title: A phosphatidate phosphatase double mutant provides a new insight into plant membrane lipid homeostasis.
abstract: Phospholipids make up the bulk of most eukaryotic cell membranes, but how their synthesis is regulated remains relatively poorly understood in plants. In our article1 we provide evidence that two Mg ( 2+) -dependent phosphatidic acid phosphatase enzymes, called PAH1 and PAH2, are capable of repressing phospholipid biosynthesis at the endoplasmic reticulum in Arabidopsis thaliana. The precise mechanism of repression remains unclear and it does appear to vary in several respects from that already described in Saccharomyces cerevisiae. ( 2,3).
authors.affiliation: University of Warwick, School of Life Sciences, Warwickshire, UK. p.j.eastmond@warwick.ac.uk
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Eastmond
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Quettier
authors.forename: Johan T
authors.initials: JT
authors.lastname: Kroon
authors.forename: Christian
authors.initials: C
authors.lastname: Craddock
authors.forename: Nicolette
authors.initials: N
authors.lastname: Adams
authors.forename: Antoni R
authors.initials: AR
authors.lastname: Slabas
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D009154:Mutation; D010711:Phosphatidate Phosphatase / Q000235:genetics / Q000378:metabolism*; D030821:Plants, Genetically Modified / Q000235:genetics / Q000378:metabolism
chemical_list: D008563:Membrane Lipids; D010711:Phosphatidate Phosphatase