title: Exhaled nitric oxide parameters and functional capacity in chronic obstructive pulmonary disease.
abstract: The extended exhaled nitric oxide (eNO) parameters, including peripheral or alveolar eNO, are investigational biomarkers in COPD. In this study, the hypothesis was tested that elevated peripheral eNO correlates with decreased functional capacity and lower global health status. Twenty-seven subjects with the Global Initiative for Chronic Obstructive Lung Disease stage 3 and 4 COPD were enrolled. Functional capacity and health status were tested using the 6 min walk test and St George's Respiratory Questionnaire (SGRQ) respectively. eNO parameters were estimated using multiple exhalation flow rates and were corrected for axial diffusion. The extended NO measurements were FE(NO)0.05 14.2 ppb (range 5.1-23.2), C(ANO) 4.6 ppb (2.2-6.9), D(awNO) 8.8 ml s(-1) (4.8-12.9), C(awNO) 83.2 ppb (29.9-128.7) and J'(awNO) 405 pl s(-1) (111-731). The distance traveled in the 6 min walk test was correlated with peripheral nitric oxide (r = -0.59, p = 0.03). SGRQ symptom score was correlated with maximum airway NO flux (r = -0.73, p = 0.01). SGRQ total score was correlated with maximum airway NO flux (r = -0.56, p = 0.05). In this study of subjects with severe COPD, peripheral nitric oxide correlated with functional capacity while large airway NO parameters correlated with symptom scores.
authors.affiliation: Rice Quantum Institute, Rice University, Houston, TX, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: McCurdy
authors.forename: Amir
authors.initials: A
authors.lastname: Sharafkhaneh
authors.forename: Hanan
authors.initials: H
authors.lastname: Abdel-Monem
authors.forename: Javier
authors.initials: J
authors.lastname: Rojo
authors.forename: Frank K
authors.initials: FK
authors.lastname: Tittel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D001944:Breath Tests / Q000379:methods*; D003430:Cross-Sectional Studies; D005080:Exercise Test; D045853:Exhalation; D005260:Female; D005541:Forced Expiratory Volume; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism*; D012129:Respiratory Function Tests; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide