title: Premature ovarian failure.
abstract: Premature ovarian failure (POF) is the occurrence of amenorrhoea, elevated gonadotrophins and hypoestrogenism in women under 40 years of age. It has important physical and psychological consequences and is increasingly common due to improved survival following treatment for malignancy. Despite this, it remains a poorly understood condition. Here we review the presentation and investigation of POF, discuss recent advances in the management of affected women, and suggest how our knowledge of the condition could be improved.
authors.affiliation: Chelsea and Westminster Hospitals, London, UK.
authors.forename: Kate
authors.initials: K
authors.lastname: Maclaran
authors.forename: Nick
authors.initials: N
authors.lastname: Panay
mesh_terms: D002318:Cardiovascular Diseases / Q000517:prevention & control; D003072:Cognition Disorders / Q000517:prevention & control; D003268:Contraception Behavior; D003376:Counseling; D005260:Female; D005298:Fertility; D020249:Hormone Replacement Therapy; D006801:Humans; D008019:Life Style; D010024:Osteoporosis / Q000517:prevention & control; D016649:Primary Ovarian Insufficiency / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D012735:Sexual Dysfunction, Physiological / Q000209:etiology / Q000628:therapy; D020018:Sexual Dysfunctions, Psychological / Q000209:etiology / Q000628:therapy