title: A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA.
abstract: In order to expand target sequences in triplex DNA formation, the development of a nucleobase that recognizes a CG base pair in dsDNA was attempted. A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase was found to recognize a CG base pair with high sequence-selectivity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan. hari@phs.osaka-u.ac.jp
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hari
authors.forename: Masaaki
authors.initials: M
authors.lastname: Akabane
authors.forename: Yuri
authors.initials: Y
authors.lastname: Hatanaka
authors.forename: Motoi
authors.initials: M
authors.lastname: Nakahara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
mesh_terms: D020029:Base Pairing; D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000235:genetics; D011744:Pyrimidinones / Q000737:chemistry*; D013379:Substrate Specificity; D044366:Transition Temperature
chemical_list: C559581:4-((3R,4R)-dihydroxypyrrolidino)pyrimidin-2-one; D009838:Oligodeoxyribonucleotides; D011744:Pyrimidinones; C051802:triplex DNA; D004247:DNA