title: [Synthesis and photochemical virus inactivation of novel phenothiazines].
abstract: Virus inactivation with photochemistry is being suitable for blood or blood products, methylene blue (MB)/light treatment has been used for viral inactivation of cellular blood components. Twelve new phenothiazines derivatives were designed and synthesized, and were used to test viral inactivation and red cell damage preliminary. Results showed that compound YWW-7 has a satisfactory activity, it could be developed as a new viral inactivation agent for blood products.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wen
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Jing-Xing
authors.initials: JX
authors.lastname: Wang
authors.forename: Guang-Zhong
authors.initials: GZ
authors.lastname: Yang
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008751:Methylene Blue / Q000031:analogs & derivatives / Q000737:chemistry; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D017319:Photosensitizing Agents / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D038301:Virus Inactivation / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D010640:Phenothiazines; D017319:Photosensitizing Agents; D008751:Methylene Blue