title: MYC and metastasis.
abstract: Aggressive primary tumors express transcriptional signatures that correlate with their metastatic propensity. A number of these signatures have been deployed in the clinic as risk stratification tools. However, the molecular basis of these clinically useful prognostic signatures has remained a largely unresolved area of controversy. We recently found that many prognostic signatures reflect the activity of the MYC oncogene, which in turn regulates tumor metastasis through specific effects on cancer cell invasion and migration. These findings offer a general framework for understanding the molecular basis of clinically prognostic transcriptional signatures and suggest potentially new avenues for studying metastasis.
authors.affiliation: Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
authors.forename: Anita
authors.initials: A
authors.lastname: Wolfer
authors.forename: Sridhar
authors.initials: S
authors.lastname: Ramaswamy
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008957:Models, Genetic; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D016271:Proto-Oncogene Proteins c-myc