title: Successful treatment of cyclosporine-A-resistant cytophagic histiocytic panniculitis with tacrolimus.
abstract: A 34-year-old woman with discoid lupus erythematosus and lupus profundus was admitted to our hospital showing signs of a fever, malaise, and abdominal swelling. Diagnosis of cytophagic histiocytic panniculitis (CHP) was made based on lobular panniculitis with a hemophagocytosis. Treatment with high doses of prednisolone combined with cyclosporine A (CsA) was not effective enough. However, after changing CsA to tacrolimus (TAC), CHP improved. Our case demonstrates that TAC may be a novel therapy for CHP.
authors.affiliation: Department of Rheumatology, Ome Municipal General Hospital, 4-16-5 Higashi-Ome, Ome, Tokyo, 198-0042, Japan.
authors.forename: Yoshishige
authors.initials: Y
authors.lastname: Miyabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Murata
authors.forename: Yukari
authors.initials: Y
authors.lastname: Baba
authors.forename: Eisaku
authors.initials: E
authors.lastname: Ito
authors.forename: Kenji
authors.initials: K
authors.lastname: Nagasaka
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D004351:Drug Resistance / Q000276:immunology*; D005260:Female; D006644:Histiocytes / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015434:Panniculitis / Q000188:drug therapy* / Q000473:pathology; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus