title: Pharmacological adherence to oral anticoagulant and factors that influence the international normalized ratio stability.
abstract: Cross-sectional study developed to relate the international normalized ratio (INR), used as a parameter to monitor the levels of blood clotting, stability to adherence, age, level of education, socioeconomic level, interaction with other drugs, comorbidities, vitamin K intake, anticoagulation time and drug cost. 156 patients were included, mean age 57 ± 13 years, (53.8%) male, 61 (39.1%) had high adherence, 91 (58.3%) medium and 4 (2.6%) low adherence to treatment, 117 (75%) had INR stability up to 50% and 39 (25%) > 75%, patients with shorter time of anticoagulation presented higher stability, those who spent less on the drug remained more stable and had better adherence. It was concluded that more than 90% of patients had high and medium adherence and that the anticoagulation time and drug cost were the factors related to the anticoagulation stability.
authors.affiliation: Hospital de Clínicas de Porto Alegre, Escola de Enfermagem, Universidade Federal do Rio Grande do Sul, RS, Brazil. chriswavila@yahoo.com.br
authors.forename: Christiane Wahast
authors.initials: CW
authors.lastname: Avila
authors.forename: Graziella Badin
authors.initials: GB
authors.lastname: Aliti
authors.forename: Maria Karolina Ferreira
authors.initials: MK
authors.lastname: Feijó
authors.forename: Eneida Rejane
authors.initials: ER
authors.lastname: Rabelo
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D016903:Drug Monitoring
chemical_list: D000925:Anticoagulants