title: [Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment].
abstract: OBJECTIVE
  To study the epidemiological and clinical features of the 2009-2010 pandemic influenza in Russia.
  
  
  METHODS
  Materials from 874 patients, including postmortem samples from 287 subjects, were examined applying the AmpliSens Influenza virus A/H1-swine-FL PCR kit designed and produced by the Central Research Institute of Epidemiology. The clinical and postmortem characteristics of 68 patients who had died from influenza A/H1N1 (sw2009) were analyzed in detail.
  
  
  RESULTS
  The cause of deaths was primary virus pneumonia in most cases. The major manifestation of viral pathogenicity was impaired microcirculation leading to hemorrhage. No mutations conferring resistance to oseltamivir and arbidol were found. All A/H1N1swl viruses had genetic markers of remantadin resistance.
  
  
  CONCLUSIONS
  The reagent kits developed by the Central Research Institute of Epidemiology proved to be effective. It is necessary to set up PCR laboratories that differentially diagnose influenza and acute respiratory viral infections in health care facilities in order to make early laboratory diagnosis of influenza and to timely perform its specific therapy.
authors.forename: S B
authors.initials: SB
authors.lastname: Iatsyshina
authors.forename: A N
authors.initials: AN
authors.lastname: Minenko
authors.forename: T E
authors.initials: TE
authors.lastname: Kushakova
authors.forename: M N
authors.initials: MN
authors.lastname: Praded
authors.forename: A V
authors.initials: AV
authors.lastname: Kudriavtseva
authors.forename: G A
authors.initials: GA
authors.lastname: Shipulin
authors.forename: V V
authors.initials: VV
authors.lastname: Maleev
authors.forename: V I
authors.initials: VI
authors.lastname: Pokrovskiĭ
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003422:Critical Care / Q000379:methods*; D003937:Diagnosis, Differential; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology / Q000628:therapy / Q000821:virology; D058873:Pandemics; D012121:Respiration, Artificial; D012426:Russia / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents