title: Integrated approach to nitric oxide in animals and plants (mechanism and bioactivity): cell signaling and radicals.
abstract: Nitric oxide was first the object of extensive investigation in animals. It has been designated as the most widespread signaling molecule. An overview is presented with emphasis on cell signaling, mechanism, and physiological activity. Hence, a basis is provided for comparison of NO in plants with a similar approach. Mechanistically, cell signaling, electron transfer, radicals, and antioxidants are involved. A role is played by NO derivatives, such as peroxynitrite, nitroxyl, nitrite, nitrate, and S-nitroso derivatives. Comparison is made with ethylene. The multifaceted, interdisciplinary approach provides novel insight.
authors.affiliation: Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA. pkovacic@sundown.sdsu.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Kovacic
authors.forename: Ratnasamy
authors.initials: R
authors.lastname: Somanathan
mesh_terms: D000818:Animals; D005609:Free Radicals / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D005609:Free Radicals; D009569:Nitric Oxide