title: Is there a role for aerosol nasal sprays in the treatment of allergic rhinitis: a white paper.
abstract: This White Paper presents the Consensus Statements derived from a Special Issues Board (SIB) held in Chicago, IL, in October 2010. The SIB was convened to address the question of whether there is a need for both aerosol and aqueous intranasal steroids (INSs) in the treatment of allergic rhinitis (AR). The faculty reviewed the published record of efficacy and safety of aerosol and aqueous INSs, as well as patient and physician satisfaction and preferences for currently available INSs, and burden of disease. Agreement on unmet needs also included the practice experience of the faculty and their colleagues. The body of evidence indicates that INSs are equally effective and well tolerated for most patients. However, differences exist among current aqueous formulations as well as between these products and their aerosol antecedents, based on the properties of the nasal spray. Aerosol formulations, although no longer available, may be preferred for some patients with specific pathophysiology and may be preferred by some patients based on sensory perception. There are good reasons to expand the currently available options of INSs by having both aerosol and aqueous formulations.
authors.affiliation: Department of Medicine, University of Wisconsin, Madison, USA. allan_luskin@hotmail.com
authors.forename: Allan T
authors.initials: AT
authors.lastname: Luskin
authors.forename: Michael S
authors.initials: MS
authors.lastname: Blaiss
authors.forename: Judith R
authors.initials: JR
authors.lastname: Farrar
authors.forename: Russell
authors.initials: R
authors.lastname: Settipane
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Hayden
authors.forename: Stuart
authors.initials: S
authors.lastname: Stoloff
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chadwick
authors.forename: M Jennifer
authors.initials: MJ
authors.lastname: Derebery
authors.forename: Mary P
authors.initials: MP
authors.lastname: Ettari
authors.forename: Susan
authors.initials: S
authors.lastname: Luskin
authors.forename: Robert
authors.initials: R
authors.lastname: Naclerio
mesh_terms: D000281:Administration, Intranasal; D000336:Aerosols / Q000627:therapeutic use; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical; D002641:Chicago; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D059085:Nasal Sprays; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D013256:Steroids / Q000627:therapeutic use; D014867:Water / Q000737:chemistry
chemical_list: D000336:Aerosols; D018926:Anti-Allergic Agents; D005938:Glucocorticoids; D059085:Nasal Sprays; D013256:Steroids; D014867:Water