title: Synthesis of protected lactam-bridged dipeptides.
abstract: Lactam-bridged dipeptides are useful tools for the introduction of conformational constraint in higher peptides. General methods have been devised for the synthesis of dipeptides having five-, six-, and seven-membered ring constraints (1,2). This chapter will focus on four synthetic paths from protected chiral a-amino acids to lactams that involve intramolecular alkylation, intermolecular alkylation, intramolecular acylation, and condensation with formaldehyde for a one carbon unit insertion.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA.
authors.forename: D S
authors.initials: DS
authors.lastname: Perlow
authors.forename: R M
authors.initials: RM
authors.lastname: Freidinger