title: Simultaneous dual-nuclei imaging for motion corrected detection and quantification of 19F imaging agents.
abstract: Fluorine MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or monitoring. Because non-proton MRI applications lack morphological information, accompanying proton images are needed to elucidate the spatial tissue context. Furthermore, low concentrations typical of targeted molecular imaging agents require long examinations for signal averaging during which physiological motion may lead to blurring, underestimation in signal quantification, and erroneous localization of the agent distribution. Novel methods for truly simultaneous acquisition of dual-nuclei MR data are presented that offer efficient and precise anatomical localization of fluorine signals using accurate motion correction based on contemporaneous proton signals. The feasibility of simultaneous dual-nuclei MRI motion correction and corresponding dual-resolution reconstruction, providing nuclei-specific spatial resolution to retrospectively optimize the balance between signal-to-noise ratio and resolution, is shown on a clinical 3 T MR system.
authors.affiliation: Philips Technologie GmbH, Innovative Technologies, Research Laboratories, Hamburg, Germany. jochen.keupp@philips.com
authors.forename: Jochen
authors.initials: J
authors.lastname: Keupp
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rahmer
authors.forename: Ingmar
authors.initials: I
authors.lastname: Grässlin
authors.forename: Peter C
authors.initials: PC
authors.lastname: Mazurkewitz
authors.forename: Tobias
authors.initials: T
authors.lastname: Schaeffter
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Lanza
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Wickline
authors.forename: Shelton D
authors.initials: SD
authors.lastname: Caruthers
mesh_terms: D000818:Animals; D003287:Contrast Media; D005461:Fluorine; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D009038:Motion; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; D005461:Fluorine