title: Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection.
abstract: A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased levels of reactive oxygen species (ROS) produced in the respiration mutants increase HIF-1 activity and lead to this longevity. In this research perspective, we discuss our findings and recent advances regarding the roles of ROS and HIF-1 in aging, focusing on the longevity caused by reduced respiration.
authors.affiliation: Division of Molecular and Life Science, Pohang University of Science and Technology, Kyungbuk, South Korea.
authors.forename: Ara B
authors.initials: AB
authors.lastname: Hwang
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D019069:Cell Respiration; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000378:metabolism*; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D009154:Mutation; D017382:Reactive Oxygen Species / Q000378:metabolism*; D056811:Unfolded Protein Response
chemical_list: D029742:Caenorhabditis elegans Proteins; D051793:Hypoxia-Inducible Factor 1; D017382:Reactive Oxygen Species