title: Integral dose to the carotid artery in intensity modulated radiotherapy of carcinoma nasopharynx: extended field IMRT versus split-field IMRT.
abstract: OBJECTIVE
  To evaluate the integral dose to carotid vessels in extended field intensity modulated radiotherapy (IMRT) (including the lower neck nodes in IMRT field) and split field IMRT (using separate single anterior field to treat lower neck nodes) in cancer nasopharynx.
  
  
  METHODS
  Dosimetric data from 10 patients of carcinoma nasopharynx, undergoing IMRT, were evaluated in this prospective study. The carotid vessels were contoured from sternoclavicular joints upto the base of skull. IMRT plans were generated for all patients with extended field and split field IMRT techniques using nine coplanar beams with 6 MV photons. A dose of 70 Gy to planning target volume (PTV) 70 Gy, 59.4 Gy to PTV 59.4 Gy and 54 Gy to PTV 54 Gy was delivered in 33 fractions. The dose constraints were similar for both the techniques. The integral dose to the carotid arteries was calculated as the mean dose times the volume (mean dose Χ volume) in units of liter-gray.
  
  
  RESULTS
  The mean dose to the carotid vessels in the extended field IMRT was 63.88 ± 0.97 Gy (mean dose ± SD) and it was 64.43 ± 0.73 Gy for the split field technique. The integral dose in the extended field versus split field technique was 0.29 ± 0.0207 and 0.32 ± 0.0213 liter-gray, respectively. The difference was statistically significant (P < 0.013).
  
  
  CONCLUSIONS
  Extended field IMRT delivers a slightly lower integral dose to carotid arteries in treatment of cancer nasopharynx while maintaining good dose homogeneity to the PTV 54 Gy and can be preferred over split field radiotherapy.
authors.affiliation: Department of Radiation Oncology, Delhi State Cancer Institute, New Delhi, India. dramitbahl@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Bahl
authors.forename: K S J
authors.initials: KS
authors.lastname: Basu
authors.forename: D N
authors.initials: DN
authors.lastname: Sharma
authors.forename: G K
authors.initials: GK
authors.lastname: Rath
authors.forename: P K
authors.initials: PK
authors.lastname: Julka
authors.forename: S
authors.initials: S
authors.lastname: Thulkar
mesh_terms: D000328:Adult; D002339:Carotid Arteries / Q000187:drug effects*; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage