title: The Occluded Artery Trial (OAT) Viability Ancillary Study (OAT-NUC): influence of infarct zone viability on left ventricular remodeling after percutaneous coronary intervention versus optimal medical therapy alone.
abstract: BACKGROUND
  The Occluded Artery Trial (OAT) showed no difference in outcomes between percutaneous coronary intervention (PCI) versus optimal medical therapy (MED) in patients with persistent total occlusion of the infarct-related artery 3 to 28 days post-myocardial infarction. Whether PCI may benefit a subset of patients with preservation of infarct zone (IZ) viability is unknown.
  
  
  RESULTS
  The OAT nuclear ancillary study hypothesized that (1) IZ viability influences left ventricular (LV) remodeling and that (2) PCI as compared with MED attenuates adverse remodeling in post-myocardial infarction patients with preserved viability. Enrolled were 124 OAT patients who underwent resting nitroglycerin-enhanced technetium-99m sestamibi single-photon emission computed tomography (SPECT) before OAT randomization, with repeat imaging at 1 year. All images were quantitatively analyzed for infarct size, IZ viability, LV volumes, and function in a core laboratory. At baseline, mean infarct size was 26% ± 18 of the LV, mean IZ viability was 43% ± 8 of peak uptake, and most patients (70%) had at least moderately retained IZ viability. There were no significant differences in 1-year end-diastolic or end-systolic volume change between those with severely reduced versus moderately retained IZ viability, or when compared by treatment assignment PCI versus MED. In multivariable models, increasing baseline viability independently predicted improvement in ejection fraction (P = .005). There was no interaction between IZ viability and treatment assignment for any measure of LV remodeling.
  
  
  CONCLUSIONS
  In the contemporary era of MED, PCI of the infarct-related artery compared with MED alone does not impact LV remodeling irrespective of IZ viability.
authors.affiliation: Tufts Medical Center, Boston, MA 02111, USA. judelson@tuftsmedicalcenter.org
authors.forename: James E
authors.initials: JE
authors.lastname: Udelson
authors.forename: Camille A
authors.initials: CA
authors.lastname: Pearte
authors.forename: Carey D
authors.initials: CD
authors.lastname: Kimmelstiel
authors.forename: Mariusz
authors.initials: M
authors.lastname: Kruk
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kufera
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Forman
authors.forename: Anna
authors.initials: A
authors.lastname: Teresinska
authors.forename: Bartosz
authors.initials: B
authors.lastname: Bychowiec
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Marin-Neto
authors.forename: Thomas
authors.initials: T
authors.lastname: Höchtl
authors.forename: Eric A
authors.initials: EA
authors.lastname: Cohen
authors.forename: Paulo
authors.initials: P
authors.lastname: Caramori
authors.forename: Benita
authors.initials: B
authors.lastname: Busz-Papiez
authors.forename: Christopher
authors.initials: C
authors.lastname: Adlbrecht
authors.forename: Zygmunt P
authors.initials: ZP
authors.lastname: Sadowski
authors.forename: Witold
authors.initials: W
authors.lastname: Ruzyllo
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Kinan
authors.forename: Gervasio A
authors.initials: GA
authors.lastname: Lamas
authors.forename: Judith S
authors.initials: JS
authors.lastname: Hochman
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D054059:Coronary Occlusion / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy; D013318:Stroke Volume; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000473:pathology / Q000503:physiopathology; D020257:Ventricular Remodeling