title: [Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].
abstract: After oral administration of Salvia miltiorrhiza (Danshen in Chinese), Panax notoginseng (Sanqi in Chinese) and Danshen Sanqi combination suspensions to Beagle dogs, the plasma concentration-time profiles of danshensu, tanshinone II(A), cryptotanshinone, notoginsenoside R1, ginsenoside Rg1 and Rb1 were analyzed by LC-MS/MS. Pharmacokinetic parameters were calculated and analyzed with BAPP 2.0 software. The results showed that the Cmax and AUC of danshensu, notoginsenoside R1, ginsenoside Rg1 and Rb1 in Danshen Sanqi combination group all decreased in comparison with those of Danshen or Sanqi given alone, while the CLz/F and Vz/F increased to some extent. No significant differences of the pharmacokinetics of tanshinone II(A) and cryptotanshinone were observed between groups.
authors.affiliation: Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Si-yun
authors.initials: SY
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Song
authors.forename: Jun-Gang
authors.initials: JG
authors.lastname: Lu
authors.forename: Tai-Jun
authors.initials: TJ
authors.lastname: Hang
mesh_terms: D045784:Abietanes / Q000097:blood / Q000493:pharmacokinetics; D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D036145:Ginsenosides / Q000097:blood / Q000493:pharmacokinetics; D007773:Lactates / Q000097:blood / Q000493:pharmacokinetics; D008297:Male; D053723:Panax notoginseng / Q000737:chemistry*; D010616:Phenanthrenes / Q000097:blood / Q000493:pharmacokinetics; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry*
chemical_list: D045784:Abietanes; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D007773:Lactates; D010616:Phenanthrenes; C021751:tanshinone; C035055:3,4-dihydroxyphenyllactic acid; C037886:cryptotanshinone; C442759:ginsenoside Rb1; C035054:ginsenoside Rg1; C072936:notoginsenoside R1