title: Probability of Detection (POD) as a statistical model for the validation of qualitative methods.
abstract: A statistical model is presented for use in validation of qualitative methods. This model, termed Probability of Detection (POD), harmonizes the statistical concepts and parameters between quantitative and qualitative method validation. POD characterizes method response with respect to concentration as a continuous variable. The POD model provides a tool for graphical representation of response curves for qualitative methods. In addition, the model allows comparisons between candidate and reference methods, and provides calculations of repeatability, reproducibility, and laboratory effects from collaborative study data. Single laboratory study and collaborative study examples are given.
authors.affiliation: General Mills, Inc., 330 University Ave SE, Minneapolis, MN 55414, USA. paul.wehling@genmills.com
authors.forename: Paul
authors.initials: P
authors.lastname: Wehling
authors.forename: Robert A
authors.initials: RA
authors.lastname: LaBudde
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Brunelle
authors.forename: Maria T
authors.initials: MT
authors.lastname: Nelson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001628:Beverages / Q000382:microbiology; D002417:Cattle; D016001:Confidence Intervals; D019453:Escherichia coli O157 / Q000302:isolation & purification; D005516:Food Microbiology / Q000706:statistics & numerical data; D008460:Meat / Q000382:microbiology; D008828:Microbiological Techniques / Q000592:standards / Q000706:statistics & numerical data*; D015233:Models, Statistical; D011336:Probability; D012475:Salmonella / Q000302:isolation & purification