title: New trends in diffusion-weighted magnetic resonance imaging as a tool in differentiation of serous cystadenoma and mucinous cystic tumor: a prospective study.
abstract: OBJECTIVE
  Pancreatic cystic lesions are increasingly being recognized. Magnetic resonance imaging (MRI) is the method that brings the greatest amount of information about the morphologic features of pancreatic cystic lesions. To establish if diffusion-weighted MRI (DW-MRI) can be used as a tool to differentiate mucinous from nonmucinous lesions.
  
  
  METHODS
  Fifty-six patients with pancreatic cystic lesions (benign, n = 46; malignant, n = 10) were prospectively evaluated with DW-MRI in order to differentiate mucinous from nonmucinous lesions. Final diagnosis was obtained by follow-up (n = 31), surgery (n = 16) or endoscopic ultrasound-guided fine needle aspiration (n = 9). Serous cystadenoma was identified in 32 (57%) patients.
  
  
  RESULTS
  The threshold value established for the differentiation of mucinous from nonmucinous lesions was 2,230.06 s/mm(2) for ADC of 700. DWI-MRI behavior between mucinous and nonmucinous groups revealed sensitivity, specificity, positive predictive value, negative predictive value and accuracy to be 80, 98, 92, 93 and 93%, respectively (p < 0.01, power of sample = 1.0). In the comparison of the diffusion behavior between mucinous (n = 13) and serous (n = 32) lesions, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 100, 97, 92, 100 and 98%, respectively (p < 0.01, power of sample = 1.0). The results of endoscopic ultrasound-guided fine needle aspiration were similar to those of DW-MRI.
  
  
  CONCLUSIONS
  DW-MRI can be included as part of the array of tools to differentiate mucinous from nonmucinous lesions and can help in the management of pancreatic cystic lesions. and IAP.
authors.affiliation: Departments of Gastrointestinal Surgery, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Schraibman
authors.forename: Suzan Menasce
authors.initials: SM
authors.lastname: Goldman
authors.forename: José Celso
authors.initials: JC
authors.lastname: Ardengh
authors.forename: Alberto
authors.initials: A
authors.lastname: Goldenberg
authors.forename: Edson
authors.initials: E
authors.lastname: Lobo
authors.forename: Marcelo Moura
authors.initials: MM
authors.lastname: Linhares
authors.forename: Adriano Mizziara
authors.initials: AM
authors.lastname: Gonzales
authors.forename: Nitamar
authors.initials: N
authors.lastname: Abdala
authors.forename: Thiago Giansante
authors.initials: TG
authors.lastname: Abud
authors.forename: Sérgio Aron
authors.initials: SA
authors.lastname: Ajzen
authors.forename: Andrea
authors.initials: A
authors.lastname: Jackowsky
authors.forename: Jacob
authors.initials: J
authors.lastname: Szejnfeld
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D044963:Biopsy, Fine-Needle; D018293:Cystadenoma, Serous / Q000175:diagnosis* / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism; D010181:Pancreatic Cyst; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D010192:Pancreatic Pseudocyst / Q000175:diagnosis* / Q000378:metabolism; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results
chemical_list: D014408:Biomarkers, Tumor; D009077:Mucins