title: A new device for rapid isolation by size and characterization of rare circulating tumor cells.
abstract: BACKGROUND
  Circulating tumor cells (CTCs) likely derive from clones in the primary tumor, suggesting that they can be used for all biological tests applying to the primary cells.
  
  
  METHODS
  The ScreenCell® devices are single-use and low-cost innovative devices that use a filter to isolate and sort tumor cells by size.
  
  
  RESULTS
  The ScreenCell® Cyto device is able to isolate rare, fixed, tumor cells, with a high recovery rate. Cells are well preserved morphologically. Immunocytochemistry and FISH assays can be performed directly on the filter. The ScreenCell® CC device allows isolation of live cells able to grow in culture. High quality genetic materials can be obtained directly from tumor cells isolated on the ScreenCell® MB device filter.
  
  
  CONCLUSIONS
  Due to their reduced size, versatility, and capacity to isolate CTCs within minutes, the ScreenCell® devices may be able to simplify and improve non-invasive access to tumor cells.
authors.affiliation: ScreenCell, 75012 Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Desitter
authors.forename: Bella S
authors.initials: BS
authors.lastname: Guerrouahen
authors.forename: Naoual
authors.initials: N
authors.lastname: Benali-Furet
authors.forename: Janine
authors.initials: J
authors.lastname: Wechsler
authors.forename: Pasi A
authors.initials: PA
authors.lastname: Jänne
authors.forename: Yanan
authors.initials: Y
authors.lastname: Kuang
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yanagita
authors.forename: Lilin
authors.initials: L
authors.lastname: Wang
authors.forename: Jillian A
authors.initials: JA
authors.lastname: Berkowitz
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Distel
authors.forename: Yvon E
authors.initials: YE
authors.lastname: Cayre
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000235:genetics / Q000473:pathology; D045744:Cell Line, Tumor; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods; D048429:Cell Size; D015179:Colorectal Neoplasms / Q000097:blood / Q000235:genetics / Q000473:pathology; D003584:Cytological Techniques / Q000295:instrumentation* / Q000379:methods*; D066246:ErbB Receptors / Q000235:genetics; D005091:Exons; D005374:Filtration / Q000295:instrumentation / Q000379:methods; D017353:Gene Deletion; D019073:HT29 Cells; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000097:blood / Q000235:genetics / Q000473:pathology; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D066246:ErbB Receptors