title: Diverse pathways of oxidative folding of disulfide proteins: underlying causes and folding models.
abstract: The pathway of oxidative folding of disulfide proteins exhibits a high degree of diversity, which is manifested mainly by distinct structural heterogeneity and diverse rearrangement pathways of folding intermediates. During the past two decades, the scope of this diversity has widened through studies of more than 30 disulfide-rich proteins by various laboratories. A more comprehensive landscape of the mechanism of protein oxidative folding has emerged. This review will cover three themes. (1) Elaboration of the scope of diversity of disulfide folding pathways, including the two opposite extreme models, represented by bovine pancreatic trypsin inhibitor (BPTI) and hirudin. (2) Demonstration of experimental evidence accounting for the underlying mechanism of the folding diversity. (3) Discussion of the convergence between the extreme models of oxidative folding and models of conventional conformational folding (framework model, hydrophobic collapse model).
authors.affiliation: Research Center for Protein Chemistry, Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Medical School, The University of Texas, Houston, 77030, USA. Rowen.Chang@uth.tmc.edu
authors.forename: Jui-Yoa
authors.initials: JY
authors.lastname: Chang
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000737:chemistry; D060829:Arthropod Proteins; D004220:Disulfides / Q000737:chemistry*; D006629:Hirudins / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D036341:Intercellular Signaling Peptides and Proteins; D008958:Models, Molecular; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry; D011487:Protein Conformation; D017510:Protein Folding; D011498:Protein Precursors / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*
chemical_list: D060829:Arthropod Proteins; D004220:Disulfides; D006629:Hirudins; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D011498:Protein Precursors; D011506:Proteins; C063967:tick anticoagulant peptide; D007611:Aprotinin