title: Hydrogen peroxide as a signaling molecule.
abstract: Increases in hydrogen peroxide can initiate protective responses to limit or repair oxidative damage. However, hydrogen peroxide signals also fine-tune responses to growth factors and cytokines to control cell division, differentiation, and migration. Here we discuss some of the mechanisms by which hydrogen peroxide is sensed and utilized as a signaling molecule to regulate diverse biological processes. We also discuss how the localization and levels of hydrogen peroxide, antioxidants, and the cellular metal composition together influence the nature of the response.
authors.affiliation: Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom. e.a.veal@ncl.ac.uk
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Veal
authors.forename: Alison
authors.initials: A
authors.lastname: Day
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D000975:Antioxidants; D006861:Hydrogen Peroxide