title: L1 Cell adhesion molecule (L1CAM) expression at the cancer invasive front is a novel prognostic marker of pancreatic ductal adenocarcinoma.
abstract: OBJECTIVE
  Pancreatic ductal adenocarcinoma (PDAC) is one of the most extremely aggressive cancers with a poor prognosis after curative resection. L1 cell adhesion molecule (L1CAM) is a 200-220 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily, which has been shown to affect the prognosis of several cancers. No clinicopathological significance of L1CAM expression has been examined at the invasive front of PDAC. In this study, we examined the relationship between L1CAM expression and clinicopathological features in PDAC by immunohistochemistry.
  
  
  METHODS
  One hundred seven surgically resected specimens of PDAC were immunohistochemically examined using a monoclonal antibody against L1CAM.
  
  
  RESULTS
  Positive expression of L1CAM was found in 23 of 107 cases with PDAC. In most cases (21/23), L1CAM expression was localized at the invasive front of the tumor tissue. Positive expression of L1CAM was significantly correlated with the histological grade, lymph node involvement, and distant metastasis. In univariate analysis, a positive expression of L1CAM was associated with short overall survival (P = 0.0002), and this was significant in multivariate analysis (P = 0.009).
  
  
  CONCLUSIONS
  L1CAM could play an important role in the invasive process in vivo, and is thought to be a good indicator of prognosis in PDAC.
authors.affiliation: Department of Pathology Hirosaki University School of Medicine, Hirosaki, Aomori, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Tsutsumi
authors.forename: Satoko
authors.initials: S
authors.lastname: Morohashi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kudo
authors.forename: Harue
authors.initials: H
authors.lastname: Akasaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogasawara
authors.forename: Masashi
authors.initials: M
authors.lastname: Ono
authors.forename: Kaori
authors.initials: K
authors.lastname: Takasugi
authors.forename: Keinosuke
authors.initials: K
authors.lastname: Ishido
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hakamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D039842:Neural Cell Adhesion Molecule L1 / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D016016:Proportional Hazards Models; D012737:Sex Factors
chemical_list: D014408:Biomarkers, Tumor; D039842:Neural Cell Adhesion Molecule L1