title: Endolymphatic hydrops in Meniere's disease detected by MRI after intratympanic administration of gadolinium: comparison with sudden deafness.
abstract: CONCLUSIONS
  The detection rate of endolymphatic hydrops was significantly higher in patients with Meniere's disease compared with those with sudden deafness, indicating that 3 T magnetic resonance imaging (MRI) with intratympanic gadolinium injection was effective in diagnosing endolymphatic hydrops.
  
  
  OBJECTIVE
  To compare the detection rate of endolymphatic hydrops between patients with Meniere's disease and sudden deafness as controls by 3 T MRI after intratympanic gadolinium injection with conventional pulse sequence such as two-dimensional fluid-attenuated inversion recovery.
  
  
  METHODS
  Ten patients with unilateral Meniere's disease and eight with sudden deafness underwent inner ear MRI 24 h after intratympanic gadolinium injection.
  
  
  RESULTS
  The endolymphatic space was detected as a low signal intensity area, while the perilymphatic space showed high intensity by gadolinium enhancement. Due to faint enhancement, images could not be evaluated in 1 of 10 patients with Meniere's disease. However, the other nine patients together with two of the eight with sudden deafness were diagnosed as having hydrops. The difference in detection rates between the two diseases was statistically significant. Two hydrops-positive cases with sudden deafness were considered to be of the secondary type of hydrops, because images were taken after partial recovery from hearing loss several months after the onset of the disease.
authors.affiliation: Department of Otolaryngology, Suita Municipal Hospital, Osaka University Graduate School of Medicine, Japan. ahorii@ent.med.osaka-u.ac.jp
authors.forename: Arata
authors.initials: A
authors.lastname: Horii
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Osaki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kitahara
authors.forename: Takao
authors.initials: T
authors.lastname: Imai
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Uno
authors.forename: Suetaka
authors.initials: S
authors.lastname: Nishiike
authors.forename: Norihiko
authors.initials: N
authors.lastname: Fujita
authors.forename: Hidenori
authors.initials: H
authors.lastname: Inohara
mesh_terms: D000328:Adult; D000368:Aged; D001300:Audiometry, Evoked Response; D003287:Contrast Media / Q000008:administration & dosage*; D004432:Ear, Middle; D018159:Endolymphatic Hydrops / Q000175:diagnosis*; D005260:Female; D019786:Gadolinium DTPA; D003639:Hearing Loss, Sudden / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007267:Injections; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis*; D008875:Middle Aged; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA