title: Electrochemical determination of L-phenylalanine at polyaniline modified carbon electrode based on β-cyclodextrin incorporated carbon nanotube composite material and imprinted sol-gel film.
abstract: A sensitive and selective electrochemical sensor based on a polyaniline modified carbon electrode for the determination of L-phenylalanine has been proposed by utilizing β-cyclodextrin (β-CD) incorporated multi-walled carbon nanotube (MWNT) and imprinted sol-gel film. The electrochemical behavior of the sensor towards L-phenylalanine was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and amperometric i-t curve. The surface morphologies of layer-by-layer assembly electrodes were displayed by scanning electron microscope (SEM). The response mechanism of the imprinted sensor for L-phenylalanine was based on the inclusion interaction of β-CD and molecular recognition capacity of the imprinted film for L-phenylalanine. A linear calibration plot was obtained covering the concentration range from 5.0 × 10(-7) to 1.0 × 10(-4) mol L(-1) with a detection limit of 1.0 × 10(-9) mol L(-1). With excellent sensitivity, selectivity, stability, reproducibility and recovery, the electrochemical imprinted sensor was used to detect L-phenylalanine in blood plasma samples successfully.
authors.affiliation: College of Chemistry and Chemical Engineering, Jishou University, Hunan 416000, PR China.
authors.forename: Yu-fang
authors.initials: YF
authors.lastname: Hu
authors.forename: Zhao-hui
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Hua-bin
authors.initials: HB
authors.lastname: Zhang
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Luo
authors.forename: Shou-zhuo
authors.initials: SZ
authors.lastname: Yao
mesh_terms: D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D057230:Limit of Detection; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon; D010649:Phenylalanine / Q000097:blood*; D015203:Reproducibility of Results; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D047392:beta-Cyclodextrins; D010649:Phenylalanine; C031215:betadex