title: Effect of TNF-α and IL-1β genetic variants on the development of myocardial infarction in Turkish population.
abstract: Tumor necrosis factor-alpha (TNF-α) and interleukin 1 beta (IL-1β) genetic variants which resulting in TNF-α and IL-1 overproduction may increase susceptibility to autoimmune diseases such as atherosclerosis. We have studied the association of TNF-α G308A and IL-1β (+3953) C/T polymorphism with myocardial infarction in Turkish population. 143 patients with myocardial infarction and 213 age-matched healthy controls were included in the study. In univariant analysis, the frequencies of IL-1β, TNF-α genotype or allele, and haplotype of C:A and T:A were significantly elevated in patients when compared with those of controls. GA genotype of TNF-α, T allele of IL-1β and A of TNF-α allele seem to be risk factors for myocardial infarction. In contrast, CC genotype of IL-1β and GG genotype of TNF-α have protective effect against myocardial infarction. In multivariate logistic regression analysis, TNF-α A allele, gender and smoking were associated with myocardial infarction. In conclusion, we can state that TNF-α A allele might be associated with myocardial infarction.
authors.affiliation: Institute for Experimental Medicine, Department of Molecular Medicine, Istanbul University, Capa, 34390 Istanbul, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Zeybek
authors.forename: Bahar
authors.initials: B
authors.lastname: Toptas
authors.forename: Zeynep Ermis
authors.initials: ZE
authors.lastname: Karaali
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kendir
authors.forename: Bedia
authors.initials: B
authors.lastname: Cakmakoglu
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D014421:Turkey
chemical_list: D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha