title: 1,4-Benzodiazepin-2-ones in medicinal chemistry.
abstract: 1,4-Benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to 'classical' CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones in other areas of medicinal chemistry including uses as G-protein-coupled receptor antagonists, enzyme inhibitors and anticancer agents. Examples from our group will mainly show the use of palladacycle complexes of 1,4-benzodiazepin-2-ones as anticancer agents.
authors.affiliation: School of Science, University of Greenwich at Medway, Chatham, ME4 4TB, UK. j.spencer@gre.ac.uk
authors.forename: John
authors.initials: J
authors.lastname: Spencer
authors.forename: Rajendra P
authors.initials: RP
authors.lastname: Rathnam
authors.forename: Babur Z
authors.initials: BZ
authors.lastname: Chowdhry
mesh_terms: D001569:Benzodiazepines / Q000494:pharmacology*; D006801:Humans
chemical_list: D001569:Benzodiazepines