title: Fetal stress hormone changes during intrauterine transfusions.
abstract: OBJECTIVE
  To document fetal stress hormone and Doppler changes after intrauterine transfusions (IUTs) in either the intrahepatic portion of the umbilical vein (IHV) or the placental cord insertion (PCI).
  
  
  METHODS
  Pregnant women scheduled for IUT for fetal anemia (N = 25) were included prospectively. Cortisol, β-endorphin and noradrenalin concentrations in fetal plasma and middle cerebral artery pulsatility index before and after transfusion were compared. Transfusions were performed through the (IHV), thus puncturing the fetus, or at the PCI.
  
  
  RESULTS
  There were no measurable differences between the transfusion sites.
  
  
  CONCLUSIONS
  In anemic fetuses undergoing transfusion, Doppler changes and fetal stress hormone changes were unrelated to the site of needle insertion.
authors.affiliation: Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands. p.n.adama_van_scheltema@lumc.nl
authors.forename: P N
authors.initials: PN
authors.lastname: Adama van Scheltema
authors.forename: S A
authors.initials: SA
authors.lastname: Pasman
authors.forename: R
authors.initials: R
authors.lastname: Wolterbeek
authors.forename: J A
authors.initials: JA
authors.lastname: Deprest
authors.forename: D
authors.initials: D
authors.lastname: Oepkes
authors.forename: F
authors.initials: F
authors.lastname: De Buck
authors.forename: M
authors.initials: M
authors.lastname: Van de Velde
authors.forename: F P H A
authors.initials: FP
authors.lastname: Vandenbussche
mesh_terms: D000740:Anemia / Q000151:congenital / Q000628:therapy*; D018686:Anesthetics, Intravenous; D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects; D005260:Female; D005312:Fetal Blood / Q000737:chemistry / Q000378:metabolism; D005315:Fetal Diseases / Q000097:blood / Q000378:metabolism / Q000628:therapy*; D005333:Fetus / Q000378:metabolism*; D006305:Health Status Indicators; D006728:Hormones / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis / Q000097:blood / Q000378:metabolism; D020768:Middle Cerebral Artery / Q000502:physiology; D009638:Norepinephrine / Q000032:analysis / Q000097:blood / Q000378:metabolism; D010880:Piperidines / Q000008:administration & dosage; D010919:Placebos; D011247:Pregnancy; D011673:Pulsatile Flow / Q000502:physiology; D000077208:Remifentanil; D013312:Stress, Physiological / Q000502:physiology*; D001615:beta-Endorphin / Q000032:analysis / Q000097:blood / Q000378:metabolism
chemical_list: D018686:Anesthetics, Intravenous; D006728:Hormones; D010880:Piperidines; D010919:Placebos; D001615:beta-Endorphin; D000077208:Remifentanil; D006854:Hydrocortisone; D009638:Norepinephrine