title: [Chronic exposure to organochlorine compounds and health effects in adults: cancer, non-Hodgkin lymphoma. Review of literature].
abstract: International Agency for Research on Cancer (IARC) has classified 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) as human multisite carcinogen though not associated to specific tumours. Other dioxins and furans are not classified as carcinogenic due to lack of scientific evidence, and polychlorobiphenyls (PCBs) are classified as probable carcinogens. The aim of this research is to focus the association between chronic exposure to organochlorine compounds and cancer in adults. We included cohort studies among occupationally exposed workers or in populations exposed to high levels of these chemicals in the environment, and cohort and case-control studies using measure of internal dose of exposure. Overall, cohort studies among heavy exposed people do not show an increased risk of developing cancer and do not show consistent results as regards in specific sites neoplasms. Among epidemiologic analytical studies with individual measures of exposure, most, though not all, found an association between Non-Hodgkin lymphoma and PCB serum level concentrations. Weak evidence, if any, was available as regards the association between organochlorine compounds and other cancers.
authors.affiliation: Dipartimento di Medicina Sperimentale ed Applicata, Sezione di Igiene, Epidemiologia e Sanità Pubblica, Università degli Studi di Brescia. donato@med.unibs.it
authors.forename: F
authors.initials: F
authors.lastname: Donato
authors.forename: C
authors.initials: C
authors.lastname: Zani
mesh_terms: D000328:Adult; D002273:Carcinogens / Q000633:toxicity*; D015331:Cohort Studies; D019317:Evidence-Based Medicine; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D007558:Italy / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000453:epidemiology*; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D018570:Risk Assessment
chemical_list: D002273:Carcinogens; D006843:Hydrocarbons, Chlorinated