title: Metal ion sensors based on DNAzymes and related DNA molecules.
abstract: Metal ion sensors are an important yet challenging field in analytical chemistry. Despite much effort, only a limited number of metal ion sensors are available for practical use because sensor design is often a trial-and-error-dependent process. DNAzyme-based sensors, in contrast, can be developed through a systematic selection that is generalizable for a wide range of metal ions. Here, we summarize recent progress in the design of DNAzyme-based fluorescent, colorimetric, and electrochemical sensors for metal ions, such as Pb(2+), Cu(2+), Hg(2+), and UO(2)(2+). In addition, we also describe metal ion sensors based on related DNA molecules, including T-T or C-C mismatches and G-quadruplexes.
authors.affiliation: State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. xbzhang@hnu.cn
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Zhang
authors.forename: Rong-Mei
authors.initials: RM
authors.lastname: Kong
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
mesh_terms: D015374:Biosensing Techniques; D003124:Colorimetry; D004247:DNA / Q000737:chemistry*; D021881:DNA, Catalytic / Q000737:chemistry*; D004563:Electrochemistry; D005453:Fluorescence; D008670:Metals / Q000737:chemistry*
chemical_list: D021881:DNA, Catalytic; D008670:Metals; D004247:DNA