title: Novel therapies for coeliac disease.
abstract: Coeliac disease is a widespread, lifelong disorder for which dietary control represents the only accepted form of therapy. There is an unmet need for nondietary therapies to treat this condition. Most ongoing and emerging drug-discovery programmes are based on the understanding that coeliac disease is caused by an inappropriate T-cell-mediated immune response to dietary gluten proteins. Recent genome-wide association studies lend further support to this pathogenic model. The central role of human leucocyte antigen genes has been validated, and a number of new risk loci have been identified, most of which are related to the biology of T cells and antigen-presenting cells. Here, we review the status of potential nondietary therapies under consideration for coeliac disease. We conclude that future development of novel therapies will be aided considerably by the identification of new, preferably noninvasive, surrogate markers for coeliac disease activity.
authors.affiliation: Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway. l.m.sollid@medisin.uio.no
authors.forename: L M
authors.initials: LM
authors.lastname: Sollid
authors.forename: C
authors.initials: C
authors.lastname: Khosla
mesh_terms: D002446:Celiac Disease / Q000188:drug therapy*; D003888:Desensitization, Immunologic / Q000379:methods; D055808:Drug Discovery / Q000379:methods; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D019204:GTP-Binding Proteins / Q000037:antagonists & inhibitors; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D005983:Glutens / Q000276:immunology / Q000493:pharmacokinetics; D006801:Humans; D008658:Inactivation, Metabolic; D058990:Molecular Targeted Therapy / Q000379:methods; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000037:antagonists & inhibitors
chemical_list: D004791:Enzyme Inhibitors; D005765:Gastrointestinal Agents; D005983:Glutens; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins