title: Does patent foramen ovale closure have an anti-arrhythmic effect? A meta-analysis.
abstract: BACKGROUND
  Atrial tachyarrhythmias are associated with patent foramen ovale. The objective was to determine the anti-arrhythmic effect of patent foramen ovale closure on pre-existing atrial tachyarrhythmias.
  
  
  METHODS
  Medline, EMBASE, Cochrane Library, and Google Scholar databases were searched between 1967 and 2010. The search was expanded using the 'related articles' function and reference lists of key studies. All studies reporting pre- and post-closure incidence (or prevalence) of atrial tachyarrhythmia in the same patient population were included. Random and fixed effect meta-analyses were used to aggregate the data.
  
  
  RESULTS
  Six studies were identified including 2570 patients who underwent percutaneous closure. Atrial fibrillation was in fact the only AT reported in all studies. Meta-analysis using a fixed effects model demonstrated a significant reduction in the prevalence of atrial fibrillation with an OR of 0.43 (95% CI 0.26-0.71). When using the random-effects model, OR was 0.44 (95% CI 0.18-1.04) with a statistically significant trend demonstrated (test for overall effect: Z=1.87, p=0.06).
  
  
  CONCLUSIONS
  Closure of a patent foramen ovale may be associated with reduction in the prevalence of atrial fibrillation.
authors.affiliation: Surgical Epidemiology Unit, Department of Biosurgery and Surgical Technology, Imperial College London, 10th Floor QEQM Building, St Mary's Hospital, London W2 1NY, United Kingdom.
authors.forename: Omar A
authors.initials: OA
authors.lastname: Jarral
authors.forename: Srdjan
authors.initials: S
authors.lastname: Saso
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Vecht
authors.forename: Leanne
authors.initials: L
authors.lastname: Harling
authors.forename: Christopher
authors.initials: C
authors.lastname: Rao
authors.forename: Kamran
authors.initials: K
authors.lastname: Ahmed
authors.forename: Michael A
authors.initials: MA
authors.lastname: Gatzoulis
authors.forename: Iqbal S
authors.initials: IS
authors.lastname: Malik
authors.forename: Thanos
authors.initials: T
authors.lastname: Athanasiou
mesh_terms: D001145:Arrhythmias, Cardiac / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control*; D054092:Foramen Ovale, Patent / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D011446:Prospective Studies; D012189:Retrospective Studies