title: A prospective double blind trial investigating impact of vaginal pH on efficacy of prostaglandin gel for cervical ripening and course of labour.
abstract: This prospective, double blind investigation was carried out to see the effect of vaginal pH on the efficacy of prostaglandin gel (PGE2) for cervical ripening and course of labour. A total of 45 pregnant women with indications for induction of labour were allocated to two groups: a low vaginal pH (≤5.5, n = 20) and high vaginal pH (>5.5, n = 25) group. All women received prostaglandin E2 gel (0.5 mg in 2.5 ml) intravaginally with repeated dosing if needed, 6 h apart, maximum of three doses. Bishop's score change over 18 h differed significantly between the two groups (p = 0.037). There was no significant difference between the groups with respect to time to onset of labour (9.65±6.29 vs 6.76±3.94, p = 0.066), time to active labour (15.38±9.49 vs 14.30±5.85, p = 0.664), time to complete cervical dilation (18.27±13.85 vs 18.34±6.45; p = 0.984), and time to overall delivery (21.52±9.66 vs 19.39±6.45, p = 0.381).
authors.affiliation: Department of Obstetrics and Gynaecology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India.
authors.forename: U
authors.initials: U
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Mehrotra
authors.forename: H P
authors.initials: HP
authors.lastname: Gupta
authors.forename: A
authors.initials: A
authors.lastname: Dhakad
authors.forename: V
authors.initials: V
authors.lastname: Jain
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D020070:Cervical Ripening / Q000187:drug effects*; D015232:Dinoprostone / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007751:Labor, Induced / Q000379:methods*; D007743:Labor, Obstetric / Q000187:drug effects*; D010120:Oxytocics / Q000008:administration & dosage*; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors; D014621:Vagina / Q000737:chemistry*
chemical_list: D005782:Gels; D010120:Oxytocics; D015232:Dinoprostone