title: [Combination chemotherapy of S-1/low-dose CDDP/lentinan for advanced gastric cancer].
abstract: Eight patients with inoperable advanced gastric cancer were treated with combination chemotherapy of S-1, low-dose cisplatin(CDDP)and Lentinan. S-1 80 mg/ m² was orally administered for 2 weeks followed by 1-week rest, CDDP 15 mg/ m² and Lentinan 2 mg/body were given intravenously on day 1 and 8. One complete response and four partial responses were observed for an overall response rate of 63%(5 of 8 patients). Only one patient developed over grade 3 toxicity leukocytopenia. Many patients could be maintained by long-term continuous treatment. Since combination chemotherapy of S-1/low-dose CDDP/Lentinan for advanced gastric cancer was very tolerable, it could be used for a long time.
authors.affiliation: Dept. of Surgery, Kashiwara Municipal Hospital, Osaka City General Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hori
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Ikehara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takatsuka
authors.forename: Tatsunari
authors.initials: T
authors.lastname: Fukuoka
authors.forename: Masanari
authors.initials: M
authors.lastname: Tendo
authors.forename: Kenji
authors.initials: K
authors.lastname: Tezuka
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Dan
authors.forename: Hiroji
authors.initials: H
authors.lastname: Nishino
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007912:Lentinan / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D007912:Lentinan; D010094:Oxonic Acid; D002945:Cisplatin