title: Stochastic simulations of the exponential-beta function as an assessment of the validity of the choice of the Wagner-Nelson method for the analysis of ¹³C-octanoic acid breath tests.
abstract: A compartmental model that generates the exponential-beta function μkβ(1 - e(-kt))(β - 1) e(-kt) in order to run stochastic simulations has been constructed. The mathematical considerations that lead to the development of the model and the comparison of its performance with real data sets obtained from the studies of gastric emptying in healthy volunteers using ¹³C-octanoic acid breath tests are demonstrated. Stochastic simulations have been used to introduce randomness. These confirmed the choice of an exponential-beta function to model the physiological system, as agreement was obtained between experimental and theoretical data. The comparisons were made by visual inspection only, as the intention was to demonstrate that the stochastic exponential-β model would generate the full range of observed curve shapes.
authors.affiliation: Molecular Medicine, Pfizer Global Research and Development, Sandwich, CT13 9NJ, UK. david-olivier.azulay@pfizer.com
authors.forename: David-Olivier
authors.initials: DO
authors.lastname: Azulay
authors.forename: Dominik
authors.initials: D
authors.lastname: Stunder
authors.forename: Frederick
authors.initials: F
authors.lastname: Wilson
mesh_terms: D001944:Breath Tests / Q000379:methods; D002210:Caprylates; D005746:Gastric Emptying; D006801:Humans; D015203:Reproducibility of Results; D013269:Stochastic Processes
chemical_list: D002210:Caprylates; C031492:octanoic acid