title: Concomitant unilateral and synchronous bilateral testis cancer in azoospermic dizygotic twins: differential management of fertility preservation.
abstract: OBJECTIVE
  To optimize fertility preservation management in unilateral or bilateral testicular cancer.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Urology department and reproductive biology laboratory.
  
  
  METHODS
  Dizygotic azoospermic twins presenting unilateral and bilateral synchronous testicular tumors.
  
  
  METHODS
  Testicular sperm extraction (TESE) and orchiectomy.
  
  
  METHODS
  Semen analysis, histologic diagnosis.
  
  
  RESULTS
  No spermatozoa were cryopreserved for the first case, because fertility preservation was proposed after orchiectomy. Spermatozoa were retrieved after TESE for his brother with bilateral tumor.
  
  
  CONCLUSIONS
  Clinicians should be aware of the need to recommend sperm banking before treatments may alter spermatogenesis. TESE may be the sole option for fertility preservation in bilateral testicular cancer.
authors.affiliation: Service d'Urologie, Spermatogenèse et qualité du gamète mâle, Hôpital Charles Nicolle, Rouen, France. athmane.safsaf@gmail.com
authors.forename: Athmane
authors.initials: A
authors.lastname: Safsaf
authors.forename: Louis
authors.initials: L
authors.lastname: Sibert
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Cleret
authors.forename: Anne
authors.initials: A
authors.lastname: Perdrix
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Milazzo
authors.forename: Françoise
authors.initials: F
authors.lastname: Gobet
authors.forename: Bertrand
authors.initials: B
authors.lastname: Mace
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rives
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D015925:Cryopreservation; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D009919:Orchiectomy / Q000009:adverse effects*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D013074:Sperm Banks; D053625:Sperm Retrieval; D013091:Spermatogenesis / Q000187:drug effects / Q000528:radiation effects; D013736:Testicular Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome; D014429:Twins, Dizygotic / Q000235:genetics*