title: Development and validation of a quality of life instrument for patients with drug dependence: comparisons with SF-36 and WHOQOL-100.
abstract: OBJECTIVE
  Our goal was to develop a self-administered quality of life scale for patients with drug addiction/dependence (QOL-DA) and compare it with the SF-36 and the WHOQOL-100.
  
  
  METHODS
  Employing theory and methodology of rating scale construction, a self-administered quality of life instrument for individuals with drug dependence QOL-DA was developed and evaluated utilizing responses from 212 drug-dependent subjects at the Kunming Municipal Mandatory Detoxification and Rehabilitation Center in China. Quality of life was measured using the SF-36, WHOQOL-100 and QOL-DA three times during the detoxification.
  
  
  RESULTS
  Test-retest reliability in the domains of physical function, psychological function, social function and toxicity were 0.82, 0.64, 0.78, and 0.76, respectively. Cronbach's coefficient α for the 4 domains was 0.87, 0.89, 0.93 and 0.86, respectively. Correlations and factor analysis showed good construct validity. Criterion-related and convergent validity was confirmed by using the SF-36 and the WHOQOL-100 simultaneously. The instrument does show the change in QOL after two weeks of detoxification with higher standardized response mean higher than that of SF-36 and WHOQOL-100.
  
  
  CONCLUSIONS
  The instrument developed has good validity, reliability and better responsiveness than instruments currently used, and can be employed effectively to measure the quality of life of individuals with drug dependence.
authors.affiliation: School of Humanities and Management, Guangdong Medical College, Dongguan, China. wanchh@hotmail.com
authors.forename: Chonghua
authors.initials: C
authors.lastname: Wan
authors.forename: Jiqian
authors.initials: J
authors.lastname: Fang
authors.forename: Runsheng
authors.initials: R
authors.lastname: Jiang
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.forename: Dan
authors.initials: D
authors.lastname: Jiang
authors.forename: Xin
authors.initials: X
authors.lastname: Tu
authors.forename: Susan
authors.initials: S
authors.lastname: Messing
authors.forename: Wan
authors.initials: W
authors.lastname: Tang
mesh_terms: D002681:China; D006801:Humans; D011788:Quality of Life; D019966:Substance-Related Disorders / Q000503:physiopathology*