title: RNAi genes pave their own way.
abstract: Heterochromatin formation in fission yeast and the role of RNAi in this process have been intensively studied. So far, however, nothing is known about the regulation of expression of RNAi components during these events. Gullerova and colleagues (pp. 556-568) reveal an autoregulatory loop that regulates the expression of RNAi genes and centromeric heterochromatin formation during the cell cycle. Gene orientation plays a surprising role in this process.
authors.affiliation: Hubrecht Institute-KNAW, University Medical Centre Utrecht, 3584 CT Utrecht, The Netherlands. r.ketting@hubrecht.eu
authors.forename: Leonie M
authors.initials: LM
authors.lastname: Kamminga
authors.forename: René F
authors.initials: RF
authors.lastname: Ketting
mesh_terms: D002453:Cell Cycle / Q000235:genetics; D002503:Centromere / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism*
chemical_list: D006570:Heterochromatin; D016601:RNA-Binding Proteins