title: A case of intracranial saccular aneurysm after primary varicella zoster virus infection.
abstract: We report a case of intracranial saccular aneurysm that developed 3years after post-varicella ischemic stroke. A 6-year-old girl without apparent immunologic defects presented with right hemiparesis and expressive aphasia 1month after chickenpox. Her magnetic resonance imaging scans revealed left basal ganglia infarction because of left lenticulostriate artery occlusion. Although her neurologic symptoms improved gradually, segmental irregular narrowing remained in the A1 and M1 segments of the left anterior and middle cerebral arteries, respectively. Three years later, the follow-up magnetic resonance angiography indicated saccular aneurysm in the anterior communicating artery and the anti-VZV IgG antibody index in the cerebrospinal fluid was elevated. Subclinical reactivation of VZV and the segmental vascular narrowing might cause intracranial aneurysm, even in immunocompetent children.
authors.affiliation: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan. kawatani@u-fukui.ac.jp
authors.forename: Masao
authors.initials: M
authors.lastname: Kawatani
authors.forename: Akio
authors.initials: A
authors.lastname: Nakai
authors.forename: Takashi
authors.initials: T
authors.lastname: Okuno
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tsukahara
authors.forename: Yusei
authors.initials: Y
authors.lastname: Ohshima
authors.forename: Mitsufumi
authors.initials: M
authors.lastname: Mayumi
mesh_terms: D002644:Chickenpox / Q000150:complications* / Q000473:pathology; D002648:Child; D005260:Female; D014645:Herpesvirus 3, Human; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology* / Q000821:virology*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D020521:Stroke / Q000473:pathology / Q000821:virology*