title: Roles of epithelial-mesenchymal transition in squamous cell carcinoma of the temporal bone.
abstract: OBJECTIVE
  The authors recently demonstrated that extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone. The present objective was to investigate the expressions and the roles of epithelial-mesenchymal transition (EMT) in SCC of the temporal bone.
  
  
  METHODS
  Retrospective patient file review and immunohistochemical study of tissues of patients with SCC of the temporal bone.
  
  
  METHODS
  The authors examined the expressions of vimentin in 16 patients with SCC of the temporal bone by immunohistochemical analysis.
  
  
  RESULTS
  As expected, vimentin was expressed on SCC of the temporal bone. We regard the patient who has vimentin-positive cells as EMT-positive patient because gain of vimentin is a hallmark in the EMT reported in several types of cancer. EMT positive tumors significantly correlated with extensive bone erosion, and extensive bone erosion correlated with a worse prognosis of the SCC of the temporal bone.
  
  
  CONCLUSIONS
  The study results suggest that EMT in tumor cells becomes an important indicator of poor prognosis in SCC of the temporal bone.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Ito
authors.forename: Miyako
authors.initials: M
authors.lastname: Hatano
authors.forename: Satoru
authors.initials: S
authors.lastname: Kondo
authors.forename: Shioto
authors.initials: S
authors.lastname: Suzuki
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Yoshizaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000378:metabolism / Q000473:pathology*; D013701:Temporal Bone / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism
chemical_list: D014746:Vimentin