title: Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation.
abstract: A series of rabdokunmin C analogues were prepared and their inhibitory effect on NF-κB activation was assayed. One of them, 18-acetyl-12-deoxy-11,12-dehydrorabdokunmin C (16) was found to be a promising candidate for an anti-inflammatory agent.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Adachi
authors.forename: Kei
authors.initials: K
authors.lastname: Ozawa
authors.forename: Chihiro
authors.initials: C
authors.lastname: Yokomizo
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Gui
authors.forename: Yong-Ri
authors.initials: YR
authors.lastname: Jin
authors.forename: Xu-Wen
authors.initials: XW
authors.lastname: Li
authors.forename: Naohito
authors.initials: N
authors.lastname: Ohno
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeya
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D045786:Diterpenes, Kaurane / Q000138:chemical synthesis / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D004224:Diterpenes; D045786:Diterpenes, Kaurane; D016328:NF-kappa B; C002627:kaurene