title: First dinuclear Re/Tc complex as a potential bimodal Optical/SPECT molecular imaging agent.
abstract: In this communication, a novel synthetic pathway has been applied to prepare a dual imaging agent in a single molecule. The dinuclear Re(I)/Tc(I) complex 6, namely [Re(CO)(3)(bipy){(4-PyrIDA)Tc(CO)(3)}], is the first example of a Re/Tc-based heterometallic assembly which could act as a potential bimodal Optical/SPECT probe. Interestingly, the Re(I) complex intermediate 4 exhibits significant photophysical properties for biological applications.
authors.affiliation: CNRS; Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique, SPCMIB, UMR 5068, 118, route de Narbonne, F-31062, Toulouse cedex 9, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Boulay
authors.forename: Marine
authors.initials: M
authors.lastname: Artigau
authors.forename: Yvon
authors.initials: Y
authors.lastname: Coulais
authors.forename: Claude
authors.initials: C
authors.lastname: Picard
authors.forename: Béatrice
authors.initials: B
authors.lastname: Mestre-Voegtlé
authors.forename: Eric
authors.initials: E
authors.lastname: Benoist
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013667:Technetium / Q000737:chemistry*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D005456:Fluorescent Dyes; D012211:Rhenium; D013667:Technetium