title: Determination of nitrosamines in water by gas chromatography/chemical ionization/selective ion trapping mass spectrometry.
abstract: A gas chromatography/mass spectrometry (GC/MS) method for determination of nine N-nitrosamines (NAs) in water is described. Two ionization modes, electron impact (EI) and chemical ionization (CI) with methanol, as well as different ion analysis techniques, i.e. full scan, selected ion storage (SIS) and tandem mass spectrometry (MS/MS) were tested. Chemical ionization followed by SIS resulted the mass spectrometric method of choice, with detection limits in the range of 1-2ng/L. Solid Phase Extraction (SPE) with coconut charcoal cartridges was applied to extract NAs from real samples, according EPA Method 521. Drinking water samples were collected from seven surface- and two groundwater treatment plants. Three surface water treatment plants were sampled before and after addition of O(3)/ClO(2) to observe the effect of disinfection on NAs' formation. N-nitrosodiethylamine (NDEA), n-nitrosodipropylamine (NDPA), n-nitrosomorpholine (NMOR) and n-nitrosodibutylamine (NDBA) were found up to concentrations exceeding three times the risk level of 10ng/L set by the California Department of Public Health. Because dermal adsorption has been recently indicated as a new contamination route of exposure to NAs for people who practice swimming activity, water samples from five swimming pools in the Bologna (Italy) area were collected. N-nitrosopyrrolidine (NPYR) was detected in all samples at concentrations larger than 50ng/L, likely as a disinfection by-product from the amino acid precursor proline, a main constituent of skin collagen.
authors.affiliation: Department of Chemistry "G. Ciamician", University of Bologna, via F. Selmi 2, I-40126 Bologna, Italy. romina.pozzi4@unibo.it
authors.forename: Romina
authors.initials: R
authors.lastname: Pozzi
authors.forename: Paola
authors.initials: P
authors.lastname: Bocchini
authors.forename: Francesca
authors.initials: F
authors.lastname: Pinelli
authors.forename: Guido C
authors.initials: GC
authors.lastname: Galletti
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D007558:Italy; D009602:Nitrosamines / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D052616:Solid Phase Extraction; D013551:Swimming Pools; D014874:Water Pollutants, Chemical / Q000032:analysis*; D014881:Water Supply / Q000032:analysis
chemical_list: D009602:Nitrosamines; D014874:Water Pollutants, Chemical