title: [The correlation between the expression of AQP1 and angiogenesis ability in nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To investigate the expression and correlation of Aquaporin-1 (AQP1), VEGF and MVD in nasopharyngeal tumor and non-tumor tissues.
  
  
  METHODS
  Thirty nasopharyngeal biopsy samples were collected and examined with both immunohistochemistry and real-time fluorescence quantitative PCR (RT-PCR) to detect the expression level of AQP1 and VEGF in tissues. MVD were then calculated.
  
  
  RESULTS
  Both immunohistochemistry and RT-PCR showed higher expression of AQP1 and VEGF in tumor tissues than in non-tumor tissues. The two factors were positively correlated.
  
  
  CONCLUSIONS
  In nasopharyngeal carcinoma, AQP1 may participate in angiogenesis by VEGF. Thus it may facilitate the tumor's growing and metastasis.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Southern Medical University, Guangzhou, 510515, China. hxllq@126.com
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Bao
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D051398:Aquaporin 1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D055815:Young Adult
chemical_list: C496020:AQP1 protein, human; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D051398:Aquaporin 1