title: From imaging to dosimetry and biological effects.
abstract: The essential steps are explained in calculating a radiation dose for radionuclide therapy from imaging data. As the dose alone is a meaningless value, its consequences in tumour cell kill efficiency and normal tissue damage are explained. The influence of dose rate and inhomogeneous dose distributions are discussed.
authors.affiliation: Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands. m.konijnenberg@erasmusmc.nl
authors.forename: M
authors.initials: M
authors.lastname: Konijnenberg
mesh_terms: D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy*; D011853:Radiobiology / Q000706:statistics & numerical data; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D011878:Radiotherapy / Q000379:methods / Q000706:statistics & numerical data; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D019275:Radiopharmaceuticals