title: Synthesis of calophyllolide analogue and its preliminary anti-inflammatory activity.
abstract: A new pyranocoumarin as an analogue of calophyllolide, compound 6, is firstly prepared and reported to have potent anti-inflammatory activity on carrageenin-induced edema in rats.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Ma
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Gui-fang
authors.initials: GF
authors.lastname: Cheng
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002351:Carrageenan; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar
chemical_list: C574968:(2,2-dimethyl-8-oxo-10-phenyl-pyrano(2,3f)chromen-5-yl)(E)-but-2-enoate; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003374:Coumarins; C018859:calophyllolid; D002351:Carrageenan