title: Helicobacter pylori specific IgG antibody and serum magnesium in type-2 diabetes mellitus chronic kidney disease patients.
abstract: Infection with Helicobacter pylori (H. pylori) is common in diabetics with inadequately controlled blood sugar. Evidence has been published suggesting that the prevalence of H. pylori infection is higher in patients with type-2 diabetes mellitus (T2DM) as opposed to the normal population. This study was conducted to investigate the association between serum magnesium (Mg) levels and H. pylori infection in T2DM patients with various glomerular function rates (GFRs). A total of 94 patients with mean age of 62 (±12) years and the duration of diabetes of 7.9 (±6.9) years (median: 7 years), were studied. The mean HbA1c in the study patients was 7.8 (±1.9) g/dL. The mean serum Mg was 2 (±0.50) mg/dL (median: 2 mg/dL), and the mean creatinine clearance was 62 (±23) mL/min (median: 64 mL/min). The mean value of serum H. pylori specific IgG antibody titers in the study patients was 3.9 ± 4 U/mL (median 1.9 U/mL). No significant relationship was found between the serum H. pylori specific IgG antibody titers and serum Mg levels and the age of the patients, creatinine clearance and duration of diabetes mellitus (DM). We could not find any significant positive association between serum Mg and H. pylori infection even among patients who had GFR below 40 mL/min. In a previous study on a group of patients on hemodialysis (HD), we had found a positive correlation between serum Mg and H. pylori infection. Thus, the high serum Mg level as well as its higher concentration in the gastric mucosa might facilitate the colonization of H. pylori in the stomach of patients on HD, but not in patients with various stages of renal failure that were not on HD.
authors.affiliation: Department of Internal Medicine, Shahrekord University of Medical Sciences, Hajar Hospital, Shahrekord, Iran. hamidnasri@yahoo.com
authors.forename: Azar
authors.initials: A
authors.lastname: Baradaran
authors.forename: Hamid
authors.initials: H
authors.lastname: Nasri
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology*; D003928:Diabetic Nephropathies / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000378:metabolism; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007492:Iran / Q000453:epidemiology; D007668:Kidney / Q000503:physiopathology; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D003404:Creatinine; D006442:Glycated Hemoglobin; D007074:Immunoglobulin G; D008274:Magnesium; C517652:hemoglobin A1c protein, human