title: [Clinical analysis of esophageal cancer associated with other primary cancers].
abstract: This study aims to investigate the therapeutic and prognostic implications of esophageal cancer in patients with other primary cancer. Between April 1992 and December 2008, in 83 patients underwent surgery for esophageal cancer at our department. Among them, 24 patients (28.9%) had medical history of additional primary cancer. There were 16 metachronous cancers and 8 synchronous cancers. Six patients had antecedent other primary cancers, and subsequent primary cancers developed in 10 patients. The other primary cancers included head and neck cancer in 8 patients, gastric cancer in 8, lung cancer in 6, colorectal cancer in 3, and other cancer in 3. The patients with other primary cancers were both heavy smokers and heavy drinkers in comparison to those without other primary cancers. The post-operative 5-year survival rate in patients with subsequent cancers, antecedent cancers, and synchronous cancers were 100%, 70.0%, and 46.9%. The 5-year survival rate was 33.4% in patients without other primary cancers. A high incidence of multiple primary cancers was observed in patients with esophageal carcinoma but the prognosis of these patients with metachronous cancers are better than that of patient with synchronous cancers and patients without other primary cancers. Post-operative follow up is considered to be necessary for early detection of multiple occurrences of carcinoma, especially in the upper aerodigestive tract.
authors.affiliation: Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Ono
authors.forename: Masaru
authors.initials: M
authors.lastname: Takenaka
authors.forename: Erina
authors.initials: E
authors.lastname: Yokoyama
authors.forename: Soichi
authors.initials: S
authors.lastname: Oka
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Baba
authors.forename: Tetsuya
authors.initials: T
authors.lastname: So
authors.forename: Tomoko
authors.initials: T
authors.lastname: So
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Uramoto
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Takenoyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hanagiri
authors.forename: Kosei
authors.initials: K
authors.lastname: Yasumoto
mesh_terms: D000368:Aged; D004938:Esophageal Neoplasms / Q000401:mortality* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate