title: Distribution of cytokine gene polymorphisms in Thai population.
abstract: The distribution of 21 cytokine polymorphisms within 13 cytokine and cytokine receptor genes was analyzed in 102 healthy Thai individuals using the LIFECODES Cytokine SNP Typing kit. The TGFB codon25 marker is monomorphic in the Thai population. The IL1B+3962, IL6-174, and TNFA-238 are very rare polymorphisms, with only 0.01-0.04 minor allele frequency (MAF). The IL4-1098, IL1A-889, and IL10-1082 are found only 0.06-0.08 in Thai. Other cytokine polymorphisms (IL1B-511, IL1R pst1 1970, IL1RN mspa1 11100, IL4RA+1902, IL12B-1188, IFNG+874, TGFB codon10, TNFA-308, IL2-330, IL2+166, IL4-590, IL4-33, IL10-819, and IL10-592) in Thai have MAFs more than 0.10, ranging between 0.13 and 0.47. When comparing the allele and genotype frequencies with public single nucleotide polymorphism (SNP) database, most cytokine polymorphisms in Thai show similar distribution to Han Chinese and Japanese, but significantly different from Caucasian and African populations. Only a few markers, including IL4A+1902, TNFA-308, IL1B+3962, and IL2+166 show statistically different distribution among Thai and other Asian populations especially with the Japanese.
authors.affiliation: Medical Microbiology Interdisciplinary Program, Graduate School, Chulalongkorn University, Bangkok, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Sodsai
authors.forename: J
authors.initials: J
authors.lastname: Nakkuntod
authors.forename: P
authors.initials: P
authors.lastname: Kupatawintu
authors.forename: N
authors.initials: N
authors.lastname: Hirankarn
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics; D016207:Cytokines / Q000235:genetics* / Q000378:metabolism*; D030541:Databases, Genetic; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D013785:Thailand
chemical_list: D016207:Cytokines