title: Crosslinking of single-stranded DNA to resins.
abstract: Specific fragments of single-stranded DNA may be covalently immobilized to solid supports for various reasons. The support can be used as an affinity column for purifying DNA from a test sample, to detect viral or bacterial DNAs, or for antenatal diagnosis of genetic diseases such as sickle cell anemia using a sandwich hybridization method developed in this laboratory (1).
authors.affiliation: Department of Biochemistry, Charing Cross and Westminster Medical School, London, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Woodhead
authors.forename: J A
authors.initials: JA
authors.lastname: Langdale
authors.forename: A D
authors.initials: AD
authors.lastname: Malcolm