title: Modulation of NF-κB signalling by microbial pathogens.
abstract: The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host response to infection by microbial pathogens, by orchestrating the innate and acquired host immune responses. The NF-κB proteins are activated by diverse signalling pathways that originate from many different cellular receptors and sensors. Many successful pathogens have acquired sophisticated mechanisms to regulate the NF-κB signalling pathways by deploying subversive proteins or hijacking the host signalling molecules. Here, we describe the mechanisms by which viruses and bacteria micromanage the host NF-κB signalling circuitry to favour the continued survival of the pathogen.
authors.affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, 1600 SW Archer Road, PO Box 100266, Gainesville, Florida, USA.
authors.forename: Masmudur M
authors.initials: MM
authors.lastname: Rahman
authors.forename: Grant
authors.initials: G
authors.lastname: McFadden
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology*; D007113:Immunity, Innate; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction; D014777:Virus Diseases / Q000276:immunology / Q000382:microbiology*; D014780:Viruses / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D016328:NF-kappa B