title: Cellular basis of Alzheimer's disease.
abstract: Alzheimer's disease (AD) is the most common form of neurodegenerative disease. A characteristic feature of the disease is the presence of amyloid-β (Aβ) which either in its soluble oligomeric form or in the plaque-associated form is causally linked to neurodegeneration. Aβ peptide is liberated from the membrane-spanning -amyloid precursor protein by sequential proteolytic processing employing β- and γ-secretases. All these proteins involved in the production of Aβ peptide are membrane associated and hence, membrane trafficking and cellular compartmentalization play important roles. In this review, we summarize the key cellular events that lead to the progression of AD.
authors.affiliation: Systems and Cell Biology of Neurodegeneration, Psychiatry Research, University of Zürich, 8008 Zurich, Switzerland.
authors.forename: Jitin
authors.initials: J
authors.lastname: Bali
authors.forename: Saoussen Ben
authors.initials: SB
authors.lastname: Halima
authors.forename: Boas
authors.initials: B
authors.lastname: Felmy
authors.forename: Zoe
authors.initials: Z
authors.lastname: Goodger
authors.forename: Sebastian
authors.initials: S
authors.lastname: Zurbriggen
authors.forename: Lawrence
authors.initials: L
authors.lastname: Rajendran