title: A novel model for diffusion based release kinetics using an inverse numerical method.
abstract: We developed and analyzed an inverse numerical model based on Fick's second law on the dynamics of drug release. In contrast to previous models which required two state descriptions of diffusion for long- and short-term release processes, our model is valid for the entire release process. The proposed model may be used for identifying and reducing experimental errors associated with measurements of diffusion based release kinetics. Knowing the initial and boundary conditions, and assuming Fick's second law to be appropriate, we use the methods of Lagrange multiplier along with least-square algorithms to define a cost function which is discretized using finite difference methods and is optimized so as to minimize errors. Our model can describe diffusion based release kinetics for static and dynamic conditions as accurately as finite element methods, but results are obtained in a fraction of CPU time. Our method can be widely used for drug release procedures and for tissue engineering/repair applications where oxygenation of cells residing within a matrix is important.
authors.affiliation: The Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. hadim74@gmail.com
authors.forename: Hadi
authors.initials: H
authors.lastname: Mohammadi
authors.forename: Walter
authors.initials: W
authors.lastname: Herzog
mesh_terms: D000818:Animals; D002417:Cattle; D004058:Diffusion; D016503:Drug Delivery Systems; D007700:Kinetics; D008962:Models, Theoretical; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013997:Time Factors
chemical_list: D012710:Serum Albumin, Bovine; D011142:Polyvinyl Alcohol