title: A general approach to high-yielding asymmetric synthesis of chiral 3-alkyl-4-nitromethylchromans via cascade Barbas-Michael and acetalization reactions.
abstract: A general approach to the high-yielding asymmetric synthesis of chiral 3-alkyl-4-nitromethylchromans as drug intermediates was achieved through cascade Barbas-Michael and acetalization (BMA) reactions on 2-(2-nitrovinyl)phenols with aldehydes in the presence of a catalytic amount of (R)-DPPOTMS and PhCO(2)H. Herein, we have also demonstrated the application of chiral BMA products in the synthesis of functionalized chromanes and chromenes in very good yields with high optical purity, which are very useful compounds in medicinal chemistry.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad-500 046, India. ramsc@uohyd.ernet.in
authors.forename: Dhevalapally B
authors.initials: DB
authors.lastname: Ramachary
authors.forename: M Shiva
authors.initials: MS
authors.lastname: Prasad
authors.forename: R
authors.initials: R
authors.lastname: Madhavachary
mesh_terms: D000080:Acetals / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D002867:Chromones / Q000138:chemical synthesis*; D008745:Methylation; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000080:Acetals; D002867:Chromones; D009574:Nitro Compounds