title: Preparation of molecularly imprinted polymers for the selective recognition of the bioactive polyphenol, (E)-resveratrol.
abstract: (E)-Resveratrol imprinted polymers have been rationally designed with the aid of molecular modelling and NMR spectroscopic titration techniques to determine the optimal ratio of the template to functional monomer for polymer formation. Based on this approach, (E)-resveratrol imprinted polymers were prepared via non-covalent self-assembly with the functional monomer 4-vinylpyridine (4VP) in a 1:3 molar ratio. Polymerisation in the presence of a cross-linker resulted in rigid block copolymers that had selective capacities towards (E)-resveratrol (e.g. 14 μmol/g) when compared to the non-imprinted reference polymer. The selectivity of these MIPs was also examined using several structurally related polyphenolic compounds to determine the influence of polyphenolic hydroxyl number and position on binding and molecular recognition.
authors.affiliation: Centre for Green Chemistry, Monash University, Clayton, 3800 Vic, Australia.
authors.forename: Lachlan J
authors.initials: LJ
authors.lastname: Schwarz
authors.forename: Basil
authors.initials: B
authors.lastname: Danylec
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Harris
authors.forename: Reinhard I
authors.initials: RI
authors.lastname: Boysen
authors.forename: Milton T W
authors.initials: MT
authors.lastname: Hearn
mesh_terms: D002851:Chromatography, High Pressure Liquid; D008958:Models, Molecular; D054802:Molecular Imprinting; D010636:Phenols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011725:Pyridines; D000077185:Resveratrol; D052616:Solid Phase Extraction; D013267:Stilbenes / Q000737:chemistry*
chemical_list: D010636:Phenols; D011108:Polymers; D011725:Pyridines; D013267:Stilbenes; C029351:4-vinylpyridine; D000077185:Resveratrol