title: Bioactive sesqui- and diterpenoids from the Argentine liverwort Porella chilensis.
abstract: Four fusicoccane-type diterpenoids (1-4), including the new 1 and 2; four pinguisane-type sesquiterpenoids (5-8); and two aromadendrane-type sesquiterpenoids (9 and 10) were isolated from an Argentine collection of the endemic liverwort Porella chilensis. The biofilm formation of the human pathogen Pseudomonas aeruginosa was inhibited by compounds 3 (53 and 47%), 9 (45 and 41%), and 10 (48 and 37%) at 50 and 5 μg/mL, respectively. Compounds 3, 9, and 10 also produced a slight decrease in bacterial growth and interfere with the process of quorum sensing at the same doses.
authors.affiliation: INQUINOA-CONICET, Ayacucho 491, Tucumán 4000, Argentina.
authors.forename: Miguel
authors.initials: M
authors.lastname: Gilabert
authors.forename: Alberto N
authors.initials: AN
authors.lastname: Ramos
authors.forename: María M
authors.initials: MM
authors.lastname: Schiavone
authors.forename: Mario E
authors.initials: ME
authors.lastname: Arena
authors.forename: Alicia
authors.initials: A
authors.lastname: Bardón
mesh_terms: D001118:Argentina; D018441:Biofilms / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D053038:Quorum Sensing; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045789:Sesquiterpenes, Guaiane
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C519959:aromadendrane