title: Adherence to Treatment Guidelines in Breast Cancer Care - a Retrospective Analysis of the 'Organgruppe Mamma der Arbeitsgemeinschaft Gynaekologische Onkologie'
abstract: BACKGROUND: The Organgruppe Mamma of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) performed a nationwide 3-phase analysis of the structure of care and standard of therapy given to patients with breast cancer from 2002 (4th quarter) to 2004 (4th quarter). The extent to which national and international treatment recommendations are implemented in routine clinical practice had so far not been evaluated in an interdisciplinary approach. No reliable data on the pattern of care of these patients have been published in Germany before. PATIENTS AND METHODS: The project included early breast cancer in the adjuvant and neoadjuvant setting as well as metastatic disease. We present the results of phase III of the AGO analysis, which are based on a survey conducted by the Organkommission Mamma in the 4th quarter of 2004. RESULTS: Evaluation of the data reveals that treatment based on the guidelines is now being implemented very reliably in certain sectors. This is of particular relevance to the pattern of adjuvant treatment in early breast cancer. In contrast, in metastatic breast cancer (MBC), the complexity of the interdisciplinary treatment approach is complicating this kind of straightforward analysis. CONCLUSION: The present analysis conducted by the AGO was the first attempt to analyse the treatment provided in patients presenting with MBC in a systematic fashion. The fundamental problem remains, irrespective of the stage of the tumour, that too few patients are treated in randomised clinical trials. The mission set by the AGO-Organkommission Mamma is the longitudinal observation of the therapy practices for breast cancer on the basis of the observations discussed here, which should ultimately benefit the optimisation of therapy quality in Germany.
authors.affiliation: Clinic for Gynaecology and Obstetrics, Klinikum Offenbach GmbH.
authors.forename: Christian
authors.initials: C
authors.lastname: Jackisch
authors.forename: Michael
authors.initials: M
authors.lastname: Untch
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Chatsiproios
authors.forename: Christiane
authors.initials: C
authors.lastname: Lamparter
authors.forename: Friedrich
authors.initials: F
authors.lastname: Overkamp
authors.forename: Werner
authors.initials: W
authors.lastname: Lichtenegger
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Rönsberg
authors.forename: Christoph
authors.initials: C
authors.lastname: Thomssen
authors.forename: Gunter
authors.initials: G
authors.lastname: von Minckwitz
authors.forename: Ute-Susann
authors.initials: US
authors.lastname: Albert