title: Immunopathogenesis of severe asthma.
abstract: Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale for example genome, cell or whole organ physiology. In this review we shall summarise the current knowledge of the immunopathogenesis of severe asthma integrated across multiple scales to provide the insights into the structure function relationships required to begin to unravel the complexity of severe asthma.
authors.affiliation: Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, UK. ceb17@le.ac.uk
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Brightling
authors.forename: Sumit
authors.initials: S
authors.lastname: Gupta
authors.forename: Fay
authors.initials: F
authors.lastname: Hollins
authors.forename: Amanda
authors.initials: A
authors.lastname: Sutcliffe
authors.forename: Yassine
authors.initials: Y
authors.lastname: Amrani
mesh_terms: D056151:Airway Remodeling / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000209:etiology / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008407:Mast Cells / Q000276:immunology; D012720:Severity of Illness Index; D015398:Signal Transduction / Q000276:immunology