title: Chemical surface alteration of biodegradable magnesium exposed to corrosion media.
abstract: The understanding of corrosion processes of metal implants in the human body is a key problem in modern biomaterial science. Because of the complicated and adjustable in vivo environment, in vitro experiments require the analysis of various physiological corrosion media to elucidate the underlying mechanism of "biological" metal surface modification. In this paper magnesium samples were incubated under cell culture conditions (i.e. including CO(2)) in electrolyte solutions and cell growth media, with and without proteins. Chemical mapping by high-resolution electron-induced X-ray emission spectroscopy and infrared reflection microspectroscopy revealed a complex structure of the formed corrosion layer. The presence of CO(2) in concentrations close to that in blood is significant for the chemistry of the oxidised layer. The presence of proteins leads to a less dense but thicker passivation layer which is still ion and water permeable, as osmolality and weight measurements indicate.
authors.affiliation: Helmholtz-Zentrum Geesthacht, Institute for Materials Research, Max-Planck-Str. 1, 21502 Geesthacht, Germany. regine.willumeit@hzg.de
authors.forename: Regine
authors.initials: R
authors.lastname: Willumeit
authors.forename: Janine
authors.initials: J
authors.lastname: Fischer
authors.forename: Frank
authors.initials: F
authors.lastname: Feyerabend
authors.forename: Norbert
authors.initials: N
authors.lastname: Hort
authors.forename: Ulrich
authors.initials: U
authors.lastname: Bismayer
authors.forename: Stefanie
authors.initials: S
authors.lastname: Heidrich
authors.forename: Boriana
authors.initials: B
authors.lastname: Mihailova
mesh_terms: D008274:Magnesium / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D008274:Magnesium