title: [Encounter of cancer cells with bone. Development of cancer therapy targeted on acidic microenvironment and acidic organelle of cancer cells].
abstract: Recent study revealed that most of cancer cells form acidic environment and have many, large size acidic organelle, especially lysosomes due to cancer specific proton dynamics induced by active aerobic glycolysis without TCA cycle in the mitochondoria. We have developed a new cancer therapy with acridine orange photodynamics which targeted on such cancer acidity and treated patients with malignant bone and soft tissue tumors. In this paper, we describe mechanism and clinical outcome of the therapy.
authors.affiliation: Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kusuzaki
mesh_terms: D000165:Acridine Orange / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D006019:Glycolysis; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D010778:Photochemotherapy; D011522:Protons; D011879:Radiotherapy Dosage
chemical_list: D011522:Protons; D019344:Lactic Acid; D000165:Acridine Orange