title: Acute lymphoblastic leukemia with hyperleukocytosis, sinus pauses, and hypoxemic respiratory failure in an infant.
abstract: A 5-month-old female infant presented with new-onset acute lymphoblastic leukemia and hyperleukocytosis with white blood cell count of 352 × 10(9) cells/L. She developed sinus pauses and hypoxemic respiratory failure. A manual single volume exchange blood transfusion was done with complete resolution of sinus pauses and hypoxemia.
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Children's Hospital of New Jersey, Newark Beth Israel Medical Center, Newark, NJ 07112, USA. jsykes@sbhcs.com
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Sykes
authors.forename: Meena
authors.initials: M
authors.lastname: Kalyanaraman
authors.forename: Peri
authors.initials: P
authors.lastname: Kamalakar
authors.forename: Niti
authors.initials: N
authors.lastname: Sharma
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D004562:Electrocardiography; D005078:Exchange Transfusion, Whole Blood / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000150:complications* / Q000628:therapy; D007223:Infant; D007958:Leukocyte Count; D007964:Leukocytosis / Q000097:blood / Q000150:complications* / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000150:complications* / Q000628:therapy; D012131:Respiratory Insufficiency; D054138:Sinus Arrest, Cardiac / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents