title: Empirical treatment with pantoprazole as a diagnostic tool for symptomatic adult laryngopharyngeal reflux.
abstract: OBJECTIVE
  To determine the sensitivity and specificity of intensive empirical treatment with pantoprazole in diagnosing laryngopharyngeal reflux in adults.
  
  
  METHODS
  This was a prospective, double-blind study.
  
  
  METHODS
  Fifty-five patients with either a Reflux Symptom Index of more than 13 or a Reflux Finding Score of more than 7 were enrolled. All patients underwent 24-hour, double-probe pH monitoring before commencing pantoprazole 40 mg twice daily; both investigators and patients were blinded to pH monitoring results. The Reflux Symptom Index and Reflux Finding Score were reassessed during the second, third and fourth month of follow up.
  
  
  RESULTS
  The sensitivity of empirical pantoprazole treatment in diagnosing laryngopharyngeal reflux was 92.5 per cent. The specificity was 14.2 per cent, the positive predictive value 86 per cent and the negative predictive value 25 per cent. There was significant reduction in the total Reflux Symptom Index and Reflux Finding Score after the second, third and fourth month of treatment. There was no correlation between laryngopharyngeal reflux and body mass index.
  
  
  CONCLUSIONS
  Our results suggest that intensive empirical treatment with proton pump inhibitors is effective in diagnosing laryngopharyngeal reflux.
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Hospital Sultanah Bahiyah, Alor Setar, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Masaany
authors.forename: M B
authors.initials: MB
authors.lastname: Marina
authors.forename: W P
authors.initials: WP
authors.lastname: Sharifa Ezat
authors.forename: A
authors.initials: A
authors.lastname: Sani
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D004311:Double-Blind Method; D016099:Endoscopy, Gastrointestinal; D050782:Esophageal pH Monitoring / Q000009:adverse effects* / Q000295:instrumentation; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D008296:Malaysia / Q000453:epidemiology; D008875:Middle Aged; D010146:Pain / Q000453:epidemiology / Q000209:etiology; D010147:Pain Measurement / Q000379:methods; D000077402:Pantoprazole; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D054328:Proton Pump Inhibitors; D000077402:Pantoprazole