title: Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for severe aplastic anemia.
abstract: Matched sibling donor hematopoietic stem cell transplantation is the standard of care for severe aplastic anemia, with an overall survival of 80% to 90%. Only 60% to 70% of patients respond to treatment with immunosuppressive therapy. The main life threatening complications are infections, graft failure, and graft versus host disease. A 10-year-old patient with severe aplastic anemia underwent matched sibling donor hematopoietic stem cell transplantation, but developed sudden onset of fatal multiorgan failure on day +12. The cause of death was found only after autopsy.
authors.affiliation: Department of Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Rawlinson
authors.forename: Bonita
authors.initials: B
authors.lastname: Fung
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Gross
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Termuhlen
authors.forename: Micah
authors.initials: M
authors.lastname: Skeens
authors.forename: Amy
authors.initials: A
authors.lastname: Garee
authors.forename: Sandeep
authors.initials: S
authors.lastname: Soni
authors.forename: Daniel
authors.initials: D
authors.lastname: Pietryga
authors.forename: Rajinder P S
authors.initials: RP
authors.lastname: Bajwa
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000601:surgery*; D002648:Child; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D009091:Mucormycosis / Q000150:complications* / Q000188:drug therapy; D009102:Multiple Organ Failure / Q000209:etiology*; D011743:Pyrimidines / Q000627:therapeutic use; D020103:Rhizomucor; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D011743:Pyrimidines; D014230:Triazoles; C068538:liposomal amphotericin B; D000666:Amphotericin B; D065819:Voriconazole