title: Quantitation of FISH Signals in Archival Tumors.
abstract: The term interphase cytogenetics was first used in 1986 by Cremer (1,2) to describe detection of chromosomal alterations using in situ techniques in interphase nuclei. This was a distinct advantage over conventional analyses as solid tumors could now be studied (2,3) and the possibility of applying the technique to specimens received in a diagnostic laboratory realised (4). The nonradioactive in situ method, fluorescence in situ hybridization (FISH), has been widely applied to study chromosomal rearrangements, malignancies, and chromosome mapping (4).
authors.affiliation: Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Watters
authors.forename: J M
authors.initials: JM
authors.lastname: Bartlett