title: Severe hypoglycemic seizures in a child receiving 6-mercaptopurine.
abstract: A 4-year-old boy with acute lymphoblastic leukemia who was receiving 6-mercaptopurine during the maintenance chemotherapy experienced prolonged generalized tonic nocturnal seizures because of severe hypoglycemia after his evening dose by a 12-hour period of fasting. Investigations ruled out all causes of these seizures other than the 6-mercaptopurine-induced severe hypoglycemia.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, Childrens' Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Mohamad K
authors.initials: MK
authors.lastname: El-Bitar
authors.forename: Samar A
authors.initials: SA
authors.lastname: Muwakkit
authors.forename: Omar
authors.initials: O
authors.lastname: Dabbagh
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D002675:Child, Preschool; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects*; D008727:Methotrexate / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012640:Seizures / Q000139:chemically induced*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage
chemical_list: D000890:Anti-Infective Agents; D000964:Antimetabolites, Antineoplastic; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D015122:Mercaptopurine; D008727:Methotrexate