title: Impact of conjugated linoleic acid on bone physiology: proposed mechanism involving inhibition of adipogenesis.
abstract: Conjugated linoleic acid (CLA) supplementation decreases adipose mass and increases bone mass in mice. Recent clinical studies demonstrate a beneficial effect of CLA on reducing weight and adipose mass in humans. This article reviews possible biological mechanisms of action of CLA on bone metabolism, focusing on modulation of nuclear receptor peroxisome proliferator-activated receptor gamma activity to steer mesenchymal stem cell differentiation toward an adipose and away from an osteoblast lineage. Clinical studies of the effects of CLA on bone mass and clinical implications of the effects of CLA on bone health in humans are summarized and discussed.
authors.affiliation: Division of Endocrinology, Diabetes, & Metabolism, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio 43210-1296, USA. steven.ing@osumc.edu
authors.forename: Steven W
authors.initials: SW
authors.lastname: Ing
authors.forename: Martha A
authors.initials: MA
authors.lastname: Belury
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D050156:Adipogenesis / Q000187:drug effects*; D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D002454:Cell Differentiation; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology*; D051379:Mice; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects / Q000378:metabolism
chemical_list: D052242:Adiponectin; D044243:Linoleic Acids, Conjugated; D047495:PPAR gamma; D018160:Receptors, Cytoplasmic and Nuclear