title: Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria.
abstract: New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of central nervous system lesions in space and time has been simplified, and in some circumstances dissemination in space and time can be established by a single scan. These revisions simplify the Criteria, preserve their diagnostic sensitivity and specificity, address their applicability across populations, and may allow earlier diagnosis and more uniform and widespread use.
authors.affiliation: Department of Neurology, Free University, Amsterdam, the Netherlands. ch.polman@vumc.nl
authors.forename: Chris H
authors.initials: CH
authors.lastname: Polman
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Reingold
authors.forename: Brenda
authors.initials: B
authors.lastname: Banwell
authors.forename: Michel
authors.initials: M
authors.lastname: Clanet
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Cohen
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Fujihara
authors.forename: Eva
authors.initials: E
authors.lastname: Havrdova
authors.forename: Michael
authors.initials: M
authors.lastname: Hutchinson
authors.forename: Ludwig
authors.initials: L
authors.lastname: Kappos
authors.forename: Fred D
authors.initials: FD
authors.lastname: Lublin
authors.forename: Xavier
authors.initials: X
authors.lastname: Montalban
authors.forename: Paul
authors.initials: P
authors.lastname: O'Connor
authors.forename: Magnhild
authors.initials: M
authors.lastname: Sandberg-Wollheim
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Waubant
authors.forename: Brian
authors.initials: B
authors.lastname: Weinshenker
authors.forename: Jerry S
authors.initials: JS
authors.lastname: Wolinsky
mesh_terms: D042241:Early Diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis*; D012680:Sensitivity and Specificity