title: [Research progress of bone marrow mesenchymal stem cells in acute lung injury].
abstract: OBJECTIVE
  To review the basic research, the clinical progress, and the mechanism of bone marrow mesenchymal stem cells (BMSCs) in acute lung injury (ALI).
  
  
  METHODS
  The literature concerning the basic and clinical researches of BMSCs in ALI was reviewed.
  
  
  RESULTS
  BMSCs can take the initiative to "homing" the site of lung injury and take participate in repair by means of differentiation, meanwhile BMSCs could regulate and balance local and systematic inflammatory response and immune disorders in ALI. Currently, the mechanism of BMSCs on anti-inflammation and immune regulation in ALI is not clear.
  
  
  CONCLUSIONS
  BMSCs have comprehensive biological effect on ALI, providing a potential clinical treatment and also laying the foundation for gene therapy and stem cell therapy of ALI in the future.
authors.affiliation: Department of Critical Care Medicine, the First Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, PR China. 13907919783@139.com
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Guanghua
authors.initials: G
authors.lastname: Guo
mesh_terms: D055371:Acute Lung Injury / Q000628:therapy*; D001854:Bone Marrow Cells / Q000166:cytology*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*