title: Diets high in corn oil or extra-virgin olive oil provided from weaning advance sexual maturation and differentially modify susceptibility to mammary carcinogenesis in female rats.
abstract: Based on the importance of early-life events in breast cancer risk, we have investigated the effects of high-fat diets on maturation, mammary gland development, and its susceptibility to transformation. Female Sprague-Dawley rats were fed a lowfat (LF), high corn oil (HCO), or high extra-virgin olive oil (HOO) diet from weaning and gavaged with 7,12-dimethylbenz[a]anthracene. Body weight and mass increased in the HCO group compared to the LF group. The vaginal opening was advanced in both high-fat groups, especially in the HCO group. This HCO group also had increased body weight around puberty, more corpora lutea at post-puberty, and tended to have higher kisspeptin levels in the hypothalamus. Both high-fat diets induced subtle modifications in the morphology of the mammary gland, with no changes on β-casein or hormone receptors expression in the gland. The HCO diet had a clearly stimulating effect of carcinogenesis, inducing the earliest appearance of tumors and the highest tumor incidence and yield, whereas the HOO diet seemed to have a weak enhancing effect, increasing tumor yield. Our data suggest a strong influence of the HCO diet in sexual maturation and mammary cancer risk, while rats fed the HOO diet were more similar to the controls.
authors.affiliation: Department of Cell Biology, Physiology and Immunology, Physiology Unit, Medicine School, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Moral
authors.forename: Raquel
authors.initials: R
authors.lastname: Escrich
authors.forename: Montserrat
authors.initials: M
authors.lastname: Solanas
authors.forename: Elena
authors.initials: E
authors.lastname: Vela
authors.forename: Irmgard
authors.initials: I
authors.lastname: Costa
authors.forename: M Carme Ruiz
authors.initials: MC
authors.lastname: de Villa
authors.forename: Eduard
authors.initials: E
authors.lastname: Escrich
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000595:Amino Acid Sequence; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D001940:Breast / Q000254:growth & development / Q000473:pathology*; D002364:Caseins / Q000032:analysis / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003314:Corn Oil / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D047628:Estrogen Receptor alpha / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D059648:Kisspeptins; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D008969:Molecular Sequence Data; D000069463:Olive Oil; D010053:Ovary / Q000254:growth & development / Q000473:pathology; D010938:Plant Oils / Q000008:administration & dosage*; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012741:Sexual Maturation
chemical_list: D002364:Caseins; D004041:Dietary Fats; D047628:Estrogen Receptor alpha; C491406:Kiss1 protein, rat; D059648:Kisspeptins; D000069463:Olive Oil; D010938:Plant Oils; D011506:Proteins; D012333:RNA, Messenger; D015127:9,10-Dimethyl-1,2-benzanthracene; D003314:Corn Oil