title: [Mitochondrial calcium channels - a new pharmacological target?].
abstract: Calcium is of vital importance to cardiac cell function and plays an important role in heart failure. The mechanism of calcium regulation by mitochondria is still not fully resolved. This review is focused on the function, regulation, and possible therapeutic potential of cardiac mitochondrial Ca(2+) channels.
authors.affiliation: Klinik III für Innere Medizin, Universität zu Köln, Germany. guido.michels@uk-koeln.de
authors.forename: G
authors.initials: G
authors.lastname: Michels
authors.forename: E
authors.initials: E
authors.lastname: Erdmann
authors.forename: U C
authors.initials: UC
authors.lastname: Hoppe
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects*; D003600:Cytosol / Q000187:drug effects / Q000502:physiology; D015195:Drug Design; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology*; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D009206:Myocardium / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000502:physiology; D012428:Ruthenium / Q000494:pharmacology; D015290:Second Messenger Systems / Q000187:drug effects / Q000502:physiology
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D012428:Ruthenium; D002118:Calcium