title: Selective recognition of homocysteine and cysteine based on new ruthenium(II) complexes.
abstract: A series of the new ruthenium(II) complexes with different number of aldehyde groups have been synthesized and characterized for the simple and selective sensing of homocysteine (Hcy) and cysteine (Cys). The reaction of these ruthenium(II) complexes with Hcy and Cys afforded thiazinane or thiazolidine derivatives which resulted in the obvious changes in the UV-visible spectra and strong enhancement of the luminescence intensity of the system. The luminescence enhancement of [Ru(dmb)(2)(L2)](2+) (dmb: 4,4'-dimethyl-2,2'-bipyridine) showed a good linearity in the concentration of 4.2-350 μM and 6-385 μM with the detection limits of 0.3 μM and 1 μM for Hcy and Cys, respectively. The absorption and emission bands from metal-to-ligand charge transfer transition in the visible region and the large Stokes shift of the ruthenium(II) complex chromophore made it suitable for biological applications.
authors.affiliation: Key Laboratory of Analysis and Detection Technology for Food Safety, Ministry of Education, Department of Chemistry, Fuzhou University, Fuzhou, China. mjli@fzu.edu.cn
authors.forename: Mei-Jin
authors.initials: MJ
authors.lastname: Li
authors.forename: Chong-Qing
authors.initials: CQ
authors.lastname: Zhan
authors.forename: Mei-Juan
authors.initials: MJ
authors.lastname: Nie
authors.forename: Guo-Nan
authors.initials: GN
authors.lastname: Chen
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
mesh_terms: D002413:Cations, Divalent; D003545:Cysteine / Q000737:chemistry*; D006710:Homocysteine / Q000737:chemistry*; D008163:Luminescent Measurements; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002413:Cations, Divalent; D009942:Organometallic Compounds; D006710:Homocysteine; D012428:Ruthenium; D003545:Cysteine