title: Evaluation of oxidant and antioxidant status in infants with hyperbilirubinemia and kernicterus.
abstract: OBJECTIVE
  The objective of the present study was to determine oxidant and antioxidant status in infants with hyperbilirubinemia and/or kernicterus and to find whether there is a relationship between bilirubin level and oxidant/antioxidant status.
  
  
  METHODS
  The study includes 69 full-term newborns (neonates with hyperbilirubinemia needing phototherapy [Group 1, n = 36] and neonates with kernicterus [Group 2, n = 33]) and 25 age-matched healthy newborn.
  
  
  RESULTS
  Plasma total antioxidant capacity (TAC) and serum total oxidant status (TOS) were significantly higher in Groups 1 and 2 than the control group. There was a significant difference between Group 1 and control cases for malondialdehyde (MDA; p < 0.001). Total free sulfhydryl group (TTHI) values were significantly elevated in Group 1 compared to Group 2 and control cases. Correlation analysis showed that the correlation between total bilirubin (TB) and TAC, TOS, MDA and oxidative stress index may be expressed by a quadratic curve. After phototherapy, a statistically significant increase in nitrite level was observed.
  
  
  CONCLUSIONS
  We demonstrated that the relationship between serum TB and antioxidants and oxidative stress could be expressed by a quadratic correlation curve.
authors.affiliation: Department of Pediatrics, School of Medicine, Yuzuncu Yil University, Van, Turkey. doganmurat.md@gmail.com
authors.forename: Murat
authors.initials: M
authors.lastname: Doğan
authors.forename: Erdal
authors.initials: E
authors.lastname: Peker
authors.forename: Ercan
authors.initials: E
authors.lastname: Kirimi
authors.forename: Ertan
authors.initials: E
authors.lastname: Sal
authors.forename: Sinan
authors.initials: S
authors.lastname: Akbayram
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Ocak
authors.forename: Oguz
authors.initials: O
authors.lastname: Tuncer
mesh_terms: D001663:Bilirubin / Q000097:blood*; D001772:Blood Cell Count; D016022:Case-Control Studies; D002839:Chromans / Q000097:blood; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D006932:Hyperbilirubinemia / Q000097:blood*; D007231:Infant, Newborn; D007647:Kernicterus / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D010789:Phototherapy; D013438:Sulfhydryl Compounds / Q000097:blood
chemical_list: D002839:Chromans; D009566:Nitrates; D009573:Nitrites; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D001663:Bilirubin; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid