title: Automated immunoassay for reliable measurement of sex hormone binding globulin (SHBG).
abstract: BACKGROUND
  Sex hormone binding globulin (SHBG) is important for the transport and regulation of distribution of sex steroids.
  
  
  METHODS
  The performance of the Architect SHBG automated immunoassay in comparison to radioimmunoassay was evaluated using 62 patient specimens. Furthermore, specimen from 100 healthy individuals were used to establish a preliminary reference interval for this automated assay.
  
  
  RESULTS
  The assay has demonstrated overall good analytical performance and was significantly correlated with the reference method.
  
  
  CONCLUSIONS
  The Architect SHBG assay is a good method for routine measurement of SHBG circulating levels.
authors.affiliation: Department of Laboratory Medicine, Cliniques Universitaires St-Luc, 1200 Brussels, Belgium. damien.gruson@uclouvain.be
authors.forename: D
authors.initials: D
authors.lastname: Gruson
authors.forename: D
authors.initials: D
authors.lastname: Maisin
authors.forename: C
authors.initials: C
authors.lastname: Fillee
mesh_terms: D005060:Europe; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D008297:Male; D012015:Reference Standards; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*
chemical_list: D012738:Sex Hormone-Binding Globulin