title: Malaria in pregnancy.
abstract: Malaria during pregnancy is a recognised risk factor for maternal and foetal complications and it is endemic in certain areas of our country. Pregnancy also enhances the severity of malaria particularly with P falciparum infestation. The outcome of effects of malaria in pregnancy on the mother and foetus is studied here. This is a prospective observational study conducted in the department of obstetrics and gynaecology of RG Kar Medical College during the period from 1st January 2001 to 31st December 2006. Forty pregnant women with malaria in pregnancy were studied. Another 40 non- pregnant women during the same period were served as control. The maternal complications were compared with the controls and the outcome of pregnancy was studied. There was statistically significant (p < 0.05) increase in the incidence of anaemia, cerebral malaria, renal failure, hepatic failure, hypoglycaemia, hypotension and death in the pregnant women in comparison to non-pregnant women. P falciparum infection was also more during pregnancy. There was also increased incidence of abqrtion, preterm labour, intra-uterine growth restriction and intra-uterine foetal death. Treatment with antimalarial drugs particularly in cerebral malaria does not give good results as there were 12 maternal deaths in this series. Every attempt should be made to prevent malaria during pregnancy by various measures as it is associated with high maternal morbidity and mortality and adversely affects the neonatal outcome.
authors.affiliation: Department of Obstetrics and Gynaecology, RG Kar Medical College, Kolkata 700004.
authors.forename: Subrata Lall
authors.initials: SL
authors.lastname: Seal
authors.forename: Sima
authors.initials: S
authors.lastname: Mukhopadhay
authors.forename: Rajendra Prasad
authors.initials: RP
authors.lastname: Ganguly
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008288:Malaria / Q000150:complications / Q000188:drug therapy / Q000401:mortality / Q000469:parasitology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000401:mortality / Q000469:parasitology; D011256:Pregnancy Outcome; D011446:Prospective Studies
chemical_list: D000962:Antimalarials