title: A curated database of miRNA mediated feed-forward loops involving MYC as master regulator.
abstract: BACKGROUND
  The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level.
  
  
  RESULTS
  Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF.
  
  
  CONCLUSIONS
  We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.
authors.affiliation: Department of Theoretical Physics, University of Turin and National Institute for Nuclear Physics, Turin, Italy.
authors.forename: Mariama
authors.initials: M
authors.lastname: El Baroudi
authors.forename: Davide
authors.initials: D
authors.lastname: Corà
authors.forename: Carla
authors.initials: C
authors.lastname: Bosia
authors.forename: Matteo
authors.initials: M
authors.lastname: Osella
authors.forename: Michele
authors.initials: M
authors.lastname: Caselle
mesh_terms: D019295:Computational Biology; D030541:Databases, Genetic; D025461:Feedback, Physiological; D053263:Gene Regulatory Networks / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D058977:Molecular Sequence Annotation; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D015203:Reproducibility of Results
chemical_list: D035683:MicroRNAs; D016271:Proto-Oncogene Proteins c-myc