title: Asymmetric total synthesis of clavolonine.
abstract: The asymmetric total synthesis of clavolonine (1) has been achieved based on chiral auxiliary multiple-use methodology. Our synthetic route features stereoselective transformations on the cyclohexane ring utilizing the steric environment of the chiral auxiliary and an intramolecular Mannich reaction to construct the fused ring system.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871 Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakahara
authors.forename: Kie
authors.initials: K
authors.lastname: Hirano
authors.forename: Ryota
authors.initials: R
authors.lastname: Maehata
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kita
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Fujioka
mesh_terms: D015394:Molecular Structure; D011807:Quinolizines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D011807:Quinolizines; C513871:clavolonine