title: Synthesis of novel functional polycyclic chromones through Michael addition and double cyclizations.
abstract: A base-promoted, microwave-assisted one-pot tandem reaction from simple 3-(1-alkynyl)chromones with 2-halobenzylic nitriles (esters or amides) for the synthesis of novel functional polycyclic chromenones has been developed. This tandem process involves multiple reactions, such as Michael addition and double cyclizations without a transition metal catalyst.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, 555 Zu Chong Zhi Road, Shanghai, 201203, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Liping
authors.initials: L
authors.lastname: Huang
authors.forename: Fuchun
authors.initials: F
authors.lastname: Xie
authors.forename: Xuxing
authors.initials: X
authors.lastname: Chen
authors.forename: Youhong
authors.initials: Y
authors.lastname: Hu
mesh_terms: D002867:Chromones / Q000138:chemical synthesis*; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D002867:Chromones