title: Venous thromboembolism in patients with pancreatic cancer: implications of circulating tissue factor.
abstract: Among cancers, pancreatic cancer is known to be associated with a higher incidence of venous thromboembolism (VTE). The aim of the study was to determine the implication of circulating tissue factor (TF) in VTE related to active pancreatic cancer. One hundred and sixty-four consecutive patients who participated to the Etude des Determinants et Interactions de la Thrombose veineuse (EDITH) study between January 2005 and August 2007 for symptomatic VTE related to active pancreatic cancer (n = 8), active cancer of other location (n = 42) or classified as unprovoked (n = 114) were included. TF activity (TFa) was measured in a one-stage kinetic chromogenic method. There were no differences of median TFa levels between patients with VTE related to cancer of other type than pancreas [2.01 pmol/l range (0.05-43.92)] and patients with unprovoked VTE [1.78 pmol/l (range 0.05-63.72), P = 0.21]. Median TFa levels were higher in patients with VTE related to pancreatic cancer [12.67 pmol/l (range 0.05-112.04)] than in patients with VTE related to cancer of other type [2.01 pmol/l (range 0.05-43.92), P = 0.02]. Higher levels of circulating TFa during the course of pancreatic cancer may explain the higher incidence of VTE associated with this type of cancer.
authors.affiliation: Département de Médecine Interne et Pneumologie, Faculté de Médecine et des Sciences de la Santé, Université de Brest, CHU de Brest, Brest, France. aurelien.delluc@chu-brest.fr
authors.forename: Aurélien
authors.initials: A
authors.lastname: Delluc
authors.forename: Aurélie
authors.initials: A
authors.lastname: Rousseau
authors.forename: Céline
authors.initials: C
authors.lastname: Delluc
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Le Moigne
authors.forename: Grégoire
authors.initials: G
authors.lastname: Le Gal
authors.forename: Dominique
authors.initials: D
authors.lastname: Mottier
authors.forename: Patrick
authors.initials: P
authors.lastname: Van Dreden
authors.forename: Karine
authors.initials: K
authors.lastname: Lacut
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D011446:Prospective Studies; D013925:Thromboplastin / Q000032:analysis* / Q000096:biosynthesis; D054556:Venous Thromboembolism / Q000097:blood* / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D013925:Thromboplastin