title: Psychiatric disorder in early adulthood and risk of premature mortality in the 1946 British Birth Cohort.
abstract: BACKGROUND
  Few studies of the association between psychiatric disorder and premature death have adjusted for key confounders and used structured psychiatric interviews. We aimed to investigate if psychiatric disorder was associated with a higher risk of mortality and whether any excess mortality was due to suicide, or explained by other health or socioeconomic risk factors.
  
  
  METHODS
  We used data from the MRC National Survey of Health and Development, a nationally representative UK birth cohort. 3283 men and women completed the Present State Examination at age 36. The main outcome measure was all-cause mortality before age 60.
  
  
  RESULTS
  Those with psychiatric disorder at age 36 had a higher risk of death even after adjusting for potential confounders (Hazard ratio = 1.84, 95% C.I. 1.22-2.78). Censoring violent deaths and suicides led to similar results.
  
  
  CONCLUSIONS
  Psychiatric disorder was associated with excess premature mortality not explained by suicide or other health or socioeconomic risk factors.
authors.affiliation: King's College London, Institute of Psychiatry, Department of Psychological Medicine, Weston Education Centre, Cutcombe Road, London SE5 9RJ UK. max.j.henderson@kcl.ac.uk
authors.forename: Max
authors.initials: M
authors.lastname: Henderson
authors.forename: Matthew
authors.initials: M
authors.lastname: Hotopf
authors.forename: Imran
authors.initials: I
authors.lastname: Shah
authors.forename: Richard D
authors.initials: RD
authors.lastname: Hayes
authors.forename: Diana
authors.initials: D
authors.lastname: Kuh
mesh_terms: D000328:Adult; D002423:Cause of Death; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D001523:Mental Disorders / Q000401:mortality* / Q000523:psychology; D008875:Middle Aged; D012306:Risk; D012737:Sex Factors; D012959:Socioeconomic Factors; D013405:Suicide / Q000706:statistics & numerical data*