title: Inhibitory effect of glucodistylin from the bark of Quercus acutissima on human recombinant aldose reductase and sorbitol accumulation.
abstract: A flavanol glycoside, glucodistylin (1) and three polyphenol derivatives, gallate (2), (+)-catechin (3) and (+)-gallocatechin (4) were isolated from an aqueous acetone extract of the bark of Quercus acutissima. Of these compounds, glucodistylin exhibited uncompetitive inhibitory activity against recombinant human aldose reductase with an IC(50) value of 7.2 μM. Furthermore, glucodistylin inhibited sorbitol accumulation by 48.84% at 50 μM. This flavonoid showed therapeutic potential in the prevention and treatment of diabetes-related complications.
authors.affiliation: Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, Korea.
authors.forename: Yeon Sil
authors.initials: YS
authors.lastname: Lee
authors.forename: Jin Kyu
authors.initials: JK
authors.lastname: Kim
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Bae
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
authors.forename: Il-Jun
authors.initials: IJ
authors.lastname: Kang
authors.forename: Soon Sung
authors.initials: SS
authors.lastname: Lim
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D048909:Diabetes Complications / Q000188:drug therapy / Q000517:prevention & control; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D058990:Molecular Targeted Therapy; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D024301:Plant Bark; D059808:Polyphenols; D029963:Quercus; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013012:Sorbitol / Q000378:metabolism*
chemical_list: D005419:Flavonoids; D044948:Flavonols; D006027:Glycosides; D010636:Phenols; D059808:Polyphenols; D011994:Recombinant Proteins; C561199:glucodistylin; D013012:Sorbitol; D002392:Catechin; D000449:Aldehyde Reductase; C057580:gallocatechol