title: Admixture aberration analysis: application to mapping in admixed population using pooled DNA.
abstract: Abstract Admixture mapping is a gene mapping approach used for the identification of genomic regions harboring disease susceptibility genes in the case of recently admixed populations such as African Americans. We present a novel method for admixture mapping, called admixture aberration analysis (AAA) that uses a DNA pool of affected admixed individuals. We demonstrate through simulations that AAA is a powerful and economical mapping method under a range of scenarios, capturing complex human diseases such as hypertension and end-stage kidney disease. The method has a low false-positive rate and is robust to deviation from model assumptions. Finally, we apply AAA on 600 prostate cancer-affected African Americans, replicating a known risk locus. Simulation results indicate that the method can yield over 96% reduction in genotyping. Our method is implemented as a Java program called AAAmap and is freely available at http://bioinfo.cs.technion.ac.il/AAAmap.
authors.affiliation: Computer Science Department, Technion-Israel Institute of Technology, Haifa, Israel. sberco@cs.technion.ac.il
authors.forename: Sivan
authors.initials: S
authors.lastname: Bercovici
authors.forename: Dan
authors.initials: D
authors.lastname: Geiger
mesh_terms: D001741:Black or African American / Q000235:genetics; D002874:Chromosome Mapping / Q000191:economics / Q000379:methods*; D003198:Computer Simulation; D004247:DNA / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics; D007676:Kidney Failure, Chronic / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008957:Models, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*
chemical_list: D004247:DNA