title: [Familial benign chronic pemphigus (Hailey-Hailey disease): successful treatment with carbon dioxide laser].
abstract: Hailey-Hailey disease is a rare, autosomal dominantly inherited genodermatosis, which manifests with recurrent intraepidermal blistering and erythematous hyperkeratotic patches in intertriginous areas. Conventional therapeutic approaches include topical and systemic steroids, antibiotic agents, as well as oral retinoids. Alternative treatments include surgical interventions such as excision, dermabrasion and laser ablation. A 56-year-old woman presented with 15-year history of severe therapy-resistant Hailey-Hailey disease. We performed laser ablation with carbon dioxide laser under general anesthesia. Six weeks after treatment complete remission within ablated areas was achieved. Six-month follow-up showed no relapse. In our opinion carbon dioxide laser ablation represents an effective and safe therapeutic option for Hailey-Hailey disease.
authors.affiliation: Hautklinik des Universitätsklinikums Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Deutschland.
authors.forename: G
authors.initials: G
authors.lastname: Kukova
authors.forename: B
authors.initials: B
authors.lastname: Homey
authors.forename: D
authors.initials: D
authors.lastname: Bruch-Gerharz
authors.forename: E
authors.initials: E
authors.lastname: Diedrichson
mesh_terms: D005260:Female; D006801:Humans; D054020:Lasers, Gas; D028022:Low-Level Light Therapy / Q000379:methods*; D008875:Middle Aged; D016506:Pemphigus, Benign Familial / Q000473:pathology* / Q000532:radiotherapy*; D016896:Treatment Outcome