title: Identification of two novel HLA-B*40 alleles, B*40:137 and B*40:158, in Taiwanese individuals.
abstract: Using sequence-based typing method we discovered two new HLA-B*40 variants, B*40:137 and B*40:158, in Taiwanese individuals. The sequence of B*40:137 has three nucleotide (nt) changes from B*40:21 at nt 353 (C→T), nt 355 (C→A) and nt 369 (C→T) resulting two coding changes at residue 94 (T→I) and residue 95 (L→I), whereas the sequence of B*40:158 differs from B*40:01:01 with five nt substitutes at nt 463 (C→A), nt 477 (C→G), nt 499 (T→A), nt 512 (T→G) and nt 527 (T→A) causing five amino acid exchanges at codons 140 (Y→S), 155 (R→S), 168 (S→T), 171 (L→W) and 179 (V→E). Our hypotheses on the generation of the two novel alleles are presented.
authors.affiliation: Laboratory of Immunogenetics and Cord Blood Bank, Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry, Buddhist Tzu Chi General Hospital, Buddhist Compassion Relief Tzu Chi Foundation, Hualien 970, Taiwan. edward@tzuchi.com.tw
authors.forename: K L
authors.initials: KL
authors.lastname: Yang
authors.forename: S K
authors.initials: SK
authors.lastname: Lee
authors.forename: C C
authors.initials: CC
authors.lastname: Chu
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: S
authors.initials: S
authors.lastname: Jiang
authors.forename: H M
authors.initials: HM
authors.lastname: Chiu
authors.forename: S
authors.initials: S
authors.lastname: Lin
authors.forename: Y C
authors.initials: YC
authors.lastname: Chen
authors.forename: M J
authors.initials: MJ
authors.lastname: Chen
authors.forename: Y F
authors.initials: YF
authors.lastname: Jian
authors.forename: C F
authors.initials: CF
authors.lastname: Yang
authors.forename: S Y
authors.initials: SY
authors.lastname: Yang
authors.forename: M H
authors.initials: MH
authors.lastname: Shyr
authors.forename: C L
authors.initials: CL
authors.lastname: Lin
authors.forename: P Y
authors.initials: PY
authors.lastname: Lin
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D015235:HLA-B Antigens / Q000235:genetics*; D059947:HLA-B40 Antigen; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D015235:HLA-B Antigens; D059947:HLA-B40 Antigen