title: Effect of cellulose, pectin and chromium(III) on lipid and carbohydrate metabolism in rats.
abstract: The effects of cellulose, pectin and chromium(III) on lipid and carbohydrate metabolism were investigated in rats. Eighty male Buffalo rats (n=10/group, 4 weeks old) were fed experimental diets for 6 weeks. The two control groups received a fiber free diet (FF) or a fiber free diet plus chromium (FF+Cr) (2.53 mg Cr/kg diet). The other groups were fed diets containing 5% of cellulose (CEL), 5% of pectin (PEC) or 2.5% of cellulose plus 2.5% of pectin (CEL+PEC) with or without chromium. The daily food intake and body weight of the rats were not affected by the experimental diets. Total cholesterol level in plasma was significantly lower (p≤0.05) in the PEC group than the rats fed the FF diet. Feeding of rats with the PEC+Cr diet resulted in a significantly higher concentration of plasma HDL cholesterol (p≤0.05) when compared with the CEL+Cr group. No statistically significant differences in the concentrations of plasma triglycerides (TG) and non-esterified fatty acids (NEFA) between the groups were observed. Rats fed the CEL+Cr diet had a significantly lower content of cholesterol and rats fed the CEL+Cr diet lower contents of cholesterol and TG in the liver (p≤0.05) when compared with other groups. The concentration of HbA1c was significantly lower (p≤0.05) in rats fed the CEL and CEL+Cr diets than in other groups. A significantly lower concentration of plasma glucose (p≤0.05) was observed in rats receiving the CEL+PEC diet in comparison with the FF group. A significant effect of fiber and chromium combination was shown only in the case of triglyceride content in the liver of rats (p≤0.05). In conclusion, our results suggest that a diet containing fiber (PEC) and chromium or their supplements may be beneficial for correcting some disturbances of lipid metabolism, and a diet containing cellulose or its supplements may be used to improve glycemic control.
authors.affiliation: Department of Food Science and Dietetics, Silesian Piasts University of Medicine, Wroclaw, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Krzysik
authors.forename: Halina
authors.initials: H
authors.lastname: Grajeta
authors.forename: Anna
authors.initials: A
authors.lastname: Prescha
authors.forename: Ryszard
authors.initials: R
authors.lastname: Weber
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D002482:Cellulose / Q000008:administration & dosage / Q000494:pharmacology*; D002857:Chromium / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet; D019587:Dietary Supplements; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D010368:Pectins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011915:Rats, Inbred BUF
chemical_list: D002857:Chromium; D010368:Pectins; D002482:Cellulose