title: [Effects of packaging forms on the stability of vitamin B1 and vitamin C in TPN admixtures].
abstract: In order to reduce a microbial contamination and needle stick injuries that are associated with a mixing procedure in home parentera nutrition(HPN), nutrition(TPN)solution bags pre-mixed with trace elements may be provided in a form of outer packaging. On the other hand, a packaging form used to enclose the TPN bag after admixture may significantly affect the stability of vitamins. With a focus on possible decrease in vitamin B1 and C content, we investigated the effects of the packaging form. As a result, the TPN bag, which is packed in a light-resistant outer wrap of oxygen-barrier film with an oxygen absorbent under reduced pressure, suppressed a decrease in vitamin content most. However, the decrease in vitamin C content was observed when there was a long time-lag between a preparation and a packaging. We thought it was desirable to pack the TPN bag promptly after the preparation.
authors.affiliation: Information Center for Infusion Therapy and Product, Otsuka Pharmaceutical Factory, Inc.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hashimoto
authors.forename: Ryosei
authors.initials: R
authors.lastname: Iwahara
authors.forename: Hideki
authors.initials: H
authors.lastname: Sato
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis*; D004349:Drug Packaging; D004355:Drug Stability; D016562:Parenteral Nutrition, Home Total; D019999:Pharmaceutical Solutions; D013831:Thiamine / Q000032:analysis*; D013997:Time Factors
chemical_list: D019999:Pharmaceutical Solutions; D001205:Ascorbic Acid; D013831:Thiamine