title: Mesna, doxorubicin, ifosfamide and dacarbazine chemotherapy for uterine leiomyosarcoma: a report of two cases.
abstract: The prognosis of uterine leiomyosarcoma (LMS) is notoriously poor and a standard chemotherapy for patients with uterine LMS has not yet been established. Here, we describe two patients with recurrent LMS of the uterus who were treated with mesna, doxorubicin, ifosfamide and dacarbazine chemotherapy; one achieved complete and the other partial remission.
authors.affiliation: Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, Sapporo, Japan. minobe@sap-cc.go.jp
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Minobe
authors.forename: Yukiharu
authors.initials: Y
authors.lastname: Todo
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Umazume
authors.forename: Kazuhira
authors.initials: K
authors.lastname: Okamoto
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kato
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003606:Dacarbazine / Q000008:administration & dosage / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000627:therapeutic use; D007890:Leiomyosarcoma / Q000188:drug therapy*; D015080:Mesna / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D012074:Remission Induction; D014594:Uterine Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D003606:Dacarbazine; D004317:Doxorubicin; D015080:Mesna; D007069:Ifosfamide