title: Yin Yang-1(YY-1) expression in idiopathic pulmonary fibrosis.
abstract: BACKGROUND
  Yin Yang-1 (YY-1) is implicated in the pathogenesis of lung cancer which can be complicated with idiopathic pulmonary fibrosis (IPF).
  
  
  OBJECTIVE
  The aim of the study was to investigate whether YY-1 is involved in the pathogenesis of IPF and whether represents a common pathogenetic pathway which could explain the coexistence of these disorders.
  
  
  METHODS
  Lung tissue from 52 patients (37 with IPF and 15 controls) and bronchoalveolar lavage fluid (BALF) from 34 patients (25 with IPF and 9 controls) were studied and YY-1 mRNA expression was evaluated by real-time PCR.
  
  
  RESULTS
  YY-1 was expressed in 8% (3/37) of IPF patients and in 6% (1/15) of healthy controls in tissue samples. In addition, 12% (3/25) of IPF patients and 33% (3/9) of healthy controls have expressed YY-1 gene in BALF samples. However, no statistical significant difference in mRNA expression between patients and controls has been detected in both tissue and BAL fluid samples.
  
  
  CONCLUSIONS
  Our results do not support the hypothesis of YY-1 involvement in IPF. However, similar expression of YY-1 gene in two biological samples cannot exclude a possible role of this polymorphic gene in the pathway of IPF. Further studies in a larger scale of patients are needed.
authors.affiliation: Interstitial Lung Disease Unit, Department of Thoracic Medicine, University Hospital of Heraklion, Crete, Greece.
authors.forename: Giorgos A
authors.initials: GA
authors.lastname: Margaritopoulos
authors.forename: Katerina M
authors.initials: KM
authors.lastname: Antoniou
authors.forename: Giannoula
authors.initials: G
authors.lastname: Soufla
authors.forename: Evi
authors.initials: E
authors.lastname: Vassalou
authors.forename: Demetrios A
authors.initials: DA
authors.lastname: Spandidos
authors.forename: Nikos M
authors.initials: NM
authors.lastname: Siafakas
mesh_terms: D001992:Bronchoalveolar Lavage Fluid; D016022:Case-Control Studies; D005786:Gene Expression Regulation; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000378:metabolism*; D050986:YY1 Transcription Factor / Q000235:genetics / Q000378:metabolism*
chemical_list: D050986:YY1 Transcription Factor; C494698:YY1 protein, human