title: Maintenance of remission with cyclosporine in paediatric patients with Kimura's disease - two case reports.
abstract: Here we report two paediatric cases of Kimura's disease, which is a rare, chronic inflammatory disorder with undetermined aetiology. The first patient was a 17-year-old boy presenting with a swelling behind his right ear and a nephrotic syndrome. The second patient was a 9-year-old boy presenting with a left-sided preauricular swelling. Both displayed peripheral blood eosinophilia, raised levels of serum IgE and typical histological findings. Initial response to prednisolone was excellent but both relapsed as medication was tapered or discontinued. Adding cyclosporine to the regimen resulted in prolonged remission in both patients.
  
  
  CONCLUSIONS
  We support the use of cyclosporine for maintaining remission in paediatric patients with Kimura's disease.
authors.affiliation: Department of Hematology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Sandra
authors.initials: S
authors.lastname: Soeria-Atmadja
authors.forename: Trausti
authors.initials: T
authors.lastname: Oskarsson
authors.forename: Gianni
authors.initials: G
authors.lastname: Celci
authors.forename: Birgitta
authors.initials: B
authors.lastname: Sander
authors.forename: Ulla
authors.initials: U
authors.lastname: Berg
authors.forename: Britt
authors.initials: B
authors.lastname: Gustafsson
mesh_terms: D000293:Adolescent; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000175:diagnosis / Q000188:drug therapy*; D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D060046:Maintenance Chemotherapy; D008297:Male
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine