title: Kcnq1ot1: a chromatin regulatory RNA.
abstract: There is a growing interest for noncoding RNA (ncRNA)-mediated epigenetic regulation of transcription in diverse biological functions. Recent evidence suggests that a subset of long ncRNA epigenetically regulate the transcription of multiple genes in chromosomal domains via interaction with chromatin. Kcnq1ot1 is one such long chromatin-interacting ncRNA that silences multiple genes in the Kcnq1 domain by establishing a repressive higher order chromatin structure. This is done by the recruitment of chromatin and DNA-modifying proteins. This review looks at recent evidence supporting the notion that Kcnq1ot1-mediated silencing is a multilayered pathway. Comparing the mode of action of Kcnq1ot1 with other well-investigated chromatin regulatory long ncRNAs, such as Xist, HOTAIR and Airn, revealed that chromatin regulatory ncRNAs share common epigenetic pathways in the silencing of multiple genes.
authors.affiliation: Department of Immunology, Genetics and Pathology, Dag Hammarskjölds Väg 20, 75185 Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. Kanduri.Chandrasekhar@igp.uu.se
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Kanduri
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D019175:DNA Methylation; D020868:Gene Silencing; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*
chemical_list: D002843:Chromatin; D051657:KCNQ1 Potassium Channel; D022661:RNA, Untranslated