title: Gorham-Stout syndrome of the pelvic girdle treated by radiation therapy: a case report.
abstract: BACKGROUND
  The Gorham-Stout syndrome (GSS) is a rare, benign idiopathic and progressive disorder causing massive osteolysis due to a vascular hyperproliferation replacing the bony structure. Clinical experience concerning the efficacy of radiation therapy (RT) is limited to about 50 of an overall 200 cases reported worldwide.
  
  
  METHODS
  A 24-year-old bedridden woman had histologically proven GSS with destruction of the anterior pelvic girdle and received RT for a total dose of 45.0 Gy applied in 5 weekly fractions of 1.8 Gy. In addition, the patient received intravenously 4 mg zoledronic acid once a month. One year after the combined treatment, complete pain relief occurred, and the patient was able to walk without the use of appliances. Imaging studies revealed no progression of the osteolysis but only minimal signs of remineralization.
  
  
  CONCLUSIONS
  Combined treatment with RT and bisphosphonate administration can prevent the progression of osteolysis in GSS. Total doses of 40-45 Gy are recommended.
authors.affiliation: Strahlenklinik, Klinikum Offenbach, Offenbach am Main, Germany. Reiniheyd@aol.com
authors.forename: Reinhard
authors.initials: R
authors.lastname: Heyd
authors.forename: Daniela
authors.initials: D
authors.lastname: Rabeneck
authors.forename: Oliver
authors.initials: O
authors.lastname: Dörnenburg
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Tselis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zamboglou
mesh_terms: D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004164:Diphosphonates / Q000008:administration & dosage; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D051346:Mobility Limitation; D010015:Osteolysis, Essential / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy*; D010147:Pain Measurement / Q000187:drug effects / Q000528:radiation effects; D010384:Pelvic Bones / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D011880:Radiotherapy Planning, Computer-Assisted; D014057:Tomography, X-Ray Computed; D055815:Young Adult; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid