title: Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives.
abstract: Eight new gold(III) complexes (1-8) of 5-aryl-3-(pyridin-2-yl)-4,5-dihydropyrazole-1-carbothioamide have been synthesized and characterized by elemental analysis, molar conductivity, IR, UV, 1H NMR, 13C NMR, MS, and thermal analysis techniques. The cytotoxicity was tested by MTT assay. The results indicate that the complexes 1-8 exert cytotoxic effects against HeLa and A549 cell lines. Moreover, the complexes 1, 4, 5, 7 and 8 have higher cytotoxicity than cisplatin against HeLa cell line. It suggests that the substituent groups on benzene have important effect on cytotoxicity.
authors.affiliation: Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei, PR China. wsx@hbu.edu.cn
authors.forename: Shuxiang
authors.initials: S
authors.lastname: Wang
authors.forename: Wenqing
authors.initials: W
authors.lastname: Shao
authors.forename: Hongdong
authors.initials: H
authors.lastname: Li
authors.forename: Cui
authors.initials: C
authors.lastname: Liu
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Jinchao
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D050607:Organogold Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013696:Temperature; D013854:Thioamides / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: C559799:4,5-dihydropyrazole-1-carbothioamide; D000970:Antineoplastic Agents; D008024:Ligands; D050607:Organogold Compounds; D011720:Pyrazoles; D013854:Thioamides; D006046:Gold