title: Management of phototherapy for neonatal hyperbilirubinemia: is a new radiometer applicable for all wavelengths and light source types?
abstract: BACKGROUND
  To evaluate the clinical effects of phototherapy for neonatal hyperbilirubinemia, it is necessary to measure the rate of cyclobilirubin production, which represents the main photochemical pathway of bilirubin metabolism. Since the Atom Phototherapy Analyzer can be used to calculate the theoretical relative light energy of irradiance as a means of assessing the cyclobilirubin production rate for each wavelength spectrum, the clinical effect of phototherapy can be evaluated regardless of the light source type. Using the Atom Phototherapy Analyzer, the correlation between the irradiance of various light sources with different peak wavelengths and the rate of cyclobilirubin production was investigated in vitro. We also investigated the utility of green LED in vitro.
  
  
  METHODS
  A bilirubin-albumin complex solution was prepared, poured into tubes, and irradiated using various light sources. All light sources used were bed-type phototherapy devices; that is, green and blue LED and green and blue fluorescence tubes. The concentrations of photoisomers were measured after irradiation and compared with the irradiance of the light sources.
  
  
  RESULTS
  The irradiance measured by the Atom Phototherapy Analyzer decreased in the following order: blue fluorescence tube > green LED > blue LED > green fluorescence tube. The cyclobilirubin production rates and irradiance values of the light sources were significantly positively correlated (R(2) = 0.93, P < 0.05).
  
  
  CONCLUSIONS
  Our data indicate that the Atom Phototherapy Analyzer can be used to objectively evaluate the effects of phototherapy using various light sources. Further, the effects of green LED were similar to those of other light sources in vitro.
authors.affiliation: Maternal Perinatal Center, Faculty of MedicineDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Kuboi
authors.affiliation: Maternal Perinatal Center, Faculty of MedicineDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusaka
authors.affiliation: Maternal Perinatal Center, Faculty of MedicineDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Saneyuki
authors.initials: S
authors.lastname: Yasuda
authors.affiliation: Maternal Perinatal Center, Faculty of MedicineDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Okubo
authors.affiliation: Maternal Perinatal Center, Faculty of MedicineDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Isobe
authors.affiliation: Maternal Perinatal Center, Faculty of MedicineDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Itoh
mesh_terms: D001663:Bilirubin / Q000031:analogs & derivatives / Q000528:radiation effects; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal; D007231:Infant, Newborn; D010789:Phototherapy / Q000295:instrumentation*; D011874:Radiometry / Q000295:instrumentation*; D012709:Serum Albumin / Q000528:radiation effects; D000075462:Serum Albumin, Human
chemical_list: D012709:Serum Albumin; C053498:albumin-bilirubin complex; C041079:cyclobilirubin; D001663:Bilirubin; D000075462:Serum Albumin, Human