title: DHHC palmitoyl transferases: substrate interactions and (patho)physiology.
abstract: S-palmitoylation is a reversible post-translational modification that occurs on diverse cellular proteins. Palmitoylation can affect proteins in many different ways, including regulating membrane attachment, intracellular trafficking, and membrane micro-localisation. Intracellular palmitoylation reactions are mediated by a family of recently identified aspartate-histidine-histidine-cysteine (DHHC) palmitoyl transferases. More than 20 DHHC proteins are encoded by mammalian genomes, and there is now a major effort to identify DHHC-substrate pairings and to determine how interaction specificity is encoded. Recent studies have highlighted how DHHC proteins regulate cell function and influence physiology and pathophysiology.
authors.affiliation: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Greaves
authors.forename: Luke H
authors.initials: LH
authors.lastname: Chamberlain
mesh_terms: D000217:Acyltransferases / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D019308:Palmitic Acid / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D008565:Membrane Proteins; D019308:Palmitic Acid; D000217:Acyltransferases; C504825:ZDHHC9 protein, human