title: Confirmed local endemicity and putative high transmission of Schistosoma mansoni in the Sesse Islands, Lake Victoria, Uganda.
abstract: The Sesse Islands, in the Ugandan portion of Lake Victoria, have long been considered a low transmission zone for intestinal schistosomiasis. Based on observations of high prevalence of Schistosoma mansoni infection in the northern-most islands of this archipelago, a follow-up survey was conducted to ascertain whether transmission was endemic to this island group, combining parasitological and malacological surveys. Prevalence of intestinal schistosomiasis was again observed to be high, as was intensity of infections which, combined with low reported incidence of treatment, suggests that chemotherapy-based control initiatives are not being maximally effective in this region as high levels of population movement between islands and districts are confounding. The local disease transmission was confirmed by the observations of high abundance of Biomphalaria, as well as field-caught snails shedding S. mansoni cercariae. DNA sequencing of 12 cercariae revealed common mitochondrial cox1 haplotypes, as well as, novel ones, consistent with the high genetic diversity of this parasite in Lake Victoria. Intestinal schistosomiasis is firmly endemic in parts of the Sesse Islands and more broadly, this island group provides an insight into the future challenges to be faced by the Ugandan National Control Programme in regularly reaching these rather remote, inaccessible and largely itinerant communities.
authors.affiliation: Wolfson Wellcome Biomedical Laboratory, Department of Zoology, Natural History Museum, London, SW7 5BD, UK.
authors.forename: Claire J
authors.initials: CJ
authors.lastname: Standley
authors.forename: Moses
authors.initials: M
authors.lastname: Adriko
authors.forename: Fred
authors.initials: F
authors.lastname: Besigye
authors.forename: Narcis B
authors.initials: NB
authors.lastname: Kabatereine
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Stothard
mesh_terms: D000293:Adolescent; D000818:Animals; D001700:Biomphalaria / Q000469:parasitology*; D002648:Child; D016000:Cluster Analysis; D051545:Cyclooxygenase 1 / Q000235:genetics; D019353:Endemic Diseases; D014644:Genetic Variation; D005843:Geography; D006239:Haplotypes; D015801:Helminth Proteins / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D015995:Prevalence; D012550:Schistosoma mansoni / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D012555:Schistosomiasis mansoni / Q000453:epidemiology* / Q000635:transmission*; D017422:Sequence Analysis, DNA; D014454:Uganda / Q000453:epidemiology
chemical_list: D015801:Helminth Proteins; D051545:Cyclooxygenase 1