title: Ancient melanocytic nevus: a simulator of malignant melanoma.
abstract: Ancient melanocytic nevus (AN) is an unusual but distinctive melanocytic neoplasm within the spectrum of simulators of malignant melanoma. This report describes 13 patients with AN where a long follow-up information was available. Histopathology is characterized by 2 populations of melanocytes, namely, one with large pleomorphic cells and the other with small melanocytes. A few mitotic figures may be present exceptionally. MIB-1 (Ki67) proliferation marker reveals an overall low nuclear labeling index. Additional important findings are stromal degenerative changes. AN must be especially differentiated from dermal melanoma arising in a nevus.
authors.affiliation: Department of Dermatology, Medical University of Graz, Graz, Austria. helmut.kerl@meduni-graz.at
authors.forename: Helmut
authors.initials: H
authors.lastname: Kerl
authors.forename: Ingrid H
authors.initials: IH
authors.lastname: Wolf
authors.forename: Katrin
authors.initials: K
authors.lastname: Kerl
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cerroni
authors.forename: Heinz
authors.initials: H
authors.lastname: Kutzner
authors.forename: Zsolt B
authors.initials: ZB
authors.lastname: Argenyi
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D055815:Young Adult
chemical_list: D019394:Ki-67 Antigen