title: S-nitrosylation-regulated GPCR signaling.
abstract: G protein-coupled receptors (GPCRs) are the most numerous and diverse type of cell surface receptors, accounting for about 1% of the entire human genome and relaying signals from a variety of extracellular stimuli that range from lipid and peptide growth factors to ions and sensory inputs. Activated GPCRs regulate a multitude of target cell functions, including intermediary metabolism, growth and differentiation, and migration and invasion. The GPCRs contain a characteristic 7-transmembrane domain topology and their activation promotes complex formation with a variety of intracellular partner proteins, which form basis for initiation of distinct signaling networks as well as dictate fate of the receptor itself. Both termination of active GPCR signaling and removal from the plasma membrane are controlled by protein post-translational modifications of the receptor itself and its interacting partners. Phosphorylation, acylation and ubiquitination are the most studied post-translational modifications involved in GPCR signal transduction, subcellular trafficking and overall expression. Emerging evidence demonstrates that protein S-nitrosylation, the covalent attachment of a nitric oxide moiety to specified cysteine thiol groups, of GPCRs and/or their associated effectors also participates in the fine-tuning of receptor signaling and expression. This newly appreciated mode of GPCR system modification adds another set of controls to more precisely regulate the many cellular functions elicited by this large group of receptors. This article is part of a Special Issue entitled: Regulation of cellular processes by S-nitrosylation.
authors.affiliation: The Department of Microbiology and Immunology, University of California, San Francisco, CA, United States. ydaaka@ufl.edu
authors.forename: Yehia
authors.initials: Y
authors.lastname: Daaka
mesh_terms: D019390:Arrestins / Q000378:metabolism; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism; D034281:Dynamins / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism; D015538:Nitrosation; D011499:Protein Processing, Post-Translational; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D000071557:beta-Arrestins
chemical_list: D019390:Arrestins; D043562:Receptors, G-Protein-Coupled; D000071557:beta-Arrestins; D009569:Nitric Oxide; D034281:Dynamins; D003545:Cysteine