title: Development of vaccines against tuberculosis.
abstract: Development of an effective vaccine against tuberculosis (TB) hinges on an improved understanding of the human immune responses to Mycobacterium tuberculosis. A successful vaccination strategy should be able to stimulate the appropriate arm of the immune system with concomitant generation of the memory cells. In the absence of a perfect strategy, while long term efforts of TB researchers continue to resolve the nature of protective immunity against TB and other related issues, the current approach, dictated by the urgency of a TB vaccine, employs available knowledge and technology to develop new TB vaccines and channel the promising ones to clinical trials. While Indian scientists have contributed in several areas towards the development of a TB vaccine, this review is an attempt to summarize their contributions mainly pertaining to the discovery of new antigens, immune responses elicited by antigens against TB and development of new vaccines and their evaluation in animal models.
authors.affiliation: Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India. aniltyagi@south.du.ac.in
authors.forename: Anil K
authors.initials: AK
authors.lastname: Tyagi
authors.forename: Prachi
authors.initials: P
authors.lastname: Nangpal
authors.forename: Vijaya
authors.initials: V
authors.lastname: Satchidanandam
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D004195:Disease Models, Animal; D015195:Drug Design; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007194:India; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*; D032581:Tuberculosis Vaccines
chemical_list: D000942:Antigens, Bacterial; D000949:Histocompatibility Antigens Class II; D032581:Tuberculosis Vaccines