title: Transition metal complexes of 2, 6-di ((phenazonyl-4-imino) methyl)-4-methylphenol: structure and biological evaluation.
abstract: A symmetric ligand 2, 6-di ((phenazonyl-4-imino)methyl)-4-methylphenol (Dpmp) and its cobalt dinuclear complex (Co2(Dpmp)2(NO3)2(H2O)2·NO3·EtOH, (1) and zinc mononuclear complex Zn(Dpmp)(NO3)2, (2) have been prepared. The crystal structures were determined by single-crystal X-ray diffraction. The biological activity has been evaluated by examining their anti-oxidative activity and ability to bind to bovine serum albumin (BSA) and calf-thymus DNA (CT DNA) with UV-vis absorption, fluorescence, viscosity measurements and circular dichroism (CD) spectroscopies. The complexes exhibit good binding propensity to BSA and CT DNA. Both 1 and 2 have been found to promote cleavage of pUC19 DNA in the absence of any reducing agent. Antioxidant tests in vitro show the compounds possess significant antioxidant activity against superoxide and hydroxyl radicals.
authors.affiliation: Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Liu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Shi
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Zhengpeng
authors.initials: Z
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Huang
authors.forename: Decheng
authors.initials: D
authors.lastname: Bai
authors.forename: ZhengZhi
authors.initials: Z
authors.lastname: Zeng
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D002417:Cattle; D018360:Crystallography, X-Ray; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010636:Phenols / Q000737:chemistry*; D017510:Protein Folding / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D028561:Transition Elements / Q000737:chemistry*
chemical_list: C559780:2, 6-di ((phenazonyl-4-imino) methyl)-4-methylphenol; D000975:Antioxidants; D007093:Imidazoles; D009942:Organometallic Compounds; D010636:Phenols; D017382:Reactive Oxygen Species; D012709:Serum Albumin; D028561:Transition Elements