title: Thyroid-stimulating hormone, 5-HTTLPR genotype, and antidepressant response in depressed women.
abstract: Basal serum thyroid-stimulating hormone (TSH) levels may predict antidepressant efficacy in patients with major depressive episodes (MDE), but data are inconsistent. As the SS genotype of the 5-HTTLPR polymorphism has been associated with a lower antidepressant efficacy in women with MDE, we aimed at assessing the relationship between normal basal TSH, 5-HTTLPR, and antidepressant efficacy in women. A total of 71 women and 28 men, with normal baseline TSH serum levels, hospitalized for a MDE, were assessed for 5-HTTLPR genotypes and prospectively followed for short-term antidepressant efficacy. Women with SS genotype had higher TSH levels (P=0.002) and a worse antidepressant response (P=0.046) than the women with LL/LS genotype, whereas no significant difference was shown in men. In multivariate analyses, antidepressant response in women was explained by TSH and 5-HTTLPR, but not by other variables. Further research is needed to understand the underlying mechanism explaining interactions between sex, TSH, and serotonergic function.
authors.affiliation: Department of Psychiatry, Univ Paris Sud, Assistance Publique-Hôpitaux de Paris, Bicêtre University Hospital, Le Kremlin Bicêtre, France. fgressier@wanadoo.fr
authors.forename: Florence
authors.initials: F
authors.lastname: Gressier
authors.forename: Séverine
authors.initials: S
authors.lastname: Trabado
authors.forename: Céline
authors.initials: C
authors.lastname: Verstuyft
authors.forename: Elodie
authors.initials: E
authors.lastname: Bouaziz
authors.forename: Patrick
authors.initials: P
authors.lastname: Hardy
authors.forename: Bruno
authors.initials: B
authors.lastname: Fève
authors.forename: Laurent
authors.initials: L
authors.lastname: Becquemont
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Corruble
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013972:Thyrotropin / Q000097:blood*
chemical_list: D000928:Antidepressive Agents; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D013972:Thyrotropin