title: Unusual inversion phenomenon of β-cyclodextrin dimers in water.
abstract: A conformational analysis of three triazole-containing bridged bis-β- cyclodextrins (CD) has been carried out to evaluate their recognition ability. NMR spectroscopy and ITC measurements clearly demonstrate that one of the CD glucopyranose units undergoes a 360° rotation in water so that the spacer linking the two CDs is deeply included into one of the CD cavities. The amplitude of this inversion phenomenon depends on the nature of the spacer and results in a limited accessibility to the CD cavities in line with previous catalytic results.
authors.affiliation: Université Lille Nord de France, CNRS UMR 8181, Unité de Catalyse et de Chimie du Solide, UCCS UArtois, Faculté Jean Perrin, Lens, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Menuel
authors.forename: Nathalie
authors.initials: N
authors.lastname: Azaroual
authors.forename: David
authors.initials: D
authors.lastname: Landy
authors.forename: Natacha
authors.initials: N
authors.lastname: Six
authors.forename: Frédéric
authors.initials: F
authors.lastname: Hapiot
authors.forename: Eric
authors.initials: E
authors.lastname: Monflier
mesh_terms: D002151:Calorimetry; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D014230:Triazoles / Q000737:chemistry*; D014867:Water / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D014230:Triazoles; D047392:beta-Cyclodextrins; D014867:Water