title: [Development of cell-penetrating peptides as vectors for drug delivery].
abstract: Biomacromolecules play an important role in the treatment of many diseases, but as a result of cell membrane serving as the natural barriers, only the small molecular compounds whose molecular weights are smaller than 600 Da can get through cell membrane and enter the cell. In recent years, some short peptides (the length less than 30 amino acids) are found to have the cell-penetrating function, called cell-penetrating peptides (CPPs). They are able to effectively translocate segments of protein, polypeptides, nucleic acid into the cells of many mammal animals with many methods. They have high transduction efficiency and will not lead to cell damage. So, the discovery of CPPs has a very good applicable prospect in such research fields as cell-biology, gene-therapy, drug transduction in vivo, evaluation of clinical medicine and medical immunology. This paper reviews the types and characteristics of CPPs, internalization mechanisms, applications, and their existing problems.
authors.affiliation: Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Ren
authors.forename: Chuan-Guang
authors.initials: CG
authors.lastname: Qin
authors.forename: Chun-Lan
authors.initials: CL
authors.lastname: Xu
authors.forename: Qiu-Yu
authors.initials: QY
authors.lastname: Wang
authors.forename: Xiao-Jia
authors.initials: XJ
authors.lastname: Zuo
mesh_terms: D000042:Absorption / Q000187:drug effects; D000595:Amino Acid Sequence; D000818:Animals; D002463:Cell Membrane Permeability; D057846:Cell-Penetrating Peptides / Q000145:classification / Q000494:pharmacology* / Q000502:physiology; D004337:Drug Carriers; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D021381:Protein Transport
chemical_list: D057846:Cell-Penetrating Peptides; D004337:Drug Carriers