title: Effect of platelet rich plasma gel in a physiologically relevant platelet concentration on wounds in persons with spinal cord injury.
abstract: The objective of the study was to investigate the use of a 1·3 times normal platelet concentration platelet-rich plasma (PRP) gel to move chronic wounds towards healing in persons with spinal cord injury (SCI). The study design was a case series of 20 persons with SCI with non healing wounds. The outcome measures were, in wound area, volume, undermining and sinus tracts/tunnels (ST/Ts), calculated average, (i) percent of change from baseline, (ii) change per day from baseline, (iii) number of treatments and (iv) number of weeks. In a mean of 4·0, after treatments over 3·4 weeks, the wounds closed on an average of 47·9% in area and 56·0% in volume. Undermining closed on an average of 31·4% using 3·5 treatments over 2·6 weeks. ST/Ts closed on an average of 26·1% after 2·3 treatments over 1·5 weeks. Clinical relevance by percent of positive responders and their response: in area, 90·0% of the subjects responded positively, the average reduction was 53·8%. In volume, 90·0% responded, with an average reduction of 67·3%. Of four subjects with undermining, 75% closed 47·0% on average. Of the three with ST/Ts, 100% closed 26·1% on average. Average haemoglobin and haematocrit levels were below normal. To conclude, 1·3× PRP gel appears to progress chronic, non healing wounds in SCI patients into the granulation phase of healing quickly. Review of the literature shows these results may not be applied to all PRP preparations.
authors.affiliation: lrappl@cytomedix.com
authors.forename: Laurie M
authors.initials: LM
authors.lastname: Rappl
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D008875:Middle Aged; D010976:Platelet Count; D053657:Platelet-Rich Plasma; D012189:Retrospective Studies; D012867:Skin / Q000293:injuries* / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
chemical_list: D005782:Gels