title: Involvement of oxidative stress and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in inflammatory bowel disease.
abstract: The pathophysiology of inflammatory bowel disease involves excessive immune effects of inflammatory cells against gut microbes. In genetically predisposed individuals, these effects are considered to contribute to the initiation and perpetuation of mucosal injury. Oxidative stress is a fundamental tissue-destructive mechanisms that can occur due to the reactive oxygen species and reactive nitrogen metabolites which are released in abundance from numerous inflammatory cells that have extravasated from lymphatics and blood vessels to the lamina propria. This extravasation is mediated by interactions between adhesion molecules including mucosal addressin cell adhesion molecule-1 and vascular cell adhesion molecule-1 on the surface of lymphocytes or neutrophils and their ligands on endothelial cells. Thus, reactive oxygen species and adhesion molecules play an important role in the development of inflammatory bowel disease. The present review focuses on the involvement of oxidative stress and adhesion molecules, in particular mucosal addressin cell adhesion molecule-1, in inflammatory bowel disease.
authors.affiliation: Department of Gastroenterology and Metabolism, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho, Nagoya, Aichi 467-8601, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanida
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Mizoshita
authors.forename: Takashi
authors.initials: T
authors.lastname: Mizushima
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Takaya
authors.initials: T
authors.lastname: Shimura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamiya
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Takashi
authors.initials: T
authors.lastname: Joh