title: Prevalence and contributing factors of nonsusceptibility to imipenem or meropenem in extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Escherichia coli.
abstract: Among the extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli, 3.9% of K. pneumoniae showed nonsusceptibility to imipenem or meropenem; and their mechanism was the combination of ESBL and/or plasmid-mediated AmpC β-lactamase production and porin loss. The presence of bla(CTX-M-14) and loss of OmpK36 were associated with higher carbapenem MICs.
authors.affiliation: Department of Laboratory Medicine, School of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul, 137-701, South Korea. yjpk@catholic.ac.kr
authors.forename: Yeon-Joon
authors.initials: YJ
authors.lastname: Park
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Yu
authors.forename: Kang Gyun
authors.initials: KG
authors.lastname: Park
authors.forename: Yong Gyu
authors.initials: YG
authors.lastname: Park
authors.forename: Seongok
authors.initials: S
authors.lastname: Lee
authors.forename: Soo-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Seok Hoon
authors.initials: SH
authors.lastname: Jeong
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D018272:Porins / Q000235:genetics / Q000378:metabolism; D013845:Thienamycins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D018272:Porins; D013845:Thienamycins; D015378:Imipenem; D001618:beta-Lactamases; D000077731:Meropenem