title: Chronic myelogenous leukemia with mild basophilia as the predominant manifestation at presentation.
abstract: Chronic myelogenous leukemia (CML) is a clonal hematological malignancy typically presenting with basophilia and massive proliferation of differentiating myeloid cells. We report an atypical case of CML in which mild basophilia was the sole manifestation at presentation, and the condition persisted for 27 months with no sign of progression. This case reconfirms the importance of basophilia as a clinical manifestation of CML, and BCR-ABL FISH analysis should always be applied to cases of basophilia, even when the basophilia is modest and no other features of CML are present.
authors.affiliation: Division of Hematology, Department of Medicine, Juntendo University Nerima Hospital, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Yasuda
authors.forename: Nanae
authors.initials: N
authors.lastname: Aritaka
authors.forename: Jun
authors.initials: J
authors.lastname: Ando
authors.forename: Michihiro
authors.initials: M
authors.lastname: Hirama
authors.forename: Norio
authors.initials: N
authors.lastname: Komatsu
authors.forename: Takao
authors.initials: T
authors.lastname: Hirano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001491:Basophils / Q000473:pathology*; D001549:Benzamides; D007446:Chromosome Inversion; D002898:Chromosomes, Human, Pair 8; D016313:Genes, abl; D006801:Humans; D000068877:Imatinib Mesylate; D017404:In Situ Hybridization, Fluorescence; D015466:Leukemia, Myeloid, Chronic-Phase / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D008297:Male; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate