title: Synthesis and determination of acute and chronic pain activities of 1-[1-(4-methylphenyl) (cyclohexyl)] morpholine as a new phencyclidine derivative in rats.
abstract: Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 77-10-1, PCP, I) and many of its analogues have been synthesized and their pharmacological properties studied. In this research, new methyl morpholine derivative of phencyclidine (1-[1-(4-methylphenyl) (cyclohexyl)]morpholine, Methyl-PCM, III) was synthesized and the acute and chronic pain activities were studied using tail immersion and formalin tests on rats and compared to PCP and PCM (1-(1-phenylcyclohexyl)morpholine, CAS 2201-40-3, PCP-morpholine, II). The results Indicated that Methyl-PCM (III, 6 mg/kg, i.p) produces more analgesic effects in tail immersion test (as a model of acute thermal pain) in comparison with the PCP, PCM and control groups. Meanwhile, this analgesic effect was markedly shown 5-15 min after the compound III application. In formalin test analysis, the acute pain (phase I) could not be affected by any drugs, but the chronic formalin pain (phase II) could be diminished by PCM and especially compound III. The chronic analgesic effect of Methyl-PCM was markedly shown in the late phase of chronic pain.
authors.affiliation: Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj branch, Karaj, Iran. a-ahmadi@kiau.ac.ir
authors.forename: Abbas
authors.initials: A
authors.lastname: Ahmadi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Khalili
authors.forename: Ramin
authors.initials: R
authors.lastname: Hajikhani
authors.forename: Moslem
authors.initials: M
authors.lastname: Naserbakht
mesh_terms: D000208:Acute Disease; D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D002908:Chronic Disease; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis / Q000494:pharmacology*; D005260:Female; D005557:Formaldehyde; D007101:Immersion; D007202:Indicators and Reagents; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats
chemical_list: C557686:1-(1-(4-methylphenyl) (cyclohexyl)) morpholine; D018712:Analgesics, Non-Narcotic; D018691:Excitatory Amino Acid Antagonists; D007202:Indicators and Reagents; D009025:Morpholines; D005557:Formaldehyde; D010622:Phencyclidine