title: Newly identified prions in budding yeast, and their possible functions.
abstract: Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. [PSI+], [URE3], and [PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including [SWI+], [OCT+], [MCA], [GAR+], [MOT3+], [ISP+], and [NSI+]. The growing number of yeast prions suggests that protein-based inheritance might be a widespread biological phenomenon. In this review, we summarize the characteristics of each prion element, and discuss their potential functional roles in yeast biology.
authors.affiliation: Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Chicago, IL 60611, USA. e-crow@northwestern.edu
authors.forename: Emily T
authors.initials: ET
authors.lastname: Crow
authors.forename: Liming
authors.initials: L
authors.lastname: Li
mesh_terms: D000682:Amyloid / Q000378:metabolism*; D020169:Caspases / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D057890:Epigenomics; D005979:Glutathione Peroxidase / Q000378:metabolism; D010454:Peptide Termination Factors / Q000378:metabolism; D011328:Prions / Q000737:chemistry* / Q000378:metabolism*; D006180:Proton-Translocating ATPases / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000378:metabolism*; D004718:Saccharomycetales / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D000682:Amyloid; C065455:CYC8 protein, S cerevisiae; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; C112006:MOT3 protein, S cerevisiae; D010454:Peptide Termination Factors; D011328:Prions; C404807:RNQ1 protein, S cerevisiae; D012097:Repressor Proteins; C117421:SFP1 protein, S cerevisiae; C068068:SUP35 protein, S cerevisiae; C078562:SWI1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D005979:Glutathione Peroxidase; C067020:URE2 protein, S cerevisiae; D020169:Caspases; C456272:MCA1 protein, S cerevisiae; C092477:PMA1 protein, S cerevisiae; D006180:Proton-Translocating ATPases