title: Thrombolysis with reteplase for recurrent mechanical heartvalve thrombosis.
abstract: Thrombotic occlusion of a prosthetic valve continues to be an uncommon but life threatening complication of mechanical valves. However, recurrent prosthetic valve thrombosis is yet a rare complication. Urokinase and tissue plasminogen activator (tPA) have previously been used with success in cases of recurrent thrombus formation and/or failure of streptokinaSe treatment. We report the first three cases of recurrent prosthetic mitral valve thrombosis in Pakistan which were treated with Reteplase that resulted in re-establishment of adequate blood flow across the valve with reduction of mean gradient to normal.
authors.affiliation: Department of Cardiology, Shifa College of Medicine, Islamabad.
authors.forename: Naveed
authors.initials: N
authors.lastname: Akhtar
authors.forename: Yasser Jalil
authors.initials: YJ
authors.lastname: Khan
authors.forename: Waqas
authors.initials: W
authors.lastname: Ahmed
mesh_terms: D000328:Adult; D004452:Echocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; C087896:reteplase; D010959:Tissue Plasminogen Activator