title: The potential role of ATF3 on immune response is regulated by BMP10 through Smad dependent pathway.
abstract: It is hypothesis that ATF3 is a downstream component of BMP10. The possible function of ATF3 on immune response is partially regulated by BMP10 via Smad dependent pathway. BMP10 is highly expressed in blood cells during embryonic development based on our in situ hybridization. The expression of ATF3 is enhanced by BMP10 in overexpression transgenic mice. Both BMP10 and ATF3 can response to stress stimulate, and ATF3 is well understood as a stress inducible gene which possible contributes to immune response. The Smad dependent pathway is well established for BMP10 in regulation expression of downstream targets. It would be interesting for us to determine the relationship between BMP10 and ATF3, especially to understand the mechanism of BMP10 and ATF3 effecting on heart development, as well as immune response exposed to stress stimulates.
authors.affiliation: The National Key Laboratory for Biotherapy, Laboratory of Cardiovascular Disease, West China Hospital, Sichuan University, Cheng du 610041, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Hong-bo
authors.initials: HB
authors.lastname: Xin
mesh_terms: D051700:Activating Transcription Factor 3 / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D005091:Exons; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D006801:Humans; D007107:Immune System; D017403:In Situ Hybridization; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D008957:Models, Genetic; D008962:Models, Theoretical; D020411:Oligonucleotide Array Sequence Analysis; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism*
chemical_list: D051700:Activating Transcription Factor 3; C541386:BMP10 protein, human; D019485:Bone Morphogenetic Proteins; D051785:Smad Proteins