title: Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention.
abstract: The concept of peptides as therapeutic agents has been historically disregarded by the pharmaceutical industry on account of their susceptibility to degradation, their size and consequent limitations in methods of delivery. Recently, however, there has been a surge of interest in peptides and their mimetics as potential antagonists for therapeutic intervention. This is in part due to the increased half-life and oral availability that has been achieved for a number of peptide-based systems, the introduction and acceptance of alternative delivery methods, and the prevalence of proteomics to identify countless protein-protein interaction targets. The use of peptides and molecules that mimic their function therefore has great potential to effectively target a range of proteins that are pathogenically implicated in numerous diseases.
authors.affiliation: Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK. jmason@essex.ac.uk
authors.forename: Jody M
authors.initials: JM
authors.lastname: Mason
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry* / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans; D010455:Peptides / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D010455:Peptides