title: Prospective multicenter observational study of encapsulating peritoneal sclerosis with neutral dialysis solution--the NEXT-PD study.
abstract: Many observational studies have been conducted on the occurrence of encapsulating peritoneal sclerosis (EPS). However, poorly biocompatible acidic glucose-based dialysis solutions were used in all previous studies. Today, dialysis solutions that are more biocompatible have become widely available. We therefore initiated a new prospective observational study on the occurrence of EPS. The study design is based on that of a previous study conducted in Japan that used solutions high in glucose degradation products (GDPs). Patients undergoing dialysis with a low-GDP dialysis solution, which is considered to show excellent biocompatibility, will be followed for 4 years, and the study will evaluate withdrawal from peritoneal dialysis, incidence of EPS, and factors related to EPS occurrence with the new dialysis solution. This study is expected to clarify the effects of biocompatible dialysis solutions.
authors.affiliation: Tsuchiya General Hospital, Hiroshima, Japan. h-kawanishi@tuschiya-hp.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Kawanishi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakayama
authors.forename: Masanobu
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Kazuho
authors.initials: K
authors.lastname: Honda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Tomo
authors.forename: Kenji
authors.initials: K
authors.lastname: Kasai
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Nakamoto
mesh_terms: D001672:Biocompatible Materials; D005260:Female; D005936:Glucans; D005947:Glucose / Q000032:analysis; D015312:Hemodialysis Solutions / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D000077607:Icodextrin; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D056627:Peritoneal Fibrosis / Q000209:etiology* / Q000517:prevention & control
chemical_list: D001672:Biocompatible Materials; D005936:Glucans; D015312:Hemodialysis Solutions; D000077607:Icodextrin; D005947:Glucose