title: C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.
abstract: The total synthesis of C(20)-trifluoro-6(E),8(Z),11(Z),14(Z) 5-oxo-ETE is reported. This compound was designed as an ω-oxidation-resistant analog of 5-oxo-ETE that would be resistant to metabolism. The trifluoro derivative of 5-oxo-ETE stimulated calcium mobilization in neutrophils and desensitized these cells to subsequent exposure to 5-oxo-ETE.
authors.affiliation: Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 West University Boulevard, Melbourne, FL 32901, USA.
authors.forename: Pranav
authors.initials: P
authors.lastname: Patel
authors.forename: Vivek
authors.initials: V
authors.lastname: Gore
authors.forename: William S
authors.initials: WS
authors.lastname: Powell
authors.forename: Joshua
authors.initials: J
authors.lastname: Rokach
mesh_terms: D001095:Arachidonic Acids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D010084:Oxidation-Reduction; D013050:Spectrometry, Fluorescence
chemical_list: D001095:Arachidonic Acids