title: Surgical wound complications after heart transplantation.
abstract: Surgical wound complications are more frequent in patients undergoing heart transplantation than in other heart surgery patients. This is probably attributed to the presence of additional risk factors in these patients, such as immunosuppression, mechanical support through assist devices and generally poor health. Analyses of wound infections in heart transplantation are based on smaller patient population than those for general heart surgery, and the reported incidences vary largely. The identification of specific risk factors in heart transplant recipients to date is mainly based on retrospective case-control studies in small patient cohorts, the results are controversial, and the comparability of data is limited because of the lack of application of consistent definitions. The impact of immunosuppression and especially immunosuppression with mammalian target of rapamycin (mTOR) inhibitors on the development of surgical wound complications has been widely discussed following reports of increased occurrence with sirolimus. However, nonheart-transplant specific risk factors should also be considered to develop risk profiles and treatment algorithms for individual patients. Data on surgical wound complications in general heart surgery patients and in heart transplant recipients are compared, the impact of modern immunosuppression reviewed, and areas for further investigation discussed.
authors.affiliation: Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria. andreas.zuckermann@meduniwien.ac.at
authors.forename: Andreas
authors.initials: A
authors.lastname: Zuckermann
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Barten
mesh_terms: D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D003646:Debridement; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008480:Mediastinitis / Q000209:etiology; D009765:Obesity / Q000150:complications; D010019:Osteomyelitis / Q000209:etiology; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000209:etiology* / Q000628:therapy; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D014945:Wound Healing / Q000187:drug effects
chemical_list: D007166:Immunosuppressive Agents; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases