title: Growth standards of infants with Prader-Willi syndrome.
abstract: OBJECTIVE
  To generate and report standardized growth curves for weight, length, head circumference, weight/length, and BMI for non-growth hormone-treated white infants (boys and girls) with Prader-Willi syndrome (PWS) between 0 and 36 months of age. The goal was to monitor growth and compare data with other infants with PWS.
  
  
  METHODS
  Anthropometric measures (N = 758) were obtained according to standard methods and analyzed from 186 non-growth hormone-treated white infants (108 boys and 78 girls) with PWS between 0 and 36 months of age. Standardized growth curves were developed and the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles were calculated by using the LMS (refers to λ, μ, and σ) smoothing procedure method for weight, length, head circumference, weight/length, and BMI along with the normative 50th percentile using Centers for Disease Control and Prevention national growth data from 2003. The data were plotted for comparison purposes.
  
  
  RESULTS
  Five separate standardized growth curves (weight, length, head circumference, weight/length, and BMI) representing 7 percentile ranges were developed from 186 non-growth hormone-treated white male and female infants with PWS aged 0 to 36 months, and the normative 50th percentile was plotted on each standardized infant growth curve.
  
  
  CONCLUSIONS
  We encourage the use of these growth standards when examining infants with PWS and evaluating growth for comparison purposes, monitoring for growth patterns, nutritional assessment, and recording responses to growth hormone therapy, commonly used in infants and children with PWS.
authors.affiliation: Department of Psychiatry, Kansas University Medical Center, 3901 Rainbow Blvd, MS 4015, Kansas City, KS 66160, USA. mbutler4@kumc.edu
authors.forename: Merlin G
authors.initials: MG
authors.lastname: Butler
authors.forename: Jennifer
authors.initials: J
authors.lastname: Sturich
authors.forename: Jaehoon
authors.initials: J
authors.lastname: Lee
authors.forename: Susan E
authors.initials: SE
authors.lastname: Myers
authors.forename: Barbara Y
authors.initials: BY
authors.lastname: Whitman
authors.forename: June-Anne
authors.initials: JA
authors.lastname: Gold
authors.forename: Virginia
authors.initials: V
authors.lastname: Kimonis
authors.forename: Ann
authors.initials: A
authors.lastname: Scheimann
authors.forename: Norma
authors.initials: N
authors.lastname: Terrazas
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Driscoll
mesh_terms: D000367:Age Factors; D001827:Body Height / Q000187:drug effects / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002508:Cephalometry; D002675:Child, Preschool; D005260:Female; D057238:Growth Charts; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D015596:Nutrition Assessment; D011218:Prader-Willi Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012016:Reference Values; D012737:Sex Factors
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone