title: 5-HT and the immune system.
abstract: The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and adaptive immune cells. Furthermore, a recent paper describing the immune phenotype of 5-HT deficient mice is discussed.
authors.affiliation: Department of Pharmacology, Georgetown University, 3900 Reservoir Rd NW, Washington, DC 20007, United States. gpa3@georgetown.edu
authors.forename: Gerard P
authors.initials: GP
authors.lastname: Ahern
mesh_terms: D000818:Animals; D006801:Humans; D007107:Immune System / Q000276:immunology*; D011985:Receptors, Serotonin / Q000276:immunology*; D012701:Serotonin / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin