title: [Metabolic syndrome and insulin resistance in patients with chronic hepatitis C].
abstract: OBJECTIVE
  To estimate the incidence and clinical value of metabolic syndrome, insulin resistance, and steatosis in patients with chronic hepatitis C (CHC) caused by its virus genotype 1.
  
  
  METHODS
  One hundred and fourteen patients (67 men and 47 women; mean age 44.9 +/- 13.3 years) were examined.
  
  
  RESULTS
  There were high incidence rates of metabolic syndrome (47.2%) and insulin resistance (50%), in the genesis of which the host-virus interaction is discussed. There was an independent correlation of the insulin resistance and elevated leptin levels with abdominal obesity and hepatic steatosis; however, these indicators did not correlate with the stage of fibrosis. At the same time hepatic steatosis (found in 38% of the patients) and its degree correlated with the stage of fibrosis. Thirty-four of 66 (54.5%) patients receiving antiviral therapy achieved a stable virological response.
  
  
  CONCLUSIONS
  Obesity, hyperglycemia, and significant insulin resistance along with the stage of hepatic cirrhosis are independent cofactors that determine no treatment response.
authors.forename: Zh Zh
authors.initials: ZhZh
authors.lastname: Baĭzhanova
authors.forename: T M
authors.initials: TM
authors.lastname: Ignatova
authors.forename: T P
authors.initials: TP
authors.lastname: Nekrasova
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology / Q000378:metabolism; D005234:Fatty Liver / Q000150:complications / Q000453:epidemiology / Q000378:metabolism; D005260:Female; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism* / Q000821:virology; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology* / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000378:metabolism; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D020738:Leptin