title: Low HDL-cholesterol among normal weight, normoglycemic offspring of individuals with type 2 diabetes mellitus.
abstract: OBJECTIVE
  Offspring of type 2 diabetics have an increased risk of dyslipidemia, glucose intolerance and obesity. The aim of this study was to assess the lipid levels in the offspring of diabetics with normal glucose tolerance and normal body weight.
  
  
  METHODS
  Normal weight offspring of patients with type 2 diabetes mellitus (DM) who had normal glucose tolerance, and healthy gender matched controls of comparable age without a family history of diabetes mellitus, were the subjects of this study. Lipid profiles were determined in cases and controls.
  
  
  RESULTS
  The study included 114 subjects (64 males and 50 females) in each group, aged (mean ± SD) 24.0 ± 7.9 in cases and 24.1 ± 8.0 years in controls. The body mass index (BMI) was 20.8 ± 3.0 and 20.2 ± 3.1 kg/m2 in cases and controls, respectively. Serum total cholesterol, triglycerides, plasma glucose, fasting insulin, C-peptide and proinsulin levels were comparable in cases and controls. Serum high density lipoprotein (HDL) cholesterol was lower (p <0.001), whilst the serum triglyceride/HDL ratio, low density lipoprotein (LDL) cholesterol and area under the curve for insulin and proinsulin during an oral glucose tolerance test were higher in cases compared to controls. HDL cholesterol showed no significant correlation with plasma glucose, insulin or proinsulin.
  
  
  CONCLUSIONS
  Plasma HDL cholesterol is low among normal weight, normoglycemic offspring of subjects with type 2 diabetes mellitus. The implications of this finding are not apparent.
authors.affiliation: Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India. aca433@yahoo.com
authors.forename: Edavan P
authors.initials: EP
authors.lastname: Praveen
authors.forename: Bindu
authors.initials: B
authors.lastname: Kulshreshtha
authors.forename: Madan L
authors.initials: ML
authors.lastname: Khurana
authors.forename: Jayaprakash
authors.initials: J
authors.lastname: Sahoo
authors.forename: Nandita
authors.initials: N
authors.lastname: Gupta
authors.forename: Guresh
authors.initials: G
authors.lastname: Kumar
authors.forename: Ariachery
authors.initials: A
authors.lastname: Ammini
authors.forename: Rajech
authors.initials: R
authors.lastname: Knadgawat
mesh_terms: D000293:Adolescent; D000328:Adult; D032721:Adult Children; D001786:Blood Glucose / Q000032:analysis* / Q000502:physiology; D016022:Case-Control Studies; D002648:Child; D016241:Child of Impaired Parents / Q000706:statistics & numerical data; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000032:analysis / Q000097:blood*; D003924:Diabetes Mellitus, Type 2; D005192:Family Health; D005260:Female; D006801:Humans; D056865:Ideal Body Weight / Q000502:physiology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL