title: Simple indole alkaloids from the neotropical rutaceous tree Raputia simulans.
abstract: The genus Raputia Aubl. comprises 10 neotropical species of the family Rutaceae belonging to the subtribe Cuspariinae. We report herein the investigation of the dichloromethane extract of the stem bark of R. simulans, which has led to the isolation of indole type alkaloids. The isolation procedure was performed by fast centrifugal partition chromatography (FCPC) and adsorption chromatography and afforded 11 isolates: indole-5-carbaldehyde (1), 7-prenylindole (2), 5-prenylindole (3), verticillatine B (4), 5-(but-3'-en-2'-one)indole (5), 5-(2'-methylbut-3'-en-1'-ol)indole (6), 5-[methyl-4'-(2'-methyl-4-oxobutanoate)]indole (7), 5-[4-(methyl)furan-2-yl]indole ( 8), 5-[4-(methoxymethyl)furan-2-yl]indole (9), 5-[5'-(3-methylfuran-2'(5' H)-one)]indole (10), and 5-(4'-methyl-2',5'-dihydrofuran-2'-yl)indole (11). Metabolites 5- 11 were isolated for the first time and bear uncommon substituents on position 5 of the indole moiety.
authors.affiliation: Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, University of Athens, Athens, Greece.
authors.forename: Konstantina
authors.initials: K
authors.lastname: Vougogiannopoulou
authors.forename: Nikolas
authors.initials: N
authors.lastname: Fokialakis
authors.forename: Nektarios
authors.initials: N
authors.lastname: Aligiannis
authors.forename: Charles
authors.initials: C
authors.lastname: Cantrell
authors.forename: Alexios-Leandros
authors.initials: AL
authors.lastname: Skaltsounis
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D014197:Trees / Q000737:chemistry
chemical_list: D000470:Alkaloids; D007211:Indoles; D010936:Plant Extracts; C030374:indole