title: An image-based skeletal dosimetry model for the ICRP reference adult male--internal electron sources.
abstract: In this study, a comprehensive electron dosimetry model of the adult male skeletal tissues is presented. The model is constructed using the University of Florida adult male hybrid phantom of Lee et al (2010 Phys. Med. Biol. 55 339-63) and the EGSnrc-based Paired Image Radiation Transport code of Shah et al (2005 J. Nucl. Med. 46 344-53). Target tissues include the active bone marrow, associated with radiogenic leukemia, and total shallow marrow, associated with radiogenic bone cancer. Monoenergetic electron emissions are considered over the energy range 1 keV to 10 MeV for the following sources: bone marrow (active and inactive), trabecular bone (surfaces and volumes), and cortical bone (surfaces and volumes). Specific absorbed fractions are computed according to the MIRD schema, and are given as skeletal-averaged values in the paper with site-specific values reported in both tabular and graphical format in an electronic annex available from http://stacks.iop.org/0031-9155/56/2309/mmedia. The distribution of cortical bone and spongiosa at the macroscopic dimensions of the phantom, as well as the distribution of trabecular bone and marrow tissues at the microscopic dimensions of the phantom, is imposed through detailed analyses of whole-body ex vivo CT images (1 mm resolution) and spongiosa-specific ex vivo microCT images (30 µm resolution), respectively, taken from a 40 year male cadaver. The method utilized in this work includes: (1) explicit accounting for changes in marrow self-dose with variations in marrow cellularity, (2) explicit accounting for electron escape from spongiosa, (3) explicit consideration of spongiosa cross-fire from cortical bone, and (4) explicit consideration of the ICRP's change in the surrogate tissue region defining the location of the osteoprogenitor cells (from a 10 µm endosteal layer covering the trabecular and cortical surfaces to a 50 µm shallow marrow layer covering trabecular and medullary cavity surfaces). Skeletal-averaged values of absorbed fraction in the present model are noted to be very compatible with those weighted by the skeletal tissue distributions found in the ICRP Publication 110 adult male and female voxel phantoms, but are in many cases incompatible with values used in current and widely implemented internal dosimetry software.
authors.affiliation: Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, FL, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Hough
authors.forename: Perry
authors.initials: P
authors.lastname: Johnson
authors.forename: Didier
authors.initials: D
authors.lastname: Rajon
authors.forename: Derek
authors.initials: D
authors.lastname: Jokisch
authors.forename: Choonsik
authors.initials: C
authors.lastname: Lee
authors.forename: Wesley
authors.initials: W
authors.lastname: Bolch
mesh_terms: D000328:Adult; D001822:Body Burden; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects*; D001842:Bone and Bones / Q000473:pathology / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods* / Q000592:standards; D012016:Reference Values; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000592:standards; D051598:Whole Body Imaging / Q000379:methods* / Q000592:standards