title: [Sacral neuromodulation with InterStim™ system: Results from the French national register].
abstract: OBJECTIVE
  To analyse current practice patterns and to evaluate (long-term) effectiveness and adverse events of sacral neuromodulation with InterStim™ Therapy based on data collected in a national register and to discuss the strengths and weaknesses of the register.
  
  
  METHODS
  This is a French multicenter prospective observational trial including patients with a permanent implant (2003-2009). Voiding diary variables and patient satisfaction were analysed based on last follow-up visit since implantation.
  
  
  RESULTS
  One thousand four hundred and eighteen patients (median age: 63 years, 1206 females) were included in the database (median follow-up: 12 months). One thousand and eighty-nine patients had non-neurological disease. The principal diagnosis was overactive bladder syndrome ([OAB], n=1170) and retention (n=151). Implantation occurred in 1358 patients; 1172 patients had greater than or equal to one registered follow-up. Clinical improvement of greater than or equal to 50% was seen in 447/527 patients with OAB at 12 months follow-up (median number of voids per 24 hours decreased from 15 at baseline to 8 at 12 months) and in 42/54 of patients with retention (median number of catheterization per 24 hours dropped from 5 at baseline to 0 at 12 months). Clinical improvement remained relatively stable up to 60 months. Median patient satisfaction with treatment was between 60 and 80%. Five hundred and twenty-four patients had at least one adverse event; loss of efficacy (n=244) occurred most frequently.
  
  
  CONCLUSIONS
  In this large database sacral neuromodulation with InterStim™ Therapy seems to be an effective treatment through routine practice in the long-term (up to 60 months) for patients refractory to medical treatment.
authors.affiliation: Service d'urologie, groupe hospitalier Pitié-Salpêtrière, Paris-VI, 83, boulevard de l'Hôpital, 75013 Paris, France. emmanuel.chartier-kastler@psl.aphp.fr
authors.forename: E
authors.initials: E
authors.lastname: Chartier-Kastler
authors.forename: P
authors.initials: P
authors.lastname: Ballanger
authors.forename: M
authors.initials: M
authors.lastname: Belas
authors.forename: J
authors.initials: J
authors.lastname: Biserte
authors.forename: L
authors.initials: L
authors.lastname: Corbel
authors.forename: X
authors.initials: X
authors.lastname: Gamé
authors.forename: P
authors.initials: P
authors.lastname: Grise
authors.forename: G
authors.initials: G
authors.lastname: Karsenty
authors.forename: L
authors.initials: L
authors.lastname: Le Normand
authors.forename: B
authors.initials: B
authors.lastname: Mauroy
authors.forename: J
authors.initials: J
authors.lastname: Pasquale
authors.forename: A
authors.initials: A
authors.lastname: Ruffion
authors.forename: T
authors.initials: T
authors.lastname: Rousseau
authors.forename: C
authors.initials: C
authors.lastname: Saussine
authors.forename: M
authors.initials: M
authors.lastname: Suberville
authors.forename: C
authors.initials: C
authors.lastname: Tollon
mesh_terms: D004599:Electric Stimulation Therapy; D005260:Female; D005602:France; D006801:Humans; D008160:Lumbosacral Plexus; D008297:Male; D011446:Prospective Studies; D012042:Registries; D014549:Urinary Incontinence / Q000628:therapy*