title: Protective effect of kombucha mushroom (KM) tea on phenol-induced cytotoxicity in albino mice.
abstract: The present study was carried out to evaluate the protective role of kombucha mushroom (KM) tea on cytotoxicity induced by phenol (PHE) in mice. We used weight gain and micronucleus (MN) frequency as indicators of cytotoxicity and supported these parameters with pathological findings. The animals were randomly divided into seven groups: (Group I) only tap water (Group II) 1000 microl kg(-1) b. wt KM-tea, (Group III) 35 mg kg(-1) body wt. PHE (Group IV) 35 mg kg(-1) body wt. PHE + 250 microl kg(-1) b. wt KM-tea (Group V) 35 mg kg(-1) b. wt PHE + 500 microl kg(-1) b. wt KM-tea (Group VI) 35 mg kg(-1) b. wt PHE + 750 microl kg(-1) b. wt KM-tea, (Group VII) 35 mg kg(-1) b. wt PHE + 1000 microl kg(-1) b. wt KM-tea, for 20 consecutive days by oral gavage. The results indicated that all KM-tea supplemented mice showed a lower MN frequency than erythrocytes in only PHE-treated group. There was an observable regression on account of lesions in tissues of mice supplemented with different doses of KM-tea in histopathological observations. In conclusion, the KM-tea supplementation decreases cytotoxicity induced by PHE and its protective role is dose-dependent.
authors.affiliation: Department of Medical Pharmacology, Internal Medical Sciences Division, Faculty of Medicine, Giresun University, 28100, Giresun, Turkey. k_yapar@hotmail.com
authors.forename: Kursad
authors.initials: K
authors.lastname: Yapar
authors.forename: Kultigin
authors.initials: K
authors.lastname: Cavusoglu
authors.forename: Ertan
authors.initials: E
authors.lastname: Oruc
authors.forename: Emine
authors.initials: E
authors.lastname: Yalcin
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D001628:Beverages / Q000032:analysis*; D006321:Heart / Q000187:drug effects; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009206:Myocardium / Q000473:pathology; D019800:Phenol / Q000633:toxicity*; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects / Q000473:pathology
chemical_list: D020011:Protective Agents; D019800:Phenol