title: Anti-inflammatory activity of an alkaloid from Solanum trilobatum on acute and chronic inflammation models.
abstract: The solasodine isolated from Solanum trilobatum has been examined for possible anti-inflammatory activity in acute and chronic inflammatory animal models. Solasodine (5, 30 and 75 mg kg⁻¹) exerted statistically significant and dose-dependent anti-inflammatory activity in carrageenan-induced rat paw oedema, which was similar to that of indomethacin (10 mg kg⁻¹), a known anti-inflammatory agent. At the dose of 75 mg kg⁻¹, solasodine inhibited the arachidonic acid-elicited rat paw oedema 1 h after arachidonic acid challenge. Topical application of solasodine significantly inhibited the ear inflammation induced by multiple applications of tetradecanoyl-phorbol 13-acetate. It also suppressed the volume of exudates, total leucocytes and amount of neutrophil migration into the rat pleural cavity. Administration of solasodine at a dose of 75 mg kg⁻¹ significantly inhibited the adjuvant-induced rat paw oedema. These results suggest that solasodine exerts anti-inflammatory activity, at least partly through the inhibition of cyclooxygenase and 5-lipoxygenase pathways.
authors.affiliation: Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut 250002, Uttar Pradesh, India. pandu115@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Pandurangan
authors.forename: R L
authors.initials: RL
authors.lastname: Khosa
authors.forename: S
authors.initials: S
authors.lastname: Hemalatha
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000633:toxicity; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000473:pathology; D002351:Carrageenan / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D007194:India; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology; D007962:Leukocytes / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012991:Solanaceous Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D032322:Solanum / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
chemical_list: D000893:Anti-Inflammatory Agents; D012991:Solanaceous Alkaloids; D016718:Arachidonic Acid; D002351:Carrageenan; C012037:solasodine; D013755:Tetradecanoylphorbol Acetate