title: Depressive symptoms and physical performance in the lifestyle interventions and independence for elders pilot study.
abstract: OBJECTIVE
  To determine whether the presence of high depressive symptoms (Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 14) diminished physical performance benefits after a comprehensive physical activity intervention in older adults.
  
  
  METHODS
  A post hoc analysis of data from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study, a single-blind randomized controlled trial comparing a moderate-intensity physical activity intervention (PA) with a successful aging control (SA).
  
  
  METHODS
  Multicenter U.S. institutions participating in the LIFE-P trial.
  
  
  METHODS
  Four hundred twenty-four sedentary, noninstitutionalized adults aged 70 to 89.
  
  
  METHODS
  Depressive symptoms were assessed using the CES-D. Physical performance tests included the Short Physical Performance Battery (SPPB) and 400-m walk time (400 mw) at baseline and 6 and 12 months.
  
  
  RESULTS
  Of the participants, 15.8% had high depressive symptom scores (CES-D ≥ 14). For participants with low depressive symptoms, SPPB scores improved more in the PA than the SA group over 12 months (adjusted score difference +0.70; P < .001 at 6 months and +0.58; P = .004 at 12 months), and 400 mw times improved in the PA group at 6 months (adjusted score difference -0.41 minutes; P = .02). For participants with high depressive symptoms, the difference in improvement fell short of statistical significance on the SPPB between the PA and SA groups (adjusted score difference +0.76 (P = .18) at 6 months and +0.94 (P = .12) at 12 months).
  
  
  CONCLUSIONS
  The presence of high depressive symptoms did not substantially diminish physical performance benefits realized after a PA intervention in sedentary older adults.
authors.affiliation: Division of Geriatrics, School of Medicine, University of South Carolina, Columbia, South Carolina, USA. Margaret.Matthews@palmettohealth.org
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Matthews
authors.forename: Fang-Chi
authors.initials: FC
authors.lastname: Hsu
authors.forename: Michael P
authors.initials: MP
authors.lastname: Walkup
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Barry
authors.forename: Kushang V
authors.initials: KV
authors.lastname: Patel
authors.forename: Steven N
authors.initials: SN
authors.lastname: Blair
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D003863:Depression / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control*; D005081:Exercise Therapy; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D010865:Pilot Projects; D057185:Sedentary Behavior; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology