title: Mid-luteal progesterone concentrations are associated with live birth rates during ovulation induction.
abstract: This retrospective study investigated whether mid-luteal serum progesterone concentrations are associated with live birth rates in women with WHO group II anovulatory infertility undergoing ovulation induction. Data were from women (n=335) stimulated with gonadotrophins using a low-dose step-up protocol, of which women with presumptive ovulation (n=279), defined as a mid-luteal progesterone concentration ⩾7.9ng/ml (⩾25nmol/l; range 7.9-194ng/ml) were included. Of the women with presumptive ovulation, 57 (20.4%) had a live birth and their serum mid-luteal progesterone concentration was significantly (P=0.016) higher than that of the non-live birth group. There were significant associations between the number of large (⩾15mm) and medium-sized follicles (12-14mm) at human chorionic gonadotrophin administration and the mid-luteal progesterone concentration (P<0.001), while the total number of large and medium-sized follicles was not significantly associated with live birth rate. In conclusion, mid-luteal progesterone concentrations above the cut-off values currently used for defining ovulation were positively associated with live birth rates in normogonadotrophic anovulatory women undergoing ovulation induction with gonadotrophins. The mid-luteal progesterone concentration, apart from being a consequence of the number of corpora lutea, may also reflect the quality of the follicle/oocyte/corpus luteum. Measurement of blood concentration of the steroid hormone progesterone in the mid-postovulatory phase of the menstrual cycle is frequently used to determine ovulation. The aim of this study was to investigate whether increasing blood concentrations of progesterone in the mid-postovulatory phase was associated with higher chances of achieving a live birth in a group of 335 women with anovulatory infertility, who had undergone stimulation with gonadotrophin hormones for the purpose of inducing ovulation. Statistical analysis, performed on the 279 women with presumptive ovulation (defined as a mid-postovulatory progesterone concentration ⩾7.9ng/ml serum), showed that the mid-postovulatory progesterone concentration was significantly positively associated with live birth rate. There was also a significant association between follicular development at end of gonadotrophin stimulation and the mid-postovulatory progesterone concentration, but follicular development could not explain live birth rate as mid-postovulatory progesterone concentrations could. In conclusion, increased blood concentrations of progesterone in the mid-postovulatory phase of the menstrual cycle above the threshold values currently used for defining ovulation were associated with increased live birth rates in anovulatory women undergoing ovulation induction with gonadotrophin hormones. The mid-postovulatory progesterone concentration, apart from being a consequence of the quantity of follicular development, may therefore also reflect the quality of the ovarian follicles and eggs.
authors.affiliation: Ferring Pharmaceuticals A/S, Reproductive Health, Global Clinical and Non-Clinical R & D, Copenhagen, Denmark.
authors.forename: J-C
authors.initials: JC
authors.lastname: Arce
authors.affiliation: Leeds General Infirmary, Department of Obstetrics and Gynaecology, Leeds, UK.
authors.forename: A
authors.initials: A
authors.lastname: Balen
authors.affiliation: UZ Brussel, Centre for Reproductive Medicine, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Platteau
authors.affiliation: Ferring Pharmaceuticals A/S, Reproductive Health, Global Clinical and Non-Clinical R & D, Copenhagen, Denmark.
authors.forename: G
authors.initials: G
authors.lastname: Pettersson
authors.affiliation: The Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
authors.forename: A Nyboe
authors.initials: AN
authors.lastname: Andersen
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D050498:Live Birth; D008183:Luteal Phase / Q000097:blood*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D011374:Progesterone