title: Synthesis, characterization and biological properties of cobalt(II) complexes of 1,10-phenanthroline and maltol.
abstract: The synthesis and characterization of two cobalt(II) complexes, Co(phen)(ma)Cl 1 and Co(ma)(2)(phen) 2, (phen=1,10-phenanthroline, ma(-)=maltolate or 2-methyl-4-oxo-4H-pyran-3-olate) are reported herein. The complexes have been characterized by FTIR, CHN analysis, fluorescence spectroscopy, UV-visible spectroscopy, conductivity measurement and X-ray crystallography. The number of chelated maltolate ligands seems to influence their DNA recognition, topoisomerase I inhibition and antiproliferative properties.
authors.affiliation: Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Kuala Lumpur, Malaysia.
authors.forename: Lee Fang
authors.initials: LF
authors.lastname: Chin
authors.forename: Siew Ming
authors.initials: SM
authors.lastname: Kong
authors.forename: Hoi Ling
authors.initials: HL
authors.lastname: Seng
authors.forename: Kong Soo
authors.initials: KS
authors.lastname: Khoo
authors.forename: Rajamurthy
authors.initials: R
authors.lastname: Vikneswaran
authors.forename: Siang Guan
authors.initials: SG
authors.lastname: Teoh
authors.forename: Munirah
authors.initials: M
authors.lastname: Ahmad
authors.forename: Soo Beng Alan
authors.initials: SB
authors.lastname: Khoo
authors.forename: Mohd Jamil
authors.initials: MJ
authors.lastname: Maah
authors.forename: Chew Hee
authors.initials: CH
authors.lastname: Ng
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003035:Cobalt / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010618:Phenanthrolines / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D002614:Chelating Agents; D008024:Ligands; D009942:Organometallic Compounds; D010618:Phenanthrolines; D011753:Pyrones; C008316:maltol; D003035:Cobalt; D004247:DNA; D004264:DNA Topoisomerases, Type I; C025205:1,10-phenanthroline