title: Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals.
abstract: The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1(+)/Bw4(+) inhibitory complex was reduced, whereas that of the activatory KIR3DS1(+) ligand and the activatory Bw4(+)/3DL1(-)/3DS1(+) complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.
authors.affiliation: Fondazione Don C. Gnocchi, IRCCS, Pavia, Italy.
authors.forename: Franca Rosa
authors.initials: FR
authors.lastname: Guerini
authors.forename: Sergio
authors.initials: S
authors.lastname: Lo Caputo
authors.forename: Andrea
authors.initials: A
authors.lastname: Gori
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bandera
authors.forename: Francesco
authors.initials: F
authors.lastname: Mazzotta
authors.forename: Alessia
authors.initials: A
authors.lastname: Uglietti
authors.forename: Milena
authors.initials: M
authors.lastname: Zanzottera
authors.forename: Renato
authors.initials: R
authors.lastname: Maserati
authors.forename: Mario
authors.initials: M
authors.lastname: Clerici
mesh_terms: D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D054341:Receptors, KIR3DL1 / Q000235:genetics*
chemical_list: D015235:HLA-B Antigens; D015236:HLA-C Antigens; C515083:KIR3DL1 protein, human; D054341:Receptors, KIR3DL1