title: No association between telomere length in peripheral blood leukocytes and the risk of nonmelanoma skin cancer.
abstract: BACKGROUND
  Recent reports have shown that telomere length was associated with the risk of various cancers, but the results have been inconsistent.
  
  
  METHODS
  We prospectively evaluated the association of telomere length in peripheral blood leukocytes with the risk of skin squamous cell carcinoma (SCC) in 241 cases and 241 controls within the Health Professionals Follow-up Study (HPFS), and the risk of skin basal cell carcinoma (BCC) in 623 cases and 1,943 controls within the Nurses' Health Study (NHS).
  
  
  RESULTS
  No significant association was observed between telomere length and risk of SCC (longest quartile vs. shortest quartile, OR = 1.09, 95%CI: 0.62-1.93, P = 0.81). Null findings were also observed between telomere length and risk of BCC in 2 independent sets (OR = 0.96, 95%CI: 0.49-1.87, P = 0.83; and OR = 0.91, 95%CI: 0.66-1.25, P = 0.39).
  
  
  CONCLUSIONS
  We found no evidence that telomere length in peripheral blood leukocytes was associated with risk of nonmelanoma skin cancer.
  
  
  CONCLUSIONS
  Our prospective study suggests that telomere length in peripheral blood leukocytes is less likely to play a substantial role in nonmelanoma skin cancer development.
authors.affiliation: Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Geyu
authors.initials: G
authors.lastname: Liang
authors.forename: Abrar A
authors.initials: AA
authors.lastname: Qureshi
authors.forename: Qun
authors.initials: Q
authors.lastname: Guo
authors.forename: Immaculata
authors.initials: I
authors.lastname: De Vivo
authors.forename: Jiali
authors.initials: J
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D002280:Basal Cell Carcinoma / Q000097:blood / Q000209:etiology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D015331:Cohort Studies; D004273:DNA, Neoplasm / Q000097:blood / Q000235:genetics; D005500:Follow-Up Studies; D006801:Humans; D007962:Leukocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009726:Nurses / Q000706:statistics & numerical data; D016133:Polymerase Chain Reaction; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000097:blood / Q000209:etiology* / Q000473:pathology; D016615:Telomere / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm