title: A strategy for the targeting of photosensitizers. Synthesis, characterization, and photobiological property of porphyrins bearing glycodendrimeric moieties.
abstract: This paper describes the conception, synthesis, and characterization of new tetrapyrrolic chromophores bearing glycodendrimeric moieties inducing a potential increase of tumor targeting by a cluster effect. Two families of monoglycodendrimeric photosensitizers bearing three glycosyl units were designed, prepared with an acceptable overall efficiency and characterized by NMR, UV-visible, and fluorescence spectroscopies. The polarity and log P were evaluated by HPLC and the stir-flask method, respectively. The in vitro photoefficiency against two human tumor cell lines was assessed. The presence of the glycodendrimeric group does not appear to increase the tumor in vitro targeting.
authors.affiliation: UMR 176 CNRS/Institut Curie, Institut Curie, Bât 110, University Paris-Sud, F-91405 Orsay, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Ballut
authors.forename: Delphine
authors.initials: D
authors.lastname: Naud-Martin
authors.forename: Bernard
authors.initials: B
authors.lastname: Loock
authors.forename: Philippe
authors.initials: P
authors.lastname: Maillard
mesh_terms: D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry*; D006031:Glycosylation; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018462:Photobiology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D045725:Tetrapyrroles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D008081:Liposomes; D017319:Photosensitizing Agents; D011166:Porphyrins; D045725:Tetrapyrroles