title: A new quinoline derivative with cytotoxic activity from Streptomyces sp. neau50.
abstract: A new quinoline derivative, methyl 8-(3-methoxy-3-methylbutyl)-2-methylquinoline-4-carboxylate (1), was isolated from the endophytic strain Streptomyces sp. neau50, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human lung adenocarcinoma cell line A549 with an IC(50) value of 29.3 μg mL(-1).
authors.affiliation: School of Life Science, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Xiang-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Dian-Liang
authors.initials: DL
authors.lastname: Gong
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Wang
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Chong-Xi
authors.initials: CX
authors.lastname: Liu
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Xiang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011804:Quinolines; C559409:methyl 8-(3-methoxy-3-methylbutyl)-2-methylquinoline-4-carboxylate; C037219:quinoline