title: Cytomorphologic features of chondroid neoplasms: a comparative study.
abstract: OBJECTIVE
  To perform a comparative analysis of fine needle aspiration cytology (FNAC) features of chondroid tumors and their significance in diagnosis.
  
  
  METHODS
  A retrospective evaluation of 17 chondroid tumors diagnosed by FNAC was done. Cytologic features were detailed and compared among different chondroid tumor types and with available histology.
  
  
  RESULTS
  The 17 cases comprised enchondroma (5), osteochondroma (1), chondroblastoma (2), chondromyxoid fibroma (2) and chondrosarcoma (7). Chondroblastoma and chondromyxoid fibroma were specifically diagnosed in all 4 cases by FNAC due to characteristic cytology. However, the cytologic appearance of enchondromas overlapped significantly with that of well-differentiated chondrosarcoma, but the correct diagnosis was made by interpreting cytology with clinicoradiologic correlation. The cytologic features of high chondroid fragment cellularity, irregular cell arrangement in fragments, prominent nucleoli, and moderate to severe nuclear hyperchromasia and mitotic activity were limited to chondrosarcoma. The single error consisted of a case of osteogenic sarcoma, chondroblastic type, that was interpreted as chondrosarcoma.
  
  
  CONCLUSIONS
  FNAC smears interpreted in the light of clinical and radiologic findings demonstrated high diagnostic accuracy. It is important to be aware of the cytology of uncommon chondroid tumors such as chondroblastoma and chondromyxoid fibroma as well as of the overlap of cytologic features between enchondroma and chondrosarcoma to avoid diagnostic pitfalls.
authors.affiliation: Department of Pathology, Government Medical Clege and Hospital, Chandigarh, India. drseemachhabra@rediffmail.com
authors.forename: Seema
authors.initials: S
authors.lastname: Chhabra
authors.forename: Rajan
authors.initials: R
authors.lastname: Chopra
authors.forename: Uma
authors.initials: U
authors.lastname: Handa
authors.forename: Rajpal Singh
authors.initials: RS
authors.lastname: Punia
authors.forename: Harsh
authors.initials: H
authors.lastname: Mohan
mesh_terms: D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002804:Chondroblastoma / Q000000981:diagnostic imaging / Q000473:pathology; D002812:Chondroma / Q000000981:diagnostic imaging / Q000473:pathology; D002813:Chondrosarcoma / Q000000981:diagnostic imaging / Q000473:pathology; D003951:Diagnostic Errors; D005260:Female; D005350:Fibroma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000000981:diagnostic imaging / Q000473:pathology*; D015831:Osteochondroma / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012189:Retrospective Studies; D055815:Young Adult