title: Unintentional weight loss as the sole indication for colonoscopy is rarely associated with colorectal cancer.
abstract: BACKGROUND
  Weight loss is a commonly used indication for colonoscopy.
  
  
  METHODS
  This is a prospective case study of colonoscopies from 1998 to 2009. Descriptive statistics were used to evaluate age, sex, colonoscopy indications, and findings. Multiple logistic regression analysis was used to determine the odds of colorectal cancer (CRC) based on age, sex, and weight loss.
  
  
  RESULTS
  We reviewed 6425 colonoscopies. The mean age of patients was 57.4 years (SD, ±13.5 years), and 55% of patients were women. One hundred thirty-six (2.1%) of these had unintentional weight loss; for 32 patients (0.4%), unintentional weight loss was the only indication for the procedure. CRC was diagnosed in 116 patients (1.8%), but CRC was not detected in any patients for whom unintentional weight loss as the only indication for colonoscopy.
  
  
  CONCLUSIONS
  Based on our prospective case study, unintentional weight loss alone was not associated with CRC.
authors.affiliation: Department of Internal Medicine, Medical College of Georgia-Georgia Health Sciences University, Augusta.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Davis
authors.forename: Shannon J
authors.initials: SJ
authors.lastname: Marek
authors.forename: Subbaramiah
authors.initials: S
authors.lastname: Sridhar
authors.forename: Thad
authors.initials: T
authors.lastname: Wilkins
authors.forename: Sherman M
authors.initials: SM
authors.lastname: Chamberlain
mesh_terms: D000328:Adult; D000368:Aged; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015431:Weight Loss