title: Assessment of elastosis in invasive ductal carcinoma of the breast compared to fibroadenoma among Sudanese patients using conventional histochemical methods.
abstract: We aimed to identify, using histochemical methods, the degree of elastosis in a malignant breast tumor compared to a benign tumor. Sixty-four tissue blocks were used in this study of which 34 (53.1%) were Invasive ductal carcinoma (IDC) (cases) and 30 (46.8%) were fibroadenomas (controls). Examination of Verhoeff's stained sections revealed different grades of elastosis in 29 (85.2%) cases compared to seven (23.3%) in controls. These findings indicated that elastosis was a prominent feature of IDC (p < 0.000). IDC was associated with more frequent occurrence of different grades of elastosis and should, therefore, be considered a valuable histological finding. Nevertheless, more advanced technology for quantitative measurements of the staining density is recommended to confirm this variation.
authors.affiliation: Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan. yosifzakot@yahoo.com
authors.forename: Yosef Mohamed-Azzam
authors.initials: YM
authors.lastname: Zakout
authors.forename: Sara Mohammed
authors.initials: SM
authors.lastname: Abdullah
authors.forename: Marwa Alhaj
authors.initials: MA
authors.lastname: Ali
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D003240:Connective Tissue Diseases / Q000453:epidemiology / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology*; D005260:Female; D018226:Fibroadenoma / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D013397:Sudan / Q000453:epidemiology