title: [Use of LAK-cells and systemic chemotherapy with hyperthermia in the management of chemo-resistant tumors].
abstract: Tentative results of LAK-cell and whole-body hyperthermia (WBH) were evaluated in 19 children with advanced chemorefractory tumors. LAK-cells were obtained by extracorporeal incubation of peripheral blood lymphocytes: a germ-cell rhabdomyosarcoma was detected in 4, Askin's tumor--2--2, renal cell carcinoma--2 and miscellaneous--7. Autologous LAK-cells were infused twice: on completion of WBH as body temperature fell to as low as (+) 40 deg. C and on day after WBH. The latter was well tolerated. Complete or partial response to thermochemobiotherapy was reported in 8 patients. Overall 5-year survival was 43% (median follow-up--12.6 months).
authors.forename: R S
authors.initials: RS
authors.lastname: Ismail-Zade
authors.forename: E A
authors.initials: EA
authors.lastname: Zhavrid
authors.forename: O V
authors.initials: OV
authors.lastname: Aleĭnikova
authors.forename: M P
authors.initials: MP
authors.lastname: Potapnev
authors.forename: M V
authors.initials: MV
authors.lastname: Belevtsev
authors.forename: Ia I
authors.initials: IaI
authors.lastname: Isaĭkina
authors.forename: E P
authors.initials: EP
authors.lastname: Vashkevich
authors.forename: V P
authors.initials: VP
authors.lastname: Savitskiĭ
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001831:Body Temperature; D002292:Carcinoma, Renal Cell / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced; D016219:Immunotherapy, Adoptive / Q000379:methods; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D009373:Neoplasms, Germ Cell and Embryonal / Q000628:therapy; D017599:Neuroectodermal Tumors / Q000628:therapy; D018233:Rhabdomyosarcoma, Embryonal / Q000628:therapy; D016019:Survival Analysis; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents