title: [Insulin-resistance and cardiovascular risk].
abstract: Insulin resistance is associated with a cluster of metabolic and hemodynamic abnormalities that lead to increased cardiovascular morbidity and mortality. In this review the main pathophysiological mechanisms and metabolic consequences of insulin resistance are summarized. The correlation between insulin resistance and cardiovascular disease and the practical utility of the concept of metabolic syndrome as a diagnostic tool are also discussed.
authors.affiliation: Dipartimento di Medicina Interna e Scienze Biomediche, Università degli Studi, Parma. alessandra.deicas@unipr.it
authors.forename: Alessandra
authors.initials: A
authors.lastname: Dei Cas
authors.forename: Valentina
authors.initials: V
authors.lastname: Spigoni
authors.forename: Marco
authors.initials: M
authors.lastname: Metra
authors.forename: Livio
authors.initials: L
authors.lastname: Dei Cas
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism / Q000401:mortality; D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D066298:In Vitro Techniques; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D008137:Longitudinal Studies; D008297:Male; D015201:Meta-Analysis as Topic; D024821:Metabolic Syndrome; D009765:Obesity / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013997:Time Factors