title: Label-free biosensing with lipid-functionalized gold nanorods.
abstract: The fabrication of a label-free mass spectrometry and optical detection-based biosensor platform for the detection of low-abundance lipophilic analytes in complex mixtures is described. The biosensor consists of a lipid layer partially tethered to the surface of a gold nanorod. The effectiveness of the biosensor is demonstrated for the label-free detection of a lipophilic drug in aqueous solution and a lipopeptide in serum.
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
authors.forename: Edward T
authors.initials: ET
authors.lastname: Castellana
authors.forename: Roberto C
authors.initials: RC
authors.lastname: Gamez
authors.forename: David H
authors.initials: DH
authors.lastname: Russell
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D002417:Cattle; D006046:Gold / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D013058:Mass Spectrometry; D043942:Nanotubes / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008055:Lipids; D006046:Gold