title: Single nucleotide polymorphisms and mRNA expression for melatonin MT(2) receptor in depression.
abstract: Polymorphisms (rs 4753426 and rs 794837) and expression of the melatonin MT(2) receptor gene were evaluated in 181 patients with recurrent depressive disorder (rDD) and 149 healthy subjects of Polish origin. We found an increased risk for rDD in patients with the C allele and a decreased risk in patients with the T allele (rs4753426). Patients with the AT heterozygote (rs794837) had an increased mRNA level. The significance of the MT(2) receptor gene and the risk of rDD are suggested.
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Medical University of Łódź, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Gałecka
authors.forename: Janusz
authors.initials: J
authors.lastname: Szemraj
authors.forename: Antoni
authors.initials: A
authors.lastname: Florkowski
authors.forename: Piotr
authors.initials: P
authors.lastname: Gałecki
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Bieńkiewicz
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Karbownik-Lewińska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Lewiński
mesh_terms: D000328:Adult; D003863:Depression / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D044123:Receptor, Melatonin, MT2 / Q000235:genetics*; D018709:Statistics, Nonparametric
chemical_list: D012333:RNA, Messenger; D044123:Receptor, Melatonin, MT2