title: Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.
abstract: α-Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively. Incubation of 1 with C. gloeosporioides (EYL131) gave four metabolites which were identified as mangostin 3-sulfate (2), mangostanin 6-sulfate (3), 17,18-dihydroxymangostanin 6-sulfate (4)and isomangostanin 3-sulfate (5). Compound 2 was also formed by incubation with N. spathulata (EYR042). The structures of the isolated compounds were elucidated by spectroscopic data analysis. Of the isolated metabolites, 2 exhibited significant anti-mycobacterial activity against Mycobacterium tuberculosis.
authors.affiliation: Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand. panarata@swu.ac.th
authors.forename: Panarat
authors.initials: P
authors.lastname: Arunrattiyakorn
authors.forename: Sunit
authors.initials: S
authors.lastname: Suksamrarn
authors.forename: Nuttika
authors.initials: N
authors.lastname: Suwannasai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanzaki
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism*; D029762:Garcinia mangostana / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013237:Stereoisomerism; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D044004:Xanthones; C021053:mangostin