title: Increasing drug resistance in extensively drug-resistant tuberculosis, South Africa.
abstract: We expanded second-line tuberculosis (TB) drug susceptibility testing for extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa. Of 19 patients with extensively drug-resistant TB identified during February 2008-April 2009, 13 (68%) had isolates resistant to all 8 drugs tested. This resistance leaves no effective treatment with available drugs in South Africa.
authors.affiliation: Tugela Ferry Care and Research Collaboration, Tugela Ferry, South Africa. saritashah2@gmail.com
authors.forename: N Sarita
authors.initials: NS
authors.lastname: Shah
authors.forename: Jessica
authors.initials: J
authors.lastname: Richardson
authors.forename: Prashini
authors.initials: P
authors.lastname: Moodley
authors.forename: Salona
authors.initials: S
authors.lastname: Moodley
authors.forename: Palav
authors.initials: P
authors.lastname: Babaria
authors.forename: Melissa
authors.initials: M
authors.lastname: Ramtahal
authors.forename: Scott K
authors.initials: SK
authors.lastname: Heysell
authors.forename: Xuan
authors.initials: X
authors.lastname: Li
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Moll
authors.forename: Gerald
authors.initials: G
authors.lastname: Friedland
authors.forename: A Willem
authors.initials: AW
authors.lastname: Sturm
authors.forename: Neel R
authors.initials: NR
authors.lastname: Gandhi
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D054908:Extensively Drug-Resistant Tuberculosis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D013019:South Africa / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents