title: Total and acylated ghrelin levels in children with poor growth.
abstract: Ghrelin, an enteric hormone with potent appetite stimulating effects, also stimulates growth hormone release. We hypothesized that altered levels of total ghrelin (TG) or acylated ghrelin (AG) could affect growth by altering growth hormone secretion, subsequently affecting insulin-like growth factor-1 (IGF-1) generation or by altering appetite and food intake. After institutional review board approval, 52 children presenting for evaluation of chronic gastrointestinal symptoms (group 1), poor weight gain (group 2), or poor linear growth (group 3) were evaluated for fasting TG and AG levels in addition to their regular evaluation. Serum ghrelin, IGF-1, and prealbumin were compared between groups. No difference was observed for mean fasting TG between groups. However, mean fasting AG was highest in patients in group 2 (465 ± 128 pg/mL) versus group 1 (176 ± 37 pg/mL) and group 3 (190 ± 34 pg/mL). IGF-1 was lowest in patients in group 2 despite similar prealbumin levels among the three groups. We conclude that serum AG levels are highest in children with isolated poor weight gain compared with children with short stature or chronic gastrointestinal symptoms, suggesting the possibility of resistance to AG in underweight children. Additional studies are needed to further clarify ghrelin's role in growth and appetite.
authors.affiliation: Department of Pediatrics, Tripler Army Medical Center, Honolulu, Hawaii 96859, USA. jordan.pinsker@us.army.mil
authors.forename: Jordan E
authors.initials: JE
authors.lastname: Pinsker
authors.forename: Deborah
authors.initials: D
authors.lastname: Ondrasik
authors.forename: Debora
authors.initials: D
authors.lastname: Chan
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Fredericks
authors.forename: Eludrizza
authors.initials: E
authors.lastname: Tabisola-Nuesca
authors.forename: Minela
authors.initials: M
authors.lastname: Fernandez-Aponte
authors.forename: Dean R
authors.initials: DR
authors.lastname: Focht
authors.forename: Merrily
authors.initials: M
authors.lastname: Poth
mesh_terms: D000215:Acylation; D000293:Adolescent; D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood* / Q000503:physiopathology; D054439:Ghrelin / Q000097:blood* / Q000737:chemistry; D006130:Growth Disorders / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D054439:Ghrelin