title: Squamous cell carcinoma of the vagina and cervix in sheep - case report.
abstract: This report describes the clinical and histopathological characteristics of a squamous cell carcinoma infiltrating the cervix and the vaginal wall, producing reproductive symptoms and subnormal fertility in an adult ewe. Necropsy showed a large (15-cm-long) neoplastic mass infiltrating the vaginal wall and the cervix. Histopathological examination revealed atypical squamous epithelial cords invading the basal membrane and dermis, round anaplastic cells, focal areas of necrosis, keratinisation of isolated cells, and pronounced infiltration by mononuclear cells around the cords. No squamous cell carcinoma of such localisation has been reported from sheep before. In humans, this tumour is the most common gynaecological malignancy in the world.
authors.affiliation: Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain. dlacasta@unizar.es
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Ferrer
authors.forename: Delia
authors.initials: D
authors.lastname: Lacasta
authors.forename: Juan Jose
authors.initials: JJ
authors.lastname: Ramos
authors.forename: Jose Antonio García
authors.initials: JA
authors.lastname: Jalón
authors.forename: Marta
authors.initials: M
authors.lastname: Ruiz De Arcaute
authors.forename: Tomás
authors.initials: T
authors.lastname: Conde
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000662:veterinary*; D005260:Female; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000662:veterinary*; D014625:Vaginal Neoplasms / Q000473:pathology / Q000662:veterinary*