title: Electrochemical selective detection of uric acid using a copper-modified carbon electrode.
abstract: The uric acid (UA) level in (human) serum is an important indicator of several diseases; however, its electrochemical detection is difficult because the oxidation potentials of UA and ascorbic acid (AA) are very close. In this study, we have developed a simple and efficient UA detection method using a copper-modified carbon electrode. The detection principle is based on the selective oxidation of AA by Cu(II), wherein Cu(II) reacts selectively with AA but not with UA. By performing this specific reaction on an electrode surface, we have successfully distinguished the oxidation potential of UA without AA interference.
authors.affiliation: Research Organization of Science & Engineering, Ritsumeikan University, Kusatsu, Shiga, Japan. sakahiro@fc.ritsumei.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Ranko
authors.initials: R
authors.lastname: Hatsuda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Miyamura
authors.forename: Haruki
authors.initials: H
authors.lastname: Shiraishi
authors.forename: Susumu
authors.initials: S
authors.lastname: Sugiyama
mesh_terms: D001205:Ascorbic Acid / Q000097:blood; D015374:Biosensing Techniques / Q000379:methods; D001774:Blood Chemical Analysis / Q000295:instrumentation*; D002244:Carbon / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D004566:Electrodes; D006801:Humans; D010084:Oxidation-Reduction; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D002244:Carbon; D003300:Copper; D001205:Ascorbic Acid