title: Association between kidney and cardiac diastolic function in Chinese subjects without overt disease: correlation with ageing and inflammatory markers.
abstract: BACKGROUND
  Age-related changes in kidney structure and function have been well documented. This study aimed to assess the relationship between declines of normal ageing-related kidney function and cardiac diastolic function in a healthy Chinese population.
  
  
  METHODS
  A total of 852 healthy adults aged 30-98 years were enrolled and divided into four groups according to quartiles of estimated glomerular filtration rate (eGFR) and cystatin C (CYSC). Cardiac diastolic function was measured by ratio of peak velocity of early filling to peak velocity of atrial filling (E/A), which was derived by B-mode echocardiography. Lower E/A was defined as measures under the 25th percentile of sample distribution (0·784).
  
  
  RESULTS
  Age was significantly associated with eGFR (r = -0·102, P < 0·01), CYSC (r = 0·544, P < 0·01) and E/A (r = -0·381, P < 0·01). Binary logistic regression analysis revealed that second, third and fourth quartile groups of CYSC and fourth quartile of eGFR were significantly associated with lower E/A in an unadjusted model. However, these associations were lost after full adjustment.
  
  
  CONCLUSIONS
  Our results confirm that ageing is a major factor contributing to declines in both kidney and cardiac diastolic function in a healthy population. Adjustment for covariates, however, showed that normal ageing-related declines in kidney function and cardiac diastolic function are not independently linked.
authors.affiliation: Department of Gerontology and Geriatrics, The First Affiliated Hospital of China Medical University, Shenyang, China.
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Han
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Bai
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Lin
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Sun
authors.forename: Xiang-Mei
authors.initials: XM
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D044466:Asian People; D015415:Biomarkers / Q000378:metabolism; D015331:Cohort Studies; D055316:Cystatin C / Q000378:metabolism*; D003971:Diastole / Q000502:physiology; D004452:Echocardiography; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D015415:Biomarkers; D055316:Cystatin C