title: Orthopaedic gene therapy using recombinant adeno-associated virus vectors.
abstract: Use of recombinant adeno-associated virus (rAAV) vectors is increasingly gaining popularity in gene therapy because of their desirable properties, including lack of pathogenicity, efficient transduction of dividing and non-dividing cells, and sustained maintenance of the viral genome. It is these features of rAAV vectors that made them the focus for gene-based therapy of skeletal tissue regeneration. This review outlines the biological characteristics of adeno-associated virus (AAV), states the biological processing as well as current advances of rAAV vectors, and describes the recent achievements of their applications in orthopaedic and craniofacial surgery.
authors.affiliation: Discipline of Oral & Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong, China.
authors.forename: J
authors.initials: J
authors.lastname: Ke
authors.forename: L W
authors.initials: LW
authors.lastname: Zheng
authors.forename: L K
authors.initials: LK
authors.lastname: Cheung
mesh_terms: D001847:Bone Diseases / Q000628:therapy*; D001861:Bone Regeneration / Q000235:genetics; D000229:Dependovirus / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics / Q000627:therapeutic use*; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D019637:Orthopedic Procedures; D010957:Plasmids / Q000235:genetics / Q000627:therapeutic use; D014161:Transduction, Genetic / Q000379:methods