title: Association study: SLC6A18 gene and myocardial infarction.
abstract: OBJECTIVE
  SLC6A18 (solute carrier family 6, member 18) acts as a specific transporter for neurotransmitters, amino acids and osmolytes such as betaine, taurine and creatine. The aim of the present study was to investigate the relationship between the human SLC6A18 gene and myocardial infarction (MI) in a Japanese population.
  
  
  METHODS
  Using 5 single nucleotide polymorphisms in the SLC6A18 gene (rs7728646, rs4975625, rs12522796, rs4975623 and rs7447815) we performed a case-control study based on each SNP and haplotype in 289 MI patients and 223 controls.
  
  
  RESULTS
  Logistic regression analysis revealed that the frequency of the CC+CG genotype of rs7447815 was significantly higher in all patients and the male MI patients than in controls (P=0.005, P=0.036, respectively). The frequency of the T-C haplotype (rs7728646-rs7447815) was significantly higher for the MI patients when compared with controls (P=0.037).
  
  
  CONCLUSIONS
  These results suggest that SLC6A18 or neighboring genes are associated with increased susceptibility to MI.
authors.affiliation: Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Shimodaira
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakazato
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Izumi
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Soma
authors.forename: Koichi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Noriko
authors.initials: N
authors.lastname: Aoi
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D016017:Odds Ratio; D050480:Plasma Membrane Neurotransmitter Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D050480:Plasma Membrane Neurotransmitter Transport Proteins; C532591:Slc6a18 protein, human