title: Blood banking in living droplets.
abstract: Blood banking has a broad public health impact influencing millions of lives daily. It could potentially benefit from emerging biopreservation technologies. However, although vitrification has shown advantages over traditional cryopreservation techniques, it has not been incorporated into transfusion medicine mainly due to throughput challenges. Here, we present a scalable method that can vitrify red blood cells in microdroplets. This approach enables the vitrification of large volumes of blood in a short amount of time, and makes it a viable and scalable biotechnology tool for blood cryopreservation.
authors.affiliation: Demirci Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
authors.forename: Josh
authors.initials: J
authors.lastname: Samot
authors.forename: Sangjun
authors.initials: S
authors.lastname: Moon
authors.forename: Lei
authors.initials: L
authors.lastname: Shao
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Youngseok
authors.initials: Y
authors.lastname: Song
authors.forename: Hasan Onur
authors.initials: HO
authors.lastname: Keles
authors.forename: Laura
authors.initials: L
authors.lastname: Matloff
authors.forename: Jordan
authors.initials: J
authors.lastname: Markel
authors.forename: Utkan
authors.initials: U
authors.lastname: Demirci
mesh_terms: D001771:Blood Banks; D015925:Cryopreservation; D005615:Freezing; D006461:Hemolysis; D006801:Humans; D044085:Microfluidics / Q000379:methods*