title: Analysis of hemodynamic performance of the bovine pericardium valved conduit, implanted in the aortic position in ovines.
abstract: OBJECTIVE
  The necessity for replacement of the valve, ascending aorta and aortic with coronary reimplantation in patients where anti-coagulation is undesirable, is increasing. We evaluated the hemodynamic performance of an aortic valved conduit made with glutaraldehyde treated bovine pericardium (AVCP) in animals.
  
  
  METHODS
  Therefore, AVCPs were implanted in eight young ovine and explanted after 150 days. Angiographic and hemodynamic study was performed at pre-operative and prior the explant. EchoDopplercardiograms were performed at day 30 and 150 of post-operative (test) and also in five nonoperated ovines. After explanted, AVCPs were submitted to a macroscopical, radiological and histological evaluation by optic microscopy.
  
  
  RESULTS
  In the hemodynamic analysis the arterial and pulmonary capillary pressure increased (P<0.05) between day 0 and 150. In the echoDoppercardiographic analysis, the test group presented higher values in the diastolic and systolic diameters of the left ventricle (P<0.05). In the test group, between day 30 and 150, occurred an increase of weight, thickness of the left ventricle walls, maximum transvalvar gradient, medium transvalvar gradient, left ventricle diastolic diameter and a decrease in the ejection function (P<0.05). Two animals with endocarditis explain those differences, how we can see with the statistical analysis without this sample. Macroscopy showed calcification in variable degrees. Optic microscopy revealed data similar to literature with the use of glutaraldehyde treated bovine pericadium.
  
  
  CONCLUSIONS
  These data indicate that the AVCPs allows the performance of this kind of experiment in the proposed model and that the hemodynamic outcomes found are similar to physiological parameters.
authors.affiliation: Faculdade de Medicina, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. jjmamaral@yahoo.com.br
authors.forename: Josalmir José Melo do
authors.initials: JJ
authors.lastname: Amaral
authors.forename: Pablo Maria Alberto
authors.initials: PM
authors.lastname: Pomerantzeff
authors.forename: Ivan Sergio Joviano
authors.initials: IS
authors.lastname: Casagrande
authors.forename: Idágene Aparecida
authors.initials: IA
authors.lastname: Cestari
authors.forename: Paulo Sampaio
authors.initials: PS
authors.lastname: Gutierrez
authors.forename: Noedir Groppo
authors.initials: NG
authors.lastname: Stolf
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology / Q000601:surgery*; D001021:Aortic Valve / Q000473:pathology / Q000601:surgery*; D001705:Bioprosthesis; D001794:Blood Pressure / Q000502:physiology*; D002417:Cattle; D005260:Female; D005976:Glutaral / Q000494:pharmacology; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006352:Heart Ventricles / Q000473:pathology; D008297:Male; D023421:Models, Animal; D010496:Pericardium / Q000187:drug effects / Q000637:transplantation*; D011897:Random Allocation; D012756:Sheep
chemical_list: D005976:Glutaral