title: 1α,25-Dihydroxyvitamin D3-3β-bromoacetate, a potential cancer therapeutic agent: synthesis and molecular mechanism of action.
abstract: Synthesis of 1α,25-dihydroxyvitamin D(3)-3β-bromoacetate (1,25(OH)(2)D(3)-3-BE), a potential anti-cancer agent is presented. We also report that mechanism of action of 1,25(OH)(2)D(3)-3-BE may involve reduction of its catabolism, as evidenced by the reduced and delayed expression of 1α,25-dihydroxyvitamin D(3)-24-hydroxylase (CYP24) gene in cellular assays.
authors.affiliation: Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. bapi@bu.edu
authors.forename: Rahul
authors.initials: R
authors.lastname: Ray
authors.forename: James R
authors.initials: JR
authors.lastname: Lambert
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009369:Neoplasms / Q000188:drug therapy*; D012485:Salmonella typhi / Q000187:drug effects; D013250:Steroid Hydroxylases / Q000737:chemistry / Q000378:metabolism; D065668:Vitamin D3 24-Hydroxylase
chemical_list: C104313:1,25-dihydroxyvitamin D3-3-bromoacetate; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D013250:Steroid Hydroxylases; D065668:Vitamin D3 24-Hydroxylase; D002117:Calcitriol