title: Sequence complementarity-driven nonenzymatic ligation of RNA.
abstract: We report two reactions of RNA G:C sequences occurring nonenzymatically in water in the absence of any added cofactor or metal ion: (a) sequence complementarity-driven terminal ligation and (b) complementary sequence adaptor-driven multiple tandemization. The two abiotic reactions increase the chemical complexity of the resulting pool of RNA molecules and change the Shannon information of the initial population of sequences.
authors.affiliation: Dipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Università di Roma, P.le Aldo Moro, 5, Rome 00185, Italy.
authors.forename: Samanta
authors.initials: S
authors.lastname: Pino
authors.forename: Giovanna
authors.initials: G
authors.lastname: Costanzo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Giorgi
authors.forename: Ernesto
authors.initials: E
authors.lastname: Di Mauro
mesh_terms: D020029:Base Pairing; D001483:Base Sequence; D000242:Cyclic AMP / Q000737:chemistry; D006152:Cyclic GMP / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides / Q000737:chemistry* / Q000235:genetics; D012313:RNA / Q000737:chemistry* / Q000235:genetics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014867:Water / Q000737:chemistry
chemical_list: D009843:Oligoribonucleotides; D014867:Water; D012313:RNA; D000242:Cyclic AMP; D006152:Cyclic GMP