title: Evaluation of Aβ fibrillization inhibitory effect by a PEG-peptide conjugate based on an Aβ peptide fragment with intramolecular FRET.
abstract: A PEG-peptide conjugate based on an amyloid β peptide fragment was synthesized. The formed amyloid protofibril-like aggregates induced intramolecular FRET. It proved to be useful as a bioprobe to evaluate the inhibitory effect of organic molecules toward amyloid fibrillization.
authors.affiliation: Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-chou, Tottori 680-8552, Japan. sakurai@bio.tottori-u.ac.jp
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Sakurai
authors.forename: Tomoki
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Okuno
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kawata
authors.forename: Naoki
authors.initials: N
authors.lastname: Kise
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D015394:Molecular Structure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D011092:Polyethylene Glycols