title: Subthalamic deep brain stimulation for the treatment of Parkinson disease.
abstract: OBJECTIVE
  The role of subthalamic nucleus deep brain stimulation (STN DBS) in the treatment of Parkinson disease (PD) is well established. The authors present a group of patients diagnosed with PD who were treated with STN DBS.
  
  
  METHODS
  Between 2008 and 2009, 32 female and 34 male patients with PD were treated with STN DBS. Mean age at implantation was 57 ± 12 years. PD lasted from 6 to 21 years (mean 10 years). Patients were qualified for the surgery according to the CAPSIT-PD criteria. The STN was identified with direct and indirect methods. Macrostimulation and microrecording for STN identification were used in all cases. A unilateral STN DBS system was implanted in two cases and bilateral implantation was performed among rest of the group. Outcome was assessed six months after implantation. Results : The mean reduction of UPDRS III score among 51 patients who underwent follow-up was 45% (5-89%). Reduction of levodopa consumption varied from 15 to 100%. Infection forced the authors to remove the DBS system in one case four months after implantation. Skin erosion above the internal pulse generator was noted in four cases.
  
  
  CONCLUSIONS
  Cardinal symptoms of Parkinson's disease can be safely and effectively treated with STN DBS in selected group of patients.
authors.affiliation: Centrum Onkologii - Instytut, Klinika Nowotworów Układu Nerwowego, ul. Roentgena 5, 02-781 Warszawa. tomaszmandat@yahoo.com
authors.forename: Tomasz
authors.initials: T
authors.lastname: Mandat
authors.forename: Tomasz
authors.initials: T
authors.lastname: Tykocki
authors.forename: Henryk
authors.initials: H
authors.lastname: Koziara
authors.forename: Dariusz
authors.initials: D
authors.lastname: Koziorowski
authors.forename: Bogdan
authors.initials: B
authors.lastname: Brodacki
authors.forename: Rafał
authors.initials: R
authors.lastname: Rola
authors.forename: Wiesław
authors.initials: W
authors.lastname: Bonicki
authors.forename: Paweł
authors.initials: P
authors.lastname: Nauman
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation / Q000009:adverse effects* / Q000379:methods*; D004567:Electrodes, Implanted / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D019919:Prosthesis Implantation / Q000009:adverse effects*; D016459:Prosthesis-Related Infections / Q000209:etiology; D012883:Skin Ulcer / Q000209:etiology; D020531:Subthalamic Nucleus / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome