title: A meta-analysis on treatment effects of thiazolidinediones for type 2 diabetes mellitus in Asian populations.
abstract: OBJECTIVE
  to assess the effects of thiazolidinediones (pioglitazone and rosiglitazone) in the treatment of T2DM in Asian population.
  
  
  METHODS
  randomized controlled trials of T2DM patients in Asian population that compared pioglitazone or rosiglitazone with other treatments for more than 3 months and reported HbA1c data were included. Analyses for all outcomes were calculated using random effect model.
  
  
  RESULTS
  the analyses included 37 studies in approximately 3,000 patients. Thiazolidinediones had beneficial effect on HbA1c (glycosylated hemoglobin/hemoglobin A1c) compared with control (weighted mean difference (WMD) -0.12%; 95% CI [confidence interval], -0.54 to -0.19% for pioglitazone and -0.47%; 95% CI, -0.89 to -0.40% for rosiglitazone). Overall, TZDs showed significant benefit on glycemic outcomes measured by HbA1c as main surrogate outcome compared with previous glycemic control but not with other anti-diabetics.
  
  
  CONCLUSIONS
  thiazolidinediones treatment resulted in favorable effects on glycemic control in Asian patients with T2DM. Long-term efficacy and safety data of TZD could not yet be confirmed due to the lack of randomized studies with patient-oriented outcomes.
authors.affiliation: Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Indonesia, Jl. Salemba 6 Jakarta Pusat 10430, Indonesia. melva.louisa@gmail.com
authors.forename: Melva
authors.initials: M
authors.lastname: Louisa
authors.forename: Madoka
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takeuchi
authors.lastname: Nafrialdi
authors.forename: Rianto
authors.initials: R
authors.lastname: Setiabudy
mesh_terms: D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016001:Confidence Intervals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007564:Japan / Q000453:epidemiology; D008297:Male; D000077205:Pioglitazone; D015995:Prevalence; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D000077205:Pioglitazone; D000077154:Rosiglitazone; D045162:Thiazolidinediones