title: The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5α-reductase-2 gene mutation.
abstract: OBJECTIVE
  To report a case of successful paternity from a male homozygous for 5α-reductase-2 deficiency.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Academic center, division of reproductive endocrinology.
  
  
  METHODS
  A 45-year-old Dominican man and his 32-year-old wife.
  
  
  METHODS
  In vitro fertilization and intracytoplasmic sperm injection.
  
  
  METHODS
  Pregnancy.
  
  
  RESULTS
  Viable twin gestation.
  
  
  CONCLUSIONS
  Men homozygous for 5α-reductase-2 deficiency can achieve biologic paternity through in vitro fertilization with intracytoplasmic sperm injection despite severely abnormal semen parameters.
authors.affiliation: Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Department of Medicine/Endocrinology, Weill Medical College of Cornell University, New York, New York 10021, USA.
authors.forename: Hey-Joo
authors.initials: HJ
authors.lastname: Kang
authors.forename: Julianne
authors.initials: J
authors.lastname: Imperato-McGinley
authors.forename: Yuan-Shan
authors.initials: YS
authors.lastname: Zhu
authors.forename: Li-Qun
authors.initials: LQ
authors.lastname: Cai
authors.forename: Peter
authors.initials: P
authors.lastname: Schlegel
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Palermo
authors.forename: Zev
authors.initials: Z
authors.lastname: Rosenwaks
mesh_terms: D000328:Adult; D001483:Base Sequence; D042944:Cholestenone 5 alpha-Reductase / Q000235:genetics*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006720:Homozygote; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000502:physiology; D010298:Parity; D010334:Paternity; D011247:Pregnancy; D011272:Pregnancy, Multiple; D020554:Sperm Injections, Intracytoplasmic; D014427:Twins
chemical_list: D042944:Cholestenone 5 alpha-Reductase