title: [Changes of redox processes in liver under pv-88 at experimental hemorrhagic shock].
abstract: PV-88 is the Ca2+ L channel blocker from pyrrole compounds, that has been used at hemorrhagic shock - HS (model of Shock was created by the method of (Wiggers-Feine) on 60th minute (intravenous administration, 3 mg/kg). Mean arterial pressure was 40 mmHg. Effects were studied on 80th minute after blood letting. Blood was exfused 40 ml/kg. Effect of PV-88 on redox processes in liver was studied. Experiments were carried out on male cats. Right lobe of the liver and the metabolic indices: ATP, CO, NAD, NADP, ALP, SDH, LDH were studied with the use of histochemistry (Pearse). Investigations have shown that on 80th minute after PV-88 administration CO (p<0.05), NADP (p<0.05), ALP (p<0.001), SDH (p<0.05), and LDH (p>0.05) were increased, while ATP (p<0.001) and NAD (p<0.001) were decreased. Increase in LDH was not statistically significant. According to the results of investigations, after administration of PV-88 at HS 60 on 80th minute, in liver increases oxygen concentration and aerobic process respectively.
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: Gr
authors.initials: G
authors.lastname: Sulaberidze
authors.forename: M
authors.initials: M
authors.lastname: Ghvaladze
authors.forename: G
authors.initials: G
authors.lastname: Didava
authors.forename: B
authors.initials: B
authors.lastname: Kochlamazashvili
authors.forename: M
authors.initials: M
authors.lastname: Chkhaidze
authors.forename: T
authors.initials: T
authors.lastname: Gegeshidze
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats; D003580:Cytochromes / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D023421:Models, Animal; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D012771:Shock, Hemorrhagic / Q000378:metabolism*; D013997:Time Factors
chemical_list: D002121:Calcium Channel Blockers; D003580:Cytochromes; D009243:NAD; D009249:NADP; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase; D010100:Oxygen