title: In-silico analysis and QSAR studies of tacrine hybrids with ubiquitin ligase on Alzheimer's disease.
abstract: Ubiquitin ligase was an important protease in the pathogenesis of Alzheimer's Disease (AD). Currently, a handful of drugs were available and they are at best only able to offer some relief from symptoms. Cure for this disease is currently not available. Tacrine hybrids show inhibitory activities to the ubiquitin ligase. The three-dimensional quantitative structure?activity relationship (3D QSAR) models and in-silico studies would be useful in developing new drug leads against Alzheimer's disease. The objective of this work involves the designing of new substances, with potential inhibitory activity over AcetylCholinesterase Enzyme (AChE), using rational drug design strategies.
authors.affiliation: Department of Pharmacoinformatics, School of Chemical and Biotechnology, Sastra University, Tanjore 613 402, Tamil Nadu, India. sumipandianinfo@gmail.com
authors.forename: R Sumi
authors.initials: RS
authors.lastname: Pandian
authors.forename: K
authors.initials: K
authors.lastname: Hemavathi
authors.forename: R
authors.initials: R
authors.lastname: Jayapradha
authors.forename: R
authors.initials: R
authors.lastname: Seenivasagam
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D021281:Quantitative Structure-Activity Relationship; D013329:Structure-Activity Relationship; D013619:Tacrine / Q000737:chemistry* / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D002800:Cholinesterase Inhibitors; D013619:Tacrine; D044767:Ubiquitin-Protein Ligases