title: Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and PAI-1 plasma levels in young patients with ischemic stroke.
abstract: The 4G/5G polymorphism in the plasminogen activator inhibitor-1 (PAI-1) gene, has been associated with arterial disease. In this study, we investigated the association of IS in young patients with CRP and PAI-1 levels and frequency of insertion-deletion polymorphism of PAI-1 gene. The plasma levels of PAI-1 and CRP and the frequency of 4G/5G polymorphism were analyzed in 127 Brazilian young patients that presented IS and in 201 healthy and unrelated control subjects. The levels of CRP (P < 0.001) and PAI-1 (P < 0.001) were significantly higher in patients when compared with control group. Only PAI-1 plasma levels were independently associated with risk of IS (OR 3.40; 95% CI 1.49-7.74; P = 0.001) after adjustments for lifestyles covariates. The 4G/4G genotype was significantly more frequent among control subjects as compared to patients (OR 0.41; 95% CI 0.24-0.68; P < 0.001). Although increased PAI-1 plasma levels are associated with development of IS in Brazilian young patients, they are not influenced by the 4G/5G PAI-1 polymorphism.
authors.affiliation: Health Sciences Center, Federal University of São João Del Rei, Av. Sebastião Gonçalves Coelho, 400, Divinópolis, MG CEP 35501 296, Brazil. adriansabin@yahoo.com
authors.forename: Adriano
authors.initials: A
authors.lastname: de Paula Sabino
authors.forename: Daniel Dias
authors.initials: DD
authors.lastname: Ribeiro
authors.forename: Caroline Pereira
authors.initials: CP
authors.lastname: Domingueti
authors.forename: Mariana Silva
authors.initials: MS
authors.lastname: Dos Santos
authors.forename: Telma
authors.initials: T
authors.lastname: Gadelha
authors.forename: Luci Maria Santana
authors.initials: LM
authors.lastname: Dusse
authors.forename: Maria
authors.initials: M
authors.lastname: das Graças Carvalho
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Fernandes
mesh_terms: D000293:Adolescent; D000328:Adult; D002545:Brain Ischemia / Q000097:blood / Q000150:complications* / Q000235:genetics; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012044:Regression Analysis; D020521:Stroke / Q000097:blood / Q000150:complications* / Q000235:genetics; D055815:Young Adult
chemical_list: D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D002097:C-Reactive Protein