title: Cycloartane glycosides from Astragalus aureus.
abstract: Eight cycloartane-type triterpene glycosides (1-8) were isolated from Astragalus aureus Willd along with ten known cycloartane-type glycosides (9-18). Their structures were established by the extensive use of 1D and 2D-NMR experiments along with ESIMS and HRMS analyses. Compounds 1-5 are cyclocanthogenin glycosides, whereas compounds 6-8 are based on cyclocephalogenin as aglycon, more unusual in the plant kingdom, so far reported only from Astragalus spp. Moreover, for the first time monoglycosides of cyclocanthogenin (5) and cyclocephalogenin (7, 8) are reported. All of the compounds tested for their cytotoxic activities against a number of cancer cell lines. Among the compounds, only 8 exhibited activity versus human breast cancer (MCF7) at 45 μM concentration.
authors.affiliation: Department of Chemistry, Faculty of Science, Ege University, Bornova-İzmir, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Gülcemal
authors.forename: Ozgen
authors.initials: O
authors.lastname: Alankuş-Çalışkan
authors.forename: Angela
authors.initials: A
authors.lastname: Perrone
authors.forename: Fevzi
authors.initials: F
authors.lastname: Ozgökçe
authors.forename: Sonia
authors.initials: S
authors.lastname: Piacente
authors.forename: Erdal
authors.initials: E
authors.lastname: Bedir
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027883:Astragalus Plant / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D008297:Male; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014421:Turkey
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D014315:Triterpenes; C085352:cycloartane