title: Importance of realistic LVAD profiles for assisted aortic simulations: evaluation of optimal outflow anastomosis locations.
abstract: Left ventricular assist devices (LVADs) are carefully designed, but the significance of the implantation configuration and interaction with the vasculature is complex and not fully determined. The present study employs computational fluid dynamics to investigate the importance of applying a realistic LVAD profile when evaluating assisted aortic flow fields and subsequently compares a number of potential anastomosis locations in a patient-specific aortic geometry. The outflow profile of the Berlin Heart INCOR® device was provided by Berlin Heart GmbH (Berlin, Germany) and the cannula was attached at a number of locations on the aorta. Simulations were conducted to compare a flat profile against the real LVAD profile. The results illustrate the importance of applying an LVAD profile. It not only affects the magnitude and distribution of oscillatory shear index, but also the distribution of flow to the great arteries. The ascending aorta was identified as the optimal location for the anastomosis.
authors.affiliation: Group of Medical Physics, School of Medicine and Biomedical Sciences, The Royal Hallamshire Hospital, University of Sheffield, Room I108, Beech Hill Road, Sheffield S10 2RX, UK. a.g.brown@sheffield.ac.uk
authors.forename: Alistair Graham
authors.initials: AG
authors.lastname: Brown
authors.forename: Yubing
authors.initials: Y
authors.lastname: Shi
authors.forename: Andreas
authors.initials: A
authors.lastname: Arndt
authors.forename: Jörg
authors.initials: J
authors.lastname: Müller
authors.forename: Patricia
authors.initials: P
authors.lastname: Lawford
authors.forename: David Rodney
authors.initials: DR
authors.lastname: Hose
mesh_terms: D000714:Anastomosis, Surgical; D001011:Aorta / Q000033:anatomy & histology*; D006353:Heart-Assist Devices; D006801:Humans