title: Functional modeling of the shift in cellular calcium dynamics at the onset of synchronization in smooth muscle cells.
abstract: In the present paper we address the nature of synchronization properties found in populations of mesenteric artery smooth muscle cells. We present a minimal model of the onset of synchronization in the individual smooth muscle cell that is manifested as a transition from calcium waves to whole-cell calcium oscillations. We discuss how different types of ion currents may influence both amplitude and frequency in the regime of whole-cell oscillations. The model may also explain the occurrence of mixed-mode oscillations and chaotic oscillations frequently observed in the experimental system.
authors.affiliation: Department of Physics, Saratov State University, Astrakhanskaya Str. 83, Saratov, 410026, Russia.
authors.forename: D E
authors.initials: DE
authors.lastname: Postnov
authors.forename: J C Brings
authors.initials: JC
authors.lastname: Jacobsen
authors.forename: N-H
authors.initials: NH
authors.lastname: Holstein-Rathlou
authors.forename: O V
authors.initials: OV
authors.lastname: Sosnovtseva
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D025461:Feedback, Physiological; D055641:Mathematical Concepts; D008954:Models, Biological; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D017711:Nonlinear Dynamics; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000378:metabolism