title: Parvovirus B19 infection in pregnancy: new insights and management.
abstract: In this article, we review the virology, pathology, epidemiology and clinical spectrum of intrauterine human parvovirus B19 (B19V) infection, including intrauterine fetal death, non-immune hydrops fetalis, thrombocytopenia and neurological manifestations such as pediatric stroke and perivascular calcifications. In addition, we discuss the new insights into the neurodevelopmental outcome of intrauterine B19V infection. Current diagnosis and management of B19V infection is summarized, including a diagnostic and follow-up flowchart for practical clinical use.
authors.affiliation: Department of Pediatrics, HAGA Hospital, Juliana's Childrens Hospital, The Hague, The Netherlands. d.oepkes@lumc.nl
authors.forename: E P
authors.initials: EP
authors.lastname: de Jong
authors.forename: F J
authors.initials: FJ
authors.lastname: Walther
authors.forename: A C M
authors.initials: AC
authors.lastname: Kroes
authors.forename: D
authors.initials: D
authors.lastname: Oepkes
mesh_terms: D000328:Adult; D001805:Blood Transfusion, Intrauterine; D016731:Erythema Infectiosum / Q000453:epidemiology / Q000473:pathology / Q000628:therapy / Q000821:virology; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D006801:Humans; D015160:Hydrops Fetalis / Q000453:epidemiology / Q000473:pathology / Q000821:virology; D009422:Nervous System Diseases / Q000196:embryology / Q000821:virology; D016732:Parvovirus B19, Human / Q000502:physiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000821:virology; D013921:Thrombocytopenia / Q000453:epidemiology / Q000473:pathology / Q000821:virology