title: Histamine and TNF-alpha release by rat peritoneal mast cells stimulated with Trichomonas vaginalis.
abstract: Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-alpha and histamine. Rat peritoneal mast cells (RPMC), a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP) of T. vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-alpha. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis.
authors.affiliation: Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine, #17 Haengdang-dong, Sungdong-gu, Seoul 133-791, Korea.
authors.forename: S J
authors.initials: SJ
authors.lastname: Im
authors.forename: M H
authors.initials: MH
authors.lastname: Ahn
authors.forename: I H
authors.initials: IH
authors.lastname: Han
authors.forename: H O
authors.initials: HO
authors.lastname: Song
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: J S
authors.initials: JS
authors.lastname: Ryu
mesh_terms: D000818:Animals; D002633:Chemotaxis / Q000276:immunology; D003594:Cytoplasmic Granules / Q000502:physiology; D005089:Exocytosis; D006632:Histamine / Q000378:metabolism*; D006636:Histamine Release / Q000276:immunology; D008407:Mast Cells / Q000276:immunology* / Q000469:parasitology / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D010529:Peritoneal Cavity / Q000166:cytology* / Q000469:parasitology; D051381:Rats; D017208:Rats, Wistar; D014246:Trichomonas vaginalis / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D006632:Histamine