title: Synthesis of peptidomimics through sugar-based scaffolds.
abstract: Poor oral bioavailability, low metabolic stability towards proteolysis and rapid excretion via both liver and kidneys displayed by innumerable peptides of potential therapeutic value has generated an intensive search for peptidomimics (1-2). A possible approach of such nonpeptidal peptidomimics is to replace the peptide by a scaffold that distributes in the space the peptidal side chains of amino acids essential for biological activity and mimics the bioactive conformation of the peptide.
authors.affiliation: Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, Universite Rene Descartes, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Le Merrer
authors.forename: L
authors.initials: L
authors.lastname: Poitout
authors.forename: J C
authors.initials: JC
authors.lastname: Depezay