title: Liver transplantation in a patient treated by sorafenib for hepatocellular carcinoma.
abstract: Sorafenib is a multikinase inhibitor currently used in the palliative treatment of advanced hepatocellular carcinoma. In patients with small hepatocellular carcinoma, sorafenib could be suggested as neoadjuvant therapy to control tumor growth during waiting time for liver transplantation. However, up to now, safety of liver transplantation in patients undergoing sorafenib treatment is not known. Herein, we report a case of successful liver transplantation in a patient treated by sorafenib for hepatocellular carcinoma. In this patient, liver transplantation was performed safely and histological examination of explanted liver evidenced complete necrosis of the largest tumor nodule.
authors.affiliation: Service d'hépato-gastroentérologie, CHU Conception, 147 boulevard Baille, Marseille cedex 05, France.
authors.forename: P
authors.initials: P
authors.lastname: Borentain
authors.forename: E
authors.initials: E
authors.lastname: Gregoire
authors.forename: J
authors.initials: J
authors.lastname: Hardwigsen
authors.forename: S
authors.initials: S
authors.lastname: Garcia
authors.forename: O
authors.initials: O
authors.lastname: Durieux
authors.forename: Y-P
authors.initials: YP
authors.lastname: Le Treut
authors.forename: R
authors.initials: R
authors.lastname: Gérolami
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001557:Benzenesulfonates / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D016031:Liver Transplantation; D008875:Middle Aged; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D011725:Pyridines / Q000627:therapeutic use*; D000077157:Sorafenib
chemical_list: D000970:Antineoplastic Agents; D001557:Benzenesulfonates; D010671:Phenylurea Compounds; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib