title: Beta-tricalcium phosphate/type I collagen cones with or without a barrier membrane in human extraction socket healing: clinical, histologic, histomorphometric, and immunohistochemical evaluation.
abstract: The aim of this study was to investigate the healing of human extraction sockets filled with β-tricalcium phosphate and type I collagen (β-TCP/Clg) cones with or without a barrier membrane. Twenty patients were divided in two groups: (A) β-TCP/Clg non-membrane and (B) β-TCP/Clg + barrier membrane. Clinical examination and biopsies from the grafted sites were collected 9 months later. Bone samples were analyzed using histomorphometry and immunohistochemistry. The horizontal dimension of the alveolar ridge was significantly reduced 9 months after socket preservation in the non-membrane group. There was bone formation with no significant differences between the two groups in the areas occupied by new bone (A = 42.4%; B = 45.3%), marrow (A = 42.7%; B = 35.7%), or residual graft (A = 9.7%; B = 12.5%). Immunohistochemistry revealed osteonectin expression in both groups. Both groups demonstrated sufficient amounts of vital bone and socket morphology to support dental implant placement after the 9-month healing period. A future trial to evaluate the alveolar outcomes at an earlier 6-month time point rather than the 9 months used in this study would be of interest.
authors.affiliation: Clinic of Oral Surgery, Faculty of Dentistry, University of Belgrade, Belgrade, Serbia.
authors.forename: Bozidar M B
authors.initials: BM
authors.lastname: Brkovic
authors.forename: Hari S
authors.initials: HS
authors.lastname: Prasad
authors.forename: Michael D
authors.initials: MD
authors.lastname: Rohrer
authors.forename: George
authors.initials: G
authors.lastname: Konandreas
authors.forename: George
authors.initials: G
authors.lastname: Agrogiannis
authors.forename: Dragana
authors.initials: D
authors.lastname: Antunovic
authors.forename: George K B
authors.initials: GK
authors.lastname: Sándor
mesh_terms: D000328:Adult; D000539:Alveolar Process / Q000473:pathology; D001706:Biopsy; D015519:Bone Density / Q000502:physiology; D001853:Bone Marrow / Q000473:pathology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002113:Calcification, Physiologic / Q000502:physiology; D002130:Calcium Phosphates / Q000627:therapeutic use*; D024042:Collagen Type I / Q000627:therapeutic use*; D004848:Epithelium / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010006:Osteoblasts / Q000473:pathology; D010011:Osteocytes / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D015676:Osteonectin / Q000032:analysis; D013524:Surgical Flaps; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D024042:Collagen Type I; D008567:Membranes, Artificial; D015676:Osteonectin; C485817:beta-tricalcium phosphate