title: 5-HT(4) receptors, a place in the sun: act two.
abstract: 5-HT(4) receptors control brain physiological functions such as learning and memory, feeding and mood behaviour as well as gastro-intestinal transit. 5-HT(4) receptors are one of the 5-HT receptors for which the available drugs and signalling knowledge are the most advanced. Several therapeutic 5-HT(4) receptor drugs have been commercialized. Therefore, the hope that 5-HT(4) receptors could also be the target for brain diseases is reasonable. Several major devastating illnesses could benefit from 5-HT(4) receptors-directed therapy such as Alzheimer's disease, feeding-associated diseases such as anorexia and major depressive disorders.
authors.affiliation: Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS UMR5203, Montpellier F-34094, France. joel.bockaert@igf.cnrs.fr
authors.forename: Joël
authors.initials: J
authors.lastname: Bockaert
authors.forename: Sylvie
authors.initials: S
authors.lastname: Claeysen
authors.forename: Valérie
authors.initials: V
authors.lastname: Compan
authors.forename: Aline
authors.initials: A
authors.lastname: Dumuis
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D001927:Brain Diseases / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D044422:Receptors, Serotonin, 5-HT4 / Q000378:metabolism*; D058828:Serotonin 5-HT4 Receptor Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D058832:Serotonin 5-HT4 Receptor Antagonists / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D058828:Serotonin 5-HT4 Receptor Agonists; D058832:Serotonin 5-HT4 Receptor Antagonists; D044422:Receptors, Serotonin, 5-HT4