title: Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options.
abstract: Mast cell activation disease comprises disorders characterized by accumulation of genetically altered mast cells and/or abnormal release of these cells' mediators, affecting functions in potentially every organ system, often without causing abnormalities in routine laboratory or radiologic testing. In most cases of mast cell activation disease, diagnosis is possible by relatively non-invasive investigation. Effective therapy often consists simply of antihistamines and mast cell membrane-stabilising compounds supplemented with medications targeted at specific symptoms and complications. Mast cell activation disease is now appreciated to likely be considerably prevalent and thus should be considered routinely in the differential diagnosis of patients with chronic multisystem polymorbidity or patients in whom a definitively diagnosed major illness does not well account for the entirety of the patient's presentation.
authors.affiliation: Institute of Human Genetics, University Hospital of Bonn, Germany. molderings@uni-bonn.de
authors.forename: Gerhard J
authors.initials: GJ
authors.lastname: Molderings
authors.forename: Stefan
authors.initials: S
authors.lastname: Brettner
authors.forename: Jürgen
authors.initials: J
authors.lastname: Homann
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Afrin
mesh_terms: D000818:Animals; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D008407:Mast Cells / Q000187:drug effects / Q000473:pathology*; D008415:Mastocytosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology
chemical_list: D006633:Histamine Antagonists