title: Metabolic myopathies: functional evaluation by different exercise testing approaches.
abstract: Metabolic myopathies are a clinically and etiologically heterogeneous group of disorders due to defects in muscular energy metabolism. They include glycogen storage diseases, fatty acid oxidation defects, and mitochondrial disorders. The typical manifestations of a metabolic myopathy are exercise-induced myalgias, exercise intolerance, and cramps. Evaluating subjects with such symptoms is not easy because of the frequent lack of clinical features. Exercise tests are, therefore, reliable screening tools. Here, we discuss the possible role of such exercise testing techniques in the diagnostic approach of a patient with suspected metabolic myopathy.
authors.affiliation: Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Volpi
authors.forename: G
authors.initials: G
authors.lastname: Ricci
authors.forename: D
authors.initials: D
authors.lastname: Orsucci
authors.forename: R
authors.initials: R
authors.lastname: Alessi
authors.forename: F
authors.initials: F
authors.lastname: Bertolucci
authors.forename: S
authors.initials: S
authors.lastname: Piazza
authors.forename: C
authors.initials: C
authors.lastname: Simoncini
authors.forename: M
authors.initials: M
authors.lastname: Mancuso
authors.forename: G
authors.initials: G
authors.lastname: Siciliano
mesh_terms: D000465:Algorithms; D015444:Exercise; D005080:Exercise Test / Q000009:adverse effects*; D005542:Forearm / Q000098:blood supply*; D006008:Glycogen Storage Disease / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D052439:Lipid Metabolism Disorders / Q000175:diagnosis / Q000378:metabolism; D008659:Metabolic Diseases / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism* / Q000503:physiopathology; D028361:Mitochondrial Diseases / Q000175:diagnosis / Q000378:metabolism; D009135:Muscular Diseases / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity