title: Resolution of severe obsessive--compulsive disorder after a small unilateral nondominant frontoparietal infarct.
abstract: Obsessive--compulsive disorder (OCD) is a disabling neuropsychiatric disorder, which rarely spontaneously remits. We present a case of a patient suffering with severe OCD whose symptoms disappeared immediately following a small right posterior frontoparietal infarct. We speculate that the lesion modulated the cortical-subcortical circuits, likely through a change in input into in the dorsolateral prefrontal cortex. This could have implications regarding surgical targeting in OCD.
authors.affiliation: Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: A
authors.initials: A
authors.lastname: Diamond
authors.forename: W G
authors.initials: WG
authors.lastname: Ondo
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D001921:Brain / Q000473:pathology; D016642:Bupropion / Q000627:therapeutic use; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000150:complications / Q000473:pathology / Q000523:psychology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D018908:Muscle Weakness / Q000209:etiology; D009415:Nerve Net / Q000473:pathology; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000523:psychology*; D010292:Paresthesia / Q000209:etiology; D010296:Parietal Lobe / Q000473:pathology
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion