title: The correlation between the clinical laboratory data and the telomere length in peripheral blood leukocytes of Japanese female patients with hypertension.
abstract: OBJECTIVE
  This study investigated the correlation between the chronological age, telomere length in peripheral blood leukocytes and blood laboratory data of female patients with mild hypertension to identify laboratory data that reflect the biological aging of individuals.
  
  
  METHODS
  Cross-sectional population-based study.
  
  
  METHODS
  Outpatient clinic of the Department of Cardiovascular, Respiratory, and Geriatric Medicine Kyushu University Hospital at Beppu in Japan.
  
  
  METHODS
  Outpatients with mild hypertension treated with a low dose of amlodipine.
  
  
  METHODS
  The laboratory data of female patients were collected and the telomere length parameters in their peripheral blood leukocytes were determined by Southern blotting. Any correlations between the laboratory data and the telomere length parameters were assessed.
  
  
  RESULTS
  The patients showed a positive correlation between the telomere length and the high density lipoprotein, albumin, creatinine, hemoglobin levels, red blood cell counts, and a negative correlation with the globulin level. The extent of subtelomeric methylation of long telomeres tended to correlate negatively with the telomeric attrition. Only the creatinine level correlated with subtelomeric methylation, but not with telomeric length.
  
  
  CONCLUSIONS
  HDL and the albumin/globulin ratio were potential indicators for individual somatic genomic aging. Creatinine may therefore be a useful indicator for a predisposition for telomeric attrition.
authors.affiliation: The Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Oita, 874-0838, Japan. maedat@beppu.kyushu-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: J-I
authors.initials: JI
authors.lastname: Oyama
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Arima
authors.forename: N
authors.initials: N
authors.lastname: Makino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D017311:Amlodipine / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D015139:Blotting, Southern; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D007564:Japan; D007962:Leukocytes; D008745:Methylation; D008875:Middle Aged; D016615:Telomere / Q000737:chemistry* / Q000235:genetics
chemical_list: D000959:Antihypertensive Agents; D017311:Amlodipine; D003404:Creatinine