title: History, technical and regulatory aspects of exhaled nitric oxide.
abstract: The history of nitric oxide (NO) in exhaled breath as a marker of inflammation is summarized, followed by measurement aspects of exhaled NO including NO excretion models of NO in the airway, the estimation of flow-independent NO exchange parameters and issues with the standardization of these methods. Regulatory considerations in the US are also presented. A brief summary of the state of the art for clinical application of exhaled NO is also included.
authors.affiliation: Drexel University, Philadelphia, PA, USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Silkoff