title: Lipid nanocapsules loaded with rhenium-188 reduce tumor progression in a rat hepatocellular carcinoma model.
abstract: BACKGROUND
  Due to their nanometric scale (50 nm) along with their biomimetic properties, lipid nanocapsules loaded with Rhenium-188 (LNC(188)Re-SSS) constitute a promising radiopharmaceutical carrier for hepatocellular carcinoma treatment as its size may improve tumor penetration in comparison with microspheres devices. This study was conducted to confirm the feasibility and to assess the efficacy of internal radiation with LNC(188)Re-SSS in a chemically induced hepatocellular carcinoma rat model.
  
  
  RESULTS
  Animals were treated with an injection of LNC(188)Re-SSS (80 MBq or 120 MBq). The treated animals (80 MBq, n = 12; 120 MBq, n = 11) were compared with sham (n = 12), blank LNC (n = 7) and (188)Re-perrhenate (n = 4) animals. The evaluation criteria included rat survival, tumor volume assessment, and vascular endothelial growth factor quantification. Following treatment with LNC(188)Re-SSS (80 MBq) therapeutic efficiency was demonstrated by an increase in the median survival from 54 to 107% compared with control groups with up to 7 long-term survivors in the LNC(188)Re-SSS group. Decreased vascular endothelial growth factor expression in the treated rats could indicate alterations in the angiogenesis process.
  
  
  CONCLUSIONS
  Overall, these results demonstrate that internal radiation with LNC(188)Re-SSS is a promising new strategy for hepatocellular carcinoma treatment.
authors.affiliation: LUNAM Université, Université d'Angers, INSERM U646, Angers, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Vanpouille-Box
authors.forename: Franck
authors.initials: F
authors.lastname: Lacoeuille
authors.forename: Jérôme
authors.initials: J
authors.lastname: Roux
authors.forename: Christophe
authors.initials: C
authors.lastname: Aubé
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Garcion
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lepareur
authors.forename: Frédéric
authors.initials: F
authors.lastname: Oberti
authors.forename: Francis
authors.initials: F
authors.lastname: Bouchet
authors.forename: Nicolas
authors.initials: N
authors.lastname: Noiret
authors.forename: Etienne
authors.initials: E
authors.lastname: Garin
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Benoît
authors.forename: Olivier
authors.initials: O
authors.lastname: Couturier
authors.forename: François
authors.initials: F
authors.lastname: Hindré
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000201:enzymology / Q000473:pathology*; D002404:Catheterization; D004195:Disease Models, Animal; D018450:Disease Progression; D007700:Kinetics; D008055:Lipids / Q000737:chemistry* / Q000493:pharmacokinetics; D008113:Liver Neoplasms / Q000097:blood / Q000201:enzymology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D053769:Nanocapsules / Q000737:chemistry*; D011868:Radioisotopes; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000737:chemistry* / Q000493:pharmacokinetics; D016019:Survival Analysis; D014018:Tissue Distribution; D000637:Transaminases / Q000378:metabolism; D047368:Tumor Burden; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D008055:Lipids; D053769:Nanocapsules; D011868:Radioisotopes; D042461:Vascular Endothelial Growth Factor A; D012211:Rhenium; D000637:Transaminases