title: (99m)Tc-DTPA diuretic renal scintigraphy in dogs with nephroureterolithiasis.
abstract: This study evaluated the results of diuretic renal scintigraphy in dogs with urolithiasis. Eighty-three kidneys with nephroureterolithiasis +/- renal pelvis/ureteral dilation were included in the study. Sixty-three kidneys showed a non-obstructive pattern, with a steep drop or gradual downward slope of renal time-activity curve (TAC). Excretion half-time of radiopharmaceutical (T(1/2)) was 3.99 (2.99 to 7.95) min. Three kidneys showed an obstructive pattern, with continuous rise of the TAC and median T(1/2) of -10.71 (-5.20 to -17.56) min. Fifteen kidneys had non-diagnostic studies characterized by flat TAC. Individual kidney glomerular filtration rate was <0.5 mL/min/kg body weight in most non-diagnostic studies. Diuretic renal scintigraphy appears to be a useful adjunct modality to rule out or confirm ureteral obstruction in dogs. Additional diagnostic procedures may be necessary to achieve a definitive diagnosis in cases of severely impaired renal function.
authors.affiliation: Department of Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, USA. shecht@utk.edu
authors.forename: Silke
authors.initials: S
authors.lastname: Hecht
authors.forename: S Meg
authors.initials: SM
authors.lastname: Lawson
authors.forename: India F
authors.initials: IF
authors.lastname: Lane
authors.forename: Dorothy E
authors.initials: DE
authors.lastname: Sharp
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Daniel
mesh_terms: D000818:Animals; D004232:Diuretics / Q000008:administration & dosage; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000662:veterinary; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D008297:Male; D053040:Nephrolithiasis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D011877:Radionuclide Imaging / Q000379:methods / Q000662:veterinary*; D016284:Technetium Tc 99m Pentetate / Q000008:administration & dosage; D014517:Ureteral Obstruction / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D052878:Urolithiasis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
chemical_list: D004232:Diuretics; D016284:Technetium Tc 99m Pentetate