title: Microwave promoted C6-alkylation of purines through S(N)Ar-based reaction of 6-chloropurines with 3-alkyl-acetylacetone.
abstract: C6-Alkylated purine analogues were obtained in good to excellent isolated yields by S(N)Ar reaction of 6-chloropurine derivatives with 3-alkyl-acetylacetone. 3-Alkyl-acetylacetones were employed as alkylating agents and C6-alkylated purines were obtained highly selectively within short reaction time under microwave irradiation conditions. This work is complementary to the classical coupling reactions for the synthesis of C6-alkylated purine analogues.
authors.affiliation: College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang 453007, Henan, China. guohm518@hotmail.com
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Niu
authors.forename: Dong-Chao
authors.initials: DC
authors.lastname: Wang
authors.forename: Zhi-Liang
authors.initials: ZL
authors.lastname: Chu
authors.forename: Gui-Rong
authors.initials: GR
authors.lastname: Qu
mesh_terms: D000478:Alkylation; D002244:Carbon / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D010422:Pentanones / Q000737:chemistry*; D011687:Purines / Q000737:chemistry*
chemical_list: D010422:Pentanones; D011687:Purines; C008790:acetylacetone; D002244:Carbon; C079308:6-chloropurine