title: Antihyperlipidemic and body fat-lowering effects of silk proteins with different fibroin/sericin compositions in mice fed with high fat diet.
abstract: The effect of silk protein with different fibroin/sericin compositions on body weight and lipid metabolism in high fat-fed mice was investigated. The animals were given experimental diets for 6 weeks: normal control (NC), high fat (HF) and high fat diet supplemented with F100 (pure fibroin, HF-F100), F81 (81:19 fibroin/sericin, w/w, HF-F81) or F50 (50:50 fibroin/sericin, w/w, HF-F50). The silk protein-fed mice showed markedly reduced body weight and enhanced lipid profile relative to the HF group. In general, the amount of body fat, triglyceride and total plasma cholesterol levels, atherogenic index and free fatty acid level tended to decrease, while the HDL-cholesterol level increased, with increased amount of sericin in the diet. This hypolipidemic effect was partly due to increased fecal lipid excretion, inhibition of lipogenesis and regulation of adipokine production. These findings illustrate that silk protein, particularly sericin, may be beneficial in the prevention of high fat diet-induced hyperlipidemia and obesity.
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Chung-Won
authors.initials: CW
authors.lastname: Seo
authors.forename: In Chul
authors.initials: IC
authors.lastname: Um
authors.forename: Catherine W
authors.initials: CW
authors.lastname: Rico
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Kang
mesh_terms: D054392:Adipokines / Q000097:blood; D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D005349:Fibroins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects; D047030:Sericins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D047011:Silk; D015430:Weight Gain
chemical_list: D054392:Adipokines; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D047030:Sericins; D047011:Silk; D005349:Fibroins