title: [Assessing clinical efficacy of the generic clopidogrel "Egutromb" in roentgenosurgical practice].
abstract: The study comprised a total of ten 47-to-62-year-old (mean age 52.8±2.05 years) patients presenting with coronary artery disease. All patients underwent coronography whose findings were used to determine the indications for stenting of coronary arteries in order to correct coronary insufficiency with due regard for the international guidelines. All the patients received therapy with acetylsalicylic acid at a dose of 75-125 mg/day. As preoperative preparation in all cases the patients were given the generic clopidogrel Egitromb at a daily dose of 75 mg given 120 hours (5 days) prior to the intervention. The clinical effect of the drug was assessed by the presence or absence of relapses of cardiac angina, or the development of acute coronary syndrome within 1 month following the endovascular intervention performed. The state of the vascular-thrombocytic haemostasis was evaluated by the following parameters: spontaneous blood platelet aggregation, induced by ADP given at a dose of 5 μg/ml and 1.25 μg/ml. The obtained initial positive findings of studying clinical efficacy of the generic clopidogrel "Egitromb" manifesting itself in the absence of early stent's thromboses and relapses of cardiac angina within the first month of treatment, as well as in a significant decrease of induced blood platelet aggregation with ADP at a dose of 5 μg/ml and 1.25 μg/ml suggest the necessity of continuing further study thereof in roentgenosurgical practice.
authors.forename: V B
authors.initials: VB
authors.lastname: Loenko
authors.forename: E A
authors.initials: EA
authors.lastname: Sorokina
authors.forename: V S
authors.initials: VS
authors.lastname: Bobrov
authors.forename: N L
authors.initials: NL
authors.lastname: Demakova
authors.forename: I L
authors.initials: IL
authors.lastname: Faĭl'
authors.forename: A V
authors.initials: AV
authors.lastname: Gubenko
mesh_terms: D000077144:Clopidogrel; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D016568:Drugs, Generic / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D016568:Drugs, Generic; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine