title: Membrane invasion culture system.
abstract: Metastasis is the major cause of morbidity and death for cancer patients. A critical challenge to clinical and basic scientists is the development of improved prognostic methods to predict the metastatic aggressiveness of a patient's individual tumor and especially to control local invasion-a key step in the metastatic cascade. Before effective therapeutic regimens can be planned, we must invest more effort in understanding the pathogenesis of tumor cell dissemination in order to identify better targets for clinical intervention.
authors.affiliation: Department of Anatomy and Cell Biology and The Holden Comprehensive Cancer Center, College of Medicine, University of Iowa, Iowa City, IA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Hendrix
authors.forename: E A
authors.initials: EA
authors.lastname: Seftor
authors.forename: R E
authors.initials: RE
authors.lastname: Seftor