title: Ruptured-plaque-like appearance of restenotic tissue following sirolimus-eluting stent implantation: an optical coherence tomography case study.
abstract: A 57-year-old man was admitted for exertional angina pectoris. Coronary angiography showed a 99% stenosis in the left circumflex artery. A sirolimus-eluting stent was deployed in the culprit lesion and excellent angiographic results were obtained. Six-month routine follow-up coronary angiography showed a 90% focal restenosis at the proximal edge of the stent. At this site, optical coherence tomography imaging revealed restenotic tissue with a ruptured-plaque-like appearance overlying the stent struts. Also, a low intensity area suggestive of the presence of a lipid core was evident within the neointimal tissue in another cross section.
authors.affiliation: Kobe University Graduate School of Medicine, Department of Cardiology, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Otake
authors.forename: Junya
authors.initials: J
authors.lastname: Shite
authors.forename: Toshiro
authors.initials: T
authors.lastname: Shinke
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D023903:Coronary Restenosis / Q000473:pathology*; D023921:Coronary Stenosis / Q000628:therapy; D054855:Drug-Eluting Stents; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D020123:Sirolimus; D041623:Tomography, Optical Coherence
chemical_list: D020123:Sirolimus