title: Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex.
authors.affiliation: Institut für Bioanalytische Chemie, Biotechnologisch-Biomedizinisches Zentrum, Fakultät für Chemie und Mineralogie, Universität Leipzig, Leipzig, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Knappe
authors.forename: Michael
authors.initials: M
authors.lastname: Zahn
authors.forename: Ute
authors.initials: U
authors.lastname: Sauer
authors.forename: Guido
authors.initials: G
authors.lastname: Schiffer
authors.forename: Norbert
authors.initials: N
authors.lastname: Sträter
authors.forename: Ralf
authors.initials: R
authors.lastname: Hoffmann
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000493:pharmacokinetics; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000493:pharmacokinetics; D001419:Bacteria / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites; D015195:Drug Design; D004355:Drug Stability; D006207:Half-Life; D051379:Mice; D018832:Molecular Chaperones / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001426:Bacterial Proteins; D018832:Molecular Chaperones; D011994:Recombinant Proteins; C551620:oncocin