title: Dynamic reciprocity in the wound microenvironment.
abstract: Here, we define dynamic reciprocity (DR) as an ongoing, bidirectional interaction among cells and their surrounding microenvironment. In this review, we posit that DR is especially meaningful during wound healing as the DR-driven biochemical, biophysical, and cellular responses to injury play pivotal roles in regulating tissue regenerative responses. Such cell-extracellular matrix interactions not only guide and regulate cellular morphology, but also cellular differentiation, migration, proliferation, and survival during tissue development, including, e.g., embryogenesis, angiogenesis, as well as during pathologic processes including cancer, diabetes, hypertension, and chronic wound healing. Herein, we examine DR within the wound microenvironment while considering specific examples across acute and chronic wound healing. This review also considers how a number of hypotheses that attempt to explain chronic wound pathophysiology may be understood within the DR framework. The implications of applying the principles of DR to optimize wound care practice and future development of innovative wound healing therapeutics are also briefly considered.
authors.affiliation: Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, USA.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Schultz
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Davidson
authors.forename: Robert S
authors.initials: RS
authors.lastname: Kirsner
authors.forename: Paul
authors.initials: P
authors.lastname: Bornstein
authors.forename: Ira M
authors.initials: IM
authors.lastname: Herman
mesh_terms: D000818:Animals; D018441:Biofilms; D002450:Cell Communication; D002465:Cell Movement; D049109:Cell Proliferation; D002908:Chronic Disease; D017719:Diabetic Foot / Q000503:physiopathology; D005109:Extracellular Matrix / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D016023:Integrins / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D020782:Matrix Metalloproteinases / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D014647:Varicose Ulcer / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000378:metabolism
chemical_list: D016023:Integrins; D036341:Intercellular Signaling Peptides and Proteins; D020782:Matrix Metalloproteinases