title: Synthesis and characterization of PVP-coated large core iron oxide nanoparticles as an MRI contrast agent.
abstract: The purpose of this study was to synthesize biocompatible polyvinylpyrrolidone (PVP)-coated iron oxide (PVP-IO) nanoparticles and to evaluate their efficacy as a magnetic resonance imaging (MRI) contrast agent. The PVP-IO nanoparticles were synthesized by a thermal decomposition method and characterized by x-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), and a superconducting quantum interface device (SQUID). The core size of the particles is about 8-10 nm and the overall size is around 20-30 nm. The measured r(2) (reciprocal of T(2) relaxation time) and r2∗ (reciprocal of T2∗ relaxation time) are 141.2 and 338.1 (s mM)(-1), respectively. The particles are highly soluble and stable in various buffers and in serum. The macrophage uptake of PVP-IO is comparable to that of Feridex as measured by a Prussian blue iron stain and phantom study. The signal intensity of a rabbit liver was effectively reduced after intravenous administration of PVP-IO. Therefore PVP-IO nanoparticles are potentially useful for T(2)-weighted MR imaging.
authors.affiliation: Molecular Imaging Program at Stanford (MIPS) and Bio-X Department of Radiology, Stanford University, 1201 Welch Rd P095, Stanford, CA 94305-5484, USA.
authors.forename: Ha-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Lee
authors.forename: Chenjie
authors.initials: C
authors.lastname: Xu
authors.forename: Jin
authors.initials: J
authors.lastname: Xie
authors.forename: Jin-Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.forename: Ai Leen
authors.initials: AL
authors.lastname: Koh
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Wang
authors.forename: Robert
authors.initials: R
authors.lastname: Sinclair
authors.forename: Shan X
authors.initials: SX
authors.lastname: Wang
authors.forename: Dwight G
authors.initials: DG
authors.lastname: Nishimura
authors.forename: Sandip
authors.initials: S
authors.lastname: Biswal
authors.forename: Shouheng
authors.initials: S
authors.lastname: Sun
authors.forename: Sun Hang
authors.initials: SH
authors.lastname: Cho
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen