title: Intra uterine growth retardation: association with organochlorine pesticide residue levels and oxidative stress markers.
abstract: Intra uterine growth retardation (IUGR) is a major complication of pregnancy, affecting ∼5% to 10% of newborns. Hexachlorocyclohexane (HCH) is an organochlorine pesticide that consists of eight stereoisomers and γ-isomer is the only isomer that possesses insecticidal activity. The aim of the present study was to analyze the OCP residues in maternal and cord blood of women and to assess the level of oxidative stress markers as well as to establish correlation with OCP levels. Fifty women delivering neonates with low birth weight (IUGR) and equal number of women delivering normal birth weight babies (control) were recruited. We have observed higher levels of γ-HCH and T-HCH and increased oxidative stress markers in IUGR subjects versus control subjects. Significant correlations were also found between HCH isomers and oxidative stress markers in IUGR subjects. In conclusion, our results suggest that higher levels of HCH isomers may be associated with IUGR and increased oxidative stress.
authors.affiliation: Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, University College of Medical Sciences & G.T.B. Hospital University of Delhi, Dilshad Garden, Delhi 110 095, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Pathak
authors.forename: M D
authors.initials: MD
authors.lastname: Mustafa
authors.forename: Tanzeel
authors.initials: T
authors.lastname: Ahmed
authors.forename: Rafat S
authors.initials: RS
authors.lastname: Ahmed
authors.forename: A K
authors.initials: AK
authors.lastname: Tripathi
authors.forename: Kiran
authors.initials: K
authors.lastname: Guleria
authors.forename: B D
authors.initials: BD
authors.lastname: Banerjee
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005317:Fetal Growth Retardation / Q000097:blood / Q000139:chemically induced*; D001556:Hexachlorocyclohexane / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D007194:India; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D016017:Odds Ratio; D018384:Oxidative Stress / Q000187:drug effects*; D010573:Pesticide Residues / Q000009:adverse effects* / Q000097:blood; D010575:Pesticides / Q000009:adverse effects* / Q000097:blood; D011247:Pregnancy; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010573:Pesticide Residues; D010575:Pesticides; D001556:Hexachlorocyclohexane