title: Tropisetron and paracetamol association in post-operative patients.
abstract: Studies in animals and in healthy volunteers have demonstrated the central serotonergic analgesic mechanism of action of paracetamol involving the inhibition of this analgesia by tropisetron, a 5-HT3 antagonist. This randomized, double-blind, controlled study aims at studying this interaction in post-operative patients after ear surgery. Thirty-six patients are included in two parallel groups with intravenous paracetamol (1 g) and either tropisetron (T, 5 mg/mL) or placebo (c, NaCl 0.9%) administered at the end of surgery. Numerical pain evaluations are performed every 30 min, six times after awakening. The difference between the sums of numerical scales of both groups [9 ± 10 (T) vs. 6 ± 7 (c)] is not significant, but the tropisetron group displays higher pain scores despite additional rescue analgesia. The limits of this trial call for a much larger study to investigate further this pharmacodynamic interaction.
authors.affiliation: CHU Clermont-Ferrand, Centre de Pharmacologie Clinique, F-63003 Clermont-Ferrand, France. gisele.pickering@u-clermont1.fr
authors.forename: Gisèle
authors.initials: G
authors.lastname: Pickering
authors.forename: Michael
authors.initials: M
authors.lastname: Faure
authors.forename: Fabienne
authors.initials: F
authors.lastname: Commun
authors.forename: Elisabeth Carrier
authors.initials: EC
authors.lastname: de Boissy
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Roche
authors.forename: Thierry
authors.initials: T
authors.lastname: Mom
authors.forename: Estelle
authors.initials: E
authors.lastname: Simen
authors.forename: Claude
authors.initials: C
authors.lastname: Dubray
authors.forename: Alain
authors.initials: A
authors.lastname: Eschalier
authors.forename: Laurent
authors.initials: L
authors.lastname: Gilain
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013506:Otologic Surgical Procedures / Q000009:adverse effects; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D011446:Prospective Studies; D000077526:Tropisetron
chemical_list: D007211:Indoles; D000082:Acetaminophen; D000077526:Tropisetron