title: Electrospinning of chitosan derivative nanofibers with structural stability in an aqueous environment.
abstract: We report a simple method to produce stable chitosan derivative nanofibers via electrospinning. A chitosan solution with lactate salt was electrospun to produce nanofibers, followed by thermal treatment to enhance fiber stability. Chemical and morphological analyses demonstrated that the resulting nanofibers were crosslinked via amidation between chitosan and lactate salt. These fibers exhibited sustained morphological and structural stabilities to serve as a scaffold for biomedical applications.
authors.affiliation: Department of Materials Science and Engineering, University of Washington, 302L Roberts Hall, Seattle, WA 98195, USA.
authors.forename: Ashleigh
authors.initials: A
authors.lastname: Cooper
authors.forename: Narayan
authors.initials: N
authors.lastname: Bhattarai
authors.forename: Forrest M
authors.initials: FM
authors.lastname: Kievit
authors.forename: Michael
authors.initials: M
authors.lastname: Rossol
authors.forename: Miqin
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002460:Cell Line; D049109:Cell Proliferation; D002470:Cell Survival; D048271:Chitosan / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry / Q000378:metabolism; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000191:economics / Q000379:methods*; D012583:Schwann Cells / Q000166:cytology; D054457:Tissue Scaffolds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D014867:Water; D019344:Lactic Acid; D048271:Chitosan