title: Controlling cell growth on titanium by surface functionalization of heptylamine using a novel combined plasma polymerization mode.
abstract: A novel bio-interface, produced by a combined plasma polymerization mode on a titanium (Ti) surface, was shown to enhance osteoblast growth and reduce fibroblast cell growth. This new method can securely attach a tailored interface to difficult materials such as Ti or ceramics. Here a more stable and higher density of NH₂ functional groups is able to withstand sterilization in ethanol. The biocompatibility, in terms of cell attachment and actin cytoskeleton development, was markedly improved in vitro, compared with untreated Ti surfaces and samples treated by other plasma modes. It gave a boosted (approximately six times higher) cellular response of osteoblasts in their initial adhesion stage. These factors should increase the formation of new bone around implants (reducing healing time), promoting osseointegration and thereby increasing implantation success rates.
authors.affiliation: Department of Implant, College of Stomatology, Jilin University, Changchun, China; CSIRO Materials Science and Engineering, PO Box 21, Belmont, Victoria 3216, Australia.
authors.forename: Jing H
authors.initials: JH
authors.lastname: Zhao
authors.forename: Wojtek P
authors.initials: WP
authors.lastname: Michalski
authors.forename: Catherine
authors.initials: C
authors.lastname: Williams
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Xu
authors.forename: Peter R
authors.initials: PR
authors.lastname: Lamb
authors.forename: Scott
authors.initials: S
authors.lastname: Jones
authors.forename: Yan M
authors.initials: YM
authors.lastname: Zhou
authors.forename: Xiujuan J
authors.initials: XJ
authors.lastname: Dai
mesh_terms: D000199:Actins / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation; D003599:Cytoskeleton / Q000737:chemistry; D005347:Fibroblasts / Q000166:cytology; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods; D016348:Osseointegration; D010006:Osteoblasts / Q000166:cytology; D058105:Polymerization; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D000199:Actins; D000588:Amines; D001672:Biocompatible Materials; D014025:Titanium; C065369:tuaminoheptane