title: Xiang-qi-tang increases avian pathogenic Escherichia coli-induced survival rate and regulates serum levels of tumor necrosis factor alpha, interleukin-1 and soluble endothelial protein C receptor in chicken.
abstract: Xiang-qi-tang (XQT) is a Chinese herbal formula containing rhizoma Cyperi, Andrographis paniculata and Astragalus membranaceus. The present study investigated the effects of XQT on the mortality and inflammatory mediators in a chicken model challenged with avian pathogenic Escherichia coli (APEC). To detect the effect of XQT, the chickens were pretreated with the formula 12 h before being challenged with 10(8) colony forming unit (CFU) of APEC. The results showed that 0.6 g/kg XQT significantly elevated the survival rate of infected chickens. To further investigate the mechanism of decreasing mortality of XQT, we examined plasma inflammatory mediator levels. The levels of tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1) and soluble endothelial protein C receptor (sEPCR) were significantly increased in chickens challenged with APEC alone, whereas chickens pretreated with 0.6 g/kg XQT showed marked decrease of these inflammatory mediator levels during the death peak. Taken together, this study demonstrates that XQT has protective effects in APEC-treated chickens. The action mechanisms of XQT involve anti-inflammation and antithrombotic activity. These findings may contribute to future research on the action mechanisms of this formula, as well as prevention of or therapy for avian colibacillosis.
authors.affiliation: Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, PR China.
authors.forename: Chang-Liang
authors.initials: CL
authors.lastname: He
authors.forename: Ben-Dong
authors.initials: BD
authors.lastname: Fu
authors.forename: Hai-Qing
authors.initials: HQ
authors.lastname: Shen
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Jiang
authors.forename: Chang-Shuai
authors.initials: CS
authors.lastname: Zhang
authors.forename: Shuai-Cheng
authors.initials: SC
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Xu-Bin
authors.initials: XB
authors.lastname: Wei
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001779:Blood Coagulation Factors; D002645:Chickens; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000097:blood / Q000188:drug therapy / Q000401:mortality / Q000662:veterinary*; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018836:Inflammation Mediators / Q000097:blood*; D007375:Interleukin-1 / Q000097:blood; D008517:Phytotherapy; D010946:Plants, Medicinal; D011201:Poultry Diseases / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D011956:Receptors, Cell Surface / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D001779:Blood Coagulation Factors; D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D018836:Inflammation Mediators; D007375:Interleukin-1; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha; C091963:activated protein C receptor