title: Evaluation of perinatal and intrafamilial hepatitis B prevention programmes in a well child clinic: 9-year follow-up study in Turkey.
abstract: Evaluating the performance of well child clinics on adherence to recommended perinatal hepatitis B prevention programmes as well as assessing the outcome of infants living with hepatitis B surface antigen (HBsAg)-positive parents is important. A retrospective study was performed of 336 babies who had at least one HBsAg-positive parent and were followed-up in the well child clinic of Gazi University Hospital (Ankara, Turkey) between 2001 and 2009. Rates of passive immunisation in 109 babies with HBsAg-positive mothers and initiation of hepatitis B vaccination of all 336 babies with HBsAg-positive parents were 98.8% and 100% respectively. Ninety-two babies (27.4%) were lost to follow-up before completing primary immunisation. The recommended perinatal hepatitis B prevention programme was performed successfully in 194 of the 306 infants who were old enough for post-vaccination serotesting (63.4%). One baby became HBsAg-positive, and 88.1% of babies were seroprotected. Hepatitis B surface antibody (anti-HBs) levels were found to be increased if the HBsAg-positive parent was the father. There was a negative correlation between serotesting time and anti-HBs titres. The study infants had a total of 187 siblings and 123 (65.8%) were serotested after completing primary immunisation with 108 found to be seropositive. Although the vaccination rate in the perinatal hepatitis B prevention programme is satisfactory, post-vaccination serotesting and evaluation of infants and their siblings are still deficient.
authors.affiliation: Mersin University School of Medicine, Department of Social Pediatrics, Zeytinlibahce, Mersin, 33079, Turkey. seldapolat2003@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Polat
authors.forename: A D
authors.initials: AD
authors.lastname: Camurdan
authors.forename: N
authors.initials: N
authors.lastname: Aksakal
authors.forename: S
authors.initials: S
authors.lastname: Agladioglu
authors.forename: U
authors.initials: U
authors.lastname: Beyazova
authors.forename: F
authors.initials: F
authors.lastname: Sahin
authors.forename: A
authors.initials: A
authors.lastname: Atak
authors.forename: A
authors.initials: A
authors.lastname: Er
mesh_terms: D002353:Carrier State; D005260:Female; D005500:Follow-Up Studies; D019983:Guideline Adherence / Q000592:standards; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D017325:Hepatitis B Vaccines; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D010290:Parents; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines