title: Thrombovascular events affect quality of life in patients with systemic lupus erythematosus.
abstract: OBJECTIVE
  To compare health-related quality of life (HRQOL) of patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) with and without previous thrombovascular events (TE).
  
  
  METHODS
  The Medical Outcomes Study Short-Form 36 (SF-36) was used to assess HRQOL in 5 patient groups: (1) primary APS (PAPS; n = 35); (2) APS associated to SLE (SAPS; n = 37); (3) SLE+TE without persistent positive antiphospholipid antibody (SLE+TE-aPL; n = 75); (4) SLE-TE+aPL (n = 71); and (5) SLE-TE-aPL (n = 608).
  
  
  RESULTS
  The data on both mental component summary and physical component summary (PCS) scores showed an impaired quality of life in all patient groups. Patients in the SLE+TE-aPL group had a lower PCS score compared to patients in the SLE-TE+aPL group.
  
  
  CONCLUSIONS
  The combination of SLE and TE has a more negative influence on reported HRQOL, compared to having SLE or APS alone.
authors.affiliation: Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Amaris K
authors.initials: AK
authors.lastname: Balitsky
authors.forename: Valentina
authors.initials: V
authors.lastname: Peeva
authors.forename: Jiandong
authors.initials: J
authors.lastname: Su
authors.forename: Elaheh
authors.initials: E
authors.lastname: Aghdassi
authors.forename: Eric
authors.initials: E
authors.lastname: Yeo
authors.forename: Dafna D
authors.initials: DD
authors.lastname: Gladman
authors.forename: Murray B
authors.initials: MB
authors.lastname: Urowitz
authors.forename: Paul R
authors.initials: PR
authors.lastname: Fortin
mesh_terms: D000328:Adult; D000368:Aged; D016736:Antiphospholipid Syndrome / Q000453:epidemiology* / Q000209:etiology; D015897:Comorbidity; D005260:Female; D006306:Health Surveys; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011788:Quality of Life; D013927:Thrombosis / Q000453:epidemiology*; D014652:Vascular Diseases / Q000453:epidemiology*; D020246:Venous Thrombosis / Q000453:epidemiology