title: Urodynamics in women from menopause to oldest age: what motive? What diagnosis?
abstract: OBJECTIVE
  To analyze age-associated changes as a motive for urodynamics and urodynamic diagnosis in community-dwelling menopausal women and to discuss the role of menopause and ageing.
  
  
  METHODS
  Four hundred and forty nine consecutive menopausal women referred for urodynamic evaluation of lower urinary tract (LUT) symptoms, met the inclusion criteria and were stratified into 3 age groups: 55-64 years (A), 65-74 years (B), and 75-93 years (C). Comprehensive assessment included previous medical history and clinical examination. Studied items were motive for urodynamics, results of uroflows (free flow and intubated flow) and cystometry, urethral pressure profilometry, and final urodynamic diagnosis.
  
  
  RESULTS
  The main motive was incontinence (66.3%) with significant increase of mixed incontinence in group C (p = 0.028). Detrusor function significantly deteriorated in the oldest group, mainly in absence of neurological disease (overactivity p = 0.019; impaired contractility p = 0.028). In the entire population, underactivity predominated in group C (p = 0.0024). A progressive decrease of maximum urethral closure pressure occurred with ageing. In subjects with no detrusor overactivity there was a decrease with age of detrusor pressure at opening and at maximum flow, and of maximum flow while post void residual increased only in the C group.
  
  
  CONCLUSIONS
  In our population of community-dwelling menopausal women, incontinence was the main motive for urodynamics increasing with ageing. A brisk change in LUT function of women older than 75 years underlined deterioration in bladder function with a high incidence of detrusor hyperactivity with or without impaired contractility while change in urethral function was progressive. Effect of ageing appears to be predominant compared to menopause.
authors.affiliation: Universite Pierre et Marie Curie, Paris, France. favalentini@gmail.com
authors.forename: Françoise A
authors.initials: FA
authors.lastname: Valentini
authors.forename: Gilberte
authors.initials: G
authors.lastname: Robain
authors.forename: Brigitte G
authors.initials: BG
authors.lastname: Marti
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000175:diagnosis / Q000503:physiopathology*; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D012107:Research Design; D018709:Statistics, Nonparametric; D001743:Urinary Bladder / Q000503:physiopathology; D014563:Urodynamics / Q000502:physiology*