title: Segmental dilatation of sigmoid colon in a neonate: atypical presentation and histology.
abstract: Segmental dilatation of the colon is a rare disorder of colonic motility in children, often presenting with severe constipation in older infants, children, and occasionally adults. It may mimic the commoner Hirschsprung disease clinicoradiologically but differs in that the ganglion cell morphology and distribution are typically normal in the colon. We report a neonate with segmental dilatation of the sigmoid colon who had an atypical clinical presentation and describe certain abnormalities in bowel histology (hypertrophied muscularis propria, nerve plexus, and ganglion cells located within the circular layer rather than the normal myenteric location), for the first time in the English literature.
authors.affiliation: Department of Paediatric Surgery, St. John's Medical College Hospital, St. John's National Academy of Health Sciences, Bangalore, India.
authors.forename: Shubha Attibele
authors.initials: SA
authors.lastname: Mahadevaiah
authors.forename: Poonam
authors.initials: P
authors.lastname: Panjwani
authors.forename: Usha
authors.initials: U
authors.lastname: Kini
authors.forename: Suravi
authors.initials: S
authors.lastname: Mohanty
authors.forename: Kanishka
authors.initials: K
authors.lastname: Das
mesh_terms: D000015:Abnormalities, Multiple; D012809:Colon, Sigmoid / Q000002:abnormalities* / Q000473:pathology / Q000601:surgery; D003248:Constipation / Q000209:etiology*; D003937:Diagnosis, Differential; D004108:Dilatation, Pathologic / Q000151:congenital / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D005145:Face / Q000002:abnormalities; D017809:Fatal Outcome; D005260:Female; D005725:Ganglia, Autonomic / Q000002:abnormalities; D006344:Heart Septal Defects, Atrial; D006627:Hirschsprung Disease / Q000175:diagnosis; D006801:Humans; D006984:Hypertrophy; D007231:Infant, Newborn; D007813:Laparotomy; D009130:Muscle, Smooth / Q000473:pathology; D009197:Myenteric Plexus / Q000002:abnormalities*; D013576:Syndactyly; D014034:Toes / Q000002:abnormalities