title: [Baker's asthma. Experimental studies].
abstract: Baker's asthma is one of the most commonly reported occupational lung diseases in countries, and is characterized by rhinitis, bronchial hyperresponsiveness, and reversible airflow obstruction. The development of a mouse model could be useful in order to characterize the development and progression of baker's asthma.
  
  
  RESULTS
  Experimental studies evidenced that flour dust elicits neutrophilic inflammation in a tlr4-independent manner, suggesting that endotoxin is not playing a role in the inflammatory response to flour dust. Moreover, bakery flour dust and dust extract significantly enhance pre-existing allergic asthma in OVA sensitized and challenged mice.
  
  
  CONCLUSIONS
  Bakery flour dust is strongly pro-inflammatory, can cause non-allergic airway inflammation, and can enhance allergen-mediated airway inflammation.
authors.affiliation: Centro di Allergologia Ambientale, Dipartimento di Medicina del Lavoro, Ospedale Maggiore Policlinico-Milano. paolo.marraccini@policlinico.mi.it
authors.forename: P
authors.initials: P
authors.lastname: Marraccini
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D016535:Bronchial Hyperreactivity / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D004391:Dust / Q000276:immunology; D005433:Flour / Q000009:adverse effects*; D007249:Inflammation / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology; D012137:Respiratory System / Q000276:immunology; D051197:Toll-Like Receptor 4 / Q000276:immunology
chemical_list: D000485:Allergens; D004391:Dust; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; D010047:Ovalbumin