title: Increasing synthetic efficiency via direct C-H functionalization: formal synthesis of an inhibitor of botulinum neurotoxin.
abstract: A new and efficient scheme for the synthesis of one of the best known inhibitors of botulinum neurotoxin serotype A (BoNTA) is reported herein. The synthetic route involves two palladium-catalyzed C-H functionalization reactions, formally activating three C-H bonds.
authors.affiliation: Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, RI 02881, USA.
authors.forename: Shathaverdhan
authors.initials: S
authors.lastname: Potavathri
authors.forename: Abhishek
authors.initials: A
authors.lastname: Kantak
authors.forename: Brenton
authors.initials: B
authors.lastname: DeBoef
mesh_terms: D019274:Botulinum Toxins, Type A / Q000037:antagonists & inhibitors*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D009942:Organometallic Compounds; D013876:Thiophenes; D010165:Palladium; D019274:Botulinum Toxins, Type A