title: Modeling cancers in Drosophila.
abstract: The basic cellular processes deregulated during carcinogenesis and the vast majority of the genes implicated in cancer appear conserved from humans to flies. This conservation, together with an ever-expanding fly genetic toolbox, has made of Drosophila melanogaster a remarkably profitable model to study many fundamental aspects of carcinogenesis. In particular, Drosophila has played a major role in the identification of genes and pathways implicated in cancer and in disclosing novel functional relationships between cancer genes. It has also proved to be a genetically tractable system where to mimic cancer-like situations and characterize the mode of action of human oncogenes. Here, we outline some advances in the study of cancer, both at the basic and more translational levels, which have benefited from research carried out in flies.
authors.affiliation: Université de Toulouse, UPS, CBD, Centre de Biologie du Développement, Bâtiment 4R3, 118 route de Narbonne, F-31062, CNRS, F-31062 Toulouse, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Polesello
authors.forename: Fernando
authors.initials: F
authors.lastname: Roch
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gobert
authors.forename: Marc
authors.initials: M
authors.lastname: Haenlin
authors.forename: Lucas
authors.initials: L
authors.lastname: Waltzer
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D016764:Cell Polarity; D049109:Cell Proliferation; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology*