title: Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass.
abstract: OBJECTIVE
  The SH3-domain GRB2-like (endophilin)-interacting protein 1 (SGIP1) gene has been shown to be differentially expressed in the hypothalamus of lean versus obese Israeli sand rats (Psammomys obesus), and is suspected of having a role in regulating food intake. The purpose of this study was to assess the role of genetic variation in SGIP1 in human disease.
  
  
  METHODS
  We performed single-nucleotide polymorphism (SNP) genotyping in a large family pedigree cohort from the island of Mauritius. The Mauritius Family Study (MFS) consists of 400 individuals from 24 Indo-Mauritian families recruited from the genetically homogeneous population of Mauritius. We measured markers of the metabolic syndrome, including diabetes and obesity-related phenotypes such as fasting plasma glucose, waist:hip ratio, body mass index and fat mass.
  
  
  RESULTS
  Statistical genetic analysis revealed associations between SGIP1 polymorphisms and fat mass (in kilograms) as measured by bioimpedance. SNP genotyping identified associations between several genetic variants and fat mass, with the strongest association for rs2146905 (P=4.7 × 10(-5)). A strong allelic effect was noted for several SNPs where fat mass was reduced by up to 9.4% for individuals homozygous for the minor allele.
  
  
  CONCLUSIONS
  Our results show association between genetic variants in SGIP1 and fat mass. We provide evidence that variation in SGIP1 is a potentially important determinant of obesity-related traits in humans.
authors.affiliation: Genomics and Systems Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Cummings
authors.forename: K A
authors.initials: KA
authors.lastname: Shields
authors.forename: J E
authors.initials: JE
authors.lastname: Curran
authors.forename: K
authors.initials: K
authors.lastname: Bozaoglu
authors.forename: J
authors.initials: J
authors.lastname: Trevaskis
authors.forename: K
authors.initials: K
authors.lastname: Gluschenko
authors.forename: G
authors.initials: G
authors.lastname: Cai
authors.forename: A G
authors.initials: AG
authors.lastname: Comuzzie
authors.forename: T D
authors.initials: TD
authors.lastname: Dyer
authors.forename: K R
authors.initials: KR
authors.lastname: Walder
authors.forename: P
authors.initials: P
authors.lastname: Zimmet
authors.forename: G R
authors.initials: GR
authors.lastname: Collier
authors.forename: J
authors.initials: J
authors.lastname: Blangero
authors.forename: J B M
authors.initials: JB
authors.lastname: Jowett
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D000818:Animals; D001823:Body Composition / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004435:Eating / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008436:Mauritius / Q000453:epidemiology; D008565:Membrane Proteins; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D011506:Proteins / Q000235:genetics*; D051381:Rats; D055815:Young Adult; D018909:src Homology Domains / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D008565:Membrane Proteins; D011506:Proteins; C523897:SGIP1 protein, human; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human