title: No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.
abstract: Recent genome-wide association (GWA) studies have identified two intergenic single nucleotide polymorphisms (SNPs) (rs11833579 and rs12425791) on chromosome 12p13 and within 11 kb of the NINJ2 gene that were significantly associated with stroke in Caucasians. However, the validity of the association has remained controversial. We performed genetic association analyses in three independent cohorts, including total of 3042 cases and 2973 controls. No significant association between these two SNPs and ischemic stroke was detected by meta-analysis after adjustment for cardiovascular risk factors under the additive model. Our data does not support that the common variants on 12p13 are major contributors of ischemic stroke in the Chinese Han population.
authors.affiliation: The Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Ding
authors.forename: Xin
authors.initials: X
authors.lastname: Tu
authors.forename: Yujun
authors.initials: Y
authors.lastname: Xu
authors.forename: Chenqi
authors.initials: C
authors.lastname: Xu
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.forename: Guanglin
authors.initials: G
authors.lastname: Cui
authors.forename: Xunna
authors.initials: X
authors.lastname: Bao
authors.forename: Rutai
authors.initials: R
authors.lastname: Hui
authors.forename: Qing K
authors.initials: QK
authors.lastname: Wang
authors.forename: Dao Wen
authors.initials: DW
authors.lastname: Wang
mesh_terms: D000483:Alleles; D002545:Brain Ischemia / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D002681:China; D015331:Cohort Studies; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000208:ethnology / Q000235:genetics*
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; C504206:NINJ2 protein, human