title: Effects of kainic acid lesions of the cerebellar interpositus and dentate nuclei on amygdaloid kindling in rats.
abstract: Some neurophysiological studies suggest that the cerebellum could participate in epileptic activity. Therefore, to study the participation of the main efferent projections from the cerebellum to the forebrain, we injected small doses of kainic acid (KA) into the deep cerebellar nuclei to selectively injure neighboring cells while avoiding fiber lesions. Uninjured fibers were confirmed using histological findings and by assessing the number of cells in the main cerebellar afferents, compared with controls. Under such conditions, we found that dentate and interpositus nuclei lesions interfere with seizure expression, both at early kindling acquisition and at the kindled stage. We hypothesize that the cerebellar effect on epilepsy drives skeletal motor responses, mainly in generalized seizures when the thalamus and neocortex are affected.
authors.affiliation: Instituto Nacional De Neurología Y Neurocirugía M. V. S. Insurgentes sur 3877 col. La fama, Mexico 14269, DF, Mexico.
authors.forename: Carmen
authors.initials: C
authors.lastname: Rubio
authors.forename: Verónica
authors.initials: V
authors.lastname: Custodio
authors.forename: Edith
authors.initials: E
authors.lastname: González
authors.forename: Socorro
authors.initials: S
authors.lastname: Retana-Márquez
authors.forename: Marisol
authors.initials: M
authors.lastname: López
authors.forename: Carlos
authors.initials: C
authors.lastname: Paz
mesh_terms: D000679:Amygdala / Q000473:pathology / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002529:Cerebellar Nuclei / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D004569:Electroencephalography; D007608:Kainic Acid / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007608:Kainic Acid