title: Presence of maternal anti-HBs antibodies does not influence hepatitis B vaccine response in Brazilian neonates.
abstract: Recently, it was suggested that maternal hepatitis B surface antigen antibodies (anti-HBs) acquired transplacentally could play a negative role in newborn infants' immune response to the hepatitis B vaccine. We compared the hepatitis B virus (HBV) vaccine response in infants born to mothers previously vaccinated against HBV (n = 91) to infants born to mothers who were not previously vaccinated (n = 221). All newborn infants received three intramuscular doses (10 μg) of HBV vaccine (Butang®) at 0,1 and six months. The first dose was administered at the maternity hospital within 12 h of birth. The geometric mean titres of anti-HBs were not different among newborn infants born to mothers who were anti-HBs-negative (492.7 mIU/mL) and anti-HBs-positive (578.7 mIU/mL) (p = 0.38). Eight infants did not respond to the HBV vaccine. Of them, six were born to anti-HBs-negative mothers and two were born to mothers with anti-HBs titres less than 50 mlU/mL. Despite the mother's anti-HBs-positive status, our data show a good immunogenicity of the Brazilian HBV recombinant vaccine in neonates.
authors.affiliation: Faculdade de Enfermagem, Universidade Federal de Goiás, Rua 227 quadra 68, 74605-080 Goiânia, GO, Brasil.
authors.forename: Ana Luiza N
authors.initials: AL
authors.lastname: Junqueira
authors.forename: Viviane R
authors.initials: VR
authors.lastname: Tavares
authors.forename: Regina M B
authors.initials: RM
authors.lastname: Martins
authors.forename: Kamilla V
authors.initials: KV
authors.lastname: Frauzino
authors.forename: Agabo M da Costa e
authors.initials: AM
authors.lastname: Silva
authors.forename: Izolina M X
authors.initials: IM
authors.lastname: Rodrigues
authors.forename: Ruth
authors.initials: R
authors.lastname: Minamisava
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Teles
mesh_terms: D000328:Adult; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000097:blood* / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines