title: The effects of an arabinogalactan-protein from the white-skinned sweet potato (Ipomoea batatas L.) on blood glucose in spontaneous diabetic mice.
abstract: We examined the effects of an arabinogalactanprotein (WSSP-AGP) from Ipomoea batatas L. on hyperglycemia in db/db mice. An oral glucose tolerance test indicated significantly decreased plasma glucose levels by WSSP-AGP. Additionally, an insulin tolerance test found improvement in insulin sensitivity due to treatment with WSSP-AGP. This suggests that amelioration of insulin resistance by WSSP-AGP causes to lead its hypoglycemic effects.
authors.affiliation: Research Institute, Fuji-Sangyo Co., Ltd., Marugame, Kagawa, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Oki
authors.forename: Seiko
authors.initials: S
authors.lastname: Nonaka
authors.forename: Sei
authors.initials: S
authors.lastname: Ozaki
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects*; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000097:blood; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D027723:Ipomoea batatas / Q000737:chemistry; D051379:Mice; D008822:Mice, Transgenic; D009088:Mucoproteins / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D000077205:Pioglitazone; D010940:Plant Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D009088:Mucoproteins; D010940:Plant Proteins; D045162:Thiazolidinediones; C006619:arabinogalactan proteins; D000077205:Pioglitazone