title: An adult case of melanotic Xp11 translocation renal cancers: distinct entity or sub-entity?
abstract: Melanotic Xp11 translocation renal cancer is a recently recognized aggressive epithelioid neoplasm with features overlapping between PEComa, carcinoma, and melanoma, in which TFE3 gene fusions coexist with melanin synthesis. These findings support the idea that melanotic Xp11 translocation renal cancer is a distinct variant of the MiT/TFE3 family neoplasms. The authors describe a pigmented renal tumor occurring in a 30-year-old woman with distinct morphology and immunohistochemical characteristics as Xp11 translocation renal cancer.
authors.affiliation: Service d'Anatomie Pathologique, Hôpital La Pitié Salpêtrière, Université Pierre et Marie Curie, Paris, France. justinevarinot@hotmail.com
authors.forename: Justine
authors.initials: J
authors.lastname: Varinot
authors.forename: Philippe
authors.initials: P
authors.lastname: Camparo
authors.forename: Sylvain
authors.initials: S
authors.lastname: Beurtheret
authors.forename: Eleodoro
authors.initials: E
authors.lastname: Barreda
authors.forename: Eva
authors.initials: E
authors.lastname: Compérat
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D041321:Chromosomes, Human, X; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D009392:Nephrectomy; D014178:Translocation, Genetic