title: Effects of thoracic and fine PM and their components on heart rate and pulmonary function in COPD patients.
abstract: Population-based personal exposures to particulate matter (PM) and personal-ambient relationships of PM and component concentrations for outpatients with COPD and/or asthma were investigated in New York City (NYC) and Seattle for thoracic PM (PM(10)) and fine PM (PM(2.5)). Measurements of outdoor, indoor, and personal PM(10) and PM(2.5) concentrations were made concurrently for 12-consecutive days at 24 patients' residences. Filters were analyzed for elemental components, using XRF and black carbon (BC), by reflectance. Daily morning and evening measurements of heart rate (HR) and blood oxygen saturation (SpO(2)) by pulse oximeter, and forced expiratory volume in 1 s (FEV(1)) and peak expiratory flowrate (PEF) by spirometry were also measured, and symptom data were collected. Central monitoring site, outdoor, indoor, and personal concentration-response relationships of PM(2.5), PM(10-2.5), and their components were examined using mixed-effect models. The relatively small sample size of the study limited the interpretation of results, but of the PM chemical components examined, only nickel concentrations showed consistent associations, and only with HR in the NYC COPD patients.
authors.affiliation: Columbia University, School of Public Health, New York, NY 10987, USA.
authors.forename: Sha O-I
authors.initials: SO
authors.lastname: Hsu
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ito
authors.forename: Morton
authors.initials: M
authors.lastname: Lippmann
mesh_terms: D000368:Aged; D000393:Air Pollutants / Q000032:analysis*; D001249:Asthma / Q000453:epidemiology / Q000209:etiology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D009519:New York City / Q000453:epidemiology; D010316:Particle Size; D052638:Particulate Matter / Q000633:toxicity*; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000209:etiology*; D012129:Respiratory Function Tests; D018570:Risk Assessment; D012621:Seasons; D013997:Time Factors; D014504:Urban Health; D014861:Washington / Q000453:epidemiology
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter