title: Four new polyoxygenated gorgosterols from the gorgonian Isis hippuris.
abstract: Four new polyoxygenated steroids (1-4) together with four known ones (5-8) have been isolated from the gorgonian Isis hippuris. The structures of the new compounds have been elucidated by spectroscopic analysis and chemical conversion. All of the new steroids showed moderate cytotoxicity against cultured NBT-T2 cells.
authors.affiliation: Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
authors.forename: Mohammad Helal
authors.initials: MH
authors.lastname: Uddin
authors.forename: Novriyandi
authors.initials: N
authors.lastname: Hanif
authors.forename: Agus
authors.initials: A
authors.lastname: Trianto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Agarie
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Higa
authors.forename: Junichi
authors.initials: J
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002460:Cell Line; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D051381:Rats
chemical_list: C021689:gorgosterol; D002784:Cholesterol