title: Two-dimensional linear-combination model fitting of magnetic resonance spectra to define the macromolecule baseline using FiTAID, a Fitting Tool for Arrays of Interrelated Datasets.
abstract: OBJECTIVE
  To propose the determination of the macromolecular baseline (MMBL) in clinical 1H MR spectra based on T(1) and T(2) differentiation using 2D fitting in FiTAID, a general Fitting Tool for Arrays of Interrelated Datasets.
  
  
  METHODS
  Series of localized inversion-recovery (IR) and 2DJ separation spectra of the brain were recorded at 3T. The MMBL was determined by three 2D evaluation methods based on (1) IR spectra only, (2) 2DJ spectra only, (3) both IR and 2DJ spectra (2DJ-IR). Their performance was compared using synthetic spectra and based on variability and reproducibility as obtained in vivo from 12 subjects in 20 examinations.
  
  
  RESULTS
  All methods performed well for synthetic data. In vivo, 2DJ-only yielded larger variations than the other methods. IR-only and 2DJ-IR yielded similar performance. FiTAID is illustrated with further applications where linear-combination model fitting of interrelated arrays of spectra is advantageous.
  
  
  CONCLUSIONS
  2D-Fitting offers the possibility to determine the MMBL based on a range of complementary experimental spectra not relying on smoothness criteria or global assumptions on T(1). Since 2DJ-IR includes information from spectra with different inversion and echo times, it is expected to be more robust in cases with more variable data quality and overlap with lipid resonances.
authors.affiliation: Department of Clinical Research, Unit for MR-Spectroscopy and Methodology, University Bern, Inselspital, P.O. Box 35, 3010, Bern, Switzerland.
authors.forename: Daniel G Q
authors.initials: DG
authors.lastname: Chong
authors.forename: Roland
authors.initials: R
authors.lastname: Kreis
authors.forename: Christine S
authors.initials: CS
authors.lastname: Bolliger
authors.forename: Chris
authors.initials: C
authors.lastname: Boesch
authors.forename: Johannes
authors.initials: J
authors.lastname: Slotboom
mesh_terms: D000465:Algorithms; D006801:Humans; D007256:Information Systems; D016014:Linear Models; D046911:Macromolecular Substances / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D008956:Models, Chemical; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*
chemical_list: D046911:Macromolecular Substances