title: Association of platelet aggregation with lipid levels in the Japanese population: the Suita study.
abstract: OBJECTIVE
  Platelets play a pivotal role in atherothrombotic diseases. Platelet aggregability induced by agonists has great interindividual variability; however, the factors influencing platelet aggregability variation have not been characterized in Asia.
  
  
  METHODS
  To examine the confounding factors influencing platelet counts and responsiveness to agonists, we measured the platelet counts and platelet aggregability induced by 1.7 µM adenosine diphosphate (ADP) or 1.7 µg/mL collagen using a light transmittance aggregometer in the Japanese general population without medication or cardiovascular disease (387 men and 550 women) in the Suita Study.
  
  
  RESULTS
  Platelet counts were negatively correlated with age in both men and women (Spearman's rank correlation coefficient: r(s)=-0.230 and -0.227; p< 0.01, respectively). In women, platelet counts were correlated negatively with the high-density lipoprotein (HDL) cholesterol level and positively with the low-density lipoprotein (LDL) cholesterol/HDL cholesterol (L/H) ratio (r(s)=-0.135 and 0.119; p< 0.01, respectively). In women, platelet aggregabilities by ADP and collagen were correlated with age (r(s)=0.118 and 0.143; p< 0.01, respectively), and collagen-induced platelet aggregability was correlated with the LDL cholesterol level, the L/H ratio, and the non-HDL cholesterol level (r(s)=0.167, 0.172, and 0.185; p< 0.01, respectively). Even after adjustment for age, systolic blood pressure, body mass index, and current smoking and drinking, the association of platelet counts with the L/H ratio in women and associations of collagen-induced platelet aggregability with the L/H ratio and the non-HDL cholesterol level remained.
  
  
  CONCLUSIONS
  Examination of platelet counts and platelet aggregability induced by ADP and collagen revealed gender, age and lipid levels as factors influencing inter-individual variability.
authors.affiliation: Laboratory of Clinical Chemistry, National Cerebral and Cardiovascular Center, Fujishiro-dai, Suita, Osaka, Japan. skameda@hsp.ncvc.go.jp
authors.forename: Sachika
authors.initials: S
authors.lastname: Kameda
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sakata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kokubo
authors.forename: Mana
authors.initials: M
authors.lastname: Mitsuguro
authors.forename: Akira
authors.initials: A
authors.lastname: Okamoto
authors.forename: Michitaka
authors.initials: M
authors.lastname: Sano
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Miyata
mesh_terms: D000244:Adenosine Diphosphate / Q000737:chemistry / Q000378:metabolism; D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood; D003094:Collagen / Q000378:metabolism; D005260:Female; D006801:Humans; D007564:Japan; D008055:Lipids / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation
chemical_list: D008055:Lipids; D000244:Adenosine Diphosphate; D003094:Collagen