title: Anthelmintic activities of chloroform and methanol extracts of Buchholzia coriacea Engler seed.
abstract: The anthelmintic potentials of the chloroform and methanol extracts of Buchholzia coriacea Engler seed were investigated. In folklore medicine, B. coriacea (Capparidaceae) is believed to be useful in the treatment of various kinds of ailments and diseases. At doses of 10 mg/kg, 25 mg/kg and 50 mg/kg, the extracts were tested against Eudrilus eugeniae (earthworm) and Bunostomum phlebotomum (cattle hookworm). The extracts exhibited dose-dependent anthelmintic effects on the earthworms and hookworms. The methanol extract at 50 mg/kg was the most active extract against the helminths, and the activity of the methanol extract was not significantly different from that of piperazine hydrate (reference drug, 10 mg/kg) against the earthworms.
authors.affiliation: Department of Pharmacognosy, Olabisi Onabanjo University, Sagamu, Nigeria. adediwurajaiyesimi@gmail.com
authors.forename: Adediwura A
authors.initials: AA
authors.lastname: Fred-Jaiyesimi
authors.forename: Adeola
authors.initials: A
authors.lastname: Adepoju
authors.forename: Oluwatosin
authors.initials: O
authors.lastname: Egbebunmi
mesh_terms: D000723:Ancylostomatoidea / Q000187:drug effects*; D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification / Q000494:pharmacology*; D031483:Capparaceae / Q000737:chemistry*; D002725:Chloroform / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D009835:Oligochaeta / Q000187:drug effects*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts; D012997:Solvents; D002725:Chloroform; D000432:Methanol