title: Boron neutron capture therapy for clear cell sarcoma (CCS): biodistribution study of p-borono-L-phenylalanine in CCS-bearing animal models.
abstract: Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of (10)B (45-74 ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of L-BPA-fructose complex (500 mg BPA/kg).
authors.affiliation: Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Andoh
authors.forename: T
authors.initials: T
authors.lastname: Fujimoto
authors.forename: T
authors.initials: T
authors.lastname: Sudo
authors.forename: I
authors.initials: I
authors.lastname: Fujita
authors.forename: M
authors.initials: M
authors.lastname: Imabori
authors.forename: H
authors.initials: H
authors.lastname: Moritake
authors.forename: T
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Sakuma
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Kawabata
authors.forename: M
authors.initials: M
authors.lastname: Kirihata
authors.forename: T
authors.initials: T
authors.lastname: Akisue
authors.forename: K
authors.initials: K
authors.lastname: Yayama
authors.forename: M
authors.initials: M
authors.lastname: Kurosaka
authors.forename: S
authors.initials: S
authors.lastname: Miyatake
authors.forename: Y
authors.initials: Y
authors.lastname: Fukumori
authors.forename: H
authors.initials: H
authors.lastname: Ichikawa
mesh_terms: D000293:Adolescent; D000818:Animals; D001896:Boron Compounds / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D018227:Sarcoma, Clear Cell / Q000378:metabolism / Q000532:radiotherapy*; D014018:Tissue Distribution
chemical_list: D001896:Boron Compounds; D010649:Phenylalanine; C033685:4-boronophenylalanine