title: Post-traumatic Infectious Endophthalmitis.
abstract: Post-traumatic endophthalmitis is an uncommon yet devastating complication of an open globe injury. Risk factors include presence of an intraocular foreign body (IOFB), lens rupture, delayed primary globe repair, rural trauma, and trauma with contaminated objects. Visual prognosis in post-traumatic endophthalmitis is affected by the virulence of the microbe, the presence of a retinal break or detachment, the timing of treatment, the presence or absence of an IOFB, and the extent of initial injury. Treatment should be started emergently with systemic and intravitreal antibiotics. In the setting of penetrating ocular trauma, antibiotic prophylaxis of endophthalmitis should be considered. The best treatment regimen has not been determined. The most frequent prophylactic regimens are: treatment with oral antibiotics, a short course of intravenous antibiotics followed by oral antibiotics, or intravitreal antibiotics plus oral antibiotics.
authors.affiliation: The Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, New Jersey, USA. bhagatne@umdnj.edu
authors.forename: Neelakshi
authors.initials: N
authors.lastname: Bhagat
authors.forename: Saya
authors.initials: S
authors.lastname: Nagori
authors.forename: Marco
authors.initials: M
authors.lastname: Zarbin
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005129:Eye Foreign Bodies / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D015807:Eye Injuries, Penetrating / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D058449:Intravitreal Injections; D012307:Risk Factors; D012421:Rupture
chemical_list: D000900:Anti-Bacterial Agents