title: Uric acid and pentraxin-3 levels are independently associated with coronary artery disease risk in patients with stage 2 and 3 kidney disease.
abstract: OBJECTIVE
  Cardiovascular disease is prevalent in chronic kidney disease (CKD). Uric acid is increased in subjects with CKD and has been linked with cardiovascular mortality in this population. However, no study has evaluated the relationship of uric acid with angiographically proven coronary artery disease (CAD) in this population. We therefore investigated the link between serum uric acid (SUA) levels and (i) extent of CAD assessed by the Gensini score and (ii) inflammatory parameters, including C-reactive protein (CRP) and pentraxin-3, in patients with mild-to-moderate CKD.
  
  
  METHODS
  In an unselected population of 130 patients with estimated glomerular filtration rate (eGFR) between 90 and 30 ml/min/1.73 m(2), we measured SUA, serum pentraxin-3, CRP, urinary protein-to-creatinine ratio, lipid parameters and the severity of CAD as assessed by coronary angiography and quantified by the Gensini lesion severity score.
  
  
  RESULTS
  The mean serum values for SUA, pentraxin-3 and CRP in the entire study population were 5.5 ± 1.5 mg/dl, 6.4 ± 3.4 ng/ml and 3.5 ± 2.6 mg/dl, respectively. The Gensini scores significantly correlated in univariate analysis with gender (R = -0.379, p = 0.02), uric acid (R = 0.42, p = 0.001), pentraxin-3 (R = 0.54, p = 0.001), CRP (R = 0.29, p = 0.006) levels, eGFR (R = -0.33, p = 0.02), proteinuria (R = 0.21, p = 0.01), and presence of hypertension (R = 0.37, p = 0.001), but not with smoking status, diabetes mellitus, and lipid parameters. After adjustments for traditional cardiovascular risk factors, only uric acid (R = 0.21, p = 0.02) and pentraxin-3 (R = 0.28, p = 0.01) remained significant predictors of the Gensini score.
  
  
  CONCLUSIONS
  SUA and pentraxin-3 levels are independent determinants of severity of CAD in patients with mild-to-moderate CKD. We recommend a clinical trial to determine whether lowering uric acid could prevent progression of CAD in patients with CKD.
authors.affiliation: Division of Nephrology, Department of Medicine, Fatih University School of Medicine, Ankara, Turkey. drkanbay@yahoo.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ikizek
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Solak
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Selcoki
authors.forename: Sema
authors.initials: S
authors.lastname: Uysal
authors.forename: Ferah
authors.initials: F
authors.lastname: Armutcu
authors.forename: Beyhan
authors.initials: B
authors.lastname: Eryonucu
authors.forename: Adrian
authors.initials: A
authors.lastname: Covic
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Johnson
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000096:biosynthesis* / Q000378:metabolism; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications*; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007249:Inflammation; D007674:Kidney Diseases / Q000097:blood* / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D000683:Serum Amyloid P-Component / Q000096:biosynthesis*; D014527:Uric Acid / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D014527:Uric Acid; D000099153:Pentraxins