title: In vivo imaging neurotransmitter function. The rat 6-hydroxydopamine model and its relevance for human Parkinson's disease.
abstract: This article gives an overview of those small animal imaging studies which have been conducted on neurotransmitter function in the rat 6-hydoxydopamine (6-OHDA) model of Parkinson's disease, and discusses findings with respect to the outcome of clinical studies on Parkinsonian patients.
authors.affiliation: Clinic of Nuclear Medicine, University Hospital Düsseldorf, 40225 Düsseldorf, Germany. Susanne.Nikolaus@uni-duesseldorf.de
authors.forename: S
authors.initials: S
authors.lastname: Nikolaus
authors.forename: R
authors.initials: R
authors.lastname: Larisch
authors.forename: H
authors.initials: H
authors.lastname: Vosberg
authors.forename: M
authors.initials: M
authors.lastname: Beu
authors.forename: H
authors.initials: H
authors.lastname: Hautzel
authors.forename: A
authors.initials: A
authors.lastname: Wirrwar
authors.forename: H-W
authors.initials: HW
authors.lastname: Mueller
authors.forename: C
authors.initials: C
authors.lastname: Antke
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D014018:Tissue Distribution
chemical_list: D018377:Neurotransmitter Agents; D016627:Oxidopamine