title: Anastrozole versus clomiphene citrate: which is better for ovulation induction?
abstract: Although anastrozole may be used as an oral therapeutic agent in ovulation induction, it is not recommended as a replacement for clomiphene citrate. On the basis of two phase 2 studies, anastrozole should be viewed as a second-tier therapy after clomiphene citrate in anovulatory patients.
authors.affiliation: Global Clinical Development Unit, EMD Serono, Inc., Rockland, Massachusetts 02370, USA.
authors.forename: Donald R
authors.initials: DR
authors.lastname: Tredway
authors.forename: Joan C
authors.initials: JC
authors.lastname: Schertz
mesh_terms: D000077384:Anastrozole; D047072:Aromatase Inhibitors / Q000627:therapeutic use; D017322:Clinical Trials, Phase II as Topic; D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D009570:Nitriles / Q000627:therapeutic use*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D047072:Aromatase Inhibitors; D005300:Fertility Agents, Female; D009570:Nitriles; D014230:Triazoles; D002996:Clomiphene; D000077384:Anastrozole