title: Cell adhesion on nanotextured slippery superhydrophobic substrates.
abstract: In this work, the response of Saos2 cells to polymeric surfaces with different roughness/density of nanometric dots produced by a tailored plasma-etching process has been studied. Topographical features have been evaluated by atomic force microscopy, while wetting behavior, in terms of water-surface adhesion energy, has been evaluated by measurements of drop sliding angle. Saos2 cytocompatibility has been investigated by scanning electron microscopy, fluorescent microscopy, and optical microscopy. The similarity in outer chemical composition has allowed isolation of the impact of the topographical features on cellular behavior. The results indicate that Saos2 cells respond differently to surfaces with different nanoscale topographical features, clearly showing a certain inhibition in cell adhesion when the nanoscale is particularly small. This effect appears to be attenuated in surfaces with relatively bigger nanofeatures, though these express a more pronounced slippery/dry wetting character.
authors.affiliation: Department of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Di Mundo
authors.forename: Marina
authors.initials: M
authors.lastname: Nardulli
authors.forename: Antonella
authors.initials: A
authors.lastname: Milella
authors.forename: Pietro
authors.initials: P
authors.lastname: Favia
authors.forename: Riccardo
authors.initials: R
authors.lastname: d'Agostino
authors.forename: Roberto
authors.initials: R
authors.lastname: Gristina
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects*; D002460:Cell Line; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers; D017155:Wettability
chemical_list: D011108:Polymers