title: Hybrid luminescent/magnetic nanostructured porous silicon particles for biomedical applications.
abstract: This work describes a novel process for the fabrication of hybrid nanostructured particles showing intense tunable photoluminescence and a simultaneous ferromagnetic behavior. The fabrication process involves the synthesis of nanostructured porous silicon (NPSi) by chemical anodization of crystalline silicon and subsequent in pore growth of Co nanoparticles by electrochemically-assisted infiltration. Final particles are obtained by subsequent sonication of the Co-infiltrated NPSi layers and conjugation with poly(ethylene glycol) aiming at enhancing their hydrophilic character. These particles respond to magnetic fields, emit light in the visible when excited in the UV range, and internalize into human mesenchymal stem cells with no apoptosis induction. Furthermore, cytotoxicity in in-vitro systems confirms their biocompatibility and the viability of the cells after incorporation of the particles. The hybrid nanostructured particles might represent powerful research tools as cellular trackers or in cellular therapy since they allow combining two or more properties into a single particle.
authors.affiliation: Universidad Autónoma de Madrid, Centro de Investigaciones Biomédicas en Red: Bioingeniería, Biomateriales y Nanomedicina (CIBER-bbn), Departamento de Física Aplicada, Cantoblanco, Madrid, Spain. alvaro.munnoz@uam.es
authors.forename: Alvaro
authors.initials: A
authors.lastname: Muñoz-Noval
authors.forename: Vanessa
authors.initials: V
authors.lastname: Sánchez-Vaquero
authors.forename: Vicente
authors.initials: V
authors.lastname: Torres-Costa
authors.forename: Darío
authors.initials: D
authors.lastname: Gallach
authors.forename: Vicente
authors.initials: V
authors.lastname: Ferro-Llanos
authors.forename: José Javier
authors.initials: JJ
authors.lastname: Serrano
authors.forename: Miguel
authors.initials: M
authors.lastname: Manso-Silván
authors.forename: Josefa Predestinación
authors.initials: JP
authors.lastname: García-Ruiz
authors.forename: Francisco
authors.initials: F
authors.lastname: del Pozo
authors.forename: Raúl J
authors.initials: RJ
authors.lastname: Martín-Palma
mesh_terms: D001854:Bone Marrow Cells / Q000166:cytology* / Q000187:drug effects / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003287:Contrast Media / Q000633:toxicity; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008163:Luminescent Measurements / Q000379:methods*; D008422:Materials Testing; D008856:Microscopy, Fluorescence / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry / Q000633:toxicity; D016062:Porosity; D012825:Silicon / Q000633:toxicity
chemical_list: D003287:Contrast Media; D012825:Silicon