title: A fatal case of hemoperitoneum after ultrasound-guided liver biopsy in a patient with intravascular large B-cell lymphoma.
abstract: An autopsy case of fatal complication of percutaneous liver biopsy targeting a rare type of large B-cell lymphoma is presented. A 79 year-old man was referred to the hematology unit of a hospital because of anemia with thrombocytopenia and hepatosplenomegaly. Results of inguinal lymph node biopsy were inconclusive. To investigate a mass lesion in the liver visualized by ultrasonography, image-guided liver biopsy was performed following platelet infusion. The patient became unresponsive 6h post procedure because of hypotension due to intraperitoneal hemorrhage of undetermined origin. Autopsy revealed hemoperitoneum but failed to identify any macroscopic intra- or extrahepatic vascular injuries. Histopathological investigation disclosed infiltration of atypical lymphocytes into the systemic organs including the lymph nodes, spleen, liver, and lungs. Prominent hemophagocytosis was also noted. The lymphoma cells were exclusively accumulated within vascular and sinusoidal structures, and diagnosed with immunohistochemistry as Asian variant of intravascular large B-cell lymphoma. Massive blood extravasation was presumed to originate directly from the markedly dilated liver sinusoids filled with erythrocytes, macrophages and tumor cells, under the condition of impaired hemostasis. Although the biopsy was thought to have been correctly performed, this case would be instructive for evaluation of the indications and risks associated with liver biopsy.
authors.affiliation: Department of Forensic Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. aokiy@med.nagoya-cu.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Aoki
authors.forename: Masataka
authors.initials: M
authors.lastname: Takamiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Satoh
authors.forename: Sachiko
authors.initials: S
authors.lastname: Fujita
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kato
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Maeno
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle / Q000009:adverse effects*; D017809:Fatal Outcome; D049429:Forensic Pathology; D006465:Hemoperitoneum / Q000209:etiology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008297:Male; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D010587:Phagocytosis; D018084:Ultrasonography, Interventional