title: Detection of acyl-homoserine lactones by Escherichia and Salmonella.
abstract: Escherichia and Salmonella do not synthesize quorum-sensing signaling molecules of the N-acyl-l-homoserine lactone (AHL) type but they can detect AHLs produced by other species of bacteria. AHLs are present in the bovine rumen but not in the remainder of the gastrointestinal tract. Enterohemorrhagic E. coli (EHEC) responds to AHLs extracted from the bovine rumen. Salmonella fails to detect AHLs in the gastrointestinal tracts of pathogen-free mice or pigs, suggesting that AHLs are not present. However, Salmonella does detect the AHL production of Yersinia enterocolitica in mouse Peyer's patches. In response to AHLs, EHEC represses flagellar genes and the LEE pathogenicity island while it activates the acid fitness island, whereas Salmonella activates the rck operon and a gene, srgE, encoding a putative Type III secreted effector.
authors.affiliation: Department of Microbiology, Ohio State University, 484 West 12th Avenue, 376 Biological Sciences Building, Columbus, OH 43210, USA.
authors.forename: Jitesh A
authors.initials: JA
authors.lastname: Soares
authors.forename: Brian M M
authors.initials: BM
authors.lastname: Ahmer
mesh_terms: D054742:Acyl-Butyrolactones / Q000378:metabolism*; D000818:Animals; D054324:Enterohemorrhagic Escherichia coli / Q000254:growth & development / Q000378:metabolism*; D005407:Flagella / Q000502:physiology; D005408:Flagellin / Q000096:biosynthesis; D041981:Gastrointestinal Tract / Q000382:microbiology; D051379:Mice; D012417:Rumen / Q000382:microbiology; D012475:Salmonella / Q000378:metabolism*; D015398:Signal Transduction; D013552:Swine; D037521:Virulence Factors / Q000096:biosynthesis; D015008:Yersinia enterocolitica / Q000378:metabolism
chemical_list: D054742:Acyl-Butyrolactones; D037521:Virulence Factors; D005408:Flagellin