title: Effects of Urtica dioica on hepatic ischemia-reperfusion injury in rats.
abstract: OBJECTIVE
  To evaluate the effects of Urtica dioica on hepatic ischemia-reperfusion injury.
  
  
  METHODS
  Thirty adult male Wistar albino rats were divided into three groups: sham group (group 1), control group (group 2), and Urtica dioica group (group 3). All the rats were exposed to hepatic ischemia for 60 min, followed by 60 min of reperfusion. In group 2, a total of 2 ml/kg 0.9% saline solution was given intraperitoneally. In group 3, a total of 2 ml/kg Urtica dioica was given intraperitoneally. At the end of the procedure, liver tissue and blood samples were taken from all rats. Serum aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, ceruloplasmin, catalase, paraoxonase, arylesterase, and lipid hydroperoxide levels were measured. Liver tissue histopathologies were also evaluated by light microscopy.
  
  
  RESULTS
  Serum aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were significantly higher in group 2 than in group 1, and significantly lower in group 3 than in group 2. Also, group 2 had higher serum lipid hydroperoxides and ceruloplasmin levels but lower catalase, paraoxonase, and arylesterase levels than group 1. In group 3, serum lipid hydroperoxides and ceruloplasmin levels were significantly lower, and catalase, paraoxonase, and arylesterase levels were higher than those in group 2. Histopathological examination showed that liver tissue damage was significantly decreased in group 3 compared with group 2.
  
  
  CONCLUSIONS
  Urtica dioica has a protective effect on the liver in hepatic ischemia-reperfusion-injured rats.
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Duzce University, Duzce, Turkey. hayatikandis@yahoo.com
authors.forename: Hayati
authors.initials: H
authors.lastname: Kandis
authors.forename: Sami
authors.initials: S
authors.lastname: Karapolat
authors.forename: Umran
authors.initials: U
authors.lastname: Yildirim
authors.forename: Ayhan
authors.initials: A
authors.lastname: Saritas
authors.forename: Suat
authors.initials: S
authors.lastname: Gezer
authors.forename: Ramazan
authors.initials: R
authors.lastname: Memisogullari
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis; D004195:Disease Models, Animal; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood / Q000188:drug therapy*; D026982:Urtica dioica
chemical_list: D015415:Biomarkers; D008054:Lipid Peroxides; D010936:Plant Extracts; D007770:L-Lactate Dehydrogenase; D002570:Ceruloplasmin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase