title: Implications from addiction research towards the understanding and treatment of obesity.
abstract: Recent research indicates similarities between obesity and addictive disorders on both the phenomenological and neurobiological level. In particular, neuroendocrine and imaging studies suggest a close link between the homeostatic regulation of appetite on the on hand, and motivation and reward expectancy on the other. In addition, findings from neuropsychological studies additionally demonstrate alterations of cognitive function in both obesity and addictive disorders that possibly contribute to a lack of control in resisting consumption. In this review, recent findings on overlapping neurobiological and phenomenological pathways are summarized and the impact with regard to new treatment approaches for obesity is discussed.
authors.affiliation: Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Grosshans
authors.forename: Sabine
authors.initials: S
authors.lastname: Loeber
authors.forename: Falk
authors.initials: F
authors.lastname: Kiefer
mesh_terms: D000818:Animals; D001066:Appetite / Q000502:physiology; D001521:Behavior Therapy; D001921:Brain / Q000503:physiopathology*; D003072:Cognition Disorders / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation; D015928:Cognitive Behavioral Therapy; D003213:Conditioning, Psychological / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D055317:Evidence-Based Practice; D020022:Genetic Predisposition to Disease / Q000235:genetics; D054439:Ghrelin / Q000097:blood; D006801:Humans; D006815:Hunger / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood; D020738:Leptin / Q000097:blood; D009042:Motivation / Q000502:physiology; D009479:Neuropeptides / Q000097:blood; D009765:Obesity / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology* / Q000534:rehabilitation; D000068797:Orexins; D017397:Prefrontal Cortex / Q000503:physiopathology; D017448:Receptors, Dopamine D2 / Q000502:physiology; D012657:Self-Help Groups; D019966:Substance-Related Disorders / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology* / Q000534:rehabilitation
chemical_list: D054439:Ghrelin; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin; D009479:Neuropeptides; D000068797:Orexins; D017448:Receptors, Dopamine D2