title: Glioma models: new GEMMs add "class" with genomic and expression correlations.
abstract: Malignant gliomas are characterized by accumulated aberrations affecting TP53, PTEN, and RB1 signaling. In this issue, Chow et al. discover that combinatorial loss of these tumor suppressors in mice induces gliomas with unexpected degrees of similarity to human pathologic, genomic, and expression subclasses recently revealed by large-scale genomic studies.
authors.affiliation: Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. keith_ligon@dfci.harvard.edu
authors.forename: Cécile L
authors.initials: CL
authors.lastname: Maire
authors.forename: Keith L
authors.initials: KL
authors.lastname: Ligon
mesh_terms: D000818:Animals; D001254:Astrocytoma / Q000235:genetics* / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics*; D055028:Comparative Genomic Hybridization; D020869:Gene Expression Profiling; D023281:Genomics / Q000379:methods; D005909:Glioblastoma / Q000235:genetics / Q000473:pathology; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008957:Models, Genetic; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D016160:Retinoblastoma Protein / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53; D051059:PTEN Phosphohydrolase