title: Base-mediated intermolecular sp2 C-H bond arylation via benzyne intermediates.
abstract: A transition-metal-free method for arylation of heterocycle and arene carbon-hydrogen bonds by aryl chlorides and fluorides has been developed. The reactions proceed via aryne intermediates and are highly regioselective with respect to the C-H bond coupling component.
authors.affiliation: Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.
authors.forename: Thanh
authors.initials: T
authors.lastname: Truong
authors.forename: Olafs
authors.initials: O
authors.lastname: Daugulis
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D047250:Calixarenes / Q000138:chemical synthesis / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D006860:Hydrogen Bonding; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001555:Benzene Derivatives; D006571:Heterocyclic Compounds; C524146:benzyne; D047250:Calixarenes