title: Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand-Nanoparticle Distributions.
abstract: Partial acetylation of the amine-terminated poly(amidoamine) dendrimer has been used in the preparation of dendrimer particles conjugated with a wide variety of functional ligands including targeting moieties, therapeutic agents, and dye molecules. The effectiveness of mass transport during the partial acetylation reaction was found to have a major effect on subsequent distributions of dendrimer-ligand components and to be a major source of inconsistency between batches. This study has broad implications for a wide range of nanoparticle-ligand systems because it demonstrates that conjugates with the same mean ligand-particle ratios can have completely different distribution profiles.
authors.affiliation: Program in Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109.
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Mullen
authors.forename: Emilee L
authors.initials: EL
authors.lastname: Borgmeier
authors.forename: Ming
authors.initials: M
authors.lastname: Fang
authors.forename: Daniel Q
authors.initials: DQ
authors.lastname: McNerny
authors.forename: Ankur
authors.initials: A
authors.lastname: Desai
authors.forename: James R
authors.initials: JR
authors.lastname: Baker
authors.forename: Bradford G
authors.initials: BG
authors.lastname: Orr
authors.forename: Mark M Banaszak
authors.initials: MM
authors.lastname: Holl