title: Multimodal imaging of functional networks and event-related potentials in performance monitoring.
abstract: The stop-signal task is a prototypical experiment to study cognitive processes that mediate successful performance in a rapidly changing environment. By means of simultaneous recording and combined analysis of electroencephalography and functional magnetic resonance imaging on single trial level, we provide a comprehensive view on brain responses related to performance monitoring in this task. Three types of event-related EEG components were analyzed: a go-related N2/P3-complex devoid of motor-inhibition, the stop-related N2/P3-complex and the error-related negativity with its consecutive error positivity. Relevant functional networks were identified by crossmodal correlation analyses in a parallel independent component analysis framework. Go-related potentials were associated with a midcingulate network known to participate in the processing of conflicts, a left-dominant somatosensory-motor network, and deactivations in visual cortices. Stop-related brain responses in association with the N2/P3-complex were seen with networks known to support motor and cognitive inhibition, including parts of the basal ganglia, the anterior midcingulate cortex and pre-supplementary motor area as well as the anterior insula. Error-related brain responses showed a similar constellation with additional recruitment of the posterior insula and the inferior frontal cortex. Our data clearly indicate that the pre-supplementary motor area is involved in inhibitory mechanisms but not in the processing of conflicts per se.
authors.affiliation: Institute for Psychology, University of Oldenburg, Oldenburg, Germany. rene.huster@uni-oldenburg.de
authors.forename: R J
authors.initials: RJ
authors.lastname: Huster
authors.forename: T
authors.initials: T
authors.lastname: Eichele
authors.forename: S
authors.initials: S
authors.lastname: Enriquez-Geppert
authors.forename: A
authors.initials: A
authors.lastname: Wollbrink
authors.forename: H
authors.initials: H
authors.lastname: Kugel
authors.forename: C
authors.initials: C
authors.lastname: Konrad
authors.forename: C
authors.initials: C
authors.lastname: Pantev
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000502:physiology; D009415:Nerve Net / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D025341:Principal Component Analysis; D011597:Psychomotor Performance / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology; D014110:Touch / Q000502:physiology; D055815:Young Adult
chemical_list: D010100:Oxygen