title: Hypoxia: jump-starting inflammation.
abstract: Tissue hypoxia affects immunity and inflammation; however, the way in which changes in oxygen levels may modulate dendritic cell (DC) function is still not clear. Bosco et al report the gene expression profiling of hypoxic mature DCs and identify TREM-1 as a novel hypoxia-inducible gene that may amplify inflammatory responses.
authors.affiliation: Saic Frederick Inc, NCI, Frederick, USA.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Melillo