title: Malaysianol A, a new trimer resveratrol oligomer from the stem bark of Dryobalanops aromatica.
abstract: A new resveratrol trimer, malaysianol A (1), five known resveratrol oligomers: laevifonol (2), ampelopsin E (3), α-viniferin (4), ε-viniferin (5), diptoindonesin A (6), and bergenin (7) have been isolated from the acetone extract of the stem bark of Dryobalanops aromatica by combination of vacuum and radial chromatography techniques. Their structures were established on the basis of their spectroscopic evidence and comparison with the published data. The cytotoxic activity of the compounds was tested against several cell lines in which compound 4 was found to inhibit strongly the growth of HL-60 cell line.
authors.affiliation: Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor Darul Ehsan, Malaysia.
authors.forename: A
authors.initials: A
authors.lastname: Wibowo
authors.forename: N
authors.initials: N
authors.lastname: Ahmat
authors.forename: A S
authors.initials: AS
authors.lastname: Hamzah
authors.forename: A S
authors.initials: AS
authors.lastname: Sufian
authors.forename: N H
authors.initials: NH
authors.lastname: Ismail
authors.forename: R
authors.initials: R
authors.lastname: Ahmad
authors.forename: F M
authors.initials: FM
authors.lastname: Jaafar
authors.forename: H
authors.initials: H
authors.lastname: Takayama
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D053958:Dipterocarpaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D013267:Stilbenes; C560485:malaysianol A; D000077185:Resveratrol