title: Neurobehavioral mechanisms of temporal processing deficits in Parkinson's disease.
abstract: BACKGROUND
  Parkinson's disease (PD) disrupts temporal processing, but the neuronal sources of deficits and their response to dopamine (DA) therapy are not understood. Though the striatum and DA transmission are thought to be essential for timekeeping, potential working memory (WM) and executive problems could also disrupt timing.
  
  
  RESULTS
  The present study addressed these issues by testing controls and PD volunteers 'on' and 'off' DA therapy as they underwent fMRI while performing a time-perception task. To distinguish systems associated with abnormalities in temporal and non-temporal processes, we separated brain activity during encoding and decision-making phases of a trial. Whereas both phases involved timekeeping, the encoding and decision phases emphasized WM and executive processes, respectively. The methods enabled exploration of both the amplitude and temporal dynamics of neural activity. First, we found that time-perception deficits were associated with striatal, cortical, and cerebellar dysfunction. Unlike studies of timed movement, our results could not be attributed to traditional roles of the striatum and cerebellum in movement. Second, for the first time we identified temporal and non-temporal sources of impaired time perception. Striatal dysfunction was found during both phases consistent with its role in timekeeping. Activation was also abnormal in a WM network (middle-frontal and parietal cortex, lateral cerebellum) during encoding and a network that modulates executive and memory functions (parahippocampus, posterior cingulate) during decision making. Third, hypoactivation typified neuronal dysfunction in PD, but was sometimes characterized by abnormal temporal dynamics (e.g., lagged, prolonged) that were not due to longer response times. Finally, DA therapy did not alleviate timing deficits.
  
  
  CONCLUSIONS
  Our findings indicate that impaired timing in PD arises from nigrostriatal and mesocortical dysfunction in systems that mediate temporal and non-temporal control-processes. However, time perception impairments were not improved by DA treatment, likely due to inadequate restoration of neuronal activity and perhaps corticostriatal effective-connectivity.
authors.affiliation: Research, Neurology, and Radiology Services, Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America. dharrington@ucsd.edu
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Harrington
authors.forename: Gabriel N
authors.initials: GN
authors.lastname: Castillo
authors.forename: Paul A
authors.initials: PA
authors.lastname: Greenberg
authors.forename: David D
authors.initials: DD
authors.lastname: Song
authors.forename: Stephanie
authors.initials: S
authors.lastname: Lessig
authors.forename: Roland R
authors.initials: RR
authors.lastname: Lee
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Rao
mesh_terms: D000328:Adult; D000368:Aged; D003071:Cognition / Q000502:physiology*; D004298:Dopamine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D011340:Problem Solving / Q000502:physiology; D013647:Task Performance and Analysis; D013998:Time Perception / Q000502:physiology*
chemical_list: D004298:Dopamine