title: Cytokines expression in SLE nephritis.
abstract: Renal involvement is a common manifestation in course of systemic lupus erythematous (SLE) and may occur at any time. In SLE nephritis, the pattern of glomerular injury is primarily related to the formation of the immune deposits in situ, due major to antidouble-stranded DNA (anti-dsDNA) antibodies and anti- C1q. Immune complexes deposits can induce the inflammatory response by activation of adhesion molecules on endothelium, resulting in the recruitment of pro inflammatory leukocytes. Activated and damaged glomerular cells, infiltrating macrophages, B and T cells produced cytokines that play a pivotal role as inflammatory mediators to extend renal injury. In serum of SLE patients, the concentrations of IL-6, IL-17, IL-12, INF-gamma, IL-18, IL-10 and TNF-alpha are higher than healthy people and this increase correlate with disease activity. It is well established possible correlation between urinary cytokines levels (IL-6, IL-10, INF-gamma and TGF-beta) and disease activity. In fact, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) correlate with cytokines over-expression, in particular IL-17, IL-10, TNF-alpha and the axis INF-gamma/IL-12. Recent studies are promising about proteinuria reduction and improving renal function through cytokine blockade therapy.
authors.affiliation: Department of Clinical Medicine, "Sapienza" University, Rome, Italy. antonietta_gigante@yahoo.it
authors.forename: A
authors.initials: A
authors.lastname: Gigante
authors.forename: M L
authors.initials: ML
authors.lastname: Gasperini
authors.forename: A
authors.initials: A
authors.lastname: Afeltra
authors.forename: B
authors.initials: B
authors.lastname: Barbano
authors.forename: D
authors.initials: D
authors.lastname: Margiotta
authors.forename: R
authors.initials: R
authors.lastname: Cianci
authors.forename: I
authors.initials: I
authors.lastname: De Francesco
authors.forename: A
authors.initials: A
authors.lastname: Amoroso
mesh_terms: D001706:Biopsy; D016207:Cytokines / Q000032:analysis* / Q000502:physiology; D006801:Humans; D008181:Lupus Nephritis / Q000209:etiology / Q000276:immunology* / Q000473:pathology
chemical_list: D016207:Cytokines