title: On model of angiogenesis and the mechanism in porous silk fibroin films.
abstract: The purpose of this paper is to explore the mechanism of the angiogenesis modes in the biomaterials implanted in vivo. By means of experimental observation and analysis of the capillary growing state in the porous silk fibroin film implanted into rats, we intended to develop a modeling expression on the growth mode of the capillaries in the biomaterials. Additionally, we proposed the response model of endothelial cells (ECs) resulting from vascular endothelial growth factor's concentrations at different stages after the implantation. With the implantation experiment, it was identified that angiogenesis developed in the way of capillary sprouting at the early stage of implantation and of intussusception at the late stage. Based on the response model of ECs, experimental results are explained.
authors.affiliation: College of Textile and Clothing Engineering, Soochow University, 178 Xiangmen-road, Suzhou, China. bailun@shinshu-u.ac.jp
authors.forename: Lun
authors.initials: L
authors.lastname: Bai
authors.forename: Dongping
authors.initials: D
authors.lastname: Wu
authors.forename: Janmei
authors.initials: J
authors.lastname: Xu
authors.forename: Huifeng
authors.initials: H
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Xie
authors.forename: Guoping
authors.initials: G
authors.lastname: Guan
authors.forename: Ziling
authors.initials: Z
authors.lastname: Sun
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Tan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D012831:Bombyx; D003593:Cytoplasm / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology; D005349:Fibroins / Q000378:metabolism*; D008297:Male; D008855:Microscopy, Electron, Scanning / Q000379:methods; D046529:Microscopy, Electron, Transmission / Q000379:methods; D009389:Neovascularization, Pathologic; D016062:Porosity; D051381:Rats; D017207:Rats, Sprague-Dawley; D047011:Silk / Q000378:metabolism*; D013499:Surface Properties; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D047011:Silk; D042461:Vascular Endothelial Growth Factor A; D005349:Fibroins