title: piRNAs meet mitochondria.
abstract: zuc/MitoPLD encodes a conserved enzyme that localizes to mitochondria and hydrolyzes the mitochondria-specific lipid cardiolipin. Surprisingly, zuc/MitoPLD activity is required for Piwi-interacting RNA (piRNA)-mediated silencing of transposable elements in fly and mouse germlines, suggesting that signaling from mitochondria influences the piRNA pathway.
authors.affiliation: California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. aaa@caltech.edu
authors.forename: Alexei A
authors.initials: AA
authors.lastname: Aravin
authors.forename: David C
authors.initials: DC
authors.lastname: Chan