title: Type and location of interaction between hyperbranched polymers and liposomes. Relevance to design of a potentially advanced drug delivery nanosystem (aDDnS).
abstract: Advanced drug delivery nanosystems (aDDnSs) combining liposomal and dendritic materials have only recently appeared in the research field of drug delivery. The nature and localization of the interactions between the components of such systems are not yet fully described. In this study, liposomes are combined with hyperbranched polyesters for the development of new aDDnSs. The polymer-lipid interactions along with their dependence on the polyesters pseudogeneration number and the liposomal lipid composition have been examined. The results indicate that the interaction between the materials takes place in the headgroup region, where H-bonds between the polymers terminal hydroxyls and the phospholipids phosphate moiety are formed. Due to the polymers' compact imperfect structure, which varies with pseudogeneration number, no linear trends are observed with increasing pseudogeneration number. Moreover, it is shown that high percentages of cholesterol in the lipid bilayer affect the penetration of the polymers in the headgroup region.
authors.affiliation: Department of Pharmaceutical Technology, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
authors.forename: Elena A
authors.initials: EA
authors.lastname: Mourelatou
authors.forename: Dima
authors.initials: D
authors.lastname: Libster
authors.forename: Ido
authors.initials: I
authors.lastname: Nir
authors.forename: Sophia
authors.initials: S
authors.lastname: Hatziantoniou
authors.forename: Abraham
authors.initials: A
authors.lastname: Aserin
authors.forename: Nissim
authors.initials: N
authors.lastname: Garti
authors.forename: Costas
authors.initials: C
authors.lastname: Demetzos
mesh_terms: D006860:Hydrogen Bonding; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D036103:Nanotechnology; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D008051:Lipid Bilayers; D008081:Liposomes; D011091:Polyesters; D011108:Polymers