title: Progressive encephalopathy with cerebral oedema and infarctions associated with valproate and diazepam overdose.
abstract: Valproic Acid (VPA) in overdose is known to cause encephalopathy with or without cerebral odema, hyperammonaemia, hepatotoxicity, bone marrow suppression and non gap acidosis. Most of these conditions are reversible. We report a 45-year-old man who suffered permanent disability from the non reversible effects of cerebral odema and infarctions associated with Valproate overdose which would have been aggravated by Diazepam. This patient's presentation emphasizes the role of early detection and therapy of cerebral odema in Valproate and Diazepam overdose.
authors.affiliation: Neurology Department, Frankston Hospital, PO Box 52, Frankston, Victoria 3199, Australia. jayantha.rupasinghe@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Rupasinghe
authors.forename: M
authors.initials: M
authors.lastname: Jasinarachchi
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects* / Q000506:poisoning; D001929:Brain Edema / Q000209:etiology*; D020520:Brain Infarction / Q000209:etiology*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003128:Coma / Q000209:etiology*; D003975:Diazepam / Q000009:adverse effects* / Q000506:poisoning; D062787:Drug Overdose; D015600:Glasgow Coma Scale; D006501:Hepatic Encephalopathy / Q000209:etiology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000506:poisoning; D008297:Male; D014635:Valproic Acid / Q000009:adverse effects* / Q000506:poisoning
chemical_list: D018692:Antimanic Agents; D006993:Hypnotics and Sedatives; D014635:Valproic Acid; D003975:Diazepam