title: New S-benzylisothiosemicarbazones with antimycobacterial activity.
abstract: Benzaldehyde- and salicylaldehyde-S-benzylisothiosemicarbazones show a moderate to high in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. Benzaldehyde-S-4-bromobenzylisothiosemicarbazone and salicylaldehyde-S-4-chlorobenzylisothiosemicarbazone have the most promising antimycobacterial properties.
authors.affiliation: Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, 500 05, Hradec Králové, Czech Republic. Eva.Petrlikova@faf.cuni.cz
authors.forename: E
authors.initials: E
authors.lastname: Petrlíková
authors.forename: K
authors.initials: K
authors.lastname: Waisser
authors.forename: L
authors.initials: L
authors.lastname: Heinisch
authors.forename: J
authors.initials: J
authors.lastname: Stolaříková
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009162:Mycobacterium avium / Q000187:drug effects*; D019909:Mycobacterium kansasii / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000737:chemistry / Q000494:pharmacology*; D014376:Tuberculosis / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D010636:Phenols; D013882:Thiosemicarbazones