title: Vitreous and serum levels of transthyretin (TTR) in high myopia patients are correlated with ocular pathologies.
abstract: OBJECTIVE
  To detect serum and vitreous transthyretin (TTR) in high myopia patients and to evaluate potential associations between TTR and clinical parameters and ocular pathologies, including different ocular pathologies.
  
  
  METHODS
  Serum samples from 16 high myopia patients and 4 controls were analyzed by LTQ-MASS. Serum samples from 116 high myopia patients and 86 healthy controls were tested by Western blots and ELISA. Eight healthy and 40 pathologic vitreous samples were analyzed by ELISA. And corresponding serum samples were also analyzed by ELISA.
  
  
  RESULTS
  Significant increased TTR serum levels were detected in high myopia patients compared to healthy controls. The high levels of serum TTR were associated with ocular pathologies, long axial length, and low visual acuity. TTR in high myopia patients with macular hole and macular detachment was upregulated in both vitreous and the corresponding serum samples. TTR levels in serum samples of high myopia patients with long axial lengths were higher than in the vitreous.
  
  
  CONCLUSIONS
  Serum TTR may be a biomarker for high myopia patients with ocular pathologies.
authors.affiliation: Department of Ophthalmology, Shanghai Jiao Tong University Affiliated First People's Hospital, Haining Road 100, Shanghai 200080, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Shao
authors.forename: Yu
authors.initials: Y
authors.lastname: Xin
authors.forename: Rongxiu
authors.initials: R
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Fan
mesh_terms: D000328:Adult; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000097:blood* / Q000378:metabolism*; D011228:Prealbumin / Q000378:metabolism*; D044967:Serum / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D011228:Prealbumin