title: Fecal calprotectin is a useful marker for disease activity in pediatric patients with inflammatory bowel disease.
abstract: BACKGROUND
  Studies evaluating the correlation between endoscopic disease activity and noninvasive markers are scarce in inflammatory bowel disease (IBD).
  
  
  OBJECTIVE
  The aim of this study is to evaluate the accuracy of the fecal calprotectin (FC) assay as a marker of disease activity of IBD, as determined by an extensive endoscopic scoring system.
  
  
  METHODS
  Thirty-five children and adolescents with IBD [17 with ulcerative colitis (UC) and 18 with Crohn's disease (CD)] and 28 healthy volunteers were enrolled. FC levels were determined by ELISA. The sum of Matts' score for UC and the simple endoscopic score for Crohn's disease (SES-CD) were used. The ileal lesions were evaluated by ultrasonography.
  
  
  RESULTS
  In UC patients, there was a strong correlation between FC levels and the sum of Matts' score (r=0.838, p<0.01). FC levels were significantly elevated in endoscopically active patients (median 1,562.5 μg/g) as compared to patients in endoscopic remission (median 38.9 μg/g) or healthy controls (median 19.9 μg/g). In CD patients, there was a strong correlation between FC levels and the SES-CD score (r=0.760, p<0.01). The FC levels were significantly higher in endoscopically active patients (median 2,037.5 μg/g) than in endoscopically inactive patients (median 172.5 μg/g) or healthy controls (median 19.9 μg/g), respectively. The FC levels of patients with ileal wall thickening (median 2,225.0 μg/g) were significantly higher than healthy controls (median 19.9 μg/g) and patients lacking ileal wall thickening (median 17.5 μg/g), respectively.
  
  
  CONCLUSIONS
  The FC assay is a useful marker for the detection of mucosal inflammation in pediatric IBD patients.
authors.affiliation: Department of Pediatrics, Osaka Medical College, Daigaku-Cho 2-7, Takatsuki, 569-8686, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Aomatsu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoden
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Emi
authors.initials: E
authors.lastname: Kimura
authors.forename: Keisuke
authors.initials: K
authors.lastname: Inoue
authors.forename: Akira
authors.initials: A
authors.lastname: Andoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamai
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D002648:Child; D016099:Endoscopy, Gastrointestinal; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D007413:Intestinal Mucosa / Q000648:ultrastructure; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D012720:Severity of Illness Index; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex