title: Formal synthesis of cortistatins.
abstract: A unified strategy toward the asymmetric facile construction of the [6.7.6.5]oxapentacyclic skeleton of cortistatins is reported, featuring intramolecular Diels-Alder (IMDA), oxidative dearomatization, and an oxy-Michael addition reaction.
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.
authors.forename: Lichao
authors.initials: L
authors.lastname: Fang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
authors.forename: Lianzhu
authors.initials: L
authors.lastname: Liu
authors.forename: Junmin
authors.initials: J
authors.lastname: Quan
authors.forename: Chuang-chuang
authors.initials: CC
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000517:prevention & control; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009479:Neuropeptides / Q000138:chemical synthesis* / Q000627:therapeutic use; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism; D013256:Steroids / Q000138:chemical synthesis* / Q000627:therapeutic use
chemical_list: D020533:Angiogenesis Inhibitors; D009479:Neuropeptides; D013256:Steroids; C099323:cortistatin