title: Influencing the Wnt signaling pathway in multiple myeloma.
abstract: Recent studies have implicated genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway and thus influencing the initiation and progression of multiple myeloma (MM). Of major importance, these findings may lead to novel treatment strategies exploiting targeted modulation of Wnt signaling. This review describes the current status of knowledge concerning the role of Wnt pathway alteration in MM and outlines future lines of research and their clinical perspectives.
authors.affiliation: Department of Internal Medicine III, Center for Integrated Oncology, University of Bonn, Germany. Ingo.Schmidt-Wolf@ukb.uni-bonn.de
authors.forename: Young
authors.initials: Y
authors.lastname: Kim
authors.forename: Guido
authors.initials: G
authors.lastname: Reifenberger
authors.forename: Desheng
authors.initials: D
authors.lastname: Lu
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Endo
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Carson
authors.forename: Sanna-Marie
authors.initials: SM
authors.lastname: Gast
authors.forename: Karoline
authors.initials: K
authors.lastname: Meschenmoser
authors.forename: Michael
authors.initials: M
authors.lastname: Nowak
authors.forename: Ingo G H
authors.initials: IG
authors.lastname: Schmidt-Wolf
mesh_terms: D006801:Humans; D058990:Molecular Targeted Therapy; D009101:Multiple Myeloma / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism
chemical_list: D051153:Wnt Proteins; D051176:beta Catenin