title: Autotaxin: its role in biology of melanoma cells and as a pharmacological target.
abstract: Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA(1)-LPA(6)) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed.
authors.affiliation: Department of Therapy Monitoring and Pharmacogenetics, Medical University of Gdańsk, Debinki 7, 80-211 Gdańsk, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Jankowski