title: [Progress in the study of UDP-glucuronosyltransferase gene polymorphism].
abstract: Uridinediphosphoglucuronate-glucuronosyltransferase (UGT) is the most important enzyme of the body in phase II metabolism. UGT is widely distributed in multiple tissues, including liver, kidney and intestine, which metabolizes a large number of exogenous toxic substances and endogenous substances. Studies found that UGT1 A genetic polymorphism is one of the important reasons for the variability of glucuronic acid metabolism between individuals. This paper reviews the current concept and new advances on UGT gene mutation.
authors.affiliation: Institute of Clinical Pharmacology, Xiang-Ya Medical College, Central South University, Changsha 410078, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Guo
authors.forename: Liang-Fang
authors.initials: LF
authors.lastname: Pang
authors.forename: Hong-Hao
authors.initials: HH
authors.lastname: Zhou
mesh_terms: D000818:Animals; D020723:Glucuronic Acid / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic
chemical_list: D020723:Glucuronic Acid; D014453:Glucuronosyltransferase