title: Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
authors.affiliation: Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. m-ishikawa@iam.u-tokyo.ac.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D016208:Databases, Factual; D055808:Drug Discovery; D057927:Hydrophobic and Hydrophilic Interactions; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations; D014867:Water