title: Detection of ErbB Receptor Family Tyrosyl Phosphorylation in Ovarian Carcinoma Cells.
abstract: The epidermal growth factor receptor (EGFR) (ErbB) family of receptor tyrosine kinases is frequently overexpressed in ovarian cancer (1) . This receptor group is comprised of four members, EGFR (ErbB-1), HER2 (ErbB-2), HER3 (ErbB-3), and HER4 (ErbB-4). These receptors share a common molecular architecture, possessing a large glycosylated extracellular ligand-binding domain, a single hydrophobic transmembrane domain, and a cytoplasmic tyrosine kinase domain (2). Amplification and over- expression of ErbB-2 have been reported in ovarian carcinoma, where high levels of ErbB-2 directly correlate with poor clinical prognosis (3,4). Amplification of EGFR has also been reported, and may have prognostic significance (5,6). Less is known about the clinical significance of ErbB-3 (7) and ErbB-4 (8), which have been more recently identified.
authors.affiliation: Division of Cell and Molecular Biology, Greenebaum Center for Cancer Research, University of Maryland, Baltimore, MD.
authors.forename: A W
authors.initials: AW
authors.lastname: Hamburger