title: Toxic polyketides produced by Fusarium sp., an endophytic fungus isolated from Melia azedarach.
abstract: A new isocoumarin derivative named fusariumin (1), together with two known related resorcylic acid lactones aigialomycin D (2) and pochonin N (3), has been isolated from the cultures of Fusarium sp. LN-10, an endophytic fungus originated from the leaves of Melia azedarach. Their structures were established on the basis of extensive spectroscopic analyzes including 1D- and 2D- NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOESY) experiments. Compounds 1-3 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina).
authors.affiliation: Research Centre for Natural Medicinal Chemistry, College of Science, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Yang
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Gao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D000818:Animals; D003374:Coumarins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D003445:Crustacea / Q000187:drug effects; D005670:Fusarium / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D031585:Melia / Q000382:microbiology*; D018515:Plant Leaves / Q000382:microbiology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D003374:Coumarins; C559139:fusariumin