title: Silicone punctal plugs as an adjunctive therapy for open-angle glaucoma and ocular hypertension.
abstract: BACKGROUND
  Primary open-angle glaucoma is a progressive optic neuropathy that can cause an irreversible loss of vision. A reduction in intraocular pressure (IOP) is beneficial in slowing or halting its progression. Once-per-day monotherapy glaucoma medications, such as prostaglandin analogues, are effective in lowering IOP while maintaining patients' adherence. Achieving the desired target IOP often requires multiple medications. The present study evaluates punctal occlusion of both the inferior and superior puncta as an adjunctive therapy to travoprost ophthalmic solution 0.004% for patients with primary open-angle glaucoma or ocular hypertension in order to reduce IOP.
  
  
  METHODS
  Thirteen patients who were using travoprost 0.004% ophthalmic solution for the treatment of open-angle glaucoma or ocular hypertension received silicone punctal plugs in the superior and inferior puncta of one eye. After one month, the IOP was remeasured. The percentage change of the IOP from the baseline was analysed by using a paired sample t-test.
  
  
  RESULTS
  The mean baseline IOP was 19.82 ± 1.19 mmHg in the test eyes and 18.32 ± 1.11 mmHg in the control eyes. The mean IOP at the one-month visit was 18.23 ± 1.17 mmHg in the test eyes and 18.45 ± 1.04 mmHg in the control eyes. The test eyes demonstrated a decrease in IOP of 1.59 (± 0.95) mmHg from the baseline, or a 6.82 per cent decrease in the IOP from the baseline. The control eyes had an increase in IOP of 0.14 ± 0.77 mmHg from the baseline, or a 1.91 per cent increase in the IOP. The relative difference in the IOP between the test eyes and the control eyes at the one-month visit was 1.73 mmHg, or 8.74 per cent.
  
  
  CONCLUSIONS
  Based on the results of this study, punctal occlusion offers a statistically and clinically significant decrease in IOP when it is used as an adjunctive therapy to travoprost 0.004% for patients who are suffering from open-angle glaucoma or ocular hypertension.
authors.affiliation: Illinois College of Optometry, Chicago, Illinois 60616, USA. dopitz@ico.edu
authors.forename: Dominick L
authors.initials: DL
authors.lastname: Opitz
authors.forename: Sherman
authors.initials: S
authors.lastname: Tung
authors.forename: Unsun Sarah
authors.initials: US
authors.lastname: Jang
authors.forename: Jenny J
authors.initials: JJ
authors.lastname: Park
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003008:Cloprostenol / Q000031:analogs & derivatives / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D009798:Ocular Hypertension / Q000188:drug therapy / Q000601:surgery*; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D012828:Silicones / Q000627:therapeutic use*; D000069557:Travoprost
chemical_list: D000959:Antihypertensive Agents; D012828:Silicones; D003008:Cloprostenol; D000069557:Travoprost