title: Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting.
abstract: The principle objective of this research was to develop and characterize pH-responsive and biocompatible nanogels as a tumor-targeting drug delivery system. The nanogels were self-assembled from chitosan-based copolymers, chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAm). The copolymers were synthesized via free radical copolymerization and characterized for their chemical structure by FT-IR and (1)H NMR. These copolymers could be efficiently loaded with oridonin (ORI) and the characteristics of ORI-loaded nanogels were evaluated. Drug release researches indicated that the ORI-loaded nanogels displayed pH-dependent release behaviors. Based on MTT assay and cellular morphological analysis, the anti-tumor activity of ORI-loaded nanogels was higher at pH 6.5 than at pH 7.4. In conclusion, the obtained nanogels appeared to be of great promise in tumor extracellular pH targeting for ORI.
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua Xilu, Jinan 250012, PR China.
authors.forename: Cunxian
authors.initials: C
authors.lastname: Duan
authors.forename: Dianrui
authors.initials: D
authors.lastname: Zhang
authors.forename: Feihu
authors.initials: F
authors.lastname: Wang
authors.forename: Dandan
authors.initials: D
authors.lastname: Zheng
authors.forename: Lejiao
authors.initials: L
authors.lastname: Jia
authors.forename: Feifei
authors.initials: F
authors.lastname: Feng
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.forename: Yancai
authors.initials: Y
authors.lastname: Wang
authors.forename: Keli
authors.initials: K
authors.lastname: Tian
authors.forename: Fengshan
authors.initials: F
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology; D048271:Chitosan / Q000737:chemistry*; D045786:Diterpenes, Kaurane / Q000008:administration & dosage* / Q000494:pharmacology; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005782:Gels; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; C011959:oridonin; C052970:poly-N-isopropylacrylamide; D048271:Chitosan