title: Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice.
abstract: The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract.
authors.affiliation: Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. tohrus@nutr.med.tokushima-u.ac.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Sakai
authors.forename: Sakina
authors.initials: S
authors.lastname: Furoku
authors.forename: Mariko
authors.initials: M
authors.lastname: Nakamoto
authors.forename: Emi
authors.initials: E
authors.lastname: Shuto
authors.forename: Toshio
authors.initials: T
authors.lastname: Hosaka
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nishioka
authors.forename: Saburo
authors.initials: S
authors.lastname: Sone
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003092:Colitis / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology; D016264:Dextran Sulfate / Q000009:adverse effects; D004195:Disease Models, Animal; D060754:Equol; D005260:Female; D019833:Genistein / Q000009:adverse effects / Q000494:pharmacology; D016753:Interleukin-10 / Q000096:biosynthesis; D007529:Isoflavones / Q000009:adverse effects* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: C007610:4',7-dihydroxy-3,4-dihydroisoflavone; D007529:Isoflavones; D016753:Interleukin-10; D060754:Equol; C004742:daidzein; D016264:Dextran Sulfate; D019833:Genistein