title: Fixed drug eruption caused by mefenamic acid: a case series and diagnostic algorithms.
abstract: BACKGROUND
  Fixed drug eruption is a fairly common drug-induced hypersensitivity reaction of the skin and the mucous membranes, which is characterized by the re-occurrence of the lesion(s) exactly on the previously involved sites after repeated administration. The pathogenetic mechanisms of this site-specificity are not fully elucidated.
  
  
  METHODS
  We report on three cases of fixed drug eruption, including a non-pigmenting generalized bullous fixed drug eruption, caused by mefenamic acid in its pure form.
  
  
  CONCLUSIONS
  Provocation tests with the assumed causative drug represent the gold standard for establishing the diagnosis and for identifying the culprit. Advantages and pitfalls of topical and systemic provocation tests as diagnostic approaches are discussed.
authors.affiliation: Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Vienna. alessandra.handisurya@meduniwien.ac.at
authors.forename: Alessandra
authors.initials: A
authors.lastname: Handisurya
authors.forename: Katharina Barbara
authors.initials: KB
authors.lastname: Moritz
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Riedl
authors.forename: Christina
authors.initials: C
authors.lastname: Reinisch
authors.forename: Georg
authors.initials: G
authors.lastname: Stingl
authors.forename: Stefan
authors.initials: S
authors.lastname: Wöhrl
mesh_terms: D000328:Adult; D000465:Algorithms; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008528:Mefenamic Acid / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008528:Mefenamic Acid