title: Predictors of 12-week remission in a nationwide cohort of  people with depressive disorders: the CRESCEND study.
abstract: OBJECTIVE
  To estimate the 12-week remission rate of patients with depressive disorders and predictors of this in a naturalistic clinical setting in South Korea.
  
  
  METHODS
  For people with DSM-IV depressive disorders about to receive treatment at 18 hospitals, data on sociodemographic and health status were obtained. A free choice of clinical interventions was allowed and naturalistic follow-up took place at 1, 2, 4, 8, and 12 weeks later. Remission was defined as a Hamilton Depression Rating Scale score of ≤7 sustained to 12 weeks or last follow-up, if earlier.
  
  
  RESULTS
  For 723 participants, the 12-week remission rate was 31.4%. Remission was more likely in women, and in patients without a prior history of suicide attempt, and those with lower baseline anxiety.
  
  
  CONCLUSIONS
  Remission associated with unrestricted clinical interventions was comparable to STAR*D estimates for citalopram alone. Comorbid anxiety and previous suicide attempt were markers of worse outcome.
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea. jmkim@chonnam.ac.kr
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Sung-Wan
authors.initials: SW
authors.lastname: Kim
authors.forename: Robert
authors.initials: R
authors.lastname: Stewart
authors.forename: Seon-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Jin-Sang
authors.initials: JS
authors.lastname: Yoon
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Jung
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Hyeon-Woo
authors.initials: HW
authors.lastname: Yim
authors.forename: Tae-Youn
authors.initials: TY
authors.lastname: Jun
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015283:Citalopram / Q000627:therapeutic use; D015331:Cohort Studies; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012074:Remission Induction / Q000379:methods; D056910:Republic of Korea; D012737:Sex Factors; D013406:Suicide, Attempted / Q000706:statistics & numerical data*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D015283:Citalopram