title: Anthropometric measures at different ages and endometrial cancer risk.
abstract: BACKGROUND
  Endometrial cancer is strongly associated with body mass index (BMI), but the influence of BMI history and of different types of obesity is uncertain.
  
  
  METHODS
  A case-control study was carried out in Italy including 454 cases and 908 controls admitted to hospital for acute non-hormone-related conditions. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using multivariate logistic and spline regression models.
  
  
  RESULTS
  The OR for BMI >30 at diagnosis compared with 20 to <25 kg m(-2) was 4.08 (95% CI: 2.90-5.74). The association for BMI was monotonic with a possible steeper increase for BMI above 28. Conversely, waist-to-hip ratio (WHR) showed a bell shaped curve with increased OR (2.10; 95% CI: 1.43-3.09) in the intermediate tertile only. After stratification by BMI at diagnosis, history of weight loss and BMI at age 30 did not influence endometrial cancer risk. History of obesity in middle age had a weak and not significant adverse effect among obese women (OR=1.60; 95% CI: 0.52-4.96).
  
  
  CONCLUSIONS
  The predominant importance of recent weight compared to lifetime history, justifies encouraging weight reduction in women at any age.
authors.affiliation: SOC Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, 33081 Aviano (PN), Italy. epidemiology@cro.it
authors.forename: L
authors.initials: L
authors.lastname: Dal Maso
authors.forename: A
authors.initials: A
authors.lastname: Tavani
authors.forename: A
authors.initials: A
authors.lastname: Zucchetto
authors.forename: M
authors.initials: M
authors.lastname: Montella
authors.forename: M
authors.initials: M
authors.lastname: Ferraroni
authors.forename: E
authors.initials: E
authors.lastname: Negri
authors.forename: J
authors.initials: J
authors.lastname: Polesel
authors.forename: A
authors.initials: A
authors.lastname: Decarli
authors.forename: R
authors.initials: R
authors.lastname: Talamini
authors.forename: C
authors.initials: C
authors.lastname: La Vecchia
authors.forename: S
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000209:etiology*; D005260:Female; D006801:Humans; D007558:Italy; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D012306:Risk; D049629:Waist-Hip Ratio