title: Adhesion of biocompatible and biodegradable micropatterned surfaces.
abstract: We studied the effects of pillar dimensions and stiffness of biocompatible and biodegradable micropatterned surfaces on adhesion on different compliant substrates. The micropatterned adhesives were based on biocompatible polydimethylsiloxane (PDMS) and biodegradable poly(lactic-co-glycolic) acid (PLGA) polymer systems. Micropatterned and non-patterned compliant PDMS did not show significant differences in adhesion on compliant mice ear skin or on gelatin-glycerin model substrates. However, adhesion measurements for micropatterned stiff PLGA on compliant gelatin-glycerin model substrates showed significant enhancement in pull-off strengths compared to non-patterned controls.
authors.affiliation: Functional Surfaces Group, Campus D2 2, Leibniz Institute for New Materials, Saarbrücken, Germany.
authors.forename: Jessica S
authors.initials: JS
authors.lastname: Kaiser
authors.forename: Marleen
authors.initials: M
authors.lastname: Kamperman
authors.forename: Emerson J
authors.initials: EJ
authors.lastname: de Souza
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schick
authors.forename: Eduard
authors.initials: E
authors.lastname: Arzt
mesh_terms: D020341:Absorbable Implants; D000268:Adhesiveness; D000818:Animals; D001672:Biocompatible Materials; D002448:Cell Adhesion; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D055119:Elastic Modulus; D005780:Gelatin / Q000737:chemistry; D005990:Glycerol / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D009225:Myringoplasty; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012879:Skin Physiological Phenomena; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C013830:baysilon; D005780:Gelatin; D005990:Glycerol