title: [Modulation of T1R chemosensory receptors for sweet nutrients - new paradigms in metabolic regulation].
abstract: Recent studies have demonstrated that the sweet-sensing receptors T1R2/3, thought to be "taste receptors" specifically expressed in lingual system, are also expressed and involved in the chemo-detection of sweetening molecules circulating in other organs. Researches that focus on their roles in intestinal absorption, metabolic regulation and glucose homeostasis, in particular, are increasing. Indeed, the sweet-sensing receptor could provide a new therapeutic target for certain metabolic disorders and diseases like obesity and diabetes. If the natural and artificial sweeteners agonists are diverse and well known, the "anti-sweeteners" antagonistic molecules are a class of compounds that received very little attention until now. Their potential roles and pharmacological relevance outside the taste system are discussed. Moreover, the recent finding that 2 major classes of compounds belonging respectively to the fields of medicine (fibrates) and agriculture (phenoxy-herbicides) are potent inhibitors of human T1R3 receptor is reported, raising new questions about their potential impact on human metabolism.
authors.affiliation: New York University School of Medicine, Department of Pharmacology, MSB, 550 First Avenue, New York, NY 10016, États-Unis. emeline.maillet@nyumc.org
authors.forename: Emeline L
authors.initials: EL
authors.lastname: Maillet
mesh_terms: D058607:Fibric Acids; D006540:Herbicides; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D013549:Sweetening Agents; D013649:Taste / Q000502:physiology*
chemical_list: D058607:Fibric Acids; D006540:Herbicides; D043562:Receptors, G-Protein-Coupled; D013549:Sweetening Agents; C431926:taste receptors, type 1