title: A microwave-assisted diastereoselective multicomponent reaction to access dibenzo[c,e]azepinones: synthesis and biological evaluation.
abstract: An unprecedented microwave-assisted multicomponent strategy has been elaborated for the fast, efficient, and diastereoselective generation of the dibenzo[c,e]azepinone scaffold. The generated compounds were evaluated for their bioactivity.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
authors.forename: Vaibhav P
authors.initials: VP
authors.lastname: Mehta
authors.forename: Sachin G
authors.initials: SG
authors.lastname: Modha
authors.forename: Eelco
authors.initials: E
authors.lastname: Ruijter
authors.forename: Kristof
authors.initials: K
authors.lastname: Van Hecke
authors.forename: Luc
authors.initials: L
authors.lastname: Van Meervelt
authors.forename: Christophe
authors.initials: C
authors.lastname: Pannecouque
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Romano V A
authors.initials: RV
authors.lastname: Orru
authors.forename: Erik
authors.initials: E
authors.lastname: Van der Eycken
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D002384:Catalysis; D045744:Cell Line, Tumor; D020650:Combinatorial Chemistry Techniques; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D005622:Friend murine leukemia virus; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy; D051379:Mice; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
chemical_list: D000447:Aldehydes; D000970:Antineoplastic Agents; D001381:Azepines; D001565:Benzoates; D002264:Carboxylic Acids; D004791:Enzyme Inhibitors; D053829:Amyloid Precursor Protein Secretases