title: Consumptive hypothyroidism: a case report and review of the literature.
abstract: Hepatic haemangioendothelioma is a rare vascular tumour in infants and may be associated with a unique form of thyroid function abnormalities. Hepatic haemangioendotheliomata is capable of producing an excess of the thyroid hormone inactivating enzyme, type 3 iodothyronine deiodinase. The increased enzyme activity leads to rapid degradation of thyroid hormones, resulting in frank hypothyroidism. We report a case of a three-month-old neonate with multiple hepatic haemangioendotheliomata and associated hypothyroidism. The patient required increasing doses of thyroid hormone.
authors.affiliation: Department of Clinical Biochemistry and Immunology, Leeds Teaching Hospitals Trust, Leeds LS13EX, UK. nuthar.jassam@hdtf.nhs.uk
authors.forename: N
authors.initials: N
authors.lastname: Jassam
authors.forename: T J
authors.initials: TJ
authors.lastname: Visser
authors.forename: T
authors.initials: T
authors.lastname: Brisco
authors.forename: D
authors.initials: D
authors.lastname: Bathia
authors.forename: P
authors.initials: P
authors.lastname: McClean
authors.forename: J H
authors.initials: JH
authors.lastname: Barth
mesh_terms: D005260:Female; D006390:Hemangioendothelioma / Q000150:complications*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013960:Thyroid Function Tests; D055815:Young Adult