title: Ag/ThioClickFerrophos-catalyzed enantioselective Mannich reaction and amination of glycine Schiff base.
abstract: The AgOAc/ThioClickFerrophos complex catalyzed the asymmetric Mannich reaction of glycine Schiff base with N-tosylimines effectively to give a mixture of syn and anti adducts (syn/anti = 60/40-70/30) at high yields with high enantioselectivities (up to 98% ee). The complex also catalyzed the asymmetric amination of glycine Schiff base with di-tert-butyl azodicarboxylate with high enantioselectivity.
authors.affiliation: Department of Applied Chemistry, Institute of Science and Engineering, Chuo University, 1-13-27 Kasuga, Tokyo 112-8551, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Imae
authors.forename: Kenta
authors.initials: K
authors.lastname: Shimizu
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ogata
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Fukuzawa
mesh_terms: D000586:Amination; D002384:Catalysis; D005998:Glycine / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D009942:Organometallic Compounds; D012545:Schiff Bases; D012834:Silver; D005998:Glycine