title: Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence.
abstract: Tobacco smoking and nicotine exposure during adolescence interfere with prefrontal cortex (PFC) development and lead to cognitive impairments in later life. The molecular and cellular underpinnings of these consequences remain elusive. We found that adolescent nicotine exposure induced lasting attentional disturbances and reduced mGluR2 protein and function on presynaptic terminals of PFC glutamatergic synapses. Restoring mGluR2 activity in vivo by local infusion of a group II mGluR agonist in adult rats that received nicotine as adolescents rescued attentional disturbances.
authors.affiliation: Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam, The Netherlands.
authors.forename: Danielle S
authors.initials: DS
authors.lastname: Counotte
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Goriounova
authors.forename: Ka Wan
authors.initials: KW
authors.lastname: Li
authors.forename: Maarten
authors.initials: M
authors.lastname: Loos
authors.forename: Roel C
authors.initials: RC
authors.lastname: van der Schors
authors.forename: Dustin
authors.initials: D
authors.lastname: Schetters
authors.forename: Anton N M
authors.initials: AN
authors.lastname: Schoffelmeer
authors.forename: August B
authors.initials: AB
authors.lastname: Smit
authors.forename: Huibert D
authors.initials: HD
authors.lastname: Mansvelder
authors.forename: Tommy
authors.initials: T
authors.lastname: Pattij
authors.forename: Sabine
authors.initials: S
authors.lastname: Spijker
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology*; D003072:Cognition Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology; D014029:Tobacco Use Disorder / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*