title: The role of optimal control in assessing the most cost-effective implementation of a vaccination programme: HPV as a case study.
abstract: Vaccination against the human papillomavirus (HPV) is a recent development in the UK. This paper uses an optimal control model to explore how best to target vaccination. We find that the vaccination of sexually active individuals has a greater impact on disease control than the vaccination of sexually non-active individuals. Extending the model to include male vaccination, we find that including males in a vaccination strategy is cost-effective. We compare the optimal control solution to that from a constant control model and show that the optimal control model is more efficient at forcing the system to a disease-controlled steady state.
authors.affiliation: Centre for Mathematical Biology, University of Bath, Bath BA2 7AY, UK. vlbrown@umich.edu
authors.forename: V L
authors.initials: VL
authors.lastname: Brown
authors.forename: K A
authors.initials: KA
authors.lastname: Jane White
mesh_terms: D000293:Adolescent; D002648:Child; D003362:Cost-Benefit Analysis / Q000191:economics; D005260:Female; D006801:Humans; D008297:Male; D018803:Models, Economic; D009716:Numerical Analysis, Computer-Assisted; D027383:Papillomaviridae / Q000276:immunology*; D030361:Papillomavirus Infections / Q000191:economics / Q000517:prevention & control* / Q000821:virology; D053918:Papillomavirus Vaccines / Q000008:administration & dosage* / Q000191:economics* / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000191:economics / Q000517:prevention & control / Q000821:virology*; D014611:Vaccination / Q000191:economics
chemical_list: D053918:Papillomavirus Vaccines