title: MONW phenotype is associated with advanced colorectal adenoma in Korean men.
abstract: The aim of this study was to investigate whether there was a relationship between colorectal adenoma and metabolically obese but normal weight (MONW) among Korean men and women. The MONW phenotype is defined as a BMI <25, but fulfilling the metabolic syndrome (MS) criteria with a modified waist circumference (≥90 cm for men and ≥85 cm for women) appropriate for Korean. A total of 3,430 subjects (2,263 men and 1,167 women; 23-75 years old) were included in the study. Colorectal adenomas were diagnosed in 775 men and 199 women. The rate of advanced adenomas in males was 24.3% and in females 21.1%. A significant association between MONW and advanced colorectal adenoma was found in men (age-adjusted odds ratio (OR) = 1.92, 95% confidence interval (CI): 1.06-3.47) but not in women (age-adjusted OR = 1.80, 95% CI: 0.50-6.45). The findings suggest that men with MONW may have an increased risk of developing advanced colorectal adenoma whereas this does not seem true for females.
authors.affiliation: Department of Family Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
authors.forename: Moon-Chan
authors.initials: MC
authors.lastname: Kim
authors.forename: Chang-Sup
authors.initials: CS
authors.lastname: Kim
authors.forename: Tae-Heum
authors.initials: TH
authors.lastname: Chung
authors.forename: Joseph
authors.initials: J
authors.lastname: Jeong
authors.forename: Seon-Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Sung-Ryul
authors.initials: SR
authors.lastname: Kim
authors.forename: Seok-Won
authors.initials: SW
authors.lastname: Jung
authors.forename: Neung-Hwa
authors.initials: NH
authors.lastname: Park
authors.forename: Cheol-In
authors.initials: CI
authors.lastname: Yoo
mesh_terms: D000236:Adenoma / Q000453:epidemiology* / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data*; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D056910:Republic of Korea / Q000453:epidemiology; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology / Q000235:genetics; D055105:Waist Circumference / Q000235:genetics; D055815:Young Adult