title: Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents.
abstract: A series of 3-phenylcoumarins were synthesized and screened for potential antidepressant activity by tail suspension test (TST) in mice. Three compounds (6, 7 and 13) exhibited impressive antidepressant activity, measured in terms of percentage decrease in immobility duration (% DID). In addition, the active antidepressant compounds were subsequently studied at their most effective dose and activity of these compounds were confirmed in forced swimming test (FST) animal model, in which the compounds at a low dose of 0.5 mg/kg significantly decreased the immobility time and exhibited greater efficacy than the reference standards fluoxetine and imipramine. The potent compounds did not show any neurotoxicity in the rotarod test and the preliminary results are promising enough to warrant further studies around this scaffold.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India. sashidhar123@gmail.com
authors.forename: Koneni V
authors.initials: KV
authors.lastname: Sashidhara
authors.forename: Abdhesh
authors.initials: A
authors.lastname: Kumar
authors.forename: Manavi
authors.initials: M
authors.lastname: Chatterjee
authors.forename: K Bhaskara
authors.initials: KB
authors.lastname: Rao
authors.forename: Seema
authors.initials: S
authors.lastname: Singh
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Verma
authors.forename: Gautam
authors.initials: G
authors.lastname: Palit
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D008297:Male; D051379:Mice; D013055:Spectrophotometry, Infrared; D013312:Stress, Physiological; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D003374:Coumarins