title: Glyceollin, a soybean phytoalexin with medicinal properties.
abstract: This review covers the biosynthesis of glyceollin and its biological activities including antiproliferative/antitumor action (toward B16 melanoma cells, LNCaP prostate cancer cells, and BG-1 ovarian cancer cells), anti-estrogenic action (through estrogen receptors α- and β-), antibacterial action (toward Erwinia carotovora, Escherichia coli, Bradyrhizobium japonicum, Sinorhizobium fredii ), antinematode activity, and antifungal activity (toward Fusarium solani, Phakospora pachyrhizi, Diaporthe phaseolorum, Macrophomina phaseolina, Sclerotina sclerotiorum, Phytophthora sojae, Cercospora sojina, Phialophora gregata, and Rhizoctonia solani). Other activities include insulinotropic action and attenuation of vascular contractions in rat aorta.
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories Hong Kong, China. b021770@mailserv.cuhk.edu.hk
authors.forename: Tzi Bun
authors.initials: TB
authors.lastname: Ng
authors.forename: Xiu Juan
authors.initials: XJ
authors.lastname: Ye
authors.forename: Jack Ho
authors.initials: JH
authors.lastname: Wong
authors.forename: Evandro Fei
authors.initials: EF
authors.lastname: Fang
authors.forename: Yau Sang
authors.initials: YS
authors.lastname: Chan
authors.forename: Wenliang
authors.initials: W
authors.lastname: Pan
authors.forename: Xiu Yun
authors.initials: XY
authors.lastname: Ye
authors.forename: Stephen Cho Wing
authors.initials: SC
authors.lastname: Sze
authors.forename: Kalin Yanbo
authors.initials: KY
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: He Xiang
authors.initials: HX
authors.lastname: Wang
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D004358:Drug Therapy; D006801:Humans; D036343:Pterocarpans / Q000096:biosynthesis / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000378:metabolism / Q000494:pharmacology*; D013025:Glycine max / Q000737:chemistry* / Q000378:metabolism; D000094162:Phytoalexins
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D036343:Pterocarpans; D012717:Sesquiterpenes; C017343:glyceollin; D000094162:Phytoalexins