title: The investigation of congenital infection by Trypanosoma cruzi in an endemic area of Chile: three protocols explored in a pilot project.
abstract: Given the increasing travel of pregnant women from areas were Trypanosoma cruzi is endemic, the congenital transmission of the parasite has become a global public-health problem. In a recent pilot study, which ran in Chile from 2006 to 2010, three strategies for exploring and managing T. cruzi-infected mothers and their infected or uninfected neonates were investigated. Any protocols applied to the investigation of such mother-and-child pairs need to include the detection of infection in pregnant women, the detection of infection, if any, in the children born to the women, the appropriate treatment of the infected neonates, and the serological-parasitological follow-up of all of the neonates until their medical discharge.
authors.affiliation: Laboratorio de Parasitologia Básico-Clínico, Programa de Biologia Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: I
authors.initials: I
authors.lastname: Zulantay
authors.forename: G
authors.initials: G
authors.lastname: Corral
authors.forename: M C
authors.initials: MC
authors.lastname: Guzman
authors.forename: F
authors.initials: F
authors.lastname: Aldunate
authors.forename: W
authors.initials: W
authors.lastname: Guerra
authors.forename: I
authors.initials: I
authors.lastname: Cruz
authors.forename: A
authors.initials: A
authors.lastname: Araya
authors.forename: V
authors.initials: V
authors.lastname: Tapia
authors.forename: F
authors.initials: F
authors.lastname: Marquez
authors.forename: C
authors.initials: C
authors.lastname: Muñoz
authors.forename: W
authors.initials: W
authors.lastname: Apt
mesh_terms: D014355:Chagas Disease / Q000151:congenital* / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission; D002677:Chile / Q000453:epidemiology; D002985:Clinical Protocols; D004334:Drug Administration Schedule; D019353:Endemic Diseases; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008134:Long-Term Care / Q000379:methods; D018743:Perinatal Care / Q000379:methods; D010865:Pilot Projects; D011181:Postnatal Care / Q000379:methods; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000175:diagnosis; D011297:Prenatal Exposure Delayed Effects; D012698:Serologic Tests / Q000379:methods; D014344:Trypanocidal Agents / Q000008:administration & dosage
chemical_list: D014344:Trypanocidal Agents