title: Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds.
authors.affiliation: Chemistry Research Laboratory, University of Oxford Oxford, OX1 3TA, United Kingdom.
authors.forename: Kai-Hsuan
authors.initials: KH
authors.lastname: Chang
authors.affiliation: Chemistry Research Laboratory, University of Oxford Oxford, OX1 3TA, United Kingdom.
authors.forename: Oliver N F
authors.initials: ONF
authors.lastname: King
authors.affiliation: Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, United Kingdom.
authors.forename: Anthony
authors.initials: A
authors.lastname: Tumber
authors.affiliation: Chemistry Research Laboratory, University of Oxford Oxford, OX1 3TA, United Kingdom.
authors.forename: Esther C Y
authors.initials: ECY
authors.lastname: Woon
authors.affiliation: Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, United Kingdom.
authors.forename: Tom D
authors.initials: TD
authors.lastname: Heightman
authors.affiliation: Chemistry Research Laboratory, University of Oxford Oxford, OX1 3TA, United Kingdom.
authors.forename: Michael A
authors.initials: MA
authors.lastname: McDonough
authors.affiliation: Chemistry Research Laboratory, University of Oxford Oxford, OX1 3TA, United Kingdom.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Schofield
authors.affiliation: Chemistry Research Laboratory, University of Oxford Oxford, OX1 3TA, United Kingdom.
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Rose
mesh_terms: D015082:2,2'-Dipyridyl / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D056484:Jumonji Domain-Containing Histone Demethylases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000737:chemistry; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D007656:Ketoglutaric Acids; D015082:2,2'-Dipyridyl; D056484:Jumonji Domain-Containing Histone Demethylases; C549811:KDM4E protein, human