title: [Encounter of cancer cells with bone. Cancer and inflammation--input and output of NF-κB - ].
abstract: NF-κB activation is frequently found in a variety of tumors, especially in those that are resistant to chemotherapy. The malignant phenotypes of tumor cells that are required for invasion and metastasis could be established by the output of NF-κB signaling including interactions with white blood cells, anti-apoptosis and angiogenesis. Consequently, by utilizing the similar mechanisms for immune cells to migrate through the body, tumor cells migrate via blood stream, survive against selective pressures in other organs they stop by, achieve re-growth as metastasis, or make a clinical relapse by traveling back to the primary site.
authors.affiliation: Department of pharmacology, Tokyo Women's Medical University.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Maru
mesh_terms: D050882:CREB-Binding Protein / Q000502:physiology; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D006801:Humans; D000860:Hypoxia; D007249:Inflammation; D008024:Ligands; D016328:NF-kappa B / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology / Q000473:pathology; D009389:Neovascularization, Pathologic; D017382:Reactive Oxygen Species; D015398:Signal Transduction; D051197:Toll-Like Receptor 4 / Q000502:physiology; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D008024:Ligands; D016328:NF-kappa B; D017382:Reactive Oxygen Species; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; D014409:Tumor Necrosis Factor-alpha; D050882:CREB-Binding Protein