title: The vasculogenesis--a possible histological identification criterion for the molar pregnancy.
abstract: The benign hydatidiform mole (partial and complete) practically represents an associated pathology of the first trimester miscarriage; it is considered that it represents the initial pathology, which, evolutionally, may be followed by the appearance of invasive mole and choriocarcinoma. The authors have studied clinical and cytogenetical 61 cases selected according to some specific criteria for the suspicion of molar pregnancy or hydropic abortion and 21 cases that represented the control group made by patients with normal pregnancy which have been presented for legal abortion. In all cases has been made a histological exam and has been studied the vasculogenesis by immunohistochemistry labeling for CD31 and CD34. Following-up the results has been established a number of histological and immunohistochemical criteria for the evaluation and differentiation of various molar pregnancy types and the vasculogenesis characteristics. The most important differential diagnosis criteria between partial and complete mole is represented by the trophoblast disposition and the atypical trophoblast in the complete mole.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania. liliana.novac@gmail.com
authors.forename: Liliana
authors.initials: L
authors.lastname: Novac
authors.forename: Mihaela
authors.initials: M
authors.lastname: Niculescu
authors.forename: Maria Magdalena
authors.initials: MM
authors.lastname: Manolea
authors.forename: D
authors.initials: D
authors.lastname: Iliescu
authors.forename: Claudia Valentina
authors.initials: CV
authors.lastname: Georgescu
authors.forename: Al
authors.initials: A
authors.lastname: Comănescu
authors.forename: N
authors.initials: N
authors.lastname: Cernea
authors.forename: Andreea
authors.initials: A
authors.lastname: Enache
mesh_terms: D000022:Abortion, Spontaneous / Q000473:pathology; D001808:Blood Vessels / Q000196:embryology*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis* / Q000473:pathology*; D007150:Immunohistochemistry; D038081:Organogenesis; D011247:Pregnancy; D014327:Trophoblasts / Q000473:pathology