title: Fibrin-polyethylene oxide interpenetrating polymer networks: new self-supported biomaterials combining the properties of both protein gel and synthetic polymer.
abstract: Interpenetrating polymer network (IPN) architectures were conceived to improve the mechanical properties of a fibrin gel. Conditions allowing an enzymatic reaction to create one of the two networks in IPN architecture were included in the synthesis pathway. Two IPN series were carried out, starting from two polyethylene oxide (PEO) network precursors leading to different cross-linking densities of the PEO phase. The fibrin concentration varied from 5 to 20 wt.% in each series. The behavior of these materials during dehydration/hydration cycles was also studied. The mechanical properties of the resulting IPN were characterized in the wet and dry states. These self-supported biomaterials combine the properties of both a protein gel and a synthetic polymer. Finally, cells were grown on PEO/fibrin IPN, indicating that they are non-cytotoxic.
authors.affiliation: Equipe de Recherche sur les Relations Matrice Extracellulaire Cellules (Errmece), Institut des Matériaux, Cergy-Pontoise University, 95000 Cergy-Pontoise, France.
authors.forename: E
authors.initials: E
authors.lastname: Akpalo
authors.forename: L
authors.initials: L
authors.lastname: Bidault
authors.forename: M
authors.initials: M
authors.lastname: Boissière
authors.forename: C
authors.initials: C
authors.lastname: Vancaeyzeele
authors.forename: O
authors.initials: O
authors.lastname: Fichet
authors.forename: V
authors.initials: V
authors.lastname: Larreta-Garde
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005337:Fibrin / Q000737:chemistry*; D005782:Gels; D011092:Polyethylene Glycols / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D055682:Viscoelastic Substances
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D011506:Proteins; D055682:Viscoelastic Substances; D011092:Polyethylene Glycols; D005337:Fibrin