title: MMT, Npeoc-protected spermine, a valuable synthon for the solid phase synthesis of oligonucleotide oligospermine conjugates via guanidine linkers.
abstract: Solid phase spermine oligomerization via guanidine linkers was achieved using activated thiourea coupling reaction with primary amino group. Disymmetric spermine synthon was efficiently synthesised in eight steps from spermine. MMT group was used as coupling monitor and resulting oligomeric spermines were conjugated to oligonucleotides.
authors.affiliation: Laboratoire de Chimie Génétique, UMR7199 CAMB, CNRS et Université de Strasbourg, Faculté de Pharmacie, 67401 Illkirch, France.
authors.forename: Phanélie
authors.initials: P
authors.lastname: Perche
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Kotera
authors.forename: Jean-Serge
authors.initials: JS
authors.lastname: Remy
mesh_terms: D019791:Guanidine / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D013096:Spermine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D044366:Transition Temperature; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D014320:Triphenylmethyl Compounds; D013096:Spermine; D013890:Thiourea; D019791:Guanidine