title: Hypocalcaemia due to hypoparathyroidism in β-thalassemia major. A study of a new case.
abstract: OBJECTIVE
  To report a new case of hypoparathyroidism in a child with ß-thalassemia major
  
  
  METHODS
  We report a case of a 17-year-old Tunisian girl with transfusion-dependent thalassemia major presented with paresthesia and pubertal delay. Laboratory investigations showed hypocalcaemia and hyperphosphatemia. Parathyroid hormone level was low (2 ng/l, normal range: 12-72 ng/l) than expected for the degree of hypocalcaemia. Serum ferritin concentration was 1770ng/ml. The patient was started on oral daily calcium supplementation, Alfa calciferol and intensive iron chelation therapy. Follow-up after 6 and 12 months revealed normal Calcium and ECG showed QT interval within normal range.
  
  
  CONCLUSIONS
  Investigating calcium homeostasis at regular intervals and early management of any abnormality can preclude the occurrence of complications.
authors.affiliation: Centre National de Greffe de Moelle Osseuse, Tunis.
authors.forename: Nawel
authors.initials: N
authors.lastname: Dhouib
authors.forename: Zinet
authors.initials: Z
authors.lastname: Turki
authors.forename: Fethi
authors.initials: F
authors.lastname: Mellouli
authors.forename: Monia
authors.initials: M
authors.lastname: Ouederni
authors.forename: Salem
authors.initials: S
authors.lastname: Yahiaoui
authors.forename: Sonia
authors.initials: S
authors.lastname: Nagi
authors.forename: Ridha
authors.initials: R
authors.lastname: Kouki
authors.forename: Claude
authors.initials: C
authors.lastname: Ben Slama
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bejaoui
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology*; D007011:Hypoparathyroidism / Q000150:complications*; D017086:beta-Thalassemia / Q000150:complications*