title: [Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule.
abstract: [Mn(CO)(4){S(2)CNMe(CH(2)CO(2)H)}], 1, is shown to be a CO releasing molecule providing at least three moles CO per mole of compound. The mechanism of CO loss is dissociative and reversible and was investigated using Gaussian 09 calculations. The reversible binding of CO results in a relatively stable solution of the compound, while in the presence of a CO receptor or a ligand to prevent the rebinding of CO, the CO is lost rapidly. The X-ray structure was determined.
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, United Kingdom S3 7HF.
authors.forename: Sian H
authors.initials: SH
authors.lastname: Crook
authors.forename: Brian E
authors.initials: BE
authors.lastname: Mann
authors.forename: Anthony J H M
authors.initials: AJ
authors.lastname: Meijer
authors.forename: Harry
authors.initials: H
authors.lastname: Adams
authors.forename: Philip
authors.initials: P
authors.lastname: Sawle
authors.forename: David
authors.initials: D
authors.lastname: Scapens
authors.forename: Roberto
authors.initials: R
authors.lastname: Motterlini
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000737:chemistry* / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D008345:Manganese / Q000737:chemistry*; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D009942:Organometallic Compounds; D014867:Water; D008345:Manganese; D002248:Carbon Monoxide