title: [Changes in the developmental outcome of very low and extremely low birth weight infants at 24 months' corrected age born in 1997-2007].
abstract: OBJECTIVE
  To describe the incidence of developmental impairments (DI) among very low birth weight (VLBW) infants at 24 months' corrected age, born in perinatal centers in 1997-2007, and evaluate their changing prognosis of intact development.
  
  
  METHODS
  Prospective epidemiological study.
  
  
  METHODS
  Follow-up clinics of neonatal centers level III.
  
  
  METHODS
  Live birth rate, in-hospital mortality, neonatal morbidity, DI and quality of survival were assessed. Neonatal morbidity was analyzed in periods 2000/2, 2003/5, and 2006/7 by the data of Institute of Health Informatics and Statistics. DI and quality of survival were evaluated in cohorts of VLBW infants born in 1997/9 (period I), 2000/2 (period II), 2003/5 (period III) and 2006/7 (period IV).
  
  
  RESULTS
  Live birth rate of VLBW newborns in 1997-2007 increased in total of 39.5%, in-hospital mortality decreased, significantly in 1997-9 (fall of 10%). Neonatal morbidity, except infections, also declined. Significant decrease in DI-CP and visual impairment, was observed after period II, in category 1000-1499 g of 7/1.5%, in infants <1000 g of 8/7% resp. After period II, the prevalence of impaired children 1000-1499 g decreased of 5%, whereas in category < 1000 g only small decrease of 2% occurred in period III. Number of children without impairment increased gradually in both categories.
  
  
  CONCLUSIONS
  The study showed significant increase in surviving VLBW infants, especially in category <1000 g. Increased survival rate at concurrent fall in severe neonatal morbidity (except infections) was not accompanied with worsened prognosis of an intact development.
authors.affiliation: Gynekologicko-porodnicka klinika, Praha. petr.zoban@lfmotol.cuni.cz
authors.forename: P
authors.initials: P
authors.lastname: Zoban
authors.forename: I
authors.initials: I
authors.lastname: Borek
authors.forename: H
authors.initials: H
authors.lastname: Budosová
authors.forename: E
authors.initials: E
authors.lastname: Dortová
authors.forename: J
authors.initials: J
authors.lastname: Hálek
authors.forename: P
authors.initials: P
authors.lastname: Hitka
authors.forename: H
authors.initials: H
authors.lastname: Kubinová
authors.forename: M
authors.initials: M
authors.lastname: Pisová
authors.forename: H
authors.initials: H
authors.lastname: Podesvová
authors.forename: R
authors.initials: R
authors.lastname: Pudíková
authors.forename: B
authors.initials: B
authors.lastname: Tesarová
authors.forename: B
authors.initials: B
authors.lastname: Zlatohlávková
mesh_terms: D002547:Cerebral Palsy / Q000175:diagnosis / Q000209:etiology; D002657:Child Development; D002675:Child, Preschool; D006311:Hearing Disorders / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007226:Infant Mortality; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000401:mortality; D019102:Infant, Very Low Birth Weight; D011379:Prognosis; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology