title: Measurement of Ca²+-ATPase activity (in PMCA and SERCA1).
abstract: Ca(2+)-ATP pumps play a vital role in intracellular calcium homeostasis and signaling. They remove excess Ca(2+) from the cytoplasm, either into the lumen of the intracellular sarcoplasmic reticulum/endoplasmic reticulum (SR/ER) network or out of the cell, and fine-tune local calcium concentrations allowing for proper functioning of a variety of Ca(2+)-dependent reactions. They are also integral components of Ca(2+)-dependent cellular events and cascades that are regulated by precisely controlled Ca(2+) concentrations.
authors.affiliation: Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Danuta
authors.initials: D
authors.lastname: Kosk-Kosicka
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology*; D004910:Erythrocyte Membrane / Q000201:enzymology*; D006706:Homeostasis; D006801:Humans; D018482:Muscle, Skeletal / Q000201:enzymology*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*
chemical_list: D000252:Calcium-Transporting ATPases; D002118:Calcium