title: Olopatadine hydrochloride inhibits capsaicin-induced flare response in humans.
abstract: Capsaicin, a vanilloid, has the potential for releasing substance P (SP) from sensory nerves. Topical application of capsaicin induces a flare response in the skin. However, it has not been clarified whether the release of SP is involved in the process of flare response or not. A potent antihistamine drug, olopatadine hydrochloride, is known to have inhibitory action against the release of SP. We examined the effects of olopatadine (at a dose of 5 mg) on skin reaction induced by topical application of capsaicin in 10 healthy subjects. The scores of capsaicin-induced flare responses after olopatadine administration were significantly lower at 30 min than at baseline. Our findings suggest that olopatadine hydrochloride could inhibit capsaicin-induced flare responses.
authors.affiliation: Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan. shindo@grape.med.tottori-u.ac.jp
authors.forename: Masahisa
authors.initials: M
authors.lastname: Shindo
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamamoto
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002211:Capsaicin / Q000008:administration & dosage / Q000009:adverse effects*; D003990:Dibenzoxepins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004890:Erythema / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D039563:Histamine H1 Antagonists, Non-Sedating / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D000069605:Olopatadine Hydrochloride; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D013373:Substance P / Q000037:antagonists & inhibitors / Q000378:metabolism; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003990:Dibenzoxepins; D039563:Histamine H1 Antagonists, Non-Sedating; D000069605:Olopatadine Hydrochloride; D013373:Substance P; D002211:Capsaicin