title: [Role of obesity in the development of osteoarthrosis and concomitant diseases].
abstract: OBJECTIVE
  To specify the association between obesity and the frequency of concomitant states, fat metabolic disturbances, and progressive osteoarthrosis (OA) at various sites.
  
  
  METHODS
  The study included 298 patients with manifest knee and hip osteoarthrosis in whom the body mass index (BMI) and waist and hip circumferences were measured calculating the waist-hip index. The association of these indices with the severity of OA and the development of concomitant states was analyzed.
  
  
  RESULTS
  Both women and men were found to have overweight and first-second-degree obesity at equal ratios - 61.6 and 59%, respectively. There was an evident rise in the prevalence of cardiovascular diseases (arterial hypertension, coronary heart disease) and diabetes mellitus with a higher BMI. Stages II-III gonarthrosis was predominant (97.1%) in the obesity group (BMI 30.0-35.0 or greater). With a BMI of > 40, X-ray stages III-IV OA were revealed in 83.3% of the patients.
  
  
  CONCLUSIONS
  Our findings support the important role of obesity as a risk factor in the development of OA. Fat metabolic disturbances also make a considerable contribution in the development of concomitant states and in the progression of OA of both knee and hand joints.
authors.forename: L N
authors.initials: LN
authors.lastname: Denisov
authors.forename: V A
authors.initials: VA
authors.lastname: Nasonova
authors.forename: G G
authors.initials: GG
authors.lastname: Koreshkov
authors.forename: N G
authors.initials: NG
authors.lastname: Kashevarova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism; D015207:Osteoarthritis, Hip / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D020370:Osteoarthritis, Knee / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D012720:Severity of Illness Index