title: Absence of BRAF and HRAS mutations in eruptive Spitz naevi.
abstract: BACKGROUND
  Eruptive Spitz naevi have been reported rarely in the literature. In solitary Spitz naevi, BRAF and HRAS mutations, as well as increased copy numbers of chromosome 11p have been identified.
  
  
  OBJECTIVE
  To investigate the genetic changes underlying eruptive Spitz naevi.
  
  
  METHODS
  We report on a 16-year-old boy who developed multiple disseminated eruptive Spitz naevi within a few months. We analysed BRAF, HRAS, KRAS and NRAS genes in 39 naevi from this patient for hotspot mutations. Furthermore, comparative genomic hybridization analysis was performed in three lesions.
  
  
  RESULTS
  None of the Spitz naevi displayed a mutation in the analysed genes, and no chromosomal imbalances were observed. Conclusions  Our results indicate that the typical genetic alterations described in solitary Spitz naevi appear to be absent in eruptive Spitz naevi. Yet unknown alternative genetic alterations must account for this rare syndrome.
authors.affiliation: Department of Dermatology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Gantner
authors.forename: T
authors.initials: T
authors.lastname: Wiesner
authors.forename: L
authors.initials: L
authors.lastname: Cerroni
authors.forename: I
authors.initials: I
authors.lastname: Lurkin
authors.forename: E C
authors.initials: EC
authors.lastname: Zwarthoff
authors.forename: M
authors.initials: M
authors.lastname: Landthaler
authors.forename: C
authors.initials: C
authors.lastname: Hafner
mesh_terms: D000293:Adolescent; D004252:DNA Mutational Analysis; D011905:Genes, ras; D006801:Humans; D008297:Male; D009154:Mutation; D018332:Nevus, Epithelioid and Spindle Cell / Q000235:genetics* / Q000473:pathology; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*
chemical_list: D048493:Proto-Oncogene Proteins B-raf; D016283:Proto-Oncogene Proteins p21(ras)