title: p53 guards the metabolic pathway less travelled.
abstract: Glucose is an important source of energy and carbon, and is required for cell growth. As such, glucose utilization is increased in rapidly dividing cancer cells. The tumour suppressor p53 has now been reported to block a metabolic pathway (the pentose phosphate pathway) that diverts glucose away from bioenergetic into biosynthetic routes.
authors.forename: Eyal
authors.initials: E
authors.lastname: Gottlieb
mesh_terms: D000483:Alleles; D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010427:Pentose Phosphate Pathway; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53; D005947:Glucose; D010100:Oxygen