title: [Oxidative stress and combined antioxidant energy correction in the treatment of periodontitis].
abstract: Experimental-clinical study with inclusion of 50 Wistar rats with modeled parodontitis and 71 patients with chronic generalized parodontitis of different severity degree was conducted. Significance of oxidation stress in disease development and running was established in the course of the study. Disbalance of free-radical processes (FRP) in case of periodontal diseases affects oxygen stage of the oxidation stress in bigger degree and continues for a long time. In the course of experiment positive influence of cytoflavine preparation as energy-correction and antioxidant was confirmed as well as its combination with calcium-D3. In the course of comprehensive clinical study the efficacy of cytoflavine use was verified by the example of FRP correction that was accompanied by clinical picture and treatment results improvement.
authors.forename: I A
authors.initials: IA
authors.lastname: Omarov
authors.forename: S B
authors.initials: SB
authors.lastname: Bolevich
authors.forename: T N
authors.initials: TN
authors.lastname: Savateeva-Liubimova
authors.forename: E V
authors.initials: EV
authors.lastname: Silina
authors.forename: K V
authors.initials: KV
authors.lastname: Sivak
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002118:Calcium / Q000627:therapeutic use*; D002762:Cholecalciferol / Q000627:therapeutic use*; D002908:Chronic Disease; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005486:Flavin Mononucleotide / Q000627:therapeutic use*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects*; D010518:Periodontitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D005609:Free Radicals; D013386:Succinates; C507879:cytoflavin; D002762:Cholecalciferol; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D002118:Calcium