title: [Comparative analysis of dimephosphon, ionol, and xydiphone effects on indomethacin-induced gastric lesions in rats].
abstract: Gastroprotective activity of dimephosphon, xydiphone, and ionol and their effects on the lipid peroxidation (LPO) indices and the activity of antioxidant enzymes in blood and organ tissues were studied on the model of indomethacin-induced gastric lesions in white rats. The indomethacin-induced gastropathy leads to increased concentration of LPO products in blood plasma and tissues. Dimephosphon and ionol reduced the number of gastric lesions and prevented LPO activation. In contrast, xydiphone administration had no effect on indometacin-induced gastric lesions and was accompanied by increased concentration of LPO products in the blood, liver, kidneys, spleen and stomachs of rats.
authors.forename: I Kh
authors.initials: IKh
authors.lastname: Valeeva
authors.forename: A F
authors.initials: AF
authors.lastname: Titarenko
authors.forename: L E
authors.initials: LE
authors.lastname: Ziganshina
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D012968:Etidronic Acid / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D051381:Rats; D013272:Stomach Diseases / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D050071:Bone Density Conservation Agents; D009943:Organophosphorus Compounds; C049638:dimephosphon; D002084:Butylated Hydroxytoluene; D012968:Etidronic Acid; D007213:Indomethacin