title: Interferon-β but not Glatiramer acetate stimulates CXCL10 secretion in primary cultures of thyrocytes: a clue for understanding the different risks of thyroid dysfunctions in patients with multiple sclerosis treated with either of the two drugs.
abstract: Autoimmune thyroid disease (AITD) has been reported in patients with multiple sclerosis (MS) receiving interferon-beta (IFN-β), but not in those receiving Glatiramer acetate (GA). CXCL10 is a chemokine playing a pathogenetic role in AITD and MS. Our aim was to evaluate the effects on CXCL10 secretion of IFN-β and GA, alone and in combination with TNF-α, in primary cultures of thyrocytes (PCT). Significant and dose-dependent secretions of CXCL10 were induced by IFN-β but not GA. TNF-α synergistically increased IFN-β induced CXCL10 secretion. These results may provide an explanation for the occurrence of AITD during IFN-β, but not during GA, treatment for MS.
authors.affiliation: Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors and Chair of Endocrinology, University of Pavia, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Rotondi
authors.forename: Francesca
authors.initials: F
authors.lastname: Stufano
authors.forename: Maria Stefania
authors.initials: MS
authors.lastname: Lagonigro
authors.forename: Luigi
authors.initials: L
authors.lastname: La Manna
authors.forename: Francesca
authors.initials: F
authors.lastname: Zerbini
authors.forename: Stefania
authors.initials: S
authors.lastname: Ghilotti
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Pagliari
authors.forename: Francesca
authors.initials: F
authors.lastname: Coperchini
authors.forename: Flavia
authors.initials: F
authors.lastname: Magri
authors.forename: Roberto
authors.initials: R
authors.lastname: Bergamaschi
authors.forename: Antonio
authors.initials: A
authors.lastname: Oliviero
authors.forename: Luca
authors.initials: L
authors.lastname: Chiovato
mesh_terms: D000704:Analysis of Variance; D002478:Cells, Cultured; D054357:Chemokine CXCL10 / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016899:Interferon-beta / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects*
chemical_list: C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D007166:Immunosuppressive Agents; D010455:Peptides; D000068717:Glatiramer Acetate; D016899:Interferon-beta