title: Analysis of single nucleotide polymorphisms in case-control studies.
abstract: Single nucleotide polymorphisms (SNPs) are the most common type of genetic variants in the human genome. SNPs are known to modify susceptibility to complex diseases. We describe and discuss methods used to identify SNPs associated with disease in case-control studies. An outline on study population selection, sample collection and genotyping platforms is presented, complemented by SNP selection, data preprocessing and analysis.
authors.affiliation: Celera Corporation, Alameda, CA, USA.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Li
authors.forename: Dov
authors.initials: D
authors.lastname: Shiffman
authors.forename: Rainer
authors.initials: R
authors.lastname: Oberbauer
mesh_terms: D016022:Case-Control Studies; D002874:Chromosome Mapping; D019295:Computational Biology; D004194:Disease / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D011786:Quality Control; D015203:Reproducibility of Results