title: Antimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms.
abstract: The resistance of biofilms to conventional antibiotics complicates the treatment of chronic cystic fibrosis (CF). We investigated the effects of peptoids, peptides, and conventional antibiotics on the biomass and cell viability within Pseudomonas aeruginosa biofilms. At their MICs, peptoids 1 and 1-C13(4mer) caused maximum reductions in biomass and cell viability, respectively. These results suggest that peptoids of this class could be worth exploring for the treatment of pulmonary infections occurring in CF patients.
authors.affiliation: Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
authors.forename: Rinki
authors.initials: R
authors.lastname: Kapoor
authors.forename: Mayken W
authors.initials: MW
authors.lastname: Wadman
authors.forename: Michelle T
authors.initials: MT
authors.lastname: Dohm
authors.forename: Ann M
authors.initials: AM
authors.lastname: Czyzewski
authors.forename: Alfred M
authors.initials: AM
authors.lastname: Spormann
authors.forename: Annelise E
authors.initials: AE
authors.lastname: Barron
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D003550:Cystic Fibrosis / Q000150:complications; D006801:Humans; D008969:Molecular Sequence Data; D034444:Peptoids / Q000494:pharmacology*; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D034444:Peptoids