title: Preeclampsia and the risk of large-for-gestational-age infants.
abstract: OBJECTIVE
  We sought to compare the risk of giving birth to large-for-gestational-age (LGA) infants in women with and without preeclampsia, after adjustment for obesity and glucose intolerance.
  
  
  METHODS
  We conducted secondary analysis of a prospective database of pregnant women with and without preeclampsia who delivered infants from 1998 through 2006 at Massachusetts General Hospital (n = 17,465).
  
  
  RESULTS
  The risk of LGA was similar in women with and without preeclampsia (odds ratio, 0.81; 95% confidence interval, 0.59-1.14). After adjustment for body mass index, glucose intolerance, and other factors, the risk of LGA was significantly lower in women with preeclampsia compared to those without preeclampsia (odds ratio, 0.69; 95% confidence interval, 0.49-0.96). Stratified analysis in groups with a higher risk of LGA revealed that preeclampsia has a similar effect on the risk of LGA regardless of maternal obesity, glucose intolerance, parity, and race.
  
  
  CONCLUSIONS
  Preeclampsia appears to be characterized by reduced, and not increased, fetal growth.
authors.affiliation: Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
authors.forename: Camille E
authors.initials: CE
authors.lastname: Powe
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Ecker
authors.forename: Sarosh
authors.initials: S
authors.lastname: Rana
authors.forename: Alice
authors.initials: A
authors.lastname: Wang
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ankers
authors.forename: Jun
authors.initials: J
authors.lastname: Ye
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Levine
authors.forename: S Ananth
authors.initials: SA
authors.lastname: Karumanchi
authors.forename: Ravi
authors.initials: R
authors.lastname: Thadhani
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000502:physiology*; D016208:Databases, Factual; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology* / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D012306:Risk