title: 5-HT(3) receptors: potential of individual isoforms for personalised therapy.
abstract: Serotonin type 3 (5-HT(3)) receptors are ligand-gated ion channels built by five subunits of diverse composition. In humans, five subunits exist (5-HT3A-E) which are encoded by the genes HTR3A-E and are expressed in various isoforms. Recently, the importance of factors influencing receptor expression became clear, such as chaperones and microRNAs. Owing to their expression profile and physiological functions, 5-HT(3) receptors have been implicated in irritable bowel syndrome (IBS) and psychiatric disorders. Interestingly, HTR3 variants have now been shown to be associated with these conditions. This underlines the potential of 5-HT(3) receptors as therapeutic targets and may enable personalised therapies in the future.
authors.affiliation: Institute of Human Genetics, Department of Human Molecular Genetics, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany. beate.niesler@med.uni-heidelberg.de
authors.forename: Beate
authors.initials: B
authors.lastname: Niesler
mesh_terms: D006801:Humans; D043183:Irritable Bowel Syndrome / Q000188:drug therapy / Q000378:metabolism; D001523:Mental Disorders / Q000188:drug therapy / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D057285:Precision Medicine / Q000379:methods*; D020033:Protein Isoforms; D044406:Receptors, Serotonin, 5-HT3 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D018832:Molecular Chaperones; D020033:Protein Isoforms; D044406:Receptors, Serotonin, 5-HT3