title: Acute isolated ophthalmoplegia with anti-GQ1b antibodies.
abstract: Ophthalmoplegia without ataxia, areflexia or both has been designated as atypical Miller Fisher syndrome (MFS) or acute ophthalmoplegia (AO). This entity, first reported by Chiba et al. is associated with anti-GQ1b IgG antibodies.We report a patient with isolated acute ophthalmoplegia with high titer of anti-GQ1b IgG antibody activity in the acute phase in whom treatment with intravenous immunoglobulin (IVIg) led to the clinical recovery and the decrease in antibody titer.
authors.affiliation: Department of Neurology, Alessandro Manzoni General Hospital, Lecco, Italy. rig74@libero.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Rigamonti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lauria
authors.forename: Marco
authors.initials: M
authors.lastname: Longoni
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Stanzani
authors.forename: Elio
authors.initials: E
authors.lastname: Agostoni
mesh_terms: D000208:Acute Disease; D000328:Adult; D001763:Blepharoptosis / Q000209:etiology; D004172:Diplopia / Q000209:etiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D019846:Miller Fisher Syndrome / Q000276:immunology* / Q000628:therapy*; D009431:Neural Conduction / Q000502:physiology; D009460:Neurologic Examination
chemical_list: D005732:Gangliosides; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; C039129:GQ1b ganglioside