title: [Prognosis of surgically treated large cell neuroendocrine carcinoma].
abstract: Large cell neuroendocrine carcinoma (LCNEC) is a relatively rare tumor in malignant lung neoplasms. The prognosis of LCNEC is poor and there is no consensus on the treatment for LCNEC. We report our retrospective assessment of 11 patients of LCNEC from 1999 to 2008. Three of 11 patients had malignant exudate at thoracotomy. Seven patients received limited resection. There was a recurrence even after complete surgical resection in its early stage. Four patients received platinum-based chemotherapy for adjuvant therapy or recurrence. The response to platinum-based chemotherapy was relatively good and may be comparable to that of small cell lung cancer. The overall 5-year survival rate was 30.3%. Pulmonary LCNEC represents an aggressive tumor and multimodal treatment is required.
authors.affiliation: Department of General Thoracic, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Matsuura
authors.forename: Nariyasu
authors.initials: N
authors.lastname: Nakashima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Igai
authors.forename: Shintarou
authors.initials: S
authors.lastname: Tarumi
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Chang
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Misaki
authors.forename: Dage
authors.initials: D
authors.lastname: Liu
authors.forename: Tetsuhiko
authors.initials: T
authors.lastname: Go
authors.forename: Shinya
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Cheng-Long
authors.initials: CL
authors.lastname: Huang
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Yokomise
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018287:Carcinoma, Large Cell / Q000401:mortality / Q000601:surgery*; D018278:Carcinoma, Neuroendocrine / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate