title: Nurse-administered propofol sedation is safe for patients with obstructive sleep apnea undergoing routine endoscopy: a pilot study.
abstract: BACKGROUND
  Nurse-administered propofol sedation (NAPS) is now in widespread use. The safety profile of NAPS for routine endoscopic procedures in patients with obstructive sleep apnea (OSA) is unknown.
  
  
  OBJECTIVE
  To compare outcomes of patients with and without OSA undergoing routine endoscopic procedures with NAPS and standard conscious sedation (CS) with benzodiazepines and narcotics.
  
  
  METHODS
  Retrospective cohort study.
  
  
  RESULTS
  A total of 215 patients were placed in one of four groups: OSA patients undergoing endoscopy with NAPS, OSA patients undergoing endoscopy with standard CS, non-OSA patients undergoing endoscopy with NAPS, and non-OSA patients undergoing endoscopy with standard CS. Procedures were generally accomplished faster with NAPS. There was no statistically significant difference in complication rates or overall outcomes in patients with OSA when compared to non-OSA patients when either NAPS or CS was utilized.
  
  
  CONCLUSIONS
  Routine endoscopic procedures using NAPS are safe in patients with documented OSA, with complication rates comparable to when using CS. NAPS helped to decrease procedure times in general.
authors.affiliation: Department Internal Medicine, Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, UT, USA. douglas.adler@hsc.utah.edu
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Adler
authors.forename: Chad
authors.initials: C
authors.lastname: Kawa
authors.forename: Kristen
authors.initials: K
authors.lastname: Hilden
authors.forename: John
authors.initials: J
authors.lastname: Fang
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D016292:Procedural Sedation / Q000009:adverse effects; D004724:Endoscopy; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009726:Nurses; D010865:Pilot Projects; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects* / Q000494:pharmacology; D012189:Retrospective Studies; D020181:Sleep Apnea, Obstructive / Q000150:complications*
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol