title: [Cancer microenvironment affects biological properties of tumor cells--tumor as an embryologic problem?].
abstract: Mutual epithelial-mesenchymal interaction represents a fundamental control mechanism during the development of organs and tissues. This review article demonstrates the importance of such interaction for tumor formation where it influences the biological properties of cancer stem cell and tumor itself. The teratoma and melanoma are employed as examples to demonstrate the influence of embryonic microenvironment on the biological properties of tumor, mainly on its potential to metastasize. The manipulation of cancer microenvironment represents the perspective therapeutic tool for cancer treatment in future.
authors.affiliation: 1. Lékarská fakulta, Anatomický ustav, Univerzita Karlova v Praze. karel.smetana@lf1.cuni.cz
authors.forename: Karel
authors.initials: K
authors.lastname: Smetana
authors.forename: Barbora
authors.initials: B
authors.lastname: Dvoránková
authors.forename: Lukás
authors.initials: L
authors.lastname: Lacina
authors.forename: Eliska
authors.initials: E
authors.lastname: Krejcí
authors.forename: Milos
authors.initials: M
authors.lastname: Grim
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008545:Melanoma / Q000196:embryology; D009369:Neoplasms / Q000196:embryology* / Q000503:physiopathology; D014411:Neoplastic Stem Cells / Q000502:physiology*; D013724:Teratoma / Q000196:embryology