title: Yersinia pseudotuberculosis is resistant to killing by human neutrophils.
abstract: The interaction between human neutrophils and the Gram negative gastrointestinal pathogen Yersinia pseudotuberculosis was investigated in vitro. Despite the wealth of data describing how Yersinia can affect the function of neutrophils, there are no published studies describing if neutrophil cells can affect the viability of Y. pseudotuberculosis. The wild-type IP32953 strain of Y. pseudotuberculosis was found to be resistant to killing by human neutrophils. Confocal examination and flow-cytometric analysis of this interaction revealed that bacteria were taken up.
authors.affiliation: Defence Science and Technology Laboratory, Salisbury, Wiltshire SP4 OJQ, UK. trlaws@dstl.gov.uk
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Laws
authors.forename: Martin S
authors.initials: MS
authors.lastname: Davey
authors.forename: Christopher
authors.initials: C
authors.lastname: Green
authors.forename: Ian A M
authors.initials: IA
authors.lastname: Cooper
authors.forename: Richard W
authors.initials: RW
authors.lastname: Titball
authors.forename: Roman A
authors.initials: RA
authors.lastname: Lukaszewski
mesh_terms: D004705:Endocytosis; D005434:Flow Cytometry; D006801:Humans; D050296:Microbial Viability; D018613:Microscopy, Confocal; D009504:Neutrophils / Q000276:immunology*; D015011:Yersinia pseudotuberculosis / Q000276:immunology*