title: [Intestinal absorption properties of three components in salvianolic acid extract and the effect of borneol on their absorption in rats].
abstract: This study aimed to investigate the effects of concentration, intestinal section and borneol on the intestinal absorption of salvianolic acids. The experiment not only studied the intestinal absorption properties of three concentrations of rosmarinic acid, salvianolic acid B and salvianolic acid A at duodenum, jejunum and ileum, but also of salvianolic acids compatible with borneol at different concentrations using single-pass intestinal perfusion model in rat with phenol red as the marker. The results showed that salvianolic acids was stable under weak-acid condition and affected by metabolism enzyme; The Peff and Ka significantly different among three concentrations of rosmarinic acid and salvianolic acid B, whose intestinal absorption were saturated in high concentration, suggesting that the transport mechanisms of rosmarinic acid and salvianolic acid B were similar to active transport or facilitated diffusion; However, there was inconspicuousness in the Peff and Ka of salvianolic acid A at different concentrations, whose absorption was not saturated in high concentration, indicating that the transport mechanisms of salvianolic acid A was passive diffusion; The Peff and Ka in the ileum obviously higher than those in the duodenum and jejunum, namely the ileum was the best absorption section; When concentration of borneol increased, the enhancing effect of intestinal absorption of salvianolic acids increased, but significantly decreased when borneol increased to some degree. The enhancing effect of medium borneol concentration was the optimum. This implied that borneol can enhance the intestinal absorption of salvianolic acids, and the capacity of enhancing effect was influenced by the concentration of borneol.
authors.affiliation: School of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China.
authors.forename: Xiao-juan
authors.initials: XJ
authors.lastname: Lai
authors.forename: Han-qing
authors.initials: HQ
authors.lastname: Liu
authors.forename: Jun-song
authors.initials: JS
authors.lastname: Li
authors.forename: Liu-qing
authors.initials: LQ
authors.lastname: Di
authors.forename: Bao-chang
authors.initials: BC
authors.lastname: Cai
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000302:isolation & purification / Q000493:pharmacokinetics*; D002109:Caffeic Acids / Q000302:isolation & purification / Q000493:pharmacokinetics*; D001892:Camphanes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D002934:Cinnamates / Q000302:isolation & purification / Q000493:pharmacokinetics*; D053630:Depsides / Q000302:isolation & purification / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000378:metabolism; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism; D007773:Lactates / Q000302:isolation & purification / Q000493:pharmacokinetics*; D008297:Male; D010477:Perfusion / Q000379:methods; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza / Q000737:chemistry; D000097123:Rosmarinic Acid
chemical_list: D001572:Benzofurans; D002109:Caffeic Acids; D001892:Camphanes; D002934:Cinnamates; D053630:Depsides; D007773:Lactates; D000097123:Rosmarinic Acid; C066201:salvianolic acid A; C076944:salvianolic acid B; C022871:isoborneol