title: The role of diclofenac and piritramide in the management of acute postoperative pain in hernioplasty.
abstract: OBJECTIVE
  The aim of the study was to compare the effects of diclofenac and piritramide in acute postoperative pain after hernioplasty.
  
  
  BACKGROUND
  In the treatment of moderate acute postoperative pain, non-steroidal anti-inflammatory drugs and opioids play the major role. The data on safety and effect of analgesia based on opioid and non-opioid drugs are still a controversial topic.
  
  
  METHODS
  We compared the first-line treatment effects of diclofenac and piritramide in 105 patients after hernioplasty in a retrospective manner. The subsequent therapy combined piritramide with diclofenac. We evaluated the intensity of pain and its relief using a visual analogue scale (VAS). We also evaluated the necessity of application of other analgesics.
  
  
  RESULTS
  One hour after the application of the first analgesic dose, we observed complete pain relief in 39.5% of patients treated with piritramide and in 19.4% of patients treated with diclofenac (chi2=5.17; p=0.02). After the use of piritramide, the pain relief (3.84 +/- 1.27 mm) was significantly higher than after diclofenac (3.34 +/- 0.77 mm). Another injection was needed in 76% and 54% of patients subjected to first-line treatment based on diclofenac and piritramide, respectively.
  
  
  CONCLUSIONS
  We observed that the first-line analgesic treatment based on piritramide was more effective when compared to that based on diclofenac (Tab. 3, Ref. 3). Full Text in free PDF www.bmj.sk.
authors.affiliation: Third Department of Surgery of the First Faculty of Medicine and University Hospital Motol, Praha, Czech Republic.
authors.forename: S
authors.initials: S
authors.lastname: Adamek
authors.forename: O
authors.initials: O
authors.lastname: Matouskova
authors.forename: P
authors.initials: P
authors.lastname: Pafko
authors.forename: O
authors.initials: O
authors.lastname: Slanar
authors.forename: F
authors.initials: F
authors.lastname: Perlik
mesh_terms: D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use*; D005260:Female; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D010892:Pirinitramide / Q000627:therapeutic use*
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D010892:Pirinitramide