title: Clinical trial structures.
abstract: Most errors in clinical trials are a result of poor planning. Fancy statistical methods cannot rescue design flaws. Thus careful planning with clear foresight is crucial. The selection of a clinical trial design structure requires logic and creativity. Common structural designs are discussed.
authors.affiliation: Department of Statistics, Harvard University, Boston, MA.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Evans