title: Adipose-derived stem cells: current findings and future perspectives.
abstract: Adipose tissue is an abundant source of mesenchymal stem cells, which have shown promise in the field of regenerative medicine. Furthermore, these cells can be readily harvested in large numbers with low donor-site morbidity. During the past decade, numerous studies have provided preclinical data on the safety and efficacy of adipose-derived stem cells, supporting the use of these cells in future clinical applications. Various clinical trials have shown the regenerative capability of adipose-derived stem cells in subspecialties of medical fields such as plastic surgery, orthopedic surgery, oral and maxillofacial surgery, and cardiac surgery. In addition, a great deal of knowledge concerning the harvesting, characterization, and culture of adipose-derived stem cells has been reported. This review will summarize data from in vitro studies, pre-clinical animal models, and recent clinical trials concerning the use of adipose-derived stem cells in regenerative medicine.
authors.affiliation: Department of Dentistry and Oral Surgery, Self Defense Force Hospital, Yokosuka, Japan.
authors.forename: Morikuni
authors.initials: M
authors.lastname: Tobita
authors.forename: Hakan
authors.initials: H
authors.lastname: Orbay
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizuno
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D002986:Clinical Trials as Topic; D048091:Guided Tissue Regeneration; D006801:Humans; D009369:Neoplasms / Q000473:pathology / Q000628:therapy; D013234:Stem Cells / Q000166:cytology*; D014945:Wound Healing