title: Multiple autoimmune syndrome: Hashimoto's thyroiditis, coeliac disease and systemic lupus erythematosus (SLE).
abstract: Various autoimmune diseases have association with each other but it is very rare to see multiple autoimmune diseases in one patient. Presence of more than two autoimmune diseases in one patient is known as multiple autoimmune syndrome (MAS). We report the case of an 11 years old girl who presented with history of swelling in front of the neck along with constipation, anorexia, weight gain and increasing pallor over a period of six months. Additionally she had an episodic history of joint pains and abdominal pain with no specific relation to diet, time, other gastrointestinal or genitourinary symptom. Hypothyroid goiter (Autoimmune thyroiditis, Hashimoto's thyroidits) was diagnosed by raised thyroid stimulating hormone (TSH), low T4 and presence of thyroid specific antibodies in blood. Patient was discharged on tablet Levothyroxine to which she responded well with reduction in size of the swelling and relief of the symptoms except for the joint pains and abdominal pain. To evaluate the persistent symptoms she was investigated further for other autoimmune diseases and was diagnosed to be having systemic lupus erythematosus (SLE) and Coeliac disease also. The final diagnosis was multiple autoimmune syndrome (Hashimoto's thyroiditis, Coeliac disease and SLE).
authors.affiliation: Paediatric Unit II, Dow University of Health Sciences (DUHS) and Civil Hospital, Karachi.
authors.forename: Shahbaz
authors.initials: S
authors.lastname: Latif
authors.forename: Ammarah
authors.initials: A
authors.lastname: Jamal
authors.forename: Iqbal
authors.initials: I
authors.lastname: Memon
authors.forename: Shagufta
authors.initials: S
authors.lastname: Yasmeen
authors.forename: Veena
authors.initials: V
authors.lastname: Tresa
authors.forename: Sattar
authors.initials: S
authors.lastname: Shaikh
mesh_terms: D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D002648:Child; D005260:Female; D050031:Hashimoto Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D011988:Receptors, Thyroid Hormone / Q000627:therapeutic use; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D011988:Receptors, Thyroid Hormone; D013972:Thyrotropin; D013974:Thyroxine