title: A local basis for progesterone action during mammary tumorigenesis - no longer RANK and file.
abstract: Two recent reports provide compelling insights into the role for RANK and its ligand, RANKL, in progestin-dependent mammary tumorigenesis. These findings build upon a considerable body of evidence pointing to the RANK signaling pathway as being a key mediator of progestin action in the mammary glands.
authors.affiliation: Department of Animal Science, University of California Davis, 2145 Meyer Hall, One Shields Avenue, Davis, CA 95616, USA.
authors.forename: Whitney K
authors.initials: WK
authors.lastname: Petrie
authors.forename: Russell C
authors.initials: RC
authors.lastname: Hovey
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000187:drug effects*; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology*; D011372:Progestins / Q000009:adverse effects*; D053245:RANK Ligand / Q000378:metabolism*
chemical_list: D011372:Progestins; D053245:RANK Ligand