title: Role of β-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics.
abstract: A greater understanding of the interaction between HIV and host signaling pathways that restrict virus production may lead to new methods to purge virus from latent reservoirs and enhance survival/function of cells targeted by HIV. This review highlights the role of the Wnt/β-catenin pathway as a host factor that represses HIV replication in multiple targets, especially those relevant to HIV in the central nervous system.
authors.affiliation: Department of Immunology/Microbiology and Center for AIDS Research, Rush University Medical Center, Chicago, IL 60607, USA.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Henderson
authors.forename: Lena
authors.initials: L
authors.lastname: Al-Harthi
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D000073940:Transcription Factor 4; D014157:Transcription Factors / Q000502:physiology*; D014779:Virus Replication / Q000187:drug effects / Q000502:physiology*; D051176:beta Catenin / Q000502:physiology*
chemical_list: D019380:Anti-HIV Agents; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C532096:TCF4 protein, human; D000073940:Transcription Factor 4; D014157:Transcription Factors; D051176:beta Catenin