title: Scalarane sesterterpenes from the sponge Hyatella sp.
abstract: Five new sesterterpenes (7-11) along with six known compounds (1-6) were isolated from the sponge Hyatella sp., collected off the coast of Soheuksan-do, Korea. Spectroscopic analyses revealed these compounds as scalarane sesterterpenes with oxidized furan moieties (7-10) and a corresponding lactam (11). The compounds exhibited moderate cytotoxicity, antibacterial activity, and weak inhibitory activity against isocitrate lyase.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Ju-eun
authors.initials: JE
authors.lastname: Jeon
authors.forename: Jaemin
authors.initials: J
authors.lastname: Bae
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Lee
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D056911:Democratic People's Republic of Korea; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors; D008826:Microbial Sensitivity Tests; D008837:Micrococcus / Q000187:drug effects; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011514:Proteus vulgaris / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D054830:Sesterterpenes; D007522:Isocitrate Lyase