title: Synthesis and antitumoral activity of gelatin/polyoxometalate hybrid nanoparticles.
abstract: Surfactant-free gelatin/heptamolybdate (HM) hybrid nanoparticles are prepared by a simple and environmentally friendly approach utilizing the electrostatic interaction between anionic HM and the zwitterionic gelatin. The obtained nanoparticles have a tunable size and very high HM loading content up to about 70%. In vitro and in vivo experiments prove that the gelatin/HM hybrid nanoparticles exhibit significantly better antitumor activity than plain ammonium heptamolybdate solution. Therefore, the gelatin/HM hybrid nanoparticles reported here may serve as a prototype platform for polymer/polyoxometalate (POM) hybrid nanoparticles as cancer treatment agents and hence open up more opportunities to maximize the potential of POM-based pharmaceutical agents.
authors.affiliation: Laboratory of Mesoscopic Chemistry, and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Guo
authors.forename: Yuan
authors.initials: Y
authors.lastname: Cheng
authors.forename: Dan
authors.initials: D
authors.lastname: Ding
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Li
authors.forename: Leyang
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiqun
authors.initials: X
authors.lastname: Jiang
authors.forename: Baorui
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000494:pharmacology; D005780:Gelatin / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007279:Injections, Subcutaneous; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D046529:Microscopy, Electron, Transmission; D008982:Molybdenum / Q000737:chemistry / Q000494:pharmacology*; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017973:Tungsten Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000099294:Polyoxometalates
chemical_list: D004337:Drug Carriers; D005780:Gelatin; D008982:Molybdenum; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates; C022175:ammonium molybdate