title: HGP44 induces protection against Porphyromonas gingivalis-Induced alveolar bone loss in mice.
abstract: The protective effect of DNA vaccines expressing the Arg-gingipain A domain against bone loss induced by Porphyromonas gingivalis infection was investigated in a murine model. phgp44, which expresses the 44-kDa adhesion/hemagglutinin domain of Arg-gingipain A, prevented P. gingivalis-induced alveolar bone loss. The results indicate that phgp44 could be a candidate antigen for a vaccine against P. gingivalis infection.
authors.affiliation: Oral Health Science Center, Tokyo Dental College, Japan.
authors.forename: Kyotaro
authors.initials: K
authors.lastname: Muramatsu
authors.forename: Eitoyo
authors.initials: E
authors.lastname: Kokubu
authors.forename: Takahiko
authors.initials: T
authors.lastname: Shibahara
authors.forename: Katsuji
authors.initials: K
authors.lastname: Okuda
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ishihara
mesh_terms: D018829:Adhesins, Bacterial / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000818:Animals; D003546:Cysteine Endopeptidases / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D005260:Female; D000080867:Gingipain Cysteine Endopeptidases; D051379:Mice; D008807:Mice, Inbred BALB C; D016966:Porphyromonas gingivalis / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*
chemical_list: D018829:Adhesins, Bacterial; D000080867:Gingipain Cysteine Endopeptidases; D019444:Vaccines, DNA; D003546:Cysteine Endopeptidases