title: Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects.
abstract: Roots of Morinda citrifolia (Noni or Yor in Thai) have been used traditionally for thousands of years to treat chronic diseases such as cancer and heart disease. In this study, three new anthraquinones together with 15 known compounds were isolated from the roots of M. citrifolia (Rubiaceae). Their structures were established by spectroscopic methods, particularly 1D and 2D NMR techniques. Six known compounds, together with two new compounds (2 and 3) showed significant inhibitory effects on the proliferation of human lung and colon cancer cells.
authors.affiliation: Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA.
authors.forename: Lishuang
authors.initials: L
authors.lastname: Lv
authors.forename: Huadong
authors.initials: H
authors.lastname: Chen
authors.forename: Chi-Tang
authors.initials: CT
authors.lastname: Ho
authors.forename: Shengmin
authors.initials: S
authors.lastname: Sang
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D032066:Morinda / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000880:Anthraquinones