title: Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid.
abstract: CXCL13 in cerebrospinal fluid (CSF) could be an important component for diagnosing Lyme neuroborreliosis (LNB). Levels of intrathecal CXCL13 were determined for 58 LNB patients and 210 controls; sensitivity was 88% and specificity was 89% (cutoff, 250 pg of CXCL13/ml of CSF). Elevated levels of CXCL13 can aid in the diagnosis of LNB, but levels should be interpreted with care.
authors.affiliation: Department of Medical Microbiology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, Netherlands. N.D.van_Burgel@LUMC.nl
authors.forename: N D
authors.initials: ND
authors.lastname: van Burgel
authors.forename: F
authors.initials: F
authors.lastname: Bakels
authors.forename: A C M
authors.initials: AC
authors.lastname: Kroes
authors.forename: A P
authors.initials: AP
authors.lastname: van Dam
mesh_terms: D000328:Adult; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D054382:Chemokine CXCL13 / Q000134:cerebrospinal fluid*; D002648:Child; D002675:Child, Preschool; D019411:Clinical Laboratory Techniques / Q000379:methods*; D003937:Diagnosis, Differential; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: C110663:CXCL13 protein, human; D054382:Chemokine CXCL13