title: The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the Arctic bryozoan Tegella cf. spitzbergensis.
abstract: The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2-4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1-4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line.
authors.affiliation: Norwegian College of Fishery Science, University of Tromsø, Breivika N-9037, Tromsø, Norway. margey.tadesse@uit.no
authors.forename: Margey
authors.initials: M
authors.lastname: Tadesse
authors.forename: Jioji N
authors.initials: JN
authors.lastname: Tabudravu
authors.forename: Marcel
authors.initials: M
authors.lastname: Jaspars
authors.forename: Morten B
authors.initials: MB
authors.lastname: Strøm
authors.forename: Espen
authors.initials: E
authors.lastname: Hansen
authors.forename: Jeanette H
authors.initials: JH
authors.lastname: Andersen
authors.forename: Per E
authors.initials: PE
authors.lastname: Kristiansen
authors.forename: Tor
authors.initials: T
authors.lastname: Haug
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D002013:Bryozoa / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D007211:Indoles; C559015:ent-eusynstyelamide B