title: A novel respiratory model of infection with monkeypox virus in cynomolgus macaques.
abstract: Variola, the causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposefully released, would cause public panic and social disruption. For this reason research continues in the areas of animal model and therapeutic development. Orthopoxviruses show a widely varying degree of host specificity, making development of accurate animal models difficult. In this paper, we demonstrate a novel respiratory infection technique that resulted in "classic" orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model.
authors.affiliation: United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Virology Division, Viral Therapeutics Branch, 903Q, Fort Detrick, MD 21702-5011, USA. Arthur.Goff@amedd.army.mil
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Goff
authors.forename: Jennifer
authors.initials: J
authors.lastname: Chapman
authors.forename: Chad
authors.initials: C
authors.lastname: Foster
authors.forename: Carly
authors.initials: C
authors.lastname: Wlazlowski
authors.forename: Joshua
authors.initials: J
authors.lastname: Shamblin
authors.forename: Kenny
authors.initials: K
authors.lastname: Lin
authors.forename: Norman
authors.initials: N
authors.lastname: Kreiselmeier
authors.forename: Eric
authors.initials: E
authors.lastname: Mucker
authors.forename: Jason
authors.initials: J
authors.lastname: Paragas
authors.forename: James
authors.initials: J
authors.lastname: Lawler
authors.forename: Lisa
authors.initials: L
authors.lastname: Hensley
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008252:Macaca fascicularis; D045908:Mpox, Monkeypox / Q000473:pathology* / Q000821:virology*; D008993:Monkeypox virus / Q000472:pathogenicity*; D012141:Respiratory Tract Infections / Q000473:pathology* / Q000821:virology*