title: Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography.
abstract: Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO(2)) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO(2) levels in a blood vessel phantom. DWP OCT SaO(2) is linearly correlated with blood-gas SaO(2) measurements. We demonstrate 6.3% precision in SaO(2) levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO(2) levels measured with DWP-OCT are identified and characterized.
authors.forename: Roman V
authors.initials: RV
authors.lastname: Kuranov
authors.forename: Jinze
authors.initials: J
authors.lastname: Qiu
authors.forename: Austin B
authors.initials: AB
authors.lastname: McElroy
authors.forename: Arnold
authors.initials: A
authors.lastname: Estrada
authors.forename: Anthony
authors.initials: A
authors.lastname: Salvaggio
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kiel
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Dunn
authors.forename: Timothy Q
authors.initials: TQ
authors.lastname: Duong
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Milner