title: Age-related changes in iliac crest cortical width and porosity: a histomorphometric study.
abstract: Although age-related changes in cancellous bone structure in human are relatively well characterized, few studies have addressed changes in cortical bone. We have investigated age-related changes in iliac crest bone biopsy specimens from 54 normal subjects, 23 men and 31 women, aged 18-90 years. A significant decrease in cortical width and area was seen (P =0.002 and <0.001 respectively), with no difference between sexes. Haversian canal density increased significantly with age by approximately 9% per decade (P = 0.032) but Haversian canal area tended to be lower, resulting in no overall age-related difference in cortical porosity. Haversian canal area was significantly higher in the endosteal section than in the periosteal section of the cortex (P = 0.019) but the Haversian canal density was lower, resulting in similar overall porosity in the two sections. In conclusion, our results demonstrate an age-related decrease in iliac crest cortical width in men and women and an increase in Haversian canal density, but no overall change in cortical porosity.
authors.affiliation: Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
authors.forename: Shobna
authors.initials: S
authors.lastname: Vedi
authors.forename: Stephen
authors.initials: S
authors.lastname: Kaptoge
authors.forename: J E
authors.initials: JE
authors.lastname: Compston
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015519:Bone Density; D005260:Female; D006801:Humans; D007085:Ilium / Q000473:pathology* / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D055815:Young Adult