title: Equine-derived bone substitutes in orthopedics and traumatology: authors' experience.
abstract: OBJECTIVE
  To evaluate the use of equine-derived bone grafts in the treatment of bone loss in a heterogeneous clinical case series.
  
  
  METHODS
  The study population was 48 patients (29 males and 19 females; mean age, 49 years; range, 9-84); the orthopedic defect site was located on the right side in 22 and on the left side in 26 cases. The graft material was antigen-free equine-derived collagen bone cleaned with an enzymatic treatment.
  
  
  RESULTS
  Clinical and radiographic healing times were virtually similar; graft osseointegration needed from two to three months longer to heal.
  
  
  CONCLUSIONS
  The outcome after grafting with an equine-derived bone substitute was satisfactory. Further study is needed to demonstrate its statistically significant effectiveness in the treatment of orthopedic defects like those in this series.
authors.affiliation: Unit of Orthopedics and Traumatology, "San Bortolo" Hospital, Vicenza, Italy. santinivicenza@libero.it
authors.forename: S
authors.initials: S
authors.lastname: Santini
authors.forename: P
authors.initials: P
authors.lastname: Barbera
authors.forename: M
authors.initials: M
authors.lastname: Modena
authors.forename: R
authors.initials: R
authors.lastname: Schiavon
authors.forename: M
authors.initials: M
authors.lastname: Bonato
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation; D002648:Child; D005260:Female; D005593:Fracture Fixation, Internal / Q000379:methods*; D006736:Horses; D006801:Humans; D008297:Male; D008875:Middle Aged; D009985:Orthopedics / Q000379:methods*; D016348:Osseointegration; D012189:Retrospective Studies; D014183:Transplantation, Heterologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018786:Bone Substitutes