title: Palladium-catalyzed three-component transformation of homoallenols: a regio- and stereoselective route to 1,5-amino alcohols.
abstract: A palladium-catalyzed three-component transformation of enantioenriched homoallenols with aryl halides and amines has been developed to selectively afford (Z)-configured 1,5-amino alcohols in good-to-excellent yields without any epimerization.
authors.affiliation: Centre for Synthesis and Chemical Biology (CSCB), School of Chemistry and Chemical Biology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Miriam
authors.initials: M
authors.lastname: Aylward
authors.forename: Vincent
authors.initials: V
authors.lastname: Coeffard
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Guiry
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000605:Amino Alcohols; D010165:Palladium