title: [Therapeutic effect of pelvic methotrexate injection via the posterior fornix for treatment of tubal pregnancy].
abstract: OBJECTIVE
  To evaluate the therapeutic effect and safety of pelvic methotrexate (MTX) injection via the posterior fornix for treatment of tubal pregnancy.
  
  
  METHODS
  Ninety-six patients with tubal pregnancy (mean age 21-40 years) were randomized into 3 groups for treatment with pelvic MTX injection via the posterior fornix+mifepristone+traditional Chinese medicine (experiment group), intramuscular MTX injection+mifepristone+traditional Chinese medicine (control group I), or mifepristone+traditional Chinese medicine (control group II). On days 4 and 7 of the treatment, blood β-HCG of the patients in different groups was detected, and in cases with continuous reduction of blood β-HCG or a reduction by over 15%, β-HCG was checked every week. One week after the treatment, the size of the mass was measured by B-mode ultrasound. The clearance time of β-HCG and the hospital stay of the patients were recorded.
  
  
  RESULTS
  Twenty-nine patients in the experimental group were treated successfully, with a cure rate of 90.6%, which was significantly higher than those in the two control groups (P<0.05). The clearance time of β-HCG and hospital stay were also much shorter in the experimental group (P<0.05).
  
  
  CONCLUSIONS
  Pelvic MTX injection via the posterior fornix is a convenient procedure associated with minimal complications and serves as a good alternative for treatment of tubal pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Dongguan Changping Hospital, Dongguang 523560, China. dongguanyxl@163.com
authors.forename: Xiu-li
authors.initials: XL
authors.lastname: Yang
authors.forename: Yu-ping
authors.initials: YP
authors.lastname: Cao
authors.forename: Zhi-hui
authors.initials: ZH
authors.lastname: Liu
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000328:Adult; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007267:Injections; D008727:Methotrexate / Q000008:administration & dosage*; D015735:Mifepristone / Q000008:administration & dosage; D010388:Pelvis; D008517:Phytotherapy; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*; D014621:Vagina; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D004365:Drugs, Chinese Herbal; D015735:Mifepristone; D008727:Methotrexate