title: Segmental blood flow and hemodynamic state of lymphedematous and nonlymphedematous arms.
abstract: BACKGROUND
  Findings regarding the influence hemodynamic factors, such as increased arterial blood flow or venous abnormalities, on breast cancer treatment-related lymphedema are mixed. The purpose of this study was to compare segmental arterial blood flow, venous blood return, and blood volumes between breast cancer survivors with treatment-related lymphedema and healthy normal individuals without lymphedema.
  
  
  RESULTS
  A Tetrapolar High Resolution Impedance Monitor and Cardiotachometer were used to compare segmental arterial blood flow, venous blood return, and blood volumes between breast cancer survivors with treatment-related lymphedema and healthy normal volunteers. Average arterial blood flow in lymphedema-affected arms was higher than that in arms of healthy normal volunteers or in contralateral nonlymphedema affected arms. Time of venous outflow period of blood flow pulse was lower in lymphedema-affected arms than in healthy normal or lymphedema nonaffected arms. Amplitude of the venous component of blood flow pulse signal was lower in lymphedema-affected arms than in healthy or lymphedema nonaffected arms. Index of venular tone was also lower in lymphedema-affected arms than healthy or lymphedema nonaffected arms.
  
  
  CONCLUSIONS
  Both arterial and venous components may be altered in the lymphedema-affected arms when compared to healthy normal arms and contralateral arms in the breast cancer survivors.
authors.affiliation: LDM Associates, San Jose, California, USA.
authors.forename: Leslie D
authors.initials: LD
authors.lastname: Montgomery
authors.forename: Mary S
authors.initials: MS
authors.lastname: Dietrich
authors.forename: Jane M
authors.initials: JM
authors.lastname: Armer
authors.forename: B R
authors.initials: BR
authors.lastname: Stewart
authors.forename: Sheila H
authors.initials: SH
authors.lastname: Ridner
mesh_terms: D000328:Adult; D001132:Arm / Q000098:blood supply* / Q000503:physiopathology*; D001158:Arteries / Q000503:physiopathology; D001943:Breast Neoplasms / Q000150:complications; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008209:Lymphedema / Q000209:etiology / Q000503:physiopathology*; D008875:Middle Aged; D012039:Regional Blood Flow; D014680:Veins / Q000503:physiopathology