title: [Sensitivity of the epidemic and pandemic influenza virus strains to zanamivir (Relenze) in in vitro experiments].
abstract: The paper presents the results of the first Russian experience in evaluating the sensitivity of the epidemic and pandemic influenza virus strains, circulating in the period 2009-2010, to the anti-neuraminidase drug zanamivir. A complex of studies, including enzyme immunoassay, fluorometric assay and partial sequence of the neuraminidases (NA1 and NA2) from influenza A virus strain, was applied. The findings Indicate that all the test strains, including those resistant to oseltamivir, were susceptible to zanamivir. The latter is recommended by the WHO for the prevention and treatment of influenza in pregnant women.
authors.forename: D K
authors.initials: DK
authors.lastname: L'vov
authors.forename: E I
authors.initials: EI
authors.lastname: Burtseva
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
authors.forename: N V
authors.initials: NV
authors.lastname: Beliakova
authors.forename: E S
authors.initials: ES
authors.lastname: Shevchenko
authors.forename: L V
authors.initials: LV
authors.lastname: Kolobukhina
authors.forename: L N
authors.initials: LN
authors.lastname: Merkulova
authors.forename: A G
authors.initials: AG
authors.lastname: Prilipov
authors.forename: I A
authors.initials: IA
authors.lastname: Leneva
authors.forename: N I
authors.initials: NI
authors.lastname: Baranov
authors.forename: V N
authors.initials: VN
authors.lastname: Gorelikov
authors.forename: D D
authors.initials: DD
authors.lastname: Abramov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D004196:Disease Outbreaks; D004285:Dogs; D024882:Drug Resistance, Viral; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects* / Q000201:enzymology; D009981:Influenza B virus / Q000187:drug effects* / Q000201:enzymology; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology; D008826:Microbial Sensitivity Tests; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D053139:Oseltamivir / Q000494:pharmacology; D012426:Russia / Q000453:epidemiology; D014764:Viral Proteins / Q000037:antagonists & inhibitors; D053243:Zanamivir / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins; D053139:Oseltamivir; D009439:Neuraminidase; D053243:Zanamivir