title: Partially polymerized liposomes: stable against leakage yet capable of instantaneous release for remote controlled drug delivery.
abstract: A critical issue for current liposomal carriers in clinical applications is their leakage of the encapsulated drugs that are cytotoxic to non-target tissues. We have developed partially polymerized liposomes composed of polydiacetylene lipids and saturated lipids. Cross-linking of the diacetylene lipids prevents the drug leakage even at 40 °C for days. These inactivated drug carriers are non-cytotoxic. Significantly, more than 70% of the encapsulated drug can be instantaneously released by a laser that matches the plasmon resonance of the tethered gold nanoparticles on the liposomes, and the therapeutic effect was observed in cancer cells. The remote activation feature of this novel drug delivery system allows for precise temporal and spatial control of drug release.
authors.affiliation: Department of Radiology, The Methodist Hospital Research Institute, Houston, TX 77030, USA.
authors.forename: Guoting
authors.initials: G
authors.lastname: Qin
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Rongmin
authors.initials: R
authors.lastname: Xia
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Brian E
authors.initials: BE
authors.lastname: O'Neill
authors.forename: Jessica T
authors.initials: JT
authors.lastname: Goodwin
authors.forename: Htet A
authors.initials: HA
authors.lastname: Khant
authors.forename: Wah
authors.initials: W
authors.lastname: Chiu
authors.forename: King C
authors.initials: KC
authors.lastname: Li
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D000814:Aniline Compounds; D001682:Biological Availability; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D020285:Cryoelectron Microscopy; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D053280:Diynes / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology; D004355:Drug Stability; D004705:Endocytosis; D005260:Female; D005452:Fluoresceins / Q000008:administration & dosage / Q000493:pharmacokinetics; D005998:Glycine; D006046:Gold / Q000737:chemistry; D006801:Humans; D007098:Imino Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D007834:Lasers; D008081:Liposomes / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D008246:Lysophospholipids / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D015609:Organotechnetium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D020349:Surface Plasmon Resonance
chemical_list: D000814:Aniline Compounds; D003692:Delayed-Action Preparations; D053280:Diynes; D005452:Fluoresceins; D007098:Imino Acids; D008081:Liposomes; D008246:Lysophospholipids; D015609:Organotechnetium Compounds; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D011108:Polymers; D015060:1,2-Dipalmitoylphosphatidylcholine; D006046:Gold; C053923:1,2-bis(10,12-tricosadiynoyl)phosphatidylcholine; D004317:Doxorubicin; C034837:technetium Tc 99m mebrofenin; D005998:Glycine; C007740:fluorexon