title: [Antiviral activities of cycloheximide and its derivatives].
abstract: Cycloheximide (CHX) inhibits protein synthesis in most eukaryotic cells and it is a well-known tool commonly used in biochemical research. In this paper, the antiviral spectrum of CHX against several DNA and RNA viruses have been evaluated. CHX showed strong inhibitory activities against several RNA viruses such as HIV-1, influenza viruses, coxsackie B virus, enterovirus (EV71) and several DNA viruses such as HSV and HCMV. Especially the strong inhibitory activities of CHX against coxsackie B virus and enterovirus caught our attention, since effective drugs available in clinic are limited. The SAR of CHX derivatives also has been discussed in the paper. The hydroxyl group at C-2' and carbonyl group at C-2" of CHX are essential for its antiviral activity. And modification to these groups results its derivatives' antiviral activities reduced or lost.
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Hui-fang
authors.initials: HF
authors.lastname: Guo
authors.forename: Yu-huan
authors.initials: YH
authors.lastname: Li
authors.forename: Pei-zhen
authors.initials: PZ
authors.lastname: Tao
authors.forename: Hong
authors.initials: H
authors.lastname: Yi
authors.forename: Shu-qin
authors.initials: SQ
authors.lastname: Wang
authors.forename: Wei-ying
authors.initials: WY
authors.lastname: He
authors.forename: Jian-dong
authors.initials: JD
authors.lastname: Jiang
authors.forename: Zhuo-rong
authors.initials: ZR
authors.lastname: Li
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D003513:Cycloheximide / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004267:DNA Viruses / Q000187:drug effects*; D004770:Enterovirus / Q000187:drug effects; D029822:Enterovirus B, Human / Q000187:drug effects; D006801:Humans; D012328:RNA Viruses / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D003513:Cycloheximide