title: Integrin-mediated type IV secretion by Helicobacter: what makes it tick?
abstract: Helicobacter pylori (Hp) employs a multi-component type IV secretion system (T4SS) to secrete the effector protein CagA into the cytosol of infected host cells. A longstanding challenge has been to identify the host cell receptor(s) involved. Two recent studies have independently unveiled human β(1) integrin as the receptor but are divided over which T4SS proteins bind to β(1) integrin. Here we revisit the two models in light of previous findings and recent progress in the field. More concerted efforts are required to fully understand the complex T4SS mechanisms that underpin Hp pathogenesis.
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Australia.
authors.forename: Ralf
authors.initials: R
authors.lastname: Schuelein
authors.forename: Paige
authors.initials: P
authors.lastname: Everingham
authors.forename: Terry
authors.initials: T
authors.lastname: Kwok
mesh_terms: D000942:Antigens, Bacterial / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D016480:Helicobacter pylori / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D039641:Integrin beta Chains / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D011485:Protein Binding; D021381:Protein Transport; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D039641:Integrin beta Chains; D026901:Membrane Transport Proteins; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori