title: Therapeutic strategies for advanced neuroendocrine carcinomas of jejunum/ileum and pancreatic origin.
abstract: Multimodal treatment options for advanced gastroenteropancreatic neuroendocrine tumours (NET) of jejunum/ileum and of pancreatic origin are reviewed. Current topics being discussed are: European Neuroendocrine Tumour Society 2006/7, American Joint Cancer Committee/Union Internationale Contre le Cancer 2009 and WHO 2010 recommendations for grading and staging of NET; surgery of the primary tumour in distant metastasised disease; surgery of metastatic liver disease and impact on survival; somatostatin analogues for symptom control and for tumour control; selective internal radiation therapy with 90Y-microspheres as novel local ablative therapy in liver metastases; peptide receptor radionuclide therapy; novel chemotherapy regimens (eg, temozolomide) and novel targeted therapies (eg, sunitinib and everolimus).
authors.affiliation: Department of Internal Medicine II, University-Hospital Campus Grosshadern, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System (GEPNET-KUM), Ludwig-Maximilians-University of Munich, Munich 81377, Germany. christoph.auernhammer@med.uni-muenchen.de
authors.forename: Christoph J
authors.initials: CJ
authors.lastname: Auernhammer
authors.forename: Burkhard
authors.initials: B
authors.lastname: Göke
mesh_terms: D017115:Catheter Ablation / Q000379:methods; D004067:Digestive System Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology / Q000628:therapy; D007580:Jejunal Neoplasms / Q000473:pathology / Q000628:therapy; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary / Q000628:therapy; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy; D011379:Prognosis