title: Luminescent, mesoporous, and bioactive europium-doped calcium silicate (MCS: Eu3+) as a drug carrier.
abstract: Luminescent, mesoporous, and bioactive europium-doped calcium silicate (MCS: Eu) was successfully synthesized. The obtained MCS: Eu(3+) was performed as a drug delivery carrier to investigate the drug storage/release properties using ibuprofen (IBU) as the model drug. The structural, morphological, textural, and optical properties were well characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), N(2) adsorption/desorption, and photoluminescence (PL) spectra, respectively. The results reveal that the MCS: Eu exhibits the typical ordered characteristics of the mesostructure. This composite shows a sustained release profile with IBU as the model drug. The IBU-loaded samples still present red luminescence of Eu(3+) ((5)D(0)-(7)F(1,2)) under UV irradiation. The emission intensities of Eu(3+) in the drug carrier system vary with the amount of released IBU, making the drug release easily tracked and monitored. The system demonstrates a great potential for drug delivery and disease therapy.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Fan
authors.forename: Shanshan
authors.initials: S
authors.lastname: Huang
authors.forename: Jinhua
authors.initials: J
authors.lastname: Jiang
authors.forename: Guogang
authors.initials: G
authors.lastname: Li
authors.forename: Piaoping
authors.initials: P
authors.lastname: Yang
authors.forename: Hongzhou
authors.initials: H
authors.lastname: Lian
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D002118:Calcium / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry; D049449:Luminescence; D046529:Microscopy, Electron, Transmission; D016062:Porosity; D017640:Silicates / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D017640:Silicates; D005063:Europium; D002118:Calcium; D007052:Ibuprofen