title: Macrophages and neutrophils cooperate in immune responses to Leishmania infection.
abstract: Neutrophils and macrophages are phagocytic cells that cooperate during inflammation and tissue repair. Neutrophils undergo apoptosis and are engulfed by macrophages. Engulfment modulates macrophage activation and microbicidal activity. Infection by Leishmania takes place in the context of tissue repair. This article discusses cellular and molecular mechanisms involved in the intimate cooperation of neutrophils and macrophages in Leishmania infection.
authors.affiliation: Centro de Ciências da Saúde, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), 21949-900 Rio de Janeiro, RJ, Brazil. gdosreis@biof.ufrj.br
authors.forename: Alessandra A
authors.initials: AA
authors.lastname: Filardy
authors.forename: Dayana R
authors.initials: DR
authors.lastname: Pires
authors.forename: George A
authors.initials: GA
authors.lastname: DosReis
mesh_terms: D000818:Animals; D006801:Humans; D007110:Immunity, Active; D007896:Leishmaniasis / Q000276:immunology*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*