title: [Blood transfusion in major orthopaedic surgery].
abstract: Hip and knee surgery is associated with a relatively large bleeding and a need for perioperative transfusion. Postoperative anaemia may delay recovery, but transfusion carries inherent risks. However, only few randomised controlled studies evaluating the effects of different transfusion triggers have been performed in orthopaedic surgery. The majority of these studies suffer from methodological weaknesses and have not been performed in a fast-track setting. Thus, large randomised studies evaluating a restrictive versus a liberal transfusion strategy in a procedure-specific setup are needed.
authors.affiliation: Enhed for Kirurgisk Patofysiologi, 4074, Rigshospitalet, 2100 København Ø, Denmark. oeivind.jans@rh.regionh.dk
authors.forename: Øivind
authors.initials: Ø
authors.lastname: Jans
authors.forename: Henrik
authors.initials: H
authors.lastname: Kehlet
authors.forename: Pär I
authors.initials: PI
authors.lastname: Johansson
mesh_terms: D000740:Anemia / Q000517:prevention & control; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D004434:Early Ambulation; D017707:Erythrocyte Transfusion; D019317:Evidence-Based Medicine; D006801:Humans; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D065227:Transfusion Reaction