title: The elimination of free radicals in irradiated UHMWPEs with and without vitamin E stabilization by annealing under pressure.
abstract: Radiation crosslinking of ultrahigh molecular weight polyethylene (UHMWPE) has been used to decrease the wear of joint implant bearing surfaces. While radiation crosslinking has been successful in decreasing femoral head penetration into UHMWPE acetabular liners in vivo, postirradiation thermal treatment of the polymer is required to ensure the oxidative stability of joint implants in the long term. Two types of thermal treatment have been used: (i) annealing below the melting point preserves the mechanical properties but the residual free radicals trapped in the crystalline regions are not completely eliminated, leading to oxidation in the long-term and (ii) annealing above the melting point (melting) eliminates the free radicals but leads to a decrease in mechanical properties through loss of crystallinity during the melting process. In this study, we hypothesized that free radicals could be reduced by annealing below the melting point under pressure effectively without melting due to the elevation of the melting point. By avoiding the complete melting of UHMWPE, mechanical properties would be preserved. Our hypothesis tested positive in that we found the radiation-induced free radicals to be markedly reduced (below the detection limit of state-of-the-art electron spin resonance) by thermal annealing under pressure in radiation crosslinked virgin UHMWPE and UHMWPE/vitamin-E blends without loss of mechanical properties.
authors.affiliation: Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Ebru
authors.initials: E
authors.lastname: Oral
authors.forename: Bassem W
authors.initials: BW
authors.lastname: Ghali
authors.forename: Orhun K
authors.initials: OK
authors.lastname: Muratoglu
mesh_terms: D005609:Free Radicals / Q000737:chemistry*; D006622:Hip Prosthesis; D006801:Humans; D008422:Materials Testing / Q000379:methods; D011095:Polyethylenes / Q000737:chemistry*; D011312:Pressure; D014810:Vitamin E / Q000737:chemistry*
chemical_list: D005609:Free Radicals; D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene; D014810:Vitamin E