title: Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior.
abstract: BACKGROUND
  Sleep homeostasis is characterized by a positive correlation between sleep length and intensity with the duration of the prior waking period. A causal role for brain-derived neurotrophic factor (BDNF) in sleep homeostasis has been suggested, but the underlying mechanisms remain unclear. Cortistatin, a neuropeptide expressed primarily in a subset of cortical GABAergic interneurons, is another molecule implicated in sleep homeostasis.
  
  
  RESULTS
  We confirmed that sleep deprivation leads to an increase in cortical cortistatin mRNA expression. Disruption of activity-dependent BDNF expression in a genetically modified mouse line impairs both baseline levels of cortistatin mRNA as well as its levels following sleep deprivation. Disruption of activity-dependent BDNF also leads to a decrease in sleep time during the active (dark) phase.
  
  
  CONCLUSIONS
  Our studies suggest that regulation of cortistatin-expressing interneurons by activity-dependent BDNF expression may contribute to regulation of sleep behavior.
authors.affiliation: Genes, Cognition and Psychosis Program (GCAP), National Institute of Mental Health (NIMH), Bethesda, MD 20892, USA.
authors.forename: Keri
authors.initials: K
authors.lastname: Martinowich
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Schloesser
authors.forename: Dennisse V
authors.initials: DV
authors.lastname: Jimenez
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Weinberger
authors.forename: Bai
authors.initials: B
authors.lastname: Lu
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D015415:Biomarkers / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology; D004597:Electroshock; D005786:Gene Expression Regulation; D007395:Interneurons / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000235:genetics / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D009479:Neuropeptides; D012333:RNA, Messenger; C099323:cortistatin; D005680:gamma-Aminobutyric Acid