title: High entrapment efficiency of chitosan/polylactic acid/tripolyphotspate nanosized microcapsules for rapamycin by an emulsion-evaporation approach.
abstract: Chitosan (CS)/polylactic acid (PLA)/tripolyphotspate (TPP) nanosized microcapsules were prepared by emulsion-evaporation. The average diameter of the obtained nanosized microcapsules was around 100-300 nm, and a homogeneous size distribution and good dispersion were observed. The entrapment efficiency of the nanosized CS/PLA/TPP microcapsules for rapamycin was increased with the increase in amount of PLA. When the ratio of CS to PLA was 80 to 20, the entrapment efficiency of CS/PLA/TPP nanosized microcapsules for rapamycin reached the highest (89.8 +/- 1.72%). It was also observed that The RAPA entrapment efficiency reached its highest at 20% of addition dosage of RAPA.
authors.affiliation: Department of Public Health, Southeast, Nanjing 210096, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Fu
authors.forename: Daxin
authors.initials: D
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Wenjing
authors.initials: W
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Shiguang
authors.initials: S
authors.lastname: Jin
authors.forename: Nongyue
authors.initials: N
authors.lastname: He
mesh_terms: D002214:Capsules / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D004655:Emulsions / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D011122:Polyphosphates / Q000737:chemistry*; D020123:Sirolimus / Q000008:administration & dosage / Q000737:chemistry*; D014835:Volatilization
chemical_list: D002214:Capsules; D004655:Emulsions; D053769:Nanocapsules; D011091:Polyesters; D011108:Polymers; D011122:Polyphosphates; D019344:Lactic Acid; C033616:poly(lactide); D048271:Chitosan; C005692:triphosphoric acid; D020123:Sirolimus