title: Abnormal resting state corticolimbic blood flow in depressed unmedicated patients with major depression: a (15)O-H(2)O PET study.
abstract: We investigated the differences in the resting state corticolimbic blood flow between 20 unmedicated depressed patients and 21 healthy comparisons. Resting state cerebral blood flow (CBF) was measured with H(2)(15)O PET. Anatomical MRI scans were performed on an Elscint 1.9 T Prestige system for PET-MRI coregistration. Significant changes in cerebral blood flow indicating neural activity were detected using an ROI-free image subtraction strategy. In addition, the resting blood flow in patients was correlated with the severity of depression as measured by HAM-D scores. Depressed patients showed decreases in blood flow in right anterior cingulate (Brodmann areas 24 and 32) and increased blood flow in left and right posterior cingulate (Brodmann areas 23, 29, 30), left parahippocampal gyrus (Brodmann area 36), and right caudate compared with healthy volunteers. The severity of depression was inversely correlated with the left middle and inferior frontal gyri (Brodmann areas 9 and 47) and right medial frontal gyrus (Brodmann area 10) and right anterior cingulate (Brodmann areas 24, 32) blood flow, and directly correlated with the right thalamus blood flow. These findings support previous reports of abnormalities in the resting state blood flow in the limbic-frontal structures in depressed patients compared to healthy volunteers.
authors.affiliation: Department of Psychiatry, The University of Texas Health Science Center at San Antonio (UTHSCSA), Texas, USA.
authors.forename: E Serap
authors.initials: ES
authors.lastname: Monkul
authors.forename: Leandro A P
authors.initials: LA
authors.lastname: Silva
authors.forename: Shalini
authors.initials: S
authors.lastname: Narayana
authors.forename: Marco A M
authors.initials: MA
authors.lastname: Peluso
authors.forename: Frank
authors.initials: F
authors.lastname: Zamarripa
authors.forename: Fabiano G
authors.initials: FG
authors.lastname: Nery
authors.forename: Pablo
authors.initials: P
authors.lastname: Najt
authors.forename: John
authors.initials: J
authors.lastname: Li
authors.forename: Jack L
authors.initials: JL
authors.lastname: Lancaster
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.forename: Beny
authors.initials: B
authors.lastname: Lafer
authors.forename: Jair C
authors.initials: JC
authors.lastname: Soares
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography / Q000379:methods; D017397:Prefrontal Cortex / Q000098:blood supply; D012039:Regional Blood Flow
chemical_list: D010104:Oxygen Radioisotopes