title: [Effective chemotherapy with S-1 alone in a patient with lung metastases of breast cancer].
abstract: We report a 50-year-old female with pulmonary metastases from breast cancer who responded to S-1. In September 2003, she underwent surgery for breast cancer. Four years 8 months after the operation, lung relapse was detected. After the treatment failure of FEC60 (5-FU 500 mg/m², epirubicin 60 mg/m², cyclophosphamide 500 mg/m²) and taxane antitumor drugs, oral administration of S-1 80 mg/body/day was initiated. At the end of three courses, thoracic CT revealed the disappearance of the lung metastasis. Advanced reactions during the administration period were mild. After 14 courses of S-1 therapy (during 11 months), a complete response was clinically maintained. S-1 showed a good antitumor effect and tolerance, and it might be useful for treating metastatic and recurrent breast cancers.
authors.affiliation: Dept. of Surgery, Itoigawa General Hospital, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tazawa
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Tsuchiya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shinbo
authors.forename: Fuminori
authors.initials: F
authors.lastname: Yamagishi
authors.forename: Katsuo
authors.initials: K
authors.lastname: Shimada
authors.forename: Koshi
authors.initials: K
authors.lastname: Matsui
authors.forename: Takuya
authors.initials: T
authors.lastname: Nagata
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shimada
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsukada
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D010094:Oxonic Acid / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid