title: The relationship between cord blood immunoglobulin E levels and allergy-related outcomes in young adults.
abstract: BACKGROUND
  Elevated cord blood IgE may be associated with a higher risk of allergic disease.
  
  
  OBJECTIVE
  To determine whether cord blood IgE is associated with allergic biomarkers or allergic disorders in young adults.
  
  
  METHODS
  Data was collected from 670 subjects 18-21 years of age that were among 835 original participants in the Detroit Childhood Allergy Study, a general risk, population-based birth cohort. Cord blood IgE was assessed in relation to biomarkers associated with allergy and asthma including total IgE, allergen-specific IgE, blood eosinophilia, and spirometry. Cord blood IgE was also analyzed for associations to subsequent allergic disease including atopic dermatitis, allergic rhinitis, and asthma.
  
  
  RESULTS
  Cord blood IgE, analyzed as a continuous measure, was modestly correlated with total IgE (r = 0.18, P < .001) and higher cord IgE was associated with a higher likelihood of sensitization to common allergens in young adults (OR = 1.18, 95% CI, 1.02-1.37; P = .031). The relationship between cord IgE and sensitization was stronger among teens with no pet exposure in the first year of life (OR = 1.43, 95% CI, 1.16-1.77; P = .001). No relationship was found between cord IgE and blood eosinophil counts or lung function. In addition, no consistent association of cord blood IgE to asthma, allergic rhinitis, or atopic dermatitis was apparent.
  
  
  CONCLUSIONS
  An elevated cord blood IgE level modestly correlates with elevated total IgE and is associated with a slightly higher likelihood of allergic sensitization among young adults. However, cord IgE is not a strong predictor of clinical allergic disorders in this age group.
authors.affiliation: Division of Allergy and Clinical Immunology, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
authors.forename: Purvee S
authors.initials: PS
authors.lastname: Shah
authors.forename: Ganesa
authors.initials: G
authors.lastname: Wegienka
authors.forename: Suzanne
authors.initials: S
authors.lastname: Havstad
authors.forename: Christine Cole
authors.initials: CC
authors.lastname: Johnson
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Ownby
authors.forename: Edward M
authors.initials: EM
authors.lastname: Zoratti
mesh_terms: D000293:Adolescent; D015331:Cohort Studies; D004802:Eosinophilia / Q000097:blood / Q000276:immunology; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood*; D007231:Infant, Newborn; D008824:Michigan; D013147:Spirometry; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D007073:Immunoglobulin E