title: Primary diffuse large B-cell lymphoma of the lacrimal sac simulating chronic dacryocystitis.
abstract: Primary diffuse large B-cell lymphoma of the lacrimal sac is rare. Herein we report a 55-year-old female presented with epiphora in the right eye. Distention of the lacrimal sac secondary to nasolacrimal duct obstruction was observed. She was scheduled for external dacryocystorinostomy for the next month. When she came for surgery, a growing mass was recognised over the lacrimal sac region. On computer tomography scan, a subdermal mass causing nasal bone destruction was detected. Excisional biopsy of the mass was performed. Histopathologic and immunohistochemical evaluations revealed primary diffuse large B-cell non-Hodgkin lymphoma of the lacrimal sac. She was treated with cyclophospamide, vincristine, adriablastine and prednisone for eight courses combined with rituximab for 6 months. During a follow-up period of 25 months, patient is stable with no systemic disease. Although rare, lacrimal sac tumors can mimic dacryocystitis and must be considered in differential diagnosis. In suspicious cases incisional biopsy is recommended.
authors.affiliation: Ege University Faculty of Medicine, Department of Ophthalmology, Izmir, Turkey.
authors.forename: Melis
authors.initials: M
authors.lastname: Palamar
authors.forename: Rasit
authors.initials: R
authors.lastname: Midilli
authors.forename: Nazan
authors.initials: N
authors.lastname: Ozsan
authors.forename: Sait
authors.initials: S
authors.lastname: Egrilmez
authors.forename: Fahri
authors.initials: F
authors.lastname: Sahin
authors.forename: Ayse
authors.initials: A
authors.lastname: Yagci
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002908:Chronic Disease; D003607:Dacryocystitis / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000175:diagnosis* / Q000188:drug therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab