title: Two new monoterpene alkaloid derivatives from the roots of Incarvillea arguta.
abstract: Two new monoterpene alkaloid derivatives, incargutosines C (1) and D (2), together with a known compound, argutine A (3) have been isolated from the roots of Incarvillea arguta Royle. The structures of 1 and 2 were established on the basis of 1D and 2D NMR spectroscopic analysis, while the absolute configurations of 1 and 2 were determined by a synthetic method. In addition, the cytotoxicity of 3 was evaluated using four tumor cell lines, A549, LOVO, 6TCEM, and MDA-MB-435 (MDA) by the MTT assay.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jian Jun
authors.initials: JJ
authors.lastname: Fu
authors.forename: Jiang Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Qi
authors.initials: Q
authors.lastname: Zeng
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Zhang
authors.forename: Hui Zi
authors.initials: HZ
authors.lastname: Jin
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D039821:Monoterpenes