title: Prediction of bronchopulmonary dysplasia.
abstract: OBJECTIVE
  To determine whether elevation of a biological marker of inflammation would be a better predictor of bronchopulmonary dysplasia (BPD) development than lung function measurement results.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Tertiary neonatal intensive care unit.
  
  
  METHODS
  78 prematurely born infants (median gestational age 29 (range 24-32) weeks) were studied; 39 developed BPD.
  
  
  METHODS
  BPD was diagnosed as oxygen dependence at 28 days.
  
  
  METHODS
  Levels of a biological marker of inflammation (carbon monoxide) were assessed by measurement of end-tidal carbon monoxide (ETCO) and lung function by measurement of functional residual capacity (FRC) and compliance (Crs) and resistance (Rrs) of the respiratory system on days 3 and 14 after birth. Possible predictive factors were modelled for BPD and for BPD severity.
  
  
  RESULTS
  Gestational age, birth weight, ETCO, FRC and Crs results on days 3 and 14 differed significantly between infants who did and did not develop BPD. In multifactorial logistic regression, only birth weight and ETCO results (on day 14) remained significant predictors of BPD with an area under the curve of 0.97. The final multifactorial model for the severity of BPD included those two factors, plus septic episodes.
  
  
  CONCLUSIONS
  These results emphasise the importance of ongoing inflammation in the development of BPD; ETCO levels, rather than lung function test results, were the more accurate predictor of BPD development.
authors.affiliation: Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.
authors.forename: Caroline
authors.initials: C
authors.lastname: May
authors.forename: Sabina
authors.initials: S
authors.lastname: Patel
authors.forename: Caroline
authors.initials: C
authors.lastname: Kennedy
authors.forename: Elena
authors.initials: E
authors.lastname: Pollina
authors.forename: Gerrard F
authors.initials: GF
authors.lastname: Rafferty
authors.forename: Janet L
authors.initials: JL
authors.lastname: Peacock
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001724:Birth Weight; D001944:Breath Tests / Q000379:methods; D001997:Bronchopulmonary Dysplasia / Q000175:diagnosis / Q000209:etiology*; D002248:Carbon Monoxide / Q000378:metabolism; D005260:Female; D005652:Functional Residual Capacity; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000209:etiology*; D007249:Inflammation / Q000150:complications*; D018836:Inflammation Mediators / Q000378:metabolism*; D008170:Lung Compliance / Q000502:physiology; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002248:Carbon Monoxide