title: Soluble IL-1RII and IL-18 are associated with incipient upper extremity soft tissue disorders.
abstract: Previous studies suggest a role for IL-1β in the pathophysiology of upper extremity soft tissue disorders (UESTDs). We studied the levels of interleukin-1 family members in patients with incipient UESTDs and compared them with healthy controls. In this case control study, we included 163 patients with UESTDs and symptom duration shorter than 1 month and 42 healthy controls matched for age and gender at the group level. Serum levels of cytokines IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-18, IL-33, TNFα and sensitized C-reactive protein as well as IL-1 family soluble receptors sIL-1RII and sST2 were assessed. We used unconditional logistic regression models to study the associations between cytokines and UESTDs. After adjustment for potential confounders, the serum levels of sIL-1RII (p<0.001) and sST2 (p=0.014) were higher in the patients than the controls. The level of IL-18 was lower in the patients than the controls (p=0.005). There were no significant differences between the patients and controls regarding the levels of IL-1α, IL-1β, IL-1Ra, IL-33, IL-6, IL-8, TNFα, or sensitized C-reactive protein. The levels of circulating sIL-1RII and IL-18 are associated with incipient UESTDs, suggesting an important role for these IL-1 family members in the early course of UESTDs.
authors.affiliation: Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland. martti.rechardt@ttl.fi
authors.forename: Martti
authors.initials: M
authors.lastname: Rechardt
authors.forename: Rahman
authors.initials: R
authors.lastname: Shiri
authors.forename: Sampsa
authors.initials: S
authors.lastname: Matikainen
authors.forename: Eira
authors.initials: E
authors.lastname: Viikari-Juntura
authors.forename: Jaro
authors.initials: J
authors.lastname: Karppinen
authors.forename: Harri
authors.initials: H
authors.lastname: Alenius
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003240:Connective Tissue Diseases / Q000097:blood*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D053574:Receptors, Interleukin-1 Type II / Q000097:blood*; D012995:Solubility; D034941:Upper Extremity / Q000473:pathology*
chemical_list: D020382:Interleukin-18; D053574:Receptors, Interleukin-1 Type II