title: Severe spontaneous acute tumor lysis syndrome and hypoglycemia in patient with germ cell tumor.
abstract: Tumor lysis syndrome has been observed in patients with bulky, treatment-sensitive tumors, in particular hematological malignancies, especially after medical treatment (chemotherapy, corticosteroids, radiation, hormonal agents, and biological response modifiers). Tumor lysis syndrome has been observed also in solid malignancies and it very rarely occurs spontaneously. Tumor lysis syndrome-associated metabolic abnormalities include hyperuricemia, hyperphosphatemia, hyperkalemia, hypocalcemia and uremia. Severe hypoglycemia is another rare metabolic disorder, uncommonly associated with solid malignancies. The case described here is peculiar for the abrupt onset of these two rare conditions in a patient with a metastatic germ cell tumor.
authors.affiliation: Unit of Internal Medicine, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy. v.dalessandro@operapadrepio.it
authors.forename: Vito
authors.initials: V
authors.lastname: D'Alessandro
authors.forename: Antonio
authors.initials: A
authors.lastname: Greco
authors.forename: Celeste
authors.initials: C
authors.lastname: Clemente
authors.forename: Marco
authors.initials: M
authors.lastname: Sperandeo
authors.forename: Angelo
authors.initials: A
authors.lastname: De Cata
authors.forename: Concetta
authors.initials: C
authors.lastname: Di Micco
authors.forename: Evaristo
authors.initials: E
authors.lastname: Maiello
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Vendemiale
mesh_terms: D000208:Acute Disease; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002822:Choriocarcinoma / Q000097:blood / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000209:etiology*; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008113:Liver Neoplasms / Q000150:complications / Q000556:secondary; D008175:Lung Neoplasms / Q000150:complications / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D010928:Placental Lactogen / Q000032:analysis; D012720:Severity of Illness Index; D013736:Testicular Neoplasms / Q000097:blood / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D015275:Tumor Lysis Syndrome / Q000097:blood / Q000209:etiology*; D014746:Vimentin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D014746:Vimentin; D000509:alpha-Fetoproteins; D007633:Keratins; D010928:Placental Lactogen