title: Retroviral Transfer of the Herpes Simplex Virus-Thymidine Kinase (HSV-tK) Gene for the Treatment of Cancer.
abstract: Gene therapy is defined as the alteration of the genetic material of a cell with resultant benefit to a patient. Gene transfer has two broad categories: one in which a therapeutic gene is delivered to the cells with the aim of treating a disease; and another where a marker gene is delivered to label a cell type to determine the fate of a cell or the marker gene. Gene therapy is now becoming a rapidly developing therapeutic modality for experimental treatment of some cancers and diseases that have no alternative treatment (1,2).
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, M.D. Anderson Cancer Center, Houston, TX.
authors.forename: R
authors.initials: R
authors.lastname: Ramesh
authors.forename: A
authors.initials: A
authors.lastname: Munshi
authors.forename: A
authors.initials: A
authors.lastname: J Marrogi
authors.forename: S
authors.initials: S
authors.lastname: M Freeman