title: Visualization of 3D volumetric lung dynamics for real-time external beam lung radiotherapy.
abstract: This paper reports on the usage of physics-based 3D volumetric lung dynamic models for visualizing and monitoring the radiation dose deposited on the lung of a human subject during lung radiotherapy. The dynamic model of each subject is computed from a 4D Computed Tomography (4DCT) imaging acquired before the treatment. The 3D lung deformation and the radiation dose deposited are computed using Graphics Processing Units (GPU). Additionally, using the dynamic lung model, the airflow inside the lungs during the treatment is also investigated. Results show the radiation dose deposited on the lung tumor as well as the surrounding tissues, the combination of which is patient-specific and varies from one treatment fraction to another.
authors.affiliation: Department of Radiation Oncology, University of California, Los Angeles, 200 UCLA Medical Plaza, Suite B265 Los Angeles, CA 90095, USA.
authors.forename: Anand P
authors.initials: AP
authors.lastname: Santhanam
authors.forename: Harini
authors.initials: H
authors.lastname: Neelakkantan
authors.forename: Yugang
authors.initials: Y
authors.lastname: Min
authors.forename: Nicolene
authors.initials: N
authors.lastname: Papp
authors.forename: Akash
authors.initials: A
authors.lastname: Bhargava
authors.forename: Kevin
authors.initials: K
authors.lastname: Erhart
authors.forename: Xiang
authors.initials: X
authors.lastname: Long
authors.forename: Rebecca
authors.initials: R
authors.lastname: Mitchell
authors.forename: Eduardo
authors.initials: E
authors.lastname: Divo
authors.forename: Alain
authors.initials: A
authors.lastname: Kassab
authors.forename: Olusegun
authors.initials: O
authors.lastname: Ilegbusi
authors.forename: Bari H
authors.initials: BH
authors.lastname: Ruddy
authors.forename: Jannick P
authors.initials: JP
authors.lastname: Rolland
authors.forename: Sanford L
authors.initials: SL
authors.lastname: Meeks
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Kupelian
mesh_terms: D003199:Computer Systems; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D009929:Organ Size; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods; D055425:Respiratory-Gated Imaging Techniques / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014584:User-Computer Interface