title: Development and growth of adenomatoid odontogenic tumor related to formation and eruption of teeth.
abstract: The number of published cases of adenomatoid odontogenic tumor (AOT) has steadily increased, and about half were reported in Asian populations. Although the clinicopathologic profile of AOT has been extensively reported, factual knowledge of its pathogenesis is rudimentary at best, and there is controversy as to precisely which odontogenic epithelium it arises from. AOT is a successional tooth-associated lesion which develops during the mixed dentition. The permanent successor differs from its deciduous predecessor in that it has an eruptive pathway from the dental follicle to the gingiva, the gubernaculum dentis. With this background in mind, the present review focuses mainly on the early development of AOT. We successfully demonstrated a close spatial relationship between AOT and the gubernaculum dentis in a typical case. From further observations of the same AOT in which an enclosed permanent canine showed enamel hypoplasia, it is possible to pinpoint areas around the crown of a developing successional tooth in continuity with the gubernaculum dentis as starting points. In addition, we discuss the unifying histogenetic concept of three clinical variants, namely, pericoronal (follicular), extracoronal (extrafollicular), (see Article note) and peripheral.
authors.affiliation: Departments of Diagnostic Pathology and Oral Pathology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, Japan. ide-f@tsurumi-u.ac.jp
authors.forename: Fumio
authors.initials: F
authors.lastname: Ide
authors.forename: Kenji
authors.initials: K
authors.lastname: Mishima
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Norio
authors.initials: N
authors.lastname: Horie
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yamachika
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Satomura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shimoyama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Sakashita
authors.forename: Ichiro
authors.initials: I
authors.lastname: Saito
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kusama
mesh_terms: D000564:Ameloblastoma / Q000209:etiology / Q000473:pathology*; D003744:Dental Enamel Hypoplasia / Q000150:complications / Q000473:pathology; D003818:Dentition, Mixed; D005260:Female; D006258:Head and Neck Neoplasms / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D009805:Odontogenesis / Q000502:physiology*; D014078:Tooth Eruption