title: Cerebral peritumoral oedema study: does a single dynamic MR sequence assessing perfusion and permeability can help to differentiate glioblastoma from metastasis?
abstract: Our purpose was to differentiate glioblastoma from metastasis using a single dynamic MR sequence to assess perfusion and permeability parameters. 24 patients with glioblastoma or cerebral metastasis with peritumoral oedema were recruited and explored with a 3T MR unit. Post processing used DPTools software. Regions of interest were drawn around contrast enhancement to assess relative cerebral blood volume and permeability parameters. Around the contrast enhancement Glioblastoma present high rCBV with modification of the permeability, metastasis present slight modified rCBV without modification of permeability. In conclusion, peritumoral T2 hypersignal exploration associating morphological MR and functional MR parameters can help to differentiate cerebral metastasis from glioblastoma.
authors.affiliation: Neuroradiology, Amiens University Hospital, 1 Place Victor Pauchet, 80054 Amiens Cedex 1, France. pierre.lehmann@ah-hm.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Lehmann
authors.forename: Guillaume
authors.initials: G
authors.lastname: Saliou
authors.forename: Giovanni
authors.initials: G
authors.lastname: de Marco
authors.forename: Pauline
authors.initials: P
authors.lastname: Monet
authors.forename: Stoquart-Elsankari
authors.initials: SE
authors.lastname: Souraya
authors.forename: Alexis
authors.initials: A
authors.lastname: Bruniau
authors.forename: Jean Noel
authors.initials: JN
authors.lastname: Vallée
authors.forename: Denis
authors.initials: D
authors.lastname: Ducreux
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001929:Brain Edema / Q000175:diagnosis* / Q000473:pathology; D001932:Brain Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000556:secondary*; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D005909:Glioblastoma / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D003287:Contrast Media