title: [Is haemostasis assessment mandatory in case of pregnancy loss?].
abstract: Pregnancy losses must be categorised into biochemical loss, early embryonic loss, late foetal loss and stillbirth cases. No haemostasis-related investigations are necessary for biochemical losses. Antiphospholipid antibodies must be checked for three early losses or one late loss. A complete blood count will reveal the rare essential thrombocytemias, a functional fibrinogen assay the exceptional dysfibrinogenemia cases. Vitamin B12 and intracellular folates levels must be checked in case of clinical or biological suspicion. Constitutive thrombophilias must not be routinely assessed because a therapeutic option is not definitively demonstrated. Screening for constitutive thrombophilias should be only indicated for clinical research purposes, only for late foetal loss and stillbirth cases.
authors.affiliation: Laboratoire et Consultations d'Hématologie, Centre Hospitalier Universitaire, Groupe Hospitalo-Universitaire Caremeau, Nîmes, France. jean.christophe.gris@chu-nimes.fr
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Gris
authors.forename: Eva
authors.initials: E
authors.lastname: Cochery-Nouvellon
authors.forename: Eric
authors.initials: E
authors.lastname: Mercier
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood* / Q000209:etiology; D017152:Antibodies, Antiphospholipid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count; D005260:Female; D005492:Folic Acid / Q000097:blood; D006487:Hemostasis; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications; D014805:Vitamin B 12 / Q000097:blood; D014803:Vitamin B Complex / Q000097:blood
chemical_list: D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D014803:Vitamin B Complex; D005492:Folic Acid; D014805:Vitamin B 12