title: [Monitoring for influenza in population of Western Siberia in 2007-2009].
abstract: OBJECTIVE
  To analyze influenza viruses isolated in the 2008-2009 autumn-winter season, and to test sera collected in the south of Western Siberia during the beginning and the end of the epidemic seasons from 2007 until the A/H1N1 pandemic.
  
  
  METHODS
  Total 149 clinical samples were analyzed and 2190 blood sera were tested. During the 2008-2009 season 17 influenza viruses were isolated. 9 of these were A/H1N1, 5-were A/H3N2, and 3 were influenza B viruses. The nucleotide sequences and amino acid composition of influenza A virus hemagglutinin (HA) were compared with reference strains.
  
  
  RESULTS
  Among A/H1N1 viruses circulating in Novosibirsk region three viruses contained four amino acid replacements in antigen sites Ca, Cb and Sb. In A/ H3N2 viruses from Novosibirsk, 2 amino acid substitutions were detected in antigen sites B and E.
  
  
  CONCLUSIONS
  Based on genotyping influenzae epidemic on February to April of 2009 in the south of western Siberia was associated with influenza viruses A/H1N1, A/H3N2, and B. All A/H3N2 influenza virus isolates were variants of reference A/Brisbane/10/2007(H3N2) and A/ H1N1 influenza viruses isolates were similar to reference A/Brisbane/59/2007(H1N1).
authors.forename: T N
authors.initials: TN
authors.lastname: Il'icheva
authors.forename: A A
authors.initials: AA
authors.lastname: Romanovskaia
authors.forename: F A
authors.initials: FA
authors.lastname: Il'inykh
authors.forename: O G
authors.initials: OG
authors.lastname: Kurskaia
authors.forename: A G
authors.initials: AG
authors.lastname: Durymanov
authors.forename: M B
authors.initials: MB
authors.lastname: Ignashkina
authors.forename: M V
authors.initials: MV
authors.lastname: Kulak
authors.forename: E V
authors.initials: EV
authors.lastname: Ivanova
authors.forename: V S
authors.initials: VS
authors.lastname: Bespalov
authors.forename: L M
authors.initials: LM
authors.lastname: Gorbatovskaia
authors.forename: M V
authors.initials: MV
authors.lastname: Sivaĭ
authors.forename: A M
authors.initials: AM
authors.lastname: Shestopalov
authors.forename: E M
authors.initials: EM
authors.lastname: Malkova
authors.forename: I G
authors.initials: IG
authors.lastname: Drozdov
mesh_terms: D019943:Amino Acid Substitution; D004784:Environmental Monitoring; D058872:Epidemics; D062665:Epidemiological Monitoring; D005814:Genes, Viral / Q000235:genetics; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D053122:Influenza A Virus, H3N2 Subtype / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D009981:Influenza B virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D017720:Molecular Epidemiology; D016036:Seroepidemiologic Studies; D012800:Siberia / Q000453:epidemiology
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus