title: How important are Rho GTPases in neurosecretion?
abstract: Rho GTPases are small GTP binding proteins belonging to the Ras superfamily which act as molecular switches that regulate many cellular function including cell morphology, cell to cell interaction, cell migration and adhesion. In neuronal cells, Rho GTPases have been proposed to regulate neuronal development and synaptic plasticity. However, the role of Rho GTPases in neurosecretion is poorly documented. In this review, we discuss data that highlight the importance of Rho GTPases and their regulators into the control of neurotransmitter and hormone release in neurons and neuroendocrine cells, respectively.
authors.affiliation: CNRS UPR 3212, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Strasbourg, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Momboisse
authors.forename: Sébastien
authors.initials: S
authors.lastname: Houy
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ory
authors.forename: Valérie
authors.initials: V
authors.lastname: Calco
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Bader
authors.forename: Stéphane
authors.initials: S
authors.lastname: Gasman
mesh_terms: D000818:Animals; D002838:Chromaffin System / Q000502:physiology; D006801:Humans; D009489:Neurosecretion / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology; D016716:PC12 Cells; D051381:Rats; D009435:Synaptic Transmission / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents; D020741:rho GTP-Binding Proteins