title: Effect of brown seaweed lipids on fatty acid composition and lipid hydroperoxide levels of mouse liver.
abstract: Brown seaweed lipids from Undaria pinnatifida (Wakame), Sargassum horneri (Akamoku), and Cystoseira hakodatensis (Uganomoku) contained several bioactive compounds, namely, fucoxanthin, polyphenols, and omega-3 polyunsaturated fatty acids (PUFA). Fucoxanthin and polyphenol contents of Akamoku and Uganomoku lipids were higher than those of Wakame lipids, while Wakame lipids showed higher total omega-3 PUFA content than Akamoku and Uganomoku lipids. The levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in liver lipids of KK-A(y) mouse significantly increased by Akamoku and Uganomoku lipid feeding as compared with the control, but not by Wakame lipid feeding. Fucoxanthin has been reported to accelerate the bioconversion of omega-3 PUFA and omega-6 PUFA to DHA and AA, respectively. The higher hepatic DHA and AA level of mice fed Akamoku and Uganomoku lipids would be attributed to the higher content of fucoxanthin of Akamoku and Uganomoku lipids. The lipid hydroperoxide levels of the liver of mice fed brown seaweed lipids were significantly lower than those of control mice, even though total PUFA content was higher in the liver of mice fed brown seaweed lipids. This would be, at least in part, due to the antioxidant activity of fucoxanthin metabolites in the liver.
authors.affiliation: Laboratory of Biofunctional Material Chemistry, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Japan. airanthi@fish.hokudai.ac.jp
authors.forename: M K Widjaja-Adhi
authors.initials: MK
authors.lastname: Airanthi
authors.forename: Naoya
authors.initials: N
authors.lastname: Sasaki
authors.forename: Sayaka
authors.initials: S
authors.lastname: Iwasaki
authors.forename: Nobuko
authors.initials: N
authors.lastname: Baba
authors.forename: Masayuki
authors.initials: M
authors.lastname: Abe
authors.forename: Masashi
authors.initials: M
authors.lastname: Hosokawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Miyashita
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005227:Fatty Acids / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008055:Lipids / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D051379:Mice; D012624:Seaweed / Q000737:chemistry*
chemical_list: D005227:Fatty Acids; D008054:Lipid Peroxides; D008055:Lipids