title: In situ detection of warfarin using time-correlated single-photon counting.
abstract: Here we report on a novel method for the direct in situ measurement of specific isomeric forms of the anticoagulant warfarin using time correlated single-photon counting (TCSPC) spectroscopy in conjunction with synthetic Sudlow I binding site receptors. The method is highly robust over the clinically significant concentration range, and demonstrates the potential of the binding site mimics in conjunction with the spectroscopic strategy employed here for the determination of this important pharmaceutical in clinical or even environmental samples.
authors.affiliation: Bioorganic and Biophysical Chemistry Laboratory, School of Natural Sciences, Linnaeus University, SE-391 82 Kalmar, Sweden.
authors.forename: Annika M
authors.initials: AM
authors.lastname: Rosengren
authors.forename: Björn C G
authors.initials: BC
authors.lastname: Karlsson
authors.forename: Inga
authors.initials: I
authors.lastname: Näslund
authors.forename: Per Ola
authors.initials: PO
authors.lastname: Andersson
authors.forename: Ian A
authors.initials: IA
authors.lastname: Nicholls
mesh_terms: D000925:Anticoagulants / Q000032:analysis* / Q000737:chemistry; D007536:Isomerism; D054802:Molecular Imprinting; D017785:Photons; D013057:Spectrum Analysis / Q000379:methods; D013997:Time Factors; D014859:Warfarin / Q000032:analysis* / Q000737:chemistry
chemical_list: D000925:Anticoagulants; D014859:Warfarin