title: Continuous-flow organic synthesis: a tool for the modern medicinal chemist.
abstract: Medicinal chemists are under increasing pressure, not only to identify lead compounds and optimize them into clinical candidates, but also to produce materials in sufficient quantities for subsequent investigation. With this in mind, continuous-flow methodology presents an opportunity to reduce the time taken to, first, identify the compound and, second, scale the process for evaluation and, where necessary, production. It is therefore the aim of this review to provide the reader with an insight into the advantages associated with the use of continuous-flow chemistry through the use of strategically selected literature examples.
authors.affiliation: Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen, The Netherlands. c.wiles@chemtrix.com
authors.forename: Charlotte
authors.initials: C
authors.lastname: Wiles
authors.forename: Paul
authors.initials: P
authors.lastname: Watts
mesh_terms: D057930:Click Chemistry; D054879:Halogenation; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D009930:Organic Chemicals; D011355:Prodrugs