title: [Design, synthesis of quinolinone acid-containing compounds with anti-HIV integrase activity].
abstract: A series of novel quinolinone acid-containing compounds were designed and synthesized. Their structures were confirmed with 1H NMR and MS. The target compounds were tested for anti-HIV-1 integrase activities in vitro with enzyme linked immunosorbent assay (ELISA). The result showed that D-2, D-4 and D-7 have anti-integrase activity with IC50 < 100 micromol L(-1).
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Xiao-fang
authors.initials: XF
authors.lastname: Chen
authors.forename: Yan-bin
authors.initials: YB
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
authors.forename: Rui-zhen
authors.initials: RZ
authors.lastname: Wang
authors.forename: Chong
authors.initials: C
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
mesh_terms: D019427:HIV Integrase / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D019428:HIV Integrase Inhibitors; D015363:Quinolones; D019427:HIV Integrase