title: Amphiphilic polymer-coated hybrid nanoparticles as CT/MRI dual contrast agents.
abstract: We describe hybrid nanoparticles, composed of iron oxide and gold nanoparticles, as potential dual contrast agents for both computed tomography (CT) and magnetic resonance imaging (MRI). The hybrid nanoparticles are synthesized by thermal decomposition of mixtures of Fe-oleate and Au-oleylamine complexes. Using a nano-emulsion method, the nanoparticles are coated with amphiphilic poly(DMA-r-mPEGMA-r-MA) to impart water-dispersity and antibiofouling properties. An in vitro phantom study shows that the hybrid nanoparticles have high CT attenuation, because of the constituent gold nanoparticles, and afford a good MR signal, attributable to the contained iron oxide nanoparticles. Intravenous injection of the hybrid nanoparticles into hepatoma-bearing mice results in high contrast between the hepatoma and normal hepatic parenchyma in both CT and MRI. These results suggest that the hybrid nanoparticles may be useful as CT/MRI dual contrast agents for in vivo hepatoma imaging.
authors.affiliation: Cell Dynamics Research Center, Research Center for Biomolecular Nanotechnology, School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 261 Chemdan-gwagiro, Gwangju 500-712, Republic of Korea.
authors.forename: Dongkyu
authors.initials: D
authors.lastname: Kim
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Yu
authors.forename: Tae Sup
authors.initials: TS
authors.lastname: Lee
authors.forename: Jae Jun
authors.initials: JJ
authors.lastname: Park
authors.forename: Yong Yeon
authors.initials: YY
authors.lastname: Jeong
authors.forename: Sangyong
authors.initials: S
authors.lastname: Jon
mesh_terms: D000588:Amines / Q000737:chemistry; D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D008027:Light; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000473:pathology; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D051379:Mice; D008815:Mice, Inbred Strains; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012542:Scattering, Radiation; D012995:Solubility; D013053:Spectrophotometry; D014057:Tomography, X-Ray Computed
chemical_list: D000588:Amines; D003287:Contrast Media; D058185:Magnetite Nanoparticles; D008689:Methacrylates; D011108:Polymers; C115846:dodecyl methacrylate; C524499:polyethylene glycol methacrylate; C008384:methacrylic acid; D011092:Polyethylene Glycols; D006046:Gold; C008703:oleylamine