title: [Progress and prospect in the research of bone morphogenetic protein heterodimer].
abstract: Bone morphogenetic protein (BMP) homodimers are of significant osteoinductivity. However, their clinical application is limited because of high effective dosage. Recently, BMP heterodimers are reported to address the issue. This is a review of the researches on BMP heterodimers, including existent evidences, types and synthetic methods, biological activities in comparison to BMP homodimers and possible mechanisms, further research direction and future expectations.
authors.affiliation: Stomatology Hospital of Zhejiang University, Hangzhou 310006, China.
authors.forename: Yuanna
authors.initials: Y
authors.lastname: Zheng
authors.forename: Linhong
authors.initials: L
authors.lastname: Wang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Gu
mesh_terms: D000818:Animals; D001704:Biopolymers; D055396:Bone Morphogenetic Protein 2; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000235:genetics* / Q000494:pharmacology*; D006801:Humans; D055503:Protein Multimerization
chemical_list: C525718:BMP2 protein, human; C525819:BMP7 protein, human; D001704:Biopolymers; D055396:Bone Morphogenetic Protein 2; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins