title: Regulation of hepatocyte fate by interferon-γ.
abstract: Interferon (IFN)-γ is a cytokine known for its immunomodulatory and anti-proliferative action. In the liver, IFN-γ can induce hepatocyte apoptosis or inhibit hepatocyte cell cycle progression. This article reviews recent mechanistic reports that describe how IFN-γ may direct the fate of hepatocytes either towards apoptosis or a cell cycle arrest. This review also describes a probable role for IFN-γ in modulating hepatocyte fate during liver regeneration, transplantation, hepatitis, fibrosis and hepatocellular carcinoma, and highlights promising areas of research that may lead to the development of IFN-γ as a therapy to enhance recovery from liver disease.
authors.affiliation: Department of Biological Sciences, Boise State University, 1910 University Drive, Boise, ID 83725-1515, United States.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Horras
authors.forename: Cheri L
authors.initials: CL
authors.lastname: Lamb
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Mitchell
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects* / Q000235:genetics; D049109:Cell Proliferation / Q000187:drug effects; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D008107:Liver Diseases / Q000235:genetics / Q000473:pathology / Q000628:therapy; D008115:Liver Regeneration / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D016031:Liver Transplantation / Q000379:methods / Q000502:physiology; D008954:Models, Biological
chemical_list: D007371:Interferon-gamma