title: Prevalence and clinical associations of CXCR4-using HIV-1 among treatment-naive subtype C-infected women in Botswana.
abstract: HIV-1 coreceptor use was determined using a phenotypic assay in plasma samples from treatment-naive women infected with subtype C virus who had CD4 cell counts below 200 cells/mm3. Of 148 women, 14.9% were infected with dual/mixed virus; the remainder had R5 virus. A greater proportion of women in the lowest CD4 cell count stratum had dual/mixed virus (P = 0.026); change in coreceptor use after antiretroviral therapy exposure was uncommon. CXCR4-using HIV-1 was less common in subtype C-infected women than reported in subtype B cohorts but was most prevalent in women with the lowest CD4 cell counts.
authors.affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Nina H
authors.initials: NH
authors.lastname: Lin
authors.forename: Laura M
authors.initials: LM
authors.lastname: Smeaton
authors.forename: Françoise
authors.initials: F
authors.lastname: Giguel
authors.forename: Vladimir
authors.initials: V
authors.lastname: Novitsky
authors.forename: Sikhulile
authors.initials: S
authors.lastname: Moyo
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Mitchell
authors.forename: Joseph
authors.initials: J
authors.lastname: Makhema
authors.forename: Myron
authors.initials: M
authors.lastname: Essex
authors.forename: Shahin
authors.initials: S
authors.lastname: Lockman
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Kuritzkes
mesh_terms: D000328:Adult; D001902:Botswana / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood; D019718:Receptors, CXCR4 / Q000097:blood / Q000276:immunology*
chemical_list: C527276:CXCR4 protein, human; D012367:RNA, Viral; D019718:Receptors, CXCR4