title: Impact of Acute Hepatitis A Virus (HAV) Infection on HIV Viral Load in HIV-Infected Patients and Influence of HIV Infection on Acute HAV Infection.
abstract: OBJECTIVE
  To assess the effect of hepatitis A virus (HAV) infection on HIV viral load (VL) and the influence of HIV on the clinical expression of HAV infection.
  
  
  METHODS
  Single-center study of 23 HIV-positive patients and 41 HIV-negative patients diagnosed with acute HAV infection during 2008-2009. The impact of HAV on HIV VL was defined as an increase of >0.5 log(10) during the event, or a detectable VL for those previously suppressed patients.
  
  
  RESULTS
  The impact of acute HAV on VL was observed in 37.5% patients. HIV-negative patients were younger (27 vs 34 years, P < .0001), and serum transaminases levels normalized earlier than in the HIV-positive patients (121 vs 178 days, P < .05).
  
  
  CONCLUSIONS
  Acute HAV infection may have an impact on HIV VL. The interactions between the 2 viruses may not only prolong the HAV viremia, with a potential increase in the transmission of infection, but the impact on HIV may increase the risk of HIV transmission. Studies with higher sample size are needed to confirm our results.
authors.affiliation: Unidad de Gestión Clínica de Enfermedades Infecciosas, Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gallego
authors.forename: M
authors.initials: M
authors.lastname: Robles
authors.forename: R
authors.initials: R
authors.lastname: Palacios
authors.forename: J
authors.initials: J
authors.lastname: Ruiz
authors.forename: E
authors.initials: E
authors.lastname: Nuño
authors.forename: M
authors.initials: M
authors.lastname: Márquez
authors.forename: R
authors.initials: R
authors.lastname: Andrade
authors.forename: J
authors.initials: J
authors.lastname: Santos
mesh_terms: D015658:HIV Infections / Q000821:virology; D006506:Hepatitis A; D030041:Hepatitis A virus; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load; D014766:Viremia
chemical_list: D012367:RNA, Viral