title: Lewis acid catalyzed benzylic C-H bond functionalization of azaarenes: addition to enones.
abstract: A Lewis acid catalyzed benzylic C-H bond functionalization of alkyl-substituted azaarenes is described. Sc(OTf)(3) and Y(OTf)(3) promoted the direct addition of alkyl-substituted azaarenes and benzoxazole to enones and an α,β-unsaturated N-acylpyrrole. Products were obtained in 60-96% yield.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Komai
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Yoshino
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Motomu
authors.initials: M
authors.lastname: Kanai
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001372:Aza Compounds; D058116:Lewis Acids; D002244:Carbon; D006859:Hydrogen; D001554:Benzene