title: Osteonecrosis in childhood ALL.
abstract: Kawedia et al report a 71% incidence of osteonecrosis (ON) in a cohort of children and young adult acute lymphoblastic leukemia (ALL) patients who underwent routine magnetic resonance imaging (MRI) screening at various time points on study. A majority of cases were asymptomatic. Older age, increased treatment intensity, low serum albumen, elevated lipid levels, and decreased dexamethasone clearance were risk factors associated with an increased incidence of osteonecrosis.
authors.affiliation: University of Chicago Medical Center.
authors.forename: James B
authors.initials: JB
authors.lastname: Nachman