title: [Early stimulation in newborns with birth weight between 1,000 and 1,500 g: is it always necessary?].
abstract: OBJECTIVE
  To determine whether the currently widespread practice of sending all premature infants with birth weight between 1,000 and 1,500 g to early care centres is necessary from a neurological point of view, or if it is possible to establish selection criteria.
  
  
  METHODS
  A retrospective study of newborns (NB) at our hospital between January 1998 and December 2004 with birth weight between 1,000 and 1,500 g, and followed up for at least two years in a paediatric neurology clinic. We analysed the prognostic significance of the different neurological variables in the neonatal period, and those of greater significance were set at a score for deciding the start of early stimulation treatment on discharge from neonatology.
  
  
  RESULTS
  A total of 194 infants met the above criteria. The most significant neurological prognostic variables were: gestational age < 28 weeks, male sex, intraventricular haemorrhage grade > I, history of high risk pregnancy, sepsis, anaemia with haemodynamic repercussion and fundamentally abnormal neurological examination at discharge (odds ratio of 16). A prognostic score was developed with a cut-off of 4 points, with an area under the curve of 88.3%. The positive predictive value and negative predictive value were 43.75% and 96.2%, respectively, with 84.8% sensitivity and 78.9% specificity.
  
  
  CONCLUSIONS
  The newborns with birth weight between 1,000 and 1,500 g and normal neurological examination at discharge, with a score of less than 4 points, do not require early stimulation treatment from a neurological standpoint, given its predictable good outcome.
authors.affiliation: Departamento de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, España. alexrodriguezog@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez Ogando
authors.forename: M C
authors.initials: MC
authors.lastname: Miranda Herrero
authors.forename: P
authors.initials: P
authors.lastname: Castro de Castro
authors.forename: M
authors.initials: M
authors.lastname: Vázquez López
authors.forename: D
authors.initials: D
authors.lastname: Blanco Bravo
mesh_terms: D061345:Early Medical Intervention; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D012189:Retrospective Studies