title: Experimental validation of a new integrated simulated moving bed process for the production of single enantiomers.
abstract: A new integrated 3-zone simulated moving bed (SMB) concept with internal racemization reaction was suggested recently for the production of single enantiomers from racemic mixtures [1,2]. The process utilizes an internal gradient to trigger the racemization within a single zone. It can deliver the pure enantiomer and outperforms conventional technologies. In this contribution, the concept is validated experimentally for the separation of a model system compound. The results demonstrate that the new concept is capable of producing a single enantiomer with purity, yield and conversion of 100%.
authors.affiliation: Max-Planck-Institut für Dynamik komplexer technischer Systeme, D-39106 Magdeburg, Germany.
authors.forename: Javier García
authors.initials: JG
authors.lastname: Palacios
authors.forename: Bernhard
authors.initials: B
authors.lastname: Kramer
authors.forename: Achim
authors.initials: A
authors.lastname: Kienle
authors.forename: Malte
authors.initials: M
authors.lastname: Kaspereit
mesh_terms: D000327:Adsorption; D000465:Algorithms; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D015203:Reproducibility of Results; D013237:Stereoisomerism