title: Pharmacovigilance in veterinary medicine in Chile: a pilot study.
abstract: Iragüen, D., Urcelay, S., San Martín, B. Pharmacovigilance in veterinary medicine in Chile: a pilot study. J. vet. Pharmacol. Therap.34, 108-115. In Chile, there is no present government policy to survey and analyse adverse drug reactions (ADRs) in the field of veterinary medicine. The intent of this study is to assess, for the first time, ADR frequency in treated animals. To this purpose, a 6-month period pilot study based on WHO recommendations was conducted to monitor ADRs in cats and dogs for frequently used drugs and common labelled signs. Of a total of 149 detected ADRs, 29 (6 in cats and 23 in dogs) were notified by means of ADR report forms, while the rest was identified after reviewing patient clinical records, thus evidencing strong under-reporting problems. More than 70% of ADRs were related to antimicrobials, vaccines and tranquilizers. In dogs, there was a significant effect on ADRs' presentation when acepromazine, amoxicillin, carprofen, ivermectin, sextuple vaccine (polyvalent vaccine that confers immunity against canine distemper virus, canine parvovirus, Leptospira canicola, L. icterohemmoragiae, canine adenovirus type 2 and canine parainfluenza virus) and phytomenadione (subcutaneous injection) were administered. In the case of cats, a significant influence on ADRs was detected when acepromazine, amoxicillin or vitamin K was administered. Present results suggest the need for a pharmacovigilance programme in veterinary medicine for timely ADR-presenting drug detection and drug safety improvement.
authors.affiliation: Laboratory of Veterinary Pharmacology, Department of Clinical Sciences, Faculty of Veterinary Science, Universidad de Chile, Santiago, Chile. diraguen@uchile.cl
authors.forename: D
authors.initials: D
authors.lastname: Iragüen
authors.forename: S
authors.initials: S
authors.lastname: Urcelay
authors.forename: B
authors.initials: B
authors.lastname: San Martín
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D002371:Cat Diseases / Q000139:chemically induced / Q000188:drug therapy; D002415:Cats; D002677:Chile; D004283:Dog Diseases / Q000139:chemically induced / Q000188:drug therapy; D004285:Dogs; D010865:Pilot Projects; D011358:Product Surveillance, Postmarketing; D014149:Tranquilizing Agents / Q000009:adverse effects; D014612:Vaccines / Q000009:adverse effects; D019155:Veterinary Drugs / Q000009:adverse effects*; D014730:Veterinary Medicine / Q000592:standards*
chemical_list: D000900:Anti-Bacterial Agents; D014149:Tranquilizing Agents; D014612:Vaccines; D019155:Veterinary Drugs