title: Postgenomic technologies targeting the Wnt signaling network.
abstract: The recent development of high-throughput sequencing technologies and the availability of whole genome sequences of a variety of living organisms, including that of humans, have led to an enormous push in the quest for a comprehensive inquiry for the function of each and every gene discovered in different model organisms. A major conclusion from the sequencing projects was that while forward genetics had been extremely successful in identifying key genes/components of many biological processes, such as signal transduction cascades, the function(s) of the majority of genes in the genome remains a mystery. In this article, we discuss the use of a variety of high-throughput postgenomic tools, including functional genomics, proteomics, and chemical genetics that are being implemented in an exhaustive molecular dissection of a key evolutionarily conserved signal transduction pathway, namely the Wnt/wingless (wg) pathway and its associated signaling network.
authors.affiliation: Department of Pharmacology, New York University School of Medicine and NYU Cancer Institute, New York, NY, USA.
authors.forename: Raluca
authors.initials: R
authors.lastname: Pancratov
authors.forename: Ramanuj
authors.initials: R
authors.lastname: DasGupta
mesh_terms: D051177:Catenins / Q000378:metabolism; D006801:Humans; D034622:RNA Interference; D015398:Signal Transduction / Q000235:genetics*; D054852:Small Molecule Libraries / Q000737:chemistry; D051153:Wnt Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D051177:Catenins; D054852:Small Molecule Libraries; D051153:Wnt Proteins