title: Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1).
abstract: OBJECTIVE
  Polymorphisms within the ICAM1 structural gene have been shown to influence circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) but their relation to atherosclerosis has not been clearly established. We sought to determine whether ICAM1 SNPs are associated with circulating sICAM-1 concentration, coronary artery calcium (CAC), and common and internal carotid intima medial thickness (IMT).
  
  
  RESULTS
  3550 black and white Coronary Artery Risk Development in Young Adults (CARDIA) Study subjects who participated in the year 15 and/or 20 examinations and were part of the Young Adult Longitudinal Study of Antioxidants (YALTA) ancillary study were included in this analysis. In whites, rs5498 was significantly associated with sICAM-1 (p<0.001) and each G-allele of rs5498 was associated with 5% higher sICAM-1 concentration. In blacks, each C-allele of rs5490 was associated with 6% higher sICAM-1 level; this SNP was in strong linkage disequilibrium with rs5491, a functional variant. Subclinical measurements of atherosclerosis in either year 15 or year 20 were not significantly related to ICAM1 SNPs.
  
  
  CONCLUSIONS
  In CARDIA, ICAM1 DNA segment variants were associated with sICAM-1 protein level including the novel finding that levels differ by the functional variant rs5491. However, ICAM1 SNPs were not strongly related to either IMT or CAC. Our findings in CARDIA suggest that ICAM1 variants are not major early contributors to subclinical atherosclerosis.
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Harwick Building 6-56, 200 1st Street SW, Rochester, MN 55905, United States. bielinski.suzette@mayo.edu
authors.forename: Suzette J
authors.initials: SJ
authors.lastname: Bielinski
authors.forename: Alex P
authors.initials: AP
authors.lastname: Reiner
authors.forename: Deborah
authors.initials: D
authors.lastname: Nickerson
authors.forename: Chris
authors.initials: C
authors.lastname: Carlson
authors.forename: Kent R
authors.initials: KR
authors.lastname: Bailey
authors.forename: Bharat
authors.initials: B
authors.lastname: Thyagarajan
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Lange
authors.forename: Eric A
authors.initials: EA
authors.lastname: Boerwinkle
authors.forename: David R
authors.initials: DR
authors.lastname: Jacobs
authors.forename: Myron D
authors.initials: MD
authors.lastname: Gross
mesh_terms: D000328:Adult; D000483:Alleles; D000975:Antioxidants / Q000378:metabolism; D050197:Atherosclerosis / Q000235:genetics; D002118:Calcium / Q000378:metabolism; D002339:Carotid Arteries / Q000473:pathology; D015331:Cohort Studies; D003331:Coronary Vessels / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006239:Haplotypes; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
chemical_list: D000975:Antioxidants; D018799:Intercellular Adhesion Molecule-1; D002118:Calcium