title: HIV-infected hospitalized patients with 2009 pandemic influenza A (pH1N1)--United States, spring and summer 2009.
abstract: We describe the clinical findings of HIV-infected patients hospitalized with 2009 pandemic influenza A (pH1N1). Data were derived from 3 separate case series in the United States. Among 911 adults hospitalized with pH1N1 influenza, 31 (3.4%) were HIV infected compared with an HIV prevalence of 0.45% in the general US adult population. HIV-infected influenza patients experienced similar rates of intensive care unit admission (29% vs 34%) and death (13% vs 13%) compared with non-HIV-infected patients. Among HIV-infected patients with available data, 14 (50%) of 28 patients had a CD4 cell count <200 cells/μL, which was not associated with an increased risk of an intensive care unit admission or death. Overall, 25 (81%) HIV-infected patients received influenza antiviral therapy, but treatment was initiated within 48 h of illness onset in only 33% of cases. Clinicians should consider early empiric influenza antiviral treatment in HIV-infected patients presenting with suspected influenza.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. pjpeters@cdc.gov
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Peters
authors.forename: Jacek
authors.initials: J
authors.lastname: Skarbinski
authors.forename: Janice K
authors.initials: JK
authors.lastname: Louie
authors.forename: Seema
authors.initials: S
authors.lastname: Jain
authors.forename: Michelle
authors.initials: M
authors.lastname: Roland
authors.forename: Shilpa G
authors.initials: SG
authors.lastname: Jani
authors.forename: Lyn
authors.initials: L
authors.lastname: Finelli
authors.forename: John T
authors.initials: JT
authors.lastname: Brooks
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000008:administration & dosage; D015897:Comorbidity; D003422:Critical Care / Q000706:statistics & numerical data; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D058873:Pandemics; D012621:Seasons; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000998:Antiviral Agents