title: Effect of aging on macular features of X-linked retinoschisis assessed with optical coherence tomography.
abstract: OBJECTIVE
  X-linked retinoschisis (XLRS) is one of the most common causes of macular degeneration in young men. The purpose of this study was to use optical coherence tomography combined with ophthalmoscopy to study the effects of aging on the morphologic changes associated with XLRS.
  
  
  METHODS
  Twenty-five eyes of 17 men with XLRS ranging in age from 3 years to 68 years were studied using ophthalmoscopy and optical coherence tomography. Optical coherence tomography was used to measure macular thickness and to evaluate XLRS-related structural changes. Correlation analyses between the findings and patients' age and visual acuity were performed.
  
  
  RESULTS
  Mean visual acuity was 20/100 (range, 20/40 to 20/400). There were no correlations between visual acuity and age or macular thickness. However, there was a significant decrease in macular thickness with age (P < 0.01). Eyes with posterior vitreous detachment had significantly decreased central foveal thickness (P < 0.001). Various retinal morphologic changes could be identified by optical coherence tomography, including epiretinal membranes, intraretinal cysts, tissue pillars bridging the schisis cavities, and tissue hyperreflectivity in collapsed XLRS. These findings were significantly correlated with age.
  
  
  CONCLUSIONS
  Optical coherence tomography revealed various retinal morphologic changes associated with XLRS. These changes were correlated with age but not with visual acuity. Younger patients showed cystic retinal elevation, whereas older patients showed collapsed retinoschisis with retinal thinning.
authors.affiliation: Schepens Retina Associates Foundation, Boston, Massachusetts, USA. marcel.menke@gmail.com
authors.forename: Marcel N
authors.initials: MN
authors.lastname: Menke
authors.forename: Gilbert T
authors.initials: GT
authors.lastname: Feke
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Hirose
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D012160:Retina / Q000473:pathology*; D041441:Retinoschisis / Q000175:diagnosis* / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology