title: Exploring therapeutic decisions in elderly patients with non-small cell lung cancer: results and conclusions from North Central Cancer Treatment Group Study N0222.
abstract: How do oncologists choose therapy for the elderly? Oncologists assigned patients aged 65 years or older with incurable non-small cell lung cancer to: (a) carboplatin (AUC = 2) + paclitaxel 50 mg/m(2) days 1, 8, 15 (28-day cycle × 4) followed by gefitinib; or (b) gefitinib 250 mg/day. With (a), 12 of 34 were progression-free at 6 months; median time to cancer progression was 3.9 months. With (b), the same occurred in 11 of 28 patients with the latter being 4.9 months. The most common reason for conventional chemotherapy was oncologists' opinion that the cancer was aggressive, and for gefitinib alone, patients' reluctance to receive chemotherapy. Interestingly, age had no influence.
authors.affiliation: Mayo Clinic Rochester, Rochester, Minnesota 55905, USA.
authors.forename: Heidi
authors.initials: H
authors.lastname: Mc Kean
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Stella
authors.forename: Shauna L
authors.initials: SL
authors.lastname: Hillman
authors.forename: Kendrith M
authors.initials: KM
authors.lastname: Rowland
authors.forename: Michael W
authors.initials: MW
authors.lastname: Cannon
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Behrens
authors.forename: Gerald G
authors.initials: GG
authors.lastname: Gross
authors.forename: Mark D
authors.initials: MD
authors.lastname: Sborov
authors.forename: Eliot L
authors.initials: EL
authors.lastname: Friedman
authors.forename: Aminah
authors.initials: A
authors.lastname: Jatoi
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D018579:Patient Selection; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data; D011799:Quinazolines / Q000008:administration & dosage; D011795:Surveys and Questionnaires; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
chemical_list: D011799:Quinazolines; D016190:Carboplatin; D017239:Paclitaxel; D000077156:Gefitinib