title: LeEix1 functions as a decoy receptor to attenuate LeEix2 signaling.
abstract: The receptors for the fungal elicitor EIX (LeEix1 and LeEix2) belong to a class of leucine-rich repeat cell-surface glycoproteins with a signal for receptor-mediated endocytosis. Both receptors are able to bind the EIX elicitor while only the LeEix2 receptor mediates defense responses. We show that LeEix1 acts as a decoy receptor and attenuates EIX induced internalization and signaling of the LeEix2 receptor. We demonstrate that BAK1 binds LeEix1 but not LeEix2. In plants where BAK1 was silenced, LeEix1 was no longer able to attenuate plant responses to EIX, indicating that BAK1 is required for this attenuation. We suggest that LeEix1 functions as a decoy receptor for LeEix2, a function which requires the kinase activity of BAK1.
authors.affiliation: Tel Aviv University, Plant Sciences, Haim Levanon, Tel Aviv, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Bar
authors.forename: Miya
authors.initials: M
authors.lastname: Sharfman
authors.forename: Adi
authors.initials: A
authors.lastname: Avni
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D004705:Endocytosis / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D053319:Tumor Necrosis Factor Decoy Receptors / Q000235:genetics / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D010940:Plant Proteins; D053319:Tumor Necrosis Factor Decoy Receptors; C463660:BAK1 protein, Arabidopsis; D017346:Protein Serine-Threonine Kinases