title: Antifungal activity and mechanism of fengycin in the presence and absence of commercial surfactin against Rhizopus stolonifer.
abstract: The antifungal activity and mechanism of fengycin in the presence and absence of commercial surfactin against Rhizopus stolonifer were investigated. The MIC (minimal inhibitory concentration) of fengycin without commercial surfactin added was 0.4 mg/ml while the MIC of fengycin with commercial surfactin added was 2.0 mg/ml. Fengycin acted on cell membrane and cellular organs and inhibited DNA synthesis. The antifungal effect of fengycin was reduced after commercial surfactin was added. All these results suggest that the fungal cell membrane may be the primary target of fengycin action and commercial surfactin may reduce the antifungal activity of fengycin.
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University, Weigang, Nanjing, 210095, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Tao
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Bie
authors.forename: Feng-xia
authors.initials: FX
authors.lastname: Lv
authors.forename: Hai-zhen
authors.initials: HZ
authors.lastname: Zhao
authors.forename: Zhao-xin
authors.initials: ZX
authors.lastname: Lu
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D053898:Biosynthetic Pathways / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D004347:Drug Interactions; D055666:Lipopeptides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015388:Organelles / Q000187:drug effects; D010456:Peptides, Cyclic / Q000494:pharmacology*; D012233:Rhizopus / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D055666:Lipopeptides; D010456:Peptides, Cyclic; C049972:fengycin; C009365:surfactin peptide; D004247:DNA