title: Coexistence of Takayasu's arteritis with familial Mediterranean fever.
abstract: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by recurrent self-limited attacks of fever, accompanied with peritonitis, pleuritis or arthritis. It is well known that FMF may coexist with vasculitic pathologies, especially with those involving small and medium vessels. Among the vasculitic pathologies reported to be associated with FMF, Henoch-Schönlein purpura and polyarteritis nodosa come the first, possibly followed up by protracted febrile myalgia. However, coexistence of FMF with any large vessel vasculitis has not been reported to date. Here, we present a case with FMF who later developed Takayasu arteritis, with a severe disease course, being resistant to corticosteroids and conventional immunosuppressive agents, and requiring infliximab treatment.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Ege University School of Medicine, 80. Sk. No: 27/3, 35040, Bornova, Izmir, Turkey.
authors.forename: Figen Yargucu
authors.initials: FY
authors.lastname: Zihni
authors.forename: Melike
authors.initials: M
authors.lastname: Kalfa
authors.forename: Pınar Talu
authors.initials: PT
authors.lastname: Ocakçı
authors.forename: Figen
authors.initials: F
authors.lastname: Tarhan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Parildar
authors.forename: Gokhan
authors.initials: G
authors.lastname: Keser
authors.forename: Kenan
authors.initials: K
authors.lastname: Aksu
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D003078:Colchicine / Q000627:therapeutic use; D004351:Drug Resistance; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000069285:Infliximab; D008297:Male; D012720:Severity of Illness Index; D013625:Takayasu Arteritis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D017211:Treatment Failure; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D003078:Colchicine