title: Single-Strand Conformation Polymorphism Mutation Analysis of the p53 Gene.
abstract: Single-strand conformation polymorphism (SSCP) is a rapid and convenient procedure by which differences in the base composition of short DNA strands may be detected (1, 2). A useful application of this is in the comparison of polymerase chain reaction (PCR) generated products from gene coding sequences of unknown or patient material with a known wild-type standard; where any deviation of the banding pattern produced by the former from that produced by the latter indicates a possible mutation within the sequence of that product.
authors.affiliation: LRF Department of Haematology and Oncology Institute of Child Health, University of London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Booth