title: A new erythrodiol triterpene fatty ester from Scorzonera mongolica.
abstract: Two erythrodiol triterpene fatty esters, 3beta-dodecanoyl erythrodiol (1) and 3beta-tetradecanoyl erythrodiol (2), were isolated from Scorzonera mongolica. Their structures were elucidated on the basis of IR, MS and extensive 2D NMR spectroscopic analysis. Compound 1 was identified to be a new compound and 2 was confirmed to be a new natural compound. Their antitumor effects in vitro were evaluated with MTT and SRB assays, but compounds 1 and 2 only showed moderate cytotoxicities on A-549 cell line.
authors.affiliation: School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316000, China. binwang4159@hotmail.com
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Guo-qiang
authors.initials: GQ
authors.lastname: Li
authors.forename: Hua-shi
authors.initials: HS
authors.lastname: Guan
authors.forename: Li-ye
authors.initials: LY
authors.lastname: Yang
authors.forename: Guo-zhong
authors.initials: GZ
authors.lastname: Tong
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D045744:Cell Line, Tumor / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D031186:Scorzonera / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C583053:3beta-dodecanoyl erythrodiol; C583054:3beta-tetradecanoyl erythrodiol; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes