title: Radical abdominal trachelectomy for cervical malignancies: surgical, oncological and fertility outcomes in 62 patients.
abstract: OBJECTIVE
  To report our experience of radical abdominal trachelectomy for patients with cervical malignancies.
  
  
  METHODS
  We conducted a retrospective review of a prospectively maintained database of patients undergoing fertility-sparing radical abdominal trachelectomy for cervical malignancies at our institution from 04/2004 to 09/2010.
  
  
  RESULTS
  Sixty-four patients with cervical malignancies underwent laparotomy for planned radical abdominal trachelectomy. Two patients needed immediate completion of radical hysterectomy due to unfavorable intraoperative findings. Median age was 29.5 years (range, 11-41). Histology included 8 (12.9%) with adenocarcinoma, 50 (80.65%) with squamous carcinoma, 1 (1.61%) with adenosquamous carcinoma and 3 (4.84%) with botryoid sarcoma. Median number of nodes evaluated was 25 (range, 12-53); Ten (16.13%) patients with pathologic risk factors received adjuvant therapy. Fourteen of 36 IB1 cases had tumor size >2cm. No recurrences were observed at a median follow-up of 22.8 months. Five (8.06%) patients developed postoperative cervical stenosis--all occurred before we started to routinely install T-IUDs during the procedure. Thirty-eight patients completed the survey which aimed to understand what factors influenced these patients' reproductive outcomes. For various reasons, only 10 patients attempted to conceive and 2 of them succeeded. One of them delivered by cesarean section after 39 weeks and the other is currently pregnant.
  
  
  CONCLUSIONS
  Radical abdominal trachelectomy seems to be a reasonable option for selected patients whose tumors are no larger than 4cm when conducted by experienced gynecologic oncologists. The main perioperative complication is postoperative cervical stenosis, which could be effectively prevented by installation of a tailed T-IUD during the surgery. Social, familial and physical factors can largely influence the patients' reproductive outcomes. The issues of reproductive concerns and quality of life require further investigation.
authors.affiliation: Department of Gynecologic Oncology, Cancer Hospital of Fudan University, 399 Ling-Ling Road, Shanghai, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Ziting
authors.initials: Z
authors.lastname: Li
authors.forename: Huaying
authors.initials: H
authors.lastname: Wang
authors.forename: Rongyu
authors.initials: R
authors.lastname: Zang
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xingzhu
authors.initials: X
authors.lastname: Ju
authors.forename: Guihao
authors.initials: G
authors.lastname: Ke
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005298:Fertility; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D007813:Laparotomy / Q000379:methods; D008197:Lymph Node Excision; D011247:Pregnancy; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D055815:Young Adult