title: Urinary pharmacokinetics and bactericidal activity of finafloxacin (200 and 800 mg) in healthy volunteers receiving a single oral dose.
abstract: BACKGROUND
  Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection.
  
  
  METHODS
  Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a reference strain and 9 selected clinical uropathogens at the pH of native, acidified (pH 5.5) and alkalinized (pH 8.0) urine.
  
  
  RESULTS
  The mean maximum urine concentrations for 200 and 800 mg finafloxacin were 69.3 mg/l (0-2 h) and 150 mg/l (4-8 h). Median UBT were between 0 and 1:>2,048 and were in general agreement with minimal inhibitory concentrations of strains and urinary pH values. UBT in alkaline urine were significantly lower than those in native or acidic urine, except for Enterococcus faecalis.
  
  
  CONCLUSIONS
  Finafloxacin exhibited significant bactericidal activity against susceptible uropathogens. The urinary bactericidal activity of finafloxacin was enhanced in acidic urine and significantly lower in alkaline urine.
authors.affiliation: Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Giessen, Germany. Wagenlehner@aol.com
authors.forename: Florian M E
authors.initials: FM
authors.lastname: Wagenlehner
authors.forename: Christine M
authors.initials: CM
authors.lastname: Wagenlehner
authors.forename: Birgit
authors.initials: B
authors.lastname: Blenk
authors.forename: Holger
authors.initials: H
authors.lastname: Blenk
authors.forename: Sabine
authors.initials: S
authors.lastname: Schubert
authors.forename: Axel
authors.initials: A
authors.lastname: Dalhoff
authors.forename: Kurt G
authors.initials: KG
authors.lastname: Naber
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000652:urine*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000652:urine*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008826:Microbial Sensitivity Tests; D010919:Placebos; D014556:Urine / Q000382:microbiology
chemical_list: D000892:Anti-Infective Agents, Urinary; D024841:Fluoroquinolones; D010919:Placebos; C560572:finafloxacin