title: Virus detection and duration of illness among patients with 2009 pandemic influenza A (H1N1) virus infection in Texas.
abstract: Knowledge from early outbreaks is limited regarding the virus detection and illness duration of the 2009 pandemic influenza A (H1N1) infections. During the period from April to May 2009 in Texas, we collected serial nasopharyngeal (NP) and stool specimens from 35 participants, testing by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) and culture. The participants were aged 2 months to 71 years; 25 (71%) were under 18. The median duration of measured fever was 3.0 days and of virus detection in NP specimens was 4.2 days; however, few specimens were collected between days 5-9. The duration of virus detection (4.2 days) was similar to the duration of fever (3.5 days) (RR, 1.14; 95% CI, .66-1.95; P = .8), but was shorter than the duration of cough (11.0 days) (RR, .41; 95% CI, .24-.68; P < .001). We detected viral RNA in two participants' stools. All cultures were negative. This investigation suggests that the duration of virus detection was likely similar to the seasonal influenza virus.
authors.affiliation: Epidemic Intelligence Service, Scientific Education and Professional Development Program Office (Proposed), Centers for Disease Control and Prevention, Atlanta, Georgia, USA. asuryaprasad@cdc.gov
authors.forename: Anil
authors.initials: A
authors.lastname: Suryaprasad
authors.forename: Oliver W
authors.initials: OW
authors.lastname: Morgan
authors.forename: Patrick
authors.initials: P
authors.lastname: Peebles
authors.forename: Agnes
authors.initials: A
authors.lastname: Warner
authors.forename: Tara K
authors.initials: TK
authors.lastname: Kerin
authors.forename: Mathew D
authors.initials: MD
authors.lastname: Esona
authors.forename: Michael D
authors.initials: MD
authors.lastname: Bowen
authors.forename: Wendy
authors.initials: W
authors.lastname: Sessions
authors.forename: Xiyan
authors.initials: X
authors.lastname: Xu
authors.forename: Theresa
authors.initials: T
authors.lastname: Cromeans
authors.forename: Fatimah
authors.initials: F
authors.lastname: Dawood
authors.forename: Trudi
authors.initials: T
authors.lastname: Shim
authors.forename: Manoj
authors.initials: M
authors.lastname: Menon
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Verani
authors.forename: Dean
authors.initials: D
authors.lastname: Erdman
authors.forename: Stephen
authors.initials: S
authors.lastname: Lindstrom
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Fonseca
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Fry
authors.forename: Sonja J
authors.initials: SJ
authors.lastname: Olsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003371:Cough / Q000175:diagnosis; D005243:Feces / Q000821:virology; D005260:Female; D005334:Fever / Q000175:diagnosis; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000473:pathology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009305:Nasopharynx / Q000821:virology; D058873:Pandemics; D011247:Pregnancy; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013781:Texas; D013997:Time Factors; D014776:Virus Cultivation; D017201:Virus Shedding; D055815:Young Adult