title: Organellar calcium buffers.
abstract: Ca(2+) is an important intracellular messenger affecting many diverse processes. In eukaryotic cells, Ca(2+) storage is achieved within specific intracellular organelles, especially the endoplasmic/sarcoplasmic reticulum, in which Ca(2+) is buffered by specific proteins known as Ca(2+) buffers. Ca(2+) buffers are a diverse group of proteins, varying in their affinities and capacities for Ca(2+), but they typically also carry out other functions within the cell. The wide range of organelles containing Ca(2+) and the evidence supporting cross-talk between these organelles suggest the existence of a dynamic network of organellar Ca(2+) signaling, mediated by a variety of organellar Ca(2+) buffers.
authors.affiliation: Department of Biochemistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Prins
authors.forename: Marek
authors.initials: M
authors.lastname: Michalak
mesh_terms: D000818:Animals; D002021:Buffers; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D037282:Calreticulin; D000091342:Endoplasmic Reticulum Chaperone BiP; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D006801:Humans; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D051379:Mice; D008954:Models, Biological; D015388:Organelles / Q000378:metabolism*; D019704:Protein Disulfide-Isomerases
chemical_list: D002021:Buffers; D037282:Calreticulin; D000091342:Endoplasmic Reticulum Chaperone BiP; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C062477:endoplasmic reticulum glycoprotein p72; C018551:glucose-regulated proteins; D019704:Protein Disulfide-Isomerases; D002118:Calcium