title: Pseudomonas aeruginosa infection in cystic fibrosis caused by an epidemic metallo-β-lactamase-producing clone with a heterogeneous carbapenem resistance phenotype.
abstract: An epidemic IMP-13 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa clone, causing infections and even large outbreaks in Italian critical care settings, was detected in a young cystic fibrosis patient. In this patient, the chronic infection was sustained by distinct clonal sub-populations of the MBL-producing P. aeruginosa clone, either susceptible or resistant to carbapenems. These findings underscore the importance of infection prevention practices in cystic fibrosis settings and pose an important diagnostic and therapeutic challenge.
authors.affiliation: Università degli Studi di Siena, Siena, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Pollini
authors.forename: E
authors.initials: E
authors.lastname: Fiscarelli
authors.forename: C
authors.initials: C
authors.lastname: Mugnaioli
authors.forename: V
authors.initials: V
authors.lastname: Di Pilato
authors.forename: G
authors.initials: G
authors.lastname: Ricciotti
authors.forename: A S
authors.initials: AS
authors.lastname: Neri
authors.forename: G M
authors.initials: GM
authors.lastname: Rossolini
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology*; D002648:Child; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D058872:Epidemics; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D011552:Pseudomonas Infections / Q000453:epidemiology* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification*; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases