title: [Apoptosis--universal mechanisms of cell death and survival in ischemia and reperfusion: ways to pharmacological control].
abstract: Cell death is the main element of ischemic-reperfusive states. The balance of main cell death forms (necrosis and apoptosis) in impaired tissues determines the extent of cellular loss and the rate of pathological process spreading, as well as the possibility of functional recovery. The review describes triggering mechanisms of apoptosis under the ischemia-reperfusion conditions, considers the role of inflammation in limiting the cell loss and its dependence on the balance of necrotic and apoptotic forms of cell death at the site of ischemia-reperfusion, and suggests potential methods for pharmacological correction of protective potency of the cell and the balance of cell death forms.
authors.forename: A V
authors.initials: AV
authors.lastname: Savateev
authors.forename: T N
authors.initials: TN
authors.lastname: Savateeva-Liubimova
mesh_terms: D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*