title: Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults.
abstract: BACKGROUND
  High viscosity fibre is known to exert many beneficial effects on appetite and metabolism. It could potentially help in weight management, in dieting or nondieting individuals. The present study investigated the effects of the daily intake of a novel high viscosity polysaccharide (HVP) over 3 months in nondieting obese or overweight men and women.
  
  
  METHODS
  The study comprised a double-blind, randomised controlled clinical trial. Participants ingested 5-15 g per day of either HVP (n = 29, experimental group) or inulin (n = 30, control group) for 15 weeks. Changes in anthropometry (weight, waist and hip circumferences), blood lipids and glucose tolerance were studied from the beginning to the end of administration. Compliance and tolerance were examined.
  
  
  RESULTS
  Differences appeared between HVP and inulin supplementation in female participants only. Mean (SD) decreases in body weight [1.6 (3.2) kg; approximately 2% of initial weight] and hip circumference [2.8 (3.6 ) cm] occurred in women of the HVP group but not in controls (Time × Group interactions, P ≤ 0.002). Total, high-density lipoprotein and low-density lipoprotein-cholesterol were lower at the end of supplementation in the women of the HVP group compared to controls (P ≤ 0.021). No effect appeared in waist circumference and triacylglycerol. No difference was noted in the number or severity of the adverse effects reported in both groups. Adverse effects were mild and agreed with commonly reported reactions to intake of dietary fibre.
  
  
  CONCLUSIONS
  Beneficial although modest effects appeared after several weeks of daily HVP intake in nondieting obese or overweight women. The effects of HVP should be investigated in the context of a weight loss programme.
authors.affiliation: Canadian Centre for Functional Medicine, Coquitlam, BC.
authors.forename: M
authors.initials: M
authors.lastname: Lyon
authors.forename: S
authors.initials: S
authors.lastname: Wood
authors.forename: X
authors.initials: X
authors.lastname: Pelletier
authors.forename: Y
authors.initials: Y
authors.lastname: Donazzolo
authors.forename: R
authors.initials: R
authors.lastname: Gahler
authors.forename: F
authors.initials: F
authors.lastname: Bellisle
mesh_terms: D000328:Adult; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D004038:Diet, Reducing; D004040:Dietary Carbohydrates / Q000494:pharmacology / Q000627:therapeutic use; D004043:Dietary Fiber / Q000494:pharmacology / Q000627:therapeutic use*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006615:Hip / Q000033:anatomy & histology; D006801:Humans; D007444:Inulin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy*; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D012737:Sex Factors; D014783:Viscosity; D055105:Waist Circumference; D015431:Weight Loss; D055815:Young Adult
chemical_list: D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D011134:Polysaccharides; D007444:Inulin; D002784:Cholesterol