title: Association of catechol-O-methyl transferase (COMT) gene -287A/G polymorphism with susceptibility to obsessive-compulsive disorder in Chinese Han population.
abstract: Several studies suggested a genetic component in the etiology of obsessive-compulsive disorder (OCD). COMT involves in the degradation of dopamine and norepinephrin. As another functional SNP locus, COMT -287A/G polymorphism showed an effect on enzyme activity, suggesting that it may influence brain dopamine levels. To identify association of COMT -287A/G polymorphism with susceptibility to OCD in Chinese Han population. We evaluate the genetic contribution of the COMT -287A/G polymorphism in 200 OCD patients and 403 OCD-free control of Chinese Han population by PCR-RFLP. In addition, we investigate whether COMT -287A/G polymorphism is associated with one or more of these symptom dimensions or other characteristics such as sex, age of onset, and tic-relatedness and evaluate the association of the factorial structure of OCD symptoms from the Y-BOCS checklist with the COMT -287A/G polymorphism. A statistical difference was found in the genotypic frequencies of COMT -287A/G between the OCD and control groups (χ(2)  = 13.99, DF = 2, P = 0.00091) and in the genotypic frequencies of GG genotype versus AA and AG genotypes of COMT -287 (χ(2)  = 13.49, DF = 1, P = 0.00024, OR = 3.43, 95% CI = 1.78-6.62). There was a trend for an association in the genotypic distributions of COMT -287A/G polymorphism of males (χ(2)  = 27.81; DF = 2; P < 0.001) and females (χ(2)  = 7.31; DF = 2; P = 0.026) between the OCD patients and the controls. Using principal component analysis, we derived 5 factors from 12 main contents of OCD symptoms from the Y-BOCS checklist and found no association with COMT -287A/G polymorphism. Our study supports the involvement of the COMT -287A/G polymorphism in the genetic susceptibility to OCD in Chinese Han population.
authors.affiliation: Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Liu
authors.forename: Haiping
authors.initials: H
authors.lastname: Wang
authors.forename: Ruiling
authors.initials: R
authors.lastname: Zhou
authors.forename: Jinbao
authors.initials: J
authors.lastname: Zong
authors.forename: Changgui
authors.initials: C
authors.lastname: Li
authors.forename: Xinhua
authors.initials: X
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002681:China / Q000208:ethnology; D004298:Dopamine / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D002394:Catechol O-Methyltransferase; D004298:Dopamine