title: Mid-term prognosis after endoscopic resection for submucosal colorectal carcinoma: summary of a multicenter questionnaire survey conducted by the colorectal endoscopic resection standardization implementation working group in Japanese Society for Cancer of the Colon and Rectum.
abstract: We carried out a retrospective questionnaire survey of 792 submucosal colorectal carcinoma (CRC) cases from 15 institutions affiliated with the Colorectal Endoscopic Resection Standardization Implementation Working Group in Japanese Society for Cancer of the Colon and Rectum. In these cases, endoscopic resection (ER) and surveillance was carried out without additional surgical resection. Local recurrence or metastasis was observed in 18 cases. Local submucosal recurrence was observed in 11 cases, and metastatic recurrence was observed in 13 cases. Among the 15 cases in which the depth of submucosal invasion was measured, two cases showed depth less than 1000 µm, which has other risk factors for metastasis. Metastatic recurrence was observed in the lung, liver, lymph node, bone, adrenal glands, and the brain; in some cases, metastatic recurrence was observed in multiple organs. Death due to primary disease was observed in six cases. The average interval between ER and recurrence was 19.7 ± 9.2 months. In 16 cases, recurrence was observed within 3 years after ER. Thus, validity of ER without additional surgical resection for cases with the conditions that the depth of submucosal invasion is less than 1000 µm and the histological grade is well or moderately differentiated adenocarcinoma with no lymphatic and venous involvement was proven.
authors.affiliation: Colorectal Endoscopic Resection Standardization Implementation Working Group in Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Oka
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kanao
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Igarashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saito
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ikematsu
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Inoue
authors.forename: Naohisa
authors.initials: N
authors.lastname: Yahagi
authors.forename: Sumio
authors.initials: S
authors.lastname: Tsuda
authors.forename: Seiji
authors.initials: S
authors.lastname: Simizu
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iishi
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yamano
authors.forename: Shin-ei
authors.initials: SE
authors.lastname: Kudo
authors.forename: Osamu
authors.initials: O
authors.lastname: Tsuruta
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tamura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Saito
authors.forename: Eisai
authors.initials: E
authors.lastname: Cho
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujii
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sano
authors.forename: Hisashi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
authors.forename: Tetsuichiro
authors.initials: T
authors.lastname: Muto
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology / Q000601:surgery*; D007564:Japan; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000401:mortality; D011159:Population Surveillance; D011183:Postoperative Complications / Q000175:diagnosis / Q000401:mortality; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012307:Risk Factors; D012955:Societies, Medical; D011795:Surveys and Questionnaires; D016019:Survival Analysis