title: [A case of germ-cell tumor of the mediastinum].
abstract: An 18-year-old man complaining of chest pain was admitted to our hospital. Contrast-enhanced chest computed tomography (CT) showed an anterior mediastinal tumor with patchy enhanced lesions in the peripheral and poorly-enhanced central areas. His serum alpha fetoprotein (AFP) level was high. FDG-PET imaging indicated intense FDG uptake in the mediastinal tumor (SUVmax was 11.2), but no other abnormal FDG uptake, including in his testes, was detected. CT-guided needle biopsy revealed necrotizing tissue, including immature cartilage-like tissue. Based on these clinical features, we diagnosed mixed-type germ cell tumor originating from the mediastinum. Bleomycin, etoposide and cisplatin combination chemotherapy was administered every 3 weeks, for 4 cycles. His serum AFP level declined during the treatment course, and the mediastinal tumor decreased in size. After 4 cycles of chemotherapy, the residual tumor was resected completely and no viable cells were detected in the resected tumor. Tumor recurrence has not been detected for more than 9 months after surgery without adjuvant chemotherapy at the time of writing.
authors.affiliation: Department of Molecular and Internal Medicine, Graduate School of Biomedical Science, Hiroshima University.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Horimasu
authors.forename: Soichi
authors.initials: S
authors.lastname: Kitaguchi
authors.forename: Miki
authors.initials: M
authors.lastname: Ohe
authors.forename: Mihoko
authors.initials: M
authors.lastname: Doi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Maeda
authors.forename: Masao
authors.initials: M
authors.lastname: Doi
authors.forename: Masao
authors.initials: M
authors.lastname: Kuwabara
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy*; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin