title: Seroprevalence of anti-Helicobacter pylori and anticytotoxin-associated gene A antibodies [corrected] according to ABO blood groups and rhesus status among hemodialysis patients.
abstract: BACKGROUND
  Correlation between Helicobacter pylori infection and blood group typing has been widely evaluated in both patients and healthy population. However, data addressing this correlation in hemodialysis patients are scarce. The aim of this study was to evaluate the prevalence of anti-Helicobacter pylori and anticytotoxin-associated gene A (anti-Cag A) antigen antibodies and their correlations with ABO blood groups and rhesus blood group status in hemodialysis patients. MATERIALS AND METHODS; In a cross-sectional study, serum samples of 151 hemodialysis patients were tested for anti-Helicobacter pylori IgG antibody. Anti-Cag A antibody (IgG antibody) was tested in Helicobacter pylori-positive patients. ABO blood groups typing and rhesus status were tested by hemagglutination test.
  
  
  RESULTS
  Prevalence of anti-Helicobacter pylori and anti-Cag A antibodies in Helicobacter pylori-positive patients were 65.6% (99 of 151) and 25.3% (25 of 99), respectively. Prevalence of anti-Helicobacter pylori and anti-Cag A antibodies were 69.1% and 36.8% in patients with blood group A, 42.3% and 9.1% in blood group B, 75.0 % and zero in blood group AB, 69.4% and 23.3% in blood group O, 59.0% and 30.6% in rhesus-positive status and 89.7% and 11.5% in rhesus-negative status, respectively. There was a significant correlation between the presence of anti-Helicobacter pylori and anti-Cag A antibodies and rhesus status, but no significant relation between ABO blood groups and anti-Cag A antibodies were found.
  
  
  CONCLUSIONS
  Rhesus status may have an impact on the presence of anti-Helicobacter pylori and anti-Cag A antibodies. More investigations to address this correlation are necessary.
authors.affiliation: Department of Biochemistry, Urmia University of Medical Sciences, Urmia, Iran. yr1350@yahoo.com
authors.forename: Yousef
authors.initials: Y
authors.lastname: Rasmi
authors.forename: Khadijeh
authors.initials: K
authors.lastname: Makhdoomi
authors.forename: Saman
authors.initials: S
authors.lastname: Farshid
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Kheradmand
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000368:Aged; D000936:Antigen-Antibody Complex / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D003430:Cross-Sectional Studies; D005260:Female; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D016036:Seroepidemiologic Studies
chemical_list: D000017:ABO Blood-Group System; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D012204:Rh-Hr Blood-Group System; C080866:cagA protein, Helicobacter pylori