title: [Clinical benefits of using the phosphorylcholine coating of an extracorporeal circuit in babies weighing less than 5 kg].
abstract: The paper presents the results of studying the perfusion and postoperative periods in 24 neonates and babies weighing less than 5 kg who have undergone radical and hemodynamic correction of transposition of the great arteries under extracorporeal circulation. According to whether the phosphorylcholine coating of an extracorporeal circuit was available, the patients were allocated into 2 groups: (1) Phisio and (2) coating-free. Based on the time course of changes in the count of white blood cells and platelets and in the activity of aspartate aminotransferase, neutrophil elastase, and antitrypsin, in the levels of tumor necrosis factor-alpha, IL-8, and IL-10, in postperfusion hemohydrobalance, and in the indicators of the clinical course in the postoperative period, the authors have concluded that a reduction in infectious complications (from 75 to 11%) and simplification of the pattern of noninfectious pathology in the Phisio group are associated with a more balanced systemic inflammatory response and less tissue damage.
authors.forename: T B
authors.initials: TB
authors.lastname: Averina
authors.forename: D Sh
authors.initials: DSh
authors.lastname: Samuilova
mesh_terms: D001724:Birth Weight; D006348:Cardiac Surgical Procedures / Q000379:methods*; D020099:Coated Materials, Biocompatible; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000295:instrumentation*; D006801:Humans; D007231:Infant, Newborn; D010767:Phosphorylcholine; D011184:Postoperative Period; D013499:Surface Properties; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D014188:Transposition of Great Vessels / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D010767:Phosphorylcholine