title: [The role of biliary decompression and correction of dysbiosis in the treatment of obstructive jaundice].
abstract: The article providing in-depth analysis of pathogenesis of obstructive jaundice shows that this disease is manifest not only as changes at the hepatic level (cholestasis, cholehemia, cholangitis, cholangio- and lymphovenous shunts, hepatic encephalopathy) but also as marked dysbiotic disturbances due to anacholia and toxic metabolites that cause bacterial translocation and endotoxemia complicating liver insufficiency. Based on the literary data and original observations, a new scheme for the treatment of obstructive jaundice is proposed including simultaneous correction of both components of hepatoenteric turnover, also, it permits to improve the outcome of the postoperative period.
authors.forename: E M
authors.initials: EM
authors.lastname: Lipnitskiĭ
authors.forename: É I
authors.initials: ÉI
authors.lastname: Gal'perin
authors.forename: A E
authors.initials: AE
authors.lastname: Kotovskiĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Chzhao
authors.forename: V G
authors.initials: VG
authors.lastname: Istratov
authors.forename: S A
authors.initials: SA
authors.lastname: Bekbauov
mesh_terms: D018988:Bacterial Translocation / Q000502:physiology*; D002761:Cholangitis / Q000209:etiology / Q000378:metabolism / Q000382:microbiology* / Q000503:physiopathology; D002779:Cholestasis / Q000209:etiology / Q000378:metabolism / Q000382:microbiology* / Q000503:physiopathology; D003131:Combined Modality Therapy; D019299:Decompression, Surgical / Q000009:adverse effects; D004731:Endotoxins / Q000097:blood*; D005766:Gastrointestinal Contents / Q000382:microbiology*; D048550:Hepatic Insufficiency / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology; D006801:Humans; D041781:Jaundice, Obstructive / Q000150:complications / Q000378:metabolism / Q000382:microbiology* / Q000503:physiopathology / Q000628:therapy; D011183:Postoperative Complications / Q000401:mortality; D016060:Sorption Detoxification / Q000009:adverse effects
chemical_list: D004731:Endotoxins