title: [The influence of tobacco smoking on concentration of the pregnancy-associated plasma protein A (PAPP-A) in pregnant women].
abstract: This article presents a review of scientific literature concerning adverse effect of tobacco smoking on concentration of the pregnancy-associated plasma protein A (PAPP-A) in pregnant women. PAPP-A is produced in great amounts during pregnancy by the syncytiotrofoblast, but can be also detected in a variety of cell types such as fibroblasts, osteoblasts and vascular smooth muscle cells (VSMC). We describe the structure of PAPP-A and its function as an insulin-like growth factor binding proteins (IGFBPs) protease with a focus on data obtained in tobacco smoking pregnant women. We also discuss the results of studies indicating a correlation between smoking and deficit of PAPP-A in the first trimester of pregnancy. The review summarizes possible mechanisms relating tobacco smoking to the changes of PAPP-A concentration during pregnancy.
authors.affiliation: Zakład Badań Przesiewowych, Pracownia Biochemii, Instytut Matki i Dziecka w Warszawie. biochem.imid@imid.med.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Gajewska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Chełchowska
authors.forename: Alicja
authors.initials: A
authors.lastname: Ceran
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Ambroszkiewicz
authors.forename: Teresa
authors.initials: T
authors.lastname: Laskowska-Klita
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000737:chemistry / Q000172:deficiency / Q000378:metabolism*; D012907:Smoking / Q000097:blood*
chemical_list: D011266:Pregnancy-Associated Plasma Protein-A