title: Night-time use of rotigotine in advanced Parkinson's disease.
abstract: Transdermal rotigotine was used in six patients with advanced Parkinson's disease and sleep disorders (UPDRS part II item 12 score ≥ 2) receiving oral levodopa and diurnal apomorphine infusions. Transdermal rotigotine (2-4 mg/24h) was used at night for four months. Sleep disorders improved, the total Parkinson's Disease Sleep Scale score falling by an average of 45%; significant improvements emerged in the items quality of sleep and difficulty in remaining asleep (p<0.05). No undesirable dopaminergic effects were reported. This preliminary open-label study suggests that transdermal rotigotine may be a well tolerated and effective treatment in patients with advanced Parkinson's disease, reducing nocturnal disability and ameliorating sleep disorders without inducing undesirable dopaminergic effects.
authors.affiliation: parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy. canesi@parkinson.it
authors.forename: Margherita
authors.initials: M
authors.lastname: Canesi
authors.forename: Claudio B
authors.initials: CB
authors.lastname: Mariani
authors.forename: Ioannis U
authors.initials: IU
authors.lastname: Isaias
authors.forename: Gianni
authors.initials: G
authors.lastname: Pezzoli
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D001058:Apomorphine / Q000627:therapeutic use; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D010865:Pilot Projects; D012893:Sleep Wake Disorders / Q000150:complications / Q000188:drug therapy*; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D013876:Thiophenes / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018491:Dopamine Agonists; D013764:Tetrahydronaphthalenes; D013876:Thiophenes; D007980:Levodopa; C047508:rotigotine; D001058:Apomorphine