title: Endothelin-1 in peripheral arterial disease: a potential role in muscle damage.
abstract: The evidence for the role of endothelin-1 (ET-1) in endothelial dysfunction and atherosclerosis has been growing since its discovery. However most studies have focussed on cardiac disease and its role in peripheral arterial disease (PAD) is less clear. In addition to its role in the development and progression of atherosclerotic lesions in lower limb arteries, there is evidence that ET-1 adversely affects microvessels within the muscle and the viability of the ischemic muscle itself. This review summarises some of these findings which underscore the potential use of ET antagonists as an adjunct in the treatment of PAD.
authors.affiliation: Division of Surgery and Interventional Science, University College London, Royal Free Campus, Pond Street, London NW32QG, UK. j.tsui@medsch.ucl.ac.uk
authors.forename: Janice C
authors.initials: JC
authors.lastname: Tsui
authors.forename: Xu
authors.initials: X
authors.lastname: Shi-Wen
mesh_terms: D001158:Arteries / Q000378:metabolism / Q000503:physiopathology*; D019332:Endothelin-1 / Q000502:physiology*; D006801:Humans; D055806:Microvessels / Q000378:metabolism / Q000503:physiopathology; D018485:Muscle Fibers, Skeletal / Q000378:metabolism / Q000502:physiology; D058729:Peripheral Arterial Disease / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D019332:Endothelin-1