title: Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-Baylis-Hillman reaction.
abstract: A highly chemoselective PPh(3)-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.
authors.forename: Siang-en
authors.initials: SE
authors.lastname: Syu
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Lee
authors.forename: Yeong-Jiunn
authors.initials: YJ
authors.lastname: Jang
authors.forename: Wenwei
authors.initials: W
authors.lastname: Lin