title: The fetal safety of hydrocortisone-pramoxine (Proctofoam-HC) for the treatment of hemorrhoids in late pregnancy.
abstract: OBJECTIVE
  Fetal safety has never been studied for any drug used in the treatment of hemorrhoids. Proctofoam-HC is a combination of a corticosteroid and a local anaesthetic that is proven effective for the treatment of hemorrhoids. The objective of this study was to assess prospectively the fetal safety of third trimester exposure to Proctofoam-HC.
  
  
  METHODS
  In a multicentre study, 204 [corrected] women exposed to Proctofoam-HC in the third trimester and a similar number of control pregnant women were followed up postnatally.
  
  
  RESULTS
  When compared to controls exposure to Proctofoam-HC was not associated with any adverse fetal effects on birth weight, gestational age, rates of prematurity, or pre- or postnatal complications.
  
  
  CONCLUSIONS
  Proctofoam-HC is safe to use in the treatment of hemorrhoids in late pregnancy.
authors.affiliation: Motherisk Program, Hospital for Sick Children Toronto ON.
authors.forename: Neda
authors.initials: N
authors.lastname: Ebrahimi
authors.affiliation: Motherisk Program, Hospital for Sick Children Toronto ON.
authors.forename: Sabina
authors.initials: S
authors.lastname: Vohra
authors.affiliation: Motherisk Program, Hospital for Sick Children Toronto ON.
authors.forename: Christelle
authors.initials: C
authors.lastname: Gedeon
authors.affiliation: Sunnybrook Health Sciences Centre, Toronto ON.
authors.forename: Hani
authors.initials: H
authors.lastname: Akoury
authors.affiliation: Mount Sinai Hospital, Toronto ON.
authors.forename: Paul
authors.initials: P
authors.lastname: Bernstein
authors.affiliation: North York General Hospital, Toronto ON.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Pairaudeau
authors.affiliation: LaSalle Clinic Montreal QC.
authors.forename: Johanne
authors.initials: J
authors.lastname: Cormier
authors.affiliation: LaSalle Clinic Montreal QC.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Dontigny
authors.affiliation: LaSalle Clinic Montreal QC.
authors.forename: Marc-Yvon
authors.initials: MY
authors.lastname: Arsenault
authors.affiliation: LaSalle Clinic Montreal QC.
authors.forename: Claude
authors.initials: C
authors.lastname: Fortin
authors.affiliation: LaSalle Clinic Montreal QC.
authors.forename: Martine
authors.initials: M
authors.lastname: Goyet
authors.affiliation: LaSalle Clinic Montreal QC.
authors.forename: Chantal
authors.initials: C
authors.lastname: Lafortune
authors.affiliation: LaSalle Clinic Montreal QC.
authors.forename: Johanne
authors.initials: J
authors.lastname: Lalande
authors.affiliation: LaSalle Clinic Montreal QC.
authors.forename: Coralie
authors.initials: C
authors.lastname: Beauchamp
authors.affiliation: LaSalle Clinic Montreal QC.
authors.forename: Francis
authors.initials: F
authors.lastname: Engel
authors.affiliation: LaSalle Clinic Montreal QC.
authors.forename: Anne
authors.initials: A
authors.lastname: Fortin
authors.affiliation: Motherisk Program, Hospital for Sick Children Toronto ON.
authors.forename: Anna
authors.initials: A
authors.lastname: Taddio
authors.affiliation: Motherisk Program, Hospital for Sick Children Toronto ON.
authors.forename: Tom
authors.initials: T
authors.lastname: Einarson
authors.affiliation: Motherisk Program, Hospital for Sick Children Toronto ON.
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001724:Birth Weight; D004338:Drug Combinations; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D006484:Hemorrhoids / Q000188:drug therapy*; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects*; D009025:Morpholines / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011263:Pregnancy Trimester, Third
chemical_list: D000779:Anesthetics, Local; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D009025:Morpholines; C009046:proctofoam-HC; D006854:Hydrocortisone