title: Prevalence of abnormal glycometabolism in patients with chronic hepatitis C and related risk factors in China.
abstract: BACKGROUND
  An epidemiologic link between hepatitis C virus (HCV) and abnormal glycometabolism had been established. This study was designed to investigate the prevalence of type 2 diabetes mellitus and insulin resistance, and to explore the relation between insulin resistance and hepatitis C virus genotype, serum hepatitis C virus-RNA level in chronic hepatitis C (CHC) patients.
  
  
  METHODS
  Three hundred and fifty-nine consecutive patients (CHC, n = 296; chronic hepatitis B (CHB), n = 63) were evaluated. HCV genotyping was performed by restriction fragment method and serum hepatitis C virus-RNA quantified PCR for all CHC patients in the baseline serum. Fasting levels of insulin and glucose were measured in all patients and the homeostatic assessment of insulin resistance was calculated in the baseline serum.
  
  
  RESULTS
  Type 2 diabetes mellitus was diagnosed in 15.5% of 296 CHC patients. Insulin resistance was present in 23.8% of the 235 nondiabetic CHC patients, in 23.1% of the 182 nondiabetic and noncirrhotic CHC patients, and associated with high serum HCV RNA level (OR: 1.754; 95%CI: 1.207 - 2.548, P = 0.003) and age > 40 years (OR: 3.542; 95%CI: 1.257 - 9.978, P = 0.017). Insulin resistance was less frequent in CHB than in matched CHC (7.9% vs. 21.4% respectively, P < 0.0001).
  
  
  CONCLUSIONS
  The incidence of insulin resistance in CHC was significantly higher than that in CHB patients, associated with high serum HCV RNA level and age > 40 years.
authors.affiliation: Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China.
authors.forename: Li-Fen
authors.initials: LF
authors.lastname: Wang
authors.forename: Chi-Hong
authors.initials: CH
authors.lastname: Wu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shan
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Fan
authors.forename: Na
authors.initials: N
authors.lastname: Huo
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Lu
authors.forename: Xiao-Yuan
authors.initials: XY
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism / Q000821:virology; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D019698:Hepatitis C, Chronic / Q000097:blood / Q000378:metabolism* / Q000821:virology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000235:genetics; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D012367:RNA, Viral