title: Low-density lipoprotein cholesterol and risk of coronary heart disease among Japanese men and women: the Circulatory Risk in Communities Study (CIRCS).
abstract: OBJECTIVE
  The objective of this study was to assess the association between serum LDL-cholesterol levels and risk of coronary heart disease (CHD) among Japanese who have lower means of LDL-cholesterol than Western populations.
  
  
  METHODS
  The predictive power of estimated serum LDL-cholesterol levels in casual blood samples for risk of CHD was evaluated among residents from four Japanese communities participating in the Circulatory Risk in Communities Study (CIRCS). A total of 8131 men and women, aged 40 to 69 years with no history of stroke or CHD, completed baseline risk factor surveys between 1975 and 1987. By 2003, 155 cases of incident CHD (myocardial infarction, angina pectoris and sudden cardiac death) had been identified.
  
  
  RESULTS
  Mean LDL-cholesterol values were 99.4 mg/dL for men and 109.4 mg/dL for women. The crude incidence rate (per 100,000 person-years) of CHD was 152.0 for men and 51.9 for women. The respective multivariable hazard ratios for ≥ 140 mg/dL versus <80mg/dL LDL-cholesterol were 2.80 (95% confidence interval: 1.59 to 4.92) for total CHD, 3.83 (1.78-8.23) for myocardial infarction, 4.07 (2.02-8.20) for non-fatal CHD, and 1.24 (0.44-3.47) for fatal CHD.
  
  
  CONCLUSIONS
  Serum LDL-cholesterol levels ranging from around 80 mg/dL to 200mg/dL were positively associated with risk of CHD in a Japanese population.
authors.affiliation: Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan. imano@pbhel.med.osaka-u.ac.jp
authors.forename: Hironori
authors.initials: H
authors.lastname: Imano
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Noda
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kitamura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kiyama
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sankai
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohira
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.forename: Ai
authors.initials: A
authors.lastname: Ikeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimamoto
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
mesh_terms: D000328:Adult; D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood*; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology*; D005260:Female; D006306:Health Surveys; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D008078:Cholesterol, LDL