title: Specific interaction between Ca2+ and anionic lipids in cancer cells along with apoptosis.
abstract: Markedly inhibitory effects of Ca(2+) on the growth of human tumor cells were attained through the induction of apoptosis in vitro. On the other hand, a good correlation between the growth inhibition effects of Ca(2+) and the amounts of phosphatidylserines (PS) in the cell membranes (plasma membranes) was obtained. Furthermore, the decrease of membrane fluidity and the localization of lipid microdomains "lipid rafts" in the cell membranes were observed in the presence of Ca(2+). The findings in this study suggest that Ca(2+) could induce apoptosis toward tumor cells through the localization of lipid rafts in plasma membranes by the specific interactions between extracellular Ca(2+) and PS.
authors.affiliation: Division of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto 860–0082, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Goto
authors.forename: Kazuki
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nagata
authors.forename: Yuji
authors.initials: Y
authors.lastname: Komizu
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ueoka
mesh_terms: D000838:Anions / Q000378:metabolism; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008560:Membrane Fluidity / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D010718:Phosphatidylserines / Q000378:metabolism*; D014131:Trace Elements / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000838:Anions; D000970:Antineoplastic Agents; D010718:Phosphatidylserines; D014131:Trace Elements; D002118:Calcium