title: Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling.
abstract: Exaggerated recall for fear-provoking events leads to abnormal behaviors. We hypothesized that tuberoinfundibular-peptide-of-39-residues (TIP39) modulates fear memory by limiting long-term consequences of aversive experiences. We now show that mice lacking TIP39 signaling display enhanced fear-recall, anxiety and depression-like behavior 2 weeks after a traumatic event. We suggest that TIP39 modulates long-term fear recall and that mice lacking TIP39 or its receptor are tools for investigating fear-related psychopathologies.
authors.affiliation: Section on Fundamental Neuroscience, NIMH, National Institutes of Health (NIH), 35 Convent Drive, 20892 Bethesda, MD, USA.
authors.forename: Laurence
authors.initials: L
authors.lastname: Coutellier
authors.forename: Ted B
authors.initials: TB
authors.lastname: Usdin
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000503:physiopathology*; D001362:Avoidance Learning / Q000502:physiology; D003863:Depression / Q000235:genetics / Q000503:physiopathology*; D004195:Disease Models, Animal; D005106:Exploratory Behavior; D005239:Fear / Q000502:physiology*; D018782:Maze Learning; D057567:Memory, Long-Term / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009687:Nuclear Proteins / Q000172:deficiency*; D000072260:RNA Splicing Factors; D016601:RNA-Binding Proteins; D044183:Receptor, Parathyroid Hormone, Type 2 / Q000172:deficiency; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D013997:Time Factors; D033921:Vesicular Transport Proteins / Q000172:deficiency*
chemical_list: D009687:Nuclear Proteins; D000072260:RNA Splicing Factors; D016601:RNA-Binding Proteins; D044183:Receptor, Parathyroid Hormone, Type 2; C412229:Tfip11 protein, mouse; D033921:Vesicular Transport Proteins