title: Crossing borders: linking environmental and genetic developmental factors.
abstract: Besides the impact of direct environmental factors, the occurrence of non-communicable adult disease is determined by non-genetic and genetic developmental factors. The broad developmental categories, developmental programing and genetic variation are often viewed as being independent of each other. The object of this review, focusing on hypertension and hypercholesterolemia, is to identify interaction between genetic and non-genetic developmental factors influencing risk factors that can contribute to the occurrence of non-communicable adult disease.
authors.affiliation: Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands. j.a.joles@umcutrecht.nl
authors.forename: Jaap A
authors.initials: JA
authors.lastname: Joles
mesh_terms: D004198:Disease Susceptibility / Q000209:etiology*; D004777:Environment; D014644:Genetic Variation; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D012307:Risk Factors