title: Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?
abstract: Human DDX3 is a DEAD (Asp-Glu-Ala-Asp)-box RNA helicase that appears to be a prime target for viral manipulation. While two viruses that manifest major global health threats, HIV and HCV (hepatitis C virus), utilize DDX3 for their replication, other viruses inhibit DDX3's newly identified function in innate antiviral signalling. This review discusses the role of DDX3 in antiviral immunity and its inhibition or exploitation by different viruses.
authors.affiliation: Host-Pathogen Interaction Laboratory, Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland. Martina.Schroeder@nuim.ie
authors.forename: Martina
authors.initials: M
authors.lastname: Schröder
mesh_terms: D000818:Animals; D053487:DEAD-box RNA Helicases / Q000378:metabolism / Q000502:physiology*; D004261:DNA Replication / Q000235:genetics / Q000502:physiology; D015536:Down-Regulation / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D018406:Virus Physiological Phenomena / Q000235:genetics; D014779:Virus Replication / Q000235:genetics / Q000502:physiology; D014780:Viruses / Q000235:genetics / Q000254:growth & development / Q000276:immunology / Q000378:metabolism
chemical_list: C119332:DDX3X protein, human; D053487:DEAD-box RNA Helicases