title: Assay of two 10% (w/v) fipronil spot-on formulations against feline infestations with Ctenocephalides felis.
abstract: A new fipronil-based spot-on formulation was evaluated against experimental flea infestations in cats in two studies. In both studies, eight cats served as negative controls (groups 1 and 4); on day 0, eight cats were treated with a 10% w/v fipronil-based spot-on solution (Effipro Spot-on, 0.5ml per cat, groups 2 and 5) and eight cats served as positive controls (Frontline Spot-on, 0.5ml per cat, groups 3 and 6). Each cat was infested on day - 1 with 50 fleas (study 1) and weekly (day 7-day 56) with 100 fleas (study 2). Geometric mean flea counts obtained 48h after the treatment or each re-infestation were reduced by 99.0 and 98.3% in groups 2 and 3, respectively, on day 2, compared to the negative control group. Cats were protected from re-infestations with an efficacy >99% for 58 days in group 5 and for 37 days in group 6.
authors.affiliation: Ecole Nationale Vétérinaire de Toulouse 23, chemin des Capelles, 31076 Toulouse cedex 3, France. mc.cadiergues@envt.fr
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Cadiergues
authors.forename: Stéphane G
authors.initials: SG
authors.lastname: Bonneau
authors.forename: Josephus J
authors.initials: JJ
authors.lastname: Fourier
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D058251:Ctenocephalides / Q000187:drug effects*; D005260:Female; D058267:Flea Infestations / Q000188:drug therapy / Q000662:veterinary*; D007306:Insecticides / Q000627:therapeutic use*; D008297:Male; D011720:Pyrazoles / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D011720:Pyrazoles; C082360:fipronil