title: [Immunopathogenesis of HIV infection].
abstract: Killing of CD4 lymphocytes and systemic immune suppression are the hallmarks of HIV infection. These milestones are produced by different mechanisms that draw a complex picture of AIDS immunopathogenesis. The role of the GALT system as a preferential target for HIV, chronic activation of the immune system and viral escape mechanisms are recent challenges that have changed our current view on the mechanisms leading to immune destruction and development of AIDS. In this article, the mechanisms of immune suppression, the evolution of immune response throughout the infection and the mechanisms of viral escape are analysed.
authors.affiliation: Unidad de Inmunopatología del Sida, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
authors.forename: José
authors.initials: J
authors.lastname: Alcamí
authors.forename: Mayte
authors.initials: M
authors.lastname: Coiras
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology; D017209:Apoptosis; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology*; D018450:Disease Progression; D006678:HIV / Q000276:immunology / Q000502:physiology; D015483:HIV Antibodies / Q000096:biosynthesis / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D054298:Human Immunodeficiency Virus Proteins / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D018928:Immunity, Mucosal; D016867:Immunocompromised Host; D007413:Intestinal Mucosa / Q000276:immunology; D008213:Lymphocyte Activation; D008954:Models, Biological; D014775:Virus Activation; D017735:Virus Latency; D018406:Virus Physiological Phenomena
chemical_list: D015483:HIV Antibodies; D054298:Human Immunodeficiency Virus Proteins