title: Combined microwave and electron beam exposure facilities for medical studies and applications.
abstract: The paper presents two radiation exposure facilities (REFs) which permit separate and simultaneous irradiation with microwaves (MW) of 2.45 GHz and electron beams (EB) of 6.23 MeV for malignant melanoma (MM) cell investigations, in vitro (MW+EB-REF-vitro) and in vivo (MW+EB-REF-vivo). The REFs are specifically designed for the following medical studies: 1) The effects of separate and combined (successive and simultaneous) MW and EB irradiation on the B16F10 mouse--MM cell cultures without/with drugs incubation, 2) The effects of separate and combined MW and EB irradiation on human blood components irradiated in samples of integral blood from healthy donors and from donors with MM; 3) The effects of separate and combined MW and EB whole body irradiation on the C57 BL/6 mice bearing MM without/with drugs administration. Several representative results obtained by experiments with REFs in vitro and in vivo are discussed. The most important conclusion of the experimental results is that low dose-total body MW+EB irradiation combined with drugs administration could present a valuable potential for an advanced study in malignant melanoma therapy.
authors.affiliation: National Institute for Lasers, Plasma and Radiation Physics, Bucharest, Romania. diana.martin@inflpr.ro
authors.forename: Diana
authors.initials: D
authors.lastname: Martin
authors.forename: Sabin
authors.initials: S
authors.lastname: Cinca
authors.forename: Irina
authors.initials: I
authors.lastname: Margaritescu
authors.forename: Monica
authors.initials: M
authors.lastname: Neagu
authors.forename: Nicusor
authors.initials: N
authors.lastname: Iacob
authors.forename: Daniel
authors.initials: D
authors.lastname: Ighigeanu
authors.forename: Constantin
authors.initials: C
authors.lastname: Matei
authors.forename: Gabriela
authors.initials: G
authors.lastname: Craciun
authors.forename: Elena
authors.initials: E
authors.lastname: Manaila
authors.forename: Doru Aurel
authors.initials: DA
authors.lastname: Chirita
authors.forename: Mihaela
authors.initials: M
authors.lastname: Moisescu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy / Q000295:instrumentation; D004583:Electrons / Q000627:therapeutic use*; D005160:Facility Design and Construction; D006801:Humans; D066298:In Vitro Techniques; D008545:Melanoma / Q000097:blood / Q000532:radiotherapy / Q000628:therapy; D008546:Melanoma, Experimental / Q000532:radiotherapy / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D008872:Microwaves / Q000627:therapeutic use*