title: Hydrogen peroxide vapour (HPV) inactivation of adenovirus.
abstract: OBJECTIVE
  Adenovirus contamination can be problematic in various settings including life science laboratories and during pharmaceutical manufacturing processes. Stringent and effective decontamination procedures are necessary to minimize the risk of personnel exposure or product cross-contamination in these settings. Hydrogen peroxide vapour (HPV) is sporicidal, tuberculocidal and fungicidal with proven efficacy against some viruses. We investigate the efficacy of HPV for the inactivation of a recombinant adenovirus.
  
  
  RESULTS
  In this study, the survival of a dried recombinant adenovirus (Ad5GFP) was tested before and after HPV exposure to determine the efficacy of HPV at inactivating adenovirus. A>8-log TCID(50) reduction resulted from 45-min exposure to HPV in a microbiological safety cabinet.
  
  
  CONCLUSIONS
  HPV is effective for the inactivation of a recombinant adenovirus.
  
  
  CONCLUSIONS
  The results suggest that HPV may be useful for adenovirus decontamination in life science laboratories or in manufacturing facilities.
authors.affiliation: Clinical BioManufacturing Facility, University of Oxford, Oxford, UK.
authors.forename: E
authors.initials: E
authors.lastname: Berrie
authors.forename: L
authors.initials: L
authors.lastname: Andrews
authors.forename: S
authors.initials: S
authors.lastname: Yezli
authors.forename: J A
authors.initials: JA
authors.lastname: Otter
mesh_terms: D000256:Adenoviridae / Q000187:drug effects*; D000998:Antiviral Agents / Q000494:pharmacology*; D003666:Decontamination / Q000379:methods*; D006861:Hydrogen Peroxide / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D006861:Hydrogen Peroxide