title: 1 H-MR spectroscopy in ultra-high risk and first episode stages of schizophrenia.
abstract: Using proton magnetic resonance spectroscopy biochemical characteristics in early stages of schizophrenia were examined. N-acetylaspartate, choline and creatine were measured in hippocampus, anterior cingulate gyrus (ACC) and medial prefrontal cortex (mPFC) of 24 first episode and 30 ultra-high risk patients. Careful LCModel analyses revealed no differences between the patient groups and 31 healthy controls, casting doubt upon the idea of metabolic changes in early stages of psychosis.
authors.affiliation: Dept. of Psychiatry, Ruhr-University Bochum, LWL University Hospital Bochum, Alexandrinenstrasse 1, 44791 Bochum, Germany. idun.uhl@wkp-lwl.org
authors.forename: Idun
authors.initials: I
authors.lastname: Uhl
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Mavrogiorgou
authors.forename: Christine
authors.initials: C
authors.lastname: Norra
authors.forename: Frank
authors.initials: F
authors.lastname: Forstreuter
authors.forename: Michael
authors.initials: M
authors.lastname: Scheel
authors.forename: Henning
authors.initials: H
authors.lastname: Witthaus
authors.forename: Seza
authors.initials: S
authors.lastname: Ozgürdal
authors.forename: Yehonala
authors.initials: Y
authors.lastname: Gudlowski
authors.forename: Georg
authors.initials: G
authors.lastname: Bohner
authors.forename: Jürgen
authors.initials: J
authors.lastname: Gallinat
authors.forename: Randolf
authors.initials: R
authors.lastname: Klingebiel
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
authors.forename: Georg
authors.initials: G
authors.lastname: Juckel
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001931:Brain Mapping; D016009:Chi-Square Distribution; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D011522:Protons; D012559:Schizophrenia / Q000175:diagnosis* / Q000378:metabolism*; D055815:Young Adult
chemical_list: D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline