title: Preparation and characterization of biodegradable and electroactive polymer blend materials based on mPEG/tetraaniline and PLLA.
abstract: A novel PGTA diblock copolymer containing electroactive TEA and mPEG is described. Biodegradable PLLA/PGTA polymer blends are shown to be electroactive. Nanopores of different sizes can be formed on the surface of the polymer blends. An MTT assay shows that the PLLA/PGTA blends exhibited reduced cytotoxicity as compared to TEA due to the introduction of the biocompatible PLLA moiety. Cell culture results show that the cells grow better when they were adhered to the surface of the PLLA/PGTA blends. The 80/20 wt.-% PLLA/PGTA blend shows the best biocompatibility and an electroactivity that accelerates the differentiation of rat C6 glioma cells.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhuang
authors.forename: Peibiao
authors.initials: P
authors.lastname: Zhang
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
authors.forename: Yen
authors.initials: Y
authors.lastname: Wei
authors.forename: Xianhong
authors.initials: X
authors.lastname: Wang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000378:metabolism; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004553:Electric Conductivity; D005910:Glioma / Q000473:pathology; D018625:Microscopy, Atomic Force; D058608:Nanopores / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry* / Q000378:metabolism; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000378:metabolism; D051381:Rats; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D001672:Biocompatible Materials; D011091:Polyesters; D011092:Polyethylene Glycols; C033616:poly(lactide); C028210:monomethoxypolyethylene glycol; C023650:aniline