title: A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis.
abstract: A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC(50) values of 0.12 and 0.20 μg/mL, respectively.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Chung
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Tseng-Fu
authors.initials: TF
authors.lastname: Tseng
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Lei-Chin
authors.initials: LC
authors.lastname: Chen
authors.forename: Shou-Fang
authors.initials: SF
authors.lastname: Wu
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Lee
authors.forename: Zu-Yau
authors.initials: ZY
authors.lastname: Lin
authors.forename: Li-Yeh
authors.initials: LY
authors.lastname: Chuang
authors.forename: Jinu-Huang
authors.initials: JH
authors.lastname: Su
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D030022:Aristolochia / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004987:Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D019272:Leukocyte Elastase / Q000378:metabolism; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D001713:Biphenyl Compounds; D004987:Ethers; D011804:Quinolines; C492856:aristoquinoline A; D009240:N-Formylmethionine Leucyl-Phenylalanine; D019272:Leukocyte Elastase