title: Nasal provocation test: how to maximize its clinical use?
abstract: In order to diagnose allergic rhinitis (AR), skin prick tests and serum specific IgE level are the most common used methods. But there are some conditions which the results of both methods do not correlate with the clinical presentation of AR. Nasal provocation test is the method of detecting local IgE at the shock organ. There are some variations of NPT in terms of dosage, allergen administration, evaluation and scoring system. This article summarized the usefulness of NPT, its indication and contraindication, dosage and instillation techniques for allergens and evaluation of outcome in the hope that if we can standardize the procedure and make it easier to perform, NPT will be applied more in clinical practice. In addition normal values among Asian ethnics are presented for appropriate interpretation of the test.
authors.affiliation: Division of Rhinology Allergy, Department of Otorhinolaryngology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. siptv@mahidol.ac.th
authors.forename: Pongsakorn
authors.initials: P
authors.lastname: Tantilipikorn
authors.forename: Pakit
authors.initials: P
authors.lastname: Vichyanond
authors.forename: Jean Silvain
authors.initials: JS
authors.lastname: Lacroix
mesh_terms: D000281:Administration, Intranasal; D000485:Allergens; D000818:Animals; D001208:Asia; D006801:Humans; D007114:Immunization; D007159:Immunologic Tests / Q000379:methods / Q000592:standards; D044382:Population Groups; D011237:Predictive Value of Tests; D012015:Reference Standards; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology
chemical_list: D000485:Allergens