title: Role of CD3ε-mediated signaling in T-cell development and function.
abstract: Receptor-mediated signal transduction plays an important role in T-cell differentiation and function. The pre-T-cell receptor (pre-TCR) and TCR complexes are the most critical receptors for T-cell biology. Signals induced by pre-TCR and TCR in a ligand-independent or a ligand-dependent manner, respectively, are essential for thymocyte maturation. CD3 proteins, which are γ, δ, ε, and ζ polypeptides, play pivotal role in intracellular assembly, surface expression, and signal transduction via the pre-TCR and TCR complexes. Recent studies have suggested central and multiple roles for CD3ε in T-cell development and function. We review the role of the CD3ε chain in T-cell biology.
authors.affiliation: Lymphocyte Development Laboratory, Clinical Research Institute of Montreal, Quebec, Canada.
authors.forename: Vibhuti P
authors.initials: VP
authors.lastname: Dave
mesh_terms: D017252:CD3 Complex / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism
chemical_list: D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell