title: [Effectiveness of adjuvant chemotherapy using gemcitabine for resected pancreatic cancer].
abstract: BACKGROUND
  The aim was to evaluate the adjuvant chemotherapy using gemcitabine (GEM) for resected pancreatic cancer.
  
  
  METHODS
  We investigated 69 patients who had undergone curative operations for pancreatic cancer. They were classified into two groups of patients using GEM (group A: 37) and patients with surgery alone (group B: 32) between 2009 and 1998. Outcomes, including disease-free survival (DFS), median survival time (MST), and adverse events were reported retrospectively. Patients assigned to the gemcitabine group received GEM at a dose of 800 mg/m² on days 1, 8 and 15, every 4 weeks for 5 cycles.
  
  
  RESULTS
  DFS and MST did not differ significantly between group A and group B (DFS; group A: 10. 4 vs group B 8. 0 months, MST; group A: 21. 7 vs group B 16. 3 months). The estimated overall survival rates at 3 and 5 years were 40% and 25. 7%, respectively, in group A, and 12. 9% and 12. 9% in group B. Grade 3 or 4 toxicity revealed 8.1%with leucopenia, 2. 7% with thrombocytopenia, and 2. 7% with nausea.
  
  
  RESULTS
  Adjuvant chemotherapy using gemcitabine for resected pancreatic cancer contributes to prolonged DFS, MST, and estimated overall survival.
authors.affiliation: Hachioji Digestive Disease Hospital, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Morishita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kaji
authors.forename: Nobusada
authors.initials: N
authors.lastname: Koike
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Harada
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Takeo
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Hayashi
authors.forename: Mamoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Fujio
authors.initials: F
authors.lastname: Hanyu
mesh_terms: D000368:Aged; D017024:Chemotherapy, Adjuvant; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D000093542:Gemcitabine