title: Synthesis of coumestan derivatives via FeCl3-mediated oxidative ring closure of 4-hydroxy coumarins.
abstract: A concise and efficient approach to the syntheses of coumestan analogues has been developed. The underpinning strategy involves a FeCl(3)-mediated direct intramolecular oxidative annellation of 4-hydroxy-3-phenyl-2H-chromen-2-one derivatives. Utilizing this synthetic protocol, a variety of coumestan derivatives were conveniently obtained from readily available reagents.
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Tang
authors.forename: Yongle
authors.initials: Y
authors.lastname: Pang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Yan
authors.forename: Liuqing
authors.initials: L
authors.lastname: Shi
authors.forename: Jianhui
authors.initials: J
authors.lastname: Huang
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Du
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis*; D002712:Chlorides / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis*; D005290:Ferric Compounds / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry / Q000600:supply & distribution; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D001688:Biological Products; D002712:Chlorides; D003374:Coumarins; D005290:Ferric Compounds; D007202:Indicators and Reagents; C505898:coumestan; C024555:ferric chloride