title: [Diagnostic efficacy of plasma ACTH-measurement by a chemiluminometric assay in canine hyperadrenocorticism].
abstract: This retrospective study was performed to investigate the diagnostic efficacy of the chemiluminometric ACTH-measurement to differentiate between pituitary and adrenal dependent hyperadrenocorticism (HAC) in dogs. 49 dogs with pituitary HAC, 10 dogs with adrenal HAC and 1 dog with a combination of both pathologies were included. Dogs with HAC like symptoms, where HAC had been ruled out, served as controls (n = 18). All dogs with adrenal HAC, as well as 9 dogs with pituitary HAC had an ACTH concentration below the detection limit of 2.2 pmol/l (10 pg/dl) plasma. Using 2.2 pmol/l as a cut-off the sensitivity and specificity to diagnose pituitary HAC was 0.82 (95 % CI 0.686 - 0.914) and 1 (95 % CI 0.692 - 1), respectively. With the help of the chemiluminometric assay, a correct classification was possible in 85 % of patients with HAC. As an ACTH-concentration below the detection limit was found in dogs with adrenal as well as pituitary HAC, additional discriminatory tests are necessary in these cases.
authors.affiliation: Abteilung Interne Medizin Kleintiere, Veterinärmedizinische Universität Wien. florian.zeugswetter@vetmeduni.ac.at
authors.forename: F
authors.initials: F
authors.lastname: Zeugswetter
authors.forename: M
authors.initials: M
authors.lastname: Pagitz
authors.forename: K
authors.initials: K
authors.lastname: Hittmair
authors.forename: I
authors.initials: I
authors.lastname: Schwendenwein
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis*; D004285:Dogs; D005260:Female; D008163:Luminescent Measurements / Q000592:standards / Q000662:veterinary*; D008297:Male; D047748:Pituitary ACTH Hypersecretion / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D000324:Adrenocorticotropic Hormone