title: [Brain SPECT in Lewy body dementia].
abstract: Dementia of Lewy bodies (DLB) is the second cause of degenerative dementia. There is many clinical presentation of the disease. Brain single photon computed tomography (SPECT) is a simple way to investigate routinely the cerebral blood flow. On cerebral perfusion SPECT, DLB is accompanied by diffuse cortical hypoperfusion predominantly at the posterior cortex and may affect the associative and primary visual areas in relation to neuronal loss or dysfunction. DLB patients have striatal hypofixation on cerebral neurotranmission SPECT-DaTSCAN(®), related with dopaminergic loss. Brain SPECT is useful in the differential diagnosis between DLB and other dementia.
authors.affiliation: AP-HP, hôpital Hôtel-Dieu de Paris, service de médecine nucléaire, 75004 Paris, France. kwfarid@hotmail.com
authors.forename: Karim
authors.initials: K
authors.lastname: Farid
authors.forename: Lisette
authors.initials: L
authors.lastname: Volpe-Gillot
authors.forename: Nadine
authors.initials: N
authors.lastname: Caillat-Vigneron
mesh_terms: D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000000981:diagnostic imaging*; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D002800:Cholinesterase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D000075202:Contraindications; D003287:Contrast Media; D003342:Corpus Striatum / Q000098:blood supply / Q000000981:diagnostic imaging; D003704:Dementia / Q000175:diagnosis; D003937:Diagnosis, Differential; D004298:Dopamine / Q000032:analysis; D006801:Humans; D020961:Lewy Body Disease / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009474:Neurons / Q000737:chemistry / Q000473:pathology; D055420:Perfusion Imaging / Q000379:methods; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D014150:Antipsychotic Agents; D015415:Biomarkers; D002800:Cholinesterase Inhibitors; D003287:Contrast Media; C054369:MAPT protein, human; D016875:tau Proteins; D004298:Dopamine