title: Ameliorative role of atorvastatin on methionine-induced hyperhomocysteinemia and hematological changes in albino rats.
abstract: Methionine (1g/kg, po) administration to pathogenic control rats for 30 days significantly increased the levels of homocysteine, total cholesterol (TC), low density lipoprotein (LDL-C), very low density lipoprotein (VLDL-C) and triglycerides (TGs) and decreased the levels of high density lipoprotein (HDL-C) in serum. Hematological observations of the peripheral blood smears of pathogenic rats fed with methionine also showed crenation of RBCs cell membrane and significant increase in total leukocyte count, differential leukocyte count and platelet counts with significant decrease in the mean hemoglobin levels as compared to vehicle control rats. Administration of atorvastatin (0.2 mg/kg/po) to hyperhomocysteinemic rats significantly decreased the levels of homocysteine, TC, TGs, LDL-C and VLDL-C and increased the levels of HDL-C in serum. The present results provide clear evidence that oral treatment with atorvastatin exhibit homocysteine and lipid lowering activity and also reversal of hematological changes induced by methionine in albino rats.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, India. uma_bora@hotmail.com
authors.forename: Uma
authors.initials: U
authors.lastname: Bhandari
authors.forename: Rahila Ahmad
authors.initials: RA
authors.lastname: Pathan
authors.forename: Vinay
authors.initials: V
authors.lastname: Kumar
authors.forename: Naresh
authors.initials: N
authors.lastname: Khanna
mesh_terms: D000417:Albinism / Q000473:pathology; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000069059:Atorvastatin; D004353:Drug Evaluation, Preclinical; D005260:Female; D006403:Hematologic Tests; D006538:Heptanoic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008715:Methionine; D011758:Pyrroles / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar
chemical_list: D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin; D008715:Methionine