title: Preparation and application of hydrophilic monolithic columns.
abstract: Hydrophilic interaction chromatography (HILIC) has experienced increasing attention in recent years. Much research has been carried out in the area of HILIC separation mechanisms, column techniques and applications. Because of their good permeability, low resistance to mass transfer and easy preparation within capillaries, hydrophilic monolithic columns represent a trend among novel HILIC column techniques. This review attempts to present an overview of the preparation and applications of HILIC monolithic columns carried out in the past decade. The separation mechanism of various hydrophilic monolithic stationary phases is also reviewed.
authors.affiliation: Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou, China. jzjjackson@hotmail.com
authors.forename: Zhengjin
authors.initials: Z
authors.lastname: Jiang
authors.forename: Norman William
authors.initials: NW
authors.lastname: Smith
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Liu
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D011108:Polymers / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D011108:Polymers; D012822:Silicon Dioxide