title: [A retrospective study of clinical, histological, and immunological characteristics in patients with dermatitis herpetiformis. The experience of Hospital Clinic de Barcelona, Spain, between 1995 and 2010 and a review of the literature].
abstract: OBJECTIVE
  Dermatitis herpetiformis is a chronic bullous disease that is currently considered a cutaneous expression of gluten hypersensitivity. The aim of this study was to analyze and describe the clinical, histological, and immunopathological characteristics of patients with dermatitis herpetiformis assessed at Hospital Clinic de Barcelona, Spain between 1995 and 2010.
  
  
  METHODS
  Demographic, clinical, serologic, and histopathological data were reviewed for 33 patients with dermatitis herpetiformis.
  
  
  RESULTS
  The median age of the patients at the time of disease onset was 30 years and the majority were men. Associated autoimmune disease was present in 49% of patients. In 6 patients, celiac disease was diagnosed before dermatitis herpetiformis. Although excoriations were the most predominant lesions, 9 patients had blisters. Histological findings in skin lesions were compatible with dermatitis herpetiformis in 46% of cases. The most frequently observed staining pattern by indirect immunofluorescence was the presence of granular immunoglobulin A deposits in the basement membrane (62%). More than 80% of intestinal biopsies were compatible with celiac disease. Antibodies linked to gluten sensitivity were observed in 79% of patients. Only 1 malignant tumor was detected.
  
  
  CONCLUSIONS
  Notable findings were the frequent presence of bullous lesions, the high prevalence of celiac disease, and the positive findings on intestinal biopsy, all of which are suggestive of late diagnosis. Our findings confirm the lack of specificity of conventional histology in dermatitis herpetiformis and the association of the disease with other immunological disorders.
authors.affiliation: Servicio de Dermatología, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Fuertes
authors.forename: J M
authors.initials: JM
authors.lastname: Mascaró
authors.forename: J A
authors.initials: JA
authors.lastname: Bombí
authors.forename: P
authors.initials: P
authors.lastname: Iranzo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003874:Dermatitis Herpetiformis / Q000175:diagnosis* / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain; D013997:Time Factors; D055815:Young Adult