title: Development of a dosimetry inter-comparison for IMRT as part of site credentialing for a TROG multi-centre clinical trial for prostate cancer.
abstract: A methodology has been developed for a dosimetry inter-comparison of intensity modulated radiation therapy (IMRT) delivery in Australasia. The inter-comparison is part of site credentialing for those sites participating in the prostate fractionated irradiation trial (PROFIT) for intermediate-risk prostate patients developed by the Ontario Clinical Oncology Group and coordinated in Australasia by the Trans Tasman Radiation Oncology Group. Features of the dosimetry inter-comparison design included the use of a dedicated pelvic anthropomorphic phantom, the use of a single CT data set of the phantom including contours and the use of radiochromic film as a dosimeter. Action levels for agreement between measured dose and treatment planning system dose have been proposed based on measurement uncertainty and international experience. A trial run of the dosimetry procedure at the reference centre gave results within the predefined action levels.
authors.affiliation: Radiation Oncology Queensland, Toowoomba, Australia. brendan.healy@roq.net.au
authors.forename: B
authors.initials: B
authors.lastname: Healy
authors.forename: J
authors.initials: J
authors.lastname: Frantzis
authors.forename: R
authors.initials: R
authors.lastname: Murry
authors.forename: J
authors.initials: J
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Middleton
authors.forename: C
authors.initials: C
authors.lastname: Catton
authors.forename: T
authors.initials: T
authors.lastname: Kron
mesh_terms: D044362:Australasia; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic / Q000379:methods / Q000592:standards; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011874:Radiometry / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D050397:Radiotherapy, Intensity-Modulated / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000592:standards; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed