title: Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can).
abstract: OBJECTIVE
  To investigate metabolic factors and their possible impact on risk of thyroid cancer.
  
  
  METHODS
  A prospective cohort study was conducted based on seven population-based cohorts in Norway, Austria, and Sweden, in the Metabolic syndrome and Cancer project (Me-Can). Altogether 578,700 men and women with a mean age of 44.0 years at baseline were followed for on average 12.0 years. Relative risk of incident thyroid cancer was assessed by levels of BMI, blood pressure, and blood levels of glucose, cholesterol, triglycerides, and by a combined metabolic syndrome (MetS) score. Risk estimates were investigated for quintiles, and a z score distribution of exposures was analyzed using Cox proportional hazards regression.
  
  
  RESULTS
  During follow-up, 255 women and 133 men were diagnosed with thyroid cancer. In women, there was an inverse association between glucose and thyroid cancer risk, with adjusted RR: 95% CI was 0.61 (0.41-0.90), p trend = 0.02 in the fifth versus the first quintile, and a positive association between BMI and thyroid cancer risk with a significant trend over quintiles. There was no association between the other metabolic factors, single or combined (Met-S), and thyroid cancer.
  
  
  CONCLUSIONS
  In women, BMI was positively, while blood glucose levels were inversely, associated with thyroid cancer.
authors.affiliation: Department of Surgery, Skåne University Hospital Lund and Lund University, 221 85 Lund, Sweden. martin.almquist@med.lu.se
authors.forename: Martin
authors.initials: M
authors.lastname: Almquist
authors.forename: Dorthe
authors.initials: D
authors.lastname: Johansen
authors.forename: Tone
authors.initials: T
authors.lastname: Björge
authors.forename: Hanno
authors.initials: H
authors.lastname: Ulmer
authors.forename: Björn
authors.initials: B
authors.lastname: Lindkvist
authors.forename: Tanja
authors.initials: T
authors.lastname: Stocks
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Anders
authors.initials: A
authors.lastname: Engeland
authors.forename: Kilian
authors.initials: K
authors.lastname: Rapp
authors.forename: Håkan
authors.initials: H
authors.lastname: Jonsson
authors.forename: Randi
authors.initials: R
authors.lastname: Selmer
authors.forename: Guenter
authors.initials: G
authors.lastname: Diem
authors.forename: Christel
authors.initials: C
authors.lastname: Häggström
authors.forename: Steinar
authors.initials: S
authors.lastname: Tretli
authors.forename: Pär
authors.initials: P
authors.lastname: Stattin
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
mesh_terms: D000328:Adult; D001317:Austria / Q000453:epidemiology; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology* / Q000378:metabolism*; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D013964:Thyroid Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol