title: Wasabi nose: an underreported complication of cyclophosphamide infusions.
abstract: Wasabi nose, a term used to describe the nasopharyngeal discomfort experienced during cyclophosphamide infusions, is a rare phenomenon, previously described in case reports of adult oncology patients typically receiving high-dose chemotherapy regimens. The underlying mechanism by which this phenomenon occurs is unknown. We report four cases of children with rheumatic diseases afflicted by profound nasopharyngeal discomfort secondary to low-dose cyclophosphamide infusions. We additionally review the literature regarding potential medical management of these complications and describe our experience using these interventions.
authors.affiliation: Department of Pediatrics, Division of Rheumatology, Children's Hospital at Montefiore, 3415 Bainbridge Avenue, Bronx, New York, NY 10463, USA.
authors.forename: Ginger L
authors.initials: GL
authors.lastname: Janow
authors.forename: Norman T
authors.initials: NT
authors.lastname: Ilowite
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Wahezi
mesh_terms: D000293:Adolescent; D003520:Cyclophosphamide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007262:Infusions, Intravenous; D009302:Nasopharyngeal Diseases / Q000139:chemically induced* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide