title: Plasma carnitine is associated with fatigue in chronic hepatitis C but not in the irritable bowel syndrome.
abstract: BACKGROUND
  Fatigue is an important determinant of altered quality of life in patients affected by chronic hepatitis C or the irritable bowel syndrome (IBS).
  
  
  OBJECTIVE
  In this study, we aimed at determining the contributory role of plasma levels of leptin and carnitine on fatigue in chronic hepatitis C and IBS.
  
  
  METHODS
  We enrolled 81 patients with chronic hepatitis C, 42 with IBS and 44 healthy subjects. Fatigue was evaluated using the Fatigue Impact Scale questionnaire. Body composition was assessed through impedance analysis. Plasma carnitine and leptin were measured.
  
  
  RESULTS
  Fatigue scores were significantly more elevated in patients with chronic hepatitis C and IBS than in healthy subjects. Patients with chronic hepatitis C but not IBS, had significant lower plasma levels of total and free carnitine adjusted for fat mass compared with healthy subjects. In patients with chronic hepatitis C and not with IBS, fatigue scores were negatively correlated with plasma levels of carnitine. Levels of free carnitine were significantly and independently associated with the severity of fatigue in patients with chronic hepatitis C [OR=2.019, P=0.02, CI 95% (1.01-1.23)].
  
  
  CONCLUSIONS
  In patients with chronic hepatitis C, the severity of fatigue is associated with a low level of carnitine, suggesting that an oral supplementation may be effective to relieve fatigue in chronic hepatitis C. The underlying mechanism of fatigue in IBS does not seem to involve carnitine.
authors.affiliation: INSERM U895, Centre Hospitalier Universitaire of Nice-Digestive Center, Nice Cedex 3, France.
authors.forename: R
authors.initials: R
authors.lastname: Anty
authors.forename: S
authors.initials: S
authors.lastname: Marjoux
authors.forename: S
authors.initials: S
authors.lastname: Bekri
authors.forename: L
authors.initials: L
authors.lastname: DeGalleani
authors.forename: R
authors.initials: R
authors.lastname: Dainese
authors.forename: E
authors.initials: E
authors.lastname: Gelsi
authors.forename: F
authors.initials: F
authors.lastname: Cherikh
authors.forename: A
authors.initials: A
authors.lastname: Tran
authors.forename: T
authors.initials: T
authors.lastname: Piche
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition / Q000502:physiology; D002331:Carnitine / Q000097:blood*; D016022:Case-Control Studies; D017097:Electric Impedance; D005221:Fatigue / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology; D011795:Surveys and Questionnaires
chemical_list: D020738:Leptin; D002331:Carnitine