title: Fulminating septicemia due to persistent pan-resistant community-acquired metallo-β-lactamase (IMP-1)-positive Acinetobacter baumannii.
abstract: Acinetobacter baumannii is considered as an emerging nosocomial pathogen and is renowned for its multi-drug resistance. We report a case of community-acquired pan-resistant A. baumannii caused fulminating septicemia. The treatment failure led to death. The A. baumannii strain isolated from blood, pus, urine and tracheal aspirate was confirmed by 16S r-RNA sequence homology and found positive for metallo-β-lactamase IMP-1, and was found to be a strong biofilm producer. The isolate was only susceptible (moderately) to colistin.
authors.affiliation: College of Medicine, Drexel University, Philadelphia, PA 19102, USA.
authors.forename: Nilima V
authors.initials: NV
authors.lastname: Telang
authors.forename: Meenakshi G
authors.initials: MG
authors.lastname: Satpute
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Dhakephalkar
authors.forename: Krishna B
authors.initials: KB
authors.lastname: Niphadkar
authors.forename: Suresh G
authors.initials: SG
authors.lastname: Joshi
mesh_terms: D000151:Acinetobacter Infections / Q000175:diagnosis* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001769:Blood / Q000382:microbiology; D017714:Community-Acquired Infections / Q000175:diagnosis* / Q000382:microbiology; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D018805:Sepsis / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D013492:Suppuration / Q000382:microbiology; D014132:Trachea / Q000382:microbiology; D014556:Urine / Q000382:microbiology; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S; C409201:beta-lactamase IMP-1; D001618:beta-Lactamases