title: Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses.
abstract: Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one example of a bio-process at the plasma membrane. Our study thus suggests that the use of repetitive high-intensity voltage pulses could open up possibilities for a host of synergistic bio-responses involving both thermal and electrically driven phenomena.
authors.affiliation: Department of Electrical and Computer Engineering and Frank Reidy Center for Bio-Electrics, Old Dominion University, Norfolk, VA 23529-0246, USA.
authors.forename: J
authors.initials: J
authors.lastname: Song
authors.forename: R P
authors.initials: RP
authors.lastname: Joshi
authors.forename: K H
authors.initials: KH
authors.lastname: Schoenbach
mesh_terms: D002462:Cell Membrane / Q000502:physiology; D018274:Electroporation / Q000379:methods*; D006358:Hot Temperature; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008954:Models, Biological; D013997:Time Factors