title: Corticosteroids in the treatment of severe nocardia pneumonia in chronic granulomatous disease.
abstract: Nocardia is 1 of the 5 main pathogens that infect chronic granulomatous disease patients. Despite aggressive antimicrobial therapy, medical treatment is not always successful and surgical resection of infected tissue has been intermittently required. We present 2 chronic granulomatous disease patients with severe Nocardia pneumonia whose pulmonary status worsened despite appropriate antimicrobials, but then improved clinically and radiographically with the addition of corticosteroids.
authors.affiliation: Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA. freemaal@niaid.nih.gov
authors.forename: Alexandra F
authors.initials: AF
authors.lastname: Freeman
authors.forename: Beatriz E
authors.initials: BE
authors.lastname: Marciano
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Anderson
authors.forename: Gulbu
authors.initials: G
authors.lastname: Uzel
authors.forename: Christ
authors.initials: C
authors.lastname: Costas
authors.forename: Steven M
authors.initials: SM
authors.lastname: Holland
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D009617:Nocardia Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents