title: Direct autologous bone marrow-derived stem cell transplantation for ischemic heart disease: a meta-analysis.
abstract: OBJECTIVE
  Previous evaluation of intracoronary autologous bone marrow-derived stem cell (BMSCs) therapy following ischemic heart disease (IHD) suggested improvement of cardiac functional parameters. We performed a meta-analysis to provide systematic assessment of the safety and efficacy of direct (intramyocardial or endomyocardial) BMSCs transplantation in patients with IHD.
  
  
  METHODS
  Randomized controlled Trials (RCTs) were identified in the MEDLINE (approximately Oct. 2010), the Cochrane Central Register of Controlled Trials (Central) (approximately Oct. 2010), EMBASE (approximately Oct. 2010), and EBSCO (approximately Oct. 2010), reviews, and reference lists of relevant articles. Weighted mean difference (WMD) was calculated for changes in left ventricular ejection fraction (LVEF), left ventricular end-diastolic and end-systolic volumes (LVEDV and LVESV) by using a fixed effects model.
  
  
  RESULTS
  Eight RCTs with 307 participants were eligible. Compared with controls, direct BMSCs transplantation improved LVEF (8.4%, 95% CI, 6.49 to 10.31%; p < 0.01), reduced LVESV and LVEDV (-14.85 ml, 95% CI, -27.29 to -2.41 ml, p = 0.02 and -12.79 ml, 95% CI, -24.94 to -0.65 ml, p = 0.04, respectively).
  
  
  CONCLUSIONS
  This meta-analysis suggests that direct BMSCs transplantation is associated with moderate but significant improvements over regular therapy in cardiac functional parameters in patients with IHD, and supports conducting further RCTs of a higher quality.
authors.affiliation: Nanjing University Medical School, Department of Pathology, Nanjing, China.
authors.forename: Yanting
authors.initials: Y
authors.lastname: Wen
authors.forename: Li
authors.initials: L
authors.lastname: Meng
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.forename: Jian
authors.initials: J
authors.lastname: Ouyang
mesh_terms: D006334:Heart Function Tests; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D014182:Transplantation, Autologous; D016896:Treatment Outcome