title: In-vivo magnetic resonance imaging of the structural core of the Papez circuit in humans.
abstract: Papez circuit is one of the major pathways of the limbic system, and it is involved in the control of memory and emotion. Structural and functional alterations have been reported in psychiatric, neurodegenerative, and epileptic diseases. Despite the clinical interest, however, in-vivo imaging of the entire circuit remains a technological challenge. We used magnetic resonance diffusion spectrum imaging to comprehensively picture the Papez circuit in healthy humans: (i) the hippocampus-mammillary body pathway, (ii) the connections between the lateral subiculum and the cingulate cortex, and (iii) the mammillo-thalamic tract. The diagnostic and therapeutic implications of these results are discussed in the context of recent findings reporting the involvement of the Papez circuit in neurological and psychiatric diseases.
authors.affiliation: Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. cristina.granziera@chuv.ch
authors.forename: Cristina
authors.initials: C
authors.lastname: Granziera
authors.forename: Nouchine
authors.initials: N
authors.lastname: Hadjikhani
authors.forename: Shahar
authors.initials: S
authors.lastname: Arzy
authors.forename: Margitta
authors.initials: M
authors.lastname: Seeck
authors.forename: Reto
authors.initials: R
authors.lastname: Meuli
authors.forename: Gunnar
authors.initials: G
authors.lastname: Krueger
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008032:Limbic System / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000033:anatomy & histology*