title: Frequency of Helicobacter pylori in biopsy proven gastritis and its association with lymphoid follicle formation.
abstract: OBJECTIVE
  To determine the frequency of H. pylori infection in biopsy proven gastritis and its association with lymphoid follicle formation.
  
  
  METHODS
  This was a cross sectional study conducted at the Department of Histopathology, Dow Diagnostic Reference and Research Laboratory between January 2008 and December 2009. Analysis of 185 gastric antral biopsy specimens was done. Tissue sections were stained with haematoxylin and eosin for histological examination for severity of gastritis and lymphoid follicle formation. Giemsa stain was used for H. pylori assessment.
  
  
  RESULTS
  Out of 185 cases, H pylori was found in 114 (61.6%) patients. Frequency of H. pylori infection was seen in fourth and fifth decades as 17.8% and 15.1% respectively. A total of 51 (27.6%) cases in which lymphoid follicle formation was found, 44 (38.6%) were associated with H. pylori infection. This association was statistically significant (p value < 0.0005) by using Chi square test.
  
  
  CONCLUSIONS
  The frequency of H. pylori infection is common in our population, moreover, significant association is seen between lymphoid follicle formation and H. pylori infection.
authors.affiliation: Department of Pathology, DIMC, Karachi.
authors.forename: Shiza Tariq
authors.initials: ST
authors.lastname: Siddiqui
authors.forename: Erum
authors.initials: E
authors.lastname: Naz
authors.forename: Farheen
authors.initials: F
authors.lastname: Danish
authors.forename: Talat
authors.initials: T
authors.lastname: Mirza
authors.forename: Sina
authors.initials: S
authors.lastname: Aziz
authors.forename: Adnan
authors.initials: A
authors.lastname: Ali
mesh_terms: D000328:Adult; D001399:Azure Stains; D001706:Biopsy; D003430:Cross-Sectional Studies; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology* / Q000473:pathology; D005756:Gastritis / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D001399:Azure Stains