title: Outcomes of renal transplantation in patients with autosomal dominant polycystic kidney disease: a nationwide longitudinal study.
abstract: Renal transplantation in patients with autosomal dominant polycystic kidney disease (ADPKD) is a medical and surgical challenge. Detailed longitudinal epidemiological studies on large populations are lacking and it is mandatory to care better for these patients. The success of such a project requires the development of a validated epidemiological database. Herein, we present the results of the largest longitudinal study to date on renal transplant in patients with ADPKD. The 15-year outcomes following renal transplantation of 534 ADPKD patients were compared with 4779 non-ADPKD patients. This comprehensive, longitudinal, multicenter French study was performed using the validated database, DIVAT (Données Informatisées et VAlidées en Transplantaion). We demonstrate that renal transplantation in ADPKD is associated with better graft survival, more thromboembolic complications, more metabolic complications, and increased incidence of hypertension, whereas the prevalence of infections is not increased. This study provides important new insights that could lead to a better care for renal transplant patients with ADPKD.
authors.affiliation: Nephrology and Renal Transplantation Department, Bicetre Hospital, Paris, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Jacquet
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pallet
authors.forename: Michèle
authors.initials: M
authors.lastname: Kessler
authors.forename: Maryvonne
authors.initials: M
authors.lastname: Hourmant
authors.forename: Valérie
authors.initials: V
authors.lastname: Garrigue
authors.forename: Lionel
authors.initials: L
authors.lastname: Rostaing
authors.forename: Henri
authors.initials: H
authors.lastname: Kreis
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Mamzer-Bruneel
mesh_terms: D000328:Adult; D016208:Databases, Factual; D003920:Diabetes Mellitus / Q000209:etiology; D005260:Female; D005602:France / Q000453:epidemiology; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000401:mortality; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D011655:Pulmonary Embolism / Q000209:etiology; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000209:etiology