title: [Long-term changes in left ventricular function following intracoronary stem cell transplantation for acute myocardial infarction].
abstract: Controversy surrounds the long-term effects of intracoronary bone marrow stem cell transplantation after ST-elevation acute myocardial infarction (STEAMI). We report on the long-term changes in left ventricular function observed in 29 patients with STEAMI who were treated using this technique. Cardiac magnetic resonance imaging was performed at baseline, 6 months after transplantation, and long-term follow-up (median 27 months, interquartile range 24-35 months). The left ventricular ejection fraction had improved significantly by 6 months (from 47.6 ± 8.9% to 52.7 ± 11.6%; P = .001) and this improvement was maintained long-term, at 52.4 ± 11.8% (P = .01 vs. baseline and P = .999 vs. 6 months). There was no significant change from baseline in end-diastolic or end-systolic ventricular volume. Our findings indicate the improvement in injection fraction occurs soon after stem cell transplantation, within the first 6 months, and remains unchanged at long-term follow-up.
authors.affiliation: Unidad de Imagen Cardiaca (ICICORELAB), Instituto de Ciencias del Corazón (ICICOR), Hospital Clínico Universitario, Valladolid, España. arevillaorodea@gmail.com
authors.forename: Ana
authors.initials: A
authors.lastname: Revilla
authors.forename: Javier
authors.initials: J
authors.lastname: López
authors.forename: Roman
authors.initials: R
authors.lastname: Arnold
authors.forename: Pedro Luis
authors.initials: PL
authors.lastname: Sánchez
authors.forename: Adolfo
authors.initials: A
authors.lastname: Villa
authors.forename: Marta
authors.initials: M
authors.lastname: Pinedo
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernández-Avilés
authors.forename: José Alberto
authors.initials: JA
authors.lastname: San Román
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D000208:Acute Disease; D000368:Aged; D016026:Bone Marrow Transplantation / Q000379:methods*; D003331:Coronary Vessels / Q000502:physiology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000628:therapy*; D010865:Pilot Projects; D016896:Treatment Outcome; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology*