title: Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock.
abstract: OBJECTIVE
  To assess the prevalence and predictive value of natural autoantibodies to high-mobility group box 1 (HMGB1) during sepsis.
  
  
  METHODS
  Anti-HMGB1 and anti-human serum albumin (HSA) autoantibodies were detected by ELISA in 178 plasma samples longitudinally collected from 40 critically ill patients with septic shock. One hundred thirty-two plasma samples from healthy donors were used as control.
  
  
  RESULTS
  IgGs to HMGB1 were detected in 15/40 patients (37.5%). The prevalence of anti-HMGB1 antibodies was significantly higher in the patients who survived (55%) compared to the patients who did not (20%) (p<0.0001). The detection of anti-HMGB1 antibodies during the course of the disease was significantly associated with patient survival (p=0.038). Moreover, there is a progressive and significant emergence of anti-HMGB1 antibodies during the course of the disease, mostly in patients who survived.
  
  
  CONCLUSIONS
  This study shows that autoantibodies to HMGB1 are produced during sepsis and are associated with a favorable outcome in patients undergoing septic shock.
authors.affiliation: Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMRS 872, escalier F 2ème étage, 15 rue de l'école de médecine, Paris 75006, France. stephanie.barnay-verdier@upmc.fr
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Barnay-Verdier
authors.forename: Lakhdar
authors.initials: L
authors.lastname: Fattoum
authors.forename: Chloé
authors.initials: C
authors.lastname: Borde
authors.forename: Srini
authors.initials: S
authors.lastname: Kaveri
authors.forename: Sébastien
authors.initials: S
authors.lastname: Gibot
authors.forename: Vincent
authors.initials: V
authors.lastname: Maréchal
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005602:France; D024243:HMGB1 Protein / Q000276:immunology*; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D012772:Shock, Septic / Q000503:physiopathology*; D013534:Survival
chemical_list: D001323:Autoantibodies; D024243:HMGB1 Protein