title: Nasopharyngeal carcinoma detected by narrow-band imaging endoscopy.
abstract: The aim of the study was to investigate the novel endoscopic findings in nasopharyngeal carcinoma (NPC) under narrow-band imaging (NBI) and to determine the reliability of screening NPC by NBI. A total of 79 adults underwent nasopharyngeal biopsy. We proposed five distinctly different findings that need to be examined by NBI: Type I: brownish spots, Type II: irregular microvascular pattern (IMVP), Type III: light crests, Type IV: side-difference, Type V: presence of either IMVP or side-difference, of which last three (Type III-V) were a new concept. The results of NPC diagnosis by detecting NBI Type V pattern, the false positive, false negative, sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 6.7%, 2.9%, 97.1%, 93.3%, 91.7%, 97.7%, and 94.9%, respectively. On the other hand, there was a higher prevalence of Type I and IV patterns in T1 category NPC. The nasopharyngeal endoscopy coupled with NBI was able to provide a rapid, convenient, and highly reliable screening for high-risk populations.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital at Chiayi, Graduate Institute of Clinical Medical Sciences, Chang Gung University, College of Medicine, No. 6 West Section, Chia-Pu Road, Pu-Tzu City, Chiayi County 613, Taiwan. ent.taiwan@gmail.com
authors.forename: Wen-Hung
authors.initials: WH
authors.lastname: Wang
authors.forename: Yen-Chun
authors.initials: YC
authors.lastname: Lin
authors.forename: Kam-Fai
authors.initials: KF
authors.lastname: Lee
authors.forename: Hsu-Huei
authors.initials: HH
authors.lastname: Weng
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008027:Light; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis*; D009305:Nasopharynx / Q000473:pathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity