title: Prevalence of high-risk human papillomavirus infection and cytologic results in Thailand.
abstract: Cervical cancer is the second most common female cancer with a high mortality rate. The established cause is high-risk types of human papillomavirus (HPV) and a new modality for cervical cancer screening is the combination of cervical cytology with HPV testing. The aim of present study was to identify the prevalence of high-risk HPV infection, and cervical cytological profiles of healthy Thai women. This largest cross-sectional investigation of HPV testing so far with cytology screening in Thailand was conducted between April 2009 and March 2010, covering a total of 14,747 women. The correlation between HPV viral load and cytology was also assessed. The mean age of the study group was 46.4 years (range 20-77 years) and the prevalence of high risk HPV infection was 8.23%. In positive women, negative cytology was observed in 72.9% , and cytology abnormalities in 27.1%, as compared to 1.57% in HPV negative women. The highest prevalence of HPV infection was identified in the youngest age group (≤30 years). The mean viral load was 6.06x105 (range 5,040.13 to 1.05x107) and HPV viral load titers were higher among in women with abnormal cytology.
authors.affiliation: Gynecological Oncology Division, Pathological Division, National Cancer Institute, Bangkok, Thailand. ssanersak@yahoo.com
authors.forename: Sukumarn Sanersak
authors.initials: SS
authors.lastname: Swangvaree
authors.forename: Phon
authors.initials: P
authors.lastname: Kongkaew
authors.forename: Parichat
authors.initials: P
authors.lastname: Rugsuj
authors.forename: Orasri
authors.initials: O
authors.lastname: Saruk
mesh_terms: D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000473:pathology*; D003581:Cytodiagnosis; D004279:DNA, Viral / Q000235:genetics; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D019562:Viral Load; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology / Q000821:virology
chemical_list: D004279:DNA, Viral