title: [Association between fibroblast growth factor 3 polymorphism and non-syndromic oral clefting].
abstract: OBJECTIVE
  To investigate the association between fibroblast growth factor 3 (FGF3) gene rs4980700 and rs4631909 polymorphism and non-syndromic oral clefting (NSOC).
  
  
  METHODS
  Blood samples from 186 NSOC patients, patients' parents and 200 controls were collected. DNA was extracted and PCR-restriction fragment length polymorphism (PCR-RFLP) was used to identify genotypes of the samples. Case-control analyses and transmission disequilibrium test (TDT) and family based association test (FBAT) analyses were also carried out.
  
  
  RESULTS
  In case-control analysis, there were significant differences in rs4980700 genotype and allele among NSOC patients compared with the control group (P < 0.05) and there were significant differences in rs4631909 genotype and allele among NSOC patients compared with the control group (P < 0.05), but no difference in cleft palate only (P = 0.49). In TDT, the G allele of rs4980700 had an overtransmission (P < 0.05) and the C allele of rs4631909 had an overtransmission (P < 0.05) in NSOC. FBAT analysis also showed a significant association between FGF3 gene rs4980700, rs4631909 polymorphism and NSOC.
  
  
  CONCLUSIONS
  FGF3 gene rs4980700 and rs4631909 polymorphism were associated with NSOC.
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, College of Stomatology, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Sun
authors.forename: Sheng-Sheng
authors.initials: SS
authors.lastname: Guo
authors.forename: Yong-Qing
authors.initials: YQ
authors.lastname: Huang
authors.forename: Min
authors.initials: M
authors.lastname: Ma
authors.forename: Jian
authors.initials: J
authors.lastname: Ma
authors.forename: Hong-Wang
authors.initials: HW
authors.lastname: Ren
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Bing
authors.initials: B
authors.lastname: Shi
mesh_terms: D000483:Alleles; D002971:Cleft Lip; D002972:Cleft Palate; D005260:Female; D051518:Fibroblast Growth Factor 3; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D051518:Fibroblast Growth Factor 3