title: Prevalence of comorbidities and associated cardiac diseases in patients with valve aortic stenosis. Potential implications for the decision-making process.
abstract: OBJECTIVE
  Aortic valve replacement (AVR) is recommended in patients with symptomatic aortic stenosis (AS). However a large number of elderly patients remain untreated because of a high operative risk. The aim of this study was to assess the risk profile of a group of AS patients, evaluating the prevalence of comorbidities and associated cardiac diseases and their impact on therapeutic decisions.
  
  
  METHODS
  Two-hundred forty consecutive AS patients underwent complete clinical evaluation, in order to define the stenosis severity, the prevalence of several associated cardiac conditions and comorbidities. Furthermore, the treatment choices based on this approach were recorded.
  
  
  RESULTS
  Mean age was 78.6 ± 8.93 years, 75.5% was ≥ 75 years old, 60% females; 226 patients (94.2%) had symptoms and 54.2% was in NYHA classes III-IV. Valve area <1cm(2) was detected in 81.6% of patients. Both comorbidities and associated cardiac diseases were common; particularly, renal dysfunction was detected by estimated glomerular filtration rate in 52.7%, chronic obstructive lung disease in 25.4%, cerebrovascular/peripheral artery disease in 30.8% and 11.6%, respectively, diabetes in 30%, malignancies (current or previous) in 26.6% of patients. Among associated cardiac diseases, coronary artery disease was detected in 43.7%, LV systolic dysfunction in 28.7%, pulmonary hypertension in 67%, at least moderate mitral regurgitation in 32.5% and porcelain aorta in 7.5% of patients. Fourteen asymptomatic patients (pts) (5.9%) remained in follow-up, 77 (32%) underwent surgical AVR, 64 (26.7%) underwent transcatheter valve implantation, 28 (11.6%) underwent balloon valvuloplasty and 57 (23.8%), despite symptoms, remained on medical therapy alone.
  
  
  CONCLUSIONS
  Comorbidities and coexisting cardiac diseases are very common in AS and may strongly influence the decision-making process.
authors.affiliation: Section of Cardiovascular Diseases, University of Brescia, Brescia, Italy. faggiano@numerica.it
authors.forename: Pompilio
authors.initials: P
authors.lastname: Faggiano
authors.forename: Silvia
authors.initials: S
authors.lastname: Frattini
authors.forename: Valentina
authors.initials: V
authors.lastname: Zilioli
authors.forename: Andrea
authors.initials: A
authors.lastname: Rossi
authors.forename: Stefano
authors.initials: S
authors.lastname: Nistri
authors.forename: Frank L
authors.initials: FL
authors.lastname: Dini
authors.forename: Roberto
authors.initials: R
authors.lastname: Lorusso
authors.forename: Cesare
authors.initials: C
authors.lastname: Tomasi
authors.forename: Livio Dei
authors.initials: LD
authors.lastname: Cas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D015897:Comorbidity; D003657:Decision Making; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006331:Heart Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence