title: Beta 2 toxigenic Clostridium perfringens type A colitis in a three-day-old foal.
abstract: Beta 2 (β2)-toxigenic Clostridium perfringens type A was recovered in large numbers from the intestine of a neonatal foal with colitis. The foal had been treated with gentamicin. Necropsy revealed marked distension of cecum and colon with watery, rust-colored homogeneous fluid and gastric infarction. Microscopic colonic lesions were superficial necrosis of 50% of the colonic mucosal surface and scattered 1-3-mm ulcers with subjacent neutrophilic infiltration and large Gram-positive bacilli in the necrotic mucosa. Beta-2 toxin was demonstrated in the lesions by immunohistochemical staining.
authors.affiliation: Animal Health Laboratory, University of Guelph, Guelph, Ontario, Canada N1G 2W1. mhazlett@uoguelph.ca
authors.forename: Murray J
authors.initials: MJ
authors.lastname: Hazlett
authors.forename: Jasmina
authors.initials: J
authors.lastname: Kircanski
authors.forename: Durda
authors.initials: D
authors.lastname: Slavic
authors.forename: John F
authors.initials: JF
authors.lastname: Prescott
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology*; D003016:Clostridium perfringens / Q000378:metabolism*; D003092:Colitis / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology / Q000662:veterinary*; D004768:Enterotoxins / Q000378:metabolism*; D017809:Fatal Outcome; D005839:Gentamicins / Q000009:adverse effects / Q000494:pharmacology*; D006734:Horse Diseases / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology*; D006736:Horses; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D004768:Enterotoxins; D005839:Gentamicins; C035598:enterotoxin, Clostridium