title: [The effects of combination anti-inflammatory and anti-oxidation drugs in acute stroke].
abstract: OBJECTIVE
  Research the effect of anti-inflammatory and anti-oxidation drugs on acute stroke patients.
  
  
  METHODS
  128 patients with acute ischemic stroke are divided into two groups-combined treatment group (71) and control (57). Test serum biomarkers and evaluate neurological function and living ability before and after therapy, compare between groups and intra-group. To observe the effects of combined therapy on serum biomarkers and prognosis in acute stage.
  
  
  RESULTS
  (1) MMP-9 of combined treatment group (3.23 ± 0.99) ng/L is higher than control (2.82 ± 1.21) ng/L before therapy (P < 0.05). (2) The level of pre-treatment ox-LDL-Ab in combined treatment group (0.08 ± 0.01) U/ml higher than post-treatment (0.07 ± 0.01) U/ml (P < 0.05). The level of pre-treatment NIHSS in control group (5.76 ± 6.61) score higher than post-treatment (4.22 ± 5.45) score, P < 0.05.
  
  
  CONCLUSIONS
  Combined treatment can degrade serum MMP-9 and ox-LDL in acute ischemic stroke patients, but it can't obviously improve the earlier prognosis.
authors.affiliation: Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. biqidoctor@163.com
authors.forename: Qi
authors.initials: Q
authors.lastname: Bi
authors.forename: Zhe
authors.initials: Z
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D020521:Stroke / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein; D020780:Matrix Metalloproteinase 9