title: CD4(+) T cells from MHC II-dependent thymocyte-thymocyte interaction provide efficient help for B cells.
abstract: Recently, a novel CD4(+) T-cell developmental pathway was reported that generates thymocyte-thymocyte (T-T) CD4(+) T cells. We established a mouse system (CIITA(tg)CIITApIV(-/-)) where thymic positive selection occurred only by major histocompatibility complex (MHC) class II(+) thymocytes. T-T CD4(+) T cells selected via MHC class II-dependent T-T interaction are comprised of PLZF-negative and innate PLZF-positive populations. Until recently, the functional role of the PLZF-negative population was unclear. In this study, we demonstrate that naïve T-T CD4(+) T cells provide B-cell help to a level comparable with that of naïve conventional CD4(+) T cells. Considering the absence of PLZF expression in naïve T-T CD4(+) T cells, these results suggest that PLZF-negative naïve T-T CD4(+) T cells are functionally equivalent to conventional naïve CD4(+) T cells in terms of B-cell help.
authors.affiliation: Graduate School of Immunology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Kim
authors.forename: Bomi
authors.initials: B
authors.lastname: Choi
authors.forename: Hana
authors.initials: H
authors.lastname: Moon
authors.forename: You Jeong
authors.initials: YJ
authors.lastname: Lee
authors.forename: Yoon Kyeong
authors.initials: YK
authors.lastname: Jeon
authors.forename: Seong Hoe
authors.initials: SH
authors.lastname: Park
authors.forename: Tae Jin
authors.initials: TJ
authors.lastname: Kim
authors.forename: Kyeong Cheon
authors.initials: KC
authors.lastname: Jung
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D000075722:Promyelocytic Leukemia Zinc Finger Protein; D060168:Thymocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D000949:Histocompatibility Antigens Class II; D051741:Kruppel-Like Transcription Factors; D000075722:Promyelocytic Leukemia Zinc Finger Protein; C513267:Zbtb16 protein, mouse