title: A modern ionotropic glutamate receptor with a K(+) selectivity signature sequence.
abstract: Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and gates non-selective cation channels. The origins of glutamate receptors are not well understood as they differ structurally and functionally from simple bacterial ligand-gated ion channels. Here we report the discovery of an ionotropic glutamate receptor that combines the typical eukaryotic domain architecture with the 'TXVGYG' signature sequence of the selectivity filter found in K(+) channels. This receptor exhibits functional properties intermediate between bacterial and eukaryotic glutamate-gated ion channels, suggesting a link in the evolution of ionotropic glutamate receptors.
authors.affiliation: Department of Molecular and Cell Biology and the Helen Wills Neuroscience Institute, 271 Life Sciences Addition, University of California, Berkeley, California 94720, USA.
authors.forename: H
authors.initials: H
authors.lastname: Janovjak
authors.forename: G
authors.initials: G
authors.lastname: Sandoz
authors.forename: E Y
authors.initials: EY
authors.lastname: Isacoff
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria; D030541:Databases, Genetic; D015870:Gene Expression; D018698:Glutamic Acid / Q000378:metabolism; D015640:Ion Channel Gating / Q000502:physiology*; D008969:Molecular Sequence Data; D009865:Oocytes / Q000166:cytology / Q000502:physiology; D010802:Phylogeny; D010944:Plants; D011188:Potassium / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D058468:Receptors, Ionotropic Glutamate / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism*; D012403:Rotifera / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D014162:Transfection; D014982:Xenopus laevis
chemical_list: D012333:RNA, Messenger; D058468:Receptors, Ionotropic Glutamate; D011994:Recombinant Proteins; D018698:Glutamic Acid; D011188:Potassium