title: Cladieunicellins A-E, new eunicellins from an Indonesian soft coral Cladiella sp.
abstract: Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung, Taiwan.
authors.forename: Yung-Husan
authors.initials: YH
authors.lastname: Chen
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Tai
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Kao
authors.forename: Jan-Jung
authors.initials: JJ
authors.lastname: Li
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009504:Neutrophils / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D013481:Superoxides