title: Efficacy of Damus-Kaye-Stansel procedure in patients with univentricular heart associated with ventriculo-arterial discordance and excessive pulmonary blood flow.
abstract: Pulmonary artery banding (PAB) and ventriculo-arterial discordance (VAD) were reported to be risk factors of subaortic stenosis in univentricular heart. The aim of this study was to evaluate efficacy of Damus-Kaye-Stansel (DKS) anastomosis. Of all 89 patients undergoing total cavo-pulmonary connection (TCPC) in our center since April 1996, 38 had VAD with high pulmonary blood flow, and had received PAB. Twenty-one of 38 had undergone DKS anastomosis due to subaortic stenosis or due to morphological hypertrophy of the outlet septum (DKS group); the other 17 had not yet (no-DKS group). Percentage end-systolic volume of the systemic ventricle and percentage subaortic lesion in both groups significantly decreased after TCPC (P<0.01). Pressure gradient across systemic outflow tract after TCPC was low in both groups at rest. The gradient in DKS group did not differ from those in control group with ventriculo-arterial concordance (VAC) (P>0.1). Ventricular outflow tract after DKS anastomosis might behave like that of VAC even when dobutamine is loaded, suggesting that the anastomosis should be carried out in many patients with this entity even if stenosis across systemic ventricular outflow is not significant, considering possible stenosis in the future.
authors.affiliation: Department of Pediatric Cardiovascular Surgery, Osaka City General Hospital, Miyakojimaku, Osaka 534-0021, Japan. ykawahir@mac.com
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kawahira
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Nishigaki
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Maehata
mesh_terms: D000704:Analysis of Variance; D001024:Aortic Valve Stenosis / Q000503:physiopathology / Q000601:surgery*; D018729:Fontan Procedure / Q000009:adverse effects; D018610:Heart Bypass, Right / Q000009:adverse effects; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006352:Heart Ventricles / Q000002:abnormalities / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D011652:Pulmonary Circulation; D012039:Regional Blood Flow; D013997:Time Factors; D016896:Treatment Outcome; D016276:Ventricular Function