title: HIV testing strategies: test performance is important, but not sufficient.
abstract: Minimum accuracy of HIV diagnostic tests is considered the pillar on which testing strategies for all settings must be based. Systematic reviews and meta-analyses have shown that performance of the same test in different settings may vary according to several factors, resulting in different confidence intervals for sensitivity and specificity. Prevalence of HIV infection may influence observed test accuracy. The purpose of this article is to use the knowledge from meta-analyses of general diagnostic tests to inform the specific field of HIV diagnostic strategies. We propose the 'Bayesian' thinking: considering the pretest probability (i.e., prevalence, risk factors) and understanding test limitations to estimate a post-test probability of HIV diagnosis. Cost-effectiveness analysis, patient preferences and ethical issues must also be considered in HIV testing strategies.
authors.affiliation: Hospital das Clínicas, Federal University of Minas Gerais, Brazil.
authors.forename: Gláucia Fernandes
authors.initials: GF
authors.lastname: Cota
authors.forename: Teresa Cristina
authors.initials: TC
authors.lastname: de Abreu Ferrari
authors.forename: Marcos Roberto
authors.initials: MR
authors.lastname: de Sousa
mesh_terms: D015492:AIDS Serodiagnosis / Q000191:economics / Q000379:methods* / Q000592:standards*; D000465:Algorithms; D001499:Bayes Theorem; D003362:Cost-Benefit Analysis; D015658:HIV Infections / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D012680:Sensitivity and Specificity