title: [Determination of the migration of bisphenol diglycidyl ethers from food contact materials by high performance chromatography-tandem mass spectrometry coupled with multi-walled carbon nanotubes solid phase extraction].
abstract: A comprehensive analytical method based on high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed for measuring 6 exogenous endocrine disruptors--bisphenol diglycidyl ethers, including bisphenol A diglycidyl ether (BADGE), bisphenol A glycidyl (2,3-dihydroxypropyl) ether (BADGE x H2O), bisphenol A glycidyl (3-chloro-2-hydroxypropyl) ether ( BADGE x HCl), bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether (BADGE x H2O x HCl), bisphenol F diglycidyl ether (BFDGE) and bisphenol F bis (3-chloro-2-hydroxypropyl) ether (BFDGE x 2HCl). The samples were extracted with methyl tert-butyl ether (MTBE) by ultrasonic wave assistant extraction. The extracts were cleaned up and concentrated on multi-walled carbon nanotubes (MWCNTs). The target compounds were analyzed by HPLC-MS/MS under positive ion mode using a COSMOSIL C18 column as analytical column. Under the optimal conditions, the calibration curves showed a good linearity in the concentration range of 1.0-100.0 microg/L for 6 target compounds. The correlation coefficients (r2) were higher than 0.999 1. Recoveries of 6 analytes at three spiked levels ranged from 78.6% to 89.9%, with relative standard deviations (RSDs) less than 10%. The detection limits of the method ranged from 0.5 to 1.5 microg/L. The method is sensitive and simple, and is suitable for the rapid determination of the migration of bisphenol diglycidyl ethers from food contact materials.
authors.affiliation: Hunan Academy of Inspection and Quarantine, Technology Center of Hunan Entry-Exit Inspection and Quarantine Bureau, Hunan Key Laboratory of Food Safety Science & Technology, Changsha 410004, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.forename: Zhonghai
authors.initials: Z
authors.lastname: Li
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Liu
authors.forename: Libing
authors.initials: L
authors.lastname: Wang
mesh_terms: D001559:Benzhydryl Compounds; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004852:Epoxy Compounds / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D018857:Food Packaging; D006801:Humans; D037742:Nanotubes, Carbon; D052616:Solid Phase Extraction / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004852:Epoxy Compounds; D037742:Nanotubes, Carbon; C019273:bisphenol A diglycidyl ether; D000098826:Bisphenol A Compounds