title: Point of care testing in children undergoing cardiopulmonary bypass.
abstract: BACKGROUND
  Excessive hemorrhage is a major complication after cardiac surgery requiring cardiopulmonary bypass (CPB). The aim of this study was to define the potential role of the cone and platelet analyzer (CPA) and the rotating thromboelastogram (ROTEM) point of care tests in children undergoing CPB.
  
  
  METHODS
  We prospectively studied 15 pediatric patients aged 1 month to 10 years. Blood count, blood coagulation tests (prothrombin time [PT], activated partial thromboplastin time, fibrinogen, thrombin time), CPA and ROTEM parameters were measured before and after CPB. Demographic and surgical data were recorded as were those on perioperative blood loss and blood product transfusion.
  
  
  RESULTS
  Low body weight, longer duration on CPB and lower core body temperature were associated with an increased bleeding risk. The ROTEM test showed a significant prolongation of clotting time and decreased maximal clot firmness (MCF) postoperatively in children with increased bleeding. The coagulation parameters associated with increased bleeding were: prolonged PT, lower fibrinogen levels, prior to surgery, and lower MCF after surgery. CPA test findings were not associated with postoperative bleeding in our patients.
  
  
  CONCLUSIONS
  CPA did not serve as a prognostic tool for predicting bleeding risk in children undergoing CPB. The change in ROTEM's post-CPB results associated with bleeding tendency, and they may predict for poorer clot formation and stability.
authors.affiliation: Department of Pediatrics of the Edmond and Lily Safra Children's Hospital, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Tirosh-Wagner
authors.forename: Tzipi
authors.initials: T
authors.lastname: Strauss
authors.forename: Marina
authors.initials: M
authors.lastname: Rubinshtein
authors.forename: Ilia
authors.initials: I
authors.lastname: Tamarin
authors.forename: David
authors.initials: D
authors.lastname: Mishaly
authors.forename: Gideon
authors.initials: G
authors.lastname: Paret
authors.forename: Gili
authors.initials: G
authors.lastname: Kenet
mesh_terms: D001780:Blood Coagulation Tests; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010976:Platelet Count; D019095:Point-of-Care Systems; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D011379:Prognosis; D011446:Prospective Studies; D013916:Thrombelastography