title: Conference Report: update on ADMET.
abstract: The first day of the conference, run by Select Biosciences, comprised a number of absorption, distribution, metabolism and excretion (ADME) training courses: digital ADME: creating optimized drug candidates from active molecules; exploring reciprocity: dynamic evaluation of ADME properties; hERG: the four commandments; and post rule-of-5 optimization parameters: binding kinetics in lead discovery and optimization. A total of 19 formal conference presentations were given on 24 and 25 February, and effectively covered two broad areas: in vitro and in silico. Several poster presentations were also on display throughout.
authors.affiliation: Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool L33AF, UK. j.c.dearden@ljmu.ac.uk
authors.forename: John C
authors.initials: JC
authors.lastname: Dearden
mesh_terms: D001688:Biological Products / Q000633:toxicity; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels / Q000037:antagonists & inhibitors / Q000378:metabolism; D009152:Mutagenicity Tests; D010599:Pharmacokinetics; D021281:Quantitative Structure-Activity Relationship
chemical_list: D001688:Biological Products; D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels; D003577:Cytochrome P-450 Enzyme System