title: The curative and antioxidative efficiency of ivermectin and ivermectin + vitamin E-selenium treatment on canine Sarcoptes scabiei infestation.
abstract: The objective of the present study was to investigate the curative and antioxidative efficacy of ivermectin and ivermectin + vitamin E-selenium, and the influence of these agents on oxidative stress parameters in canines infested by Sarcoptes scabiei. Twenty two sarcoptic mites infested dogs and nine healthy dogs of 6 months to 2 years of age were divided into three groups. Group I comprised of healthy dogs (n=9) whereas animals in group II (n=11) and III (n=11) were positive for scabies. Group II animals were treated with only 1% ivermectin @ 0.2 mg/kg SC whereas group III were additionally treated with Vitamin E and selenium (tocopherol 50 mg + Se 1.5 mg/ml) @ 0.5 ml/20 kg IM at weekly intervals for three times. Blood samples were collected on day 0 and 28 post therapy. The values for hemato-biochemical parameters and activities of antioxidant enzymes were significantly decreased (P<0.05) whereas level of lipid peroxidation was significantly increased in all the infested dogs in comparison to the healthy dogs on day 0 which approached normalcy by day 28 post therapy. The dogs of group III showed better clinical recovery in comparison to group II at the end of therapy. Thus, administration of vitamin E and selenium in addition to standard therapy can alleviate these alterations hastening the clinical recovery of diseased dogs and can be recommended as an adjunct therapy with miticides for canine sarcoptic mange.
authors.affiliation: Division of Medicine, Indian Veterinary Research Institute, Izatnagar, 243 122 Bareilly, UP, India. drsuvendu.kumar@gmail.com
authors.forename: Suvendu Kumar
authors.initials: SK
authors.lastname: Behera
authors.forename: Umesh
authors.initials: U
authors.lastname: Dimri
authors.forename: Shanker Kumar
authors.initials: SK
authors.lastname: Singh
authors.forename: Ranjan Kumar
authors.initials: RK
authors.lastname: Mohanta
mesh_terms: D056810:Acaricides / Q000627:therapeutic use; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004359:Drug Therapy, Combination / Q000379:methods; D007194:India; D007559:Ivermectin / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects*; D012520:Sarcoptes scabiei; D012532:Scabies / Q000188:drug therapy / Q000662:veterinary*; D012643:Selenium / Q000627:therapeutic use*; D012867:Skin; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D056810:Acaricides; D014810:Vitamin E; D007559:Ivermectin; D012643:Selenium