title: Hydrogel templates for the fabrication of homogeneous polymer microparticles.
abstract: Nano/microparticulate drug delivery systems with homogeneous size distribution and predefined shape are important in understanding the influence of the geometry and dimensions of these systems on blood circulation times and cellular uptake. We present a general method using water dissolvable hydrogel templates for the fabrication of homogeneous, shape-specific polymer/drug constructs in the size range of 200 nm to 50 μm. This hydrogel template strategy is mild, inexpensive, and readily scalable for the fabrication of multifunctional drug delivery vehicles.
authors.affiliation: Department of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
authors.forename: Ghanashyam
authors.initials: G
authors.lastname: Acharya
authors.forename: Matthew
authors.initials: M
authors.lastname: McDermott
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Shin
authors.forename: Haesun
authors.initials: H
authors.lastname: Park
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods; D004867:Equipment Design; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry / Q000378:metabolism; D055616:Microtechnology / Q000295:instrumentation* / Q000379:methods*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry / Q000378:metabolism; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011100:Polyglycolic Acid; D019344:Lactic Acid