title: The use of superoxidized aqueous solution versus saline as a replacement solution in the versajet lavage system in chronic diabetic foot ulcers: a pilot study.
abstract: BACKGROUND
  The removal of necrotic tissue from chronic wounds is required for wound healing to occur. Hydrodebridement (jet lavage) and superoxidized aqueous solution have been independently used for debriding wounds. We sought to investigate the use of superoxidized aqueous solution with a jet lavage system.
  
  
  METHODS
  Twenty patients with diabetic foot ulcers were randomly assigned in a 1:1 ratio to receive jet lavage debridement with either superoxidized aqueous solution or standard saline weekly.
  
  
  RESULTS
  There was no significant difference between the two treatments in the reduction of bacterial load or wound size in 4 weeks. No adverse reactions were reported for either treatment.
  
  
  CONCLUSIONS
  The use of superoxidized aqueous solution for jet lavage debridement seemed to be as safe and effective as saline. Future investigations should concentrate on whether superoxidized aqueous solution may reduce the bacterial air contamination associated with hydrodebridement.
authors.affiliation: University Department of Medicine and Diabetes, Manchester Royal Infirmary, Manchester, England.
authors.forename: Frank L
authors.initials: FL
authors.lastname: Bowling
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Crews
authors.forename: Eleanna
authors.initials: E
authors.lastname: Salgami
authors.forename: David G
authors.initials: DG
authors.lastname: Armstrong
authors.forename: Andrew J M
authors.initials: AJ
authors.lastname: Boulton
mesh_terms: D000287:Administration, Topical; D002908:Chronic Disease; D017719:Diabetic Foot / Q000188:drug therapy* / Q000473:pathology; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011312:Pressure; D011446:Prospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage*; D013481:Superoxides / Q000008:administration & dosage*; D007507:Therapeutic Irrigation / Q000295:instrumentation*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D013481:Superoxides; D012965:Sodium Chloride