title: Bronchial hyper-reactivity in migraine without aura: is it a new clue for inflammation?
abstract: OBJECTIVE
  We attempted to investigate the relationship between migraine without aura (MwoA) and bronchial hyper-reactivity to postulate inflammation as an underlying mechanism in migraine.
  
  
  BACKGROUND
  Comorbidity of migraine and atopic diseases such as asthma has been an argument for suspected immune system dysfunction in migraineurs.
  
  
  METHODS
  Twenty patients with MwoA and 5 control subjects without history of atophy and asthma were included in study. Subjects with abnormal physical examination and chest radiographs were excluded. After a normal spirometry, methacholine bronchoprovocation test was performed in all subjects and controls according to 5 breath dosimeter methods.
  
  
  RESULTS
  Sixteen of 20 patients and 2 of 5 control subjects were women. Mean ages were 37.5 (19-56) and 33.8 (26-43) years, respectively. Methacholine bronchoprovocation test was positive in 3 patients (15%) but was normal in all controls (0%).
  
  
  CONCLUSIONS
  The relationship between MwoA and bronchial hyper-reactivity may help to postulate the inflammation in migraine as an underlying mechanism.
authors.affiliation: From the Departments of Neurology, Mersin University School of Medicine, Mersin, Turkey (H. Kaleagasi and A. Özge); the Departments of Chest Diseases, Mersin University School of Medicine, Mersin, Turkey (E. Özgür and C. Özge).
authors.forename: Hakan
authors.initials: H
authors.lastname: Kaleagasi
authors.affiliation: From the Departments of Neurology, Mersin University School of Medicine, Mersin, Turkey (H. Kaleagasi and A. Özge); the Departments of Chest Diseases, Mersin University School of Medicine, Mersin, Turkey (E. Özgür and C. Özge).
authors.forename: Eylem
authors.initials: E
authors.lastname: Özgür
authors.affiliation: From the Departments of Neurology, Mersin University School of Medicine, Mersin, Turkey (H. Kaleagasi and A. Özge); the Departments of Chest Diseases, Mersin University School of Medicine, Mersin, Turkey (E. Özgür and C. Özge).
authors.forename: Cengiz
authors.initials: C
authors.lastname: Özge
authors.affiliation: From the Departments of Neurology, Mersin University School of Medicine, Mersin, Turkey (H. Kaleagasi and A. Özge); the Departments of Chest Diseases, Mersin University School of Medicine, Mersin, Turkey (E. Özgür and C. Özge).
authors.forename: Aynur
authors.initials: A
authors.lastname: Özge
mesh_terms: D000328:Adult; D016535:Bronchial Hyperreactivity / Q000453:epidemiology / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020326:Migraine without Aura / Q000453:epidemiology / Q000503:physiopathology*; D010865:Pilot Projects; D012129:Respiratory Function Tests