title: Protuboxepins A and B and protubonines A and B from the marine-derived fungus Aspergillus sp. SF-5044.
abstract: Two new oxepin-containing (1 and 2) and two diketopiperazine-type alkaloids (3 and 4) have been isolated from an EtOAc extract of the marine-derived fungus Aspergillus sp. SF-5044. The structures of these metabolites were determined through analysis of NMR and MS data, along with Marfey's method. Compound 1 showed weak growth inhibitory activity against a small panel of cell lines.
authors.affiliation: College of Medical and Life Sciences, Silla University, Busan 617-736, Republic of Korea.
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Lee
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Asami
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Jae-Hyuk
authors.initials: JH
authors.lastname: Jang
authors.forename: Jong Seog
authors.initials: JS
authors.lastname: Ahn
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010082:Oxepins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D054659:Diketopiperazines; D010082:Oxepins; C560175:protubonine A; C560176:protubonine B; C560174:protuboxepin A; C560173:protuboxepin B