title: RAG-2 unleashed: lymphocytes beware.
abstract: The programmed degradation of the RAG-2 enzyme upon entry to S phase restricts V(D)J recombination to the G0-G1 phase of the cell cycle. In this issue of Immunity, Zhang et al. (2011) show that this is critical to prevent lymphoma formation.
authors.affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA. fugmanns@grc.nia.nih.gov
authors.forename: Sebastian D
authors.initials: SD
authors.lastname: Fugmann