title: Creatine as an antioxidant.
abstract: Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving greater attention because of its beneficial effects in a wide number of human degenerative diseases and conditions. These effects can be barely explained on the basis of the sole ergogenic role of the Cr/CrP system. Indeed, a wide number of research articles indicate that Cr is capable of exerting multiple, non-energy related, effects on diverse and relevant cellular targets. Among these effects, the antioxidant activity of Cr emerges as an additional mechanism which is likely to play a supportive role in the Cr-cytoprotection paradigm.
authors.affiliation: Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Via Saffi 2, Urbino, Italy. piero.sestili@uniurb.it
authors.forename: Piero
authors.initials: P
authors.lastname: Sestili
authors.forename: C
authors.initials: C
authors.lastname: Martinelli
authors.forename: E
authors.initials: E
authors.lastname: Colombo
authors.forename: E
authors.initials: E
authors.lastname: Barbieri
authors.forename: L
authors.initials: L
authors.lastname: Potenza
authors.forename: S
authors.initials: S
authors.lastname: Sartini
authors.forename: C
authors.initials: C
authors.lastname: Fimognari
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D003401:Creatine / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D019587:Dietary Supplements; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D003401:Creatine