title: Synthesis of N-(2-pyridyl)indoles via Pd(II)-catalyzed oxidative coupling.
abstract: Readily available Pd(II) chloride catalysts can catalyze selective and efficient oxidative coupling between N-aryl-2-aminopyridines and internal alkynes to yield N-(2-pyridyl)indoles. This process involves the ortho C-H activation of N-aryl-2-aminopyridines, and CuCl(2) was used as an oxidant. Compared to our previously reported Rh(III)-catalyzed synthesis of this class of product, this method is advantageous with a wider scope of alkynes and cost-effective Pd(II) catalysts. Molecular oxygen can be used as a terminal oxidant.
authors.affiliation: State Key Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, Jilin University, Changchun 130023, People's Republic of China.
authors.forename: Jinlei
authors.initials: J
authors.lastname: Chen
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Pang
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Sun
authors.forename: Xingwei
authors.initials: X
authors.lastname: Li