title: Molecular genetics of hypothalamic-pituitary-adrenal axis activity and function.
abstract: The hypothalamic-pituitary-adrenocortical (HPA) axis is a major neuroendocrine system involved in the regulation of numerous physiological processes and in adaptation to stress. A wide range of variability can be observed in all the components of the system, and the contribution of genetic factors has been shown in the central regulation of the axis, the production of glucocorticoid hormones by the adrenal cortex, their bioavailability, and the efficiency of their action at the level of receptor and postreceptor mechanisms. Numerous molecular polymorphisms have been described that contribute to physiological variation as well as to HPA axis-related pathological conditions. Although most studies focus on single gene polymorphisms, future studies should aim to integrate the different sources of variation into a systems genetic model to take into account the strong interdependence of the different components of the axis.
authors.affiliation: Université de Bordeaux, PsyNuGen, Bordeaux, France. pierre.mormede@toulouse.inra.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Mormede
authors.forename: Aline
authors.initials: A
authors.lastname: Foury
authors.forename: Pascal
authors.initials: P
authors.lastname: Barat
authors.forename: Jean-Benoit
authors.initials: JB
authors.lastname: Corcuff
authors.forename: Elena
authors.initials: E
authors.lastname: Terenina
authors.forename: Nathalie
authors.initials: N
authors.lastname: Marissal-Arvy
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Moisan
mesh_terms: D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D006801:Humans; D007030:Hypothalamo-Hypophyseal System