title: Mitochondrial protection by resveratrol.
abstract: Mitochondrial dysfunction and oxidative stress are thought to play important roles in mammalian aging. Resveratrol is a plant-derived polyphenol that exerts diverse antiaging activities, mimicking some of the molecular and functional effects of dietary restriction. This review focuses on the molecular mechanisms underlying the mitochondrial protective effects of resveratrol, which could be exploited for the prevention or amelioration of age-related diseases in the elderly.
authors.affiliation: Reynolds Oklahoma Center on Aging, Departments of Geriatric Medicine and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, USA. zoltan-ungvari@ouhsc.edu
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Ungvari
authors.forename: William E
authors.initials: WE
authors.lastname: Sonntag
authors.forename: Rafael
authors.initials: R
authors.lastname: de Cabo
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Baur
authors.forename: Anna
authors.initials: A
authors.lastname: Csiszar
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D031204:Caloric Restriction; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000187:drug effects*; D051267:NF-E2-Related Factor 2 / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects*; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000502:physiology; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D051267:NF-E2-Related Factor 2; D013267:Stilbenes; D056564:Sirtuin 1; D000077185:Resveratrol