title: [Serum metabolome analysis reveals effect of panax notoginosides on ischemic rat after acute myocardial infarction].
abstract: OBJECTIVE
  The effect of panax notoginosides on ischemic rat after acute myocardial infarction by coronary artery ligation was preliminarily investigated using metabonomics approach.
  
  
  METHODS
  GC-MS based metabonomics approach was applied to analyse the serum metabolome of normal group, model group and treatment group of rats. Furthermore, PCA and PIS-DA was used to identify the differentially expressed metabolites among the three groups.
  
  
  RESULTS
  A good fit and prediction results using metabolome data was obtained by PCA and PL-DA. Moreover, 10 metabolites were selected as potential biomarkers for efficacy evaluation of panax notoginosides by t-test and variable importance in the projection.
  
  
  CONCLUSIONS
  Metabonomics provides a whole-organism biological description of pathological or physiological state, and likely can be used as a new approach for efficacy evaluation of traditional Chinese medicine.
authors.affiliation: Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Shao
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Fan
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D055442:Metabolome; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000378:metabolism; D005894:Panax / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044967:Serum / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal