title: Onoceranoid-type triterpenoids from Lansium domesticum.
abstract: A rare class of onoceranoid-type triterpenoids, represented by lamesticumin A (1), the ethanolysis product of lamesticumin A (2), lamesticumins B-F (3-7), lansic acid 3-ethyl ester (8), and ethyl lansiolate (9), along with four known analogues were isolated from the twigs of Lansium domesticum. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of C-21 in compound 7 was assigned by using Snatzke's method. Compounds 1-9 exhibited moderate antibacterial activity against Gram-positive bacteria.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, People's Republic of China.
authors.forename: Shi-Hui
authors.initials: SH
authors.lastname: Dong
authors.forename: Chuan-Rui
authors.initials: CR
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D029582:Meliaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C560140:lamesticumin A