title: [Acquired hemophilia A with rectus abdominis muscle and intrapelvic hematomas after aortic arch replacement].
abstract: A 60-year-old man demonstrated a bleeding tendency at enterostomy about 7 months after aortic arch replacement. Abdominal muscle hematoma and pelvic hematoma were also detected. He was diagnosed as having acquired hemophilia A based on prolonged APTT (65.9 sec), reduced FVIII activity (>1%), and the presence of FVIII inhibitor (19.5 BU/ml). Severe anemia was recognized. Recombinant activated factor FVIII (9.6 mg) was administered 25 times, combined with steroid pulse therapy. Usually postoperative acquired hemophilia is recognized in the immediate postoperative period or about 3 months later, while in this case, acquired hemophilia appeared 7 months postoperatively.
authors.affiliation: Department of Hematology, Juntendo University Shizuoka Hospital.
authors.forename: Mariko
authors.initials: M
authors.lastname: Ushiki
authors.forename: Michiaki
authors.initials: M
authors.lastname: Koike
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Akiyama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Watanabe
authors.forename: Hiroki
authors.initials: H
authors.lastname: Koyasu
authors.forename: Daijyu
authors.initials: D
authors.lastname: Mituhashi
authors.forename: Youko
authors.initials: Y
authors.lastname: Okawada
authors.forename: Shinn
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Yukio
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Syougo
authors.initials: S
authors.lastname: Sobue
authors.forename: Naoto
authors.initials: N
authors.lastname: Itou
authors.forename: Keiji
authors.initials: K
authors.lastname: Sugimoto
mesh_terms: D001013:Aorta, Thoracic / Q000601:surgery*; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation; D004766:Enterostomy; D005169:Factor VIII / Q000008:administration & dosage; D006406:Hematoma / Q000628:therapy; D006467:Hemophilia A / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D010388:Pelvis; D011183:Postoperative Complications; D020551:Pulse Therapy, Drug; D011994:Recombinant Proteins / Q000008:administration & dosage; D017568:Rectus Abdominis; D013997:Time Factors
chemical_list: D011994:Recombinant Proteins; D005169:Factor VIII; D008775:Methylprednisolone