title: Plasminogen and its receptors as regulators of cardiovascular inflammatory responses.
abstract: In addition to its role in fibrinolysis, plasminogen (Plg) influences inflammatory cell migration and thereby plays a prominent role in cardiovascular pathology. The contribution of Plg to inflammatory cell recruitment depends on its tethering to the surface of responding cells. Plasminogen receptors (Plg-Rs) are heterogeneous and can be classified as tailless, lacking cytoplasmic tails, or tailed (having cytoplasmic tails). In vivo observations implicate several tailless Plg-Rs in inflammatory responses. Tailed Plg-Rs on leukocytes include several integrins, which have also been implicated in Plg-dependent responses. Surface expression of both tailless and tailed Plg-Rs can be modulated in number and/or function. A common mechanism involving intracellular calcium mobilization and calcium channels regulates expression of both classes of Plg-Rs. Data are emerging to indicate that targeting Plg and Plg-Rs may limit inflammation and cardiovascular pathology.
authors.affiliation: Departmentof Molecular Cardiology, Lerner ResearchInstitute, Cleveland Clinic, Cleveland, OH 44130, USA.
authors.forename: Riku
authors.initials: R
authors.lastname: Das
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Pluskota
authors.forename: Edward F
authors.initials: EF
authors.lastname: Plow
mesh_terms: D015220:Calcium Channels; D005341:Fibrinolysin; D006331:Heart Diseases / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D016023:Integrins; D007962:Leukocytes / Q000502:physiology; D010958:Plasminogen
chemical_list: D015220:Calcium Channels; D016023:Integrins; D010958:Plasminogen; D005341:Fibrinolysin