title: Does the bromocriptine-rebound method improve embryo quality?
abstract: OBJECTIVE
  To examine whether the bromocriptine-rebound (BR) method improves pregnancy outcomes after previous unsuccessful assisted reproductive technology (ART) attempts. PATIENTS/STUDY DESIGN: In this study we retrospectively analyzed data from a total of 121 women with normal serum prolactin (PRL) levels and a history of repeated unsuccessful ART procedures. Pregnancy outcomes and hormonal data were compared between the long protocol and BR method. Both procedures were similar, except that in the BR method, bromocriptine was administered daily from day 5 of the preceding cycle until 7 days before ovarian stimulation.
  
  
  RESULTS
  The number of fertilized oocytes, cleaved embryos and transplant embryos were significantly higher with the BR method than with the long protocol even though the numbers of retrieved oocyte were same in both groups. The ratio of the good embryos, the clinical pregnancy rate was higher with the BR method than with the long protocol. The embryo score with the BR method were significantly higher than that with the long protocol.
  
  
  CONCLUSIONS
  BR method could provide the better embryos and improve the transplantation rate in women with previous unsuccessful ART attempts.
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Moride
authors.forename: Akira
authors.initials: A
authors.lastname: Kuwahara
authors.forename: Mizuho
authors.initials: M
authors.lastname: Yamashita
authors.forename: Yu
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Toshiya
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yasui
authors.forename: Minoru
authors.initials: M
authors.lastname: Irahara
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000008:administration & dosage*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011388:Prolactin / Q000097:blood; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D017211:Treatment Failure
chemical_list: D001971:Bromocriptine; D011388:Prolactin