title: In vitro antimicrobial activity of razupenem (SMP-601, PTZ601) against anaerobic bacteria.
abstract: We evaluated the in vitro antianaerobic activity of razupenem (SMP-601, PTZ601), a new parenterally administered carbapenem, against 70 reference strains and 323 clinical isolates. Razupenem exhibited broad-spectrum activity against anaerobes, inhibiting most of the reference strains when used at a concentration of ≤1 μg/ml. Furthermore, it exhibited strong activity, comparable to those of other carbapenems (meropenem and doripenem), against clinically isolated non-fragilis Bacteroides spp. (MIC90s of 2 μg/ml), with MIC90 values of 0.06, 0.03, and 0.5 μg/ml against Prevotella spp., Porphyromonas spp., and Fusobacterium spp., respectively. Clinical isolates of anaerobic Gram-positive cocci, Eggerthella spp., and Clostridium spp. were highly susceptible to razupenem (MIC90s, 0.03 to 1 μg/ml).
authors.affiliation: United Graduate School of Drug Discovery and Medical Information Sciences, Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
authors.forename: Chau Minh
authors.initials: CM
authors.lastname: Tran
authors.forename: Kaori
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Goto
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Mikamo
authors.forename: Kunitomo
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D001421:Bacteria, Anaerobic / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D005673:Fusobacterium / Q000187:drug effects; D006089:Gram-Negative Anaerobic Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D017861:Porphyromonas / Q000187:drug effects; D018720:Prevotella / Q000187:drug effects
chemical_list: D015780:Carbapenems