title: Induced cross-linking reactions to target genes using modified oligonucleotides.
abstract: Synthetic oligonucleotides (ONs) are valuable tools that interfere with gene expression by specifically binding to target genes in a sequence-specific manner. Reactive ONs containing cross-linking agents are expected to induce efficient inhibition because they bind covalently to target genes. In recent years, researchers have reported several cross-linking reactions that target DNA induced by external stimuli. This short review highlights recently developed novel cross-linking reactions, focusing particularly on nucleoside derivatives developed by our group.
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi 980-8577, Japan. nagatugi@tagen.tohoku.ac.jp
authors.forename: Fumi
authors.initials: F
authors.lastname: Nagatsugi
authors.forename: Shuhei
authors.initials: S
authors.lastname: Imoto
mesh_terms: D003432:Cross-Linking Reagents / Q000737:chemistry*; D015870:Gene Expression; D006860:Hydrogen Bonding; D009841:Oligonucleotides / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D003432:Cross-Linking Reagents; D009841:Oligonucleotides