title: Targeting translation dependence in cancer.
abstract: A challenge in cancer therapy is to selectively target activities that are essential for survival of malignant cells while sparing normal cells. Translational control represents a potential anti-neoplastic target because it is exerted by major signaling pathways that are often usurped in cancers. Herein we describe approaches being developed that target eukaryotic initiation factor (eIF) 4F, a heterotrimeric complex that integrates multiple signaling inputs to the translation apparatus.
authors.affiliation: Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada.
authors.forename: Abba
authors.initials: A
authors.lastname: Malina
authors.forename: Regina
authors.initials: R
authors.lastname: Cencic
authors.forename: Jerry
authors.initials: J
authors.lastname: Pelletier
mesh_terms: D000818:Animals; D039562:Eukaryotic Initiation Factor-4F / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy*
chemical_list: D039562:Eukaryotic Initiation Factor-4F