title: Successful remission of Evans syndrome associated with Graves' disease by using propylthiouracil monotherapy.
abstract: A 46-year-old woman with Graves' disease was admitted for anemia and thrombocytopenia. She had previously been treated with methimazole but she self-discontinued the treatment 6 months prior to admission. She was diagnosed with Evans syndrome associated with Graves' disease and treated with propylthiouracil without corticosteroids, which normalized her thyroglobulin level. Surprisingly, while Evans syndrome is characterized by frequent relapses, this patient has been in remission of Evans syndrome for approximately 4 years. The remission of Evans syndrome associated with Graves' disease in the absence of immunosuppressive therapy suggests that these 2 diseases have a common pathogenetic mechanism.
authors.affiliation: Department of Hematology, Niigata University Graduate School of Medical and Dental Sciences, Japan. tushiki@med.niigata-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Ushiki
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Masuko
authors.forename: Koji
authors.initials: K
authors.lastname: Nikkuni
authors.forename: Jun
authors.initials: J
authors.lastname: Terukina-Yoshida
authors.forename: Ayako
authors.initials: A
authors.lastname: Momotsu-Nanba
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morikawa
authors.forename: Akio
authors.initials: A
authors.lastname: Usami
authors.forename: Ichiro
authors.initials: I
authors.lastname: Fuse
authors.forename: Ken
authors.initials: K
authors.lastname: Toba
authors.forename: Kazue
authors.initials: K
authors.lastname: Takai
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006111:Graves Disease / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D011441:Propylthiouracil / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D011441:Propylthiouracil