title: Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes.
abstract: Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.
authors.affiliation: Department Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK. S.G.Ward@bath.ac.uk
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Ward
authors.forename: John
authors.initials: J
authors.lastname: Westwick
authors.forename: Stephanie
authors.initials: S
authors.lastname: Harris
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D006801:Humans; D007422:Intestines / Q000166:cytology / Q000276:immunology; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D010711:Phosphatidate Phosphatase / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D020033:Protein Isoforms; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000201:enzymology* / Q000276:immunology*
chemical_list: D020033:Protein Isoforms; D019869:Phosphatidylinositol 3-Kinases; C112948:lipid phosphate phosphatase; D010744:Phosphoric Monoester Hydrolases; D010711:Phosphatidate Phosphatase; D051059:PTEN Phosphohydrolase