title: Sex differences in drug disposition.
abstract: Physiological, hormonal, and genetic differences between males and females affect the prevalence, incidence, and severity of diseases and responses to therapy. Understanding these differences is important for designing safe and effective treatments. This paper summarizes sex differences that impact drug disposition and includes a general comparison of clinical pharmacology as it applies to men and women.
authors.affiliation: Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA. os35@georgetown.edu
authors.forename: Offie P
authors.initials: OP
authors.lastname: Soldin
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Chung
authors.forename: Donald R
authors.initials: DR
authors.lastname: Mattison
mesh_terms: D000042:Absorption; D000701:Analgesics, Opioid / Q000378:metabolism / Q000494:pharmacology; D000758:Anesthesia; D001682:Biological Availability; D001823:Body Composition; D002302:Cardiac Output; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D057285:Precision Medicine; D012737:Sex Factors
chemical_list: D000701:Analgesics, Opioid; D002352:Carrier Proteins; D012739:Gonadal Steroid Hormones; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System