title: Analgesic, anti-inflammatory and antiulcer activity of nitric oxide releasing ester derivatives of indomethacin.
abstract: Analgesic, antiinflammatory and antiulcer activity of newly synthesized nitric oxide (NO) releasing ester derivatives of indomethacin were evaluated in rats. Synthetic compounds (NB-02, NP-02 and NE-02) 6 mg/kg, po each significantly (P < 0.01) increased the tail flick reaction time in rats. Antinociceptive effects of two derivatives (NB-02 and NE-02) were compared to that of the parent compound. Indomethacin derivatives (NB-02, NP-02 and NE-02) exhibited significant (P < 0.01) anti-inflammatory activity as observed in carrageenan induced rat paw inflammatory model. The severity of gastric lesion were also significantly (P < 0.01) less in animals treated with ester derivatives of indomethacin (NB-02, NP-02 and NE-02) as compared to mo-control.
authors.affiliation: Maharaja Surajmal Institute of Pharmacy, Janakpuri, New Delhi. neelam_vashist2003@yahoo.co.in
authors.forename: Neelam
authors.initials: N
authors.lastname: Vashist
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: D P
authors.initials: DP
authors.lastname: Pathak
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D007213:Indomethacin / Q000031:analogs & derivatives*; D008297:Male; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D020030:Nitric Oxide Donors; D007213:Indomethacin