title: Contributions to the study of morphofunctional interrelations in the liver of the rats treated with certain antipsychotic drugs.
abstract: The issue of antipsychotics in psychiatry constituted a revolution at the time. The firsts, starting with chlorpromazine represent the conventional antipsychotics, in the last decades there was a new generation of antipsychotics, atypical, which improved the results in treating psychoses. Because, as any drug, it may have adverse effects we aimed an experimental study on rats to observe the toxic potential on liver of both generations of antipsychotics. From the first generation we used chlorpromazine, haloperidol and haloperidol decanoate and from the second, aripiprazole and risperidone. Results of the study show an increased toxicity of chlorpromazine and diminished among the others, without being the same for every drug.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania. bogdan.maria81@yahoo.com
authors.forename: Maria
authors.initials: M
authors.lastname: Bogdan
authors.forename: Florica
authors.initials: F
authors.lastname: Popescu
authors.forename: Fl
authors.initials: F
authors.lastname: Bogdan
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018967:Risperidone / Q000494:pharmacology
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol; D018967:Risperidone; D002746:Chlorpromazine