title: Decisions to update comparative drug effectiveness reviews vary based on type of new evidence.
abstract: OBJECTIVE
  To determine the time to and key factors associated with decision to update comparative effectiveness of reviews of drugs based on periodic scans of new evidence.
  
  
  METHODS
  Based on periodic scans of new evidence, we analyzed 69 decisions on whether to update for 41 comparative effectiveness reviews conducted for the Drug Effectiveness Review Project. We used the Kaplan-Meier product limit method to estimate mean time to update and generalized estimating equation logistic regression to estimate associations between updating decisions and review topic or characteristics of new evidence.
  
  
  RESULTS
  Mean time to update was 24.9 months. Significant predictors of a decision to update were identification of a new drug (odds ratio [OR]: 5.71; 95% confidence interval [CI]: 1.68-19.44) and the number of new relevant trials (OR: 1.06; 95% CI: 1.03-1.10). Compared with nonpsychiatric topics, psychiatric topics were most rapidly developing (mean new relevant citations: 38.4 vs. 8.2; P=0.0127) and were updated at a faster pace (mean survival time: 10.2 vs. 27.5 months; P<0.0001).
  
  
  CONCLUSIONS
  Using periodic scans of new evidence, updating should be considered yearly for rapidly developing topics and biannually for other topics.
authors.affiliation: Department of Medical Informatics and Clinical Epidemiology, Oregon Evidence-based Practice Center, Oregon Health and Science University, Portland, OR 97217, USA.
authors.forename: Kim
authors.initials: K
authors.lastname: Peterson
authors.forename: Marian S
authors.initials: MS
authors.lastname: McDonagh
authors.forename: Rongwei
authors.initials: R
authors.lastname: Fu
mesh_terms: D002170:Canada; D002986:Clinical Trials as Topic; D057186:Comparative Effectiveness Research / Q000706:statistics & numerical data*; D003661:Decision Support Techniques; D004341:Drug Evaluation; D019317:Evidence-Based Medicine; D006291:Health Policy; D006801:Humans; D007391:International Cooperation; D053208:Kaplan-Meier Estimate; D016239:MEDLINE; D004364:Pharmaceutical Preparations; D011570:Psychiatry; D011643:Publishing; D012196:Review Literature as Topic; D014481:United States
chemical_list: D004364:Pharmaceutical Preparations