title: Enhanced absorption of millimeter wave energy in murine subcutaneous blood vessels.
abstract: The aim of the present study was to determine millimeter wave (MMW) absorption by blood vessels traversing the subcutaneous fat layer of murine skin. Most calculations were performed using the finite-difference time-domain (FDTD) technique. We used two types of models: (1) a rectangular block of multilayer tissue with blood vessels traversing the fat layer and (2) cylindrical models with circular and elliptical cross-sections simulating the real geometry of murine limbs. We found that the specific absorption rate (SAR) in blood vessels normally traversing the fat layer achieved its maximal value at the parallel orientation of the E-field to the vessel axis. At 42 GHz exposure, the maximal SAR in small blood vessels could be more than 30 times greater than that in the skin. The SAR increased with decreasing the blood vessel diameter and increasing the fat thickness. The SAR decreased with increasing the exposure frequency. When the cylindrical or elliptical models of murine limbs were exposed to plane MMW, the greatest absorption of MMW energy occurred in blood vessels located on the lateral areas of the limb model. At these areas the maximal SAR values were comparable with or were greater than the maximal SAR on the front surface of the skin. Enhanced absorption of MMW energy by blood vessels traversing the fat layer may play a primary role in initiating MMW effects on blood cells and vasodilatation of cutaneous blood vessels.
authors.affiliation: Center for Biomedical Physics, Temple University Medical School, Philadelphia, Pennsylvania 19140, USA.
authors.forename: Stanislav I
authors.initials: SI
authors.lastname: Alekseev
authors.forename: Marvin C
authors.initials: MC
authors.lastname: Ziskin
mesh_terms: D000042:Absorption; D000818:Animals; D001808:Blood Vessels / Q000528:radiation effects*; D003198:Computer Simulation; D066298:In Vitro Techniques; D051379:Mice; D000078702:Radiofrequency Therapy; D012867:Skin / Q000528:radiation effects; D050151:Subcutaneous Fat / Q000098:blood supply* / Q000528:radiation effects*