title: [Effect of three penetration enhancers on corneal permeability of mangiferin in vitro].
abstract: OBJECTIVE
  To investigate the effects of labrasol, solutol HS 15 and transcutol P on the corneal permeability of mangiferin in vitro.
  
  
  METHODS
  The effects of three penetration enhancers on the corneal permeability of mangiferin were investigated in vitro by using isolated rabbit corneas.
  
  
  RESULTS
  The apparent Papp enhancements were increased 1.80, 3.27, 3.41 and 4.76-folds with Lab at 1.0%, 1.5%, 2.0% and 3.0% (P < 0.01), respectively. The apparent Papp increased 1.98 and 3.07-folds with Sol at 0.2% and 0.4% (P < 0.01), respectively, but reduced with 0.010%-0.03% Trans.
  
  
  CONCLUSIONS
  The Papp value of mangiferin is significantly enhanced by 1.0%-3.0% Lab, 0.2% and 0.4% Sol, however the Papp value of mangiferin is reduced by 0.01%-0.03% Trans.
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China. lr_8000@163.com
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Liu
authors.forename: Lexin
authors.initials: L
authors.lastname: Shu
authors.forename: Chengui
authors.initials: C
authors.lastname: Zhang
authors.forename: Boli
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003315:Cornea / Q000187:drug effects* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D005026:Ethylene Glycols / Q000737:chemistry; D005989:Glycerides; D066298:In Vitro Techniques; D009930:Organic Chemicals / Q000737:chemistry; D010539:Permeability; D010936:Plant Extracts / Q000493:pharmacokinetics*; D011092:Polyethylene Glycols / Q000737:chemistry; D011817:Rabbits; D013229:Stearic Acids / Q000737:chemistry; D044004:Xanthones / Q000493:pharmacokinetics*
chemical_list: D004337:Drug Carriers; D005026:Ethylene Glycols; D005989:Glycerides; D009930:Organic Chemicals; D010936:Plant Extracts; D013229:Stearic Acids; D044004:Xanthones; C440220:Labrasol; C013592:mangiferin; D011092:Polyethylene Glycols; C067028:Solutol HS 15; C010111:carbitol