title: [Clinical efficacy of reamberine in therapy for influenza].
abstract: OBJECTIVE
  To evaluate the tolerance and therapeutic effectiveness of 1.5% reamberine (RB) solution infusions in complex therapy for pneumonia-complicated pneumonia and acute respiratory diseases (ARD).
  
  
  METHODS
  133 patients aged 18 to 60 years with pneumonia-complicated influenza and ARD were examined. The investigators measured the dynamic serum levels of metalloproteins (MP), such as transferrin, lactoferrin, and ceruloplasmin, and the activity of superoxide dismutase. They also studied the concentration of secondary lipid peroxidation products (malondialdehyde) by the so-called thiobarbituric acid test.
  
  
  RESULTS
  Dropwise intravenous RB infusions exerted a modifying effect on MP content, contributed to more pronounced stabilization of a serum antioxidant potential (versus olifen, vitamin E, and basic therapy) and to enhanced nonspecific protection, which was accompanied by a significant clinical improvement.
  
  
  CONCLUSIONS
  The study revealed the high clinical efficacy of 1.5% RB solution infusions (300 ml for 4-5 days) in the treatment of 74 patients with pneumonia-complicated influenza, stabilized serum antioxidant potential, and the body's enhanced nonspecific resistance.
authors.forename: V A
authors.initials: VA
authors.lastname: Isakov
authors.forename: L P
authors.initials: LP
authors.lastname: Vodeĭko
authors.forename: I V
authors.initials: IV
authors.lastname: Kabolova
authors.forename: V V
authors.initials: VV
authors.lastname: Turkin
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D007262:Infusions, Intravenous; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008667:Metalloproteins / Q000097:blood; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D008667:Metalloproteins; C549374:Reamberin; D013386:Succinates; D008315:Malondialdehyde; D008536:Meglumine; D013482:Superoxide Dismutase