title: Effects of CYP2C9*1/*13 on the pharmacokinetics and pharmacodynamics of meloxicam.
abstract: OBJECTIVE
  To determine the effects of the CYP2C9*1/*13 genotype on the pharmacokinetics and pharmacodynamics of meloxicam in Korean subjects.
  
  
  METHODS
  Meloxicam (15 mg) was orally administered to 21 healthy Korean volunteers with either the CYP2C9*1/*1 or the CYP2C9*1/*13 genotype. Plasma meloxicam concentrations were analysed by HPLC-UV for 72 h after drug administration. The pharmacodynamic effects of meloxicam were determined by measuring TXB(2) generated in blood.
  
  
  RESULTS
  The AUC(0,∞) and C(max) of meloxicam were 2.43- and 1.46-fold higher in the CYP2C9*1/*13 group than in the CYP2C9*1/*1 group, respectively. The oral clearance of meloxicam was significantly lower in the CYP2C9*1/*13 group (37.9% of wild type) than in the CYP2C9*1/*1 group. The t(1/2) of meloxicam was 1.84-fold longer in the CYP2C9*1/*13 group than in the CYP2C9*1/*1 group. The rate of TXB(2) production was significantly lower in the CYP2C9*1/*13 group than in the CYP2C9*1/*1 group.
  
  
  CONCLUSIONS
  The CYP2C9*1/*13 genotype is associated with decreased metabolism and increased pharmacodynamic effects of meloxicam.
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Jung-Woo
authors.initials: JW
authors.lastname: Bae
authors.forename: Chang-Ik
authors.initials: CI
authors.lastname: Choi
authors.forename: Choon-Gon
authors.initials: CG
authors.lastname: Jang
authors.forename: Seok-Yong
authors.initials: SY
authors.lastname: Lee
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000187:drug effects* / Q000235:genetics; D044466:Asian People; D016861:Cyclooxygenase Inhibitors / Q000493:pharmacokinetics*; D065729:Cytochrome P-450 CYP2C9; D006801:Humans; D008297:Male; D000077239:Meloxicam; D008657:Metabolic Clearance Rate; D011110:Polymorphism, Genetic; D056910:Republic of Korea; D013843:Thiazines / Q000493:pharmacokinetics*; D013844:Thiazoles / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D013843:Thiazines; D013844:Thiazoles; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; D000077239:Meloxicam