title: Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction.
abstract: The rhizome of Dioscorea japonica is a food and medicinal source known as 'San Yak' in Korea. Two new furostanol saponins, coreajaponins A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of D. japonica. Their structures were determined by spectroscopic methods, including 1D and 2D NMR techniques, HRMS, and chemical methods. Nerve growth factor (NGF), a crucial factor for neuronal survival and differentiation, can potentially improve neurodegenerative diseases and diabetic polyneuropathy. We evaluated the effects of isolates (1-12) on NGF induction in a C6 rat glioma cell line. Coreajaponin B (2) upregulated NGF content without significant cell toxicity, as did 6, 8, 9, and 11.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon, Gyeonggi-do 440-746, Republic of Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Min Ah
authors.initials: MA
authors.lastname: Kim
authors.forename: Eunjung
authors.initials: E
authors.lastname: Moon
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Sang Zin
authors.initials: SZ
authors.lastname: Choi
authors.forename: Mi Won
authors.initials: MW
authors.lastname: Son
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D002240:Carbohydrate Sequence; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D027742:Dioscorea / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D020932:Nerve Growth Factor / Q000096:biosynthesis*; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D012503:Saponins; D020932:Nerve Growth Factor