title: Pressure-driven DNA in nanogroove arrays: complex dynamics leads to length- and topology-dependent separation.
abstract: The motion of linear and circular DNA molecules is studied under pressure driven buffer flow in a 50 nm slit channel with arrays of transverse 150 nm deep nanogrooves. Transport occurs through two states of propagation unique to this nanogroove geometry, a slow, stepwise groove-to-groove translation called the "sidewinder" and a fast, continuous tumbling across the grooves called the "tumbleweed". Dynamical transitions between the two states are observed at fixed buffer velocity. Molecules exhibit size- and topology-dependent velocities.
authors.affiliation: DTU Nanotech, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
authors.forename: Morten Bo
authors.initials: MB
authors.lastname: Mikkelsen
authors.forename: Walter
authors.initials: W
authors.lastname: Reisner
authors.forename: Henrik
authors.initials: H
authors.lastname: Flyvbjerg
authors.forename: Anders
authors.initials: A
authors.lastname: Kristensen
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000302:isolation & purification / Q000648:ultrastructure*; D004058:Diffusion; D008422:Materials Testing; D009038:Motion; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011312:Pressure
chemical_list: D004247:DNA