title: A SERS DNAzyme biosensor for lead ion detection.
abstract: SERS biosensor for sensitive and selective detection of lead ions (Pb(2+)) based on DNAzyme was developed by taking advantage of the specific catalytic reaction of DNAzyme upon binding to Pb(2+) ions. Detection was accomplished by SERS nanoprobe labeled with DNA and Raman reporters for signal amplification.
authors.affiliation: Bindley Bioscience Center and Birck Nanotechnology Center, Purdue University 225 S, University Street, 215 ABE Building, West Lafayette, IN 47907, USA.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Wang
authors.forename: Joseph
authors.initials: J
authors.lastname: Irudayaraj
mesh_terms: D001483:Base Sequence; D015374:Biosensing Techniques / Q000379:methods*; D021881:DNA, Catalytic / Q000235:genetics / Q000378:metabolism*; D006046:Gold / Q000737:chemistry; D007854:Lead / Q000032:analysis* / Q000737:chemistry* / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D013499:Surface Properties
chemical_list: D021881:DNA, Catalytic; D007854:Lead; D006046:Gold