title: [A case of synchronous hepatic and multiple pulmonary metastases from rectal cancer responding completely to UFT therapy after resection of primary and hepatic lesions].
abstract: We report a case of disease-free survival with uracil-tegafur(UFT)therapy after resection of primary and hepatic lesions from rectal cancer. A 64-year-old female had synchronous hepatic and multiple pulmonary metastases from rectal cancer. Image studies including colonoscopy, CT, MRI and PET-CT showed 2 metastases of lung(rt. middle lobe and lt. upper lobe) and a metastasis of liver(S6)in addition to rectal cancer(Rb, pSM, pN1, ly2, v1). Abdominoperineal resection+D3 of rectal cancer was performed, followed by chemotherapy with UFT for 28 days, and then partial resection of liver. Resected specimens of the liver demonstrated a histological Grade 2 with many CD3-positive lymphocytes. After surgeries, chemotherapy with UFT was continued, resulting in a CR for pulmonary metastases. The patient has been well without any sign of recurrence 5 years after first surgery. This case indicated that UFT was effective for hepatic and pulmonary metastases from rectal cancer, partially due to T cells(CD3+)infiltrating the metastases.
authors.affiliation: Dept. of Surgery, Osaka Kaisei Hospital.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kusumoto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Toyoda
authors.forename: Teppei
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Nami
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Chie
authors.initials: C
authors.lastname: Kusumoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Kohro
authors.forename: Fukashi
authors.initials: F
authors.lastname: Doi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012074:Remission Induction; D005641:Tegafur / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014498:Uracil / Q000627:therapeutic use
chemical_list: D005641:Tegafur; D014498:Uracil