title: Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides.
abstract: A series of novel isatine-sulphonamide derivatives have been synthesized by combining isatin derivatives with sulphonamides. The structure of the synthesized compounds were elucidated by spectral analysis (IR, NMR and Mass). Investigation of anti-HIV activity was done against HIV-1(IIIB) in MT-4 cells and HIV integrase inhibitory activity. 4-(1-acetyl-5-methyl-2-oxoindolin-3-ylideneamino)-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (SPIII-5ME-AC) inhibits the HIV Integrase enzymatic activity as both over all and strand transfer reaction and 4-(1-benzoyl-5-chloro-2-oxoindolin-3-ylideneamino)-N-(4,6-dimethylpyrimidin-2-yl)benzene sulfonamide (SPIII-5Cl-BZ) exhibits 36 percent maximum protection against HIV-1 at sub toxic concentration.
authors.affiliation: Arulmigu Kalasalingam College of Pharmacy, Anand nagar, Krishnankoil-626 190, India.
authors.forename: P
authors.initials: P
authors.lastname: Selvam
authors.forename: N
authors.initials: N
authors.lastname: Murugesh
authors.forename: M
authors.initials: M
authors.lastname: Chandramohan
authors.forename: Z
authors.initials: Z
authors.lastname: Debyser
authors.forename: M
authors.initials: M
authors.lastname: Witvrouw