title: Sequential one-pot ruthenium-catalyzed azide-alkyne cycloaddition from primary alkyl halides and sodium azide.
abstract: An experimentally simple sequential one-pot RuAAC reaction, affording 1,5-disubstituted 1H-1,2,3-triazoles in good to excellent yields starting from an alkyl halide, sodium azide, and an alkyne, is reported. The organic azide is formed in situ by treating the primary alkyl halide with sodium azide in DMA under microwave heating. Subsequent addition of [RuClCp*(PPh(3))(2)] and the alkyne yielded the desired cycloaddition product after further microwave irradiation.
authors.affiliation: Division of Chemistry and Biochemistry, Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden. johan.johansson@chalmers.se
authors.forename: Johan R
authors.initials: JR
authors.lastname: Johansson
authors.forename: Per
authors.initials: P
authors.lastname: Lincoln
authors.forename: Bengt
authors.initials: B
authors.lastname: Nordén
authors.forename: Nina
authors.initials: N
authors.lastname: Kann
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry*; D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D019810:Sodium Azide / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D006846:Hydrocarbons, Halogenated; D019810:Sodium Azide