title: Reactive lymphoid hyperplasia of liver mimicking late ovarian cancer recurrence: case report and literature review.
abstract: Reactive lymphoid hyperplasia (RLH) is a rare, benign, lymphocytic tumour-like lesion reported in various organs. It has been previously identified in 18 cases in the English-language literature, but only 5 of them were related to oncological disease. No previous cases have been described of RLH occurring in ovarian cancer patients. We describe a case of hepatic RLH which developed in a patient treated for ovarian cancer 11 years previously. Radiological features on computed tomography (CT) scan and PET-CT (positron emission tomography-computed tomography) were strongly suggestive of oncological disease, in contrast to magnetic resonance imaging (MRI); the volume increment of the nodular lesion and the rise in carbohydrate antigen 125 corroborated the hypothesis of malignancy. The patient was subjected to resection of the 7th segment of the liver and the final histological report showed RLH. RLH should be considered in the presence of hepatic lesions in suspected ovarian cancer recurrence. Imaging techniques should be thoroughly investigated to exclude tumor recurrence promptly, in order to avoid unnecessary surgery.
authors.affiliation: Department of Obstetrics-Gynecology and Urology, Università di Roma La Sapienza, Viale del Policlinico 155, 00155 Rome, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Marchetti
authors.forename: Natalina
authors.initials: N
authors.lastname: Manci
authors.forename: Marco
authors.initials: M
authors.lastname: Di Maurizio
authors.forename: Chiara
authors.initials: C
authors.lastname: Di Tucci
authors.forename: Moira
authors.initials: M
authors.lastname: Burratti
authors.forename: Marialetizia
authors.initials: M
authors.lastname: Iuliano
authors.forename: Margherita
authors.initials: M
authors.lastname: Giorgini
authors.forename: Laura
authors.initials: L
authors.lastname: Salerno
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Benedetti Panici
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D049268:Positron-Emission Tomography; D019310:Pseudolymphoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D012008:Recurrence; D014057:Tomography, X-Ray Computed