title: Endothelium-dependent delivery of insulin to muscle interstitium.
abstract: Insulin contributes to skeletal muscle glucose uptake by increasing blood flow and recruiting perfused capillaries. In this issue of Cell Metabolism, Kubota et al. (2011) show that deletion of IRS-2 in endothelial cells in mice causes impaired transcapillary insulin transport, decreased insulin-stimulated glucose uptake in muscle, and mild glucose intolerance.
authors.affiliation: Research Division, Joslin Diabetes Center, Boston, MA 02215, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Rask-Madsen
authors.forename: George L
authors.initials: GL
authors.lastname: King