title: [Neurodegenerative conformational disease and heat shock proteins].
abstract: Many major neurodegenerative diseases are associated with proteins misfolding and aggregation, which are also called "neurodegenerative conformational disease". The interaction of gene mutation and environmental factors are probably primary events resulting in oligomer and aggregate formations of proteins. Moreover, the dysfunctions of protein control systems, i.e. the ubiquitin-proteasome system and autophagy-lysosomal system, also contribute to the neurodegenerative process. The present review mainly summarizes protein misfolding and aggregation in the development of neurodegenerative conformational disease and the underling mechanisms, as well as upregulation of heatshock proteins as a promising treatment method for this kind of disease.
authors.affiliation: Institute ofMateria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. kxc1981@yeah.net
authors.forename: Xiang-Chen
authors.initials: XC
authors.lastname: Kong
authors.forename: Xiu-Qi
authors.initials: XQ
authors.lastname: Bao
authors.forename: Geng-Tao
authors.initials: GT
authors.lastname: Liu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000818:Animals; D031041:Annona / Q000737:chemistry; D001343:Autophagy; D044482:Benzeneacetamides / Q000302:isolation & purification / Q000627:therapeutic use; D006360:Heat-Shock Proteins / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D010636:Phenols / Q000302:isolation & purification / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D017510:Protein Folding; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D044482:Benzeneacetamides; D006360:Heat-Shock Proteins; D010636:Phenols; D025801:Ubiquitin; C084439:squamosamide; D046988:Proteasome Endopeptidase Complex