title: Stimuli response of cystamine-core dendrimer revealed by diffusion and NOE NMR studies.
abstract: Stimuli response behaviors of cystamine-core dendrimer in the presence of several reducing agents including vitamin C, sodium bisulfite, and DL-Dithiothreitol are described. A competitive redox cleavage and supramolecular aggregate formation model is proposed based on PFG NMR and (1)H NMR titration experiments. Furthermore, reduction-responsive release of guest molecules from interior pockets of the cystamine-core dendrimer is confirmed by NOE studies. The results suggest that cystamine-core dendrimer is a versatile scaffold or precursor in the design of reduction-sensitive polymeric nanocapsules for biomedical purposes.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui, 230026, People's Republic of China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Feng
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Cheng
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Wu
authors.forename: Jiahai
authors.initials: J
authors.lastname: Zhang
authors.forename: Tongwen
authors.initials: T
authors.lastname: Xu
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry; D003538:Cystamine / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D003840:Deoxycholic Acid / Q000737:chemistry; D004058:Diffusion; D004229:Dithiothreitol / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D053769:Nanocapsules / Q000737:chemistry; D010084:Oxidation-Reduction; D019163:Reducing Agents / Q000737:chemistry; D013447:Sulfites / Q000737:chemistry
chemical_list: D050091:Dendrimers; D053769:Nanocapsules; D019163:Reducing Agents; D013447:Sulfites; D003840:Deoxycholic Acid; D001205:Ascorbic Acid; D003538:Cystamine; D004229:Dithiothreitol; C009279:sodium bisulfite