title: Formal synthesis of nitidine and NK109 via palladium-catalyzed domino direct arylation/N-arylation of aryl triflates.
abstract: The use of aryl triflates as reaction partners in a palladium-catalyzed domino direct arylation/N-arylation provides a great advantage due to the availability of starting materials. Furthermore, it allows expedient access to biologically interesting benzo[c]phenanthridine alkaloids.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada, M5S 3H6.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Blanchot
authors.forename: David A
authors.initials: DA
authors.lastname: Candito
authors.forename: Florent
authors.initials: F
authors.lastname: Larnaud
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D053119:Benzophenanthridines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D053119:Benzophenanthridines; D008698:Mesylates; C108284:NK 109; D010165:Palladium; C013615:nitidine