title: Enantioselective pharmacokinetics of ketoprofen in piglets: the significance of neonatal age.
abstract: Following intravenous dose of 6mg/kg racemic ketoprofen, the chiral pharmacokinetics of ketoprofen was investigated in eight piglets aged 6 and 21days old. S-ketoprofen predominated over R-ketoprofen in plasma of the piglets in both age groups. The volumes of distribution of S-ketoprofen for the 6- and 21-day-old piglets were 241.7 (211.3-276.5) mL/kg and 155.0 (138.7-173.1) mL/kg, respectively, while the corresponding parameters for R-ketoprofen were 289.2 (250.3-334.2) mL/kg and 193.0 (168.7-220.8) mL/kg. The clearances of R-ketoprofen [948.4 (768.0-1171.2) mL/h/kg and 425 (319.1-566.0) mL/h/kg for the 6- and 21-day-old piglets, respectively] were significantly higher compared to the clearances of S-ketoprofen [57.3 (46.6-70.4) mL/h/kg and 33.8 (27.0-42.2) mL/h/kg for 6- and 21-day-old piglets, respectively]. The elimination half-life of S-ketoprofen was 3.4h for both age groups, while the elimination half-life of R-ketoprofen was 0.2h for the 6-day-old and 0.4h for the 21-day-old piglets. The clearances of both R- and S-ketoprofen were significantly higher in the 6-day-old piglets compared to when they were 21 days old. Furthermore, the volumes of distribution were larger in the youngest age group.
authors.affiliation: Department of Food Safety and Infection Biology, The Norwegian School of Veterinary Science, Oslo, Norway. torunn.fosse@nvh.no
authors.forename: T K
authors.initials: TK
authors.lastname: Fosse
authors.forename: T E
authors.initials: TE
authors.lastname: Horsberg
authors.forename: H A
authors.initials: HA
authors.lastname: Haga
authors.forename: V
authors.initials: V
authors.lastname: Hormazabal
authors.forename: B
authors.initials: B
authors.lastname: Ranheim
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000493:pharmacokinetics*; D019540:Area Under Curve; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D007660:Ketoprofen / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D013329:Structure-Activity Relationship; D013552:Swine / Q000378:metabolism*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen