title: Acylphloroglucinol and xanthones from Hypericum ellipticum.
abstract: An acylphloroglucinol, elliptophenone A, and two xanthones, elliptoxanthone A and elliptoxanthone B, were isolated from the aerial portions of Hypericum ellipticum together with three known xanthones, 1,3,7-trihydroxy-8-(3-methyl-2-butenyl)-9H-xanthen-9-one, 1,6-dihydroxy-4-methoxy-9H-xanthen-9-one, and 1,4,5-trihydroxy-9H-xanthen-9-one. Their structures were determined by spectroscopic analyses. The acylphloroglucinol and xanthones were evaluated for cytotoxicity using three human colon cancer cell lines cell lines (HT-29, HCT-116 and Caco-2) and a normal human colon cell line (CCD-18Co).
authors.affiliation: Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, PA 17870, USA.
authors.forename: Kylie
authors.initials: K
authors.lastname: Manning
authors.forename: Elyse
authors.initials: E
authors.lastname: Petrunak
authors.forename: Michelle
authors.initials: M
authors.lastname: Lebo
authors.forename: Antonio
authors.initials: A
authors.lastname: González-Sarrías
authors.forename: Navindra P
authors.initials: NP
authors.lastname: Seeram
authors.forename: Geneive E
authors.initials: GE
authors.lastname: Henry
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D044004:Xanthones; C559683:elliptophenone A; C009689:xanthone; D010696:Phloroglucinol