title: Evaluation of oxidative stress markers in first trimester for assessment of preeclampsia risk.
abstract: OBJECTIVE
  The aim of this study is to determine the predictive values of oxidative stress markers and antioxidants in the development of preeclampsia between 10-14 and also at 20-24 weeks of gestation, after the completion of vascular transformation.
  
  
  METHODS
  Levels of oxidative stress parameters such as malondialdehyde (MDA), lipidhydroperoxide (LHP) and prostaglandin F(2α) (PGF(2α)), oxidized LDL (oxLDL), and antioxidant status parameters such as paraoxonase 1 (PON1), superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels were measured and compared in 21 preeclamptic and 24 healthy pregnant women.
  
  
  RESULTS
  In preeclamptic women, both between 10-14 and also at 20-24 weeks of gestation the levels of oxLDL, MDA and PGF(2α) were significantly higher (P < 0.001, P < 0.001, respectively), PON1, SOD and TAC were significantly lower (P < 0.01, P < 0.001, P < 0.05, respectively) compared to healthy pregnant women; yet there was no significant difference in LHP levels.
  
  
  CONCLUSIONS
  Increased levels of serum MDA and PGF(2α), low levels of SOD and PON1 activity, in 10-14 GW may have been associated with preeclampsia etiology. High levels of MDA and PGF(2α) indicate that the oxidative damage is present well before the clinical symptoms occur. A panel of oxidative stress markers such as MDA and PGF(2α) in maternal blood can predict the development of preeclampsia long before clinical onset.
authors.affiliation: Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Cerrahpasa, 34303 Istanbul, Turkey.
authors.forename: Habibe
authors.initials: H
authors.lastname: Genc
authors.forename: Hafize
authors.initials: H
authors.lastname: Uzun
authors.forename: Ali
authors.initials: A
authors.lastname: Benian
authors.forename: Gönül
authors.initials: G
authors.lastname: Simsek
authors.forename: Remise
authors.initials: R
authors.lastname: Gelisgen
authors.forename: Rıza
authors.initials: R
authors.lastname: Madazli
authors.forename: Onur
authors.initials: O
authors.lastname: Güralp
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D015237:Dinoprost / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005865:Gestational Age; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood* / Q000201:enzymology / Q000453:epidemiology; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008315:Malondialdehyde; D015237:Dinoprost; D013482:Superoxide Dismutase; D043303:Aryldialkylphosphatase