title: [Antigenic differences in wild-type and guinea pig-adapted Ebola virus strains].
abstract: The splenocytes isolated from the mice immunized with wild-type or guinea pig-adapted Ebola virus strains were used to obtain hybridoma collections. Investigation of the monoclonal antibodies (mAb) obtained to one of the strains to another revealed antigenic interstrain differences in nucleoprotein and VP40. It is interesting that the differences were found in the hydridoma collection obtained against the wild-type strain. The mAbs produced by hydridomas to the adapted strain were found to equally well the antigens of both strains.
authors.forename: I A
authors.initials: IA
authors.lastname: Razumov
authors.forename: E I
authors.initials: EI
authors.lastname: Kazachinskaia
authors.forename: A A
authors.initials: AA
authors.lastname: Chepurnov
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000918:Antibody Specificity; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000276:immunology*; D015153:Blotting, Western; D002522:Chlorocebus aethiops; D029043:Ebolavirus / Q000276:immunology*; D016563:Filoviridae / Q000276:immunology; D006168:Guinea Pigs; D006825:Hybridomas; D051379:Mice; D013045:Species Specificity; D014709:Vero Cells; D014763:Viral Matrix Proteins / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; C080981:VP40 protein, virus; D014763:Viral Matrix Proteins