title: [Association between chicken A-FABP gene polymorphisms and growth and body composition traits].
abstract: This experiment was designed to study the effects of polymorphism of A-FABP gene on growth and body composition traits in chicken. The 10th generation broiler population, derived from the Northeast Agricultural University broiler lines divergently selected for abdominal fat content (NEAUHLF) was used. Polymorphism among individuals was detected by DNA sequencing, PCR-RFLP, PCR-LP, and DHPLC. Linkage disequilibrium analysis for eight SNPs was performed, and five htSNPs were selected to construct haplotypes. The association analysis between the individual SNPs and haplotypes and growth and body composition traits were investigated, respectively. The results showed that there were consistently significant effects on muscle stomach weight (MSW) and percentage of muscle stomach (MSW/BW) (Pamp;0.05) in the seven SNPs (except for SNP 5) and haplotypes, but no significant effect on any other trait (P>0.05). Due to no evidence on effects of A-FABP for digestion system in other species, future experiments need to be developed to confirm whether A-FABP could be a major gene of MSW and MSW/BW traits in broiler chicken.
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. wangqigui@hotmail.com
authors.forename: Qi-Gui
authors.initials: QG
authors.lastname: Wang
authors.forename: Tian-Zhu
authors.initials: TZ
authors.lastname: Guan
authors.forename: Shou-Zhi
authors.initials: SZ
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D001823:Body Composition; D001835:Body Weight; D002645:Chickens / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006239:Haplotypes; D009929:Organ Size; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D013270:Stomach / Q000254:growth & development*
chemical_list: D050556:Fatty Acid-Binding Proteins