title: [Neuroprotective effect of low-molecular peptide mimetic (GK-2) of nerve growth factor is related to activated synthesis of heat shock proteins (hsp32 and hsp70) and increased phosphorylation of TrkA receptor].
abstract: Experiments in vitro showed that dimeric linear substituted dipeptide GK-2-a new mimetic of the nerve growth factor (NGF) - introduced in a concentration of 10(-5) M and 10(-8) M in the culture of immortalized murine hippocampal cell line HT-22 increases the synthesis of heat shock proteins HSP32 and HSP70 (neuroprotectors belonging to the endogenous system of cell protection) and stimulates tyrosine phosphorylation of TrkA receptor, which is specific for neurotrophins.
authors.forename: T A
authors.initials: TA
authors.lastname: Antipova
mesh_terms: D000818:Animals; D002461:Cell Line, Transformed; D005786:Gene Expression Regulation / Q000187:drug effects; D050890:HSP30 Heat-Shock Proteins / Q000096:biosynthesis*; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006624:Hippocampus / Q000378:metabolism*; D051379:Mice; D020932:Nerve Growth Factor / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D057786:Peptidomimetics / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects; D020917:Receptor, trkA / Q000378:metabolism*
chemical_list: D050890:HSP30 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018696:Neuroprotective Agents; D057786:Peptidomimetics; D020932:Nerve Growth Factor; D020917:Receptor, trkA