title: Diagnosis and prognosis evaluation of 1,2-dichloroethane encephalopathy--magnetic resonance imaging combined with diffusion tensor imaging and magnetic resonance spectroscopy study.
abstract: Neuroimaging findings in 1,2-dichloroethane (1,2-DCE) encephalopathy have seldom been reported. We present the comprehensive neuroimaging findings, conventional magnetic resonance imaging (MRI) combined with diffusion tensor imaging (DTI) and 1 H-magnetic resonance spectroscopy ( 1 H-MRS), in a case of 1,2-DCE encephalopathy. On day-4 the signal intensity of the lesions on diffusion-weighted imaging (DWI) was higher than that with T2-weighted imaging (T2WI); mean apparent diffusion coefficient (ADC) values for lesions were lower than control values. On day-20, the mean ADC value was increased gradually, whereas the mean fractional anisotropy (FA) of the lesions was significantly reduced. 1 H-MRS showed reduced ratios of N-acetyl aspartate to creatinine (NAA/Cr) and NAA to choline (NAA/Cho) on day-20 as compared with the control values. Combining conventional MRI with DTI and MRS is valuable in the early diagnosis and prognosis of 1,2-DCE-induced encephalopathy.
authors.affiliation: Department of Radiology, The Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
authors.forename: Fulan
authors.initials: F
authors.lastname: Zhan
authors.forename: Wenbin
authors.initials: W
authors.lastname: Zheng
authors.forename: Lian
authors.initials: L
authors.lastname: Liu
authors.forename: Lingmei
authors.initials: L
authors.lastname: Kong
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005025:Ethylene Dichlorides / Q000633:toxicity*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D020258:Neurotoxicity Syndromes / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D011522:Protons; D011859:Radiography; D055815:Young Adult
chemical_list: D005025:Ethylene Dichlorides; D011522:Protons; D001224:Aspartic Acid; C024565:ethylene dichloride; C000179:N-acetylaspartate