title: [Neurochemical mechanisms of antidepressant action of new adenine derivative].
abstract: We have studied the influence of the new adenine derivative VMA-99-82 on the exchange of monoamines and their metabolites in the brain of Wistar rats. In addition, the effect of VMA-99-82 on binding of 5-HT1A and 5-HT2A serotonin receptors and the system of 3H-serotonin reuptake in the brain synaptosomes has been studied in vitro. It is established that VMA-99-82 at a dose of 10 mg/kg has no affinity to 5-HT1A and 5-HT2A serotonin receptors and produces no effect on the reuptake of [3H]-5-HT. It is suggested that VMA-99-82 has a modulating effect on ion channel NMDA receptor complex of the glutamatergic system, which leads to the manifestation of antidepressant activity.
authors.forename: D G
authors.initials: DG
authors.lastname: Kovalev
authors.forename: I A
authors.initials: IA
authors.lastname: Zimin
authors.forename: L A
authors.initials: LA
authors.lastname: Smirnova
authors.forename: A F
authors.initials: AF
authors.lastname: Riabukha
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D016194:Receptors, N-Methyl-D-Aspartate; D011985:Receptors, Serotonin; D000225:Adenine