title: Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus.
abstract: The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved in cholesterol biosynthesis, and microRNA-33a, which has recently been shown to reduce expression of proteins involved in export of cholesterol and β-oxidation of fatty acids, thus adding an unexpected layer of complexity and fine-tuning to regulation of lipid homeostasis.
authors.affiliation: Laboratory of Physiological Chemistry, de Duve Institute, Université Catholique de Louvain, Avenue Hippocrate 75.39, 1200 Bruxelles, Belgium. guido.bommer@uclouvain.be
authors.forename: Guido T
authors.initials: GT
authors.lastname: Bommer
authors.forename: Ormond A
authors.initials: OA
authors.lastname: MacDougald
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D051782:Sterol Regulatory Element Binding Protein 2 / Q000235:genetics / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D035683:MicroRNAs; D051782:Sterol Regulatory Element Binding Protein 2; D002784:Cholesterol