title: [TTF-1: neither angel nor demon].
abstract: Expressed in thyroid, lung and diencephalon, the Thyroid transcription factor-1 (TTF-1) regulates, in these organs, the transcription of specific genes. This review focuses on the use of TTF-1 as a diagnostic tool in thyroid and lung carcinomas. According to the literature, TTF-1 seems to be involved in aggressive relapses. In some cases it could be also involved in the remission. The use of TTF-1 as a prognostic tool for some neoplasms is discussed.
authors.affiliation: Institut Gustave Roussy, UMR 8203 CNRS, Laboratoire de vectorologie et thérapeutiques anticancéreuses, 114, rue Édouard Vaillant, 94805 Villejuif, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Gilbert-Sirieix
authors.forename: Liliane
authors.initials: L
authors.lastname: Massaad-Massade
mesh_terms: D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000209:etiology; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; C504003:TTF1 protein, human; D014157:Transcription Factors