title: Comparative aspects of subplate zone studied with gene expression in sauropsids and mammals.
abstract: There is currently a debate about the evolutionary origin of the earliest generated cortical preplate neurons and their derivatives (subplate and marginal zone). We examined the subplate with murine markers including nuclear receptor related 1 (Nurr1), monooxygenase Dbh-like 1 (Moxd1), transmembrane protein 163 (Tmem163), and connective tissue growth factor (Ctgf) in developing and adult turtle, chick, opossum, mouse, and rat. Whereas some of these are expressed in dorsal pallium in all species studied (Nurr1, Ctgf, and Tmem163), we observed that the closely related mouse and rat differed in the expression patterns of several others (Dopa decarboxylase, Moxd1, and thyrotropin-releasing hormone). The expression of Ctgf, Moxd1, and Nurr1 in the oppossum suggests a more dispersed subplate population in this marsupial compared with mice and rats. In embryonic and adult chick brains, our selected subplate markers are primarily expressed in the hyperpallium and in the turtle in the main cell dense layer of the dorsal cortex. These observations suggest that some neurons that express these selected markers were present in the common ancestor of sauropsids and mammals.
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.
authors.forename: Wei Zhi
authors.initials: WZ
authors.lastname: Wang
authors.forename: Franziska M
authors.initials: FM
authors.lastname: Oeschger
authors.forename: Juan F
authors.initials: JF
authors.lastname: Montiel
authors.forename: Fernando
authors.initials: F
authors.lastname: García-Moreno
authors.forename: Anna
authors.initials: A
authors.lastname: Hoerder-Suabedissen
authors.forename: Leah
authors.initials: L
authors.lastname: Krubitzer
authors.forename: Carl Joakim
authors.initials: CJ
authors.lastname: Ek
authors.forename: Norman R
authors.initials: NR
authors.lastname: Saunders
authors.forename: Kerstin
authors.initials: K
authors.lastname: Reim
authors.forename: Aldo
authors.initials: A
authors.lastname: Villalón
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Molnár
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000254:growth & development / Q000378:metabolism*; D002642:Chick Embryo; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009893:Opossums; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D014426:Turtles