title: Changes in antibiotic distribution due to pancreatitis.
abstract: This work sought to define how pancreatitis affected antibiotic distribution in a perfused rat pancreas model. The distribution kinetics of four antibiotics were examined in control animals and animals with pancreatitis. Meropenem and piperacillin distributed into the extracellular space, and their distribution kinetics were unaffected by pancreatitis. In contrast, in pancreatic cells from animals with pancreatitis, ciprofloxacin showed a reduced uptake and clindamycin showed a reduced distribution.
authors.affiliation: Therapeutics Research Centre, School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.
authors.forename: Kent J
authors.initials: KJ
authors.lastname: Fanning
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Robertson
authors.forename: Johannes B
authors.initials: JB
authors.lastname: Prins
authors.forename: Michael S
authors.initials: MS
authors.lastname: Roberts
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000493:pharmacokinetics; D002981:Clindamycin / Q000493:pharmacokinetics; D008297:Male; D000077731:Meropenem; D009947:Organotin Compounds; D010195:Pancreatitis / Q000139:chemically induced / Q000378:metabolism*; D010878:Piperacillin / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013845:Thienamycins / Q000493:pharmacokinetics
chemical_list: D000900:Anti-Bacterial Agents; D009947:Organotin Compounds; D013845:Thienamycins; D002981:Clindamycin; D002939:Ciprofloxacin; D000077731:Meropenem; C020735:dibutyldichlorotin; D010878:Piperacillin