title: Polymorphism in a microsatellite of the acrp30 gene and its association with growth traits in goats.
abstract: Acrp30 plays a critical role in the regulation of glucose and lipid homeostasis. In this study, polymorphism of the Acrp30 gene was detected by PCR-SSCP and DNA sequencing methods in 321 individuals from three goat breeds, and the association of Acrp30 gene polymorphism with growth traits in the three goat breeds was analyzed. A novel insert/deletion (GT)(5) microsatellite sequence was detected in the 5' flanking region of the gene. Three genotypes (AA, AB, and BB) were found in three breeds. There was moderate genetic diversity in the locus in the analyzed populations. Significant associations were observed between the genotypes of the locus and growth traits in the Boer goat population. The chest circumference of individuals with genotype BB was significantly greater than that of individuals with genotype AA.
authors.affiliation: Institute of Cellular and Molecular Biology, College of Life Science, Xuzhou Normal University, China.
authors.forename: Xingtang
authors.initials: X
authors.lastname: Fang
authors.forename: Yu
authors.initials: Y
authors.lastname: Du
authors.forename: Chunlei
authors.initials: C
authors.lastname: Zhang
authors.forename: Xiuying
authors.initials: X
authors.lastname: Shi
authors.forename: Danxia
authors.initials: D
authors.lastname: Chen
authors.forename: Jiajie
authors.initials: J
authors.lastname: Sun
authors.forename: Qijiang
authors.initials: Q
authors.lastname: Jin
authors.forename: Xianyong
authors.initials: X
authors.lastname: Lan
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D024506:5' Flanking Region / Q000235:genetics; D052242:Adiponectin / Q000235:genetics* / Q000502:physiology; D000818:Animals; D005787:Gene Frequency; D056726:Genetic Association Studies; D014644:Genetic Variation; D006041:Goats / Q000235:genetics / Q000254:growth & development*; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018807:Polymorphism, Single-Stranded Conformational; D011401:Promoter Regions, Genetic
chemical_list: D052242:Adiponectin