title: Dissecting the human immunologic memory for pathogens.
abstract: Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection necessary for vaccine development. In this article, we provide an overview of the cellular basis of immunologic memory. We also describe experimental approaches based on high throughput cell cultures, which we have developed to interrogate human memory T cells, B cells, and plasma cells. We discuss how these approaches can provide new tools and information for vaccine design, in a process that we define as 'analytic vaccinology'.
authors.affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland.
authors.forename: Christina E
authors.initials: CE
authors.lastname: Zielinski
authors.forename: Davide
authors.initials: D
authors.lastname: Corti
authors.forename: Federico
authors.initials: F
authors.lastname: Mele
authors.forename: Dora
authors.initials: D
authors.lastname: Pinto
authors.forename: Antonio
authors.initials: A
authors.lastname: Lanzavecchia
authors.forename: Federica
authors.initials: F
authors.lastname: Sallusto
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D015195:Drug Design; D054884:Host-Pathogen Interactions; D006801:Humans; D007156:Immunologic Memory; D013601:T-Lymphocytes / Q000276:immunology*; D014612:Vaccines / Q000276:immunology
chemical_list: D014612:Vaccines