title: Positional photocleavage control of DNA-based nanoswitches.
abstract: DNA-based switches are currently operated by manual solution-phase addition of 'set-strands'. We demonstrate another operation method-sterically inaccessible 'set-strands', released from a surface into solution by spatially controlled photocleavage. This technique will enable microarrays of set-strands to operate many DNA-based switches in self-contained computational and diagnostic devices.
authors.affiliation: California State Polytechnic University Pomona, Department of Chemistry, 3801 W Temple Avenue, Pomona, CA 91768, USA.
authors.forename: Allen K
authors.initials: AK
authors.lastname: Mok
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Kedzierski
authors.forename: Paul N
authors.initials: PN
authors.lastname: Chung
authors.forename: Philip S
authors.initials: PS
authors.lastname: Lukeman
mesh_terms: D020029:Base Pairing; D015374:Biosensing Techniques / Q000379:methods; D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D056656:Lab-On-A-Chip Devices; D008027:Light; D046208:Microchip Analytical Procedures; D036103:Nanotechnology / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D055668:Photochemical Processes; D012996:Solutions / Q000737:chemistry / Q000378:metabolism
chemical_list: D012996:Solutions; D004247:DNA