title: Major depression, borderline personality disorder, and visceral fat content in women.
abstract: Major depressive disorder (MDD) is associated with increased volumes of visceral fat and a high prevalence of the metabolic syndrome. In turn, affective disorders are frequently found in patients with borderline personality disorder (BPD). It is therefore unclear whether BPD per se may influence body composition. In order to clarify a potential relationship between BPD and body composition, we measured visceral fat content (VFC) in young depressed women with and without comorbid BPD and related this parameter to various features of the metabolic syndrome. Visceral fat content was measured by magnetic resonance imaging in 22 premenopausal women with MDD only, in 44 women with comorbid MDD and BPD, in 12 female BPD patients without MDD, and in 34 healthy women (CG). Data showed that depressed women without comorbid BPD had a 335% higher VFC and women with comorbid BPD had a 250% higher VFC than the CG women. When controlling for age, data showed significant effects of MDD on VFC (F = 8.4; P = 0.005). However, BPD, with or without MDD, was not related to VFC. Young depressed women with and without comorbid BPD display increased visceral fat content when compared to control subjects and may therefore constitute a risk group for the development of the metabolic syndrome. BPD per se is not an additive risk factor in this context.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany. wiebke.greggersen@psychiatrie.uk-sh.de
authors.forename: Wiebke
authors.initials: W
authors.lastname: Greggersen
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rudolf
authors.forename: Eva
authors.initials: E
authors.lastname: Fassbinder
authors.forename: Leif
authors.initials: L
authors.lastname: Dibbelt
authors.forename: Beate M
authors.initials: BM
authors.lastname: Stoeckelhuber
authors.forename: Fritz
authors.initials: F
authors.lastname: Hohagen
authors.forename: Kerstin M
authors.initials: KM
authors.lastname: Oltmanns
authors.forename: Kai G
authors.initials: KG
authors.lastname: Kahl
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schweiger
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000328:Adult; D000367:Age Factors; D000928:Antidepressive Agents / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001883:Borderline Personality Disorder / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D003865:Major Depressive Disorder / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D015850:Interleukin-6 / Q000097:blood; D050152:Intra-Abdominal Fat / Q000502:physiology*; D016014:Linear Models; D050356:Lipid Metabolism; D008279:Magnetic Resonance Imaging; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000928:Antidepressive Agents; D001786:Blood Glucose; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha