title: The roles of ascorbic acid and glutathione in symptom alleviation to SA-deficient plants infected with RNA viruses.
abstract: Salicylic acid (SA) is required for plant systemic acquired resistance (SAR) to viruses. However, SA-deficient plants adapt to RNA virus infections better, which show a lighter symptom and have less reactive oxygen species (ROS) accumulation. The virus replication levels are higher in the SA-deficient plants during the first 10 days, but lower than the wild-type seedlings after 20 dpi. The higher level of glutathione and ascorbic acid (AsA) in SA-deficient plants may contribute to their alleviated symptoms. Solo virus-control method for mortal viruses results in necrosis and chlorosis, no matter what level of virus RNAs would accumulate. Contrastingly, early and high-dose AsA treatment alleviates the symptom, and eventually inhibits virus replication after 20 days. ROS eliminators could not imitate the effect of AsA, and could neither alleviate symptom nor inhibit virus replication. It suggests that both symptom alleviation and virus replication control should be considered for plant virus cures.
authors.affiliation: Plant Pathology Laboratory, College of Life Science, Sichuan University, Chengdu 610064, China.
authors.forename: Shao-Dong
authors.initials: SD
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Shu
authors.initials: S
authors.lastname: Yuan
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Fei
authors.initials: F
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Shang
authors.forename: Mo-Yun
authors.initials: MY
authors.lastname: Xu
authors.forename: Shu-Dan
authors.initials: SD
authors.lastname: Jia
authors.forename: Zhong-Wei
authors.initials: ZW
authors.lastname: Zhang
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Wang
authors.forename: De-Hui
authors.initials: DH
authors.lastname: Xi
authors.forename: Hong-Hui
authors.initials: HH
authors.lastname: Lin
mesh_terms: D017360:Arabidopsis / Q000821:virology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D005978:Glutathione / Q000494:pharmacology*; D007113:Immunity, Innate; D010935:Plant Diseases / Q000628:therapy / Q000821:virology*; D010942:Plant Viruses / Q000502:physiology*; D012328:RNA Viruses / Q000502:physiology*; D020156:Salicylic Acid / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D005978:Glutathione; D020156:Salicylic Acid; D001205:Ascorbic Acid