title: Anti-arthritic active fraction of Capparis spinosa L. fruits and its chemical constituents.
abstract: The aim of this study was to ascertain the anti-arthritic active fraction of Capparis spinosa L. (Capparidaceae) fruits and its chemical constituents. The adjuvant arthritic rat model was developed to evaluate the anti-arthritic effects of different fractions of ethanol extraction from C. spinosa L. The fraction eluted by ethanol-water (50:50, v/v) had the most significant anti-arthritic activity. The chemical constituents of this fraction were therefore studied; seven known compounds were isolated and identified as: P-hydroxy benzoic acid; 5-(hydroxymethyl) furfural; bis(5-formylfurfuryl) ether; daucosterol; α-D-fructofuranosides methyl; uracil; and stachydrine.
authors.affiliation: Plant Biotechnology Research Center, School of Agriculture and Biology, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, Shanghai Jiao Tong University, China.
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Feng
authors.forename: Jincai
authors.initials: J
authors.lastname: Lu
authors.forename: Hailiang
authors.initials: H
authors.lastname: Xin
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Wang
authors.forename: Kexuan
authors.initials: K
authors.lastname: Tang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D031484:Capparis / Q000737:chemistry*; D004195:Disease Models, Animal; D000431:Ethanol; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*; D011392:Proline / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014867:Water
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D014867:Water; D000431:Ethanol; D011392:Proline; C003342:stachydrine