title: The primary cilium: A relevant characteristic in interstitial cells of rat duodenum enteric plexus.
abstract: Studies in vitro have permitted the identification of enteric neural progenitor cells. Now the question arises as to where these progenitor cells are located in vivo. The purpose of this paper is to identify possible candidate cells by means of transmission electron microscopy (TEM). We have located three interstitial cellular types around the rat duodenum myenteric plexus. Type I cells have been identified as Interstitial Cells of Cajal (ICCs). These cells present well defined ultrastructural characteristics, including the triple connexion IC- nervous trunk- blood vessels. Type II cells show characteristics of immature cells, emphasizing the presence of a single cilium with the structure (9+0). To analyse this nanostructure, we have elaborated a reconstruction on ultrathin sections. The two previously described cellular types could be considered to be different functional states of the same cell. Type III cells present ultrastructural characteristics of fibroblast-like cells. This study suggests that Type II cells could be a source of neural progenitor cells.
authors.affiliation: Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain. cjunquer@unizar.es
authors.forename: Concepción
authors.initials: C
authors.lastname: Junquera Escribano
authors.forename: Irene
authors.initials: I
authors.lastname: Cantarero Carmona
authors.forename: María José
authors.initials: MJ
authors.lastname: Luesma Bartolomé
authors.forename: Mario
authors.initials: M
authors.lastname: Soriano-Navarro
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez-Ciriano
authors.forename: Tomás
authors.initials: T
authors.lastname: Castiella Muruzábal
authors.forename: José-Manuel
authors.initials: JM
authors.lastname: García-Verdugo
mesh_terms: D000818:Animals; D002923:Cilia / Q000648:ultrastructure*; D004386:Duodenum / Q000294:innervation*; D005347:Fibroblasts / Q000648:ultrastructure; D005724:Ganglia / Q000648:ultrastructure; D056885:Interstitial Cells of Cajal / Q000648:ultrastructure*; D046529:Microscopy, Electron, Transmission; D009197:Myenteric Plexus / Q000166:cytology*; D032389:Myocytes, Smooth Muscle / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D013234:Stem Cells / Q000648:ultrastructure