title: The Influence of Flightless I: regeneration versus wound healing.
abstract: The molecular mechanisms involved in organ regeneration has biomedical implications in regenerative medicine. In this issue, Waters et al. demonstrate that levels of the established negative wound healing factor Flightless I (Flii) modulate the hair follicle's capacity to regenerate a fiber-forming bulb after amputation. Still to be investigated are the specific pathways through which Flii influences regeneration as compared with wound healing.
authors.affiliation: Developmental Skin Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. morassom@mail.nih.gov
authors.forename: Maria I
authors.initials: MI
authors.lastname: Morasso
mesh_terms: D000818:Animals; D018859:Hair Follicle / Q000502:physiology*; D006801:Humans; D008840:Microfilament Proteins / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D015534:Trans-Activators; D014945:Wound Healing / Q000502:physiology*
chemical_list: C098179:FLII protein, human; D008840:Microfilament Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators