title: Telomere--the twilight to immortality.
abstract: Besides forming a very important component of the chromosome, the telomeres have extremely significant modes of action and functions, right from maintaining a basic infrastructure and integrity of the chromosome vis a vis the other chromosomes, telomeres are responsible for the cell divisions and replicative senescence of the cell. The number of mitotic divisions which a cell will go through in its life span while passing through the cell cycle is governed inturn by these telomeres, the crux of the entire functioning of these chromosomal components suggests that they are the ticking clocks of the cell and when they diminish or are worn out so does the cell reach it's senility at the fag end of it's replicative life--resulting fate being--the cell is sent to it's grave yard (the final destination). Clinical implications include--regulation of cell life spans, regulating the cell's replicative behavior and it's utility in forming cells which usually are impossible to divide or replicate, telomeres regulate the cloning process,the telomeres play a major role in predicting the fate of a neoplastic cell and finally enhancing the life span of a single cell, the organ, the body as a whole by enzymes which expand the telomeres--the telomerase.
authors.affiliation: Dept. of Pathology, JNMC, DMIMS.
authors.forename: Samarth
authors.initials: S
authors.lastname: Shukla
authors.forename: Sourya
authors.initials: S
authors.lastname: Acharya
authors.forename: Devendra
authors.initials: D
authors.lastname: Rajput
authors.forename: S
authors.initials: S
authors.lastname: Vagha
authors.forename: Shobha
authors.initials: S
authors.lastname: Grover
mesh_terms: D000375:Aging / Q000502:physiology; D000970:Antineoplastic Agents / Q000494:pharmacology; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D002470:Cell Survival; D016922:Cellular Senescence / Q000235:genetics* / Q000502:physiology; D004261:DNA Replication; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000648:ultrastructure; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D019098:Telomerase