title: Malignant (anaplastic) transformation of orbital clear cell meningioma.
abstract: A 69-year-old woman with a history of a previously resected right sphenoid wing meningioma and radiation presented with a 4-month history of a rapidly progressive right orbital swelling. MRI revealed a sphenoid wing mass extending in the right orbit and depressing the right globe. An incisional biopsy revealed a clear cell meningioma with anaplastic features. Histopathologic examination showed that the tumor was composed of sheets of polygonal cells with clear cytoplasm consistent with clear cell meningioma. Nuclear atypia with a high mitotic activity was also evident; thus, the tumor was classified as anaplastic. Clear cell meningioma is a rare form of meningioma usually located in the cerebellopontine or spinal cord areas.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Sumitra
authors.initials: S
authors.lastname: Subramanyam
authors.forename: Ted H
authors.initials: TH
authors.lastname: Wojno
authors.forename: Hans E
authors.initials: HE
authors.lastname: Grossniklaus
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000473:pathology*; D009918:Orbital Neoplasms / Q000473:pathology*