title: Extrinsic and intrinsic control of germ cell proliferation in Caenorhabditis elegans.
abstract: The germ cells of Caenorhabditis elegans serve as a useful model to study the balance between proliferation and differentiation within the context of development and changing environmental signals experienced by the animal. Germ cells adjacent to a stem cell niche in the distal region of the gonad retain the capacity to divide during adulthood, making them unique from other cells in the organism. We will highlight recent advances in our understanding of mechanisms that control proliferation, as well as the signaling pathways involved in promoting mitosis at the expense of differentiation.
authors.affiliation: Department of Genetics, Yale University, New Haven, CT 06520, USA.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Waters
authors.forename: Valerie
authors.initials: V
authors.lastname: Reinke
mesh_terms: D000824:Animal Nutritional Physiological Phenomena / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D004249:DNA Damage / Q000502:physiology; D005854:Germ Cells / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D051880:Receptors, Notch / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D051880:Receptors, Notch