title: [Serial FDG-PET evaluation of a patchy pattern of hematopoiesis at diagnosis in aplastic anemia].
abstract: We investigated the hematopoietic status of aplastic anemia with FDG-PET before and after immunosuppressive therapy. FDG-PET showed a patchy uptake pattern before treatment, indicating residual compensatory hypercellular marrow. Three years after successful treatment with ATG plus CsA, the heterogeneity of bone marrow uptake persisted, suggesting that expanded reconstitution of hematopoiesis may require a long time even after the achievement of hematological remission.
authors.affiliation: Division of Hematology, Kitano Hospital, Tazuke Kofukai Medical Research Institute.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Hirata
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Arai
authors.forename: Shojiro
authors.initials: S
authors.lastname: Inano
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Yoshinaga
authors.forename: Wataru
authors.initials: W
authors.lastname: Maruyama
authors.forename: Akiko
authors.initials: A
authors.lastname: Fukunaga
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Arima
mesh_terms: D000741:Anemia, Aplastic / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology*; D001323:Autoantibodies / Q000008:administration & dosage; D016572:Cyclosporine / Q000008:administration & dosage; D019788:Fluorodeoxyglucose F18; D006410:Hematopoiesis; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D001323:Autoantibodies; D007166:Immunosuppressive Agents; D019275:Radiopharmaceuticals; C006606:anti-thyroglobulin; D019788:Fluorodeoxyglucose F18; D016572:Cyclosporine