title: Learning from the 2009 H1N1 pandemic: prospects for more broadly effective influenza vaccines.
abstract: Calls to develop a universal influenza vaccine have increased in the wake of the 2009 H1N1 influenza pandemic. This demand comes at a time when analyses of the human antibody repertoire, informed by structures of complexes between broadly neutralizing antibodies and influenza hemagglutinin, have revealed the target of a class of broadly neutralizing antibodies. Recent studies suggest a path forward to more broadly protective influenza vaccines.
authors.affiliation: Novartis Vaccines and Diagnostics, Cambridge, MA, USA.
authors.forename: Ethan C
authors.initials: EC
authors.lastname: Settembre
authors.forename: Philip R
authors.initials: PR
authors.lastname: Dormitzer
authors.forename: Rino
authors.initials: R
authors.lastname: Rappuoli
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D019143:Evolution, Molecular; D040961:Genetic Drift; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology; D006801:Humans; D007114:Immunization; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control*; D058873:Pandemics
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D000956:Antigens, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines