title: Hematological and serum biochemical indices in healthy bonnet macaques (Macaca radiata).
abstract: BACKGROUND
  Blood reference values for bonnet macaques (Macaca radiata) are limited. The goal of this study was to determine reference ranges for hematological and serum biochemical indices in healthy, socially housed bonnet macaques for males and females over a range of ages.
  
  
  METHODS
  Blood hematological and serum biochemical values were obtained from 50 healthy bonnet macaques of both sexes and aged 10-234 months.
  
  
  RESULTS
  Age and sex differences were present in a number of measures. Globulins, total protein, and creatinine (CREAT) values were highest among older subjects, while alkaline phophatase, albumin, and phosphorus values were higher in juveniles. Sex differences were present in concentrations of red blood cells and CREAT, with higher values in males.
  
  
  CONCLUSIONS
  The blood parameter data reported here as age-specific reference values for laboratory-housed, healthy bonnet macaques may be used to inform clinical care and laboratory primate research.
authors.affiliation: Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Pierre
authors.forename: Marlon K
authors.initials: MK
authors.lastname: Sequeira
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Corcoran
authors.forename: Maria W
authors.initials: MW
authors.lastname: Blevins
authors.forename: Melaney
authors.initials: M
authors.lastname: Gee
authors.forename: Mark L
authors.initials: ML
authors.lastname: Laudenslager
authors.forename: Allyson J
authors.initials: AJ
authors.lastname: Bennett
mesh_terms: D000375:Aging / Q000097:blood; D000418:Albumins / Q000032:analysis; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000830:Animals, Laboratory; D001774:Blood Chemical Analysis / Q000662:veterinary*; D001798:Blood Proteins / Q000032:analysis; D003404:Creatinine / Q000097:blood; D004906:Erythrocyte Count / Q000662:veterinary; D005260:Female; D005916:Globulins / Q000032:analysis; D008255:Macaca radiata / Q000097:blood*; D008297:Male; D009657:North Carolina; D010758:Phosphorus / Q000097:blood; D012016:Reference Values; D012727:Sex Characteristics
chemical_list: D000418:Albumins; D001798:Blood Proteins; D005916:Globulins; D010758:Phosphorus; D003404:Creatinine; D000469:Alkaline Phosphatase