title: Credible knowledge: a pilot evaluation of a modified GRADE method using parent-implemented interventions for children with autism.
abstract: BACKGROUND
  Decision-making in child and youth mental health (CYMH) care requires recommendations that are developed through an efficient and effective method and are based on credible knowledge. Credible knowledge is informed by two sources: scientific evidence, and practice-based evidence, that reflects the "real world" experience of service providers. Current approaches to developing these recommendations in relation to CYMH will typically include evidence from one source or the other but do not have an objective method to combine the two. To this end, a modified version of the Grading Recommendations Assessment, Development and Evaluation (GRADE) approach was pilot-tested, a novel method for the CYMH field.
  
  
  METHODS
  GRADE has an explicit methodology that relies on input from scientific evidence as well as a panel of experts. The panel established the quality of evidence and derived detailed recommendations regarding the organization and delivery of mental health care for children and youth or their caregivers. In this study a modified GRADE method was used to provide precise recommendations based on a specific CYMH question (i.e. What is the current credible knowledge concerning the effects of parent-implemented, early intervention with their autistic children?).
  
  
  RESULTS
  Overall, it appeared that early, parent-implemented interventions for autism result in positive effects that outweigh any undesirable effects. However, as opposed to overall recommendations, the heterogeneity of the evidence required that recommendations be specific to particular interventions, based on the questions of whether the benefits of a particular intervention outweighs its harms.
  
  
  CONCLUSIONS
  This pilot project provided evidence that a modified GRADE method may be an effective and practical approach to making recommendations in CYMH, based on credible knowledge. Key strengths of the process included separating the assessments of the quality of the evidence and the strength of recommendations, transparency in decision-making, and the objectivity of the methods. Most importantly, this method combined the evidence and clinical experience in a more timely, explicit and simple process as compared to previous approaches. The strengths, limitations and modifications of the approach as they pertain to CYMH, are discussed.
authors.affiliation: The Provincial Centre of Excellence for Child and Youth Mental Health at CHEO, Ottawa, ON, Canada. mikevanadel@hotmail.com
authors.forename: J Michael
authors.initials: JM
authors.lastname: Van Adel
authors.forename: Jennifer Dunn
authors.initials: JD
authors.lastname: Geier
authors.forename: Adrienne
authors.initials: A
authors.lastname: Perry
authors.forename: Jo-Ann M
authors.initials: JA
authors.lastname: Reitzel
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003657:Decision Making; D055317:Evidence-Based Practice / Q000592:standards*; D006801:Humans; D008605:Mental Health Services; D010287:Parent-Child Relations; D010865:Pilot Projects; D012196:Review Literature as Topic