title: The sex bias in novelty preference of preadolescent mouse pups may require testicular Müllerian inhibiting substance.
abstract: Male mouse pups exhibit elevated preference for novelty relative to their sisters. The testes of pups secrete high levels of Müllerian inhibiting substance (MIS, anti-Müllerian hormone), with neurons being a target of this hormone. We report here that Mis(+/+) male pups exhibit novelty preference, but their Mis(-/-) brothers and Mis(+/+) sisters do not. This suggests that MIS is one of the determinants of "boy"-specific behavior.
authors.affiliation: Brain Health Research Centre, and the Department of Anatomy & Structural Biology, University of Otago, Dunedin, New Zealand.
authors.forename: Kirstie
authors.initials: K
authors.lastname: Morgan
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Meredith
authors.forename: J-Y Adora
authors.initials: JY
authors.lastname: Kuo
authors.forename: David K
authors.initials: DK
authors.lastname: Bilkey
authors.forename: Ian S
authors.initials: IS
authors.lastname: McLennan
mesh_terms: D000818:Animals; D054304:Anti-Mullerian Hormone / Q000235:genetics / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D012727:Sex Characteristics
chemical_list: D054304:Anti-Mullerian Hormone