title: Risk factors for intrahepatic recurrence after curative surgical treatment of colorectal liver metastases.
abstract: OBJECTIVE
  Hepatic resection has been regarded as the only curative treatment for colorectal liver metastases. After a first hepatectomy, 30% to 70% of patients develop intrahepatic recurrence. In this study, we retrospectively analyzed risk factors for intrahepatic recurrence.
  
  
  METHODS
  From April 1990 to December 2006, 86 patients with colorectal liver metastases underwent curative hepatic resection at Kanagawa Cancer Center. Clinicopathological characteristics of 35 patients in the intrahepatic recurrence group were compared with those of 30 patients in the no recurrence group.
  
  
  RESULTS
  The 5-year survival rate was 18.7% for patients in the intrahepatic recurrence group. Lymph node metastases of primary colorectal cancer and synchronous liver metastases were found to be independently associated with intrahepatic recurrence.
  
  
  CONCLUSIONS
  We suggest that neoadjuvant chemotherapy before hepatectomy should be considered as feasible treatment for reducing intrahepatic recurrence in two cases; One case is resectable synchronous liver metastases from colorectal cancer, and the other is resectable metachronous liver metastases with primary regional lymph node metastases from colorectal cancer.
authors.affiliation: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama 241-0815, Japan. amanex2009@gmail.com
authors.forename: Amane
authors.initials: A
authors.lastname: Kanazawa
authors.forename: Manabu
authors.initials: M
authors.lastname: Shiozawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Inagaki
authors.forename: Soichiro
authors.initials: S
authors.lastname: Morinaga
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sugimasa
authors.forename: Takashi
authors.initials: T
authors.lastname: Oshima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada
authors.forename: Makoto
authors.initials: M
authors.lastname: Akaike
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D012307:Risk Factors