title: Prevalence of human herpesvirus 8 DNA in peripheral blood mononuclear cells of acute and chronic leukemia patients in Taiwan.
abstract: Human herpesvirus 8 (HHV-8) is associated with the development of Kaposi's sarcoma and several other human malignancies. The prevalence of HHV-8 DNA in peripheral blood mononuclear cells (PBMCs) in Taiwanese leukemia populations has not been investigated. In this study, HHV-8 DNA was extracted from PBMCs, and detected in 10.29% of the leukemia cases and 8.94% of the relatives' cases. In addition, the prevalence of HHV-8 DNA in PBMCs was nonsignificantly associated with gender, age and leukemia subtypes. The study examines the prevalence of HHV-8 DNA in PBMCs in Taiwanese leukemia and can be applied in further epidemiological studies.
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.
authors.forename: Chao-Hsien
authors.initials: CH
authors.lastname: Chen
authors.forename: Chun-Pin
authors.initials: CP
authors.lastname: Chang
authors.forename: Fang-Yan
authors.initials: FY
authors.lastname: Wu
authors.forename: Chao-Li
authors.initials: CL
authors.lastname: Liu
authors.forename: Ching-Tien
authors.initials: CT
authors.lastname: Peng
authors.forename: Cheng-Wen
authors.initials: CW
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D001769:Blood / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007938:Leukemia / Q000150:complications*; D007963:Leukocytes, Mononuclear / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004279:DNA, Viral