title: Effects of exercise and zinc supplementation on cytokine release in young wrestlers.
abstract: The present study aims to examine the effect of zinc supplementation on the release of some cytokines in young wrestlers actively involved in wrestling. A total of 40 male subjects of the same age group were included in the study: half were wrestlers and the other half were not involved in sports. The subjects were equally divided into four groups and treated during an 8-week period as follows: group 1, zinc-supplemented athletes; group 2, non-supplemented athletes; group 3, zinc-supplemented sedentary subjects, and group 4, non-supplemented sedentary group. Blood samples were taken from each subject at the beginning and at the end of the study period. The serum tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), and interpheron-γ levels (IFN-γ) were determined using the enzyme-linked immunosorbent assay method. At the beginning of the study, there were no significant differences of the measured parameters between the four study groups. At the end of the study, the levels of TNF-α, IL-2, and IFN-γ were significantly higher in the two zinc-supplemented groups compared to those that did not receive supplementation, regardless of the activity status (p < 0.01).
authors.affiliation: Hasan Dogan High School of Physical Education and Sports, Karabuk University, Karabuk, Turkey. kara.ersan@yahoo.com
authors.forename: Ersan
authors.initials: E
authors.lastname: Kara
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozal
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gunay
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kilic
authors.forename: Abdulkerim Kasim
authors.initials: AK
authors.lastname: Baltaci
authors.forename: Rasim
authors.initials: R
authors.lastname: Mogulkoc
mesh_terms: D000293:Adolescent; D016207:Cytokines / Q000378:metabolism*; D019587:Dietary Supplements; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014952:Wrestling; D015032:Zinc / Q000008:administration & dosage*
chemical_list: D016207:Cytokines; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D015032:Zinc