title: Views of immunology: effector T cells.
abstract: For many intracellular bacteria, both adaptively acquired and innately encoded effector T cells play a central role in the control, and in some cases, clearance of these pathogens. Through the rapid identification of those cells harboring intracellular bacteria, effector T cells have the capacity to both directly control the infection and shape the immune response to the pathogen. Here, we review the mechanisms by which effector T cells control intracellular infection and emphasize the means by which they recognize their targets. As will become evident, the diversity of both redundant and non-redundant effector mechanisms in conjunction with broad recognition of both protein and non-protein antigens allows for the identification of a broad array of bacterial pathogens and lessens the likelihood of immune evasion.
authors.affiliation: Pediatric Infectious Diseases, Oregon Health & Science University, Portland, OR, USA. lewinsod@ohsu.edu
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Lewinsohn
authors.forename: Marielle C
authors.initials: MC
authors.lastname: Gold
authors.forename: David M
authors.initials: DM
authors.lastname: Lewinsohn
mesh_terms: D017951:Antigen Presentation; D003141:Communicable Diseases / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*