title: [Comparative pharmacokinetics and relative bioavailability of magnesium-containing drugs].
abstract: Pharmacokinetics of magnesium ions after single peroral administration of Magnelis B6 and Magne B6 coated tablets (magnesium dose, 48 mg) was studied in rabbits. In the blood plasma, the level of magnesium ions was very low compared to the endogenous level, which did not allow the drug bioavailability to be reliable evaluated. At the same time, the level of magnesium ions was reliable determined in the daily urine of test animals. The relative bioavailability of magnesium for Magnelis B6 versus Magne B6 was estimated at 98.93 +/- 12.45% (average +/- SD).
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: A A
authors.initials: AA
authors.lastname: Litvin
authors.forename: A V
authors.initials: AV
authors.lastname: Solodakhin
authors.forename: V A
authors.initials: VA
authors.lastname: Burmistrov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D007773:Lactates / Q000493:pharmacokinetics* / Q000494:pharmacology; D008274:Magnesium / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D011736:Pyridoxine / Q000493:pharmacokinetics* / Q000494:pharmacology; D011817:Rabbits
chemical_list: D007773:Lactates; D008274:Magnesium; D011736:Pyridoxine