title: Computed tomographic assessment of lung weights in trauma patients with early posttraumatic lung dysfunction.
abstract: BACKGROUND
  Quantitative computed tomography (qCT)-based assessment of total lung weight (Mlung) has the potential to differentiate atelectasis from consolidation and could thus provide valuable information for managing trauma patients fulfilling commonly used criteria for acute lung injury (ALI). We hypothesized that qCT would identify atelectasis as a frequent mimic of early posttraumatic ALI.
  
  
  METHODS
  In this prospective observational study, Mlung was calculated by qCT in 78 mechanically ventilated trauma patients fulfilling the ALI criteria at admission. A reference interval for Mlung was derived from 74 trauma patients with morphologically and functionally normal lungs (reference). Results are given as medians with interquartile ranges.
  
  
  RESULTS
  The ratio of arterial partial pressure of oxygen to the fraction of inspired oxygen was 560 (506 to 616) mmHg in reference patients and 169 (95 to 240) mmHg in ALI patients. The median reference Mlung value was 885 (771 to 973) g, and the reference interval for Mlung was 584 to 1164 g, which matched that of previous reports. Despite the significantly greater median Mlung value (1088 (862 to 1,342) g) in the ALI group, 46 (59%) ALI patients had Mlung values within the reference interval and thus most likely had atelectasis. In only 17 patients (22%), Mlung was increased to the range previously reported for ALI patients and compatible with lung consolidation. Statistically significant differences between atelectasis and consolidation patients were found for age, Lung Injury Score, Glasgow Coma Scale score, total lung volume, mass of the nonaerated lung compartment, ventilator-free days and intensive care unit-free days.
  
  
  CONCLUSIONS
  Atelectasis is a frequent cause of early posttraumatic lung dysfunction. Differentiation between atelectasis and consolidation from other causes of lung damage by using qCT may help to identify patients who could benefit from management strategies such as damage control surgery and lung-protective mechanical ventilation that focus on the prevention of pulmonary complications.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, University Hospital Leipzig, Liebigstrasse 20, D-04103 Leipzig, Germany. andreas.reske@medizin.uni-leipzig.de
authors.forename: Andreas W
authors.initials: AW
authors.lastname: Reske
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Reske
authors.forename: Till
authors.initials: T
authors.lastname: Heine
authors.forename: Peter M
authors.initials: PM
authors.lastname: Spieth
authors.forename: Anna
authors.initials: A
authors.lastname: Rau
authors.forename: Matthias
authors.initials: M
authors.lastname: Seiwerts
authors.forename: Harald
authors.initials: H
authors.lastname: Busse
authors.forename: Udo
authors.initials: U
authors.lastname: Gottschaldt
authors.forename: Dierk
authors.initials: D
authors.lastname: Schreiter
authors.forename: Silvia
authors.initials: S
authors.lastname: Born
authors.forename: Marcelo
authors.initials: M
authors.lastname: Gama de Abreu
authors.forename: Christoph
authors.initials: C
authors.lastname: Josten
authors.forename: Hermann
authors.initials: H
authors.lastname: Wrigge
authors.forename: Marcelo B P
authors.initials: MB
authors.lastname: Amato
mesh_terms: D055371:Acute Lung Injury / Q000000981:diagnostic imaging* / Q000473:pathology*; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008168:Lung / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011446:Prospective Studies; D001261:Pulmonary Atelectasis / Q000000981:diagnostic imaging*; D012016:Reference Values; D012121:Respiration, Artificial; D014057:Tomography, X-Ray Computed; D055815:Young Adult