title: Bojanggunbi-tang, a traditional Korean herbal prescription, ameliorates colonic inflammation induced by dextran sulfate sodium and 2,4,6-trinitrobenzene sulfonic acid in mice.
abstract: BACKGROUND
  In traditional Korean medicine, Bojanggunbi-tang (BGT), which consists of 16 herbs, is one of the most frequently used herbal prescriptions in South Korea for treating intestinal disorders such as colitis.
  
  
  OBJECTIVE
  This study investigated whether BGT could show a protective action on 2 different mice models of experimental colitis induced by dextran sulfate sodium (DSS) and 2,4,6-trinitrobenzene sulfonic acid (TNBS), which have been popularly used as inflammatory bowel disease models.
  
  
  METHODS
  Colitis was induced by DSS and TNBS in institute of cancer research mice. BGT at doses of 50, 150, or 450 mg/kg were orally administered twice a day for 7d in the DSS model and for 3d in the TNBS model. The body weight of the mice was measured daily. Colon length and histological damages were assessed on day 7 in the DSS model and on day 3 in the TNBS model.
  
  
  RESULTS
  BGT showed protective effects in both types of experimental colitis. In the DSS model, BGT dose dependently inhibited weight loss, shortening of colon length, and histological damages of the colon. In the TNBS model, BGT inhibited shortening of colon length and improved the survival rate of mice; however, it did not inhibit weight loss.
  
  
  CONCLUSIONS
  The current results indicate that BGT ameliorates both DSS- and TNBS-induced colitis in mice. Further investigations to unveil the exact mechanisms are needed.
authors.affiliation: Department of Gastroenterology, College of Oriental Medicine, Kyung Hee University, 1 Heogi-dong, Dongdaemun-gu, Seoul 103-701, Republic of Korea.
authors.forename: Bongha
authors.initials: B
authors.lastname: Ryu
authors.forename: Wooseong
authors.initials: W
authors.lastname: Ro
authors.forename: Jae-Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Youngmin
authors.initials: Y
authors.lastname: Bu
authors.forename: Beom-Joon
authors.initials: BJ
authors.lastname: Lee
authors.forename: Sungjik
authors.initials: S
authors.lastname: Lim
authors.forename: Jinsung
authors.initials: J
authors.lastname: Kim
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Yoon
mesh_terms: D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy*; D016264:Dextran Sulfate / Q000009:adverse effects*; D008519:Medicine, Traditional; D051379:Mice; D014302:Trinitrobenzenesulfonic Acid / Q000009:adverse effects*
chemical_list: D014302:Trinitrobenzenesulfonic Acid; D016264:Dextran Sulfate