title: [A case of lung cancer with skin metastases responding to erlotinib].
abstract: The patient was a 67-year-old female with left lung adenocarcinoma T2N2M1(brain).She received systemic chemothera- py(cisplatin/docetaxel)and stereotactic radiosurgery.She showed a partial response and PET-CT evidenced no new metastasis. So she underwent left pneumonectomy(LtUt S6S8, adenocarcinoma mixed type pT2pN0).One month later, a small nodule appeared on the dorsal surface of her left hand.Excisional biopsy showed adenocarcinoma metastasis of lung cancer. Soon afterward, multiple skin nodules appeared and were diagnosed multiple skin metastases.Erlotinib was administered. After two weeks, skin metastases were reduced significantly, and she was treated with erlotinib on an outpatient basis for 5 months.This is, to our knowledge, the first case in which skin metastases of lung cancer responded to erlotinib.Our experience suggests erlotinib administration at an early treatment has fewer side effects in therapy for metastatic lung cancer.
authors.affiliation: Dept. of Surgery, Ogachi Chuo Hospital.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Yosihiro
authors.initials: Y
authors.lastname: Minamiya
authors.forename: Manabu
authors.initials: M
authors.lastname: Okuyama
authors.forename: Masanori
authors.initials: M
authors.lastname: Hibino
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kudo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tenma
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakamura
authors.forename: Junichi
authors.initials: J
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000069347:Erlotinib Hydrochloride; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000556:secondary
chemical_list: D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000069347:Erlotinib Hydrochloride