title: Behavioral impairment and oxidative damage induced by chronic application of nonylphenol.
abstract: Nonylphenol (NP) is a degradation product of nonylphenol polyethoxylates, which are widely used in the production of industrial and consumer surfactants. The aim of the present study was to evaluate the effect of NP on the antioxidant capacity and cognitive ability of mice. NP was given orally by gavages at doses of 0, 50, 100, and 200 mg kg(-1) d(-1) for 90 days. The results showed that NP significantly decreased the activity of superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) and at the same time increased malondialdehyde (MDA) levels in mice brains. Exploration, memory function and ability to learn a novel task were significantly decreased in NP fed mice. These results indicate that chronic high dose of NP exposure has the potential to generate oxidative stress and induce the cognitive impairment in male mice.
authors.affiliation: School of Environment Science and Spatial Informatics, China University of Mining and Technology, Xuzhou 221008, Jiangsu, China; E-Mail: yqzhang@cumt.edu.cn (Y.-Q.Z.).
authors.forename: Zhen
authors.initials: Z
authors.lastname: Mao
authors.forename: Yuan-Lin
authors.initials: YL
authors.lastname: Zheng
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004785:Environmental Pollutants / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008815:Mice, Inbred Strains; D018384:Oxidative Stress; D010636:Phenols / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D004785:Environmental Pollutants; D010636:Phenols; C025256:nonylphenol