title: Impact of IL-18 on inflammation.
abstract: IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis since the T cells and macrophages that invade the synovial. These finding support a role for IL-18 in inflammation, allergy and immune diseases.
authors.forename: D
authors.initials: D
authors.lastname: Tripodi
authors.forename: G
authors.initials: G
authors.lastname: Maccauro
authors.forename: A
authors.initials: A
authors.lastname: Anogeianaki
authors.forename: M L
authors.initials: ML
authors.lastname: Castellani
authors.forename: F
authors.initials: F
authors.lastname: Pandolfi
authors.forename: P
authors.initials: P
authors.lastname: Felaco
authors.forename: E
authors.initials: E
authors.lastname: Toniato
authors.forename: M A
authors.initials: MA
authors.lastname: De Lutiis
authors.forename: M
authors.initials: M
authors.lastname: Fulcheri
authors.forename: S
authors.initials: S
authors.lastname: Tetè
authors.forename: R
authors.initials: R
authors.lastname: Galzio
authors.forename: V
authors.initials: V
authors.lastname: Salini
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.forename: I
authors.initials: I
authors.lastname: Frydas
authors.forename: G
authors.initials: G
authors.lastname: Sabatino
authors.forename: Y B
authors.initials: YB
authors.lastname: Shaik-Dasthagirisaheb
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D020382:Interleukin-18 / Q000276:immunology*; D015603:Keratinocytes / Q000276:immunology; D007728:Kupffer Cells / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology
chemical_list: D020382:Interleukin-18; D008070:Lipopolysaccharides