title: Could serum measurements of S100 proteins be reliable markers to predict recurrence in meningiomas?
abstract: Predicting which meningiomas will recur and which will not is clinically important, and still represents a major clinical challenge. A number of different molecular, genetic, and/or biochemical markers involved in cell proliferation, invasion, angiogenesis, and cell transformation have been investigated in attempts to predict the risk of post-surgical meningioma recurrence. In this short review we emphasize what has actually been accomplished in this area. Finally, we highlight the potential of S100 serum protein concentrations as a prognostic factor predicting meningioma recurrence. We conclude that serum concentrations of S100 group proteins may prove to be useful as prognostic markers and suggest further prospective trials be done.
authors.affiliation: Service de Neurochirurgie, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.
authors.forename: Laurence
authors.initials: L
authors.lastname: Abeloos
authors.forename: Florence
authors.initials: F
authors.lastname: Lefranc
mesh_terms: D015415:Biomarkers / Q000097:blood; D006801:Humans; D008579:Meningioma / Q000097:blood* / Q000175:diagnosis*; D011379:Prognosis; D012008:Recurrence; D009418:S100 Proteins / Q000097:blood*
chemical_list: D015415:Biomarkers; D009418:S100 Proteins