title: Impact of sleeve gastrectomy on weight loss, glucose homeostasis, and comorbidities in severely obese type 2 diabetic subjects.
abstract: This study was undertaken to assess medium-term effects of laparoscopic sleeve gastrectomy (LSG) on body weight and glucose homeostasis in severely obese type 2 diabetic (T2DM) subjects. Twenty-five obese T2DM subjects (10 M/15 F, age 45 ± 9 years, BMI 48 ± 8 kg/m(2), M ± SD) underwent evaluation of anthropometric/clinical parameters and glucose homeostasis before, 3 and 9-15 months after LSG. Mean BMI decreased from 48 ± 8 kg/m(2) to 40 ± 9 kg/m(2) (P < .001) at 3 months and 34 ± 6 kg/m(2) (P < .001) at 9-15 months after surgery. Remission of T2DM (fasting plasma glucose < 126 mg/dL and HbA1c < 6.5% in the absence of hypoglycemic treatment) occurred in all patients but one. There was a remarkable reduction in the percentage of patients requiring antihypertensive and hypolipidemic drugs. Our study shows that LSG is effective in producing a significant and sustained weight loss and improving glucose homeostasis in severely obese T2DM patients.
authors.affiliation: Department of Clinical and Experimental Medicine, University Federico II, Via A. Pansini 5, 80131 Napoli, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Nosso
authors.forename: L
authors.initials: L
authors.lastname: Angrisani
authors.forename: G
authors.initials: G
authors.lastname: Saldalamacchia
authors.forename: P P
authors.initials: PP
authors.lastname: Cutolo
authors.forename: M
authors.initials: M
authors.lastname: Cotugno
authors.forename: R
authors.initials: R
authors.lastname: Lupoli
authors.forename: G
authors.initials: G
authors.lastname: Vitolo
authors.forename: B
authors.initials: B
authors.lastname: Capaldo