title: A case of idiopathic systemic capillary leak syndrome with high serum levels of G-CSF on exacerbation.
abstract: Systemic capillary leak syndrome (SCLS) is a life-threatening disorder which presents with periodic episodes of hypovolemic shock, due to plasma leakage to the extra-vascular space reflected by accompanying hypoalbuminemia, hemoconcentration and edema often with associated monoclonal gammopathy. We describe a 28-year-old woman with SCLS who required aggressive fluid resuscitation and was successfully treated with corticosteroid, terbutaline, and theophylline. At exacerbation, the levels of serum granulocyte colony-stimulating factor (G-CSF) were increased. Thus, G-CSF might play an important role and can be a useful biomarker for the severity of attacks in SCLS.
authors.affiliation: Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University, Japan. naka-nao@asahikawa-med.ac.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakagawa
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Ota
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Maki
authors.initials: M
authors.lastname: Kabara
authors.forename: Motoki
authors.initials: M
authors.lastname: Matsuki
authors.forename: Junko
authors.initials: J
authors.lastname: Chinda
authors.forename: Naka
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Fujino
authors.forename: Naofumi
authors.initials: N
authors.lastname: Takehara
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kawabe
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuhara
authors.forename: Katsuya
authors.initials: K
authors.lastname: Ikuta
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hasebe
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D019559:Capillary Leak Syndrome / Q000097:blood* / Q000175:diagnosis*; D018450:Disease Progression; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans
chemical_list: D015415:Biomarkers; D016179:Granulocyte Colony-Stimulating Factor