title: Novel biotinylated bile acid amphiphiles: micellar aggregates formation and interaction with hepatocytes.
abstract: Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases.
authors.affiliation: Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Università degli Studi di Milano, 20133, Milano, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Rizzi
authors.forename: Marta
authors.initials: M
authors.lastname: Braschi
authors.forename: Miriam
authors.initials: M
authors.lastname: Colombo
authors.forename: Nadia
authors.initials: N
authors.lastname: Vaiana
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Tibolla
authors.forename: Giuseppe Danilo
authors.initials: GD
authors.lastname: Norata
authors.forename: Alberico Luigi
authors.initials: AL
authors.lastname: Catapano
authors.forename: Sergio
authors.initials: S
authors.lastname: Romeo
authors.forename: Davide
authors.initials: D
authors.lastname: Prosperi
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000737:chemistry*; D019921:Biotinylation; D045744:Cell Line, Tumor; D022781:Hepatocytes / Q000737:chemistry*; D051379:Mice; D008823:Micelles; D015394:Molecular Structure; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D001647:Bile Acids and Salts; D008823:Micelles; D013501:Surface-Active Agents