title: A comparison of chitosan-silica and sodium starch glycolate as disintegrants for spheronized extruded microcrystalline cellulose pellets.
abstract: Chitosan-silica coprecipitate (C-S) has recently been proposed as a tablet disintegrant. In this study we compared it with a 1:1 physical mixture of chitosan and silica (C/S) at the same composition as the coprecipitate, and with the widely used commercial disintegrant sodium starch glycolate (SSG), as regards to its behavior in spheronized extruded pellets of microcrystalline cellulose (MCC) containing hydrochlorothiazide as a typical poorly water-soluble drug. In all three cases, possible synergism between the disintegrant (0-5%) and sorbitol (0-50%) was also evaluated. All the formulations examined exhibited appropriate morphology and had satisfactory mechanical and flow properties. Drug release depended mainly on sorbitol content, however C-S accelerated drug release at all sorbitol levels (the fastest release was from 50% sorbitol pellets with C-S, which disintegrated), whereas C/S did not vary drug release from pellets, and SSG depressed drug release, especially from 50% sorbitol pellets.
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Goyanes
authors.forename: Consuelo
authors.initials: C
authors.lastname: Souto
authors.forename: Ramón
authors.initials: R
authors.lastname: Martínez-Pacheco
mesh_terms: D002482:Cellulose / Q000008:administration & dosage*; D048271:Chitosan / Q000008:administration & dosage*; D004304:Dosage Forms; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D005079:Excipients / Q000008:administration & dosage; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000008:administration & dosage*; D012995:Solubility; D013213:Starch / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D004304:Dosage Forms; D005079:Excipients; D012822:Silicon Dioxide; D002482:Cellulose; D013213:Starch; D048271:Chitosan; C048390:sodium starch glycolate; C109691:microcrystalline cellulose