title: Translational systems biology of inflammation: potential applications to personalized medicine.
abstract: A central goal of industrialized nations is to provide personalized, preemptive and predictive medicine, while maintaining healthcare costs at a minimum. To do so, we must confront and gain an understanding of inflammation, a complex, nonlinear process central to many diseases that affect both industrialized and developing nations. Herein, we describe the work aimed at creating a rational, engineering-oriented and evidence-based synthesis of inflammation geared towards rapid clinical application. This comprehensive approach, which we call 'Translational Systems Biology', to date has been utilized for in silico studies of sepsis, trauma/hemorrhage/traumatic brain injury, acute liver failure and wound healing. This framework has now allowed us to suggest how to modulate acute inflammation in a rational and individually optimized fashion using engineering principles applied to a biohybrid device. We suggest that we are on the cusp of fulfilling the promise of in silico modeling for personalized medicine for inflammatory disease.
authors.affiliation: Center for Inflammation & Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Mi
authors.forename: Nicole Yee-Key
authors.initials: NY
authors.lastname: Li
authors.forename: Cordelia
authors.initials: C
authors.lastname: Ziraldo
authors.forename: Ali
authors.initials: A
authors.lastname: Ghuma
authors.forename: Maxim
authors.initials: M
authors.lastname: Mikheev
authors.forename: Robert
authors.initials: R
authors.lastname: Squires
authors.forename: David O
authors.initials: DO
authors.lastname: Okonkwo
authors.forename: Katherine
authors.initials: K
authors.lastname: Verdolini-Abbott
authors.forename: Gregory
authors.initials: G
authors.lastname: Constantine
authors.forename: Gary
authors.initials: G
authors.lastname: An
authors.forename: Yoram
authors.initials: Y
authors.lastname: Vodovotz