title: Colon cancer arising in an ulcer scar due to intestinal Behçet's disease.
abstract: Neoplasms rarely arise in the intestinal lesion of Behçet's disease. We present a 77-year-old man with Behçet's disease who developed colon cancer in the ileocecal region. Ileocecal resection was performed and pathological examination of the specimen revealed advanced colon carcinoma (pT3, N1, M0). The lesion was associated with destroyed tunica muscularis and severe fibrosis suggesting a transmural ulcer scar (Ul-IVs). The p53 gene mutation analysis of the tumor showed a heterozygous deletion. This case indicates there is a possibility that cancer may develop in intestinal lesions of patients with Behçet's disease as well as in those with other inflammatory bowel diseases.
authors.affiliation: Department of Gastroenterology, Kanazawa Medical University, Japan. m-yamada@kanazawa-med.ac.jp
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yamada
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Shiroeda
authors.forename: Tomoe
authors.initials: T
authors.lastname: Nomura
authors.forename: Ranji
authors.initials: R
authors.lastname: Hayashi
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Sato
authors.forename: Mikihiro
authors.initials: M
authors.lastname: Tsutsumi
authors.forename: Tomiyasu
authors.initials: T
authors.lastname: Arisawa
mesh_terms: D000368:Aged; D001483:Base Sequence; D001528:Behcet Syndrome / Q000150:complications* / Q000473:pathology; D002921:Cicatrix / Q000150:complications / Q000473:pathology; D018389:Codon, Nonsense; D003110:Colonic Neoplasms / Q000150:complications* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics; D016158:Genes, p53; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications* / Q000473:pathology; D008297:Male; D017384:Sequence Deletion; D014456:Ulcer / Q000150:complications* / Q000473:pathology
chemical_list: D018389:Codon, Nonsense; D004273:DNA, Neoplasm