title: [Pathomechanism of vitamin D intoxication].
abstract: Pathomechanism of vitamin D intoxication is still unclear. Experiments on animals showed that intoxication is accompanied by distinctly elevated serum level of vitamin D precursor [25(OH)D3] but not by that of hormonally, metabolic active form of it [1alpha,25(OH)2D3]. The most probable explanation of this phenomenon is that vitamin D precursor releases hormonal form of vitamin from its binding with serum transporting protein (DBP) stimulating in this way transcription of genes in cells of target tissues.
authors.affiliation: Zakład Biochemii i Fizjologii Klinicznej Gdańskiego Uniwersytetu Medycznego, Gdańsk.
authors.forename: Iwona
authors.initials: I
authors.lastname: Rybakowska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Klimek
authors.forename: Krystian
authors.initials: K
authors.lastname: Kaletha
authors.forename: Jacek
authors.initials: J
authors.lastname: Sein Anand
mesh_terms: D000818:Animals; D006801:Humans; D014807:Vitamin D / Q000097:blood* / Q000506:poisoning*
chemical_list: D014807:Vitamin D