title: Growth factor-enriched autologous plasma improves wound healing after surgical debridement in odontogenic necrotizing fasciitis: a case report.
abstract: BACKGROUND
  Odontogenic necrotizing fasciitis of the neck is a fulminant infection of odontogenic origin that quickly spreads along the fascial planes and results in necrosis of the affected tissues. It is usually polymicrobial, occurs frequently in immunocompromised patients, and has a high mortality rate.
  
  
  METHODS
  A 69-year old Mexican male had a pain in the maxillar right-canine region and a swelling of the submental and submandibular regions. Our examination revealed local pain, tachycardia, hyperthermia (39°C), and the swelling of bilateral submental and submandibular regions, which also were erythematous, hyperthermic, crepitant, and with a positive Godet sign. Mobility and third-degree caries were seen in the right mandibular canine. Bacteriological cultures isolated streptococcus pyogenes and staphylococcus aureus. The histopathological diagnosis was odontogenic necrotizing fasciitis of the submental and submandibular regions. The initial treatment was surgical debridement and the administration of antibiotics. After cultures were negative, the surgical wound was treated with a growth factor-enriched autologous plasma eight times every third day until complete healing occurred.
  
  
  CONCLUSIONS
  The treatment with a growth factor-enriched autologous plasma caused a rapid healing of an extensive surgical wound in a patient with odontogenic necrotizing fasciitis. The benefits were rapid tissue regeneration, an aesthetic and a functional scar, and the avoidance of further surgery and possible complications.
authors.affiliation: Laboratorio de Medicina Genómica, Hospital Regional "1o, de Octubre", Av, IPN No, 1669, México D, F,, C,P, 07760, México. jantgonzalez@issste.gob.mx.
authors.forename: Rubi
authors.initials: R
authors.lastname: Lopez-Fernandez
authors.forename: Jorge
authors.initials: J
authors.lastname: Ramirez-Melgoza
authors.forename: Nora Ernestina
authors.initials: NE
authors.lastname: Martinez-Aguilar
authors.forename: Alicia
authors.initials: A
authors.lastname: Leon-Chavez
authors.forename: Daniel
authors.initials: D
authors.lastname: Martinez-Fong
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Gonzalez-Barrios