title: Tumor regression in vivo by photothermal therapy based on gold-nanorod-loaded, functional nanocarriers.
abstract: We developed a very effective hyperthermia system for successful photothermal cancer therapy. Instead of applying individual gold nanorods (GNRs) that can absorb NIR light, GNRs were loaded into functional nanocarriers that could provide stable storage of GNRs and selective delivery to a target tumor site. The functional nanocarriers (chitosan-conjugated, Pluronic-based nanocarriers) were prepared by chemically cross-linking Pluronic F 68 with chitosan conjugation to form a flexible, soft, and excellent reservoir for biomacromolecules as well as tumor targeting. In vivo characteristics of the nanocarriers including a long circulation time, a good tumor accumulation, and low liver uptake were previously characterized by us. When GNRs were delivered by using these nanocarriers, much enhanced in vitro cellular uptake and a photothermal effect were observed for a cancer cell line. More importantly, an intravenous injection of this system followed by NIR laser irradiation to the tumor site resulted in a very efficient thermolysis in vivo. Thus, apparently complete tumor resorption was achieved without damage to the surrounding tissue, suggesting a promising candidate for clinical phototherapeutic applications.
authors.affiliation: School of Materials Science and Engineering and Department of Nanobio Materials and Electronics, Advanced Photonics Research Institute, Gwangju, Korea.
authors.forename: Won Il
authors.initials: WI
authors.lastname: Choi
authors.forename: Ja-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Chul
authors.initials: C
authors.lastname: Kang
authors.forename: Clare C
authors.initials: CC
authors.lastname: Byeon
authors.forename: Young Ha
authors.initials: YH
authors.lastname: Kim
authors.forename: Giyoong
authors.initials: G
authors.lastname: Tae
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006046:Gold / Q000627:therapeutic use*; D006979:Hyperthermia, Induced / Q000379:methods*; D051379:Mice; D008819:Mice, Nude; D053769:Nanocapsules / Q000737:chemistry / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D053769:Nanocapsules; D006046:Gold