title: Effect of a probiotic intake on oxidant and antioxidant parameters in plasma of athletes during intense exercise training.
abstract: The aim of this study was to evaluate the effect of Lactobacillus rhamnosus IMC 501 and Lactobacillus paracasei IMC 502 on oxidative stress in athletes during a four-week period of intense physical activity. Two groups of twelve subjects each were selected for this analysis. The first group consumed a daily dose of a mixture of the two probiotic strains (1:1 L. rhamnosus IMC 501 and L. paracasei IMC 502; ~10(9) cells/day) for 4 weeks. The second group (control) did not consume any supplements during the 4 weeks. Blood samples collected immediately before and after the supplementation were analyzed, and plasma levels of reactive oxygen metabolites and biological antioxidant potential were determined. Faeces were also collected and analyzed before and at the end of the probiotic supplementation. Antioxidative activity and oxidative stress resistance of the two strains were determined in vitro. Results demonstrated that intense physical activity induced oxidative stress and that probiotic supplementation increased plasma antioxidant levels, thus neutralizing reactive oxygen species. The two strains, L. rhamnosus IMC 501(®) and L. paracasei IMC 502(®), exert strong antioxidant activity. Athletes and all those exposed to oxidative stress may benefit from the ability of these probiotics to increase antioxidant levels and neutralize the effects of reactive oxygen species.
authors.affiliation: School of Pharmacy, Unit of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle carceri 9, 62032 Camerino, MC, Italy. daniele.martarelli@unicam.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Martarelli
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Verdenelli
authors.forename: Stefania
authors.initials: S
authors.lastname: Scuri
authors.forename: Mario
authors.initials: M
authors.lastname: Cocchioni
authors.forename: Stefania
authors.initials: S
authors.lastname: Silvi
authors.forename: Cinzia
authors.initials: C
authors.lastname: Cecchini
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Pompei
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D056352:Athletes; D019587:Dietary Supplements / Q000032:analysis; D015444:Exercise; D006801:Humans; D007778:Lactobacillus; D052201:Lacticaseibacillus rhamnosus; D008297:Male; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D019936:Probiotics / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D016877:Oxidants