title: An effective method to prepare imines from aldehyde, bromide/epoxide, and aqueous ammonia.
abstract: A three-component reaction of aldehydes, alkyl bromides, and ammonia to form imines was studied. Aqueous ammonia was applied as the nitrogen source and solvent in the reaction. For the aromatic aldehyde, the product yields are good to excellent and the reaction conditions are mild to be compatible with a range of functional groups. The reaction of aldehydes and aqueous ammonia with epoxides was also studied and imines bearing a vicinal hydroxyl group can be obtained efficiently and regioselectively. And studies showed that this method allows the synthesis of primary amines and especially 1,2-amino alcohol selectively in high yield. It is proposed that the reaction pathway might involve a key intermediate of hydrobenzamide.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China. chehjm@scut.edu.cn
authors.forename: Jing-Mei
authors.initials: JM
authors.lastname: Huang
authors.forename: Jue-Fei
authors.initials: JF
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
authors.forename: Wen
authors.initials: W
authors.lastname: Gong
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000641:Ammonia / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D001965:Bromides; D004852:Epoxy Compounds; D007097:Imines; D014867:Water; D000641:Ammonia