title: NO points to epigenetics in vascular development.
abstract: Our understanding of epigenetic mechanisms important for embryonic vascular development and cardiovascular differentiation is still in its infancy. Although molecular analyses, including massive genome sequencing and/or in vitro/in vivo targeting of specific gene sets, has led to the identification of multiple factors involved in stemness maintenance or in the early processes of embryonic layers specification, very little is known about the epigenetic commitment to cardiovascular lineages. The object of this review will be to outline the state of the art in this field and trace the perspective therapeutic consequences of studies aimed at elucidating fundamental epigenetic networks. Special attention will be paid to the emerging role of nitric oxide in this field.
authors.affiliation: Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Illi
authors.forename: Claudia
authors.initials: C
authors.lastname: Colussi
authors.forename: Jessica
authors.initials: J
authors.lastname: Rosati
authors.forename: Francesco
authors.initials: F
authors.lastname: Spallotta
authors.forename: Simona
authors.initials: S
authors.lastname: Nanni
authors.forename: Antonella
authors.initials: A
authors.lastname: Farsetti
authors.forename: Maurizio C
authors.initials: MC
authors.lastname: Capogrossi
authors.forename: Carlo
authors.initials: C
authors.lastname: Gaetano
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000196:embryology* / Q000378:metabolism*; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D008648:Mesoderm / Q000196:embryology / Q000378:metabolism; D008955:Models, Cardiovascular; D008957:Models, Genetic; D009569:Nitric Oxide / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D009569:Nitric Oxide