title: Association of diabetes mellitus with myocardial collagen accumulation and relaxation impairment in patients with dilated cardiomyopathy.
abstract: OBJECTIVE
  To assess the effects of diabetes mellitus (DM) on myocardial collagen accumulation, myocardial relaxation, and prognosis in patients with dilated cardiomyopathy (DCM).
  
  
  METHODS
  A total of 102 consecutive DCM patients with a New York Heart Association functional class of I or II were enrolled. Patients were allocated to two groups on the basis of the presence (DCM+DM group, n = 30) or absence (DCM-DM group, n = 72) of DM. Cardiac catheterization performed and left ventricular pressure were measured in all patients. The pressure half-time (T(1/2)) was determined as an index of myocardial relaxation function. Endomyocardial specimens were subjected to histological analysis.
  
  
  RESULTS
  The T(1/2) was significantly longer (P < 0.001) and the collagen volume fraction was significantly greater (P = 0.018) in the DCM + DM group than in the DCM-DM group. Multivariate analysis showed that DM was significantly associated with increased incidence of cardiac events (hazard ratio, 3.7; 95% confidence interval, 1.05 to 13.16; P = 0.03).
  
  
  CONCLUSIONS
  The prognosis of DCM patients with DM was worse than that of those without DM. Impairment of myocardial relaxation, increased myocardial fibrosis, and mitochondrial degeneration associated with DM may underlie this difference.
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya 466-8550, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Sakakibara
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hirashiki
authors.forename: Xian Wu
authors.initials: XW
authors.lastname: Cheng
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Bando
authors.forename: Kei
authors.initials: K
authors.lastname: Ohshima
authors.forename: Takahiro
authors.initials: T
authors.lastname: Okumura
authors.forename: Hidehito
authors.initials: H
authors.lastname: Funahashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Ohshima
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
mesh_terms: D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000378:metabolism* / Q000503:physiopathology*; D003094:Collagen / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*
chemical_list: D003094:Collagen