title: Scavenger receptor class B, type I: a promising immunotherapy target.
abstract: Scavenger receptor class B, type I (SR-BI) is a crucial molecule in lipid metabolism, since the interaction of high-density lipoproteins (HDLs) with SR-BI is involved in reverse cholesterol transport and cholesterol efflux. Recent findings also underscore a critical role of SR-BI in antimicrobial and immune responses. SR-BI is not only highly expressed in liver and steroidogenic glands, but also in endothelial cells, macrophages and dendritic cells. SR-BI mainly mediates anti-inflammatory responses, which may be altered by dysfunctional HDLs produced in several diseases. Moreover, SR-BI has been involved in the capture and cross-presentation of antigens from viruses, bacteria and parasites. It thus works as a pattern-recognition receptor that interacts with both damage-associated molecular patterns and pathogen-associated molecular patterns. These new findings in the microbiology and immunology fields present SR-BI as an unexplored therapeutic target that warrants further basic and applied research.
authors.affiliation: Division of Hepatology & Gene Therapy, University of Navarra, Pamplona, Navarra, Spain.
authors.forename: Jessica
authors.initials: J
authors.lastname: Fioravanti
authors.forename: José
authors.initials: J
authors.lastname: Medina-Echeverz
authors.forename: Pedro
authors.initials: P
authors.lastname: Berraondo
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001692:Biological Transport; D018955:CD36 Antigens / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D045142:Cross-Priming / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007167:Immunotherapy; D007249:Inflammation / Q000276:immunology*; D008075:Lipoproteins, HDL / Q000378:metabolism; D051379:Mice; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D018955:CD36 Antigens; D008075:Lipoproteins, HDL; D051193:Toll-Like Receptors; D002784:Cholesterol