title: Antinociceptive and anti-inflammatory activities of Phlomis umbrosa Turcz extract.
abstract: Phlomis umbrosa Turcz has been used as the traditional medicine for thousands of years in China. In this paper, the acetic acid-induced writhing test, the hot plate test, the carrageenan-induced paw edema test, the xylene-induced ear swelling test, and the acetic acid-induced Evans blue leakage and leukocyte infiltration test were used to investigate the antinociceptive and anti-inflammatory activities of the aqueous extract of this plant (25, 50 and 100mg/kg i.p.). Good dose-dependent effects were obtained in most of these tests, except in the hot plate test and the acetic acid-induced Evans blue leakage test. TLC and HPLC analyses showed iridoid glucosides were the main compositions of this extract. These findings suggested that the aqueous extract of P. umbrosa has significant antinociceptive and anti-inflammatory activities.
authors.affiliation: Engineering & Technology Center of Traditional Chinese Veterinary Medicine of Gansu. Research Center of Clinical Veterinary Medicine of CAAS. Lanzhou Institute of Animal and Veterinary Pharmaceutics Sciences, Chinese Academy of Agricultural Science, Lanzhou 730050, PR China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Shang
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wang
authors.forename: Maoxing
authors.initials: M
authors.lastname: Li
authors.forename: Xiaolou
authors.initials: X
authors.lastname: Miao
authors.forename: Hu
authors.initials: H
authors.lastname: Pan
authors.forename: Yaoguang
authors.initials: Y
authors.lastname: Yang
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000700:Analgesics / Q000032:analysis*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D031345:Phlomis / Q000737:chemistry*; D008517:Phytotherapy
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal