title: Electrochemiluminescence of tris(2,2'-bipyridyl)ruthenium and its applications in bioanalysis: a review.
abstract: Electrochemiluminescence (ECL) of tris(2,2'-bipyridyl)ruthenium(II) [Ru(bpy)(3) (2+)] is an active research area and includes the synthesis of ECL-active materials, mechanistic studies and broad applications. Extensive research has been focused on this area, due to its scientific and practical importance. In this mini-review we focus on the bio-related applications of ECL. After a brief introduction to Ru(bpy)(3) (2+) ECL and its mechanisms, its application in constructing an effective bioassay is discussed in detail. Three types of ECL assay are covered: DNA, immunoassay and functional nucleic acid sensors. Finally, future directions for these assays are discussed.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wei
authors.forename: Erkang
authors.initials: E
authors.lastname: Wang
mesh_terms: D052157:Aptamers, Nucleotide / Q000138:chemical synthesis / Q000737:chemistry*; D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis*; D004563:Electrochemistry; D007118:Immunoassay; D049449:Luminescence; D008163:Luminescent Measurements; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D052157:Aptamers, Nucleotide; D009942:Organometallic Compounds; C415768:tris(2,2'-bipyridyl)ruthenium(II); D004247:DNA