title: New flagellin gene for Salmonella enterica serovar Typhi from the East Indonesian archipelago.
abstract: Phase variation is a property unique of some Salmonella enterica serovar Typhi strains from Indonesia. Salmonella Typhi isolates from Indonesia have been described that in addition to the phase 1 Hd flagellin gene contain a second flagellin gene named z66. S. Typhi isolates from Indonesia with a mutant Hd gene named Hj have also been described. Here, we have identified another flagellin gene of S. Typhi, named Ind, showing a closest homology with the flagellin gene of Serratia marcescens. The Ind gene was detected in 21.8% of the S. Typhi isolates from the East Indonesian archipelago, all of which contained the Hd gene. The Hj gene was not detected. The z66 gene was present in 15.4% of the isolates. The presence of these "foreign" flagellin genes could be associated with an increased risk for developing severe disease.
authors.affiliation: Department of Medical Microbiology, Molecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin University, Makassar, South-Sulawesi, Indonesia. hattaram@indosat.net.id
authors.forename: Mochammad
authors.initials: M
authors.lastname: Hatta
authors.forename: Andi R
authors.initials: AR
authors.lastname: Sultan
authors.forename: Rob
authors.initials: R
authors.lastname: Pastoor
authors.forename: Henk L
authors.initials: HL
authors.lastname: Smits
mesh_terms: D005408:Flagellin / Q000235:genetics*; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D012485:Salmonella typhi / Q000235:genetics* / Q000378:metabolism*; D014435:Typhoid Fever / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D005408:Flagellin