title: A relation between near-wall particle-hemodynamics and onset of thrombus formation in abdominal aortic aneurysms.
abstract: A novel computational particle-hemodynamics analysis of key criteria for the onset of an intraluminal thrombus (ILT) in a patient-specific abdominal aortic aneurysm (AAA) is presented. The focus is on enhanced platelet and white blood cell residence times as well as their elevated surface-shear loads in near-wall regions of the AAA sac. The generalized results support the hypothesis that a patient's AAA geometry and associated particle-hemodynamics have the potential to entrap activated blood particles, which will play a role in the onset of ILT. Although the ILT history of only a single patient was considered, the modeling and simulation methodology provided allow for the development of an efficient computational tool to predict the onset of ILT formation in complex patient-specific cases.
authors.affiliation: Physics-Based Computing Group, Southeast Division, Applied Research Associates, Raleigh, NC 27615, USA.
authors.forename: C
authors.initials: C
authors.lastname: Basciano
authors.forename: C
authors.initials: C
authors.lastname: Kleinstreuer
authors.forename: S
authors.initials: S
authors.lastname: Hyun
authors.forename: E A
authors.initials: EA
authors.lastname: Finol
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000503:physiopathology*; D001792:Blood Platelets; D003198:Computer Simulation; D006801:Humans; D007962:Leukocytes; D008955:Models, Cardiovascular; D033081:Shear Strength; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology*