title: Carbon monoxide: a gas that modulates nociception.
abstract: Carbon monoxide (CO) has been recognized to act as an atypical neurotransmitter or neuromodulator in the nervous system and to be involved in a wide variety of neuronal activities. Several lines of evidence suggest that CO may play a role through multiple mechanisms in nociception processing. Differential regulation of a family of CO-generating enzymes, heme oxygenase (HO), contributes mainly to the complexity underlying the role of CO in nociception. This Mini-Review describes the latest evidence for the role of CO during normal sensory transmission and pathological pain conditions and discusses potential cellular mechanisms by which CO is involved in pathological pain.
authors.affiliation: Department of Oral Anatomy and Physiology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Wenguo
authors.initials: W
authors.lastname: Fan
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wu
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhu
authors.forename: Dongpei
authors.initials: D
authors.lastname: Li
authors.forename: Hongwen
authors.initials: H
authors.lastname: He
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D010146:Pain / Q000188:drug therapy / Q000378:metabolism*; D058748:Pain Perception / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D009569:Nitric Oxide; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing)