title: Mechanisms of aneuploidy and its suppression by tumour suppressor proteins.
abstract: Aneuploidy, as a result of numerical changes in chromosome number, was observed in tumours almost a century ago. The molecular mechanisms underlying this phenomenon and their impact on tumour development are still poorly understood. A series of recent observations provide direct linkages between the normal function of tumour suppressor proteins and the suppression of aneuploidy. The prospects that these findings offer for understanding the role of aneuploidy in cancer are discussed in this review.
authors.affiliation: Institute of Cell Biology, ETH Zurich, Switzerland. cthoma1@rics.bwh.harvard.edu
authors.forename: Claudio R
authors.initials: CR
authors.lastname: Thoma
authors.forename: Alberto
authors.initials: A
authors.lastname: Toso
authors.forename: Patrick
authors.initials: P
authors.lastname: Meraldi
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Krek
mesh_terms: D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics / Q000378:metabolism; D000782:Aneuploidy; D043171:Chromosomal Instability / Q000235:genetics; D018816:Genes, cdc; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics / Q000378:metabolism; D000099229:RE1-Silencing Transcription Factor
chemical_list: D025601:Adenomatous Polyposis Coli Protein; D012097:Repressor Proteins; D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D000099229:RE1-Silencing Transcription Factor