title: [Introduction of dynamic balancing randomization method and its application].
abstract: Following the development of clinical trials, the methodology of clinical trials has developed a great deal, including randomization method and blinding method, etc. The method of randomization includes simple randomization, stratification randomization, etc. Dynamic randomization is also considered as a method of randomization. Two dynamic randomization methods are introduced in this paper, including a method considering the balance of numbers in each group and a method considering prognostic factors. This paper also demonstrates the procedure of dynamic randomization of the above two methods by simulations and actual examples.
authors.affiliation: Center for Evidence-based Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Zhao-Lan
authors.initials: ZL
authors.lastname: Liu
authors.forename: Bao-Quan
authors.initials: BQ
authors.lastname: Liu
authors.forename: Lan-Hua
authors.initials: LH
authors.lastname: Li
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Liu
mesh_terms: D006801:Humans; D011897:Random Allocation; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design