title: Sargachromanols as inhibitors of Na+/K+ ATPase and isocitrate lyase.
abstract: Sargachromanols A-P (1-16), 16 meroterpenoids of the chromene class isolated from the brown alga Sargassum siliquastrum, were evaluated for their inhibitory activities toward Na(+)/K(+) ATPase from porcine cerebral cortex and isocitrate lyase (ICL) from Candida albicans. These studies led to the identification of compounds 4, 6, 8, and 12 as potent Na(+)/K(+) ATPase inhibitors. Compounds 12, 13, and 16 exhibited moderate ICL inhibitory activity. Compound 12 also showed weak antibacterial activity. The preliminary structure-activity relationship of these compounds is described to elucidate the essential structural requirements.
authors.affiliation: Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-921, Republic of Korea.
authors.forename: Soon-Chun
authors.initials: SC
authors.lastname: Chung
authors.forename: Kyoung Hwa
authors.initials: KH
authors.lastname: Jang
authors.forename: Jiyoung
authors.initials: J
authors.lastname: Park
authors.forename: Chan-Hong
authors.initials: CH
authors.lastname: Ahn
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002176:Candida albicans / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013552:Swine
chemical_list: D001578:Benzopyrans; D004791:Enzyme Inhibitors; C503204:sargachromenol; D007522:Isocitrate Lyase; D000254:Sodium-Potassium-Exchanging ATPase