title: [Treatment-resistant depression is treatable].
abstract: Depression is considered resistant when two treatment attempts with antidepressants from different classes fail to produce significant clinical improvement. In cases of treatment-resistant depression, it is recommended to reevaluate the diagnosis, clarify comorbidity, substance abuse and lack of compliance. Regarding treatment, evidence is sparse, but switching to a different antidepressant, and combination or augmentation with another agent, admission and treatment with ECT are the options. The choice of treatment must be based on the characteristics of the depression, the severity of treatment resistance and side effects.
authors.affiliation: Kompetencecenter for Affektive Lidelser, Psykiatrisk Center København, Hans Kirks Vej 6, 2200 København N, Denmark. maj.vinberg@rh.regionh.dk
authors.forename: Maj
authors.initials: M
authors.lastname: Vinberg
authors.forename: Mette Frandsen
authors.initials: MF
authors.lastname: Levinsen
authors.forename: Lars Vedel
authors.initials: LV
authors.lastname: Kessing
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D003937:Diagnosis, Differential; D004351:Drug Resistance; D004565:Electroconvulsive Therapy; D006801:Humans; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents