title: Residue depletion of nitrovin in chicken after oral administration.
abstract: In this study, the residue depletion of nitrovin in chicken was studied after feeding the birds with dietary feeds containing 10 mg/kg of nitrovin for 7 consecutive days. Tissues (muscle, fat, kidney, and liver) and plasma were collected at different withdrawal periods and determined by a high-performance liquid chromatography-ultraviolet (HPLC-UV) method. The limit of detection for nitrovin in tissue and plasma samples was 0.1 ng/(g or mL), and the inter- and intrarecoveries from the blank fortified samples were in the range of 71.1-85.7%. At the withdrawal period of 0 days, the residue concentration of nitrovin in plasma was the highest (average of 84.98 ng/mL) compared to those in muscle, fat, liver, and kidney (average of 21.04, 61.18, 24.04, and 68.28 ng/g, respectively). At the withdrawal period of 28 days, the residue levels of nitrovin in muscle, fat, liver, and plasma were all higher than 1.0 ng/(g or mL) and the highest concentration was in liver (average of 5.8 ng/g). These data are in support of the ban of nitrovin as a feed additive in food-producing animals.
authors.affiliation: Animal Science and Technology, Agricultural University of Hebei, Baoding Hebei 071000, People's Republic of China.
authors.forename: Xiao Dong
authors.initials: XD
authors.lastname: Yan
authors.forename: Li Jing
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Jian Ping
authors.initials: JP
authors.lastname: Wang
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000821:Animal Feed; D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D002645:Chickens / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis; D005506:Food Contamination / Q000032:analysis*; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D009132:Muscles / Q000737:chemistry; D009610:Nitrovin / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000890:Anti-Infective Agents; D009610:Nitrovin