title: Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice.
abstract: Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect.
authors.affiliation: Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina.
authors.forename: Evelin M
authors.initials: EM
authors.lastname: Elia
authors.forename: Carolina
authors.initials: C
authors.lastname: Pustovrh
authors.forename: Sabrina
authors.initials: S
authors.lastname: Amalfi
authors.forename: Luigi
authors.initials: L
authors.lastname: Devoto
authors.forename: Alicia Beatriz
authors.initials: AB
authors.lastname: Motta
mesh_terms: D000818:Animals; D001092:Arachidonate 12-Lipoxygenase / Q000378:metabolism; D001093:Arachidonate 15-Lipoxygenase / Q000378:metabolism; D003687:Dehydroepiandrosterone; D004195:Disease Models, Animal; D015536:Down-Regulation; D005260:Female; D017588:Hyperandrogenism / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008024:Ligands; D008687:Metformin / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D047495:PPAR gamma / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D046468:Sexual Development; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D007004:Hypoglycemic Agents; D008024:Ligands; D047495:PPAR gamma; D012333:RNA, Messenger; D003687:Dehydroepiandrosterone; D008687:Metformin; D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase