title: Fatal mycotic aneurysms due to Scedosporium and Pseudallescheria infection.
abstract: Angioinvasive complications of Scedosporium infections are rare. We report two cases of mycotic aneurysm, following apparent localized infection, due to Scedosporium apiospermum and Pseudallescheria boydii. The thoracoabdominal aorta was affected in one patient, and cerebral vessels were affected in the other. Despite voriconazole therapy and surgical resection, the patients died. Previously reported cases are reviewed.
authors.affiliation: Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia.
authors.forename: Adrian
authors.initials: A
authors.lastname: Ong
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Blyth
authors.forename: Rosamma
authors.initials: R
authors.lastname: Bency
authors.forename: Mauro
authors.initials: M
authors.lastname: Vicaretti
authors.forename: Azian
authors.initials: A
authors.lastname: Harun
authors.forename: Wieland
authors.initials: W
authors.lastname: Meyer
authors.forename: Meena
authors.initials: M
authors.lastname: Shingde
authors.forename: Nicky
authors.initials: N
authors.lastname: Gilroy
authors.forename: Jeremy
authors.initials: J
authors.lastname: Chapman
authors.forename: Sharon C-A
authors.initials: SC
authors.lastname: Chen
mesh_terms: D000785:Aneurysm, Infected / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D000935:Antifungal Agents / Q000008:administration & dosage; D001011:Aorta / Q000473:pathology; D002536:Cerebral Arteries / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D008271:Mycetoma / Q000150:complications* / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D011541:Pseudallescheria / Q000302:isolation & purification*; D011743:Pyrimidines / Q000008:administration & dosage; D021681:Scedosporium / Q000302:isolation & purification*; D014230:Triazoles / Q000008:administration & dosage; D014656:Vascular Surgical Procedures / Q000379:methods; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole