title: Hypoxia and adipose-derived stem cell-based tissue regeneration and engineering.
abstract: BACKGROUND
  Realization that oxygen is one of the key regulators of development and differentiation has a profound significance on how current cell-based and tissue engineering applications using adipose-derived stem cells (ASCs) can be further improved.
  
  
  METHODS
  The article provides an overview of mechanisms of hypoxic responses during physiological adaptations and development. Furthermore, a synopsis of the hypoxic responses of ASCs is provided, and this information is presented in context of their utility as a major source of stem cells across the regenerative applications explored to date.
  
  
  CONCLUSIONS
  The reader will obtain insight into a highly specific area of stem cell research focusing on ASCs and hypoxia. In order to enhance the level of comprehension, a broader context with other stem cell and experimental systems is provided. It is emphasized that the pericellular oxygen tension is a critical regulatory factor that should be taken into account when devising novel stem cell-based therapeutic applications along with other parameters, such as biochemical soluble factors and the growth substrates.
authors.affiliation: Aalborg University, Laboratory for Stem Cell Research, Fredrik Bajers Vej 3B, 9220 Aalborg, Denmark. vlaz@hst.aau.dk
authors.forename: Vladimir
authors.initials: V
authors.lastname: Zachar
authors.forename: Meg
authors.initials: M
authors.lastname: Duroux
authors.forename: Jeppe
authors.initials: J
authors.lastname: Emmersen
authors.forename: Jeppe G
authors.initials: JG
authors.lastname: Rasmussen
authors.forename: Cristian P
authors.initials: CP
authors.lastname: Pennisi
authors.forename: Sufang
authors.initials: S
authors.lastname: Yang
authors.forename: Trine
authors.initials: T
authors.lastname: Fink
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D006706:Homeostasis; D006801:Humans; D010100:Oxygen / Q000378:metabolism; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering
chemical_list: D010100:Oxygen