title: Effect of dietary supplementation on the prognostic value of urinary and serum 8-isoprostaglandin F2α in chemically-induced mammary carcinogenesis in the rat.
abstract: BACKGROUND
  The aim of the present study was to assess the effects of zinc or copper and polyphenolic compounds on the 8-isoprostaglandin F2α concentration in the serum and urine of rats with mammary cancer (adenocarcinoma) induced with 7,12-dimethylbenz[a]antracene. The research focused on the kinetics of alterations in urinary 8-isoPGF2α at the early stage of carcinogenesis as well as the influence of dietary factors on the process. The impact of selected compounds on the intensity of DMBA--induced carcinogenesis was also assessed.
  
  
  CONCLUSIONS
  Administration of DMBA, a compound that inducers mammary tumors in experimental animals, increased the serum and urinary 8-isoPGF2α levels in study rats. In the rat model, diet supplementation with zinc, combined with selected polyphenolic compounds (resveratrol or genistein) yielded a statistically significant decrease in the rat serum and urinary biomarker concentration with a simultaneously significant stimulation of carcinogenesis.The results indicate that there is an inverse correlation between the intensity of DMBA-induced carcinogenicity and the level of 8-isoPGF2α in urine and serum of rats.
authors.affiliation: Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland. barbara.bobrowska@wum.edu.pl
authors.forename: Barbara
authors.initials: B
authors.lastname: Bobrowska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Tokarz
authors.forename: Sławomir
authors.initials: S
authors.lastname: Białek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Seweryn
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine; D002273:Carcinogens; D003300:Copper / Q000494:pharmacology*; D019587:Dietary Supplements; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D005260:Female; D019833:Genistein / Q000494:pharmacology; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000652:urine*; D011379:Prognosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology*
chemical_list: D014408:Biomarkers, Tumor; D002273:Carcinogens; D013267:Stilbenes; C075750:8-epi-prostaglandin F2alpha; D015127:9,10-Dimethyl-1,2-benzanthracene; D003300:Copper; D015237:Dinoprost; D019833:Genistein; D015032:Zinc; D000077185:Resveratrol