title: Genetic control of hepatitis A severity and susceptibility to allergy.
abstract: Hepatitis A virus (HAV) usually results in asymptomatic infection or mild disease, but in a small subset of patients it can lead to severe disease and even liver failure. In this issue of the JCI, Kim et al. identify a polymorphism associated with this increased disease risk in the gene that encodes the HAV receptor--TIM1. Importantly, this TIM1 gene polymorphism protects from the development of atopic diseases in HAV-seropositive individuals.
authors.affiliation: Université Paris Descartes, INSERM, Paris, France.
authors.forename: Lucienne
authors.initials: L
authors.lastname: Chatenoud
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Bach
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006506:Hepatitis A / Q000150:complications* / Q000235:genetics* / Q000821:virology; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000235:genetics* / Q000821:virology; D007694:Killer Cells, Natural / Q000166:cytology; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D011110:Polymorphism, Genetic; D011991:Receptors, Virus / Q000235:genetics; D012306:Risk
chemical_list: C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus