title: Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius.
abstract: Two new benzopyranones, diaportheone A (1) and B (2), were obtained via bioassay-guided isolation of the secondary metabolites from the endophytic fungus Diaporthe sp. P133 isolated from Pandanus amaryllifolius leaves. Their structures were determined from spectral analysis including mass spectrometry, 1D and 2D nuclear magnetic resonance. Both 1 and 2 inhibited the growth of the virulent strain of Mycobacterium tuberculosis H(37)Rv with minimum inhibitory concentrations of 100.9 and 3.5 μM, respectively.
authors.affiliation: University of Santo Tomas, España, Manila, Philippines.
authors.forename: Melfei E
authors.initials: ME
authors.lastname: Bungihan
authors.forename: Mario A
authors.initials: MA
authors.lastname: Tan
authors.forename: Mariko
authors.initials: M
authors.lastname: Kitajima
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kogure
authors.forename: Scott G
authors.initials: SG
authors.lastname: Franzblau
authors.forename: Thomas Edison E
authors.initials: TE
authors.lastname: Dela Cruz
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takayama
authors.forename: Maribel G
authors.initials: MG
authors.lastname: Nonato
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry* / Q000502:physiology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D031673:Pandanaceae / Q000382:microbiology*; D018515:Plant Leaves / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents