title: Hodgkin disease and the role of the immune system.
abstract: Hodgkin disease (HD) is a malignancy of primarily B lymphocytes that has the unique ability to cause immunodeficiency, as well as provide immune evasion mechanisms to avoid self-destruction. In this review, the authors discuss Hodgkin disease, its association with Epstein-Barr virus (EBV), the immune deficiency caused by HD, and tumor immune evasion mechanisms. Specifically, the authors closely evaluate the roles of regulatory T cells in HD, cytotoxic T cells, cytokine and chemokine secretion, down-regulation of Fas ligand, and indoleamine 2,3-dioxygenase (IDO) secretion.
authors.affiliation: Baylor College of Medicine, Texas Children's Hospital, TX, USA.
authors.forename: Alana A
authors.initials: AA
authors.lastname: Kennedy-Nasser
authors.forename: Patrick
authors.initials: P
authors.lastname: Hanley
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Bollard
mesh_terms: D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000502:physiology*