title: Childhood obesity is associated with shorter leukocyte telomere length.
abstract: BACKGROUND
  Obesity in adults is associated with shorter mean leukocyte telomere length (LTL), a marker of biological age that is also associated with age-related conditions including cardiovascular disease and type 2 diabetes. However, studies of childhood obesity and LTL have proved inconclusive.
  
  
  OBJECTIVE
  The objective of the study was to clarify the relationship between telomere length and childhood obesity by measuring the average LTL in a large case-control cohort.
  
  
  METHODS
  LTL was measured in 793 French children aged 2-17 yr (471 with early onset obesity and 322 nonobese controls) using multiplex quantitative real-time PCR. The average LTL in the two groups was compared, and the relationships between telomere length and selected anthropometric and biochemical measurements were examined.
  
  
  RESULTS
  Obese children had a mean LTL that was 23.9% shorter than that of nonobese children (P < 0.0001). Telomere length was inversely associated with age (R = -0.17, P = 0.002 in controls; R = -0.15, P = 0.001 in cases), log weight (R= -0.13, P = 0.017 in controls; R = -0.16, P = 0.0004 in cases), and height (R = -0.15, P = 0.008 in controls; R = -0.17, P = 0.0002 in cases). The mean LTL of girls and boys was not significantly different in either the cases or controls or in the group overall.
  
  
  CONCLUSIONS
  Obese girls and boys have significantly shorter leukocyte telomeres than their nonobese counterparts, a finding that highlights a potentially deleterious impact of early onset obesity on future health.
authors.affiliation: Department of Genomics of Common Disease, School of Public Health, Imperial College London, Burlington-Danes Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom. j.buxton@imperial.ac.uk
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Buxton
authors.forename: Robin G
authors.initials: RG
authors.lastname: Walters
authors.forename: Sophie
authors.initials: S
authors.lastname: Visvikis-Siest
authors.forename: David
authors.initials: D
authors.lastname: Meyre
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
authors.forename: Alexandra I F
authors.initials: AI
authors.lastname: Blakemore
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D004247:DNA / Q000235:genetics; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D009765:Obesity / Q000235:genetics / Q000473:pathology*; D011627:Puberty / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012727:Sex Characteristics; D016615:Telomere / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D008076:Cholesterol, HDL; D004247:DNA; D002784:Cholesterol