title: [A case of advanced upper gingival carcinoma responding completely to concurrent chemoradiotherapy with S-1].
abstract: We report a case of advanced upper gingival carcinoma with a contralateral metastatic lymph node invading the maxillary sinus (T4aN2cM0). An 83-year-old man was treated concurrently with chemoradiotherapy and S-1. S-1 (80 mg/body/day) was administered for 2 weeks followed by a 1-week rest period as one course. Radiation therapy involved a total of 60 Gy (2 Gy/day; 5 days/week). There were side effects of mild leucopenia and a grade 2 stomatitis. After the completion of 2 courses and radiation therapy, the primary tumor disappeared, and the patient achieved a pathologically complete response. The metastatic lymph node also completely disappeared. S-1 was then administered in the same regimen for 1 year. Neither local recurrence nor distant metastasis has been detected 2 years after the completion of the concurrent chemoradiotherapy with S-1.
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, Kouseikai Takai Hospital, Japan.
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Yamanaka
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Tamaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimomura
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Imai
authors.forename: Tomonori
authors.initials: T
authors.lastname: Sasahira
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Kirita
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005887:Gingival Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid