title: Direct T2 quantification of myocardial edema in acute ischemic injury.
abstract: OBJECTIVE
  To evaluate the utility of rapid, quantitative T2 mapping compared with conventional T2-weighted imaging in patients presenting with various forms of acute myocardial infarction.
  
  
  BACKGROUND
  T2-weighted cardiac magnetic resonance (CMR) identifies myocardial edema before the onset of irreversible ischemic injury and has shown value in risk-stratifying patients with chest pain. Clinical acceptance of T2-weighted CMR has, however, been limited by well-known technical problems associated with existing techniques. T2 quantification has recently been shown to overcome these problems; we hypothesized that T2 measurement in infarcted myocardium versus remote regions versus zones of microvascular obstruction in acute myocardial infarction patients could help reduce uncertainty in interpretation of T2-weighted images.
  
  
  METHODS
  T2 values using a novel mapping technique were prospectively recorded in 16 myocardial segments in 27 patients admitted with acute myocardial infarction. Regional T2 values were averaged in the infarct zone and remote myocardium, both defined by a reviewer blinded to the results of T2 mapping. Myocardial T2 was also measured in a group of 21 healthy volunteers.
  
  
  RESULTS
  T2 of the infarct zone was 69 ± 6 ms compared with 56 ± 3.4 ms for remote myocardium (p < 0.0001). No difference in T2 was observed between remote myocardium and myocardium of healthy volunteers (56 ± 3.4 ms and 55.5 ± 2.3 ms, respectively, p = NS). T2 mapping allowed for the detection of edematous myocardium in 26 of 27 patients; by comparison, segmented breath-hold T2-weighted short tau inversion recovery images were negative in 7 and uninterpretable in another 2 due to breathing artifacts. Within the infarct zone, areas of microvascular obstruction were characterized by a lower T2 value (59 ± 6 ms) compared with areas with no microvascular obstruction (71.6 ± 10 ms, p < 0.0001). T2 mapping provided consistent high-quality results in patients unable to breath-hold and in those with irregular heart rhythms, in whom short tau inversion recovery often yielded inadequate imaging.
  
  
  CONCLUSIONS
  Quantitative T2 mapping reliably identifies myocardial edema without the limitations encountered by T2-weighted short tau inversion recovery imaging, and may therefore be clinically more robust in showing acute ischemic injury.
authors.affiliation: The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: David
authors.initials: D
authors.lastname: Verhaert
authors.forename: Paaladinesh
authors.initials: P
authors.lastname: Thavendiranathan
authors.forename: Shivraman
authors.initials: S
authors.lastname: Giri
authors.forename: Georgeta
authors.initials: G
authors.lastname: Mihai
authors.forename: Sanjay
authors.initials: S
authors.lastname: Rajagopalan
authors.forename: Orlando P
authors.initials: OP
authors.lastname: Simonetti
authors.forename: Subha V
authors.initials: SV
authors.lastname: Raman
mesh_terms: D000208:Acute Disease; D000368:Aged; D016022:Case-Control Studies; D004487:Edema / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D015588:Observer Variation; D009820:Ohio; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D013318:Stroke Volume; D016277:Ventricular Function, Left