title: Physiology and pathology of endosome-to-Golgi retrograde sorting.
abstract: Bidirectional traffic between the Golgi apparatus and the endosomal system sustains the functions of the trans-Golgi network (TGN) in secretion and organelle biogenesis. Export of cargo from the TGN via anterograde trafficking pathways depletes the organelle of sorting receptors, processing proteases, SNARE molecules, and other factors, and these are subsequently retrieved from endosomes via the retrograde pathway. Recent studies indicate that retrograde trafficking is vital to early metazoan development, nutrient homeostasis, and for processes that protect against Alzheimer's and other neurological diseases.
authors.affiliation: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6058, USA. cburd@mail.med.upenn.edu
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Burd
mesh_terms: D000818:Animals; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism / Q000473:pathology* / Q000502:physiology*; D006801:Humans; D021381:Protein Transport; D015398:Signal Transduction; D021601:trans-Golgi Network / Q000378:metabolism / Q000473:pathology* / Q000502:physiology*
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport