title: Thrombosis associated with acute cytomegalovirus infection: a meta-analysis.
abstract: BACKGROUND
  Thrombosis associated with acute cytomegalovirus (CMV) infection has been reported in the medical literature almost 100 times thus far. Still, the clinical characteristics of patients with both conditions have never been systematically reviewed and described.
  
  
  METHODS
  A literature search was conducted for all (n=97) reports concerning thrombosis associated with acute CMV infection. The current knowledge concerning this unique association and previous clinical experience are presented here.
  
  
  RESULTS
  The incidence of thrombosis among acute CMV infection hospitalized patients was 6.4%, and the incidence of acute CMV infection among thrombosis hospitalized patients was 1.9-9.1%. Most (n=64; 65.9%) reported patients were immunocompetent. Mean age of reported patients was 39.7 ± 14.9 years. Female-male ratio was 1:1. DVT/PE, splanchnic vein thrombosis and splenic infarction were the most prevalent thromboses associated with acute CMV infection. While DVT/PE was more prevalent among immunocompromised patients, splanchnic vein thrombosis was more prevalent among immunocompetent patients. Inherited predispositions for thrombosis were significantly more prevalent among immunocompetent patients. Immunocompromised patients were treated with antiviral agents significantly more often. Duration of anticoagulation therapy varied significantly between reported patients. In-hospital mortality rates were 4.9-22.2%.
  
  
  CONCLUSIONS
  We believe physicians should be alert for symptoms and signs of thrombosis in patients with acute CMV infection, and for symptoms and signs of acute CMV infection in patients with thrombosis.
authors.affiliation: Department of Internal and Geriatric Medicine, Tel-Aviv, Israel. danj@tasmc.health.go.il
authors.forename: Dan
authors.initials: D
authors.lastname: Justo
authors.forename: Talya
authors.initials: T
authors.lastname: Finn
authors.forename: Lihi
authors.initials: L
authors.lastname: Atzmony
authors.forename: Noam
authors.initials: N
authors.lastname: Guy
authors.forename: Arie
authors.initials: A
authors.lastname: Steinvil
mesh_terms: D000208:Acute Disease; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D015994:Incidence; D007297:Inpatients / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013927:Thrombosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology*; D020246:Venous Thrombosis / Q000150:complications / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D000998:Antiviral Agents