title: Adult neurogenesis and the plasticity of the dentate gyrus network.
abstract: The granule cell layer (GCL) of the dentate gyrus contains neurons generated during embryonic, early postnatal and adult life. During adulthood there is a continuous production of neuronal cohorts that develop and functionally integrate in the preexisting circuits. This morphogenic process generates a stratified GCL, with the outermost layers containing dentate granule cells (DGCs) generated during perinatal life, and the innermost layers containing adult-born DGCs. In this review we analyse the functional profile of the different neuronal populations of the GCL, with an emphasis on adult-born neurons as they develop, mature and integrate in the dentate gyrus network. We focus on the contribution of adult-born neurons to activity-dependent synaptic modification in the dentate gyrus and, in turn, discuss how network activity modulates integration and survival of new neurons.
authors.affiliation: Laboratory of Neuronal Plasticity, Leloir Institute - CONICET, Buenos Aires, Argentina.
authors.forename: Lucas A
authors.initials: LA
authors.lastname: Mongiat
authors.forename: Alejandro F
authors.initials: AF
authors.lastname: Schinder
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation; D018891:Dentate Gyrus / Q000166:cytology* / Q000502:physiology*; D058953:Neural Stem Cells / Q000166:cytology / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D013569:Synapses / Q000378:metabolism