title: Tiliroside-derivatives enhance GLUT4 translocation via AMPK in muscle cells.
abstract: Tiliroside isolated from Chinese herb Potentilla chinensis showed therapeutic activities in diabetes. We synthesized 7 tiliroside-derivatives and examined their effects on surface GLUT4myc levels in muscle cells. Derivatives 2a and 3 increased surface GLUT4myc levels, and derivative 3 has the greatest potential. AMPK may be involved in tiliroside-derivatives-regulated GLUT4myc traffic.
authors.affiliation: Department of Immunology, Key Laboratory of Immuno Microenvironment and Disease of the Educational Ministry of China, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Lihuan
authors.initials: L
authors.lastname: Shi
authors.forename: Nan
authors.initials: N
authors.lastname: Qin
authors.forename: Lijuan
authors.initials: L
authors.lastname: Hu
authors.forename: Linjuan
authors.initials: L
authors.lastname: Liu
authors.forename: Hongquan
authors.initials: H
authors.lastname: Duan
authors.forename: Wenyan
authors.initials: W
authors.lastname: Niu
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry*; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D032342:Muscle Cells / Q000187:drug effects* / Q000378:metabolism*; D021381:Protein Transport / Q000187:drug effects; D051381:Rats
chemical_list: D005419:Flavonoids; D051275:Glucose Transporter Type 4; D007004:Hypoglycemic Agents; C052083:tiliroside