title: Significance of myofibroblasts in oral squamous cell carcinoma.
abstract: It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are α-smooth muscle actin-positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis.
authors.affiliation: School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Christenze
authors.initials: C
authors.lastname: Thode
authors.forename: Trine G
authors.initials: TG
authors.lastname: Jørgensen
authors.forename: Erik
authors.initials: E
authors.lastname: Dabelsteen
authors.forename: Ian
authors.initials: I
authors.lastname: Mackenzie
authors.forename: Sally
authors.initials: S
authors.lastname: Dabelsteen
mesh_terms: D000199:Actins / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D018925:Chemokines / Q000032:analysis; D018450:Disease Progression; D042783:Endothelial Cells / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000032:analysis; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D009062:Mouth Neoplasms / Q000473:pathology*; D058628:Myofibroblasts / Q000502:physiology*; D011379:Prognosis; D017154:Stromal Cells / Q000502:physiology; D059016:Tumor Microenvironment / Q000502:physiology
chemical_list: D000199:Actins; D018925:Chemokines; D016326:Extracellular Matrix Proteins