title: Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.
authors.affiliation: Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com
authors.forename: Muthiah
authors.initials: M
authors.lastname: Manoharan
authors.forename: Akin
authors.initials: A
authors.lastname: Akinc
authors.forename: Rajendra K
authors.initials: RK
authors.lastname: Pandey
authors.forename: June
authors.initials: J
authors.lastname: Qin
authors.forename: Philipp
authors.initials: P
authors.lastname: Hadwiger
authors.forename: Matthias
authors.initials: M
authors.lastname: John
authors.forename: Kathy
authors.initials: K
authors.lastname: Mills
authors.forename: Klaus
authors.initials: K
authors.lastname: Charisse
authors.forename: Martin A
authors.initials: MA
authors.lastname: Maier
authors.forename: Lubomir
authors.initials: L
authors.lastname: Nechev
authors.forename: Emily M
authors.initials: EM
authors.lastname: Greene
authors.forename: Pradeep S
authors.initials: PS
authors.lastname: Pallan
authors.forename: Eriks
authors.initials: E
authors.lastname: Rozners
authors.forename: Kallanthottathil G
authors.initials: KG
authors.lastname: Rajeev
authors.forename: Martin
authors.initials: M
authors.lastname: Egli
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D005461:Fluorine / Q000737:chemistry*; D020868:Gene Silencing; D009690:Nucleic Acid Conformation; D017434:Protein Structure, Tertiary; D034741:RNA, Small Interfering / Q000737:chemistry*; D034743:RNA-Induced Silencing Complex / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D034741:RNA, Small Interfering; D034743:RNA-Induced Silencing Complex; D005461:Fluorine