title: Using chemotherapeutic drugs to trigger hematopoietic stem cell activation and determine hematological toxicity.
abstract: Hematopoietic stem cells (HSCs) replenish blood cells throughout the lifetime of an animal. Maintaining the HSC pool is of paramount importance to the survival of the organism. Thus, when treating a patient or an animal with chemotherapeutic agents, all care must be taken to ensure that the HSC pool is minimally damaged while simultaneously eradicating the target population. Discussed here is a method to assess the potency of chemotherapeutic drugs on the hematopoietic system, their ability to activate the HSC compartment, and the damage done to the HSC pool.
authors.affiliation: Neural Stem Cell Institute, Rensselaer, New York, USA.
authors.forename: Nathan
authors.initials: N
authors.lastname: Boles
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D002469:Cell Separation / Q000379:methods; D004358:Drug Therapy; D005434:Flow Cytometry / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers