title: Extracellular nucleosides and nucleotides regulate liver functions via a complex system of membrane proteins.
abstract: Nucleosides and nucleotides are now considered as extracellular signalling molecules, like neurotransmitters and hormones. Hepatic cells, amongst other cells, ubiquitously express specific transmembrane receptors that transduce the physiological signals induced by extracellular nucleosides and nucleotides, as well as various cell surface enzymes that regulate the levels of these mediators in the extracellular medium. Here, we cover various aspects of the signalling pathways initiated by extracellular nucleosides and nucleotides in the liver, and discuss their overall impact on hepatic physiology.
authors.affiliation: Centre de recherche en rhumatologie et immunologie, CHU de Québec, QC, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Fausther
authors.forename: Jean
authors.initials: J
authors.lastname: Sévigny
mesh_terms: D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D045604:Extracellular Fluid / Q000502:physiology; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D009705:Nucleosides / Q000502:physiology*; D009711:Nucleotides / Q000502:physiology*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011755:Pyrophosphatases / Q000378:metabolism; D011983:Receptors, Purinergic / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D008565:Membrane Proteins; D009705:Nucleosides; D009711:Nucleotides; D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate; D010744:Phosphoric Monoester Hydrolases; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases