title: [Gliomatosis cerebri with multifocal progressive lesions on MRI].
abstract: A 77-year-old woman with cognitive impairment and multifocal progressive lesions on brain MRI was admitted to our hospital. Analysis of blood and cerebrospinal fluid showed no evidence of infection, autoimmune disease, or metabolic abnormalities. Histological examination of biopsied tissue from a lesion in the right frontal lobe revealed an abnormally increased glial cell density with enlarged nuclei and a high MIB-1 index. These pathological findings coupled with her progressive clinical history indicated a diagnosis of gliomatosis cerebri. General characteristics of gliomatosis cerebri include diffuse infiltrative lesions in neuroimaging with or without mass effect. However, the present case showed unusual multifocal manifestations in brain MRI. Therefore, histopathological examination must be taken into account for a proper diagnosis.
authors.affiliation: Department of Neurology, Hokkaido University Graduate School of Medicine.
authors.forename: Ken
authors.initials: K
authors.lastname: Sakushima
authors.forename: Moemi
authors.initials: M
authors.lastname: Yashima-Yamada
authors.forename: Kanako
authors.initials: K
authors.lastname: Kubota
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sawamura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yabe
authors.forename: Hidenao
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018302:Neoplasms, Neuroepithelial / Q000473:pathology*