title: Iron and cardiovascular dysfunction: mechanisms and therapeutic implications.
abstract: It has been recognized for over three decades that tissue hypoperfusion is associated with the appearance of increased levels of iron in the plasma. Experimental observations have documented the liberation of iron into the circulation following reperfusion of ischemic myocardium and small intestine, and into the urine following renal ischemia-reperfusion. Similarly, we have recently demonstrated that iron is delocalized during ischemia of skeletal muscle, via a process which persists upon reperfusion. Other studies have demonstrated delocalization of iron in the parenchyma of postischemic brain, myocardium, and kidney.
authors.affiliation: Assistant Professor of Surgery, Cornell University Medical College, Assistant Attending Surgeon (Vascular), The New York Hospital, New York, New York.
authors.forename: G A
authors.initials: GA
authors.lastname: Fantini
authors.forename: R E
authors.initials: RE
authors.lastname: Kirschner