title: Mediastinal growing teratoma syndrome successfully treated by multiple modality therapies.
abstract: A 43-year-old-man was diagnosed as having primary mediastinal nonseminomatous germ cell tumor based on percutaneous biopsy and an elevated serum concentration of alpha-fetoprotein (AFP). Although AFP decreased after chemotherapy, the mass size grew and developed tracheal compression by the tumor. The patient was treated with mechanical ventilation and subsequent stent implantation for keeping airway patency. After three cycles of chemotherapy and normalization of AFP, the increased mass was successfully resected and the pathological examination demonstrated a mature teratoma. This case showed a rare clinical manifestation of mediastinal growing teratoma syndrome and successful outcome by multimodal therapies.
authors.affiliation: The First Department of Internal Medicine, Shinshu University School of Medicine, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Agatsuma
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
authors.forename: Gaku
authors.initials: G
authors.lastname: Saito
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kondo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yoshida
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Ito
authors.forename: Maki
authors.initials: M
authors.lastname: Endo
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shimojo
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D012121:Respiration, Artificial / Q000379:methods; D013577:Syndrome; D013724:Teratoma / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents