title: The inflammatory modulation effect of glutamine-enriched total parenteral nutrition in postoperative gastrointestinal cancer patients.
abstract: The objective of this study is to explore the inflammatory modulation effect of glutamine-enriched total parenteral nutrition (TPN) by investigating the alterations of inflammation-related cytokines in gastrointestinal (GI) cancer patients postoperatively. Fifty GI cancer patients received postoperative 7 days of isocaloric and isonitrogenous TPN after operation. They were randomly divided to receive either glutamine-enriched TPN or standard TPN. The inflammation-related cytokines including interleukin-6, interleukin-10, and tumor necrosis factor-α were also determined. Records of nutritional assessments, inflammatory status, and postoperative complications were compared between the two groups. Of 50 enrolled patients, 25 patients were classified as the intervention group, and the control group also comprised 25 patients. The differences of gender, age, primary GI malignancies, and hematological and biochemical data between the two compared groups were not statistically significant (all P > 0.05). Compared with standard TPN, a higher serum prealbumin level and better nitrogen balance were observed in glutamine-enriched TPN (P = 0.039 and 0.048 respectively). A significantly lower serum interleukin-6 level was found in comparing glutamine-enriched with standard TPN (P = 0.01), but not in interleukin-10 (P = 0.374) and tumor necrosis factor-α levels (P = 0.653). Moreover, a significant lower serum C-reactive protein level was detected in glutamine-enriched TPN compared with standard TPN (P = 0.013). Indeed, four cases of postoperative infectious complications were noted in the control group, but no postoperative infectious complications were observed in the interventional group (P = 0.037). Our present study shows that glutamine-enriched TPN may be beneficial in improving the inflammatory status and decreasing the infectious morbidity in postoperative GI cancer patients.
authors.affiliation: Nutrition Support Team, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Lu
authors.forename: Ying-Ling
authors.initials: YL
authors.lastname: Shih
authors.forename: Li-Chu
authors.initials: LC
authors.lastname: Sun
authors.forename: Jui-Fen
authors.initials: JF
authors.lastname: Chuang
authors.forename: Cheng-Jen
authors.initials: CJ
authors.lastname: Ma
authors.forename: Fang-Ming
authors.initials: FM
authors.lastname: Chen
authors.forename: Deng-Chyang
authors.initials: DC
authors.lastname: Wu
authors.forename: Jan-Sing
authors.initials: JS
authors.lastname: Hsieh
authors.forename: Jaw-Yuan
authors.initials: JY
authors.lastname: Wang
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000032:analysis; D013505:Digestive System Surgical Procedures / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005973:Glutamine / Q000008:administration & dosage*; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D018836:Inflammation Mediators / Q000032:analysis*; D016753:Interleukin-10 / Q000032:analysis; D008297:Male; D044342:Malnutrition / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D009752:Nutritional Status; D010289:Parenteral Nutrition, Total / Q000379:methods*; D011182:Postoperative Care / Q000379:methods; D011788:Quality of Life; D012016:Reference Values; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D005973:Glutamine; D016753:Interleukin-10; D002097:C-Reactive Protein