title: HLA-C locus and genetic susceptibility to psoriatic arthritis in Romanian population.
abstract: We determined the distribution of human leukocyte antigen-C (HLA-C) allelic groups in a cohort of psoriatic arthritis (PsA) patients and a control population of Romanian ethnicity. A nominal association of HLA-C*06 with susceptibility to PsA was observed [P = 0.014, p(corr) > 0.05, odds ratio (OR) 2.1, 95% confidence interval (CI) 1.08-4.46]. When subanalyzing data according to PsA clinical phenotypes, association was noticed between HLA-C*06 and PsA with psoriasis onset before 40 years (p(corr) = 0.013, OR 3.7, 95% CI 1.58-9). This first report from Romania confirmed the association of HLA-C*06 with type I psoriasis in PsA patients. Other study findings, such as the relationship between HLA-C*06 and spondylitis or the protective effect of HLA-C*07 for the polyarthritis clinical phenotype of PsA, are of preliminary character and require verification.
authors.affiliation: Department of Immunology and Pathophysiology, Faculty of Medicine, University Carol Davila, Bucharest, Romania. oliviapopa@yahoo.com
authors.forename: O M
authors.initials: OM
authors.lastname: Popa
authors.forename: L
authors.initials: L
authors.lastname: Popa
authors.forename: M I
authors.initials: MI
authors.lastname: Dutescu
authors.forename: M
authors.initials: M
authors.lastname: Bojinca
authors.forename: V
authors.initials: V
authors.lastname: Bojinca
authors.forename: C
authors.initials: C
authors.lastname: Ciofu
authors.forename: C
authors.initials: C
authors.lastname: Bara
authors.forename: F
authors.initials: F
authors.lastname: Mrazek
authors.forename: M
authors.initials: M
authors.lastname: Petrek
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D012383:Romania / Q000453:epidemiology
chemical_list: D015236:HLA-C Antigens