title: Hepatobiliary response in postoperative lipid therapy in gastrointestinal surgery.
abstract: OBJECTIVE
  Intravenous lipid emulsions may contribute to the development of total parenteral nutrition (TPN)--induced hepatobiliary complications.
  
  
  METHODS
  In a prospective, randomised setting the authors compared the short-term hepatic effects of medium-chain triglycerides/short-chain triglycerides (MCT/LCT) physical mixture with a four-component intravenous (i.v.) lipid emulsion (LCT, MCT, Olive-oil and Fish-oil) in patients undergoing elective gastrointestial surgery during the early postoperative period.
  
  
  RESULTS
  The authors demonstrated that total and conjugated bilirubin, alkaline phosphatase, alanine aminotransferase, aspartate amino transferase and cholinesterase did not change significantly during the 5-days observation period. In contrast to this, gamma-glutamyl transferase (GGT) activity increased by 2,4 times during 5-days therapy with the lipid emulsions mentioned above (SMOF lipid: 21,9 to 52,9 U/L, Lipofundin: from 32,5 to 79,6 U/L).
  
  
  CONCLUSIONS
  during a 4-days administration hepatic effect of the intravenous lipid emulsions did not differ significantly. The changes in enzyme levels confirm the cholestatic type of hepatobiliary deviations without clinical impact on short-term TPN therapy.
authors.affiliation: Department of Anaesthesiology and Intensive Care, University of Debrecen, Medical & Health Science Center, Nagyerdei krt.98. Debrecen, Hungary. jhallay@dote.hu
authors.forename: Judit
authors.initials: J
authors.lastname: Hallay
authors.forename: Anna V
authors.initials: AV
authors.lastname: Olah
authors.forename: Bela
authors.initials: B
authors.lastname: Fulesdi
authors.forename: Marta
authors.initials: M
authors.lastname: Kocsor
authors.forename: Tamas
authors.initials: T
authors.lastname: Vegh
authors.forename: Gabor
authors.initials: G
authors.lastname: Kovacs
authors.forename: Istvan
authors.initials: I
authors.lastname: Takacs
authors.forename: Peter
authors.initials: P
authors.lastname: Sapy
authors.forename: Daniel
authors.initials: D
authors.lastname: Nagy
authors.forename: Istvan G
authors.initials: IG
authors.lastname: Telessy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects*; D005260:Female; D041981:Gastrointestinal Tract / Q000601:surgery*; D006801:Humans; D008107:Liver Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D011184:Postoperative Period; D011446:Prospective Studies; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D005217:Fat Emulsions, Intravenous; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase