title: Nonbacterial osteitis in children: data of a German Incidence Surveillance Study.
abstract: OBJECTIVE
  To analyse the incidence, clinical presentation, laboratory and radiological findings, as well as diagnostic approaches and therapeutic procedures in paediatric patients suffering from nonbacterial osteitis.
  
  
  METHODS
  A nationwide incidence survey was conducted from 2006 to 2008 through monthly contacts with all German paediatric and paediatric-orthopaedic hospitals. Children with osteomyelitic bone lesions newly diagnosed as suffering from nonbacterial osteitis were identified. Cases were assessed using a questionnaire to be filled in by the treating physician containing information on time since first symptoms, associated diseases, diagnostic procedures, localization of lesions, complications, laboratory and histological results, and treatment.
  
  
  RESULTS
  Nonbacterial osteitis was newly reported in 148 children. The annual incidence was estimated at 0.4 per 100,000 children. Mean manifestation age was 11.4 years (SD 3.2); 99 children (67%) were girls. Palmoplantar pustulosis was observed in 8 (6%). Unifocal manifestations were seen in 50 (34%) patients. Of all patients with vertebral involvement (15%), 9% suffered from vertebral fractures. Bone biopsies were taken in 79 (53%) patients.
  
  
  CONCLUSIONS
  Nonbacterial osteitis is an auto-inflammatory disorder resulting in at least 60 new paediatric cases/year in Germany. Spinal lesions and complications are frequently observed, even at first diagnosis.
authors.affiliation: Dr. v. Haunersches Kinderspital, Ludwig-Maximilians University, Munich, Germany. annette.jansson@med.uni-muenchen.de
authors.forename: Annette F
authors.initials: AF
authors.lastname: Jansson
authors.forename: Veit
authors.initials: V
authors.lastname: Grote
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000453:epidemiology; D000293:Adolescent; D001842:Bone and Bones / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D010000:Osteitis / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D010019:Osteomyelitis / Q000453:epidemiology