title: Serum adiponectin and leptin as predictors of the presence and degree of coronary atherosclerosis.
abstract: BACKGROUND
  The association of adipocyte-derived proteins, adiponectin and leptin, with the degree of coronary atherosclerosis has not been not been well elucidated. This study aimed to determine the relationship between serum adiponectin and leptin with the presence and degree of coronary atherosclerosis.
  
  
  METHODS
  Seventy patients and 20 matched controls were recruited. Angiographic evaluation of coronary atherosclerosis was carried out by assessing three atherosclerotic indices, severity (transverse disease), extent (longitudinal disease), and pattern (lesion complexity).
  
  
  RESULTS
  The independent predictors of atherosclerosis severity were larger waist/hip ratio, followed by higher low-density lipoprotein-cholesterol, low serum adiponectin level, older age, higher leptin level, current unstable angina, and finally previous myocardial infarction (MI). This model is a good one as indicated by the model-adjusted r (50%). For extent index, lower serum adiponectin level was by far the most important independent predictor, followed by higher low-density lipoprotein-cholesterol, older age, and previous MI, whereas higher serum leptin level was only a univariate predictor. The model-adjusted r was 65%. For pattern index, the independent predictors were previous MI, lower serum adiponectin level, larger waist/hip ratio, higher serum leptin level, older age, and higher fasting blood glucose level. The model-adjusted r was 62%.
  
  
  CONCLUSIONS
  Both serum adiponectin and leptin might play an important pathogenic role not only in the occurrence but also in the severity, extent, and lesion complexity in coronary artery disease patients.
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt. hosam_hasan@hotmail.com
authors.forename: Hosam
authors.initials: H
authors.lastname: Hasan-Ali
authors.forename: Nashwa A
authors.initials: NA
authors.lastname: Abd El-Mottaleb
authors.forename: Hosny B
authors.initials: HB
authors.lastname: Hamed
authors.forename: Alaa
authors.initials: A
authors.lastname: Abd-Elsayed
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012720:Severity of Illness Index
chemical_list: D052242:Adiponectin; D020738:Leptin