title: 1-(isoquinolin-1-yl)urea library generation via three-component reaction of 2-alkynylbenzaldoxime, carbodiimide, with electrophile.
abstract: A novel and highly efficient three-component reaction of 2-alkynylbenzaldoxime, carbodiimide, with electrophile (bromine or iodine monochloride) is disclosed, which generates 1-(4-haloisoquinolin-1-yl)ureas in good yields under mild conditions. Subsequent palladium-catalyzed Suzuki-Miyaura coupling reaction is introduced, leading to the diverse 1-(isoquinolin-1-yl)ureas.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, China.
authors.forename: Shengqing
authors.initials: S
authors.lastname: Ye
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D002234:Carbodiimides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry*; D014508:Urea / Q000737:chemistry*
chemical_list: D002234:Carbodiimides; D010091:Oximes; D011804:Quinolines; D010165:Palladium; D014508:Urea