title: Anti-inflammatory triterpenes from the leaves of Rosa laevigata.
abstract: Bioassay-guided fractionation of an EtOAc extract of the leaves of Rosa laevigata afforded two new 19-oxo-18,19-seco-ursane-type triterpenes (1 and 3), a new ursane-type nortriterpene (2), a new ursane-type triterpene lactone saponin (4), and two new oleanane-type triterpenoids (5 and 6), together with eight known triterpenoids (7-14). Compound 1, a 19-oxo-18,19-seco-28-norursane, possesses a conjugated diene between C-12 and C-17. Several of the isolated compounds (1, 5, 7, 11, and 13) exhibited moderate activities in anti-inflammatory assays in vitro.
authors.affiliation: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Zeng
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.forename: Ling-Zhi
authors.initials: LZ
authors.lastname: Li
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jiao
authors.forename: Pin-Yi
authors.initials: PY
authors.lastname: Gao
authors.forename: Shao-Jiang
authors.initials: SJ
authors.lastname: Song
authors.forename: Wan-Sheng
authors.initials: WS
authors.lastname: Chen
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008156:Luciferases / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D027826:Rosa / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; D008156:Luciferases