title: Comparison of classical surgery and sutureless repair with DuraSeal or fibrin glue for duodenal perforation in rats.
abstract: BACKGROUND
  The purpose of the study was to compare classical primary suture repair and sutureless repair with fibrin glue or DuraSeal adhesion barrier for the closure of duodenal perforation in rats.
  
  
  METHODS
  Forty adult female Wistar Albino rats weighing between 250-300 g were randomly divided into four equal groups. Primary repair, primary repair and omentoplasty, or application of fibrin glue or DuraSeal adhesion barrier was performed in each of the four groups, respectively. The bursting pressure, tissue hydroxyproline levels and histopathology were evaluated.
  
  
  RESULTS
  Bursting pressure values of the primary repair and primary repair and omentoplasty groups were significantly higher than in the fibrin glue and DuraSeal groups (p < 0.001). There were no significant differences between the experimental groups regarding hydroxyproline levels and histological parameters.
  
  
  CONCLUSIONS
  The sutureless methods (Fibrin glue, DuraSeal) have no superior effects when compared with the conventional repair techniques. We observed similar results between the sutureless repair groups; thus, DuraSeal can be considered an alternative to fibrin glue for this purpose. This suggestion must be supported with new studies, however, which would be planned with other wound healing markers and different designs.
authors.affiliation: Department of General Surgery, Istanbul University Cerrahpaşa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Saliha
authors.initials: S
authors.lastname: Karagöz Avci
authors.forename: Serdar
authors.initials: S
authors.lastname: Yüceyar
authors.forename: Erman
authors.initials: E
authors.lastname: Aytaç
authors.forename: Onur
authors.initials: O
authors.lastname: Bayraktar
authors.forename: Ilknur
authors.initials: I
authors.lastname: Erenler
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ustün
authors.forename: Hafize
authors.initials: H
authors.lastname: Uzun
authors.forename: Süphan
authors.initials: S
authors.lastname: Ertürk
mesh_terms: D000818:Animals; D004378:Duodenal Diseases / Q000601:surgery*; D005260:Female; D015718:Fibrin Tissue Adhesive; D007416:Intestinal Perforation / Q000601:surgery*; D009852:Omentum / Q000601:surgery; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012117:Resins, Synthetic; D014014:Tissue Adhesives
chemical_list: D015718:Fibrin Tissue Adhesive; D012117:Resins, Synthetic; D014014:Tissue Adhesives; C030189:Dura-Seal