title: [Osteoporosis--pathophysiology and laboratory diagnostic methods].
abstract: Osteoporosis is the most common systemic skeletal disease characterized by low bone mass, increased bone turnover, and subsequent increased susceptibility to fracture. The aim of this paper was to present a molecular basis of bone remodeling, pathogenesis and different types of osteoporosis. Diagnostic studies, including bone densitometry and laboratory analysis were also reviewed.
authors.affiliation: Katedra i Zakład Chemii Klinicznej i Diagnostyki Laboratoryjnej, Slaski Uniwersytet Medyczny, Sosnowiec. kvassev@sum.edu.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Komosińska-Vassev
authors.forename: Paweł
authors.initials: P
authors.lastname: Olczyk
authors.forename: Krystyna
authors.initials: K
authors.lastname: Olczyk
authors.forename: Dorota
authors.initials: D
authors.lastname: Blat
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000503:physiopathology; D002118:Calcium / Q000097:blood / Q000627:therapeutic use; D024042:Collagen Type I / Q000378:metabolism; D005260:Female; D050723:Fractures, Bone / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D010024:Osteoporosis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology* / Q000517:prevention & control; D053244:Osteoprotegerin / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism; D012307:Risk Factors; D014807:Vitamin D / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D014807:Vitamin D; D000469:Alkaline Phosphatase; D006909:Hydroxyproline; D002118:Calcium