title: Increased expression of Foxj1 after traumatic brain injury.
abstract: Foxj1 is a member of the Forkhead/winged-helix (Fox) family of transcription factors, which is required for postnatal differentiation of ependymal cells and a subset of astrocytes in the subventricular zone. The subpopulation of astrocytes has the ability of self-renew and neurogenic potential differentiated into astrocytes, oligodendrocytes, and neurons. However, its expression and function in the central nervous system lesion are not well understood. In this study, we performed a traumatic brain injury (TBI) model in adult rats and investigated the changed expression of Foxj1 in the brain cortex. Western blot and immunohistochemistry analysis showed that the expression of Foxj1 gradually increased, reached a peak at day 3 after TBI, and declined during the following days. Double immunofluorescence staining revealed that Foxj1 was co-expressed with MAP-2 and GFAP. In addition, we detected that Ki67 had the co-localization with NeuN, GFAP, and Foxj1. All our findings suggested that Foxj1 may be involved in the pathophysiology of brain after TBI.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, People's Republic of China. cuigang33@yahoo.com.cn
authors.forename: Gang
authors.initials: G
authors.lastname: Cui
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Yu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Lu
authors.forename: Chunhui
authors.initials: C
authors.lastname: Qian
authors.forename: Jiliang
authors.initials: J
authors.lastname: Li
authors.forename: Yunlin
authors.initials: Y
authors.lastname: Ding
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism* / Q000473:pathology*; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D049109:Cell Proliferation; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015415:Biomarkers; C500666:FOXJ1 protein, rat; D051858:Forkhead Transcription Factors