title: [Hormonal treatment effectivity in hyperandrogenic syndrome].
abstract: OBJECTIVE
  To evaluate effectiveness of hormonal treatment of hyperandrogenic syndrome (HAS).
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic.
  
  
  METHODS
  We assessed effect of one-year-long hormonal treatment on menstrual cycles (MC), clinical signs of HAS, and ultrasound finding (USG) in 90 patients with HAS. Patients were divided into three groups with 30 females: A--35 microg ethinylestradiol (EE) with 2.0 mg cyproterone acetate/day; B--30 microg EE with 2.0 mg dienogest/day; C--30 microg EE with 3.0 mg drospirenone/day.
  
  
  RESULTS
  It was achieved a positive effect on MC regularity in every group during the first six months of treatment (p < 0.001). Signs of hirsutism, virilization, and USG finding were significantly better in group A.
  
  
  CONCLUSIONS
  The most effective hormonal treatment in our study was the combination of 35 microg EE with 2.0 mg cyproterone acetate/day.
authors.affiliation: Gynekologicko-pôrodnicka klinika JLF UK, Martin, Slovensko. visnovsky@jfmed.uniba.sk
authors.forename: J
authors.initials: J
authors.lastname: Visnovský
authors.forename: K
authors.initials: K
authors.lastname: Biringer
authors.forename: I
authors.initials: I
authors.lastname: Svecová
authors.forename: Z
authors.initials: Z
authors.lastname: Biringerová
mesh_terms: D000328:Adult; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000736:Androstenes / Q000627:therapeutic use*; D017373:Cyproterone Acetate / Q000627:therapeutic use*; D004967:Estrogens / Q000627:therapeutic use*; D004997:Ethinyl Estradiol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000188:drug therapy*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D013577:Syndrome
chemical_list: D000726:Androgen Antagonists; D000736:Androstenes; D004967:Estrogens; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; C035144:drospirenone