title: Cerium ammonium nitrate-catalyzed multicomponent reaction for efficient synthesis of functionalized tetrahydropyridines.
abstract: A highly atom-economic one-pot synthesis of functionalized tetrahydropyridines by a multicomponent condensation reaction of β-keto ester, two equivalents of aromatic aldehyde, and two equivalents of amine in the presence of a catalytic amount of cerium ammonium nitrate (CAN) is reported. In this way, a series of pharmacologically interesting substituted piperidine derivatives were obtained in moderate to good yields at room temperature.
authors.affiliation: The College of Chemistry & Material Science, Hebei Normal University, Shijiazhuang, China.
authors.forename: Hong-Juan
authors.initials: HJ
authors.lastname: Wang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Mo
authors.forename: Zhan-Hui
authors.initials: ZH
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D002563:Cerium / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015394:Molecular Structure; D009566:Nitrates / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis*
chemical_list: D009566:Nitrates; D011725:Pyridines; C032786:cerium nitrate; D002563:Cerium; C006568:ammonium nitrate