title: Prospective evaluation of hemostatic abnormalities in overt DIC due to various underlying diseases.
abstract: Patients with suspected disseminated intravascular coagulation (DIC) were prospectively evaluated for various types of underlying diseases, and the usefulness of hemostatic markers were examined for each patient with DIC due to various underlying diseases. The main underlying disease of DIC was infectious diseases, hematologic malignancies, and solid tumors, and a high resolution rate from DIC was observed in obstetric diseases and hematologic malignancies. The diagnosis of DIC was related to a poor outcome in trauma/burn victims and those with infectious disease. In the main underlying disease, it is suggested that DIC would be excluded in patients with hematologic malignancies or solid tumors with a platelet count of more than 100,000/μl and in the patients with an FDP of less than 10 μg/ml, and fibrinogen of less than 100mg/dl, suggesting the presence of DIC. The prothrombin time was a sensitive marker, but fibrinogen levels were not sensitive for DIC due to infectious diseases. The plasmin plasmin inhibitor complex in hematologic malignancy, and soluble fibrin monomer complex, antithrombin and thrombomodulin in patients with infectious disease, were sensitive markers for the diagnosis of DIC. Although hemostatic markers were useful for the diagnosis of DIC, the usefulness varied depending on the different underlying diseases.
authors.affiliation: Department of Internal Medicine, Teikyo University School of Medicine, Itabashi.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kawasugi
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hatada
authors.forename: Kohji
authors.initials: K
authors.lastname: Okamoto
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kushimoto
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Seki
authors.forename: Takashi
authors.initials: T
authors.lastname: Okamura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nobori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000150:complications*; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies