title: Toward the synthesis and biological screening of a cyclotetrapeptide from marine bacteria.
abstract: The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl-alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-L-Pro-L-Leu-OH and L-Ala-L-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms.
authors.affiliation: Department of Pharmaceutical Chemistry, NRI Institute of Pharmacy, Bhopal 462 021, Madhya Pradesh, India. drrajivdahiya@rediffmail.com
authors.forename: Rajiv
authors.initials: R
authors.lastname: Dahiya
authors.forename: Hemendra
authors.initials: H
authors.lastname: Gautam
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D059001:Aquatic Organisms; D003500:Cyclization; D004151:Dipeptides / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009792:Oceans and Seas; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011161:Porifera / Q000382:microbiology; D031161:Pseudoalteromonas / Q000737:chemistry*; D011549:Pseudomonas / Q000737:chemistry*; D012624:Seaweed / Q000382:microbiology
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D004151:Dipeptides; D009842:Oligopeptides; D010456:Peptides, Cyclic