title: The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population.
abstract: The MTHFD1L gene SNP variant rs11754661 was found to increase the risk of Alzheimer's disease in a recent Whole Genome Association Study. We have carried out an independent study of this genetic variant in 2467 individuals from Spain. We found no evidence of association between the MTHFD1L marker and susceptibility to Alzheimer's disease in our sample.
authors.affiliation: Department of Structural Genomics, NeoCodex, Sevilla, Spain.
authors.forename: Reposo
authors.initials: R
authors.lastname: Ramírez-Lorca
authors.forename: Mercé
authors.initials: M
authors.lastname: Boada
authors.forename: Carmen
authors.initials: C
authors.lastname: Antúnez
authors.forename: Jesús
authors.initials: J
authors.lastname: López-Arrieta
authors.forename: Concha
authors.initials: C
authors.lastname: Moreno-Rey
authors.forename: Isabel
authors.initials: I
authors.lastname: Hernández
authors.forename: Juan
authors.initials: J
authors.lastname: Marín
authors.forename: Javier
authors.initials: J
authors.lastname: Gayán
authors.forename: Antonio
authors.initials: A
authors.lastname: González-Pérez
authors.forename: Montserrat
authors.initials: M
authors.lastname: Alegret
authors.forename: Lluis
authors.initials: L
authors.lastname: Tárraga
authors.forename: Luis M
authors.initials: LM
authors.lastname: Real
authors.forename: Agustín
authors.initials: A
authors.lastname: Ruiz
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D000619:Aminohydrolases / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005574:Formate-Tetrahydrofolate Ligase / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D008297:Male; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000235:genetics*; D009097:Multienzyme Complexes / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance / Q000379:methods; D013030:Spain / Q000453:epidemiology
chemical_list: D005819:Genetic Markers; D009097:Multienzyme Complexes; C021836:formyl-methenyl-methylenetetrahydrofolate synthetase; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D000619:Aminohydrolases; D005574:Formate-Tetrahydrofolate Ligase