title: [A multicentre retrospective study of pulmonary mycosis clinically proven from 1998 to 2007].
abstract: OBJECTIVE
  To investigate the pathogens, clinical manifestations, prognosis of and the risk factors for pulmonary mycosis in China.
  
  
  METHODS
  All cases of pulmonary mycosis from 16 centers in 10 cities from Jan. 1998 to Dec. 2007 that met the diagnostic criteria were included for clinical, microbiological and radiological analysis.
  
  
  RESULTS
  Totally 474 cases of pulmonary mycosis were retrieved. The top 5 pulmonary mycosis was pulmonary aspergillosis (180 cases, 37.9%), pulmonary candidiasis (162 cases, 34.2%), pulmonary cryptococcosis (74 cases, 15.6%), pneumocystis carinii pneumonia (23 cases, 4.8%) and pulmonary mucormycosis (10 cases, 2.1%). The constituent ratio in the last 3 years was similar to that in the former 7 years. The main pathogens of pulmonary candidiasis were Candida albicans (308/474, 65.0%) and Candida tropicalis (57/474, 12.0%), which were sensitive to common azoles. Compared with bacterial pneumonia, pulmonary mycosis showed more symptoms of hemoptysis (147/474, 31.0%) and pleural effusion (95/474, 20.0%), and less radiological specificity. Classical halo sign (4/474, 0.8%) and crescentic sign (17/474, 3.6%) were only shown in several cases of pulmonary mycosis. The most common underlying diseases were tumor (including solid tumor and malignant hematological diseases) (94/474, 19.8%), chronic obstructive pulmonary disease (52/474, 11.0%), pulmonary tuberculosis (50/474, 10.5%) and diabetes (48/474, 10.1%). Compared with the other common pulmonary mycosis, pulmonary cryptococcosis affected younger patients, and more cases were community-acquired, but fewer cases with underlining diseases or compromised immune function, and had a better prognosis.
  
  
  CONCLUSIONS
  The ahead five species of pulmonary mycosis in China were orderly pulmonary aspergillosis, pulmonary candidosis, pulmonary cryptococcosis, pneumocystis carinii pneumonia and pulmonary mucormycosis. The main pathogens of pulmonary candidosis were Candida albicans and Candida tropicalis, which were sensitive to common azoles. Compared with the other common pulmonary mycosis, pulmonary cryptococcosis catch younger patients, had more community-acquired cases, and had better prognosis.
authors.affiliation: Department of Respiratory Medicine, the General Hospital of Chinese People's Liberation Army, Beijing 100853, China. liuyn301@126.com
authors.forename: You-Ning
authors.initials: YN
authors.lastname: Liu
authors.forename: Dan-Yang
authors.initials: DY
authors.lastname: She
authors.forename: Tie-Ying
authors.initials: TY
authors.lastname: Sun
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Tong
authors.forename: Bei
authors.initials: B
authors.lastname: He
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiao
authors.forename: Li-Xian
authors.initials: LX
authors.lastname: He
authors.forename: Jie-Ming
authors.initials: JM
authors.lastname: Qu
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Liu
authors.forename: Er-Ran
authors.initials: ER
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Zhong-Sen
authors.initials: ZS
authors.lastname: Ma
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Feng
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Jiang
authors.forename: Sheng-Dao
authors.initials: SD
authors.lastname: Xiong
authors.forename: Cheng-Ping
authors.initials: CP
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult