title: Association studies of OGG1, XRCC1, XRCC2 and XRCC3 polymorphisms with differentiated thyroid cancer.
abstract: The role of the DNA repair genes OGG1, XRCC1, XRCC2 and XRCC3 on differentiated thyroid cancer (DTC) susceptibility was examined in 881 individuals (402 DTC and 479 controls). DNA repair genes were proposed as candidate genes, since the current data indicate that exposure to ionizing radiation is the only established factor in the development of thyroid cancer, especially when it occurs in early stages of life. We have genotyped DNA repair genes involved in base excision repair (BER) (OGG1, Ser326Cys; XRCC1, Arg280His and Arg399Gln), and homologous recombination repair (HRR) (XRCC2, Arg188His and XRCC3, ISV-14G). Genotyping was carried out using the iPLEX (Sequenom) technique. Multivariate logistic regression analyses were performed in a case-control study design. From all the studied polymorphism, only a positive association (OR=1.58, 95% CI 1.05-2.46, P=0.027) was obtained for XRCC1 (Arg280His). No associations were observed for the other polymorphisms. No effects of the histopathological type of tumor were found when the DTC patients were stratified according to the type of tumor. It must be emphasized that this study include the greater patients group, among the few studies carried out until now determining the role of DNA repair genes in thyroid cancer susceptibility.
authors.affiliation: Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: Wilser-Andrés
authors.initials: WA
authors.lastname: García-Quispes
authors.forename: Giselle
authors.initials: G
authors.lastname: Pérez-Machado
authors.forename: Abdelmounaim
authors.initials: A
authors.lastname: Akdi
authors.forename: Susana
authors.initials: S
authors.lastname: Pastor
authors.forename: Pere
authors.initials: P
authors.lastname: Galofré
authors.forename: Fina
authors.initials: F
authors.lastname: Biarnés
authors.forename: Joan
authors.initials: J
authors.lastname: Castell
authors.forename: Antonia
authors.initials: A
authors.lastname: Velázquez
authors.forename: Ricard
authors.initials: R
authors.lastname: Marcos
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000235:genetics*; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013964:Thyroid Neoplasms / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C110901:X-ray repair cross complementing protein 3; C000619371:XRCC1 protein, human; C113187:XRCC2 protein, human; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human