title: Toxicological effects of acrylamide on the reproductive system of weaning male rats.
abstract: It has been reported that acrylamide can be detected in starchy food treated by high temperature (120 °C). People could be exposed to acrylamide in factory, laboratory, or even in daily life via diet and drinking water. Recently, the toxicity of acrylamide receives more attention. In addition to the neurotoxicity in humans, other toxic effects of acrylamide are worth further investigation. In this study, we investigated whether acrylamide affected the male reproductive system using high-performance liquid chromatography. In this study, the reproductive toxicity of acrylamide was observed in 3-week-old weaning male Sprague-Dawley rats treated with acrylamide at various doses (0, 5, 15 or 30 mg/kg/day). The results showed that food availability and reproductive organ indexes of the weaning male rats decreased. Levels of follicle-stimulating hormone and testosterone in serum increased while luteinizing hormone in serum decreased. The histopathological lesions and abnormal sperms presented in weaning rats after acrylamide treatment. The results suggested that there is a toxicological effect of acrylamide on the reproductive system of weaning male rats. Based on the findings above, we suggested that more attention should be paid to the toxicological study of acrylamide on weaning male rats or human beings, rather than just on adult male animals.
authors.affiliation: Department of Anatomy and Histology, Basic Medical College, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Ma
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Meige
authors.initials: M
authors.lastname: Zheng
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Sumin
authors.initials: S
authors.lastname: Tian
authors.forename: Xinhong
authors.initials: X
authors.lastname: He
authors.forename: Dexing
authors.initials: D
authors.lastname: Zhang
authors.forename: Guoying
authors.initials: G
authors.lastname: Li
authors.forename: Jiayong
authors.initials: J
authors.lastname: Zhu
mesh_terms: D020106:Acrylamide / Q000633:toxicity*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects* / Q000473:pathology; D005640:Follicle Stimulating Hormone / Q000097:blood; D007150:Immunohistochemistry; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013739:Testosterone / Q000097:blood; D014886:Weaning
chemical_list: D020106:Acrylamide; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone