title: Assessment of tissue edema in patients with acute myocardial infarction by computer-assisted quantification of triple inversion recovery prepared MRI of the myocardium.
abstract: The aim of this study was to design a computer algorithm to assess the extent of cardiac edema from triple inversion recovery MR images of the human left ventricular myocardium. Twenty-one patients presenting with acute myocardial infarction were scanned within 48 h of the onset of symptoms. Eight patients were scanned a second time, 4 weeks after the initial event. Myocardial edema was detected in 27 of 29 studies using visual contour-based manual segmentation. A reference standard, created from the segmentations of three raters by voxel-wise majority voting, was compared to the edema mass estimates obtained using a newly developed computer algorithm. At baseline (n=20), the reference standard yielded an edema mass of 16.4±15.0 g (mean±SD) and the computer algorithm edema mass was 16.4±12.6 g. At follow-up (n=7), the reference standard edema mass was 7.1±4.4 g compared to 16.3±7.7 g at baseline. Computer algorithm estimates showed the same pattern of change with 5.7±5.7 g at follow-up compared to 20.8±13.8 g at baseline. Although there was a significant degree of discrepancy between reference standard and computer algorithm estimates of edema mass in individual patients, their overall agreement was good, with intraclass correlation coefficient ICC(3, 1)=0.753.
authors.affiliation: Department of Medical Physics and Engineering, Leeds Teaching Hospitals Trust, and School of Medicine, University of Leeds, Leeds, United Kingdom.
authors.forename: R I
authors.initials: RI
authors.lastname: Johnstone
authors.forename: J P
authors.initials: JP
authors.lastname: Greenwood
authors.forename: J D
authors.initials: JD
authors.lastname: Biglands
authors.forename: S
authors.initials: S
authors.lastname: Plein
authors.forename: J P
authors.initials: JP
authors.lastname: Ridgway
authors.forename: A
authors.initials: A
authors.lastname: Radjenovic
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D004487:Edema / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity