title: New developments and opportunities in oral mucosal drug delivery for local and systemic disease.
abstract: The oral mucosa's accessibility, excellent blood supply, by-pass of hepatic first-pass metabolism, rapid repair and permeability profile make it an attractive site for local and systemic drug delivery. Technological advances in mucoadhesives, sustained drug release, permeability enhancers and drug delivery vectors are increasing the efficient delivery of drugs to treat oral and systemic diseases. When treating oral diseases, these advances result in enhanced therapeutic efficacy, reduced drug wastage and the prospect of using biological agents such as genes, peptides and antibodies. These technologies are also increasing the repertoire of drugs that can be delivered across the oral mucosa to treat systemic diseases. Trans-mucosal delivery is now a favoured route for non-parenteral administration of emergency drugs and agents where a rapid onset of action is required. Furthermore, advances in drug delivery technology are bringing forward the likelihood of transmucosal systemic delivery of biological agents.
authors.affiliation: Unit of Oral & Maxillofacial Medicine & Surgery, University of Sheffield School of Clinical Dentistry, Claremont Crescent, Sheffield, UK. vanessahearnden@gmail.com
authors.forename: Vanessa
authors.initials: V
authors.lastname: Hearnden
authors.forename: Vidya
authors.initials: V
authors.lastname: Sankar
authors.forename: Katrusha
authors.initials: K
authors.lastname: Hull
authors.forename: Danica Vidović
authors.initials: DV
authors.lastname: Juras
authors.forename: Martin
authors.initials: M
authors.lastname: Greenberg
authors.forename: A Ross
authors.initials: AR
authors.lastname: Kerr
authors.forename: Peter B
authors.initials: PB
authors.lastname: Lockhart
authors.forename: Lauren L
authors.initials: LL
authors.lastname: Patton
authors.forename: Stephen
authors.initials: S
authors.lastname: Porter
authors.forename: Martin H
authors.initials: MH
authors.lastname: Thornhill
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D006801:Humans; D009061:Mouth Mucosa / Q000378:metabolism*; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
chemical_list: D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations