title: Effects of coenzyme Q10 on salivary secretion.
abstract: OBJECTIVE
  Dry mouth is a condition associated with reduced salivary secretion and is thought to be related to aging. This study was conducted to test whether reduced (ubiquinol) or oxidized (ubiquinone) forms of CoQ10 affect salivary secretion and salivary CoQ10 content before and after treatment.
  
  
  METHODS
  Sixty-six patients were given either ubiquinol or ubiquinone orally at a dosage of 100 mg/day, or a placebo for 1 month, and salivary secretion and salivary CoQ10 content were analyzed before and after treatment.
  
  
  RESULTS
  Both parameters were significantly improved following treatment with either form of CoQ10, suggesting the effectiveness of CoQ10 in attenuating dry mouth symptoms.
  
  
  CONCLUSIONS
  CoQ10 was locally detected in salivary glands, suggesting that orally administered CoQ10 was transported to the salivary glands via the blood stream and exerted its activity, improving salivary secretion.
authors.affiliation: Department of Pathology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.
authors.forename: Koufuchi
authors.initials: K
authors.lastname: Ryo
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ito
authors.forename: Rie
authors.initials: R
authors.lastname: Takatori
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tai
authors.forename: Kazumune
authors.initials: K
authors.lastname: Arikawa
authors.forename: Taro
authors.initials: T
authors.lastname: Seido
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamada
authors.forename: Keiko
authors.initials: K
authors.lastname: Shinpo
authors.forename: Yoh
authors.initials: Y
authors.lastname: Tamaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Fujii
authors.forename: Yorihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Saito
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012472:Salivation / Q000187:drug effects*; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D014451:Ubiquinone; C024989:coenzyme Q10; C003741:ubiquinol