title: Cellular reprogramming: chromatin puts on the brake.
abstract: Directed reprogramming of differentiated cells allows the generation of specific cell types for therapeutics and can provide unexpected insights into development. A recent study demonstrates that efficient reprogramming of Caenorhabditis elegans germ cells into neurons can be achieved by knocking down a histone chaperone gene and ectopic expression of a terminal selector transcription factor.
authors.affiliation: Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA. sengupta@brandeis.edu
authors.forename: Piali
authors.initials: P
authors.lastname: Sengupta
authors.forename: Tim
authors.initials: T
authors.lastname: Schedl
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology*; D002454:Cell Differentiation; D002843:Chromatin / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D014157:Transcription Factors
chemical_list: D002843:Chromatin; D014157:Transcription Factors