title: Maternal serum adiponectin at 11 to 13 weeks of gestation in the prediction of macrosomia.
abstract: OBJECTIVE
  To examine the potential role of maternal serum level of adiponectin in the first trimester of pregnancy in the prediction of neonatal macrosomia.
  
  
  METHODS
  Maternal serum adiponectin concentration was measured in a case-control study of singleton pregnancies at 11 to 13 weeks' gestation, which included 50 cases that subsequently delivered macrosomic neonates with birth weight above the 95th percentile for gestation at delivery and 300 controls who delivered appropriate for gestational age neonates. The median multiple of the median (MoM) serum adiponectin in the two outcome groups was compared and the bivariate Gaussian distributions were simulated in a screened population of 33 344 pregnancies to estimate the performance of screening for macrosomia by a combination of maternal characteristics and obstetric history with serum adiponectin.
  
  
  RESULTS
  In the macrosomic group the median serum adiponectin [0.82, interquartile range (IQR): 0.56-1.02 MoM] was significantly lower than in the non-macrosomic controls (1.02, IQR: 0.70-1.29 MoM; p = 0.001). The estimated detection rate of macrosomia, at fixed false positive rate of 10%, from maternal characteristics and obstetric history was 34.6% and this increased to 38.2% with the addition of serum adiponectin.
  
  
  CONCLUSIONS
  Maternal serum adiponectin at 11 to 13 weeks is a useful biomarker for early prediction of macrosomia.
authors.affiliation: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
authors.forename: Surabhi
authors.initials: S
authors.lastname: Nanda
authors.forename: Ranjit
authors.initials: R
authors.lastname: Akolekar
authors.forename: Rita
authors.initials: R
authors.lastname: Sarquis
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Mosconi
authors.forename: Kypros H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D005320:Fetal Macrosomia / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D010298:Parity; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First / Q000097:blood*; D011296:Prenatal Diagnosis / Q000379:methods*; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D052242:Adiponectin; D015415:Biomarkers