title: Differential diagnosis of basal cell carcinoma and benign tumors of cutaneous appendages originating from hair follicles by using CD34.
abstract: OBJECTIVE
  Differential diagnosis of the group of benign trichoblastomas, trichofolliculomas, trichoadenomas and trichoepitheliomas, and basal cell carcinomas (BCCs) is troublesome for the clinician as well as the pathologist, especially when only small biopsy specimens are available. Here we investigated whether CD34 expression might be of assistance.
  
  
  METHODS
  Thirty benign tumors of cutaneous appendages originating from hair follicles (BTCOHF) and 30 BCCs were retrieved from our archives and immunohistochemically stained. CD 34 expression was graded from [0] to [2+] and compared among the groups and subgroups.
  
  
  RESULTS
  There was no significant difference between the degree of expression between [0] and [1+] and [0] and [2+] for each group. However, [1+] and [2+] immunopositivity of BTCOHFs was significantly stronger than in BCCs (p= 0.014).
  
  
  CONCLUSIONS
  CD34 may contribute to differential diagnosis of skin lesions.
authors.affiliation: Department of Pathology, Prof. Dr. A. Ilhan Ozdemir State Hospital, Turkey.
authors.forename: Demet
authors.initials: D
authors.lastname: Sengul
authors.forename: Ilker
authors.initials: I
authors.lastname: Sengul
authors.forename: Muzeyyen Hesna
authors.initials: MH
authors.lastname: Astarci
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ustun
authors.forename: Gamze
authors.initials: G
authors.lastname: Mocan
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018280:Carcinoma, Skin Appendage / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006201:Hair Diseases / Q000175:diagnosis* / Q000378:metabolism; D018859:Hair Follicle / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D018295:Neoplasms, Basal Cell / Q000175:diagnosis* / Q000378:metabolism; D011379:Prognosis; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor