title: [PI3K inhibitor].
abstract: PI3K-Akt is an important signal transduction pathway which acts downstream from various growth factor receptors. The PI3K-Akt pathway is activated in many types of cancers by several mechanisms, including growth factor receptor activation, loss of PTEN, and PI3K gene mutations. Therefore, PI3K is thought to be an ideal therapeutic target. A large number of PI3K inhibitors are being developed and evaluated in clinical trials.
authors.affiliation: Division of Medical Oncology Cancer Research Institute, Kanazawa University, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Yano
authors.forename: Shinji
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Yamada
authors.forename: Hisatsugu
authors.initials: H
authors.lastname: Mouri
authors.forename: Kaname
authors.initials: K
authors.lastname: Yamashita
authors.forename: Koushiro
authors.initials: K
authors.lastname: Ohtsubo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yasumoto
mesh_terms: D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt