title: The ups and downs of tannins as inhibitors of poly(ADP-ribose)glycohydrolase.
abstract: DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.
authors.affiliation: Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Winterthurerstrasse 260, 8057 Zurich, Switzerland. blennc@vetpharm.uzh.ch
authors.forename: Christian
authors.initials: C
authors.lastname: Blenn
authors.forename: Philippe
authors.initials: P
authors.lastname: Wyrsch
authors.forename: Felix R
authors.initials: FR
authors.lastname: Althaus
mesh_terms: D000818:Animals; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D011064:Poly Adenosine Diphosphate Ribose / Q000737:chemistry / Q000378:metabolism; D034622:RNA Interference; D013634:Tannins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D013634:Tannins; D011064:Poly Adenosine Diphosphate Ribose; D006026:Glycoside Hydrolases; C022407:poly ADP-ribose glycohydrolase