title: [Effect of additional administration of iron ions on the efficacy of radiotherapy of glioma-bearing animals].
abstract: Our analysis failed to establish any antitumor effect of treatment of rats with transplantable glioma-35 with iron-containing mineral drinking water (ICMW). The latter treatment combined with irradiation (15 Gy) was followed by enhanced genotoxic effect in white blood cells. Post-irradiation administration of ICMW did not influence glioma growth significantly as compared with radiation alone. Pre- and post-iradiation drinking of ICMW resulted in marked leukopenia 24 hrs after exposure as well as to significant decrease in tumor size (20-40 days after of experiment) as compared with control.
authors.forename: S D
authors.initials: SD
authors.lastname: Ivanov
authors.forename: A L
authors.initials: AL
authors.lastname: Semënov
authors.forename: E G
authors.initials: EG
authors.lastname: Kovan'ko
authors.forename: V A
authors.initials: VA
authors.lastname: Iamshanov
authors.forename: M A
authors.initials: MA
authors.lastname: Zabezhinskiĭ
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D005910:Glioma / Q000532:radiotherapy*; D007477:Ions / Q000008:administration & dosage; D019266:Iron, Dietary / Q000008:administration & dosage*; D008297:Male; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D051381:Rats; D013997:Time Factors; D017211:Treatment Failure; D014867:Water
chemical_list: D007477:Ions; D019266:Iron, Dietary; D014867:Water