title: Role of prothrombotic polymorphisms in successful or unsuccessful aging.
abstract: The study of the genetic profile of centenarians aims to identify the genes and allelic variants which may influence a greater life expectancy and that can be considered as predisposing factors associated to the aging diseases, such as Alzheimer. Centenarians, that represent a cohort of selected survivors, show an hypercoagulability state characterised by striking signs of high coagulation enzyme activity, as directly assessed by the tested higher plasma level of some important factors involved in the haemostasis balance. Anyway, these individuals seem to have a reduced susceptibility to dementia, as well as to cardiovascular events. In this study we analyze the frequencies of Leiden Factor V polymorphism (G1691A), and G20210A of prothrombin (FII) in three cohorts of subjects: patients with Alzheimer's disease (unsuccessful aging), nonagenarians (successful aging) and young healthy controls, to assess whether allelic variants associated to the modification of haemostatic system function, may play a role in the protection or susceptibility to Alzheimer disease, as well as to reach a successful aging. No significant differences were observed in the frequencies of the three groups studied. These results indicate that the presence or absence of the gene variants examined did not influence the achievement of advanced age and are not risk factors for Alzheimer's disease. The state of hypercoagulability and the possession of these risk alleles appear to be compatible with the achievement of longevity and are not implied as risk factors in Alzheimer disease development.
authors.affiliation: Department of Biopathology, University of Palermo, Corso Tukory 211, 90134, Palermo, Italy.
authors.forename: Loredana
authors.initials: L
authors.lastname: Vaccarino
authors.forename: Giusi Irma
authors.initials: GI
authors.lastname: Forte
authors.forename: Marisa
authors.initials: M
authors.lastname: Palmeri
authors.forename: Gabriella
authors.initials: G
authors.lastname: Misiano
authors.forename: Elisa
authors.initials: E
authors.lastname: Porcellini
authors.forename: Martina
authors.initials: M
authors.lastname: Chiappelli
authors.forename: Letizia
authors.initials: L
authors.lastname: Scola
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
authors.forename: Federico
authors.initials: F
authors.lastname: Licastro
authors.forename: Domenico
authors.initials: D
authors.lastname: Lio
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics*; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin