title: Significant association of caveolin-1 (CAV1) genotypes with prostate cancer susceptibility in Taiwan.
abstract: BACKGROUND
  Multiple lines of evidence have implicated the Caveolin-1 (CAV1) gene in prostate cancer progression. CAV1 is located within the locus at 7q31-33 associated with prostate cancer aggressiveness, and was identified as being overexpressed in prostate tumors. Therefore, this study evaluated the relationship between the polymorphism of CAV1 and the risk of prostate cancer in Taiwan.
  
  
  METHODS
  Two hundred and fifty patients with prostate cancer and five hundred age-matched healthy controls recruited were genotyped.
  
  
  RESULTS
  There were significant differences between prostate cancer and control groups in the distributions of their genotypes (p = 0.0004) and allelic frequencies (p = 4.9 × 10(-5)) in the CAV1 T29107A (rs7804372) polymorphisms.
  
  
  CONCLUSIONS
  This study provides evidence for the relationship of this variant of CAV1 and risk of prostate cancer which might merit further study as a genomic marker for early detection of prostate cancer.
authors.affiliation: Department of Urology, China Medical University Hospital, Taichung, Taiwan, ROC.
authors.forename: Hsi-Chin
authors.initials: HC
authors.lastname: Wu
authors.forename: Chao-Hsiang
authors.initials: CH
authors.lastname: Chang
authors.forename: Yung-An
authors.initials: YA
authors.lastname: Tsou
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
mesh_terms: D016022:Case-Control Studies; D051242:Caveolin 1 / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*
chemical_list: D051242:Caveolin 1