title: Clinical features of late-onset poststroke seizures.
abstract: BACKGROUND
  Compared to the patients with early-onset seizures (ES), those with late-onset seizures (LS) have a high risk of epilepsy that is a feared complication after stroke. However, few studies have described detailed clinical features of LS in Japanese patients.
  
  
  METHODS
  To elucidate the clinical features of LS, a series of 448 stroke patients (cerebral infarction n = 286; cerebral hemorrhage n = 162) in our hospital were retrospectively examined in this study. Stroke location was determined by computed tomographic and/or magnetic resonance imaging scans. Lesion size was evaluated using the Alberta Stroke Program Early Computed Tomographic Score. We examined occurrence rate, onset time, and recurrence rate of LS. In addition, clinical features of the infarction of LS and non-LS group were compared on age, gender, laterality, location, and extent, respectively.
  
  
  RESULTS
  LS occurred in 18 patients (4.0%). Of these, 17 experienced LS within 1.5 years after stroke. While epilepsy developed in none of the patients with ES, it developed in 33% of those with LS. Patients with cortical and a larger infarction involving the middle cerebral artery had at significantly greater risk of LS (P < .05).
  
  
  CONCLUSIONS
  Patients with cortical and a larger infarction involving the middle cerebral artery should be carefully observed because of a high risk of LS.
authors.affiliation: Department of Neurology at Hyogo Rehabilitation Center Hospital, Kobe, Japan. s_okuda@hwc.or.jp
authors.forename: Shiho
authors.initials: S
authors.lastname: Okuda
authors.forename: Shin
authors.initials: S
authors.lastname: Takano
authors.forename: Masao
authors.initials: M
authors.lastname: Ueno
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Hamaguchi
authors.forename: Fumio
authors.initials: F
authors.lastname: Kanda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D002544:Cerebral Infarction / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012640:Seizures / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D055815:Young Adult