title: Antioxidant effect of Lagerstroemia speciosa Pers (banaba) leaf extract in streptozotocin-induced diabetic mice.
abstract: Aqueous leaf extract of L. speciosa (banaba) effectively decreased the blood glucose in streptozotocin-induced diabetic mice after 15th day of banaba exposure. Further, banaba leaf extract have the potential to inhibit lipid peroxidation and effectively intercept/neutralize reactive oxygen species such as super oxide, H2O2 and NO based free radicals. The aqueous banaba leaf extract (150 mg/kg bodyweight) duly reduced STZ generated reactive intermediates and radical species helping to regulate normal levels of antioxidative markers like superoxide dismutase, catalase, glutathione-S-transferase and reduced glutathione.
authors.affiliation: Department of Zoology, Bangalore University, Bangalore 560 056, India.
authors.forename: S M
authors.initials: SM
authors.lastname: Saumya
authors.forename: P Mahaboob
authors.initials: PM
authors.lastname: Basha
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006861:Hydrogen Peroxide / Q000378:metabolism; D031563:Lagerstroemia; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013311:Streptozocin; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D013481:Superoxides; D009569:Nitric Oxide; D013311:Streptozocin; D006861:Hydrogen Peroxide