title: The role of increased plasmatic renin level in the pathogenesis of arterial hypertension in young adults.
abstract: BACKGROUND
  Plasma renin level is an important marker of hypertension in the young adults. The purpose of this study was to determine the role of increased levels of plasmatic renin in the pathogenesis of hypertension in young adults and to highlight the main conditions underlying the pathogenesis of hypertension in young people in these circumstances.
  
  
  METHODS
  The group of patients taking part in the study was made of 121 young hypertensive adults (selected from a group of 321 young hypertensive adults), with ages between 18 and 35 years, with elevated blood pressure exceeding 140/90 mmHg in at least three repeated measurements at intervals of one week to exclude white coat phenomenon, or had a blood pressure value greater than 170/100 mmHg at the first measurement and increased plasma renin levels above 4.3 ng/mL.
  
  
  CONCLUSIONS
  Of the 121 young hypertensive patients with increased plasma renin levels, 49 were cases of renal artery stenosis representing 40.50% (p<0.001), eight cases were represented by small unilateral kidneys representing 6.61% (p<0.001), renal cell carcinoma (previously known as "hypernephron" - Grawitz tumor) was responsible for the younger group of patients studied (four cases) representing 3.30% (p<0.001) of the cases of hypertension in the young adults, and 60 cases representing 49.59% were represented by pheochromocytoma.
  
  
  CONCLUSIONS
  The results show the role of plasma renin dosing as being particularly important in the pathogenesis of secondary hypertension in young adults.
authors.affiliation: Department of Internal Medicine, County Hospital of Oradea, Romania. manuela_stoicescu@yahoo.com
authors.forename: Manuela
authors.initials: M
authors.lastname: Stoicescu
authors.forename: C
authors.initials: C
authors.lastname: Csepento
authors.forename: Gabriela
authors.initials: G
authors.lastname: Muţiu
authors.forename: S
authors.initials: S
authors.lastname: Bungău
mesh_terms: D000293:Adolescent; D000328:Adult; D000792:Angiography; D002292:Carcinoma, Renal Cell / Q000097:blood / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology*; D007668:Kidney / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000473:pathology; D007680:Kidney Neoplasms / Q000097:blood / Q000473:pathology; D008279:Magnetic Resonance Imaging; D012078:Renal Artery Obstruction / Q000097:blood / Q000000981:diagnostic imaging; D012083:Renin / Q000097:blood*; D055815:Young Adult
chemical_list: D012083:Renin