title: [Four cases of interstitial pneumonia associated with amyopathic dermatomyositis characterized by the anti-CADM-140 antibody].
abstract: Clinically amyopathic dermatomyositis (CADM) is a subgroup of dermatomyositis that manifests with characteristic cutaneous lesions and mild or no muscle involvement. It is known that rapidly progressive interstitial pneumonia with a poor prognosis can occur in patients with CADM. The anti-CADM-140 antibody is thought to be useful as a specific serological marker for CADM. We encountered 4 patients with the anti-CADM-140 antibody. All patients complained of cutaneous lesions and dyspnea. Chest X-ray films and CT scans showed ground-glass opacities (GGO) and consolidation in the lower lobes. All cases were treated with pulse methylprednisolone, cyclophosphamide therapy and cyclosporine. Three patients died of respiratory failure and 1 improved. Anti-CADM-140 antibody-positive cases are likely to have poor prognoses and should be treated by intensive therapy as soon as possible.
authors.affiliation: Department of Pulmonary Medicine, Kobe City Medical Center General Hospital.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Nagata
authors.forename: Keisuke
authors.initials: K
authors.lastname: Tomii
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nanjo
authors.forename: Mio
authors.initials: M
authors.lastname: Kubota
authors.forename: Ryo
authors.initials: R
authors.lastname: Tachikawa
authors.forename: Mari
authors.initials: M
authors.lastname: Nishio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D003882:Dermatomyositis / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D017563:Lung Diseases, Interstitial / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000276:immunology*
chemical_list: D001323:Autoantibodies; C501597:CADM-140 peptide, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides