title: Hypoxia. 5. Hypoxia and hematopoiesis.
abstract: Our understanding of organismal responses to hypoxia has stemmed from studies of erythropoietin regulation by hypoxia that led to the discovery of the master regulator of the hypoxic response, i.e., hypoxia-inducible factor (HIF). This is a transcription factor that is now known to induce the expression of a battery of genes in response to hypoxia. HIF-1 and HIF-2 regulate many genes that are involved in erythropoiesis and iron metabolism, which are essential for tissue oxygen delivery.
authors.affiliation: Hematology Division, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA.
authors.forename: Donghoon
authors.initials: D
authors.lastname: Yoon
authors.forename: Prem
authors.initials: P
authors.lastname: Ponka
authors.forename: Josef T
authors.initials: JT
authors.lastname: Prchal
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D015687:Cell Hypoxia / Q000502:physiology*; D019070:Cell Lineage; D004921:Erythropoietin / Q000378:metabolism; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000502:physiology; D020033:Protein Isoforms / Q000378:metabolism; D013577:Syndrome; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004921:Erythropoietin; D051793:Hypoxia-Inducible Factor 1; D007501:Iron; D010100:Oxygen; D020033:Protein Isoforms; D000099162:Endothelial PAS Domain-Containing Protein 1