title: Ca2+-signaling, alternative splicing and endoplasmic reticulum stress responses.
abstract: Ca(2+)-signaling, alternative splicing, and stress responses by the endoplasmic reticulum are three important cellular activities which can be strongly interconnected to alter the expression of protein isoforms in a tissue dependent manner or during development depending on the environmental conditions. This integrated network of signaling pathways permits a high degree of versatility and adaptation to metabolic, developmental and stress processes. Defects in its regulation may lead to cellular malfunction.
authors.affiliation: NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Goettingen, Germany. jkrebs@nmr.mpibpc.mpg.de
authors.forename: Joachim
authors.initials: J
authors.lastname: Krebs
authors.forename: Jody
authors.initials: J
authors.lastname: Groenendyk
authors.forename: Marek
authors.initials: M
authors.lastname: Michalak
mesh_terms: D051702:Activating Transcription Factor 6 / Q000378:metabolism; D017398:Alternative Splicing / Q000187:drug effects*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology*; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics / Q000502:physiology*; D020033:Protein Isoforms / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D013312:Stress, Physiological; D056811:Unfolded Protein Response / Q000502:physiology; D019892:eIF-2 Kinase / Q000378:metabolism
chemical_list: D051702:Activating Transcription Factor 6; D002118:Calcium; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins; D008565:Membrane Proteins; D053499:Plasma Membrane Calcium-Transporting ATPases; D020033:Protein Isoforms; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase; C497111:ATF6 protein, human; C486556:Ern2 protein, mouse