title: Allergic contact dermatitis due to diclofenac sodium in eye drops.
abstract: Eyelid dermatitis and/or periocular dermatitis (ED/PD) is commonly seen in a variety of skin diseases such as seborrheic dermatitis, atopic dermatitis and psoriasis, but is most often associated with allergic contact dermatitis (ACD). Here, a case of ACD in an 82-year-old man is described; he used 0.1% diclofenac sodium eye drops and exhibited pruritic erythema on the eyelids. Patch test for diclofenac sodium eye drops was positive. Further patch tests revealed a positive reaction to diclofenac sodium (monosodium 2-[2, 6-dichlorophenylamino] phenylacetate), which was the main component in the eye drop medicine. Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID), and is frequently used in everyday oral medications, topical ointments, gel agents and eye drops. Case reports on ACD caused by diclofenac sodium eye drops are extremely rare. Nevertheless, it is necessary to consider ACD due to diclofenac sodium when a patient with ED/PD has a history of use of diclofenac sodium eye drops.
authors.affiliation: Division of Dermatology, Department of Organ-related Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Uehara, Nishihara Chuo Dermatological Office, Matsuo, Naha, Okinawa, Japan. hihuka@jim.u-ryukyu.ac.jp
authors.forename: Hitona
authors.initials: H
authors.lastname: Miyazato
authors.forename: Sayaka
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Taira
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Asato
authors.forename: Yu-Ichi
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uezato
mesh_terms: D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D019557:Dermatitis, Perioral / Q000139:chemically induced*; D004008:Diclofenac / Q000009:adverse effects*; D005141:Eyelid Diseases / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions / Q000009:adverse effects*; D010328:Patch Tests
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D004008:Diclofenac