title: Generalized granuloma annulare with open comedones in photoexposed areas.
abstract: Granuloma annulare (GA) is a noninfectious necrobiotic granuloma, which can present as localized or generalized patterns. We present a case of generalized GA with multiple large open comedones over the lesions in a woman with hypothyroidism and diabetes mellitus. GA is associated with collagen and elastic-fibre damage, which may lead to loss of follicular support and resultant open comedone formation, analogous to solar elastosis or senile comedones. The rapid recovery of our patient after treatment with of oral hypoglycaemics supports the role of insulin resistance as a predisposing factor for GA.
authors.affiliation: Skin Institute and School of Dermatology, Greater Kailash, New Delhi, India. drpremanshu@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Bhushan
authors.forename: A
authors.initials: A
authors.lastname: Aggarwal
authors.forename: R
authors.initials: R
authors.lastname: Yadav
authors.forename: V
authors.initials: V
authors.lastname: Baliyan
mesh_terms: D000152:Acne Vulgaris / Q000209:etiology* / Q000473:pathology; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy; D005148:Facial Dermatoses / Q000209:etiology / Q000473:pathology; D005260:Female; D016460:Granuloma Annulare / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007037:Hypothyroidism / Q000150:complications; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects*
chemical_list: D007004:Hypoglycemic Agents