title: [Study on implant material of carbon/carbon composites].
abstract: This study was aimed to evaluate the biocompatibility and mechanical property of carbon/carbon composites. At first, carbon/carbon composites were prepared by chemical vapor deposition, and the mechanical property of carbon/carbon composites was tested. The biocompatibility of carbon/carbon composites was evaluated by cytotoxicity test, sensitization test, micronucleus test and implantation test. Mechanical property test showed such carbon/carbon composites are of good compression property and tension property. Cytotoxicity test showed that the leaching liquor of samples has no effect on the growth and proliferation of L-929 cells. The medullary micronucleus frequency of mouse was 2.3 per thousand +/- 0.7 per thousand in experiment group. The sensitization test showed that the skin of the subjects of experiment group had slight erythema and edema, which was 0.188 +/- 0.40 according to Magnusson and Kligman classification. Implantation test revealed that there was slight inflammation around the tissue after the implantation of sample. At 12 weeks, scanning electron microscopy and histopathological exam indicated that the samples of experiment group were of good histocompatibility; and in comparison with control group, there was no significant differences (P > 0.05). So these kinds of samples have good biocompatibility, mechanical property and prospects of clinical application.
authors.affiliation: Third XiangYa Hospital, Central South University, Changsha 410013, China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Wang
authors.forename: Shu
authors.initials: S
authors.lastname: Yu
authors.forename: Shaihong
authors.initials: S
authors.lastname: Zhu
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Yunliang
authors.initials: Y
authors.lastname: Miu
authors.forename: Boyun
authors.initials: B
authors.lastname: Huang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes; D002244:Carbon / Q000737:chemistry*; D002460:Cell Line; D005260:Female; D005269:Femur / Q000601:surgery; D005347:Fibroblasts / Q000166:cytology; D020007:Implants, Experimental; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D011817:Rabbits; D011897:Random Allocation
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002244:Carbon