title: Induced pluripotent stem cells for regenerative cardiovascular therapies and biomedical discovery.
abstract: The discovery of induced pluripotent stem cells (iPSC) has, in the short time since their discovery, revolutionized the field of stem cell biology. This technology allows the generation of a virtually unlimited supply of cells with pluripotent potential similar to that of embryonic stem cells (ESC). However, in contrast to ESC, iPSC are not subject to the same ethical concerns and can be easily generated from living individuals. For the first time, patient-specific iPSC can be generated and offer a supply of genetically identical cells that can be differentiated into all somatic cell types for potential use in regenerative therapies or drug screening and testing. As the techniques for generation of iPSC lines are constantly evolving, new uses for human iPSC are emerging from in-vitro disease modeling to high throughput drug discovery and screening. This technology promises to revolutionize the field of medicine and offers new hope for understanding and treatment of numerous diseases.
authors.affiliation: Department of Medicine, Cardiovascular Research Laboratories and Eli Broad Center for Regenerative Medicine and Stem Cell Research,David Geffen School of Medicine at UCLA, United States
authors.forename: Ali
authors.initials: A
authors.lastname: Nsair
authors.forename: W Robb
authors.initials: WR
authors.lastname: MacLellan
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000628:therapy*; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D055808:Drug Discovery / Q000379:methods; D057166:High-Throughput Screening Assays; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism*; D044968:Regenerative Medicine / Q000379:methods*