title: [Pharmacourodynamic non-invasive studies in patients with prostatic adenoma].
abstract: After examination 47 patients with prostatic adenoma (mean age 63 years) received a course of alpha1-adenoblocker (omsulosin in a dose 0.4 mg/day). A three-day uroflowmetric monitoring was made at home before and after treatment. The findings were assessed with Liverpool nomo-gram by maximal flow. Omsulosin treatment was found to change voiding structure, to identify the obstructive component due to displacement of the flow characteristics to the low centiles of the nomogram. Thus, long-term treatment with alpha1-adrenoblockers can be used as a pharmacourodynamic test to detect infravesical obstruction in patients with prostatic adenoma.
authors.forename: V V
authors.initials: VV
authors.lastname: Danilov
authors.forename: A V
authors.initials: AV
authors.lastname: Vasil'chenko
authors.forename: T I
authors.initials: TI
authors.lastname: Danilova
authors.forename: S A
authors.initials: SA
authors.lastname: Besedin
authors.forename: S A
authors.initials: SA
authors.lastname: Borshchenko
authors.forename: V V
authors.initials: VV
authors.lastname: Danilov
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D013449:Sulfonamides / Q000008:administration & dosage / Q000627:therapeutic use; D000077409:Tamsulosin; D016896:Treatment Outcome; D014463:Ultrasonography; D001748:Urinary Bladder Neck Obstruction / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D014563:Urodynamics / Q000187:drug effects*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin