title: Early antiviral response and virus-induced genes in fish.
abstract: In fish as in mammals, virus infections induce changes in the expression of many host genes. Studies conducted during the last fifteen years revealed a major contribution of the interferon system in fish antiviral response. This review describes the screening methods applied to compare the impact of virus infections on the transcriptome in different fish species. These approaches identified a "core" set of genes that are strongly induced in most viral infections. The "core" interferon-induced genes (ISGs) are generally conserved in vertebrates, some of them inhibiting a wide range of viruses in mammals. A selection of ISGs -PKR, vig-1/viperin, Mx, ISG15 and finTRIMs - is further analyzed here to illustrate the diversity and complexity of the mechanisms involved in establishing an antiviral state. Most of the ISG-based pathways remain to be directly determined in fish. Fish ISGs are often duplicated and the functional specialization of multigenic families will be of particular interest for future studies.
authors.affiliation: INRA, Fish Infection and Immunity, Molecular Virology and Immunology, Domaine de Vilvert, 78352 Jouy en Josas, France.
authors.forename: Eloi R
authors.initials: ER
authors.lastname: Verrier
authors.forename: Christelle
authors.initials: C
authors.lastname: Langevin
authors.forename: Abdenour
authors.initials: A
authors.lastname: Benmansour
authors.forename: Pierre
authors.initials: P
authors.lastname: Boudinot
mesh_terms: D000818:Animals; D005393:Fish Diseases / Q000276:immunology* / Q000821:virology; D029941:Fish Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D005399:Fishes / Q000235:genetics / Q000276:immunology / Q000821:virology*; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation / Q000276:immunology; D007113:Immunity, Innate; D007372:Interferons / Q000276:immunology*; D011494:Protein Kinases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D014452:Ubiquitins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology; D014780:Viruses / Q000276:immunology*
chemical_list: D029941:Fish Proteins; D014452:Ubiquitins; D007372:Interferons; D044767:Ubiquitin-Protein Ligases; D011494:Protein Kinases; D020558:GTP Phosphohydrolases