title: Frequency of intracranial aneurysms in patients with spontaneous intracranial hypotension.
abstract: OBJECTIVE
  Spontaneous intracranial hypotension (SIH) is a significant cause of new-onset daily persistent headache. A generalized connective tissue disorder also involving the intracranial arteries has been suspected in the population with SIH. Therefore, the authors reviewed angiographic studies for the presence of intracranial aneurysms in a group of patients with SIH.
  
  
  METHODS
  Magnetic resonance angiography studies of the brain were performed in 93 patients with SIH (mean age 43 years, range 14-86 years) and in 291 controls (mean age 56 years, range 28-78 years).
  
  
  RESULTS
  Intracranial aneurysms were detected in 8 (8.6%) of the 93 patients with SIH (95% CI 2.9%-14.3%). This incidence was higher than in the control population (3 (1.0%) of 291 (95% CI 0%-2.2%; p = 0.0007). In 7 patients the aneurysms were incidental, and in 1 patient SIH developed 5 weeks after an aneurysmal subarachnoid hemorrhage.
  
  
  CONCLUSIONS
  In this retrospective case-control study, the frequency of intracranial aneurysms among patients with SIH was significantly higher than in the control population.
authors.affiliation: Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 West Third Street, Suite 800E, Los Angeles, California 90048, USA. SchievinkW@cshs.org
authors.forename: Wouter I
authors.initials: WI
authors.lastname: Schievink
authors.forename: M Marcel
authors.initials: MM
authors.lastname: Maya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D002532:Intracranial Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D019585:Intracranial Hypotension / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult