title: Single center experience of capsule endoscopy in patients with obscure gastrointestinal bleeding.
abstract: OBJECTIVE
  To identify optimum timing to maximize diagnostic yield by capsule endoscopy (CE) in patients with obscure gastrointestinal bleeding (OGIB).
  
  
  METHODS
  We identified patients who underwent CE at our institution from August 2003 to December 2009. Patient medical records were reviewed to determine type of OGIB (occult, overt), CE results and complications, and timing of CE with respect to onset of bleeding.
  
  
  RESULTS
  Out of 385 patients investigated for OGIB, 284 (74%) had some lesion detected by CE. In 222 patients (58%), definite lesions were detected that could unequivocally explain OGIB. Small bowel ulcer/erosions secondary to Crohn's disease, tuberculosis or non-steroidal anti-inflammatory agent use were the commonest lesions detected. Patients with overt GI bleeding for < 48 h before CE had the highest diagnostic yield (87%). This was significantly greater (P < 0.05) compared to that in patients with overt bleeding prior to 48 h (68%), as well as those with occult OGIB (59%).
  
  
  CONCLUSIONS
  We established the importance of early CE in management of OGIB. CE within 48 h of overt bleeding has the greatest potential for lesion detection.
authors.affiliation: Institute of Gastroenterology, Apollo Gleneagles Hospital, 58 Canal Circular Road, Kolkata-700054, India. mkgkolkata@gmail.com
authors.forename: Mahesh Kumar
authors.initials: MK
authors.lastname: Goenka
authors.forename: Shounak
authors.initials: S
authors.lastname: Majumder
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kumar
authors.forename: Pradeepta Kumar
authors.initials: PK
authors.lastname: Sethy
authors.forename: Usha
authors.initials: U
authors.lastname: Goenka
mesh_terms: D053704:Capsule Endoscopy / Q000379:methods*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D012189:Retrospective Studies