title: Benefits of home-based endurance training in lung transplant recipients.
abstract: BACKGROUND
  To investigate the effect of home-based exercise training on exercise tolerance, muscle function and quality of life in lung transplant recipients (LTR).
  
  
  METHODS
  Twelve LTR and 7 age-matched healthy subjects underwent exercise training (ET, 12-wk, 3×/wk, 40 min). Peak aerobic capacity VO2peak, endurance time (T(end)), minute ventilation (VE) quadriceps strength, percentage of type I fiber (%Ifb), fiber diameters and chronic respiratory questionnaire were assessed before and after ET. A positive response to ET was defined as an improvement in T(end) at least comparable to the mean change observed in healthy subjects.
  
  
  RESULTS
  Training significantly improved T(end) (+12 ± 11 min), isowatt during exercise (-5.5 ± 2.6L/min), muscle strength (+4.6 ± 2.6 kg) and dyspnea score (+0.6 ± 0.9) in LTR (p < 0.05), leading to recovery of T(end) and muscle strength up to healthy subjects' values. In responders (n = 6), VO2peak, %Ifb and fatigue score were improved after training (p < 0.05). Non-responders had lower %Ifb and greater delay between surgery and the beginning of the study than responders (56 [21-106] vs. 8 [2-59] months respectively, p = 0.03).
  
  
  CONCLUSIONS
  Home-based ET was effective to improve exercise tolerance, muscle strength and quality of life in LTR but more successful in patients with moderate muscle dysfunction and in the first years after transplantation. Multicenter and controlled-studies are needed to confirm the benefits and optimal modalities of home training in LTR.
authors.affiliation: Inserm U1042, HP2 Laboratory, Joseph Fourier University, 38043 Grenoble, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Vivodtzev
authors.forename: Christophe
authors.initials: C
authors.lastname: Pison
authors.forename: Karen
authors.initials: K
authors.lastname: Guerrero
authors.forename: Paulette
authors.initials: P
authors.lastname: Mezin
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Maclet
authors.forename: Jean-Christian
authors.initials: JC
authors.lastname: Borel
authors.forename: Phillipe
authors.initials: P
authors.lastname: Chaffanjon
authors.forename: Rachid
authors.initials: R
authors.lastname: Hacini
authors.forename: Olivier
authors.initials: O
authors.lastname: Chavanon
authors.forename: Dominique
authors.initials: D
authors.lastname: Blin
authors.forename: Bernard
authors.initials: B
authors.lastname: Wuyam
mesh_terms: D000328:Adult; D000368:Aged; D015444:Exercise / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology*; D012123:Pulmonary Ventilation / Q000502:physiology; D011788:Quality of Life; D012129:Respiratory Function Tests; D014180:Transplantation / Q000502:physiology / Q000534:rehabilitation*; D055815:Young Adult