title: [The crystalline polymorph control and selection of gabapentin with polymer heteronuclei].
abstract: The pharmaceutical properties, including the physical and chemical properties, and the bioavailability are greatly influenced by their polymorphism. In this paper the polymer heteronuclei were used to produce the gabapentin polymorphs that were characterized by X-ray powder diffraction, FT-IR and DSC. The results indicated that the polymer heteronuclei are an effective method to control and select the gabapentin polymorphism. One new polymorph of gabapentin was found besides all known gabapentin polymorphs.
authors.affiliation: Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.forename: Min-Liang
authors.initials: ML
authors.lastname: Ru
authors.forename: Mei-Dong
authors.initials: MD
authors.lastname: Lang
mesh_terms: D000588:Amines / Q000737:chemistry*; D000927:Anticonvulsants / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D003509:Cyclohexanecarboxylic Acids / Q000737:chemistry*; D000077206:Gabapentin; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D005680:gamma-Aminobutyric Acid / Q000737:chemistry*
chemical_list: D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D011108:Polymers; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin