title: Nonsurgical interventions for Peyronie disease: 2011 update.
abstract: Peyronie disease (PD) arises from the deposition of collagen and fibrin  that creates a plaque in the tunica albuginea of the penis. The resulting  induration and curvature of the penis leads to sexual dysfunction in many men.  Despite the prevalence of the disease and natural history studies that suggest  progression, men might not seek therapeutic intervention due to a lack of  general knowledge about the disease, its pathophysiology, and treatments aimed  at ameliorating its symptoms. Medical therapy using oral, topical, or  intralesionally delivered drug is pursued in all but the most severe cases.  This review of the literature in the last 4 years attempts to identify new  trials of therapies and treatment modalities aimed at altering the PD process.  Specifically, we will address clinical trials evaluating oral  pharmacotherapies; topical, intralesional, and shockwave therapies; and penile  traction devices. We will discuss the level of evidence and support for each  of the new clinical trials.
authors.affiliation: James Buchanan Brady Urological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Schaeffer
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Burnett
mesh_terms: D006801:Humans; D008297:Male; D010411:Penile Induration / Q000628:therapy*