title: [Kidney transplant from living donors in children?].
abstract: A living-donor kidney transplant offers a child at the terminal stages of renal disease better functional recovery and quality of life than an organ from a deceased donor. Before starting the procedure for a living-donor transplant, however, it is necessary to establish if it is really safe. There are diseases, such as focal segmental glomerulosclerosis, atypical HUS and membranoproliferative glomerulonephritis with dense deposits, for which living donation is not recommended given the high incidence of recurrence of the disease but also the frequent loss of the graft. Regarding the selection of the donor, an increased risk of acute rejection has been reported for donors older than 60-65 years and a worsening of the renal outcome if the donor's weight is equal to or less than the recipient's. Finally, it is necessary to take into consideration that complications may arise in the donor both in the perioperative period and in the long term. In conclusion, kidney transplant from a living donor is a natural choice within the pediatric setting. The parents, usually young and highly motivated to donate, are the ideal donors. However, although the risks associated with donation are minimal, they are not totally absent, and consequently it is mandatory to follow standardized procedures according to the guidelines issued by the Centro Nazionale Trapianti.
authors.affiliation: Medicina Clinica e Sperimentale dei Trapianti, U.O.C. Nefrologia, Istituto G. Gaslini, Genova, Italy. fabrizioginevri@ospedale-gaslini.ge.it
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ginevri
authors.forename: Luca
authors.initials: L
authors.lastname: Dello Strologo
authors.forename: Isabella
authors.initials: I
authors.lastname: Guzzo
authors.forename: Mirco
authors.initials: M
authors.lastname: Belingheri
authors.forename: Luciana
authors.initials: L
authors.lastname: Ghio
mesh_terms: D002648:Child; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors