title: Myelodysplastic syndrome with Ph negative monosomy 7 chromosome following transient bone marrow dysplasia during imatinib treatment for chronic myeloid leukemia.
abstract: We describe a 60-year-old Japanese patient with chronic myeloid leukemia (CML) who developed myelodysplastic syndrome (MDS) with Ph negative monosomy 7 chromosome following transient bone marrow dysplasia during imatinib treatment. Most cases that developed chromosomal abnormality in Ph negative cells during imatinib therapy were reported to have less clinical implications, while rare cases developed MDS/AML. The present case suggested that metaphase karyotype analysis and bone marrow examination should be performed for the long term follow-up under imatinib treatment in cases showing cytopenia. The results also suggested that monosomy 7 in Ph negative cells may be an indicator of a poor prognosis.
authors.affiliation: Division of Hematology, Niigata University Medical and Dental Hospital, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Karimata
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Masuko
authors.forename: Takashi
authors.initials: T
authors.lastname: Ushiki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kozakai
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Shibasaki
authors.forename: Toshio
authors.initials: T
authors.lastname: Yano
authors.forename: Takashi
authors.initials: T
authors.lastname: Abe
authors.forename: Masato
authors.initials: M
authors.lastname: Moriyama
authors.forename: Ken
authors.initials: K
authors.lastname: Toba
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Furukawa
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001549:Benzamides; D001853:Bone Marrow / Q000473:pathology; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D000068877:Imatinib Mesylate; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000209:etiology* / Q000235:genetics* / Q000473:pathology; D010879:Piperazines / Q000009:adverse effects*; D011743:Pyrimidines / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate