title: Alcohol consumption and the risk of endometrial cancer: a meta-analysis.
abstract: Epidemiologic findings are inconsistent concerning the association of endometrial cancer risk with alcohol consumption. Therefore, we conduct a meta-analysis of studies that assessed the association of alcohol consumption and the risk of endometrial cancer. A systematic literature search up to April 2010 was performed in MEDLINE and EMBASE, and study-specific risk estimates were pooled using a random-effects model. In the present study, six prospective and 14 case-control studies were included. Alcohol intake was not significantly associated with the risk of endometrial cancer among prospective studies (relative risk (RR): 1.04; 95% confidence interval (CI): 0.91-1.18) or among case-control studies (odds ratio (OR): 0.89; 95% CI: 0.76-1.05). However evidence from the results of our stratified analyses revealed that increased risk of endometrial cancer was associated with liquor consumption (RR: 1.22; 95% CI: 1.03-1.45) but null association with wine and beer consumption. In conclusion, alcohol consumption is not associated with the risk of endometrial cancer. Future studies should also examine whether the relation varies according to different type of alcoholic beverages.
authors.affiliation: Department of Pharmacy, the Affiliated Wuxi Hospital for Maternal and Child Health Care of Nanjing Medical University, Jiangsu 214002, China. qingminsun@gmail.com
authors.forename: Qingmin
authors.initials: Q
authors.lastname: Sun
authors.forename: Linlin
authors.initials: L
authors.lastname: Xu
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.forename: You
authors.initials: Y
authors.lastname: Wang
authors.forename: Yali
authors.initials: Y
authors.lastname: Jing
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects*; D000434:Alcoholic Beverages / Q000009:adverse effects; D001515:Beer / Q000009:adverse effects; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D016239:MEDLINE; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking; D014920:Wine / Q000009:adverse effects