title: The polycondensing temperature rather than time determines the degradation and drug release of poly(glycerol-sebacate) doped with 5-fluorouracil.
abstract: Poly(glycerol-sebacate) (PGS) is an elastomeric biodegradable polyester that could be used as biodegradable drug carrier. We have previously prepared PGS implants doped with 5-fluorouracil (5-FU-PGSs) and found that 5-FU-PGSs exhibited an initial burst of 5-FU release during in vitro degradation. The synthesis temperature and time are two of the most important reaction conditions for polymer synthesis. Therefore, in order to establish a controllable drug-release manner, we prepared a series of 5-FU-PGS with 2% weight of 5-FU under synthesis conditions with different polycondensing temperature and time and characterized the infrared spectrum properties, in vitro degradation and drug release. Results showed that the polycondensing temperature determined the mechanical properties, degradation and drug release of 5-FU-PGSs. With the polycondensing temperature increasing, the elastic modulus and hardness of 5-FU-PGSs increased, and the mass loss and 5-FU release rate decreased. The polycondensing time had no significant influence on the mechanical property, degradation and drug release of 5-FU-PGSs. We suggest that the polycondensing temperature is the factor to control the drug-release manner.
authors.affiliation: a Center for Biomedical Materials and Engineering, Harbin Engineering University, 145 Nantong Street, Nangang District, Harbin 150001, P. R. China. zhijiesun2005@yahoo.com.cn.
authors.forename: Zhi-Jie
authors.initials: ZJ
authors.lastname: Sun
authors.forename: Cheng-Wu
authors.initials: CW
authors.lastname: Sun
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.forename: Xi-Li
authors.initials: XL
authors.lastname: Lu
authors.forename: De-Li
authors.initials: DL
authors.lastname: Dong
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002470:Cell Survival; D002851:Chromatography, High Pressure Liquid; D003651:Decanoates / Q000138:chemical synthesis* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D065546:Drug Liberation; D055119:Elastic Modulus; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005990:Glycerol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D013696:Temperature; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D000964:Antimetabolites, Antineoplastic; D003651:Decanoates; D003692:Delayed-Action Preparations; D011108:Polymers; C469892:poly(glycerol-sebacate); D005990:Glycerol; D005472:Fluorouracil