title: Phenytoin- and cranial radiotherapy-induced toxic epidermal necrolysis treated with combination therapy: systemic steroid and intravenous immunoglobulin.
abstract: Toxic epidermal necrolysis (TEN) is a rare dermatological disease that causes serious morbidity and mortality. It may be caused by antibiotics, anticonvulsants, nonsteroidal anti-inflammatory agents, allopurinol, infections, autoimmune diseases, and radiotherapy. A 49-year-old man was admitted to our hospital because of skin changes. Prophylactic phenytoin was administered, and cranial radiotherapy was planned for brain metastases. During these treatments, erythematous lesions and blisters were observed on his scalp, face, neck, the front and back of his body, and his arms. Detachment of the skin, especially on the back, was also observed. TEN was diagnosed, and phenytoin was discontinued. Methylprednisolone 80 mg/day IV and intravenous immunoglobulin 1 g/kg/day were applied for treatment. After 10 days, skin recovery and re-epithelialization were established, temperature decreased, and mucosal hemorrhage ceased. The patient was discharged after 2 weeks.
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey. evrenfidan@yahoo.com
authors.forename: E
authors.initials: E
authors.lastname: Fidan
authors.forename: M
authors.initials: M
authors.lastname: Fidan
authors.forename: F
authors.initials: F
authors.lastname: Ozdemir
authors.forename: H
authors.initials: H
authors.lastname: Kavgaci
authors.forename: F
authors.initials: F
authors.lastname: Aydin
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000628:therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000150:complications / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use; D010672:Phenytoin / Q000009:adverse effects*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D016166:Free Radical Scavengers; D016756:Immunoglobulins, Intravenous; D010672:Phenytoin; D010431:Pentoxifylline; D008775:Methylprednisolone