title: Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza.
abstract: Acute transverse myelitis (ATM) has been described as an uncommon complication of vaccinations and is rarely accompanied by inflammatory peripheral neuropathy. We report a case of a 77-year-old woman who developed ATM and acute motor axonal neuropathy (AMAN) following vaccinations against seasonal and 2009 A/H1N1 influenza. She manifested ophthalmoplegia, quadriparesis and sensory impairment. MR imaging showed a longitudinally-extensive spinal cord lesion, and nerve conduction study revealed motor axonal polyneuropathy. Despite prompt treatment, her symptoms poorly recovered. While concurrent ATM and AMAN may suggest the presence of a common antigen, their scarcity indicates the importance of other factors causing immunologic disruptions.
authors.affiliation: Department of Neurology, Yokohama City Minato Red Cross Hospital, Japan. nozomu@fsinet.or.jp
authors.forename: Nozomu
authors.initials: N
authors.lastname: Sato
authors.forename: Kosuke
authors.initials: K
authors.lastname: Watanabe
authors.forename: Kiyobumi
authors.initials: K
authors.lastname: Ohta
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D001369:Axons / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects* / Q000276:immunology*; D008279:Magnetic Resonance Imaging; D016472:Motor Neuron Disease / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D009046:Motor Neurons / Q000276:immunology; D009188:Myelitis, Transverse / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D011115:Polyneuropathies / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D007252:Influenza Vaccines