title: Disease progression in pediatric multiple sclerosis: disparities between physical and neurocognitive outcomes.
abstract: Growing information regarding the neurocognitive burden of pediatric multiple sclerosis (MS) has become available in recent years. Whereas natural history studies suggest a longer time to irreversible disability in the pediatric population with MS than in the adult MS population, increasing knowledge suggests a relatively rapid accrual of cognitive deficits in this young population. This article will explore this paradox, taking into account studies that have focused on neuroimaging, cognition and outcomes in pediatric MS.
authors.affiliation: Pediatric MS and Demyelinating Disorders Center of the Jacobs Neurological Institute, Women and Children's Hospital of Buffalo, Buffalo, NY 14222, USA. ann.yeh@sympatico.ca
authors.forename: Eluen Ann
authors.initials: EA
authors.lastname: Yeh
authors.forename: Joy B
authors.initials: JB
authors.lastname: Parrish
authors.forename: Bianca
authors.initials: B
authors.lastname: Weinstock-Guttman
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D003071:Cognition; D003072:Cognition Disorders / Q000150:complications / Q000453:epidemiology / Q000473:pathology / Q000523:psychology*; D006233:Persons with Disabilities; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000150:complications / Q000453:epidemiology / Q000473:pathology / Q000523:psychology*; D009483:Neuropsychological Tests; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult