title: Frequent overlap of active hepatitis in recurrent primary sclerosing cholangitis after living-donor liver transplantation relates to its rapidly progressive course.
abstract: Recurrence of primary sclerosing cholangitis after liver transplantation is a challenging issue. Liver pathologies of recurrent primary sclerosing cholangitis after living-donor liver transplantation have not been reported. Here, liver pathologies of explanted grafts and biopsies of 9 patients who underwent retransplantation for recurrent primary sclerosing cholangitis were compared with those of native livers. Recurrence was diagnosed in 13 of 36 patients for primary sclerosing cholangitis post-living-donor liver transplantation, and 9 of them underwent retransplantation. All explanted grafts revealed biliary cirrhosis with sclerosing cholangitis, and 6 patients had additional features of active hepatitis. Liver biopsies showed that 3 had active hepatitis in addition to fibrous cholangitis at recurrence of primary sclerosing cholangitis. Two developed active hepatitis later after the diagnosis of recurrence. In explanted grafts, in addition to extensive hilar lymphoplasmacytic cholangitis, 4 cases showed hilar xanthogranulomatous cholangitis. The latter was not evident in 7 native livers. Ductopenia was extensive in all native livers, although such changes were relatively mild in explanted grafts at retransplantation. Patients with recurrent primary sclerosing cholangitis developed progressive graft failure, and the interval between diagnosis of recurrence and retransplantation (mean, 3.2 years) was shorter than that between diagnosis of primary sclerosing cholangitis and first transplantation (mean, 7.7 years). The rather rapid deterioration of recurrent primary sclerosing cholangitis after liver transplantation may be related to the frequent overlap of active hepatitis.
authors.affiliation: Department of Diagnostic Pathology, Kyoto University Hospital, 606-8507 Kyoto, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Miyagawa-Hayashino
authors.forename: Hiroto
authors.initials: H
authors.lastname: Egawa
authors.forename: Atsusi
authors.initials: A
authors.lastname: Yoshizawa
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Ueda
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ichida
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Shinji
authors.initials: S
authors.lastname: Uemoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.forename: Yasuni
authors.initials: Y
authors.lastname: Nakanuma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002675:Child, Preschool; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006084:Graft Rejection; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012086:Reoperation