title: Sleep deprivation increases blood pressure in healthy normotensive elderly and attenuates the blood pressure response to orthostatic challenge.
abstract: OBJECTIVE
  To determine how aging affects the impact of sleep deprivation on blood pressure at rest and under orthostatic challenge.
  
  
  METHODS
  Subjects underwent a night of sleep and 24.5 h of sleep deprivation in a crossover counterbalanced design.
  
  
  METHODS
  Sleep laboratory.
  
  
  METHODS
  Sixteen healthy normotensive men and women: 8 young adults (mean 24 years [SD 3.1], range 20-28 years) and 8 elderly adults (mean 64.1 years [SD 3.4], range 60-69 years).
  
  
  METHODS
  Sleep deprivation.
  
  
  RESULTS
  Brachial cuff arterial blood pressure and heart rate were measured in semi-recumbent and upright positions. These measurements were compared across homeostatic sleep pressure conditions and age groups. Sleep deprivation induced a significant increase in systolic and diastolic blood pressure in elderly but not young adults. Moreover, sleep deprivation attenuated the systolic blood pressure orthostatic response in both age groups.
  
  
  CONCLUSIONS
  Our results suggest that sleep deprivation alters the regulatory mechanisms of blood pressure and might increase the risk of hypertension in healthy normotensive elderly.
authors.affiliation: Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada.
authors.forename: Rébecca
authors.initials: R
authors.lastname: Robillard
authors.forename: Paola A
authors.initials: PA
authors.lastname: Lanfranchi
authors.forename: François
authors.initials: F
authors.lastname: Prince
authors.forename: Daniel
authors.initials: D
authors.lastname: Filipini
authors.forename: Julie
authors.initials: J
authors.lastname: Carrier
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012890:Sleep / Q000502:physiology; D012892:Sleep Deprivation / Q000150:complications / Q000503:physiopathology*; D055815:Young Adult