title: Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines.
abstract: An amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities.
authors.affiliation: Department of Chemistry, 3 Science Drive 3, National University of Singapore (NUS), 117543 Singapore, Singapore.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Choon Wee
authors.initials: CW
authors.lastname: Kee
authors.forename: Richmond
authors.initials: R
authors.lastname: Lee
authors.forename: Xiao
authors.initials: X
authors.lastname: Fu
authors.forename: Julian Ying-Teck
authors.initials: JY
authors.lastname: Soh
authors.forename: Esther Mun Foong
authors.initials: EM
authors.lastname: Loh
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Huang
authors.forename: Choon-Hong
authors.initials: CH
authors.lastname: Tan
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D019791:Guanidine / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001388:Aziridines; D019791:Guanidine