title: A two-step method for estimating QTL effects and positions in multi-marker analysis.
abstract: Quantitative trait is always controlled by multiple latent genetic loci, and genetic markers have been used to map quantitative trait loci (QTLs) auxiliarily. The method of multiple interval mapping (MIM) provides an appropriate way for mapping QTL using genetic makers. However, the computation in the MIM seems infeasible for a large number of marker intervals. Nowadays, the Dantzig selector (DS) method proves to be a more efficient method to estimate model effects in a linear model when the number of parameters is (much) larger than the sample size, which has not been applied to genetic mapping for QTL. In this paper, we developed a two-step method for mapping QTL based on the MIM, and we also illustrate the feasibility of adopting the DS to estimate marker or QTL effects. Simulation results showed that the proposed method performed satisfactorily well by comparisons with the existing MIM method, and the analysis to real data set also tested the practicability and efficiency of the DS method in genetic mapping.
authors.affiliation: Key Laboratory for Applied Statistics of MOE and School of Mathematics and Statistics, Northeast Normal University, Changchun 130024, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Ma
authors.affiliation: School of Mathematical Sciences, Heilongjiang University, Harbin 150080, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: School of Mathematical Sciences, Heilongjiang University, Harbin 150080, China.
authors.forename: Shuanglin
authors.initials: S
authors.lastname: Zhang
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D005819:Genetic Markers; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D010641:Phenotype; D040641:Quantitative Trait Loci
chemical_list: D005819:Genetic Markers