title: Synthesis and biological evaluation of fused oxepinocoumarins as free radicals scavengers.
abstract: Some fused dihydrooxepino[f]-, [g]-, and [h]coumarins were obtained from the ring-closing metathesis of the corresponding o-allyl-allyloxycoumarins under the treatment with the first generation Grubbs' catalyst. These compounds were tested in vitro for their antioxidant activity, and they present significant scavenging activity. They were also showed to inhibit in vitro soybean lipoxygenase.
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece. klitinas@chem.auth.gr
authors.forename: Konstantinos E
authors.initials: KE
authors.lastname: Litinas
authors.forename: Alexandros
authors.initials: A
authors.lastname: Mangos
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Nikkou
authors.forename: Dimitra J
authors.initials: DJ
authors.lastname: Hadjipavlou-Litina
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000737:chemistry; D019787:Linoleic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008084:Lipoxygenase / Q000378:metabolism*; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D013025:Glycine max / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D001713:Biphenyl Compounds; D003374:Coumarins; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D010851:Picrates; D017665:Hydroxyl Radical; D019787:Linoleic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D008084:Lipoxygenase