title: Isolation of a novel Aggregatibacter actinomycetemcomitans serotype b bacteriophage capable of lysing bacteria within a biofilm.
abstract: A bacteriophage specific for Aggregatibacter actinomycetemcomitans serotype b, able to kill the bacterium within a biofilm, was isolated. Random mutagenesis of this phage rendered a bacteriophage able to kill 99% of the bacteria within a biofilm. This is the first report of a biocontrol experiment against A. actinomycetemcomitans.
authors.affiliation: Laboratorio de Microbiología y Biotecnología Oral, Universidad Andres Bello, Echaurren 237, Santiago, Chile.
authors.forename: Mario
authors.initials: M
authors.lastname: Castillo-Ruiz
authors.forename: Enrique D
authors.initials: ED
authors.lastname: Vinés
authors.forename: Camilo
authors.initials: C
authors.lastname: Montt
authors.forename: Jorge
authors.initials: J
authors.lastname: Fernández
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Delgado
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Hormazábal
authors.forename: Mauricio
authors.initials: M
authors.lastname: Bittner
mesh_terms: D001433:Bacteriolysis; D001435:Bacteriophages / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification*; D018441:Biofilms / Q000254:growth & development*; D016296:Mutagenesis; D009153:Mutagens / Q000378:metabolism; D015661:Pasteurellaceae / Q000254:growth & development* / Q000821:virology*; D010572:Pest Control, Biological / Q000379:methods
chemical_list: D009153:Mutagens