title: Purification and Characterization of Human Serum and Secretory IgA1 and IgA2 Using Jacalin.
abstract: Human immunoglobulin A (IgA) is found in serum and secretions in several different forms (1), Serum IgA is produced by the bone marrow and is pre-dominately monomeric (M ( r )= 160 kDa). Most of the IgA in secretions (sIgA) is polymeric, predominantly dimeric, comprising two monomer subunits linked together by intersubunit disulfide bonds and a cysteine-rich polypeptide termed J-chain (M ( r )= 16 kDa). Polymeric IgA in secretions, but not in serum, contains an additional heavily glycosylated protein called secretory component (SC) (M ( r )= 70 kDa).
authors.affiliation: Department of Pathology, Ninewells Hospital Medical School, University oJ Dundee, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Kerr
authors.forename: L M
authors.initials: LM
authors.lastname: Loomes
authors.forename: B C
authors.initials: BC
authors.lastname: Bonner
authors.forename: A B
authors.initials: AB
authors.lastname: Hutchings
authors.forename: B W
authors.initials: BW
authors.lastname: Senior