title: Evaluation of Nrf2 and IGF-1 expression in benign, premalignant and malignant gastric lesions.
abstract: The aim of this study was to investigate the expression of Nrf2 and IGF-1 in benign, premalignant, and malignant gastric lesions, and to explore the role of Nrf2 and IGF-1 in gastric carcinoma carcinogenesis. Nrf2 and IGF-1 expression was detected in normal gastric mucosa, hyperplastic polyp, intraepithelial neoplasia, and adenocarcinoma by immunohistochemistry. There was no expression of Nrf2 and IGF-1 in normal gastric mucous membrane. With the elevation of Nrf2, IGF-1 expression, their co-expressions were highly elevated from benign proliferative lesions to malignant lesions. There were significant differences between hyperplastic polyps, intraepithelial neoplasias, and adenocarcinoma (hyperplastic polys vs. intraepithelial neoplasia: P=0.012; hyperplastic polyps vs. adenocarcinoma: P=0.023; and intraepithelial neoplasia vs. adenocarcinoma: P=0.027; hyperplastic polyps vs. adenocarcinoma: P=0.0000, respectively). Nrf2 expression and IGF-1 expression were correlated positively (r=0.337, P=0.037). The increased expression of Nrf2 and IGF-1 may be related to gastric carcinogenesis. Elevated Nrf2 and IGF-1 may play important roles in promoting tumor progression.
authors.affiliation: Department of Digestive Disease, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan, Shandong 250033, PR China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Wang
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Zhou
authors.forename: Su-zhen
authors.initials: SZ
authors.lastname: Song
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Wei-hua
authors.initials: WH
authors.lastname: Xu
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Kong-xi
authors.initials: KX
authors.lastname: Zhu
authors.forename: Wei-hua
authors.initials: WH
authors.lastname: Yu
authors.forename: Hong-lei
authors.initials: HL
authors.lastname: Wu
authors.forename: Hong-juan
authors.initials: HJ
authors.lastname: Wang
authors.forename: Sen
authors.initials: S
authors.lastname: Lin
authors.forename: Jian-qiang
authors.initials: JQ
authors.lastname: Guo
authors.forename: Cheng-yong
authors.initials: CY
authors.lastname: Qin
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D002278:Carcinoma in Situ / Q000737:chemistry* / Q000473:pathology; D049109:Cell Proliferation; D002681:China; D018450:Disease Progression; D005753:Gastric Mucosa / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D051267:NF-E2-Related Factor 2 / Q000032:analysis*; D009367:Neoplasm Staging; D011127:Polyps / Q000737:chemistry* / Q000473:pathology; D011230:Precancerous Conditions / Q000737:chemistry* / Q000473:pathology; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D007334:Insulin-Like Growth Factor I