title: [Review of the target for the deep brain stimulation of chronic cluster headache].
abstract: Cluster headache is included in the group of trigeminal autonomic cephalalgias. Although the pathophysiology of cluster headache has not yet been sufficiently established, the theory of a central origin tells us that this headache is produced by hypothalamic dysfunction. More than 50 patients have been treated with deep brain stimulation of the posterior nucleus of the hypothalamus from 2001. The results show clinical improvement in more than 60% of the cases, opening a promising issue for the treatment of the cluster headache persistent after medical treatment. The surgical target that have been used until now is based on the origin of the cluster headache in the hypothalamic dysfunction. Nevertheless, It has still some open questions as the lack of proving the posterior nucleus of the hypothalamus is the real origin of the cluster headache, the lack of consensus about the anatomy of the surgical target and the variability of the structures stimulated with the surgery. The aim of this article is a review of the target used and propose another surgical target based on physiopathological concepts to explain the improvement with the deep brain stimulation in these patients.
authors.affiliation: Hospital Universitario Central de Asturias, 33006 Oviedo, Espana. fseijo@uniovi.es
authors.forename: F
authors.initials: F
authors.lastname: Seijo-Fernandez
authors.forename: E
authors.initials: E
authors.lastname: Seijo-Zazo
authors.forename: A
authors.initials: A
authors.lastname: Saiz-Ayala
authors.forename: E
authors.initials: E
authors.lastname: Santamarta-Liebana
authors.forename: M A
authors.initials: MA
authors.lastname: Alvarez-Vega
authors.forename: B
authors.initials: B
authors.lastname: Lozano-Aragoneses
authors.forename: J
authors.initials: J
authors.lastname: Sol
authors.forename: F
authors.initials: F
authors.lastname: Fernandez-Gonzalez
mesh_terms: D003027:Cluster Headache / Q000503:physiopathology / Q000628:therapy*; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D007034:Hypothalamus, Posterior / Q000033:anatomy & histology* / Q000503:physiopathology / Q000601:surgery*; D051303:Trigeminal Autonomic Cephalalgias / Q000503:physiopathology / Q000628:therapy