title: Preparation of meloxicam-β-cyclodextrin-polyethylene glycol 6000 ternary system: characterization, in vitro and in vivo bioavailability.
abstract: Ternary complexes of meloxicam (ML), a poorly water-soluble anti-inflammatory drug, with β-cyclodextrin (βCD) and polyethylene glycol (PEG) 6000 were prepared from an equimolar (ML-βCD) and 10% of PEG. Characterization of the ternary complex was carried out by differential scanning calorimetry and X-ray diffractometry. The solubility of ML increased as a function of increasing the concentration of βCD and PEG 6000. Ternary system increased significantly ML solubility in water. Ternary complexes improved drug release compared with ML and ML-βCD. The oral bioavailability of ML-βCD-PEG was investigated by administration to rat and compared with ML and ML-βCD. The results confirmed that the oral bioavailability of ML was significantly improved by complexation with βCD in the presence of PEG.
authors.affiliation: Laboratoire de chromatographie, Faculté de chimie, El-Alia, Bab-Ezzouar, Alger, Algeria.
authors.forename: Ourezki
authors.initials: O
authors.lastname: Radia
authors.forename: Ewa
authors.initials: E
authors.lastname: Rogalska
authors.forename: Guermouche
authors.initials: G
authors.lastname: Moulay-Hassane
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000097:blood* / Q000737:chemistry; D001682:Biological Availability; D004337:Drug Carriers / Q000737:chemistry; D000077239:Meloxicam; D011092:Polyethylene Glycols / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013843:Thiazines / Q000008:administration & dosage* / Q000097:blood* / Q000737:chemistry; D013844:Thiazoles / Q000008:administration & dosage* / Q000097:blood* / Q000737:chemistry; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D013843:Thiazines; D013844:Thiazoles; D047392:beta-Cyclodextrins; D011092:Polyethylene Glycols; C031215:betadex; D000077239:Meloxicam