title: [Prognosis of patients with recurrence after curative resection of advanced gastric cancer].
abstract: OBJECTIVE
  To investigate the clinical features and prognosis of recurrent gastric cancer.
  
  
  METHODS
  Clinical data of 163 patients with recurrent gastric cancer from Jan. 2001 to Jan. 2005 were reviewed. Patients were compared between those with and without symptoms.
  
  
  RESULTS
  Seventy-two patients(44.2%) were symptomatic, while 91(55.8%) were asymptomatic. There were significant differences in lymph node metastasis between the two groups(P<0.05). The median overall survival was significantly longer in asymptomatic patients (19.8 vs. 15.7 months, P<0.05). Post-recurrence survival was also longer in the asymptomatic group (9.5 vs. 4.8 months, P<0.01). The median recurrence-free interval in asymptomatic patients was 10.0 months, which was significantly longer than that in the symptomatic patients (9.2 months, P<0.05). On univariate survival analysis,post-gastrectomy chemotherapy (P<0.05), symptoms of recurrence(P<0.01), TNM staging(P<0.01), recurrence-free interval (P<0.01), and reoperation(P<0.01) were associated with the prognosis. On multivariable analysis, TNM staging(P<0.01), symptoms of recurrence(P<0.01), recurrence-free interval (P<0.05), and reoperation(P<0.05) were independent risk factors.
  
  
  CONCLUSIONS
  Patients with recurrent gastric cancer have poor prognosis. Close monitoring and active follow-up of patients with gastric cancer should be conducted during the first two years after operation. Reoperation may improve survival in patients with recurrent gastric cancer.
authors.affiliation: Department of Gastric Cancer, Cancer Institute and Hospital,Tianjin Medical University, Tianjin 300060, China. tijzhangrp@163.com
authors.forename: Jing-zhu
authors.initials: JZ
authors.lastname: Zhao
authors.forename: Ru-peng
authors.initials: RP
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Fang-xuan
authors.initials: FX
authors.lastname: Li
authors.forename: Xue-jun
authors.initials: XJ
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xue
authors.forename: Han
authors.initials: H
authors.lastname: Liang
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*