title: The importance of defining serum MMP-9 concentration in diabetics as an early marker of the rupture of atheromatous plaque in acute coronary syndrome.
abstract: Acute coronary syndrome (ACS) is the main cause of mortality in diabetics. Acute myocardial infarction (AMI) in diabetics is much more often than in non-diabetics. MMP-9 activity could ease the formation of atherosclerosis, destabilization and plaque rupture as well as thrombocyte aggregation.
  MMP-9 defining in serum in diabetics; the impact of diabetes mellitus on atherosclerosis and MMP-9 level; relation between serum values of MMP-9 and markers of glycoregulation and lipid status, respectively.
  
  
  RESULTS
  The greatest concentration of both total and active MMP-9 serum has been noted in diabetics group with ACS. Both total and active MMP-9 values, in group with diabetes and ACS showed significantly important difference regarding the values in control group. Total and active MMP-9 showed statistically important correlation between the values of glycated hemoglobine A1c (HbA1c) and inverse correlations with values of subfraction HDL3.Active MMP-9 showed statistically important inverse correlation with value of HDL cholesterol.
  
  
  CONCLUSIONS
  According to the results, it has been thought that active MMP-9 shows a certain degree of atherosclerotic changes on blood vessels better than total MMP-9. MMP-9, active one, could present an early marker of atherosclerosis, especially on coronary blood vessels, in diabetics with type 2.
authors.affiliation: Institute for Endocrinology, Diabetes and Metabolism Disorders, Belgrade, Serbia.
authors.forename: D
authors.initials: D
authors.lastname: Gostiljac
authors.forename: P B
authors.initials: PB
authors.lastname: Dorđević
authors.forename: D
authors.initials: D
authors.lastname: Djurić
authors.forename: J
authors.initials: J
authors.lastname: Peruničić
authors.forename: R
authors.initials: R
authors.lastname: Lasica
authors.forename: E
authors.initials: E
authors.lastname: Colak
authors.forename: F
authors.initials: F
authors.lastname: Canovic
authors.forename: V D
authors.initials: VD
authors.lastname: Srećković
authors.forename: M
authors.initials: M
authors.lastname: Ilić
authors.forename: R
authors.initials: R
authors.lastname: Obrenović
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000201:enzymology*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000201:enzymology*; D003920:Diabetes Mellitus / Q000097:blood / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000201:enzymology; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000201:enzymology*
chemical_list: D015415:Biomarkers; D020780:Matrix Metalloproteinase 9