title: Case-controlled study on risk factors for the development of constipation in hospitalized patients.
abstract: Constipation is a common problem in hospitalized patients; however, the relative risks of its development with various factors have not been clarified. To clarify the risk factors associated with constipation, we performed a case-controlled study of 165 hospitalized patients who were not laxative users on admission. They were divided into case (n=35) and control (n=130) groups according to laxative administration during hospitalization. Comparison of the patient backgrounds in the two groups revealed significant differences in the activities of daily living, length of fasting, rest level on admission, cerebrovascular disease, and administration of hypnotics. Multiple logistic regression analysis using these five factors as autonomous variables showed that administration of hypnotics (odds ratio, 2.79; 95% confidence interval, 1.10-7.06; p=0.031) was significantly related to laxative use. Therefore, the administration of hypnotics may be the principal cause of constipation development in hospitalized patients and they should be used with caution.
authors.affiliation: Department of Pharmacy, Kitakyushu City Yahata Hospital.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ueki
authors.forename: Keiko
authors.initials: K
authors.lastname: Nagai
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Ooe
authors.forename: Mihoko N
authors.initials: MN
authors.lastname: Nakashima
authors.forename: Koyo
authors.initials: K
authors.lastname: Nishida
authors.forename: Junzo
authors.initials: J
authors.lastname: Nakamura
authors.forename: Mikiro
authors.initials: M
authors.lastname: Nakashima
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders; D003248:Constipation / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
chemical_list: D006993:Hypnotics and Sedatives