title: Cerebrosides and 2-pyridone alkaloids from the halotolerant fungus Penicillium chrysogenum grown in a hypersaline medium.
abstract: Five new cerebrosides, chrysogesides A-E (1-5), and two new 2-pyridone alkaloids, chrysogedones A and B (6 and 7), were isolated from the fermentation broth of Penicillium chrysogenum PXP-55, a halotolerant fungus grown in a hypersaline medium. Among them, chrysogesides B-D (2-4) are the first cerebrosides that contain an unsaturated C(19)-fatty acid. Their structures were identified by spectroscopic and chemical methods, including CD spectroscopy as well as the modified Mosher's method. Compound 2 showed antimicrobial activity against Enterobacter aerogenes with an MIC value of 1.72 μM.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Peng
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Kunlai
authors.initials: K
authors.lastname: Sun
authors.forename: Peipei
authors.initials: P
authors.lastname: Liu
authors.forename: Xia
authors.initials: X
authors.lastname: Yin
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021902:Enterobacter aerogenes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010408:Penicillium chrysogenum / Q000737:chemistry*; D054712:Salinity
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D002554:Cerebrosides