title: Identification and in vitro anti-esophageal cancer activity of a series of halogenated monoterpenes isolated from the South African seaweeds Plocamium suhrii and Plocamium cornutum.
abstract: Five known (1, 2, 4, 6 and 7) halogenated monoterpenes together with 1Z,3R∗,4S∗,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene (3) and (3R∗,4S∗)-3,4,6,7-tetrachloro-3,7-dimethyl-octen-1-ene (5) were isolated from the red macroalga Plocamium suhrii and their structures deduced from their spectroscopic data. The seven compounds from P. suhrii together with five related compounds from Plocamium cornutum have been evaluated for their cytotoxic effects on an esophageal cancer cell line (WHCO1). Compounds 1-6 showed greater cytotoxicity in this assay as compared to the known anticancer drug cisplatin.
authors.affiliation: Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa.
authors.forename: Edith M
authors.initials: EM
authors.lastname: Antunes
authors.forename: Anthonia F
authors.initials: AF
authors.lastname: Afolayan
authors.forename: Maynard T
authors.initials: MT
authors.lastname: Chiwakata
authors.forename: Jameel
authors.initials: J
authors.lastname: Fakee
authors.forename: Michael G
authors.initials: MG
authors.lastname: Knott
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Whibley
authors.forename: Denver T
authors.initials: DT
authors.lastname: Hendricks
authors.forename: John J
authors.initials: JJ
authors.lastname: Bolton
authors.forename: Denzil R
authors.initials: DR
authors.lastname: Beukes
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044725:Plocamium / Q000737:chemistry*; D013019:South Africa
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006846:Hydrocarbons, Halogenated; D039821:Monoterpenes; D002945:Cisplatin