title: [A case of unresectable rectal cancer with severe pelvic infiltration responding to FOLFOX].
abstract: The patient was a 54-year-old male with a huge advanced rectal cancer tumor. Abdominal CT showed liver metastasis and local progressive cancer of the rectum measuring 13 × 9 × 7 cm in diameter, which invaded the urinary bladder and sacrum. We established a diagnosis of unresectable rectal cancer and then performed sigmoid colostomy. After 16 courses of FOLFOX4, abdominal CT revealed the liver metastases to have disappeared, and the large-sized advanced rectal cancer had also remarkably decreased in size. Consequently, the patient underwent a resection of the rectum while his bladder was preserved. For 2 years 10 months after surgery, no local recurrence or distant metastasis has been observed, and the patient has received no postoperative chemotherapy. FOLFOX may therefore be a useful preoperative chemotherapy for the patients with unresectable primary rectal cancer.
authors.affiliation: Dept. of Surgery, Hidaka General Hospital, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Yamazoe
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Terasawa
authors.forename: Toshiyasu
authors.initials: T
authors.lastname: Ojima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tsujimura
authors.forename: Tomoo
authors.initials: T
authors.lastname: Shimomura
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D010388:Pelvis / Q000473:pathology*; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil