title: Prognostic factors and survival analysis of antimitochondrial antibody-positive primary biliary cirrhosis in Chinese patients.
abstract: OBJECTIVE
  Primary biliary cirrhosis (PBC) is a relatively uncommon liver disease, and information on the prognosis and survival of PBC patients in mainland China is lacking. We therefore conducted a retrospective study to investigate the prognostic factors and survival in Chinese PBC patients.
  
  
  METHODS
  Between October 2001 and May 2009, patients registered at Beijing You'an Hospital with abnormal liver function and serum positivity for antimitochondrial antibody (AMA) and/or AMA-M2 (n = 391) were screened. Patients diagnosed with PBC were identified, and their medical data were reviewed and analyzed for mortality predictors.
  
  
  RESULTS
  A total of 147 PBC patients were identified (mean age: 54 years, range: 28-81), of whom 126 (85.7%) were women. At the time of diagnosis, 119 patients (81.0%) were symptomatic, 28(19.0%) had hepatic decompensation, and no patients were asymptomatic. During a median follow-up period of 48 months (range: 2-312), 36 patients (24.5%) died or underwent liver transplantation, and 65 patients (44.2%) developed hepatic decompensation. The overall 5-year survival rate was 79%. Multivariate analysis indicated that Mayo risk score ≥6.11(P = 0.008), and serum IgG ≥ 17.20 g/l (P = 0.016) were associated with mortality.
  
  
  CONCLUSIONS
  Most Chinese PBC patients in this study were symptomatic at diagnosis and had significant mortality. Mayo risk score, and serum IgG were independent prognostic factors for survival.
authors.affiliation: Clinical Research Center for Autoimmune Liver Disease, Beijing You'an Hospital, Capital Medical University, 100069 Beijing, China. zhaodt2007@yahoo.com.cn
authors.forename: Dan-Tong
authors.initials: DT
authors.lastname: Zhao
authors.forename: Hui-Yu
authors.initials: HY
authors.lastname: Liao
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xia
authors.initials: X
authors.lastname: Feng
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000097:blood* / Q000276:immunology; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000276:immunology / Q000401:mortality* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology*; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000906:Antibodies