title: Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex.
abstract: Memories are more easily disrupted than improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium of potential memory enhancers is so far rather modest. Moreover, the effect of the latter appears to be limited to enhancing new memories during encoding and the initial period of cellular consolidation, which can last from a few minutes to hours after learning. Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mζ (PKMζ) enhances long-term memory, whereas a dominant negative PKMζ disrupts memory, even long after memory has been formed.
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Reut
authors.initials: R
authors.lastname: Shema
authors.forename: Sharon
authors.initials: S
authors.lastname: Haramati
authors.forename: Shiri
authors.initials: S
authors.lastname: Ron
authors.forename: Shoshi
authors.initials: S
authors.lastname: Hazvi
authors.forename: Alon
authors.initials: A
authors.lastname: Chen
authors.forename: Todd Charlton
authors.initials: TC
authors.lastname: Sacktor
authors.forename: Yadin
authors.initials: Y
authors.lastname: Dudai
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological; D015870:Gene Expression; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D016086:Lentivirus / Q000235:genetics; D008297:Male; D057567:Memory, Long-Term; D050505:Mutant Proteins / Q000378:metabolism; D009154:Mutation; D019579:Neocortex / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D011493:Protein Kinase C / Q000235:genetics* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007527:Isoenzymes; D050505:Mutant Proteins; D011493:Protein Kinase C; C504730:protein kinase M zeta, rat