title: Sonocatalyzed synthesis of 2-phenylvaleronitrile under controlled reaction conditions--a kinetic study.
abstract: In the current study, kinetics of synthesis of 2-phenylvaleronitrile (PVN) was successfully carried out by selective C-alkylation of benzyl cyanide (BC) with n-bromopropane (BP) using aqueous KOH and catalyzed by TBAB under ultrasonic (300W) assisted organic solvent-free conditions. Selective monoalkylation of benzyl cyanide has been achieved by controlling the reaction conditions and has been followed using gas chromatogram. The effects of various parameters such as agitation speed, catalyst concentration, KOH concentration, benzyl cyanide concentration, volume of water, ultrasonic frequency and temperature were studied systematically to understand their influence on the rate of the reaction. The experimental observations are consistent with an interfacial-type process. Further the kinetic results demonstrate clearly, that ultrasonic assisted phase-transfer catalysis significantly increased the reaction rate when compared to silent reactions.
authors.affiliation: Department of Environmental Engineering, Safety and Health, Hungkuang University, Shalu, Taichung County, Taiwan, Taiwan, ROC.
authors.forename: P A
authors.initials: PA
authors.lastname: Vivekanand
authors.forename: Maw-Ling
authors.initials: ML
authors.lastname: Wang
mesh_terms: D000097:Acetonitriles / Q000737:chemistry* / Q000528:radiation effects*; D003198:Computer Simulation; D007700:Kinetics; D008956:Models, Chemical; D009570:Nitriles / Q000138:chemical synthesis* / Q000528:radiation effects*; D011829:Radiation Dosage; D013010:Sonication / Q000379:methods*
chemical_list: D000097:Acetonitriles; D009570:Nitriles; C006725:benzyl cyanide