title: Dinuclear zinc catalyzed asymmetric Friedel-Crafts amidoalkylation of indoles with aryl aldimines.
abstract: The asymmetric Friedel-Crafts amidoalkylation of indoles with aryl aldimines could be efficiently catalyzed by Trost's bis-ProPhenol dinuclear zinc complexes to attain 3-indolyl methanamine derivatives in good to excellent yields (85-98%) with moderate to high enantiomeric ratios (from 70 : 30 up to 95 : 5 er). Remarkably, this approach provides efficient access to enantiomerically enriched 3-indolyl methanamines, which avoids the formation of the undesirable bis- and tris(indolyl)methanes (BIMs and TIMs) byproduct.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
authors.forename: Bei-Lei
authors.initials: BL
authors.lastname: Wang
authors.forename: Nai-Kai
authors.initials: NK
authors.lastname: Li
authors.forename: Jin-Xin
authors.initials: JX
authors.lastname: Zhang
authors.forename: Guo-Gui
authors.initials: GG
authors.lastname: Liu
authors.forename: Teng
authors.initials: T
authors.lastname: Liu
authors.forename: Qi
authors.initials: Q
authors.lastname: Shen
authors.forename: Xing-Wang
authors.initials: XW
authors.lastname: Wang