title: Bactericidal capacity of silver nanoparticles associated with Gantrez S-97 on Streptococcus mutans.
abstract: Dental caries is a worldwide public health problem. S mutans plays an important role in the etiology of caries. There have been studies that showed the antimicrobial properties of silver nanoparticles are an effective agent to diminish S. mutans. The objective of this study was to evaluate the bactericidal and bacteriostatic effects of silver nanoparticles in addition to the Gantrez S-27 copolymer, on S mutans.
  
  
  METHODS
  We performed an in vitro experimental study using the liquid microdilution method in order to find the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) with the subcultures obtained. The mixture was obtained by preparing 98 microg/mL of silver nanoparticles (10(3)mol) with Gantrez S-27 2%, in distilled water The readings were performed 24 hours after incubation and on 3 consecutive days. The results showed an average MTC of 6.12 microg /mL and MBC of 6.12 microg /mL.
  
  
  CONCLUSIONS
  The addition of Gantrez 2% to silver nanoparticles does not alter its antimicrobial effect.
authors.affiliation: Clinical Epidemiology Postgraduate Program, Facultad de Medicina, Universidad Autónoma de San Luis Potosi, México.
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Hernández-Sierra
authors.forename: Enid Karina
authors.initials: EK
authors.lastname: Salas-López
authors.forename: Fidel
authors.initials: F
authors.lastname: Martínez-Gutiérrez
authors.forename: Facundo
authors.initials: F
authors.lastname: Ruíz
authors.forename: Mauricio
authors.initials: M
authors.lastname: Pierdant-Pérez
authors.forename: Peter
authors.initials: P
authors.lastname: Mandeville
authors.forename: Amaury J
authors.initials: AJ
authors.lastname: Pozos-Guillén
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008298:Maleates / Q000737:chemistry*; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D018030:Silver Compounds / Q000737:chemistry / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D008298:Maleates; D011145:Polyvinyls; D018030:Silver Compounds; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer