title: The sweet connection: Solving the riddle of multiple sugar-binding fimbrial adhesins in Escherichia coli: Multiple E. coli fimbriae form a versatile arsenal of sugar-binding lectins potentially involved in surface-colonisation and tissue tropism.
abstract: Proteinaceous stalks produced by Gram-negative bacteria are often used to adhere to environmental surfaces. Among them, chaperone-usher (CU) fimbriae adhesins, related to prototypical type 1 fimbriae, interact in highly specific ways with different ligands at different stages of bacterial infection or surface colonisation. Recent analyses revealed a large number of potential and often "cryptic" CU fimbriae homologues in the genome of commensal and pathogenic Escherichia coli and closely related bacteria. We propose that CU fimbriae form a yet unexplored arsenal of lectins, carbohydrate-binding proteins involved in various aspects of bacterial surface adhesion and tissue tropism. Combined efforts of molecular and structural biologists will be required to unravel the biological contribution of the bacterial lectome, however, current progress has already opened up new perspectives in the design of novel anti-infective strategies.
authors.affiliation: Institut Pasteur, Unité de Génétique des Biofilms, Département de Microbiologie, Paris, France.
authors.forename: Charalampia-Georgia
authors.initials: CG
authors.lastname: Korea
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Ghigo
authors.forename: Christophe
authors.initials: C
authors.lastname: Beloin
mesh_terms: D018830:Adhesins, Escherichia coli / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D002448:Cell Adhesion; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000517:prevention & control; D029968:Escherichia coli Proteins / Q000378:metabolism*; D010861:Fimbriae, Bacterial / Q000378:metabolism*; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D009876:Operon; D011485:Protein Binding; D015398:Signal Transduction; D013499:Surface Properties; D018523:Tropism
chemical_list: D018830:Adhesins, Escherichia coli; D029968:Escherichia coli Proteins; D037102:Lectins