title: Histological subclassification of cirrhosis using the Laennec fibrosis scoring system correlates with clinical stage and grade of portal hypertension.
abstract: OBJECTIVE
  Further histological subclassification of cirrhosis may be useful because of heterogeneity of severity within cirrhosis. We aimed to determine the relationship between histological subclassification and clinical stage of cirrhosis as well as grade of portal hypertension.
  
  
  METHODS
  One hundred-twenty-three biopsy-proven cirrhosis patients, whose clinical stage of cirrhosis and hepatic venous pressure gradient (HVPG) could be estimated, were included in this prospective study. Histology of cirrhosis was blindly subclassified using the Laennec fibrosis scoring system semi-quantitatively without knowledge of the clinical stage or the HVPG results. The Laennec system subclassifies cirrhosis as mild - thin septa, moderate - at least two broad septa, and severe - at least one very broad septum or many minute nodules. Clinical stages were determined by the presence or absence of varices, ascites, and variceal hemorrhage. Biological and laboratory data were also collected.
  
  
  RESULTS
  Alcohol intake was the most common cause of cirrhosis in this cohort (87, 70.7%). Histology of cirrhosis subclassified using the Laennec scoring system significantly correlated with both the clinical stage of cirrhosis (p < 0.001) and HVPG (mild: 8.1 ± 2.6 mm Hg, moderate: 12.4 ± 3.3mm Hg, severe: 16.3 ± 4.0 mm Hg, p < 0.001). With higher grades of histological subclassification of cirrhosis, increased frequency in both severe portal hypertension (HVPG ≥ 12 mm Hg) and episodes of variceal hemorrhage were observed (p < 0.001).
  
  
  CONCLUSIONS
  Histological subclassification of cirrhosis by the Laennec fibrosis scoring system is tightly correlated with both the clinical stage of cirrhosis and grade of portal hypertension. This suggests that cirrhosis should be subclassified into different stages according to its histological severity.
authors.affiliation: Department of Internal Medicine, Yonsei University, Wonju College of Medicine, South Korea.
authors.forename: Moon Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Mee Yon
authors.initials: MY
authors.lastname: Cho
authors.forename: Soon Koo
authors.initials: SK
authors.lastname: Baik
authors.forename: Hong Jun
authors.initials: HJ
authors.lastname: Park
authors.forename: Hyo Keun
authors.initials: HK
authors.lastname: Jeon
authors.forename: Chong Kun
authors.initials: CK
authors.lastname: Im
authors.forename: Chan Sik
authors.initials: CS
authors.lastname: Won
authors.forename: Jae Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Sang Ok
authors.initials: SO
authors.lastname: Kwon
authors.forename: Min Seob
authors.initials: MS
authors.lastname: Eom
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Cha
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Kim
authors.forename: Sei Jin
authors.initials: SJ
authors.lastname: Chang
authors.forename: Samuel S
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058625:End Stage Liver Disease / Q000473:pathology; D004932:Esophageal and Gastric Varices / Q000150:complications* / Q000209:etiology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000145:classification* / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D017082:Portal Pressure; D011446:Prospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric