title: High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams.
abstract: Conventional Fourier-transform infrared (FTIR) microspectroscopic systems are limited by an inevitable trade-off between spatial resolution, acquisition time, signal-to-noise ratio (SNR) and sample coverage. We present an FTIR imaging approach that substantially extends current capabilities by combining multiple synchrotron beams with wide-field detection. This advance allows truly diffraction-limited high-resolution imaging over the entire mid-infrared spectrum with high chemical sensitivity and fast acquisition speed while maintaining high-quality SNR.
authors.affiliation: Department of Physics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Nasse
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Walsh
authors.forename: Eric C
authors.initials: EC
authors.lastname: Mattson
authors.forename: Ruben
authors.initials: R
authors.lastname: Reininger
authors.forename: André
authors.initials: A
authors.lastname: Kajdacsy-Balla
authors.forename: Virgilia
authors.initials: V
authors.lastname: Macias
authors.forename: Rohit
authors.initials: R
authors.lastname: Bhargava
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Hirschmugl
mesh_terms: D001940:Breast / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D008853:Microscopy / Q000295:instrumentation / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D013194:Staining and Labeling; D017356:Synchrotrons