title: A two-component small molecule system for activity-based detection and signal amplification: application to the visual detection of threshold levels of Pd(II).
abstract: A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Baker
authors.forename: Scott T
authors.initials: ST
authors.lastname: Phillips
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D003124:Colorimetry; D007202:Indicators and Reagents / Q000737:chemistry; D057230:Limit of Detection; D010165:Palladium / Q000032:analysis*; D013696:Temperature
chemical_list: D007202:Indicators and Reagents; D010165:Palladium