title: Mediating roles of adherence attitude and patient education on antidepressant use in patients with depression.
abstract: OBJECTIVE
  The purpose of this study was to examine the roles of adherence attitude to antidepressants and patient education as mediators in mediating patients' attitudes toward antidepressant use.
  
  
  METHODS
  A sample of 201 outpatients, 50 years of age or older, with major depressive disorder, completed a drug use questionnaire, attitudes toward and patient education about antidepressants questionnaire, and Adherence Attitude Inventory.
  
  
  RESULTS
  Attitudes toward antidepressants were positively associated to antidepressant use, an association explained by the mediating variable, patient education about antidepressants. Adherence attitudes to antidepressants were a mediator that accounted to a significant degree for the causal relationship between attitudes toward antidepressants and antidepressant use.
  
  
  CONCLUSIONS
  Adequate patient education and an understanding of patients' adherence attitude to antidepressant use are needed in nursing practice to reduce patients' uncertainty about treatment and increase successful treatment.
authors.affiliation: Graduate Institute of Clinical Medicine, National Cheng Kung University, Department of Anaesthesiology, Yuli Veterans Hospital, Hualien, Taiwan.
authors.forename: Gwo-Ching
authors.initials: GC
authors.lastname: Sun
authors.forename: Mei-Chi
authors.initials: MC
authors.lastname: Hsu
authors.forename: Wendy
authors.initials: W
authors.lastname: Moyle
authors.forename: Mei-Feng
authors.initials: MF
authors.lastname: Lin
authors.forename: Debra
authors.initials: D
authors.lastname: Creedy
authors.forename: Lorraine
authors.initials: L
authors.lastname: Venturato
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000451:nursing; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D008960:Models, Psychological; D015999:Multivariate Analysis; D010353:Patient Education as Topic; D013624:Taiwan
chemical_list: D000928:Antidepressive Agents