title: Role of TRP channels in the regulation of the endosomal pathway.
abstract: Some members of the transient receptor potential (TRP) channel superfamily have proved to be essential in maintaining adequate ion homeostasis, signaling, and membrane trafficking in the endosomal pathway. The unique properties of the TRP channels confer cells the ability to integrate cytosolic and intraluminal stimuli and allow maintained and regulated release of Ca(2+) from endosomes and lysosomes.
authors.affiliation: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Ken
authors.initials: K
authors.lastname: Abe
authors.forename: Rosa
authors.initials: R
authors.lastname: Puertollano
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D021381:Protein Transport; D015398:Signal Transduction; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
chemical_list: D050051:Transient Receptor Potential Channels; D002118:Calcium