title: A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury.
abstract: We describe a novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that β-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat.
authors.affiliation: Department of Surgery, Second Hospital of HeBei Medical University, Shijiazhuang 050000, PR China. biwei8115@sohu.com
authors.forename: Wei
authors.initials: W
authors.lastname: Bi
authors.forename: Yue
authors.initials: Y
authors.lastname: Bi
authors.forename: Ping
authors.initials: P
authors.lastname: Xue
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Wang
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Michèle
authors.initials: M
authors.lastname: Baudy-Floc'h
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Ngerebara
authors.forename: K Michael
authors.initials: KM
authors.lastname: Gibson
authors.forename: Lanrong
authors.initials: L
authors.lastname: Bi
mesh_terms: D000208:Acute Disease; D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002243:Carbolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D005121:Extremities / Q000098:blood supply* / Q000473:pathology; D016166:Free Radical Scavengers / Q000378:metabolism; D007511:Ischemia / Q000188:drug therapy* / Q000473:pathology; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure; D016716:PC12 Cells; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D002243:Carbolines; D016166:Free Radical Scavengers; D010455:Peptides