title: A "click and activate" approach in one-pot synthesis of a triazolyl-pyridazinone library.
abstract: A "click and activate" strategy was designed and executed in a four-component, stepwise condensation that led to a trisubstituted triazolyl-pyridazinone library. This one-pot process included regioselective azide substitution at 2-substituted-4,5-dichloropyridazinones, followed by a Cu(I) catalyzed triazole formation which triggered subsequent nucleophilic substitution at the neighboring position to achieve three points of diversity.
authors.affiliation: Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States. wqian@amgen.com
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Qian
authors.forename: David
authors.initials: D
authors.lastname: Winternheimer
authors.forename: Jennifer
authors.initials: J
authors.lastname: Allen
mesh_terms: D000588:Amines / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000588:Amines; D011724:Pyridazines; D014230:Triazoles