title: Erythropoiesis, erythropoietin and blood lead levels.
abstract: In a previous study EPO values were significantly lower in exposed subjects (PbB > or =30 mcg/dl) than in controls (PbB" 20 mcg/dl). The aim of the study was to verify if high PbB cause the reduction of EPO in connection with the serum concentration of this hormone expected considering the Hct and hemoglobin (Hb) levels. Both in Pb exposed workers and controls blood levels of EPO, PbB, Hb, Hct were measured. It was not observed any line relation between Hct e log EPO (p = 0.01) and any multiple regression relation between log EPO, Hct and PbB into the total studied population. In our subjects PbB does not change physiologic relation between EPO and Hct and between EPO and Hb. Maybe because normal levels of Hct and Hb reduce EPO production in the healthy population. In physiologic condition of erythropoiesis, EPO does not seem influenced by PbB.
authors.affiliation: Section of Occupational Medicine and Toxicology, University of Siena, Italy. robertaliberatori@inwind.it
authors.forename: Roberta
authors.initials: R
authors.lastname: Liberatori
authors.forename: Riccardo
authors.initials: R
authors.lastname: Romeo
authors.forename: Brunetta
authors.initials: B
authors.lastname: Porcelli
authors.forename: Lucio
authors.initials: L
authors.lastname: Barabesi
authors.forename: Pietro
authors.initials: P
authors.lastname: Sartorelli
mesh_terms: D000328:Adult; D000465:Algorithms; D016022:Case-Control Studies; D004920:Erythropoiesis; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007854:Lead / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D006454:Hemoglobins; D004921:Erythropoietin; D007854:Lead