title: Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis.
abstract: Adult neurogenesis is a sophisticated biological process whose function has remained a mystery to neuroscience researchers. To address this question, a number of unique modeling studies have explored the computational implications of adding new neurons to the adult dentate gyrus. Models of neurogenesis fall into two broad categories: abstract models that explore the function of new neurons in simple networks, and biologically based models that investigate the role of new neurons in networks based on the anatomy of the hippocampus. In this review, we summarize the strategies and results of these different modeling approaches, and we discuss their conclusions and limitations in the face of new biological findings.
authors.affiliation: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, CA 92037, USA. aimone@salk.ed
authors.forename: James B
authors.initials: JB
authors.lastname: Aimone
authors.forename: Fred H
authors.initials: FH
authors.lastname: Gage
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology*; D000818:Animals; D001519:Behavior; D003198:Computer Simulation; D008959:Models, Neurological; D009415:Nerve Net; D016571:Neural Networks, Computer; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009488:Neurosciences