title: Increased serum levels of oxidative stress are associated with hospital readmissions due to acute heart failure.
abstract: OBJECTIVE
  Inflammation and serum oxidative stress (OS) are important components in heart failure (HF) deterioration. In this study we tested the hypothesis that an increase in patients' sera OS levels is associated with acute HF (AHF) readmissions.
  
  
  METHODS
  Thirty consecutive patients (mean age 71 ± 10 years) admitted with AHF were included in the study. Serum OS in these patients was measured in-hospital and repeatedly after discharge over a period of 8 weeks of follow-up in which we reordered patients' HF readmissions. Of the 30 patients, 13 (43%) were readmitted (RAD group) and 17 (57%) did not require readmission (NRAD group).
  
  
  RESULTS
  OS levels before discharge from the first hospital admission in the 2 groups were similar (p = 0.84 and p = 0.56, respectively). However, using repeated measures ANOVA, we found that the interaction between the time points and the 2 groups of patients (RAD and NRAD) was statistically significant (p = 0.037). It is important to note that OS serum levels were more predictive of HF readmissions than were repeated simultaneous serum measurements of NT-proBNP (p = 0.97).
  
  
  CONCLUSIONS
  Increased OS levels in AHF patients, after they have been discharged from the hospital, are associated with higher HF readmission rates. In AHF, OS is a dynamic parameter associated with HF deterioration.
authors.affiliation: Department of Internal Medicine E, Tel Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ori
authors.initials: O
authors.lastname: Rogowski
authors.forename: Sergei
authors.initials: S
authors.lastname: Shnizer
authors.forename: Rafael
authors.initials: R
authors.lastname: Wolff
authors.forename: Basil S
authors.initials: BS
authors.lastname: Lewis
authors.forename: Offer
authors.initials: O
authors.lastname: Amir
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010359:Patient Readmission / Q000706:statistics & numerical data*; D012008:Recurrence