title: Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds.
abstract: In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C-C bonds. Of these compounds, 2-Benzyl-2-[2-phenyl-1-ethenyl]-1,2,3,4-tetrahydro-1-naphthalenol 12 exhibited most promising activity both in vitro and in vivo.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland.
authors.forename: James W
authors.initials: JW
authors.lastname: Barlow
authors.forename: Aengus P
authors.initials: AP
authors.lastname: McHugh
authors.forename: Orla
authors.initials: O
authors.lastname: Woods
authors.forename: John J
authors.initials: JJ
authors.lastname: Walsh
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016718:Arachidonic Acid; D002452:Cell Count; D002470:Cell Survival / Q000187:drug effects; D004427:Ear Diseases / Q000139:chemically induced / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006967:Hypersensitivity / Q000188:drug therapy; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D009284:Naphthols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013237:Stereoisomerism
chemical_list: C559779:1,2,3,4-tetrahydro-1-naphthalenol; D018926:Anti-Allergic Agents; D009284:Naphthols; D016718:Arachidonic Acid