title: [A case of AFP-producing gastric cancer resected after efficient S-1/CDDP combination chemotherapy].
abstract: A 62-year-old male was diagnosed as AFP-producing gastric cancer with lymph node metastases and multiple liver metastases. He was treated with S-1 and CDDP combination chemotherapy. At the end of the first course, both primary and metastatic lesions were remarkably decreased in size, and the serum AFP level was also decreased. The chemotherapy was effective against the cancer and led to a partial response (PR) according to the RECIST guideline. Following the nine months of PR, the primary lesion which had once nearly disappeared, emerged again. Because distant lymph node metastases and liver metastases were considered to have disappeared, distal gastrectomy with D2 lymphadenectomy was performed. The patient received S-1 monotherapy for 6 months after the operation. At present the patient has achieved progression-free survival for 1 year and 3 months after the operation. Though AFP-producing gastric cancer is known for its poor prognosis, combination treatment such as operation or hepatic arterial infusion chemotherapy may improve the prognosis in patients with advanced AFP-producing gastric cancer when systemic chemotherapy is effective.
authors.affiliation: Dept. of Gastroenterology and Hepatology, Kansai Electric Power Hospital, Japan.
authors.forename: Mikihiro
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Naoya
authors.initials: N
authors.lastname: Inoue
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Someda
authors.forename: Makiko
authors.initials: M
authors.lastname: Noguchi
authors.forename: Muneo
authors.initials: M
authors.lastname: Sawada
authors.forename: Keishiro
authors.initials: K
authors.lastname: Azuma
authors.forename: Aki
authors.initials: A
authors.lastname: Adachi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kuriyama
authors.forename: Suguru
authors.initials: S
authors.lastname: Uose
authors.forename: Takefumi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D004338:Drug Combinations; D000509:alpha-Fetoproteins; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin