title: Embryotoxicity and biotransformation responses in zebrafish exposed to water-soluble fraction of crude oil.
abstract: The toxic effects of water-soluble fraction (WSF) of crude oil (API27, Petrobras Campos Basin, Brazil) were evaluated during the early life stages of zebrafish, as well as its biotransformation in juvenile fish. Embryonic development was studied during 96 h. Reduced heartbeat rate, weak pigmentation, tail defects, and embryo mortality were observed for all of the tested concentrations of the WSF. Activities of the biotransformation enzymes were induced at the highest concentrations, showing that these enzymes played a role in its elimination. As shown in this study the crude oil WSF altered the normal embryonic development of fish.
authors.affiliation: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Luciana M
authors.initials: LM
authors.lastname: Pauka
authors.forename: Marcell
authors.initials: M
authors.lastname: Maceno
authors.forename: Stefani C
authors.initials: SC
authors.lastname: Rossi
authors.forename: Helena C
authors.initials: HC
authors.lastname: Silva de Assis
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000196:embryology / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004625:Embryo, Nonmammalian / Q000187:drug effects* / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D010578:Petroleum / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism*
chemical_list: D010578:Petroleum; D014874:Water Pollutants, Chemical; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase