title: Asymmetric Michael addition of 1-acetylindolin-3-ones to β-nitrostyrenes catalyzed by bifunctional thioureas: a simple access to 2-functionalized indoles.
abstract: The first asymmetric Michael addition of 1-acetylindolin-3-ones to β-nitrostyrenes has been developed. 2-Substituted indolin-3-one derivatives were obtained with excellent yields (up to 99%) and good stereoselectivities (up to 28:1 dr and 92% ee), which could be transformed into 2-functionalized indoles easily without racemization. This achievement might further contribute to the chemistry and pharmacology of indole-related compounds.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Yao-Zong
authors.initials: YZ
authors.lastname: Liu
authors.forename: Rui-Ling
authors.initials: RL
authors.lastname: Cheng
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Xu