title: [Experimental rationale for carcinogenic risk of asbestos cement industry and its products].
abstract: During intraperitoneal administration of dispersiveness-comparable chrysotile or asbestos cement fibers to rats (20 mg thrice), mesotheliomas were found in 45.1 and 7.7% of cases respectively. Asbestos cement dust induced tumors in 2.5% of cases, which is of biological importance. Cement or freeze asbestos destruction cement dust failed to cause tumors. The latter were not detected in a control group receiving physiological saline. Asbestos cement fibers and fascicles are covered by a cement matrix. Fiber amorphization gradually occurs. In lung tissue, there may be destruction of the cement coat of fascicles and release of native chrysotile fibers that are carcinogenic.
authors.forename: D N
authors.initials: DN
authors.lastname: Pylev
authors.forename: O V
authors.initials: OV
authors.lastname: Smirnova
authors.forename: L A
authors.initials: LA
authors.lastname: Vasil'eva
authors.forename: S A
authors.initials: SA
authors.lastname: Khrustalev
authors.forename: A I
authors.initials: AI
authors.lastname: Vezentsev
authors.forename: E A
authors.initials: EA
authors.lastname: Gudkova
authors.forename: L N
authors.initials: LN
authors.lastname: Naumova
mesh_terms: D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D003252:Construction Materials / Q000009:adverse effects*; D004195:Disease Models, Animal; D004391:Dust; D005260:Female; D007221:Industry; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors
chemical_list: D002273:Carcinogens; D004391:Dust; D001194:Asbestos