monoester has antimicrobial activity and could be considered as an alternative preservative for cosmetic formulations.
authors.affiliation: Department of Clinical Pathology, Faculty of Medical Sciences - University of Campinas, Rua Tessália Vieira de Camargo, 126 - Campinas, SP, Brazil. liufbarbosa@yahoo.com.br
authors.forename: L F B
authors.initials: LF
authors.lastname: Amaral
authors.forename: N S
authors.initials: NS
authors.lastname: Camilo
authors.forename: M D C V
authors.initials: MD
authors.lastname: Pereda
authors.forename: C E
authors.initials: CE
authors.lastname: Levy
authors.forename: P
authors.initials: P
authors.lastname: Moriel
authors.forename: P G
authors.initials: PG
authors.lastname: Mazzola
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D003358:Cosmetics; D004952:Esters; D008826:Microbial Sensitivity Tests; D014993:Xylitol / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D003358:Cosmetics; D004952:Esters; D014993:Xylitol