title: Expression of laminin receptor 1 in human placentas from normal and preeclamptic pregnancies and its relationship with the severity of preeclampsia.
abstract: To investigate the expression of laminin receptor 1 (LR1), a non-integrin-type laminin receptor, in preeclamptic and normal third-trimester placentas, as well as to investigate whether its expression differs with disease severity.
  
  
  
  Third trimester placental samples obtained from deliveries of preeclamptic (n=34) and normotensive healthy pregnant women (n=35) were immunohistochemically studied for the expression of LR1. The placentas from both mild (n=14) and severe (n=20) preeclamptic pregnancies were further assessed for strength of LR1 expression according to disease severity.
  
  
  
  When compared with normal placentas, the staining with LR1 protein in cytotrophoblasts and syncytiotrophoblasts was lower in preeclamptic placentas (P<0.05 and P<0.01, respectively). The intensity of staining with LR1 in decidual cells, cytotrophoblasts, syncytiotrophoblasts, and extracellular matrix cells of preeclamptic placentas did not vary with disease severity (P>0.05).
  
  
  
  Decreased LR1 expression in cytotrophoblasts and syncytiotrophoblasts of preeclamptic placentas, which may be independent of disease severity, might have a role in shallow trophoblastic invasion in preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Yuzuncu Yil University School of Medicine, Van, Turkey. mkurdoglu@yyu.edu.tr
authors.forename: Mertihan
authors.initials: M
authors.lastname: Kurdoglu
authors.forename: Zehra
authors.initials: Z
authors.lastname: Kurdoglu
authors.forename: Suleyman
authors.initials: S
authors.lastname: Ozen
authors.forename: Zehra
authors.initials: Z
authors.lastname: Kucukaydin
authors.forename: Gulay
authors.initials: G
authors.lastname: Bulut
authors.forename: Remzi
authors.initials: R
authors.lastname: Erten
authors.forename: Mansur
authors.initials: M
authors.lastname: Kamaci
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011225:Pre-Eclampsia / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D017474:Receptors, Laminin / Q000378:metabolism; D012016:Reference Values; D012269:Ribosomal Proteins; D014327:Trophoblasts / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: C510624:RPSA protein, human; D017474:Receptors, Laminin; D012269:Ribosomal Proteins