title: Metastatic osteosarcoma presenting as a single pulmonary microembolus.
abstract: There are only a few published reports of tumor emboli from osteosarcoma. We are reporting a 17-year-old adolescent boy with a history of localized osteosarcoma who developed a symptomatic pulmonary artery tumor embolus. He was initially diagnosed with a pulmonary thromboembolism. This is the first reported case of a single tumor embolus developing after surgical resection of a tumor with 100% necrosis after chemotherapy and no evidence of metastatic disease at the time of surgery. Pulmonary tumor embolism should be considered in the differential diagnosis in patients with cancer who present with dyspnea. The differentiation of tumor embolus from other causes of dyspnea is important for treatment plan.
authors.affiliation: Department of Surgery, The Mount Sinai Medical Center, New York, NY 10029, USA. mark.shapiro@mssm.edu
authors.forename: Mark
authors.initials: M
authors.lastname: Shapiro
authors.forename: Birte
authors.initials: B
authors.lastname: Wistinghausen
authors.forename: Peter
authors.initials: P
authors.lastname: Midulla
authors.forename: Cynthia
authors.initials: C
authors.lastname: Chin
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D017984:Enoxaparin / Q000627:therapeutic use; D005047:Etoposide / Q000008:administration & dosage; D005266:Femoral Neoplasms / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D023821:Limb Salvage; D008297:Male; D009360:Neoplastic Cells, Circulating; D012516:Osteosarcoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D011013:Pneumonectomy / Q000379:methods; D011183:Postoperative Complications / Q000175:diagnosis*; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000473:pathology; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D013923:Thromboembolism / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D005047:Etoposide; D007069:Ifosfamide