title: [The drug use results survey of Adenoscan injection 60 mg].
abstract: To investigate the safety and efficacy of Adenoscan injection 60 mg (adenosine), a pharmacologic stress agent that can be used for coronary vasodilation in patients unable to exercise adequately, the drug use results survey was conducted by consecutive patients-survey method in 166 nationwide medical institutes from 2006 to 2008. Adverse drug reactions (ADRs) occurred at the rate of 16.0% (343/2,150 patients), most of which disappeared shortly with no need for treatment. Major ADRs were chest discomfort at the rate of 4.9%, chest pain 2.0%, atrioventricular block 1.8% and dyspnea 1.4%. There were no differences in the incidences of ADRs between the elderly and the non-elderly. The overall efficacy rate was 97.9% (2,104/2,150 patients) according to the efficacy judgment of each primary physician. The sensitivity, specificity and diagnostic accuracy of myocardial perfusion scintigraphy in 608 patients who underwent coronary angiography were 70.8%, 58.1% and 65.0%, respectively. We conclude that adenosine stress is safe and useful for myocardial perfusion scintigraphy to detect ischemic heart disease for patients who are unable to exercise adequately.
authors.affiliation: Pharmacovigilance & Clinical Safety Department, Asubio Pharma Co., Ltd.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hikita
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Okita
authors.forename: Masanori
authors.initials: M
authors.lastname: Kawai
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Suwa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Iizuka
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000009:adverse effects; D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging; D003625:Data Collection; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D055414:Myocardial Perfusion Imaging; D011358:Product Surveillance, Postmarketing; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D000241:Adenosine