title: Cytotoxic clerodane diterpenes from Casearia rupestris.
abstract: Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Casearupestrin A (1) exhibited the most potent activity against MDA/MB-435 (human melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug doxorubicin.
authors.affiliation: Institute of Chemistry, Nucley of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, C.P. 14801-970, Araraquara, SP, Brazil.
authors.forename: Gerardo M
authors.initials: GM
authors.lastname: Vieira-Júnior
authors.forename: Luiz A
authors.initials: LA
authors.lastname: Dutra
authors.forename: Paulo M P
authors.initials: PM
authors.lastname: Ferreira
authors.forename: Manoel O
authors.initials: MO
authors.lastname: de Moraes
authors.forename: Letícia V
authors.initials: LV
authors.lastname: Costa Lotufo
authors.forename: Cláudia do Ó
authors.initials: Cdo Ó
authors.lastname: Pessoa
authors.forename: Roseli Buzanelli
authors.initials: RB
authors.lastname: Torres
authors.forename: Nivaldo
authors.initials: N
authors.lastname: Boralle
authors.forename: Vanderlan da S
authors.initials: Vda S
authors.lastname: Bolzani
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: Cavalheiro
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D037821:Casearia / Q000737:chemistry*; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D004317:Doxorubicin