title: Relative acidity scale of glycine- and taurine-conjugated bile acids through ESI-MS measurements.
abstract: The most important bile acids, in the form of glycine and taurine conjugates, have been ordered in terms of relative acidity scale. The measurements have been carried out using mass spectrometric techniques. The group of taurine conjugates confirm the superior acidity over the glycine derivatives. Rationale of the differences found in gas-phase and comparison with the data reported in solution-phase are discussed with the support of theoretical calculations. The study has been completed with the acidity sequence of mixed oxo-hydroxy bile acids.
authors.affiliation: Dipartimento di Chimica, Università di Ferrara, Via Borsari 46, 44100 Ferrara, Italy. olga.bortolini@unife.it
authors.forename: Olga
authors.initials: O
authors.lastname: Bortolini
authors.forename: Tatiana
authors.initials: T
authors.lastname: Bernardi
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Fantin
authors.forename: Valeria
authors.initials: V
authors.lastname: Ferretti
authors.forename: Marco
authors.initials: M
authors.lastname: Fogagnolo
mesh_terms: D005998:Glycine / Q000737:chemistry*; D006000:Glycocholic Acid / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008968:Molecular Conformation; D015394:Molecular Structure; D011522:Protons; D021241:Spectrometry, Mass, Electrospray Ionization; D013654:Taurine / Q000737:chemistry*; D013656:Taurocholic Acid / Q000737:chemistry*
chemical_list: D011522:Protons; D013654:Taurine; D013656:Taurocholic Acid; D006000:Glycocholic Acid; D005998:Glycine