title: Anticancer activity of the PR domain of tumor suppressor RIZ1.
abstract: Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer (stage III for prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity.
authors.affiliation: Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
authors.forename: Wanpeng
authors.initials: W
authors.lastname: Sun
authors.forename: Ling
authors.initials: L
authors.lastname: Qiao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Lifeng
authors.initials: L
authors.lastname: Chen
authors.forename: Binbing
authors.initials: B
authors.lastname: Ling
authors.forename: Ramaswami
authors.initials: R
authors.lastname: Sammynaiken
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
mesh_terms: D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D011495:Histone-Lysine N-Methyltransferase / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D009687:Nuclear Proteins / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D017434:Protein Structure, Tertiary / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D010446:Peptide Fragments; D012333:RNA, Messenger; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D011495:Histone-Lysine N-Methyltransferase; C093563:PRDM2 protein, human