title: On emerging nuclear order.
abstract: Although the nonrandom nature of interphase chromosome arrangement is widely accepted, how nuclear organization relates to genomic function remains unclear. Nuclear subcompartments may play a role by offering rich microenvironments that regulate chromatin state and ensure optimal transcriptional efficiency. Technological advances now provide genome-wide and four-dimensional analyses, permitting global characterizations of nuclear order. These approaches will help uncover how seemingly separate nuclear processes may be coupled and aid in the effort to understand the role of nuclear organization in development and disease.
authors.affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors.forename: Indika
authors.initials: I
authors.lastname: Rajapakse
authors.forename: Mark
authors.initials: M
authors.lastname: Groudine
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure*; D042002:Chromatin Assembly and Disassembly; D002875:Chromosomes / Q000502:physiology / Q000648:ultrastructure; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D007399:Interphase; D042581:Intranuclear Space / Q000648:ultrastructure*; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics; D014178:Translocation, Genetic