title: Basal insulin requirement is ~30% of the total daily insulin dose in type 1 diabetic patients who use the insulin pump.
abstract: OBJECTIVE
  To investigate the basal insulin requirement in total daily insulin dose in Japanese type 1 diabetic patients who use the insulin pump.
  
  
  METHODS
  The basal insulin requirement in 35 type 1 diabetic patients without detectable C-peptide using the insulin pump (Paradigm 712) was investigated during 2-3 weeks of hospitalization. The patients were served diabetic diets of 25-30 kcal/kg ideal body weight. Each meal omission was done to confirm stable blood glucose levels within 30 mg/dL variance until the next meal. Target blood glucose level was set at 100 mg/dL before each meal and 150 mg/dL at 2 h after each meal.
  
  
  RESULTS
  Total daily insulin dose was 31.6 ± 8.5 units, and total basal insulin requirement was 8.7 ± 2.9 units, which was 27.7 ± 6.9% of the total daily dose.
  
  
  CONCLUSIONS
  Basal insulin requirement is ~30% of the total daily dose in Japanese type 1 diabetic patients who use the insulin pump.
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan. kurodaakio@gmail.com
authors.forename: Akio
authors.initials: A
authors.lastname: Kuroda
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Yasuda
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Miyashita
authors.forename: Noritaka
authors.initials: N
authors.lastname: Fujiki
authors.forename: Keiko
authors.initials: K
authors.lastname: Fujisawa
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Takahara
authors.forename: Fumie
authors.initials: F
authors.lastname: Sakamoto
authors.forename: Taka-Aki
authors.initials: TA
authors.lastname: Matsuoka
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects; D002096:C-Peptide / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D007328:Insulin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D007332:Insulin Infusion Systems; D049528:Insulin, Long-Acting; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D049528:Insulin, Long-Acting