title: Blood cell microRNAs: what are they and what future do they hold?
abstract: The advent of blood component storage revolutionized health care by allowing for a managed supply of transfusion quality blood products. During storage, blood components undergo a series of physiological changes that affect the product quality, which ultimately can interfere with the safety and efficacy of such products after transfusion. Despite continuous improvements in blood component quality and safety, it is still desirable to have in vitro standard markers of measurable characteristics that predict blood component safety and efficacy in vivo following their transfusion. Over the last decade, research on the feasibility of using microRNAs as biomarkers for various clinical manifestations and cellular pathologies has exploded. Here, we review the literature on blood cell microRNAs and discuss the potential of these molecules to act as measurable characteristics (product biomarkers) for stored blood component quality and safety.
authors.affiliation: Section of Cell Biology, Laboratory of Cellular Hematology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ryan
authors.forename: Chintamani
authors.initials: C
authors.lastname: Atreya
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000378:metabolism; D001773:Blood Cells / Q000378:metabolism*; D016913:Blood Component Transfusion; D001793:Blood Preservation / Q000379:methods; D058731:Blood Safety / Q000379:methods; D001803:Blood Transfusion / Q000379:methods / Q000639:trends*; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000097:blood* / Q000502:physiology*; D008954:Models, Biological; D011786:Quality Control
chemical_list: D015415:Biomarkers; D035683:MicroRNAs