title: Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats.
abstract: This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus.
authors.affiliation: Uludag University Science and Arts Faculty, Department of Biology, Bursa, Turkey. smeral@uludag.edu.tr
authors.forename: Sibel
authors.initials: S
authors.lastname: Tas
authors.forename: Serap
authors.initials: S
authors.lastname: Celikler
authors.forename: Sedef
authors.initials: S
authors.lastname: Ziyanok-Ayvalik
authors.forename: Emre
authors.initials: E
authors.lastname: Sarandol
authors.forename: Melahat
authors.initials: M
authors.lastname: Dirican
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D028321:Plant Preparations / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D044445:Ulva / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D028321:Plant Preparations; D008315:Malondialdehyde