title: Hippo signalling: liver size regulation and beyond.
abstract: After its discovery in Drosophila, the Hippo signalling pathway has been shown to regulate organ size in mammals as well. Based on recent studies, this kinase cascade appears in particular crucial for liver tissue homeostasis, by regulating both cellular proliferation and apoptosis. Thereby, Hippo signalling may appear as a key pathway in liver carcinogenesis.
authors.affiliation: Inserm U757, université Paris-sud, bâtiment 443, 91405 Orsay, France. thierry.tordjmann@u-psud.fr
authors.forename: T
authors.initials: T
authors.lastname: Tordjmann
mesh_terms: D000818:Animals; D006801:Humans; D008099:Liver / Q000254:growth & development*; D008113:Liver Neoplasms / Q000209:etiology; D009929:Organ Size; D011494:Protein Kinases / Q000502:physiology*
chemical_list: D011494:Protein Kinases