title: Behavior of aqueous nanocrystalline hydroxyapatite in oral bone regeneration.
abstract: OBJECTIVE
  A skeletal segment consisting exclusively of bone is the target outcome of bone regeneration. Granular hydroxyapatites form a hydroxyapatite-bone composite, unsuitable for effectively supporting implants, which may persist for many years. This work aimed to investigate the reasons for the bone replacement of Ostim®, a recently commercialized aqueous nanocrystalline hydroxyapatite.
  
  
  METHODS
  Histology, SEM and X-ray microanalysis were employed to analyze 6- to 9-month biopsies of post-extractive sites or sinus floor lifts of the maxilla in 15 subjects.
  
  
  RESULTS
  The results highlight a great bone formation, Ostim® resorption with time by osteoclasts but also interstitial fluid propagation of Ostim® masses by percolation. A possible osteocyte protoplasmic involvement was also at work in concert to reach the target.
  
  
  CONCLUSIONS
  The use of Ostim® as bone regenerating material leads to the formation of a highly suitable implant support consisting exclusively of bone in less than 12 months, i.e. in a remarkably short time.
authors.affiliation: Department of Biomedical Sciences, Section of Human Morphology, University of Modena and Reggio Emilia, Modena, Italy. davide.zaffe@unimore.it
authors.forename: Davide
authors.initials: D
authors.lastname: Zaffe
authors.forename: Giorgio
authors.initials: G
authors.lastname: Traversa
authors.forename: Marco
authors.initials: M
authors.lastname: Mozzati
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Morelli
authors.forename: Giovanni
authors.initials: G
authors.lastname: D'Angeli
mesh_terms: D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology*; D003460:Crystallization / Q000379:methods; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008422:Materials Testing; D008437:Maxilla / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology*; D008875:Middle Aged; D014867:Water / Q000737:chemistry
chemical_list: D018786:Bone Substitutes; D014867:Water; D017886:Durapatite