title: New norditerpenoid alkaloids from Scutellaria barbata with cytotoxic activities.
abstract: Two new norditerpenoid alkaloids, named scutebarbatines M-N (1 and 2), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were established on the basis of detailed spectral analyses. In vitro, two new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma and HT29 colorectal carcinoma cells), and gave IC₅₀ values in the range of 3.5-6.3 µM.
authors.affiliation: School of Pharmaceutical Science, Yantai University, Yantai 264005, P.R. China. daishengjun_9@hotmail.com
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Dai
authors.forename: Wei-Bing
authors.initials: WB
authors.lastname: Peng
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: De-Wu
authors.initials: DW
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031363:Scutellaria / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic