title: Diagnostic value of sonazoid for hepatic metastasis: comparison with FDG PET/CT.
abstract: OBJECTIVE
  This study was conducted to evaluate the diagnostic efficacy of contrast enhanced ultrasonography (CEUS) with perflubutane (Sonazoid) for hepatic metastasis and compared it with that of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) computed tomography (CT).
  
  
  METHODS
  From January 2007 to July 2009, 109 Japanese patients with gastrointestinal tract cancer were enrolled, of whom 4 had esophageal cancer, 28 gastric cancer, 1 duodenal cancer, and 76 colorectal cancer. After a bolus injection with Sonazoid (0.5 ml/body), the liver was scanned in both arterial and Kupffer phases. The results of PET/CT and other abdominal imaging examinations were not shown to the CEUS operators. We compared diagnostic efficacy between CEUS and PET/CT.
  
  
  RESULTS
  Average values for age, body mass index, and maximum diameter of the hepatic metastasis were 68.7 +/- 11.0 years, 21.2 +/- 4.2, and 29.2 +/- 20.5mm, respectively. Hepatic metastasis were suspected in 31 patients based on PET/CT findings and 32 by CEUS. Finally, hepatic metastasis was diagnosed in 30 patients. The sensitivity, specificity, and accuracy rates for CEUS and PET/CT were similar (100% vs. 100%, 97.5% vs. 98.7%, and 95.5% vs. 93.6%, respectively).
  
  
  CONCLUSIONS
  CEUS had a diagnostic value similar to that of PET/CT for hepatic metastasis.
authors.affiliation: Gastroenterology Center, Ehime Prefectural Central Hospital, Ehime, Japan. hirage@m.ehime-u.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hiraoka
authors.forename: Misaki
authors.initials: M
authors.lastname: Kume
authors.forename: Masao
authors.initials: M
authors.lastname: Miyagawa
authors.forename: Nayu
authors.initials: N
authors.lastname: Tazuya
authors.forename: Misa
authors.initials: M
authors.lastname: Ichiryu
authors.forename: Hironori
authors.initials: H
authors.lastname: Ochi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanabe
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Nakahara
authors.forename: Yuki
authors.initials: Y
authors.lastname: Shinbata
authors.forename: Miki
authors.initials: M
authors.lastname: Kan
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Doi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hidaka
authors.forename: Takahide
authors.initials: T
authors.lastname: Uehara
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tanihira
authors.forename: Aki
authors.initials: A
authors.lastname: Hasebe
authors.forename: Yasunao
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ninomiya
authors.forename: Masashi
authors.initials: M
authors.lastname: Hirooka
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Bunzo
authors.initials: B
authors.lastname: Matsuura
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
mesh_terms: D000368:Aged; D003287:Contrast Media; D005290:Ferric Compounds; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement; D007501:Iron; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary*; D008875:Middle Aged; D010087:Oxides; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D019788:Fluorodeoxyglucose F18; D007501:Iron