title: Effect of atrial septostomy on the survival of patients with severe pulmonary arterial hypertension.
abstract: Atrial septostomy (AS) is a palliative treatment for right ventricular failure from severe pulmonary arterial hypertension (PAH). We sought to investigate the effect of AS, alone or combined with PAH-specific pharmacotherapy, on the survival of patients with PAH. We performed a retrospective analysis of the functional and haemodynamic changes in patients with PAH following AS, and long-term survival characteristics for the whole group and separately for the subgroup who received post-procedural pharmacotherapy. 50 procedures performed in 34 patients (mean ± SD age 35 ± 10 yrs) resulted in haemodynamic and symptomatic improvement in most of the patients. Only one (2%) procedure-related death occurred. Due to spontaneous closure of the defect, AS was repeated in 10 patients. In 21 patients, AS was the only form of treatment, while 11 received additional pharmacotherapy after AS. During follow-up (58.5 ± 38 months), 21 patients died; median survival of the group was 60 months (95% CI 43-77 months). Median survival for patients on pharmacotherapy additional to AS was 83 months (95% CI 57-109 months), which was better than that for patients with AS alone (53 months, 95% CI 39-67 months) (log-rank 6.52; p = 0.010). In selected patients with PAH, AS is a safe and effective intervention that exerts a beneficial impact on long-term survival. Survival appears to be improved when AS is combined with PAH-specific pharmacotherapy.
authors.affiliation: Cardiopulmonary Dept, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No 1, Colonia Sección XVI, Tlalpan, 14080 México, DF México, Mexico. julio.sandoval@cardiologia.org.mx
authors.forename: J
authors.initials: J
authors.lastname: Sandoval
authors.forename: J
authors.initials: J
authors.lastname: Gaspar
authors.forename: H
authors.initials: H
authors.lastname: Peña
authors.forename: L E
authors.initials: LE
authors.lastname: Santos
authors.forename: J
authors.initials: J
authors.lastname: Córdova
authors.forename: K
authors.initials: K
authors.lastname: del Valle
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez
authors.forename: T
authors.initials: T
authors.lastname: Pulido
mesh_terms: D000328:Adult; D054087:Atrial Septum / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000379:methods / Q000401:mortality; D003131:Combined Modality Therapy; D065627:Familial Primary Pulmonary Hypertension; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult