title: [Diabetes mellitus and Alzheimer's disease].
abstract: The incidence of Alzheimer's disease and diabetes is increasing with age. Thus, in light of demographic change and aging societies, they are becoming a growing issue for public health. Further, there are linkages between the two diseases. In particular, risk assessment studies suggest that type 2 diabetes mellitus is a risk factor of Alzheimer's disease. Hence, even though Alzheimer's disease can only be influenced to a limited extent, optimal treatment of diabetes mellitus may have also a positive effect on Alzheimer's disease. While the relationship between the two diseases is not yet completely clear, in addition to the known vascular effects of diabetes mellitus recent results shed light on central nervous system effects directly influencing the neurodegenerative process. Treatment of central insulin resistance, a phenomenon explored in recent years, may be a promising avenue, not only in addressing metabolic disorder, but also Alzheimer's disease.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Pszichiátriai és Pszichoterápiás Klinika Budapest Balassa u. 6. 1083. salacz@psych.sote.hu
authors.forename: Pál
authors.initials: P
authors.lastname: Salacz
authors.forename: Eva
authors.initials: E
authors.lastname: Csibri
mesh_terms: D000367:Age Factors; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000378:metabolism* / Q000523:psychology / Q000628:therapy; D003071:Cognition; D015897:Comorbidity; D048909:Diabetes Complications / Q000453:epidemiology* / Q000378:metabolism* / Q000523:psychology / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000378:metabolism* / Q000628:therapy; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D011157:Population Dynamics; D011634:Public Health / Q000639:trends; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D017127:Glycation End Products, Advanced