title: [Expressions of survivin and GRIM-19 in prostate cancer].
abstract: OBJECTIVE
  To investigate the expressions of survivin and GRIM-19 in prostatic cancer tissue and their clinical implications.
  
  
  METHODS
  We detected the expressions of survivin and GRIM-19 in the tissues of normal prostate (NP), benign prostate hyperplasia (BPH) and prostate cancer (PCa) using immunohistochemical staining, RT-PCR and Western blot, and processed the data by SPSS12.
  
  
  RESULTS
  The positive rates of survivin expression were 6.25% , 18.18% and 90.62% in NP, BPH and PCa (P < 0.01), while those of GRIM-19 were 87.50%, 81.82% and 9.37% , respectively (P < 0.01). Semiquantitative RT-PCR and immunohistochemical staining showed that both survivin mRNA and survivin expressions were highly positive in PCa but negative in NP and BPH. Western blot exhibited that the survivin protein was expressed strongly in PCa but weakly in NP and BPH, while the GRIM-19 protein was expressed just contrariwise (P < 0.01).
  
  
  CONCLUSIONS
  The expressions of survivin and GRIM-19 may be closely correlated with the pathogenesis of prostate cancer.
authors.affiliation: Department of Pathophysiology, Beihua University Medical College, Jilin, Jilin 132013, China. liuyanbobeihua@163.com
authors.forename: Yan-bo
authors.initials: YB
authors.lastname: Liu
authors.forename: Wei-gao
authors.initials: WG
authors.lastname: Shen
authors.forename: He
authors.initials: H
authors.lastname: Ge
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Gai
authors.forename: Li-li
authors.initials: LL
authors.lastname: Lu
authors.forename: Xue-jian
authors.initials: XJ
authors.lastname: Zhao
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D008297:Male; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D000077022:Survivin
chemical_list: D051017:Apoptosis Regulatory Proteins; C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin; D009247:NADH, NADPH Oxidoreductases; C439057:NDUFA13 protein, human