title: Glucocorticoids in pregnancy.
abstract: The fetus may be exposed to increased endogenous or synthetic glucocorticoid (GS) exposure in late gestation. Approximately 7% of pregnant women in Europe and North America are treated with synthetic GSs to promote lung maturation in fetuses at risk of preterm delivery. Maternal steroid treatment before preterm delivery is one of the best documented and most cost effective life saving treatments in prenatal medicine but, in certain circumstances, the price of accelerated lung maturity may be loss of brain cells, increased neurodevelopmental disability, intra-uterine growth restriction (IUGR), and an increased risk of preterm delivery, of programming of post-natal hypertension, and of increased post-natal activity in the hypothalamo-pituitary-adrenal (HPA) axis. Placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) is the key enzyme which protects the fetus from overexposure to GSs by their oxidation into inactive derivates. We review the evidence for the metabolism of GSs during pregnancy and how endogenous and synthetic GSs cause other changes in the placenta which affect fetal development.
authors.affiliation: Department of Obstetrics and Perinatology, Medical University of Lublin, Jaczewskiego 8, PL, 20-954 Lublin, Poland. marciniak.alex@gmail.com
authors.forename: Beata
authors.initials: B
authors.lastname: Marciniak
authors.forename: Jolanta
authors.initials: J
authors.lastname: Patro-Małysza
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Poniedziałek-Czajkowska
authors.forename: Zaneta
authors.initials: Z
authors.lastname: Kimber-Trojnar
authors.forename: Bożena
authors.initials: B
authors.lastname: Leszczyńska-Gorzelak
authors.forename: Jan
authors.initials: J
authors.lastname: Oleszczuk
mesh_terms: D000818:Animals; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects / Q000378:metabolism*; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids