title: Direct enantioselective aldol-Tishchenko reaction catalyzed by chiral lithium diphenylbinaphtholate.
abstract: Chiral lithium diphenylbinaphtholate is an effective catalyst for the enantioselective aldol-Tishchenko reaction, affording 1,3-diol derivatives with three contiguous chiral centers and high stereoselectivities. Successive aldol-aldol-Tishchenko reactions gave a triol derivative with five consecutive chiral centers. The present reaction was applicable to highly enantioselective Evans-Tishchenko reduction.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ichibakase
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakajima
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D018020:Lithium Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D018020:Lithium Compounds; D009284:Naphthols; C116609:3-hydroxybutanal