title: Zinc-induced dimerization of the amyloid-β metal-binding domain 1-16 is mediated by residues 11-14.
abstract: Analysis of complex formation between amyloid-β fragments using surface plasmon resonance biosensing and electrospray mass spectrometry reveals that region 11-14 mediates zinc-induced dimerization of amyloid-β and may serve as a potential drug target for preventing development and progression of Alzheimer's disease.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov street 32, 119991 Moscow, Russia.
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Kozin
authors.forename: Yuri V
authors.initials: YV
authors.lastname: Mezentsev
authors.forename: Alexandra A
authors.initials: AA
authors.lastname: Kulikova
authors.forename: Maria I
authors.initials: MI
authors.lastname: Indeykina
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Golovin
authors.forename: Alexis S
authors.initials: AS
authors.lastname: Ivanov
authors.forename: Philipp O
authors.initials: PO
authors.lastname: Tsvetkov
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Makarov
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008958:Models, Molecular; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D055503:Protein Multimerization; D013696:Temperature; D015032:Zinc / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D015032:Zinc