title: Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia.
abstract: We have identified two novel ABL1 fusion genes in two patients with B-cell acute lymphoblastic leukaemia (ALL) associated with a t(3;9)(p12;q34) and a t(5;9)(q23;q34), respectively. Molecular analysis revealed a FOXP1-ABL1 fusion for the t(3;9) and a SNX2-ABL1 fusion for the t(5;9). The fusions were confirmed by specific amplification of the genomic breakpoints using reverse transcription polymerase chain reaction. The identification of ALL with rare ABL1 fusion partners is important because the leukaemia may respond to tyrosine kinase inhibitors in the same way as ALL patients with a classical BCR-ABL1 fusion gene.
authors.affiliation: University of Southampton School of Medicine, Southampton, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ernst
authors.forename: Joannah
authors.initials: J
authors.lastname: Score
authors.forename: Michael
authors.initials: M
authors.lastname: Deininger
authors.forename: Claire
authors.initials: C
authors.lastname: Hidalgo-Curtis
authors.forename: Peter
authors.initials: P
authors.lastname: Lackie
authors.forename: William B
authors.initials: WB
authors.lastname: Ershler
authors.forename: John M
authors.initials: JM
authors.lastname: Goldman
authors.forename: Nicholas C P
authors.initials: NC
authors.lastname: Cross
authors.forename: Francish
authors.initials: F
authors.lastname: Grand
mesh_terms: D000293:Adolescent; D000328:Adult; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D006801:Humans; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D016315:Proto-Oncogene Proteins c-abl / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D058305:Sorting Nexins / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D015514:Oncogene Proteins, Fusion; D012097:Repressor Proteins; C513979:SNX2 protein, human; D058305:Sorting Nexins; D016315:Proto-Oncogene Proteins c-abl