title: Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients.
abstract: OBJECTIVE
  The purpose of this study is to examine the association of HLA-B*1502 allele with CBZ-induced SJS/TEN in the mainland Han Chinese population.
  
  
  METHODS
  HLA-B*1502 genotyping with sequence-specific primer polymerase chain reaction (PCR-SSP) and PCR-sequencing based typing (PCR-SBT) was performed on 17 CBZ-induced SJS/TEN patients, 21 CBZ-tolerant controls, and 185 healthy controls recruited during 2008-2010.
  
  
  RESULTS
  HLA-B*1502 allele was present in 94.1% (16/17) of CBZ-SJS/TEN patients, 9.5% (2/21) of CBZ-tolerant patients, and 9.2% (17/185) of healthy controls. The risk of CBZ-induced SJS/TEN was significantly higher (P < 0.01) in the patients with HLA-B*1502. One CBZ-induced SJS patient tested negative for HLA-B*1502, and the test result showed HLA-B*3503/B*4601.
  
  
  CONCLUSIONS
  We found a strong association between HLA-B*1502 and CBZ-induced SJS/TEN in the Han Chinese population from central and northern China. Combined with previous studies of the southern Han Chinese subpopulation, our results suggest that HLA-B*1502 is strongly associated with CBZ-induced SJS/TEN in the whole Han Chinese population.
authors.affiliation: Department of Clinical Pharmacology Research Lab, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Shen
authors.forename: Ling
authors.initials: L
authors.lastname: Xue
authors.forename: Xiao-Xian
authors.initials: XX
authors.lastname: Zheng
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: He
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Gong
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Miao
mesh_terms: D000328:Adult; D000483:Alleles; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059910:HLA-B15 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000208:ethnology / Q000209:etiology / Q000235:genetics*
chemical_list: D000927:Anticonvulsants; C483536:HLA-B*15:02 antigen; D059910:HLA-B15 Antigen; D002220:Carbamazepine