title: Targeted antimicrobial moieties (WO2010080819): patent evaluation.
abstract: The verification of refined variants of already existing medicines proved to be a breakthrough for antibiotic research. However, resistance to old and newer antibiotics among microbacillary pathogens is evolving quickly. Drug-resistant pathogens have become an important economic burden for patients. This invention (WO2010080819) provides novel targeting moieties (peptides) that specifically/preferentially bind to microorganisms. The targeting moieties can be attached to effectors to form chimeric constructs for specifically/preferentially delivering the effector to and/or into the target organism. In certain embodiments, novel antimicrobial peptides that can be used to inhibit of certain microorganisms are provided.
authors.affiliation: Bioengineering Department, Zhejiang Traditional Chinese Medicine University, Hangzhou 310053, PR China.
authors.forename: Zhong-Cheng
authors.initials: ZC
authors.lastname: Song
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhu
mesh_terms: D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010330:Patents as Topic; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D010455:Peptides