title: Pd(II)-catalyzed intramolecular amidoarylation of alkenes with molecular oxygen as sole oxidant.
abstract: Stereoselective palladium-catalyzed synthesis of structurally versatile indoline derivatives, using molecular oxygen as the sole oxidant, is described. New C-N and C-C bonds form across an alkene in an intramolecular manner. The C-N bond-forming step proceeds via a syn-amidopalladation pathway. The moderate kinetic isotope effects (intramolecular KIE = 3.56) suggest that electrophilic aromatic substitution occurs in the arylation step.
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
authors.forename: Kai-Tai
authors.initials: KT
authors.lastname: Yip
authors.forename: Dan
authors.initials: D
authors.lastname: Yang