title: A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye.
abstract: Previously we reported the novel observation that astrocytes ensheath the persistent hyaloid artery, both in the Nuc1 spontaneous mutant rat, and in human PFV (persistent fetal vasculature) disease (Developmental Dynamics 234:36-47, 2005). We now show that astrocytes isolated from both the optic nerve and retina of Nuc1 rats migrate faster than wild type astrocytes. Aquaporin 4 (AQP4), the major water channel in astrocytes, has been shown to be important in astrocyte migration. We demonstrate that AQP4 expression is elevated in the astrocytes in PFV conditions, and we hypothesize that this causes the cells to migrate abnormally into the vitreous where they ensheath the hyaloid artery. This abnormal association of astrocytes with the hyaloid artery may impede the normal macrophage-mediated remodeling and regression of the hyaloid system.
authors.affiliation: The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Laura
authors.initials: L
authors.lastname: Asnaghi
authors.forename: Celine
authors.initials: C
authors.lastname: Gongora
authors.forename: Bonnie
authors.initials: B
authors.lastname: Patek
authors.forename: Stacey
authors.initials: S
authors.lastname: Hose
authors.forename: Bo
authors.initials: B
authors.lastname: Ma
authors.forename: Masoud Aghsaei
authors.initials: MA
authors.lastname: Fard
authors.forename: Lawrence
authors.initials: L
authors.lastname: Brako
authors.forename: Kamaljeet
authors.initials: K
authors.lastname: Singh
authors.forename: Morton F
authors.initials: MF
authors.lastname: Goldberg
authors.forename: James T
authors.initials: JT
authors.lastname: Handa
authors.forename: Woo-Kuen
authors.initials: WK
authors.lastname: Lo
authors.forename: Charles G
authors.initials: CG
authors.lastname: Eberhart
authors.forename: J Samuel
authors.initials: JS
authors.lastname: Zigler
authors.forename: Debasish
authors.initials: D
authors.lastname: Sinha
mesh_terms: D000818:Animals; D051401:Aquaporin 4 / Q000235:genetics / Q000378:metabolism; D001253:Astrocytes / Q000166:cytology / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D005123:Eye / Q000098:blood supply*; D006801:Humans; D051379:Mice; D009900:Optic Nerve / Q000166:cytology / Q000378:metabolism; D054514:Persistent Hyperplastic Primary Vitreous / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism; D012160:Retina / Q000166:cytology / Q000378:metabolism
chemical_list: D051401:Aquaporin 4; D018160:Receptors, Cytoplasmic and Nuclear