title: [Effect of zeranol on spermary and spermigenesis function of male mice].
abstract: OBJECTIVE
  To study the effects of zeranol on spermiogenesis function of mice and its possible mechanism.
  
  
  METHODS
  40 healthy mature male mice were randomly divided into four groups: negative group and zeranol exposure groups (25, 50, 100 mg/kg). Male mice were respectively administered with zeranol at the doses of 25, 50, and 100 mg/kg for 35 days and killed. The weights of spermary, epididymis and spermatocyst were measured. The sperm counting, motility and the percent of abnormal sperms were observed. Pathological changes of testicle tissue were also observed.
  
  
  RESULTS
  In comparison with control group, the visceral coefficient of spermatocysts and sperm counting of zeranol exposure groups were all decreased ( P < 0.05). Sperm motility were significantly decreased in the median and high exposure groups (P < 0.05). Pathological alterations of testes were also observed. Seminiferous epithelium was reduced in exposure groups, loose and anomalistic organization. Sperm counts were also reduced in the lumina of seminiferous tubules with glair.
  
  
  CONCLUSIONS
  Zeranol have toxicity effect on spermigenesis function of male mice.
authors.affiliation: Shandong Academy of Occupational Health and Occupational Medicine, Jinan 250062, China. zhenling788@yahoo.com.cn
authors.forename: Zhenling
authors.initials: Z
authors.lastname: Zhang
authors.forename: Cunxiang
authors.initials: C
authors.lastname: Bo
authors.forename: Qiming
authors.initials: Q
authors.lastname: Guo
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D004822:Epididymis / Q000166:cytology / Q000187:drug effects; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D008297:Male; D051379:Mice; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects* / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology; D013737:Testis / Q000187:drug effects / Q000503:physiopathology*; D015029:Zeranol / Q000633:toxicity*
chemical_list: D004968:Estrogens, Non-Steroidal; D015029:Zeranol