title: [Limitation of apoptosis induced by gefitinib in a long-surviving postoperative recurrent lung cancer case].
abstract: Although gefitinib is known to possess an effect inducing apoptosis against lung cancer, it is not clear how clinically effective it is in this regard in patients with lung cancer. Therefore, we tried to reduce its administration from every to every other day in a 73-year-old woman in good condition over 5 years after the recurrence of lung cancer. As a result, her CEA serum level then commenced to increase to the abnormal range within a month. Apoptosis induced by gefitinib was thought not sufficient to kill all lung cancer cells even though well controlled by it for a long period.
authors.affiliation: Dept. of Chest Surgery, Aichi Cancer Center Aichi Hospital.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sakakura
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Uchida
authors.forename: Motokazu
authors.initials: M
authors.lastname: Suyama
mesh_terms: D000368:Aged; D017209:Apoptosis / Q000187:drug effects*; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D012008:Recurrence; D012074:Remission Induction; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000077156:Gefitinib