title: In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.
abstract: The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.
authors.affiliation: Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2, Ireland.
authors.forename: Stephane
authors.initials: S
authors.lastname: Desgranges
authors.forename: Florie
authors.initials: F
authors.lastname: Le Prieult
authors.forename: Alan
authors.initials: A
authors.lastname: Daly
authors.forename: Jennifer
authors.initials: J
authors.lastname: Lydon
authors.forename: Marian
authors.initials: M
authors.lastname: Brennan
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Rai
authors.forename: Anusha P
authors.initials: AP
authors.lastname: Subasinghage
authors.forename: Chandralal M
authors.initials: CM
authors.lastname: Hewage
authors.forename: Sally-Ann
authors.initials: SA
authors.lastname: Cryan
authors.forename: Catherine
authors.initials: C
authors.lastname: Greene
authors.forename: Noel G
authors.initials: NG
authors.lastname: McElvaney
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Smyth
authors.forename: Deirdre
authors.initials: D
authors.lastname: Fitzgerald-Hughes
authors.forename: Hilary
authors.initials: H
authors.lastname: Humphreys
authors.forename: Marc
authors.initials: M
authors.lastname: Devocelle
mesh_terms: D003550:Cystic Fibrosis / Q000382:microbiology*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D019272:Leukocyte Elastase / Q000235:genetics / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D010455:Peptides; D019272:Leukocyte Elastase