title: A cytohistological study of Ki-67 expression in ovarian tumors.
abstract: OBJECTIVE
  The study was conducted to evaluate the diagnostic accuracy of imprint cytology in ovarian neoplasms, and to investigate the biological significance of Ki-67 antigen expression in benign and malignant ovarian tumors and correlate it with histological type, grade, and stage of malignant tumor.
  
  
  METHODS
  A total of 50 cases including 25 prospective and 25 retrospective cases were studied. Imprint cytology was performed on 25 ovarian tumors and compared with histopathological diagnosis. Ki-67 immunohistochemistry was performed on all 50 cases.
  
  
  RESULTS
  On immunohistochemistry, benign tumors had a mean Ki-67 index of 3.2 ± 3.7 while malignant tumors had a mean Ki-67 index of 33.1 ± 16.7, the difference being statistically significant. Significant correlation was observed between the Ki-67 index and stage of the tumor; however, there was no correlation between the grade of differentiation and histological type of tumor with the Ki-67 index.
  
  
  CONCLUSIONS
  In the present study, the Ki-67 index was higher in advanced stage tumors; hence a higher Ki-67 index points toward the aggressive behavior and poorer clinical outcomes.
authors.affiliation: Department of Pathology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India.
authors.forename: Monisha
authors.initials: M
authors.lastname: Choudhury
authors.forename: Seema
authors.initials: S
authors.lastname: Goyal
authors.forename: Mukta
authors.initials: M
authors.lastname: Pujani
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis* / Q000235:genetics; D008853:Microscopy; D010051:Ovarian Neoplasms / Q000473:pathology*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D019394:Ki-67 Antigen