title: Dose assessment of 2% chlorhexidine acetate for canine superficial pyoderma.
abstract: The dose of 2% chlorhexidine acetate (2CA; Nolvasan(®) Surgical Scrub; Fort Dodge Animal Health, Fort Dodge, IA, USA) for canine superficial pyoderma was evaluated. The first trial compared three doses (group 1, 57 mL/m(2) body surface area; group 2, 29 mL/m(2) body surface area; and group 3, 19 mL/m(2) body surface area) in a randomized, double-blind, controlled fashion. Twenty-seven dogs with superficial pyoderma were treated with 2CA at the allocated doses every 2 days for 1 week. The owners and investigators subjectively evaluated the dogs, and investigators scored skin lesions, including erythema, papules/pustules, alopecia and scales, on a 0-4 scale. There were no significant differences in response between the treatment groups. The second trial established a practical dose-measuring method for 2CA. Sixty-eight owners were asked to apply 2CA on their palm in an amount corresponding to a Japanese ¥500 coin, 26.5 mm in diameter. This yielded an average dose of 0.90±0.40 mL. Mathematically, the doses used in groups 1, 2 and 3 can be represented as one coin per approximately one-, two- and three-hand-sized lesions, respectively. The results therefore suggest that owners instructed to apply one coin of the product per two-hand-sized areas of superficial pyoderma would use the range of doses evaluated in this trial.
authors.affiliation: ASC Dermatology Service, Tokyo, Japan. murayama@asc.jp
authors.forename: Nobuo
authors.initials: N
authors.lastname: Murayama
authors.forename: Yuri
authors.initials: Y
authors.lastname: Terada
authors.forename: Mio
authors.initials: M
authors.lastname: Okuaki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nagata
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D011711:Pyoderma / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D002710:Chlorhexidine