title: [Locoregional recurrences after conservative surgery in early breast cancer].
abstract: BACKGROUND
  Conservative surgery is considered as standard and alternative mastectomy in early stage breast cancer but number of local recurrence is higher. Aim of the study was to detect number of local recurrences after conservative surgery and to identify risk factors of local recurrence especially importance of resection margins.
  
  
  METHODS
  Local recurrences were evaluated in patients after conservative surgery in early breast cancer at department of surgery Atlas hospital in Zlin between January 2004 and December 2008. T1-2 (only one T3) breast cancers were included in study. Diagnostic biopsy, lumpectomy and quadrantectomy were performed. In all patients axillary nodes were examined. Study guidelines required microscopic distance between resection line and tumor margin 5mm. Specimen after surgery was marked with black ink and from June 2006 with six colors ink. Radiotherapy and chemotherapy in additions to character of cancer followed surgery.
  
  
  RESULTS
  Conservative surgery was performed in 330 patients. Mean age was 59 years. Follow-up was 39.6 month. Stage of the tumor: 0 19x, I 101x, IIA 163x, IIB 33x, IIIA 5, IIIB 0, IIIC 9. Lumpectomy was made 11 lx including 11 diagnostic biopsies and quadrantectomy 219x. Final conservative surgery was 331x and mastectomy 19x. Positive axillary nodes were 98x. In breast local recurrence appeared in 5 (3.6%) patients and one had regional recurrence without in breast recurrence. Distant metastases were 8x (2.4%) and ten patient died on primary disease without locoregional recurrence.
  
  
  CONCLUSIONS
  Local recurrence appeared only 5x. Clear margins after breast conserving surgery are very important factor in prevention local recurrence. We recommend keeping 5 mm resection distance.
authors.affiliation: Chirurgické Oddelení Nemocnice Atlas, Univerzita Tomáse Bati ve Zlíne.
authors.forename: J
authors.initials: J
authors.lastname: Gatek
authors.forename: J
authors.initials: J
authors.lastname: Kotoc
authors.forename: K
authors.initials: K
authors.lastname: Kotocová
authors.forename: J
authors.initials: J
authors.lastname: Katrusák
authors.forename: P
authors.initials: P
authors.lastname: Vázan
authors.forename: J
authors.initials: J
authors.lastname: Duben
authors.forename: L
authors.initials: L
authors.lastname: Hnátek
authors.forename: B
authors.initials: B
authors.lastname: Dudesek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008408:Mastectomy; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local