title: [Proportion of intermediate epithelial cells and human prostate cancer].
abstract: OBJECTIVE
  To study the different proportions of intermediate epithelial cells in human prostate cancer tissue and their clinical significance.
  
  
  METHODS
  We performed immunohistochemical staining for Cytokeratin 5 (CK5) and Cytokeratin 8 (CK8) on 60 samples of human prostate cancer, determined the proportions of intermediate epithelial cells in the cancer tissue, and classified the samples into 2 types, one with a majority of intermediate epithelial cells (CaP-INT, n = 32), and the other composed mostly of luminal epithelial cells (CaP-LUM, n = 28). Then we compared the 2 types of prostate cancer in the expression of the androgen receptor (AR), age of the patient, serum t-PSA, prostate volume, Gleason score, clinical stage, androgen resistance, and incidence of distant metastasis.
  
  
  RESULTS
  CaP-INT showed a significantly lower expression of AR ([24.42 +/- 11.41] %) and a higher incidence of distant metastasis (n = 14) than CaP-LUM ([77.21 +/- 10.22] % and n = 4) (P < 0.05). In the CaP-INT group, 6 of the 26 endocrinologically treated cases developed into androgen-independent prostate cancer (AIPC), while in the CaP-LUM group, only 1 out of 23 (P < 0.05). The former also showed remarkably higher clinical stages than the latter (P < 0.05), but no significant differences were found in age, serum t-PSA, prostate volume and Gleason score between the two groups (P > 0.05).
  
  
  CONCLUSIONS
  A higher proportion of intermediate epithelial cells may lead to increased invasiveness and metastasis of human prostate cancer.
authors.affiliation: Department of Urology, The First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200080, China.
authors.forename: Dian-Jun
authors.initials: DJ
authors.lastname: Yu
authors.forename: Yue-Qing
authors.initials: YQ
authors.lastname: Tang
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Shi
authors.forename: Yong-Chuan
authors.initials: YC
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhuo
authors.forename: Yi-Yong
authors.initials: YY
authors.lastname: Zhu
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Sun
authors.forename: Shu-Jie
authors.initials: SJ
authors.lastname: Xia
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000145:classification / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D011944:Receptors, Androgen / Q000378:metabolism
chemical_list: D011944:Receptors, Androgen