title: Allopurinol hypersensitivity syndrome with acute generalized exanthematous pustulosis manifestations.
abstract: Allopurinol hypersensitivity syndrome(AHS) is a severe form of cutaneous adverse reaction that is associated with significant morbidity and mortality. We report a case of AHS with the cutaneous manifestation of acute generalised exanthematous pustulosis(AGEP). A 47 year old gentleman, with no previous skin disease, presented with a generalized mildly pruritic erythematous rash on the trunk and all 4 limbs, with patches of superficial non-follicular pustules. Our patient fulfilled both criteria for AGEP and AHS.
authors.affiliation: Singapore General Hospital, Dermatology Unit, Singapore. wanlinteo@gmail.com
authors.forename: Wan Lin
authors.initials: WL
authors.lastname: Teo
authors.forename: Shiu Ming
authors.initials: SM
authors.lastname: Pang
authors.forename: Hong Yi
authors.initials: HY
authors.lastname: Koh
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D000493:Allopurinol / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006074:Gout Suppressants; D000493:Allopurinol