title: Synthesis of functionalized pyrroles via catalyst- and solvent-free sequential three-component enamine-azoene annulation.
abstract: A new and efficient synthesis of polysubstituted pyrroles by a sequential one-pot three-component reaction between primary aliphatic amines, active methylene compounds, and 1,2-diaza-1,3-dienes (DDs) is reported. The reactions were performed without catalyst and under solvent-free conditions with complete control of pathway selectivity. Notably, the ready availability of the starting materials and the high level of practicability of the reaction and work up make this approach an attractive complementary method for access to unknown polysubstituted pyrroles.
authors.affiliation: Istituto di Chimica Organica, Università degli Studi di Urbino Carlo Bo, Via I Maggetti 24, 61029 Urbino, Italy.
authors.forename: Orazio A
authors.initials: OA
authors.lastname: Attanasi
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Favi
authors.forename: Fabio
authors.initials: F
authors.lastname: Mantellini
authors.forename: Giada
authors.initials: G
authors.lastname: Moscatelli
authors.forename: Stefania
authors.initials: S
authors.lastname: Santeusanio