title: Total synthesis of (±)-meloscine.
abstract: The total synthesis of (±)-meloscine was completed in a highly stereoselective manner starting from the known 4-(2-aminophenyl)-2,3-dihydro-N-methoxycarbonylpyrrole. The crucial step in this total synthesis involves the efficient construction of the tetracyclic framework of the target natural product by the intramolecular Pauson-Khand reaction.
authors.affiliation: Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Inagaki
authors.forename: Chisato
authors.initials: C
authors.lastname: Mukai
mesh_terms: D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D011804:Quinolines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D011083:Polycyclic Compounds; D011804:Quinolines; C530682:meloscine