title: Effects of intramuscular parecoxib administration on vasospasm in an experimental subarachnoid hemorrhage model.
abstract: OBJECTIVE
  We examined whether intramuscular parecoxib administration has a preventive or therapeutic effect on vasospasm following experimental subarachnoid hemorrhage (SAH).
  
  
  METHODS
  Twenty New Zealand White Rabbits were assigned randomly to one of four groups. Animals in Group I were not subjected to SAH (control group). Animals in all other groups were subjected to SAH. Animals in Group II received no treatment after SAH induction (SAH group). Animals in Group III received intramuscular parecoxib (diluted with saline) injection at 6 and at 30 hours after SAH (treatment group). Animals in Group IV received only intramuscular saline injection at 6 and at 30 hours after SAH (vehicle group). Animals were euthanized by perfusion and fixation 48 hours after SAH induction. Basilar artery cross-sectional areas and wall thicknesses were measured. Statistical comparisons were performed using Kruskal-Wallis and Mann-Whitney U tests.
  
  
  RESULTS
  Basilar artery cross-sectional areas in the treatment group were significantly higher than in the SAH or vehicle group (p<.05). Basilar artery wall thickness in the treatment group was significantly smaller than in the SAH or vehicle group (p<.05).
  
  
  CONCLUSIONS
  Our study revealed that intramuscular administration of parecoxib significantly attenuates vasospasm following experimental SAH.
authors.affiliation: Department of Neurosurgery, Hacettepe University School of Medicine, Ankara, Turkey. ozgur.celik@ymail.com
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Çelik
authors.forename: Burçak
authors.initials: B
authors.lastname: Bilginer
authors.forename: Adnan
authors.initials: A
authors.lastname: Korkmaz
authors.forename: Pınar Naile
authors.initials: PN
authors.lastname: Gürgör
authors.forename: Murad
authors.initials: M
authors.lastname: Bavbek
authors.forename: Tunçalp
authors.initials: T
authors.lastname: Özgen
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Ziyal
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology; D004195:Disease Models, Animal; D007273:Injections, Intramuscular; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000503:physiopathology*; D020301:Vasospasm, Intracranial / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*
chemical_list: D000893:Anti-Inflammatory Agents; D052246:Cyclooxygenase 2 Inhibitors; D007555:Isoxazoles; C409945:parecoxib