title: Exercise capacity, arrhythmic risk profile, and pulmonary function is not influenced by intracoronary injection of bone marrow stem cells in patients with acute myocardial infarction.
abstract: OBJECTIVE
  To evaluate influence of Bone Marrow Stem Cells (BMSC) intracoronary infusion on exercise capacity, pulmonary function, heart rate recovery and SAECG in patients with AMI of anterior wall, compared to control group--from baseline in the acute phase during 12 months follow up.
  
  
  METHODS
  Forty five patients were randomized 2:1 to BMSC group (n = 31 pts) or to control group (n = 14 pts). BMSC were administered into infarct related artery (IRA) at 4-6 day after primary PCI. Patients were followed up with cardiopulmonary exercise testing. The QRS duration, QT and QTc interval were measured and signal averaged ECGs (SAECG) were performed to evaluate late potentials.
  
  
  RESULTS
  There were no significant differences between both groups neither at peak VO(2) (190.7 ± 7.4 at baseline; 24.2 ± 5.2 at 6 months; 22.2 ± 7.4 ml/kg/min at 12 months vs 18.4 ± 8.2 at baseline; 22.0 ± 7.2 at 6 months; 21.8 ± 6.2 ml/kg/min at 12 months; BMSC vs control group respectively; p = ns), nor VO(2) at anaerobic threshold, nor in VE/VCO(2) slope, RER, and systolic blood pressure at peak exercise at baseline and any time point of follow-up. There were no significant differences between groups concerning HR peak, HRR1 and HRR2 at any time point and also QRS, QT parameters, and SAEKG. There were no significant differences between both groups at any time point (baseline, 6 and 12 months) concerning FVC, FEV(1) and FVC/FEV(1) and % of their normal values.
  
  
  CONCLUSIONS
  We did not find that BMSC therapy in patients with anterior wall myocardial infarction influences exercise capacity. We did not confirm it's potential proarrhythmogenic influence as assessed with SAECG and standard ECG analysis.
authors.affiliation: First Department of Cardiology, Poznań University of Medical Sciences, Poland. ewa.straburzynska-migaj@skpp.edu.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Straburzyńska-Migaj
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Popiel
authors.forename: Stefan
authors.initials: S
authors.lastname: Grajek
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Katarzyńska-Szymańska
authors.forename: Maciej
authors.initials: M
authors.lastname: Lesiak
authors.forename: Piotr
authors.initials: P
authors.lastname: Bręborowicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sawiński
authors.forename: Anna
authors.initials: A
authors.lastname: Czyż
authors.forename: Lidia
authors.initials: L
authors.lastname: Gil
authors.forename: Maria
authors.initials: M
authors.lastname: Kozłowska-Skrzypczak
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Komarnicki
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D003326:Coronary Circulation; D004562:Electrocardiography / Q000379:methods; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D012307:Risk Factors