title: Nuclear receptors as new perspective for the management of liver diseases.
abstract: Nuclear receptors (NRs) are ligand-activated transcription factors that act as sensors for a broad range of natural and synthetic ligands and regulate several key hepatic functions including bile acid homeostasis, bile secretion, lipid and glucose metabolism, as well as drug deposition. Moreover, NRs control hepatic inflammation, regeneration, fibrosis, and tumor formation. Therefore, NRs are key for understanding the pathogenesis and pathophysiology of a wide range of hepatic disorders. Finally, targeting NRs and their alterations offers exciting new perspectives for the treatment of liver diseases.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria. michael.trauner@meduniwien.ac.at
authors.forename: Michael
authors.initials: M
authors.lastname: Trauner
authors.forename: Emina
authors.initials: E
authors.lastname: Halilbasic
mesh_terms: D006801:Humans; D008107:Liver Diseases / Q000503:physiopathology* / Q000628:therapy*; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear