title: Peritoneal dialysis research in the UK: the Cardiff contribution.
abstract: The hallmark of the Cardiff contribution to our understanding of peritoneal dialysis over the past quarter century has been their translational approach to research, combining strong basic science with intelligent clinical questions. Their themes have included describing the biology of the dialyzed membrane; elucidation of several overlapping mechanisms of bioincompatibility, resulting in the development and testing of more biocompatible solutions; and describing the morphological changes with time on treatment and the membrane's response to infection. This has extended to investigation of the mechanisms controlling initiation and resolution by the innate immune system, relevant to both long-term membrane injury and a wider understanding of immunobiology. More than any other group, they have held the torch for basic science in peritoneal dialysis research.
authors.affiliation: Department of Nephrology, University Hospital of North Staffordshire, Stoke-on-Trent, Staffordshire, United Kingdom. simondavies1@compuserve.com
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Davies
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001695:Biology; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D015314:Dialysis Solutions / Q000737:chemistry; D006801:Humans; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000473:pathology / Q000502:physiology; D010538:Peritonitis / Q000276:immunology; D012042:Registries; D012106:Research; D014852:Wales
chemical_list: D001672:Biocompatible Materials; D015415:Biomarkers; D015314:Dialysis Solutions