title: Giant liver hemangioma: the role of female sex hormones and treatment.
abstract: Hepatic hemangiomas are the most common focal liver lesions and are especially prevalent in women. Giant hemangiomas are defined as hemangiomas of at least 4 cm in diameter and the majority remains stable in size over time. However, in some cases hemangiomas display growth and give rise to symptoms because of their space-occupying effect. Causes for the enlargement of the tumors are unknown, but a role of female sex hormones has been suggested. Therefore, hormone therapy should be avoided in patients who became symptomatic. In patients with important symptoms, disease control can be obtained by transcatheter arterial embolization. In selected patients, especially in case of Kasabach-Merritt syndrome, there is a good indication for liver transplantation.
authors.affiliation: Department of Hepatology, University Hospital Gasthuisberg, KU Leuven, Belgium. Hannah.vanmalenstein@uzleuven.be
authors.forename: Hannah
authors.initials: H
authors.lastname: van Malenstein
authors.forename: Geert
authors.initials: G
authors.lastname: Maleux
authors.forename: Diethard
authors.initials: D
authors.lastname: Monbaliu
authors.forename: Chris
authors.initials: C
authors.lastname: Verslype
authors.forename: Mina
authors.initials: M
authors.lastname: Komuta
authors.forename: Tania
authors.initials: T
authors.lastname: Roskams
authors.forename: Wim
authors.initials: W
authors.lastname: Laleman
authors.forename: David
authors.initials: D
authors.lastname: Cassiman
authors.forename: Johan
authors.initials: J
authors.lastname: Fevery
authors.forename: Raymond
authors.initials: R
authors.lastname: Aerts
authors.forename: Jacques
authors.initials: J
authors.lastname: Pirenne
authors.forename: Frederik
authors.initials: F
authors.lastname: Nevens
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D000328:Adult; D004621:Embolization, Therapeutic / Q000379:methods; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006392:Hemangioma, Cavernous / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000601:surgery; D008113:Liver Neoplasms / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011374:Progesterone / Q000009:adverse effects; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D004967:Estrogens; D011374:Progesterone