title: Alveolar bone level is not associated with vitamin D receptor gene polymorphism and bone density in mandible.
abstract: The objective of this study was to determine, using digital panoramic radiographs, whether the bone level at the alveolar crest is related to the mandibular bone density and/or to vitamin D receptor (VDR) gene polymorphisms. We analyzed 319 digital panoramic radiographs from the same number of patients. Alveolar bone level was expressed as percentage of root length. The mandibular cortical width index was calculated as a measure of mandibular bone density, and, in 72 randomly selected cases, the haplotype of the VDR gene (BsmL) was determined by polymerase chain reaction. Alveolar bone level was not related to the mandibular cortical width index (p = 0.568) or VDR gene expression (p = 0.575). Bone loss was greater in smokers than in non-smokers (p = 0.036), and the mandibular cortical width index was higher in males (p = 0.04), the older age group (p = 0.032), and in those with more teeth (p = 0.01). Multivariate analysis confirmed the association between these variables and alveolar bone loss. Alveolar bone loss showed no significant relationship with the mandibular bone density evaluated on digital panoramic radiographs or with VDR genotype (BsmL) in Caucasian females and males aged under 47 years.
authors.affiliation: Department of Periodontics, School of Dentistry, University of Granada, Granada, Spain. fmesa@ugr.es
authors.forename: Francisco
authors.initials: F
authors.lastname: Mesa
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gonzalez
authors.forename: Nizar
authors.initials: N
authors.lastname: Souki
authors.forename: Pablo
authors.initials: P
authors.lastname: Galindo-Moreno
authors.forename: Asunción
authors.initials: A
authors.lastname: Olmo
authors.forename: Francisco
authors.initials: F
authors.lastname: O'Valle
authors.forename: Manuel
authors.initials: M
authors.lastname: Bravo
mesh_terms: D000328:Adult; D000367:Age Factors; D000483:Alleles; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging; D000539:Alveolar Process / Q000000981:diagnostic imaging*; D015519:Bone Density / Q000502:physiology*; D002508:Cephalometry / Q000379:methods; D003817:Dentition; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D005260:Female; D006239:Haplotypes / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D019252:Radiography, Dental, Digital; D011862:Radiography, Panoramic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012737:Sex Factors; D012907:Smoking; D019227:Tooth Apex / Q000000981:diagnostic imaging; D019237:Tooth Cervix / Q000000981:diagnostic imaging; D014092:Tooth Root / Q000000981:diagnostic imaging; D055815:Young Adult
chemical_list: D018167:Receptors, Calcitriol; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific