title: Interleaved variable density sampling with a constrained parallel imaging reconstruction for dynamic contrast-enhanced MR angiography.
abstract: For MR applications such as contrast-enhanced MR angiography, it is desirable to achieve simultaneously high spatial and temporal resolution. The current clinical standard uses view-sharing methods combined with parallel imaging; however, this approach still provides limited spatial and temporal resolution. To improve on the clinical standard, we present an interleaved variable density (IVD) sampling method that pseudorandomly undersamples each individual frame of a 3D Cartesian ky-kz plane combined with parallel imaging acceleration. From this dataset, time-resolved images are reconstructed with a method that combines parallel imaging with a multiplicative constraint. Total acceleration factors on the order of 20 are achieved for contrast-enhanced MR angiography of the lower extremities, and improvements in temporal fidelity of the depiction of the contrast bolus passage are demonstrated relative to the clinical standard.
authors.affiliation: Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705-2275, USA.
authors.forename: Kang
authors.initials: K
authors.lastname: Wang
authors.forename: Reed F
authors.initials: RF
authors.lastname: Busse
authors.forename: James H
authors.initials: JH
authors.lastname: Holmes
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Beatty
authors.forename: Jean H
authors.initials: JH
authors.lastname: Brittain
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Francois
authors.forename: Scott B
authors.initials: SB
authors.lastname: Reeder
authors.forename: Jiang
authors.initials: J
authors.lastname: Du
authors.forename: Frank R
authors.initials: FR
authors.lastname: Korosec
mesh_terms: D000465:Algorithms; D001158:Arteries / Q000033:anatomy & histology*; D003287:Contrast Media; D003627:Data Interpretation, Statistical; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D015203:Reproducibility of Results; D018401:Sample Size; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media