title: Planar triazinium cations from VO(2+)-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA.
abstract: Planar triazinium cationic species, from VO(2+)-assisted cyclization of 1-(2-thiazolylazo)-2-naphthol, shows efficient DNA intercalative binding, visible light-induced anaerobic plasmid DNA photocleavage activity and photocytotoxicity in HeLa and MCF-7 cancer cells by an apoptotic pathway with selective localization of the compound in the nucleus as evidenced from the nuclear staining and confocal imaging.
authors.affiliation: Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India.
authors.forename: Puja
authors.initials: P
authors.lastname: Prasad
authors.forename: Imran
authors.initials: I
authors.lastname: Khan
authors.forename: Pijus K
authors.initials: PK
authors.lastname: Sasmal
authors.forename: Debasis
authors.initials: D
authors.lastname: Koley
authors.forename: Paturu
authors.initials: P
authors.lastname: Kondaiah
authors.forename: Akhil R
authors.initials: AR
authors.lastname: Chakravarty
mesh_terms: D001391:Azo Compounds / Q000737:chemistry / Q000494:pharmacology; D002412:Cations; D018360:Crystallography, X-Ray; D003500:Cyclization; D004247:DNA / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*; D014227:Triazines / Q000737:chemistry*; D017968:Vanadium Compounds / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D002412:Cations; D013844:Thiazoles; D014227:Triazines; D017968:Vanadium Compounds; C054556:1-(2-thiazolylazo)-2-naphthol; D004247:DNA