title: [Comparison of in vivo characteristics of polyethylene wear particles produced by a metal and a ceramic femoral component in total knee replacement].
abstract: OBJECTIVE
  The aim of the study was to evaluate in vivo and compare, in terms of the quality and number of ultra high-molecular polyethylene (UHMWPE) wear particles, total knee replacements of identical construction differing only in the material used for femoral component production, i.e., CoCrMo alloy or ZrO2 ceramics.
  
  
  METHODS
  Samples of peri-prosthetic granuloma tissue were collected in two patients with total knee replacement suffering from implant migration, who were matched in relevant characteristics. The primary knee replacement in Patient 1 with a CoCrMo femoral component was done 7.2 years and in Patient 2 with a ZrO2 implant 6.8 years before this assessment. The polyethylene wear-induced granuloma was analysed by the MORF method enabling us to assess the shape and size of wear debris and the IRc method for assessment of particle concentration.
  
  
  RESULTS
  In the granuloma tissue samples of Patient 1, on the average, particles were 0.30 mm in size and their relative volume was 0.19. In the Patient 2 tissue samples, the average size of particles was 0.33 mm and their relative volume was 0.26. There was no significant difference in either particle morphology or their concentration in the granuloma tissue between the two patients.
  
  
  CONCLUSIONS
  One of the options of how to reduce the production of polyethylene wear particles is to improve the tribological properties of contacting surfaces in total knee replacement by substituting a cobalt-chrome femoral component with a zirconia ceramic femoral component. The previous in vitro testing carried out with a mechanical simulator under conditions approaching real weight-bearing in the human body did show a nearly three-fold decrease in the number of UHMWPE wear particles in zirconia components. The evaluation of granuloma tissue induced by the activity of a real prosthetic joint for nearly seven years, however, did not reveal any great difference in either quality or quantity of polyethylene debris between the two replacements. The difference of surface roughness between CoCrMo (Ra = 0.05) and ZrO2 (Ra = 0.02) components did not play any role in in vivo conditions. CONCLUSIONS In accordance with a previous clinical study, this evaluation of the quality and quantity of UHMWPE wear particles produced by a ceramic femoral component in vivo failed to demonstrate any advantage of zirconia ceramic components over the cobalt-chrome femoral components so far used.
authors.affiliation: I. ortopedická klinika 1. LF UK a FN Motol, Prague.
authors.forename: D
authors.initials: D
authors.lastname: Veigl
authors.forename: P
authors.initials: P
authors.lastname: Vavřík
authors.forename: D
authors.initials: D
authors.lastname: Pokorný
authors.forename: M
authors.initials: M
authors.lastname: Slouf
authors.forename: E
authors.initials: E
authors.lastname: Pavlova
authors.forename: I
authors.initials: I
authors.lastname: Landor
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D002516:Ceramics; D002858:Chromium Alloys; D019544:Equipment Failure Analysis; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology; D006801:Humans; D007720:Knee Prosthesis; D008875:Middle Aged; D010316:Particle Size; D011095:Polyethylenes; D011475:Prosthesis Failure; D015040:Zirconium
chemical_list: D002858:Chromium Alloys; D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene; D015040:Zirconium; C028541:zirconium oxide