title: Synthesis and in vitro studies of biodegradable thiolated chitosan hydrogels for breast cancer therapy.
abstract: Local drug delivery strategies have gained momentum recently as a promising modality in cancer therapy. In order to deliver Letrozole (LTZ) at the tumor site in therapeutically relevant concentrations, acetyl-polyamidoamine (Ac-PAMAM)-thiolated chitosan (TCS) films were fabricated. LTZ could be loaded at 31% wt/wt in films, which were translucent and flexible. Physicochemical characterization of LTZ via thermal technique revealed information on solid-state properties of LTZ as well as thiolated chitosan in films. While thiolated chitosan was in amorphous form, LTZ seemed to be present in both amorphous and crystalline forms in film. The lack of formulation-induced local inflammatory responses of LTZ-acetyl-polyamidoamine (Ac-PAMAM)-thiolated chitosan (TCS) films a new paradigm for localized chemotherapy based on breast delivery systems.
authors.affiliation: Nanostructured Materials Synthesis Laboratory, International Research Institute of Arian Chemie Gostar, Tabriz, Iran. saboktakin123@yahoo.com
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Saboktakin
authors.forename: Roya M
authors.initials: RM
authors.lastname: Tabatabaie
authors.forename: Abel
authors.initials: A
authors.lastname: Maharramov
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Ramazanov
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000628:therapy; D002626:Chemistry, Pharmaceutical / Q000379:methods; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D004355:Drug Stability; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D000077289:Letrozole; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D009570:Nitriles / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013718:Tensile Strength / Q000502:physiology; D014230:Triazoles / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D020100:Hydrogels; D009570:Nitriles; D013438:Sulfhydryl Compounds; D014230:Triazoles; D000077289:Letrozole; D048271:Chitosan