title: Increased left parietal volumes relate to delayed language development in autism: a structural mri study.
abstract: The neural basis of language and motor deficits in autism is still not completely clear. The aim of this study was to explore the involvement of the parietal lobe in language and motor development in autism, in view of the recognized role of this region in language and imitation functions. Twenty-eight autistic children underwent an extensive clinical assessment and an MRI examination. A significant direct correlation between age at first word and left parietal gray matter volumes was found (r=0.50, p=0.007). Conversely, age at reaching milestones of motor development, such as the ability to sit and to walk unaided, was not significantly associated with parietal size, after correcting for chronological age and for gender. To the best of our knowledge, this is the first structural MRI report demonstrating a role of left parietal gray matter volumes in delayed language development in autistic children representative of the 'real world' autistic population.
authors.affiliation: Department of Reproduction and Life Sciences, University of Verona, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Zoccante
authors.forename: Anna
authors.initials: A
authors.lastname: Viviani
authors.forename: Adele
authors.initials: A
authors.lastname: Ferro
authors.forename: Roberto
authors.initials: R
authors.lastname: Cerini
authors.forename: Stefania
authors.initials: S
authors.lastname: Cerruti
authors.forename: Gianluca
authors.initials: G
authors.lastname: Rambaldelli
authors.forename: Marcella
authors.initials: M
authors.lastname: Bellani
authors.forename: Nicola
authors.initials: N
authors.lastname: Dusi
authors.forename: Cinzia
authors.initials: C
authors.lastname: Perlini
authors.forename: Flavio
authors.initials: F
authors.lastname: Boscaini
authors.forename: Roberto
authors.initials: R
authors.lastname: Pozzi Mucelli
authors.forename: Michele
authors.initials: M
authors.lastname: Tansella
authors.forename: Bernardo
authors.initials: B
authors.lastname: Dalla Bernardina
authors.forename: Paolo
authors.initials: P
authors.lastname: Brambilla
mesh_terms: D001321:Autistic Disorder / Q000473:pathology*; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007805:Language Development Disorders / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D010296:Parietal Lobe / Q000473:pathology*