title: Chemical fingerprinting and quantitative analysis of a Panax notoginseng preparation using HPLC-UV and HPLC-MS.
abstract: BACKGROUND
  Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular diseases in China. This study develops a simple and global quality evaluation method for the quality control of XST.
  
  
  METHODS
  High performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to identify and quantify the chromatographic fingerprints of the XST injection. Characteristic common peaks were identified using HPLC with photo diode array detection/electrospray ionization tandem mass spectrometry (HPLC-PDA/ESI-MSn).
  
  
  RESULTS
  Representative fingerprints from ten batches of samples showed 27 'common saponins' all of which were identified and quantified using ten reference saponins.
  
  
  CONCLUSIONS
  Chemical fingerprinting and quantitative analysis identified most of the common saponins for the quality control of P. notoginseng products such as the XST injection.
authors.affiliation: Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China. fanxh@zju.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Yao
authors.forename: Peiying
authors.initials: P
authors.lastname: Shi
authors.forename: Qing
authors.initials: Q
authors.lastname: Shao
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Fan