title: Tetraspanin protein contributions to cancer.
abstract: Among the 33 human tetraspanin proteins, CD151, CD9 and Tspan12 play particularly important roles in cancer. Tetraspanin CD151, in partnership with integrins α6β1 and α6β4, modulates tumour cell growth, invasion, migration, metastasis, signalling and drug sensitivity. Tetraspanin CD9 has suppressor functions in multiple tumour cell types. Major CD9 partner proteins, such as EWI-2 and EWI-F, may modulate these tumour-suppressor functions. Tetraspanin Tspan12 mutations are linked to a human disease called familial exudative vitreoretinopathy. In addition, as a regulator of the metalloprotease ADAM10 (a disintegrin and metalloprotease 10) maturation and function, Tspan12 probably contributes to the pro-tumorigenic functions of ADAM10.
authors.affiliation: Department of Cancer Biology and AIDS, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
authors.forename: Hong-Xing
authors.initials: HX
authors.lastname: Wang
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Li
authors.forename: Chandan
authors.initials: C
authors.lastname: Sharma
authors.forename: Konstantin
authors.initials: K
authors.lastname: Knoblich
authors.forename: Martin E
authors.initials: ME
authors.lastname: Hemler
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism / Q000502:physiology; D000072197:ADAM10 Protein; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism / Q000502:physiology; D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding / Q000235:genetics / Q000502:physiology; D060185:Tetraspanin 24; D060245:Tetraspanin 29; D059470:Tetraspanins
chemical_list: D015703:Antigens, CD; C554715:CD151 protein, human; C554869:CD9 protein, human; D016023:Integrins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C545100:TSPAN12 protein, human; D060185:Tetraspanin 24; D060245:Tetraspanin 29; D059470:Tetraspanins; D053829:Amyloid Precursor Protein Secretases; D051722:ADAM Proteins; D000072197:ADAM10 Protein; C491236:ADAM10 protein, human