title: [Anti-HBV constituents from Euphorbia fischeriana].
abstract: OBJECTIVE
  To investigate the anti-HBV constituents in the roots of Euphorbia fischeriana.
  
  
  METHODS
  The compounds were isolated by various chromatographic methods and identified by spectroscopic analysis. Some compounds were tested for the anti-HBV activity.
  
  
  RESULTS
  Eleven compounds were isolated and identified as tirucalla-5,24-dien-3-ol (1), 24-methyltirucalla-5, 24-dien-3-ol (2), euphol (3), butyrospermol (4), 24-methylenecycloartenol (5), cycloartenol (6), jolkinolid E (7) helioscopinolide A (8), isoscopoletion (9), dephnoretin (10), and 3, 3'-di-O-methylellagic acid 4'-O-beta-D-xylopyranoside (11).
  
  
  CONCLUSIONS
  Compounds 1, 2 and 10 were isolated from the genus Euphorbia for the first time. Compounds 3, 4 and 11 were isolated from this species for the first time. Compounds 1, 8, 9 and 11 showed weak anti-HBsAg and anti-HBeAg activity, while compound 10 showed weak anti-HBsAg activity.
authors.affiliation: School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Yu
authors.forename: Aijun
authors.initials: A
authors.lastname: Hou
mesh_terms: D000998:Antiviral Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D006515:Hepatitis B virus / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal