title: [Possibilities of radionuclide study of lower-limb muscles perfusion in diagnosis of chronic arterial insufficiency].
abstract: The authors have hereby proposed a method to diagnose lower-limb muscular ischaemia by means of scintigraphy, used in 35 patients suffering from atherosclerosis obliterans with stage IIB and III A chronic arterial insufficiency of limbs. To do so, administration of the radioactive agent "Myoview" (⁹⁹m)Tc-tetrophosmine) manufactured by the "Nycomed" Company into a patient's peripheral vein was followed by assessing its accumulation in lower-limb muscles at rest and after standard physical load. Alterations in the parameters studied relative to the norm made it possible to judge on the presence of lower-limb circulatory impairments. The method proved highly efficient, thus making it possible to use it for both therapeutic decision-making and probably in future for dynamic control after the treatment performed. Minimally invasive nature and simplicity in use of the methodology open wide possibilities for its use.
authors.forename: A V
authors.initials: AV
authors.lastname: Karalkin
authors.forename: M R
authors.initials: MR
authors.lastname: Kuznetsov
authors.forename: S A
authors.initials: SA
authors.lastname: Tepliakov
authors.forename: B V
authors.initials: BV
authors.lastname: Tugdumov
authors.forename: E I
authors.initials: EI
authors.lastname: Rumiantseva
mesh_terms: D000328:Adult; D001162:Arteriosclerosis Obliterans / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003937:Diagnosis, Differential; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds / Q000008:administration & dosage; D015609:Organotechnetium Compounds / Q000008:administration & dosage; D055420:Perfusion Imaging / Q000379:methods*; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D012039:Regional Blood Flow / Q000502:physiology*; D015203:Reproducibility of Results; D012720:Severity of Illness Index
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin