title: [Encounter of cancer cells with bone. Molecular mechanism of cancer-induced bone pain].
abstract: Bone pain is the most common complications in bone metastases, causing increased morbidity and undermining quality of life (QOL) in patients. It has been considered that algesic factors produced by tumor tissues and nerve injury are involved in pain progression. However, the molecular mechanisms of bone pain are still complex and not fully understood. Recent studies show that acidic microenvironment created in bone metastasis is relevant to pain signal through the activation of acid-sensing nociceptor in sensory neurons. These elucidations might be lead to the development of therapeutic approaches for cancer pain.
authors.affiliation: Department of Biochemistry, Osaka University Graduate School of Dentistry.
authors.forename: Masako
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Kenji
authors.initials: K
authors.lastname: Hata
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yoneda
mesh_terms: D062565:Acid Sensing Ion Channels; D000818:Animals; D001859:Bone Neoplasms / Q000150:complications* / Q000556:secondary*; D001842:Bone and Bones / Q000294:innervation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D058990:Molecular Targeted Therapy; D009419:Nerve Tissue Proteins / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000209:etiology* / Q000235:genetics*; D059408:Pain Management; D011788:Quality of Life; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000502:physiology; D011984:Sensory Receptor Cells / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology; D050916:TRPV Cation Channels / Q000502:physiology
chemical_list: D062565:Acid Sensing Ion Channels; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D018015:Receptors, Calcitonin Gene-Related Peptide; D015222:Sodium Channels; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human