title: Expression of Toll-like receptor 4 and beta 1 integrin in breast cancer.
abstract: Toll-like receptor (TLR) 4 signaling pathway has been shown to support tumor cell growth in vitro and in vivo. Its stimulation on breast cancer cell lines induces β1 integrin and promotes tumor invasiveness. However, its role in predicting clinical behavior of tumor is not yet clarified. Therefore, we investigated TLR4 and β1 integrin expression on 133 primary breast cancer samples by immunohistochemistry and correlated it with overall survival and disease-free survival of patients as well as with clinicopathological characteristics of the tumor. We found higher β1 integrin expression in invasive lobular cancer in comparison with other tumor types. No significant association of TLR4 and β1 integrin expression with overall survival or disease-free survival was seen. Therefore, we conclude that expression of these markers is of biological interest but appears to be of little additional use as predictive clinical marker.
authors.affiliation: Department of Pathophysiology, Zagreb University Medical School, 10000 Zagreb, Croatia. bpetricevic2001@yahoo.com
authors.forename: B
authors.initials: B
authors.lastname: Petricevic
authors.forename: D
authors.initials: D
authors.lastname: Vrbanec
authors.forename: J
authors.initials: J
authors.lastname: Jakic-Razumovic
authors.forename: I
authors.initials: I
authors.lastname: Brcic
authors.forename: D
authors.initials: D
authors.lastname: Rabic
authors.forename: T
authors.initials: T
authors.lastname: Badovinac
authors.forename: E
authors.initials: E
authors.lastname: Ozimec
authors.forename: V
authors.initials: V
authors.lastname: Bali
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D019012:Integrin beta1 / Q000378:metabolism*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
chemical_list: D019012:Integrin beta1; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4