title: Bio-Repository of DNA in stroke (BRAINS): a study protocol.
abstract: BACKGROUND
  Stroke is one of the commonest causes of mortality in the world and anticipated to be an increasing burden to the developing world. Stroke has a genetic basis and identifying those genes may not only help us define the mechanisms that cause stroke but also identify novel therapeutic targets. However, large scale highly phenotyped DNA repositories are required in order for this to be achieved.
  
  
  METHODS
  The proposed Bio-Repository of DNA in Stroke (BRAINS) will recruit all subtypes of stroke as well as controls from two different continents, Europe and Asia. Subjects recruited from the UK will include stroke patients of European ancestry as well as British South Asians. Stroke subjects from South Asia will be recruited from India and Sri Lanka. South Asian cases will also have control subjects recruited.
  
  
  CONCLUSIONS
  We describe a study protocol to establish a large and highly characterized stroke biobank in those of European and South Asian descent. With different ethnic populations being recruited, BRAINS has the ability to compare and contrast genetic risk factors between those of differing ancestral descent as well as those who migrate into different environments.
authors.affiliation: Imperial College Cerebrovascular Research Unit (ICCRU), Imperial College London, UK.
authors.forename: Sunaina
authors.initials: S
authors.lastname: Yadav
authors.forename: Renata
authors.initials: R
authors.lastname: Schanz
authors.forename: Ankita
authors.initials: A
authors.lastname: Maheshwari
authors.forename: Muhammad Saleem
authors.initials: MS
authors.lastname: Khan
authors.forename: Julia
authors.initials: J
authors.lastname: Slark
authors.forename: Ranil
authors.initials: R
authors.lastname: de Silva
authors.forename: Paul
authors.initials: P
authors.lastname: Bentley
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
authors.forename: Jaspal
authors.initials: J
authors.lastname: Kooner
authors.forename: Padma
authors.initials: P
authors.lastname: Shrivastav
authors.forename: Kameshwar
authors.initials: K
authors.lastname: Prasad
authors.forename: Pankaj
authors.initials: P
authors.lastname: Sharma
mesh_terms: D018070:Biological Specimen Banks; D004247:DNA / Q000737:chemistry; D055106:Genome-Wide Association Study; D006801:Humans; D010641:Phenotype; D012307:Risk Factors; D020521:Stroke / Q000208:ethnology / Q000235:genetics*
chemical_list: D004247:DNA