title: [Percutaneous aortic valvuloplasty in congenital aortic valve stenosis performed in patients older than one month: a good alternative to surgery].
abstract: BACKGROUND
  Percutaneous aortic valvuloplasty is an effective means of treatment for congenital aortic valve stenosis. The aim of this study was to evaluate the immediate results of valvuloplasty, to analyze the medium to long-term outcome and to assess its efficacy in preventing or postponing a new percutaneous valvuloplasty or aortic valve surgery.
  
  
  METHODS
  We retrospectively analyzed the reports of 37 patients aged > 1 month (mean age 6.3 years) who underwent aortic valvuloplasty for severe aortic stenosis. Associated congenital cardiac defects were present in 16% of the patients. The average time of follow-up was 5.07 years. Particular attention was focused on occurrence and progression of aortic regurgitation.
  
  
  RESULTS
  Hemodynamic gradient after aortic valvuloplasty decreased from 58.5 to 22.5 mmHg, with an average decrease of 61.5%. On echography, the maximum gradient decreased from 93.0 to 40.5 mmHg, with an average decrease of 56.5%; mean gradient decreased from 52.0 to 20.5 mmHg with an average decrease of 60.6%. At last follow-up the average maximum and mean gradient on echo were 50.0 and 27.0 mmHg. A reintervention was needed in 21.6% of cases: a second valvuloplasty in 8.1% and aortic surgery in 13.5%. The mortality rate was 2.7%. Survival after 14 years was 97.2%; freedom from aortic valve surgery was 85.5%, from a second valvuloplasty was 89.5%, and from any type of procedure was 76.1%.
  
  
  CONCLUSIONS
  Percutaneous aortic valvuloplasty is a safe and effective treatment for congenital aortic stenosis in patients aged > 1 month. Aortic regurgitation is the main concern in the follow-up. Nonetheless, 14 years after valvuloplasty, over 75% of patients are free from any type of aortic valve reintervention.
authors.affiliation: Istituto di Cardiologia e Cardiochirurgia Pediatrica, Policlinico S. Orsola-Malpighi, Bologna. coscia83@hotmail.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Corzani
authors.forename: Andrea
authors.initials: A
authors.lastname: Donti
authors.forename: Valentina
authors.initials: V
authors.lastname: Gesuete
authors.forename: Roberto
authors.initials: R
authors.lastname: Formigari
authors.forename: Gabriella
authors.initials: G
authors.lastname: Testa
authors.forename: Gabriele
authors.initials: G
authors.lastname: Bronzetti
authors.forename: Anna
authors.initials: A
authors.lastname: Balducci
authors.forename: Marianna
authors.initials: M
authors.lastname: Fabi
authors.forename: Marco
authors.initials: M
authors.lastname: Bonvicini
authors.forename: Fernando Maria
authors.initials: FM
authors.lastname: Picchio
mesh_terms: D000293:Adolescent; D000328:Adult; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D001024:Aortic Valve Stenosis / Q000151:congenital / Q000503:physiopathology / Q000628:therapy*; D002404:Catheterization / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D019233:Retreatment; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult