title: Discovery of novel methanone derivatives acting as antimycobacterial agents.
abstract: A series of pyrazoline derivatives were synthesized and in vitro activity against Mycobacterium tuberculosis H37Rv was carried out. Among the synthesized compounds, compounds (4d) and (4f) 4-aminophenyl-3-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-ylmethanone and 4-aminophenyl-6,7-dimethoxy-3-phenyl-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-ylmethanone were found to be the most active agent against M. tuberculosis H37Rv with a minimum inhibitory concentration of 10 μg/mL.
authors.affiliation: Pharmacogenetic and Novel Therapeutics Research, Institute for Research in Molecular Medicine, Universiti of Sains Malaysia, Pennag, Malaysia. asraf80med@rediffmail.com
authors.forename: Mohamed Ashraf
authors.initials: MA
authors.lastname: Ali
authors.forename: Sylvaine
authors.initials: S
authors.lastname: Bastian
authors.forename: Rusli
authors.initials: R
authors.lastname: Ismail
authors.forename: Tan Soo
authors.initials: TS
authors.lastname: Choon
authors.forename: Sadath
authors.initials: S
authors.lastname: Ali
authors.forename: Alexandra
authors.initials: A
authors.lastname: Aubry
authors.forename: Suresh
authors.initials: S
authors.lastname: Pandian
authors.forename: Pankaj
authors.initials: P
authors.lastname: Saraswat
authors.forename: Abhimanyu
authors.initials: A
authors.lastname: Singh
authors.forename: Ramakant
authors.initials: R
authors.lastname: Gaur
mesh_terms: D055808:Drug Discovery; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D011720:Pyrazoles