title: [Chronic obstructive pulmonary disease and asthma].
abstract: Chronic obstructive pulmonary disease and asthma are both highly prevalent inflammatory diseases characterized by airway obstruction with distinct pathogenic mechanisms and different degrees of response to antiinflammatory therapy. However, forms of presentation that show overlap between both diseases and which are not clearly represented in clinical trials are frequently encountered in clinical practice. These patients may show accelerated loss of pulmonary function and have a worse prognosis. Therefore their early identification is essential. Biomarkers such as bronchial hyperreactivity or nitric oxide in exhaled air have yielded discrepant results. Phenotypic characterization will allow treatment with inhaled corticosteroids to be individually tailored and optimized.
authors.affiliation: Ciber de Enfermedades Respiratorias, Hospital Universitario Son Dureta, Palma de Mallorca, Spain. borja.cosio@ssib.es
authors.forename: Borja G
authors.initials: BG
authors.lastname: Cosío
authors.forename: Federico
authors.initials: F
authors.lastname: Fiorentino
authors.forename: Sergio
authors.initials: S
authors.lastname: Scrimini
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000402:Airway Obstruction / Q000209:etiology; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D016535:Bronchial Hyperreactivity / Q000453:epidemiology / Q000503:physiopathology; D001991:Bronchitis / Q000150:complications; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D015897:Comorbidity; D003937:Diagnosis, Differential; D006801:Humans; D007249:Inflammation; D008954:Models, Biological; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D011656:Pulmonary Emphysema / Q000150:complications; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013224:Status Asthmaticus / Q000175:diagnosis / Q000503:physiopathology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D001993:Bronchodilator Agents