title: Anti-inflammatory and antioxidant components from Hygroryza aristata.
abstract: Twenty-six known compounds and two new compounds, including a new lignan, (7S*,8R*,7'R*,8'S*)-icariol A₂-9-O-β-xylopyranoside (1), and a new indole alkaloid, hygarine (2), were isolated from the extracts of Hygroryza aristata (Gramineae). The structures of all compounds were elucidated on the basis of NMR spectral analysis. The compounds (-)-epigallocatechin-3-O-gallate (4) and (-)-epicatechin-3-O-gallate (5) possess free radical scavenging activities and compound 1 could inhibit superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils with IC₅₀ values of 19.33 ± 0.86 and 24.14 ± 1.59 μM, respectively.
authors.affiliation: Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Chung
authors.forename: Yu-Hsuan
authors.initials: YH
authors.lastname: Lan
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Yann-Lii
authors.initials: YL
authors.lastname: Leu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D006109:Poaceae / Q000737:chemistry*; D013481:Superoxides / Q000037:antagonists & inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D013481:Superoxides; D010196:Pancreatic Elastase