title: Cerebral venous thrombosis in a Mexican multicenter registry of acute cerebrovascular disease: the RENAMEVASC study.
abstract: BACKGROUND
  Cerebral venous thrombosis (CVT) is a rare form of cerebrovascular disease that is usually not mentioned in multicenter registries on all-type acute stroke. We aimed to describe the experience on hospitalized patients with CVT in a Mexican multicenter registry on acute cerebrovascular disease.
  
  
  METHODS
  CVT patients were selected from the RENAMEVASC registry, which was conducted between 2002 and 2004 in 25 Mexican hospitals. Risk factors, neuroimaging, and 30-day outcome as assessed by the modified Rankin scale (mRS) were analyzed.
  
  
  RESULTS
  Among 2000 all-type acute stroke patients, 59 (3%; 95% CI, 2.3-3.8%) had CVT (50 women; female:male ratio, 5:1; median age, 31 years). Puerperium (42%), contraceptive use (18%), and pregnancy (12%) were the main risk factors in women. In 67% of men, CVT was registered as idiopathic, but thrombophilia assessment was suboptimal. Longitudinal superior sinus was the most frequent thrombosis location (78%). Extensive (>5 cm) venous infarction occurred in 36% of patients. Only 81% of patients received anticoagulation since the acute phase, and 3% needed decompressive craniectomy. Mechanical ventilation (13.6%), pneumonia (10.2%) and systemic thromboembolism (8.5%) were the main in-hospital complications. The 30-day case fatality rate was 3% (2 patients; 95% CI, 0.23-12.2%). In a Cox proportional hazards model, only age <40 years was associated with a mRS score of 0 to 2 (functional independence; rate ratio, 3.46; 95% CI, 1.34-8.92).
  
  
  CONCLUSIONS
  The relative frequency of CVT and the associated in-hospital complications were higher than in other registries. Thrombophilia assessment and acute treatment was suboptimal. Young age is the main determinant of a good short-term outcome.
authors.affiliation: Department of Neurology, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico. jorulej-1nj@prodigy.net.mx
authors.forename: José L
authors.initials: JL
authors.lastname: Ruiz-Sandoval
authors.forename: Erwin
authors.initials: E
authors.lastname: Chiquete
authors.forename: L Jacqueline
authors.initials: LJ
authors.lastname: Bañuelos-Becerra
authors.forename: Carolina
authors.initials: C
authors.lastname: Torres-Anguiano
authors.forename: Christian
authors.initials: C
authors.lastname: González-Padilla
authors.forename: Antonio
authors.initials: A
authors.lastname: Arauz
authors.forename: Carolina
authors.initials: C
authors.lastname: León-Jiménez
authors.forename: Luis M
authors.initials: LM
authors.lastname: Murillo-Bonilla
authors.forename: Jorge
authors.initials: J
authors.lastname: Villarreal-Careaga
authors.forename: Fernando
authors.initials: F
authors.lastname: Barinagarrementería
authors.forename: Carlos
authors.initials: C
authors.lastname: Cantú-Brito
mesh_terms: D000328:Adult; D000367:Age Factors; D002550:Cerebral Veins; D002561:Cerebrovascular Disorders; D005260:Female; D006760:Hospitalization; D006801:Humans; D053208:Kaplan-Meier Estimate; D007902:Length of Stay; D008297:Male; D008800:Mexico / Q000453:epidemiology; D059906:Neuroimaging; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000150:complications*; D020246:Venous Thrombosis / Q000150:complications* / Q000453:epidemiology; D055815:Young Adult