title: F-18 FDG PET-CT in patients with recurrent glioma: comparison with contrast enhanced MRI.
abstract: OBJECTIVE
  The purpose of the study was to compare the efficacies of FDG PET-CT and contrast enhanced MRI in detection of recurrent gliomas.
  
  
  METHODS
  Ninety histopathologically proven glioma patients with clinical suspicion of recurrence were evaluated. All patients underwent FDG PET-CT scan and contrast enhanced MRI. Combination of clinical follow up, repeat imaging and biopsy (when available) was taken as gold standard.
  
  
  RESULTS
  Based on gold standard criteria, 59 patients were positive and 31 patients were negative for recurrence. Overall sensitivity and specificity of FDG PET-CT were 70% and 97% respectively whereas that for contrast enhanced MRI was 95% and 23%. FDG PET-CT also has higher accuracy (80%) as compared to MRI (70%). FGD PET-CT has lower sensitivity than MRI in all grades, except for Grade II gliomas where their sensitivities are comparable (95% and 90%). Very low specificity of MRI was observed in all grades of tumour (18-33%). In contrast the specificity of FDG PET-CT was high across all grades (83-100%).
  
  
  CONCLUSIONS
  FDG PET-CT is a highly specific modality for detecting recurrence in patients with gliomas and can effectively exclude post therapy changes.
authors.affiliation: Department of Nuclear Medicine, Medical College Kolkata, Kolkata, India. a_ranjan_santra@yahoo.co.in
authors.forename: Amburanjan
authors.initials: A
authors.lastname: Santra
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Punit
authors.initials: P
authors.lastname: Sharma
authors.forename: Chandrashekhar
authors.initials: C
authors.lastname: Bal
authors.forename: Atin
authors.initials: A
authors.lastname: Kumar
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Julka
authors.forename: Arun
authors.initials: A
authors.lastname: Malhotra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002648:Child; D003287:Contrast Media; D005260:Female; D019788:Fluorodeoxyglucose F18; D005910:Glioma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18