title: A PVA/PVP hydrogel for human lens substitution: Synthesis, rheological characterization, and in vitro biocompatibility.
abstract: To overcome opacification and absence of accommodation of human lens substitutes a new poly(vinyl alcohol) (PVA)/poly(N-vinyl-2- pyrrolidinone) (PVP) based hydrogel (PPS31075) was realised. The Infrared Spectroscopy and the mechanical spectra confirmed the successful occurrence of crosslinking reaction. The rheological analysis pointed out a behavior comparable with that of young human lens in terms of complex shear modulus and accommodation capability. Further analysis in terms of optical properties, water content measurements, diffusion coefficient, cytotoxicity, and human capsular cell adhesion confirmed the applicability of such a hydrogel as potential human lens substitute.
authors.affiliation: Department of Pharmaceutical and Applied Chemistry, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. leone10@unisi.it
authors.forename: Gemma
authors.initials: G
authors.lastname: Leone
authors.forename: Marco
authors.initials: M
authors.lastname: Consumi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Greco
authors.forename: Claudia
authors.initials: C
authors.lastname: Bonechi
authors.forename: Stefania
authors.initials: S
authors.lastname: Lamponi
authors.forename: Claudio
authors.initials: C
authors.lastname: Rossi
authors.forename: Agnese
authors.initials: A
authors.lastname: Magnani
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007908:Lens, Crystalline; D008422:Materials Testing / Q000379:methods; D015394:Molecular Structure; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D012212:Rheology; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020100:Hydrogels; D014867:Water; D011142:Polyvinyl Alcohol; D011205:Povidone