title: Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila.
abstract: Thirteen novel PAX (peptide-antimicrobial-Xenorhabdus) peptides were identified in Xenorhabdus nematophila HGB081. Their structures including the absolute configuration were elucidated using a combination of labeling experiments, detailed MS/MS experiments, the advanced Marfey's method, and a detailed analysis of the biosynthesis gene cluster, which was identified as well.
authors.affiliation: Molekulare Biotechnologie, Institut für Molekulare Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
authors.forename: Sebastian W
authors.initials: SW
authors.lastname: Fuchs
authors.forename: Anna
authors.initials: A
authors.lastname: Proschak
authors.forename: Thorsten W
authors.initials: TW
authors.lastname: Jaskolla
authors.forename: Michael
authors.initials: M
authors.lastname: Karas
authors.forename: Helge B
authors.initials: HB
authors.lastname: Bode
mesh_terms: D008239:Lysine / Q000737:chemistry; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry*; D020593:Xenorhabdus / Q000737:chemistry* / Q000378:metabolism
chemical_list: D010456:Peptides, Cyclic; D008239:Lysine