title: Standardised second-line treatment of multidrug-resistant tuberculosis during pregnancy.
abstract: We describe the efficacy and outcome of standardised second-line anti-tuberculosis (TB) medications during pregnancy. Treatment outcomes of five pregnant women with documented multidrug-resistant TB (MDR-TB) referred to the National Research Institute of Tuberculosis and Lung Diseases from 2003 to 2009 were analysed in two categories, maternal and neonatal. Patients became pregnant during treatment for MDR-TB without any changes in their anti-tuberculosis regimen. None of them had any adverse effects during pregnancy and delivery. No adverse effects were observed in mothers or neonates. The treatment of MDR-TB during pregnancy with a standardised second-line regimen in this study population was safe, with an acceptable rate of treatment success.
authors.affiliation: Mycobacteriology Research Centre, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: P
authors.initials: P
authors.lastname: Tabarsi
authors.forename: A
authors.initials: A
authors.lastname: Moradi
authors.forename: P
authors.initials: P
authors.lastname: Baghaei
authors.forename: M
authors.initials: M
authors.lastname: Marjani
authors.forename: M
authors.initials: M
authors.lastname: Shamaei
authors.forename: N
authors.initials: N
authors.lastname: Mansouri
authors.forename: E
authors.initials: E
authors.lastname: Chitsaz
authors.forename: P
authors.initials: P
authors.lastname: Farnia
authors.forename: D
authors.initials: D
authors.lastname: Mansouri
authors.forename: M
authors.initials: M
authors.lastname: Masjedi
authors.forename: A
authors.initials: A
authors.lastname: Velayati
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000382:microbiology; D011256:Pregnancy Outcome; D016896:Treatment Outcome; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents