title: Neurodegenerative disease and adult neurogenesis.
abstract: The generation and cell death of newly generated cells have critical roles in brain development and maintenance in the embryonic and adult brain. Alterations in these processes are also seen in neurodegenerative diseases. Genes that are key players in neurodegenerative diseases (α-synuclein, presenilin-1, tau, huntingtin) are also physiologically involved in modulating brain plasticity. Interestingly, in some neurodegenerative diseases, the specific alterations in neurogenic areas such as the dentate gyrus and subventricular zone/olfactory bulb system parallel the early or premotor symptoms that are seen in the early stages of these diseases, such as depression, anxiety or olfactory dysfunction. We will review the modulation of neurogenesis in animal models and human brains of Parkinson's disease, Huntington's disease and Alzheimer's disease.
authors.affiliation: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Beate
authors.initials: B
authors.lastname: Winner
authors.forename: Zacharias
authors.initials: Z
authors.lastname: Kohl
authors.forename: Fred H
authors.initials: FH
authors.lastname: Gage
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology*; D000818:Animals; D030801:Animals, Genetically Modified; D001921:Brain / Q000166:cytology / Q000473:pathology / Q000502:physiology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000503:physiopathology*; D055495:Neurogenesis / Q000502:physiology*