title: Serum total antioxidant capacity in patients with multiple sclerosis.
abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). It is characterized by loss of myelin, the fatty tissue that surrounds and protects nerve fibres allowing them to conduct electrical impulses. Recent data indicate that oxidative stress (OS) plays a major role in the pathogenesis of multiple sclerosis (MS). The aim of this study was to estimate level of serum total antioxidative capacity in patients with multiple sclerosis. Our cross-sectional study included 33 patients with MS and 24 age and sex matched control subjects. All our patients had a Poser criteria for definite diagnostic categories of multiple sclerosis. Serum total antioxidant capacity (TAC) was measured by quantitative colorimetric determination, using Total antioxidant Capacity-QuantiCromAntioxidant Assay Kit (BioAssay systems, USA; DTAC-100). Mean serum TAC in multiple sclerosis group of patients was 119.2 mM Trolox equivalents and was significantly lower (p<0.001) compared to the control group of subjects (167.1 mM Trolox equivalents). Our results showed that oxidative stress plays an important role in pathogenesis of multiple sclerosis. This finding, also, suggests the importance of antioxidants in diet and therapy of MS patients.
authors.affiliation: University of Sarajevo, Faculty of Medicine, Institute for Physiological sciences and Biochemistry, Čekaluša, Sarajevo, Bosnia and Herzegovina. fiziologija.09@gmail.com
authors.forename: Almira
authors.initials: A
authors.lastname: Hadžović-Džuvo
authors.forename: Orhan
authors.initials: O
authors.lastname: Lepara
authors.forename: Amina
authors.initials: A
authors.lastname: Valjevac
authors.forename: Nesina
authors.initials: N
authors.lastname: Avdagić
authors.forename: Sabaheta
authors.initials: S
authors.lastname: Hasić
authors.forename: Emina
authors.initials: E
authors.lastname: Kiseljaković
authors.forename: Saida
authors.initials: S
authors.lastname: Ibragić
authors.forename: Azra
authors.initials: A
authors.lastname: Alajbegović
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D001663:Bilirubin / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D012709:Serum Albumin / Q000378:metabolism; D014527:Uric Acid / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D000975:Antioxidants; D012709:Serum Albumin; D014527:Uric Acid; D024502:alpha-Tocopherol; D001205:Ascorbic Acid; D001663:Bilirubin