title: Enteroviral infection of a cardiac prosthetic device.
abstract: BACKGROUND
  Identification of the causative pathogen may be challenging in culture negative infective endocarditis (IE).
  
  
  METHODS
  A 4 month-old 21-trisomic boy with congenital atrioventricular septal defect presented 3 episodes of dehiscence of his prosthetic patch, attributed to IE. He presented heart failure, but neither fever, nor inflammatory syndrome.
  
  
  RESULTS
  Surgical and histopathological findings confirmed the diagnosis of IE, but blood cultures remained sterile. Extensive work up failed to demonstrate bacterial or fungal etiology. Coxsackie B2 virus was cultured from the excised patch, nasopharyngeal secretions and stools.
  
  
  CONCLUSIONS
  Viral IE has only been described in animal models. This case is the first reported probable human viral IE. We suggest that a viral etiology should be considered in case of culture negative IE.
authors.affiliation: Pediatric Infectious Disease Unit, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium. sophie.blumental@ulb.ac.be
authors.forename: Sophie
authors.initials: S
authors.lastname: Blumental
authors.forename: Marijke
authors.initials: M
authors.lastname: Reynders
authors.forename: Ariane
authors.initials: A
authors.lastname: Willems
authors.forename: Dominique
authors.initials: D
authors.lastname: Biarent
authors.forename: Ruth
authors.initials: R
authors.lastname: Duttman
authors.forename: Philippe
authors.initials: P
authors.lastname: Lepage
authors.forename: Anne
authors.initials: A
authors.lastname: Vergison
mesh_terms: D004696:Endocarditis / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D004699:Endocardium / Q000473:pathology; D029822:Enterovirus B, Human / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D005243:Feces / Q000821:virology; D006350:Heart Valve Prosthesis / Q000009:adverse effects* / Q000821:virology; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000821:virology; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000473:pathology / Q000821:virology*