title: Intracranial bleeding due to vitamin K deficiency: advantages of using a pediatric intensive care registry.
abstract: OBJECTIVE
  To determine the incidence of late intracranial vitamin K deficiency bleeding (VKDB) in The Netherlands using the Dutch Pediatric Intensive Care Evaluation (PICE) registry.
  
  
  METHODS
  The PICE registry was used to identify all infants who were admitted to a Dutch pediatric intensive care unit (PICU) with intracranial bleeding between 1 January 2004 and 31 December 2007. Cases of confirmed late intracranial VKDB were used to calculate the incidence for each year. To estimate the completeness of ascertainment of the PICE registry, data from 2005 were compared with general surveillance data from that year.
  
  
  RESULTS
  In the 4-year study period, 16/64 (25%) of the infants admitted with intracranial bleeding had late intracranial VKDB, resulting in an overall incidence of 2.1/100,000 live births (95% confidence interval 1.2-3.5). The single-year incidence varied markedly between 0.5 and 3.3 per 100,000 live births. All five ascertained cases in 2005 were identified using the PICE registry, while general surveillance identified only three.
  
  
  CONCLUSIONS
  The PICE registry allows ongoing monitoring of the incidence of late intracranial VKDB and appears to be associated with a higher rate of completeness than general surveillance. We propose the use of pediatric intensive care registries to assess the efficacy of national vitamin K prophylactic regimens.
authors.affiliation: Department of Pediatric Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KC 03.063.0, PO Box 85090, 3508 AB Utrecht, The Netherlands.
authors.forename: Désirée Y
authors.initials: DY
authors.lastname: Visser
authors.forename: Nicolaas J
authors.initials: NJ
authors.lastname: Jansen
authors.forename: Marloes M
authors.initials: MM
authors.lastname: Ijland
authors.forename: Tom J
authors.initials: TJ
authors.lastname: de Koning
authors.forename: Peter M
authors.initials: PM
authors.lastname: van Hasselt
mesh_terms: D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D020300:Intracranial Hemorrhages / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011159:Population Surveillance; D012042:Registries; D006475:Vitamin K Deficiency Bleeding / Q000503:physiopathology*