title: [Histopathologic analysis of 1500 renal allograft biopsies].
abstract: OBJECTIVE
  To summarize the histopathological features of posttransplant complications for renal allografts and evaluate the biopsy values.
  
  
  METHODS
  Between January 1997 and May 2010, a total of 1712 percutaneous renal allograft biopsies were performed in 1500 kidney transplants and diagnostic procedures for staining, classification and staging had been performed according to the Banff 1997 and 2005 Schema.
  
  
  RESULTS
  There were 213 (14.2%) cases of acute T cell-mediated rejection post transplantation in 1500 kidney transplants. Meanwhile there were 36 (2.4%) cases of acute antibody-mediated rejection. Chronic T cell-mediated rejection and chronic antibody-mediated rejection were 251 (16.7%) cases and 45 (3.0%) cases, respectively. Acute CNI-nephrotoxicity and chronic CNI-nephrotoxicity were 106 (7.1%)cases and 251 (16.7%) cases, respectively. Relapsed or new nephropathy were 6 (0.4%) cases. Chronic CNI-nephrotoxicity is the most common cause of allograft dysfunction in the long survival recipients.
  
  
  CONCLUSIONS
  Percutaneous renal allograft biopsy is valuable for the diagnosis of various posttransplantation complications.
authors.affiliation: Institute of Organ Transplantation, Key Lab on Transplantation of Ministry of Education and Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.forename: Zheng-bin
authors.initials: ZB
authors.lastname: Lin
authors.forename: Wei-jie
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Chang-sheng
authors.initials: CS
authors.lastname: Ming
authors.forename: Zhi-shui
authors.initials: ZS
authors.lastname: Chen
authors.forename: Fan-jun
authors.initials: FJ
authors.lastname: Zeng
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Ji-pin
authors.initials: JP
authors.lastname: Jiang
authors.forename: Nian-qiao
authors.initials: NQ
authors.lastname: Gong
authors.forename: Lai
authors.initials: L
authors.lastname: Wei
authors.forename: Hui-bo
authors.initials: HB
authors.lastname: Shi
authors.forename: Dun-feng
authors.initials: DF
authors.lastname: DU
authors.forename: Zhong-hua
authors.initials: ZH
authors.lastname: Chen
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D006084:Graft Rejection / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D016030:Kidney Transplantation / Q000473:pathology*; D008875:Middle Aged; D019737:Transplants; D055815:Young Adult