title: [Systematic review of validation phase of breast cancer sentinel lymph node biopsy results in China].
abstract: OBJECTIVE
  To explore the studies and application status of sentinel lymph node biopsy (SLNB) in breast cancer in China by statistically analyzing the relevant domestic literature.
  
  
  METHODS
  The literatures published from January 1999 to December 2005 were searched in the databases of China, Info, CBM and CNKI retrieval system with "breast tumor, SLN and SLNB" as the key words. A total of 88 manuscripts were selected with 2 new reports of SLNB. The successful rate, accuracy, false-negative rate and sensitivity of SLNB were analyzed by SPSS 10.0 statistical analysis software.
  
  
  RESULTS
  Among a total of 6282 patients, the detection rate of SLNB was 90.82% (5705/6282) and the overall false-negative rate 9.69% (259/2671). The prediction sensitivity, specificity, false positive rate, accuracy, negative and positive predictive value of SLN for axillary lymph nodes status were 90.30%, 99.64%, 0.41%, 86.52%, 92.11% and 99.55% respectively.
  
  
  CONCLUSIONS
  SLNB can accurately predict the axillary lymph node metastasis. And its detection rate is correlated with patient age and tumor location. The detection rate and false-negative rate has nothing to do with the tracer injection site. A combined regimen has a higher detection rate and a low false negative rate. Affecting the whole breast, SLN is not correlated with a particular area of breast. The validation phase of SLNB in breast cancer is currently feasible in China.
authors.affiliation: Breast Cancer Center, Shandong Cancer Hospital & Institute, Jinan 250117, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zheng
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Wen-Shu
authors.initials: WS
authors.lastname: Zuo
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Yu
authors.forename: Yan-Song
authors.initials: YS
authors.lastname: Liu
authors.forename: Mei-Zhu
authors.initials: MZ
authors.lastname: Zheng
authors.forename: Sheng-Fang
authors.initials: SF
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D055815:Young Adult