title: Effect of bevacizumab on postoperative adhesion formation in a rat uterine horn adhesion model and the correlation with vascular endothelial growth factor and Ki-67 immunopositivity.
abstract: We investigated whether adhesion formation is prevented by the inhibition of angiogenesis in a rat uterine horn adhesion model. A single-dose of bevacizumab was effective in preventing postoperative intraperitoneal adhesion formation among 30 Wistar albino rats that underwent serosal injury by use of a standard technique after laparotomy with intraperitoneal bevacizumab.
authors.affiliation: Department of Gynecology and Obstetrics, Ankara Zekai Tahir Burak Education and Research Hospital, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Moraloglu
authors.forename: Hatice
authors.initials: H
authors.lastname: Işik
authors.forename: Sevtap
authors.initials: S
authors.lastname: Kiliç
authors.forename: Ulaş
authors.initials: U
authors.lastname: Sahin
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Caydere
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ustün
authors.forename: Sertaç
authors.initials: S
authors.lastname: Batioglu
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000494:pharmacology*; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D019394:Ki-67 Antigen / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions; D014591:Uterine Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D014599:Uterus / Q000098:blood supply / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D019394:Ki-67 Antigen; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat; D000068258:Bevacizumab