title: Breast cancer stem cells: a new target for therapy.
abstract: Normal adult tissue stem cells awake from a dormant state to grow, differentiate, and regenerate damaged tissue. They also travel in the circulation and colonize distant organs at sites undergoing tissue repair. These same traits are utilized or co-opted by metastatic cancer cells. The cancer stem cell theory proposes that tumors emerge from a subpopulation of cancer cells that possess stem cell properties. This theory has profound implications for therapy. A small number of cancer stem cells may lie dormant following conventional therapy and tumor remission, only to re-emerge and regenerate the entire recurrent cancer. Consequently, it has been proposed that targeting cancer stem cells is the only way to obtain durable cancer treatment responses. Several strategies for targeting cancer stem cells have been proposed. Nevertheless, a number of issues must be investigated and resolved before effective treatments targeting cancer stem cells can enter clinical testing.
authors.affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Federici
authors.forename: Virginia
authors.initials: V
authors.lastname: Espina
authors.forename: Lance
authors.initials: L
authors.lastname: Liotta
authors.forename: Kirsten H
authors.initials: KH
authors.lastname: Edmiston
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D051927:CD24 Antigen / Q000032:analysis; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000473:pathology
chemical_list: D051927:CD24 Antigen; D018960:Hyaluronan Receptors