title: Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.
abstract: BACKGROUND
  A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese. This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world.
  
  
  RESULTS
  We have assessed the relationship between these two single nucleotide polymorphisms (rs3077 and rs9277535) and chronic hepatitis B infection in two independent case-control studies. The first population in Chinese Han included 736 patients and 782 spontaneously recovered controls. The second set was established in Chinese Zhuang minority of 177 patients and 208 controls. Both A alleles of rs3077 and rs9277535 significantly deceased the risk to CHB in Chinese Han (OR = 0.540, 95%CI: 0.464-0.628, P = 4.068×10(-16) and OR = 0.696, 95%CI: 0.601-0.806, P = 1.062×10(-6), respectively). Conceivably, rs9277535 was found to be associated with decreased risk of the disease in Chinese Zhuang, with an OR of 0.606 (95%CI, 0.441-0.833, P = 0.002).
  
  
  CONCLUSIONS
  Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. These findings might provide clues to develop screening and surveillance strategies.
authors.affiliation: Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Xiao-Pan
authors.initials: XP
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Da-Hai
authors.initials: DH
authors.lastname: Zhu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Li
authors.forename: Yao
authors.initials: Y
authors.lastname: Tian
authors.forename: Rong-Cheng
authors.initials: RC
authors.lastname: Li
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Li
authors.forename: Xinlin
authors.initials: X
authors.lastname: Zhu
authors.forename: Jun-Hong
authors.initials: JH
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Cai
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Miao
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006515:Hepatitis B virus / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000235:genetics* / Q000821:virology; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D016896:Treatment Outcome