title: Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy.
abstract: BACKGROUND
  Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored.
  
  
  METHODS
  Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort.
  
  
  RESULTS
  There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9 nmol/L, p-value = 0.01) than primiparous women.
  
  
  CONCLUSIONS
  Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy.
authors.affiliation: National Institute for Health and Welfare, Oulu, Finland. Adetunji.Toriola@uta.fi
authors.forename: Adetunji T
authors.initials: AT
authors.lastname: Toriola
authors.forename: Helja-Marja
authors.initials: HM
authors.lastname: Surcel
authors.forename: Anika
authors.initials: A
authors.lastname: Husing
authors.forename: Kjell
authors.initials: K
authors.lastname: Grankvist
authors.forename: Hans-Ake
authors.initials: HA
authors.lastname: Lakso
authors.forename: Helena
authors.initials: H
authors.lastname: Schock
authors.forename: Eva
authors.initials: E
authors.lastname: Lundin
authors.forename: Matti
authors.initials: M
authors.lastname: Lehtinen
authors.forename: Annekatrin
authors.initials: A
authors.lastname: Lukanova
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism; D009035:Mothers; D009994:Osmolar Concentration; D011247:Pregnancy / Q000097:blood* / Q000378:metabolism; D011261:Pregnancy Trimester, First / Q000097:blood / Q000378:metabolism; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D012739:Gonadal Steroid Hormones; D014807:Vitamin D; D007334:Insulin-Like Growth Factor I; C104450:25-hydroxyvitamin D