title: Leaf essential oil of Manekia naranjoana (Piperaceae) from Costa Rica and its cytotoxic activity.
abstract: The chemical composition of the leaf oil of Manekia naranjoana (C. DC.) Callejas (Piperaceae) from Costa Rica was analyzed by capillary GC/FID and GC/MS. Fifty-five compounds were identified. Major compounds from the leaf oil were beta-pinene (30.6%), alpha-pinene (18.8%), limonene (13.7%), and beta-caryophyllene (6.1%). The oil presented very low toxicity to tumor and non-tumor cell lines, even though it contains components, such as alpha- and beta-pinene, limonene and others, which have been shown to be cytotoxic. This is the first report of the chemical composition of the essential oil obtained from this species.
authors.affiliation: Centro de Investigaciones en Productos Naturales and Escuela de Química, Universidad de Costa Rica, San José, Montes de Oca, San Pedro, 11501-2060 Costa Rica.
authors.forename: Carlos
authors.initials: C
authors.lastname: Chaverri
authors.forename: Cecilia
authors.initials: C
authors.lastname: Díaz
authors.forename: José F
authors.initials: JF
authors.lastname: Cicció
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003364:Costa Rica; D006801:Humans; D009822:Oils, Volatile / Q000032:analysis* / Q000633:toxicity; D026321:Piperaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D009822:Oils, Volatile