title: Fluid-induced osteolysis: modelling and experiments.
abstract: A model to calculate bone resorption driven by fluid flow at the bone-soft tissue interface is developed and used as a basis for computer calculations, which are compared to experiments where bone is subjected to fluid flow in a rat model. Previous models for bone remodelling calculations have been based on the state of stress, strain or energy density of the bone tissue as the stimulus for remodelling. We believe that there is experimental support for an additional pathway where an increase in the amount of the cells directly involved in bone removal, the osteoclasts, is caused by fluid pressure, flow velocity or other parameters related to fluid flow at the bone-soft tissue interface, resulting in bone resorption.
authors.affiliation: Department of Management and Engineering, Linköping University, Linköping, Sweden. lars.johansson@liu.se
authors.forename: Lars
authors.initials: L
authors.lastname: Johansson
authors.forename: Ulf
authors.initials: U
authors.lastname: Edlund
authors.forename: Anna
authors.initials: A
authors.lastname: Fahlgren
authors.forename: Per
authors.initials: P
authors.lastname: Aspenberg
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D020342:Finite Element Analysis; D010014:Osteolysis / Q000188:drug therapy*; D051381:Rats