title: Therapeutic hotline. Does isotretinoin have effect on vitamin D physiology and bone metabolism in acne patients?
abstract: Isotretinoin is an effective therapy for severe nodulocystic acne. Several experimental studies suggest that it may have an effect on vitamin D physiology. In the present study, the authors aimed to investigate the effect of isotretinoin treatment on the metabolism of vitamin D in acne patients. A prospective analysis of 50 consecutive acne patients who were treated with isotretinoin for 3 months was done. Before and after 3 months of treatment, 25 hydroxy vitamin D, 1,25 dihydroxy vitamin D, and bone alkaline phosphatase, calcium, phosphate, and parathormone levels were measured. The 25 hydroxy vitamin D and serum calcium levels decreased significantly (p < 0.0001, p < 0.05, respectively), whereas 1,25 dihydroxy vitamin D, parathormone, and bone alkaline phosphatase levels increased significantly after 3 months of isotretinoin treatment (p < 0.005, p < 0.005, p < 0.0001, respectively). Aspartate aminotransferase, total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels also increased significantly after isotretinoin treatment. This prospective clinical study showed that isotretinoin has an effect on vitamin D metabolism. Further clinical studies with longer periods of follow-up are needed to understand the effect of isotretinoin on vitamin D and bone metabolism.
authors.affiliation: Department of Internal Medicine, Ankara Kecioren Research and Training Hospital, Ankara, Turkey. dertaner@gmail.com
authors.forename: Derun Taner
authors.initials: DT
authors.lastname: Ertugrul
authors.forename: Ayse Serap
authors.initials: AS
authors.lastname: Karadag
authors.forename: Emre
authors.initials: E
authors.lastname: Tutal
authors.forename: Kadir Okhan
authors.initials: KO
authors.lastname: Akin
mesh_terms: D000152:Acne Vulgaris / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000097:blood; D003879:Dermatologic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D008055:Lipids / Q000097:blood; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003879:Dermatologic Agents; D008055:Lipids; C470125:PTH protein, human; D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; C104450:25-hydroxyvitamin D; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D015474:Isotretinoin; D002118:Calcium