title: Congenital isolated leukonychia totalis in three Egyptian sibs.
abstract: Isolated leukonychia totalis is a rare condition of nails with mainly an autosomal dominant pattern of inheritance. In this report, we present three sibs (a sister and two brothers) with isolated congenital leukonychia totalis, without any manifestation among parents and other family members. The sibs had similar facial features and were offspring of consanguineous Egyptian parents. We discussed possible mechanisms of inheritance and suggested an autosomal recessive mode of transmission.
authors.affiliation: Clinical Genetics Department, National Research Centre, Cairo, Egypt. hhafifi@gmail.com
authors.forename: Hanan H
authors.initials: HH
authors.lastname: Afifi
authors.forename: Mahmoud F
authors.initials: MF
authors.lastname: Abdel-Hamid
authors.forename: Maha S
authors.initials: MS
authors.lastname: Zaki
mesh_terms: D000293:Adolescent; D002648:Child; D003241:Consanguinity; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000151:congenital / Q000175:diagnosis / Q000473:pathology; D008297:Male; D009260:Nail Diseases / Q000151:congenital / Q000175:diagnosis / Q000473:pathology; D009262:Nails / Q000473:pathology; D010641:Phenotype; D035781:Siblings