title: New solid mucoadhesive systems for benzydamine vaginal administration.
abstract: The aim of this work was the realization of new formulations for vaginal application to improve the pharmacological effect of benzydamine, displaying both anti-inflammatory and antiseptic activities. For this reasons, this drug was formulated in solid dispersions, by using the mucoadhesive polymers HPMC and/or Carbopol(®), then compressed. Tablets were characterized by studies of friability, hardness, hydration, DSC, mucoadhesion and in vitro release. Kinetics, responsible for drug delivery, was investigated as well. Tablets prepared by using only HPMC showed the best results in terms of swelling and mucoadhesion (time and force) together with prolonged and complete drug release, by diffusive mechanism, through gelled layer. Despite the good mucoadhesive properties, Carbopol(®) does not represent a good excipient because, after the contact with water, it generates a spongy gel layer, not homogeneous, stiff, brittle and with breaking tendency when highly swelled. This kind of gel does not guarantee a linear drug release and could provoke discomfort because of fragment release. HPMC mucoadhesive tablets could be a proper delivery system for benzydamine administration representing a good alternative to traditional dosage forms for vaginal topical therapy.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Via del Liceo 1, Perugia 06123, Italy. luanaper@unipg.it
authors.forename: Luana
authors.initials: L
authors.lastname: Perioli
authors.forename: Valeria
authors.initials: V
authors.lastname: Ambrogi
authors.forename: Cinzia
authors.initials: C
authors.lastname: Pagano
authors.forename: Elena
authors.initials: E
authors.lastname: Massetti
authors.forename: Carlo
authors.initials: C
authors.lastname: Rossi
mesh_terms: D000268:Adhesiveness; D000282:Administration, Intravaginal; D000818:Animals; D001591:Benzydamine / Q000737:chemistry* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008747:Methylcellulose / Q000737:chemistry* / Q000494:pharmacology; D004364:Pharmaceutical Preparations; D013552:Swine; D013607:Tablets; D014621:Vagina / Q000187:drug effects*
chemical_list: D004364:Pharmaceutical Preparations; D013607:Tablets; D001591:Benzydamine; D008747:Methylcellulose