title: [2+2] Cycloaddition of ketenes with ynamides. A general method for the synthesis of 3-aminocyclobutenone derivatives.
abstract: Ynamides react with ketenes in [2+2] cycloadditions leading to a variety of substituted 3-aminocyclobut-2-en-1-ones. The ynamides employed in these reactions are readily available via the copper-promoted N-alkynylation of carbamates and sulfonamides with alkynyl bromides and iodides. The scope of the [2+2] cycloaddition with regard to both the ketene and ynamide component is described.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Kohnen
authors.forename: Xiao Yin
authors.initials: XY
authors.lastname: Mak
authors.forename: Tin Yiu
authors.initials: TY
authors.lastname: Lam
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Dunetz
authors.forename: Rick L
authors.initials: RL
authors.lastname: Danheiser