title: Cyclopentyl methyl ether: an alternative solvent for palladium-catalyzed direct arylation of heteroaromatics.
abstract: Some ethers, such as cyclopentyl methyl ether and di-n-butyl ether, which can be considered as "greener" solvents than N,N-dimethylacetamide (DMAc) or DMF, can be advantageously employed for the palladium-catalyzed direct arylation of heteroaromatics. In the presence of such ethers and only 0.5-1 mol % of palladium catalysts at 125-150 °C, the direct 5-arylation of thiazoles, thiophenes, or furans by using aryl bromides as coupling partners proceeds in moderate to high yields.
authors.affiliation: Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, Catalyse et Organometalliques, Campus de Beaulieu, 35042 Rennes, France.
authors.forename: Kassem
authors.initials: K
authors.lastname: Beydoun
authors.forename: Henri
authors.initials: H
authors.lastname: Doucet
mesh_terms: D002384:Catalysis; D055772:Green Chemistry Technology / Q000379:methods*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008738:Methyl Ethers / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D008738:Methyl Ethers; D012997:Solvents; D010165:Palladium