title: Comparison of costs and benefits of breast cancer screening with mammography, ultrasonography, and MRI.
abstract: Screening mammography performed annually on all women beginning at age 40 years has reduced breast cancer deaths by 30% to 50%. The cost per year of life saved is well within the range for other commonly accepted medical interventions. Various studies have estimated that reduction in treatment costs through early screening detection may be 30% to 100% or more of the cost of screening. Magnetic resonance imaging (MRI) screening is also cost-effective for very high-risk women, such as BRCA carriers, and others at 20% or greater lifetime risk. Further studies are needed to determine whether MRI is cost-effective for those at moderately high (15%-20%) lifetime risk. Future technical advances could make MRI more cost-effective than it is today. Automated whole-breast ultrasonography will probably prove cost-effective as a supplement to mammography for women with dense breasts.
authors.affiliation: Department of Radiological Sciences, UC Irvine Medical Center, Orange, CA 92868, USA. sfeig@uci.edu
authors.forename: Stephen
authors.initials: S
authors.lastname: Feig
mesh_terms: D000328:Adult; D000368:Aged; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D001706:Biopsy / Q000191:economics; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D003362:Cost-Benefit Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008017:Life Expectancy; D008279:Magnetic Resonance Imaging / Q000191:economics*; D008327:Mammography / Q000191:economics*; D008403:Mass Screening / Q000191:economics / Q000379:methods; D008875:Middle Aged; D009154:Mutation; D017410:Practice Guidelines as Topic; D011878:Radiotherapy / Q000009:adverse effects; D012307:Risk Factors; D014463:Ultrasonography / Q000191:economics*
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human