title: Structure-based antivirals for emerging and neglected RNA viruses: an emerging field for medicinal chemistry in academia.
abstract: "Many [neglected viruses] predominantly hit developing countries in tropical and subtropical regions of the world (40% of the world's population are now at risk of contracting dengue fever), but developed countries are by no means immune to their impact."
authors.affiliation: Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. hilgenfeld@biochem.uni-luebeck.de
authors.forename: Rolf
authors.initials: R
authors.lastname: Hilgenfeld
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical / Q000639:trends; D002986:Clinical Trials as Topic; D019049:Developed Countries; D003906:Developing Countries; D015195:Drug Design; D006801:Humans; D007555:Isoxazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010649:Phenylalanine / Q000031:analogs & derivatives; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012327:RNA Virus Infections / Q000188:drug therapy*; D012328:RNA Viruses / Q000187:drug effects* / Q000201:enzymology; D014633:Valine / Q000031:analogs & derivatives
chemical_list: D000998:Antiviral Agents; D007555:Isoxazoles; D011480:Protease Inhibitors; D011760:Pyrrolidinones; D010649:Phenylalanine; D014633:Valine; C118874:rupintrivir