title: [Signet ring cell carcinoma of the ampulla of Vater].
abstract: BACKGROUND
  Signet ring cell carcinoma of the ampulla of Vater is a rare entity and less than 20 cases have been described in the literature. We report the cases of two patients with this disease and provide a literature review of previous studies.
  
  
  METHODS
  We describe two patients with obstructive jaundice. Abdominal ultrasonography and abdominal computed tomography showed dilatation of the intrahepatic and common bile duct. Duodenoscopy indicated a protruding mass on the ampulla of Vater. Histopathological examination showed round cells and their nuclei were located on one side with prominent signet-ring features. One patient underwent a cephalic pancreatoduodenectomy with lymphadenectomy and the other a total pancreatectomy.
  
  
  CONCLUSIONS
  Signet ring cell carcinoma of the ampulla of Vater has only been described in isolated cases in the literature. Therefore, the clinicopathological features and prognosis of this disease have not yet been well defined.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Universitario La Paz, Madrid, España. burgos.aurora@gmail.com
authors.forename: Aurora Burgos
authors.initials: AB
authors.lastname: García
authors.forename: Eduardo Martín
authors.initials: EM
authors.lastname: Arranz
authors.forename: Rafael Rey
authors.initials: RR
authors.lastname: Sanz
authors.forename: Eva Marín
authors.initials: EM
authors.lastname: Serrano
authors.forename: María Dolores Martín
authors.initials: MD
authors.lastname: Arranz
authors.forename: Paloma González
authors.initials: PG
authors.lastname: Sanz-Agero
authors.forename: Elena Collantes
authors.initials: EC
authors.lastname: Bellido
authors.forename: José Juan Pozo
authors.initials: JJ
authors.lastname: Kreilinger
authors.forename: Luis Asensio
authors.initials: LA
authors.lastname: Prianes
authors.forename: Luis Alberto Mata
authors.initials: LA
authors.lastname: Juberías
authors.forename: Juan Pedro Pérez
authors.initials: JP
authors.lastname: Robledo
authors.forename: José Manuel Suárez
authors.initials: JM
authors.lastname: Parga
authors.forename: José María Segura
authors.initials: JM
authors.lastname: Cabral
mesh_terms: D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology* / Q000601:surgery; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D018279:Carcinoma, Signet Ring Cell / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003131:Combined Modality Therapy; D003138:Common Bile Duct Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology; D007583:Jejunum / Q000601:surgery; D008099:Liver / Q000601:surgery; D008224:Lymphoma, Follicular; D008297:Male; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary; D010180:Pancreatectomy; D016577:Pancreaticoduodenectomy; D013156:Splenectomy; D001749:Urinary Bladder Neoplasms; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine