title: [Changes of high-sensitivity CRP and insulin sensitivity index in children with obstructive sleep apnea hypopnea syndrome].
abstract: OBJECTIVE
  To investigate the levels of high-sensitivity CRP (hsCRP) and insulin sensitivity index (ISI) in children with obstructive sleep apnea hypopnea syndrome (OSAHS).
  
  
  METHODS
  Twenty-nine children with OSAHS and 22 children with primary snoring (PS) were enrolled. Polysomnography was performed. Body mass index (BMI), hsCRP, serum lipids, fasting plasma glucose (FPG), and insulin (INS) were measured. ISI was calculated.
  
  
  RESULTS
  The apnea hypopnea index (AHI) in the OSAHS group was higher than that in the PS group (13.2 ± 9.2 vs 1.2 ± 1.1; P<0.05). The lowest oxygen saturation (LSaO2) in the OSAHS group was lower than that in the PS group [(78.5 ± 5.4)% vs (87.4 ± 3.7)%; P<0.05]. The values of hsCRP in the OSAHS group was higher than those in the PS group (2.8 ± 2.7 mg/L vs 0.6 ± 0.9 mg/L; P<0.05). There were no significant differences in the ISI and serum lipids between the two groups. The hsCRP level was negatively correlated with LSaO2 in the OSAHS group (r=-0.531, P<0.05).
  
  
  CONCLUSIONS
  The hsCRP level increases in children with OSAHS. The increased hsCRP level might be associated with an increased risk of cardiovascular diseases.
authors.affiliation: Department of Pediatrics, Third Shenzhen People's Hospital, Guangdong Medical University, Shenzhen, Guangdong 518112, China. docdlk@tom.com
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Li-Kun
authors.initials: LK
authors.lastname: Duo
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D020181:Sleep Apnea, Obstructive / Q000097:blood*
chemical_list: D002097:C-Reactive Protein