title: Statins and the bariatric patient: characterization and perioperative effects of statin therapy in the gastric bypass patient.
abstract: In surgical patients, statins have been shown to have beneficial effects independent of the lipid-lowering properties. Statin use has not been well studied in the bariatric patient. The objective of this study was to characterize the use of statins in the bariatric surgery patient and compare outcomes, including complications, weight loss, and changes in comorbidities. A retrospective chart review of patients undergoing bariatric surgery between 2005 and 2008 was conducted. Four hundred forty surgical patients charts were reviewed, of which 151 (34%) were taking a perioperative statin. The two groups were similar in length of stay, baseline body mass index, type of procedure, smoking status, and hospital charges. However, the statin group was older, more likely male, and with more baseline comorbidities, including hypertension (HTN), hyperlipidemia (HLD), diabetes mellitus (DM), coronary artery disease, and obstructive sleep apnea (OSA). There was no statistical significance noted in the any complication or death. There was no difference in weight loss over time between the two groups. The statin group was more likely to report resolution in HLD (27.5 vs 9.5%, P = 0.004), but not DM, HTN, or OSA. In summary, there are differences in bariatric patients who take statins compared with their counterparts. Statins with gastric bypass may improve resolution of HLD, which may eventually alter long-term cardiac risk in these patients.
authors.affiliation: Department of Surgery, Medical University of South Carolina, Charleston, South Carolina 29464, USA. perna@musc.edu
authors.forename: Mark
authors.initials: M
authors.lastname: Perna
authors.forename: Megan
authors.initials: M
authors.lastname: Baker
authors.forename: Thomas Karl
authors.initials: TK
authors.lastname: Byrne
authors.forename: Katherine
authors.initials: K
authors.lastname: Morgan
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000188:drug therapy* / Q000601:surgery*; D019990:Perioperative Care / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors