title: [Coronary stent thrombosis in concurrent clopidogrel and proton pump inhibitor therapy].
abstract: Combined treatment with clopidogrel (CLO) and proton pump inhibitors (PPIs) following coronary stent implantation is often used. CLO as well as PPIs are metabolised by cytochrome P450 isoenzymes, which could theoretically reduce the effect of clopidogrel. Lately, the possibility that such combined therapy may cause an increase in the risk of stent thrombosis has given rise to concern. A review of the literature revealed an attenuation of the antiplatelet effects of clopidogrel in the presence of a PPI in vitro, but evidence on the clinical importance of this finding is conflicting.
authors.affiliation: Kardiologisk Afdeling S, Århus Universitetshospital, Aalborg Sygehus, 9000 Aalborg, Denmark.
authors.forename: Jacob
authors.initials: J
authors.lastname: Juel
authors.forename: Svend Eggert
authors.initials: SE
authors.lastname: Jensen
mesh_terms: D000077144:Clopidogrel; D003328:Coronary Thrombosis / Q000209:etiology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D012307:Risk Factors; D015607:Stents / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors; D054328:Proton Pump Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine