title: Relationship between primary nodal generalized osteoarthritis with tissue antigens HLA-A and HLA-B in the western Black Sea region of Turkey.
abstract: OBJECTIVE
  To investigate the relationship between patients diagnosed with nodal generalized osteoarthritis (NGOA) and tissue antigens HLA-A and HLA-B in the Western Black Sea Region of Turkey.
  
  
  METHODS
  Forty-six patients with NGOA (64.74±8.46) and 60 controls (62.32±6.8) were included in the study. Inclusion criteria were: (i) stage 2 and higher OA of the hand and knee based on the Kellgren-Lawrence classification, and (ii) stage 2 and higher lumbar disc degeneration according to Lawrence classification. Family histories were taken from patients. HLA-A and HLA-B were typed by PCR using sequence specific primer.
  
  
  RESULTS
  The frequencies of HLA-A(*)02 and HLA-B(*)38 were 58.7% and 15.2%, respectively, in patients with NGOA, and there was a statistically significant relationship between the disease and HLA-A(*)02 and HLA-B(*)38. The relationship between positive family history and HLA-B(*)44 allele was also statistically significant. In the control group, the frequency of HLA-A(*)29 was 11.7% and it was statistically significant.
  
  
  CONCLUSIONS
  To our knowledge this is the first study to demonstrate the epidemiologic association between HLA-A(*)02 and HLA-B(*)38 with NGOA in our population. We conclude that, HLA-B(*)44 positivity may be associated with familial NGOA and HLA-A(*)29 may be a preventive factor against NGOA.
authors.affiliation: Department of Physican Medicine and Rehabilitation, Abant Izzet Baysal University, Izzet Baysal Medical School, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Tasligil
authors.forename: Sirzat
authors.initials: S
authors.lastname: Cogalgil
authors.forename: Esra
authors.initials: E
authors.lastname: Tug
authors.forename: Burak
authors.initials: B
authors.lastname: Tonuk
authors.forename: Ozlem
authors.initials: O
authors.lastname: Sahin
authors.forename: Dilek
authors.initials: D
authors.lastname: Dogruer
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D059038:Black Sea / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000097:blood*; D015789:HLA-A2 Antigen / Q000097:blood; D015235:HLA-B Antigens / Q000097:blood*; D059945:HLA-B38 Antigen / Q000097:blood; D059948:HLA-B44 Antigen / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D015234:HLA-A Antigens; C524866:HLA-A*02 antigen; D015789:HLA-A2 Antigen; C035524:HLA-A29 antigen; D015235:HLA-B Antigens; D059945:HLA-B38 Antigen; D059948:HLA-B44 Antigen