title: Type IV reaction due to phenylephrine administered nasally with cross-reactivity with ethylephrine.
abstract: Type IV hypersensitivity eye reactions have been described after the administration of the sympathomimetic agent phenylephrine. We report the case of an atopic woman who developed nasal congestion and discharge, dysphagia, and dyspnea 1 hour after the administration of Stopcold pills and Disneumon Pernasal nasal spray for otitis. The same symptoms reappeared after the accidental administration of Rinobanedif ointment in the nasal mucosa. Skin patch tests were performed with a standard True Test panel, preservatives, Disneumon Pernasal, pseudoephedrine, eyedrops (tropicamide, cyclopentolate, and phenylephrine), and other sympathomimetic agents. The patient also underwent oral, ocular, and nasal controlled challenges with the same drugs. Finally, patch tests were performed in 11 controls with phenylephrine and ethylephrine. Our patient had a positive outcome in patch testing with nickel sulphate, fragrance mix, phenylephrine, and ethylephrine. To our knowledge, this is the first report of a type IV reaction to nasally administered phenylephrine with cross-reactivity with ethylephrine detected by patch testing.
authors.affiliation: Department of Allergology and Clinical Immunology, Infanta Cristina University Hospital, Badajoz, Spain. pbg01ba@saludalia.com
authors.forename: P
authors.initials: P
authors.lastname: Bobadilla-González
authors.forename: I
authors.initials: I
authors.lastname: Pérez-Rangel
authors.forename: J M
authors.initials: JM
authors.lastname: García-Menaya
authors.forename: S
authors.initials: S
authors.lastname: Sánchez-Vega
authors.forename: C
authors.initials: C
authors.lastname: Cordobés-Durán
authors.forename: M A
authors.initials: MA
authors.lastname: Zambonino-Carreiras
mesh_terms: D000281:Administration, Intranasal; D003429:Cross Reactions; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005039:Etilefrine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D010328:Patch Tests; D010656:Phenylephrine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013566:Sympathomimetics / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D013566:Sympathomimetics; D010656:Phenylephrine; D005039:Etilefrine