title: [Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].
abstract: Host cell protein phosphatase-1 (PP1) is an important regulator of human immunodeficiency virus-1 (HIV-1) transcription. PP1 is involved in the regulation of HIV-1 transcription, and dephosphorylates RNA polymerase II C-terminal domain (RNAPII CTD) or CycT1-dependent kinase 9 (CDK9) to increase Tat-dependent HIV-1 transcription. In this review, we discuss the action of PP1 in Tat-induced HIV-1 transcription and related to PP1 inhibitors.
authors.affiliation: Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Xin-Yong
authors.initials: XY
authors.lastname: Liu
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D019319:Okadaic Acid / Q000494:pharmacology; D054645:Protein Phosphatase 1 / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000502:physiology*; D011714:Pyrans / Q000494:pharmacology; D013141:Spiro Compounds / Q000494:pharmacology; D014158:Transcription, Genetic; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000502:physiology*
chemical_list: D019380:Anti-HIV Agents; D004791:Enzyme Inhibitors; D011714:Pyrans; D013141:Spiro Compounds; D054322:tat Gene Products, Human Immunodeficiency Virus; C053079:tautomycin; D019319:Okadaic Acid; D054645:Protein Phosphatase 1