title: Pulmonary epithelioid hemangioendothelioma with PlGF expression: report of a case.
abstract: Pulmonary epithelioid hemangioendothelioma (PEH) is a relatively uncommon neoplasm of vascular origin with a low or intermediate grade of malignancy. We present a case of a 28-year-old female with multiple pulmonary nodules which were diagnosed as PEH by video-assisted thoracoscopic surgery (VATS) biopsy. In addition, we performed an immunohistochemical analysis for placenta growth factor (PlGF) and a strong positivity for PlGF observed, suggesting that the PlGF may play some role in the tumorigenesis of PEH.
authors.affiliation: General Thoracic Surgery, Tottori University Hospital, Yonago, Japan. tharuki@med.tottori-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Haruki
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Nosaka
authors.forename: K
authors.initials: K
authors.lastname: Shomori
authors.forename: H
authors.initials: H
authors.lastname: Ito
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000737:chemistry* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000601:surgery; D055613:Multiple Pulmonary Nodules / Q000737:chemistry* / Q000175:diagnosis / Q000601:surgery; D000072483:Placenta Growth Factor; D011013:Pneumonectomy; D011257:Pregnancy Proteins / Q000032:analysis*; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed
chemical_list: C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor