title: Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients.
abstract: Environmental factors contribute to the increased prevalence of autoimmune diseases via T helper type-17 cell (Th17) activation. Tobacco smoking increases the risk of psoriasis, but the mechanisms are not clear. We evaluated the percentage of circulating Th17 among CD3(+) cells in peripheral blood mononuclear cells (PBMC) obtained from 27 healthy volunteers (2.58±0.80%), 33 smoker (3.55±1.33%) and 21 non-smoker (3.10±1.14%) patients with psoriasis to elucidate the relation between smoking and psoriasis. More smokers (19/33) than non-smokers (6/21) had high Th17 levels (Th17/CD3>3.38%, mean+1 SD of healthy volunteers). Tobacco smoke extract (TSE, 7μl/ml) induced Th17 generation from central memory T cells in vitro. TSE increased interleukin 17 and 22 expression. These findings demonstrate the relation between tobacco smoke and IL-17 and IL-22, which exacerbate psoriasis.
authors.forename: Kan
authors.initials: K
authors.lastname: Torii
authors.forename: Chiyo
authors.initials: C
authors.lastname: Saito
authors.forename: Takuya
authors.initials: T
authors.lastname: Furuhashi
authors.forename: Akiko
authors.initials: A
authors.lastname: Nishioka
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Shintani
authors.forename: Kana
authors.initials: K
authors.lastname: Kawashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kato
authors.forename: Akimichi
authors.initials: A
authors.lastname: Morita
mesh_terms: D000328:Adult; D000368:Aged; D017252:CD3 Complex / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism; D018655:Lymphocyte Count; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology*; D012907:Smoking / Q000009:adverse effects / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism*; D055815:Young Adult; D000097043:Interleukin-22
chemical_list: D017252:CD3 Complex; D020381:Interleukin-17; D007378:Interleukins; D000097043:Interleukin-22