title: Functional roles of osteoactivin in normal and disease processes.
abstract: Osteoactivin (OA) protein was discovered in bone cells a decade ago. Recent literature suggests that osteoactivin is crucial for the differentiation and functioning of different cell types, including bone-forming osteoblasts and bone-resorbing osteoclast cells. Here, we review the literature to date on various regulatory functions of osteoactivin, as well as its discovery, structure, expression, and function in different tissues and cells. The transcriptional regulation of osteoactivin and its mechanism of action in normal and diseased conditions with special emphasis on bone are also covered in this review. In addition, we touch on the therapeutic potential of osteoactivin in cancer and bone diseases.
authors.affiliation: Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA.
authors.forename: Maneet
authors.initials: M
authors.lastname: Singh
authors.forename: Fabiola
authors.initials: F
authors.lastname: Del Carpio-Cano
authors.forename: Joyce Y
authors.initials: JY
authors.lastname: Belcher
authors.forename: Kevin
authors.initials: K
authors.lastname: Crawford
authors.forename: Nagat
authors.initials: N
authors.lastname: Frara
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Owen
authors.forename: Steven N
authors.initials: SN
authors.lastname: Popoff
authors.forename: Fayez F
authors.initials: FF
authors.lastname: Safadi
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D005136:Eye Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008099:Liver / Q000502:physiology; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D009369:Neoplasms / Q000503:physiopathology; D011499:Protein Processing, Post-Translational; D040681:Structural Homology, Protein
chemical_list: D005136:Eye Proteins; C503042:GPNMB protein, human; C445671:Gpnmb protein, mouse; C503043:Gpnmb protein, rat; D008562:Membrane Glycoproteins