title: Ceramide in lipid emulsions used in parenteral nutrition: an innocent bystander?
abstract: Parenteral nutrition-associated liver disease is a prevalent and severe complication of long term parenteral nutrition. We present here for the first time data on the presence of ceramide, a bioactive compound involved in a variety of metabolic processes, in different lipid emulsions used in parenteral nutrition. Further research is needed to determine whether this potential harmful bioactive compound is involved in parenteral nutrition-associated liver disease.
authors.affiliation: Department of Medical Biochemistry, Academic Medical Center, Amsterdam, the Netherlands. j.e.groener@amc.uva.nl
authors.forename: Johanna E
authors.initials: JE
authors.lastname: Groener
authors.forename: Mireille J
authors.initials: MJ
authors.lastname: Serlie
authors.forename: Aldi
authors.initials: A
authors.lastname: Poppema
authors.forename: Mina
authors.initials: M
authors.lastname: Mirzaian
authors.forename: Johannes M
authors.initials: JM
authors.lastname: Aerts
mesh_terms: D002518:Ceramides / Q000032:analysis*; D005217:Fat Emulsions, Intravenous / Q000737:chemistry*; D006801:Humans; D008107:Liver Diseases / Q000209:etiology*; D010288:Parenteral Nutrition / Q000009:adverse effects*
chemical_list: D002518:Ceramides; D005217:Fat Emulsions, Intravenous