title: Development of proteomics-based fungicides: new strategies for environmentally friendly control of fungal plant diseases.
abstract: Proteomics has become one of the most relevant high-throughput technologies. Several approaches have been used for studying, for example, tumor development, biomarker discovery, or microbiology. In this "post-genomic" era, the relevance of these studies has been highlighted as the phenotypes determined by the proteins and not by the genotypes encoding them that is responsible for the final phenotypes. One of the most interesting outcomes of these technologies is the design of new drugs, due to the discovery of new disease factors that may be candidates for new therapeutic targets. To our knowledge, no commercial fungicides have been developed from targeted molecular research, this review will shed some light on future prospects. We will summarize previous research efforts and discuss future innovations, focused on the fight against one of the main agents causing a devastating crops disease, fungal phytopathogens.
authors.affiliation: Laboratory of Microbiology, Faculty of Marine and Environmental Sciences, University of Cádiz, Pol. Río San Pedro s/n, 11510 Puerto Real, Spain.
authors.forename: Francisco Javier Fernández
authors.initials: FJ
authors.lastname: Acero
authors.forename: María
authors.initials: M
authors.lastname: Carbú
authors.forename: Mohamed Rabie
authors.initials: MR
authors.lastname: El-Akhal
authors.forename: Carlos
authors.initials: C
authors.lastname: Garrido
authors.forename: Victoria E
authors.initials: VE
authors.lastname: González-Rodríguez
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Cantoral
mesh_terms: D005659:Fungicides, Industrial; D008962:Models, Theoretical; D010935:Plant Diseases / Q000382:microbiology*; D040901:Proteomics / Q000379:methods*
chemical_list: D005659:Fungicides, Industrial