title: Synthesis of organic-inorganic hybrid bicelles-lipid bilayer nanodiscs encompassed by siloxane surfaces.
abstract: Well-defined hybrid nanodiscs were produced by employing bicelle formation of a binary lipid mixture in water. The resulting nanoparticles have a lipid bilayer coated with ceramic layers, which are formed by the sol-gel reaction among the alkoxysilyl headgroups of the hybrid lipid. The hybrid bicelles displayed significant morphological stability against dry environments and surfactant addition, in stark contrast to conventional phospholipid bicelles.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 6300192, Japan. yasuhara@ms.naist.jp
authors.forename: Kazuma
authors.initials: K
authors.lastname: Yasuhara
authors.forename: Shohei
authors.initials: S
authors.lastname: Miki
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakazono
authors.forename: Akio
authors.initials: A
authors.lastname: Ohta
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kikuchi
mesh_terms: D008051:Lipid Bilayers / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012833:Siloxanes / Q000737:chemistry*; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D008051:Lipid Bilayers; D012833:Siloxanes; D013501:Surface-Active Agents; D014867:Water