title: Synthesis and biological evaluation of dibenz[b,f][1,5]oxazocine derivatives for agonist activity at κ-opioid receptor.
abstract: A short and high yield synthetic route to dibenz[b,f][1,5]oxazocines has been developed using Pd catalyzed intramolecular cycloamination reaction. Receptor binding assay using [125I]-dynorphin demonstrated that one of the derivative, 5b showed selective κ-opioidergic property.
authors.affiliation: Chemistry Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700 032, India.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Mitra
authors.forename: Tuhin Suvro
authors.initials: TS
authors.lastname: Banerjee
authors.forename: Sandip K
authors.initials: SK
authors.lastname: Hota
authors.forename: Debleena
authors.initials: D
authors.lastname: Bhattacharya
authors.forename: Sumantra
authors.initials: S
authors.lastname: Das
authors.forename: Partha
authors.initials: P
authors.lastname: Chattopadhyay
mesh_terms: D000586:Amination; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D002384:Catalysis; D049109:Cell Proliferation / Q000187:drug effects; D005910:Glioma / Q000201:enzymology; D051379:Mice; D008807:Mice, Inbred BALB C; D008958:Models, Molecular; D015394:Molecular Structure; D010079:Oxazocines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D010079:Oxazocines; D017473:Receptors, Opioid, kappa; C559781:dibenz(b,f)(1,5)oxazocine; D010165:Palladium