title: [Acute lethal poisoning with venlafaxine].
abstract: The case of acute venlafaxine poisoning with fatal outcome is shown. The 52-year-old woman with depression disorder ingested 56 pills of Symfaxin ER 150 venlafaxine as a suicidal attempt. Initially she was observed in the Neurology Department because of seizures, but after her husband found empty packages of medicine she was sent to the Toxicology Department being suspected of venlafaxine poisoning. The qualitative toxicological test confirmed the presence of venlafaxine in urine. In the course of poisoning rhabdomiolysis, hypotension and consecutive acute renal failure were observed. Finally, severe ventricular tachyarrhythmia occurred leading do cardiac arrest. Despite intensive symptomatic and supportive treatment the patient died.
authors.affiliation: Klinika Toksykologii i Chorób Srodowiskowych, Katedra Toksykologii i Chorób Srodowiskowych UJCM, Kraków.
authors.forename: Dorota
authors.initials: D
authors.lastname: Szpak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Ciszowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gawlikowski
authors.forename: Ewa
authors.initials: E
authors.lastname: Krzyzanowska-Kierepka
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D003511:Cyclohexanols / Q000506:poisoning*; D003866:Depressive Disorder / Q000188:drug therapy*; D062787:Drug Overdose; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D013405:Suicide; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D000069470:Venlafaxine Hydrochloride