title: Reduction in fluoride-induced genotoxicity in mouse bone marrow cells after substituting high fluoride-containing water with safe drinking water.
abstract: Treatment of mice with 15 mg l(-1) sodium fluoride (NaF) for 30 days increased the number of cell death, chromosomal aberrations (CAs) and 'cells with chromatid breaks' (aberrant cells) compared with control. The present study was intended to determine whether the fluoride (F)-induced genotoxicity could be reduced by substituting high F-containing water after 30 days with safe drinking water, containing 0.1 mg F ions l(-1). A significant fall in percentage of CAs and aberrant cells after withdrawal of F-treatment following 30 days of safe water treatment in mice was observed which was highest after 90 days, although their levels still remained significantly high compared with the control group. This observation suggests that F-induced genotoxicity could be reduced by substituting high F-containing water with safe drinking water. Further study is warranted with different doses and extended treatment of safe water to determine whether the induced damages could be completely reduced or not.
authors.affiliation: Radiation Genetics and Chemical Mutagenesis Laboratory, Department of Zoology, Centre for Advanced Studies, Visva-Bharati University, Santiniketan-731235, West Bengal, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Podder
authors.forename: Ansuman
authors.initials: A
authors.lastname: Chattopadhyay
authors.forename: Shelley
authors.initials: S
authors.lastname: Bhattacharya
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D002869:Chromosome Aberrations / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects*; D060766:Drinking Water / Q000737:chemistry*; D008297:Male; D051379:Mice; D012969:Sodium Fluoride / Q000633:toxicity*; D014874:Water Pollutants, Chemical
chemical_list: D060766:Drinking Water; D014874:Water Pollutants, Chemical; D012969:Sodium Fluoride