title: Steven Kossards postmenopausal frontal fibrosing alopecia (PFFA)--a therapeutic dilemma.
abstract: Steven Kossard described a new type of hair loss that he named frontal postmenopausal fibrosing alopecia (PFFA). In some of his patients he observed a symmetric regression of the frontal hair line. The eyebrows of the patients were also often affected. The histology of the lesions showed lichen planopilaris. Several cases of frontal fibrosing alopecia have been described- almost all of them in elderly women. We report a women with postmenopausal frontal fibrosing alopecia of Kossard. In our patient there were no other clinical signs of lichen planus on the rest of the body After systemic and local therapy with corticosteroids we were able to observe a termination in the disease. In the subsequent 6-month control period no regrowth of the hair follicles was found. Even if there is no proof for a hormonal basis of the disease, the effectiveness of finasteride in some patients may indicate that androgens might be partially responsible of the pathogenesis of the disease. The local and systemic medication with corticosteroids are not able to bring to a permanent remission and secondary growth of the hair follicles in the affected areas and this brings to the necessity of more invasive or innovative therapeutic methods, like skin transplantation and additional application of medicaments like blockers of the 5/alpha reductase, which have proven their capacity in the androgenetic male alopecia.
authors.affiliation: Department of Dermatology, Venereology and Dermatologic Surgery, MVZ Kirchheim, Steingaustrasse 13, 73230 Kirchheim unter Teck, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Tchernev
authors.forename: M
authors.initials: M
authors.lastname: Tronnier
mesh_terms: D000505:Alopecia / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002990:Clobetasol / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D018859:Hair Follicle / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D017698:Postmenopause; D011239:Prednisolone / Q000627:therapeutic use*; D013256:Steroids / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D013256:Steroids; D011239:Prednisolone; D002990:Clobetasol; D008775:Methylprednisolone