title: Is serum thioredoxin-1 a useful clinical marker for malignant pleural mesothelioma?
abstract: Malignant pleural mesothelioma (MPM), an asbestos-related aggressive malignant tumor of mesothelial origin, shows limited response to therapy and overall survival remains very poor. Reactive oxygen species play an important role in asbestos toxicity. Here, we found that the patients with MPM had significantly higher serum levels of thioredoxin-1 (TRX) than control population. The patients with advanced-stage MPM showed higher levels of TRX than those with early-stage MPM. The difference in overall survival between the groups with lower and higher serum TRX levels was significant. Our data suggest that serum TRX concentration could be a useful clinical marker for MPM.
authors.affiliation: Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Maeda
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tabata
authors.forename: Rie
authors.initials: R
authors.lastname: Tabata
authors.forename: Ryoji
authors.initials: R
authors.lastname: Eguchi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fujimori
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000328:Adult; D000368:Aged; D001194:Asbestos / Q000633:toxicity; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000097:blood / Q000139:chemically induced / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D010997:Pleural Neoplasms / Q000097:blood / Q000139:chemically induced / Q000473:pathology*; D011379:Prognosis; D013879:Thioredoxins / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D001194:Asbestos; D013879:Thioredoxins