title: In vivo activity of benzoyl ester clerodane diterpenoid derivatives from Dodonaea polyandra.
abstract: Four new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8α-(benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8α-(benzoyloxy)methyl-2α-hydroxycleroda-3,13(16),14-trien-18-oic acid (2), 15,16-epoxy-8α-(benzoyloxy)methyl-2-oxocleroda-3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2α-benzoyloxycleroda-3,13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 μmol/ear, respectively. Modest activity (~45% inhibition) was maintained at nanomole/ear doses.
authors.affiliation: Sansom Institute for Health Research, University of South Australia, Frome Road, Adelaide, 5000, South Australia. bradley.simpson@unisa.edu
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Simpson
authors.forename: David J
authors.initials: DJ
authors.lastname: Claudie
authors.forename: Jacobus P
authors.initials: JP
authors.lastname: Gerber
authors.forename: Simon M
authors.initials: SM
authors.lastname: Pyke
authors.forename: Jiping
authors.initials: J
authors.lastname: Wang
authors.forename: Ross A
authors.initials: RA
authors.lastname: McKinnon
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Semple
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D004195:Disease Models, Animal; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced; D051379:Mice; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D029631:Sapindaceae / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D045785:Diterpenes, Clerodane; D013755:Tetradecanoylphorbol Acetate