title: N,N'-methyleno-didemnin A from the ascidian Trididemnum solidum. Complete NMR assignments and confirmation of the imidazolidinone ring by strategic analysis of 1J(CH).
abstract: The complete NMR assignments of N,N'-methyleno-didemnin A from Trididemnum solidum Van Name 1902 are reported along with a strategic analysis of (1)J(CH) coupling constants that confirm the presence of the imidazolidinone ring.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive MC0358, La Jolla, California 92093-0358, USA. tmolinski@ucsd.edu
authors.forename: Tadeusz F
authors.initials: TF
authors.lastname: Molinski
authors.forename: Jaeyoung
authors.initials: J
authors.lastname: Ko
authors.forename: Kirk A
authors.initials: KA
authors.lastname: Reynolds
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Lievens
authors.forename: Katrina R
authors.initials: KR
authors.lastname: Skarda
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D017691:Caribbean Region; D047630:Depsipeptides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides; C559171:N,N'-methyleno-didemnin A; C030051:didemnins