title: Cellular and subcellular localization of LETS protein in the nervous system.
abstract: In the nervous system of several mammalian and submammalian species, LETS protein is detectable on endothelial cells, choroid epithelial cells, fibroblasts and leptomeningeal cells. On endothelial cells LETS is present at the cell surface facing the blood vessel lumen, but not the glia limitans nor its basal lamina. Choroid epithelial cells do not carry LETS at their apices protruding into the ventricle, but are antigen-positive at their basal ends, in basal lamina and plasma membrane. Fibroblasts in the leptomeninges express LETS at their cell surface only, whereas pial and arachnoidal cells contain the protein also intracellularly. Neither glial nor neuronal cells express LETS protein. This pattern of LETS localization in nervous tissue was observed for adult and developing (embryonal day 9 onwards) animals of two species: mouse and chicken.
authors.affiliation: Department of Neuroscience, Children's Hospital Medical Center, Boston, Mass 02115, USA.
authors.forename: M
authors.initials: M
authors.lastname: Schachner
authors.forename: G
authors.initials: G
authors.lastname: Schoonmaker
authors.forename: R O
authors.initials: RO
authors.lastname: Hynes
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001001:Anura; D002645:Chickens; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D042783:Endothelial Cells / Q000378:metabolism* / Q000648:ultrastructure; D004847:Epithelial Cells / Q000378:metabolism* / Q000648:ultrastructure; D005347:Fibroblasts / Q000378:metabolism* / Q000648:ultrastructure; D005353:Fibronectins / Q000378:metabolism* / Q000648:ultrastructure; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D042541:Intracellular Space / Q000000981:diagnostic imaging / Q000378:metabolism*; D051379:Mice; D046529:Microscopy, Electron, Transmission / Q000379:methods; D009420:Nervous System / Q000166:cytology* / Q000196:embryology / Q000254:growth & development / Q000648:ultrastructure; D011817:Rabbits; D014426:Turtles; D014463:Ultrasonography
chemical_list: D005353:Fibronectins