title: Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice.
abstract: Kisspeptin is distributed not only in brain areas for regulating reproduction but also in nuclei involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring. Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently inhibited the feeding response to an overnight fast by 50, 95, and 90% respectively, during the 2-3 h period postinjection. The 1μg/mouse dose reduced the 4-h cumulative food intake by 28% whereas intraperitoneal injection (10 μg/mouse) did not. The decreased 4-h food intake was due to reduced meal frequency (-45%/4 h), whereas meal size and gastric emptying were not altered. These data suggest that kisspeptin may be a negative central regulator of feeding by increasing satiety.
authors.affiliation: CURE/Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, VA Greater Los Angeles Health Care System, California, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Stengel
authors.forename: Lixin
authors.initials: L
authors.lastname: Wang
authors.forename: Miriam
authors.initials: M
authors.lastname: Goebel-Stengel
authors.forename: Yvette
authors.initials: Y
authors.lastname: Taché
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D059648:Kisspeptins; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D025521:Tumor Suppressor Proteins / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: C491407:Kiss1 protein, mouse; D059648:Kisspeptins; D025521:Tumor Suppressor Proteins