title: Cancer physics: diagnostics based on damped cellular elastoelectrical vibrations in microtubules.
abstract: This paper describes a proposed biophysical mechanism of a novel diagnostic method for cancer detection developed recently by Vedruccio. The diagnostic method is based on frequency selective absorption of electromagnetic waves by malignant tumors. Cancer is connected with mitochondrial malfunction (the Warburg effect) suggesting disrupted physical mechanisms. In addition to decreased energy conversion and nonutilized energy efflux, mitochondrial malfunction is accompanied by other negative effects in the cell. Diminished proton space charge layer and the static electric field around the outer membrane result in a lowered ordering level of cellular water and increased damping of microtubule-based cellular elastoelectrical vibration states. These changes manifest themselves in a dip in the amplitude of the signal with the fundamental frequency of the nonlinear microwave oscillator-the core of the diagnostic device-when coupled to the investigated cancerous tissue via the near-field. The dip is not present in the case of healthy tissue.
authors.affiliation: Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, 18251 Prague 8, Czech Republic. pokorny@ufe.cz
authors.forename: Jiří
authors.initials: J
authors.lastname: Pokorný
authors.forename: Clarbruno
authors.initials: C
authors.lastname: Vedruccio
authors.forename: Michal
authors.initials: M
authors.lastname: Cifra
authors.forename: Ondřej
authors.initials: O
authors.lastname: Kučera
mesh_terms: D001703:Biophysics / Q000295:instrumentation / Q000379:methods*; D016022:Case-Control Studies; D004548:Elasticity; D004560:Electricity; D004574:Electromagnetic Fields; D006801:Humans; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects*; D008872:Microwaves; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D014732:Vibration; D014867:Water / Q000737:chemistry / Q000378:metabolism
chemical_list: D014867:Water