title: A damage limitation exercise.
abstract: Cellular senescence is a potent tumour suppressor mechanism that is often accompanied by activation of dna damage response (DDR) signalling and marked heterochromatinization. Senescence-associated heterochromatin is now shown to limit DDR, thus reducing apoptosis and promoting survival of senescent cells.
authors.forename: Andrejs
authors.initials: A
authors.lastname: Ivanov
authors.forename: Peter D
authors.initials: PD
authors.lastname: Adams
mesh_terms: D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D016922:Cellular Senescence; D016207:Cytokines / Q000378:metabolism; D004249:DNA Damage; D006570:Heterochromatin / Q000737:chemistry* / Q000378:metabolism; D006657:Histones / Q000737:chemistry; D006801:Humans; D007249:Inflammation; D009369:Neoplasms / Q000628:therapy; D016160:Retinoblastoma Protein / Q000378:metabolism; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016207:Cytokines; D006570:Heterochromatin; D006657:Histones; D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53