title: Neuropathology of sleep disorders: a review.
abstract: Sleep disorders are important manifestations of neurodegenerativediseases and sometimes are clinically evident well before the onset of other neurological manifestations. This review addresses theneuroanatomical basis and the mechanisms of sleep regulation in humans in relation to the neuropathology of entities associated with sleep disturbances in selected diseases, including Alzheimer disease, progressive supranuclear palsy, Lewy body disorders, multiple-system atrophy, and fatal familial insomnia. This includes abnormalities of circadian rhythm, insomnia, narcolepsy, rapid eye movements sleep behavior disorders, and excessive daytime sleepiness.
authors.affiliation: APHP, Hôpital de Salpêtrière, Laboratoire de Neuropathologie Raymond Escourolle, UPMC Sorbonne-Universités, CRicm, Inserm UMRS 975, CNRS UMR 7225, Paris, France. jean-jacques.hauw@psl.aphp.fr
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Hauw
authors.forename: Chantal
authors.initials: C
authors.lastname: Hausser-Hauw
authors.forename: Umberto
authors.initials: U
authors.lastname: De Girolami
authors.forename: Dominique
authors.initials: D
authors.lastname: Hasboun
authors.forename: Danielle
authors.initials: D
authors.lastname: Seilhean
mesh_terms: D001683:Biological Clocks; D001921:Brain / Q000473:pathology; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D034062:Insomnia, Fatal Familial / Q000473:pathology; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D009420:Nervous System / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000473:pathology; D009479:Neuropeptides / Q000502:physiology; D000068797:Orexins; D012890:Sleep / Q000502:physiology; D012894:Sleep Stages / Q000502:physiology; D012893:Sleep Wake Disorders / Q000473:pathology*; D012895:Sleep, REM / Q000502:physiology; D014851:Wakefulness / Q000502:physiology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins