title: Studying synergism of methyl linked cyclohexyl thiophenes with triazole: synthesis and their cdk5/p25 inhibition activity.
abstract: A novel clubbed triazolyl thiophene series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease.
authors.affiliation: Dr. Reddy's Laboratories, Ameerpet, Hyderabad, India.
authors.forename: Mahendra
authors.initials: M
authors.lastname: Shiradkar
authors.forename: John
authors.initials: J
authors.lastname: Thomas
authors.forename: Vanita
authors.initials: V
authors.lastname: Kanase
authors.forename: Rajendra
authors.initials: R
authors.lastname: Dighe
mesh_terms: D051360:Cyclin-Dependent Kinase 5 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004357:Drug Synergism; D006801:Humans; D015394:Molecular Structure; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D009419:Nerve Tissue Proteins; C118136:TPPP protein, human; D013876:Thiophenes; D014230:Triazoles; D051360:Cyclin-Dependent Kinase 5