title: Curvature-driven lipid sorting in biomembranes.
abstract: It has often been suggested that the high curvature of transport intermediates in cells may be a sufficient means to segregate different lipid populations based on the relative energy costs of forming bent membranes. In this review, we present in vitro experiments that highlight the essential physics of lipid sorting at thermal equilibrium: It is driven by a trade-off between bending energy, mixing entropy, and interactions between species. We collect evidence that lipid sorting depends strongly on lipid-lipid and protein-lipid interactions, and hence on the underlying composition of the membrane and on the presence of bound proteins.
authors.affiliation: CNRS UMR 5207, Laboratoire de Physique Théorique et Astroparticules, Université Montpellier II, 34095 Montpellier Cedex 05, France.
authors.forename: Andrew
authors.initials: A
authors.lastname: Callan-Jones
authors.forename: Benoit
authors.initials: B
authors.lastname: Sorre
authors.forename: Patricia
authors.initials: P
authors.lastname: Bassereau
mesh_terms: D001692:Biological Transport / Q000502:physiology; D001703:Biophysics; D002462:Cell Membrane / Q000737:chemistry* / Q000648:ultrastructure; D019277:Entropy; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D008563:Membrane Lipids; D008565:Membrane Proteins