title: Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki-Miyaura cross-coupling.
abstract: A pilot library of 2-aminoimidazole triazoles (2-AITs) was synthesized and assayed against Acinetobacter baumannii and methicillin-resistant Staphylococus aureus (MRSA). Results from these studies show that these new derivatives have improved biofilm dispersal activities as well as antibacterial properties against A. baumannii. With MRSA biofilms they are found to possess biofilm inhibition capabilities at low micromolar concentrations.
authors.affiliation: North Carolina State University, Department of Chemistry, Raleigh, North Carolina 27695-8204, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: Reyes
authors.forename: Robert W
authors.initials: RW
authors.lastname: Huigens
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Su
authors.forename: Michel L
authors.initials: ML
authors.lastname: Simon
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects / Q000502:physiology; D018441:Biofilms; D007093:Imidazoles / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000502:physiology; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D007093:Imidazoles; D014230:Triazoles; C014973:2-aminoimidazole