title: JC virus variant associated with cerebellar atrophy in a patient with AIDS.
abstract: The human polyomavirus JC virus (JCV) is the agent of progressive multifocal leukoencephalopathy (PML). It has also recently been involved in cerebellar atrophy. Factors involved in this entity are elusive. We present a case of a human immunodeficiency virus (HIV)-infected patient with PML and cerebellar atrophy. In addition to a compartmentalization of JCV strains between urine, cerebrospinal fluid, and cerebellum, specific rearrangements in the JCV regulatory region were observed in the cerebellum, resulting in alterations of transcription factor binding sites. Our data underline the importance of searching for JCV in HIV-infected patients with cerebellar disorders and suggest that mutations in the regulatory region may be involved in cerebellar degeneration.
authors.affiliation: Laboratoire de Microbiologie, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Roux
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Bouldouyre
authors.forename: Séverine
authors.initials: S
authors.lastname: Mercier-Delarue
authors.forename: Danielle
authors.initials: D
authors.lastname: Seilhean
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Zagdanski
authors.forename: Constance
authors.initials: C
authors.lastname: Delaugerre
authors.forename: François
authors.initials: F
authors.lastname: Simon
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Molina
authors.forename: Jerôme
authors.initials: J
authors.lastname: Legoff
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001284:Atrophy / Q000473:pathology*; D002526:Cerebellar Diseases / Q000473:pathology*; D002555:Cerebrospinal Fluid / Q000821:virology; D054022:Cerebrum / Q000473:pathology / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D015321:Gene Rearrangement; D006257:Head / Q000000981:diagnostic imaging; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007577:JC Virus / Q000302:isolation & purification*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D008853:Microscopy; D027601:Polyomavirus Infections / Q000150:complications*; D011859:Radiography; D012045:Regulatory Sequences, Nucleic Acid; D014412:Tumor Virus Infections / Q000150:complications*; D014556:Urine / Q000821:virology
chemical_list: D004279:DNA, Viral