title: Initial structural studies of charged receptors that bind to inorganic phosphate anion and to an anionic phospholipid found in bacterial membranes.
abstract: ITC titration studies of a family of bis-ammonium receptors based upon a scaffold of two bis-linked phenol rings show that several of the receptors bind to both dihydrogenphosphate and phosphatidylglycerol anions in a similar binding motif. Thermodynamic properties determined from ITC show that anion binding is entropy driven. Job plots determined from (1)H NMR clearly demonstrate that anion-receptor binding stoichiometry is dependent on the receptor's length of its bis-amine linkage.
authors.affiliation: Department of Chemistry, Wichita State University, Wichita, Kansas 67260, USA.
authors.forename: Manjula B
authors.initials: MB
authors.lastname: Koralegedara
authors.forename: Hong W
authors.initials: HW
authors.lastname: Aw
authors.forename: Dennis H
authors.initials: DH
authors.lastname: Burns
mesh_terms: D001419:Bacteria / Q000166:cytology*; D002462:Cell Membrane / Q000737:chemistry*; D019277:Entropy; D010710:Phosphates / Q000737:chemistry*; D010715:Phosphatidylglycerols / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000378:metabolism
chemical_list: D010710:Phosphates; D010715:Phosphatidylglycerols; D010743:Phospholipids; D000644:Quaternary Ammonium Compounds