title: The sequence d(CGGCGGCCGC) self-assembles into a two dimensional rhombic DNA lattice.
abstract: We report here the crystal structure of the partially self-complementary decameric sequence d(CGGCGGCCGC), which self assembles to form a four-way junction with sticky ends. Each junction binds to four others through Watson-Crick base pairing at the sticky ends to form a rhombic structure. The rhombuses bind to each other and form two dimensional tiles. The tiles stack to form the crystal. The crystal diffracted in the space group P1 to a resolution of 2.5Å. The junction has the anti-parallel stacked-X conformation like other junction structures, though the formation of the rhombic net noticeably alters the details of the junction geometry.
authors.affiliation: CAS in Crystallography and Biophysics, University of Madras, Chennai 600 025, India.
authors.forename: S
authors.initials: S
authors.lastname: Venkadesh
authors.forename: P K
authors.initials: PK
authors.lastname: Mandal
authors.forename: N
authors.initials: N
authors.lastname: Gautham
mesh_terms: D020029:Base Pairing; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D020862:GC Rich Sequence; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA