title: Meropenem/clavulanate and linezolid treatment for extensively drug-resistant tuberculosis.
abstract: The combination of meropenem with clavulanate has high antimycobacterial activity in vitro against extensively drug-resistant Mycobacterium tuberculosis strains. We report the successful use of this combination in association with linezolid in the management of an advanced extensively drug-resistant tuberculosis disease with complex second-line drug resistance in a 14-year-old teenager.
authors.affiliation: Division of Infectious Diseases, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dauby
authors.forename: Inge
authors.initials: I
authors.lastname: Muylle
authors.forename: Françoise
authors.initials: F
authors.lastname: Mouchet
authors.forename: Roger
authors.initials: R
authors.lastname: Sergysels
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Payen
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D019818:Clavulanic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D054908:Extensively Drug-Resistant Tuberculosis / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000069349:Linezolid; D000077731:Meropenem; D023303:Oxazolidinones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013845:Thienamycins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D000995:Antitubercular Agents; D023303:Oxazolidinones; D013845:Thienamycins; D019818:Clavulanic Acid; D000077731:Meropenem; D000069349:Linezolid