title: S-nitrosocysteine-decorated PbS QDs/TiO2 nanotubes for enhanced production of singlet oxygen.
abstract: Nitric oxide (NO) is an endogenous diatomic molecule important in regulation of numerous physiological functions. The photorelease of NO in a controlled manner can potentially be used in photodynamic therapy (PDT). We present here a method to combine S-nitrosocysteine with TiO(2) nanotube-doped PbS quantum dots (PbS QDs) as a nitric oxide-releasing vehicle to promote production of singlet oxygen. The PbS QDs with a diameter ∼3.6 nm (PbS/TNTs) were attached to the TiO(2) nanotube by using a thiolactic acid linker. S-nitrosocysteine-decorated PbS/TiO(2) nanotubes were prepared by dipping PbS/TNTs in a cysteine solution followed by nitrosylation. The results suggest that this hybrid nanomaterial is capable of photoreleasing nitric oxide and producing singlet oxygen using near-IR light.
authors.affiliation: Department of Chemistry and the Alan G. MacDiarmid NanoTech Institute, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080-3021, United States.
authors.forename: Chalita
authors.initials: C
authors.lastname: Ratanatawanate
authors.forename: Amy
authors.initials: A
authors.lastname: Chyao
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Balkus
mesh_terms: D002384:Catalysis; D003545:Cysteine / Q000031:analogs & derivatives* / Q000737:chemistry; D007854:Lead / Q000737:chemistry*; D008027:Light; D043942:Nanotubes / Q000737:chemistry*; D009569:Nitric Oxide / Q000378:metabolism*; D010778:Photochemotherapy / Q000379:methods*; D045663:Quantum Dots; D026403:S-Nitrosothiols / Q000737:chemistry*; D026082:Singlet Oxygen / Q000378:metabolism*; D013440:Sulfides / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D026403:S-Nitrosothiols; D013440:Sulfides; C009495:titanium dioxide; D026082:Singlet Oxygen; C018391:lead sulfide; D007854:Lead; D009569:Nitric Oxide; C021315:S-nitrosocysteine; D014025:Titanium; D003545:Cysteine