title: Influence of non-Newtonian properties of blood on the wall shear stress in human atherosclerotic right coronary arteries.
abstract: The objective of this work is to investigate the effect of non-Newtonian properties of blood on the wall shear stress (WSS) in atherosclerotic coronary arteries using both Newtonian and non-Newtonian models. Numerical simulations were performed to examine how the spatial and temporal WSS distributions are influenced by the stenosis size, blood viscosity, and flow rate. The computational results demonstrated that blood viscosity properties had considerable effect on the magnitude of the WSS, especially where disturbed flow was observed. The WSS distribution is highly non-uniform both temporally and spatially, especially in the stenotic region. The maximum WSS occurred at the proximal side of the stenosis, near the outer wall in the curved artery with no stenosis. The lumen area near the inner wall distal to the stenosis region experienced a lower WSS during the entire cardiac cycle. Among the factors of stenosis size, blood viscosity, and flow rate, the size of the stenosis has the most significant effect on the spatial and temporal WSS distributions qualitatively and quantitatively.
authors.affiliation: Department of Mathematics, Monmouth University, West Long Branch, NJ 07764, USA.
authors.forename: Biyue
authors.initials: B
authors.lastname: Liu
authors.forename: Dalin
authors.initials: D
authors.lastname: Tang
mesh_terms: D050197:Atherosclerosis / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology*; D018056:Hemorheology / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D013314:Stress, Mechanical; D013997:Time Factors