title: Enucleation and liquid nitrogen cryotherapy in the treatment of keratocystic odontogenic tumors: a case series.
abstract: OBJECTIVE
  This study describes the technique of lesion enucleation without capsule disruption combined with liquid nitrogen cryotherapy in the surgical treatment of keratocystic odontogenic tumors (KOTs).
  
  
  METHODS
  Eight patients (9 KOTs) were included in the study. After enucleation, liquid nitrogen was applied twice for 1 minute, with 5-minute intervals between applications. The patients were followed up for 3 to 9 years.
  
  
  RESULTS
  There were no recurrences during the follow-up of 9 KOTs for up to 9 years. Only 1 patient had temporary reversible loss of lip sensation after treatment. There were no pathologic fractures. In all cases bone height at the surgical site was restored, and no patients needed bone reconstruction for post-treatment rehabilitation.
  
  
  CONCLUSIONS
  This study confirmed the efficiency of KOT treatment enucleation without fragmentation combined with liquid nitrogen cryotherapy at the surgical site.
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Tonietto
authors.forename: Hedelson Odenir Iecher
authors.initials: HO
authors.lastname: Borges
authors.forename: Carlos Alberto Medeiros
authors.initials: CA
authors.lastname: Martins
authors.forename: Daniela Nascimento
authors.initials: DN
authors.lastname: Silva
authors.forename: Manoel
authors.initials: M
authors.lastname: Sant'Ana Filho
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D017679:Cryotherapy; D005260:Female; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000601:surgery / Q000628:therapy*; D008339:Mandibular Neoplasms / Q000601:surgery / Q000628:therapy*; D009584:Nitrogen / Q000008:administration & dosage*; D009807:Odontogenic Cysts / Q000601:surgery / Q000628:therapy*; D009808:Odontogenic Tumors / Q000601:surgery / Q000628:therapy*; D055815:Young Adult
chemical_list: D009584:Nitrogen