title: Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice.
abstract: Fragile X syndrome (FXS) is the most common inherited form of mental retardation and is caused by the lack of fragile X mental retardation protein (FMRP). In the brain, spine abnormalities have been reported in both patients with FXS and Fmr1 knockout mice. This altered spine morphology has been linked to disturbed synaptic transmission related to altered signaling in the excitatory metabotropic glutamate receptor 5 (mGluR5) pathway. We investigated hippocampal protrusion morphology in adult Fmr1 knockout mice. Our results show a hippocampal CA1-specific altered protrusion phenotype, which was absent in the CA3 region of the hippocampus. This suggests a subregion-specific function of FMRP in synaptic plasticity in the brain.
authors.affiliation: CBG-Department of Clinical Genetics, Erasmus MC, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
authors.forename: Josien
authors.initials: J
authors.lastname: Levenga
authors.forename: Femke M S
authors.initials: FM
authors.lastname: de Vrij
authors.forename: Ronald A M
authors.initials: RA
authors.lastname: Buijsen
authors.forename: Tracy
authors.initials: T
authors.lastname: Li
authors.forename: Ingeborg M
authors.initials: IM
authors.lastname: Nieuwenhuizen
authors.forename: Andreea
authors.initials: A
authors.lastname: Pop
authors.forename: Ben A
authors.initials: BA
authors.lastname: Oostra
authors.forename: Rob
authors.initials: R
authors.lastname: Willemsen
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology* / Q000378:metabolism; D056654:CA3 Region, Hippocampal / Q000166:cytology / Q000378:metabolism; D049229:Dendritic Spines / Q000145:classification* / Q000235:genetics; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017966:Pyramidal Cells / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; C497684:Fmr1 protein, mouse