title: Fundal changes in children receiving Vigabatrin.
abstract: Visual field defects and other abnormalities are reported in patients receiving the newer antiepileptic Vigabatrin (VGB). Field testing in children younger than 6 years and those with mental retardation is difficult. The authors, therefore, studied ophthalmoscopic abnormalities in seven pediatric patients receiving VGB for median duration of 9 month (range, 3-32 months). Abnormal findings were seen in two (33.3%) in the form of surface wrinkling retinopathy and abnormal macular reflexes. The proportion of abnormal findings was in agreement with previous reports. Thus it is concluded that simple ophthalmoscopy by an ophthalmologist picks up the abnormalities due to ocular toxicity of VGB, and helps in rationalizing further AED therapy in the clinic.
authors.affiliation: Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Delhi 110 029, India. drdmishra@gmail.com
authors.forename: Devendra
authors.initials: D
authors.lastname: Mishra
authors.forename: Veena
authors.initials: V
authors.lastname: Kalra
authors.forename: Pradeep
authors.initials: P
authors.lastname: Venkatesh
authors.forename: Rachna
authors.initials: R
authors.lastname: Seth
authors.forename: Sheffali
authors.initials: S
authors.lastname: Gulati
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D009887:Ophthalmoscopy; D011446:Prospective Studies; D012164:Retinal Diseases / Q000139:chemically induced*; D020888:Vigabatrin / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D020888:Vigabatrin