title: Chemically targeting the emergent properties of a chaperone complex.
abstract: In this issue, Chang et al. (2011) report a small molecule screen against the reconstituted DnaK-DnaJ-GrpE chaperone cycle. Through this approach, they identified myricetin as an inhibitor of DnaJ-stimulated DnaK ATPase activity, indicating the potential for their screening approach to identify modulators of emergent properties of protein complexes.
authors.affiliation: Department of Molecular and Experimental Medicine and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Genereux
authors.forename: R Luke
authors.initials: RL
authors.lastname: Wiseman