title: [Determination of liver triglycerides by 1H MR spectroscopy].
abstract: BACKGROUND
  Metabolic syndrome is responsible for increasing the fat content of the liver. Among several non-invasive methods of liver fat analysis, the most important role is played by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). This pilot study describes the methodology for measurements of triglycerides in the liver in a group of liver transplant patients using 1H MRS at 3T.
  
  
  RESULTS
  Thirty-eight patients (12 Female, 27 male, aged 19-71) who underwent routine preventive examination at IKEM were included in the MRS study. The fat content of liver biopsies was classified according to the number of affected hepatocytes, HIS. Based on this classification, there were 20 patients with a steatosis score of S0, 15 patients with a score of S1, 2 patients with a score of S2 and 1 patient with a score of S3. 1H MR spectra were measured from three positions in the liver. Following Longo et al, the concentration of fat phi(fat), was calculated from the signal intensities of water and triglycerides. Linear correlation between the number of affected hepatocytes and fat content was described by the equation: HIS = 6.4 phi(fat) -2.1; r2 = 0.85; p = 0.001.
  
  
  CONCLUSIONS
  The pilot study confirmed that examination of fat content using 1H MRS at 3T is well tolerated by patients. Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content. The method is suitable for non-invasive repetitive and screening examination measurement of fat in the liver.
authors.affiliation: Institut klinické a experimentální medicíny Praha, MR spektroskopie, Základna radiodiagnostiky a intervencní radiologie. miha@medicon.cz
authors.forename: Milan
authors.initials: M
authors.lastname: Hájek
authors.forename: Monika
authors.initials: M
authors.lastname: Dezortová
authors.forename: Dita
authors.initials: D
authors.lastname: Wagnerová
authors.forename: Ludek
authors.initials: L
authors.lastname: Voska
authors.forename: Irena
authors.initials: I
authors.lastname: Hejlová
authors.forename: Pavel
authors.initials: P
authors.lastname: Trunecka
mesh_terms: D000328:Adult; D000368:Aged; D005234:Fatty Liver / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000032:analysis*; D055815:Young Adult
chemical_list: D014280:Triglycerides