title: The influence of obesity on ICSI outcomes in women with polycystic ovary syndrome.
abstract: The objective of the study was to compare intracytoplasmic sperm injection (ICSI) outcome and gonadotropin doses between obese women with PCOS and non-obese patients with PCOS. This follow-up study represents ICSI outcomes in obese women with PCOS (BMI ≥ 30 kg/m(2)) compared with non-obese women with PCOS (BMI < 30 kg/m(2)). Obese (n = 18) and non-obese (n = 26) women with PCOS underwent long protocol pituitary suppression, ovarian stimulation and ICSI with fresh embryo transfer. Obese patients with PCOS required higher doses of gonadotropin (2994 IU vs 1719 IU; p < 0.001). Miscarriage rate was significantly higher in obese women compared with the non-obese women with PCOS (60% vs 6.7%, p = 0.002). Our results are valuable for counselling couples before initiation of assisted reproduction techniques (ART).
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Erciyes University, Gevher Nesibe Hospital, 38039 Kayseri, Turkey. mtozgun@erciyes.edu.tr
authors.forename: M T
authors.initials: MT
authors.lastname: Ozgun
authors.forename: S
authors.initials: S
authors.lastname: Uludag
authors.forename: G
authors.initials: G
authors.lastname: Oner
authors.forename: C
authors.initials: C
authors.lastname: Batukan
authors.forename: E M
authors.initials: EM
authors.lastname: Aygen
authors.forename: Y
authors.initials: Y
authors.lastname: Sahin
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D015992:Body Mass Index; D004624:Embryo Transfer; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D050498:Live Birth; D009765:Obesity / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D011994:Recombinant Proteins / Q000008:administration & dosage; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D005640:Follicle Stimulating Hormone