title: Detection of adulteration in acetonitrile.
abstract: To address the increasing concern that acetonitrile may be intentionally adulterated to meet the shortfall in global supplies resulting from a downturn in its manufacturing, three analytical techniques were examined in this study. Gas Chromatography with Thermal Conductivity Detection (GC-TCD), Near Infrared (NIR) spectroscopy and Fourier Transform Infrared (FT-IR) spectroscopy were assessed for their ability to detect and quantify potential adulterants including water, alternative organic solvents, and by-products associated with the production of acetonitrile. The results of the assessment of the three techniques for acetonitrile adulteration testing are discussed.
authors.affiliation: Process & Product Development, Amgen Inc., 1 Amgen Center Dr, Thousand Oaks, CA 91320, USA.
authors.forename: Guoxiang
authors.initials: G
authors.lastname: Chen
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fujimori
authors.forename: Hans
authors.initials: H
authors.lastname: Lee
authors.forename: Yasser
authors.initials: Y
authors.lastname: Nashed-Samuel
authors.forename: Joseph
authors.initials: J
authors.lastname: Phillips
authors.forename: Gary
authors.initials: G
authors.lastname: Rogers
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.forename: Chanel
authors.initials: C
authors.lastname: Yee
mesh_terms: D000097:Acetonitriles / Q000032:analysis / Q000737:chemistry*; D002138:Calibration; D002849:Chromatography, Gas; D004340:Drug Contamination; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D019265:Spectroscopy, Near-Infrared; D013814:Thermal Conductivity; D013997:Time Factors
chemical_list: D000097:Acetonitriles; D012997:Solvents; C032159:acetonitrile