title: Oculogyric crises secondary to lamotrigine overdosage.
abstract: We report four patients with no preexisting movement disorders who developed oculogyric crises secondary to lamotrigine toxicity and had resolution of these crises after dose reduction. Episode numbers ranged from 1-20 per day and episode duration from 2 s to several hours. Mean plasma concentration of lamotrigine at the time of oculogyric crisis was 15.5 μg/mL, with a mean dose of 16 mg/kg per day.
authors.affiliation: Division of Pediatric Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Aravindhan
authors.initials: A
authors.lastname: Veerapandiyan
authors.forename: William B
authors.initials: WB
authors.lastname: Gallentine
authors.forename: Sara A
authors.initials: SA
authors.lastname: Winchester
authors.forename: John
authors.initials: J
authors.lastname: Baker
authors.forename: Sujay M
authors.initials: SM
authors.lastname: Kansagra
authors.forename: Mohamad A
authors.initials: MA
authors.lastname: Mikati
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000097:blood / Q000150:complications*; D004359:Drug Therapy, Combination; D020821:Dystonic Disorders / Q000139:chemically induced*; D004832:Epilepsy, Absence / Q000188:drug therapy*; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D015835:Ocular Motility Disorders / Q000139:chemically induced*; D012189:Retrospective Studies; D014227:Triazines / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine