title: Effects of pericardial constraint and ventricular interaction on left ventricular hemodynamics in the unloaded heart.
abstract: Pericardial constraint and ventricular interaction influence left ventricular (LV) performance when preload is high. However, it is unclear if these constraining forces modulate LV filling when the heart is unloaded, such as during upright posture, in humans. Fifty healthy individuals underwent right heart catheterization to measure pulmonary capillary wedge (PCWP) and right atrial pressure (RAP). To evaluate the effects of pericardial constraint on hemodynamics, transmural filling pressure (LVTMP) was defined as PCWP-RAP. Beat-to-beat blood pressure (BP) waveforms were recorded, and stroke volume (SV) was derived from the Modelflow method. After measurements at -30 mmHg lower body negative pressure (LBNP), which approximates the upright position, LBNP was released, and beat-to-beat measurements were performed for 15 heartbeats. At -30 mmHg LBNP, RAP and PCWP were significantly decreased. During the first six beats of LBNP release, heart rate (HR) was unchanged, while BP increased from the fourth beat. RAP increased faster than PCWP resulting in an acute decrease in LVTMP from the fourth beat. A corresponding drop in SV by 3% was observed with no change in pulse pressure. From the 7th to 15th beats, LVTMP and SV increased steadily, followed by a decreased HR due to the baroreflex. A decreased TMP, but not PCWP, caused a transient drop in SV with no changes in HR or pulse pressure during LBNP release. These results suggest that the pericardium constrains LV filling during LBNP release, enough to cause a small but significant drop of SV, even at low cardiac filling pressure in healthy humans.
authors.affiliation: Institute for Exercise and Environmental Medicine, Dallas, TX 75231, USA.
authors.forename: Naoki
authors.initials: N
authors.lastname: Fujimoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Shibata
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Hastings
authors.forename: Graeme
authors.initials: G
authors.lastname: Carrick-Ranson
authors.forename: Paul S
authors.initials: PS
authors.lastname: Bhella
authors.forename: Dean
authors.initials: D
authors.lastname: Palmer
authors.forename: Qi
authors.initials: Q
authors.lastname: Fu
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Levine
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D006328:Cardiac Catheterization; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008150:Lower Body Negative Pressure / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*