title: [Therapy-related acute myeloid leukemia: role of DNA repair].
abstract: The survival improvement of patients treated with chemotherapy or radiotherapy for malignancies are increasing therapy-related acute myeloid leukemia (t-AML). It was thought to be the direct consequence of genetic events induced by such treatments. We here review the mechanisms of specific chemotherapy-related DNA damage inducing the chromosomal or genomic abnormalities characteristic of t-AML. We also focus on how such aberrations could initiate or participate to leukemogenesis. However, only a part of patients exposed to cytotoxic therapy is developing t-AML, suggesting that some genetic predisposition may be involved such as polymorphisms in genes related to DNA repair.
authors.affiliation: Université Clermont-I, Clermont-Ferrand, France. rguieze@chu-clermontferrand.fr
authors.forename: Romain
authors.initials: R
authors.lastname: Guièze
authors.forename: Aurélie
authors.initials: A
authors.lastname: Ravinet
authors.forename: Eric
authors.initials: E
authors.lastname: Hermet
authors.forename: Yassine
authors.initials: Y
authors.lastname: Maliki
authors.forename: Stéphane
authors.initials: S
authors.lastname: de Botton
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Bay
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D004247:DNA / Q000187:drug effects / Q000235:genetics; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics / Q000502:physiology*; D042822:Genomic Instability / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000235:genetics*; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D004247:DNA