title: In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy.
abstract: Recently, the use of confocal laser endomicroscopy (CLE) in the diagnosis of chronic ulcerative colitis (CUC) was reported. In this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in CUC. The study involved a patient presenting long-standing CUC. Confocal imaging of both the inflamed mucosa, a circumscribed lesion (dysplasia-associated lesional mass), and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological images. Inflamed mucosa and dysplasia showed specific alteration of crypt architecture, cellular infiltration, and vessel architecture with an excellent correlation between CLE and standard histological examination.
authors.affiliation: Department of Surgery and Advanced Technologies, Center of Excellence for Technical Innovation in Surgery, Section of Diagnostic and Therapeutic Endoscopy, University of Naples Federico II, School of Medicine, 80131, Naples, Italy. giovanni.depalma@unina.it
authors.forename: Giovanni D
authors.initials: GD
authors.lastname: De Palma
authors.forename: Stefania
authors.initials: S
authors.lastname: Staibano
authors.forename: Saverio
authors.initials: S
authors.lastname: Siciliano
authors.forename: Francesco
authors.initials: F
authors.lastname: Maione
authors.forename: Maria
authors.initials: M
authors.lastname: Siano
authors.forename: Dario
authors.initials: D
authors.lastname: Esposito
authors.forename: Giovanni
authors.initials: G
authors.lastname: Persico
mesh_terms: D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000033:anatomy & histology* / Q000473:pathology*; D007834:Lasers; D018613:Microscopy, Confocal / Q000379:methods*; D008875:Middle Aged