title: Depletion study of three formulations of flumequine in edible tissues and drug transfer into chicken feathers.
abstract: To ensure the delivery of safe animal products to consumers, withdrawal times (WDT) of drugs must be respected. Drugs administered in therapies can also reach nonedible tissues (for humans) such as feathers; this transfer is of concern as feather meal is used in diets of food producing animals, being this a possible source of residue contamination of final products for human consumption. WDTs of three flumequine formulations (10%, 80% premix powder and 20% solution) as well as the transfer of this drug into feathers were determined. One hundred and twenty broiler chickens were allocated into four experimental groups (36 birds each). Three of them were treated with 24 mg/kg bw orally for five consecutive days of each flumequine formulation, whereas one group remained untreated (12 birds as control group). After the treatment ended, six chickens of each experimental group and two controls were slaughtered daily for 6 days. Samples of muscle, liver and feathers were collected and analyzed by liquid chromatography tandem mass spectrometry (LC MS/MS). The WDTs showed differences between formulations. Flumequine concentrations found in feathers remained high during WDT and after this period, thus suggesting that the WDTs estimated for the pharmaceutical formulation of flumequine do not guarantee the absence of this drug in chicken nonedible tissues such as feathers.
authors.affiliation: Laboratory of Veterinary Pharmacology, Faculty of Veterinary Sciences, Universidad de Chile, Santiago, Chile.
authors.forename: J
authors.initials: J
authors.lastname: Cornejo
authors.forename: L
authors.initials: L
authors.lastname: Lapierre
authors.forename: D
authors.initials: D
authors.lastname: Iragüen
authors.forename: N
authors.initials: N
authors.lastname: Pizarro
authors.forename: H
authors.initials: H
authors.lastname: Hidalgo
authors.forename: B San
authors.initials: BS
authors.lastname: Martín
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002645:Chickens / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004350:Drug Residues / Q000032:analysis*; D005241:Feathers / Q000737:chemistry* / Q000378:metabolism; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism; D011897:Random Allocation; D014018:Tissue Distribution
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C012976:flumequine