title: [Genetic counseling in osteodystrophy Albright's syndrome. Part II. GNAS1 gene and encoded protein function, genetic forecast and treatment].
abstract: In this article we describe localization and structure of genes from GNAS1 cluster, which mutations are responsible for characteristic group of features described mainly as Albright's syndrome. We present the capabilities of expressions of different phenotypes depending on types of molecular changes and possibilities of genetic prognosis with problems need to be solved in interdisciplinary support.
authors.affiliation: Studenckie Koło Naukowe przy Zakładzie Genetyki Klinicznej Uniwersytetu Medycznego w Białymstoku.
authors.forename: Leszek
authors.initials: L
authors.lastname: Janusz
authors.forename: Justyna
authors.initials: J
authors.lastname: Morawska
authors.forename: Ewa
authors.initials: E
authors.lastname: Wasilewska
authors.forename: Stanisław
authors.initials: S
authors.lastname: Sierakowski
authors.forename: Alina T
authors.initials: AT
authors.lastname: Midro
mesh_terms: D000818:Animals; D002864:Chromogranins; D004195:Disease Models, Animal; D005359:Fibrous Dysplasia, Polyostotic / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000737:chemistry* / Q000235:genetics*; D005817:Genetic Counseling; D006801:Humans; D015394:Molecular Structure; D009154:Mutation; D010641:Phenotype; D011110:Polymorphism, Genetic; D011379:Prognosis; D011547:Pseudohypoparathyroidism
chemical_list: D002864:Chromogranins; C406732:GNAS protein, human; C498642:Gnas protein, mouse; D019205:GTP-Binding Protein alpha Subunits, Gs