title: Adipose-derived stem cells in functional bone tissue engineering: lessons from bone mechanobiology.
abstract: This review aims to highlight the current and significant work in the use of adipose-derived stem cells (ASC) in functional bone tissue engineering framed through the bone mechanobiology perspective. Over a century of work on the principles of bone mechanosensitivity is now being applied to our understanding of bone development. We are just beginning to harness that potential using stem cells in bone tissue engineering. ASC are the primary focus of this review due to their abundance and relative ease of accessibility for autologous procedures. This article outlines the current knowledge base in bone mechanobiology to investigate how the knowledge from this area has been applied to the various stem cell-based approaches to engineering bone tissue constructs. Specific emphasis is placed on the use of human ASC for this application.
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695-7115, USA.
authors.forename: Josephine C
authors.initials: JC
authors.lastname: Bodle
authors.forename: Ariel D
authors.initials: AD
authors.lastname: Hanson
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Loboa
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000502:physiology* / Q000637:transplantation; D000818:Animals; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000639:trends*; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*; D023822:Tissue Engineering / Q000639:trends*