title: Severe aortic insufficiency due to a huge leaflet perforation in Libman-Sacks syndrome: report of a case.
abstract: A 40-year-old woman who was diagnosed to have systemic lupus erythematosus developed complications of cerebral infarction and alveolar hemorrhage. Close examination revealed severe aortic insufficiency, and she was diagnosed with Libman-Sacks syndrome. Due to progressive dilatation of the left ventricle and her easily fatigued state, surgery was performed. On pathological examination, holes of 4-mm and 5-mm diameter were detected in the left coronary and noncoronary cusps of the aortic valve, respectively. The morphology of the valve lesions showed a characteristic shape of such huge holes.
authors.affiliation: Department of General and Cardiothoracic Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Yashiki
authors.forename: Shojiro
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Hideki
authors.initials: H
authors.lastname: Moriyama
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kato
authors.forename: Shintaro
authors.initials: S
authors.lastname: Takago
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tanaka
authors.forename: Ko
authors.initials: K
authors.lastname: Yoshizumi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohtake
authors.forename: Go
authors.initials: G
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D001021:Aortic Valve; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis; D012422:Rupture, Spontaneous; D012720:Severity of Illness Index; D013577:Syndrome; D014057:Tomography, X-Ray Computed