title: Patterned resonance plasmonic microarrays for high-performance SPR imaging.
abstract: We report a novel optical platform based on SPR generation and confinement inside a defined three-dimensional microwell geometry that leads to background resonance-free SPR images. The array shows an exceptionally high signal-to-noise ratio (S/N > 80) for imaging analysis and subnanometric thickness resolution. An angular sensitivity of 1°/0.01 RIU has been achieved and the signal to background ratio (S/B) improves to 20, 1 order of magnitude higher than that of the best literature results. The design proves effective for probing-supported lipid membrane arrays in real time with a thickness resolution of 0.24 nm and allows for imaging analysis of microfluidic circuits where resonant spots are separated by only one pixel (∼7 μm). The high image quality and unique chip geometry open up new avenues for array screening and biomicrofluidics using SPRi detection.
authors.affiliation: Department of Chemistry, University of California, Riverside, California 92521, USA.
authors.forename: Abdennour
authors.initials: A
authors.lastname: Abbas
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Linman
authors.forename: Quan
authors.initials: Q
authors.lastname: Cheng
mesh_terms: D004867:Equipment Design; D008051:Lipid Bilayers / Q000737:chemistry; D008567:Membranes, Artificial; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D010316:Particle Size; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods*; D013499:Surface Properties
chemical_list: D008051:Lipid Bilayers; D008567:Membranes, Artificial