title: Comparison of hypothesis- and a novel hybrid data/hypothesis-driven method of functional MR imaging analysis in patients with brain gliomas.
abstract: OBJECTIVE
  An alternative technique, which is less influenced by tumor- and patient-related factors, is required to overcome the limits of GLM analysis of fMRI data in patients. The aim of this study was to statistically assess differences in the identification of language regions and hemispheric lateralization of language function between controls and patients as estimated by both the GLM and a novel combined ICA-GLM procedure.
  
  
  METHODS
  We retrospectively evaluated 42 patients with pathologically confirmed brain gliomas of the left frontal and/or temporoparietal lobes and a control group of 14 age-matched healthy volunteers who underwent BOLD fMRI to lateralize language functions in the cerebral hemispheres. Data were processed by using a classic GLM and ICA-GLM.
  
  
  RESULTS
  ICA-GLM demonstrated a higher sensitivity in detecting language activation, specifically in the left TPJ of patients. There were no significant differences between the GLM and ICA-GLM in controls; however, statistically significant differences were observed by using ICA-GLM for the LI in patients. For the computation of the LI, ICA-GLM was less influenced by the chosen statistical threshold compared with the GLM.
  
  
  CONCLUSIONS
  We suggest the use of the ICA-GLM as a valid alternative to the classic GLM method for presurgical mapping in patients with brain tumors and to replicate the present results in a broader sample of patients.
authors.affiliation: Department of Neuroscience and Imaging, University "G. d'Annunzio" Chieti-Pescara, Italy. caulo@unich.it
authors.forename: M
authors.initials: M
authors.lastname: Caulo
authors.forename: R
authors.initials: R
authors.lastname: Esposito
authors.forename: D
authors.initials: D
authors.lastname: Mantini
authors.forename: C
authors.initials: C
authors.lastname: Briganti
authors.forename: C
authors.initials: C
authors.lastname: Sestieri
authors.forename: P A
authors.initials: PA
authors.lastname: Mattei
authors.forename: C
authors.initials: C
authors.lastname: Colosimo
authors.forename: G L
authors.initials: GL
authors.lastname: Romani
authors.forename: A
authors.initials: A
authors.lastname: Tartaro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D001037:Aphasia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D005910:Glioma / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult