title: Prevalence and effect of hemoglobin E disorders on Hba1c and lipid profile of diabetic patients at Surin Hospital.
abstract: OBJECTIVE
  To evaluate the prevalence of hemoglobin E disorders (HbE) and their characteristics in diabetic patients at Surin Hospital. Effects of HbE on HbA1c measurement and other variables in diabetic patients were also studied.
  
  
  METHODS
  A cross-sectional study was performed. One thousand nine hundred seventy eight patients were recruited randomly using a systemic random sampling method HbE screening test and Hb typing was performed HbA lc was measured by turbidimetric inhibition immunoassay.
  
  
  RESULTS
  The prevalence of homozygous HbE (HbEE) and HbE trait were 7.9% and 35.3% respectively. When compared with the negative screening group, the variables that were significantly higher in the HbEE group were hemoglobin A1c (HbA1c) < 6.5% (p < 0.010), HbA1c < 7% (p < 0.010), serum cholesterol level (CHOL) < 200 mg/dl (p < 0.010), low density lipoprotein (LDL) < 100 mg/dl (p = 0.021), and anemia by Hb measurement (p < 0.010). The adjusted odds ratio and 95% confidence interval (CI) of HbA1c < 6.5% and < 7% in HbEE when compared with the negative screening group were 5.16 (3.55-7.50) and 4.60 (3.04-6.97) respectively The means of HbA1c, Hb, CHOL, and LDL in HbEE were significantly lower than the other groups (p < 0.010 in all variables). The adjusted odds ratio and 95% CI of HbA1c < 6.5% and < 7% in HbE trait when compared with the negative screening group were 1.12 (1.01-1.24) and 1.17 (1.06-1.29) respectively.
  
  
  CONCLUSIONS
  Hemoglobin E disorders are highly prevalent in diabetes patients at Surin Hospital. HbA1c, CHOL, and LDL were significantly lower in diabetic patients with HbEE.
authors.affiliation: Department of Medicine, Surin Hospital, Surin, Thailand. wasuntsrisurin@gmail.com
authors.forename: Wasunt
authors.initials: W
authors.lastname: Srisurin
mesh_terms: D017677:Age Distribution; D000368:Aged; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006446:Hemoglobin E / Q000032:analysis*; D006785:Hospitals, University; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution; D013785:Thailand / Q000453:epidemiology
chemical_list: D006442:Glycated Hemoglobin; D006446:Hemoglobin E; D008055:Lipids