title: [Expression changes of glutathione transferase omega 1 induced by low dose trichloroethylene].
abstract: OBJECTIVE
  To determine the expression of glutathione transferase omega 1 (GSTO-1) during hormesis induced by low dose trichloroethylene (TCE).
  
  
  METHODS
  Based on the dose-response of hormesis induced by TCE, the total protein and mRNA from four groups was extracted, and expression of GSTO-1 was detected by western blotting and RT-PCR technology.
  
  
  RESULTS
  The study showed that increases of GSTO-1 protein expression were induced by TCE at low dose (0.1 mmol/L) TCE, but there was no significant different between the high-dose group and the control (P < 0.05). RT-PCR analysis presented the expression of GSTO-1 gene in low-dose group was increased, but the opposite effect was observed in the high-dose group.
  
  
  CONCLUSIONS
  GSTO-1 may be play a key role in hormesis induced by TCE.
authors.affiliation: Toxicology Laboratory, Shenzhen Center for Disease Control and Prevention, Shenzhen 518020, China. hhy424@126.com
authors.forename: Haiyan
authors.initials: H
authors.lastname: Huang
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Zhuang
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Renrong
authors.initials: R
authors.lastname: Xi
authors.forename: Xiumei
authors.initials: X
authors.lastname: Xing
mesh_terms: D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism*; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D059165:Hormesis; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014241:Trichloroethylene / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D012333:RNA, Messenger; D014241:Trichloroethylene; C490476:GSTO1 protein, human; D005982:Glutathione Transferase