title: Severe human parechovirus sepsis beyond the neonatal period.
abstract: Here we describe a case of viral sepsis beyond the neonatal period caused by human parechovirus subtype 3 (HPeV-3), which manifested as cardio-respiratory failure, hepatitis, and necrotizing enterocolitis (NEC). HPeV-1 and 2 were originally classified as enteroviruses but the advent of sequence analysis led to them being recognized as a new genus in the picornavirus family. Subsequently, nine additional HPeV strains have been reported including HPeV-3 in 1999.(1) The spectrum of disease that these viruses may cause is still unknown, and they are rarely screened for in clinical practice.
authors.affiliation: Tripler Army Medical Center, Department of Pediatrics, ATTN: MCHK-PE, 1 Jarrett White Road, Honolulu, HI 96859, United States. rebecca.sainato@us.army.mil
authors.forename: Rebecca
authors.initials: R
authors.lastname: Sainato
authors.forename: Ryan
authors.initials: R
authors.lastname: Flanagan
authors.forename: Steven
authors.initials: S
authors.lastname: Mahlen
authors.forename: Mary
authors.initials: M
authors.lastname: Fairchok
authors.forename: Loranee
authors.initials: L
authors.lastname: Braun
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000209:etiology; D002443:Ceftriaxone / Q000627:therapeutic use; D020345:Enterocolitis, Necrotizing / Q000209:etiology; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005334:Fever; D006333:Heart Failure / Q000209:etiology; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D030061:Parechovirus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D010850:Picornaviridae Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010878:Piperacillin / Q000627:therapeutic use; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics; D012131:Respiratory Insufficiency / Q000209:etiology; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D018805:Sepsis / Q000175:diagnosis* / Q000209:etiology; D017423:Sequence Analysis, RNA; D000078142:Tazobactam
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D012367:RNA, Viral; D002443:Ceftriaxone; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin