title: Viral oncogenesis and its role in nonmelanoma skin cancer.
abstract: In recent years, the contribution of viruses to cutaneous oncogenesis has steadily gained recognition. The archetype is human herpesvirus 8, which is well established as the causative agent in Kaposi sarcoma. Other viruses believed to play a role in nonmelanoma skin cancer include human papillomavirus and the recently described Merkel cell polyomavirus. We review the mechanisms by which these three viruses interact with the host cell, ultraviolet radiation and immunosuppression to result in carcinogenesis.
authors.affiliation: Department of Dermatology, University of California, San Francisco, CA, USA.
authors.forename: S Tuttleton
authors.initials: ST
authors.lastname: Arron
authors.forename: L
authors.initials: L
authors.lastname: Jennings
authors.forename: I
authors.initials: I
authors.lastname: Nindl
authors.forename: F
authors.initials: F
authors.lastname: Rosl
authors.forename: J N
authors.initials: JN
authors.lastname: Bouwes Bavinck
authors.forename: D
authors.initials: D
authors.lastname: Seçkin
authors.forename: M
authors.initials: M
authors.lastname: Trakatelli
authors.forename: G M
authors.initials: GM
authors.lastname: Murphy
mesh_terms: D015266:Carcinoma, Merkel Cell / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000821:virology; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D005544:Forecasting; D019288:Herpesvirus 8, Human; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology; D007165:Immunosuppression Therapy / Q000009:adverse effects; D030361:Papillomavirus Infections / Q000150:complications; D027601:Polyomavirus Infections / Q000150:complications; D012514:Sarcoma, Kaposi / Q000821:virology; D012878:Skin Neoplasms / Q000821:virology*; D014412:Tumor Virus Infections / Q000150:complications*; D014466:Ultraviolet Rays / Q000009:adverse effects