title: Exercise training and antioxidants: effects on rat heart tissue exposed to lead acetate.
abstract: We have investigated the cardioprotective effects of exercise training and/or curcumin on lead acetate-induced myocardial damage. Forty rats were randomly divided into 5 groups: (1) lead acetate, (2) curcumin, (3) endurance training, (4) training + curcumin, (5) sham groups. The rats in groups 3 and 4 experienced the treadmill running of 15 to 22 m/min for 25 to 64 minutes, 5 times a week for 8 weeks. Groups 1 to 4 received lead acetate (20 mg/kg), the sham group received curcumin solvent (ethyl oleat), and the curcumin and training + curcumin groups received curcumin solution (30 mg/kg) intraperitoneally. Lead administration resulted in significant increases in high-sensitivity C-reactive protein (hs-CRP), creatine kinase-MB (CK-MB), malondialdehyde (MDA), and low-density lipoprotein (LDL), and significantly decreased glutathione peroxidase (GPx), Total Antioxidant Capacity (TAC), and high-density lipoprotein (HDL) levels. Treadmill running and\or curcumin supplementation resulted in a significant decrease in hs-CRP, CK-MB, MDA, and LDL levels and significantly increased GPx, TAC, and HDL levels. These results suggest a lifestyle-induced cardioprotective potential in ameliorating lead-induced cardiotoxicity.
authors.affiliation: Faculty of Physical Education and Sport Sciences, Department of Exercise Physiology, University of Mazandaran, Babolsar, Iran. vdabidiroshan@yahoo.com
authors.forename: Valiollah Dabidi
authors.initials: VD
authors.lastname: Roshan
authors.forename: Mohammad
authors.initials: M
authors.lastname: Assali
authors.forename: Akbar Hajizadeh
authors.initials: AH
authors.lastname: Moghaddam
authors.forename: Mahdi
authors.initials: M
authors.lastname: Hosseinzadeh
authors.forename: Jonathan
authors.initials: J
authors.lastname: Myers
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000032:analysis; D008078:Cholesterol, LDL / Q000032:analysis / Q000378:metabolism; D052279:Creatine Kinase, MB Form / Q000032:analysis / Q000378:metabolism; D003474:Curcumin / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000032:analysis / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008019:Life Style; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000378:metabolism; D009206:Myocardium / Q000473:pathology; D009942:Organometallic Compounds / Q000633:toxicity*; D018384:Oxidative Stress; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D002316:Cardiotonic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D009942:Organometallic Compounds; D008315:Malondialdehyde; D002097:C-Reactive Protein; D005979:Glutathione Peroxidase; D052279:Creatine Kinase, MB Form; D003474:Curcumin; C008261:lead acetate