title: [5-FU/l-LV therapy is useful for hemodialysis patients with advanced gastric cancer].
abstract: A 71-year-old man receiving maintenance dialysis because of diabetic nephropathy presented with hematemesis at another hospital in January 2008. A gastrointestinal endoscopy demonstrated a II a-like lesion in the angle of the stomach, and he was admitted to our hospital. A diagnosis of gastric adenocarcinoma (cT2N2M0, Stage IIIA) was made. An operation could not be performed because of the high risk, so combination chemotherapy with 5-FU and l-LV was initiated. After 3 courses of treatment, the size of the primary tumor was markedly reduced. After 6 courses, the primary lesion had changed to a scar, and an endoscopic biopsy revealed no cancer cells. His performance status did not deteriorate, and no serious adverse events occurred during the course of treatment. Chemotherapy was continued because the overall response was SD. 5-FU/l-LV therapy should be considered as a safe and useful treatment for a hemodialysis patient with advanced gastric cancer.
authors.affiliation: Dept. of Internal Medicine, Showa University Northern Yokohama Hospital, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Saito
authors.forename: Ken
authors.initials: K
authors.lastname: Shimada
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Ohno
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Toshima
authors.forename: Koji
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Miyashita
authors.forename: Shizuma
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Takinishi
authors.forename: Akio
authors.initials: A
authors.lastname: Miyokawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Itoh
authors.forename: Akiko
authors.initials: A
authors.lastname: Sakashita
mesh_terms: D000368:Aged; D001706:Biopsy; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009367:Neoplasm Staging; D006435:Renal Dialysis; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
chemical_list: D002955:Leucovorin; D005472:Fluorouracil