title: 18F-Labeled magnetic-upconversion nanophosphors via rare-Earth cation-assisted ligand assembly.
abstract: A novel method of rare-earth cation-assisted ligand assembly has been developed to provide upconversion nanophosphors with T(1)-enhanced magnetic resonance (MR), radioactivity, and targeted recognition properties, making these nanoparticles potential candidates for multimodal bioimaging. The process of modifying the surface of the nanophosphors has been confirmed by transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, proton nuclear magnetic resonance, Fourier-transform infrared spectroscopy, energy-dispersive X-ray analysis, and so on. The versatility of this surface modification approach for incorporating functional molecules and fabricating fluorine-18-labeled magnetic-upconversion nanophosphors as multimodal bioprobes has been demonstrated by targeted cell imaging, in vivo upconversion luminescence, MR imaging, and positron emission tomography imaging of whole-body small animals.
authors.affiliation: Joint Center of Biomedical Imaging of Department of Chemistry & Institute of Biomedical Science & Cancer Hospital, Advanced Materials Laboratory, Fudan University, 200433, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
authors.forename: Chenguang
authors.initials: C
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Chunyan
authors.initials: C
authors.lastname: Li
authors.forename: Tianshe
authors.initials: T
authors.lastname: Yang
authors.forename: Xianzhong
authors.initials: X
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Yi
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
authors.forename: Fuyou
authors.initials: F
authors.lastname: Li