title: A catalytic homo-Nazarov cyclization protocol for the synthesis of heteroaromatic ring-fused cyclohexanones.
abstract: A general protocol for the catalytic homo-Nazarov cyclization of cyclopropyl heteroaryl ketones has been developed, which employs indium triflate as the promoter. A range of heteroaromatic ring-fused cyclohexanones was synthesized in 56-91% yield using this protocol. An example of a tandem cyclopropanation/homo-Nazarov cyclization is also reported in which the one-pot yield is greater than the overall yield of the two individual steps.
authors.affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332, USA.
authors.forename: Lien H
authors.initials: LH
authors.lastname: Phun
authors.forename: Dadasaheb V
authors.initials: DV
authors.lastname: Patil
authors.forename: Marchello A
authors.initials: MA
authors.lastname: Cavitt
authors.forename: Stefan
authors.initials: S
authors.lastname: France
mesh_terms: D002384:Catalysis; D003500:Cyclization; D003512:Cyclohexanones / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D003512:Cyclohexanones