title: Mature B-cell neoplasms in Chernobyl clean-up workers of 1986-1987: summary of cytomorphological and immunocytochemical study in 25 years after Chernobyl accident.
abstract: The data on the verified cases of mature B-cell neoplasms (chronic lymphocytic leukemia - CLL, B-prolymphocytic leukemia, non-Hodgkin's lymphoma in leukemization phase and multiple myeloma - MM; 146 cases in total) in the consecutive group of Ukrainian clean-up workers within 10-25 years after Chernobyl accident are summarized. B-cell neoplasms represent the most prevalent group among all diagnosed neoplasms of hematopoietic and lymphoid tissues in clean-up worker patients under study (49.4%). MM percentage in the patients of Chernobyl clean-up worker group turned out to be significantly higher than in the patients of the general populations studied at the same period. While the percentage of B-CLL is similar in clean-up worker patients and patients of general population, the trend towards younger age of patients with mature B-cell neoplasms in clean-up worker group is evident. The current concepts on the possible association between mature B-cell neoplasms (mainly B-CLL) and radiation exposure are briefly outlined. Only the precise diagnosis of hematopoietic malignancies combining with large-scale analytical epidemiological studies with careful dose assessment and long-term follow-up may represent the basis for resolving the question whether mature B-cell neoplasms may be radiogenic.
authors.affiliation: R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine. vals@onconet.kiev.ua
authors.forename: D F
authors.initials: DF
authors.lastname: Gluzman
authors.forename: L M
authors.initials: LM
authors.lastname: Sklyarenko
authors.forename: V A
authors.initials: VA
authors.lastname: Nadgornaya
authors.forename: M P
authors.initials: MP
authors.lastname: Zavelevich
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism; D001402:B-Lymphocytes / Q000473:pathology*; D047852:Chernobyl Nuclear Accident; D019337:Hematologic Neoplasms / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D022423:Myeloid Cells / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology; D014455:Ukraine / Q000453:epidemiology
chemical_list: D000954:Antigens, Surface