title: Paper 5: Surveillance of multiple congenital anomalies: implementation of a computer algorithm in European registers for classification of cases.
abstract: BACKGROUND
  Surveillance of multiple congenital anomalies is considered to be more sensitive for the detection of new teratogens than surveillance of all or isolated congenital anomalies. Current literature proposes the manual review of all cases for classification into isolated or multiple congenital anomalies.
  
  
  METHODS
  Multiple anomalies were defined as two or more major congenital anomalies, excluding sequences and syndromes. A computer algorithm for classification of major congenital anomaly cases in the EUROCAT database according to International Classification of Diseases (ICD)v10 codes was programmed, further developed, and implemented for 1 year's data (2004) from 25 registries. The group of cases classified with potential multiple congenital anomalies were manually reviewed by three geneticists to reach a final agreement of classification as "multiple congenital anomaly" cases.
  
  
  RESULTS
  A total of 17,733 cases with major congenital anomalies were reported giving an overall prevalence of major congenital anomalies at 2.17%. The computer algorithm classified 10.5% of all cases as "potentially multiple congenital anomalies". After manual review of these cases, 7% were agreed to have true multiple congenital anomalies. Furthermore, the algorithm classified 15% of all cases as having chromosomal anomalies, 2% as monogenic syndromes, and 76% as isolated congenital anomalies. The proportion of multiple anomalies varies by congenital anomaly subgroup with up to 35% of cases with bilateral renal agenesis.
  
  
  CONCLUSIONS
  The implementation of the EUROCAT computer algorithm is a feasible, efficient, and transparent way to improve classification of congenital anomalies for surveillance and research.
authors.affiliation: Paediatric Department, Hospital Lillebaelt, Kolding, Denmark. ester.garne@slb.regionsyddanmark.dk
authors.forename: Ester
authors.initials: E
authors.lastname: Garne
authors.forename: Helen
authors.initials: H
authors.lastname: Dolk
authors.forename: Maria
authors.initials: M
authors.lastname: Loane
authors.forename: Diana
authors.initials: D
authors.lastname: Wellesley
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Barisic
authors.forename: Elisa
authors.initials: E
authors.lastname: Calzolari
authors.forename: James
authors.initials: J
authors.lastname: Densem
mesh_terms: D000015:Abnormalities, Multiple / Q000145:classification* / Q000453:epidemiology; D000465:Algorithms; D005260:Female; D006801:Humans; D011159:Population Surveillance; D011247:Pregnancy; D015995:Prevalence; D012042:Registries / Q000706:statistics & numerical data*