title: Different distributions of hepatitis C virus genotypes among HIV-infected patients with acute and chronic hepatitis C according to interleukin-28B genotype.
abstract: OBJECTIVE
  The C allele of the single nucleotide polymorphism rs12979860, located near the interleukin-28B (IL-28B) gene, has a strong impact on hepatitis C virus (HCV) treatment response, as well as on spontaneous viral clearance. In patients with chronic hepatitis C (CHC), genotype CC carriers harbour HCV genotype 3 more commonly than those with non-CC genotypes. The aim of this study was to compare the HCV genotype distributions, according to IL-28B genotype, in HIV-infected patients with CHC and those with acute hepatitis C (AHC).
  
  
  METHODS
  The rs12979860 genotype was determined by polymerase chain reaction (PCR) in two subpopulations of HIV-infected patients. The first consisted of 80 German patients with AHC. The second consisted of 476 patients with CHC, belonging to one German and two Spanish cohorts.
  
  
  RESULTS
  In the AHC group, 31 (81.6%) rs12979860 CC carriers were infected with HCV genotype 1 or 4 vs. 32 (76.2%) among non-CC carriers (P=0.948). In patients with CHC, among those with the CC genotype, 119 (54.6%) were infected with HCV genotype 1 or 4 and 99 (45.4%) with genotype 2 or 3, whereas in the subset with non-CC genotypes, 200 (77.5%) harboured HCV genotype 1 or 4 and 58 (22.5%) genotype 2 or 3 (P<0.001).
  
  
  CONCLUSIONS
  Among HIV-infected patients with CHC, those bearing the IL-28B genotype CC were more commonly infected with genotype 3 than subjects with non-CC genotypes, whereas in HIV-infected subjects with AHC this finding was not obtained. These results strongly suggest that the protective effect of the CC genotype against evolution to CHC is mainly exerted in patients infected with HCV genotype 1 or 4.
authors.affiliation: Unit of Infectious Diseases, Valme University Hospital, Seville, Spain.
authors.forename: K
authors.initials: K
authors.lastname: Neukam
authors.forename: J
authors.initials: J
authors.lastname: Nattermann
authors.forename: N
authors.initials: N
authors.lastname: Rallón
authors.forename: A
authors.initials: A
authors.lastname: Rivero
authors.forename: A
authors.initials: A
authors.lastname: Caruz
authors.forename: J
authors.initials: J
authors.lastname: Macías
authors.forename: M
authors.initials: M
authors.lastname: Vogel
authors.forename: Jm
authors.initials: J
authors.lastname: Benito
authors.forename: A
authors.initials: A
authors.lastname: Camacho
authors.forename: Ja
authors.initials: J
authors.lastname: Mira
authors.forename: C
authors.initials: C
authors.lastname: Schwarze-Zander
authors.forename: P
authors.initials: P
authors.lastname: Barreiro
authors.forename: A
authors.initials: A
authors.lastname: Martínez
authors.forename: Jk
authors.initials: J
authors.lastname: Rockstroh
authors.forename: V
authors.initials: V
authors.lastname: Soriano
authors.forename: Ja
authors.initials: J
authors.lastname: Pineda
mesh_terms: D000328:Adult; D060085:Coinfection; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications / Q000821:virology; D016174:Hepacivirus / Q000145:classification / Q000235:genetics*; D006526:Hepatitis C / Q000150:complications / Q000235:genetics / Q000821:virology*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000235:genetics / Q000821:virology*; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda