title: A new synthesis of pyrazoles through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines.
abstract: A new efficient and convenient approach toward the synthesis of pyrazoles is described. Through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines, a variety of pyrazole derivatives were prepared readily at ambient temperature with complete regioselectivity.
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Shan
authors.forename: Pengfei
authors.initials: P
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Rao
mesh_terms: D002384:Catalysis; D003503:Cyclobutanes / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis*
chemical_list: D003503:Cyclobutanes; D006834:Hydrazines; D058116:Lewis Acids; D011720:Pyrazoles