title: Possible role of cholinesterase inhibitors on memory consolidation following hypobaric hypoxia of rats.
abstract: High altitude (HA) generates a deleterious effect known as hypobaric hypoxia (HBH). This causes severe physiological and psychological changes such as acute mountain sickness (AMS) and cognitive functions in terms of learning and memory. The present study has evaluated the effect of cholinesterase inhibitors on memory consolidation following HBH. Adult male Sprague Dawley rats (80-90 days old) with an average body weight of 250 ± 25 g were used. Rats were assessed memory consolidation by using Morris water maze (MWM) for 8 days. After assessment of memory consolidation, rats were then exposed to HBH in stimulated chamber for 7 days at 6,100 m. After exposure to HBH, the memory consolidation of rats has been assessed in MWM. The results showed that there was memory consolidation impairment in HBH-exposed rats as compared to normoxic rats in terms of time spent in quaradents, rings, and counters. The rats which have been treated with physostigmine (PHY) and galantamine (GAL) showed better time spent in quaradents, rings, and counters as compared with hypoxic rats. In conclusion, the cholinesterase inhibitors could ameliorate the impairment of memory consolidation following HBH.
authors.affiliation: Neurobiology Division, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Ministry of Defence, Government of India, Delhi, India.
authors.forename: Sangu
authors.initials: S
authors.lastname: Muthuraju
authors.forename: Panchanan
authors.initials: P
authors.lastname: Maiti
authors.forename: Preeti
authors.initials: P
authors.lastname: Solanki
authors.forename: Alpesh Kumar
authors.initials: AK
authors.lastname: Sharma
authors.forename: Soumya
authors.initials: S
authors.lastname: Pati
authors.forename: Shashi Bala
authors.initials: SB
authors.lastname: Singh
authors.forename: Dipti
authors.initials: D
authors.lastname: Prasad
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Ilavazhagan
mesh_terms: D000109:Acetylcholine / Q000819:agonists / Q000502:physiology; D000399:Air Pressure; D000532:Altitude Sickness / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004195:Disease Models, Animal; D005702:Galantamine / Q000494:pharmacology; D002534:Hypoxia, Brain / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D008569:Memory Disorders / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002800:Cholinesterase Inhibitors; D005702:Galantamine; D010830:Physostigmine; D000109:Acetylcholine