title: Wilms tumor: five-year tumor-free survival on a modified SIOP protocol from an Indian university hospital.
abstract: OBJECTIVE
  Wilms tumor is one of the most common solid malignancies of childhood. The long-term result of the surgical treatment of this tumor with adjuvant chemotherapy and radiation has been reported from many western centers. However, there is paucity of literature on the long-term outcome of treatment for this tumor from the developing world. We planned a prospective study that started in 1999 to evaluate the 5-year tumor-free survival of Wilms tumor treated on a fixed protocol from a university hospital in India.
  
  
  METHODS
  All consecutive children with Wilms tumor who were seen by any of the 3 investigators (2 pediatric oncologists, 1 pediatric surgeon) between 1999 and 2003 at the Advanced Pediatric Centre were included in the study. Each patient was entered into a database. Their demographic profile and events during the treatment and follow-up were recorded. This was later analyzed.
  
  
  CONCLUSIONS
  Seventy-five percent 5-year tumor-free survival has been achieved within the limitations of treatment in the developing world. The morbidity during therapy was 10% and the mortality 5%. This was based on the treatment of this common childhood malignancy at Chandigarh on a modified International Society of Pediatric Oncology protocol.
authors.affiliation: Division of Paediatric Haematology Oncology, Advanced Paediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. trehanamita@hotmail.com
authors.forename: Amita
authors.initials: A
authors.lastname: Trehan
authors.forename: Sujit K
authors.initials: SK
authors.lastname: Chowdhary
authors.forename: Ram K
authors.initials: RK
authors.lastname: Marwaha
mesh_terms: D044963:Biopsy, Fine-Needle; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D011446:Prospective Studies; D015996:Survival Rate; D009396:Wilms Tumor / Q000401:mortality* / Q000473:pathology / Q000628:therapy