title: Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning.
abstract: OBJECTIVE
  To report clinical features and treatment of 16 cases of acute 2,4-dinitrophenol poisoning.
  
  
  METHODS
  A total of 16 patients suffering from acute poisoning due to non-oral exposure to 2,4-dinitrophenol were sent to our hospital. Two died within 3 h after admission, while the other 14 responded to supportive treatment and hemoperfusion. Clinical features and treatment of the patients were retrospectively analyzed and presented.
  
  
  RESULTS
  Fourteen patients recovered and were discharged after four to six weeks of treatment. No obvious poisoning sequelae were found in the three-month follow-up.
  
  
  CONCLUSIONS
  Non-oral exposure to 2,4-dinitrophenol is toxic. Hemoperfusion and glucocorticoid treatments may be efficient measures to prevent mortality, but this requires further study.
authors.affiliation: Department of Emergency, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China. luyuanqiang@yahoo.cn
authors.forename: Yuan-qiang
authors.initials: YQ
authors.lastname: Lu
authors.forename: Jiu-kun
authors.initials: JK
authors.lastname: Jiang
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Huang
mesh_terms: D019297:2,4-Dinitrophenol / Q000506:poisoning*; D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010477:Perfusion; D011041:Poisoning / Q000401:mortality; D012137:Respiratory System / Q000187:drug effects; D012189:Retrospective Studies; D012867:Skin / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D019297:2,4-Dinitrophenol