title: Improvement in left ventricular systolic dyssynchrony in hypertensive patients after treatment of hypertension.
abstract: OBJECTIVE
  Left ventricular (LV) dyssynchrony has been commonly detected among hypertensive patients with normal LV systolic function and no evidence of congestive heart failure. The purpose of our study was to assess the changes in LV systolic dyssynchrony (SDS(LV)) among hypertensive patients after antihypertensive treatment, and to determine the relationship between SDS(LV) and other conventional echocardiographic parameters.
  
  
  METHODS
  Forty one hypertensive patients with normal LV ejection fraction were enrolled. By performing a conventional echocardiographic study, the SDS(LV) was measured as the time difference between the shortest and longest time of the peak myocardial systolic velocities among 12 segments of the basal and mid-levels of the 3 apical views, and radial dyssynchrony of the basal (RDS(base)) and mid-levels (RDS(mid)) measured as the time difference between the earliest and latest peak values on the radial strain curves of each level of the parasternal short-axis views.
  
  
  RESULTS
  Compared to baseline after six months of antihypertensive treatment, the SDS(LV) improved significantly (48.7±37.9 ms vs. 29.5±34.1 ms, p=0.020). Also the RDS(base) and RDS(mid) improved significantly in respect to the baseline values (129.9±136.3 ms vs. 38.8±45.4 ms, p=0.002 and 75.2±63.8 ms vs. 28.2±37.7 ms, respectively, p<0.001).
  
  
  CONCLUSIONS
  The severity of SDS(LV) improved with antihypertensive treatment, and was associated with the regression of LV mass. Furthermore, it might precede improvement in the mitral inflow pattern, as assessed by conventional echocardiography, so that early detection of the benefit of antihypertensive treatment may be possible.
authors.affiliation: Department of Cardiology, Fatima General Hospital, Daegu, Korea.
authors.forename: Byung Seok
authors.initials: BS
authors.lastname: Bae
authors.forename: Ki Ju
authors.initials: KJ
authors.lastname: Kim
authors.forename: Jung Gil
authors.initials: JG
authors.lastname: Park
authors.forename: Yeoun Su
authors.initials: YS
authors.lastname: Jung
authors.forename: Han Jun
authors.initials: HJ
authors.lastname: Ryu
authors.forename: Hyun Jae
authors.initials: HJ
authors.lastname: Kang
authors.forename: Bong Ryeol
authors.initials: BR
authors.lastname: Lee
authors.forename: Byung Chun
authors.initials: BC
authors.lastname: Jung