title: [Frailty and dependence in Albacete (FRADEA study): reasoning, design and methodology].
abstract: OBJECTIVE
  To obtain a cohort of subjects of equal to or greater than 70 years, representative of a Spanish urban population, to estimate the prevalence of frailty and follow it up over time to analyse associated factors.
  
  
  METHODS
  A prospective, population-based cohort study. From a population of 18,137 elderly persons, a representative sample of 1172 was randomly stratified, of which 993 (84.7%) agreed to take part. The variables collected were; sociodemographic, comorbidity, functional (n=825), cognitive, affective and quality of life. On the patients who agreed, body composition was determined by bioimpedance analysis (n=557), basal metabolic rate by indirect calorimetry (n=450) and a blood sample was obtained for biomarkers (n=859). Frailty was defined by the presence of 3 or more Fried criteria: unintentional weight loss, low energy, exhaustion, slow walking, and low physical activity. The cohort will be followed up over time until the death of the subjects.
  
  
  RESULTS
  Mean age 79.4 (SD 6.4) years, with 601 (60.5%) women. A total of 21.3% were institutionalised; 16.9% were frail, 48.5% pre-frail, 21.3% non-frail, and 12.8% did not have the 3 criteria to be able to determine their state, of which 9.5% had moderate-severe incapacity, which would increase the prevalence of frailty to 26.4%.
  
  
  CONCLUSIONS
  A FRADEA cohort has been constructed, representative of an urban population in Spain. The prevalence of frailty in the cohort was 16.9%.
authors.affiliation: Sección de Geriatría, Complejo Hospitalario Universitario de Albacete, Albacete, España. pabizanda@sescam.jccm.es
authors.forename: Pedro
authors.initials: P
authors.lastname: Abizanda Soler
authors.forename: Jesús
authors.initials: J
authors.lastname: López-Torres Hidalgo
authors.forename: Luis
authors.initials: L
authors.lastname: Romero Rizos
authors.forename: Mercedes
authors.initials: M
authors.lastname: López Jiménez
authors.forename: Pedro Manuel
authors.initials: PM
authors.lastname: Sánchez Jurado
authors.forename: Pilar
authors.initials: P
authors.lastname: Atienzar Núñez
authors.forename: José Luis
authors.initials: JL
authors.lastname: Esquinas Requena
authors.forename: Inmaculada
authors.initials: I
authors.lastname: García Nogueras
authors.forename: Pablo
authors.initials: P
authors.lastname: Hernández Zegarra
authors.forename: Yadira
authors.initials: Y
authors.lastname: Bardales Mas
authors.forename: Ramona
authors.initials: R
authors.lastname: Campos Rosa
authors.forename: Mercedes
authors.initials: M
authors.lastname: Martínez Peñalver
authors.forename: Esther
authors.initials: E
authors.lastname: de la Osa Nieto
authors.forename: Miriam
authors.initials: M
authors.lastname: Carión González
authors.forename: Angela
authors.initials: A
authors.lastname: Ruiz Gómez
authors.forename: Caridad
authors.initials: C
authors.lastname: Aguilar Cantos
authors.forename: Pilar
authors.initials: P
authors.lastname: Mañueco Delicado
authors.forename: José Luis
authors.initials: JL
authors.lastname: Oliver Carbonell
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016330:Frail Elderly / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013030:Spain