title: The yin and yang of signaling in Tregs and TH17 cells.
abstract: Substantial advances in our understanding of the developmental and functional relationship between regulatory T cells (T(regs)) and T helper 17 (T(H)17) cells and their potential clinical applications have been made. In response to these breakthroughs, the second international conference entitled "China Tregs/Th17 2010 Shanghai Conference," held in Shanghai, China, was dedicated to this topic. Various types of T(regs) and T(H)17 cells, as well as their relevant cytokines, were discussed. Here, we summarize some of the findings shared at the conference, specifically focusing on the biology of T(H)17 cells, including interleukin-17 (IL-17)-producing innate cells, T(regs), and the factors that control the critical balance between T(regs) and cells of the T(H)17 lineage.
authors.affiliation: Immunology and Hematopoiesis Division, Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
authors.forename: Fan
authors.initials: F
authors.lastname: Pan
authors.forename: Huimin
authors.initials: H
authors.lastname: Fan
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Liu
authors.forename: Shuiping
authors.initials: S
authors.lastname: Jiang
mesh_terms: D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D016709:Yin-Yang
chemical_list: D020381:Interleukin-17