title: Focal transient ischemia increases APP-BP1 expression in neural progenitor cells.
abstract: Amyloid precursor protein binding protein-1 (APP-BP1) binds to the carboxyl terminus of APP. In this study, we explored whether APP-BP1 expression is affected by focal transient cerebral ischemia induced by middle cerebral artery occlusion in Wistar rats. APP-BP1 expression was increased in the dentate gyrus of the hippocampus and in the subventricular zone of rats exposed to focal transient cerebral ischemia. In addition, APP-BP1 immunoreactivity overlapped with antidoublecortin and anti-5-bromo-2-deoxyuridine labeling. Focal transient cerebral ischemia has been reported earlier to induce neurogenesis in adult brains. The upregulation of APP-BP1 expression in neural progenitor cells after focal transient ischemia suggests that this protein contributes to the neurogenesis induced by transient ischemia and reperfusion.
authors.affiliation: Department of Pharmacology, Seoul National University Bundang Hospital, Seoul National University, College of Medicine, Sungnam, Seoul, Korea.
authors.forename: Yuyoung
authors.initials: Y
authors.lastname: Joo
authors.forename: Sang Hyung
authors.initials: SH
authors.lastname: Lee
authors.forename: Sungji
authors.initials: S
authors.lastname: Ha
authors.forename: Bo-Hyun
authors.initials: BH
authors.lastname: Hong
authors.forename: Joung-Hun
authors.initials: JH
authors.lastname: Kim
authors.forename: Yoo-Hun
authors.initials: YH
authors.lastname: Suh
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Kim
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis*; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D015870:Gene Expression; D020869:Gene Expression Profiling; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000235:genetics / Q000378:metabolism*; D018613:Microscopy, Confocal; D058953:Neural Stem Cells / Q000378:metabolism*; D055495:Neurogenesis / Q000235:genetics*; D051381:Rats; D017208:Rats, Wistar; D044764:Ubiquitin-Activating Enzymes
chemical_list: D016564:Amyloid beta-Protein Precursor; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; C561401:Nae1 protein, rat; D044764:Ubiquitin-Activating Enzymes