title: Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture.
abstract: The abundance of a preselection of transcripts involved in inflammation, immunosenescence and stress response was compared between PBMC of healthy aged donors and aged patients in acute phase of heart failure and at recovery. This study identified 22 transcripts differentially abundant in acute phase of heart failure versus healthy aged subjects. Transcripts involved in inflammation and oxidative stress were more abundant. Those associated with T-cell functions were less abundant. The results were compared to two other major acute geriatric issues: infectious diseases and hip fracture. In acute phase, compared to healthy aged subjects, the abundance of 15/22 transcripts was also altered in both geriatric infectious diseases and hip fracture. Many variations had not vanished at the recovery phase. The abundance of CD28, CD69, LCK, HMOX1, TNFRSF1A transcripts, known to be altered in healthy aged versus healthy young subjects, was further affected in acute phase of the three geriatric diseases considered. The transcript levels of BCL2, CASP8, CCL5, DDIT3, EGR3, IL10RB, IL1R2, SERPINB2 and TIMP1 were affected in all three pathological conditions compared to healthy aged, but not versus healthy young subjects. In conclusion, this work provides critical targets for therapeutic research on geriatric heart failure, infectious diseases and hip fracture.
authors.affiliation: Unit of Research on Cellular Biology, NARILIS-Namur Research Institute for Life Sciences, University of Namur (FUNDP), Namur, Belgium.
authors.forename: Thi Kim Duy
authors.initials: TK
authors.lastname: Vo
authors.forename: Marie
authors.initials: M
authors.lastname: de Saint-Hubert
authors.forename: Gabriel
authors.initials: G
authors.lastname: Morrhaye
authors.forename: Patrice
authors.initials: P
authors.lastname: Godard
authors.forename: Vincent
authors.initials: V
authors.lastname: Geenen
authors.forename: Henri J
authors.initials: HJ
authors.lastname: Martens
authors.forename: Florence
authors.initials: F
authors.lastname: Debacq-Chainiaux
authors.forename: Christian
authors.initials: C
authors.lastname: Swine
authors.forename: Olivier
authors.initials: O
authors.lastname: Toussaint
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003141:Communicable Diseases / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006620:Hip Fractures; D006760:Hospitalization; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D015415:Biomarkers