title: The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes.
abstract: OBJECTIVE
  The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site.
  
  
  METHODS
  In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and ophthalmological outcomes were assessed.
  
  
  RESULTS
  Islets readily engrafted on the iris and there was a decrease in exogenous insulin requirements due to insulin secretion from the intraocular grafts. No major adverse effects on eye structure and function could be observed during the transplantation period.
  
  
  CONCLUSIONS
  Our study demonstrates the long-term survival and function of allogeneic islets after transplantation into the anterior chamber of the eye. The safety and simplicity of this procedure provides support for further studies aimed at translating this technology into the clinic.
authors.affiliation: Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: V L
authors.initials: VL
authors.lastname: Perez
authors.forename: A
authors.initials: A
authors.lastname: Caicedo
authors.forename: D M
authors.initials: DM
authors.lastname: Berman
authors.forename: E
authors.initials: E
authors.lastname: Arrieta
authors.forename: M H
authors.initials: MH
authors.lastname: Abdulreda
authors.forename: R
authors.initials: R
authors.lastname: Rodriguez-Diaz
authors.forename: A
authors.initials: A
authors.lastname: Pileggi
authors.forename: E
authors.initials: E
authors.lastname: Hernandez
authors.forename: S R
authors.initials: SR
authors.lastname: Dubovy
authors.forename: J M
authors.initials: JM
authors.lastname: Parel
authors.forename: C
authors.initials: C
authors.lastname: Ricordi
authors.forename: N M
authors.initials: NM
authors.lastname: Kenyon
authors.forename: N S
authors.initials: NS
authors.lastname: Kenyon
authors.forename: P O
authors.initials: PO
authors.lastname: Berggren
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000601:surgery*; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D010215:Papio