title: Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesion.
abstract: Coeliac disease is a chronic inflammation of the intestinal mucosa controlled by gluten-specific T cells restricted by disease-associated HLA-DQ molecules. We have previously reported that mucosal CD11c(+) dendritic cells (DCs) are responsible for activation of gluten-reactive T cells within the coeliac lesion. In mice, intestinal CD11c(+) DCs comprise several functionally distinct subsets. Here, we report that HLA-DQ(+) antigen-presenting cells (APCs) in normal human duodenal mucosa can be divided into four subsets with striking similarities to those described in mice: CD163(+) CD11c(-) macrophages (74%), and CD11c(+) cells expressing either CD163 (7%), CD103 (11%) or CD1c (13%). CD103(+) and CD1c(+) DCs belonged to partly overlapping populations, whereas CD163(+) CD11c(+) APCs appeared to be a distinct population. In the coeliac lesion, we found increased density of CD163(+) CD11c(+) APCs, whereas the density of CD103(+) and CD1c(+) DCs was decreased, suggesting that distinct subpopulations of APCs in coeliac disease may exert different functions in the pathogenesis.
authors.affiliation: Centre for Immune Regulation, Institute of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway. Ann-Christin.Beitnes@rr-research.no
authors.forename: A-C R
authors.initials: AC
authors.lastname: Beitnes
authors.forename: M
authors.initials: M
authors.lastname: Ráki
authors.forename: K E A
authors.initials: KE
authors.lastname: Lundin
authors.forename: J
authors.initials: J
authors.lastname: Jahnsen
authors.forename: L M
authors.initials: LM
authors.lastname: Sollid
authors.forename: F L
authors.initials: FL
authors.lastname: Jahnsen
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000276:immunology*; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology*; D039521:CD11c Antigen / Q000276:immunology*; D002446:Celiac Disease / Q000276:immunology* / Q000473:pathology; D002452:Cell Count; D003713:Dendritic Cells / Q000276:immunology*; D004386:Duodenum / Q000276:immunology / Q000473:pathology; D005260:Female; D006683:HLA-DQ Antigens / Q000276:immunology*; D006801:Humans; D039001:Integrin alpha Chains / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000276:immunology*; D055815:Young Adult; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D039521:CD11c Antigen; D000098902:CD163 Antigen; D006683:HLA-DQ Antigens; D039001:Integrin alpha Chains; D011956:Receptors, Cell Surface; C091367:alpha E integrins