title: Canine Leishmania infantum enzymatic polymorphism: a review including 1023 strains of the Mediterranean area, with special reference to Algeria.
abstract: This bibliographic review reports the isoenzyme polymorphism of 1023 Leishmania infantum strains isolated from dogs that have been characterized by multilocus enzyme electrophoresis in the Leishmania Reference Centre of Montpellier, or in other laboratories, to which this typification technique has already been transferred. Between 1981 and 2010, a total of 12 zymodemes were identified around the Mediterranean basin: MON-1, MON-24, MON-34, MON-72, MON-77, MON-80, MON-98, MON-105, MON-108, MON-199, MON-199 var NP1130 and MON-281, of which 6 were present in Algeria. The zymodeme MON-1 was predominant (86.5% of the strains). The dog was confirmed as the main reservoir of L. infantum MON-1, while the reservoir of the other zymodemes has not yet been identified. The enzymatic polymorphism is relatively high in Algeria and in Spain in contrast to other Mediterranean countries. The reasons for this polymorphism are discussed.
authors.affiliation: Ecole Nationale Supérieure Vétérinaire d'Alger, Hacene Badi, El-Harrach, Algiers, Algeria. k.aitoudhia@gmail.com
authors.forename: K
authors.initials: K
authors.lastname: Aït-Oudhia
authors.forename: Z
authors.initials: Z
authors.lastname: Harrat
authors.forename: R
authors.initials: R
authors.lastname: Benikhlef
authors.forename: J P
authors.initials: JP
authors.lastname: Dedet
authors.forename: F
authors.initials: F
authors.lastname: Pratlong
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D004285:Dogs; D004586:Electrophoresis / Q000379:methods; D004798:Enzymes / Q000032:analysis / Q000235:genetics*; D018314:Leishmania infantum / Q000145:classification / Q000201:enzymology* / Q000235:genetics* / Q000302:isolation & purification; D007898:Leishmaniasis, Visceral / Q000469:parasitology / Q000662:veterinary*; D019083:Mediterranean Region; D017720:Molecular Epidemiology; D058889:Molecular Typing; D011110:Polymorphism, Genetic; D015800:Protozoan Proteins / Q000032:analysis / Q000235:genetics*
chemical_list: D004798:Enzymes; D015800:Protozoan Proteins