title: Construction of a hyperbranched supramolecular polymer as a bifunctional antioxidative enzyme model.
abstract: A HBSP has been designed as a novel bifunctional enzyme model with SOD and GPx activity by host/guest-directed self-assembly of MnTPyP-M-Ad and 6-Te-diCD. The structure of the host/guest complex was elucidated by (1) H NMR spectra, and the HBSP was characterized by SEM, DLS and measurement of catalytic properties. In the bifunctional enzyme model, the Mn(III) porphyrins act as efficient SOD active sites and the tellurol moieties endow GPx activity. The SOD-like activity (IC(50) ) of this new supramolecular catalyst was found to be 1.05 × 10(-7) M, which corresponds to 2.82% of the activity of the native SOD enzyme. Besides this, the hyperbranched supramolecular polymer also shows a higher GPx activity (ν(0 ) = 21.7 × 10(-6) M · min(-1) ) than other supramolecular enzyme models.
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, China.
authors.forename: Shuangjiang
authors.initials: S
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Junyan
authors.initials: J
authors.lastname: Zhu
authors.forename: Yanzhen
authors.initials: Y
authors.lastname: Yin
authors.forename: Haiyan
authors.initials: H
authors.lastname: Jin
authors.forename: Lipeng
authors.initials: L
authors.lastname: Zhou
authors.forename: Quan
authors.initials: Q
authors.lastname: Luo
authors.forename: Jiayun
authors.initials: J
authors.lastname: Xu
authors.forename: Junqiu
authors.initials: J
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000378:metabolism*; D057005:Bioengineering / Q000379:methods*; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000378:metabolism; D002374:Catalase / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis; D020134:Catalytic Domain; D005979:Glutathione Peroxidase / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D008345:Manganese / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011108:Polymers / Q000138:chemical synthesis / Q000378:metabolism*; D011166:Porphyrins / Q000737:chemistry; D013482:Superoxide Dismutase / Q000737:chemistry / Q000378:metabolism*; D013691:Tellurium / Q000737:chemistry
chemical_list: D000975:Antioxidants; D011108:Polymers; D011166:Porphyrins; D008345:Manganese; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D013691:Tellurium