title: Bioactive plasma-polymerized bipolar films for enhanced endothelial cell mobility.
abstract: A facile approach to a highly bio-active interface material is reported. XPS reveals that polar entities exist at the interface between PPAam and PPAac nanolayers. They induce strong dipolar orientation polarizability and cause the redistribution of charges, which results in a remarkable increase of polar surface energy and hydrophilicity of the multistack bipolar films. In particular bipolar films with amine groups on their outermost surface show strongly enhanced cellular mobility. The attachment, adhesion, proliferation, migration, and coverage of ECs are significantly enhanced on such films. They are therefore promising as vascular implant materials, and could have applications as coating materials for tissue engineering.
authors.affiliation: Key Laboratory of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, Chengdu, China.
authors.forename: Zhilu
authors.initials: Z
authors.lastname: Yang
authors.forename: Qiufen
authors.initials: Q
authors.lastname: Tu
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Xingjiang
authors.initials: X
authors.lastname: Lei
authors.forename: Tingting
authors.initials: T
authors.lastname: He
authors.forename: Hong
authors.initials: H
authors.lastname: Sun
authors.forename: Nan
authors.initials: N
authors.lastname: Huang
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000499:Allylamine / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000378:metabolism*; D002448:Cell Adhesion; D002465:Cell Movement / Q000502:physiology*; D049109:Cell Proliferation; D002478:Cells, Cultured; D003324:Coronary Artery Disease / Q000473:pathology / Q000628:therapy; D042783:Endothelial Cells / Q000166:cytology* / Q000502:physiology; D004730:Endothelium, Vascular / Q000166:cytology* / Q000502:physiology; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D056951:Photoelectron Spectroscopy; D058626:Plasma Gases; D011108:Polymers / Q000737:chemistry*; D013193:Stainless Steel / Q000737:chemistry; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D058626:Plasma Gases; D011108:Polymers; D013193:Stainless Steel; D000499:Allylamine; C006903:carbopol 940