title: Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes.
abstract: OBJECTIVE
  To evaluate the risk of funisitis among women with preterm prelabour rupture of the membranes (PPROM) and subsequent bleeding per vaginam.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  A University Hospital in the USA.
  
  
  METHODS
  A total of 157 women with PPROM, divided into those with bleeding per vaginam during the hospital admission (n = 46) and those without bleeding per vaginam (n = 111).
  
  
  METHODS
  Pathologist blinded to bleeding status assessed placental pathology for funisitis.
  
  
  METHODS
  Funisitis.
  
  
  RESULTS
  Women with bleeding per vaginam were more likely to have funisitis (67.4% versus 36%, P < 0.001) compared with those without bleeding. Logistic regression demonstrated that bleeding per vaginam predicted funisitis after controlling for gestational age at admission, latency period and gestational age at delivery.
  
  
  CONCLUSIONS
  Among women with PPROM, those with bleeding per vaginam are more likely to have funisitis than those without bleeding per vaginam.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, Durham, NC, USA. chad.grotegut@duke.edu
authors.forename: C A
authors.initials: CA
authors.lastname: Grotegut
authors.forename: L N C
authors.initials: LN
authors.lastname: Johnson
authors.forename: C B
authors.initials: CB
authors.lastname: Fitzpatrick
authors.forename: R P
authors.initials: RP
authors.lastname: Heine
authors.forename: G K
authors.initials: GK
authors.lastname: Swamy
authors.forename: A P
authors.initials: AP
authors.lastname: Murtha
mesh_terms: D000328:Adult; D002821:Chorioamnionitis / Q000209:etiology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012307:Risk Factors; D014592:Uterine Hemorrhage / Q000209:etiology*