title: Comparison of lipid emulsions on antioxidant capacity in preterm infants receiving parenteral nutrition.
abstract: BACKGROUND
  Although a variety of different lipid emulsions with varying fatty acid contents have been developed, there are some concerns about the administration of these lipid emulsions because of potential adverse effects, including oxidative stress-related morbidity. The aim of the present study was to evaluate and compare the effects of the standard soybean oil-based and olive oil-based i.v. lipid emulsions (ILE) on oxidative stress, determined by total antioxidant capacity (TAC), and to investigate the safety of the use of these two emulsions in terms of biochemical indices.
  
  
  METHODS
  In this prospective study, premature infants were randomly assigned to two groups, each group consisting of 32 patients who received parenteral ILE of either 20% olive oil or 20% soybean oil. They were given ILE for 7 days and then were evaluated with regard to TAC.
  
  
  RESULTS
  No statistically significant difference was observed between the groups in terms of routine biochemical parameters. TAC for both groups on day 7 was significantly lower compared with that on day 0. Although the decrease in TAC within 7 days of ILE administration was greater in the soybean group compared with that in the olive oil group, it was not statistically significant.
  
  
  CONCLUSIONS
  Olive oil-based ILE exhibit similar antioxidant activity and can be used as an alternative to soybean oil-based ILE. TAC significantly decreased in infants following administration of either lipid emulsion, and premature infants tolerated either ILE well, both biochemically and clinically.
authors.affiliation: Division of Neonatology, Uludag University School of Medicine, Bursa, Turkey.
authors.forename: Nilgün
authors.initials: N
authors.lastname: Köksal
authors.forename: Ahmet V
authors.initials: AV
authors.lastname: Kavurt
authors.forename: Merih
authors.initials: M
authors.lastname: Cetinkaya
authors.forename: Yesim
authors.initials: Y
authors.lastname: Ozarda
authors.forename: Hilal
authors.initials: H
authors.lastname: Ozkan
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D004311:Double-Blind Method; D005217:Fat Emulsions, Intravenous / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D007235:Infant, Premature, Diseases; D008297:Male; D000069463:Olive Oil; D018384:Oxidative Stress / Q000187:drug effects*; D010288:Parenteral Nutrition; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D011446:Prospective Studies; D013024:Soybean Oil / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005217:Fat Emulsions, Intravenous; D000069463:Olive Oil; D010938:Plant Oils; D013024:Soybean Oil