title: Differences in breast tissue oxygenation following radiotherapy.
abstract: Tissue perfusion and oxygenation changes following radiotherapy may result from and/or contribute to the toxicity of treatment. Breast tissue oxygenation levels were determined in the treated and non-treated breast 1 year after radiotherapy for breast conserving treatment. Transcutaneous oxygenation varied between subjects in both treated and non-treated breast. Subjects without diabetes mellitus (n=16) had an average oxygenation level of 64.8 ± 19.9mmHg in the irradiated breast and an average of 72.3 ± 18.1mmHg (p=0.018) at the corresponding location in the control breast. Patients with diabetes (n=4) showed a different oxygenation pattern, with lower oxygenation levels in control tissue and no decrease in the irradiated breast. This study suggests oxygenation levels in normal tissues vary between patients and may respond differently after radiotherapy.
authors.affiliation: Department of Radiation Oncology, St. Mary's Duluth Clinic Health System, USA. kdornfeld@smdc.org
authors.forename: Ken
authors.initials: K
authors.lastname: Dornfeld
authors.forename: Charles E
authors.initials: CE
authors.lastname: Gessert
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Renier
authors.forename: David D
authors.initials: DD
authors.lastname: McNaney
authors.forename: Rodolfo E
authors.initials: RE
authors.lastname: Urias
authors.forename: Denise M
authors.initials: DM
authors.lastname: Knowles
authors.forename: Jean L
authors.initials: JL
authors.lastname: Beauduy
authors.forename: Sherry L
authors.initials: SL
authors.lastname: Widell
authors.forename: Bonita L
authors.initials: BL
authors.lastname: McDonald
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D008875:Middle Aged; D009593:Nitroimidazoles / Q000494:pharmacology; D010100:Oxygen / Q000378:metabolism*; D012867:Skin / Q000378:metabolism
chemical_list: D009593:Nitroimidazoles; C033815:pimonidazole; D010100:Oxygen