title: Neuromyelitis optica unique area postrema lesions: nausea, vomiting, and pathogenic implications.
abstract: OBJECTIVE
  To characterize the neuropathologic features of neuromyelitis optica (NMO) at the medullary floor of the fourth ventricle and area postrema. Aquaporin-4 (AQP4) autoimmunity targets this region, resulting in intractable nausea associated with vomiting or hiccups in NMO.
  
  
  METHODS
  This neuropathologic study was performed on archival brainstem tissue from 15 patients with NMO, 5 patients with multiple sclerosis (MS), and 8 neurologically normal subjects. Logistic regression was used to evaluate whether the presence of lesions at this level increased the odds of a patient with NMO having an episode of nausea/vomiting.
  
  
  RESULTS
  Six patients with NMO (40%), but no patients with MS or normal controls, exhibited unilateral or bilateral lesions involving the area postrema and the medullary floor of the fourth ventricle. These lesions were characterized by tissue rarefaction, blood vessel thickening, no obvious neuronal or axonal pathology, and preservation of myelin in the subependymal medullary tegmentum. AQP4 immunoreactivity was lost or markedly reduced in all 6 cases, with moderate to marked perivascular and parenchymal lymphocytic inflammatory infiltrates, prominent microglial activation, and in 3 cases, eosinophils. Complement deposition in astrocytes, macrophages, and/or perivascularly, and a prominent astroglial reaction were also present. The odds of nausea/vomiting being documented clinically was 16-fold greater in NMO cases with area postrema lesions (95% confidence interval 1.43-437, p = 0.02).
  
  
  CONCLUSIONS
  These neuropathologic findings suggest the area postrema may be a selective target of the disease process in NMO, and are compatible with clinical reports of nausea and vomiting preceding episodes of optic neuritis and transverse myelitis or being the heralding symptom of NMO.
authors.affiliation: Mayo Clinic, College of Medicine, Rochester, MN 55905, USA.
authors.forename: B F Gh
authors.initials: BF
authors.lastname: Popescu
authors.forename: V A
authors.initials: VA
authors.lastname: Lennon
authors.forename: J E
authors.initials: JE
authors.lastname: Parisi
authors.forename: C L
authors.initials: CL
authors.lastname: Howe
authors.forename: S D
authors.initials: SD
authors.lastname: Weigand
authors.forename: J A
authors.initials: JA
authors.lastname: Cabrera-Gómez
authors.forename: K
authors.initials: K
authors.lastname: Newell
authors.forename: R N
authors.initials: RN
authors.lastname: Mandler
authors.forename: S J
authors.initials: SJ
authors.lastname: Pittock
authors.forename: B G
authors.initials: BG
authors.lastname: Weinshenker
authors.forename: C F
authors.initials: CF
authors.lastname: Lucchinetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D031608:Area Postrema / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009325:Nausea / Q000150:complications / Q000209:etiology / Q000473:pathology*; D009471:Neuromyelitis Optica / Q000150:complications / Q000209:etiology* / Q000473:pathology*; D012189:Retrospective Studies; D014839:Vomiting / Q000150:complications / Q000209:etiology / Q000473:pathology*; D055815:Young Adult