title: Anti-inflammatory activities of aqueous/ethanol and methanol extracts of Perna viridis Linn. in mice.
abstract: Anti-inflammatory effect of the edible mytilid bivalve Perna viridis was evaluated using formalin, carrageenan and dextran-induced paw oedema in mice. The whole mussel tissue without shell was first extracted with ethyl acetate and then successively with methanol and water:ethanol, 7:3 (aqueous/ethanol). Three doses (100, 500 and 1,000 mg/kg) of the extracts (methanol and aqueous/ethanol) were administered orally prior to the injection of inflammatory agents. The inflammation induced by formalin was inhibited by the administration of both extracts for 7 days and the activity was found to be higher for methanol than aqueous/ethanol extract. A dose-dependent reduction in paw thickness was observed for carrageenan-induced paw oedema on treatment with methanol and aqueous/ethanol extracts which was comparable to the standard drug diclofenac. The effect of extracts on dextran-induced oedema was less than that produced by the other two inflammatory stimulants.
authors.affiliation: Department of Marine biology, Microbiology and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology, Fine arts Avenue, Cochin, 682016 Kerala, India. sreejakl@gmail.com
authors.forename: K L
authors.initials: KL
authors.lastname: Sreejamole
authors.forename: C K
authors.initials: CK
authors.lastname: Radhakrishnan
authors.forename: J
authors.initials: J
authors.lastname: Padikkala
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D049872:Bivalvia / Q000737:chemistry; D002351:Carrageenan / Q000009:adverse effects; D004008:Diclofenac / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D000431:Ethanol / Q000737:chemistry; D005557:Formaldehyde / Q000009:adverse effects; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D000432:Methanol / Q000737:chemistry; D051379:Mice; D049883:Perna / Q000737:chemistry*; D014020:Tissue Extracts / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D014020:Tissue Extracts; D004008:Diclofenac; D005557:Formaldehyde; D000431:Ethanol; D002351:Carrageenan; D000432:Methanol