title: A new self-expanding transcatheter aortic valve for transapical implantation - first in man implantation of the JenaValve™.
abstract: Transapical aortic valve implantation (TA-AVI) has evolved as a routine procedure to treat selected high-risk elderly patients. In the vast majority, the balloon-expandable SAPIEN™ prosthesis has been used for TA-AVI. The new JenaValve™ prosthesis is designed for antegrade transapical implantation and consists of a self-expandable Nitinol™ stent with a porcine tissue-prosthesis mounted on a sheath-less delivery catheter. Key features of the device are three 'positioning feelers' facilitating intuitive 'self-positioning' valve implantation. The JenaValve™ concept results in a subcoronary valve position with an anatomically correct valve rotation relying on axial in addition to radial fixation by the three Nitinol™ 'feelers' embracing the native valve leaflets. Here, we report the successful first-in-man implantation in an elderly high-risk patient using a transapical off-pump approach. The JenaValve™ demonstrated proof of concept and a good functional result immediately after deployment and at 12-months' follow-up.
authors.affiliation: Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany. Kempfert@web.de
authors.forename: Jörg
authors.initials: J
authors.lastname: Kempfert
authors.forename: Ardawan J
authors.initials: AJ
authors.lastname: Rastan
authors.forename: Friedrich-W
authors.initials: FW
authors.lastname: Mohr
authors.forename: Thomas
authors.initials: T
authors.lastname: Walther
mesh_terms: D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000601:surgery*; D001705:Bioprosthesis; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D019060:Minimally Invasive Surgical Procedures / Q000295:instrumentation / Q000379:methods; D011474:Prosthesis Design; D015607:Stents