title: Transmission dynamics and control of cholera in Haiti: an epidemic model.
abstract: BACKGROUND
  Official projections of the cholera epidemic in Haiti have not incorporated existing disease trends or patterns of transmission, and proposed interventions have been debated without comparative estimates of their effect. We used a mathematical model of the epidemic to provide projections of future morbidity and mortality, and to produce comparative estimates of the effects of proposed interventions.
  
  
  METHODS
  We designed mathematical models of cholera transmission based on existing models and fitted them to incidence data reported in Haiti for each province from Oct 31, 2010, to Jan 24, 2011. We then simulated future epidemic trajectories from March 1 to Nov 30, 2011, to estimate the effect of clean water, vaccination, and enhanced antibiotic distribution programmes.
  
  
  RESULTS
  We project 779,000 cases of cholera in Haiti (95% CI 599,000-914,000) and 11,100 deaths (7300-17,400) between March 1 and Nov 30, 2011. We expect that a 1% per week reduction in consumption of contaminated water would avert 105,000 cases (88,000-116,000) and 1500 deaths (1100-2300). We predict that the vaccination of 10% of the population, from March 1, will avert 63,000 cases (48,000-78,000) and 900 deaths (600-1500). The proposed extension of the use of antibiotics to all patients with severe dehydration and half of patients with moderate dehydration is expected to avert 9000 cases (8000-10,000) and 1300 deaths (900-2000).
  
  
  CONCLUSIONS
  A decline in cholera prevalence in early 2011 is part of the natural course of the epidemic, and should not be interpreted as indicative of successful intervention. Substantially more cases of cholera are expected than official estimates used for resource allocation. Combined, clean water provision, vaccination, and expanded access to antibiotics might avert thousands of deaths.
  
  
  BACKGROUND
  National Institutes of Health.
authors.affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. jandrews6@partners.org
authors.forename: Jason R
authors.initials: JR
authors.lastname: Andrews
authors.forename: Sanjay
authors.initials: S
authors.lastname: Basu
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002771:Cholera / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control* / Q000635:transmission; D022121:Cholera Vaccines / Q000008:administration & dosage*; D003198:Computer Simulation; D003681:Dehydration / Q000453:epidemiology / Q000209:etiology; D004196:Disease Outbreaks / Q000517:prevention & control*; D006205:Haiti / Q000453:epidemiology; D006295:Health Resources; D006301:Health Services Needs and Demand; D006801:Humans; D015994:Incidence; D008432:Mathematical Computing; D015233:Models, Statistical; D015995:Prevalence; D012720:Severity of Illness Index; D014480:United Nations; D014871:Water Microbiology; D014881:Water Supply / Q000592:standards
chemical_list: D000900:Anti-Bacterial Agents; D022121:Cholera Vaccines