title: Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence.
abstract: Alcoholism is characterized by a progressive loss of control over ethanol intake. The purpose of this study was to identify transcriptional changes selectively associated with excessive ethanol drinking in dependent mice, as opposed to non-dependent mice maintaining a stable voluntary consumption or mice solely undergoing forced intoxication. We measured expression levels of 106 candidate genes in the extended amygdala, a key brain structure for the development of drug addiction. Cluster analysis identified 17 and 15 genes selectively induced or repressed, respectively, under conditions of excessive drinking. These genes belong to signaling pathways involved in neurotransmission and transcriptional regulation.
authors.affiliation: The Scripps Research Institute, Committee on the Neurobiology of Addictive Disorders, La Jolla, CA 92037, USA. contet@scripps.edu
authors.forename: Candice
authors.initials: C
authors.lastname: Contet
authors.forename: Olivier
authors.initials: O
authors.lastname: Gardon
authors.forename: Dominique
authors.initials: D
authors.lastname: Filliol
authors.forename: Jérôme A J
authors.initials: JA
authors.lastname: Becker
authors.forename: George F
authors.initials: GF
authors.lastname: Koob
authors.forename: Brigitte L
authors.initials: BL
authors.lastname: Kieffer
mesh_terms: D000435:Alcoholic Intoxication / Q000235:genetics* / Q000503:physiopathology*; D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology*; D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D056726:Genetic Association Studies; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017450:Receptors, Opioid, mu / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D009435:Synaptic Transmission / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D017450:Receptors, Opioid, mu