title: Aseptic meningitis in association with glyphosate-surfactant herbicide poisoning.
abstract: BACKGROUND
  The mechanisms underlying early central nervous system (CNS) signs and symptoms of glyphosate-surfactant herbicide (GlySH) poisoning are unclear.
  
  
  METHODS
  A 58-year-old woman ingested approximately 150 mL of GlySH containing 41% glyphosate and 15% polyoxyethyleneamine. Two days later, she was admitted in the Emergency Center in a semicomatose state. Acute respiratory distress syndrome, circulatory collapse, acute renal failure, and disseminated intravascular coagulopathy were diagnosed. Meningitis was also suspected as she demonstrated Kernig's sign and significant neck stiffness with rigidity of the extremities as well as consciousness disturbance and fever (38.4°C). Investigations of cerebrospinal fluid (CSF) revealed the presence of glyphosate (122.5 μg/mL), significant elevation of IL-6 (394 μg/mL), and pleocytosis (32 cells/μL) with monocyte dominance. All bacteriological and virological tests were later found to be negative. She recovered completely after responding to aggressive supportive care in the intensive care unit. All signs and symptoms suggesting meningitis resolved as the concentration of glyphosate in CSF decreased. She was discharged on day 39 of hospitalization.
  
  
  CONCLUSIONS
  These findings suggest that the present case involved aseptic meningitis in association with GlySH poisoning.
  
  
  CONCLUSIONS
  CNS signs and symptoms induced by aseptic meningitis should be considered in cases of glyphosate-surfactant herbicide poisoning.
authors.affiliation: Department of Emergency and Critical Care Medicine, School of Medicine, Kitasato University, Minamiku, Sagamihara, 252-0374, Japan. satochie12@tenor.ocn.ne.jp
authors.forename: Chie
authors.initials: C
authors.lastname: Sato
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kamijo
authors.forename: Kuniko
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Ide
mesh_terms: D004338:Drug Combinations; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid / Q000506:poisoning; D006540:Herbicides / Q000134:cerebrospinal fluid / Q000506:poisoning*; D006801:Humans; D008582:Meningitis, Aseptic / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D008875:Middle Aged; D011041:Poisoning / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D011092:Polyethylene Glycols / Q000506:poisoning*; D013501:Surface-Active Agents / Q000506:poisoning*; D016896:Treatment Outcome; D000097797:Glyphosate
chemical_list: D004338:Drug Combinations; D005998:Glycine; D006540:Herbicides; D011092:Polyethylene Glycols; D013501:Surface-Active Agents; D000097797:Glyphosate; C054694:polyoxyethyleneamine