title: Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies.
abstract: Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies.
authors.affiliation: Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi, Japan. fujitaku@hp.pref.hyogo.jp
authors.forename: T
authors.initials: T
authors.lastname: Fujimoto
authors.forename: T
authors.initials: T
authors.lastname: Andoh
authors.forename: T
authors.initials: T
authors.lastname: Sudo
authors.forename: I
authors.initials: I
authors.lastname: Fujita
authors.forename: M
authors.initials: M
authors.lastname: Imabori
authors.forename: H
authors.initials: H
authors.lastname: Moritake
authors.forename: T
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Sakuma
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: H
authors.initials: H
authors.lastname: Sonobe
authors.forename: Alan L
authors.initials: AL
authors.lastname: Epstein
authors.forename: T
authors.initials: T
authors.lastname: Akisue
authors.forename: M
authors.initials: M
authors.lastname: Kirihata
authors.forename: M
authors.initials: M
authors.lastname: Kurosaka
authors.forename: Y
authors.initials: Y
authors.lastname: Fukumori
authors.forename: H
authors.initials: H
authors.lastname: Ichikawa
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy; D045744:Cell Line, Tumor; D006801:Humans; D066298:In Vitro Techniques; D008546:Melanoma, Experimental / Q000378:metabolism; D008854:Microscopy, Electron; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D018227:Sarcoma, Clear Cell / Q000378:metabolism*
chemical_list: D001896:Boron Compounds; D010649:Phenylalanine; C033685:4-boronophenylalanine