title: Adenovirus-Mediated Wild-Type p53 Gene Transfer into Head and Neck Cancers.
abstract: Mutation of the p53 tumor-suppressor gene is recognized as one of the most common genetic alterations in human malignancy to date (1). Approximately 60% of human tumors are thought to possess mutation at the p53 locus. Transient overexpression of the wild-type p53 gene in various malignancies has been considered a potential molecular intervention strategy (2 -7). This strategy is based on the role that wild-type p53 plays as a tumor-suppressor gene and inducer of cell-cycle arrest and apoptosis (1 ,8-11).
authors.affiliation: Department of Head and Neck Surgery, M.D. Anderson Cancer Center, University of Texas, Houston, TX.
authors.forename: G L
authors.initials: GL
authors.lastname: Clayman
authors.forename: D K
authors.initials: DK
authors.lastname: Frank
authors.forename: P A
authors.initials: PA
authors.lastname: Bruso