title: A label-free DNA reduced graphene oxide-based fluorescent sensor for highly sensitive and selective detection of hemin.
abstract: G-quadruplex structure aptamer (PS2.M) can capture acridine orange (AO) from reduced graphene oxide (rGO). When the AO-PS2.M/rGO mixture is incubated with hemin, the specific binding of hemin with PS2.M results in a release of AO from PS2.M and return of AO back to rGO. Based on the quenching of fluorescence, the target hemin was detected sensitively and selectively, giving a detection limit of 50 nM.
authors.affiliation: Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Wei Tao
authors.initials: WT
authors.lastname: Huang
authors.forename: Hong Qun
authors.initials: HQ
authors.lastname: Luo
authors.forename: Nian Bing
authors.initials: NB
authors.lastname: Li
mesh_terms: D000165:Acridine Orange / Q000737:chemistry*; D052157:Aptamers, Nucleotide / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D054856:G-Quadruplexes; D006108:Graphite / Q000737:chemistry*; D006427:Hemin / Q000032:analysis*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*
chemical_list: D052157:Aptamers, Nucleotide; D005456:Fluorescent Dyes; D010087:Oxides; D006427:Hemin; D006108:Graphite; D004247:DNA; D000165:Acridine Orange