title: Kabiramides J and K, trisoxazole macrolides from the sponge Pachastrissa nux.
abstract: Three trisoxazole macrolides possessing a 30-α,β-enone moiety, including the known kabiramide G (1) and the new kabiramides J (2) and K (3), were isolated from the sponge Pachastrissa nux, along with the previously reported kabiramides B (4), C (5), and D (6). To date, the enone moiety has been found to associate solely with the trisoxazole macrolides from P. nux. All of the isolated macrolides showed moderate to strong antimalarial and cytotoxic activities, except for 1, which possessed only potent cytotoxicity.
authors.affiliation: Marine Natural Products Research Unit (MNP), Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
authors.forename: Thanchanok
authors.initials: T
authors.lastname: Sirirak
authors.forename: Siriporn
authors.initials: S
authors.lastname: Kittiwisut
authors.forename: Chittrawan
authors.initials: C
authors.lastname: Janma
authors.forename: Supreeya
authors.initials: S
authors.lastname: Yuenyongsawad
authors.forename: Khanit
authors.initials: K
authors.lastname: Suwanborirux
authors.forename: Anuchit
authors.initials: A
authors.lastname: Plubrukarn
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; D018942:Macrolides; D010080:Oxazoles; C112787:kabiramide D; C560177:kabiramide J; C560178:kabiramide K