title: Comparison of success rate of nifedipine, progesterone, and bed rest for inhibiting uterine contraction in threatened preterm labor.
abstract: OBJECTIVE
  To compare the success rates and gestational ages at delivery of nifedipine, proluton depot administration as a tocolytic agent and bed rest groups to pregnant women with threatened preterm labor.
  
  
  METHODS
  A total of 150 pregnant women with threatened preterm labor between 28 and 35 weeks of gestation were enrolled in the study. All women underwent contraction inhibition randomly sorted into three groups. The first and second groups were inhibited with nifedipine and proluton depot, respectively. The third group was admitted for bed rest.
  
  
  RESULTS
  Nifedipine, proluton depot and bed rest can be used to inhibit contraction in threatened preterm labor. However, when time-to-event test was used, nifedipine took the shortest time for contraction inhibition with statistical significance.
  
  
  CONCLUSIONS
  Nifedipine, proluton depot and bed rest can be used successfully to inhibit contraction in threatened preterm labor. However, nifedipine took the shortest time to inhibit uterine contraction in threatened preterm labor.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. siscw@mahidol.ac.th
authors.forename: Saifon
authors.initials: S
authors.lastname: Chawanpaiboon
authors.forename: Kanjana
authors.initials: K
authors.lastname: Pimol
authors.forename: Ratre
authors.initials: R
authors.lastname: Sirisomboon
mesh_terms: D000077713:17 alpha-Hydroxyprogesterone Caproate; D000293:Adolescent; D000328:Adult; D001510:Bed Rest / Q000009:adverse effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D015149:Tocolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014590:Uterine Contraction / Q000187:drug effects; D055815:Young Adult
chemical_list: D003692:Delayed-Action Preparations; D006908:Hydroxyprogesterones; D045167:Progesterone Congeners; D015149:Tocolytic Agents; D000077713:17 alpha-Hydroxyprogesterone Caproate; D009543:Nifedipine