title: Salmonella-induced tubular networks.
abstract: Salmonella virulence relies on its capacity to replicate inside various cell types in a membrane-bound compartment, the Salmonella-containing vacuole (SCV). A unique feature of Salmonella-infected cells is the presence of tubular structures originating from and connected to the SCV, which often extend throughout the cell cytoplasm. These tubules include the well-studied Salmonella-induced filaments (SIFs), enriched in lysosomal membrane proteins. However, recent studies revealed that the Salmonella-induced tubular network is more extensive than previously thought and includes three types of tubules distinct from SIFs: sorting nexin tubules, Salmonella-induced secretory carrier membrane protein 3 (SCAMP3) tubules and lysosome-associated membrane protein 1 (LAMP1)-negative tubules. In this review, we examine the molecular mechanisms involved in the formation of Salmonella-induced tubular networks and discuss the importance of the tubules for Salmonella virulence and establishment of a Salmonella intracellular replicative niche.
authors.affiliation: Institute of Molecular Biology, Academia Sinica, Academia Rd. 128 Sec. 2, Nankang, Taipei 115, Taiwan, ROC.
authors.forename: Nina
authors.initials: N
authors.lastname: Schroeder
authors.forename: Luís Jaime
authors.initials: LJ
authors.lastname: Mota
authors.forename: Stéphane
authors.initials: S
authors.lastname: Méresse
mesh_terms: D006801:Humans; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D012475:Salmonella / Q000235:genetics / Q000502:physiology*; D012480:Salmonella Infections / Q000378:metabolism* / Q000382:microbiology; D014617:Vacuoles / Q000378:metabolism* / Q000382:microbiology
chemical_list: D011506:Proteins