title: Necrolytic migratory erythema associated with a metastatic neuroendocrine tumor.
abstract: Necrolytic migratory erythema (NME) is a skin condition historically associated with pancreatic glucagonomas. Rarely it occurs in the absence of a pancreatic tumor, which has been described as pseudoglucagonoma syndrome. We describe a woman with a metastatic neuroendocrine tumor who developed NME 6 years after diagnosis of the tumor. Her laboratory data revealed essential fatty acid deficiency and a high level of glucagon. Although the pathogenesis of NME is not completely understood, zinc, essential amino acid, and fatty acid deficiencies have all been postulated as possible causative factors.
authors.affiliation: Department of Dermatology, Mount Sinai School of Medicine, New York, New York, USA. margarita.lolis@mssm.edu
authors.forename: Margarita S
authors.initials: MS
authors.lastname: Lolis
authors.forename: Anna
authors.initials: A
authors.lastname: Krishtul
authors.forename: Claudia
authors.initials: C
authors.lastname: Vidal
authors.forename: Helen
authors.initials: H
authors.lastname: Shim-Chang
authors.forename: Robert
authors.initials: R
authors.lastname: Phelps
authors.forename: Mark
authors.initials: M
authors.lastname: Lebwohl
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D058568:Necrolytic Migratory Erythema / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D009382:Neoplasms, Unknown Primary / Q000150:complications*; D018358:Neuroendocrine Tumors / Q000150:complications* / Q000556:secondary*