title: Diffuse idiopathic skeletal hyperostosis and its relation to back pain among older men: the MrOS Study.
abstract: OBJECTIVE
  To estimate the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in a cross-sectional study of elderly men age 65 to 100 years and to examine back and neck pain as possible correlates of DISH.
  
  
  METHODS
  DISH was defined using Resnick's criteria and scored according to Mata on lateral spine radiographs of 298 randomly selected participants from the MrOS Study. Standardized self-reported questionnaires were used to assess the frequency and severity of back and neck pain, and the relation of these to DISH status was estimated with χ(2) tests, as well as prevalence ratios and 95% confidence intervals using log-binomial regression models.
  
  
  RESULTS
  DISH was observed in 126 older men (42%), increased with age (30%, 39%, 48%, and 56% for ages 65-69, 70-74, 75-79, and ≥80 respectively), and was positively associated with body mass index (BMI) (P = 0.04) and blood pressure (P = 0.02). Significantly less back pain in the past 12 months was reported among men with DISH as compared to men without (59% vs 71%, P = 0.03), which remained after adjustment for age, BMI, and blood pressure (prevalence ratios = 0.73, 95% confidence interval = 0.57-0.95). Back pain severity (P = 0.07) and frequency (P = 0.06) were also less frequent among men with DISH compared to men without, whereas reported neck pain was similar between groups (P = 0.39).
  
  
  CONCLUSIONS
  Among community-dwelling elderly men, DISH prevalence is high, increases with age, and is positively associated with BMI and blood pressure. Frequency of self-reported back pain over the past 12 months was lower in older men with DISH as compared to those without DISH.
authors.affiliation: Department of Orthopaedics and Rehabilitation, Oregon Health and Science University, Portland, OR 97239-3098, USA. holtonk@ohsu.edu
authors.forename: Kathleen F
authors.initials: KF
authors.lastname: Holton
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Denard
authors.forename: Jung U
authors.initials: JU
authors.lastname: Yoo
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Kado
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Barrett-Connor
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Marshall
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001416:Back Pain / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D001794:Blood Pressure; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D006801:Humans; D004057:Hyperostosis, Diffuse Idiopathic Skeletal / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology*; D008297:Male; D019547:Neck Pain / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D011859:Radiography; D014481:United States / Q000453:epidemiology