title: Plasminogen activator inhibitor-1 gene polymorphisms in pre-eclampsia.
abstract: Pre-eclampsia (P-EC) is a multisystem disorder of pregnancy, characterized by new-onset hypertension and proteinuria. Deregulation of the coagulation cascade and hypofibrinolysis appear to play a central role in the development of this disease. After a brief review of the genetic basis of P-EC and the role of genes encoding proteins involved in coagulation, we focus on polymorphisms of the plasminogen activator inhibitor (PAI-1) gene. The most relevant association studies between PAI-1 gene polymorphisms and P-EC are reviewed. Results indicate that the 4G/4G genotype of the -675 4G/5G polymorphism represents a weak risk factor for P-EC.
authors.affiliation: Istituto di Genetica Medica, AOUSMM Udine, Udine, Italy.
authors.forename: Angela V
authors.initials: AV
authors.lastname: D'Elia
authors.forename: Dora
authors.initials: D
authors.lastname: Fabbro
authors.forename: Lorenza
authors.initials: L
authors.lastname: Driul
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barillari
authors.forename: Diego
authors.initials: D
authors.lastname: Marchesoni
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Damante
mesh_terms: D002897:Chromosomes, Human, Pair 7; D005260:Female; D055106:Genome-Wide Association Study; D006487:Hemostasis / Q000235:genetics; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
chemical_list: D017395:Plasminogen Activator Inhibitor 1