title: Novel ferrocenyl nitroxide nanoparticles as electron paramagnetic resonance oximetry probes in vitro and in vivo.
abstract: OBJECTIVE
  In this article we report our recent developments in the field of electron paramagnetic resonance oximetry.
  
  
  METHODS
  Novel synthesized ferrocenyl nitroxide radicals (FcN)-1-6 were evaluated to determine their electron paramagnetic resonance oxygen responsiveness and reduction resistance. The 3-ferrocenyl-N-(oxyl-2,2,6,6-tetramethylpiperidin-4-yl) butanamide radical (FcN-6), with outstanding electron paramagnetic resonance oxygen sensitivity, was encapsulated in Pluronic F-127 polymeric nanoparticles.
  
  
  RESULTS
  The nanoparticles exhibited good oxygen sensitivity, long-term stability of responsiveness, targeting to lung, liver and tumor, and low toxicity.
  
  
  CONCLUSIONS
  These features make this novel nanoparticle especially valuable for mapping O₂ concentrations in the body and monitoring the oxygen level inside tissues.
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis & Test, East China University of Science & Technology, Shanghai 200237, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Qiu
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhao
authors.forename: Ronghua
authors.initials: R
authors.lastname: Yu
authors.forename: Jiufeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Minbo
authors.initials: M
authors.lastname: Lan
mesh_terms: D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000175:diagnosis; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005260:Female; D005296:Ferrous Compounds / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D053758:Nanoparticles / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry*; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000032:analysis*; D020442:Poloxamer / Q000737:chemistry; D012680:Sensitivity and Specificity
chemical_list: D005296:Ferrous Compounds; D009589:Nitrogen Oxides; D020442:Poloxamer; C039900:nitroxyl; D010100:Oxygen