title: Candidatus Neoehrlichia mikurensis infection identified in 2 hematooncologic patients: benefit of molecular techniques for rare pathogen detection.
abstract: Hematooncologic patients often host rare or fastidious pathogens. Using 16S rDNA sequencing and transmission electron microscopy, we have identified 2 lymphoma patients infected with Candidatus Neoehrlichia mikurensis. In both individuals, the clinical presentation suggested ehrlichiosis-like syndrome. We believe that molecular techniques open new vistas in the field of pathogen detection.
authors.affiliation: Laboratory for Molecular Diagnostics, CHAMBON Laboratories, Prague, Czech Republic. pekovas@post.cz
authors.forename: Sona
authors.initials: S
authors.lastname: Pekova
authors.forename: Jan
authors.initials: J
authors.lastname: Vydra
authors.forename: Hana
authors.initials: H
authors.lastname: Kabickova
authors.forename: Sona
authors.initials: S
authors.lastname: Frankova
authors.forename: Renata
authors.initials: R
authors.lastname: Haugvicova
authors.forename: Oldrich
authors.initials: O
authors.lastname: Mazal
authors.forename: Radek
authors.initials: R
authors.lastname: Cmejla
authors.forename: David W
authors.initials: DW
authors.lastname: Hardekopf
authors.forename: Tereza
authors.initials: T
authors.lastname: Jancuskova
authors.forename: Tomas
authors.initials: T
authors.lastname: Kozak
mesh_terms: D000710:Anaplasmataceae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D000711:Anaplasmataceae Infections / Q000150:complications / Q000175:diagnosis*; D000818:Animals; D004269:DNA, Bacterial / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D016873:Ehrlichiosis / Q000175:diagnosis; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis / Q000382:microbiology; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D013987:Ticks / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial; D004275:DNA, Ribosomal