title: [Predicative value of 99mTc-MIBI scintimammography in neoadjuvant chemotherapeutic effect of patients with operable breast cancer].
abstract: OBJECTIVE
  To evaluate the relationship between the clearance rate of technetium-99m methoxyisobutylisonitrile ((99m)Tc-MIBI) in scintimammography and the efficacy of neoadjuvant chemotherapy (NCT) of patients with operable breast cancer.
  
  
  METHODS
  Seventy-eight patients with breast cancer underwent (99m)Tc-MIBI scintimammography at pre-NCT. And static planar images were taken at 10 min and 180 min post-scintimammography. The clearance rate was calculated in each patient. And the efficacy of NCT was evaluated after 2 cycles.
  
  
  RESULTS
  The clearance rates of patients with a poor or good efficacy of chemotherapy were 24.21% ± 6.38% (n = 14) and 14.13% ± 5.98% (n = 64) respectively. There was significant difference between two groups. And a significant correlation was observed between the efficacy of chemotherapy and the clearance rate of (99m)Tc-MIBI (r = -0.539, P < 0.001).
  
  
  CONCLUSIONS
  The scintimammography of (99m)Tc-MIBI may be employed to evaluate the efficacy of NCT.
authors.affiliation: Breast Diseases Center, Henan Cancer Hospital/Affiliated Cancer Hospital, Zhengzhou University, Zhengzhou 450008, China.
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Liu
authors.forename: Zhen-Duo
authors.initials: ZD
authors.lastname: Lu
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Lian-Fang
authors.initials: LF
authors.lastname: Li
authors.forename: Heng-Wei
authors.initials: HW
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Li
authors.forename: Shu-de
authors.initials: SD
authors.lastname: Cui
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi; D016896:Treatment Outcome
chemical_list: D017256:Technetium Tc 99m Sestamibi