title: OxPL/apoB, lipoprotein(a) and OxLDL biomarkers and cardiovascular disease in chronic hemodialysis patients.
abstract: BACKGROUND
  The aim of this study was to assess the correlation between oxidized phospholipids on apolipoprotein B-100 particles (OxPL/ApoB), lipoprotein(a) and low-density lipoprotein (LDL)-producing oxidized phospholipid (OxLDL) biomarkers and cardiovascular disease (CVD) in chronic hemodialysis (HD) patients.
  
  
  METHODS
  In 52 HD patients, we measured OxPL/apoB by antibody E06, IgG/IgM autoantibody titers to copper-oxidized LDL (Cu-OxLDL) and malondialdehyde (MDA)-LDL, IgG/IgM apolipoprotein B-100-immune complexes (IC/apoB), C-reactive protein (CRP) and lipoprotein(a) (Lp(a)). In all patients, the presence of CVD was assessed.
  
  
  RESULTS
  OxPL/ApoB, IC IgG/IgM, MDA-LDL Ig G/IgM, Cu-OxLDL IgG/IgM and Lp(a) levels were similar in patients with and without CVD. At multiple logistic regression analysis, the association between age and CVD was independent (OR=1.078; 95% confidence interval, 1.005-1.157; p=0.03).
  
  
  CONCLUSIONS
  In HD patients, OxPL/apoB, lipoprotein(a) and OxLDL biomarkers are not associated with CVD.
authors.affiliation: Hemodialysis Service, Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, Rome, Italy. maubosso@tin.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bossola
authors.forename: Luigi
authors.initials: L
authors.lastname: Tazza
authors.forename: Giovanna
authors.initials: G
authors.lastname: Luciani
authors.forename: Antonio
authors.initials: A
authors.lastname: Tortorelli
authors.forename: Sotirios
authors.initials: S
authors.lastname: Tsimikas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000936:Antigen-Antibody Complex / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood*; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007558:Italy; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy*; D017270:Lipoprotein(a) / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016017:Odds Ratio; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010743:Phospholipids / Q000097:blood*; D006435:Renal Dialysis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D000936:Antigen-Antibody Complex; D001055:Apolipoproteins B; D001323:Autoantibodies; D015415:Biomarkers; D017270:Lipoprotein(a); D008077:Lipoproteins, LDL; D010743:Phospholipids; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde; D002097:C-Reactive Protein