title: Limited sampling strategies for the estimation of raltegravir daily exposure in HIV-infected patients.
abstract: Stepwise multiple regression analyses were applied to 50 raltegravir pharmacokinetic profiles from 50 HIV patients with the goal to identify limited sampling strategies for the prediction of drug area under the time-concentration curve (AUC(0-12)). Raltegravir single sampling point-based equations failed to reliably predict daily drug exposure. Conversely, different algorithms based on few samples and associated with good correlation, acceptable bias, and imprecision with the measured raltegravir AUC(0-12) were identified. These models could used to predict raltegravir exposure for clinic or research purposes.
authors.affiliation: Unit of Clinical Pharmacology, Luigi Sacco University Hospital, via GB Grassi 74, 20157 Milano, Italy. cattaneo.dario@hsacco.it
authors.forename: Dario
authors.initials: D
authors.lastname: Cattaneo
authors.forename: Diego
authors.initials: D
authors.lastname: Ripamonti
authors.forename: Cristina
authors.initials: C
authors.lastname: Gervasoni
authors.forename: Simona
authors.initials: S
authors.lastname: Landonio
authors.forename: Paola
authors.initials: P
authors.lastname: Meraviglia
authors.forename: Sara
authors.initials: S
authors.lastname: Baldelli
authors.forename: Valeria
authors.initials: V
authors.lastname: Cozzi
authors.forename: Serena
authors.initials: S
authors.lastname: Fucile
authors.forename: Emilio
authors.initials: E
authors.lastname: Clementi
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D019540:Area Under Curve; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011760:Pyrrolidinones / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D000068898:Raltegravir Potassium
chemical_list: D019380:Anti-HIV Agents; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium