title: Association between DARPP-32 gene polymorphism and personality traits in healthy Chinese-Han subjects.
abstract: The 32-kDa dopamine- and cAMP-regulated phosphoprotein (DARPP-32) is a key signaling factor in several neurotransmitter pathways (including dopamine and serotonin) that impact personality traits. Therefore, different DARPP-32 alleles may influence the biological determination of distinct personality types. We established an association between the DARPP-32 gene polymorphisms (rs12601930C/T, rs879606A/G, and rs3764352A/G) and personality traits as measured by the Tridimensional Personality Questionnaire in 502 healthy Chinese-Han subjects. Of the three polymorphic sites examined, rs12601930C/T was associated with novelty seeking (χ² = 13.06, P = 0.001), while both rs879606A/G and rs3764352A/G were associated with harm avoidance (rs879606: χ² = 7.74, P = 0.021; rs3764352: χ² = 8.53, P = 0.014). There was no significant association between reward dependence scores and DARPP-32 gene polymorphisms. Our results suggest that polymorphisms in the DARPP-32 gene are involved in the biological mechanisms that confer the traits of novelty seeking and harm avoidance.
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Jingying
authors.initials: J
authors.lastname: Li
authors.forename: Huan
authors.initials: H
authors.lastname: Ma
authors.forename: Hongxu
authors.initials: H
authors.lastname: Zhou
authors.forename: Yinglin
authors.initials: Y
authors.lastname: Huang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Zhu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D051937:Dopamine and cAMP-Regulated Phosphoprotein 32