title: Hydrogen sulfide-mediated myocardial pre- and post-conditioning.
abstract: Coronary artery disease is a major cause of morbidity and mortality in the Western world. Acute myocardial infarction, resulting from coronary artery atherosclerosis, is a serious and often fatal consequence of coronary artery disease, resulting in cell death in the myocardium. Pre- and post-conditioning of the myocardium are two treatment strategies that reduce the amount of cell death significantly. Hydrogen sulfide has recently been identified as a potent cardioprotective signaling molecule, which is a highly effective pre- and post-conditioning agent. The cardioprotective signaling pathways involved in hydrogen sulfide-based pre- and post-conditioning will be explored in this article.
authors.affiliation: Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Predmore
authors.forename: David J
authors.initials: DJ
authors.lastname: Lefer
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000378:metabolism* / Q000627:therapeutic use; D003331:Coronary Vessels / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism* / Q000627:therapeutic use; D057775:Ischemic Postconditioning / Q000379:methods; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002316:Cardiotonic Agents; D006862:Hydrogen Sulfide