title: Absence of porcine circovirus type 1 (PCV1) and high prevalence of PCV 2 exposure and infection in swine finisher herds.
abstract: Porcine circovirus (PCV) appeared in 1974 as an unidentified, innocuous viral inhabitant of cell cultures and pigs. Today PCV1 is a contaminant of some human vaccines, and PCV2 is a major pathogen of swine. PCV1 is reportedly ubiquitous in swine but nonpathogenic. Since the interplay of PCV1 and PCV2 in swine might explain variable disease results and shed light on the potential for human exposure, we analyzed in depth the prevalence of PCV1 and PCV2 infection and exposure in the U.S. finishing swine herd. Over 82% of sera from 185 farms were positive for PCV2 by PCR, whereas only 2.4% were positive for PCV1. More than 80% of PCV2 DNA-positive swine were also positive for anti-PCV2 antibodies. PCV1 was only rarely present. Exposure of swine, and therefore humans via pigs, to PCV1 is negligible. We conclude that PCV2 causes a persistent infection in pigs and that PCV1 is absent or rare in swine.
authors.affiliation: Department of Veterinary & Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN 55108, USA.
authors.forename: Sumathy
authors.initials: S
authors.lastname: Puvanendiran
authors.forename: Suzanne
authors.initials: S
authors.lastname: Stone
authors.forename: Wanqin
authors.initials: W
authors.lastname: Yu
authors.forename: Craig R
authors.initials: CR
authors.lastname: Johnson
authors.forename: Juan
authors.initials: J
authors.lastname: Abrahante
authors.forename: Liza Garcia
authors.initials: LG
authors.lastname: Jimenez
authors.forename: Theodor
authors.initials: T
authors.lastname: Griggs
authors.forename: Charles
authors.initials: C
authors.lastname: Haley
authors.forename: Bruce
authors.initials: B
authors.lastname: Wagner
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murtaugh
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D002213:Capsid / Q000276:immunology / Q000821:virology; D018173:Circoviridae Infections / Q000453:epidemiology*; D017925:Circovirus / Q000254:growth & development* / Q000472:pathogenicity*; D004279:DNA, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D016014:Linear Models; D010957:Plasmids; D016133:Polymerase Chain Reaction; D015995:Prevalence; D017422:Sequence Analysis, DNA; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral