title: [Cardiovascular risk factors in Spain in the first decade of the 21st Century, a pooled analysis with individual data from 11 population-based studies: the DARIOS study].
abstract: OBJECTIVE
  To estimate the prevalence of cardiovascular risk factors in individuals aged 35-74 years in 10 of Spain's autonomous communities and determine the geographic variation of cardiovascular risk factors distribution.
  
  
  METHODS
  Pooled analysis with individual data from 11 studies conducted in the first decade of the 21st century. The average response rate was 73%. Lipid profile (with laboratory cross-validation), glucose level, blood pressure, waist circumference, height, and weight were measured and standard questionnaires administered. Age-standardized prevalence of smoking, diabetes, hypertension, dyslipidemia, and obesity in the European population were calculated. Furthermore, the coefficient of variation between component studies was determined for the prevalence of each risk factor.
  
  
  RESULTS
  In total, 28,887 participants were included. The most prevalent cardiovascular risk factors were high blood pressure (47% in men, 39% in women), total cholesterol ≥ 250 mg/dL (43% and 40%, respectively), obesity (29% and 29%, respectively), tobacco use (33% and 21%, respectively), and diabetes (16% and 11%, respectively). Total cholesterol ≥ 190 and ≥ 250 mg/dL were the respective minimum and maximum coefficients of variation (7%-24% in men, 7%-26% in women). Average concordance in lipid measurements between laboratories was excellent.
  
  
  CONCLUSIONS
  Prevalence of high blood pressure, dyslipidemia, obesity, tobacco use and diabetes is high. Little variation was observed between autonomous communities in the population aged 35-74 years. However, presence of the most prevalent cardiovascular risk factors in the Canary Islands, Extremadura and Andalusia was greater than the mean of the 11 studies.
authors.affiliation: Grupo de Epidemiología y Genética Cardiovascular, Programa de Investigación en Procesos Inflamatorios y Cardiovasculares, Instituto Municipal de Investigación Médica, Barcelona, España.
authors.forename: María
authors.initials: M
authors.lastname: Grau
authors.forename: Roberto
authors.initials: R
authors.lastname: Elosua
authors.forename: Antonio
authors.initials: A
authors.lastname: Cabrera de León
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Guembe
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Baena-Díez
authors.forename: Tomás
authors.initials: T
authors.lastname: Vega Alonso
authors.forename: Francisco
authors.initials: F
authors.lastname: Javier Félix
authors.forename: Belén
authors.initials: B
authors.lastname: Zorrilla
authors.forename: Fernando
authors.initials: F
authors.lastname: Rigo
authors.forename: José
authors.initials: J
authors.lastname: Lapetra
authors.forename: Diana
authors.initials: D
authors.lastname: Gavrila
authors.forename: Antonio
authors.initials: A
authors.lastname: Segura
authors.forename: Héctor
authors.initials: H
authors.lastname: Sanz
authors.forename: Daniel
authors.initials: D
authors.lastname: Fernández-Bergés
authors.forename: Montserrat
authors.initials: M
authors.lastname: Fitó
authors.forename: Jaume
authors.initials: J
authors.lastname: Marrugat
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005843:Geography; D006306:Health Surveys; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D050177:Overweight / Q000453:epidemiology; D011153:Population; D012307:Risk Factors; D012907:Smoking; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose; D008055:Lipids