title: Genome-wide association approaches for identifying loci for human height genes.
abstract: Human height is a very heritable trait as most of other human anthropometric traits. Genome-wide association studies have thus far identified about 200 genes associated with height with a genome-wide significance. Very large meta-analyses were needed to achieve this. These 200 height genes are involved in various biologically plausible pathways for growth, but yet explain only 10% of the variance in height. So it is obvious, that the GIANT-consortium height meta-analysis leaves, as most of GWA studies, a major part of the genetic variation unexplained. Much work utilizing several different strategies and very large study cohorts are needed to identify more genes for growth.
authors.affiliation: Public Health Genomics, National Institute for Health and Welfare (THL), Biomedicum, Haartmaninkatu 8, Helsinki, Finland. markus.perola@thl.fi
authors.forename: Markus
authors.initials: M
authors.lastname: Perola
mesh_terms: D001827:Body Height / Q000235:genetics*; D005787:Gene Frequency; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D015201:Meta-Analysis as Topic; D020641:Polymorphism, Single Nucleotide