title: [Karyotype analysis of qualified sperm donors on preliminary screening].
abstract: OBJECTIVE
  To explore the significance of karyotype analysis in screening sperm donors.
  
  
  METHODS
  From January 1, 2004 to December 31, 2008, a total of 2537 potential sperm donors passed our preliminary screening, and all were routinely karyo-typed via peripheral blood. Follow-ups were conducted on the pregnancy outcome and congenital malformation after artificial insemination with the sperm from the qualified donors.
  
  
  RESULTS
  Among the 2537 qualified sperm donors, 2362 were of the normal karyotype 46, XY and 135 showed polymorphism. Abnormal karyotype was found in 6 cases, and controversial abnormal karyotype in 34.
  
  
  CONCLUSIONS
  Karyotype analysis can reduce the risk of chromosomal disease in neonates from artificial insemination, and genetic counseling for abnormal karyotype sperm donors may help them solve their future reproductive problems.
authors.affiliation: Institute of Reproduction and Stem Cell Engineering, Human Sperm Bank, Citic-Xiangya Hospital of Reproduction and Genetics, Central South University, Changsha, Hunan 410078, China. niehongchuan@gmail.com
authors.forename: Hong-chuan
authors.initials: HC
authors.lastname: Nie
authors.forename: Yue-qiu
authors.initials: YQ
authors.lastname: Tan
authors.forename: Guang-xiu
authors.initials: GX
authors.lastname: Lu
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D025063:Chromosome Disorders / Q000517:prevention & control*; D005820:Genetic Testing; D006061:Gonadal Dysgenesis, 46,XY / Q000235:genetics / Q000517:prevention & control; D006801:Humans; D007621:Karyotyping; D008297:Male; D013074:Sperm Banks; D014019:Tissue Donors; D055815:Young Adult