title: Green tea may be benefit to the therapy of atrial fibrillation.
abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice. Systemic inflammatory state, oxidative stress injury, and atrial fibrosis are identified as the main mechanisms for AF. Considering the multifactorial mechanisms of AF, a novel therapeutic agent with multi-bioactivities should be presented. Regular consumption of green tea has been associated with a reduced risk of coronary heart disease and against a large number of pathologic conditions. Recent results indicate that green tea extract, especially (-)-epigallocatechin-3-gallate, could effectively decrease inflammatory factors secretion, antagonize oxidation, and inhibit matrix metalloproteinase activities. Inhibition of inflammation, modulation of oxidative stress, and targeting tissue fibrosis represent new approaches in tackling AF; therefore, green tea may be an innovative therapeutic candidate to prevent the occurrence, maintenance, and recurrence of AF.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Peoples' Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zeng
authors.forename: Qiao
authors.initials: Q
authors.lastname: Li
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xuerui
authors.initials: X
authors.lastname: Tan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D005355:Fibrosis; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control; D009206:Myocardium / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D013662:Tea
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate