title: Mining microarray data to predict the histological grade of a breast cancer.
abstract: BACKGROUND
  The aim of this study was to develop an original method to extract sets of relevant molecular biomarkers (gene sequences) that can be used for class prediction and can be included as prognostic and predictive tools.
  
  
  METHODS
  The method is based on sequential patterns used as features for class prediction. We applied it to classify breast cancer tumors according to their histological grade.
  
  
  RESULTS
  We obtained very good recall and precision for grades 1 and 3 tumors, but, like other authors, our results were less satisfactory for grade 2 tumors.
  
  
  CONCLUSIONS
  We demonstrated the interest of sequential patterns for class prediction of microarrays and we now have the material to use them for prognostic and predictive applications.
authors.affiliation: LIRMM UM2 CNRS, UMR 5506 - CC 477, 161 rue Ada, 34095 Montpellier Cedex 5, France.
authors.forename: Mickael
authors.initials: M
authors.lastname: Fabregue
authors.affiliation: LIRMM UM2 CNRS, UMR 5506 - CC 477, 161 rue Ada, 34095 Montpellier Cedex 5, France; MIAp UM3, Université Paul-Valery, Route de Mende, 34199 Montpellier Cedex, France. Electronic address: bringay@lirmm.fr.
authors.forename: Sandra
authors.initials: S
authors.lastname: Bringay
authors.affiliation: LIRMM UM2 CNRS, UMR 5506 - CC 477, 161 rue Ada, 34095 Montpellier Cedex 5, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Poncelet
authors.affiliation: CEMAGREF, Maison de la télé-détection, 500 Rue Jean-François Breton, 34000 Montpellier, France.
authors.forename: Maguelonne
authors.initials: M
authors.lastname: Teisseire
authors.affiliation: IRCM Institut de Recherche en Cancérologie de Montpellier INSERM U896 - UM1 - CRLC Val d'Aurelle - Paul Lamarque, F-34298 Montpellier Cedex 5, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Orsetti
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D057225:Data Mining / Q000379:methods*; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D009367:Neoplasm Staging; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*