title: Neonatal exposure to leptin reduces glucose tolerance in adult mice.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of leptin treatment in mouse neonates on glucose metabolism in adulthood.
  
  
  METHODS
  Leptin was administered subcutaneously to normally nourished neonates, from 5.5 to 10.5 days of age, to mimic the premature surge observed in neonates undernourished in utero. At 15-16 weeks of age, we measured blood glucose or insulin levels after the intraperitoneal administration of glucose or insulin.
  
  
  RESULTS
  After the intraperitoneal administration of glucose, the levels of blood glucose, but not insulin, in adult mice that received the neonatal leptin treatment were significantly higher than that of those which received vehicle control. After the intraperitoneal administration of insulin, the levels of blood glucose in adult mice that underwent neonatal leptin treatment were significantly higher than that of those which received vehicle control.
  
  
  CONCLUSIONS
  These findings suggest that the premature leptin surge plays an essential role, as a programming signal during the early neonatal period, as well as in the developmental origins of impaired insulin sensitivity.
authors.affiliation: Department of Gynecology and Obstetrics, Hamamatsu University School of Medicine, Japan. hitou-endo@umin.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Yura
authors.forename: N
authors.initials: N
authors.lastname: Sagawa
authors.forename: N
authors.initials: N
authors.lastname: Kanayama
authors.forename: I
authors.initials: I
authors.lastname: Konihi
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007263:Infusions, Parenteral; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000008:administration & dosage / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D008055:Lipids