title: 8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment.
abstract: Malignant gliomas continue to demand the search for improved chemotherapeutic solutions. In this work the results of a preliminary in vitro screening performed on a small library of compounds are disclosed. As a result 2-(2,4-dihydroxyphenyl)-8-hydroxy-1,4-naphthoquinone emerged as a promising therapeutic lead.
authors.affiliation: Department of Pharmaceutical Sciences, University of Padova, Padova, Italy. giuseppe.zagotto@unipd.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zagotto
authors.forename: Marco
authors.initials: M
authors.lastname: Redaelli
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pasquale
authors.forename: Domenico
authors.initials: D
authors.lastname: D'Avella
authors.forename: Giorgio
authors.initials: G
authors.lastname: Cozza
authors.forename: Luca
authors.initials: L
authors.lastname: Denaro
authors.forename: Francesca
authors.initials: F
authors.lastname: Pizzato
authors.forename: Carla
authors.initials: C
authors.lastname: Mucignat-Caretta
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001932:Brain Neoplasms / Q000473:pathology*; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D009281:Naphthalenes