title: Characterization of soft contact lens edge fitting using ultra-high resolution and ultra-long scan depth optical coherence tomography.
abstract: OBJECTIVE
  To characterize the edge fitting of soft contact lenses using ultra-high resolution optical coherence tomography (UHR-OCT) and ultra-long scan depth optical coherence tomography (UL-OCT).
  
  
  METHODS
  A total of 20 participants (11 men, 9 women; mean age, 32.3 years) were recruited. Four different types of soft contact lenses were randomly fitted to both eyes of each subject on two separate visits. After 30 minutes, the horizontal meridians of the corneal center, midperiphery, and limbus were imaged by UHR-OCT. UL-OCT imaged each lens in vitro and the ocular surface of a physical model eye.
  
  
  RESULTS
  Angle-edged lenses had significantly less conjunctival buildup than did round-edged lenses (P = 0.008). Limbal post-lens tear film gaps were present in 42% of the eyes, with the round-edged lenses having the most at 68%. Similarly, post-lens tear film gaps at the corneal mid-periphery were present in 47% of all eyes, with the round-edged lens having the most at 75%. Mismatches between the lens and the ocular surface were simulated based on UL-OCT images of the in vitro lenses and the model eye. The existence of tear film gaps and touching points were predicted in the simulation.
  
  
  CONCLUSIONS
  The soft contact lens edge fitting was characterized by the conjunctival buildup and tear film gaps. Different types of contact lenses presented different levels of conjunctival buildup as well as different frequencies of tear film gaps. The findings by UHR-OCT were predicted in the simulation by UL-OCT. The application of these new technologies may open new ways of designing lenses and evaluating their fit.
authors.affiliation: Departments of Ophthalmology, Bascom Palmer Eye Institute, Jacksonville, Florida, USA.
authors.forename: Meixiao
authors.initials: M
authors.lastname: Shen
authors.forename: Lele
authors.initials: L
authors.lastname: Cui
authors.forename: Colleen
authors.initials: C
authors.lastname: Riley
authors.forename: Michael R
authors.initials: MR
authors.lastname: Wang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D003228:Conjunctiva / Q000473:pathology; D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000378:metabolism; D004867:Equipment Design; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D016850:Limbus Corneae / Q000378:metabolism; D008297:Male; D011237:Predictive Value of Tests; D017755:Prosthesis Fitting / Q000379:methods*; D013666:Tears / Q000378:metabolism; D014018:Tissue Distribution; D041623:Tomography, Optical Coherence / Q000379:methods*