title: [The clinical features of infection in multiple myeloma undergoing autologous hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To explore the clinical features of infection in multiple myeloma (MM) undergoing autologous hematopoietic stem cell transplantation (ASCT).
  
  
  METHODS
  Thirty-seven patients with MM undergoing ASCT were retrospectively analyzed for type and time of infection, pathogen, and outcome.
  
  
  RESULTS
  Fifty-nine cases of infectious complications occurred in 33 patients (89.2%) after ASCT, with 34 cases (57.6%) of bacterial infections in 30 patients, 15 cases (25.4%) of fungal infections in 12 patients, 4 cases (6.8%) of cytomegalovirus (CMV) infection, 3 cases (5.1%) of herpes zoster virus infection and 3 cases (5.1%) of HBV reactivation. The proportion of bacterial infection, fungal infection and virus infection were 62.8%, 28.6% and 8.6% respectively in the early stage after ASCT, and 50.0%, 20.8% and 29.3% respectively in the median stage. Response to first-line antibiotic therapy was seen in 38 cases (64.4%). Infection-related mortality was 8.1% (3 cases).
  
  
  CONCLUSIONS
  The incidence of infection in MM patients undergoing ASCT is high and they are susceptible to all pathogens. It is important to choose the right antifungal agents as quickly as possible to reduce infection-related mortality.
authors.affiliation: Department of Hematology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. luliyuan@tom.com
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Bei-hui
authors.initials: BH
authors.lastname: Huang
authors.forename: Zhen-hai
authors.initials: ZH
authors.lastname: Zhou
authors.forename: Dong
authors.initials: D
authors.lastname: Zheng
authors.forename: Duo-rong
authors.initials: DR
authors.lastname: Xu
authors.forename: Wai-yi
authors.initials: WY
authors.lastname: Zou
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D007239:Infections / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000382:microbiology / Q000601:surgery*; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D016896:Treatment Outcome