title: Transient ventricular hypocinesia after in utero anthracyclines exposure: a case-report and review of the literature.
abstract: Due to the low occurrence of cancer during pregnancy, limited data are available about outcome of infants exposed to chemotherapy in utero. We report the case of a newborn who developed transient ventricular hypocinesia and late-onset infection after in utero exposure to four epirubicin cycles for pregnancy-associated breast cancer. Moreover, we provide an overview of literature on neonatal outcome after anthracyclines-based chemotherapy regimen during pregnancy. Existing data support use of anthracyclines, as few cases of fetal cardiac toxicity were reported and most of short-term complications were transient. Need for prospective collection of data and longer follow-up is highly recognized.
authors.affiliation: Pediatric and Neonatology Unit, Department of Pediatrics, Ordine Mauriziano Hospital, University of Turin, Turin, Italy. emilia.parodi@unito.it
authors.forename: Emilia
authors.initials: E
authors.lastname: Parodi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Alluto
authors.forename: Giulia
authors.initials: G
authors.lastname: Moggio
authors.forename: Viola
authors.initials: V
authors.lastname: Liberale
authors.forename: Mario
authors.initials: M
authors.lastname: Frigerio
authors.forename: Piero
authors.initials: P
authors.lastname: Sismondi
mesh_terms: D000328:Adult; D018943:Anthracyclines / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced; D008297:Male; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011297:Prenatal Exposure Delayed Effects
chemical_list: D018943:Anthracyclines