title: Shape-specific nanofibers via self-assembly of three-branched peptide.
abstract: A novel amphiphilic branched peptide (1), in which three β-sheet formable peptides (L(4)K(8)L(4)) were connected by Lys residue, was newly prepared as a building block for self-assembly. A detailed analysis of the conformation and self-assembling property of 1 in water at various pH conditions was performed by using circular dichroism, FTIR, atomic force and transmission electron microscopies. The experimental results revealed that the branched peptide showed a pH-dependent conformation forming a shape-specific β-sheet-based nanofiber with morphologically kinked structures under specific pH conditions. Exploring a novel peptide building unit that has the ability to self-assemble into designed and complicated nano-objects is valuable to facilitate a bottom-up nanotechnology.
authors.affiliation: Department of Molecular Chemistry & Biochemistry, Faculty of Science & Engineering, Doshisha University, Kyotanabe, Kyoto, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Koga
authors.forename: Harunobu
authors.initials: H
authors.lastname: Matsui
authors.forename: Takahiro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Higashi
mesh_terms: D000595:Amino Acid Sequence; D006863:Hydrogen-Ion Concentration; D007930:Leucine / Q000737:chemistry; D008239:Lysine / Q000737:chemistry; D008969:Molecular Sequence Data; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D010455:Peptides; D013501:Surface-Active Agents; D007930:Leucine; D008239:Lysine