title: High precision particle mass sensing using microchannel resonators in the second vibration mode.
abstract: An intrinsic uncertainty in particle mass sensing with the suspended microchannel resonator results from variation in a particle's position near the free end of the resonator. To circumvent this error we employ the second flexural bending mode. This mode exhibits additional frequency peaks while particles pass over the antinode, a point where the frequency shift is insensitive to the lateral position of the particle. We measure polystyrene beads with the first and second modes and confirm that the second mode sensing provides a narrower mass histogram. For 3 μm diameter beads, second mode sensing at the antinode improves the coefficient of variation in buoyant mass from 1.76% to 1.05% for population measurements and from 1.40% to 0.53% for a single trapped particle.
authors.affiliation: Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Jungchul
authors.initials: J
authors.lastname: Lee
authors.forename: Andrea K
authors.initials: AK
authors.lastname: Bryan
authors.forename: Scott R
authors.initials: SR
authors.lastname: Manalis
mesh_terms: D008863:Microspheres; D055616:Microtechnology / Q000295:instrumentation* / Q000379:methods*; D011137:Polystyrenes / Q000737:chemistry; D014732:Vibration
chemical_list: D011137:Polystyrenes