title: Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice.
abstract: Those mice whose skin-derived primary fibroblast cell lines resist lethal injury induced by hydrogen peroxide or UV light show lower age-related decline in hearing. Skin cell lines may provide an easily accessible surrogate index of intrinsic stress resistance that varies among individuals and influences the pace of neurosensory decline in aging mice.
authors.affiliation: Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. millerr@umich.edu
authors.forename: Richard A
authors.initials: RA
authors.lastname: Miller
authors.forename: David
authors.initials: D
authors.lastname: Dolan
authors.forename: Melissa
authors.initials: M
authors.lastname: Han
authors.forename: William
authors.initials: W
authors.lastname: Kohler
authors.forename: Jochen
authors.initials: J
authors.lastname: Schacht
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D034381:Hearing Loss / Q000503:physiopathology*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D016877:Oxidants / Q000494:pharmacology*; D018384:Oxidative Stress; D012867:Skin / Q000166:cytology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D016877:Oxidants; D006861:Hydrogen Peroxide