title: Comparison of the memory performance index with standard neuropsychological measures of cognition.
abstract: The Mild Cognitive Impairment Screen (MCIS) is a computer-based cognitive assessment designed for clinical and research use in detecting amnestic mild cognitive impairment (aMCI). Performance on the MCIS is reported as the Memory Performance Index (MPI). However, the comparability between the MPI and traditional neuropsychological tests in detecting aMCI, and in differentiating it from Alzheimer's disease (AD) and normal aging has not been examined. A cross-sectional study was conducted to assess the validity of the MPI relative to standard neuropsychological measures. Participants included 12 individuals diagnosed with aMCI, 49 with mild AD, and 25 healthy elderly. The MCIS significantly discriminated among aMCI, AD, and healthy elderly controls. The MCIS is effective in detecting aMCI, and in discriminating it from cognitive changes observed in AD and normal aging. The MCIS may be a valuable tool in the identification of elderly at high risk for dementia due to its ease-of-use and brief administration time.
authors.affiliation: Shiley-Marcos Alzheimer's Disease Research Center and the Department of Neurosciences, University of California, San Diego, CA, USA. mrafii@ucsd.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Rafii
authors.forename: Curtis
authors.initials: C
authors.lastname: Taylor
authors.forename: Alice
authors.initials: A
authors.lastname: Coutinho
authors.forename: Ken
authors.initials: K
authors.lastname: Kim
authors.forename: Douglas
authors.initials: D
authors.lastname: Galasko
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D002140:California; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D003430:Cross-Sectional Studies; D003936:Diagnosis, Computer-Assisted / Q000706:statistics & numerical data*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D008569:Memory Disorders / Q000175:diagnosis* / Q000523:psychology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011594:Psychometrics / Q000706:statistics & numerical data; D012372:ROC Curve; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity