title: Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients.
abstract: Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200 cells/μL while individuals with CD4 <200 cells/μL showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients.
authors.affiliation: Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Largo F. Vito 1, 00168 Rome, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fabbiani
authors.forename: Simona
authors.initials: S
authors.lastname: Di Giambenedetto
authors.forename: Michela
authors.initials: M
authors.lastname: Sali
authors.forename: Salvatore
authors.initials: S
authors.lastname: Farina
authors.forename: Paola
authors.initials: P
authors.lastname: Sansonetti
authors.forename: Enrica
authors.initials: E
authors.lastname: Tamburrini
authors.forename: Lorenzo Zileri
authors.initials: LZ
authors.lastname: Dal Verme
authors.forename: Giovanni
authors.initials: G
authors.lastname: Delogu
authors.forename: Andrea
authors.initials: A
authors.lastname: De Luca
authors.forename: David
authors.initials: D
authors.lastname: Kelvin
authors.forename: Roberto
authors.initials: R
authors.lastname: Cauda
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fadda
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D018791:CD4 Lymphocyte Count; D005260:Female; D006678:HIV / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011136:Polysorbates / Q000494:pharmacology; D013185:Squalene / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines; C089950:MF59 oil emulsion; D011136:Polysorbates; C558220:focetria; C483468:hemagglutinin, human influenza A virus; D013185:Squalene