title: [Expression of SATB1 and BRMS1 in ovarian serous adenocarcinoma and its relationship with clinieopathological features].
abstract: OBJECTIVE
  To study the expression and clinical significance of SATB1, BRMS1 in Ovarian serous adenocarcinoma.
  
  
  METHODS
  Immanohistochemistrical SP method was used to detect the expression of SATB1, BRMS1 in 11 cases of normal ovarian tissue and 11 cases of benign ovarian tumor and 10 cases of ovarian borderline tumor and 53 cases ovarian serous adenocarcinoma.
  
  
  RESULTS
  The expression of SATB1 in ovarian serous adenocarcinoma (86.8%) was significantly higher than those of normal ovarian tissues (0) and benign ovarian tumor tissues (36.4%), P < 0.05, and there was no difference between ovarian borderline tumor (70%) and ovarian serous adenocarcinoma, P > 0.05. The expression of BRMS1 in ovarian serous adenocarcinoma (28. 3%) was significantly lower than those in normal ovarian tissues (100%) and benign ovarian tumor tissues (81.8%), P < 0. 05, and there was no difference between ovarian borderline tumor (60%) and ovarian serous adenocarcinoma, P > 0.05. The inverse correlation between the expression of SATB1 and BRMS1 was observed (r = -0.387, P < 0.05). The expression of SATB1 was correlated with surgical stage and lymph node metastasis (P < 0.05), BRMS1 was correlated with surgical stage, lymph node metastasis and tumor size (P < 0.05); SATB1 and BRMS1 had no correlation with the patients whether menopause or not, histopathological grading, ascites (P > 0.05).
  
  
  CONCLUSIONS
  SATB1 and BRMS1 might play an important role in the development and lymph node metastasis of ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Xiao-lan
authors.initials: XL
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D036961:Matrix Attachment Region Binding Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D012097:Repressor Proteins
chemical_list: C410024:BRMS1 protein, human; D036961:Matrix Attachment Region Binding Proteins; D009363:Neoplasm Proteins; D012097:Repressor Proteins; C076189:SATB1 protein, human