title: [Secondary malignancies in late periods after chemoradiotherapy for lymphogranulomatosis in children].
abstract: The incidence of secondary malignancies (SM) was studied in a population of 219 patients in late periods (3-29 years) after childhood and adolescence chemoradiotherapy for Hodgkin's lymphoma (HL). SMs were found in 15 (6.8%) patients. These were solid neoplasms located in the irradiated areas in 12 of them, including 4 patients with thyroid cancer and 2 with gastric cancer. All 3 cases of acute leukemia had occurred after chemoradiotherapy performed by extended programs that consisted of a large number of chemotherapy cycles. The detection rate of SM did not significantly depend on the dose of radiation, age at start of treatment, and a child's gender. The findings suggest that there is a need for the maximum concentration of an irradiation beam in the area of thyroid lesion and exposure, for limited cytotoxic therapy programs, and lifetime medical observation of the patients treated for HL in childhood.
authors.forename: R A
authors.initials: RA
authors.lastname: Parkhomenko
authors.forename: O I
authors.initials: OI
authors.lastname: Shcherbenko
authors.forename: N I
authors.initials: NI
authors.lastname: Zelinskaia
authors.forename: R Ia
authors.initials: RIa
authors.lastname: Snigireva
authors.forename: E F
authors.initials: EF
authors.lastname: Khalil'
authors.forename: G V
authors.initials: GV
authors.lastname: Ardatova
authors.forename: N L
authors.initials: NL
authors.lastname: Chazova
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D015994:Incidence; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000517:prevention & control; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000517:prevention & control