title: High-fat diet offsets the long-lasting effects of running-wheel access on food intake and body weight in OLETF rats.
abstract: We have previously demonstrated that running-wheel access normalizes the food intake and body weight of Otsuka Long-Evens Tokushima Fatty (OLETF) rats. Following 6 wk of running-wheel access beginning at 8 wk of age, the body weight of OLETF rats remains reduced, demonstrating a lasting effect on their phenotype. In contrast, access to a high-fat diet exacerbates the hyperphagia and obesity of OLETF rats. To determine whether diet modulates the long-term effects of exercise, we examined the effects of high-fat diet on food intake and body weight in OLETF rats that had prior access to running wheels for 4 wk. We found that 4 wk of running exercise significantly decreased food intake and body weight of OLETF rats. Consistent with prior results, 4 wk of exercise also produced long-lasting effects on food intake and body weight in OLETF rats fed a regular chow. When running wheels were relocked, OLETF rats stabilized at lower levels of body weight than sedentary OLETF rats. However, access to a high-fat diet offset these effects. When OLETF rats were switched to a high-fat diet following wheel relocking, they significantly increased food intake and body weight, so that they reached levels similar to those of sedentary OLETF rats fed a high-fat diet. Gene expression determination of hypothalamic neuropeptides revealed changes that appeared to be appropriate responses to the effects of diet and running exercise. Together, these results demonstrate that high-fat diet modulates the long-lasting effects of exercise on food intake and body weight in OLETF rats.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Pei-Ting
authors.initials: PT
authors.lastname: Chao
authors.forename: Chantelle E
authors.initials: CE
authors.lastname: Terrillion
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Moran
authors.forename: Sheng
authors.initials: S
authors.lastname: Bi
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology; D054369:Agouti-Related Protein / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects* / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects* / Q000502:physiology*; D018149:Glucose Intolerance / Q000503:physiopathology; D007031:Hypothalamus / Q000378:metabolism; D020738:Leptin / Q000097:blood; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D051381:Rats; D020334:Rats, Inbred OLETF; D013997:Time Factors
chemical_list: C515197:AGRP protein, rat; D054369:Agouti-Related Protein; D004041:Dietary Fats; D020738:Leptin; D011333:Pro-Opiomelanocortin; D003346:Corticotropin-Releasing Hormone