title: Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression.
abstract: The predominant role of matrix metalloproteinase 8 in extracellular matrix turnover, modulation of inflammatory responses and other physiological processes is well documented. Several recent studies highlight the involvement of MMP8 in a wide range of pathologies. This review will shed light on the putative role of MMP8 as a drug target or disease marker in some inflammatory disorders and in cancer progression.
authors.affiliation: Department for Molecular Biomedical Research, VIB, Ghent, Belgium.
authors.forename: Eline
authors.initials: E
authors.lastname: Dejonckheere
authors.forename: Roosmarijn E
authors.initials: RE
authors.lastname: Vandenbroucke
authors.forename: Claude
authors.initials: C
authors.lastname: Libert
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000503:physiopathology; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000503:physiopathology; D018450:Disease Progression; D005109:Extracellular Matrix / Q000502:physiology; D005128:Eye Diseases / Q000503:physiopathology; D005767:Gastrointestinal Diseases / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008107:Liver Diseases / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000503:physiopathology; D008288:Malaria / Q000503:physiopathology; D020784:Matrix Metalloproteinase 8 / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology*; D009422:Nervous System Diseases / Q000503:physiopathology; D010510:Periodontal Diseases / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D020784:Matrix Metalloproteinase 8