title: Clinical review: DHEA replacement for postmenopausal women.
abstract: BACKGROUND
  It has been proposed that because dehydroepiandrosterone (DHEA) and its sulfate, DHEAS, are important precursors for estrogen and androgen production, treatment with DHEA is a physiologically based strategy for the alleviation of hormone deficiency symptoms in postmenopausal women. We have summarized the physiology of DHEA in women and reviewed the findings from randomized controlled trials (RCT) of the effects of DHEA therapy in postmenopausal women with normal adrenal function.
  
  
  METHODS
  We reviewed the medical literature for key papers investigating DHEA physiology and RCT of the use of DHEA in postmenopausal women through November 2010. The focus was on sexual function, well-being, metabolic parameters, and cognition as study endpoints.
  
  
  RESULTS
  Although cross-sectional studies have indicated a link between low DHEA levels and impaired sexual function, well-being, and cognitive performance in postmenopausal women, placebo-controlled RCT do not show benefits of oral DHEA for any of these outcomes or favorable effects on lipids and carbohydrate metabolism.
  
  
  CONCLUSIONS
  Taken together, findings from this review of the published literature of studies do not support the use of DHEA in postmenopausal women at this time.
authors.affiliation: Women's Health Research Program, Department of Epidemiology and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, Victoria 3004, Australia. susan.davis@monash.edu
authors.forename: Susan R
authors.initials: SR
authors.lastname: Davis
authors.forename: Mary
authors.initials: M
authors.lastname: Panjari
authors.forename: Frank Z
authors.initials: FZ
authors.lastname: Stanczyk
mesh_terms: D003071:Cognition / Q000187:drug effects; D003687:Dehydroepiandrosterone / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D017698:Postmenopause; D016032:Randomized Controlled Trials as Topic; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy
chemical_list: D003687:Dehydroepiandrosterone