title: Successful management of invasive aspergillosis with voriconazole and amphoteracin B therapy in a patient with acute mycloid leukemia (AML-M2).
abstract: An eleven-year-old boy presented with one month's history of fever and weight loss. He was diagnosed with Acute Mycloid Leukemia (AML-M2). During treatment he developed recurrent infections with neutropenia requiring prolonged antibiotics and subsequently developed invasive aspergillosis. He was treated with amphotericin B and Voriconazole. This case shows the efficacy and safety of combined antifungal therapy, including voriconazole, for invasive aspergillosis complicating AML.
authors.affiliation: Aga Khan University Hospital, Karachi.
authors.forename: Nauman Fazal
authors.initials: NF
authors.lastname: Manzoor
authors.forename: Sidra
authors.initials: S
authors.lastname: Azim
authors.forename: Zehra
authors.initials: Z
authors.lastname: Fadoo
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D005334:Fever / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole