title: The RHINASTHMA GAV scores without SLIT, at the beginning and at the end of seasonal SLIT.
abstract: BACKGROUND
  The impact of treatments for allergic rhinitis on health-related quality of life (HRQL) becomes more and more important in the view of patients, physicians and payers, but not much is known about the effect of sublingual immunotherapy (SLIT) on this outcome parameter.
  
  
  METHODS
  In a prospective observational study, health-related quality of life was assessed with the German adapted version of a new specific questionnaire (RHINASTHMA GAV) in patients with allergic rhinitis with or without mild to moderate asthma due to grass, cereal, and/or rye pollen who were treated with seasonal high-dose SLIT with standardized allergen extracts.
  
  
  RESULTS
  358 patients aged 5 - 68 years, mean +/- SD disease duration of 8.8 +/- 9.2 years were evaluated. During SLIT, the mean total score and all 5 mean sub-scale scores were substantially reduced by 36% to 55%. Subgroup analyses did not reveal any clinically relevant deviations from the results in the total study population. At the end of SLIT, mean total score and sub-scale scores were virtually identical to those scores assessed during the validation procedure of RHINASTHMA GAV in healthy subjects without rhinitis, conjunctivitis, or asthma. These improvements in HRQL during SLIT were paralleled by substantially reduced disease-related burden, in terms of symptom scores and health-related impairment in daily life and at work.
  
  
  CONCLUSIONS
  The improvement in HRQL during seasonal SLIT was clinically relevant and reached scores close to normal already in the first pollen season.
authors.affiliation: Stallergènes, Kamp-Lintfort, Germany. HSieber@stallergenes.de
authors.forename: Jochen
authors.initials: J
authors.lastname: Sieber
authors.forename: Anna
authors.initials: A
authors.lastname: Gross
authors.forename: Kija
authors.initials: K
authors.lastname: Shah-Hosseini
authors.forename: Ralph
authors.initials: R
authors.lastname: Mösges
mesh_terms: D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000009:adverse effects / Q000276:immunology; D001249:Asthma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D011058:Pollen / Q000009:adverse effects; D011788:Quality of Life; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D011795:Surveys and Questionnaires
chemical_list: D000485:Allergens