title: Selective and sensitive TNT sensors using biomimetic polydiacetylene-coated CNT-FETs.
abstract: Miniaturized smart sensors that can perform sensitive and selective real-time monitoring of target analytes are tremendously valuable for various sensing applications. We developed selective nanocoatings by combining trinitrotoluene (TNT) receptors bound to conjugated polydiacetylene (PDA) polymers with single-walled carbon nanotube field-effect transistors (SWNT-FET). Selective binding events between the TNT molecules and phage display derived TNT receptors were effectively transduced to sensitive SWNT-FET conductance sensors through the PDA coating layers. The resulting sensors exhibited an unprecedented 1 fM sensitivity toward TNT in real time, with excellent selectivity over various similar aromatic compounds. Our biomimetic receptor coating approach may be useful for the development of sensitive and selective micro- and nanoelectronic sensor devices for various other target analytes.
authors.affiliation: Department of Bioengineering, University of California, Berkeley, California 94720, USA.
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Kim
authors.forename: Byung Yang
authors.initials: BY
authors.lastname: Lee
authors.forename: Justyn
authors.initials: J
authors.lastname: Jaworski
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Woo-Jae
authors.initials: WJ
authors.lastname: Chung
authors.forename: Eddie
authors.initials: E
authors.lastname: Wang
authors.forename: Seunghun
authors.initials: S
authors.lastname: Hong
authors.forename: Arun
authors.initials: A
authors.lastname: Majumdar
authors.forename: Seung-Wuk
authors.initials: SW
authors.lastname: Lee
mesh_terms: D032701:Biomimetics; D057230:Limit of Detection; D018625:Microscopy, Atomic Force; D037742:Nanotubes, Carbon; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry*; D053279:Polyynes / Q000737:chemistry*; D014303:Trinitrotoluene / Q000032:analysis*
chemical_list: D037742:Nanotubes, Carbon; D000078789:Polyacetylene Polymer; D011108:Polymers; D014303:Trinitrotoluene; D053279:Polyynes; C082361:polydiacetylene