title: The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer.
abstract: BACKGROUND
  Genetic variations in cancer patients may serve as important prognostic indicators of clinical outcome. The GNAS1 T393C single nucleotide polymorphism (SNP) diversely correlates with the clinical outcome in cancer. The aim of this study was to evaluate the potential prognostic value of T393C-SNP in complete resected only surgically treated esophageal cancer (EC).
  
  
  METHODS
  Genomic DNA was extracted from peripheral blood leucocytes of 190 patients who underwent only complete surgical resection for EC. T393C-SNP was correlated with clinic-pathological parameters, tumor cell dissemination in bone marrow (DTC) and clinical outcome.
  
  
  RESULTS
  T-allele carriers had more advanced disease due to presence of lymph node metastasis (P < 0.0001) and DTC (P = 0.01) and higher recurrence rate (P = 0.01) compared to CC genotype. The disease-free (P < 0.001) and overall survival (P < 0.001) was better in CC compared to TT and TC patients. In the multivariate Cox regression disease-stage adjusted analysis the T393C-SNP was identified as a strong independent prognostic factor for recurrence (hazard ratio 1.8, P = 0.01) and survival (hazard ratio 2.5, P < 0.001) in EC patients.
  
  
  CONCLUSIONS
  Determination of T393C-SNP preoperatively will allow allocation of EC patients into different risk profiles which may help to stratify patients eligible for neoadjuvant and or adjuvant therapy.
authors.affiliation: Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Germany. vashist@uke.de
authors.forename: Yogesh Kumar
authors.initials: YK
authors.lastname: Vashist
authors.forename: Asad
authors.initials: A
authors.lastname: Kutup
authors.forename: Safije
authors.initials: S
authors.lastname: Musici
authors.forename: Emre F
authors.initials: EF
authors.lastname: Yekebas
authors.forename: Sormeh
authors.initials: S
authors.lastname: Mina
authors.forename: Guentac
authors.initials: G
authors.lastname: Uzunoglu
authors.forename: Oliver
authors.initials: O
authors.lastname: Zehler
authors.forename: Alexandra
authors.initials: A
authors.lastname: Koenig
authors.forename: Guelle
authors.initials: G
authors.lastname: Cataldegirmen
authors.forename: Maximillian
authors.initials: M
authors.lastname: Bockhorn
authors.forename: Katharina
authors.initials: K
authors.lastname: Effenberger
authors.forename: Viacheslav
authors.initials: V
authors.lastname: Kalinin
authors.forename: Klaus
authors.initials: K
authors.lastname: Pantel
authors.forename: Jakob R
authors.initials: JR
authors.lastname: Izbicki
mesh_terms: D000368:Aged; D002864:Chromogranins; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D005260:Female; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics*; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D002864:Chromogranins; C406732:GNAS protein, human; D019205:GTP-Binding Protein alpha Subunits, Gs