title: Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging.
abstract: OBJECTIVE
  In the current study, our aim was to demonstrate that EmbryoScope incubation conditions is comparable to standard laboratory incubation circumstances by comparing embryo quality, development and ongoing pregnancy rates between the EmbryoScope (ES) and a standard incubator (SI). We analyzed 478 embryos from 60 couples undergoing oocyte donation were included in the study.
  
  
  METHODS
  All embryos retrieved from a patient were randomly distributed in the ES or SI. We calculated blastocyst development rate, blastocyst viability and ongoing pregnancy rate for embryo transfers from ES, SI and mixed (one embryo from the ES and one from the SI). Statistical analysis was conducted by Chi square tests, considering p < 0.05 significant.
  
  
  RESULTS
  No significant differences were found between the ES and SI from all the parameters evaluated.
  
  
  CONCLUSIONS
  Thus we concluded that time-lapse monitoring in the EmbryoScope does not impair embryo quality while allowing for morphological, spatial and temporal analysis of embryo development.
authors.affiliation: Instituto Valenciano de Infertilidad, Alicante, Spain. mcruz@ivi.es
authors.forename: María
authors.initials: M
authors.lastname: Cruz
authors.forename: Blanca
authors.initials: B
authors.lastname: Gadea
authors.forename: Nicolás
authors.initials: N
authors.lastname: Garrido
authors.forename: Kamilla Søe
authors.initials: KS
authors.lastname: Pedersen
authors.forename: Mar
authors.initials: M
authors.lastname: Martínez
authors.forename: Inma
authors.initials: I
authors.lastname: Pérez-Cano
authors.forename: Manuel
authors.initials: M
authors.lastname: Muñoz
authors.forename: Marcos
authors.initials: M
authors.lastname: Meseguer
mesh_terms: D001755:Blastocyst / Q000166:cytology / Q000378:metabolism*; D002970:Cleavage Stage, Ovum / Q000166:cytology / Q000502:physiology; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000592:standards*; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D018587:Oocyte Donation; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D059008:Time-Lapse Imaging