title: Synthesis and biological evaluation of PMMA/MMT nanocomposite as denture base material.
abstract: Inorganic-polymer nanocomposites are of significant interest for emerging materials due to their improved properties and unique combination of properties. Poly (methylmethacrylate) (PMMA)/montmorillonite (MMT) nanocomposites were prepared by in situ suspension polymerization with dodecylamine used as MMT-modifier. X-ray diffraction (XRD) and transmission electron microscopy (TEM) were used to characterize the structures of the nanocomposites. Cytotoxicity test, hemolysis test, acute systemic toxicity test, oral mucous membrane irritation test, guinea-pig maximization test and mouse bone-marrow micronucleus test were used to evaluate the biocompatibility of PMMA/MMT nanocomposites. The results indicated that an exfoliated nanocomposite was achieved, and the resulting nanocomposites exhibited excellent biocompatibility as denture base material and had potential application in dental materials.
authors.affiliation: Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People's Republic of China. jpzheng@tju.edu.cn
authors.forename: Junping
authors.initials: J
authors.lastname: Zheng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Su
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.forename: Ran
authors.initials: R
authors.lastname: Zhu
authors.forename: Jin
authors.initials: J
authors.lastname: Shi
authors.forename: Kangde
authors.initials: K
authors.lastname: Yao
mesh_terms: D000818:Animals; D001546:Bentonite / Q000737:chemistry*; D001672:Biocompatible Materials; D001854:Bone Marrow Cells / Q000166:cytology; D002522:Chlorocebus aethiops; D003819:Denture Bases; D005260:Female; D006168:Guinea Pigs; D006461:Hemolysis; D008297:Male; D008422:Materials Testing; D051379:Mice; D015162:Micronucleus Tests; D009061:Mouth Mucosa / Q000378:metabolism; D053761:Nanocomposites / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D011108:Polymers; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D051381:Rats; D014709:Vero Cells
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D001546:Bentonite; D019904:Polymethyl Methacrylate