title: Synthesis of an acromelic acid A analog-based 11C-labeled PET tracer for exploration of the site of action of acromelic acid A in allodynia induction.
abstract: A novel (11)C-labeled PET (positron emission tomography) tracer, which was designed based on the (phenylthio)pyrrolidine derivative that can competitively block the acromelic acid A-induced allodynia, was synthesized. A protocol in which methylation by palladium-mediated coupling of the boronate derivative with [(11)C]CH(3)I and deprotection of the protected amino acid moiety are successively performed in one-pot within 5 min was established for the synthesis of the tracer. The tracer is potentially useful as a tool to investigate the mode of action of acromelic acid A in the induction of allodynia.
authors.affiliation: Field of Biological Molecular Sciences, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Kanazawa
authors.forename: Kyoji
authors.initials: K
authors.lastname: Furuta
authors.forename: Hisashi
authors.initials: H
authors.lastname: Doi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Mori
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Minami
authors.forename: Seiji
authors.initials: S
authors.lastname: Ito
authors.forename: Masaaki
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D006930:Hyperalgesia / Q000139:chemically induced*; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008745:Methylation; D051379:Mice; D049268:Positron-Emission Tomography
chemical_list: C051743:acromelic acid A; D007608:Kainic Acid