title: Randomized controlled, multicentre clinical trial comparing a dual-probe ultrasonic lithotrite with a single-probe lithotrite for percutaneous nephrolithotomy.
abstract: OBJECTIVE
  • To compare the Cyberwand (Gyrus/ACMI, Southborough, MA, USA), a dual-probe ultrasonic lithotrite, with a single-probe ultrasonic lithotrite. • The Cyberwand incorporates coaxial high- and low-frequency ultrasonic probes that work synergistically.
  
  
  METHODS
  • An institutional review board-approved, multicentre, randomized controlled trial to compare the Cyberwand to the Olympus LUS-II (Olympus America, Inc., Melville, NY, USA) single-probe lithotrite was performed. • Patients undergoing a percutaneous nephrolithotomy (PCNL) with a target stone > 2 cm in diameter were eligible for the study. • The primary outcome was the time to removal of the targeted stone.
  
  
  RESULTS
  • A total of 57 PCNLs were performed after randomization: 25 Cyberwand and 32 LUS-II. • There was no difference (P > 0.05) observed between the two devices for target stone surface area (Cyberwand 526.6 cm³ vs LUS-II 540.1 cm³), time to clearance of target stone (Cyberwand 15.8 min vs LUS-II 14.2 min) and target stone clearance rate (Cyberwand 61.9 mm²/min vs LUS-II 75.8 mm²/min). • Of the patients with stone analysis, hard stones (calcium oxalate monohydrate, brushite and cystine) were noted in 14 (56.0%) of the 25 Cyberwand and 18 (62.1%) of the 29 LUS-II patients. • Fifteen of the 25 (60.0%) Cyberwand and 20 of the 32 (62.5%) LUS-II patients were stone-free after the initial PCNL. • Those patients not rendered stone-free went on to receive a secondary PCNL. • Device malfunction occurred in eight of 25(32.0%) Cyberwand and five of 32 (15.6%) LUS II patients. • Complications were similar in both treatment groups.
  
  
  CONCLUSIONS
  • No appreciable difference between the dual-probe Cyberwand and the standard ultrasonic Olympus LUS-II lithotrites can be identified.
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Krambeck
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Miller
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Mitchell R
authors.initials: MR
authors.lastname: Humphreys
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Stephen Y
authors.initials: SY
authors.lastname: Nakada
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: John D
authors.initials: JD
authors.lastname: Denstedt
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Hassan
authors.initials: H
authors.lastname: Razvi
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Preminger
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nadler
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Brian R
authors.initials: BR
authors.lastname: Matlaga
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Ryan F
authors.initials: RF
authors.lastname: Paterson
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Ben H
authors.initials: BH
authors.lastname: Chew
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Larry C
authors.initials: LC
authors.lastname: Munch
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: Shelly E
authors.initials: SE
authors.lastname: Handa
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, Vanderbilt University Medical Center, Nashville, TNMayo Clinic, Scottsdale, AZUniversity of Wisconsin School of Medicine, Madison, WIDuke University Medical Center, Durham, NCNorthwestern University Medical School, Chicago, ILJohns Hopkins School of Medicine, Baltimore, MD, USAThe University of Western Ontario, London, OntarioUniversity of British Columbia, Vancouver, Canada.
authors.forename: James E
authors.initials: JE
authors.lastname: Lingeman
mesh_terms: D000328:Adult; D000368:Aged; D004812:Epidemiologic Methods; D004867:Equipment Design; D004868:Equipment Failure; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009403:Nephrostomy, Percutaneous / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D011183:Postoperative Complications / Q000209:etiology; D055815:Young Adult