title: Association of subclinical hypothyroidism and phenotype, insulin resistance, and lipid parameters in young women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine whether subclinical hypothyroidism (SCH) alters the phenotype, insulin resistance, or lipid parameters in young women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Prospective case-control study.
  
  
  METHODS
  Tertiary care setting.
  
  
  METHODS
  Sixty-two young women with PCOS and SCH (group I) and 291 euthyroid women with PCOS (group II).
  
  
  METHODS
  Recording of clinical, biochemical, hormonal profile, and parameters of insulin resistance.
  
  
  METHODS
  Whether SCH has any association with clinical parameters like hirsutism, menstrual disturbances, lipid profile, and parameters of insulin sensitivity.
  
  
  RESULTS
  Mean (±SD) TSH was 7.13±1.28 IU/L in group I and 2.51±1.21 IU/L in group II, with comparable free triiodothyronine and free thyroxine. The two groups were comparable in age, weight, and body mass index. Parameters like blood pressure, menstrual pattern, and degree and duration of hirsutism did not differ between the two groups. Serum concentrations of triglycerides were significantly higher in the SCH group compared with controls. Plasma glucose concentrations both in fasting and after oral glucose tolerance test were similar between the two groups. Fasting insulin and other parameters of insulin resistance were not altered by SCH.
  
  
  CONCLUSIONS
  Mild TSH elevation in the face of normal serum free triiodothyronine and free thyroxine results in a mild increase in serum lipids. Subclinical hypothyroidism is not associated with alteration in phenotypic expression and insulin resistance in young women with PCOS.
authors.affiliation: Department of Endocrinology Sher-i-Kashmir Institute of Medical Sciences, Soura Srinagar, India. ashraf.endo@gmail.com
authors.forename: Mohd Ashraf
authors.initials: MA
authors.lastname: Ganie
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Laway
authors.forename: Tariq Ahmed
authors.initials: TA
authors.lastname: Wani
authors.forename: Mohd Afzal
authors.initials: MA
authors.lastname: Zargar
authors.forename: Sobia
authors.initials: S
authors.lastname: Nisar
authors.forename: Feroze
authors.initials: F
authors.lastname: Ahamed
authors.forename: M L
authors.initials: ML
authors.lastname: Khurana
authors.forename: Sanjeed
authors.initials: S
authors.lastname: Ahmed
mesh_terms: D000293:Adolescent; D000328:Adult; D058070:Asymptomatic Diseases; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications* / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology; D008055:Lipids / Q000097:blood*; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000378:metabolism*; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D008055:Lipids; D013963:Thyroid Hormones; D013972:Thyrotropin