title: Oocyte developmental competence and embryo development: impact of lifestyle and environmental risk factors.
abstract: Oocyte development is the end result of a sophisticated biological process that is hormonally regulated and produced by highly specialized cellular lines that differentiate in early embryo/fetal development. Embryo development is initially regulated by maternal transcripts until replaced by embryonic genomic expression. Then, an assortment of hormones and local environmental factors in various concentrations along the reproductive tract (e.g. fallopian tube, endometrial lining) provide the protection, nutrients and means of communication for the embryo to implant and develop. Both oocytes and embryos are susceptible to environmental, occupational and lifestyle exposures that can exert direct toxic effects and disrupt hormones. While some exposures may produce reversible changes, others, especially those damaging germinal cells in utero or during prepuberty, may result in permanent sequelae that continue in future generations. This article reviews the main factors that affect female fertility and their possible influence on human reproduction. Some lifestyles, xeno-oestrogens and heavy metals are already known to compromise female reproductive function. Nonetheless, many questions remain and little is known about the effect of many other factors on female fertility.
authors.affiliation: Fertility Clinic and IVF Department, AMRI Medical Centre, Kolkata, India.
authors.forename: Alex C
authors.initials: AC
authors.lastname: Varghese
authors.affiliation: Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Kim D
authors.initials: KD
authors.lastname: Ly
authors.affiliation: Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Cresandra
authors.initials: C
authors.lastname: Corbin
authors.affiliation: Public Health and Epidemiology Research Group, School of Medicine, University of Murcia, Murcia, Spain.
authors.forename: Jaime
authors.initials: J
authors.lastname: Mendiola
authors.affiliation: Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Ashok
authors.initials: A
authors.lastname: Agarwal
mesh_terms: D000818:Animals; D033041:Embryo Research / Q000266:history*; D006801:Humans; D019836:Preimplantation Diagnosis / Q000266:history*