title: Atypical metastatic carcinoid of the uterine cervix and review of the literature.
abstract: Atypical carcinoid tumors of the uterine cervix represent rare neuroendocrine tumors and are highly aggressive, showing early lymphatic invasion and hematogenous distant metastases. Because of the small number of cases, there are currently no recommendations regarding treatment, and little is known about the response to chemotherapeutic agents. A 39-year-old woman was diagnosed with a primary atypical carcinoid of the uterine cervix with numerous metastases to the liver. After radical hysterectomy, she underwent hepatic arterial chemoembolization with streptozotocin and 5-fluorouracil. Complete response was achieved in numerous liver metastases. At the 2-year follow up of chemotherapy, the patient remains alive. Treatment for atypical carcinoid tumors remains elusive, however hepatic arterial chemoembolization with streptozotocin and 5-fluorouracil was effective in the present primary atypical carcinoid with liver metastases. A review of the previous reports is also presented.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. yyoshida@u-fukui.ac.jp
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Kumiko
authors.initials: K
authors.lastname: Sato
authors.forename: Kanji
authors.initials: K
authors.lastname: Katayama
authors.forename: Akio
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Imamura
authors.forename: Fumikazu
authors.initials: F
authors.lastname: Kotsuji
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D002276:Carcinoid Tumor / Q000473:pathology / Q000556:secondary* / Q000601:surgery / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007044:Hysterectomy; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary / Q000628:therapy; D013311:Streptozocin / Q000008:administration & dosage / Q000627:therapeutic use; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D013311:Streptozocin; D005472:Fluorouracil