title: Biomechanical, histological and ultrastructural analyses of laser micro- and nano-structured titanium implant after 6 months in rabbit.
abstract: Short-term, experimental studies of partly laser-modified implants with nano-scale surface topographical features have recently shown a considerable increase in the biomechanical anchorage to bone. The aim of this study is to evaluate the biomechanical and bone-bonding ability of partly laser-modified implants compared with machined implants after a healing period of 6 months in a rabbit model. The results showed a 170% increase in removal torque. Histology and scanning electron microscopy demonstrated osseointegration for both implant types, but also revealed a different fracture pattern at the interface and in the bone. Transmission electron microscopy and chemical analysis showed coalescence between mineralized tissue and the nano-structured surface of the laser modified implant. Taken together, the results indicate that nano-structured surfaces promote in vivo long-term bone bonding and interface strength.
authors.affiliation: Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden. anders.palmquist@biomaterials.gu.se
authors.forename: Anders
authors.initials: A
authors.lastname: Palmquist
authors.forename: Lena
authors.initials: L
authors.lastname: Emanuelsson
authors.forename: Rickard
authors.initials: R
authors.lastname: Brånemark
authors.forename: Peter
authors.initials: P
authors.lastname: Thomsen
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism*; D005260:Female; D005269:Femur / Q000033:anatomy & histology / Q000378:metabolism; D020007:Implants, Experimental; D007834:Lasers; D008422:Materials Testing; D008854:Microscopy, Electron; D016348:Osseointegration; D011817:Rabbits; D013314:Stress, Mechanical; D013499:Surface Properties; D013977:Tibia / Q000033:anatomy & histology / Q000378:metabolism; D014025:Titanium / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D020099:Coated Materials, Biocompatible; D014025:Titanium