title: Antioxidative activity of microbial metabolites of (-)-epigallocatechin gallate produced in rat intestines.
abstract: The antioxidative activities of (-)-epigallocatechin gallate (EGCg) metabolites degraded by rat intestinal flora were investigated by a flow injection analysis coupled to an on-line antioxidant detection system with the 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation. All of the metabolites were found to have antioxidative activity, suggesting that the EGCg metabolites may show antioxidative activity in the body.
authors.affiliation: Laboratory of Tea Function R&D, Food Research Laboratories, Mitsui Norin Co., Ltd., Fujieda, Shizuoka, Japan. tgaki@mitsui-norin.co.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Takagaki
authors.forename: Shuichi
authors.initials: S
authors.lastname: Otani
authors.forename: Fumio
authors.initials: F
authors.lastname: Nanjo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D052160:Benzothiazoles / Q000378:metabolism; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D017022:Flow Injection Analysis; D016166:Free Radical Scavengers / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology; D007783:Lactones / Q000378:metabolism; D008827:Microbiological Phenomena; D051381:Rats; D013451:Sulfonic Acids / Q000378:metabolism; D013662:Tea / Q000737:chemistry
chemical_list: D000975:Antioxidants; D052160:Benzothiazoles; D016166:Free Radical Scavengers; D007783:Lactones; D013451:Sulfonic Acids; D013662:Tea; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D002392:Catechin; C045651:epigallocatechin gallate; C037556:gamma-valerolactone