title: Differences in hepatic gene expression as a major distinguishing factor between Korean native pig and Yorkshire.
abstract: There are phenotypic differences between Korean native pig (KNP) and Yorkshire (YS) breeds due to different interests in selection. YS has been selected for industrial interests such as a growth rate and lean meat production, while KNP has been maintained as a regional breed with local interests such as disease resistance and fat content in and between muscle. A comparison of gene expression profiles from liver tissue reflected overall long-term effects of artificial selection for these two pig breeds. Based on minimum positive false discovery rate (less than 10%) and fold change (|FC|>1.5), 73 differentially expressed genes (DEGs) were identified. Functional analysis of these DEGs indicated clear distinctions in signaling capacity related to epidermal growth factor (EGF), extracellular structure, protein metabolism, and detoxification. Hepatic DEGs demonstrated the importance of hormonal and metabolic capabilities to differences between these two pig breeds.
authors.affiliation: College of Life Sciences and Biotechnology, Korea University, Seoul, Korea.
authors.forename: Seung-Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: So-Ra
authors.initials: SR
authors.lastname: Kim
authors.forename: Jung-Rok
authors.initials: JR
authors.lastname: Kim
authors.forename: Jin-Kyoo
authors.initials: JK
authors.lastname: Moon
authors.forename: Bong-Hwan
authors.initials: BH
authors.lastname: Choi
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Kwan-Suk
authors.initials: KS
authors.lastname: Kim
authors.forename: Tae-Hun
authors.initials: TH
authors.lastname: Kim
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Cheol-Koo
authors.initials: CK
authors.lastname: Lee
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D050218:Body Fat Distribution; D001947:Breeding; D055028:Comparative Genomic Hybridization; D004815:Epidermal Growth Factor / Q000235:genetics / Q000378:metabolism; D005060:Europe; D020869:Gene Expression Profiling; D006801:Humans; D007723:Korea; D008099:Liver / Q000378:metabolism*; D008460:Meat; D018482:Muscle, Skeletal / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010802:Phylogeny; D012333:RNA, Messenger / Q000032:analysis*; D013045:Species Specificity; D034421:Sus scrofa / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; D012333:RNA, Messenger; D004815:Epidermal Growth Factor