title: Targeting gastrin for the treatment of gastric acid related disorders and pancreatic cancer.
abstract: Gastrin, acting through peripheral cholecystokinin (CCK) 2 receptors, is a major hormonal regulator of gastric acid secretion. The effects of gastrin on acid secretion occur both acutely and chronically because gastrin directly stimulates gastric acid secretion and also exerts trophic effects on the enterochromaffin-like and parietal cells that together constitute the acid secretory apparatus of the stomach. Several antagonists that target the CCK2 receptor have been identified and investigated for the treatment of gastroesophageal reflux disease and pancreatic cancer. In this paper, we discuss the contribution of gastrin to these disease pathologies and the data generated to date from clinical studies investigating CCK2 receptor antagonists.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.
authors.forename: Magda
authors.initials: M
authors.lastname: Morton
authors.forename: Clodagh
authors.initials: C
authors.lastname: Prendergast
authors.forename: Terrance D
authors.initials: TD
authors.lastname: Barrett
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D019861:Enterochromaffin-like Cells / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D010295:Parietal Cells, Gastric / Q000378:metabolism; D043887:Receptor, Cholecystokinin B / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D005755:Gastrins; D043887:Receptor, Cholecystokinin B