title: Chisomicines A-C, limonoids from Chisocheton ceramicus.
abstract: Three new limonoids, chisomicines A-C (1-3), have been isolated from the bark of Chisocheton ceramicus. Their structures were determined by 2D NMR, CD spectroscopic methods, and X-ray analysis. Chisomicine A (1) exhibited NO production inhibitory activity in J774.1 cells stimulated by LPS dose-dependently at high cell viability.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Ibrahim A
authors.initials: IA
authors.lastname: Najmuldeen
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: Khalit
authors.initials: K
authors.lastname: Mohamad
authors.forename: Kamal Aziz
authors.initials: KA
authors.lastname: Ketuly
authors.forename: Mat Ropi
authors.initials: MR
authors.lastname: Mukhtar
authors.forename: Soon-Lim
authors.initials: SL
authors.lastname: Chong
authors.forename: Gomathi
authors.initials: G
authors.lastname: Chan
authors.forename: Mohd Azlan
authors.initials: MA
authors.lastname: Nafiah
authors.forename: Ng Seik
authors.initials: NS
authors.lastname: Weng
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirota
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hosoya
authors.forename: Alfarius E
authors.initials: AE
authors.lastname: Nugroho
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008296:Malaysia; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D019323:omega-N-Methylarginine / Q000494:pharmacology
chemical_list: D036701:Limonins; D008070:Lipopolysaccharides; C560179:chisomicine A; C560180:chisomicine B; C560181:chisomicine C; D019323:omega-N-Methylarginine; D009569:Nitric Oxide