title: Topiramate diminishes fear memory consolidation and extinguishes conditioned fear in rats.
abstract: BACKGROUND
  Topiramate has been recognized as a drug that can induce memory and cognitive impairment. Using the one-trial inhibitory avoidance task, we sought to verify the effect of topiramate on consolidation and extinction of aversive memory. Our hypothesis was that topiramate inhibits the consolidation and enhances the extinction of this fear memory.
  
  
  METHODS
  In experiment 1, which occured immediately or 3 hours after training, topiramate was administered to rats, and consolidation of memory was verified 18 days after the conditioning session. In experiment 2, which occured 18-22 days after the training session, rats were submitted to the extinction protocol. Rats received topiramate 14 days before or during the extinction protocol.
  
  
  RESULTS
  Topiramate blocked fear memory retention (p < 0.01) and enhanced fear memory extinction (p < 0.001) only when administered during the extinction protocol.
  
  
  CONCLUSIONS
  This experimental design did not allow us to determine whether topiramate also blocked the reconsolidation of fear memory.
  
  
  CONCLUSIONS
  Topira mate diminishes fear memory consolidation and promotes extinction of inhibitory avoidance memory.
authors.affiliation: Centro de Memória, Instituto do Cérebro, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Laboratório de Neurociências, Instituto de Pesquisas Biomédicas, PUCRS, Porto Alegre, Brazil. paspl@uol.com.br
authors.forename: Pedro Antônio
authors.initials: PA
authors.lastname: Schmidt do Prado-Lima
authors.forename: Myriam Fortes
authors.initials: MF
authors.lastname: Perrenoud
authors.forename: Christian Haag
authors.initials: CH
authors.lastname: Kristensen
authors.forename: Martin
authors.initials: M
authors.lastname: Cammarota
authors.forename: Ivan
authors.initials: I
authors.lastname: Izquierdo
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects*; D005239:Fear / Q000187:drug effects*; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D000077236:Topiramate
chemical_list: D000077236:Topiramate; D005632:Fructose