title: Neonatal medical admission in a term and late-preterm cohort exposed to magnesium sulfate.
abstract: OBJECTIVE
  The purpose of this study was to estimate neonatal intensive care unit and special care unit (NICU) admission rates and care needs among term and late-preterm neonates who are exposed to antenatal magnesium sulfate.
  
  
  METHODS
  We conducted a retrospective cohort study of all singleton neonates of ≥35 weeks' gestation who were exposed immediately antenatally to magnesium sulfate for maternal eclampsia prophylaxis (August 2006 through July 2008).
  
  
  RESULTS
  Fifty-one of 242 neonates (21.1%) who, at ≥35 weeks' gestation, had been exposed to antenatal magnesium sulfate were admitted to the NICU. NICU admission was associated in a dose-dependent fashion with total hours and mean dose of magnesium: >12 hours exposure, odds ratio, 2.81 (95% confidence interval, 1.31-6.03); >30 g exposure, odds ratio, 2.59 (95% confidence interval, 1.22-5.51). Infants in NICU who were diagnosed with hypermagnesemia required fluid or nutritional support more frequently (91.3% vs 39.3%; P < .001) than those without hypermagnesemia.
  
  
  CONCLUSIONS
  Antenatal magnesium sulfate exposure is associated with NICU admission among term and late-preterm neonates in a dose-dependent fashion. Fluid and nutritional assistance commonly are needed in this cohort.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University, CA, USA.
authors.forename: Mara B
authors.initials: MB
authors.lastname: Greenberg
authors.forename: Anna A
authors.initials: AA
authors.lastname: Penn
authors.forename: Lewis J
authors.initials: LJ
authors.lastname: Thomas
authors.forename: Yasser Y
authors.initials: YY
authors.lastname: El-Sayed
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Caughey
authors.forename: Deirdre J
authors.initials: DJ
authors.lastname: Lyell
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data*; D008278:Magnesium Sulfate / Q000009:adverse effects*; D008297:Male; D008431:Maternal-Fetal Exchange; D010343:Patient Admission / Q000706:statistics & numerical data*; D011247:Pregnancy; D012189:Retrospective Studies; D047929:Term Birth
chemical_list: D008278:Magnesium Sulfate