title: Role of individual and developmental differences in voluntary cocaine intake in rats.
abstract: BACKGROUND
  Early-onset drug taking is associated with increased likelihood of addiction, but it is unclear whether early onset is causal in development of addiction. Many other factors are associated with increased risk of addiction and also promote early intake. Here, a rodent model is used to explore the causality of early onset in development of self-administration and addiction-like behavior and to examine factors that promote self-administration.
  
  
  METHODS
  We used cocaine self-administration to examine drug taking and addiction-like behavior in adolescent and adult rats a priori characterized for their locomotor responses to novelty and cocaine and behavior in the light-dark task.
  
  
  RESULTS
  Adolescent animals initially sought more cocaine than adults. However, as the adolescents matured, their intake fell and they did not differ from adults in terms of unreinforced lever-pressing, extinction or reinstatement behavior. For both age groups, self-administration was positively correlated with the locomotor response to novelty, the locomotor response to cocaine, and with time in light in the light-dark task. The rats that were insensitive to cocaine's locomotor effects and that spent the least time in light in the light-dark task sought the least cocaine, appearing to be "protected" from the reinforcing effects of cocaine. There was no difference between the two age groups in appearance of this "protected" phenotype.
  
  
  CONCLUSIONS
  These results suggest that early onset of drug taking may promote increased use, but does not promote progression to addiction-like behavior. Furthermore, protective factors, such as innate anxiety and insensitivity to cocaine's pharmacological effects, function across developmental stages.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. Nicole.schrammsapyta@duke.edu
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Schramm-Sapyta
authors.forename: Marty C
authors.initials: MC
authors.lastname: Cauley
authors.forename: Dalene K
authors.initials: DK
authors.lastname: Stangl
authors.forename: Susan
authors.initials: S
authors.lastname: Glowacz
authors.forename: K Amy
authors.initials: KA
authors.lastname: Stepp
authors.forename: Edward D
authors.initials: ED
authors.lastname: Levin
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Kuhn
mesh_terms: D000367:Age Factors; D000818:Animals; D016739:Behavior, Addictive / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000008:administration & dosage*; D019970:Cocaine-Related Disorders / Q000503:physiopathology*; D003624:Darkness; D008027:Light; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012646:Self Administration; D013997:Time Factors
chemical_list: D003042:Cocaine