title: Graphical process design tools for iontophoretic transdermal drug-delivery devices.
abstract: A graphical procedure was proposed for the optimum design of transdermal drug-delivery systems enhanced by iontophoresis. Contour plots displayed the relationships among steady-state plasma level, current density and initial drug concentration in a vehicle. This information was combined with a closed-form expression of the process time constant, estimated as the medicament in the blood reaches a plateau after application of the electric field. Analysis was conducted using Laplace-transformed variables and did not require time-domain solutions. Simulation results show that a current density of 0.044 mA/cm(2) and a loading of 3500 μg/ml of dexamethasone sodium m-sulfobenzoate were necessary to achieve an equilibrium plasma concentration of 1.254 ng/cm(3) with a time constant of 8.34 h.
authors.affiliation: Otto H. York Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA. laurent.simon@njit.edu
authors.forename: Laurent
authors.initials: L
authors.lastname: Simon
mesh_terms: D000279:Administration, Cutaneous; D003196:Computer Graphics; D003198:Computer Simulation; D003907:Dexamethasone / Q000378:metabolism; D016503:Drug Delivery Systems; D006801:Humans; D007478:Iontophoresis / Q000379:methods*; D008490:Medical Informatics / Q000379:methods; D015233:Models, Statistical; D009369:Neoplasms / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption; D013997:Time Factors
chemical_list: D003907:Dexamethasone