title: [Protective effects of xuefu zhuyu decoction on myocardium ischemia reperfusion injury in rats].
abstract: OBJECTIVE
  To investigate the protective effects of Xuefu Zhuyu decoction on myocardium ischemia reperfusion injury in rats.
  
  
  METHODS
  36 SD rats were divided into 3 groups randomly, sham-operated group, model group, Xuefu Zhuyu decoction group. The model of MI/RI of the myocardium was reproduced by ligation of left descending artery for 30 min followed by releasing the ligation for 2 hours in rats. Serum contents of LDH-L, CK were measured, the levels of serum IL-1beta, IL-6 and IL-10 were measured and myocardial ultrastructure at the ischemia region was observed under the transmission electron microscope after myocardial reperfusion injury.
  
  
  RESULTS
  Compared with model group, IL-1beta, IL-6 and IL-10 levels were lower, myocardial ultrastructural changes were improved in Xuefu Zhuyu decoction group (P < 0.01), however, serum contents of LDH-L and CK no significant difference were found among the model group and Xuefu Zhuyu decoction group.
  
  
  CONCLUSIONS
  Xuefu Zhuyu decoction can protect myocardium from MI/RI, the mechanism of action was related to inhibiting inflammatory reaction and reducing arrhythmia and the injury of the myocardial ultrastructure.
authors.affiliation: Experimental Research Center of China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Danli
authors.initials: D
authors.lastname: Tang
authors.forename: Zhaihua
authors.initials: Z
authors.lastname: Liu
authors.forename: Huamin
authors.initials: H
authors.lastname: Zhang
authors.forename: Mingjie
authors.initials: M
authors.lastname: Sun
authors.forename: Yu
authors.initials: Y
authors.lastname: Sui
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D020011:Protective Agents / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D020011:Protective Agents; C513826:Xue-Fu-Zhu-Yu decoction; D016753:Interleukin-10