title: Palladium-catalyzed tandem reaction to construct benzo[c]phenanthridine: application to the total synthesis of benzo[c]phenanthridine alkaloids.
abstract: A concise and efficient synthesis of benzo[c]phenanthridines was accomplished by the palladium-catalyzed ring-opening coupling of azabicyclic alkene with o-iodobenzoates, followed by tandem cyclization. The strategy was successfully applied in the total synthesis of benzo[c]phenanthridine alkaloids such as sanguinarine, chelerythrine, nitidine and avicine.
authors.affiliation: State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Pei
authors.initials: P
authors.lastname: Lv
authors.forename: Kanglun
authors.initials: K
authors.lastname: Huang
authors.forename: Longguan
authors.initials: L
authors.lastname: Xie
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Xu
mesh_terms: D053119:Benzophenanthridines / Q000138:chemical synthesis*; D002384:Catalysis; D007463:Iodobenzoates / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D053119:Benzophenanthridines; D007463:Iodobenzoates; D010165:Palladium