title: Meningococcal vaccine trials.
abstract: The evaluation of meningococcal vaccines in humans is a challenging task. Issues of safety, and benefit to the individual patient and to the community may raise difficult ethical problems. The inherent variability of human responses, the rarity of clinical disease, age-dependence in the immune response, and the role of carriers complicates the evaluation process.
authors.affiliation: Department of Statistics, The Open University, Milton, Keynes, UK.
authors.forename: P
authors.initials: P
authors.lastname: Farrington
authors.forename: E
authors.initials: E
authors.lastname: Miller