title: [New concepts in the management of MIBC in 2010].
abstract: The urothelial carcinoma of the prostate is an entity which is necessary to recognize. The infiltration of the prostatic stroma is a major prognostic factor. The 2009 pTNM classification distinguish carcinoma in situ of the urethra with involvement of prostatic acini (pT2) from direct invasion of prostatic stroma through outside involvement (pT4). In case of non metastatic muscle invasive bladder cancer with major lymphatic invasion, the standard treatment remains neoadjuvant chemotherapy followed by radical cystectomy and extended lymphadenectomy. Only some patients can hope a complete response after neoadjuvant chemotherapy. For these responders, we can sometimes discuss, at an individual level, a bladder conservative strategy with an intensive surveillance.
authors.affiliation: Service d'Urologie, Hôpital Cochin, 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. gg_pignot@yahoo.fr
authors.forename: G
authors.initials: G
authors.lastname: Pignot
authors.forename: V
authors.initials: V
authors.lastname: Molinié
authors.forename: P
authors.initials: P
authors.lastname: Coloby
authors.forename: S
authors.initials: S
authors.lastname: Culine
authors.forename: G
authors.initials: G
authors.lastname: Gravis
authors.forename: D
authors.initials: D
authors.lastname: Rossi
authors.forename: C
authors.initials: C
authors.lastname: Theodore
authors.forename: M
authors.initials: M
authors.lastname: Zerbib
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*