title: Clever leukemic stem cells branch out.
abstract: Individual tumors harbor heterogeneous populations of genetically distinct subclones. Two recent papers in Nature by Notta et al. (2011) and Anderson et al. (2011) reveal genetic heterogeneity in functional leukemic stem cells, which has important implications for how both cancer and normal stem cell populations may adapt to selective pressure.
authors.affiliation: MRC Molecular Haematology Unit, Radcliffe Hospital, Oxford OX3 9DU, UK. paresh.vyas@imm.ox.ac.uk
authors.forename: Paresh
authors.initials: P
authors.lastname: Vyas
authors.forename: Sten Eirik W
authors.initials: SE
authors.lastname: Jacobsen