title: Improvement of the dissolution rate of poorly soluble drugs by solid crystal suspensions.
abstract: We present a novel extrusion based approach where the dissolution rate of poorly soluble drugs (griseofulvin, phenytoin and spironolactone) is significantly accelerated. The drug and highly soluble mannitol are coprocessed in a hot melt extrusion operation. The obtained product is an intimate mixture of the crystalline drug and crystalline excipient, with up to 50% (w/w) drug load. The in vitro drug release from the obtained solid crystalline suspensions is over 2 orders of magnitude faster than that of the pure drug. Since the resulting product is crystalline, the accelerated dissolution rate does not bear the physical stability concerns inherent to amorphous formulations. This approach is useful in situations where the drug is not a good glass former or in cases where it is difficult to stabilize the amorphous drug. Being thermodynamically stable, the dissolution profile and the solid state properties of the product are maintained after storage at 40 °C, 75% RH for at least 90 days.
authors.affiliation: Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana, USA. markus.thommes@uni-duesseldorf.de
authors.forename: Markus
authors.initials: M
authors.lastname: Thommes
authors.forename: David R
authors.initials: DR
authors.lastname: Ely
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Carvajal
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Pinal
mesh_terms: D004355:Drug Stability; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D013535:Suspensions / Q000737:chemistry*; D013696:Temperature
chemical_list: D004364:Pharmaceutical Preparations; D013535:Suspensions