title: Gene expression profiles in peripheral blood for the diagnosis of autoimmune diseases.
abstract: Gene expression profiling in clinical genomics has yet to deliver robust and reliable approaches for developing diagnostics and contributing to personalized medicine. Owing to technological developments and the recent accumulation of expression profiles, it is a timely and relevant question whether peripheral blood gene expression profiling can be used routinely in clinical decision making. Here, we review the available gene expression profiling data of peripheral blood in autoimmune and chronic inflammatory diseases and suggest that peripheral blood mononuclear cells are suitable for descriptive and comparative gene expression analyses. A gene-disease interaction network in chronic inflammatory diseases, a general protocol for future studies and a decision tree for researchers are presented to facilitate standardization and adoption of this approach.
authors.affiliation: Department of Biochemistry and Molecular Biology, Research Center for Molecular Mediicne, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
authors.forename: Bertalan
authors.initials: B
authors.lastname: Mesko
authors.forename: Szilard
authors.initials: S
authors.lastname: Poliska
authors.forename: Laszlo
authors.initials: L
authors.lastname: Nagy
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D002908:Chronic Disease; D019295:Computational Biology / Q000379:methods; D015870:Gene Expression; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D046228:Microarray Analysis