title: Clinically accurate orthotopic mouse models of cancer.
abstract: In the past 10 years, we have developed a new approach to the development of a clinically accurate rodent model for human cancer based on our invention of surgical orthotopic implantation (SOI). The SOI models have been described in approx 70 publications (2-72) and in four patents.* SOI allows human tumors of all the major types of human cancer to reproduce clinical-like tumor growth and metastasis in the transplanted rodents (2-72). The major features of the SOI models are reviewed here and also compared to transgenic mouse models of cancer.
authors.affiliation: AntiCancer, Inc. and Department of Surgery, University of California, San Diego, CA.
authors.forename: R M
authors.initials: RM
authors.lastname: Hoffman