title: Design principles for robust biochemical reaction networks: what works, what cannot work, and what might almost work.
abstract: We bring together recent results that connect the structure of a mass-action reaction network to its capacity for concentration robustness - that is, its capacity to keep the concentration of a critical bio-active species within narrow limits, even against large fluctuations in the overall supply of the network's constituents.
authors.affiliation: Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. guy.shinar@weizmann.ac.il
authors.forename: Guy
authors.initials: G
authors.lastname: Shinar
authors.forename: Martin
authors.initials: M
authors.lastname: Feinberg
mesh_terms: D000465:Algorithms; D001669:Biochemical Phenomena / Q000502:physiology*; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods*