title: Lifestyle intervention in men with advanced prostate cancer receiving androgen suppression therapy: a feasibility study.
abstract: BACKGROUND
  Healthy lifestyle behaviors could have a role in ameliorating some of the adverse effects of androgen suppression therapy (AST) in men with prostate cancer. The primary aim of this study was to assess the feasibility of a tapered supervised exercise program in combination with dietary advice in men with advanced prostate cancer receiving AST.
  
  
  METHODS
  Advanced prostate cancer patients receiving AST for a minimum of 6 months were randomized to a 12-week lifestyle program comprising aerobic and resistance exercise, plus dietary advice (n = 25), or standard care (n = 25). Exercise behavior, dietary macronutrient intake, quality of life, fatigue, functional fitness, and biomarkers associated with disease progression were assessed at baseline, after the intervention, and at 6 months.
  
  
  RESULTS
  The lifestyle group showed improvements in exercise behavior (P < 0.001), dietary fat intake (P = 0.001), total energy intake (P = 0.005), fatigue (P = 0.002), aerobic exercise tolerance (P < 0.001), and muscle strength (P = 0.033) compared with standard care controls. Although a high rate of attrition (44%) was observed at 6 months, the improvements in key health outcomes were sustained. No effects on clinical prostate cancer disease markers were observed.
  
  
  CONCLUSIONS
  This preliminary evidence suggests that pragmatic lifestyle interventions have potential to evoke improvements in exercise and dietary behavior, in addition to other important health outcomes in men with advanced prostate cancer receiving AST.
  
  
  CONCLUSIONS
  This study shows for the first time that pragmatic lifestyle interventions are feasible and could have a positive impact on health behaviors and other key outcomes in men with advanced prostate cancer receiving AST.
authors.affiliation: Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, United Kingdom.
authors.forename: Liam
authors.initials: L
authors.lastname: Bourke
authors.forename: Helen
authors.initials: H
authors.lastname: Doll
authors.forename: Helen
authors.initials: H
authors.lastname: Crank
authors.forename: Amanda
authors.initials: A
authors.lastname: Daley
authors.forename: Derek
authors.initials: D
authors.lastname: Rosario
authors.forename: John M
authors.initials: JM
authors.lastname: Saxton
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D004032:Diet; D015444:Exercise; D005240:Feasibility Studies; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists