title: Hippocampal ripples and memory consolidation.
abstract: During slow wave sleep and quiet wakefulness, the hippocampus generates high frequency field oscillations (ripples) during which pyramidal neurons replay previous waking activity in a temporally compressed manner. As a result, reactivated firing patterns occur within shorter time windows propitious for synaptic plasticity within the hippocampal network and in downstream neocortical structures. This is consistent with the long-held view that ripples participate in strengthening and reorganizing memory traces, possibly by mediating information transfer to neocortical areas. Recent studies have confirmed that ripples and associated neuronal reactivations play a causal role in memory consolidation during sleep and rest. However, further research will be necessary to better understand the neurophysiological mechanisms of memory consolidation, in particular the selection of reactivated assemblies, and the functional specificity of awake ripples.
authors.affiliation: CNRS-Collège de France, LPPA, UMR7152, 11 place Marcelin Berthelot, 75005 Paris, France.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Girardeau
authors.forename: Michaël
authors.initials: M
authors.lastname: Zugaro
mesh_terms: D000818:Animals; D058256:Brain Waves / Q000502:physiology*; D004569:Electroencephalography; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology; D014851:Wakefulness / Q000502:physiology