title: Clinical profile of distal renal tubular acidosis.
abstract: To determine the clinical profile and progression of renal dysfunction in distal renal tubular acidosis (dRTA), we retrospectively studied 96 consecutive cases of dRTA diagnosed at our center. Patients with unexplained metabolic bone disease, short stature, hypokalemia, re-current renal stones, chronic obstructive uropathy or any primary autoimmune condition known to cause dRTA were screened. Distal RTA was diagnosed on the basis of systemic metabolic acidosis with urine pH >5.5 and positive urine anion gap. In those patients who had fasting urine pH >5.5 with normal baseline systemic pH and bicarbonate levels (incomplete RTA), acid load test with ammonium chloride was done. A cause of dRTA could be established in 53 (54%) patients. Urological defect in children (22/44) and autoimmune disease in adults (11/52) were the commonest causes. Hypokalemic paralysis, proximal muscle weakness and voiding difficulty were the common modes of presentation. Doubling of serum creatinine during the study period was noted in 13 out of 27 patients who had GFR <60 mL/min at presentation whereas in only one of the 70 with initial GFR >60 mL/min (P <0.005). In conclusion, urological disorders were the commonest cause of dRTA in children while autoimmune disorders were the commonest asso-ciation in adults. Worse baseline renal function, longer duration of disease and greater frequency of nephrolithiasis/nephrocalcinosis and urological disorders were noted in those who had wor-sening of renal dysfunction during the study period.
authors.affiliation: Department of Endocrinology, Medwin Hospital, Hyderabad, India.
authors.forename: Ratan
authors.initials: R
authors.lastname: Jha
authors.forename: J
authors.initials: J
authors.lastname: Muthukrishnan
authors.forename: Shekhar
authors.initials: S
authors.lastname: Shiradhonkar
authors.forename: Kiran
authors.initials: K
authors.lastname: Patro
authors.forename: Kvs
authors.initials: K
authors.lastname: Harikumar
authors.forename: K D
authors.initials: KD
authors.lastname: Modi
mesh_terms: D000136:Acid-Base Equilibrium; D000141:Acidosis, Renal Tubular / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000652:urine; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001639:Bicarbonates / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002118:Calcium / Q000652:urine; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007194:India / Q000453:epidemiology; D007223:Infant; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016482:Urinalysis; D055815:Young Adult
chemical_list: D001639:Bicarbonates; D015415:Biomarkers; D003404:Creatinine; D002118:Calcium