title: The human studies database project: federating human studies design data using the ontology of clinical research.
abstract: Human studies, encompassing interventional and observational studies, are the most important source of evidence for advancing our understanding of health, disease, and treatment options. To promote discovery, the design and results of these studies should be made machine-readable for large-scale data mining, synthesis, and re-analysis. The Human Studies Database Project aims to define and implement an informatics infrastructure for institutions to share the design of their human studies. We have developed the Ontology of Clinical Research (OCRe) to model study features such as design type, interventions, and outcomes to support scientific query and analysis. We are using OCRe as the reference semantics for federated data sharing of human studies over caGrid, and are piloting this implementation with several Clinical and Translational Science Award (CTSA) institutions.
authors.affiliation: Univ. of California San Francisco, CA;
authors.forename: Ida
authors.initials: I
authors.lastname: Sim
authors.forename: Simona
authors.initials: S
authors.lastname: Carini
authors.forename: Samson
authors.initials: S
authors.lastname: Tu
authors.forename: Rob
authors.initials: R
authors.lastname: Wynden
authors.forename: Brad H
authors.initials: BH
authors.lastname: Pollock
authors.forename: Shamim A
authors.initials: SA
authors.lastname: Mollah
authors.forename: Davera
authors.initials: D
authors.lastname: Gabriel
authors.forename: Herbert K
authors.initials: HK
authors.lastname: Hagler
authors.forename: Richard H
authors.initials: RH
authors.lastname: Scheuermann
authors.forename: Harold P
authors.initials: HP
authors.lastname: Lehmann
authors.forename: Knut M
authors.initials: KM
authors.lastname: Wittkowski
authors.forename: Meredith
authors.initials: M
authors.lastname: Nahm
authors.forename: Suzanne
authors.initials: S
authors.lastname: Bakken