title: Durable remission of leptomeningeal metastases from hormone-responsive prostate cancer.
abstract: Prostate cancer is rarely associated with leptomeningeal metastasis. An 87-year-old man with a history of prostate cancer presented with leptomeningeal metastasis. He received hormonal therapy with leuprolide. Subsequently, he achieved an impressive response, indicated by a constant fall in his PSA levels and by the stabilization of leptomeningeal disease and clinical improvement. Hormonal therapy may be effective in inducing remission in hormone-sensitive prostate cancer with leptomeningeal metastasis.
authors.affiliation: Department of Neurosciences, Moores UCSD Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, Suite 3336, La Jolla, CA 92093-0819, USA.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.forename: Ali
authors.initials: A
authors.lastname: Mahta
authors.forename: Ryan Y
authors.initials: RY
authors.lastname: Kim
authors.forename: Serra
authors.initials: S
authors.lastname: Akar
authors.forename: Santosh
authors.initials: S
authors.lastname: Kesari
mesh_terms: D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000556:secondary; D009376:Neoplasms, Hormone-Dependent / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D012074:Remission Induction
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017430:Prostate-Specific Antigen; D016729:Leuprolide