title: A domino process for benzyne preparation: dual activation of o-(trimethylsilyl)phenols by nonafluorobutanesulfonyl fluoride.
abstract: Benzynes were generated from o-(trimethylsilyl)phenols using nonafluorobutanesulfonyl fluoride (NfF) by a domino process, i.e., the nonaflation of the phenolic hydroxyl group of o-(trimethylsilyl)phenols by NfF followed by the attack of the produced fluoride ion on the trimethylsilyl group. The generated benzyne immediately underwent various reactions to give polysubstituted benzenes.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka, Shizuoka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ikawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nishiyama
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Nosaki
authors.forename: Akira
authors.initials: A
authors.lastname: Takagi
authors.forename: Shuji
authors.initials: S
authors.lastname: Akai
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D002073:Butanes / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives; D002073:Butanes; D010636:Phenols; D013450:Sulfones; C524146:benzyne; D005459:Fluorides