title: [Acupuncture for chronic pelvic pain syndromes (CPPS) and its effect on cytokines in prostatic fluid].
abstract: OBJECTIVE
  To explore the effect of acupuncture on chronic pelvic pain syndromes (CPPS), and its therapeutic mechanism.
  
  
  METHODS
  Fourty-seven cases of CPPS were treated with electroacupuncture on Zhongji (CV 3), Guilai (ST 29), Yinlingquan (SP 9), Sanyinjiao (SP 6), Guanyuan (CV 4), Shuidao(ST 28), Xuehai (SP 10) and Taichong (LR 3) as main acupoints. Chronic Prostatitis Symptom Index (CPSI) was adopted to grade the severity of pain or discomforts. Additionally, the levels of Interleukin-8 (IL-8), Interleukin-10 (IL-10) and Tumor necrosis factor-alpha (TNF-alpha) in prostate fluid were detected and the correlation between those changes and pain score was analyzed.
  
  
  RESULTS
  After treatment, pain or discomfort score in CPSI decreased remarkably as compared with that before treatment (P < 0.01). The levels of IL-8, IL-10 and TNF-alpha were lower than those before treatment (P < 0.01, P < 0.05). The positive correlation was obtained between IL-10 level and pain score (P < 0.05). The total effective rate was 89.4% (42/47).
  
  
  CONCLUSIONS
  Acupuncture has significant efficacy on CPPS through reducing IL-10 level to ease pain, and reducing the levels of IL-8 and TNF-alpha to relieve inflammatory reaction.
authors.affiliation: Male Department of Zhuhai Branch of Guangdong Provincial TCM Hospital, Zhuhai 519000, China. ysy017@126.com
authors.forename: Shao-Ying
authors.initials: SY
authors.lastname: Yuan
authors.forename: Zhan
authors.initials: Z
authors.lastname: Qin
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Liu
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Yin
authors.forename: Zhao-Lei
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Shen-Guo
authors.initials: SG
authors.lastname: Li
mesh_terms: D015669:Acupuncture Points; D015670:Acupuncture Therapy; D000328:Adult; D001826:Body Fluids / Q000276:immunology*; D002908:Chronic Disease / Q000628:therapy; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D016209:Interleukin-8 / Q000276:immunology; D008297:Male; D008875:Middle Aged; D017699:Pelvic Pain / Q000276:immunology* / Q000628:therapy*; D011467:Prostate / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D055815:Young Adult
chemical_list: D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10