title: Early prediction of postmeningitic hearing loss in children using magnetic resonance imaging.
abstract: OBJECTIVE
  To determine whether early gadolinium-enhanced magnetic resonance imaging (GdMRI) can reliably detect meningitic labyrinthitis and thereby predict which children are at high risk for hearing loss. Permanent sensorineural hearing loss (SNHL) remains a common sequela of bacterial meningitis, and early diagnosis of the associated suppurative labyrinthitis can be difficult, especially in critically ill, sedated patients and young children.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Tertiary pediatric hospital.
  
  
  METHODS
  Twenty-three survivors of bacterial meningitis (median age, 15 months [range, 3 months-14 years]) who had undergone brain GdMRI during the acute disease and had subsequent ear-specific audiometric data.
  
  
  METHODS
  Blinded to disease and outcome, a neuroradiologist rated the relative enhancement of each cochlea on T1-weighted images using a 4-point scale. Scores were then correlated with the degree of hearing loss on subsequent testing.
  
  
  RESULTS
  Sensorineural hearing loss occurred in 15 of 46 ears (8 of 23 patients). Enhancement on GdMRI was detected in 13 of the 15 ears that later developed SNHL but was absent in all 31 unaffected ears. Thus, GdMRI was 87% sensitive and 100% specific for predicting which ears would develop permanent SNHL. In the subgroup with pneumococcal meningitis (n = 15), GdMRI was 100% sensitive and 100% specific. Labyrinthine enhancement was detectable as early as 1 day after diagnosis.
  
  
  CONCLUSIONS
  Gadolinium-enhanced MRI detected meningitic labyrinthitis at early stages and accurately predicted which patients would later develop hearing loss.
authors.affiliation: Division of Pediatric Otolaryngology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Kopelovich
authors.forename: John A
authors.initials: JA
authors.lastname: Germiller
authors.forename: Adrienne M
authors.initials: AM
authors.lastname: Laury
authors.forename: Samir S
authors.initials: SS
authors.lastname: Shah
authors.forename: Avrum N
authors.initials: AN
authors.lastname: Pollock
mesh_terms: D000293:Adolescent; D001299:Audiometry; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D003287:Contrast Media; D042241:Early Diagnosis; D005260:Female; D019786:Gadolinium DTPA; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007223:Infant; D007762:Labyrinthitis / Q000150:complications* / Q000175:diagnosis* / Q000382:microbiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications* / Q000175:diagnosis* / Q000382:microbiology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA