title: Effects of the adenosine deaminase polymorphism and caffeine intake on sleep parameters in a large population sample.
abstract: OBJECTIVE
  To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption.
  
  
  METHODS
  Genetic association study.
  
  
  METHODS
  NA.
  
  
  METHODS
  958 participants who underwent polysomnography and genotyping.
  
  
  METHODS
  NA.
  
  
  RESULTS
  Individuals carrying the A allele who consumed caffeine in the day prior to polysomnography demonstrated higher sleep efficiency and REM sleep percentage, after adjustment for potential confounders. No effect was observed in the absence of caffeine.
  
  
  CONCLUSIONS
  Our data support the role of the ADA G22A polymorphism in sleep, and demonstrate for the first time that caffeine may act as a modulator of its functional effects.
  
  
  BACKGROUND
  Name: Epidemiology of sleep disturbances among adult population of the Sao Paulo City. URL: http://www.clinicaltrials.gov/ct2/show/NCT00596713?term=NCT00596713&rank=1. Number: NCT00596713
authors.affiliation: Departmento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Diego Robles
authors.initials: DR
authors.lastname: Mazzotti
authors.forename: Camila
authors.initials: C
authors.lastname: Guindalini
authors.forename: Renata
authors.initials: R
authors.lastname: Pellegrino
authors.forename: Karina Fonseca
authors.initials: KF
authors.lastname: Barrueco
authors.forename: Rogério
authors.initials: R
authors.lastname: Santos-Silva
authors.forename: Lia Rita Azeredo
authors.initials: LR
authors.lastname: Bittencourt
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
mesh_terms: D000243:Adenosine Deaminase / Q000235:genetics*; D000328:Adult; D000483:Alleles; D002110:Caffeine / Q000494:pharmacology; D004327:Drinking Behavior; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017286:Polysomnography; D012890:Sleep / Q000187:drug effects / Q000235:genetics*
chemical_list: D002110:Caffeine; D000243:Adenosine Deaminase