title: Effects of orchidectomy in selective biochemical analytes in Beagle dogs.
abstract: The objective of this study was to evaluate the possible effects of orchidectomy and associate hormonal changes on circulating concentrations of acute-phase proteins (APPs) (CRP--C-reactive protein; Hp--haptoglobin; Cp--ceruloplasmin), adiponectin and IGF-1 in dogs. For this, a total of five adult Beagle dogs were subjected to orchidectomy. Blood samples were taken before neutering, during six consecutive days and on weeks 2, 4, 8 and 12 after surgery. Appropriate diet regime was maintained to keep stable body weight of the dogs. Concentrations of APPs significantly increased on days 2-3 for CRP and 2-7 for Hp and Cp. On days 3-4 after neutering, adiponectin levels were significantly lower than before surgery (p<0.05 and <0.01, respectively). After this initial change, adiponectin did not show any significant alteration during the 3 months. Serum IGF-1 concentrations were significantly decreased at days 2-5 after neutering. In addition, on weeks 8 and 12 serum IGF-1 levels were significantly lower (p<0.001 and <0.01 respectively) in comparison with those before surgery. In conclusion, orchidectomy induced a short-term inflammatory process that was associated with the increase in serum levels of APPs and decrease in IGF-1 and adiponectin levels. However, orchidectomy did not result in long-term changes of circulating concentrations of APPs or adiponectin. Although a decrease in IGF-1 levels was recorded 2 months after surgery, possibly as a consequence of associated decrease in androgen levels or food restriction.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, Murcia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.forename: S
authors.initials: S
authors.lastname: Martinez-Subiela
authors.forename: J D
authors.initials: JD
authors.lastname: Carrillo-Sanchez
authors.forename: F
authors.initials: F
authors.lastname: Tecles
authors.forename: J J
authors.initials: JJ
authors.lastname: Ceron
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism*; D004285:Dogs; D006242:Haptoglobins / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy / Q000662:veterinary*
chemical_list: D052242:Adiponectin; D006242:Haptoglobins; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein; D002570:Ceruloplasmin