title: Comparative study of serum/plasma glycation and lipid peroxidation of young patients with type 1 diabetes mellitus in relation to glycemic compensation and the occurrence of diabetic complications.
abstract: OBJECTIVE
  We tried to investigate whether the AGEs in serum and lipoperoxides (LPO) monitoring were suitable for an early prediction of diabetic complications (DC) development in diabetological practice. We wanted to find whether it is better to divide the file according to the presence of DC or in terms of glycemic compensation in this study.
  
  
  METHODS
  79 diabetic patients with duration of disease for at least 5 years were divided in respect to DC presence/absence and also to long-time glycemic compensation. HbA1c was measured by LPLC in fair capillary blood, s-AGEs were estimated spectrofluorimetrically and LPO iodimetrically and spectrophotometrically in serum.
  
  
  RESULTS
  HbA1c, s-AGEs and LPO were significantly higher in the group with DC (+DC) vs. controls and also in -DC vs. controls. HbA1c and s-AGEs were significantly higher in +DC vs. patients without DC (-DC). HbA1c, s-AGEs and LPO were significantly higher in patients with poor glycemic compensation (PGC) compared to controls and HbA1c and LPO in patients with good glycemic compensation (GGC) compared to controls. HbA1c and s-AGEs were significantly higher in PGC vs. GGC. In the group of GGC we have found interesting significant correlations of HbA1c with HDL (r=0.451, p<0.05) and with LDL (r=-0.450, p<0.05).
  
  
  CONCLUSIONS
  Our findings suggest that the monitoring of s-AGEs in poorly compensated diabetic patients and LPO in all may be very useful to recognize the risk of complications. The dividing of patient file in terms of long time glycemic compensation is more reliable for research of this issue (Tab. 3, Fig. 6, Ref. 41). Full Text in free PDF www.bmj.sk.
authors.affiliation: 1st Department of Pediatrics, Faculty of Medicine, Comenius University and University Hospital for Children, Bratislava, Slovakia. j.kostolanska@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Kostolanska
authors.forename: V
authors.initials: V
authors.lastname: Jakus
authors.forename: L
authors.initials: L
authors.lastname: Barak
authors.forename: A
authors.initials: A
authors.lastname: Stanikova
authors.forename: I
authors.initials: I
authors.lastname: Waczulikova
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis*; D048909:Diabetes Complications / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D006442:Glycated Hemoglobin / Q000032:analysis; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced