title: The role of interpolation in PVC-induced cardiomyopathy.
abstract: BACKGROUND
  Frequent premature ventricular complexes (PVCs) can cause cardiomyopathy. The mechanism is not known and may be multifactorial.
  
  
  OBJECTIVE
  This study assessed the role of PVC interpolation in PVC-induced cardiomyopathy.
  
  
  METHODS
  In 51 consecutive patients (14 women, age 49 ± 15 years, ejection fraction (EF) 0.49 ± 0.14) with frequent PVCs, 24-hour Holter recordings were performed. The amount of interpolation was determined and correlated with the presence of PVC-induced cardiomyopathy. In addition, parameters measured during an electrophysiology study were correlated with the Holter findings.
  
  
  RESULTS
  Fourteen of the 21 patients (67%) with cardiomyopathy had interpolated PVCs, compared with only 6 of 30 patients (20%) without PVC-induced cardiomyopathy (P <.001). Patients with interpolated PVCs had a higher PVC burden than patients without interpolation (28% ± 12% vs. 15% ± 15%; P = .002). The burden of interpolated PVCs correlated with the presence of PVC cardiomyopathy (21% ± 30% vs. 4% ± 13%; P = .008). Both PVC burden and interpolation independently predicted PVC-induced cardiomyopathy (odds ratio 1.07, 95% confidence interval 1.01 to 1.13, P = .02; and odds ratio 4.43, 95% confidence interval 1.06 to 18.48, P = .04, respectively). The presence of ventriculoatrial block at a ventricular pacing cycle length of 600 ms correlated with the presence of interpolation (P = .004). Patients with interpolation had a longer mean ventriculoatrial block cycle length than patients without interpolated PVCs (520 ± 110 ms vs. 394 ± 92 ms; P = .01).
  
  
  CONCLUSIONS
  The presence of interpolated PVCs was predictive of the presence of PVC cardiomyopathy. Interpolation may play an important role in the generation of PVC-induced cardiomyopathy.
authors.affiliation: Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Hilal
authors.initials: H
authors.lastname: Olgun
authors.forename: Miki
authors.initials: M
authors.lastname: Yokokawa
authors.forename: Timir
authors.initials: T
authors.lastname: Baman
authors.forename: Hyungjin Myra
authors.initials: HM
authors.lastname: Kim
authors.forename: William
authors.initials: W
authors.lastname: Armstrong
authors.forename: Eric
authors.initials: E
authors.lastname: Good
authors.forename: Aman
authors.initials: A
authors.lastname: Chugh
authors.forename: Frank
authors.initials: F
authors.lastname: Pelosi
authors.forename: Thomas
authors.initials: T
authors.lastname: Crawford
authors.forename: Hakan
authors.initials: H
authors.lastname: Oral
authors.forename: Fred
authors.initials: F
authors.lastname: Morady
authors.forename: Frank
authors.initials: F
authors.lastname: Bogun
mesh_terms: D009202:Cardiomyopathies / Q000209:etiology* / Q000503:physiopathology; D017115:Catheter Ablation; D018450:Disease Progression; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016277:Ventricular Function, Left; D018879:Ventricular Premature Complexes / Q000150:complications / Q000503:physiopathology* / Q000601:surgery