title: Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity.
abstract: Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural alkaloids.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Kitajima
authors.forename: Masumi
authors.initials: M
authors.lastname: Iwai
authors.forename: Ruri
authors.initials: R
authors.lastname: Kikura-Hanajiri
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Goda
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Iida
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Yabushita
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takayama
mesh_terms: D055808:Drug Discovery; D026121:Indole Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors*; D021241:Spectrometry, Mass, Electrospray Ionization; D036902:Voacanga / Q000737:chemistry
chemical_list: D026121:Indole Alkaloids; D010936:Plant Extracts; D043884:Receptor, Cannabinoid, CB1