title: Temporal modulation of spike-timing-dependent plasticity.
abstract: Spike-timing-dependent plasticity (STDP) has attracted considerable experimental and theoretical attention over the last decade. In the most basic formulation, STDP provides a fundamental unit - a spike pair - for quantifying the induction of long-term changes in synaptic strength. However, many factors, both pre- and postsynaptic, can affect synaptic transmission and integration, especially when multiple spikes are considered. Here we review the experimental evidence for multiple types of nonlinear temporal interactions in STDP, focusing on the contributions of individual spike pairs, overall spike rate, and precise spike timing for modification of cortical and hippocampal excitatory synapses. We discuss the underlying processes that determine the specific learning rules at different synapses, such as postsynaptic excitability and short-term depression. Finally, we describe the success of efforts toward building predictive, quantitative models of how complex and natural spike trains induce long-term synaptic modifications.
authors.affiliation: Molecular Neurobiology Program, Departments of Otolaryngology and Physiology/Neuroscience, The Helen and Martin Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine New York, NY, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Froemke
authors.forename: Dominique
authors.initials: D
authors.lastname: Debanne
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Bi