title: Helmholtz-pair transmit coil with integrated receive array for high-resolution MRI of trabecular bone in the distal tibia at 7T.
abstract: A Helmholtz-pair local transmit RF coil with an integrated four-element receive array RF coil and foot immobilization platform was designed and constructed for imaging the distal tibia in a whole-body 7T MRI scanner. Simulations and measurements of the B(1) field distribution of the transmit coil are described, along with SAR considerations for operation at 7T. Results of imaging the trabecular bone of three volunteers at 1.5T, 3T and 7T are presented, using identical 1.5T and 3T versions of the 7T four-element receive array. The spatially registered images reveal improved visibility for individual trabeculae and show average gains in SNR of 2.8× and 4.9× for imaging at 7T compared to 3T and 1.5T, respectively. The results thus display an approximately linear dependence of SNR with field strength and enable the practical utility of 7T scanners for micro-MRI of trabecular bone.
authors.affiliation: Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA. Alexander.Wright@uphs.upenn.edu
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Wright
authors.forename: Rostislav
authors.initials: R
authors.lastname: Lemdiasov
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Connick
authors.forename: Yusuf A
authors.initials: YA
authors.lastname: Bhagat
authors.forename: Jeremy F
authors.initials: JF
authors.lastname: Magland
authors.forename: Hee Kwon
authors.initials: HK
authors.lastname: Song
authors.forename: Steven P
authors.initials: SP
authors.lastname: Toddes
authors.forename: Reinhold
authors.initials: R
authors.lastname: Ludwig
authors.forename: Felix W
authors.initials: FW
authors.lastname: Wehrli
mesh_terms: D000328:Adult; D004867:Equipment Design; D004869:Equipment Safety; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D008297:Male; D010024:Osteoporosis / Q000175:diagnosis; D056888:Patient Positioning; D019047:Phantoms, Imaging; D012016:Reference Values; D013696:Temperature; D013977:Tibia / Q000648:ultrastructure*