title: TCF11 at the crossroads of oxidative stress and the ubiquitin proteasome system.
abstract: It is well established that mutual relations exist between the oxidative status of a cell and the ubiquitin proteasome system (UPS). Oxidation of proteins leads to misfolding and thus claims a higher proteolytic activity of the UPS to dispose these proteins. Any disturbance of the proteotoxic-protection machinery may result in protein aggregation and thus in disorders like neurodegenerative diseases or cancer. In this article we describe the molecular mechanisms regulating the ubiquitin proteasome system, thereby focussing on Nrf2 as well as on the recently identified transcription factor (TF) TCF11. In response to proteasome inhibition TCF11 plays a central role in upregulating the proteasome system via an ERAD-dependent feedback loop.
authors.affiliation: Institut für Biochemie, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Annett
authors.initials: A
authors.lastname: Koch
authors.forename: Janos
authors.initials: J
authors.lastname: Steffen
authors.forename: Elke
authors.initials: E
authors.lastname: Krüger
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D051265:NF-E2-Related Factor 1 / Q000235:genetics / Q000378:metabolism; D051267:NF-E2-Related Factor 2 / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D061988:Proteasome Inhibitors; D017510:Protein Folding; D011499:Protein Processing, Post-Translational / Q000235:genetics; D034741:RNA, Small Interfering / Q000378:metabolism; D017382:Reactive Oxygen Species; D015533:Transcriptional Activation; D014407:Tumor Cells, Cultured; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D051265:NF-E2-Related Factor 1; D051267:NF-E2-Related Factor 2; C088357:NFE2L1 protein, human; D061988:Proteasome Inhibitors; D034741:RNA, Small Interfering; D017382:Reactive Oxygen Species; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex