title: Designed hybrid scaffolds consisting of polycaprolactone microstrands and electrospun collagen-nanofibers for bone tissue regeneration.
abstract: Biomedical scaffolds used in bone tissue engineering should have various properties including appropriate bioactivity, mechanical strength, and morphologically optimized pore structures. Collagen has been well known as a good biomaterial for various types of tissue regeneration, but its usage has been limited due to its low mechanical property and rapid degradation. In this work, a new hybrid scaffold consisting of polycaprolactone (PCL) and collagen is proposed for bone tissue regeneration. The PCL enhances the mechanical properties of the hybrid scaffold and controls the pore structure. Layered collagen nanofibers were used to enhance the initial cell attachment and proliferation. The results showed that the hybrid scaffold yielded better mechanical properties of pure PCL scaffold as well as enhanced biological activity than the pure PCL scaffold did. The effect of pore size on bone regeneration was investigated using two hybrid scaffolds with pore sizes of 200 ± 20 and 300 ± 27 μm. After post-seeding for 7 days, the cell proliferation with pore size, 200 ± 20 μm, was greater than that with pore size, 300 ± 27 μm, due to the high surface area of the scaffold.
authors.affiliation: Department of Mechanical Engineering, Bio/Nanofluidics Lab, Chosun University, Gwangju 501-759, Korea.
authors.forename: Hyeongjin
authors.initials: H
authors.lastname: Lee
authors.forename: Myunggu
authors.initials: M
authors.lastname: Yeo
authors.forename: SeungHyun
authors.initials: S
authors.lastname: Ahn
authors.forename: Dong-Oan
authors.initials: DO
authors.lastname: Kang
authors.forename: Chul Ho
authors.initials: CH
authors.lastname: Jang
authors.forename: Haengnam
authors.initials: H
authors.lastname: Lee
authors.forename: Gil-Moon
authors.initials: GM
authors.lastname: Park
authors.forename: Geun Hyung
authors.initials: GH
authors.lastname: Kim
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001861:Bone Regeneration; D002478:Cells, Cultured; D003094:Collagen / Q000737:chemistry*; D055664:Electrochemical Techniques; D008422:Materials Testing; D057139:Nanofibers / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone; D003094:Collagen