title: Anti-inflammatory effects of resveratrol and oligostilbenes from Vitis thunbergii var. taiwaniana against lipopolysaccharide-induced arthritis.
abstract: Vitis thunbergii Sieb. and Zucc. var. taiwaniana Lu is an endemic plant in Taiwan used as a dietary supplement for bone health. In this study, human chondrocytes were induced to produce COX-2, MMP-3, -13, and PGE(2) by LPS. An (18)F-FDG microPET imaging system was used to evaluate the anti-inflammatory arthritic effects in vivo. Six stilbenes, resveratrol (1), (+)-ε-viniferin (2), ampelopsin C (3), ampelopsin A (4), (-)-vitisin B (5), and (+)-vitisin A (6), were isolated from the stem part of V. thunbergii, which displayed the strongest PGE(2) inhibition. Among these compounds, 1 significantly decreased COX-2 activity, PGE(2), MMP-3, and -13 production in vitro, and (18)F-FDG uptake and serum PGE(2) in rabbits in vivo. Anti-inflammatory effects were enhanced through the combined usage of 1 and other oligostilbenes. Taken together, the synergistic effects of 1 and oligostilbenes resulted in stem part extracts with lower 1 content displaying the better anti-inflammatory arthritis effects.
authors.affiliation: School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
authors.forename: Kun-Teng
authors.initials: KT
authors.lastname: Wang
authors.forename: Lih-Geeng
authors.initials: LG
authors.lastname: Chen
authors.forename: Sung-Hui
authors.initials: SH
authors.lastname: Tseng
authors.forename: Jung-Shan
authors.initials: JS
authors.lastname: Huang
authors.forename: Ming-Shium
authors.initials: MS
authors.lastname: Hsieh
authors.forename: Ching-Chiung
authors.initials: CC
authors.lastname: Wang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D008070:Lipopolysaccharides / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D000077185:Resveratrol; D021241:Spectrometry, Mass, Electrospray Ionization; D013267:Stilbenes / Q000627:therapeutic use*; D027843:Vitis / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D013267:Stilbenes; D000077185:Resveratrol