title: Synthesis of coumarin-based, esterase-sensitive cyclic prodrugs of opioid peptides with enhanced membrane permeability and enzymatic stability.
abstract: With the discovery of an increasing number of biologically active peptides and peptide mimetics (1-3), there is a pressing need for the development of strategies to deliver these biologically active compounds to the desired site of action. The preceding two chapters have described two methods of making esterase-sensitive cyclic prodrugs of peptides. In this chapter, we wish to describe a third method of making esterase-sensitive cyclic prodrugs of peptides using DADLE, an opioid peptide (4-7), as an example.
authors.affiliation: Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS.
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: D
authors.initials: D
authors.lastname: Shan
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: O
authors.initials: O
authors.lastname: Gudmundsson
authors.forename: R T
authors.initials: RT
authors.lastname: Borchardt