title: Involvement of corneodesmosome degradation and lamellar granule transportation in the desquamation process.
abstract: Desquamation in the mammalian skin is a well-balanced process of producing corneocytes and shedding them from the surface of the skin. The corneodesmosome, which is a modified desmosome, is the main adhesive structure in the cornified cell layer. The major extracellular constituents of corneodesmosomes are desmoglein 1, desmocollin 1, and corneodesmosin. Proteases involved in the degradation of corneodesmosomes and their inhibitors are secreted from lamellar granules in the granular cell layer. Genetic defects in corneodesmosin and protease inhibitors result in accelerated desquamation and severe barrier impairment. Abnormalities in transportation and secretion of lamellar granules underlie ichthyosis seen in certain human diseases.
authors.affiliation: Department of Dermatology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, 078-8510, Japan. akemi@asahikawa-med.ac.jp
authors.forename: Akemi
authors.initials: A
authors.lastname: Ishida-Yamamoto
authors.forename: Mari
authors.initials: M
authors.lastname: Kishibe
mesh_terms: D000818:Animals; D001692:Biological Transport; D002403:Cathepsins / Q000037:antagonists & inhibitors / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000648:ultrastructure; D051181:Desmosomal Cadherins / Q000378:metabolism; D003896:Desmosomes / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D000078404:Epidermal Cells; D004817:Epidermis / Q000201:enzymology / Q000648:ultrastructure; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D017490:Ichthyosis, Lamellar / Q000201:enzymology / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins; D007610:Kallikreins / Q000037:antagonists & inhibitors / Q000378:metabolism; D009154:Mutation; D011480:Protease Inhibitors / Q000378:metabolism; D053491:Proteinase Inhibitory Proteins, Secretory / Q000378:metabolism; D000074163:Serine Peptidase Inhibitor Kazal-Type 5
chemical_list: C109656:CDSN protein, human; D051181:Desmosomal Cadherins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D011480:Protease Inhibitors; D053491:Proteinase Inhibitory Proteins, Secretory; C120650:SPINK5 protein, human; D000074163:Serine Peptidase Inhibitor Kazal-Type 5; D002403:Cathepsins; D007610:Kallikreins