title: Continuous irrigation with gabexate mesilate around pancreaticojejunostomy after pancreaticoduodenectomy.
abstract: BACKGOUND/AIMS: The aim of this study is to present the new method of continuously irrigated around the pancreaticojejunostomy to reduce postoperative complications after pancreaticoduodenectomy.
  
  
  METHODS
  Twenty-seven patients underwent pancreaticoduodenectomy in our institution between 2002 and 2007. Pancreaticojejunostomy was performed with the external pancreatic duct stent tube, and continuous irrigation around the pancreaticojejunostomy was started on the operative day with physiological saline solution containing gabexate mesilate.
  
  
  RESULTS
  Mean duration of irrigation was 7.1 +/- 4.4 days, mean duration of drainage tube placement was 14.2 +/- 9 days, and mean duration of pancreatic duct drainage tube placement was 24.9 +/- 4.7 days. Pancreatic fistula was diagnosed in 8 patients. Three cases were classified as grade A and 5 cases were grade B. These pancreatic fistulae were closed by non-invasive treatment and the in-hospital death rate was 0%.
  
  
  CONCLUSIONS
  External total drainage of the main pancreatic duct and continuous irrigation around pancreaticojejunostomy appears to avoid severe postoperative complications.
authors.affiliation: Department of Surgery 2, Ehime University School of Medicine, Shitsukawa, Toon 791-0295, Japan. atsushi@m.ehime-u.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Horiuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Kouichi
authors.initials: K
authors.lastname: Sato
authors.forename: Motohira
authors.initials: M
authors.lastname: Yoshida
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugishita
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kameoka
authors.forename: Kanji
authors.initials: K
authors.lastname: Kawachi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004322:Drainage; D005260:Female; D016670:Gabexate / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010185:Pancreatic Fistula / Q000517:prevention & control; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D010193:Pancreaticojejunostomy; D011183:Postoperative Complications / Q000517:prevention & control*; D007507:Therapeutic Irrigation
chemical_list: D016670:Gabexate