title: Initial laboratory predictors of severe hepatitis and acute kidney injury in patients with acute hepatitis A.
abstract: The number of adult patients with acute hepatitis A (AH-A) has markedly increased during the last 10 years in Korea. Of special note, an increase in severe complications of AH-A, such as severe liver dysfunction and acute kidney injury (AKI), has emerged as a significant problem. The objective of this study was to identify the initial predictors for development of severe AH-A and AKI in AH-A. We retrospectively reviewed the medical records of 194 patients with AH-A from January 2007 to March 2009. Severe AH-A and AKI developed in 16 (9.3%) and 11 (6.4%) patients, respectively. Independent predictors for severe AH-A were low albumin [odds ratio (OR), 10.91; 95% confidence interval (CI), 2.324-51.215; P=0.002], low total cholesterol (OR, 5.54; 95% CI, 1.389-22.113; P=0.015), and elevated alanine aminotransferase (OR, 20.87; 95% CI, 4.581-95.067; P<0.001). Also, high level of C-reactive protein was independently associated with AKI occurrence in AH-A (OR, 10.91; 95% CI, 2.324-51.215; P=0.002).
authors.affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Cho
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Park
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Chung
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000821:virology*; D000328:Adult; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D016009:Chi-Square Distribution; D005260:Female; D006506:Hepatitis A / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008107:Liver Diseases; D008297:Male; D011237:Predictive Value of Tests; D012189:Retrospective Studies