title: Histone H4 acetylation by immunohistochemistry and prognosis in relapsed acute lymphocytic leukaemia (ALL).
abstract: Histone H4 acetylation was examined by immunohistochemistry in patients with acute lymphocytic leukaemia (ALL) in first relapse. Univariate and multivariate models identified correlates of complete remission (CR) and overall survival (OS). No variables were associated with achievement of CR. In multivariate analysis, weak histone H4 acetylation [Hazard Ratio (HR) 2·20, 95% confidence interval (CI) 0·93-5·23, P=0·07], shorter interval from diagnosis to relapse (<9 vs. 9-24 vs. >24 months) (HR 1·82, 95% CI 1·20-2·75, P= 0·005), and central nervous system involvement (HR 3·43, 95% CI 1·31-8·99, P=0·01) were independent poor prognostic factors for OS. These data provide a rationale for the use of histone deacetylase inhibitors in the treatment of relapsed ALL.
authors.affiliation: Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, OH 44195, USA. advania@ccf.org
authors.forename: Anjali S
authors.initials: AS
authors.lastname: Advani
authors.forename: Sarah
authors.initials: S
authors.lastname: Gibson
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Douglas
authors.forename: Julia
authors.initials: J
authors.lastname: Diacovo
authors.forename: Paul
authors.initials: P
authors.lastname: Elson
authors.forename: Matt
authors.initials: M
authors.lastname: Kalaycio
authors.forename: Ed
authors.initials: E
authors.lastname: Copelan
authors.forename: Mikkael
authors.initials: M
authors.lastname: Sekeres
authors.forename: Ronald
authors.initials: R
authors.lastname: Sobecks
authors.forename: Shawnda
authors.initials: S
authors.lastname: Sungren
authors.forename: Anand
authors.initials: A
authors.lastname: Lagoo
authors.forename: David
authors.initials: D
authors.lastname: Rizzieri
authors.forename: Eric
authors.initials: E
authors.lastname: Hsi
mesh_terms: D000107:Acetylation; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D004812:Epidemiologic Methods; D005260:Female; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*; D011379:Prognosis; D012008:Recurrence; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D006657:Histones