title: [Expressions of FHIT and PTEN and their significance in prostate cancer].
abstract: OBJECTIVE
  To investigate the expressions of the FHIT and PTEN genes and their significance in prostate cancer.
  
  
  METHODS
  The expressions of FHIT and PTEN were detected in 85 cases of prostate cancer and 30 cases of benign prostatic nodular hyperplasia by immunohistochemistry of PV-6000.
  
  
  RESULTS
  The positive expression rates of FHIT and PTEN were 34.1% and 42.4% in prostate cancer, significantly lower than 96.7% and 90.0% in benign prostatic nodular hyperplasia (P <0.01). Statistically significant differences were found in the positive expression rates of FHIT and PTEN among different Gleason grades, 44.4% and 55.6% in well differentiated, 38.9% and 44.4% in moderately differentiated, and 25.0% and 37.5% in lowly differentiated prostate cancer (P <0.05). But the expression of FHIT.
  
  
  CONCLUSIONS
  FHIT and PTEN may play a certain role in the was not correlated with that of PTEN in the prostate cancer tissue (P >0.05). development, progression and infiltration of prostate cancer.
authors.affiliation: Department of Pathology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225001, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xiao
authors.forename: Xue-wen
authors.initials: XW
authors.lastname: Gu
authors.forename: Ji-xin
authors.initials: JX
authors.lastname: Jiang
authors.forename: Cui-mei
authors.initials: CM
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000378:metabolism*; D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D051059:PTEN Phosphohydrolase; D000099170:Bis(5'-adenosyl)triphosphatase; C494929:PTEN protein, human