title: Spontaneous tumor lysis syndrome with resolution of pancytopenia and disappearance of lymphadenopathy in a patient with peripheral T cell lymphoma unspecified.
abstract: Tumor lysis syndrome is a well-described, serious complication of chemotherapy administered to treat malignancies. However, a very rare event resulting in the spontaneous necrosis of a tumor prior to therapy can also occur, which is termed spontaneous tumor lysis syndrome (STLS). We present a case of a 27-year-old male who presented to the hospital with epistaxis, dyspnea, and cervical lymphadenopathy. Laboratory findings included progressive pancytopenia, hyperuricemia, and acute renal failure. Bone marrow biopsy showed a T cell lymphoid neoplasm that had entirely infiltrated the marrow stroma. The patient was diagnosed with STLS in the setting of a T cell lymphoma with bone marrow infiltration. The patient was immediately treated with a blood transfusion and hemodialysis. After this urgent treatment, the patient's pancytopenia resolved and the lymphadenopathy disappeared spontaneously. One month post-treatment, the patient's cervical lymphadenopathy recurred and peripheral T cell lymphoma, not otherwise specified, was confirmed. STLS has previously been reported, however, most known cases of STLS did not show a decreased tumor burden resulting from massive tumor cell death. We present a rare case of STLS with resolution of pancytopenia and disappearance of lymphadenopathy in a patient with peripheral T cell lymphoma not otherwise specified.
authors.affiliation: Department of Internal Medicine, Hemato-oncology, Chosun University Hospital, 588 Seoseok-dong Dong-gu, Gwangju, 501-717, Republic of Korea.
authors.forename: Sang-Gon
authors.initials: SG
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Hemato-oncology, Chosun University Hospital, 588 Seoseok-dong Dong-gu, Gwangju, 501-717, Republic of Korea.
authors.forename: Choon-Hae
authors.initials: CH
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Hemato-oncology, Chosun University Hospital, 588 Seoseok-dong Dong-gu, Gwangju, 501-717, Republic of Korea. pcy@chosun.ac.kr.
authors.forename: Chi-Young
authors.initials: CY
authors.lastname: Park
mesh_terms: D000328:Adult; D001803:Blood Transfusion; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000473:pathology* / Q000628:therapy; D008297:Male; D010198:Pancytopenia / Q000150:complications / Q000473:pathology* / Q000628:therapy; D006435:Renal Dialysis; D015275:Tumor Lysis Syndrome / Q000150:complications / Q000473:pathology* / Q000628:therapy