title: Direct alkylation of heteroaryls using potassium alkyl- and alkoxymethyltrifluoroborates.
abstract: A direct alkylation of various heteroaryls using stoichiometric potassium alkyl- and alkoxymethyltrifluoroborates has been developed. This method leads to the synthesis of complex substituted heterocycles, which have been obtained with yields up to 89%.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States. gmolandr@sas.upenn.edu
authors.forename: Gary A
authors.initials: GA
authors.lastname: Molander
authors.forename: Virginie
authors.initials: V
authors.lastname: Colombel
authors.forename: Valerie A
authors.initials: VA
authors.lastname: Braz
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D001881:Borates / Q000737:chemistry*; D017611:Fluorine Compounds / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D011188:Potassium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D001881:Borates; D017611:Fluorine Compounds; D005609:Free Radicals; C059688:alkoxyl radical; D011188:Potassium