title: [Carcinoma of the anal canal: state of art, issues in geriatric oncology and molecular targeted therapies].
abstract: Since the 1990, chemoradiation has become the standard treatment for locally advanced anal cancer. Recent progress in molecular biology and the growing number of elderly patients invite the clinicians to personalize the multimodal therapy strategy. However, data about anal cancer and elderly patients or targeted therapy are extremely sparse. Indeed, national or international guidelines don't mention these two subjects. The purpose of this article is to make the state of art of the management of anal cancer and its interferences with geriatrics and molecular targeted therapy.
authors.affiliation: Institut de cancérologie de la Loire, département de radiothérapie, Saint-Priest-en-Jarez, France.
authors.forename: Ngoc-Hanh
authors.initials: NH
authors.lastname: Hau Desbat
authors.forename: Pierre
authors.initials: P
authors.lastname: Auberdiac
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chargari
authors.forename: Yacine
authors.initials: Y
authors.lastname: Merrouche
authors.forename: Eric
authors.initials: E
authors.lastname: Deutsch
authors.forename: Thierry
authors.initials: T
authors.lastname: Schmitt
authors.forename: Guy
authors.initials: G
authors.lastname: de Laroche
authors.forename: Nicolas
authors.initials: N
authors.lastname: Magné
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001005:Anus Neoplasms / Q000473:pathology / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D009367:Neoplasm Staging / Q000379:methods; D017410:Practice Guidelines as Topic; D011878:Radiotherapy / Q000379:methods