title: [Takotsubo syndrome. Usefulness of nuclear medicine studies].
abstract: Takotsubo syndrome can mimic an acute myocardial infarction. It is characterized by anginal chest pain with ST elevation in precordial leads, no coronary obstruction on angiography, and typical and reversible deformation of the left ventricular due to antero-apical ballooning with basal hyperkinesis. The pathophysiology of this syndrome is uncertain. It is probably multifactorial, cardiac adrenergic nervous dysfunction standing out in the acute phase. We report two cases performed within the diagnostic context of Takotsubo syndrome. Cardiac SPECT was performed using (123)I Metaiodobenzylguanidine (MIBG) and (99m)Tc-Tetrofosmin and the results of two cases were adrenergic denervation in the anterior wall without alterations in myocardial perfusion study. Identification of Takotsubo syndrome is of clinical importance because its management and prognosis differ significantly from that of acute myocardial infarction.
authors.affiliation: Servicio de Medicina Nuclear, SESCAM, Hospital General Virgen de la Luz, Cuenca, Spain.
authors.forename: L M
authors.initials: LM
authors.lastname: Mena
authors.forename: F
authors.initials: F
authors.lastname: Martín
authors.forename: A
authors.initials: A
authors.lastname: Melero
authors.forename: A
authors.initials: A
authors.lastname: Ramos
authors.forename: I R
authors.initials: IR
authors.lastname: Jiménez
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D006328:Cardiac Catheterization; D002395:Catecholamines / Q000378:metabolism; D002637:Chest Pain / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology; D006349:Heart Valve Diseases / Q000150:complications; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000294:innervation / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000175:diagnosis; D009638:Norepinephrine / Q000378:metabolism; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012214:Rheumatic Heart Disease / Q000150:complications; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology; D054549:Takotsubo Cardiomyopathy / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D002395:Catecholamines; D007457:Iodine Radioisotopes; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine; C078700:technetium tc-99m tetrofosmin; D009638:Norepinephrine