title: Stevens-Johnson syndrome induced by acetazolamide.
abstract: Acetazolamide is a sulfonamide derivative and carbonic anhydrase inhibitor used to lower intraocular pressure in glaucomatous patients. Stevens-Johnson syndrome (SJS) toxic epidermal necrolysis (TEN) associated with acetazolamide treatment has been diagnosed in Japanese, Japanese-American and Indian patients. Herein, we report the second Korean case of SJS-TEN associated with acetazolamide treatment. The result of human leukocyte antigen (HLA) typing of our patient was positive for HLA-B59. According to recent research, HLA-B59 has been detected in SJS caused by metazolamide, which is analogous to acetazolamide. This suggests a possible relationship between genetic background and SJS-TEN-associated acetazolamide treatment. Theretofore, acetazolamide should be prescribed to Korean patients with the same discreet caution.
authors.affiliation: Department of Dermatology, College of Medicine, Hallym University, Seoul, Korea.
authors.forename: Young
authors.initials: Y
authors.lastname: Her
authors.forename: Min S
authors.initials: MS
authors.lastname: Kil
authors.forename: Ju H
authors.initials: JH
authors.lastname: Park
authors.forename: Chul W
authors.initials: CW
authors.lastname: Kim
authors.forename: Sang S
authors.initials: SS
authors.lastname: Kim
mesh_terms: D000086:Acetazolamide / Q000009:adverse effects*; D000328:Adult; D044466:Asian People / Q000235:genetics*; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects*; D005260:Female; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D015235:HLA-B Antigens; C082943:HLA-B59 antigen; D000086:Acetazolamide