title: The effect on serum myeloperoxidase activity and oxidative status of eradication treatment in patients Helicobacter pylori infected.
abstract: OBJECTIVE
  Myeloperoxidase activity has been investigated after eradication of Helicobacter pylori (H. pylori) in infected patients in previous studies but the results are controversial. The aim of this study was to investigate effect on serum myeloperoxidase activity and oxidative status of eradication treatment in H. pylori-infected patients.
  
  
  METHODS
  Gastric biopsy specimens were obtained from 30 H. pylori infected patients. Serum myeloperoxidase activity was measured by enzyme-linked immunoassay. Oxidative status was determined using total antioxidant capacity (TAC) and total oxidant status (TOS) measurement and calculation of oxidative stress index (OSI).
  
  
  RESULTS
  After 2 weeks of the eradication treatment, serum myeloperoxidase activity, TOS and OSI values were significantly lower (all; p<0.001), while TAC was significantly higher (p<0.001).
  
  
  CONCLUSIONS
  Our results indicate that eradication treatment in H. pylori-infected patients may affect both oxidative stress and myeloperoxidase activity which is an important biomarker in pathogenesis of atherosclerosis.
authors.affiliation: Kecioren Research Hospital, Department of Gastroenterology, Ankara, Turkey.
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Nazligul
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Horoz
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Celik
authors.forename: Ahmet Cumhur
authors.initials: AC
authors.lastname: Dulger
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D009195:Peroxidase / Q000097:blood* / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D009195:Peroxidase