title: [Implication of radiological pattern in the prognosis of oligodendroglial tumors: correlation with genetic profile].
abstract: BACKGROUND
  1p19q loss of heterozygosity (LOH1p19q) in oligodendroglial tumors has shown to be prognostic of prolonged survival and predictive of therapeutic responsiveness. During the last years, research is actively being directed to the discovery of radiological characteristics related to LOH1p19q. AIMS. To confirm the existence of molecular heterogeneity in oligodendroglial tumors in relation to their anatomic distribution, and to evaluate the correlation between molecular profile and other radiological and clinical characteristics and their prognostic impact.
  
  
  METHODS
  Fifty-four patients with oligodendroglial tumors managed according to a previously established protocol were included. Preoperative SE T1, T1 post-gadolinium and T2 magnetic resonance images were reviewed by two independent neuroradiologists, blinded to clinical and molecular information. LOH analysis was assessed from paired tumor-blood DNA acid samples.
  
  
  RESULTS
  LOH1p was highly associated with LOH19q (p < 0.0001), LOH1p (odds ratio, OR = 6.19; 95% confidence interval, 95% CI = 1.66-22.68; p = 0.004), LOH19q (OR = 7.59; 95% CI = 1.84-31.34; p = 0.006) and LOH1p19q (OR = 5.38; 95% CI = 1.51-19.13; p = 0.007) were found to be more frequent in tumors located in the frontal lobe. Frontal location (hazard ratio, HR = 4.499; 95% CI = 1.027-193.708; p = 0.046), ring enhancement (HR = 0.213; 95% CI = 0.065-0.700; p = 0.011) and extent of resection (HR = 9.231; 95% CI = 1.737-49.050; p = 0.009) resulted independent prognostic factors for overall survival in the multivariate analysis.
  
  
  CONCLUSIONS
  Glioma classification aims to better define patients prognosis. Besides histological and immunohistochemical analyses, molecular information has become of great importance. Our results indicate that the evaluation of some MR features may also be useful. Efforts must be directed toward the use of every available resource at each institution.
authors.affiliation: Servicio de Neurocirugía, Hospital Universitario Son Dureta, Palma de Mallorca, España.
authors.forename: Marta
authors.initials: M
authors.lastname: Brell
authors.forename: Sara
authors.initials: S
authors.lastname: Castañer
authors.forename: Teresa
authors.initials: T
authors.lastname: Pujol-Farré
authors.forename: Susana
authors.initials: S
authors.lastname: Boluda
authors.forename: Teresa
authors.initials: T
authors.lastname: Ribalta
authors.forename: Jordi
authors.initials: J
authors.lastname: Bruna
authors.forename: María
authors.initials: M
authors.lastname: Martínez
authors.forename: Eugenia
authors.initials: E
authors.lastname: Verger
authors.forename: Salvador
authors.initials: S
authors.lastname: Villà
authors.forename: Nuria
authors.initials: N
authors.lastname: Viñolas
authors.forename: Miguel
authors.initials: M
authors.lastname: Gil
authors.forename: Francesc
authors.initials: F
authors.lastname: Graus
authors.forename: Avelina
authors.initials: A
authors.lastname: Tortosa-Moreno
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D011859:Radiography; D015996:Survival Rate; D055815:Young Adult