title: BCGiosis as a presenting feature of a child with chronic granulomatous disease.
abstract: Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in some regions, could lead to serious complication ranging from local disease (known as BCGitis) to disseminated disease (BCGosis) in a group of patients with primary immunodeficiency diseases. We are reporting here a 3.5 year-old girl with a history of prolonged BCGitis, which developed to disseminated disease without any other special features. Immunological studies with nitro-blue tetrazolium test confirmed the diagnosis of chronic granulomatous disease in this patient. Chronic granulomatous disease should be considered in the list of differential diagnosis in all children with BCGosis, even in the absence of any other manifestations related to immunodeficiency.
authors.affiliation: Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Movahedi
authors.forename: Sayna
authors.initials: S
authors.lastname: Norouzi
authors.forename: Setareh
authors.initials: S
authors.lastname: Mamishi
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D001500:BCG Vaccine / Q000009:adverse effects*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000175:diagnosis*; D006801:Humans
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine