title: Could intra-alveolar hemosiderin deposition in adults be used as a marker for previous asphyxial episodes in cases of autoerotic death?
abstract: Intra-alveolar hemorrhage and hemosiderin have been cited as possible markers of recent and remote asphyxial events. Little study has been undertaken of the potential significance of intra-alveolar hemosiderin in adults as a potential marker of previous sublethal asphyxial episodes. Ten cases of lethal sexual asphyxia (an entity known to be associated with repetitive sublethal asphyxial episodes) and 20 randomly selected, age- and sex-matched controls had sections of lung stained for hemosiderin. Subsequently, intra-alveolar, iron-containing macrophages were counted. All cases were men (ages 15-50 years; mean 31.8). No significant increase in hemosiderin was found in victims of sexual asphyxia, indicating that asphyxial episodes in sublethal sexual asphyxial activities may not be sufficiently intense or prolonged to cause intra-alveolar hemorrhage or that intra-alveolar hemorrhage in adults is a relatively nonspecific finding. These results do not support intra-alveolar hemosiderin deposition as a marker for previous sublethal asphyxial events in autoerotic asphyxia.
authors.affiliation: Discipline of Pathology, Level 3 Medical School North Building, The University of Adelaide and Forensic Science SA, Adelaide 5005, SA, Australia. roger.byard@sa.gov.au
authors.forename: Roger W
authors.initials: RW
authors.lastname: Byard
authors.forename: Homeyra
authors.initials: H
authors.lastname: Masoumi
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Haas
authors.forename: Martin
authors.initials: M
authors.lastname: Sage
authors.forename: Henry F
authors.initials: HF
authors.lastname: Krous
mesh_terms: D000293:Adolescent; D000328:Adult; D001237:Asphyxia / Q000175:diagnosis*; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D049429:Forensic Pathology; D006470:Hemorrhage / Q000378:metabolism / Q000473:pathology; D006485:Hemosiderin / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010262:Paraphilic Disorders; D011650:Pulmonary Alveoli / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006485:Hemosiderin