title: Ceramicines E-I, new limonoids from Chisocheton ceramicus.
abstract: Five new limonoids, ceramicines E-I (1-5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D- and 2D-NMR data. Ceramicines E-I (1-5) exhibited moderate cell growth inhibitory activities on a range of cell lines (HL-60, A549, MCF7, and HCT116). The absolute structure of previously isolated ceramicine B (6) was also elucidated by circular dichroism (CD) and X-ray analysis.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
authors.forename: Chin Piow
authors.initials: CP
authors.lastname: Wong
authors.forename: Misae
authors.initials: M
authors.lastname: Shimada
authors.forename: Yuta
authors.initials: Y
authors.lastname: Nagakura
authors.forename: Alfarius Eko
authors.initials: AE
authors.lastname: Nugroho
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Kaneda
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Khalit
authors.initials: K
authors.lastname: Mohamad
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D045744:Cell Line, Tumor; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D006801:Humans; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry
chemical_list: D036701:Limonins