title: Platelets, endothelium and shear join forces to mislead neutrophils in sepsis.
abstract: Neutrophils are circulating leukocytes with great cytotoxic potential, responsible for the first combat against invading pathogens. Their accumulation in tissues must be highly controlled so that the number of neutrophils delivered to the affected site is sufficient to control infection with minimum injury to the surrounding healthy tissue. In sepsis, neutrophil migration is dysregulated - resulting in insufficient delivery of neutrophils to the infectious site and massive neutrophil accumulation in uninfected organs. This dysregulation has the potential to cause inappropriate tissue injury that may explain the multiple organ dysfunction observed in severe sepsis. A better understanding of the mechanisms that contribute to this process is fundamental to design therapeutic strategies to circumvent tissue injury and organ dysfunction in sepsis.
authors.affiliation: Immunology Research Group, Department of Physiology and Pharmacology, Calvin, Phoebe & Joan Snyder Institute for Infection, Immunity & Inflammation, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1.
authors.forename: Heitor A Paula
authors.initials: HA
authors.lastname: Neto
authors.forename: Paul
authors.initials: P
authors.lastname: Kubes
mesh_terms: D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D007962:Leukocytes / Q000378:metabolism* / Q000473:pathology*; D018805:Sepsis / Q000378:metabolism*; D033081:Shear Strength / Q000502:physiology*
chemical_list: D018836:Inflammation Mediators