title: [Antiviral properties of the derivatives of netropsin and distamycin against herpes simplex viruses type 1 and variolovaccine].
abstract: The antiherpesvirus activity of newly synthesized DNA-binding compounds for cultured Vero E6 cells was examined. The compounds were found to have selective antiherpesviral activity. Their antiviral activity was shown against the virus strains isolated from clinical specimens. The test compounds were ascertained to have also a high activity against herpes simplex virus type 1 (HSV-1/L2 TC-) that was very resistant to acyclovir. The authors' data demonstrated an obvious dose-dependent antiviral effect, which was representatively seen when Pt-bis-Dst and Lys-bis-Nt were used. The findings have offered the challenge to test some of these compounds in experiments on laboratory animals.
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: S L
authors.initials: SL
authors.lastname: Grokhovskiĭ
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
authors.forename: P G
authors.initials: PG
authors.lastname: Deriabin
authors.forename: G V
authors.initials: GV
authors.lastname: Gurskiĭ
authors.forename: D K
authors.initials: DK
authors.lastname: L'vov
mesh_terms: D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004214:Distamycins / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009429:Netropsin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D004214:Distamycins; D009429:Netropsin; C030000:stallimycin; D000212:Acyclovir