title: The evolution of adult-onset Still disease: an observational and comparative study in a cohort of 76 Italian patients.
abstract: OBJECTIVE
  Adult-onset Still's disease (AOSD) is a potentially crippling or life-threatening rare disease that may be self-limited, intermittent, and chronic. Clinical predictors of outcome are still lacking, as is information on the rate of progress of its chronic course. The main objective is to identify factors that improve our ability to predict the course of AOSD, and factors associated with the rate of progress of its chronic course. A comparison with the literature is included.
  
  
  METHODS
  A retrospective cohort observational study conducted at the tertiary-referral Rheumatology Unit in Ferrara, Italy.
  
  
  RESULTS
  Seventy-six patients (44 females and 32 males) referred to the Unit and who satisfied the criteria for AOSD were identified. Our findings on white AOSD patients are largely compatible with those previously published. Ferritin level, as well disease activity score (DAS(28)), is associated with the rate of progression of the articular manifestations of the disease. A polyarthritis persisting over 6 months is associated with the development of a chronic articular course, irrespective of the size of the involved joints.
  
  
  CONCLUSIONS
  Ferritin, being associated with the course of AOSD, could play a role in the diagnosis of the disease. Together with DAS(28), it might also serve as a useful predictor for the rate of progress of the chronic course of the disease, as measured with simple erosion narrowing score.
authors.affiliation: Rheumatology Section, Department of Clinical And Experimental Medicine, University of Ferrara, Ferrara, Italy. matteo.colina@gmail.com
authors.forename: Matteo
authors.initials: M
authors.lastname: Colina
authors.forename: Walter
authors.initials: W
authors.lastname: Zucchini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ciancio
authors.forename: Carlo
authors.initials: C
authors.lastname: Orzincolo
authors.forename: Francesco
authors.initials: F
authors.lastname: Trotta
authors.forename: Marcello
authors.initials: M
authors.lastname: Govoni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016706:Still's Disease, Adult-Onset / Q000097:blood / Q000175:diagnosis*
chemical_list: D005293:Ferritins