title: Role of the CCR5/Δ32CCR5 polymorphism in biopsy-proven giant cell arteritis.
abstract: To further explore the potential role of chemokines in giant cell arteritis (GCA), we have studied whether the CCR5/Δ32CCR5 polymorphism is implicated in the susceptibility to the disease and its specific features. A total of 352 Spanish patients with biopsy-proven GCA and 479 matched controls were assessed. DNA was obtained from peripheral blood. Samples were genotyped by PCR with specific primers spanning the 32-bp deletion region. No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (6.1%) and controls (6.8%) was observed (p = 0.58). This was also the case when the CCR5 /Δ32CCR5 genotype distribution was assessed (p = 0.49). The Δ32CCR5 allele frequency did not differ between patients with or without specific manifestations of the disease, such as polymyalgia rheumatica, visual ischemic manifestations, or irreversible occlusive disease. Hence, our results do not support a potential influence of Δ32CCR5 in the susceptibility to or clinical spectrum of GCA.
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain.
authors.forename: F David
authors.initials: FD
authors.lastname: Carmona
authors.forename: Luis
authors.initials: L
authors.lastname: Rodríguez-Rodríguez
authors.forename: Santos
authors.initials: S
authors.lastname: Castañeda
authors.forename: José A
authors.initials: JA
authors.lastname: Miranda-Filloy
authors.forename: Inmaculada C
authors.initials: IC
authors.lastname: Morado
authors.forename: Javier
authors.initials: J
authors.lastname: Narváez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Marí-Alfonso
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Unzurrunzaga
authors.forename: Raquel
authors.initials: R
authors.lastname: Ríos-Fernández
authors.forename: Ricardo
authors.initials: R
authors.lastname: Blanco
authors.forename: Eugenio
authors.initials: E
authors.lastname: de Miguel
authors.forename: Javier
authors.initials: J
authors.lastname: Martín
authors.forename: Miguel A
authors.initials: MA
authors.lastname: González-Gay
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002561:Cerebrovascular Disorders; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D013700:Giant Cell Arteritis / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011111:Polymyalgia Rheumatica; D019713:Receptors, CCR5 / Q000235:genetics / Q000378:metabolism*; D017384:Sequence Deletion / Q000235:genetics; D013030:Spain; D013699:Temporal Arteries / Q000473:pathology
chemical_list: D019713:Receptors, CCR5