title: [Pathogenesis, treatment, and prevention of erosive-ulcerative lesions in the mucous membrane of the upper digestive tract].
abstract: The authors present results of examination and treatment of 698 patients with erosive-ulcerative lesions in the mucous membrane of the upper digestive tract that accounted for 39.49% of all subjects with gastrointestinal hemorrhage. These lesions were diagnosed in 73.8% of the patients in critical conditions. The leading role in their pathogenesis is played by ischemic-perfusion syndrome, gastric acid hypersecretion resulting in microcirculatory disorders, hypoxia, and activation of free radicals in gastric and duodenal mucosa. It is concluded that preventive and conservative therapy of the above lesions must be focused on the correction of ischemia and after-effects of reperfusion to achieve long-standing hypoacidic state (pH < 4) with the help of up-to-date antisecretory agents.
authors.forename: V M
authors.initials: VM
authors.lastname: Timerbulatov
authors.forename: I M
authors.initials: IM
authors.lastname: Urazbakhtin
authors.forename: Sh V
authors.initials: ShV
authors.lastname: Timerbulatov
authors.forename: R B
authors.initials: RB
authors.lastname: Sagitov
authors.forename: V M
authors.initials: VM
authors.lastname: Sibaev
mesh_terms: D000126:Achlorhydria / Q000139:chemically induced; D000818:Animals; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism; D006489:Hemostatic Techniques; D006635:Histamine H2 Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D023421:Models, Animal; D009092:Mucous Membrane / Q000378:metabolism / Q000503:physiopathology; D010437:Peptic Ulcer / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D054328:Proton Pump Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D015427:Reperfusion Injury / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D012307:Risk Factors; D016896:Treatment Outcome; D041742:Upper Gastrointestinal Tract / Q000378:metabolism / Q000503:physiopathology
chemical_list: D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors