title: Primary cardiac synovial sarcoma: a case report and literature review.
abstract: Primary cardiac synovial sarcoma is a rare disease. A 51-year-old man visited our hospital with the chief complaint of palpitations and shortness of breath while exercising. Copious bloody pericardial effusion and a multicystic intrapericardial tumor were detected. A primary cardiac malignant tumor was suspected, an open-chest tumor resection was performed with the objectives of diagnosis and treatment. Histologically, the tumor cells were uniformly spindle-shaped with an ovoid or oval nucleus, they had proliferated in fascicular fashion. In addition myxoid degeneration, a hemangiopericytomatous vascular pattern and pseudorosette formation were seen in some areas of the tumor. Based on the histopathological and immunohistochemical findings and reverse transcription polymerase chain reaction detection of SS18-SSX1 fusion transcripts, a monophasic fibrous type synovial sarcoma was diagnosed. Postoperative radiation therapy was administered and there had been no recurrence 9 months after the surgery.
authors.affiliation: Department of Surgical Pathology Cardiovascular Medicine Cardiovascular Surgery Radiology, Toho University Ohashi Medical Center, Tokyo, Japan. tyuki@med.toho-u.ac.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yokouchi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hiruta
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Oharaseki
authors.forename: Fumie
authors.initials: F
authors.lastname: Ihara
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
authors.forename: Shingo
authors.initials: S
authors.lastname: Ito
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yamashita
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Ozaki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Gomi
authors.forename: Kei
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000199:Actins / Q000378:metabolism; D018206:Angiolipoma / Q000175:diagnosis; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D006338:Heart Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008067:Lipoma / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D020286:Pericytes / Q000378:metabolism / Q000473:pathology*; D018714:Radiotherapy, Adjuvant; D013584:Sarcoma, Synovial / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013848:Thigh
chemical_list: D000199:Actins; D018952:Antigens, CD34; D014408:Biomarkers, Tumor