title: Urticaria due to antihistamines.
abstract: H1-antihistamines are probably the most frequently used drugs in allergic diseases, with widely established efficacy, tolerance, and safety. We report a patient with urticaria due to ingestion of ebastine and fexofenadine. Skin prick tests, patch tests, and basophil activation tests with the implicated drugs and antihistamines from other families were negative. The oral challenges with the implicated antihistamines and other antihistamines tested were positive, but the patient tolerated an oral challenge with cetirizine. We present a patient with urticaria induced by different antihistamines in whom the diagnosis was established by oral challenge. The mechanism of sensitization remains unclear.
authors.affiliation: Allergology Department, Hospital Central de la Cruz Roja, Madrid, Spain. lsanchezmorillas@hotmail.com
authors.forename: L
authors.initials: L
authors.lastname: Sánchez Morillas
authors.forename: P
authors.initials: P
authors.lastname: Rojas Pérez-Ezquerra
authors.forename: M
authors.initials: M
authors.lastname: Reaño Martos
authors.forename: M L
authors.initials: ML
authors.lastname: Sanz
authors.forename: J J
authors.initials: JJ
authors.lastname: Laguna Martínez
mesh_terms: D000284:Administration, Oral; D002090:Butyrophenones / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D039563:Histamine H1 Antagonists, Non-Sedating / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects*; D016593:Terfenadine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D014581:Urticaria / Q000175:diagnosis / Q000209:etiology*
chemical_list: D002090:Butyrophenones; D006634:Histamine H1 Antagonists; D039563:Histamine H1 Antagonists, Non-Sedating; D010880:Piperidines; D016593:Terfenadine; C093230:fexofenadine; C058249:ebastine