title: Pathogenesis of Mycosis fungoides.
abstract: Mycosis fungoides is the most common type of primary cutaneous lymphomas. The phenotype of the tumor cell corresponds to an effector/memory-type of helper T cell which, given its repertoire of homing receptors, is specialized for recirculation through the skin. In recent years genetic analyses have uncovered various chromosomal aberrations in the tumour cells of mycosis fungoides. Their relevance to the pathogenesis and clinical appearance are discussed in the following.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Charité- Universitätsmedizin Berlin, Germany. marc.beyer@charite.de
authors.forename: Marc
authors.initials: M
authors.lastname: Beyer
authors.forename: Markus
authors.initials: M
authors.lastname: Möbs
authors.forename: Daniel
authors.initials: D
authors.lastname: Humme
authors.forename: Wolfram
authors.initials: W
authors.lastname: Sterry
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000276:immunology / Q000473:pathology; D018925:Chemokines / Q000097:blood; D002869:Chromosome Aberrations; D016207:Cytokines / Q000097:blood; D000939:Epitopes / Q000276:immunology; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D009367:Neoplasm Staging; D010641:Phenotype; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D018925:Chemokines; D016207:Cytokines; D000939:Epitopes