title: [Sugar of substitute stevioside in chewing gum: comparative double blind controllable study].
abstract: In double blind controllable study on 126 volunteers - students of medical academy - influence on рН the mixed saliva of 5 kinds of chewing gums with the different contents of substitute of sugar as xylitol and sorbitol, and also the chewing sweets R.O.C.S., two kinds of chewing gums containing a basis with substitute of sugar stevioside (1.25 and 2.5%) and placebo (a basis without additives) were investigated. Products chewed within 10 minutes. In one of groups surveyed such chewing was preceded with rinsing a mouth by a test solution of saccharose. рН determined within 30 minutes. At chewing gums with substitute of sugar displacement рН the mixed saliva in the alkaline side was revealed a different degree. Thus gums with stevioside did not concede and even surpassed in this action of chewing gums with other substitutes of sugar. In comparison with placebo chewing gums and sweets restored acid-alkaline balance of oral cavities faster. Hence, use of stevioside in structure of chewing gum allows at preservation of its positive actions in oral cavity essentially to reduce concentration substitute of sugar and, hence, its collateral action by an organism.
authors.forename: V A
authors.initials: VA
authors.lastname: Rumiantsev
authors.forename: V V
authors.initials: VV
authors.lastname: Beliaev
authors.forename: V A
authors.initials: VA
authors.lastname: Zubtsov
authors.forename: L K
authors.initials: LK
authors.lastname: Esaian
authors.forename: I V
authors.initials: IV
authors.lastname: Namestnikova
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000293:Adolescent; D000328:Adult; D002638:Chewing Gum; D045786:Diterpenes, Kaurane / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005960:Glucosides / Q000008:administration & dosage*; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008297:Male; D012463:Saliva / Q000737:chemistry / Q000187:drug effects*; D013549:Sweetening Agents / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D002638:Chewing Gum; D045786:Diterpenes, Kaurane; D005960:Glucosides; D013549:Sweetening Agents; C012043:stevioside