title: Antigen engineering in DNA immunization.
abstract: J. A. Wolff and colleagues demonstrated in 1990 (1) that naked, non-infectious DNA plasmids can be transferred into muscle cells of living mice to express the encoded protein in vivo. Further studies have shown that proteins expressed in vivo via such a "DNA inoculation" process can serve as immunogens to effectively stimulate the body's immune system to produce potentially strong, long-lasting, antigen-specific, humoral and cell-mediated immune responses (2-8).
authors.affiliation: Department of Medicine, University of Massachusetts Medical Center, Worcester, MA.
authors.forename: S
authors.initials: S
authors.lastname: Lu
authors.forename: S
authors.initials: S
authors.lastname: Manning
authors.forename: J
authors.initials: J
authors.lastname: Arthos