title: Metformin-induced lactic acidosis: no one left behind.
abstract: Metformin is a safe drug when correctly used in properly selected patients. In real life, however, associated lactic acidosis has been repeatedly, although rarely, reported. The term metformin-induced lactic acidosis refers to cases that cannot be explained by any major risk factor other than drug accumulation, usually due to renal failure. Treatment consists of vital function support and drug removal, mainly achieved by renal replacement therapy. Despite dramatic clinical presentation, the prognosis of metformin-induced lactic acidosis is usually surprisingly good.
authors.affiliation: Centro Nazionale di Informazione Tossicologica-Centro Antiveleni, IRCCS Fondazione Salvatore Maugeri, Via S. Maugeri 10, 27100 Pavia, Italy.
authors.forename: Sarah
authors.initials: S
authors.lastname: Vecchio
authors.forename: Alessandro
authors.initials: A
authors.lastname: Protti
mesh_terms: D000140:Acidosis, Lactic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008687:Metformin / Q000009:adverse effects*; D012720:Severity of Illness Index
chemical_list: D008687:Metformin