title: Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes.
abstract: It is likely that the C allele of the polymorphism at position -106 in the promoter of aldose reductase gene, which codes a rate-limiting enzyme of the polyol pathway, is a susceptibility allele for diabetic retinopathy in Japanese type 2 diabetic patients.
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. katakami@medone.med.osaka-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Katakami
authors.forename: H
authors.initials: H
authors.lastname: Kaneto
authors.forename: M
authors.initials: M
authors.lastname: Takahara
authors.forename: T A
authors.initials: TA
authors.lastname: Matsuoka
authors.forename: K
authors.initials: K
authors.lastname: Imamura
authors.forename: F
authors.initials: F
authors.lastname: Ishibashi
authors.forename: T
authors.initials: T
authors.lastname: Kanda
authors.forename: K
authors.initials: K
authors.lastname: Kawai
authors.forename: T
authors.initials: T
authors.lastname: Osonoi
authors.forename: M
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: A
authors.initials: A
authors.lastname: Kashiwagi
authors.forename: R
authors.initials: R
authors.lastname: Kawamori
authors.forename: I
authors.initials: I
authors.lastname: Shimomura
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
mesh_terms: D000368:Aged; D000449:Aldehyde Reductase / Q000235:genetics*; D000483:Alleles; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000209:etiology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D000449:Aldehyde Reductase