title: [Molecular mechanisms of diabetic wound healing].
abstract: Refractory wound is a severe complication that leads to limb amputation in diabetes, and is also a leading cause of hospitalizations in diabetic patients with limited treatment regimens. However, the underlying mechanisms remain to be fully elucidated. Various factors contribute to delayed diabetic wound healing, such as growth factor, nitric oxide (NO), reactive oxygen species (ROS), matrix metalloproteinases (MMPs), microRNA, endothelial progenitor cells (EPCs), etc. In this review, we will discuss the recent findings on the molecular mechanisms underlying impaired diabetic wound healing.
authors.affiliation: State Key Laboratory of Natural & Biomimetic Drugs and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Tie
authors.forename: Yilixiati
authors.initials: Y
authors.lastname: Xiaokaiti
authors.forename: Xian
authors.initials: X
authors.lastname: Wang
authors.forename: Alex F
authors.initials: AF
authors.lastname: Chen
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Li
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000503:physiopathology*; D017719:Diabetic Foot / Q000503:physiopathology*; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D020782:Matrix Metalloproteinases / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D035683:MicroRNAs; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D020782:Matrix Metalloproteinases