title: [Single nucleotide polymorphisms and helicobacter pylori-related gastric cancer].
abstract: Helicobacter pylori-related gastric cancer is a special-type gastric cancer determined by genetic, environmental, and life style factors. A series of single nucleotide polymorphisms (SNPs) of susceptibility genes, including inflammation-related genes, gastric acid inhibition-related genes, and immune response-related genes, could be specifically involved in the development of Helicobacter pylori-related gastric cancer that consists of three major stages: Helicobacter pylori infection, gastric atrophy development, and carcinogenesis. The aim of the present paper was to review and evaluate the most recently published evidence on the contribution of SNPs to the carcinogenesis of Helicobacter pylori-related gastric cancer in humans.
authors.affiliation: Cancer Control Laboratory of Cancer Institute and General Surgery, Key Laboratory of Cancer Control in Liaoning Province, the First Affiliated Hospital of China Medical University, Shenyang 110001, China. hecaiyun851110@126.com
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: He
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D000818:Animals; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000235:genetics* / Q000382:microbiology; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology