title: Clinical, bronchoscopic, histopathologic, diagnostic imaging, and arterial oxygenation findings in West Highland White Terriers with idiopathic pulmonary fibrosis.
abstract: BACKGROUND
  Idiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs).
  
  
  OBJECTIVE
  To describe the clinicopathological and diagnostic imaging features in WHWTs with IPF.
  
  
  METHODS
  Twelve WHWTs with IPF and 14 healthy control WHWTs.
  
  
  METHODS
  Prospective study. Clinical signs and findings of physical examination, blood and arterial blood gas analyses, radiography, high-resolution computed tomography (HRCT), bronchoscopy and bronchoalveolar lavage (BAL) of IPF dogs were obtained and compared with controls. Histopathologic changes in IPF dogs were evaluated.
  
  
  RESULTS
  Mean partial pressure of oxygen was significantly lower in IPF (mean ± SD, 65.5 ± 15.4 mmHg) than in controls (99.1 ± 7.8 mmHg, P<.001). The alveolar-arterial oxygen gradient was significantly higher in IPF (50.1 ± 17.3 mmHg) than in controls (17.5 ± 4.9 mmHg, P<.001). In HRCT, ground glass opacity (GGO) was detected in all IPF dogs, traction bronchiectasis in 4, and honeycombing in 1. Bronchoscopic airway changes were noted in all IPF dogs. On BAL fluid (BALF) cytology, the total cell count (TCC) was higher in IPF dogs, and the numbers but not the percentages of macrophages, neutrophils, and mast cells were increased. On histopathology, multifocal or diffuse interstitial fibrosis, type II pneumocyte hyperplasia, prominent intraalveolar macrophages, distortion of alveolar architecture, and emphysematous change were detected.
  
  
  CONCLUSIONS
  IPF causes substantial hypoxemia. In HRCT, GGO is a consistent finding. IPF dogs have concurrent airway changes and an increase in BALF TCC.
authors.affiliation: Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland. henna.heikkila@helsinki.fi
authors.forename: H P
authors.initials: HP
authors.lastname: Heikkilä
authors.forename: A K
authors.initials: AK
authors.lastname: Lappalainen
authors.forename: M J
authors.initials: MJ
authors.lastname: Day
authors.forename: C
authors.initials: C
authors.lastname: Clercx
authors.forename: M M
authors.initials: MM
authors.lastname: Rajamäki
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D001999:Bronchoscopy / Q000662:veterinary*; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D008168:Lung / Q000473:pathology; D008297:Male; D010100:Oxygen / Q000097:blood*; D011446:Prospective Studies; D011658:Pulmonary Fibrosis / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D013902:Radiography, Thoracic / Q000662:veterinary; D014057:Tomography, X-Ray Computed / Q000662:veterinary
chemical_list: D010100:Oxygen