title: Anti-tumor necrosis factor therapy in rheumatoid arthritis patients with a history of deep prosthetic joint infection: a report of four cases.
abstract: Four rheumatoid arthritis patients (three women and one man) who had a history of prosthetic joint infection were treated with anti-tumor necrosis factor (TNF) agents after treatment of the infection. The anti-TNF therapy was subsequently discontinued in three patients. The reason for discontinuation was not the reactivation of infection, but disseminated tuberculosis, Pneumocystis jiroveci pneumonia, and interstitial pneumonia, respectively. These cases suggest that a history of prosthetic joint infection may be a contraindication for treatment with anti-TNF agents.
authors.affiliation: Department of Rheumatology, Toyohashi Municipal Hospital, 50 Hakken-nishi, Aotake-cho, Toyohashi, 441-8570, Japan. yu-hr@sf.commufa.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hirano
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Kojima
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kanayama
authors.forename: Tomone
authors.initials: T
authors.lastname: Shioura
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hayashi
authors.forename: Seiji
authors.initials: S
authors.lastname: Tsuboi
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishiguro
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000075202:Contraindications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000276:immunology*; D045363:Pneumocystis carinii; D011020:Pneumonia, Pneumocystis / Q000276:immunology; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging / Q000276:immunology*; D011859:Radiography; D014376:Tuberculosis / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha