title: Coagulation studies.
abstract: Disseminated intravascular coagulation (DIC) is a complex acquired, coagulopathy resulting from excessive thrombin formation. Abnormal tissue factor (TF) expression is a major mechanism initiating DIC in many disorders, including obstetric complications, sepsis, cancer, and trauma. Numerous laboratory tests are available to monitor DIC, but most patients can be adequately managed using only routine hemostasis screening tests, and assays for fibrinogen and D-dimers. Treatment of DIC should focus on reversing the underlying disorder that initiated the coagulopathy. Novel treatments are being investigated for the treatment of DIC; many of these experimental modalities target the excessive TF activity that characterizes DIC.
authors.affiliation: Department of Pediatrics, Sophia Children's Hospital, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Hazelzet
authors.forename: C E
authors.initials: CE
authors.lastname: Hack
authors.forename: R
authors.initials: R
authors.lastname: de Groot