title: Update on microbicide research and development - seeking new HIV prevention tools for women.
abstract: Women and girls are especially vulnerable to HIV infection in sub-Saharan Africa, and in some of those countries, prevalence among young women can be up to 3 times higher than among men of the same age. Effective HIV prevention options for women are clearly needed in this setting. Several ARV-based vaginal microbicides are currently in development for prevention of HIV transmission to women and are discussed here. The concept of pre-exposure prophylaxis for the prevention of HIV transmission to women is introduced.
authors.affiliation: International Partnership for Microbicides, 8401 Colesville Road, Suite 200, Silver Spring, MD 20910, USA.
authors.forename: T
authors.initials: T
authors.lastname: Mertenskoetter
authors.forename: Paulina E
authors.initials: PE
authors.lastname: Kaptur
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000282:Administration, Intravaginal; D000328:Adult; D017954:Africa South of the Sahara / Q000453:epidemiology; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003510:Cyclohexanes / Q000008:administration & dosage; D055808:Drug Discovery / Q000639:trends; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D008297:Male; D000077592:Maraviroc; D063065:Organophosphonates / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage; D011743:Pyrimidines / Q000008:administration & dosage; D000068698:Tenofovir; D014230:Triazoles / Q000008:administration & dosage; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D003510:Cyclohexanes; C510296:MIV 150; D063065:Organophosphonates; D011725:Pyridines; D011743:Pyrimidines; D014230:Triazoles; D014508:Urea; D000068698:Tenofovir; D000225:Adenine; D000077592:Maraviroc; C481671:Dapivirine