title: [Research progress of C terminal propeptide of collagen type II].
abstract: OBJECTIVE
  To review the research progress of C terminal propeptide of collagen type II (CTX-II), a osteoarthritis (OA) biomarker.
  
  
  METHODS
  Domestic and international literature about CTX-II was reviewed extensively and summarized.
  
  
  RESULTS
  CTX-II is investigated broadly and has the best performance of all currently available biomarkers. CTX-II is a truly useful biomarker for early diagnosis, prognosis, and measurement of treatment response in OA.
  
  
  CONCLUSIONS
  Single CTX-II may be not sufficient for early diagnosis and prognosis of OA, so a combination of CTX-II and other biomarkers or diagnosis methods is needed.
authors.affiliation: Department of Orthopedics, Shengjing Hospital, China Medical University, Shenyang Liaoning, 110001, P.R. China. bailh@cmu2h.com
authors.forename: Lunhao
authors.initials: L
authors.lastname: Bai
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Gen
authors.initials: G
authors.lastname: Ba
mesh_terms: D015415:Biomarkers / Q000032:analysis; D024043:Collagen Type II / Q000032:analysis*; D006801:Humans; D010003:Osteoarthritis / Q000175:diagnosis*; D010455:Peptides / Q000032:analysis
chemical_list: D015415:Biomarkers; D024043:Collagen Type II; D010455:Peptides