title: Antibody persistence and immune memory 4 years post-vaccination with combined hepatitis A and B vaccine in adults aged over 40 years.
abstract: Persistence of immune response was assessed in adults aged >40 years (N = 596) following primary vaccination with combined hepatitis A/B vaccine or concomitant monovalent hepatitis A and B vaccines. Anti-hepatitis A virus antibody responses persisted for at least 4 years regardless of the vaccine used, with anti-hepatitis B surface antibody responses higher and more sustained in subjects who received the combined hepatitis A/B vaccine. Response rates to an additional dose of the same vaccine(s) used for priming were high.
authors.affiliation: Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic. chlibek@pmfhk.cz
authors.forename: Roman
authors.initials: R
authors.lastname: Chlibek
authors.forename: Frank
authors.initials: F
authors.lastname: von Sonnenburg
authors.forename: Pierre
authors.initials: P
authors.lastname: Van Damme
authors.forename: Jan
authors.initials: J
authors.lastname: Smetana
authors.forename: Petr
authors.initials: P
authors.lastname: Tichy
authors.forename: Bhavyashree
authors.initials: B
authors.lastname: Gunapalaiah
authors.forename: Maarten
authors.initials: M
authors.lastname: Leyssen
authors.forename: Jeanne-Marie
authors.initials: JM
authors.lastname: Jacquet
mesh_terms: D000328:Adult; D005260:Female; D006506:Hepatitis A / Q000517:prevention & control; D035922:Hepatitis A Antibodies / Q000097:blood*; D022362:Hepatitis A Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006509:Hepatitis B / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D007156:Immunologic Memory; D008297:Male; D008875:Middle Aged; D017778:Vaccines, Combined / Q000276:immunology
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D017778:Vaccines, Combined