title: Pore formation in phospholipid bilayers by branched-chain pyrogallol[4]arenes.
abstract: Pyrogallolarenes are tetrameric macrocycles that form from 1,2,3-trihydroxybenzene and aldehydes under acidic conditions. When 2-ethylbutanal or 2-propylpentanal was so treated, the branched-chain pyrogallolarenes crystallized as nanotubes or bilayers, respectively. When the behavior of each compound was assessed by using the planar bilayer conductance method, pore formation was observed. The properties of the pores were significantly different from each other, probably reflecting different types of pore organization within the membrane.
authors.affiliation: Center for Nanoscience, Department of Chemistry & Biochemistry, University of Missouri-Saint Louis, Saint Louis, Missouri 63121, United States.
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Negin
authors.forename: Megan M
authors.initials: MM
authors.lastname: Daschbach
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Kulikov
authors.forename: Nigam
authors.initials: N
authors.lastname: Rath
authors.forename: George W
authors.initials: GW
authors.lastname: Gokel
mesh_terms: D047250:Calixarenes / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D016062:Porosity; D011748:Pyrogallol / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D008051:Lipid Bilayers; D010743:Phospholipids; C522570:pyrogallol(4)arene; D011748:Pyrogallol; D047250:Calixarenes