title: Tpl2 kinase signal transduction in inflammation and cancer.
abstract: The activation of mitogen-activated protein kinases (MAPKs) is critically involved in inflammatory and oncogenic events. Tumor progression locus 2 (Tpl2), also known as COT and MAP3 kinase 8 (MAP3K8), is a serine-threonine kinase with an important physiological role in tumor necrosis factor, interleukin-1, CD40, Toll-like receptor and G protein-coupled receptor-mediated ERK MAPK signaling. Whilst the full characterization of the biochemical events that lead to the activation of Tpl2 still represent a major challenge, genetic and molecular evidence has highlighted interesting interactions with the NF-κB network. Here, we provide an overview of the multifaceted functions of Tpl2 and the molecular mechanisms that govern its regulation.
authors.affiliation: Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, Institute for Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas, Heraklion, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Vougioukalaki
authors.forename: Dimitris C
authors.initials: DC
authors.lastname: Kanellis
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Gkouskou
authors.forename: Aristides G
authors.initials: AG
authors.lastname: Eliopoulos
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000276:immunology; D020930:MAP Kinase Kinase Kinases / Q000276:immunology / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology* / Q000276:immunology; D011518:Proto-Oncogene Proteins / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011518:Proto-Oncogene Proteins; D020930:MAP Kinase Kinase Kinases; C069937:MAP3K8 protein, human