title: Comparison of major immunoglobulins intrathecal synthesis patterns in Ecuadorian and Cuban patients with angiostrongyliasis.
abstract: Angiostrongylus cantonensis meningitis was first reported in Cuba in 1981, and it was recently reported in South America. The aim of this paper is to evaluate the intrathecal immunoglobulin synthesis patterns from Cuba's and Ecuador's patients with angiostrongyliasis; 8 Ecuadorian patients from two different outbreaks and 28 Cuban patients were studied. Simultaneous blood and cerebrospinal fluid samples were taken. Immunoglobulin (Ig) A, IgM, IgG, and albumin were quantified by radial immunodiffusion. Corresponding Reibergrams were applied. A three-Ig pattern was the most frequent in the two groups, but IgM was presented in all Ecuadorian young mature patients; however, in the Cuban children, only 12 of 28 patients had intrathecal IgM, but about 90% had an IgA and IgG synthesis at time of later puncture. This indicates that, with a larger amount of parasites ingested, clinical symptoms are more severe, and a higher frequency of intrathecal IgM synthesis could be observed. This is discussed as a similarity with the intrathecal IgM synthesis in African trypanosomiasis.
authors.affiliation: Laboratorio Central de Líquido Cefalorraquídeo (LABCEL), Facultad de Ciencias Médicas Dr. Miguel Enríquez, Universidad de Ciencias Médicas de La Habana, Havana, Cuba. barbara.padilla@infomed.sld.cu
authors.forename: Bárbara
authors.initials: B
authors.lastname: Padilla-Docal
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: Dorta-Contreras
authors.forename: Juan M
authors.initials: JM
authors.lastname: Moreira
authors.forename: Luiggi
authors.initials: L
authors.lastname: Martini-Robles
authors.forename: Jenny
authors.initials: J
authors.lastname: Muzzio-Aroca
authors.forename: Fernando
authors.initials: F
authors.lastname: Alarcón
authors.forename: María Esther
authors.initials: ME
authors.lastname: Magraner-Tarrau
authors.forename: Raisa
authors.initials: R
authors.lastname: Bu-Coifiu-Fanego
mesh_terms: D002648:Child; D002675:Child, Preschool; D003462:Cuba / Q000453:epidemiology; D004484:Ecuador / Q000453:epidemiology; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid* / Q000378:metabolism; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology*; D017206:Strongylida Infections / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism; D055815:Young Adult
chemical_list: D007136:Immunoglobulins