title: Maternal and fetal exposure to pesticides associated to genetically modified foods in Eastern Townships of Quebec, Canada.
abstract: Pesticides associated to genetically modified foods (PAGMF), are engineered to tolerate herbicides such as glyphosate (GLYP) and gluphosinate (GLUF) or insecticides such as the bacterial toxin bacillus thuringiensis (Bt). The aim of this study was to evaluate the correlation between maternal and fetal exposure, and to determine exposure levels of GLYP and its metabolite aminomethyl phosphoric acid (AMPA), GLUF and its metabolite 3-methylphosphinicopropionic acid (3-MPPA) and Cry1Ab protein (a Bt toxin) in Eastern Townships of Quebec, Canada. Blood of thirty pregnant women (PW) and thirty-nine nonpregnant women (NPW) were studied. Serum GLYP and GLUF were detected in NPW and not detected in PW. Serum 3-MPPA and CryAb1 toxin were detected in PW, their fetuses and NPW. This is the first study to reveal the presence of circulating PAGMF in women with and without pregnancy, paving the way for a new field in reproductive toxicology including nutrition and utero-placental toxicities.
authors.affiliation: Department of Obstetrics and Gynecology, University of Sherbrooke Hospital Centre, Sherbrooke, Quebec, Canada. aziz.aris@usherbrooke.ca
authors.forename: Aziz
authors.initials: A
authors.lastname: Aris
authors.forename: Samuel
authors.initials: S
authors.lastname: Leblanc
mesh_terms: D000328:Adult; D000613:Aminobutyrates / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins / Q000097:blood; D001711:Biotransformation; D004731:Endotoxins / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D030841:Food, Genetically Modified; D008401:Gas Chromatography-Mass Spectrometry; D005998:Glycine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D006460:Hemolysin Proteins / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D009943:Organophosphorus Compounds / Q000097:blood; D010575:Pesticides / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D010756:Phosphoric Acids / Q000097:blood; D011247:Pregnancy; D011422:Propionates / Q000097:blood; D011792:Quebec; D000097797:Glyphosate
chemical_list: D000613:Aminobutyrates; D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins; D004731:Endotoxins; D005998:Glycine; D006460:Hemolysin Proteins; D009943:Organophosphorus Compounds; D010575:Pesticides; D010756:Phosphoric Acids; D011422:Propionates; D000097797:Glyphosate; C030956:insecticidal crystal protein, Bacillus Thuringiensis; C003121:phosphinothricin; C474431:methylphosphinicopropionic acid; C030242:phosphoric acid