title: Two cases of cancer-associated retinopathy combined with small-cell lung cancer.
abstract: Cancer-associated retinopathy is a rare paraneoplastic syndrome that is often associated with small-cell lung cancer. It is caused by an autoantibody to the 23 kDa photoreceptor protein, recoverin. A small number of reports have described effective treatment for the disease. We report two cases of cancer-associated retinopathy with small-cell lung cancer whose visual symptom preceded the diagnosis of cancer. Their visual acuity and visual field were slightly improved after steroid and anticancer therapy. Steroid therapy was effective, although the period from visual symptom onset to therapy was comparative longer. When cancer-associated retinopathy is suspected, a comparatively large quantity of steroids and anticancer treatment should be combined immediately.
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sakamori
authors.forename: Young Hak
authors.initials: YH
authors.lastname: Kim
authors.forename: Chiyuki
authors.initials: C
authors.lastname: Okuda
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Togashi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kinose
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Masago
authors.forename: Tadashi
authors.initials: T
authors.lastname: Mio
authors.forename: Akihito
authors.initials: A
authors.lastname: Uji
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D010257:Paraneoplastic Syndromes / Q000175:diagnosis*; D051603:Recoverin / Q000032:analysis; D012164:Retinal Diseases / Q000150:complications / Q000209:etiology*; D014786:Vision Disorders / Q000209:etiology*; D014792:Visual Acuity; D014794:Visual Fields
chemical_list: D014408:Biomarkers, Tumor; D051603:Recoverin