title: Isolation and evaluation of a polysaccharide from Prunus amygdalus as a carrier for transbuccosal delivery of Losartan potassium.
abstract: An oral buccoadhesive drug delivery system for Losartan potassium using a hydrophilic polysaccharide, isolated from Prunus amygdalaus (Badam gum), was developed and evaluated for its potential to overcome the drawbacks associated with the conventional drug therapy. The results of the study indicate that the isolated polysaccharide has good physicochemical and morphological characteristics and is suitable for use as a mucoadhesive sustain release polymer in pharmaceutical dosage forms, to alleviate the drawbacks of the conventional drug therapy of Losartan potassium.
authors.affiliation: Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ootacamund, India.
authors.forename: M J N
authors.initials: MJ
authors.lastname: Chandrasekar
authors.forename: S Mahesh
authors.initials: SM
authors.lastname: Kumar
authors.forename: D
authors.initials: D
authors.lastname: Manikandan
authors.forename: M J
authors.initials: MJ
authors.lastname: Nanjan
mesh_terms: D000278:Administration, Buccal; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D016503:Drug Delivery Systems; D005260:Female; D019808:Losartan / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000633:toxicity / Q000648:ultrastructure; D027861:Prunus / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004337:Drug Carriers; D011134:Polysaccharides; D019808:Losartan