title: The role of alpha adrenoceptors in the vascular and estradiol secretory responses to stimulation of the superior ovarian nerve.
abstract: Electrical stimulation of the superior ovarian nerve in rats reduces both the plasma flow rate of ovarian venous blood (ovarian blood flow) and the ovarian estradiol secretion rate. Here, we examined the possible roles of alpha-adrenoceptors in these processes. The reduction of the plasma flow rate was blocked by an alpha 1- (prazosin), but not by an alpha 2- (yohimbine) adrenoceptor blocker. In contrast, the reduction of the estradiol secretion rate was blocked by yohimbine but not by prazosin. We conclude that ovarian vascular and estradiol secretory responses to superior ovarian nerve activation are mediated by alpha 1- and alpha 2-adrenoceptors, respectively.
authors.affiliation: Department of Autonomic Neuroscience, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan. fkagitan@tmig.or.jp
authors.forename: Fusako
authors.initials: F
authors.lastname: Kagitani
authors.forename: Sae
authors.initials: S
authors.lastname: Uchida
authors.forename: Harumi
authors.initials: H
authors.lastname: Hotta
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology; D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004558:Electric Stimulation / Q000379:methods; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D009131:Muscle, Smooth, Vascular / Q000098:blood supply / Q000294:innervation / Q000378:metabolism*; D010053:Ovary / Q000098:blood supply / Q000294:innervation / Q000378:metabolism / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D018340:Receptors, Adrenergic, alpha-1; D018341:Receptors, Adrenergic, alpha-2; D011943:Receptors, Adrenergic, beta; D015016:Yohimbine; D004958:Estradiol; D011224:Prazosin