title: The daily rhythm of mice.
abstract: The house mouse Mus musculus represents a valuable tool for the analysis and the understanding of the mammalian circadian oscillator. Forward and reverse genetics allowed the identification of clock components and the verification of their function within the circadian clockwork. In many cases unforeseen links were discovered between a particular circadian regulatory protein and various diseases or syndromes. Thus, this model system is not only perfectly suited to pinpoint the components of the mammalian circadian clock, but also to unravel metabolic, physiological, and pathological processes linked to the circadian timing system.
authors.affiliation: Department of Medicine/Unit of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland. juergenalexandereduard.ripperger@unifr.ch
authors.forename: Jürgen A
authors.initials: JA
authors.lastname: Ripperger
authors.forename: Corinne
authors.initials: C
authors.lastname: Jud
authors.forename: Urs
authors.initials: U
authors.lastname: Albrecht
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D010829:Physiological Phenomena