title: Synthesis and biological activity of 2-(bis((1,3,4-oxadiazolyl/1,3,4-thiadiazolyl)methylthio)methylene)malononitriles.
abstract: The reactivity of ketene dithiolates in the presence of different equivalents of sodium ethoxide was studied. 2-(Bis((5-aryl-1,3,4-oxadiazol-2-yl)methylthio)methylene)malononitriles 5 and 2-(bis((5-aryl-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitriles 6 were prepared by the reaction of malononitrile with carbon disulfide and 5-aryl-2-(chloromethyl)-1,3,4-oxadiazoles 3/5-aryl-2-(chloromethyl)-1,3,4-thiadiazoles 4. The preliminary antimicrobial and antioxidant activities of the lead compounds were assayed.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhara Pradesh, India. vkpuram2001@yahoo.com
authors.forename: V
authors.initials: V
authors.lastname: Padmavathi
authors.forename: G
authors.initials: G
authors.lastname: Dinneswara Reddy
authors.forename: S
authors.initials: S
authors.lastname: Nagi Reddy
authors.forename: K
authors.initials: K
authors.lastname: Mahesh
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D009570:Nitriles; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; C000945:dicyanmethane