title: Synthesis, characterization and structures of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives and their probable glutathione peroxidase (GPx) like activity.
abstract: A series of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives has been synthesized. The glutathione peroxidase like catalytic activity of these compounds has been studied in a model system, in which reduction of hydrogen peroxide with dithiothreitol (DTT(red)), in the presence of an organoselenium compound was investigated by (1)H NMR spectroscopy. All these compounds exhibit GPx like catalytic activities and the catalytic reaction proceeds through a selenoxide intermediate, identified by (77)Se{(1)H} NMR spectroscopy.
authors.affiliation: Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India.
authors.forename: Ananda S
authors.initials: AS
authors.lastname: Hodage
authors.forename: Prasad P
authors.initials: PP
authors.lastname: Phadnis
authors.forename: Amey
authors.initials: A
authors.lastname: Wadawale
authors.forename: K I
authors.initials: KI
authors.lastname: Priyadarsini
authors.forename: Vimal K
authors.initials: VK
authors.lastname: Jain
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis*; D002384:Catalysis; D005979:Glutathione Peroxidase / Q000378:metabolism*; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D018036:Selenium Compounds / Q000138:chemical synthesis*
chemical_list: D011720:Pyrazoles; D018036:Selenium Compounds; D005979:Glutathione Peroxidase