title: Eurasian and Sub-Saharan African mitochondrial DNA haplogroup influences pseudoexfoliation glaucoma development in Saudi patients.
abstract: OBJECTIVE
  To investigate whether different mitochondrial DNA (mtDNA) haplogroups have a role on the development of pseudoexfoliation glaucoma (PEG) in the Saudi Arab population.
  
  
  METHODS
  The mtDNA regulatory region and coding regions comprising mtDNA haplogroup diagnostic polymorphisms were sequenced in patients with PEG (n=94), healthy matched controls (free of PEG; n=112) and a healthy Saudi Arab population group (n=810).
  
  
  RESULTS
  The Eurasian haplogroup T and the Sub-Saharan African Haplogroup L2 confer susceptibility to PEG, whereas the Eurasian haplogroup N1 was associated with reduced risk to develop PEG in the Saudi Arab population.
  
  
  CONCLUSIONS
  Mitochondrial haplogroups T and L2 may play a role in the development of PEG in the Saudi Arabian population.
authors.affiliation: Ophthalmic Genetics Laboratory, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. abuamero@gmail.com
authors.forename: Khaled K
authors.initials: KK
authors.lastname: Abu-Amero
authors.forename: Vicente M
authors.initials: VM
authors.lastname: Cabrera
authors.forename: José M
authors.initials: JM
authors.lastname: Larruga
authors.forename: Essam A
authors.initials: EA
authors.lastname: Osman
authors.forename: Ana M
authors.initials: AM
authors.lastname: González
authors.forename: Saleh A
authors.initials: SA
authors.lastname: Al-Obeidan
mesh_terms: D017954:Africa South of the Sahara; D044383:Black People / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005060:Europe; D017889:Exfoliation Syndrome / Q000150:complications* / Q000235:genetics*; D005901:Glaucoma / Q000150:complications* / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D012529:Saudi Arabia
chemical_list: D004272:DNA, Mitochondrial