title: [The expression of EMS1 and DcR3 protein in laryngeal carcinoma and the relation between EMS1 and DcR3].
abstract: OBJECTIVE
  To investigate the expression of EMS1 and DcR3 in laryngeal carcinoma and analyze the relation of EMS1 and DcR3.
  
  
  METHODS
  The expression of EMS1 and DcR3 protein in 41 laryngeal carcinoma fresh samples and 41 para-carcinoma tissues (to cutting margin > 0.5 cm) were measured by flow cytometry, and 15 normal laryngeal mucosa samples were also studied as controls.
  
  
  RESULTS
  (1) The quantitative and qualitative expression of EMS1 and DcR3 protein in laryngeal carcinoma tissues was obviously higher than those in para-carcinoma and in normal laryngeal mucosa tissues respectively (P < 0.05). There was no significant difference between the expression of para-carcinoma and normal laryngeal mucosa tissues. (2) In laryngeal carcinoma, the expression of EMS1 and DcR3 protein was independent of patients' clinical classification, tumor size, smoking history, patients' age and sex but associated with tumor metastasis, pathological grade and clinical stage. (3) In laryngeal carcinoma, the expression of EMS1 was positively correlated with that of DcR3.
  
  
  CONCLUSIONS
  EMS1 was positively related to DcR3, which might play an important role in the carcinogenesis and development of laryngeal carcinoma by synergic effect.
authors.affiliation: Department of Otolaryngology, the Affiliated Hospital of Chengde Medical Institute, Chengde, 067000, China. llh186@163.com
authors.forename: Lianhe
authors.initials: L
authors.lastname: Li
authors.forename: Zhuoli
authors.initials: Z
authors.lastname: Yue
authors.forename: Honglue
authors.initials: H
authors.lastname: Lu
authors.forename: Yuli
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chunli
authors.initials: C
authors.lastname: Liu
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
authors.forename: Wenhui
authors.initials: W
authors.lastname: Yue
mesh_terms: D000328:Adult; D000368:Aged; D051356:Cortactin / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000378:metabolism*
chemical_list: C495868:CTTN protein, human; D051356:Cortactin; D053323:Receptors, Tumor Necrosis Factor, Member 6b; C505911:TNFRSF6B protein, human