title: Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population.
abstract: Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD (P = 5.00 × 10⁻³, stage 2 validation; P = 3.00 × 10⁻³, P = 1.19 × 10⁻⁸ and P = 4.00 × 10⁻³ in three independent stage 3 replication populations; P = 4.87 × 10⁻¹², odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population.
authors.affiliation: Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Cheng-Qi
authors.initials: CQ
authors.lastname: Xu
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Cai
authors.forename: Xiu-Chun
authors.initials: XC
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Xiong
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Liao
authors.forename: Qiu-Tang
authors.initials: QT
authors.lastname: Zeng
authors.forename: Yan-Zong
authors.initials: YZ
authors.lastname: Yang
authors.forename: Xiang
authors.initials: X
authors.lastname: Cheng
authors.forename: Cong
authors.initials: C
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.forename: Chu-Chu
authors.initials: CC
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Qiu-Lun
authors.initials: QL
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Bai
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Huang
authors.forename: Dan
authors.initials: D
authors.lastname: Yin
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Dai
authors.forename: Rong-Feng
authors.initials: RF
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Wan
authors.forename: Jiang-Hua
authors.initials: JH
authors.lastname: Ren
authors.forename: Si-Si
authors.initials: SS
authors.lastname: Li
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Zhao
authors.forename: Fen-Fen
authors.initials: FF
authors.lastname: Fu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Qing-Xian
authors.initials: QX
authors.lastname: Li
authors.forename: Sheng-Wei
authors.initials: SW
authors.lastname: Shi
authors.forename: Nan
authors.initials: N
authors.lastname: Lin
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Pan
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Wu
authors.forename: Yu-He
authors.initials: YH
authors.lastname: Ke
authors.forename: Jian
authors.initials: J
authors.lastname: Lei
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Luo
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Ji
authors.forename: Lian-Jun
authors.initials: LJ
authors.lastname: Gao
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Er-Wen
authors.initials: EW
authors.lastname: Huang
authors.forename: Jin
authors.initials: J
authors.lastname: Cui
authors.forename: Na
authors.initials: N
authors.lastname: Jia
authors.forename: Xiang
authors.initials: X
authors.lastname: Ren
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Tie
authors.initials: T
authors.lastname: Ke
authors.forename: Xian-Qin
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Liu
authors.forename: Mu-Gen
authors.initials: MG
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Xia
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Li-Song
authors.initials: LS
authors.lastname: Shi
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Xia
authors.forename: Xin
authors.initials: X
authors.lastname: Tu
authors.forename: Qing K
authors.initials: QK
authors.lastname: Wang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000235:genetics; D012307:Risk Factors
chemical_list: D012333:RNA, Messenger