title: Early onset adenovirus infection after simultaneous kidney-pancreas transplant.
abstract: Adenoviruses (AdV) are increasingly recognized as important viral pathogens in immunocompromised hosts. The clinical spectrum ranges from asymptomatic viremia to allograft dysfunction, and death. Most of the medical literature is on AdV infection in children and bone marrow transplant recipients. We report a case of AdV in an adult recipient in the first month after simultaneous kidney-pancreas transplant with thymoglobulin induction. This is a rare report of adenovirus infection after multiorgan transplant, and is unique in that it exhibited tissue invasive disease without any localizing signs or allograft dysfunction, while other cases in medical literature had invasive disease of the allograft with allograft dysfunction, failure, or death. In addition, this is the first report of a radiologic presentation of AdV nephritis.
authors.affiliation: Department of Surgery, Division of Transplant Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: M C
authors.initials: MC
authors.lastname: Varma
authors.forename: Y B
authors.initials: YB
authors.lastname: Kushner
authors.forename: D S
authors.initials: DS
authors.lastname: Ko
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.forename: P N
authors.initials: PN
authors.lastname: Martins
authors.forename: P
authors.initials: P
authors.lastname: Martins
authors.forename: P
authors.initials: P
authors.lastname: Kaur
authors.forename: J F
authors.initials: JF
authors.lastname: Markmann
authors.forename: C N
authors.initials: CN
authors.lastname: Kotton
mesh_terms: D000256:Adenoviridae / Q000472:pathogenicity*; D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications; D011379:Prognosis