title: DNA vaccination : tolerance and autoimmunity.
abstract: Infectious diseases result in significant morbidity and mortality worldwide. Preventing these infections is both a public health priority and the primary goal of vaccine research. The discovery that cell-mediated and/or humoral immune responses against viruses, parasites, bacteria and tumor antigens can be induced by antigen-encoding DNA plasmids is revolutionizing the vaccine development field (1-3). DNA vaccines (also known as plasmid DNA or nucleic acid vaccines) have been proven to successfully prevent infection in a variety of animal models, and are currently undergoing clinical trials in humans for the prevention of a variety of infections, including HIV (1,4,5).
authors.affiliation: Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT.
authors.forename: G
authors.initials: G
authors.lastname: Mor
authors.forename: M
authors.initials: M
authors.lastname: Eliza