title: Early events of HIV-1 infection: can signaling be the next therapeutic target?
abstract: Intracellular signaling events are signposts of biological processes, which govern the direction and action of biological activities. Through millions of years of evolution, pathogens, such as viruses, have evolved to hijack host cell machinery to infect their targets and are therefore dependent on host cell signaling for replication. This review will detail our current understanding of the signaling events that are important for the early steps of HIV-1 replication. More specifically, the therapeutic potential of signaling events associated with chemokine coreceptors, virus entry, viral synapses, and post-entry processes will be discussed. We argue that these pathways may represent novel targets for antiviral therapy.
authors.affiliation: Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia.
authors.forename: Kate L
authors.initials: KL
authors.lastname: Jones
authors.forename: Redmond P
authors.initials: RP
authors.lastname: Smyth
authors.forename: Cândida F
authors.initials: CF
authors.lastname: Pereira
authors.forename: Paul U
authors.initials: PU
authors.lastname: Cameron
authors.forename: Sharon R
authors.initials: SR
authors.lastname: Lewin
authors.forename: Anthony
authors.initials: A
authors.lastname: Jaworowski
authors.forename: Johnson
authors.initials: J
authors.lastname: Mak
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D018390:Gene Targeting / Q000379:methods*; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D015497:HIV-1 / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics*; D013997:Time Factors; D053586:Virus Internalization / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects / Q000235:genetics / Q000502:physiology
chemical_list: D019380:Anti-HIV Agents