title: [Anaphylaxis during anesthesia--especially from neuromuscular blocking agents].
abstract: Among all drugs used for general anesthesia, neuromuscular blocking agents (NMBAs) seem to play a predominant role in the incidence of severe adverse reactions. The overall incidence of perioperative anaphylaxis is estimated at 1 in 10,000-20,000 anesthetic procedures, whereas it is estimated at 1 in 6,500 administrations of NMBAs. After anaphylaxis, allergologic assessment is essential to identify the offending agent and to prevent recurrences. The estimated sensitivity of skin tests for muscle relaxants is approximately 94% to 97%. Prick testing is advised for the diagnosis of the NMBAs responsible for an anaphylactic reaction, and intradermal testing is preferred when investing cross-reaction. The choice of the safest possible anesthetic agents should be based on the result of a rigorously performed allergologic assessment.
authors.affiliation: Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kageyama
authors.forename: Yuka
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Satoru
authors.initials: S
authors.lastname: Hashimoto
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D000768:Anesthesia, General; D006632:Histamine; D006636:Histamine Release; D006801:Humans; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects* / Q000737:chemistry; D059035:Perioperative Period; D011852:Radioallergosorbent Test; D012307:Risk Factors; D055502:Secondary Prevention; D012720:Severity of Illness Index; D012882:Skin Tests; D053802:Tryptases
chemical_list: D009466:Neuromuscular Blocking Agents; D006632:Histamine; D053802:Tryptases