title: C1q nephropathy presenting as acute renal failure.
abstract: We describe a 42-year-old male patient who presented with high grade fever associated with acute renal failure requiring hemodialysis. Renal biopsy revealed that he had focal proliferative glomerulonephritis on light microscopy, dominant mesangial deposition of C1q by immunofluorescent staining, and electron dense deposits on electron microscopy, with no evidence of systemic lupus erythematosus, compatible with the diagnosis of C1q nephropathy. Intensive treatment with a combination of methyl prednisolone pulse therapy and oral prednisolone was successful in achieving complete remission and disappearance of proteinuria in our patient.
authors.affiliation: Department of Nephrology, Lilavati Hospital and Research Centre, Mumbai, India. dr_pavanm@yahoo.co.in
authors.forename: Pavan
authors.initials: P
authors.lastname: Malleshappa
authors.forename: Ravi
authors.initials: R
authors.lastname: Ranganath
authors.forename: Anup P
authors.initials: AP
authors.lastname: Chaudhari
authors.forename: Ashwinikumar
authors.initials: A
authors.lastname: Ayiangar
authors.forename: Suratkal
authors.initials: S
authors.lastname: Lohitaksha
mesh_terms: D058186:Acute Kidney Injury / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D000284:Administration, Oral; D000328:Adult; D001706:Biopsy; D015922:Complement C1q / Q000276:immunology*; D004359:Drug Therapy, Combination; D005334:Fever / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007668:Kidney / Q000276:immunology* / Q000648:ultrastructure; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008854:Microscopy, Electron; D011239:Prednisolone / Q000008:administration & dosage; D011507:Proteinuria / Q000276:immunology; D020551:Pulse Therapy, Drug; D006435:Renal Dialysis; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D015922:Complement C1q; D011239:Prednisolone; D008775:Methylprednisolone