title: Five-year clinical follow-up after sirolimus-eluting stent implantation for the treatment of coronary in-stent restenosis.
abstract: BACKGROUND
  Late vessel failure by restenosis or thrombosis is a potential limitation of drug-eluting stent implantation.
  
  
  METHODS
  We conducted a prospective 5-year clinical evaluation following implantation of sirolimus-eluting Cypher stents for in-stent restenosis regardless of the patient's symptomatic status. A complete 5-year follow-up is reported for 192 consecutive patients.
  
  
  RESULTS
  The cumulative rate of death was 5.2%, of cardiac death was 4.2%, of nonfatal myocardial infarction was 4.2%, of definite stent thrombosis was 1.0%, of probable stent thrombosis was 1.0%, of possible stent thrombosis was 2.1%, of target lesion revascularization was 9.4%, of target vessel revascularization was 13.5%, and of major adverse cardiovascular events (death of all causes, nonfatal myocardial infarction, and repeat revascularization; major adverse cardiovascular event) was 22.9%, respectively.
  
  
  CONCLUSIONS
  These results, of a comparably large series, indicate that the implantation of sirolimus-eluting Cypher stents for the treatment of coronary in-stent restenosis is effective and safe and associated with a stable clinical course in the very long term.
authors.affiliation: Department of Medicine, Division of Cardiology, Medizinische Klinik und Poliklinik, University Hospital Campus Innenstadt, Munich, Germany. Thomas.Schiele@med.uni-muenchen.de
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Schiele
authors.forename: Marcus
authors.initials: M
authors.lastname: Leibig
authors.forename: Johannes
authors.initials: J
authors.lastname: Rieber
authors.forename: Andreas
authors.initials: A
authors.lastname: König
authors.forename: Florian
authors.initials: F
authors.lastname: Krötz
authors.forename: Hae-Young
authors.initials: HY
authors.lastname: Sohn
authors.forename: Volker
authors.initials: V
authors.lastname: Klauss
mesh_terms: D000368:Aged; D019917:Blood Vessel Prosthesis Implantation; D023903:Coronary Restenosis / Q000401:mortality / Q000601:surgery*; D003331:Coronary Vessels / Q000637:transplantation*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020123:Sirolimus; D013927:Thrombosis
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus