title: miR-221 Is down-regulated in TMPRSS2:ERG fusion-positive prostate cancer.
abstract: Expression profiling studies using microarrays and other methods have shown that microRNAs (miRNAs) are dysregulated in a wide variety of human cancers. The up-regulation of miR-221 has been reported in carcinomas of the pancreas, breast, and papillary thyroid, as well as in glioblastoma and chronic lymphocytic leukaemia. In prostate cancer, however, down-regulation of miR-221 has been repeatedly confirmed in miRNA expression studies. Also unique to prostate cancer, and found in more than 50% of patients, is the aberrant expression of a known oncogene, the TMPRSS2:ERG fusion. To date, there has been no published study describing miRNA associations in prostate tumours that overexpress the ERG oncogene from the TMPRSS2:ERG fusion transcript. Herein we report that in a large and diverse cohort of prostate carcinoma samples, miR-221 is down-regulated in patients with tumours bearing TMPRSS2:ERG fusion transcripts, thus providing a link between miRNA and gene fusion expression.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, and Sunnybrook Research Institute, Toronto, Canada.
authors.forename: Aida
authors.initials: A
authors.lastname: Gordanpour
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Stanimirovic
authors.forename: Robert K
authors.initials: RK
authors.lastname: Nam
authors.forename: Carlos S
authors.initials: CS
authors.lastname: Moreno
authors.forename: Christopher
authors.initials: C
authors.lastname: Sherman
authors.forename: Linda
authors.initials: L
authors.lastname: Sugar
authors.forename: Arun
authors.initials: A
authors.lastname: Seth
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D050939:Gene Fusion; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015514:Oncogene Proteins, Fusion / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D035683:MicroRNAs; D015514:Oncogene Proteins, Fusion; C525709:MIR221, human; C515553:TMPRSS2-ERG fusion protein, human