title: Exercise training and cytokines in breast cancer survivors.
abstract: The purpose of this randomized controlled trial was to determine the effects of an 8-week (aerobic+strength) exercise training program (3 sessions/week) on the circulating cytokine levels of breast cancer survivors. We randomly allocated 16 female survivors of breast cancer (mean±SD age: 50±5 years) to an intervention or usual care (control) group (N=8 in each group). The intervention group followed an 8-week exercise program consisting of 3 sessions/week (session duration: 90 min). We measured the levels of the following cytokines before and after the intervention: beta-NGF, CTACK, eotaxin, FGF basic, G-CSF, gmCSFα, HGF, ICAM1, IFNα2, IFNγ, IL1α, IL1ß, IL1ra, IL2, IL2ra, IL3, IL4, IL6, IL7, IL8, IL9, IL10, IL12, IL13, IL15, IL16, IL17, IL18, IP10, LIF, MCS-F, MIP1α, MIP1β, MIF, MCP1, MCP3, MIG, PDGF bb, SCF, SCGFβ, SDF1α, TRAIL, TNFα, TNFβ, VCAM1, and VEGF. We only observed a significant interaction (group*time) effect for CTACK ( P=0.016), with mean values remaining stable in the intervention group but increasing over time in controls. The intervention program did not induce a significant decrease in the main breast cancer-related cytokines such as IL6 and IL8. A combined (aerobic+strength) 8-week exercise training intervention did not induce major changes in the basal cytokine levels of breast cancer survivors.
authors.affiliation: Hospital Infantil Universitario Niño Jesús, Oncologia, Madrid, Spain.
authors.forename: A M
authors.initials: AM
authors.lastname: Gómez
authors.forename: C
authors.initials: C
authors.lastname: Martínez
authors.forename: C
authors.initials: C
authors.lastname: Fiuza-Luces
authors.forename: F
authors.initials: F
authors.lastname: Herrero
authors.forename: M
authors.initials: M
authors.lastname: Pérez
authors.forename: L
authors.initials: L
authors.lastname: Madero
authors.forename: J R
authors.initials: JR
authors.lastname: Ruiz
authors.forename: A
authors.initials: A
authors.lastname: Lucia
authors.forename: M
authors.initials: M
authors.lastname: Ramírez
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000534:rehabilitation*; D016207:Cytokines / Q000378:metabolism*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008875:Middle Aged; D055070:Resistance Training / Q000379:methods; D017741:Survivors
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8