title: Association between cognitive function and plasma lipids of the elderly after controlling for apolipoprotein E genotype.
abstract: OBJECTIVE
  Although the relationship between cognitive function and plasma lipids has attracted attention, previous studies have shown conflicting results. One possible confounding factor is due to the influence of gene-related modulator. We investigated the relationship between cognitive function and lipid plasma levels of old age after controlling for apolipoprotein E (APOE) genotype.
  
  
  METHODS
  One thousand three hundred ninety-five subjects without dementia age 65 and older participated in this study. They were divided into two groups, with and without APOE4 [E4 (+) and E4 (-)]. Plasma concentrations of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC) and apolipoprotein E (apoE) were measured. Associations between plasma concentrations of lipids and cognitive function were investigated for each group.
  
  
  RESULTS
  We found a positive association between cognitive scores and plasma apoE level in both E4 (-) and E4 (+) groups. A positive relationship was also observed between cognitive score and HDL level in the E4 (-) group, but not in the E4 (+) group. No substantial association between cognitive score and LDL, TG, and TC levels was found in either of the groups.
  
  
  CONCLUSIONS
  Our findings suggest that plasma apoE have a positive influence on cognitive function in both E4 (-) and E4 (+) groups, whereas the positive influence of plasma HDL was shown only in E4 (-) group. The identification of the influences of (APOE) genotype and the intracellular linkage among apoE and HDL metabolism is hoped for new preventive and therapeutic strategies for cognitive change of elderly.
authors.affiliation: Department of Neuropsychiatry, National Cerebral and Cardiovascular Center, Osaka, Japan. yasunof@hsp.ncvc.go.jp
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yasuno
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanimukai
authors.forename: Megumi
authors.initials: M
authors.lastname: Sasaki
authors.forename: Shin
authors.initials: S
authors.lastname: Hidaka
authors.forename: Chiaki
authors.initials: C
authors.lastname: Ikejima
authors.forename: Fumio
authors.initials: F
authors.lastname: Yamashita
authors.forename: Chiine
authors.initials: C
authors.lastname: Kodama
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Mizukami
authors.forename: Makoto
authors.initials: M
authors.lastname: Michikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Asada
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood / Q000235:genetics / Q000523:psychology*; D053327:Apolipoprotein E4 / Q000235:genetics*; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D002784:Cholesterol / Q000097:blood / Q000235:genetics*; D003071:Cognition / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000235:genetics*; D008297:Male; D009483:Neuropsychological Tests; D014280:Triglycerides / Q000097:blood / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol