title: Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men.
abstract: The renin-angiotensin system is a major regulatory system of cardiovascular and renal function. Recently, (pro)renin receptor [(P)RR] was identified as new component of the renin-angiotensin system. The IVS5+169C>T polymorphism of the (P)RR gene was shown to be associated with blood pressure (BP) in Japanese men, but no data are available for Caucasians. Hence, we genotyped the IVS5+169C>T polymorphism of the (P)RR gene in 266 Caucasian men with normal or mildly elevated BP and without any medication. Office BP was measured according to current guidelines. Office and resting systolic BP was lower in C-allele than in T-allele carriers (P<0.05) of the (P)RR gene, with no difference in diastolic BP and heart rate. Serum aldosterone was also lower in C-allele than in T-allele carriers (P<0.05). These findings indicate that C-allele carriers have lower systolic BP than T-allele carriers. Thus, our data suggest that (P)RR influences BP regulation in Caucasian men, potentially through altered aldosterone release.
authors.affiliation: Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Krankenhausstrasse 12, Erlangen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Ott
authors.forename: Markus P
authors.initials: MP
authors.lastname: Schneider
authors.forename: Christian
authors.initials: C
authors.lastname: Delles
authors.forename: Markus P
authors.initials: MP
authors.lastname: Schlaich
authors.forename: Karl F
authors.initials: KF
authors.lastname: Hilgers
authors.forename: Roland E
authors.initials: RE
authors.lastname: Schmieder
mesh_terms: D000450:Aldosterone / Q000378:metabolism; D001794:Blood Pressure / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D005787:Gene Frequency; D005838:Genotype; D006439:Hemodynamics; D006801:Humans; D006937:Hypercholesterolemia / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*; D044465:White People / Q000235:genetics*; D000093342:Prorenin Receptor
chemical_list: D011956:Receptors, Cell Surface; D000450:Aldosterone; D000093342:Prorenin Receptor