title: Cardiac arrhythmia induced by interferon beta-1a.
abstract: Cardiac adverse effects have never been reported with interferon (INF) beta. We report a case of left bundle branch block in a 35-year-old woman treated with INF beta-1a for multiple sclerosis. Five years after INF therapy, she presented loss of consciousness, retrosternal pains, short breath and lowered tolerance of effort. ECG and Holter 24-h ECG monitoring revealed permanent complete left bundle branch block. Nine months after stopping INF, no abnormalities were found at ECG and echocardiogram examination.
authors.affiliation: Service de recueil et analyse des effets indésirables, Centre National de Pharmacovigilance, 9 Av Dr Zouheir Essafi 1006 Tunis, Tunisia.
authors.forename: Sarrah
authors.initials: S
authors.lastname: Kastalli
authors.forename: Sihem
authors.initials: S
authors.lastname: El Aïdli
authors.forename: Sami
authors.initials: S
authors.lastname: Mourali
authors.forename: Ahmed
authors.initials: A
authors.lastname: Zaïem
authors.forename: Riadh
authors.initials: R
authors.lastname: Daghfous
authors.forename: Mohamed
authors.initials: M
authors.lastname: Lakhal
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D002037:Bundle-Branch Block / Q000139:chemically induced*; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000009:adverse effects* / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy
chemical_list: D000276:Adjuvants, Immunologic; D016899:Interferon-beta; D000068556:Interferon beta-1a