title: Significance of adjunctive mitomycin C in endoscopic dacryocystorhinostomy.
abstract: OBJECTIVE
  The purpose of this study is to observe the effect of intraoperative topical application of mitomycin C (MMC) on the results of endoscopic dacryocystorhinostomy.
  
  
  METHODS
  This is a prospective, randomized, controlled, single-blind study.
  
  
  METHODS
  Hospitalized treatment was done in a tertiary medical college hospital and research center that deals with a predominantly rural population.
  
  
  METHODS
  Patients with primary acquired postsaccal obstruction causing chronic dacryocystitis were considered.
  
  
  METHODS
  A total of 38 patients were randomized into either a mitomycin group or a control group. Both of these groups were subjected to an identical surgical procedure, except that 0.2 mg/dL of MMC was used in the mitomycin group, whereas normal saline was used in the control group. The follow-up period was at least 6 months. An asymptomatic patient with a visible stoma at nasendoscopy and free flow of saline into the nose with lacrimal syringing after 6 months after surgery was used as criteria for defining a successful result.
  
  
  RESULTS
  The success rate was 82.3% when MMC was used and 85.7% among the controls (P > .05). Granulations, adhesions, and obliterative sclerosis occurred in a similar number of patients of both groups. However, granulations and adhesions did not have a bearing on the success rate in either group.
  
  
  CONCLUSIONS
  Mitomycin C did not appear to influence the occurrence of granulations, synechiae, or obliterative sclerosis, nor did it alter the success rate significantly.
authors.affiliation: Department of Otorhinolaryngology, R.L. Jalappa Hospital and Research Centre, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education, Tamaka, Kolar, India. drtpr@yahoo.com
authors.forename: Thomas
authors.initials: T
authors.lastname: Prasannaraj
authors.forename: B Y Praveen
authors.initials: BY
authors.lastname: Kumar
authors.forename: Indira
authors.initials: I
authors.lastname: Narasimhan
authors.forename: K V
authors.initials: KV
authors.lastname: Shivaprakash
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000477:Alkylating Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003607:Dacryocystitis / Q000188:drug therapy* / Q000601:surgery*; D003608:Dacryocystorhinostomy / Q000379:methods*; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D011446:Prospective Studies; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin