title: Predictive factors for prostatic involvement by transitional cell carcinoma of the bladder.
abstract: OBJECTIVE
  To evaluate the predictive factors for prostatic involvement according to the bladder transitional cell carcinoma (TCC) characteristics in a prospective study.
  
  
  METHODS
  Hundred patients with the bladder TCC who had undergone standard radical cystoprostatectomy were enrolled in this study. A number of factors, including vascular and perineural invasion, number of tumors, maximum diameter of the tumor, presence of carcinoma in situ, distance between the tumor and the bladder neck, grade, and local stage of the tumor were recorded, and their relationships with prostatic involvement were studied. In addition, hydronephrosis and age of the patients were included in the analysis.
  
  
  RESULTS
  The mean age of the patients was 62.6 ± 10.8 years. Of a total of 100 patients, 21 (75%) were found to have prostatic involvement with TCC. Univariate statistical analysis showed that vascular invasion and the distance between the tumor and the bladder neck were significantly related to the prostatic involvement (P = .001 and P < .001) and tumor stage had relatively low P value (P = .08). In the logistic regression, only the distance between the tumor and the bladder neck was found to be significantly related to the prostatic involvement (P = .004).
  
  
  CONCLUSIONS
  This study demonstrated that distance between the tumor and the bladder neck is a predictive factor for prostatic involvement; hence, prostate-sparing or capsule-sparing cystectomy in patients with tumors in short distances from prostatovesical junction is not rationale and should be avoided.
authors.affiliation: Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. dralitabibi@gmail.com
authors.forename: Ali
authors.initials: A
authors.lastname: Tabibi
authors.forename: Nasser
authors.initials: N
authors.lastname: Simforoosh
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Parvin
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Abdi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Javaherforooshzadeh
authors.forename: Farhat
authors.initials: F
authors.lastname: Farrokhi
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Soltani
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology*