title: Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa.
abstract: OBJECTIVE
  No studies have compared the response to selective serotonin reuptake inhibitors and atypical antipsychotics in anorexia nervosa. This case study examines such a comparison.
  
  
  METHODS
  This report describes a case of 12-year-old identical twins with anorexia nervosa, one of whom was treated with olanzapine and the other with fluoxetine, while undergoing family therapy.
  
  
  RESULTS
  Twin A treated with fluoxetine went from 75 to 84.4% ideal body weight, while Twin B treated with olanzapine went from 72 to 99.9% ideal body weight over the course of 9 months.
  
  
  CONCLUSIONS
  This case supports the need for adequately powered, controlled clinical trials to test the efficacy of olanzapine in adolescents presenting with anorexia nervosa.
authors.affiliation: Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Duvvuri
authors.forename: Taya
authors.initials: T
authors.lastname: Cromley
authors.forename: Megan
authors.initials: M
authors.lastname: Klabunde
authors.forename: Kerri
authors.initials: K
authors.lastname: Boutelle
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
mesh_terms: D000856:Anorexia Nervosa / Q000188:drug therapy* / Q000628:therapy; D001569:Benzodiazepines / Q000627:therapeutic use*; D002648:Child; D004200:Diseases in Twins / Q000188:drug therapy* / Q000628:therapy; D005196:Family Therapy; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D000077152:Olanzapine; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome; D014430:Twins, Monozygotic / Q000523:psychology; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D001569:Benzodiazepines; D005473:Fluoxetine; D000077152:Olanzapine; D017367:Selective Serotonin Reuptake Inhibitors