title: Effects of body fat on the associations of high-molecular-weight adiponectin, leptin and soluble leptin receptor with metabolic syndrome in Chinese.
abstract: BACKGROUND
  Little is known regarding the associations between high-molecular-weight (HMW-) adiponectin, leptin and soluble leptin receptor (sOB-R) and metabolic syndrome (MetS) in Chinese. Also few studies elucidate the effects of inflammation and body fat mass on the relations.
  
  
  METHODS
  Plasma HMW-adiponectin, leptin and sOB-R were measured among 1055 Chinese men and women (35∼54 yrs). Whole body and trunk fat mass were determined by Dual-energy X-ray absorptiometry. MetS was defined by the updated NCEP/ATPIII criterion for Asian-Americans.
  
  
  RESULTS
  HMW-adiponectin was inversely associated with MetS in multivariate model including fat mass index (FMI), inflammatory markers, leptin and sOB-R (OR in the highest quartile= 0.30, 95%CI 0.18∼0.50, P<.0001). Plasma sOB-R was also inversely associated with MetS independent of body fatness and inflammatory markers, whereas the association was somewhat attenuated after adjusting HMW-adiponectin (OR for the highest quartile = 0.78, 95%CI 0.47∼1.32, P = 0.15). In contrast, leptin was associated with increased odds of MetS independent of inflammatory markers, HMW-adiponectin, and sOB-R (OR for the highest quartile= 2.64, 95%CI 1.35∼5.18, P = 0.006), although further adjustment for FMI abolished this association.
  
  
  CONCLUSIONS
  HMW-adiponectin exhibited strong inverse associations with MetS independent of body composition, inflammation, leptin and sOB-R; while the associations of leptin and sOB-R were largely explained by fat mass or HMW-adiponectin, respectively.
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Danxia
authors.initials: D
authors.lastname: Yu
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Yu
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.forename: Huaixing
authors.initials: H
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Song
authors.forename: Ming
authors.initials: M
authors.lastname: Mi
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wu
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.forename: Geng
authors.initials: G
authors.lastname: Zhang
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Xu
authors.initials: X
authors.lastname: Lin
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D044466:Asian People; D015415:Biomarkers / Q000378:metabolism; D050218:Body Fat Distribution; D015992:Body Mass Index; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D008875:Middle Aged; D008970:Molecular Weight; D054411:Receptors, Leptin / Q000097:blood* / Q000737:chemistry; D012307:Risk Factors; D012995:Solubility
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D054411:Receptors, Leptin