title: Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women.
abstract: The aim of the present study was to investigate the association of PLIN1 11482G>A (rs894160) and PLIN1 13041A>G (rs2304795) polymorphisms with body composition, energy and substrate metabolism, and the metabolic response to a 12-week energy-restricted diet in obese women. The study comprised a total of seventy-eight obese (BMI 34·0 (SD 2·8) kg/m(2)) women (age 36·7 (SD 7) years). We measured weight, height and waist circumference before and after a 12-week controlled energy-restricted diet intervention. Body fat mass and lean mass were measured by dual-energy X-ray absorptiometry. RMR and lipid oxidation rate were measured by indirect calorimetry. We also analysed fasting plasma glucose, insulin, cholesterol and leptin. Women carrying the 11482A allele had a lower reduction in waist circumference than non-A allele carriers (3·2 (SD 0·5) v. 4·6 (SD 0·6) %, respectively, P = 0·047; P for gene-diet interaction = 0·064). Moreover, women with the 11482A allele had a higher decrease in lipid oxidation rate than non-A allele carriers (58·9 (SD 6·7) v. 31·3 (SD 8·2) %, respectively, P = 0·012; P for gene-diet interaction = 0·004). There was no interaction effect between the 13041A>G polymorphism and diet-induced changes on the outcome variables (all P>0·1). These results confirm and extend previous findings suggesting that the PLIN1 11482G>A polymorphism plays a modulating role on diet-induced changes in body fat and energy metabolism in obese women.
authors.affiliation: Department of Physical Education and Sport, School of Physical Activity and Sport Sciences, University of Granada, Granada, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Ruiz
authors.forename: E
authors.initials: E
authors.lastname: Larrarte
authors.forename: J
authors.initials: J
authors.lastname: Margareto
authors.forename: R
authors.initials: R
authors.lastname: Ares
authors.forename: P
authors.initials: P
authors.lastname: Alkorta
authors.forename: I
authors.initials: I
authors.lastname: Labayen
mesh_terms: D000328:Adult; D000483:Alleles; D001481:Basal Metabolism; D001823:Body Composition; D015992:Body Mass Index; D002352:Carrier Proteins; D004038:Diet, Reducing; D004734:Energy Metabolism; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D050356:Lipid Metabolism; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy* / Q000235:genetics* / Q000378:metabolism; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013030:Spain; D055105:Waist Circumference; D015431:Weight Loss; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; C000602978:PLIN1 protein, human; D000070778:Perilipin-1; D010750:Phosphoproteins