title: Investigation of surface plasmon biosensing using gold nanoparticles enhanced ellipsometry.
abstract: We present a label-free, nondestructive and high sensitivity biosensor by using the phase information of a gold nanoparticles enhanced ellipsometry signal. The refractive index (RI) resolution from ellipsometric phase information is of the order of 1.6×10(-6) RI units. Furthermore, spectroscopic and dynamic measurements show substantial change in the phase signal when biomolecules are coated on gold nanoparticles. The detection limit of our proposed technique is up to ∼18 pM concentration of the target biomolecules.
authors.affiliation: Research Centre for Applied Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Rakesh Singh
authors.initials: RS
authors.lastname: Moirangthem
authors.forename: Yia-Chung
authors.initials: YC
authors.lastname: Chang
authors.forename: Pei-Kuen
authors.initials: PK
authors.lastname: Wei
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D002417:Cattle; D005898:Glass / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D055620:Optical Phenomena; D012710:Serum Albumin, Bovine / Q000276:immunology; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D000906:Antibodies; D012710:Serum Albumin, Bovine; D006046:Gold