title: Effect of subzero-balanced ultrafiltration on lung gas exchange capacity after cardiopulmonary bypass in adult patients with heart valve disease.
abstract: OBJECTIVE
  This study was conducted to evaluate the effect of a new ultrafiltration technique--the subzero-balanced ultrafiltration (SBUF)--on lung gas exchange capacity after cardiopulmonary bypass (CPB) in adult patients with heart valve disease.
  
  
  BACKGROUND
  Attenuation of lung gas exchange capacity is one of the most common manifestations of an inflammatory response after CPB.
  
  
  METHODS
  Ninety-four patients who required CPB for cardiac surgery were randomized into 2 groups according to whether they received SBUF. Gas exchange capacity expressed as the oxygen index (OI), the respiratory index (RI), and the alveolar-arterial oxygen pressure difference (P(A-a)O2) were measured after intubation (T1), at the termination of CPB (T2), on admission to the intensive care unit (ICU) (T3), at postoperative hour 6 (T4), and at postoperative hour 12 (T5).
  
  
  RESULTS
  There were no significant differences in gas exchange capacity between the 2 groups at T1, T4, and T5. CPB produced significant changes in OI, RI, and P(A-a)O2 in the control group, whereas these changes were not significantly different in the study group. The OI in the study group was significantly higher at T2, and RI and P(A-a)O2 were significantly lower at T2 and T3. In the study group, the intubation time was shorter, and the transfusion volume within 24 hours postoperatively was less. The 2 groups were comparable with respect to the incidence of respiratory complications, length of stay in the ICU, duration of hospital stay, need for infusions of inotropic agents, and drainage volumes within 24 hours postoperatively.
  
  
  CONCLUSIONS
  SBUF during CPB can produce an immediate improvement in lung gas exchange capacity, which may effectively minimize pulmonary dysfunction in adult patients undergoing cardiac surgery.
authors.affiliation: Department of Cardiovascular Surgery, Chinese PLA General Hospital, FuXing Road #28, Beijing, China. zhtony301@hotmail.com
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Sheng-li
authors.initials: SL
authors.lastname: Jiang
authors.forename: Chang-qing
authors.initials: CQ
authors.lastname: Gao
authors.forename: Jin
authors.initials: J
authors.lastname: Luo
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.forename: Jia-chun
authors.initials: JC
authors.lastname: Li
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D006349:Heart Valve Diseases / Q000150:complications / Q000601:surgery*; D006801:Humans; D055370:Lung Injury / Q000209:etiology* / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011659:Pulmonary Gas Exchange; D016896:Treatment Outcome; D014462:Ultrafiltration / Q000379:methods*