title: [New therapeutic options in therapy of glioblastoma multiforme].
abstract: Glioblastoma multiforme is one of the most aggressive malignant brain tumours with limited therapeutics options. Standard therapy is maximal surgical resection and adjuvant concurrent chemo-radiotherapy and maintenance therapy with temozolomide. This approach improves median and 5-year survival in comparison with postsurgical radiotherapy alone. Additional predictive and prognostic biomarkers are necessary, especially due to the development of targeted therapy--antibodies and tyrosine kinase inhibitors. These new therapeutic approaches are under intensive investigation. The most promising data currently available are for anti-angiogenic therapies, such as bevacizumab and cediranib. This review presents a summary of the possible role of targeted therapy in the treatment of glioblastoma multiforme.
authors.affiliation: Lékarská fakulta, Masarykova univerzita Brno.
authors.forename: R
authors.initials: R
authors.lastname: Lakomý
authors.forename: P
authors.initials: P
authors.lastname: Burkon
authors.forename: D
authors.initials: D
authors.lastname: Burkonová
authors.forename: R
authors.initials: R
authors.lastname: Jancálek
mesh_terms: D001932:Brain Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D005909:Glioblastoma / Q000628:therapy*; D006801:Humans