title: Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis.
abstract: Heat shock protein (Hsp) 60 has been implicated in the pathogenesis of various inflammatory and autoimmune diseases. This study aimed to investigate synovial fluid and serum concentrations of Hsp60 and anti-Hsp60 and their relationship with juvenile idiopathic arthritis (JIA). Forty-eight patients with JIA, including 22 oligo-articular, 19 poly-articular, and 7 systemic diseases, and 33 normal controls were enrolled in this study. Synovial fluid and serum Hsp60 and anti-Hsp60 concentrations were measured via ELISA. Serum concentrations of Hsp60 of active and inactive oligo- and poly-articular JIA were significantly higher than those of normal controls. Serum concentration of anti-Hsp60 in active oligo-articular JIA was higher than that of normal controls (49.25 vs. 35.76 ng/mL, p = 0.059). Similarly, serum concentration of anti-Hsp60 in active poly-articular JIA was significantly higher than that of inactive samples (65.05 vs. 26.54 ng/mL, p = 0.008). In addition, serum concentration of Hsp60 correlated with the time required for remission from flare-ups in patients with JIA. Serum concentration of Hsp60 correlated well with time required for remission from flare-ups in patients with JIA, representing a potential disease marker to monitor disease activity.
authors.affiliation: Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, 5 Fu-Hsin Street, Kueishan, Taoyuan, Taiwan.
authors.forename: Chih-Te Charles
authors.initials: CT
authors.lastname: Wu
authors.forename: Liang-Shiou
authors.initials: LS
authors.lastname: Ou
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Yeh
authors.forename: Wen-I
authors.initials: WI
authors.lastname: Lee
authors.forename: Jing-Long
authors.initials: JL
authors.lastname: Huang
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D001323:Autoantibodies / Q000097:blood; D018834:Chaperonin 60 / Q000097:blood* / Q000276:immunology; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D018501:Antirheumatic Agents; D001323:Autoantibodies; D018834:Chaperonin 60