title: Phosphoryl-EZH-ion.
abstract: Polycomb group (PcG) proteins regulate gene expression in embryonic and adult stem cells, but the mechanisms responsible for PcG gene targeting and regulation remain largely unknown. Recent evidence shows that EZH2, the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), is a nuclear phosphoprotein linking cell-cycle-intrinsic or extracellular signals to specific epigenetic signatures.
authors.affiliation: Department of Biomolecular Sciences and Biotechnology, University of Milan, 20133 Milan, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Caretti
authors.forename: Daniela
authors.initials: D
authors.lastname: Palacios
authors.forename: Vittorio
authors.initials: V
authors.lastname: Sartorelli
authors.forename: Pier Lorenzo
authors.initials: PL
authors.lastname: Puri
mesh_terms: D000818:Animals; D002453:Cell Cycle; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; D048049:Extracellular Signal-Regulated MAP Kinases