title: Single-dose pharmacokinetics of oxytetracycline and penicillin G in tammar wallabies (Macropus eugenii).
abstract: The pharmacokinetics of oxytetracycline and penicillin G was investigated in tammar wallabies (Macropus eugenii). Groups of eight healthy tammar wallabies were administered i.v. oxytetracycline hydrochloride (40 mg/kg), i.m. long-acting-oxytetracycline (20 mg/kg), i.v. sodium penicillin G (30 mg/kg), or i.m. procaine/benzathine penicillin G (30 mg/kg). Plasma concentrations of oxytetracycline were determined using high-performance liquid chromatography. Pharmacokinetic parameters were comparable to those reported for eutherians of equivalent size and suggest that the practice of adjusting allometrically scaled doses to account for the lower metabolic rate of marsupials may not be valid. Long-acting oxytetracycline and penicillin G both demonstrated depot effects. However, the plasma concentrations achieved question the therapeutic efficacy of the long-acting preparations.
authors.affiliation: Ontario Veterinary College, University of Guelph, Guelph, ON, Canada. dmclelland@zoossa.com.au
authors.forename: D J
authors.initials: DJ
authors.lastname: McLelland
authors.forename: I K
authors.initials: IK
authors.lastname: Barker
authors.forename: G
authors.initials: G
authors.lastname: Crawshaw
authors.forename: L A
authors.initials: LA
authors.lastname: Hinds
authors.forename: L
authors.initials: L
authors.lastname: Spilsbury
authors.forename: R
authors.initials: R
authors.lastname: Johnson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D018592:Cross-Over Studies; D004734:Energy Metabolism; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D007614:Macropodidae / Q000378:metabolism*; D008297:Male; D010118:Oxytetracycline / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010400:Penicillin G / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011897:Random Allocation
chemical_list: D000900:Anti-Bacterial Agents; D010400:Penicillin G; D010118:Oxytetracycline