title: Circulating inflammatory and endothelial markers and risk of hypertension in white and black postmenopausal women.
abstract: BACKGROUND
  Systemic inflammation and endothelial activation are implicated in the development of hypertension. However, epidemiologic studies have yet to compare multiple corresponding biomarkers in relation to risk of hypertension, particularly in multiethnic populations.
  
  
  METHODS
  We identified 800 individuals with incident hypertension and 800 matched controls, each group with equal numbers of white and black women, in a nested case-control study within the Women's Health Initiative Observational Study. We measured markers of inflammation [high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, IL-1β, tumor necrosis factor receptor 2 (TNF-r2)] and endothelial activation [soluble intercellular adhesion molecule-1 (sICAM-1)] in baseline blood samples.
  
  
  RESULTS
  Before adjustment for measures of adiposity, higher hsCRP and IL-6 concentrations were associated with increased risk of hypertension in both white and black women, higher TNF-r2 was associated with increased risk of hypertension in black women only, and IL-1β and sICAM-1 were not associated with risk of hypertension. All the positive associations were attenuated after adjustment for body mass index. The resulting multivariable-adjusted relative risks (95% CI) of hypertension comparing the highest vs lowest quartile were 1.52 (0.94-2.48) and 1.23 (0.76-1.97) for hsCRP and IL-6 in white women and 1.30 (0.81-2.07), 1.58 (0.96-2.59), and 1.49 (0.94-2.36) for hsCRP, IL-6, and TNF-r2 in black women. The results after adjustment for waist circumference were similar.
  
  
  CONCLUSIONS
  After adjustment for measures of adiposity, there was no significant association of hsCRP, IL-6, IL-1β, TNF-r2, or sICAM-1 with incident hypertension in either white or black women. The interrelationships between inflammation and adiposity in development of hypertension need further investigation.
authors.affiliation: Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. luwang@rics.bwh.harvard.edu
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Joann E
authors.initials: JE
authors.lastname: Manson
authors.forename: J Michael
authors.initials: JM
authors.lastname: Gaziano
authors.forename: Simin
authors.initials: S
authors.lastname: Liu
authors.forename: Barbara
authors.initials: B
authors.lastname: Cochrane
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Cook
authors.forename: Paul M
authors.initials: PM
authors.lastname: Ridker
authors.forename: Nader
authors.initials: N
authors.lastname: Rifai
authors.forename: Howard D
authors.initials: HD
authors.lastname: Sesso
mesh_terms: D050154:Adiposity; D001741:Black or African American; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000208:ethnology / Q000209:etiology; D007249:Inflammation / Q000097:blood* / Q000208:ethnology / Q000209:etiology; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D017698:Postmenopause; D011446:Prospective Studies; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D018570:Risk Assessment; D044465:White People
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D015850:Interleukin-6; D047889:Receptors, Tumor Necrosis Factor, Type II; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein