title: Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk.
abstract: Studies have linked prostate cancer risk with insulin resistance and obesity. Circulating levels of adiponectin, a protein involved in insulin resistance and obesity, have been associated with prostate cancer risk. We studied the association of prostate cancer risk with haplotype tagging single nucleotide polymorphisms (SNPs) of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) chosen based on their functional relevance or association with other types of cancer. DNA samples from 465 cases and 441 healthy volunteers from New York City were genotyped for ADIPOQ rs266729, rs822395, rs822396, rs1501299, and rs2241766 SNPs and ADIPOR1 rs12733285, rs1342387, rs7539542, rs2232853, and rs10920531 SNPs. We performed both single- and multiple-SNP analyses. We found that rs12733285, rs7539452, rs266729, rs822395, rs822396, and rs1501299 were significantly associated with prostate cancer risk. Haplotype analysis confirmed these results and identified 5 ADIPOQ 4-SNP haplotypes and 1 ADIPOR1 2-SNP haplotype tightly associated with prostate cancer risk. Importantly, 2 ADIPOQ SNPs, rs266729 and rs1501299, have been previously associated with colon and breast cancer risk, respectively, in the same direction as in this study. These findings suggest that variants of the adiponectin pathway may be associated with susceptibility to various forms of common cancers and warrant validation studies.
authors.affiliation: Cancer Genetics Program, Division of Hematology/Oncology, Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Virginia
authors.initials: V
authors.lastname: Kaklamani
authors.forename: Nengjun
authors.initials: N
authors.lastname: Yi
authors.forename: Kui
authors.initials: K
authors.lastname: Zhang
authors.forename: Maureen
authors.initials: M
authors.lastname: Sadim
authors.forename: Kenneth
authors.initials: K
authors.lastname: Offit
authors.forename: Carole
authors.initials: C
authors.lastname: Oddoux
authors.forename: Harry
authors.initials: H
authors.lastname: Ostrer
authors.forename: Christos
authors.initials: C
authors.lastname: Mantzoros
authors.forename: Boris
authors.initials: B
authors.lastname: Pasche
mesh_terms: D052242:Adiponectin / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004843:Epistasis, Genetic; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000209:etiology / Q000235:genetics*; D054419:Receptors, Adiponectin / Q000235:genetics*; D012306:Risk
chemical_list: C499918:ADIPOQ protein, human; C475418:ADIPOR1 protein, human; D052242:Adiponectin; D054419:Receptors, Adiponectin