title: Reactive oxygen species in photochemistry of the red fluorescent protein "Killer Red".
abstract: The fluorescent protein aptly named "Killer Red" (KRed) is capable of killing transfected cells and inactivating fused proteins upon exposure to visible light in the presence of oxygen. We have investigated the source of the bioactive species through a variety of photophysical and photochemical techniques. Our results indicate a Type I (electron transfer mediated) photosensitizing mechanism.
authors.affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA.
authors.forename: Russell B
authors.initials: RB
authors.lastname: Vegh
authors.forename: Kyril M
authors.initials: KM
authors.lastname: Solntsev
authors.forename: Marina K
authors.initials: MK
authors.lastname: Kuimova
authors.forename: Soohee
authors.initials: S
authors.lastname: Cho
authors.forename: Yue
authors.initials: Y
authors.lastname: Liang
authors.forename: Bernard L W
authors.initials: BL
authors.lastname: Loo
authors.forename: Laren M
authors.initials: LM
authors.lastname: Tolbert
authors.forename: Andreas S
authors.initials: AS
authors.lastname: Bommarius
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D004579:Electron Transport; D049452:Green Fluorescent Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008027:Light; D008164:Luminescent Proteins / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D010777:Photochemistry / Q000379:methods*; D010778:Photochemotherapy / Q000379:methods; D017382:Reactive Oxygen Species / Q000378:metabolism; D000097573:Red Fluorescent Protein
chemical_list: D000975:Antioxidants; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins; D017382:Reactive Oxygen Species; D000097573:Red Fluorescent Protein; C508771:killer red protein, Anthomedusae