title: Pharmacodynamic study of polymerized porcine hemoglobin (pPolyHb) in a rat model of exchange transfusion.
abstract: The objective of the present study is to evaluate the pharmacodynamic properties of polymerized porcine hemoglobin (pPolyHb) in an exchange transfusion model. Each of two groups of rats received a volume of pPolyHb or hetastarch that equalled 120-140% of estimated total blood volume (70 ml/kg) exchange transfusion. The results showed pPolyHb retained hemodynamic stability and exhibited superior volume expansion capability. Furthermore, pPolyHb effectively reverse anaerobic metabolism caused by a large amount of volume exchange. In comparison with hetastarch, pPolyHb increased blood oxygen content and tissue oxygenation. All these properties contribute to a higher effectiveness in sustaining the lives of rats in pPolyHb group.
authors.affiliation: College of Life Science, Northwest University, Xi'an, P. R. China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhu
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Dang
authors.forename: Kunping
authors.initials: K
authors.lastname: Yan
authors.forename: Penggao
authors.initials: P
authors.lastname: Dai
authors.forename: Chao
authors.initials: C
authors.lastname: Luo
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Thomas Ming Swi
authors.initials: TM
authors.lastname: Chang
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D000693:Anaerobiosis / Q000187:drug effects; D000818:Animals; D005078:Exchange Transfusion, Whole Blood; D005976:Glutaral / Q000737:chemistry; D006439:Hemodynamics / Q000187:drug effects; D006454:Hemoglobins / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage; D008297:Male; D023421:Models, Animal; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D058105:Polymerization; D051381:Rats / Q000276:immunology; D017207:Rats, Sprague-Dawley; D013552:Swine
chemical_list: D006454:Hemoglobins; D006895:Hydroxyethyl Starch Derivatives; D010100:Oxygen; D005976:Glutaral