title: A decline in renal function is associated with loss of bone mass in Korean postmenopausal women with mild renal dysfunction.
abstract: This study was conducted to assess the relationship between estimated glomerular filtration rate (eGFR) and bone mineral density (BMD) in Korean postmenopausal women with mild renal dysfunction. A total of 328 postmenopausal women who underwent BMD measurement during health check-up was investigated. BMD was measured in lumbar spine (L1-L4), femoral neck, total proximal femur and femoral trochanteric areas by dual energy radiography absorptiometry and renal function was estimated by eGFR using Cockcroft-Gault equation. Of the 328 subjects, 317 (96.6%) had an eGFR ≥60 mL/min/1.73 m(2). By using simple linear regression analysis, age, height, weight and eGFR were significantly associated with BMD for the 4 aforementioned anatomic sites, while serum levels of creatinine and blood urea nitrogen did not influence BMD. When multiple regression analyses were applied, age and body weight still had significant associations with BMD at 4 different anatomic sites (P < 0.001). A significant association of eGFR with BMD remained in the lumbar spine, femoral neck and proximal total femur (P < 0.05) but not in the trochanteric area (P = 0.300). Our study suggests that a decline of renal function is associated with lower BMD in the lumbar spine, femoral neck and total proximal femur areas in Korean menopausal women with mild renal dysfunction.
authors.affiliation: Armed Forces Seoul Hospital, Seoul, Korea.
authors.forename: Hack-Lyoung
authors.initials: HL
authors.lastname: Kim
authors.forename: In Young
authors.initials: IY
authors.lastname: Park
authors.forename: Jin Man
authors.initials: JM
authors.lastname: Choi
authors.forename: Se-Min
authors.initials: SM
authors.lastname: Hwang
authors.forename: Hyo Sang
authors.initials: HS
authors.lastname: Kim
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Lim
authors.forename: Min
authors.initials: M
authors.lastname: Kim
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Son
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D001806:Blood Urea Nitrogen; D015519:Bone Density; D003404:Creatinine / Q000097:blood; D005260:Female; D005272:Femur Neck / Q000502:physiology; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D007677:Kidney Function Tests; D008159:Lumbar Vertebrae / Q000502:physiology; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D056910:Republic of Korea
chemical_list: D003404:Creatinine