title: Nisin and class IIa bacteriocin resistance among Listeria and other foodborne pathogens and spoilage bacteria.
abstract: Food safety has been an important issue globally due to increasing foodborne diseases and change in food habits. To inactivate foodborne pathogens, various novel technologies such as biopreservation systems have been studied. Bacteriocins are ribosomally synthesized peptides or proteins with antimicrobial activity produced by different groups of bacteria, but the bacteriocins produced by many lactic acid bacteria offer potential applications in food preservation. The use of bacteriocins in the food industry can help reduce the addition of chemical preservatives as well as the intensity of heat treatments, resulting in foods that are more naturally preserved. However, the development of highly tolerant and/or resistant strains may decrease the efficiency of bacteriocins as biopreservatives. Several mechanisms of bacteriocin resistance development have been proposed among various foodborne pathogens. The acquiring of resistance to bacteriocins can significantly affect physiological activity profile of bacteria, alter cell-envelope lipid composition, and also modify the antibiotic susceptibility/resistance profile of bacteria. This article presents a brief review on the scientific research about the various possible mechanisms involved in the development of resistance to nisin and Class IIa bacteriocins among the foodborne pathogens.
authors.affiliation: Microbial Metabolites Laboratory, Dairy Microbiology Division, National Dairy Research Institute, Karnal, India.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kaur
authors.forename: Ravinder Kumar
authors.initials: RK
authors.lastname: Malik
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Mishra
authors.forename: Tejinder Pal
authors.initials: TP
authors.lastname: Singh
authors.forename: Arun
authors.initials: A
authors.lastname: Bhardwaj
authors.forename: Garima
authors.initials: G
authors.lastname: Singroha
authors.forename: Shilpa
authors.initials: S
authors.lastname: Vij
authors.forename: Naresh
authors.initials: N
authors.lastname: Kumar
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001430:Bacteriocins / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics; D005516:Food Microbiology; D005519:Food Preservation / Q000379:methods; D005517:Foodborne Diseases / Q000382:microbiology / Q000517:prevention & control*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008089:Listeria monocytogenes / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D008088:Listeriosis / Q000382:microbiology / Q000517:prevention & control*; D010743:Phospholipids / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D006023:Glycoproteins; D010743:Phospholipids