title: Comosusols A-D and comosone A: cytotoxic compounds from the brown alga Sporochnus comosus.
abstract: Bioassay-guided fractionation of extracts of the brown alga Sporochnus comosus led to the isolation of five new compounds, comosusols A-D (3-6) and comosone A (7). The structures of all isolated compounds were elucidated using standard one- and two-dimensional NMR techniques, as well as comparison with literature values. The cytotoxic activity of all compounds was investigated against a panel of human tumor and mammalian cell lines. These assays found eight of the nine compounds had GI(50) values in the 8-63 μM range.
authors.affiliation: Australian Institute of Marine Science, PMB No. 3, Townsville MC, Townsville, 4810, Australia.
authors.forename: Simon P B
authors.initials: SP
authors.lastname: Ovenden
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Nielson
authors.forename: Catherine H
authors.initials: CH
authors.lastname: Liptrot
authors.forename: Richard H
authors.initials: RH
authors.lastname: Willis
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wright
authors.forename: Cherie A
authors.initials: CA
authors.lastname: Motti
authors.forename: Dianne M
authors.initials: DM
authors.lastname: Tapiolas
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001315:Australia; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000459:Phaeophyceae / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D003512:Cyclohexanones; D010636:Phenols; D011809:Quinones; C559167:comosone A