title: Nonterpenoid C15 acetogenins from Laurencia marilzae.
abstract: Eight new halogenated C(15) acetogenins, 1-8, were isolated from the organic extract of the red alga Laurencia marilzae. The structure elucidation and the assignments of the relative configurations were established by extensive use of spectroscopic studies, particularly 1D and 2D NMR data, while the absolute configurations of compounds 1 and 5 were determined by single-crystal X-ray diffraction analysis. Compounds 1, 2, 4, 5, and 7, along with the previously reported related cyclic ether obtusallene IV (9), were evaluated against six human solid tumor cell lines. All compounds were found to be essentially inactive (GI(50) > 10 μg/mL).
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
authors.forename: Adrián
authors.initials: A
authors.lastname: Gutiérrez-Cepeda
authors.forename: José J
authors.initials: JJ
authors.lastname: Fernández
authors.forename: Laura V
authors.initials: LV
authors.lastname: Gil
authors.forename: Matías
authors.initials: M
authors.lastname: López-Rodríguez
authors.forename: Manuel
authors.initials: M
authors.lastname: Norte
authors.forename: María L
authors.initials: ML
authors.lastname: Souto
mesh_terms: D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D044722:Laurencia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D054378:Acetogenins; D000970:Antineoplastic Agents