title: [Influence of FGF2 level on the inflammation phase dynamics at the postinfarction cardiosclerosis].
abstract: We modeling myocardial infarction female Wistar rats (N=126). We used morphomethry for examination of infarction zone from 2 h to 30 days after operation. The study comprised three groups of animals: "Control", "FGF" with 100 Hz FCGF2 injection into left ventricle, "anti-FGF" with 2 microg monoclonal antiFCF2 antibodies injections at period 1.5 h, 6 h and 3 day after operation. We founded that FCF2 injections leaded to enlarged of infiltrative inflammatory stage and take effect on the early collagen synthesis in infarction regions (from 3 days in group with FGF2 injection vs. 7 days in control group). Opportunity,injection of anti-FCF2 antibodies leaded to decreasing collagen volume on 30 day after infarction (19.15 +/- 1.22% in "anti-FGF" group vs. 41.71 +/- 1.30% in "Control" group, p < 0.05).
authors.forename: M G
authors.initials: MG
authors.lastname: Shurygin
authors.forename: I A
authors.initials: IA
authors.lastname: Shurygina
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012598:Sclerosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
chemical_list: D000906:Antibodies; D016222:Fibroblast Growth Factor 2; D003094:Collagen