title: Effects of parenteral soybean oil lipid emulsion on the long-chain polyunsaturated fatty acid profile in very-low-birth-weight infants.
abstract: OBJECTIVE
  Conventional soybean lipid emulsions contain no docosahexaenoic acid (DHA) or arachidonic acid (AA). We investigated the relationship between blood DHA and AA status in 27 very-low-birth-weight (VLBW) infants with or without parenteral lipid emulsion.
  
  
  METHODS
  Sixteen infants received parenteral lipid emulsion, and 11 infants were control group. The fatty acid composition of the erythrocyte membrane was analysed at birth and at 2 weeks of age.
  
  
  RESULTS
  No significant difference in AA levels was observed in the lipid emulsion group between the two time points, whereas the AA levels at 2 weeks were significantly lower than at birth in the control group. The DHA levels in both groups at 2 weeks were significantly lower than at birth, but no group differences were observed at both time points.
  
  
  CONCLUSIONS
  The use of parenteral soybean oil lipid emulsions in VLBW infants in the postnatal period may prevent the decline in the AA level but does not appear to influence the DHA level.
authors.affiliation: Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan. hshoji@juntendo.ac.jp
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Shoji
authors.forename: Ken
authors.initials: K
authors.lastname: Hisata
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Suzuki
authors.forename: Naomi
authors.initials: N
authors.lastname: Yoshikawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Suganuma
authors.forename: Natsuki
authors.initials: N
authors.lastname: Ohkawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D016718:Arachidonic Acid / Q000097:blood*; D016022:Case-Control Studies; D004281:Docosahexaenoic Acids / Q000097:blood*; D005217:Fat Emulsions, Intravenous; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D008297:Male; D010288:Parenteral Nutrition; D012189:Retrospective Studies; D013024:Soybean Oil / Q000008:administration & dosage*
chemical_list: D005217:Fat Emulsions, Intravenous; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D013024:Soybean Oil