title: Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients.
abstract: Over-expression of P-glycoprotein, encoded by the ABCB1 gene, is proposed to be involved in resistance to antiepileptic drugs in about 30% of patients with epilepsy. Here, we investigated the possible association between ABCB1 polymorphisms and sodium valproate (VPA) treatment in Malaysian epilepsy patients. Genotypes were assessed in 249 drug-resistant and 256 drug-responsive Malaysian patients for C1236T, G2677T/A, and C 5T polymorphisms in the ABCB1 gene. No genotypes, alleles, or haplotypes were associated with the response to VPA in either the overall group or Chinese, Indian, and Malay subgroups. Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene do not contribute to the response to VPA in patients with epilepsy.
authors.affiliation: Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. batoolsadat@yahoo.com
authors.forename: Batoul Sadat
authors.initials: BS
authors.lastname: Haerian
authors.forename: Kheng Seang
authors.initials: KS
authors.lastname: Lim
authors.forename: Hui Jan
authors.initials: HJ
authors.lastname: Tan
authors.forename: Elsa Hanifa Mejia
authors.initials: EH
authors.lastname: Mohamed
authors.forename: Chong Tin
authors.initials: CT
authors.lastname: Tan
authors.forename: Azman Ali
authors.initials: AA
authors.lastname: Raymond
authors.forename: Chee Piau
authors.initials: CP
authors.lastname: Wong
authors.forename: Sau Wei
authors.initials: SW
authors.lastname: Wong
authors.forename: Haslyna
authors.initials: H
authors.lastname: Omar
authors.forename: Harun
authors.initials: H
authors.lastname: Roslan
authors.forename: Zahurin
authors.initials: Z
authors.lastname: Mohamed
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000328:Adult; D000483:Alleles; D000927:Anticonvulsants / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy* / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008296:Malaysia; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000927:Anticonvulsants; D014635:Valproic Acid