title: Engineering Nanocarriers for siRNA Delivery.
abstract: The discovery of RNA interference has revitalized the long ongoing pursuit of gene therapy for the treatment of diseases. Nevertheless, despite promising results from experimental studies, there remains a pressing need for the development of nanocarriers that are clinically-relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add-ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery.
authors.affiliation: Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Shawn J
authors.initials: SJ
authors.lastname: Tan
authors.forename: Pichamon
authors.initials: P
authors.lastname: Kiatwuthinon
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Roh
authors.forename: Jason S
authors.initials: JS
authors.lastname: Kahn
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
mesh_terms: D015316:Genetic Therapy / Q000379:methods; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D034741:RNA, Small Interfering