title: [Whipple's disease: a curable encephalitis].
abstract: BACKGROUND
  Whipple's disease is a rare systemic infectious disorder. It may present with a wide range of clinical manifestations and therefore its diagnosis may be challenging.
  
  
  METHODS
  We report a 45-year-old man who presented with acute encephalitis related to Whipple's disease. Despite the negativity of the polymerase chain reaction (PCR) test in cerebrospinal fluid, diagnosis was obtained by histopathology, PCR tests and immunohistochemistry in multiple samples. The outcome with antibiotherapy was considered as "spectacular".
  
  
  CONCLUSIONS
  Whipple's disease is a rare cause of encephalitis. Its diagnosis needs the confrontation of histology and PCR tests in multiple samples. The outcome with an adapted antibiotherapy may be very successful.
authors.affiliation: Clinique de médecine interne, CHU, BP 217, 38043 Grenoble cedex 09, France. CWintenberger@chu-grenoble.fr
authors.forename: C
authors.initials: C
authors.lastname: Wintenberger
authors.forename: A
authors.initials: A
authors.lastname: Bosseray
authors.forename: B
authors.initials: B
authors.lastname: Colombe
authors.forename: B
authors.initials: B
authors.lastname: Gestin
authors.forename: S
authors.initials: S
authors.lastname: Grand
authors.forename: C
authors.initials: C
authors.lastname: Massot
mesh_terms: D004660:Encephalitis / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D008061:Whipple Disease / Q000188:drug therapy*