title: Heart failure resulting from giant left atrial synovial sarcoma metastasis.
abstract: Synovial sarcoma metastasis affecting the heart and infiltrating the mitral valve is a very rare pathology. We report the case of a 44-year-old male treated with chemotherapy for atypical synovial sarcoma of the oral mucosa who presented to our clinic after cardiac decompensation with a presumptive diagnosis of myxoma of the left atrium. A large necrotic tumour positive for CK 22, EMA, CD 99 and BCL-2 but negative for translocation in COBRA-FISH analysis by break-apart probe could be excised and revealed a very rare subtype of synovial sarcoma metastasis arising from the endocard of the left atrium. The tumour was resected and the mitral valve reconstructed through ring annuloplasty.
authors.affiliation: Cardiac Surgery Basel, University Hospital Basel, Heart Surgery Centre Basel-Bern, Basel, Switzerland. bwinkler@uhbs.ch
authors.forename: B
authors.initials: B
authors.lastname: Winkler
authors.forename: M
authors.initials: M
authors.lastname: Grapow
authors.forename: M
authors.initials: M
authors.lastname: Seeberger
authors.forename: P
authors.initials: P
authors.lastname: Matt
authors.forename: W
authors.initials: W
authors.lastname: Aulitzky
authors.forename: F
authors.initials: F
authors.lastname: Eckstein
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D017548:Echocardiography, Transesophageal; D006325:Heart Atria / Q000473:pathology; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006338:Heart Neoplasms / Q000737:chemistry / Q000150:complications* / Q000235:genetics / Q000556:secondary* / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D058386:Mitral Valve Annuloplasty; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D013584:Sarcoma, Synovial / Q000737:chemistry / Q000150:complications* / Q000235:genetics / Q000556:secondary* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor