title: MicroRNAs and cardiovascular diseases.
abstract: MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Recent studies have demonstrated that miRNAs are aberrantly expressed in the cardiovascular system under some pathological conditions. Gain- and loss-of-function studies using in vitro and in vivo models have revealed distinct roles for specific miRNAs in cardiovascular development and physiological function. The implications of miRNAs in cardiovascular disease have recently been recognized, representing the most rapidly evolving research field. In the present minireview, the current relevant findings on the role of miRNAs in cardiac diseases are updated and the target genes of these miRNAs are summarized.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. kohono@kuhp.kyoto-u.ac.jp
authors.forename: Koh
authors.initials: K
authors.lastname: Ono
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: Jiahuai
authors.initials: J
authors.lastname: Han
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D006332:Cardiomegaly / Q000235:genetics / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000235:genetics*; D053487:DEAD-box RNA Helicases / Q000235:genetics; D005355:Fibrosis; D006321:Heart / Q000196:embryology; D006331:Heart Diseases / Q000378:metabolism; D006333:Heart Failure / Q000235:genetics; D006801:Humans; D024821:Metabolic Syndrome / Q000503:physiopathology; D051379:Mice; D035683:MicroRNAs / Q000502:physiology*; D009203:Myocardial Infarction / Q000235:genetics; D009206:Myocardium / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000502:physiology; D011506:Proteins / Q000235:genetics; D016601:RNA-Binding Proteins; D043244:Ribonuclease III / Q000235:genetics
chemical_list: C474044:Dgcr8 protein, mouse; C544547:MIRN1 microRNA, human; C548234:MIRN133 microRNA, human; D035683:MicroRNAs; D011506:Proteins; D016601:RNA-Binding Proteins; C509781:Dicer1 protein, mouse; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases