title: Promise and pitfalls of the Immunochip.
abstract: Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of common and rare variants to map the remaining heritability and to fine-map established loci, the Immunochip Consortium has developed a 200,000 SNP chip that has been produced in very large numbers for a fraction of the cost of GWAS chips. This chip provides a powerful tool for immunogenetics gene mapping.
authors.affiliation: University of Queensland Diamantina Institute, Brisbane, Queensland, Australia.
authors.forename: Adrian
authors.initials: A
authors.lastname: Cortes
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Brown
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D055106:Genome-Wide Association Study; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D020641:Polymorphism, Single Nucleotide