title: Alcohol-dehydrogenase (ADH1B) Arg48His polymorphism in Basque Country patients with oral and laryngeal cancer: preliminary study.
abstract: Oral and laryngeal cancer has a high incidence in the Basque Country (Spain), the main risk factors in this pathology being regular consumption of tobacco and alcohol. However, since not all the individuals exposed to these risk factors develop cancer, the individual genetic susceptibility should be investigated in this population. The aim of this study was to determine the distribution of alcohol dehydrogenase-1B polymorphism (Arg48His; rs1229984) in our region and analyze its association with the risk of oral and laryngeal squamous cell carcinoma. Samples from 87 patients with oral or laryngeal cancer and 242 healthy controls were analyzed. Multivariate logistic regression analysis showed that the combined Arg/His and His/His genotypes were associated with a reduced risk of head and neck squamous cell carcinoma (odds ratio: 0.203; 95% confidence interval: 0.052-0.796). In conclusion, the histidine allele was associated with a reduced risk of oral and laryngeal cancer in the Basque Country.
authors.affiliation: Oral Medicine and Pathology Unit, Faculty of Medicine and Dentistry, University of the Basque Country UPV/EHU, Leioa, Spain.
authors.forename: Xabier
authors.initials: X
authors.lastname: Marichalar-Mendia
authors.forename: Amelia
authors.initials: A
authors.lastname: Acha-Sagredo
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Rodriguez-Tojo
authors.forename: Natalia
authors.initials: N
authors.lastname: Rey-Barja
authors.forename: Miriam
authors.initials: M
authors.lastname: Hernando-Rodriguez
authors.forename: Jose Ignacio
authors.initials: JI
authors.lastname: Aguirregaviria
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Aguirre-Urizar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013030:Spain / Q000453:epidemiology
chemical_list: C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase