title: Clinical characteristics of the idiopathic perforation of the colon.
abstract: OBJECTIVE
  Idiopathic perforation of the colon (IPC) is an extremely rare disease, the pathogenesis of which remains poorly understood. We investigate the clinical characteristics of IPC to help improve the diagnosis and treatment of this rare condition.
  
  
  METHODS
  We performed a retrospective evaluation of 16 IPC cases diagnosed from 1999 to 2009 which included clinical findings, laboratory data, treatment procedure, and outcome.
  
  
  RESULTS
  The most common site of colon perforation was the sigmoid colon (56.3%) followed by the transverse colon (25%). The median age of the IPC patient group was 72.5 years (range: 50 to 86 y) and the mortality rate for the IPC patient group was 18.8%. Eleven patients (68.8%) had a history of chronic constipation. Creatine phosphokinase (CPK) levels were significantly higher in the survivor group than the deceased group (182 U/L vs. 50 U/L; P=0.024), and CPK levels were higher in patients with constipation than in those without constipation (187 U/L vs. 46 U/L; P=0.024). Computed tomography images showed either free air or a dirty mass that indicated extraluminal feces in all cases. The median size of a perforation was 2.0 cm (range: 0.5 to 8.0 cm). Fourteen patients had resection of the perforation segment and colostomy and 2 of these patients had resection without diverting colostomy.
  
  
  CONCLUSIONS
  IPC most commonly occurs in the sigmoid colon of elderly people who have chronic constipation. Although chronic constipation is correlated with high CPK levels, other factors, such as poor nutrition status or a delay in treatment, may be associated with an increased mortality rate in IPC patients.
authors.affiliation: Departments of Surgery, Kochi Medical School, Hata-Kenmin Hospital, Japan. tsutomun@kochi-u.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Namikawa
authors.forename: Shinzo
authors.initials: S
authors.lastname: Ozaki
authors.forename: Takehiro
authors.initials: T
authors.lastname: Okabayashi
authors.forename: Ken
authors.initials: K
authors.lastname: Dabanaka
authors.forename: Ken
authors.initials: K
authors.lastname: Okamoto
authors.forename: Toshiki
authors.initials: T
authors.lastname: Mimura
authors.forename: Michiya
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hanazaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D003106:Colon / Q000293:injuries*; D003125:Colostomy / Q000379:methods; D003248:Constipation / Q000209:etiology*; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003402:Creatine Kinase