title: Self-assembled and nanostructured siRNA delivery systems.
abstract: A wide range of organic and inorganic materials have been used in the development of nano-scale self-assembling gene delivery systems to improve the therapeutic efficacy of nucleic acid drugs. Small interfering RNA (siRNA) has recently been recognized as a promising and potent nucleic acid medicine for the treatment of incurable genetic disorders including cancer; however, siRNA-based therapeutics suffer from the same delivery problems as conventional nucleic acid drugs such as plasmid DNA and antisense oligonucleotides. Many of the delivery strategies developed for nucleic acid drugs have been applied to siRNA therapeutics, but they have not produced satisfactory in vivo gene silencing efficiencies to warrant clinical trials. This review discusses recent progress in the development of self-assembled and nanostructured delivery systems for efficient siRNA-induced gene silencing and their potential application in clinical settings.
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon 440-746, South Korea.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Jeong
authors.forename: Tae Gwan
authors.initials: TG
authors.lastname: Park
authors.forename: Sun Hwa
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000818:Animals; D002412:Cations; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D020868:Gene Silencing / Q000187:drug effects; D006801:Humans; D008055:Lipids / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage; D010316:Particle Size; D010455:Peptides / Q000737:chemistry; D010957:Plasmids / Q000008:administration & dosage; D011092:Polyethylene Glycols / Q000737:chemistry; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D002412:Cations; D004337:Drug Carriers; D008055:Lipids; D016376:Oligonucleotides, Antisense; D010455:Peptides; D034741:RNA, Small Interfering; D011092:Polyethylene Glycols