title: Organocatalytic chemoselective asymmetric N-allylic alkylation of enamides.
abstract: The first Lewis base-catalysed chemoselective asymmetric N-allylic alkylation of enamides with Morita-Baylis-Hillman carbonates has been developed, which affords multifunctional products in moderate to high enantioselectivity (up to 92% ee).
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Ji-Rong
authors.initials: JR
authors.lastname: Huang
authors.forename: Hai-Lei
authors.initials: HL
authors.lastname: Cui
authors.forename: Jie
authors.initials: J
authors.lastname: Lei
authors.forename: Xun-Hao
authors.initials: XH
authors.lastname: Sun
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000478:Alkylation; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D058115:Lewis Bases / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides; D058115:Lewis Bases