title: [Study of cytochrome P450 1A1 gene 3'-UTR 6235T-C polymorphism and susceptibility to breast cancer with Uighur medicine].
abstract: OBJECTIVE
  To explore the association between polymorphism of cytochrome P450 1A1 Gene 3'-UTR (3'-untranslated region) 6235T-C and breast cancer with abnormal Hilit in Chinese Han population of Xinjiang.
  
  
  METHODS
  The breast cancer patients were divided into four body fluids according to Uighur medical theories. And the technique of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed to detect the genotypic and allelic frequencies of 6235T-C polymorphism situated in 3'-untranslated region of CYP1A1 gene in 137 breast cancer patients with abnormal Hilit and 148 normal control subjects in Han population of Xinjiang province.
  
  
  RESULTS
  (1) Significant differences in the genotypic and allelic distribution frequencies of CYP1A1 gene 3'-UTR6235T-C were found between breast cancer patients with abnormal Sapra Hilit and controls (χ(2) = 8.790, P = 0.012; χ(2) = 7.102, P = 0.008). The frequencies of CC genotype and C allele were significantly higher in breast cancer patients with abnormal Sapra Hilit (16.4% vs 39.8%) than in controls (4.7% vs 25.7%). (2) Significant differences in the genotypes and allelic distribution frequencies of CYP1A1 gene 3'-UTR6235T-C were found between breast cancer patients with abnormal Savda Hilit and controls (χ(2) = 6.638, P = 0.036; χ(2) = 5.824, P = 0.016). And the frequencies of TC, CC genotypes and C allele were significantly higher in breast cancer patients with abnormal Savda Hilit (56.9%, 9.8%, 39.2%) than those of the controls (41.9%, 4.7%, 25.7%).
  
  
  CONCLUSIONS
  The CC genotype and C allele of 6235T-C polymorphism of CYP1A1 may be linked with breast cancer with abnormal Sapra Hilit and abnormal savda Hilit in Chinese Han population of Xinjiang province. But they are not correlated with the susceptibility to breast cancer with abnormal Balgham Hilit.
authors.affiliation: College of Life Sciences and Technology, Xinjiang University, Urumqi 830046, China.
authors.forename: Maimaiti
authors.initials: M
authors.lastname: Tuerxun
authors.forename: Wupuer
authors.initials: W
authors.lastname: Hamulati
authors.forename: Lan
authors.initials: L
authors.lastname: Bai
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Peng
authors.forename: Mamatyusupu
authors.initials: M
authors.lastname: Dolikun
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D019363:Cytochrome P-450 CYP1A1