title: [Expression of RUNX3 protein in hepatic cell carcinoma and its clinicopathological implications].
abstract: OBJECTIVE
  To investigate the expression of RUNX3 protein in hepatic cell carcinoma (HCC) and its relationship with the clinicopathological factors of HCC.
  
  
  METHODS
  Immunohistochemistry was performed to detect the expression of RUNX3 protein in HCC and the surrounding normal tissues, and the relation of RUNX3 with the clinicopathological factors of HCC was analyzed.
  
  
  RESULTS
  The positivity rate of RUNX3 protein expression was 49.02% (25/51) in HCC tissues, significantly lower than that in the surrounding normal tissues [82.35% (42/51), Χ(2)=12.5706, P<0.01). RUNX3 protein expression varied significantly with such pathological factors as the differentiation degree, cancer-associated thrombosis in the portal vein and intrahepatic metastasis (P<0.05), but not with tumor diameter, location, tumoral hemorrhage, necrosis or histotypes of the tumor (P>0.05).
  
  
  CONCLUSIONS
  RUNX3 protein expression is lowered in HCC as compared with that in the surrounding normal tissue, suggesting an important role of RUNX3 in the tumorigenesis and development of HCC and the possible identity of RUNX3 gene as an anti-oncogene of HCC.
authors.affiliation: Center of Hepatitis Treatment, 175 Hospital of PLA, Zhangzhou 363000, China. Luyanhui20011213@163.com
authors.forename: Yan-hui
authors.initials: YH
authors.lastname: Lu
authors.forename: Rui-dan
authors.initials: RD
authors.lastname: Zheng
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Bi-fen
authors.initials: BF
authors.lastname: Chen
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Li
authors.forename: Zhi-chuan
authors.initials: ZC
authors.lastname: Lin
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D050677:Core Binding Factor Alpha 3 Subunit; C493729:Runx3 protein, human; D025521:Tumor Suppressor Proteins