title: Red blood cell transfusion following burn.
abstract: A severe burn will significantly alter haematologic parameters, and manifest as anaemia, which is commonly found in patients with greater than 10% total body surface area (TBSA) involvement. Maintaining haemoglobin and haematocrit levels with blood transfusion has been the gold standard for the treatment of anaemia for many years. While there is no consensus on when to transfuse, an increasing number of authors have expressed that less blood products should be transfused. Current transfusion protocols use a specific level of haemoglobin or haematocrit, which dictates when to transfuse packed red blood cells (PRBCs). This level is known as the trigger. There is no one 'common trigger' as values range from 6 g dl(-1) to 8 g dl(-1) of haemoglobin. The aim of this study was to analyse the current status of red blood cell (RBC) transfusions in the treatment of burn patients, and address new information regarding burn and blood transfusion management. Analysis of existing transfusion literature confirms that individual burn centres transfuse at a lower trigger than in previous years. The quest for a universal transfusion trigger should be abandoned. All RBC transfusions should be tailored to the patient's blood volume status, acuity of blood loss and ongoing perfusion requirements. We also focus on the prevention of unnecessary transfusion as well as techniques to minimise blood loss, optimise red cell production and determine when transfusion is appropriate.
authors.affiliation: Civico and Benfratelli Hospital Burn Center, Palermo, Italy. giuseppecuringa@venuslab.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Curinga
authors.forename: Amit
authors.initials: A
authors.lastname: Jain
authors.forename: Michael
authors.initials: M
authors.lastname: Feldman
authors.forename: Mark
authors.initials: M
authors.lastname: Prosciak
authors.forename: Bradley
authors.initials: B
authors.lastname: Phillips
authors.forename: Stephen
authors.initials: S
authors.lastname: Milner
mesh_terms: D002056:Burns / Q000097:blood / Q000628:therapy*; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000592:standards*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D010818:Practice Patterns, Physicians'
chemical_list: D006454:Hemoglobins