title: Peripheral DNA damage in active pulmonary tuberculosis.
abstract: In pulmonary tuberculosis patients, little is known about peripheral DNA damage, although increased oxidative stress is a well documented entity. Therefore, we aimed to investigate DNA damage along with oxidative status parameters in pulmonary tuberculosis patients. Twenty-seven pulmonary tuberculosis patients and 26 controls were included. DNA damage was assessed by comet assay. Total oxidant and antioxidant status, and oxidative stress index were determined. DNA damage, total oxidant status and oxidative stress index were higher in pulmonary tuberculosis patients than controls (all P < 0.05), while total antioxidant status was lower (P < 0.05). DNA damage was correlated with total oxidant and antioxidant status, and oxidative stress index (r = 0.69, P < 0.05; r = 0.48, P < 0.05, r = -0.47, P < 0.05; respectively) in pulmonary tuberculosis patients. Oxidative stress and DNA damage are increased in pulmonary tuberculosis patients. Increased oxidative stress associated DNA damage may be one of the pathogenetic mechanisms involved in the disorders suggested to be associated with pulmonary tuberculosis.
authors.affiliation: Department of Biochemistry, School of Medicine, Harran University, Sanliurfa, Turkey.
authors.forename: Sahbettin
authors.initials: S
authors.lastname: Selek
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Horoz
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Niyet
authors.initials: N
authors.lastname: Cosar
authors.forename: Faruk
authors.initials: F
authors.lastname: Gunak
authors.forename: Abdurrahim
authors.initials: A
authors.lastname: Kocyigit
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D020552:Comet Assay / Q000379:methods*; D004249:DNA Damage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000503:physiopathology*