title: Feasibility of diastolic function assessment with cardiac CT: feasibility study in comparison with tissue Doppler imaging.
abstract: OBJECTIVE
  This study aimed to demonstrate the feasibility of multidetector row computed tomography (CT) for assessment of diastolic function in comparison with 2-dimensional (2D) echocardiography using tissue Doppler imaging (TDI).
  
  
  BACKGROUND
  Diastolic left ventricular (LV) function plays an important role in patients with cardiovascular disease. 2D echocardiography using TDI has been used most commonly to evaluate diastolic LV function. Although the role of cardiac CT imaging for evaluation of coronary atherosclerosis has been explored extensively, its feasibility to evaluate diastolic function has not been studied.
  
  
  METHODS
  Patients who had undergone 64-multidetector row CT and 2D echocardiography with TDI were enrolled. Diastolic function was evaluated using early (E) and late (A) transmitral peak velocity (cm/s) and peak mitral septal tissue velocity (Ea; cm/s). Peak transmitral velocity (cm/s) was calculated by dividing peak diastolic transmitral flow (ml/s) by the corresponding mitral valve area (cm(2)). Mitral septal tissue velocity was calculated from changes in LV length per cardiac phase. Subsequently, the estimation of LV filling pressures (E/Ea) was determined.
  
  
  RESULTS
  Seventy patients (46 men; mean age 55 ± 11 years) who had undergone cardiac CT and 2D echocardiography with TDI were included. Good correlations were observed between cardiac CT and 2D echocardiography for assessment of E (r = 0.73; p < 0.01), E/A (r = 0.87; p < 0.01), Ea (r = 0.82; p < 0.01), and E/Ea (r = 0.81; p < 0.01). Moreover, a good diagnostic accuracy (79%) was found for detection of diastolic dysfunction using cardiac CT. Finally, the study showed a low intraobserver and interobserver variability for assessment of diastolic function on cardiac CT.
  
  
  CONCLUSIONS
  Cardiac CT imaging showed good correlations for transmitral velocity, mitral septal tissue velocity, and estimation of LV filling pressures when compared with 2D echocardiography. Additionally, cardiac CT and 2D echocardiography were comparable for assessment of diastolic dysfunction. Accordingly, cardiac CT may provide information on diastolic dysfunction.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Boogers
authors.forename: Jacob M
authors.initials: JM
authors.lastname: van Werkhoven
authors.forename: Joanne D
authors.initials: JD
authors.lastname: Schuijf
authors.forename: Victoria
authors.initials: V
authors.lastname: Delgado
authors.forename: Heba M
authors.initials: HM
authors.lastname: El-Naggar
authors.forename: Eric
authors.initials: E
authors.lastname: Boersma
authors.forename: Gaetano
authors.initials: G
authors.lastname: Nucifora
authors.forename: Rob J
authors.initials: RJ
authors.lastname: van der Geest
authors.forename: Bernard P
authors.initials: BP
authors.lastname: Paelinck
authors.forename: Lucia J
authors.initials: LJ
authors.lastname: Kroft
authors.forename: Johan H C
authors.initials: JH
authors.lastname: Reiber
authors.forename: Albert
authors.initials: A
authors.lastname: de Roos
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
authors.forename: Hildo J
authors.initials: HJ
authors.lastname: Lamb
mesh_terms: D000328:Adult; D000368:Aged; D003971:Diastole; D018618:Echocardiography, Doppler, Color; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D015588:Observer Variation; D011237:Predictive Value of Tests; D012042:Registries; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016277:Ventricular Function, Left