title: Hepatitis B vaccination during pregnancy for preventing infant infection.
abstract: BACKGROUND
  Infant hepatitis B infection increases risk of chronic infection, cirrhosis or liver cancer (hepatocellular carcinoma) in adult. Perinatal transmission is a common route of infection.
  
  
  OBJECTIVE
  To assess the effectiveness and adverse effects of hepatitis B vaccine administered to pregnant women for preventing hepatitis B virus infection in infants.
  
  
  METHODS
  We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2010).
  
  
  METHODS
  Randomized controlled trials (RCTs) assessing hepatitis B vaccination compared with placebo or no treatment during pregnancy for preventing infant infection. We excluded quasi-RCTs and crossover studies.
  
  
  METHODS
  Two review authors independently assessed trial eligibility.
  
  
  RESULTS
  We were not able to include any studies.
  
  
  CONCLUSIONS
  We found no RCTs that assessed the effects of hepatitis B vaccine during pregnancy for preventing infant infection. Consequently, this review cannot provide guidance for clinical practice in this area. However, it does identify the need for well-designed randomized clinical trials for the effect of hepatitis B vaccine during pregnancy on the incidence of infant infection and adverse effects.
authors.affiliation: Department of Obstetrics and Gynaecology, Khon Kaen Hospital, Srichan Road, Maung, Khon Kaen, Thailand, 40000.
authors.forename: Ussanee S
authors.initials: US
authors.lastname: Sangkomkamhang
authors.forename: Pisake
authors.initials: P
authors.lastname: Lumbiganon
authors.forename: Malinee
authors.initials: M
authors.lastname: Laopaiboon
mesh_terms: D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control* / Q000635:transmission; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D011247:Pregnancy; D014611:Vaccination
chemical_list: D017325:Hepatitis B Vaccines