title: Endocavitary in vivo dosimetry for IMRT treatments of gynecologic tumors.
abstract: The accuracy and reproducibility of endometrial carcinoma treatment with intensity-modulated radiotherapy (IMRT) was assessed by means of in vivo dosimetry. Six patients who had previously undergone radical hysterectomy for endometrial carcinoma were treated with IMRT using a vaginal applicator with radio-opaque fiducial markers. An ion-chamber inserted into the applicator supplied an endocavitary in vivo dosimetry for quality assurance purposes. The ratio R = D/D(TPS) between the in vivo measured dose D and the predicted dose by the treatment planning system D(TPS) was determined for every fraction of the treatment. Results showed that 90% and 100% of the ratios resulted equal to 1 within 5% and 10%, respectively. The mean value of the ratios distribution for the 6 patients was R = 0.995 and the SD = 0.034. The ratio R* between the measured and predicted total doses for each patient was near to 1, within 2%. The dosimetric results suggest that the use of a vaginal applicator in an image-guided approach could make the interfractions target position stable and reproducible, allowing a safe use of the IMRT technique in the treatment of postoperative vaginal vault. In vivo dosimetry may supply useful information about the discrimination of random vs. systematic errors. The workload is minimum and this in vivo dosimetry can be applied also in the clinical routine.
authors.affiliation: Medical Physics Unit, John Paul II Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy. savinocilla@gmail.com
authors.forename: Savino
authors.initials: S
authors.lastname: Cilla
authors.forename: Gabriella
authors.initials: G
authors.lastname: Macchia
authors.forename: Cinzia
authors.initials: C
authors.lastname: Digesù
authors.forename: Francesco
authors.initials: F
authors.lastname: Deodato
authors.forename: Domenico
authors.initials: D
authors.lastname: Sabatino
authors.forename: Alessio G
authors.initials: AG
authors.lastname: Morganti
authors.forename: Angelo
authors.initials: A
authors.lastname: Piermattei
mesh_terms: D002138:Calibration; D019583:Dose Fractionation, Radiation; D016889:Endometrial Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D057918:Fiducial Markers; D006801:Humans; D007044:Hysterectomy; D056888:Patient Positioning; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed