title: [Association between expression of lectin type receptors by natural killers and intensity of liver fibrosis during chronic hepatitis C].
abstract: OBJECTIVE
  To study functional activity of natural killers on different stages of fibrosis during chronic hepatitis C.
  
  
  METHODS
  Functional activity of CD3-/CD56+/CD16+ lymphocytes measured as expression of natural killers receptors (NKR) and natural cytotoxicity receptors (NCR) was assessed by flow cytometry.
  
  
  RESULTS
  At stage I of fibrosis, decrease of number of CD3-/CD56+/NKG2D+ cells was observed, whereas at precirrhotic stage III--sharp decrease of CD3-/CD56+/CD94+ and CD3-/ CD56+/NKG2D+ populations, and at cirrhotic stage--decrease of number of CD3-/CD56+/ NKG2D+ cells and increase of cytolytic activity of natural killers carrying CD107a marker compared to precirrhotic stage.
  
  
  CONCLUSIONS
  Obtained data demonstrate that natural killers during chronic hepatitis C receive regulatory signals mainly through lectin type receptors (CD94 and NKG2D).
authors.forename: E S
authors.initials: ES
authors.lastname: Malova
authors.forename: I P
authors.initials: IP
authors.lastname: Balmasova
authors.forename: N D
authors.initials: ND
authors.lastname: Iuschuk
authors.forename: E V
authors.initials: EV
authors.lastname: Shmeleva
authors.forename: O F
authors.initials: OF
authors.lastname: Eremina
mesh_terms: D000328:Adult; D003602:Cytotoxicity, Immunologic; D018450:Disease Progression; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008103:Liver Cirrhosis / Q000276:immunology* / Q000821:virology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D051920:NK Cell Lectin-Like Receptor Subfamily D / Q000378:metabolism; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000378:metabolism; D011975:Receptors, Mitogen / Q000276:immunology*
chemical_list: C497869:KLRD1 protein, human; C527085:KLRK1 protein, human; D051920:NK Cell Lectin-Like Receptor Subfamily D; D055655:NK Cell Lectin-Like Receptor Subfamily K; D011975:Receptors, Mitogen