title: Mice do not develop conditioned taste aversion because of immunity loss.
abstract: OBJECTIVE
  This study intends to test the generation of conditioned taste aversion and conditioned immunodepression by daily paired administration of saccharin solution with cyclophosphamide, 15 mg/kg, for 4 days.
  
  
  METHODS
  One group of male mice of the outbred CD1 strain drank 0.15% saccharin and received 1 injection of cyclophosphamide, 15 mg/kg, for 4 days (paired group), another group (unpaired group) received the same doses of saccharin and cyclophosphamide noncontingently, the third group (cy60) received saccharin paired with cyclophosphamide, 60 mg/kg, and the fourth group (placebo) received saccharin in the absence of cyclophosphamide. All mice were immunized with keyhole limpet hemocyanin (KLH), 0.2 mg, 1 day before the treatments.
  
  
  RESULTS
  Mice of the paired, unpaired and cy60 groups displayed a similarly decreased antibody response to KLH, but mice of the paired group did not develop an aversion to saccharin while mice of the cy60 group did. Besides, repeat presentation of saccharin to mice of the paired group did not alter their antibody response to ovalbumin compared with mice of the unpaired or placebo group.
  
  
  CONCLUSIONS
  Taste aversion was not elicited in response to impaired immunity and the conditioned stimulus (saccharin) did not impair the antibody response.
authors.affiliation: Department of Personality, University of Barcelona School of Psychology, Barcelona, Spain. jvidal@ub.edu
authors.forename: Jose
authors.initials: J
authors.lastname: Vidal
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology*; D007108:Immune Tolerance / Q000502:physiology; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D051379:Mice; D013649:Taste / Q000276:immunology*; D013651:Taste Disorders / Q000276:immunology* / Q000523:psychology
chemical_list: D007166:Immunosuppressive Agents