title: Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China.
abstract: Human adenovirus (HAdV) is a causative agent of acute respiratory disease, which is prevalent throughout the world. Recently there are some reports which found that the HAdV-3 and HAdV-5 genomes were very stable across 50 years of time and space. But more and more recombinant genomes have been identified in emergent HAdV pathogens and it is a pathway for the molecular evolution of types. In our paper, we found a HAdV-7 GZ07 strain isolated from a child with acute respiratory disease, whose genome was E3-partial deleted. The whole genome was 32442 bp with 2864 bp deleted in E3 region and was annotated in detail (GenBank: HQ659699). The growth character was the same as that of another HAdV-7 wild strain which had no gene deletion. By comparison with E3 regions of the other HAdV-B, we found that only left-end two proteins were remained: 12.1 kDa glycoprotein and 16.1 kDa protein. E3 MHC class I antigen-binding glycoprotein, hypothetical 20.6 kDa protein, 20.6 kDa protein, 7.7 kDa protein., 10.3 kDa protein, 14.9 kDa protein and E3 14.7 kDa protein were all missing. It is the first report about E3 deletion in human adenovirus, which suggests that E3 region is also a possible recombination region in adenovirus molecular evolution.
authors.affiliation: Key Laboratory of Tropical Marine Environmental Dynamics, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, PR China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Su
authors.forename: Xingui
authors.initials: X
authors.lastname: Tian
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Zhang
authors.forename: Haitao
authors.initials: H
authors.lastname: Li
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.forename: Huiying
authors.initials: H
authors.lastname: Sheng
authors.forename: Youshao
authors.initials: Y
authors.lastname: Wang
authors.forename: Houbo
authors.initials: H
authors.lastname: Wu
authors.forename: Rong
authors.initials: R
authors.lastname: Zhou
mesh_terms: D017503:Adenovirus E3 Proteins / Q000235:genetics*; D000258:Adenovirus Infections, Human / Q000821:virology*; D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D002460:Cell Line; D002648:Child; D002681:China; D017353:Gene Deletion; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny
chemical_list: D017503:Adenovirus E3 Proteins