title: [Effect of zuojin pill and fanzuojin pill on the growth metabolism of enterobacteria by microcalorimetry].
abstract: OBJECTIVE
  To study the effects of Zuojin Pill and Fanzuojin Pill (ZJP and FZJP) on the growth metabolism of enterobacteria from the biothermodynamic viewpoint, and to objectively validate the difference between the two drugs for investigating a new way in congener Chinese drugs research.
  
  
  METHODS
  The growth metabolism power-time curves of enterobacteria affected by ZJP and FZJP in different concentrations were obtained by microcalorimetry. And the activities of the two drugs were assessed depending some related characteristic parameters, including growth rate constant (k), maximum output power (P(max)), peak time (T(p)) , maximum heat-output (Q1), and bacteria inhibition rate (I).
  
  
  RESULTS
  With the drugs' concentration increasing, T(p) was prolonged, k value reduced in enterobacteria, i.e. , the two drugs both inhibited the growth of enterobacteria in different extents. Comparison of inhibiting rates showed that the bacteriostasis activity of ZJP was greater than that of FZJP.
  
  
  CONCLUSIONS
  There was objective difference in activities of inhibiting enterobacteria between ZJP and FZJP. Microcalorimetry could express the features at real-time, on-line and sensitively. It was able to determine the activity of drugs accurately and quickly in appraising congener Chinese drugs, like ZJP and FZJP, by microcalorimetry.
authors.affiliation: China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing.
authors.forename: Dan-Hong
authors.initials: DH
authors.lastname: Cheng
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zhao
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Yang
mesh_terms: D000818:Animals; D002151:Calorimetry; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D004365:Drugs, Chinese Herbal; C545320:zuojin