title: [In vitro pharmacodynamics study of an anti-HIV Chinese herbal formulation].
abstract: AIDS caused by HIV-1, is a major threat to human being. An anti-HIV formulation from Chinese herbs, so called "Qu Du Zeng Ning", have been recently developed. In this work, the pharmacodynamics of the formulation in vitro was studied. The results showed that Qu Du Zeng Ning inhibit the replication of HIV-1 efficiently in all cell-based assay, with IC50 at 105.2, 70.7, 77.4 microg mL(-1), separately. A significant synergy between the formulation and zidovudine (AZT) was observed, and it also showed a potent activity against HIV-1 drug-resistant mutant.
authors.affiliation: Beijing Century Health Pharmaceutical Technology Development Co., Ltd., Beijing 100021, China. zl_li@hotmail.com
authors.forename: Ze-lin
authors.initials: ZL
authors.lastname: Li
authors.forename: Yue
authors.initials: Y
authors.lastname: Zeng
authors.forename: Li-shan
authors.initials: LS
authors.lastname: Su
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Yi-ming
authors.initials: YM
authors.lastname: Shao
authors.forename: Xin
authors.initials: X
authors.lastname: Zeng
authors.forename: Hans
authors.initials: H
authors.lastname: Wolf
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured / Q000821:virology; D004338:Drug Combinations; D024882:Drug Resistance, Viral; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D017320:HIV Protease Inhibitors / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D020128:Inhibitory Concentration 50; D010946:Plants, Medicinal / Q000737:chemistry; D031363:Scutellaria / Q000737:chemistry; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D017320:HIV Protease Inhibitors; D015215:Zidovudine