title: Changes in murine hair with dietary selenium excess or deficiency.
abstract: It is known that an excess or deficiency of selenium (Se) causes abnormalities in hair. We evaluated changes in the hair follicles associated with Se imbalance in a C57BL/6 mouse model to better understand the role of Se in hair growth. Fifteen C57BL/6 mice were assigned to diets providing excessive, adequate, or deficient amounts of Se. Alopecia with poliosis was observed in the groups receiving either excessive or deficient selenium. Skin biopsy from alopecia patches showed increased telogen hair follicles with epidermal atrophy. There was a significant decrease of anti-apoptotic Bcl-2 and an increase of pro-apoptotic Bax in the excessive-Se group compared with the adequate group. We suggest that alopecia with poliosis is caused by changes in the hair follicle cycle due to the imbalance of Se and partially influenced by the decrease of the ratio of Bcl-2/Bax, which is associated with induction of apoptosis of keratinocytes.
authors.forename: Seon Wook
authors.initials: SW
authors.lastname: Hwang
authors.forename: Hyun Jae
authors.initials: HJ
authors.lastname: Lee
authors.forename: Kee Suck
authors.initials: KS
authors.lastname: Suh
authors.forename: Sang Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Sung Wook
authors.initials: SW
authors.lastname: Park
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Hur
authors.forename: Deborah
authors.initials: D
authors.lastname: Lee
authors.forename: Jong Keun
authors.initials: JK
authors.lastname: Seo
authors.forename: Ho Suk
authors.initials: HS
authors.lastname: Sung
mesh_terms: D000505:Alopecia / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D017209:Apoptosis; D005260:Female; D019254:Genes, bcl-2; D018859:Hair Follicle / Q000378:metabolism* / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012643:Selenium / Q000172:deficiency / Q000378:metabolism*; D051028:bcl-2-Associated X Protein / Q000235:genetics / Q000378:metabolism
chemical_list: C494826:BAX protein, human; D051028:bcl-2-Associated X Protein; D012643:Selenium