title: Pure akinesia with low myocardial metaiodobenzylguanidine uptake.
abstract: The objective of this study was to delineate the clinical features of patients with pure akinesia and a low heart versus mediastinum ratio below 2.0 in the delayed images of myocardial metaiodobenzylguanidine scintigraphy, a marker for the clinical diagnosis of Lewy body diseases. A total of 13 patients was enrolled. The clinical features of the patients were uniformly elderly (mean age, 73.7 years), a male gender preponderance (10 men and 3 women), relatively mild motor disability (mean Hoehn Yahr grade 2.4) without laterality, festinating gait (77%) and loss of postural reflex (69%), which were the most common; also observed were fair levodopa responses (70%), cognitive dysfunction in some (23%), common autonomic dysfunction (urinary urgency and frequency, 85%; constipation, 77%; and postural hypotension, 38%) and common occipital hypoperfusion (62%). These features may facilitate the clinical differential diagnosis of these patients from patients with pure akinesia due to progressive supranuclear palsy.
authors.affiliation: Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura 285-8741, Japan.
authors.forename: Fuyuki
authors.initials: F
authors.lastname: Tateno
authors.forename: Ryuji
authors.initials: R
authors.lastname: Sakakibara
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kishi
authors.forename: Emina
authors.initials: E
authors.lastname: Ogawa
mesh_terms: D019797:3-Iodobenzylguanidine / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D009069:Movement Disorders / Q000000981:diagnostic imaging* / Q000473:pathology*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D019797:3-Iodobenzylguanidine