title: Two cases of unexpected long-term improvement of Parkinson's disease after subthalamic nucleus deep brain stimulation removal.
abstract: Two patients with Parkinson's disease (PD) treated successfully with subthalamic nucleus deep brain stimulation (STN-DBS) for 3-4 years are reported, who demonstrated a persistent improvement following removal of STN-DBS for late infection. Possible hypotheses are discussed--whether a microlesioning effect or a disease-modifying effect of STN-DBS, though neither adequately explain this phenomenon.
authors.affiliation: Departments of Neurology, The Walton Centre, Liverpool, UK. suiwong@doctors.org.uk
authors.forename: S H
authors.initials: SH
authors.lastname: Wong
authors.forename: P R
authors.initials: PR
authors.lastname: Eldridge
authors.forename: A
authors.initials: A
authors.lastname: Duffy
authors.forename: S H
authors.initials: SH
authors.lastname: Fox
authors.forename: T R K
authors.initials: TR
authors.lastname: Varma
authors.forename: N A
authors.initials: NA
authors.lastname: Fletcher
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D046690:Deep Brain Stimulation / Q000379:methods*; D020878:Device Removal; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa