title: Nicotine treatment reduces LPS-induced sickness responses in telemetry monitoring rats.
abstract: Cholinergic anti-inflammatory pathway (CAP) inhibits unrestrained inflammatory response in a variety of experimental models. Limited research has been done yet to examine the mechanisms of activating CAP on bio-behavioral changes such as heart rate (HR), blood pressure (BP), body temperature (BT), locomotor activity (LA), and autonomic nervous activity (ANA). We observed these parameters using telemetry to clarify pathophysiological mechanisms of CAP. Nicotine significantly attenuated LPS-induced changes in HR, BP, LA, and ANA. These changes were accompanied by significant inhibition of TNF-α and IL-1β syntheses. However the LPS-induced physiological responses persisted much longer than the cytokines production. These results indicate that systemic nicotine treatment inhibits LPS-induced cytokines production and attenuates the associated physiological and behavioral sickness responses.
authors.affiliation: Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kojima
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tsubone
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kuwahara
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005786:Gene Expression Regulation / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism; D008070:Lipopolysaccharides; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D009043:Motor Activity / Q000187:drug effects; D009538:Nicotine / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013686:Telemetry; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D009538:Nicotine