title: Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention.
abstract: T helper cell 22 (Th22) is a new subset of T cells clearly separate from Th17 and other known T cell subsets with distinct gene expression and function. With the CCR6 + CCR4 + CCR10 + phenotype and aryl hydrocarbon receptor as the key transcription factor, Th22 subsets produce cytokines such as IL-22, whose function depends on the activation of signal transduction and activators of transcription 3. IL-22 was up-regulated in Rheumatoid arthritis, Crohn's disease, Psoriasis, and atopic dermatitis patients whereas it was down-regulated in the serum of patients with sarcoidosis and systemic lupus erythematosus. Furthermore, it has been demonstrated that IL-22 may have promise as a potential therapeutic for chronic inflammatory diseases, and treatment with recombinant cytokine or gene therapy delivery of IL-22 may alleviate tissue destruction during inflammatory responses. In summary, Th22 cell plays an important and complicated role in inflammatory and autoimmune disease.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People's Republic of China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D015316:Genetic Therapy; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D007378:Interleukins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D000097043:Interleukin-22