title: ERRs and cancers: effects on metabolism and on proliferation and migration capacities.
abstract: ERRs are orphan members of the nuclear receptor superfamily which, at least for ERRα and ERRγ display important roles in the control of various metabolic processes. On other hand, correlations have been found between the expression of ERRα and γ and diverse parameters of tumor progression in human cancers. Whereas it is tempting to speculate that ERR receptors act in tumors through the regulation of metabolism, recent data have suggested that they also may directly regulate tumor proliferation and progression independently of their effects on metabolism. The two aspects of tumoral functions of ERR receptors are the purpose of the present review.
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon cedex 07, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bianco
authors.forename: Juliette
authors.initials: J
authors.lastname: Sailland
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Vanacker
mesh_terms: D000818:Animals; D002465:Cell Movement; D049109:Cell Proliferation; D004734:Energy Metabolism; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011960:Receptors, Estrogen / Q000378:metabolism*; D020218:Response Elements
chemical_list: D011960:Receptors, Estrogen