title: Prevalence of faecal ESBL carriage in the community and in a hospital setting in a county of Southern Sweden.
abstract: The aim of this study was to investigate the prevalence of extended-spectrum beta-lactamase (ESBL)-producing bacteria in patients at various hospital wards and in a group of relatively healthy volunteers, in order to obtain greater knowledge on how common these bacterial strains are in hospital settings and in the general community. Participants (n = 427) were enrolled at a University Hospital and at Primary Health Care Units (PHCUs) in Sweden in 2008 and 2010. The participants provided rectal swabs, which were tested for the occurrence of ESBL-producing bacteria. Positive samples were analysed with polymerase chain reaction (PCR) methods for bacterial strain typing and ESBL phylogroups. In 2008, the prevalence was 2.1% (2/96) in PHCU subjects and 1.8% (2/113) in hospital patients. In 2010, the prevalence was 3.0% (3/100) in PHCU subjects and 6.8% (8/118) in hospital patients. The dominating phylogroups were CTX-M-1 and CTX-M-9. All ESBL-positive isolates were Escherichia coli. We found a higher prevalence of ESBL faecal carriage than expected, both in the hospital setting and in the PHCU group.
authors.affiliation: Infectious Diseases Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Strömdahl
authors.forename: J
authors.initials: J
authors.lastname: Tham
authors.forename: E
authors.initials: E
authors.lastname: Melander
authors.forename: M
authors.initials: M
authors.lastname: Walder
authors.forename: P J
authors.initials: PJ
authors.lastname: Edquist
authors.forename: I
authors.initials: I
authors.lastname: Odenholt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004926:Escherichia coli / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology*; D005260:Female; D005838:Genotype; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D015995:Prevalence; D013548:Sweden; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases