title: Balancing life and death in the ischemic brain: SIK and TORC weigh in.
abstract: Activation of NMDA receptors during cerebral ischemia triggers signaling pathways that promote both neuronal death and survival. In this issue of Neuron, Sasaki et al. present evidence for a new endogenous survival pathway involving the kinase SIK2 and the CREB coactivator TORC1. The powerful neuroprotection conferred by this pathway has considerable translational potential for stroke therapy.
authors.affiliation: Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY.
authors.forename: Eduardo F
authors.initials: EF
authors.lastname: Gallo
authors.forename: Costantino
authors.initials: C
authors.lastname: Iadecola