title: Reversible posterior leukoencephalopathy induced by carboplatin and etoposide.
abstract: Reversible posterior leukoencephalopathy syndrome (RPLS) is a rare neurologic condition characterised by specific clinical and radiologic findings. It usually manifests subacutely as insidious onset of headache, visual disturbance, altered consciousness and seizures in association with MRI findings of posterior white matter vasogenic oedema. RPLS has been reported in a wide variety of clinical settings. Hypertension, eclampsia, pre-eclampsia, renal impairment, autoimmune conditions and cytotoxic drugs are all cited as aetiologic variables. RPLS, albeit rare, is an important entity for physicians to be aware of as early recognition, and prompt intervention is critical to ensure resolution of the neurological deficit. We describe the case of a 69-year-old lady who collapsed with seizure activity after receiving carboplatin and etoposide chemotherapy for small cell lung cancer. In our opinion, the clinical and radiological courses are typical of RPLS. RPLS has rarely been reported secondary to this chemotherapy regimen, and the purpose of this report is to add to the literature and highlight the association between RPLS and cytotoxic chemotherapy.
authors.affiliation: Department of Medical Oncology, Mercy/Cork University Hospitals, Grenville Place, Cork, Ireland.
authors.forename: S A
authors.initials: SA
authors.lastname: Ryan
authors.forename: P
authors.initials: P
authors.lastname: Maceneaney
authors.forename: S P
authors.initials: SP
authors.lastname: O'Reilly
authors.forename: E J
authors.initials: EJ
authors.lastname: Moylan
authors.forename: D G
authors.initials: DG
authors.lastname: Power
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D016190:Carboplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D011379:Prognosis; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy*
chemical_list: D005047:Etoposide; D016190:Carboplatin