title: Cardiac and neuroprotection regulated by α(1)-adrenergic receptor subtypes.
abstract: Sympathetic nervous system regulation by the α(1)-adrenergic receptor (AR) subtypes (α(1A), α(1B), α(1D)) is complex, whereby chronic activity can be either detrimental or protective for both heart and brain function. This review will summarize the evidence that this dual regulation can be mediated through the different α(1)-AR subtypes in the context of cardiac hypertrophy, heart failure, apoptosis, ischemic preconditioning, neurogenesis, locomotion, neurodegeneration, cognition, neuroplasticity, depression, anxiety, epilepsy, and mental illness.
authors.affiliation: Department of Molecular Cardiology, NB50, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. perezd@ccf.org
authors.forename: Dianne M
authors.initials: DM
authors.lastname: Perez
authors.forename: Van A
authors.initials: VA
authors.lastname: Doze
mesh_terms: D000818:Animals; D019610:Cytoprotection; D006801:Humans; D009206:Myocardium / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D020011:Protective Agents / Q000145:classification / Q000378:metabolism*; D018340:Receptors, Adrenergic, alpha-1 / Q000145:classification* / Q000235:genetics / Q000378:metabolism*
chemical_list: D020011:Protective Agents; D018340:Receptors, Adrenergic, alpha-1