title: The effect of female hormones upon urate transport systems in the mouse kidney.
abstract: Increased levels of serum urate in postmenopausal women are thought to be caused by a change in renal urate elimination associated with the loss of female hormones. In this study, we investigated the regulation of renal urate transporter expression by female hormones using ovariectomized mice with or without hormone replacement. Estradiol suppressed the protein levels of urate reabsorptive transporters urate transporter 1 and glucose transporter 9 (Urat1 and Glut9), and that of urate efflux transporter ATP-binding cassette sub-family G member 2 (Abcg2). Progesterone suppressed protein levels of sodium-coupled monocarboxylate transporter 1 (Smct1). However, neither estradiol nor progesterone influenced the respective levels of mRNA.
authors.affiliation: Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takiue
authors.forename: Makoto
authors.initials: M
authors.lastname: Hosoyamada
authors.forename: Masaki
authors.initials: M
authors.lastname: Kimura
authors.forename: Hidetsugu
authors.initials: H
authors.lastname: Saito
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000818:Animals; D027682:Cation Transport Proteins / Q000235:genetics; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D027501:Monocarboxylic Acid Transporters; D027361:Organic Anion Transporters / Q000235:genetics; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism*
chemical_list: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; C501412:Abcg2 protein, mouse; D027682:Cation Transport Proteins; D051246:Glucose Transport Proteins, Facilitative; D027501:Monocarboxylic Acid Transporters; D027361:Organic Anion Transporters; D012333:RNA, Messenger; C109687:Slc22a12 protein, mouse; C498775:Slc2a9 protein, mouse; C507459:Slc5a8 protein, mouse; D014527:Uric Acid; D011374:Progesterone; D004958:Estradiol