title: Prostate cancer postoperative nomogram scores and obesity.
abstract: OBJECTIVE
  Nomograms are tools used in clinical practice to predict cancer outcomes and to help make decisions regarding management of disease. Since its conception, utility of the prostate cancer nomogram has more than tripled. Limited information is available on the relation between the nomograms' predicted probabilities and obesity. The purpose of this study was to examine whether the predictions from a validated postoperative prostate cancer nomogram were associated with obesity.
  
  
  METHODS
  We carried out a cross-sectional analysis of 1220 patients who underwent radical prostatectomy (RP) in southern California from 2000 to 2008. Progression-free probabilities (PFPs) were ascertained from the 10-year Kattan postoperative nomogram. Multivariable logistic regression models estimated odds ratios (ORs) and 95% confidence intervals (CIs).
  
  
  RESULTS
  In the present study, aggressive prostate cancer (Gleason ≥7), but not advanced stage, was associated with obesity (p = 0.01). After adjusting for age, black race, family history of prostate cancer and current smoking, an inverse association was observed for 10-year progression-free predictions (OR = 0.50; 95% CI = 0.28-0.90) and positive associations were observed for preoperative PSA levels (OR = 1.23; 95% CI = 1.01-1.50) and Gleason >7 (OR = 1.45; 95% CI = 1.11-1.90).
  
  
  CONCLUSIONS
  Obese RP patients were more likely to have lower PFP values than non-obese patients, suggesting a higher risk of experiencing prostate cancer progression. Identifying men with potentially higher risks due to obesity may improve disease prognosis and treatment decision-making.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, Maryland, United States of America. jacqueline.major@nih.gov
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Major
authors.forename: Hillary S
authors.initials: HS
authors.lastname: Klonoff-Cohen
authors.forename: John P
authors.initials: JP
authors.lastname: Pierce
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Slymen
authors.forename: Sidney L
authors.initials: SL
authors.lastname: Saltzstein
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Macera
authors.forename: Dan
authors.initials: D
authors.lastname: Mercola
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kattan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049451:Nomograms; D009765:Obesity / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D011184:Postoperative Period; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D012107:Research Design