title: Five different phenotypes of endothelial cell cultures from the bovine corpus luteum: present outcome and role of potential dendritic cells in luteolysis.
abstract: Progress in understanding the background of structural luteolysis depends on insights into the physiological function of innate immunity (INIM), in particular the presence of dendritic cells (DCs) in the corpus luteum (CL). For this reason, the cultures of five endothelial cell-like phenotypes derived from the bovine CL and their long-lasting analysis (morphology, function, and origin) become important. Types 1 and 2 represent microvascular endothelial cells with cytokeratin (CK) expression, assumed to be danger-sensing cells. Types 3 and 4 express features of common endothelial cells. Type 5 indicates a steroidogenic cell type, which could be derived from steroidogenic CK(+) cells in the CL of development after loss of CK expression. Type 5 is a promising candidate to become a mature DC. It might act with the microvascular CK(+) cell/type 1 like a luteovascular unit, which connects INIM with adaptive/cell-mediated immunity (ADIM) in structural luteolysis.
authors.affiliation: Institute of Anatomy, University of Leipzig, Leipzig, Germany. spanelb@medizin.uni-leipzig.de
authors.forename: Katharina
authors.initials: K
authors.lastname: Spanel-Borowski
mesh_terms: D000818:Animals; D002417:Cattle; D003338:Corpus Luteum / Q000098:blood supply / Q000166:cytology* / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D042783:Endothelial Cells / Q000276:immunology / Q000378:metabolism*; D005260:Female; D007113:Immunity, Innate; D007633:Keratins / Q000378:metabolism; D003341:Luteolysis / Q000235:genetics* / Q000276:immunology; D055806:Microvessels / Q000166:cytology / Q000276:immunology; D010641:Phenotype
chemical_list: D007633:Keratins