title: Antimicrobial activity of the constituents of Smallanthus sonchifolius leaves against methicillin-resistant Staphylococcus aureus.
abstract: OBJECTIVE
  Methicillin-resistant Staphylococcus aureus (MRSA) has been a serious problem as its infection is associated with higher mortality and increase cost worldwide. In the present study, the antibacterial activity of enhydrin, polymatin B, allo-schkuhriolide from the leaves of Smallanthus sonchifolius was investigated.
  
  
  METHODS
  Enhydrin, polymatin B, allo-schkuhriolide from the leaves of Smallanthus sonchifolius were tested for antimicrobial activity using micro dilution broth method against 2 strains of ATCC 33591, ATCC 25923 and 15 strains of clinical isolates MRSA.
  
  
  RESULTS
  The antibacterial activity of Smallanthus sonchifolius can safely be attributed to enhydrin as polymatin B, and allo-schkuhriolide are not showing any activity against Staphylococcus aureus strains. The enhydrin showed good antibacterial activity against all tested strains (MIC = 125-500 microg/ml).
  
  
  CONCLUSIONS
  These results suggest that only enhydrin can be considered as an antibacterial drug against MRSA.
authors.affiliation: Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Jeonbuk, Republic of Korea.
authors.forename: J G
authors.initials: JG
authors.lastname: Choi
authors.forename: O H
authors.initials: OH
authors.lastname: Kang
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
authors.forename: Y C
authors.initials: YC
authors.lastname: Oh
authors.forename: H S
authors.initials: HS
authors.lastname: Chae
authors.forename: B
authors.initials: B
authors.lastname: Obiang-Obounou
authors.forename: S C
authors.initials: SC
authors.lastname: Park
authors.forename: D W
authors.initials: DW
authors.lastname: Shin
authors.forename: B Y
authors.initials: BY
authors.lastname: Hwang
authors.forename: D Y
authors.initials: DY
authors.lastname: Kwon
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019659:Asteraceae; D001426:Bacterial Proteins / Q000235:genetics; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D046915:Penicillin-Binding Proteins; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D016133:Polymerase Chain Reaction; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D046915:Penicillin-Binding Proteins; D010936:Plant Extracts; D012717:Sesquiterpenes; C521984:enhydrin; C487789:mecA protein, Staphylococcus aureus