title: Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts.
abstract: The effects of schisandrin B (Sch B) and its analogs on solar irradiation-induced oxidative injury were examined in BJ human fibroblasts. Sch B and schisandrin C (Sch C) increased cellular reduced glutathione (GSH) level and protected against solar irradiation-induced oxidative injury. The photoprotection was paralleled by decreases in the elastases-type protease activity and matrix-metalloproteinases-1 expression in solar-irradiated fibroblasts. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production. The results suggest that by virtue of its pro-oxidant action and the subsequent glutathione antioxidant response, Sch B or Sch C may offer the prospect of preventing skin photo-aging.
authors.affiliation: Department of Biochemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Po Yee
authors.initials: PY
authors.lastname: Chiu
authors.forename: Philip Y
authors.initials: PY
authors.lastname: Lam
authors.forename: Chung Wai
authors.initials: CW
authors.lastname: Yan
authors.forename: Kam Ming
authors.initials: KM
authors.lastname: Ko
mesh_terms: D002478:Cells, Cultured; D034242:Cyclooctanes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011083:Polycyclic Compounds / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000517:prevention & control*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D032141:Schisandra / Q000737:chemistry; D013472:Sunlight / Q000009:adverse effects
chemical_list: D034242:Cyclooctanes; D017705:Lignans; D010936:Plant Extracts; D011083:Polycyclic Compounds; D017382:Reactive Oxygen Species; C015499:schizandrin B; D003577:Cytochrome P-450 Enzyme System; D010447:Peptide Hydrolases; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1; D005978:Glutathione