title: [Pharmacokinetics studies on tetramethylpyrazine by intravenous administration in rats].
abstract: OBJECTIVE
  To investigate the pharmacokinetics behaviour of tetramethylpyrazine (TMP) by intravenous administration in rats.
  
  
  METHODS
  Methanol-0.05 mol/L acetate buffer solution (50:50,V/V) was used as mobile phase with a flow rate of 1.0 mL/min. The UV detection wavelength was 280 nm.
  
  
  RESULTS
  The profile of TMP in blood fitted a two-compartment model. The half time of drug distribution and elimination was short. The mean residence time MRT 0-infinity was 141.61 min, and the AUC0-infinity was 7521.70 microg x min/ mL.
  
  
  CONCLUSIONS
  After intravenous injection, the pharmacokinetics behaviour of TMP fit a two-compartment model in rats. Both the distribution and the elimination are fast.
authors.affiliation: Jinan University, College of Pharmacy, Guangzhou 510632, China.
authors.forename: Hai-Nan
authors.initials: HN
authors.lastname: Chen
authors.forename: Sha
authors.initials: S
authors.lastname: Li
authors.forename: Xing-Li
authors.initials: XL
authors.lastname: Wang
authors.forename: Yu-Qiang
authors.initials: YQ
authors.lastname: Wang
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D007267:Injections; D030004:Ligusticum / Q000737:chemistry; D023421:Models, Animal; D015394:Molecular Structure; D011719:Pyrazines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D004365:Drugs, Chinese Herbal; D011719:Pyrazines; D014665:Vasodilator Agents; C017953:tetramethylpyrazine