title: Genetic variations of interleukin-1 and -6 genes and risk of cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  To evaluate the association between five interleukin-1 (IL-1) and -6 gene polymorphisms and risk of high grade cervical intraepithelial neoplasia (CIN 2-3).
  
  
  METHODS
  This case-control study investigates five common IL-1 and IL-6 gene polymorphisms in 131 women with CIN 2-3 and 209 controls by pyrosequencing and polymerase chain reaction. Associations between gene polymorphisms and risk of CIN 2-3 are analysed by univariate and multivariable models. Their combined effect on the risk of CIN is evaluated by haplotype analysis.
  
  
  RESULTS
  In a multivariable regression model IL1A -889 (odds ratio 0.3 [95% confidence interval 0.1-0.8], p=0.01) and smoking (4.0 [1.7-9.1], p=0.001) are independently associated with the risk of high grade CIN. Haplotype analysis does not reveal any high-risk combinations for the susceptibility of CIN.
  
  
  CONCLUSIONS
  The single nucleotide polymorphism IL1A -889 is independently associated with risk of high grade CIN.
authors.affiliation: Department of Gynecology and Gynecological Oncology, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria. christoph.grimm@meduniwien.ac.at
authors.forename: Christoph
authors.initials: C
authors.lastname: Grimm
authors.forename: Rafal
authors.initials: R
authors.lastname: Watrowski
authors.forename: Konstantin
authors.initials: K
authors.lastname: Baumühlner
authors.forename: Camilla
authors.initials: C
authors.lastname: Natter
authors.forename: Dan
authors.initials: D
authors.lastname: Tong
authors.forename: Andrea
authors.initials: A
authors.lastname: Wolf
authors.forename: Robert
authors.initials: R
authors.lastname: Zeillinger
authors.forename: Sepp
authors.initials: S
authors.lastname: Leodolter
authors.forename: Alexander
authors.initials: A
authors.lastname: Reinthaller
authors.forename: Lukas
authors.initials: L
authors.lastname: Hefler
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000276:immunology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000276:immunology
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6