title: Albumin synthesis rates in post-surgical infants and septic adolescents; influence of amino acids, energy, and insulin.
abstract: OBJECTIVE
  To investigate the effects of glucose, parenteral amino acids, and intravenous insulin on albumin synthesis rates in critically ill children.
  
  
  METHODS
  Two studies were performed in 8 post-surgical infants (age 9.8 ± 1.9 months; weight 9.5 ± 1.1 kg) and 9 septic adolescents (age 15 ± 1 yr; BMI 23 ± 4 kg m(-2)), respectively. All received a primed, constant, tracer infusion with [1-(13)C]Leucine. The infants in study 1 were randomized to receive low (2.5 mg kg(-1) min(-1)) and standard (5.0 mg kg(-1) min(-1)) glucose intake in a cross-over setting of two periods of 4 h each. The adolescents in study 2 were randomized to receive total parenteral nutrition with standard (1.5 g kg(-1) day(-1)) and high (3.0 g kg(-1) day(-1)) amino acid intake in a two day cross-over setting. On both study days, during the last 3 h of the tracer study, they received insulin infused at 80 mU m(-2) min(-1).
  
  
  RESULTS
  The post-surgical infants and the septic adolescents were mildly hypoalbuminemic (∼2.5 g dL(-1)) with high synthesis rates, which were not affected by different intakes of glucose, amino acids, or insulin infusion.
  
  
  CONCLUSIONS
  Albumin synthesis rates in hypoalbuminemic critically ill children are high but were not upregulated through nutrient supply, and in septic adolescents are unaffected by insulin.
authors.affiliation: Department of Pediatrics, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands. S.verbruggen@erasmusmc.nl
authors.forename: Sascha C
authors.initials: SC
authors.lastname: Verbruggen
authors.forename: Henk
authors.initials: H
authors.lastname: Schierbeek
authors.forename: Jorge
authors.initials: J
authors.lastname: Coss-Bu
authors.forename: Koen F M
authors.initials: KF
authors.lastname: Joosten
authors.forename: Leticia
authors.initials: L
authors.lastname: Castillo
authors.forename: Johannes B
authors.initials: JB
authors.lastname: van Goudoever
mesh_terms: D000293:Adolescent; D000418:Albumins / Q000096:biosynthesis*; D000596:Amino Acids / Q000008:administration & dosage*; D001786:Blood Glucose / Q000032:analysis; D016638:Critical Illness; D018592:Cross-Over Studies; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006706:Homeostasis; D006801:Humans; D006946:Hyperinsulinism / Q000188:drug therapy; D007223:Infant; D007328:Insulin / Q000008:administration & dosage*; D007333:Insulin Resistance; D015278:Intensive Care Units, Pediatric; D007930:Leucine / Q000378:metabolism; D008297:Male; D010289:Parenteral Nutrition, Total; D018805:Sepsis / Q000473:pathology / Q000628:therapy*
chemical_list: D000418:Albumins; D000596:Amino Acids; D001786:Blood Glucose; D007328:Insulin; D007930:Leucine; D005947:Glucose