title: Distribution of antiseptic resistance genes qacA, qacB, and smr in methicillin-resistant Staphylococcus aureus isolated in Toronto, Canada, from 2005 to 2009.
abstract: Decreased susceptibility to chlorhexidine gluconate (CHDN) in methicillin-resistant Staphylococcus aureus (MRSA) is associated with the qacA, qacB, and smr genes, encoding efflux pumps. A total of 334 MRSA isolates were collected from two Canadian intensive care units between 2005 and 2009. We identified the qacAB genes in 7 strains (2%; 2 qacA genes and 5 qacB genes) and the smr gene in 23 (7%) strains. CHDN minimal bactericidal concentrations were slightly higher for strains harboring smr genes.
authors.affiliation: Infectious Disease Research Center, Laval University, 2750 Laurier Blvd., Quebec City, Quebec G1V 4G2, Canada. jean.longtin@CRCHUQ.ULaval.ca
authors.forename: Jean
authors.initials: J
authors.lastname: Longtin
authors.forename: Christine
authors.initials: C
authors.lastname: Seah
authors.forename: Krystal
authors.initials: K
authors.lastname: Siebert
authors.forename: Allison
authors.initials: A
authors.lastname: McGeer
authors.forename: Andrew
authors.initials: A
authors.lastname: Simor
authors.forename: Yves
authors.initials: Y
authors.lastname: Longtin
authors.forename: Donald E
authors.initials: DE
authors.lastname: Low
authors.forename: Roberto G
authors.initials: RG
authors.lastname: Melano
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D017920:Antiporters / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D002170:Canada; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D026901:Membrane Transport Proteins / Q000235:genetics*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D013997:Time Factors
chemical_list: D000891:Anti-Infective Agents, Local; D017920:Antiporters; D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; C099272:QacB protein, Staphylococcus aureus; C521590:small multidrug-resistance pump, Staphylococcus aureus; C068498:qacA protein, Staphylococcus aureus; C010882:chlorhexidine gluconate; D002710:Chlorhexidine