title: Plasma glucose after stomach or jejunum glucose infusion in Roux-en-Y gastric bypass patients--a possible implication for early satiety mechanism.
abstract: BACKGROUND
  Morbidly obese patients undergoing gastric bypass surgery experience early satiety soon after the surgery; the mechanism of this effect is poorly understood. As blood glucose concentration plays a role in appetite regulation in humans, we hypothesized that after gastric bypass surgery glucose absorbed mainly in jejunum leads to a greater rise in plasma glucose that if it is ingested in stomach.
  
  
  METHODS
  24 non-diabetes morbidly obese patients (15 women, 9 men, mean age [± SD] 35.6 ± 11.9 years, body weight 140.7 ± 33.1 kg, BMI 46.8 ± 8.3 kg/m²) undergoing Roux-en-Y gastric bypass surgery were given 10 ml of 40% glucose solution to the stomach before its size reduction and to the jejunum after gastro-jejunal anastomosis was formed.
  
  
  RESULTS
  After jejunal infusion blood glucose increased more rapidly and was ∼30% higher than after stomach infusion. Moreover, this increase was less pronounced in more obese patients.
  
  
  CONCLUSIONS
  In patients after Roux-en-Y gastric bypass surgery glucose absorbed in jejunum leads to greater rise in plasma glucose concentration than if it is ingested in stomach. This phenomenon may help explain satiety feeling occurring early in gastric bypass surgery patients.
authors.affiliation: Department of Internal Medicine and Diabetology, Barlicki University Hospital No 1, Medical University of Lodz, Lodz, Poland. bigosik@poczta.onet.pl
authors.forename: L
authors.initials: L
authors.lastname: Czupryniak
authors.forename: M
authors.initials: M
authors.lastname: Pawłowski
authors.forename: D
authors.initials: D
authors.lastname: Szymański
authors.forename: W
authors.initials: W
authors.lastname: Olejniczak
authors.forename: M
authors.initials: M
authors.lastname: Saryusz-Wolska
authors.forename: J
authors.initials: J
authors.lastname: Loba
authors.forename: J
authors.initials: J
authors.lastname: Strzelczyk
mesh_terms: D000328:Adult; D005260:Female; D015390:Gastric Bypass; D005947:Glucose / Q000008:administration & dosage* / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008297:Male; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery*; D012528:Satiety Response / Q000502:physiology*
chemical_list: D005947:Glucose