title: Schwannoma arising from the sublingual gland.
abstract: Sublingual gland tumors, especially mesenchymal tumors, are extremely rare. We describe the first reported case of schwannoma arising from the sublingual gland with details of the histopathologic and immunohistochemical features. A 70-year-old woman developed a painless swelling on the floor of the mouth. The excised material was sublingual gland tissue with an ovoid, grayish-yellow solid tumorous mass at the cut surface. The tumor was composed of proliferated spindle-shaped tumor cells exhibiting palisading patterns. In the center of the tumor, a small salivary gland component was recognized. Immunohistochemically, the tumor cells were strongly positive for S-100 protein but negative for neurofilament protein. The Ki-67 labeling index was 4.58. The clear presence of a remnant sublingual gland lobule in the present tumor provided convincing evidence that it was a schwannoma arising from the sublingual gland and thus the first of its type to be reported.
authors.affiliation: Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Chiba, Japan. okada.hiroyuki@nihon-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.forename: Shigeo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Hideto
authors.initials: H
authors.lastname: Tajima
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Akimoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Kaneda
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009442:Neurilemmoma / Q000378:metabolism / Q000473:pathology*; D013362:Sublingual Gland Neoplasms / Q000378:metabolism / Q000473:pathology*