title: Low-temperature sol-gel-derived nanosilver-embedded silane coating as biofilm inhibitor.
abstract: Silver nanocomposite coatings are prepared by the sol-gel method for the prevention of biofilm formation on the surface of medical implanted devices. High-temperature processing of such coatings can lead to diffusion of nanosilver and reduce the amount of available silver particles for long-term effects. Using a low-temperature sol-gel method, we have successfully prepared silane-based matrices, phenyltriethoxysilane (PhTEOS), containing different amounts of Ag nanoparticles. The incorporation of a silver salt into the sol-gel matrix resulted in a desired silver release rate, i.e. high initial release rate followed by a lower sustained release for more than 15 days, as determined by inductively coupled plasma mass spectrometry (ICP-MS). Scanning electron microscopy (SEM) has been employed to investigate the morphology of the film surfaces before and after immersion in a nutrient-rich bacterial suspension of approximately 10⁸ CFU ml⁻¹, which was incubated for up to 30 days at 37 °C. It was found that thin films containing 35 nm particles could prevent the formation of biofilm for over 30 days. The presence of surface silver before and after 3, 9 and 15 days immersion was confirmed by x-ray photoelectron spectroscopy (XPS).
authors.affiliation: Department of Physics and Laboratory of Sono-and Photo-theranostic Technologies, Harbin Institute of Technology, Harbin 150080, People's Republic of China.
authors.forename: A
authors.initials: A
authors.lastname: Babapour
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: S
authors.initials: S
authors.lastname: Bahang
authors.forename: W
authors.initials: W
authors.lastname: Cao
mesh_terms: D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D001682:Biological Availability; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005782:Gels / Q000737:chemistry; D006358:Hot Temperature; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D056951:Photoelectron Spectroscopy; D012821:Silanes / Q000737:chemistry*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D012835:Silver Nitrate / Q000737:chemistry; D013499:Surface Properties; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D012821:Silanes; D012834:Silver; D012835:Silver Nitrate; C538884:phenyltriethoxysilane