title: Nickel-catalyzed selective conversion of two different aldehydes to cross-coupled esters.
abstract: In the presence of a Ni(0)/NHC catalyst, an equimolar mixture of aliphatic and aryl aldehydes can be employed to selectively yield a single cross-coupled ester. This reaction can be applied to a variety of aliphatic (1°, 2°, cyc-2°, and 3°) and aryl aldehyde combinations. The reaction represents 100% atom efficiency and generates no waste. Mechanistic studies have revealed that the striking feature of the reaction is the simultaneous coordination of two aldehydes to Ni(0).
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hoshimoto
authors.forename: Masato
authors.initials: M
authors.lastname: Ohashi
authors.forename: Sensuke
authors.initials: S
authors.lastname: Ogoshi
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D004952:Esters; D009532:Nickel