title: [Study of mutagenic activity of hexachlorocyclohexane and products of its microbial degradation].
abstract: Mutagenic activity of hexachlorcyclohexane (HCH) was investigated. As is known, gamma-isomer of HCH has insecticidal properties. The strains of microorganisms of genera Pseudomonas, Stenotrophomonas, Bacillus decomposing HCH into 46.3-86.7% from initial quantity have been selected. Microbial HCH destruction by investigated strains made changes of pesticide genetic activity: in most cases in condition of intermediate action the quantity of mutations S. typhimurium TA 100 and S. typhimurium TA 98 have decreased 1.2-1.5 times in comparison with initial substance. In a single case after HCH transformation by strain P. putida 1 the intermediates have increased the mutation frequency 1.9 times. The obtained results are necessary for selection of the most promising strains-decomposers as a basis of biopreparations for remediation of HCH polluted soils.
authors.forename: H O
authors.initials: HO
authors.lastname: Iutyns'ka
authors.forename: N A
authors.initials: NA
authors.lastname: Iamborko
authors.forename: A A
authors.initials: AA
authors.lastname: Pindrus
mesh_terms: D001410:Bacillus megaterium / Q000254:growth & development / Q000302:isolation & purification; D001673:Biodegradation, Environmental; D001556:Hexachlorocyclohexane / Q000737:chemistry / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D010575:Pesticides / Q000737:chemistry / Q000633:toxicity*; D016958:Pseudomonas putida / Q000254:growth & development / Q000302:isolation & purification; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012988:Soil Microbiology; D020615:Stenotrophomonas maltophilia / Q000254:growth & development / Q000302:isolation & purification
chemical_list: D009153:Mutagens; D010575:Pesticides; D001556:Hexachlorocyclohexane