title: Herpes simplex virus life cycle and the design of viral vectors.
abstract: Herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) are doublestranded DNA viruses with a genome size of 152 kbp. The genome consists of two unique regions, U(L) (long) and U(s) (short), flanked by repeated sequences (Fig. 1; for review, see ref. 1). The two viruses are closely related, and both infect humans, producing mucocutaneous sores that are predominantly facial in the case of HSV-1 and genital in the case of HSV-2.
authors.affiliation: Medical Molecular Biology Unit, University College and Middlesex School of Medicine, London, UK.
authors.forename: D S
authors.initials: DS
authors.lastname: Latchman