title: Trends in incidence of childhood lymphoma in Khon Kaen, Thailand, 1985-2008.
abstract: BACKGROUND
  Lymphoma is the second most common of childhood cancer in Thailand, but data on trends over time are limited.
  
  
  OBJECTIVE
  To perform a statistic assessment of the incidence trend of childhood lymphoma in Khon Kaen, Thailand, between 1985 and 2008.
  
  
  METHODS
  All children aged < 15 years newly diagnosed with lymphoma according to International Childhood Cancer Classification (ICCC) during January 1, 1985- December 31, 2008 were collected from data base of Khon Kaen Provincial Registry. Aged-adjusted incidence rates (ASRs) were calculated by standard method and trends were calculated using the generalized linear model method <GLM>, which utilizes incidence-rate-base logarithms.
  
  
  RESULTS
  During 1985-2008 there were 72 children (47 boys and 25 girls) who were diagnosed with lymphoma in Khon Kaen province. The peak age-group of disease was in the 5-9 year olds for both sexes. All cases were pathologically proven. Non-Hodgkin lymphoma (NHL) was more common than Hodgkin disease (ratio 7:1). The overall ASR was 6.04 per million (95%CI: 4.64 to 7.45) and the ASR was 7.64 per million (95%CI: 5.44 to 9.84) in boys and 4.37 per million (95%CI: 2.64 to 6.10) in girls. Significant increases were observed for boys, since the 2006 to 2008 ASR was 15.3 per million (95%CI: 5.73 to 25.0). Trend analyses during 1985 - 2008 showed that incidence among boys for lymphoma increased by 1.38 percent per year (95%CI:- 4.6-8.3) while the incidence among girl decreased by 2.6 percent per year (95%CI:- 12-6.8).
  
  
  CONCLUSIONS
  Our data showed that the incidence of childhood lymphoma in Khon Kaen province was similar to the one of Thailand but lower than those of western countries. During the past 24 years, the incidence trend seems to be increasing in boys but decreasing in girls. Interpretation is difficult without a better understanding of what underlies the reported changes.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Khon Kaen University.
authors.forename: Aunjai
authors.initials: A
authors.lastname: Srina
authors.forename: Arunee
authors.initials: A
authors.lastname: Jetsrisuparb
authors.forename: Patcharee
authors.initials: P
authors.lastname: Komvilaisak
authors.forename: Supot
authors.initials: S
authors.lastname: Kamsaard
authors.forename: Surapon
authors.initials: S
authors.lastname: Wiangnon
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008223:Lymphoma / Q000453:epidemiology*; D008297:Male; D009026:Mortality / Q000639:trends*; D011379:Prognosis; D012042:Registries; D015996:Survival Rate; D013785:Thailand / Q000453:epidemiology; D013997:Time Factors