title: Determination of ciclopirox olamine in pharmaceutical products by capillary electrophoresis with capacitively coupled contactless conductivity detection.
abstract: This paper describes the determination of ciclopirox olamine in pharmaceutical formulations using capillary electrophoresis with capacitively coupled contactless conductivity detection. In an alkaline medium, ciclopirox olamine is converted into an anionic species and its detection is possible in capillary electrophoresis with capacitively coupled contactless conductivity detection without an electroosmotic flow modifier, because it is a low-mobility species. A linear working range from 2.64 to 264 μg/mL in sodium hydroxide electrolyte as well as low detection limit (0.39 μg/mL) and a good repeatability (RSD = 3.4% for 264 μg/mL ciclopirox solution (n = 10)) were achieved. It was also possible to determine olamine in its cationic form when acetic acid was used as the electrolyte solution. The results obtained include a linear range from 26.4 to 184.8 μg/mL and a detection limit of 2.6 μg/mL olamine. The proposed methods were applied to the analysis of commercial pharmaceutical products and the results were compared with the values indicated by the manufacturer as well as those obtained using a titrimetric method recommended by American Pharmacopoeia.
authors.affiliation: Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Fabiana Silva
authors.initials: FS
authors.lastname: Felix
authors.forename: Claudimir Lucio
authors.initials: CL
authors.lastname: do Lago
authors.forename: Lúcio
authors.initials: L
authors.lastname: Angnes
mesh_terms: D000935:Antifungal Agents / Q000032:analysis*; D000077768:Ciclopirox; D004553:Electric Conductivity; D019075:Electrophoresis, Capillary / Q000379:methods*; D016014:Linear Models; D009824:Ointments / Q000737:chemistry; D019999:Pharmaceutical Solutions / Q000737:chemistry; D011728:Pyridones / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000935:Antifungal Agents; D009824:Ointments; D019999:Pharmaceutical Solutions; D011728:Pyridones; D000077768:Ciclopirox