title: Relations of circulating resistin and adiponectin and cardiac structure and function: the Framingham Offspring Study.
abstract: Obesity is associated with pathological cardiac remodeling and risk of heart failure (HF). Adipocytokines (ADKs) may mediate the increased risk of cardiovascular disease associated with excess adiposity. Yet data relating ADKs to cardiac remodeling phenotypes are sparse. We related two circulating ADKs, resistin and adiponectin, to three important echocardiographic markers of cardiac remodeling, left ventricular mass (LVM), left atrial diameter (LAD), and LV fractional shortening (LVFS) in 2,615 participants (mean age 61 years, 55% women) in the Framingham Offspring Study. Adiponectin concentrations were inversely related to LVM in multivariable linear regression models adjusting for key clinical correlates including BMI (regression coefficient per s.d.-increment in ln-adiponectin = -3.37, P = 0.02; P for trend across quartiles = 0.02). Adiponectin was not associated with LAD or LVFS (P > 0.56). Resistin concentrations were inversely related to LVFS (regression coefficient per s.d.-increment in ln-resistin = -0.01, P = 0.03; P for trend across quartiles = 0.04). Resistin was not associated with LVM or LAD (P > 0.05). In our moderate-sized, community-based sample, higher circulating concentrations of adiponectin and resistin were associated with lower LVM and lower LVFS, respectively. In conclusion, these associations identify potential mechanisms by which excess adiposity may mediate adverse cardiac remodeling and HF risk.
authors.affiliation: National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
authors.forename: David D
authors.initials: DD
authors.lastname: McManus
authors.forename: Asya
authors.initials: A
authors.lastname: Lyass
authors.forename: Erik
authors.initials: E
authors.lastname: Ingelsson
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Massaro
authors.forename: James B
authors.initials: JB
authors.lastname: Meigs
authors.forename: Jayashri
authors.initials: J
authors.lastname: Aragam
authors.forename: Emelia J
authors.initials: EJ
authors.lastname: Benjamin
authors.forename: Ramachandran S
authors.initials: RS
authors.lastname: Vasan
mesh_terms: D052242:Adiponectin / Q000097:blood*; D016279:Atrial Function, Left / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D002302:Cardiac Output; D003153:Community Health Services; D004452:Echocardiography; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology* / Q000503:physiopathology; D010375:Pedigree; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D016277:Ventricular Function, Left / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D052243:Resistin