title: [Comparative study of immunomodulating properties of phenibut and gammoxin].
abstract: Experiments on CBA mice with model immunodepression induced by cyclophosphamide showed that phenibut (25 mg/kg) and gammoxin (25 mg/kg) recover both cellular and humoral immunoreactivity and restore lymphoproliferative processes in immunocompetent organs, which is evidence for pronounced immunocorrecting properties of these drugs. A comparative analysis of the immunomodulating activity of phenibut and gammoxin showed that the latter drug predominantly affects the process of immunocompetent cell maturation (growth in mass and cellularity of thymus and spleen--the central immunocompetent organs), while phenibut mostly influences the realization of the final reaction of the primary anti-erythrocyte immune response (significant correction of local infiltration delayed-type hypersensitivity reaction and antibody formation). This difference can be related to the fact that the drugs influence GABA receptors of different types, whereby gammoxin acts on these receptors in immunocompetent organs and phenibut acts on the receptors in lymphocytes.
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
authors.forename: M A
authors.initials: MA
authors.lastname: Samotrueva
authors.forename: N R
authors.initials: NR
authors.lastname: Kuleshevskaia
authors.forename: V M
authors.initials: VM
authors.lastname: Berestovitskaia
authors.forename: O S
authors.initials: OS
authors.lastname: Vasil'eva
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D018755:GABA Agonists / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects* / Q000276:immunology; D056724:Immunity, Humoral / Q000187:drug effects* / Q000276:immunology; D007155:Immunologic Factors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D018755:GABA Agonists; D007155:Immunologic Factors; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid