title: Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase.
abstract: Metabolism of glucose through the pentose phosphate pathway (PPP) influences the development of diverse pathologies. Hemolytic anemia due to deficiency of PPP enzyme glucose 6-phosphate dehydrogenase is the most common genetic disease in humans. Recently, inactivation of another PPP enzyme, transaldolase (TAL), has been implicated in male infertility and fatty liver progressing to steatohepatitis and cancer. Hepatocarcinogenesis was associated with activation of aldose reductase and redox-sensitive transcription factors and prevented by N-acetylcysteine. In this paper, we discuss how alternative formulations of the PPP with and without TAL reflect cell type-specific metabolic control of oxidative stress, a crucial source of inflammation and carcinogenesis. Ongoing studies of TAL deficiency will identify new molecular targets for diagnosis and treatment in clinical practice.
authors.affiliation: Department of Medicine, State University of New York Upstate Medical University, College of Medicine, 750 East Adams Street, Syracuse, NY 13210, USA. perla@upstate.edu
authors.forename: Andras
authors.initials: A
authors.lastname: Perl
authors.forename: Robert
authors.initials: R
authors.lastname: Hanczko
authors.forename: Tiffany
authors.initials: T
authors.lastname: Telarico
authors.forename: Zachary
authors.initials: Z
authors.lastname: Oaks
authors.forename: Steve
authors.initials: S
authors.lastname: Landas
mesh_terms: D000111:Acetylcysteine / Q000378:metabolism; D000818:Animals; D015551:Autoimmunity; D006528:Carcinoma, Hepatocellular / Q000201:enzymology / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D005234:Fatty Liver / Q000473:pathology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000503:physiopathology; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000473:pathology; D018384:Oxidative Stress; D010427:Pentose Phosphate Pathway; D013081:Sperm Motility; D014153:Transaldolase / Q000172:deficiency / Q000378:metabolism*
chemical_list: D014153:Transaldolase; D005947:Glucose; D000111:Acetylcysteine