title: The effect of cell-ECM adhesion on signalling via the ErbB family of growth factor receptors.
abstract: Integrins and growth factor receptors of the ErbB family are involved in the regulation of cellular interactions with the extracellular microenvironment. Cross-talk between these two groups of transmembrane receptors is essential for cellular responses and can be regulated through the formation of multimolecular complexes. Tetraspanins as facilitators and building blocks of specialized microdomains may be involved in this process. In the present study, we demonstrated that, in contrast with previous reports, integrin-mediated adhesion did not stimulate ligand-independent activation of ErbB receptors in epithelial cells. However, integrin-dependent adhesion potentiated ligand-induced activation of EGFR (epidermal growth factor receptor) and ErbB2 and facilitated receptor homo- and hetero-dimerization. The actin cytoskeleton appeared to play a critical role in this phenomenon.
authors.affiliation: CRUK Institute for Cancer Studies, School of Cancer Sciences, College for Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
authors.forename: Xanthippi
authors.initials: X
authors.lastname: Alexi
authors.forename: Fedor
authors.initials: F
authors.lastname: Berditchevski
authors.forename: Elena
authors.initials: E
authors.lastname: Odintsova
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000378:metabolism / Q000502:physiology; D005810:Multigene Family / Q000502:physiology; D018739:Oncogene Proteins v-erbB / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D020239:Receptor Cross-Talk / Q000502:physiology; D017978:Receptors, Growth Factor / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: D016023:Integrins; D018739:Oncogene Proteins v-erbB; D017978:Receptors, Growth Factor; D066246:ErbB Receptors