title: Evaluation of the effects of type II radical hysterectomy in the treatment of 960 patients with stage IB-IIB cervical carcinoma: A retrospective study.
abstract: OBJECTIVE
  This retrospective study evaluated the feasibility and effectiveness of type II radical hysterectomies alone, or in combination with adjuvant treatment, for the treatment of patients with stage IB-IIB cervical cancer with or without high-risk factors.
  
  
  METHODS
  A total of 960 stage IB-IIB patients who underwent type II radical hysterectomies between 1995 and 2004 were enrolled and retrospectively analyzed.
  
  
  RESULTS
  Uterine corpus invasion, parametrial margin involvement, and pelvic lymph node metastasis were identified as independent prognostic factors for stage IB patients. For stage IIA-IIB patients, histologic type, parametrial margin involvement, and pelvic lymph node metastasis were identified as independent prognostic factors. The 5-year overall survival (OS) rates for patients with stage IB versus stage IIA-IIB cervical carcinomas were 88.4% and 78.5%, respectively. Moreover, adjuvant radiotherapy and chemotherapy improved the 5-year OS rates of stage IIA-IIB patients associated with high-risk factors. The overall recurrence rate for this cohort was 14.4%.
  
  
  CONCLUSIONS
  Our findings show that type II radical hysterectomy is a feasible treatment option for stage IB-IIB cervical carcinoma patients. Furthermore, type II radical hysterectomy combined with adjuvant post-operative therapy improves the OS of women with high-risk factors for cervical carcinoma.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, P. R. China. zheng_min_2006@yahoo.com.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Zheng
authors.forename: Long
authors.initials: L
authors.lastname: Huang
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.forename: Hui-Yun
authors.initials: HY
authors.lastname: Wang
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Zheng
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D018196:Carcinoma, Adenosquamous / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009017:Morbidity; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D055815:Young Adult