title: Progress in mining the human proteome for disease applications.
abstract: Currently available technologies allow in-depth analysis of multiple facets of the proteome that have clinical relevance and that complement current genomics-based approaches. Although some progress has been made in our knowledge of the human proteome in health and in disease, there is an urgent need to chart a coherent road map with clearly defined milestones to guide proteomics efforts. Areas of emphasis include: (1) building resources, (2) filling gaps in our understanding of biological variation, and (3) systematically characterizing proteome alterations that occur in well-defined disease states, all of which require an organized and collaborative effort.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA. shanash@fhcrc.org
authors.forename: Sam
authors.initials: S
authors.lastname: Hanash
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D019295:Computational Biology / Q000639:trends*; D004194:Disease; D006801:Humans; D020543:Proteome / Q000032:analysis* / Q000378:metabolism; D040901:Proteomics
chemical_list: D001798:Blood Proteins; D020543:Proteome