title: Biosensing using nanoelectromechanical systems.
abstract: Nanoelectromechanical systems (NEMS) correlate analyte-binding events with the mechanical motions of devices in nanometer scales, which in turn are converted into detectable electrical or optical signals. Biosensors based on NEMS have the potential to achieve ultimate sensitivity down to the single-molecule level, provide rapid and real-time detection signals, be operated with extremely low power consumption, and be mass produced with low cost and high reproducibility. This chapter reviews fundamental concepts in NEMS fabrication, actuation and detection, and device characterization, with examples of using NEMS for sensing DNA, proteins, viruses, and bacteria.
authors.affiliation: Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Ashish
authors.initials: A
authors.lastname: Yeri
authors.forename: Di
authors.initials: D
authors.lastname: Gao
mesh_terms: D001419:Bacteria / Q000378:metabolism; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004247:DNA / Q000378:metabolism; D004867:Equipment Design; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation*; D011506:Proteins / Q000378:metabolism; D014780:Viruses / Q000378:metabolism
chemical_list: D011506:Proteins; D004247:DNA