title: Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: prevention by HDLs.
abstract: Oxidized LDLs (oxLDLs) induce various cellular dysfunctions potentially implicated in the pathogenesis of atherosclerosis. For instance, toxic concentrations of oxLDLs trigger ER stress, autophagy and apoptosis. High-density lipoproteins (HDLs) counteract several adverse biological effects triggered by oxLDLs. Our recent study reveals that HDLs inhibit the activation of ER stress and of autophagy induced by oxLDLs.
authors.affiliation: INSERM U-1048/I2MC, University Paul Sabatier, Toulouse, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Muller
authors.forename: Robert
authors.initials: R
authors.lastname: Salvayre
authors.forename: Anne
authors.initials: A
authors.lastname: Nègre-Salvayre
authors.forename: Cécile
authors.initials: C
authors.lastname: Vindis
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects*; D004336:Drug Antagonism; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects*; D006801:Humans; D008075:Lipoproteins, HDL / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000009:adverse effects* / Q000494:pharmacology; D008954:Models, Biological; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein