title: [CRISPR-Cas system and coevolution of bacteria and phages].
abstract: In response to the challenge from phages, bacteria evolve a number of defense systems against phage invasion. Meanwhile, the phages evolve multiple counter-defense mechanism as well under the selection pressure from bacteria. The evolution relationship between bacteria and phages, as well as the functional mechanism, still remains to be uncovered. A novel immune system, CRISPR-Cas system, has been found in bacteria and archaea recently. With deeply research of the function and mechanism of CRISPR-Cas system, the coevolution relationship between bacteria and phages is becoming clear. In this review, the mechanism of CRISPR-Cas system-mediated immunity in prokaryotes is introduced. In particular, the progress on the role of CRISPR in the coevolution of bacteria and phage is reviewed.
authors.affiliation: College of Life Science, Liaoning University, Shenyang 110036, China. tieminli@lnu.edu.cn
authors.forename: Tie-Min
authors.initials: TM
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Du
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics*; D018407:Bacterial Physiological Phenomena / Q000235:genetics; D001435:Bacteriophages / Q000235:genetics* / Q000502:physiology; D019143:Evolution, Molecular; D018895:Microsatellite Repeats / Q000235:genetics*; D009154:Mutation