title: History of antisense oligonucleotides.
abstract: Biological science is a rapidly flowing experimental stream, at times encountering a dam that impedes further progress. At such a pomt, a single crack may induce a major breakthrough Discovery of the double helical structure of DNA in 1953 (1) caused such an event, with flooding of new information into the area now known as molecular biology.
authors.affiliation: Worcester Foundation for Biomedical Research, Shrewsbury, MA.
authors.forename: P C
authors.initials: PC
authors.lastname: Zamecnik