title: Mild addition of nucleophiles to pyridine-N-oxides.
abstract: A general and facile one-pot procedure for the synthesis of 2-substituted pyridines from the corresponding pyridine-N-oxides and nucleophiles is presented as a mild alternative to S(N)Ar chemistry. A variety of nucleophiles and heterocyclic-N-oxides participate effectively in this transformation, which uses the phosphonium salt, PyBroP, as a means of substrate activation.
authors.affiliation: CVMED Medicinal Chemistry, Pfizer Inc., Eastern Point Road, Groton, Connecticut, 06340, United States. allyn.t.londregan@pfizer.com
authors.forename: Allyn T
authors.initials: AT
authors.lastname: Londregan
authors.forename: Sandra
authors.initials: S
authors.lastname: Jennings
authors.forename: Liuqing
authors.initials: L
authors.lastname: Wei
mesh_terms: D000586:Amination; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*
chemical_list: D011725:Pyridines; C013229:pyridine N-oxide