title: Successful management of chronic multifocal Q fever Osteomyelitis with adjuvant interferon-gamma therapy.
abstract: We present a 3-year-old girl who had chronic recurrent multifocal osteomyelitis caused by Coxiella burnetii despite long-term dual antibiotic therapy. Excellent clinical response was achieved and sustained when immunomodulatory therapy with interferon-γ was initiated. This is the case of a first child who was successfully treated with interferon-γ as adjuvant therapy for chronic multifocal Q fever osteomyelitis.
authors.affiliation: Division of Pediatric Infectious Diseases, Hospital Universitario Infantil Virgen del Rocio, Sevilla, Spain.
authors.forename: Olaf Werner
authors.initials: OW
authors.lastname: Neth
authors.forename: Dolores
authors.initials: D
authors.lastname: Falcon
authors.forename: Estrella
authors.initials: E
authors.lastname: Peromingo
authors.forename: Maria
authors.initials: M
authors.lastname: Soledad Camacho
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodríguez-Gallego
authors.forename: Ignacio
authors.initials: I
authors.lastname: Obando
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D016997:Coxiella burnetii; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000627:therapeutic use*; D010019:Osteomyelitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D011778:Q Fever / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D007155:Immunologic Factors; D007371:Interferon-gamma