title: Prorocentrol, a polyoxy linear carbon chain compound isolated from the toxic dinoflagellate Prorocentrum hoffmannianum.
abstract: A polyoxy linear carbon chain compound, prorocentrol (1), was isolated from cultured cells of the dinoflagellate Prorocentrum hoffmannianum, which produces a polyether carboxylic acid, okadaic acid. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Compound 1 possesses 30 hydroxy groups, 1 ketone, and 8 double bonds on the C65-linear carbon chain. Its partial relative configuration was deduced by the proton-proton and long-range carbon-proton coupling constants, and compound 1 showed moderate cytotoxicity and antidiatom activity.
authors.affiliation: Department of Chemistry, School of Science, University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Sugahara
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Michio
authors.initials: M
authors.lastname: Murata
authors.forename: Masayuki
authors.initials: M
authors.lastname: Satake
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tachibana
mesh_terms: D004141:Dinoflagellida / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D011714:Pyrans / Q000737:chemistry*
chemical_list: D011714:Pyrans; C560202:prorocentrol