title: 1H and 10B NMR and MRI investigation of boron- and gadolinium-boron compounds in boron neutron capture therapy.
abstract: (10)B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include (1)H and (10)B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.
authors.affiliation: Physics Department A. Volta, University of Pavia, Pavia, Italy. marco.bonora@unipv.it
authors.forename: M
authors.initials: M
authors.lastname: Bonora
authors.forename: M
authors.initials: M
authors.lastname: Corti
authors.forename: F
authors.initials: F
authors.lastname: Borsa
authors.forename: S
authors.initials: S
authors.lastname: Bortolussi
authors.forename: N
authors.initials: N
authors.lastname: Protti
authors.forename: D
authors.initials: D
authors.lastname: Santoro
authors.forename: S
authors.initials: S
authors.lastname: Stella
authors.forename: S
authors.initials: S
authors.lastname: Altieri
authors.forename: C
authors.initials: C
authors.lastname: Zonta
authors.forename: A M
authors.initials: AM
authors.lastname: Clerici
authors.forename: L
authors.initials: L
authors.lastname: Cansolino
authors.forename: C
authors.initials: C
authors.lastname: Ferrari
authors.forename: P
authors.initials: P
authors.lastname: Dionigi
authors.forename: A
authors.initials: A
authors.lastname: Porta
authors.forename: G
authors.initials: G
authors.lastname: Zanoni
authors.forename: G
authors.initials: G
authors.lastname: Vidari
mesh_terms: D000818:Animals; D001895:Boron; D016754:Boron Neutron Capture Therapy; D005682:Gadolinium; D007554:Isotopes; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009374:Neoplasms, Experimental / Q000378:metabolism; D011522:Protons; D051381:Rats
chemical_list: D007554:Isotopes; D011522:Protons; D005682:Gadolinium; D001895:Boron