title: Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants.
abstract: Gene knockdown by RNA interference (RNAi) in Caenorhabditis elegans is readily achieved by feeding bacteria expressing double-stranded RNA (dsRNA). Enhanced RNAi (Eri) mutants facilitate RNAi due to their hypersensitivity to dsRNA. Here, we compare eight Eri mutants for sensitivity to ingested dsRNA, targeting a variety of tissue-specific genes.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Jimmy J
authors.initials: JJ
authors.lastname: Zhuang
authors.forename: Craig P
authors.initials: CP
authors.lastname: Hunter
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D005820:Genetic Testing; D009154:Mutation / Q000235:genetics*; D009928:Organ Specificity / Q000235:genetics*; D010641:Phenotype; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000378:metabolism
chemical_list: D012330:RNA, Double-Stranded