title: Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives.
abstract: A series of pegylated distyryl boron dipyrromethenes have been prepared and characterized. Their in vitro photodynamic activities in Tween 80 emulsions have also been investigated against HT29 human colorectal carcinoma cells. The derivative having five triethylene glycol chains (compound 8) exhibits the highest photocytotoxicity with an IC(50) as low as 7 nM. It is also localized preferentially in the endoplasmic reticulum of the cells and can induce predominately apoptosis upon illumination.
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.forename: Pui-Chi
authors.initials: PC
authors.lastname: Lo
authors.forename: Sin-Lui
authors.initials: SL
authors.lastname: Yeung
authors.forename: Wing-Ping
authors.initials: WP
authors.lastname: Fong
authors.forename: Dennis K P
authors.initials: DK
authors.lastname: Ng
mesh_terms: D006801:Humans; D010778:Photochemotherapy; D011092:Polyethylene Glycols / Q000737:chemistry*; D011162:Porphobilinogen / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: C507544:dipyrromethene; D011092:Polyethylene Glycols; D011162:Porphobilinogen