title: [Genetics of ischemic stroke: where are we now?].
abstract: As stroke is the third leading cause of death after heart failure and tumors worldwide, cerebrovascular diseases reached substantial attention. In the past few years, significant progression has been seen in identification of genetic variants in the background of stroke and other cerebrovascular and cardiovascular events. Examination of these variants is a new approach to recognize pathogenesis of disorders that hopefully helps in future prevention and prospects of screening and, optimistically, it contributes to special care of patients susceptible for stroke. In the background of ischemic stroke several genetic variants have been identified, which localize in genes encoding proteins involved in hemostasis, renin-angiotensin system and lipid metabolism. The number of these variants exponentially increases permanently due to rapid spreading of genome wide association studies. The goal of this review is to summarize the results of genetic studies on ischemic stroke. Here the authors focus on genetic variants which can have major role in personalized medicine and prevention of stroke.
authors.affiliation: Pécsi Tudományegyetem, Általános Orvostudományi Kar Orvosi Genetikai Intézet Pécs Szigeti út 12. 7624.
authors.forename: Anita
authors.initials: A
authors.lastname: Maász
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szolnoki
authors.forename: László
authors.initials: L
authors.lastname: Balikó
authors.forename: Béla
authors.initials: B
authors.lastname: Melegh
mesh_terms: D002545:Brain Ischemia / Q000235:genetics*; D003132:Commerce; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D055106:Genome-Wide Association Study; D006801:Humans; D008279:Magnetic Resonance Imaging; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000235:genetics*; D014057:Tomography, X-Ray Computed