title: Tissue expression of glycated apolipoprotein B in colorectal adenoma and cancer.
abstract: BACKGROUND
  Myocardial infarction and colorectal cancer are associated at the population level and in autoptic studies. Glycated apolipoprotein B (apoB) is a risk factor for the development of myocardial infarction. The association of glycated apoB with dysplastic and neoplastic colorectal tissue was investigated.
  
  
  METHODS
  Forty-eight consecutive surgical specimens, 26 colorectal adenomas and 22 colorectal carcinomas, retrieved from the archives of the Pathologic Anatomy Department of our institution, were examined. The tissue content of glycated apoB was determined using a monoclonal antibody.
  
  
  RESULTS
  Glycated apoB was detected in 27% of the adenomas and 45% of the cancer tissue, but only in 18% of the normal tissue near the cancer site.
  
  
  CONCLUSIONS
  Glycated apoB is associated with dysplastic and even more so with neoplastic cancer tissue.
authors.affiliation: Laboratory of Epidemiology and Biostatistics, National Institute for Digestive Diseases S de Bellis, Via Turi 27, 70013 Castellana G, BA, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Reddavide
authors.forename: Giovanni
authors.initials: G
authors.lastname: Misciagna
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Caruso
authors.forename: Maria
authors.initials: M
authors.lastname: Notarnicola
authors.forename: Raffaele
authors.initials: R
authors.lastname: Armentano
authors.forename: Maria Lucia
authors.initials: ML
authors.lastname: Caruso
authors.forename: Michele
authors.initials: M
authors.lastname: Pirrelli
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Valentini
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D018256:Adenomatous Polyps / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D017127:Glycation End Products, Advanced; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008077:Lipoproteins, LDL / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D000093844:Glycated Proteins
chemical_list: D017127:Glycation End Products, Advanced; D008077:Lipoproteins, LDL; C031797:glycated lipoproteins, LDL; D000093844:Glycated Proteins