title: The use of nanocrystalline cellulose for the binding and controlled release of drugs.
abstract: The objective of this work was to investigate the use of nanocrystalline cellulose (NCC) as a drug delivery excipient. NCC crystallites, prepared by an acid hydrolysis method, were shown to have nanoscopic dimensions and exhibit a high degree of crystallinity. These crystallites bound significant quantities of the water soluble, ionizable drugs tetratcycline and doxorubicin, which were released rapidly over a 1-day period. Cetyl trimethylammonium bromide (CTAB) was bound to the surface of NCC and increased the zeta potential in a concentration-dependent manner from -55 to 0 mV. NCC crystallites with CTAB-modified surfaces bound significant quantities of the hydrophobic anticancer drugs docetaxel, paclitaxel, and etoposide. These drugs were released in a controlled manner over a 2-day period. The NCC-CTAB complexes were found to bind to KU-7 cells, and evidence of cellular uptake was observed.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada.
authors.forename: John K
authors.initials: JK
authors.lastname: Jackson
authors.forename: Kevin
authors.initials: K
authors.lastname: Letchford
authors.forename: Benjamin Z
authors.initials: BZ
authors.lastname: Wasserman
authors.forename: Lucy
authors.initials: L
authors.lastname: Ye
authors.forename: Wadood Y
authors.initials: WY
authors.lastname: Hamad
authors.forename: Helen M
authors.initials: HM
authors.lastname: Burt
mesh_terms: D045744:Cell Line, Tumor; D002482:Cellulose / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D019793:Fluorescein; D006801:Humans; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D033362:Powder Diffraction
chemical_list: D002593:Cetrimonium Compounds; D003692:Delayed-Action Preparations; D002482:Cellulose; D019793:Fluorescein; D000077286:Cetrimonium