title: Comparable ten-year outcome in hemodialysis patients with hepatitis C virus and hepatitis B virus coinfection and single hepatitis B virus infection.
abstract: Hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection in comparison with single HBV infection causes more severe liver disease in nonuremic population. The long-term impact of HBV/HCV coinfection on severity of liver diseases and patient survival in hemodialysis patients is unclear. Forty-eight HBV-positive patients and 19 HBV/HCV-positive patients were followed up from February 1996 to September 2006. During 10-year follow-up, there was no difference in acute hepatitis episodes, abnormal serum alanine aminotransferase period, occurrence of cirrhosis and hepatocellular carcinoma, and patient survival between the two groups. The serum HBV DNA levels in HBV/HCV-positive patients were significantly lower than those in HBV-positive patients during the first 27-month follow-up. In conclusion, HCV infection suppresses the serum HBV DNA level in hemodialysis patients. Nevertheless, HBV/HCV coinfection in comparison with single HBV infection does not cause more severe liver diseases or reduce patient survival in hemodialysis patients during 10-year follow-up.
authors.affiliation: Department of Nephrology, Lin-Kou Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Cheng-Chia
authors.initials: CC
authors.lastname: Lee
authors.forename: I-Jung
authors.initials: IJ
authors.lastname: Li
authors.forename: Yung-Chang
authors.initials: YC
authors.lastname: Chen
authors.forename: Jen-Wei
authors.initials: JW
authors.lastname: Cheng
authors.forename: Hsin-Hsu
authors.initials: HH
authors.lastname: Wu
authors.forename: Cheng-Hao
authors.initials: CH
authors.lastname: Weng
authors.forename: Ji-Tseng
authors.initials: JT
authors.lastname: Fang
authors.forename: Ya-Chung
authors.initials: YC
authors.lastname: Tian
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D000956:Antigens, Viral / Q000097:blood / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000254:growth & development* / Q000276:immunology; D006515:Hepatitis B virus / Q000254:growth & development* / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000150:complications / Q000453:epidemiology / Q000401:mortality / Q000628:therapy* / Q000821:virology; D019698:Hepatitis C, Chronic / Q000150:complications / Q000453:epidemiology / Q000401:mortality / Q000628:therapy* / Q000821:virology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D015996:Survival Rate; D013624:Taiwan
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D000410:Alanine Transaminase