title: Acinic cell carcinoma in pregnancy: a case report and review of the literature.
abstract: BACKGROUND
  We report an observational study on the etiology and recurrence of acinic cell carcinoma of the parotid gland that seemed to be related to pregnancy. The medical literature has never reported such an association; therefore, our case report is probably the first to mention this observation.
  
  
  METHODS
  This report is of a 25-year-old Arabic female patient from the United Arab Emirates, who, during her first pregnancy, developed acinic cell carcinoma of the right parotid gland that was managed with surgical excision in the form of superficial parotidectomy. During her second pregnancy, which occurred four years later, she had a recurrence of the same malignant neoplasm associated with ipsilateral malignant cervical lymphadenopathy. The patient was managed with total parotidectomy and neck dissection, as well as postoperative adjuvant radiotherapy. Our observation on this particular case of acinic cell carcinoma is that the initial onset of her neoplasm was during her first pregnancy, and the recurrence of the same malignant disease was during a subsequent pregnancy. This chronologic association raised our suspicion that there might be a possible etiologic effect of pregnancy or its associated hormonal or physiologic changes or both on the pathogenesis or etiology of acinic cell carcinoma.
  
  
  CONCLUSIONS
  Some association might exist between pregnancy and the pathogenesis or etiology of acinic cell carcinoma.
authors.affiliation: MBC 47, Department of Otolaryngology, Head & Neck Surgery and Communication Disorders, King Faisal Specialist Hospital & Research Centre, P,O, Box 3354, Riyadh 11211, Kingdom of Saudi Arabia. nalzaher@hotmail.com.
authors.forename: Nabil N
authors.initials: NN
authors.lastname: Al-Zaher
authors.forename: Amani A
authors.initials: AA
authors.lastname: Obeid