title: Association between ACE polymorphism and risk of IgA nephropathy: a meta-analysis.
abstract: BACKGROUND
  and objective: The effect of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism on risk or progression of immunoglobulin A nephropathy (IgAN) is still debated.Therefore, a meta-analysis was performed to evaluate the association of ACE gene polymorphism with IgAN in different ethnic groups.
  
  
  METHODS
  A predefined search strategy was performed to collect data from electronic databases.
  
  
  RESULTS
  Twenty articles were identified for the analysis of the relationship between ACE polymorphism and IgAN risk, including 11 in Asians and nine in Caucasians. There was a markedly positive association between the D allele or DD genotype and IgAN risk in Asians (OR = 1.27, p = 0.006; OR = 1.83, p < 0.0001). However, a link between D allele or DD genotype and IgAN risk was not found in Caucasians (OR = 1.04, p = 0.46; OR = 1.13, p = 0.12). Ten investigations were included for analysis of the association of ACE polymorphism with IgAN progression, including six in Asians and four in Caucasians. These data did not support a link between the ACE D allele or DD genotype and IgAN progression in Asians and Caucasians (Asians: D: OR = 1.03, p = 0.80; DD: OR = 1.43, p = 0.16; Caucasians: D: OR = 1.29, p = 0.22; DD: OR = 1.31, p = 0.17).
  
  
  CONCLUSIONS
  The D allele or DD genotype is associated with IgAN risk in Asian, but not in Caucasian populations; there was no significant association between the D allele or DD gene and IgAN progression for Asians and Caucasians.
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, China.
authors.forename: Yuan-Han
authors.initials: YH
authors.lastname: Qin
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Su
authors.forename: Feng-Ying
authors.initials: FY
authors.lastname: Lei
authors.forename: Wei-Fang
authors.initials: WF
authors.lastname: Huang
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Zhao
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000235:genetics*; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011507:Proteinuria / Q000150:complications / Q000235:genetics; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A