title: Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery.
abstract: Liposome-loaded microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. In this paper we design liposome-loaded (lipid-shelled) microbubbles through the simple self-assembly of the involved compounds in a single step process. We thoroughly characterized the liposome-loading of the microbubbles and evaluated the cell killing efficiency of this material using doxorubicin (DOX) as a model drug. Importantly, we observed that the DOX liposome-loaded microbubbles allowed killing of melanoma cells even at very low doses of DOX. These findings clearly prove the potential of liposome-loaded microbubbles for ultrasound targeted drug delivery to cancer tissues.
authors.affiliation: Ghent Research Group on Nanomedicines, Lab of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Gent, Belgium.
authors.forename: Bart
authors.initials: B
authors.lastname: Geers
authors.forename: Ine
authors.initials: I
authors.lastname: Lentacker
authors.forename: Niek N
authors.initials: NN
authors.lastname: Sanders
authors.forename: Joseph
authors.initials: J
authors.lastname: Demeester
authors.forename: Stephen
authors.initials: S
authors.lastname: Meairs
authors.forename: Stefaan C
authors.initials: SC
authors.lastname: De Smedt
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism; D008545:Melanoma / Q000188:drug therapy*; D045423:Microbubbles; D010949:Plasma / Q000378:metabolism; D014465:Ultrasonics / Q000379:methods*
chemical_list: D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D004317:Doxorubicin