title: The prevalence of ocular complications in leprosy patients seen in the United Kingdom over a period of 21 years.
abstract: OBJECTIVE
  The objective of this study was to determine the prevalence of ocular complications and blindness among leprosy patients presenting in the United Kingdom.
  
  
  METHODS
  Observational prospective study.
  
  
  RESULTS
  A total of 126 consecutive leprosy patients attending their ophthalmic visit were examined, out of which 18 patients were blind in one eye (14.3%) and five patients were blind in both the eyes (4.0%). Visual acuity of ≥ 6/18 was present in 96 patients (76.2%). A total of 65 patients (51.6%) had an ocular complication and 28 patients (22.2%) had a sight-threatening leprosy complication (lagophthalmos, severe corneal, or iris disease). The most common ocular complications were impaired lid closure (24 patients, 19%), impaired corneal sensation (20 patients, 15.9%), cataract (20 patients, 15.9%), mild corneal opacity (17 patients, 13.5%), and iris atrophy (17 patients, 13.5%). Impaired corneal sensation was associated with vision <6/18 (P<0.001, OR 13.5, 95% CI 5.14-35.44) and vision <3/60 (P=0.01 OR 6.42, 95% CI 2.15-19.15). Impaired lid closure was significantly associated with increasing age (P=0.029, OR 1.039, 95% CI 1.0-1.08) and vision <3/60 (P=0.03, OR 6.06, 95% CI 1.81-20.24).
  
  
  CONCLUSIONS
  There is a significant rate of ocular complications and blindness seen in leprosy patients in the United Kingdom, and over one in five had a potentially sight-threatening ocular complication. Health professionals and all leprosy patients, including those cured of the disease, need to be aware that new eye symptoms and signs require prompt ophthalmology review to prevent avoidable blindness, due to the life-long risk of sight-threatening ocular complications.
authors.affiliation: Moorfields Eye Hospital, London, UK. aeeshamalik@yahoo.co.uk
authors.forename: A N J
authors.initials: AN
authors.lastname: Malik
authors.forename: R W
authors.initials: RW
authors.lastname: Morris
authors.forename: T J
authors.initials: TJ
authors.lastname: Ffytche
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005128:Eye Diseases / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D007918:Leprosy / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D006113:United Kingdom / Q000453:epidemiology; D014786:Vision Disorders / Q000453:epidemiology; D055815:Young Adult