title: Continuous femoral nerve blocks: varying local anesthetic delivery method (bolus versus basal) to minimize quadriceps motor block while maintaining sensory block.
abstract: BACKGROUND
  Whether the method of local anesthetic administration for continuous femoral nerve blocks--basal infusion versus repeated hourly bolus doses--influences block effects remains unknown.
  
  
  METHODS
  Bilateral femoral perineural catheters were inserted in volunteers (n = 11). Ropivacaine 0.1% was concurrently administered through both catheters: a 6-h continuous 5 ml/h basal infusion on one side and 6 hourly bolus doses on the contralateral side. The primary endpoint was the maximum voluntary isometric contraction (MVIC) of the quadriceps femoris muscle at hour 6. Secondary endpoints included quadriceps MVIC at other time points, hip adductor MVIC, and cutaneous sensation 2 cm medial to the distal quadriceps tendon in the 22 h after initiation of local anesthetic administration.
  
  
  RESULTS
  Quadriceps MVIC for limbs receiving 0.1% ropivacaine as a basal infusion declined by a mean (SD) of 84% (19) compared with 83% (24) for those receiving 0.1% ropivacaine as repeated bolus doses between baseline and hour 6 (paired t test P = 0.91). Intrasubject comparisons (left vs. right) also reflected a lack of difference: the mean basal-bolus difference in quadriceps MVIC at hour 6 was -1.1% (95% CI -22.0-19.8%). The similarity did not reach the a priori threshold for concluding equivalence, which was the 95% CI decreasing within ± 20%. There were similar minimal differences in the secondary endpoints during local anesthetic administration.
  
  
  CONCLUSIONS
  This study did not find evidence to support the hypothesis that varying the method of local anesthetic administration--basal infusion versus repeated bolus doses--influences continuous femoral nerve block effects to a clinically significant degree.
authors.affiliation: Department of Anesthesiology, University of California San Diego, San Diego, California, USA.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Charous
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Madison
authors.forename: Preetham J
authors.initials: PJ
authors.lastname: Suresh
authors.forename: NavParkash S
authors.initials: NS
authors.lastname: Sandhu
authors.forename: Vanessa J
authors.initials: VJ
authors.lastname: Loland
authors.forename: Edward R
authors.initials: ER
authors.lastname: Mariano
authors.forename: Michael C
authors.initials: MC
authors.lastname: Donohue
authors.forename: Pascual H
authors.initials: PH
authors.lastname: Dutton
authors.forename: Eliza J
authors.initials: EJ
authors.lastname: Ferguson
authors.forename: Brian M
authors.initials: BM
authors.lastname: Ilfeld
mesh_terms: D000293:Adolescent; D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000494:pharmacology; D002404:Catheterization; D004558:Electric Stimulation; D023381:Endpoint Determination; D005260:Female; D005267:Femoral Nerve; D007839:Functional Laterality; D006801:Humans; D007260:Infusion Pumps; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D009068:Movement / Q000187:drug effects*; D053580:Muscle Strength / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects; D009407:Nerve Block / Q000379:methods*; D018401:Sample Size; D012677:Sensation / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local