title: Risk factors of pancreatic fistula after pancreaticoduodenectomy: a collective review.
abstract: Postoperative pancreatic fistula (POPF) is the most frequent complication after pancreaticoduodenectomy, results in increased morbidity and mortality, and adversely affects length of stay and costs. Reported rates of postoperative pancreatic fistula vary from 0 per cent up to more than 30 per cent. Plenty of randomized trails and meta-analysis were published to analyze the ideal procedure, technique of anastomosis, and perioperative management of patients undergoing pancreaticoduodenectomy; however, results are often discordant and clear evidence on the ideal management and surgical technique to reduce POPF rate is not yet provided. This collective review examined the current evidence about risk factors contributing to postoperative pancreatic fistula and delineates methods of diagnosis and treatment of this universally dreaded complication.
authors.affiliation: University ''Sapienza,'' II Faculty of Medicine, Hospital ''Sant'Andrea,'' Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ramacciato
authors.forename: Paolo
authors.initials: P
authors.lastname: Mercantini
authors.forename: Niccolò
authors.initials: N
authors.lastname: Petrucciani
authors.forename: Giuseppe R
authors.initials: GR
authors.lastname: Nigri
authors.forename: Andrea
authors.initials: A
authors.lastname: Kazemi
authors.forename: Mirko
authors.initials: M
authors.lastname: Muroni
authors.forename: Massimo
authors.initials: M
authors.lastname: Del Gaudio
authors.forename: Albert
authors.initials: A
authors.lastname: Balesh
authors.forename: Matteo
authors.initials: M
authors.lastname: Cescon
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cucchetti
authors.forename: Matteo
authors.initials: M
authors.lastname: Ravaioli
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D010185:Pancreatic Fistula / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D016577:Pancreaticoduodenectomy; D011183:Postoperative Complications; D012307:Risk Factors