title: Development of Female Contraceptive Vaccine Through DNA Inoculation of Human Chorionic Gonadotropin Beta Subunit (hCGß).
abstract: Human chorionic gonadotropin (hCG) has been considered as a primary target molecule for a contraceptive vaccine by the World Health Organization because of its physiological and temporal specificity. hCG is an essential factor for the successful implantation and establishment of early pregnancy. For a decade, the most advanced works in development of a contraceptive vaccine have been concentrated on polypeptide based vaccines targeted directly against hCG. Although many studies have reached the stage of clinical testing using a number of prototype vaccines based on different parts of hCG molecule, their efficacy has been disappointing (1-4).
authors.affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: F C
authors.initials: FC
authors.lastname: Zhang
authors.forename: N
authors.initials: N
authors.lastname: Wang
authors.forename: D M
authors.initials: DM
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Jian
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Chen
authors.forename: X Z
authors.initials: XZ
authors.lastname: Shen
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Cao
authors.forename: B
authors.initials: B
authors.lastname: Wang