title: Thrombophilia and pre-eclampsia.
abstract: Pre-eclampsia (P-EC) poses an increased risk for fetal and maternal morbidity and sometimes even mortality. Several risk factors have been identified, among which an important extensively studied group is formed by the early recognizable genetic factors resulting in thrombophilia. The discussion is ongoing whether the associations found for thrombophilia are true and clinically relevant. In this review, we address the association between P-EC and thrombophilia, its concerns, and the necessity of screening after a pregnancy complicated by hypertension.
authors.affiliation: Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands. m.demaat@erasmusmc.nl
authors.forename: Moniek P M
authors.initials: MP
authors.lastname: de Maat
authors.forename: Christianne J M
authors.initials: CJ
authors.lastname: de Groot
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000209:etiology; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011262:Pregnancy Trimester, Second; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics
chemical_list: D000925:Anticoagulants