title: Sleep in ventilatory failure in restrictive thoracic disorders. Effects of treatment with non invasive ventilation.
abstract: OBJECTIVE
  Hypercapnic ventilatory failure due to restrictive disorders may have a negative impact on sleep architecture. Non-invasive ventilation (NIV) may improve arterial blood gases but may adversely affect sleep. We assessed sleep structure and blood gases before and during NIV in patients with restrictive disorders in hypercapnic ventilatory failure.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Sleep laboratory of Saint-Luc University Hospital (Belgium).
  
  
  METHODS
  Chart review of all patients with predominantly restrictive disorders and respiratory failure seen between 1987 and 2008 and evaluated with a baseline polysomnography (PSG) and a PSG under NIV.
  
  
  RESULTS
  Sixty patients aged (mean±SD) 48±20 years, with total lung capacity of 57±20% of predicted value, PaO(2) of 62±16 mm Hg and PaCO(2) 54±10 mm Hg, were included. At baseline, total sleep time, sleep efficiency, slow wave and rapid-eye movement (REM) sleep were markedly decreased. Conversely, micro-arousals and stage I sleep (N1) were increased. NIV administered with volume-cycled (53%) or pressure-cycled (47%) ventilators improved daytime PaO(2), PaCO(2), pH and HCO(3)(-). In addition, sleep efficiency, REM sleep, mean and lowest nocturnal SpO(2) increased while stage 1, sleep fragmentation, and oxygen desaturation index decreased significantly.
  
  
  CONCLUSIONS
  Hypercapnic ventilatory failure in restrictive disorders profoundly affects sleep quality. NIV can improve not only blood gases, but also sleep architecture.
authors.affiliation: Division of Pulmonary Diseases, Geneva University Hospitals, 1211 Geneva 14, Switzerland.
authors.forename: Olivier
authors.initials: O
authors.lastname: Contal
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Janssens
authors.forename: Myriam
authors.initials: M
authors.lastname: Dury
authors.forename: Pierre
authors.initials: P
authors.lastname: Delguste
authors.forename: Geneviève
authors.initials: G
authors.lastname: Aubert
authors.forename: Daniel
authors.initials: D
authors.lastname: Rodenstein
mesh_terms: D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011175:Positive-Pressure Respiration; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D012189:Retrospective Studies; D012890:Sleep / Q000502:physiology; D012892:Sleep Deprivation / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D012895:Sleep, REM / Q000502:physiology