title: Phase II study of FOLFOX4 with "wait and go" strategy as first-line treatment for metastatic colorectal cancer.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of FOLFOX4 using "wait and go" strategy in treating metastatic colorectal cancer.
  
  
  METHODS
  The conventional FOLFOX4 was repeated every 2 weeks. We waited until the recovery of symptoms from persistent neurotoxicity within an added period of 2 weeks, before performing the next cycle ("wait and go" strategy).
  
  
  RESULTS
  We enrolled 58 patients, in whom a total of 481 cycles were administered (median 8 per patient; range 1-16). Toxicity was evaluated in 58 patients and response in 55. The major toxic effect was grade 3/4 neutropenia (33%). Painful paresthesia or persistent functional impairment was observed in 4 patients (7%). The response rate was 40% (95% confidence interval; 27.1-52.9%). The median progression-free survival time was 10.2 months, the 1-year survival rate was 89%, and the median overall survival time was 27.6 months.
  
  
  CONCLUSIONS
  These findings indicate that this "wait and go" strategy reduces the frequency of persistent neuropathy while maintaining efficacy against metastatic colorectal cancer.
authors.affiliation: Department of Digestive Surgery, Nihon University School of Medicine, 30-1, Oyaguchikami-machi, Itabashi-ku, Tokyo 173-8610, Japan.
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Kochi
authors.forename: Wataru
authors.initials: W
authors.lastname: Ichikawa
authors.forename: Eiji
authors.initials: E
authors.lastname: Meguro
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shibata
authors.forename: Takuji
authors.initials: T
authors.lastname: Fukui
authors.forename: Michitaka
authors.initials: M
authors.lastname: Nagase
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Masashi
authors.initials: M
authors.lastname: Fujii
authors.forename: Toshifusa
authors.initials: T
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009944:Organoplatinum Compounds / Q000008:administration & dosage
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil