title: Hodgkin's and Non-Hodgkin's lymphomas in an indian rural medical institution: comparative clinicopathologic analysis.
abstract: In this prospective, hospital-based two year study, we comparatively evaluated clinicopathologic features of Hodgkin's lymphoma (HL, n = 48) and Non-Hodgkin's lymphoma (NHL, n = 76) in an Indian rural medical institution. A lower median age of onset (28.1 versus 39.9 years) and and higher male to female ratio (3.8:1 versus 3.2:1) were noted for HL compared to NHL. The commonest symptom was neck swelling (58.3% versus 65.8%) while peripheral lymphadenopathy was the commonest sign (83.3% versus 94.7%). The commonest lymph-node group involved was cervical (79.2% versus 79.0%). Bone marrow involvement was lower in HL (8.33% versus 18.4%). The commonest histological subtype was mixed cellularity (45.8%) in HL and diffuse mixed variant (31.6%) in NHL. Most cases presented at advanced stage (54.2% in HL, 71.1 % in NHL). Hence a distinct clinicopathologic profile was noted in HL and NHL that are comparable to other Indian studies but different from Western studies. Recognition of such characteristic features should assist in providing appropriate diagnosis and suitable management in rural communities having limited access to sophisticated medical services.
authors.affiliation: Department of Pathology, RG Kar Medical College and Hospital, Kolkata, West Bengal, India. supriyamed@gmail.com
authors.forename: Sudipta
authors.initials: S
authors.lastname: Chakrabarti
authors.forename: Supriya
authors.initials: S
authors.lastname: Sarkar
authors.forename: Bidyut Krishna
authors.initials: BK
authors.lastname: Goswami
authors.forename: Srikrishna
authors.initials: S
authors.lastname: Mondal
authors.forename: Amitabha
authors.initials: A
authors.lastname: Roy
authors.forename: Shikha
authors.initials: S
authors.lastname: Das
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology*; D006761:Hospitals; D006801:Humans; D007223:Infant; D008206:Lymphatic Diseases; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012424:Rural Population; D055815:Young Adult