title: Human tissue kallikrein promoted activation of the ipsilesional sensorimotor cortex after acute cerebral infarction.
abstract: OBJECTIVE
  Kallikrein, a serine proteinase, has been reported to have many functions, such as selectively dilating arterioles in the ischemic area and enhancing angiogenesis and neurogenesis. Therefore, it may promote cerebral poststroke reorganization. We observed the effect of human tissue kallikrein on the brain motor activation of acute ischemic stroke patients and evaluated patient condition severity and prognosis.
  
  
  METHODS
  Forty-four cases suffering from cerebral infarction between 6 and 72 h of onset were randomly assigned into the kallikrein group (n = 24) and the control group (n = 20). The control group was given conventional treatment, whereas the kallikrein group was given both conventional treatment and human tissue kallikrein over the course of 12-14 days. The activation of the sensorimotor cortex (SMC) and cerebellum, the affected forefinger strength and the NIHSS scores were evaluated before and after treatment. The MBI and MRS scores were assessed at 30 and 90 days after stroke onset.
  
  
  RESULTS
  There were no differences between the two groups in activation volume, patient condition and scores before treatment. After treatment, the ipsilesional SMC activation volume was significantly larger and the increase in the volume was significantly greater in the kallikrein group than in the control group (p < 0.05 for both). The NIHSS score was significantly smaller and the improvement in the score was significantly greater in the kallikrein group after treatment (p < 0.05 for both). Moreover, the MBI scores at 30 days were significantly higher, whereas the MRS scores at 30 days were significantly lower in the kallikrein group than in the control group (p < 0.05 for both).
  
  
  CONCLUSIONS
  Kallikrein improved neural function effectively and quickly after stroke, and promoting cerebral reorganization might be an important mechanism for kallikrein in the treatment of acute cerebral infarction.
authors.affiliation: Department of Neurology, Sun Yat-Sen Hospital of Sun Yat-Sen University, Guangzhou, PR China.
authors.forename: Yi-Dong
authors.initials: YD
authors.lastname: Wang
authors.forename: Rui-Yan
authors.initials: RY
authors.lastname: Lu
authors.forename: Xiao-Xiong
authors.initials: XX
authors.lastname: Huang
authors.forename: Fang
authors.initials: F
authors.lastname: Yuan
authors.forename: Tao
authors.initials: T
authors.lastname: Hu
authors.forename: Ying
authors.initials: Y
authors.lastname: Peng
authors.forename: Sui-Qiao
authors.initials: SQ
authors.lastname: Huang
mesh_terms: D015670:Acupuncture Therapy; D002531:Cerebellum / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects*; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000473:pathology; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D018697:Nootropic Agents / Q000627:therapeutic use; D020127:Recovery of Function / Q000187:drug effects*; D020840:Tissue Kallikreins / Q000627:therapeutic use*
chemical_list: D018697:Nootropic Agents; D003566:Cytidine Diphosphate Choline; D020840:Tissue Kallikreins