title: Controllable exploding microcapsules as drug carriers.
abstract: Controllable exploding polyelectrolyte microcapsules were developed by layer-by-layer assembly of poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on a dextran microgel core containing a cleavable disulfide bond fabricated via click chemistry. The microcapsules can explode upon the injection of DTT with an explosive release of the drug.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Cao
authors.initials: C
authors.lastname: Li
authors.forename: Ya
authors.initials: Y
authors.lastname: Wang
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D002214:Capsules; D057930:Click Chemistry; D003911:Dextrans / Q000737:chemistry; D004229:Dithiothreitol / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008968:Molecular Conformation; D011073:Polyamines / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D002214:Capsules; D003911:Dextrans; D004337:Drug Carriers; D011073:Polyamines; D011108:Polymers; D013451:Sulfonic Acids; C063994:polyallylamine; D004229:Dithiothreitol; C077114:styrenesulfonic acid polymer