title: Transoral laser surgery versus radiotherapy: systematic review and meta-analysis for treatment options of T1a glottic cancer.
abstract: BACKGROUND
  The objective of this study was to conduct a systematic review and meta-analysis to compare the oncologic and functional outcomes between transoral laser surgery (TLS) and radiotherapy (RT).
  
  
  METHODS
  An electronic library search of the relevant English- and Chinese-language literature was conducted. Potentially eligible articles were reviewed. Qualified articles were selected and evaluated.
  
  
  RESULTS
  No significant differences were identified between TLS and RT with respect to local control, overall survival, disease-specific survival, and posttreatment voice quality. However, larynx preservation was significantly higher in patients initially treated with TLS than those initially treated with RT.
  
  
  CONCLUSIONS
  The approach for optimal treatment of T1a glottic cancer remains unanswered. This results from the relatively inconclusive evidence obtained from the current literature. Properly designed, prospective, randomized, or well-controlled studies will be required. Similar methodologies for treatment and reporting need to be established to make a valid and meaningful comparison between studies.
authors.affiliation: Department of Otorhinolaryngology, First Teaching Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Abdurehim
authors.forename: Zhang
authors.initials: Z
authors.lastname: Hua
authors.forename: Yalkun
authors.initials: Y
authors.lastname: Yasin
authors.forename: Ayihen
authors.initials: A
authors.lastname: Xukurhan
authors.forename: Ilham
authors.initials: I
authors.lastname: Imam
authors.forename: Fan
authors.initials: F
authors.lastname: Yuqin
mesh_terms: D005931:Glottis / Q000473:pathology / Q000528:radiation effects / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D009367:Neoplasm Staging; D016019:Survival Analysis; D016896:Treatment Outcome; D014833:Voice Quality