title: Predictors of nosocomial bloodstream infections in older adults.
abstract: OBJECTIVE
  To identify predictors and construct a prediction model for nosocomial bloodstream infection (BSI) in older adults.
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  Hospitals belonging to the Duke Infection Control Outreach Network.
  
  
  METHODS
  Patients age 65 and older with a nosocomial BSI and matched uninfected controls.
  
  
  METHODS
  Multiple variables were captured and compared between groups. Independent predictors were identified using conditional logistic regression. A prediction model and score was constructed.
  
  
  RESULTS
  Eight hundred thirty cases were compared with 830 controls. Eighty-one percent of nosocomial BSIs were catheter related (CRBSI). Methicillin-resistant Staphylococcus aureus (MRSA) was the most common pathogen isolated (23%). Independent predictors of nosocomial BSI in older adults were male sex, obesity, low McCabe score on admission, presence of a central line at admission, gastrostomy at admission, recent surgery, and urinary incontinence. A prediction model score greater than 11 (total possible score 23) was predictive of infection.
  
  
  CONCLUSIONS
  MRSA is a common cause of CRBSI in older adults. Male sex, obesity, the presence of a central line, a gastrostomy tube, and urinary incontinence at the time of admission were independent predictors of BSI in hospitalized older adults. The prediction model constructed in this study should be validated prospectively in a different cohort.
authors.affiliation: Division of Infectious Diseases, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.
authors.forename: Keith S
authors.initials: KS
authors.lastname: Kaye
authors.forename: Dror
authors.initials: D
authors.lastname: Marchaim
authors.forename: Ting-Yi
authors.initials: TY
authors.lastname: Chen
authors.forename: Teena
authors.initials: T
authors.lastname: Chopra
authors.forename: Deverick J
authors.initials: DJ
authors.lastname: Anderson
authors.forename: Yong
authors.initials: Y
authors.lastname: Choi
authors.forename: Richard
authors.initials: R
authors.lastname: Sloane
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Schmader
mesh_terms: D000368:Aged; D016470:Bacteremia / Q000453:epidemiology / Q000209:etiology*; D002404:Catheterization / Q000009:adverse effects*; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology