title: The caspase pathway as a possible therapeutic target in experimental pemphigus.
abstract: Apoptosis plays a role in pemphigus IgG-dependent acantholysis; theoretically, the blockade of the caspase pathway could prevent the blistering that is caused by pemphigus autoantibodies. Using this strategy, we attempted to block the pathogenic effect of pemphigus IgG in Balb/c mice by using the caspase inhibitor Ac-DEVD-CMK. This inhibitor was administrated before the injection of pemphigus IgG into neonatal mice. The main results of the present investigation are as follows: (1) pemphigus IgG induces intraepidermal blisters in Balb/c neonatal mice; (2) keratinocytes around the blister and acantholytic cells undergo apoptosis; (3) the caspases inhibitor Ac-DEVD-CMK prevents apoptosis; (4) the inhibition of the caspase pathway prevents blister formation. In conclusion, inhibition of the caspase pathway may be a promising therapeutic tool that can help in the treatment of pemphigus flare ups.
authors.affiliation: Departamento de Inmunología, Centro de Biología Experimental, Universidad Autónoma de Zacatecas, Chepinque 306, Col. Lomas de la Soledad, 98040 Zacatecas, ZAC, Mexico.
authors.forename: Deyanira
authors.initials: D
authors.lastname: Pacheco-Tovar
authors.forename: Argelia
authors.initials: A
authors.lastname: López-Luna
authors.forename: Rafael
authors.initials: R
authors.lastname: Herrera-Esparza
authors.forename: Esperanza
authors.initials: E
authors.lastname: Avalos-Díaz