title: Suzuki-Miyaura cross-coupling coupling reactions with low catalyst loading: a green and sustainable protocol in pure water.
abstract: The Suzuki-Miyaura coupling reaction represents one of the most important synthetic transformations developed in the 20th century. However, the use of toxic organic solvents remains a scientific challenge and an aspect of economical and ecological relevance, and benign water as a reaction medium was found to be highly effective to overcome some of these issues. In the present manuscript, we described Suzuki-Miyaura coupling reactions in neat water, without using any phase transfer reagent. Notably, this protocol also works with ultra-low loading of catalyst with high turnover numbers and also able to couple challenging substrates like aryl chlorides.
authors.affiliation: KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology, Thuwal, 23955, Kingdom of Saudi Arabia. aziz.fihri@kaust.edu.sa
authors.forename: Aziz
authors.initials: A
authors.lastname: Fihri
authors.forename: Denis
authors.initials: D
authors.lastname: Luart
authors.forename: Christophe
authors.initials: C
authors.lastname: Len
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Solhy
authors.forename: Carole
authors.initials: C
authors.lastname: Chevrin
authors.forename: Vivek
authors.initials: V
authors.lastname: Polshettiwar
mesh_terms: D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D055772:Green Chemistry Technology; D010165:Palladium / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D014867:Water; D010165:Palladium