title: Relationship between RegIV gene expression to outcomes in colorectal cancer.
abstract: BACKGROUND
  Regenerating islet-derived family members (Reg) are superfamily of calcium-dependant lectins that are expressed in the proximal gastrointestinal tract and ectopically at other sites in the setting of tissue injury. The regenerating islet-derived family member 4 (RegIV) gene has been reported in various cancers, associating with diverse functions. This study examined the relation of the relative expression of RegIV gene to clinicopathological factors and outcomes in patients with colorectal cancer (CRC).
  
  
  METHODS
  We studied surgical specimens of cancer tissue and adjacent normal mucosa obtained from 202 patients with untreated CRC. The relative expression levels of RegIV mRNA in cancer and in normal adjacent mucosa were measured by quantitative real-time reverse-transcriptase polymerase chain reaction.
  
  
  RESULTS
  RegIV gene expression was higher in cancer tissue than in adjacent normal mucosa. The multivariate analysis of clinicopathological factors for 5-year overall survival showed a higher level of RegIV gene expression was a significant independent predictor. Overall survival at 5 years differed significantly between patients with high RegIV gene expression and those with low expression.
  
  
  CONCLUSIONS
  Overexpression of the RegIV gene is considered a useful independent predictor of outcomes in patients with CRC.
authors.affiliation: Gastroenterological Center, Yokohama City University Medical Center, Minami-ku, Yokohama-shi, Kanagawa-ken, Japan.
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Numata
authors.forename: Takashi
authors.initials: T
authors.lastname: Oshima
authors.forename: Kazue
authors.initials: K
authors.lastname: Yoshihara
authors.forename: Takuo
authors.initials: T
authors.lastname: Watanabe
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Tsuchida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamagawa
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Manabu
authors.initials: M
authors.lastname: Shiozawa
authors.forename: Soichiro
authors.initials: S
authors.lastname: Morinaga
authors.forename: Makoto
authors.initials: M
authors.lastname: Akaike
authors.forename: Chikara
authors.initials: C
authors.lastname: Kunisaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Tanaka
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality; D005260:Female; D015870:Gene Expression; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D000073718:Pancreatitis-Associated Proteins; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016019:Survival Analysis
chemical_list: D037181:Lectins, C-Type; D000073718:Pancreatitis-Associated Proteins; C428528:REG4 protein, human