title: Dibenzocyclooctadiene lignans with antineurodegenerative potential from Kadsura ananosma.
abstract: Fourteen new dibenzocyclooctadiene lignans, ananolignans A-N (1-14), together with five known compounds, were isolated from the seeds of Kadsura ananosma. The structures and absolute configurations of 1-14 were established using a combination of spectroscopic methods including 1D- and 2D-NMR and CD techniques. The biological activity of the isolated lignans was evaluated, and ananolignan F (6) and ananolignan L (12) showed significant neuroprotective effects in an in vitro assay.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Yang
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Wen
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Xi-Can
authors.initials: XC
authors.lastname: Tang
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000032:analysis / Q000737:chemistry; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D012639:Seeds / Q000737:chemistry
chemical_list: D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal; D017705:Lignans; D018696:Neuroprotective Agents; C560138:ananolignan F; C560139:ananolignan L; C510994:dibenzocyclooctadiene lignan