title: A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.
abstract: A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
authors.affiliation: Basic Research Laboratory, SAIC-Frederick, Maryland, USA. Ping.An@nih.gov
authors.forename: Ping
authors.initials: P
authors.lastname: An
authors.forename: Cheryl
authors.initials: C
authors.lastname: Winkler
authors.forename: Li
authors.initials: L
authors.lastname: Guan
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: O'Brien
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zeng
mesh_terms: D000328:Adult; D044466:Asian People; D002681:China; D005260:Female; D006682:HLA-DP Antigens / Q000235:genetics* / Q000276:immunology*; D059867:HLA-DP alpha-Chains; D006515:Hepatitis B virus / Q000276:immunology* / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D019562:Viral Load
chemical_list: D006682:HLA-DP Antigens; D059867:HLA-DP alpha-Chains; C071172:HLA-DPA1 antigen