title: Novel types of staphylococcal cassette chromosome mec elements identified in clonal complex 398 methicillin-resistant Staphylococcus aureus strains.
abstract: The structures of staphylococcal cassette chromosome mec (SCCmec) elements carried by 31 clonal complex 398 (CC398) methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from the participants at a conference were analyzed. The SCCmecs were classified into novel types, namely, IX, X, V(5C2&5) subtype c, and IVa. Type V(5C2&5) subtype c, IX, and X SCCmecs carried genes conferring resistance to metals. The structures of SCCmecs from CC398 strains were distinct from those normally found in humans, adding to the evidence that humans are not the original host for CC398.
authors.affiliation: Department of Bacteriology, School of Medicine, Juntendo University, Tokyo, Japan.
authors.forename: Shanshuang
authors.initials: S
authors.lastname: Li
authors.forename: Robert Leo
authors.initials: RL
authors.lastname: Skov
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.forename: Anders Rhod
authors.initials: AR
authors.lastname: Larsen
authors.forename: Jesper
authors.initials: J
authors.lastname: Larsen
authors.forename: Marit
authors.initials: M
authors.lastname: Sørum
authors.forename: Mireille
authors.initials: M
authors.lastname: Wulf
authors.forename: Andreas
authors.initials: A
authors.lastname: Voss
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: Teruyo
authors.initials: T
authors.lastname: Ito
mesh_terms: D000818:Animals; D002876:Chromosomes, Bacterial; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D008670:Metals / Q000378:metabolism / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics*; D013552:Swine / Q000382:microbiology*
chemical_list: D008670:Metals