title: Gastric cancer with choriocarcinoma and yolk sac tumor components: case report.
abstract: Choriocarcinoma- and yolk sac tumor-like differentiation have rarely been reported in gastric cancers. We report a case of gastric adenocarcinoma, concurrently possessing choriocarcinoma and yolk sac tumor components, of a 74-year-old man. A hemorrhagic, 11 × 8 × 3 cm, tumor with ulceration was located in the body and pre-pylorus of the stomach. Histological examination of the resected specimens demonstrated intermingled proliferation of three different components, namely, adenocarcinoma, choriocarcinoma and yolk sac tumor, which were immunoreactive for carcinoembryonic antigen (CEA), beta-subunit of human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP), respectively. Gastric cancers with germ cell tumor components are uncommon and this is the second reported case of gastric cancer with choriocarcinoma and yolk sac tumor components.
authors.affiliation: Department of Diagnostic Pathology, Tokushima Prefectural Central Hospital, Tokushima, Japan. nsatake-ind@umin.ac.jp
authors.forename: Nobuo
authors.initials: N
authors.lastname: Satake
authors.forename: Motoya
authors.initials: M
authors.lastname: Chikakiyo
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yagi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Takanori
authors.initials: T
authors.lastname: Hirose
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary* / Q000628:therapy; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D014408:Biomarkers, Tumor / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D002822:Choriocarcinoma / Q000378:metabolism / Q000556:secondary* / Q000628:therapy; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000378:metabolism; D002945:Cisplatin / Q000627:therapeutic use; D018572:Disease-Free Survival; D004338:Drug Combinations; D018240:Endodermal Sinus Tumor / Q000378:metabolism / Q000556:secondary* / Q000628:therapy; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary; D010094:Oxonic Acid / Q000627:therapeutic use; D018714:Radiotherapy, Adjuvant; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D005641:Tegafur / Q000627:therapeutic use; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004338:Drug Combinations; D000509:alpha-Fetoproteins; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin