title: Vilsmeier reaction of 3-aminopropenamides: one-pot synthesis of pyrimidin-4(3H)-ones.
abstract: A facile one-pot synthesis of pyrimidin-4(3H)-ones was developed via reactions of a series of readily available 3-aminopropenamides with varied Vilsmeier reagents, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.
authors.affiliation: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Dingyuan
authors.initials: D
authors.lastname: Zhang
authors.forename: Yongjiu
authors.initials: Y
authors.lastname: Liang
authors.forename: Guangyuan
authors.initials: G
authors.lastname: Zhou
authors.forename: Dewen
authors.initials: D
authors.lastname: Dong
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D003500:Cyclization; D006219:Halogens / Q000737:chemistry; D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000577:Amides; D006219:Halogens; D011744:Pyrimidinones; C013658:propylene