title: Intradermal vaccination to protect against yellow fever and influenza.
abstract: The viral infections yellow fever and influenza can lead to large epidemics, which may deplete limited vaccine supplies. The intradermal vaccination route of yellow fever and influenza vaccines has received renewed attention, because it allows dose reduction without loss of efficacy. In this chapter, we review these two vaccines, the history of vaccine development, correlates of protection, immune response to vaccination and current knowledge concerning intradermal vaccination, including the immunological background, both in healthy subjects and immunocompromized individuals.
authors.affiliation: Department of Infectious Diseases, Suite C5-P, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
authors.forename: A H E
authors.initials: AH
authors.lastname: Roukens
authors.forename: L B S
authors.initials: LB
authors.lastname: Gelinck
authors.forename: L G
authors.initials: LG
authors.lastname: Visser
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D020405:Dermis / Q000166:cytology / Q000276:immunology*; D005416:Flavivirus / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007109:Immunity; D007115:Immunization Schedule; D016867:Immunocompromised Host; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D007271:Injections, Intradermal; D007801:Langerhans Cells / Q000166:cytology / Q000276:immunology*; D051379:Mice; D014611:Vaccination / Q000379:methods*; D015164:Vaccines, Inactivated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage; D015004:Yellow Fever / Q000276:immunology / Q000517:prevention & control* / Q000821:virology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D014765:Viral Vaccines