title: Impact of national transfusion indicators on appropriate blood usage in critically ill patients.
abstract: BACKGROUND
  The objective was to investigate the impact of three national blood transfusion indicators (NBTIs) specifically designed for critical care regarding the appropriate blood transfusion indications.
  
  
  METHODS
  This was a prospective, single-center study, carried out at a university hospital. A total of 1808 patients admitted to the intensive care unit (ICU) in 1 year were included.
  
  
  RESULTS
  The study consisted of four 90-day periods (P). P1 was a control period with no intervention. P2 followed the inclusion of NBTIs into the ICU database, aimed at reinforcing NBTI knowledge. After presenting and discussing the results of P1 and P2, the early (P3) and late (P4) impacts of NBTI knowledge were evaluated. All patients who were transfused with at least 1 unit of any blood component (33.3%) were included. Thirteen percent of red blood cell transfusions (RBCTs) were given outside of NBTI protocols (13% deviation of NBTIs for RBCTs) without a significant change throughout the duration of the study. Most RBCTs (95%) were prescribed for a hemoglobin threshold of less than 90 g/L. There was a steady and significant improvement in the adherence to NBTI guidelines for platelet concentrate transfusions (PCTs) from 36% (P1) to 52% (P4; p < 0.01). In contrast, the lack of adherence to NBTI guidelines for fresh-frozen plasma transfusions (FFPTs) remained high (74%) and stable throughout the study period. The most frequent reason for inappropriate use of FFPTs or PCTs was absence of severe bleeding.
  
  
  CONCLUSIONS
  The introduction of NBTI guidelines demonstrated a variable impact on the appropriateness of blood component transfusions in critically ill patients.
authors.affiliation: Critical Care Division, Hospital Universitario Virgen del Rocío, Seville, Spain. sramon@cica.es
authors.forename: Santiago Ramón
authors.initials: SR
authors.lastname: Leal-Noval
authors.forename: Victoria
authors.initials: V
authors.lastname: Arellano-Orden
authors.forename: Antonio
authors.initials: A
authors.lastname: Maestre-Romero
authors.forename: Manuel
authors.initials: M
authors.lastname: Muñoz-Gómez
authors.forename: Virginia
authors.initials: V
authors.lastname: Fernández-Cisneros
authors.forename: Carmen
authors.initials: C
authors.lastname: Ferrándiz-Millón
authors.forename: Yael
authors.initials: Y
authors.lastname: Corcia
mesh_terms: D000368:Aged; D001803:Blood Transfusion / Q000592:standards*; D016638:Critical Illness / Q000628:therapy*; D017707:Erythrocyte Transfusion / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies