title: [Clinical impact of HLA disparities in transplants from unrelated donors].
abstract: The search for an unrelated donor must be based on the HLA typing of the donor and the host. PCR techniques have facilitated high-resolution HLA typing, but they have also elicited questions about the real impact of the various disparities on the progress of the graft Thus, whereas a donor used to be accepted based on HLA-A and B Identity determined by serology and HLA-DRB1 through molecular biology techniques, now a donor is required to have a 70/70 Identity for loci HLA-A, B, C, DRB7, and DQB7. Furthermore, the real effect of the disparities in the sixth locus of the major histocompatibility complex-HLA-DPBT-is still in doubt. This study intends to conduct a literature review of the clinical impact of the various HLA disparities In transplants from unrelated donors.
authors.affiliation: Institut Català d'Oncologia, Hospital Josep Trueta, Gerona, España.
authors.forename: D
authors.initials: D
authors.lastname: Gallardo
mesh_terms: D046148:Donor Selection; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006682:HLA-DP Antigens / Q000276:immunology; D059868:HLA-DP beta-Chains; D006648:Histocompatibility; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D016377:Organ Transplantation; D016133:Polymerase Chain Reaction; D012699:Serology; D014019:Tissue Donors / Q000600:supply & distribution*
chemical_list: D006680:HLA Antigens; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen