title: [Study on the second metabolisms from fungus HS-1 Epicoccum spp. from the sea cucumber in Yellow Sea].
abstract: OBJECTIVE
  To get active metabolites from the microbes associated with sea cucumber.
  
  
  METHODS
  Fungus was isolated from the sea cucumber, and the species was identified by molecular biology, and then was cultivated in GYP medium, and the metabolites were got by chromatography. Their structures were identified by comprehensive spectroscopic methods.
  
  
  RESULTS
  Fungus HS-1 Epicocum sp. was isolated from the sea cucumber in Weihai, Yellow Sea. Four compounds were got as 5-methyl-6-hydroxy-8-methyoxy-3-methylisochroman (1), 8-hydroxy-3-methylisochroman-1-one (2), peroxy-ergosterol (3) and succinic acid (4).
  
  
  CONCLUSIONS
  Fungus HS-1 Epicocum spp. is first isolated from the sea cucumber sample, this research provides new idea for further development of sea cucumber.
authors.affiliation: Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, China.
authors.forename: Xue-Kui
authors.initials: XK
authors.lastname: Xia
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Zhang
authors.forename: Wen-Peng
authors.initials: WP
authors.lastname: Yuan
authors.forename: Mian-Song
authors.initials: MS
authors.lastname: Zhang
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Wang
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Meng
authors.forename: Chang-Heng
authors.initials: CH
authors.lastname: Liu
mesh_terms: D000818:Animals; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification; D005658:Fungi / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D008386:Marine Biology; D015394:Molecular Structure; D010675:Pheromones / Q000737:chemistry / Q000302:isolation & purification*; D012616:Sea Cucumbers / Q000382:microbiology*; D019802:Succinic Acid / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D010675:Pheromones; D019802:Succinic Acid; D004875:Ergosterol