title: [Effect of Euonymus alatus on the blood glucose and hemorheology in the rat model of Type 2 diabetes mellitus with blood stagnation].
abstract: OBJECTIVE
  To explore the effect of Euonymus alatus on the blood glucose and hemorheology in rat model of Type 2 diabetes mellitus with blood stagnation (DMBS).
  
  
  METHODS
  High fat diet with streptozocin was used to establish the rat model of Type 2 diabetes mellitus, followed by the prednisolone and adrenaline muscle injection to obtain DMBS. DMBS rats were divided into a DMBS group (treated with saline gavage), an Euonymus alatus group (treated with Euonymus alatus gavage), and a glybenzoylamide group (treated with glybenzoylamide gavage).A blank group was treated with saline gavage. The experiment lasted 4 weeks, followed by the evaluation of rats' behavior, and detection of fasting blood glucose and hemorheology.
  
  
  RESULTS
  Compared with DMBS rats, the symptoms of polydipsia and diuresis in Euonymus alatus rats were improved, with increased body weight (P<0.05), better fur and mental state, increased resistance for being caught, and reduced tongue stagnation. Compared with DMBS group, though body weight increased, resistance for being caught decreased in the glybenzoylamide group with bad fur and mental state,and tongue stagnation. As to the fasting blood glucose, there was significant difference between the Euonymus alatus group and the DMBS group (P<0.05). As to the hemorheology, including whole blood viscosity (shear rates 1,5,50, and 100 s(-1)), plasma viscosity, and hematocrit, the Euonymus alatus rats had a better efficacy than DMBS rats and glybenzoylamide rats (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  Euonymus alatus can reduce the fasting blood glucose of DMBS and improve blood stagnation.
authors.affiliation: Editorial Office of Journal of Hunan University of Traditional Chinese Medicine, Changsha 410208, China.
authors.forename: Ludan
authors.initials: L
authors.lastname: Li
authors.forename: Mengzhou
authors.initials: M
authors.lastname: Xie
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Zhao
authors.forename: Junfeng
authors.initials: J
authors.lastname: He
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001809:Blood Viscosity / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D029756:Euonymus / Q000737:chemistry*; D018056:Hemorheology / Q000187:drug effects; D008297:Male; D008516:Medicine, Chinese Traditional; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal