title: Association of HLA-DRB1*15 allele and CSF oligoclonal bands in a Spanish multiple sclerosis cohort.
abstract: OBJECTIVE
  The HLA-DRB1*15 allele is consistently associated with multiple sclerosis (MS) susceptibility in most studied populations. This study investigated the association between HLA-DRB1 alleles and the presence of oligoclonal immunoglobulin G bands (OCB) in the cerebrospinal fluid (CSF) in a Spanish population with MS.
  
  
  METHODS
  The HLA-DRB1 typing was performed in 268 patients with sporadic MS and the detection of OCB in CSF. HLA-DRB1 allelic frequencies were compared between OCB-positive and OCB-negative patients, and both groups were also compared with 1088 unrelated healthy controls. Moreover, we correlated the various HLA-DRB1 genotypes, considering all the combinations of both parental alleles found with the presence or absence of OCB.
  
  
  RESULTS
  We found 206 OCB-positive and 62 OCB-negative patients. The HLA-DRB1*15 allele in OCB-positive patients had a higher frequency when compared with OCB-negative patients (39.3% in OCB-positive vs. 16.1% in OCB-negative, OR = 1.38 95% CI = 1.18-1.61, P < 0.001). The other alleles did not show differences. When we compared with controls, the HLA-DRB1*15 allele was associated with the disease only in the OCB-positive patients group. None of the 55 genotypes found showed any association with the presence or absence of OCB.
  
  
  CONCLUSIONS
  HLA-DRB1*15 allele is associated with OCB-positive patients with MS when studying a Spanish MS population.
authors.affiliation: Multiple Sclerosis Unit, Neurology Department, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Romero-Pinel
authors.forename: S
authors.initials: S
authors.lastname: Martínez-Yélamos
authors.forename: L
authors.initials: L
authors.lastname: Bau
authors.forename: E
authors.initials: E
authors.lastname: Matas
authors.forename: L
authors.initials: L
authors.lastname: Gubieras
authors.forename: J
authors.initials: J
authors.lastname: María Pujal
authors.forename: F
authors.initials: F
authors.lastname: Morandeira
authors.forename: J
authors.initials: J
authors.lastname: Bas
authors.forename: T
authors.initials: T
authors.lastname: Arbizu
mesh_terms: D000328:Adult; D000483:Alleles; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid / Q000235:genetics; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology; D015995:Prevalence; D013030:Spain / Q000453:epidemiology
chemical_list: D059811:HLA-DRB1 Chains; C507799:HLA-DRB1*15 antigen; D007074:Immunoglobulin G; D043025:Oligoclonal Bands