title: Reduction of Alzheimer's disease amyloid-β in plasma by hemodialysis and its relation to cognitive functions.
abstract: OBJECTIVE
  Rapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer's disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states.
  
  
  METHODS
  Aβ concentrations and Mini-Mental State Examinations (MMSE) were investigated in 37 hemodialysis patients (68.9 ± 4.1 years).
  
  
  RESULTS
  The dialyzers effectively removed Aβ(1-40) and Aβ(1-42), 63.9 ± 14.4 and 51.6 ± 17.0% at 4 h dialysis, resulting in the reduction of Aβs in whole-body circulation by 51.1 ± 8.9 and 32.7 ± 12.0%, respectively. Although the plasma Aβs before dialysis (750.8 ± 171.3 pg/ml for Aβ(1-40)) were higher than those reported for Alzheimer's disease patients, the cognitive states of hemodialysis patients were relatively normal, especially of longer dialysis vintages.
  
  
  CONCLUSIONS
  Dialyzers effectively reduced Aβs in whole-body circulation. Repeated rapid decrease of plasma Aβs might maintain cognitive state.
authors.affiliation: Faculty of Clinical Engineering Technology, School of Health Sciences, Fujita Health University, Kutsukake-cho, Toyoake, Japan. nkitaguc@fujita-hu.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Kitaguchi
authors.forename: K
authors.initials: K
authors.lastname: Kawaguchi
authors.forename: S
authors.initials: S
authors.lastname: Nakai
authors.forename: K
authors.initials: K
authors.lastname: Murakami
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Hoshino
authors.forename: H
authors.initials: H
authors.lastname: Hori
authors.forename: A
authors.initials: A
authors.lastname: Ohashi
authors.forename: Y
authors.initials: Y
authors.lastname: Shimano
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Yuzawa
authors.forename: T
authors.initials: T
authors.lastname: Mutoh
authors.forename: S
authors.initials: S
authors.lastname: Sugiyama
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000473:pathology / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000097:blood* / Q000302:isolation & purification; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D003071:Cognition; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000097:blood* / Q000302:isolation & purification; D006435:Renal Dialysis / Q000706:statistics & numerical data*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)