title: Protective role of Pleurotus porrigens (Angel's wings) against gentamicin-induced nephrotoxicty in mice.
abstract: OBJECTIVE
  This study was conducted to quantitatively evaluate the recovery effects of methanolic fraction Angel's wings on gentamicin (GM)-induced nephrotoxicity.
  
  
  METHODS
  Renal injury was achieved by injecting 100 mg/kg, intraperitoneally of GM in normal saline. Extract were administrated intraperitoneally at doses 200 and 400 mg/kg. Blood samples were examined for serum creatinine, serum urea, and blood urea nitrogen after the 10 consecutive days of treatment.
  
  
  RESULTS
  Results show that GM-induced nephrotoxic animal model was successfully prepared. Methanolic fraction of Angel's wings attenuated the gentamicin-induced increase in level of serum creatinine, serum urea, and blood urea nitrogen.
  
  
  CONCLUSIONS
  The present study shows that the extract at the doses 200 and 400 mg/kg, intraperitoneally offered significant nephroprotective action that is comparable with control group.
authors.affiliation: Department of Biology, University of Mazandaran, Babolsar, Iran.
authors.forename: A Hajizadeh
authors.initials: AH
authors.lastname: Moghaddam
authors.forename: M
authors.initials: M
authors.lastname: Javaheri
authors.forename: S F
authors.initials: SF
authors.lastname: Nabavi
authors.forename: M R
authors.initials: MR
authors.lastname: Mahdavi
authors.forename: S M
authors.initials: SM
authors.lastname: Nabavi
authors.forename: M A
authors.initials: MA
authors.lastname: Ebrahimzadeh
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D005839:Gentamicins; D007274:Injections, Intraperitoneal; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D020076:Pleurotus; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014508:Urea / Q000097:blood
chemical_list: D015415:Biomarkers; D005839:Gentamicins; D010936:Plant Extracts; D020011:Protective Agents; D014508:Urea; D003404:Creatinine