title: Decision tree analysis of treatment strategies for mild and moderate cases of clinical mastitis occurring in early lactation.
abstract: The objective of this study was to develop a decision tree to evaluate the economic impact of different durations of intramammary treatment for the first case of mild or moderate clinical mastitis (CM) occurring in early lactation with various scenarios of pathogen distributions and use of on-farm culture. The tree included 2 decision and 3 probability events. The first decision evaluated use of on-farm culture (OFC; 2 programs using OFC and 1 not using OFC) and the second decision evaluated treatment strategies (no intramammary antimicrobials or antimicrobials administered for 2, 5, or 8 d). The tree included probabilities for the distribution of etiologies (gram-positive, gram-negative, or no growth), bacteriological cure, and recurrence. The economic consequences of mastitis included costs of diagnosis and initial treatment, additional treatments, labor, discarded milk, milk production losses due to clinical and subclinical mastitis, culling, and transmission of infection to other cows (only for CM caused by Staphylococcus aureus). Pathogen-specific estimates for bacteriological cure and milk losses were used. The economically optimal path for several scenarios was determined by comparison of expected monetary values. For most scenarios, the optimal economic strategy was to treat CM caused by gram-positive pathogens for 2 d and to avoid antimicrobials for CM cases caused by gram-negative pathogens or when no pathogen was recovered. Use of extended intramammary antimicrobial therapy (5 or 8 d) resulted in the least expected monetary values.
authors.affiliation: Department of Dairy Science, University of Wisconsin, Madison 53706, USA.
authors.forename: C
authors.initials: C
authors.lastname: Pinzón-Sánchez
authors.forename: V E
authors.initials: VE
authors.lastname: Cabrera
authors.forename: P L
authors.initials: PL
authors.lastname: Ruegg
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D003612:Dairying / Q000191:economics / Q000379:methods*; D003663:Decision Trees; D004334:Drug Administration Schedule / Q000662:veterinary; D005260:Female; D007774:Lactation / Q000502:physiology*; D008321:Mammary Glands, Animal; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000191:economics / Q000382:microbiology; D008892:Milk / Q000191:economics / Q000382:microbiology; D018803:Models, Economic; D011336:Probability; D012720:Severity of Illness Index; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents