title: A case of Candida haemulonii osteitis: clinical features, biochemical characteristics, and antifungal resistance profile.
abstract: We describe here the first case of osteitis caused by Candida haemulonii in a young immunocompetent patient. This patient presented a history of severe peripheral vascular disease associated with a lack of hygienic conditions as the only risk factors for such an uncommon infection. Clinical signs and histological examination allowed us to determine that it was a C. haemulonii infection and not colonization. The outcome was favourable with oral voriconazole therapy and surgical revascularization. An environmental cause of such infections is most probable, as C. haemulonii has previously been isolated from different non-human sources. Identification methods, results obtained with three in vitro antifungal susceptibility methods and clinical features are reported.
authors.affiliation: Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Nîmes, Faculté de Médecine de Montpellier-Nîmes, Université Montpellier I, Montpellier, France.
authors.forename: J
authors.initials: J
authors.lastname: Crouzet
authors.forename: A
authors.initials: A
authors.lastname: Sotto
authors.forename: E
authors.initials: E
authors.lastname: Picard
authors.forename: L
authors.initials: L
authors.lastname: Lachaud
authors.forename: N
authors.initials: N
authors.lastname: Bourgeois
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008853:Microscopy; D010000:Osteitis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology; D014481:United States; D014656:Vascular Surgical Procedures; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole