title: Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulation.
abstract: Interleukin-17 (IL-17) is a proinflammatory cytokine produced, although not exclusively, by T helper 17 recently identified as a distinct T helper lineage mediating tissue inflammation. IL-17 is known to be involved in a number of chronic disorders although the mechanisms regulating its production in inflammatory disease are still unclear. The beneficial properties of the polyphenolic compound resveratrol including its anti-inflammatory, antioxidant, and antitumor effects, its role in the aging process and in the prevention of heart and neurodegenerative diseases are well-known. In addition, derivatives of resveratrol, including glucosylated molecules as polydatin have been linked to similar beneficial effects. We have investigated the effects of resveratrol and polydatin on the in vitro production of IL-17 in a model of inflammation in vitro. The results obtained by activated human peripheral blood mononuclear cells, stimulated with anti-CD3/anti-CD28 monoclonal antibodies and treated with these polyphenolic compounds at different concentrations show that both decrease IL-17 production in a concentration-dependent manner. This study confirms the anti-inflammatory activity of resveratrol and its derivatives and suggests a potential clinical relevance in the therapy of inflammatory diseases.
authors.affiliation: Institute of Translational Pharmacology (IFT), National Council of Research, Rome, Via Fosso del Cavaliere 100, 00173, Rome, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Lanzilli
authors.forename: Andrea
authors.initials: A
authors.lastname: Cottarelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nicotera
authors.forename: Serena
authors.initials: S
authors.lastname: Guida
authors.forename: Giampiero
authors.initials: G
authors.lastname: Ravagnan
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Fuggetta
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D018106:CD28 Antigens / Q000276:immunology; D017252:CD3 Complex / Q000276:immunology; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology*; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018106:CD28 Antigens; D017252:CD3 Complex; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D020381:Interleukin-17; D012333:RNA, Messenger; D013267:Stilbenes; D000077185:Resveratrol; C058229:polydatin