title: Ulcerating molluscum contagiosum in a boy with relapsed acute lymphoblastic leukemia.
abstract: Molluscum contagiosum is an infectious disease presenting with flesh-colored, dome-shaped, umblicated papules. A few atypical presentations have been reported in immunodeficient patients. A 5-year-old boy with acute lymphoblastic leukemia, presented with bright white-colored papular lesions with no umblications on the chin during his continuation chemotherapy. Increased number of the lesions covered almost his entire chin in months. Topical therapies did not improve the lesions. After his bone marrow relapse, induction chemotherapy was withheld because of bronchopneumonia after febrile neutropenia. After initiation of a combination of systemic parenteral antibiotic and antifungal therapies, his parents squeezed one of his papular lesions. Meanwhile, systemic acyclovir was added to his therapy, because of herpes labialis. Despite the large spectrum of his therapies, in 1.5 months, this small lesion progressed to a large lesion with erythematous ground and a central ulceration. Etiology of the lesion could not be enlightened until a skin biopsy that was compatible with the molluscum contagiosum. A partial resolution was achieved by cryotherapy. In conclusion, molluscum contagiosum may present as an ulcerating lesion during childhood leukemia treatment. A skin biopsy should be performed for the accurate diagnosis of atypical cutaneous lesions in immunocompromised patients.
authors.affiliation: Department of Pediatrics, Ondokuz Mayis University, Medical School, Samsun, Turkey. heozyurek@yahoo.com
authors.forename: Emel
authors.initials: E
authors.lastname: Ozyürek
authors.forename: Nilgün
authors.initials: N
authors.lastname: Sentürk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kefeli
authors.forename: Olcay
authors.initials: O
authors.lastname: Güngör
authors.forename: Mehtap
authors.initials: M
authors.lastname: Akbalik
authors.forename: Fatma
authors.initials: F
authors.lastname: Aydin
authors.forename: Tunç
authors.initials: T
authors.lastname: Fişgin
authors.forename: Davut
authors.initials: D
authors.lastname: Albayrak
mesh_terms: D002675:Child, Preschool; D006801:Humans; D008297:Male; D008976:Molluscum Contagiosum / Q000209:etiology* / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012008:Recurrence; D014456:Ulcer / Q000209:etiology*