title: [Association of polymorphism in the serotonin transporter gene promote with the susceptibility to alcohol dependence in Yunnan Han Population].
abstract: To explore the association of polymorphism in the serotonin transporter gene and the susceptibility to alcohol dependence in Yunnan Han population, PCR and DNA sequencing techniques were used to detect 5-HTT-linked promoter region (5-HTTLPR). One hundred and eighteen alcohol dependent patients as case group and 214 normal people as control group were employed in this study. Significant differences in genotype frequencies were present between case group and control group of 5-HTTLPR (P<0.05). The proportion of L/L and L/S genotype was significantly smaller in case group than that was in control group (OR=0.581, P=0.026). No significant association was observed in allelic frequencies, which differed in different ethnic groups. In conclusion, 5-HTTLPR polymorphism may be associated with alcohol dependent patients, and the genotype L/L or L/S may be a genetic factor that is responsible for decreasing susceptibility of alcohol dependence in Yunnan Han population.
authors.affiliation: Department of Forensic Medicine, Kunming Medical University, Kunming 650500, China. wangxuejing-2006@163.com
authors.forename: Xue-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Shu-Rong
authors.initials: SR
authors.lastname: Zhong
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Bao
authors.forename: Shao-Jing
authors.initials: SJ
authors.lastname: Dou
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Wu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Jing
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics*; D002681:China / Q000208:ethnology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins