title: Accelerated T2 mapping for characterization of prostate cancer.
abstract: Prostate T(2) mapping was performed in 34 consecutive patients using an accelerated multiecho spin-echo sequence with 4-fold k-space undersampling leading to a net acceleration factor of 3.3 on a 3T scanner. The mean T(2) values from the accelerated and conventional, unaccelerated sequences demonstrated a very high correlation (r = 0.99). Different prostate segments demonstrated similarly good interscan reproducibility (p = not significant) with slightly larger difference at base: 2.0% ± 1.6% for left base and 2.1% ± 1.1% for right base. In patients with subsequent targeted biopsy, T(2) values of histologically proven malignant tumor areas were significantly lower than the suspicious looking but nonmalignant lesions (p < 0.05) and normal areas (p < 0.001): 100 ± 10 ms for malignant tumors, 114 ± 23 ms for suspicious lesions and 149 ± 32 ms for normal tissues. The proposed method can provide an effective approach for accelerated T(2) quantification for prostate patients.
authors.affiliation: Philips Research North America, Briarcliff Manor, New York, USA. wei.liu2.ctr@us.army.mil
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Baris
authors.initials: B
authors.lastname: Turkbey
authors.forename: Julien
authors.initials: J
authors.lastname: Sénégas
authors.forename: Stefanie
authors.initials: S
authors.lastname: Remmele
authors.forename: Sheng
authors.initials: S
authors.lastname: Xu
authors.forename: Jochen
authors.initials: J
authors.lastname: Kruecker
authors.forename: Marcelino
authors.initials: M
authors.lastname: Bernardo
authors.forename: Bradford J
authors.initials: BJ
authors.lastname: Wood
authors.forename: Peter A
authors.initials: PA
authors.lastname: Pinto
authors.forename: Peter L
authors.initials: PL
authors.lastname: Choyke
mesh_terms: D000368:Aged; D001706:Biopsy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D015203:Reproducibility of Results
chemical_list: D017430:Prostate-Specific Antigen