title: Antifungal and cytotoxic activities of the secondary metabolites from endophytic fungus Massrison sp.
abstract: Three novel compounds with spiro-5, 6-lactone ring skeleton has been isolated from the fermentation broth of Massrison sp. which could be isolated repeatedly from wild Rehmannia glutinosa. Psetariae oryza P-2b was applied to guide fractionation of bioactive compounds produced by Massrison sp. The molecular structures were established by a variety of one- and two-dimensional NMR experiments and the compounds with similar skeleton were reported for the first time from endophytic fungi of terraneous plant. Antifungal and cytotoxic activities of the compounds were tested, compounds 2 and 3 displayed stronger antifungal and cytotoxic activities. The compounds have the potential to be antibiotic against fungal pathogens and tumor cells.
authors.affiliation: Branch Hospital in Fengxian of Shanghai No. 6 People's Hospital, No. 9588, Nanfeng Road, Fengxian District, Shanghai, PR China.
authors.forename: Zhen-Liang
authors.initials: ZL
authors.lastname: Sun
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Ji-Fa
authors.initials: JF
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003512:Cyclohexanones / Q000737:chemistry / Q000494:pharmacology*; D005285:Fermentation; D005658:Fungi / Q000737:chemistry* / Q000254:growth & development; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D018517:Plant Roots / Q000382:microbiology; D032267:Rehmannia / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D003512:Cyclohexanones; C521872:spiromassaritone