title: Occlusive IOLs for intractable diplopia demonstrate a novel near-infrared window of transmission for SLO/OCT imaging and clinical assessment.
abstract: OBJECTIVE
  Occlusive intraocular lens (IOL) implantation is an effective therapeutic option in patients with intractable diplopia, visual confusion, and unsightly leukocoria. However, their use has been restricted by concerns that inability to visualize the retina may prevent the diagnosis of important posterior pole diseases. In this study, transmission spectra of occlusive IOLs were defined as a basis for acquiring scanning laser ophthalmoscopy/optical coherence tomography (SLO/OCT) images.
  
  
  METHODS
  Fifteen IOLs of three designs were examined: black small and large PMMA and black Lotus (Morcher GmbH, Stuttgart, Germany). Each IOL was placed between a broad-spectrum white light source and a spectroradiometer, to generate transmission spectra for each lens and determine the cutoff wavelength. Transmission in the near-infrared (NIR) range was confirmed with an 850-nm LED. A model eye was implanted with occlusive IOLs, and SLO/OCT scans were acquired with seven clinical SLO/OCT imaging systems.
  
  
  RESULTS
  Occlusive IOLs demonstrated high levels of transmission of NIR light. It was determined that most SLO/OCT scanners would achieve 99% to 100% transmission at their operational wavelengths of NIR light. Furthermore, all clinical SLO/OCT imaging systems were capable of imaging fine retinal features without attenuation through occlusive IOLs in a model eye.
  
  
  CONCLUSIONS
  In this study, a novel NIR window of high-level transmission was identified across the occlusive IOLs with applications to SLO/OCT imaging and NIR-based clinical assessment. The ability to acquire high-quality SLO/OCT scans to detect posterior pole disease may fundamentally change the current view on occlusive IOLs and encourage their use in patients with intractable diplopia.
authors.affiliation: Nuffield Laboratory of Ophthalmology, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom.
authors.forename: Imran H
authors.initials: IH
authors.lastname: Yusuf
authors.forename: Stuart N
authors.initials: SN
authors.lastname: Peirson
authors.forename: C K
authors.initials: CK
authors.lastname: Patel
mesh_terms: D004172:Diplopia / Q000601:surgery*; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008954:Models, Biological; D008962:Models, Theoretical; D009887:Ophthalmoscopy; D055095:Optics and Photonics; D019904:Polymethyl Methacrylate; D011474:Prosthesis Design; D041623:Tomography, Optical Coherence
chemical_list: D019904:Polymethyl Methacrylate