title: Suppression of oral tolerance by Lactococcus lactis in mice.
abstract: Although oral ovabumin (OVA) administration suppressed the antibody (Ab) response in OVA-immunized mice, Lactococcus lactis increased OVA-specific IgG2a in these mice. L. lactis increased the casein-specific IgG level in NC/Nga mice fed on a casein diet. The percentage of CD4(+)CD25(+) cells was increased in DO11.10 mice orally given OVA, but this increase of CD4(+)CD25(+) cells were suppressed in L. lactis-fed DO11.10 mice.
authors.affiliation: Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. tohrus@nutr.med.tokushiama-u.ac.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Sakai
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hirota
authors.forename: Mariko
authors.initials: M
authors.lastname: Nakamoto
authors.forename: Emi
authors.initials: E
authors.lastname: Shuto
authors.forename: Toshio
authors.initials: T
authors.lastname: Hosaka
authors.forename: Seiya
authors.initials: S
authors.lastname: Makino
authors.forename: Shuji
authors.initials: S
authors.lastname: Ikegami
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002364:Caseins / Q000008:administration & dosage / Q000276:immunology; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects; D018928:Immunity, Mucosal; D007114:Immunization; D007136:Immunoglobulins / Q000032:analysis* / Q000096:biosynthesis; D013294:Lactococcus lactis / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology*; D019936:Probiotics / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D002364:Caseins; D016207:Cytokines; D007136:Immunoglobulins; D010047:Ovalbumin