title: The evolving role of mTOR inhibition in transplantation tolerance.
abstract: The mammalian target of rapamycin (mTOR) plays a key role in the immune response. mTOR inhibitors suppress T cell activation and proliferation and are effective immunosuppressants. Today there is growing interest in their potential role in inducing tolerance after transplantation. mTOR inhibitors induce anergy in naïve T cells, promote the expansion of regulatory T cells, and inhibit the maturation of dendritic cells, thus promoting immunologic tolerance. Here we review the mechanisms by which mTOR inhibitors promote tolerance. We discuss the clinical relevance of these mechanisms and suggest how they might be used in the design of future protocols to induce tolerance.
authors.affiliation: Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA. gearoid.mcmahon@childrens.harvard.edu
authors.forename: Gearoid
authors.initials: G
authors.lastname: McMahon
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Weir
authors.forename: Xian C
authors.initials: XC
authors.lastname: Li
authors.forename: Didier A
authors.initials: DA
authors.lastname: Mandelbrot
mesh_terms: D049109:Cell Proliferation; D017635:Clonal Anergy / Q000276:immunology / Q000502:physiology; D006084:Graft Rejection / Q000517:prevention & control; D006085:Graft Survival / Q000276:immunology / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: D058570:TOR Serine-Threonine Kinases