title: The long and winding road from correlation to causation.
abstract: Follow-up studies of a Crohn's disease risk locus encompassing IRGM have revealed unexpected complexity. A new study shows that a synonymous variant in the IRGM coding region alters a binding site for miR-196 and modulates IRGM-dependent autophagy, adding to the list of possible mechanisms by which this locus influences disease risk.
authors.forename: Michel
authors.initials: M
authors.lastname: Georges
mesh_terms: D001343:Autophagy / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics*; D019204:GTP-Binding Proteins / Q000235:genetics*; D035683:MicroRNAs; D012306:Risk
chemical_list: C542543:MIRN196 microRNA, human; D035683:MicroRNAs; D019204:GTP-Binding Proteins; C513539:IRGM protein, human