title: [About a case of multiple endocrine neoplasia type 1. Review of some clinical manifestations and treatment controversies].
abstract: The rare hereditary syndrome, multiple endocrine neoplasia type1 (MEN-1), is known to predispose affected individuals to endocrine neoplasms in a variety of tissues such as the parathyroid glands, the pituitary gland and the gastrointestinal tract. We describe the case of a man with traditionally-described manifestations (hyperparathyroidism and gastrinoma) and with other tumoral lesions arising from endocrine cells (insulinoma, gastric carcinoid, adrenal adenoma and pancreatic non-functioning neuroendocrine tumors) and non-endocrine cells (lipoma and collagenoma). Frequent recurrences in susceptible tissues that are not totally removed (as occurs in hyperparathyroidism and duodenal gastrinoma) and their unknown clinical significance have aroused current controversies in the therapeutic management of these entities, which is briefly reviewed.
authors.affiliation: Servicio de Endocrinología, Hospital de Móstoles, Móstoles, Madrid, España. crisfami@terra.es
authors.forename: Cristina
authors.initials: C
authors.lastname: Familiar
authors.forename: Teresa
authors.initials: T
authors.lastname: Antón
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Moraga
authors.forename: Araceli
authors.initials: A
authors.lastname: Ramos
authors.forename: Angel
authors.initials: A
authors.lastname: Marco
mesh_terms: D000236:Adenoma / Q000235:genetics; D000310:Adrenal Gland Neoplasms / Q000235:genetics; D000328:Adult; D002276:Carcinoid Tumor / Q000235:genetics; D003131:Combined Modality Therapy; D004379:Duodenal Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D005350:Fibroma / Q000235:genetics; D015408:Gastrinoma / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D006801:Humans; D006961:Hyperparathyroidism / Q000188:drug therapy / Q000235:genetics; D007340:Insulinoma / Q000235:genetics; D008067:Lipoma / Q000235:genetics; D008207:Lymphatic Metastasis; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1 / Q000188:drug therapy / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000188:drug therapy / Q000235:genetics; D015282:Octreotide / Q000627:therapeutic use; D009853:Omeprazole / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000601:surgery; D012878:Skin Neoplasms / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics
chemical_list: D009853:Omeprazole; D015282:Octreotide