title: Serum antibody coupled with the construction of gentamicin sulfate for the Escherichia coli targeted drug.
abstract: Conjugates of the Escherichia coli serum antibody (Ab) with the gentamicin sulfate (GM sulfate) have been evaluated for the assessment of their ability to eradicate E. coli in vitro. The combination of every component in the targeted drug is the amino of serum antibody and gentamicin sulfate combined with the hydroxyl of PEG6000 by hydrogen bond, which forms stable complexes. The half-life of this complex is 4.83 h, and it is non-toxic side effects and low immunogenic. After the combination of antibody and gentamicin sulfate, the targeting of antibody is quite good. In vitro anti-bacterial activity of gentamicin sulfate increased 1000 times, and the clinical curative effect enhanced 100 times, this means higher efficacy and safety.
authors.affiliation: Animal Medicine College, Hunan Agriculture University, Changsha, Hunan 410128, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Chen
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.forename: Haitao
authors.initials: H
authors.lastname: Chen
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000907:Antibodies, Bacterial / Q000737:chemistry* / Q000276:immunology*; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy; D005839:Gentamicins / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D005839:Gentamicins