title: Cognitive impairment at the onset of multiple sclerosis: relationship to lesion location.
abstract: The impact of lesion location on cognitive functioning was assessed in a group of 97 patients with a clinically isolated syndrome. Using the Brief Repeatable Battery, we evidenced that 24% of patients showed at least one abnormal test, 20% at least two and 15% at least three. Verbal learning performances were inversely associated with presence of lesions in Broca's area, in the right frontal lobe and in the splenium while spatial learning performances were inversely correlated to the presence of lesions in the deep white matter. No associations were evidenced between lesion location and performance of tasks exploring attention and executive functions.
authors.affiliation: Pôle de Neurosciences Cliniques, Centre Hospitalier Universitaire Timone, 260 boulevard St Pierre, Marseille, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Reuter
authors.forename: Wafaa
authors.initials: W
authors.lastname: Zaaraoui
authors.forename: Lydie
authors.initials: L
authors.lastname: Crespy
authors.forename: Anthony
authors.initials: A
authors.lastname: Faivre
authors.forename: Audrey
authors.initials: A
authors.lastname: Rico
authors.forename: Irina
authors.initials: I
authors.lastname: Malikova
authors.forename: Sylviane
authors.initials: S
authors.lastname: Confort-Gouny
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Cozzone
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Ranjeva
authors.forename: Jean
authors.initials: J
authors.lastname: Pelletier
authors.forename: Bertrand
authors.initials: B
authors.lastname: Audoin
mesh_terms: D000328:Adult; D001288:Attention; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000523:psychology; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000523:psychology; D004185:Disability Evaluation; D056344:Executive Function; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000523:psychology; D009483:Neuropsychological Tests; D015995:Prevalence; D013116:Spinal Cord / Q000473:pathology*; D014706:Verbal Learning; D055815:Young Adult