title: Matrix control of scarring.
abstract: Repair of wounds usually results in restoration of organ function, even if suboptimal. However, in a minority of situations, the healing process leads to significant scarring that hampers homeostasis and leaves the tissue compromised. This scar is characterized by an excess of matrix deposition that remains poorly organized and weakened. While we know much of the early stages of the repair process, the transition to wound resolution that limits scar formation is poorly understood. This is particularly true of the inducers of scar formation. Here, we present a hypothesis that it is the matrix itself that is a primary driver of scar, rather than being simply the result of other cellular dysregulations.
authors.affiliation: Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: Cecelia C
authors.initials: CC
authors.lastname: Yates
authors.forename: Richard
authors.initials: R
authors.lastname: Bodnar
authors.forename: Alan
authors.initials: A
authors.lastname: Wells
mesh_terms: D002921:Cicatrix; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D054367:Receptors, CXCR3 / Q000378:metabolism; D014945:Wound Healing
chemical_list: C515187:CXCR3 protein, human; D054367:Receptors, CXCR3