title: [Efficiency of using cycloferon as part of combined therapy for chronic hepatitis C (a review of multicenter clinical trials)].
abstract: The results of a study of the efficiency of treatment in patients with chronic hepatitis C conducted in a complex of multicenter clinical trials of the impact of various antiviral therapy regimens including the interferon genesis inductor cycloferon are reviewed. Four hundred and seventy-eight patients with hepatitis C virus infection were followed up. The study has demonstrated that the incorporation of cycloferon into the standard treatment regimen, which is manifested by the effect of drug synergism, by producing antiviral, immunomodulating, and antifibrotic effects, is a promising pharmacotherapy for chronic hepatitis C. This treatment is economically sound, reduces the incidence and degree of adverse reactions and increases the quality of life in the patients.
authors.forename: T V
authors.initials: TV
authors.lastname: Sologub
authors.forename: M G
authors.initials: MG
authors.lastname: Romantsev
authors.forename: A A
authors.initials: AA
authors.lastname: Shul'diakov
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Lin'kova
authors.forename: V G
authors.initials: VG
authors.lastname: Radchenko
authors.forename: A L
authors.initials: AL
authors.lastname: Kovalenko
mesh_terms: D000166:Acridines / Q000008:administration & dosage / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007369:Interferon Inducers / Q000008:administration & dosage / Q000627:therapeutic use*; D015337:Multicenter Studies as Topic; D016896:Treatment Outcome
chemical_list: D000166:Acridines; D000998:Antiviral Agents; D007369:Interferon Inducers; C026430:10-carboxymethyl-9-acridanone