title: Fluorescent water soluble polymers for isozyme-selective interactions with matrix metalloproteinase-9.
abstract: Matrix metalloproteinases (MMPs) are overexpressed in various pathological conditions, including cancers. Although these isozymes have similar active sites, the patterns of exposed amino acids on their surfaces are different. Herein, we report the synthesis and molecular interactions of two water soluble, fluorescent polymers which demonstrate selective interactions with MMP-9 compared to MMP-7 and -10.
authors.affiliation: Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58102, USA.
authors.forename: Rinku
authors.initials: R
authors.lastname: Dutta
authors.forename: Michael D
authors.initials: MD
authors.lastname: Scott
authors.forename: Manas K
authors.initials: MK
authors.lastname: Haldar
authors.forename: Bratati
authors.initials: B
authors.lastname: Ganguly
authors.forename: D K
authors.initials: DK
authors.lastname: Srivastava
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Friesner
authors.forename: Sanku
authors.initials: S
authors.lastname: Mallik
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D020780:Matrix Metalloproteinase 9 / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D011108:Polymers; D020780:Matrix Metalloproteinase 9