title: Paraoxonase and arylesterase activities in stent restenosis in bare metal stent.
abstract: OBJECTIVE
  The serum paraoxonase and arylesterase activities are related to coronary artery diseases. However, there are a few data about the association of paraoxonase and arylesterase activities with in-stent restenosis (ISR). The aim of this study was to evaluate the relationship between paraoxonase and arylesterase activities and ISR in patients with bare metal stent (BMS).
  
  
  METHODS
  Thirty-one patients with normal coronary artery (group 1) and 60 with BMS were enrolled in this observational study. According to the ISR, the patients were classified as group 2, without the ISR (n=29) and group 3, with the ISR (n=31). Serum paraoxonase and arylesterase activities were measured spectrophotometrically.
  
  
  RESULTS
  The paraoxonase and arylesterase activities were lower in patients with BMS than in the individuals with normal coronary artery (P < 0.001 and P = 0.001, respectively). The enzyme activities were also higher in patients without ISR than with ISR (both of P < 0.001). In bivariate correlation analyses in patients with BMS, ISR shows significant positive correlations with the presence of hypertension and hyperlipidemia, type C lesion, and stent length, but shows negative correlations with type A lesion stent diameter, high-density lipoprotein cholesterol, and paraoxonase and arylesterase activities. In regression analysis, ISR is independently associated with paraoxonase and arylesterase activities (β = -0.216, P = 0.038 and β = -0.452, P < 0.001, respectively), type A lesion (β = -0.251, P = 0.013), and stent diameter (β = -0.192, P = 0.024) in patients with BMS.
  
  
  CONCLUSIONS
  Our study shows that decreased paraoxonase and arylesterase activities play a significant role in ethiopathogenesis ISR in patients with BMS.
authors.affiliation: Department of Cardiology, Medical Faculty of Harran University, Sanliurfa, Turkey. rdemirbag@yahoo.com
authors.forename: Recep
authors.initials: R
authors.lastname: Demirbag
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Sezen
authors.forename: Asuman Biçer
authors.initials: AB
authors.lastname: Yeşilay
authors.forename: Memduh
authors.initials: M
authors.lastname: Bas
authors.forename: Ali
authors.initials: A
authors.lastname: Yildiz
authors.forename: Unal
authors.initials: U
authors.lastname: Guntekin
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000201:enzymology*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008670:Metals; D008875:Middle Aged; D015607:Stents
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008670:Metals; D003404:Creatinine; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase