title: Association between polymorphism of SDF1 (CXCL12) gene and HIV-1 susceptibility: a meta-analysis.
abstract: Studies on the association between SDF1 genotype and HIV-1 susceptibility have generated inconclusive results. Therefore, we conducted a meta-analysis to summarize the findings of different studies. Articles reporting SDF1 gene polymorphisms among HIV-1 infected patients and controls were searched from PubMed up to June 2010. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the association of SDF1 genotype with HIV-1 susceptibility. As a result, 13 studies with 2421 cases and 3283 controls were included in the meta-analysis. Compared with the wild-type SDF1 homozygotes, the pooled OR for SDF1 heterozygotes and SDF1-3'A homozygotes were 1.07 (95% CI, 0.79-1.45), 1.38 (95% CI, 0.71-2.69) among exposed uninfected controls and 0.89 (95% CI, 0.75-1.07), 1.15 (95% CI, 0.80-1.63) among healthy controls. In conclusion, no statistically significant association between SDF1 genotype and HIV-1 susceptibility was detected in any models. Our data suggested that SDF1 genotype might have limited effect on HIV-1 susceptibility.
authors.affiliation: The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, China.
authors.forename: Sijie
authors.initials: S
authors.lastname: Liu
authors.forename: Huanzhang
authors.initials: H
authors.lastname: Zhu
mesh_terms: D054377:Chemokine CXCL12 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12