title: [Hydroxyurea induced-leg ulcer in polycythemia vera].
abstract: BACKGROUND
  Hydroxyurea (HU) is an antineoplastic drug commonly used to treat chronic myeloproliferative disorders. Dermatological side effects are frequent and usually benign. Leg ulceration following HU therapy is less common.
  
  
  OBJECTIVE
  To describe epidemioclinical and therapeutic features of leg ulcers induced by HU.
  
  
  METHODS
  A 70-year-old woman is treated with hydroxyurea for polycythemia vera. One year later; she presented with a malleolar painful ulcer, initially healed without discontinuation of the treatment, but has been recurred 2 months later, becoming multiple and bilateral. HU has been discontinued and ulcers were completely cured.
  
  
  CONCLUSIONS
  Leg ulcers induced by hydroxyurea are rare. Pathogenesis of HU-induced ulcers remains unknown and is multi factorial. Discontinuation of treatment is still the option of choice for complete recovery.
authors.affiliation: Service de Dermatologie, Hôpital Charles Nicolle de Tunis, Université Tunis El Manar, Tunis, Tunisie.
authors.forename: Aida
authors.initials: A
authors.lastname: Khaled
authors.forename: Nadia
authors.initials: N
authors.lastname: El Guellali
authors.forename: Lamia
authors.initials: L
authors.lastname: Aissaoui
authors.forename: Feriel
authors.initials: F
authors.lastname: Robbana
authors.forename: Nadia
authors.initials: N
authors.lastname: Ezzine
authors.forename: Becima
authors.initials: B
authors.lastname: Fazaa
authors.forename: Mohamed Ridha
authors.initials: MR
authors.lastname: Kamoun
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use; D007871:Leg Ulcer / Q000209:etiology*; D011087:Polycythemia Vera / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea