title: Brucellosis in pregnancy.
abstract: This study was undertaken in order to evaluate the effect of brucellosis in pregnancy. The serum agglutination test, Coombs and/or blood culture systems were used in the diagnosis of brucellosis. From July 2003 to September 2010, the clinical and delivery patterns of 40 healthy pregnant women were compared with 39 pregnant women who had brucellosis. There were no birth defects, anomalies or mortalities. We observed that brucellosis in pregnancy increases the incidence of preterm delivery (P = 0.01) and low birth weight (P = 0.001) from that seen in general deliveries. A cephtriaxone/rifampicin combination was found to be the most effective treatment in pregnant women infected with brucellosis (P = 0.004). Brucellosis in pregnancy has no effect on the incidence of congenital malformations or stillbirths. Preterm delivery and low birth weight can be seen as pregnancy outcomes in brucellosis. Appropriate antimicrobial therapy of brucellosis in pregnancy will reduce morbidity and prevent complications.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Diyarbakir State Hospital, Diyarbakir, Turkey. serdagulsun@gmail.com
authors.forename: Serda
authors.initials: S
authors.lastname: Gulsun
authors.forename: Selda
authors.initials: S
authors.lastname: Aslan
authors.forename: Omer
authors.initials: O
authors.lastname: Satici
authors.forename: Talip
authors.initials: T
authors.lastname: Gul
mesh_terms: D000328:Adult; D000372:Agglutination Tests; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000097:blood; D017347:Brucella melitensis / Q000302:isolation & purification*; D002006:Brucellosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016022:Case-Control Studies; D003298:Coombs Test; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D011256:Pregnancy Outcome; D047928:Premature Birth; D012293:Rifampin / Q000627:therapeutic use*; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D000907:Antibodies, Bacterial; D012293:Rifampin