title: Antimelanogenic and antioxidative properties of Bifidobacterium bifidum.
abstract: Various skin hyperpigmentation disorders consist in accumulation and overproduction of melanin. In this report, we investigated the melanogenesis inhibitory and antioxidant effects of Bifidobacterium bifidum culture filtrate. The results revealed that B. bifidum culture filtrate effectively suppresses murine tyrosinase activity and decreases the amount of intracellular melanin in a dose-dependent manner. Additionally, the bacterial culture filtrate-scavenged DPPH and ABTS radicals, and shows potent-reducing power in a dose-dependent pattern. Our results expand the application of B. bifidum culture filtrate in the development and research of skin-whitening ingredients.
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, ROC.
authors.forename: Huey-Chun
authors.initials: HC
authors.lastname: Huang
authors.forename: Wen-Ying
authors.initials: WY
authors.lastname: Huang
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Chiu
authors.forename: Hui-Ju
authors.initials: HJ
authors.lastname: Ke
authors.forename: Shu-Wen
authors.initials: SW
authors.lastname: Chiu
authors.forename: Sze-Yun
authors.initials: SY
authors.lastname: Wu
authors.forename: Feng-Sheng
authors.initials: FS
authors.lastname: Kuo
authors.forename: Tsong-Min
authors.initials: TM
authors.lastname: Chang
mesh_terms: D000363:Agaricales; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D052160:Benzothiazoles / Q000378:metabolism; D001644:Bifidobacterium / Q000254:growth & development / Q000378:metabolism*; D001713:Biphenyl Compounds / Q000378:metabolism; D002478:Cells, Cultured; D002642:Chick Embryo; D017077:Culture Media, Conditioned / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D005656:Fungal Proteins / Q000037:antagonists & inhibitors*; D017495:Hyperpigmentation / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D008543:Melanins / Q000378:metabolism*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010851:Picrates / Q000378:metabolism; D013451:Sulfonic Acids / Q000378:metabolism
chemical_list: D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D017077:Culture Media, Conditioned; D005656:Fungal Proteins; D008543:Melanins; D010851:Picrates; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D014442:Monophenol Monooxygenase