title: Postprocedural serum sLOX-1 levels are associated with coronary in-stent restenosis in patients with stable coronary artery disease.
abstract: OBJECTIVE
  We tested whether serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels are able to predict in-stent restenosis (ISR) after successful primary percutaneous coronary intervention (PCI).
  
  
  METHODS
  Preprocedural and postprocedural serum sLOX-1 levels were measured in 210 consecutive patients with stable coronary artery disease who underwent successful primary PCI for de novo lesions. The patients were grouped as ISR and non-ISR based on angiographic follow-up results.
  
  
  RESULTS
  PCI significantly increased serum sLOX-1 levels both in patients with [0.85 (range: 0.63-0.98) vs. 0.39 (range: 0.27-0.54) ng/ml, P < 0.01] or without ISR [0.45 (range: 0.36-0.84) vs. 0.32 (range: 0.28-0.62) ng/ml, P < 0.01]. Postprocedural serum sLOX-1 levels were higher in patients with ISR than those without ISR [0.85 (range: 0.63-0.98) vs. 0.45 (range: 0.36-0.84) ng/ml, P < 0.01]. High postprocedural serum sLOX-1 levels served as independent predictors of ISR (odds ratio: 3.040, 95% confidence interval: 1.359-6.802, P < 0.01). Furthermore, postprocedural serum sLOX-1 levels were correlated with late lumen loss of the stented lesions (ρ = 0.36, P < 0.01).
  
  
  CONCLUSIONS
  Postprocedural serum sLOX-1 levels are significantly associated with the risk of ISR and the severity of lumen loss in patients with stable coronary artery disease undergoing primary PCI. These results suggested that postprocedural serum sLOX-1 levels might be useful for the detection and risk assessment of ISR after PCI.
authors.affiliation: Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xian, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Zhang
authors.forename: Xin-guo
authors.initials: XG
authors.lastname: Yang
authors.forename: Yin
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiong-tao
authors.initials: XT
authors.lastname: Liu
authors.forename: Yin-gang
authors.initials: YG
authors.lastname: Ren
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003324:Coronary Artery Disease / Q000097:blood*; D023903:Coronary Restenosis / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011446:Prospective Studies; D051127:Scavenger Receptors, Class E / Q000097:blood*; D012720:Severity of Illness Index; D015607:Stents
chemical_list: C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E