title: The efficacy of bromides, stiripentol and levetiracetam in two patients with malignant migrating partial seizures in infancy.
abstract: The syndrome of malignant migrating partial seizures in infancy is a devastating, age-specific, epileptic encephalopathy, which still presents an aetiological, pathophysiological and therapeutic problem. In this study, we present two patients who were diagnosed with the disease, based on electroclinical symptoms. The patients were treated with a combination of sodium bromide, stiripentol and levetiracetam. The first patient unequivocally responded, following a course of ineffective conventional drugs, and the second, who was diagnosed and treated immediately, showed a more significant therapeutic response. Antiepileptic drugs, previously reported to be beneficial in case reports, when given concomitantly, may substantially reduce the number and severity of seizures, without influence on psychomotor development. [Published with video sequences].
authors.affiliation: University of Belfrade, Mothers and Child Health Care Institute, Dr. Vukan Cupic, Belgrade, Serbia. m.djuric@ptt.rs
authors.forename: Milena
authors.initials: M
authors.lastname: Djuric
authors.forename: Ruzica
authors.initials: R
authors.lastname: Kravljanac
authors.forename: Gordana
authors.initials: G
authors.lastname: Kovacevic
authors.forename: Jelena
authors.initials: J
authors.lastname: Martic
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001965:Bromides / Q000627:therapeutic use*; D004148:Dioxolanes / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D000077287:Levetiracetam; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017670:Sodium Compounds / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D001965:Bromides; D004148:Dioxolanes; D017670:Sodium Compounds; D000077287:Levetiracetam; C027938:sodium bromide; C021092:stiripentol; D010889:Piracetam