title: Secondary pulmonary alveolar proteinosis after unrelated cord blood hematopoietic cell transplantation.
abstract: PAP is a rare alveolointerstitial lung disorder characterized histologically by the intra-alveolar accumulation of eosinophilic and PAS-positive material. We observed two cases of PAP after unrelated CB hematopoietic progenitor cell transplantation in children with ALL. No antagonist activity toward GM-CSF was identified in the patient tested. The putative multifactorial PAP etiology is discussed. This potentially curable condition should be considered in a CB allograft recipient with alveolointerstial lung disorder.
authors.affiliation: Department of Pediatrics, Hematology Unit, University Hospital Geneva, Geneva, Switzerland. marc.ansari@hcuge.ch
authors.forename: Marc
authors.initials: M
authors.lastname: Ansari
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Rougemont
authors.forename: Françoise
authors.initials: F
authors.lastname: Le Deist
authors.forename: Hulya
authors.initials: H
authors.lastname: Ozsahin
authors.forename: Michel
authors.initials: M
authors.lastname: Duval
authors.forename: Martin A
authors.initials: MA
authors.lastname: Champagne
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Fournet
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis* / Q000209:etiology