title: Methods for manipulation of transferrin-binding proteins.
abstract: To obtain iron, a necessary nutrient, meningococci and several other human and veterinary pathogens have iron-acquisition systems, which are expressed in vivo during infection. One target of iron-acquisition systems is transferrin (Tf), which is the major glycoprotein responsible for the transport of iron in the extracellular milieu of vertebrates. Tf-binding proteins A and B (TbpA and TbpB) function as the cell-surface Tf receptor in Neisseria meningitidis (1).
authors.affiliation: Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, AB, Canada.
authors.forename: L M
authors.initials: LM
authors.lastname: Dewinter
authors.forename: A B
authors.initials: AB
authors.lastname: Schryvers