title: Inonotus obliquus protects against oxidative stress-induced apoptosis and premature senescence.
abstract: In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senescence.
authors.affiliation: Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea.
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Yun
authors.forename: Jung Woon
authors.initials: JW
authors.lastname: Pahk
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Won Cheol
authors.initials: WC
authors.lastname: Shin
authors.forename: Shin Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Eock Kee
authors.initials: EK
authors.lastname: Hong
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001487:Basidiomycota / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D016922:Cellular Senescence / Q000187:drug effects*; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D008812:Mice, Hairless; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide