title: Cladielloides A and B: new eunicellin-type diterpenoids from an Indonesian octocoral Cladiella sp.
abstract: Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.
authors.affiliation: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan. tony_chen72001@yahoo.com.tw
authors.forename: Yung-Husan
authors.initials: YH
authors.lastname: Chen
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Tai
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Ching-Feng
authors.initials: CF
authors.lastname: Weng
authors.forename: Jan-Jung
authors.initials: JJ
authors.lastname: Li
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D007214:Indonesia; D007941:Leukemia P388; D019272:Leukocyte Elastase / Q000378:metabolism; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D004224:Diterpenes; C560832:cladielloide A; C560831:cladielloide B; C476503:eunicellin; D013481:Superoxides; D019272:Leukocyte Elastase