title: [Study on pharmacokinetics and biodistribution of pur derivative nanopaticles in mice].
abstract: OBJECTIVE
  To study the pharmacokinetics and biodistribution of pur derivative nanopaticles 4ac in mice.
  
  
  METHODS
  After intravenous administration of 15 mg x kg(-1) of pur derivative 4ac, the plasma and tissue concentration was detected by HPLC. The pharmacokinetics parameters were calculated by the method of 3p97.
  
  
  RESULTS
  The concentration time curves were conformed to two compartment model. The Re of 4ac nanopaticles was 21.18 times higher than suspension.
  
  
  CONCLUSIONS
  Our present study demonstrates that, compared to nanopaticles and suspension, nanopaticles significantly alter the pharmacokinetics in plasma and tissues targeting. Biodistribution of pur derivative 4ac nanopaticles in heart of mice was better than 4ac suspension. It will become a new drug for cardiovascular disease therapy.
authors.affiliation: Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China. winter180@163.com
authors.forename: Dongyan
authors.initials: D
authors.lastname: Guo
authors.forename: Dajian
authors.initials: D
authors.lastname: Yang
authors.forename: Shilin
authors.initials: S
authors.lastname: Chen
mesh_terms: D000818:Animals; D005260:Female; D007529:Isoflavones / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000493:pharmacokinetics*; D029908:Pueraria / Q000737:chemistry*; D011897:Random Allocation; D014018:Tissue Distribution
chemical_list: D007529:Isoflavones; D010936:Plant Extracts; C033607:puerarin