title: Endogenous secretory receptor for advanced glycation end products and chronic kidney disease in the elderly population.
abstract: OBJECTIVE
  The relationship of circulating endogenous secretory receptor for advanced glycation end products (esRAGE) and chronic kidney disease (CKD) has not been well characterized. The aim of the study was to determine whether plasma esRAGE is associated with CKD and is predictive of developing CKD in older adults.
  
  
  METHODS
  The relationship between plasma esRAGE and CKD (more than stage 3 of the National Kidney Foundation classification; estimated glomerular filtration rate <60 ml/min/1.73 m(2)) and CKD over 6 years of follow-up was examined in a cross-sectional and prospective study design in 1,016 men and women, ≥65 years, in the InCHIANTI study, a population-based cohort study of aging in Tuscany, Italy.
  
  
  RESULTS
  At enrollment, 158 (15.5%) had CKD. Mean (SD) plasma esRAGE was 0.45 (0.24) ng/ml. Plasma esRAGE (ng/ml) was associated with CKD (odds ratio per 1 SD = 1.30; 95% CI 1.1-1.6; p < 0.005) in a multivariable logistic regression model, adjusting for potential confounders. Plasma esRAGE was an independent predictor of incident CKD over 6 years of follow-up (hazard ratio per 1 SD = 1.37; 95% CI 1.1-1.7; p < 0.008) in a multivariable Cox proportional hazards model, adjusting for potential confounders.
  
  
  CONCLUSIONS
  Elevated plasma esRAGE is independently associated with CKD and is an independent predictor of incident CKD in older community-dwelling adults.
authors.affiliation: Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Mansi
authors.initials: M
authors.lastname: Dalal
authors.forename: Richard D
authors.initials: RD
authors.lastname: Semba
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.forename: Candace
authors.initials: C
authors.lastname: Crasto
authors.forename: Ravi
authors.initials: R
authors.lastname: Varadhan
authors.forename: Stefania
authors.initials: S
authors.lastname: Bandinelli
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Fink
authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D016016:Proportional Hazards Models; D011446:Prospective Studies; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism*; D012044:Regression Analysis; D051436:Renal Insufficiency, Chronic / Q000378:metabolism; D013997:Time Factors
chemical_list: D000067759:Receptor for Advanced Glycation End Products