title: Comparison of capability of dynamic O₂-enhanced MRI and quantitative thin-section MDCT to assess COPD in smokers.
abstract: OBJECTIVE
  The purpose of this study was to directly and prospectively compare the capability of dynamic O(2)-enhanced MRI and quantitatively assessed thin-section MDCT to assess smokers' COPD in a large prospective cohort.
  
  
  METHODS
  The GOLD criteria for smokers were used to classify 187 smokers into four clinical stage groups as follows: smokers without COPD (n=56) and with mild (n=54), moderate (n=52) and severe or very severe COPD (n=24). All smokers underwent dynamic O(2)-enhanced MRI, MDCT and pulmonary function tests. Mean relative enhancement ratio and mean wash-in time on MRI and CT-based functional lung volume (CT-based FLV) as well as the ratio of airway wall area to total airway area on MDCT were computationally calculated. Then, all indexes were significantly correlated with functional parameters. To determine the efficacy of all indexes for clinical stage classification, the indexes for the four clinical groups were statistically compared by using Tukey's honestly significant difference multiple comparison test.
  
  
  RESULTS
  All indexes had significant correlations with functional parameters (p<0.0001). All indexes except CT-based FLV in all groups had significant differences each other (p<0.05).
  
  
  CONCLUSIONS
  Dynamic O(2)-enhanced MRI for assessment of COPD in smokers is potentially as efficacious as quantitatively assessed thin-section MDCT.
authors.affiliation: Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan. yoshiharuohno@aol.com
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Ohno
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Koyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Aoyama
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Onishi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takenaka
authors.forename: Sumiaki
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Kazuro
authors.initials: K
authors.lastname: Sugimura
mesh_terms: D000368:Aged; D015897:Comorbidity; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007564:Japan / Q000453:epidemiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012907:Smoking / Q000453:epidemiology*; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*
chemical_list: D003287:Contrast Media; D010100:Oxygen