title: [Vaginal oestrogen therapy in women with hormone-sensitive breast cancer].
abstract: Vaginal atrophy is a common problem in women who have previously been treated for breast cancer. Endocrine therapy plays an essential role in the treatment of breast cancer. Systemic hormonal treatment is contraindicated. Topical oestrogens are an effective treatment for vaginal atrophy, but are poorly studied in this group of patients. Physicians are reluctant to recommend it because of the potential increase in the risk of recurrence. The sparse data available suggest that vaginal oestrogen may be used relatively safely by women who are in tamoxifen treatment, but should not be used by women who receive aromatase inhibitor treatment.
authors.affiliation: Klinisk Farmakologisk Afdeling, Århus Universitetshospital, 8000 Aarhus C, Denmark. ann.m.bak@gmail.com
authors.forename: Ann Mosegaard
authors.initials: AM
authors.lastname: Bak
authors.forename: Britt Elmedal
authors.initials: BE
authors.lastname: Laursen
authors.forename: Jørgen
authors.initials: J
authors.lastname: Rungby
authors.forename: Birgitte
authors.initials: B
authors.lastname: Brock
mesh_terms: D000282:Administration, Intravaginal; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects / Q000627:therapeutic use; D047072:Aromatase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D001284:Atrophy; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism; D000075202:Contraindications; D004965:Estrogen Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008593:Menopause; D009364:Neoplasm Recurrence, Local / Q000139:chemically induced; D013629:Tamoxifen / Q000009:adverse effects / Q000627:therapeutic use; D014621:Vagina / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D004965:Estrogen Antagonists; D004967:Estrogens; D013629:Tamoxifen