title: [A case of interstitial pneumonia during gemcitabine and cisplatin chemotherapy for locally advanced bladder cancer].
abstract: A 76-year-old woman received chemotherapy with gemcitabine and cisplatin (GC therapy) for local advanced bladder cancer. She suffered from dyspnea on day 19 during the first course of GC therapy. Both chest X-ray and computed tomography (CT) images revealed diffuse bilateral interstitial infiltrates. She was diagnosed as having drug-induced interstitial pneumonia. We identified gemcitabine as the causative agent based on the results of examinations (CT, X-ray, KL-6 level, drug lymphocyte stimulation test (DLST)). After three months of steroid therapy, her interstitial pneumonia was completely resolved on CT scans. Although gemcitabine-induced interstitial pneumonia is a rare adverse event, it should be considered a severe complication because delayed diagnosis and treatment can lead to a fatal outcome. Thus, early detection of drug-induced interstitial pneumonia is extremely important during GC therapy.
authors.affiliation: The Department of Urology, Graduate School of Medicine, University of the Ryukyus, Japan.
authors.forename: Eiri
authors.initials: E
authors.lastname: Matsumura
authors.forename: Asuka
authors.initials: A
authors.lastname: Ashikari
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Tasaki
authors.forename: Syusaku
authors.initials: S
authors.lastname: Haranaga
authors.forename: Tomotsune
authors.initials: T
authors.lastname: Toyosato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ashimine
authors.forename: Noriko
authors.initials: N
authors.lastname: Machida
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Oshiro
authors.forename: Seiichi
authors.initials: S
authors.lastname: Saito
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine