title: [Effect of linear alkylbenzenesulfonate on the reproductive capacity and life-span of Drosophila melanogaster].
abstract: OBJECTIVE
  To investigate the effect of linear alkylbenzenesulfonate (LAS) on the reproductive capacity and life-span of Drosophila melanogaster.
  
  
  METHODS
  Drosophila melanogaster images within 8 h after eclosion were collected with ether anesthesia. The female and male of similar size and normal shape and behavior were selected. The Drosophila melanogasters were cultured in the culture medium containing LAS of different densities. We divided the Drosophila melanogaster into 4 groups according to LAS concentrations: a low dose group with LAS 150 mg/kg, a middle dose group with LAS 300 mg/kg,a high dose group with LAS 600 mg/kg, and a control group without LAS, respectively. The changes of the reproductive capacity, median lethal time, mean life-span and max mean life-span of drosophila melanogaster with different doses of LAS were measured and compared with those of the control.
  
  
  RESULTS
  The pupa numbers of filial generation of Drosophila melanogaster in the low, middle, and high dose groups (85.07%, 84.59% and 71.88%, respectively) were lower than those in the control group (P<0.01). The median lethal time, mean life-span and max mean life-span of Drosophila melanogaster in the low, middle, and high dose groups were shorter than those in the control group (P<0.05). The change of life-span of Drosophila melanogaster in the high dose group was remarkable: the median lethal time of female and male shortened 13 days and 15 days, the mean life-span of female and male shortened 18 days and 14 days, and the max mean life-span of female and male shortened 14 days and 12 days, respectively.
  
  
  CONCLUSIONS
  LAS has definite toxicity to Drosophila melanogaster, which can degrade the reproductive capacity of Drosophila melanogaster and shorten the life-span of Drosophila melanogaster.
authors.affiliation: Department of Preventive Medicine, Bengbu Medical College, Bengbu Anhui 233030, China. zwh3104@sina.com
authors.forename: Wenhong
authors.initials: W
authors.lastname: Zhao
authors.forename: Ding
authors.initials: D
authors.lastname: Zhang
authors.forename: Chunxian
authors.initials: C
authors.lastname: Zhou
authors.forename: Chengmei
authors.initials: C
authors.lastname: Jiang
mesh_terms: D017738:Alkanesulfonic Acids / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000502:physiology*; D005260:Female; D008017:Life Expectancy; D008136:Longevity; D008297:Male; D012098:Reproduction / Q000187:drug effects*; D013501:Surface-Active Agents / Q000494:pharmacology / Q000633:toxicity
chemical_list: D017738:Alkanesulfonic Acids; D013501:Surface-Active Agents; C030641:alkylbenzyl sulfonic acid