title: Pd-catalyzed decarboxylative coupling of propiolic acids: one-pot synthesis of 1,4-disubstituted 1,3-diynes via Sonogashira-homocoupling sequence.
abstract: One-pot synthesis of symmetric 1,4-disubstituted 1,3-diynes from iodoarenes and propiolic acid via Sonogashira reaction followed by Pd-catalyzed decarboxylative homocoupling is developed in high yields. Also, this system allows the one-pot synthesis of unsymmetric 1,4-disubstituted 1,3-diynes by cross-coupling of two different 3-substituted propiolic acids.
authors.affiliation: Department of Chemistry, University of Ulsan, Ulsan, 680-749, Republic of Korea.
authors.forename: Jihye
authors.initials: J
authors.lastname: Park
authors.forename: Eonjeong
authors.initials: E
authors.lastname: Park
authors.forename: Aejin
authors.initials: A
authors.lastname: Kim
authors.forename: Seul-A
authors.initials: SA
authors.lastname: Park
authors.forename: Youngil
authors.initials: Y
authors.lastname: Lee
authors.forename: Ki-Whan
authors.initials: KW
authors.lastname: Chi
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Jung
authors.forename: In Su
authors.initials: IS
authors.lastname: Kim
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents / Q000737:chemistry; D053280:Diynes / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011422:Propionates / Q000737:chemistry*
chemical_list: D000480:Alkynes; D003432:Cross-Linking Reagents; D053280:Diynes; D011422:Propionates; D010165:Palladium; C011537:propiolic acid