title: Association of a CYP17 gene polymorphism with development of breast cancer in India.
abstract: The human CYP17 gene, located on chromosome 10q24.3, plays a key role in sex steroid synthesis, mainly related to estrogen. A 5' UTR polymorphism involving a single base pair change in the promoter region results in increased transcriptional activity. In the present study of 250 breast cancer cases and 250 ma tched controls, the A1 genotype frequency was elevated in the disease group, while the A2 genotype frequency demonstrated no association. When data were stratified by risk conferring group, however, the A2 genotype frequency was increased in postmenopausal breast cancer cases (4.2%), patients positive for a family history of breast cancer (5.5%), high BMI, estrogen receptor (6.2%) and progesterone receptor negative (5.0%) status, HER2/neu positive (7.7%) status, positive node status (5.0%) as well as advanced stage of the disease. The A1A1 genotype linked with increased production of androgens might impact on onset of breast cancer while the A2 allele showed associations with respect to important risk conferring parameters.
authors.affiliation: Department of Genetics, Osmania University, India.
authors.forename: D
authors.initials: D
authors.lastname: Surekha
authors.forename: K
authors.initials: K
authors.lastname: Sailaja
authors.forename: D Nageswara
authors.initials: DN
authors.lastname: Rao
authors.forename: T
authors.initials: T
authors.lastname: Padma
authors.forename: D
authors.initials: D
authors.lastname: Raghunadharao
authors.forename: S
authors.initials: S
authors.lastname: Vishnupriya
mesh_terms: D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007194:India; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D012307:Risk Factors; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*
chemical_list: D013254:Steroid 17-alpha-Hydroxylase