title: [A case of aromatase inhibitor-tolerant metastatic breast cancer revealing complete remission with high-dose toremifene therapy].
abstract: A 78-year-old woman diagnosed with left breast cancer (T2N1M0, Stage II B) was given breast-conserving therapy with axillary dissection. Pathological findings of the tumor were: 2.5 cm in size, invasive ductal carcinoma, nuclear grade 3, positive lymphatic invasion and pN1a. ER and PgR were both positive, and HER2 was negative. Administration of anastrozole (1 mg/day) and UFT (300 mg/day) was performed as adjuvant therapy for 8 months. However, several subcutaneous nodules appeared in the left breast and left axilla, after 11 months. Cytology and histology of nodules indicated metastatic invasive ductal carcinoma. We began high-dose toremifene therapy (120 mg/day) (HD-TOR) for treatment of recurrence and complete remission (CR), and was obtained after 8 months in all recurrent lesions. In this study, we demonstrated a case of aromatase inhibitor-tolerant metastatic breast cancer revealing CR following high-dose toremifene therapy.
authors.affiliation: Dept. of Breast Surgery, Maebashi Red Cross Hospital, Japan.
authors.forename: Sasagu
authors.initials: S
authors.lastname: Kurozumi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Takeo
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Ikeda
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
authors.forename: Izumi
authors.initials: I
authors.lastname: Takeyoshi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ito
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D012074:Remission Induction; D017312:Toremifene / Q000627:therapeutic use*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D017312:Toremifene