title: Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema.
abstract: Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to the last measurement between pleural fluid and serum values was only 0.125 (12.5%), with pleural fluid concentrations ranging between 0.67 and 0.88 μg/ml.
authors.affiliation: NIH Clinical Center, Pharmacy Department, National Heart Lung and Blood Instititute, Bethesda, MD, USA.
authors.forename: Brad
authors.initials: B
authors.lastname: Moriyama
authors.forename: Marisa
authors.initials: M
authors.lastname: Ditullio
authors.forename: Eleanor
authors.initials: E
authors.lastname: Wilson
authors.forename: Stacey A
authors.initials: SA
authors.lastname: Henning
authors.forename: Scott R
authors.initials: SR
authors.lastname: Penzak
authors.forename: Robert L
authors.initials: RL
authors.lastname: Danner
authors.forename: Gennethel
authors.initials: G
authors.lastname: Pennick
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Zelazny
authors.forename: Juan
authors.initials: J
authors.lastname: Gea-Banacloche
authors.forename: A John
authors.initials: AJ
authors.lastname: Barrett
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000328:Adult; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects* / Q000472:pathogenicity*; D054714:Echinocandins / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D004653:Empyema / Q000188:drug therapy* / Q000382:microbiology*; D016724:Empyema, Pleural / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008297:Male
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin