title: Nuclear magnetic resonance analysis of protein-DNA interactions.
abstract: Recent methodological and instrumental advances in solution-state nuclear magnetic resonance have opened up the way to investigating challenging problems in structural biology such as large macromolecular complexes. This review focuses on the experimental strategies currently employed to solve structures of protein-DNA complexes and to analyse their dynamics. It highlights how these approaches can help in understanding detailed molecular mechanisms of target recognition.
authors.affiliation: Université de Toulouse, UPS, Department of Structural Biology and Biophysics, F-31077 Toulouse, France.
authors.forename: S
authors.initials: S
authors.lastname: Campagne
authors.forename: V
authors.initials: V
authors.lastname: Gervais
authors.forename: A
authors.initials: A
authors.lastname: Milon
mesh_terms: D004247:DNA / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: D004268:DNA-Binding Proteins; D004247:DNA