title: Serial imaging and structure-function correlates of high-density rings of fundus autofluorescence in retinitis pigmentosa.
abstract: OBJECTIVE
  To document the evolution and functional and structural significance of parafoveal rings of high-density fundus autofluorescence (AF) in patients with retinitis pigmentosa and preserved visual acuity.
  
  
  METHODS
  Fifty-two patients with nonsyndromic retinitis pigmentosa or Usher syndrome, who had a parafoveal ring of high-density AF and a visual acuity of 20/30 or better, were ascertained. All had international standard full-field electroretinography and pattern electroretinography. Autofluorescence imaging was repeated in 30 patients after periods of up to 9.3 years. Of the 52 patients, 35 underwent optical coherence tomography.
  
  
  RESULTS
  Progressive constriction of the ring was detected in 17 patients. Ring radius reduced by up to 40% at a mean rate of between 0.8% and 15.8% per year. In 1 patient, a small ring was replaced by irregular AF; visual acuity deteriorated over the same period. There was a high correspondence between the lateral extent of the preserved optical coherence tomography inner segment/outer segment band and the diameter of the ring along the same optical coherence tomographic scan plane (slope, 0.9; r = 0.97; P < 0.005; n = 35) and between preserved inner segment/outer segment lamina and the pattern electroretinography P50 measure of macular function (R = 0.72; P < 0.005; n = 34).
  
  
  CONCLUSIONS
  Rings of increased AF surround areas of preserved outer retina and preserved photopic function. Serial fundus AF may provide prognostic indicators for preservation of central acuity and potentially assist in the identification and evaluation of patients suitable for treatment aimed at preservation of remaining function.
authors.affiliation: Moorfields Eye Hospital, London, UK. anthony.robson@moorfields.nhs.uk
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Robson
authors.forename: Adnan
authors.initials: A
authors.lastname: Tufail
authors.forename: Fred
authors.initials: F
authors.lastname: Fitzke
authors.forename: Alan C
authors.initials: AC
authors.lastname: Bird
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Moore
authors.forename: Graham E
authors.initials: GE
authors.lastname: Holder
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Webster
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018450:Disease Progression; D004596:Electroretinography; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008875:Middle Aged; D012160:Retina / Q000503:physiopathology*; D012174:Retinitis Pigmentosa / Q000175:diagnosis / Q000503:physiopathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult