title: The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE).
abstract: Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovine β-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera of infants with apparent life threatening events (ALTE syndromes, 'near miss SIDS'). We have found that the sera of some infants after an apnoea event contained more β-casomorphin-7 than that of the healthy infants in the same age. In all the children after an apnoea event, however, a lowered DPPIV was detected. We suspect that the low activity of that peptidase may be responsible for opioid-induced respiratory depression, induced by bBCM-7 in the general circulation.
authors.affiliation: Department of Paediatrics, Gastroenterology and Allergic Diseases, The Medical University of Białystok, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Wasilewska
authors.forename: Edyta
authors.initials: E
authors.lastname: Sienkiewicz-Szłapka
authors.forename: Ewa
authors.initials: E
authors.lastname: Kuźbida
authors.forename: Beata
authors.initials: B
authors.lastname: Jarmołowska
authors.forename: Maciej
authors.initials: M
authors.lastname: Kaczmarski
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Kostyra
mesh_terms: D000818:Animals; D001049:Apnea / Q000097:blood*; D002417:Cattle; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D004723:Endorphins / Q000097:blood*; D006801:Humans; D007223:Infant; D018847:Opioid Peptides / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D013398:Sudden Infant Death
chemical_list: D004723:Endorphins; D018847:Opioid Peptides; D010446:Peptide Fragments; C041128:beta-casomorphin 7; D018819:Dipeptidyl Peptidase 4