title: Patterns of accentuated grey-white differentiation on diffusion-weighted imaging or the apparent diffusion coefficient maps in comatose survivors after global brain injury.
abstract: OBJECTIVE
  To determine what disease entities show accentuated grey-white differentiation of the cerebral hemisphere on diffusion-weighted images (DWI) or apparent diffusion coefficient (ADC) maps, and whether there is a correlation between the different patterns and the cause of the brain injury.
  
  
  METHODS
  The DWI and ADC maps of 19 patients with global brain injury were reviewed and evaluated to investigate whether there was a correlation between the different patterns seen on the DWI and ADC maps and the cause of global brain injury. The ADC values were measured for quantitative analysis.
  
  
  RESULTS
  There were three different patterns of ADC decrease: a predominant ADC decrease in only the cerebral cortex (n=8; pattern I); an ADC decrease in both the cerebral cortex and white matter (WM) and a predominant decrease in the WM (n=9; pattern II); and a predominant ADC decrease in only the WM (n=3; pattern III).
  
  
  CONCLUSIONS
  Pattern I is cerebral cortical injury, suggesting cortical laminar necrosis in hypoxic brain injury. Pattern II is cerebral cortical and WM injury, frequently seen in brain death, while pattern 3 is mainly WM injury, especially found in hypoglycaemic brain injury. It is likely that pattern I is decorticate injury and pattern II is decerebrate injury in hypoxic ischaemic encephalopathy.Patterns I and II are found in severe hypoxic brain injury, and pattern II is frequently shown in brain death, whereas pattern III was found in severe hypoglycaemic injury.
authors.affiliation: Department of Radiology, Samsung Medical Center, 50 Irwon-dong, Seoul, Republic of Korea. xmida@hanmail.net
authors.forename: E
authors.initials: E
authors.lastname: Kim
authors.forename: C-H
authors.initials: CH
authors.lastname: Sohn
authors.forename: K-H
authors.initials: KH
authors.lastname: Chang
authors.forename: H-W
authors.initials: HW
authors.lastname: Chang
authors.forename: D H
authors.initials: DH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D003128:Coma / Q000473:pathology* / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D018450:Disease Progression; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology* / Q000502:physiology; D011379:Prognosis; D017741:Survivors