title: Bioactive isocoumarins from a terrestrial Streptomyces sp. ANK302.
abstract: Four isocoumarins have been isolated from the terrestrial Streptomyces sp. ANK302, namely 6,8-dimethoxy-3-methylisocoumarin (1), 6,8-dihydroxy-3-methylisocoumarin (2), 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (3), and 6,7,8-trimethoxy-3-methylisocoumarin (4). Compound 1 is a new naturally-occurring isocoumarin, and 2 was isolated as a new bacterial product. The structures 1-4 were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. Compound 2 showed a strong zoosporicidal activity at a concentration of 5 microg/mL against a phytopathogenic oomycete, Plasmopara viticola, and 1 was active against
authors.affiliation: Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
authors.forename: Dhafer Saber
authors.initials: DS
authors.lastname: Zinad
authors.forename: Khaled A
authors.initials: KA
authors.lastname: Shaaban
authors.forename: Muna Ali
authors.initials: MA
authors.lastname: Abdalla
authors.forename: Md Tofazzal
authors.initials: MT
authors.lastname: Islam
authors.forename: Anja
authors.initials: A
authors.lastname: Schüffler
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009868:Oomycetes / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D049934:Isocoumarins