title: Effects of aspirin on distortion product fine structure: interpreted by the two-source model for distortion product otoacoustic emissions generation.
abstract: Distortion product otoacoustic emission (DPOAE) fine structure is due to the interaction of two major components coming from different places in the cochlea. One component is generated from the region of maximal overlap of the traveling waves generated by the two primaries and is attributed to nonlinear distortion (nonlinear component). The other component arises predominantly from the tonotopic region of the distortion product and is attributed to linear coherent reflection (reflection component). Aspirin (salicylate) ototoxicity can cause reversible hearing loss and reduces otoacoustic emission generation in the cochlea. The two components are expected to be affected differentially by cochlear health. Changes in DPOAE fine structure were recorded longitudinally in three subjects before, during, and after aspirin consumption. Full data sets were analyzed for two subjects, but only partial data could be analyzed from the third subject. Resulting changes in the two components of DPOAE fine structure revealed variability among subjects and differential effects on the two components. For low-intensity primaries, both components were reduced with the reflection component being more vulnerable. For high-intensity primaries, the nonlinear component showed little or no change, but the reflection component was always reduced.
authors.affiliation: Department of Speech-Language-Hearing Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA. raoxx098@umn.edu
authors.forename: Aparna
authors.initials: A
authors.lastname: Rao
authors.forename: Glenis R
authors.initials: GR
authors.lastname: Long
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000633:toxicity*; D001299:Audiometry; D001309:Auditory Threshold; D003051:Cochlea / Q000187:drug effects* / Q000503:physiopathology; D005583:Fourier Analysis; D034381:Hearing Loss / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D016018:Least-Squares Analysis; D008954:Models, Biological; D017711:Nonlinear Dynamics; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*; D011930:Reaction Time; D013997:Time Factors; D055815:Young Adult
chemical_list: D001241:Aspirin