title: The prevalence of dementia and depression in Taiwanese institutionalized leprosy patients, and the effectiveness evaluation of reminiscence therapy--a longitudinal, single-blind, randomized control study.
abstract: OBJECTIVE
  This study investigated the prevalence of depression and dementia in long-term institutionalized older leprosy patients in Taiwan. We then examined the effectiveness of reminiscence group therapy on depressive symptoms and cognitive function in this population.
  
  
  METHODS
  We recruited 129 long-term institutionalized older leprosy patients in Taiwan and used the Geriatric Depression Scale-Short Form (GDS-SF), the mini mental state examination (MMSE), and the Clinical Dementia Rating (CDR) scale for outcome measurement. We then conducted a single-blind, randomized, longitudinal quasi-experimental analysis comparing the pre-test and post-test results of two equivalent groups at a 24-week intervention interval. The intervention in the experimental group was three sessions of reminiscence group therapy per week, whereas that in the control group was weekly individual supportive interviews.
  
  
  RESULTS
  The prevalence of dementia was 45.7-50.4% according to a CDR score ≥ 0.5 and an MMSE score < 25, and the prevalence of depression was 25% based on a GDS-SF score ≥ 7. According to the Wilcoxon signed-rank test, the GDS-SF scores in the experimental group decreased significantly (p = 0.02) after intervention as compared with that in the control group (p = 0.22), whereas the MMSE scores in both groups remained steady.
  
  
  CONCLUSIONS
  The prevalence of dementia and depression in long-term institutionalized older leprosy patients in Taiwan is high. Reminiscence group therapy has been confirmed effective on depression in this population, but its effectiveness on cognitive function requires further verification.
authors.affiliation: Department of Psychiatry, Losheng Sanatorium Hospital, Department of Health, Taiwan.
authors.forename: Tsung-Wei
authors.initials: TW
authors.lastname: Su
authors.forename: Li-Ling
authors.initials: LL
authors.lastname: Wu
authors.forename: Ching-Po
authors.initials: CP
authors.lastname: Lin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D010054:Brief Psychiatric Rating Scale; D003072:Cognition Disorders / Q000523:psychology / Q000628:therapy; D003704:Dementia / Q000453:epidemiology* / Q000628:therapy*; D003866:Depressive Disorder / Q000453:epidemiology* / Q000628:therapy*; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006801:Humans; D007326:Institutionalization / Q000706:statistics & numerical data*; D007918:Leprosy / Q000523:psychology*; D008137:Longitudinal Studies; D008297:Male; D011939:Mental Recall; D015995:Prevalence; D011615:Psychotherapy, Group / Q000379:methods*; D016037:Single-Blind Method; D013624:Taiwan / Q000453:epidemiology