title: Reference systems for the determination of 10B through autoradiography images: application to a melanoma experimental model.
abstract: The amount of (10)B in tissue samples may be determined by measuring the track density in the autoradiography image produced on a nuclear track detector. Different systems were evaluated as reference standards to be used for a quantitative evaluation of boron concentration. The obtained calibration curves were applied to evaluate the concentration of (10)B in melanoma tumour of NIH nude mice after a biodistribution study. The histological features observed in the tissue sections were accurately reproduced by the autoradiography images.
authors.affiliation: Centro Atómico Constituyentes (CAC), Comisión Nacional de Energía Atómica (CNEA), San Martín, Buenos Aires, Argentina. portu@cnea.gov.ar
authors.forename: A
authors.initials: A
authors.lastname: Portu
authors.forename: M
authors.initials: M
authors.lastname: Carpano
authors.forename: A
authors.initials: A
authors.lastname: Dagrosa
authors.forename: S
authors.initials: S
authors.lastname: Nievas
authors.forename: E
authors.initials: E
authors.lastname: Pozzi
authors.forename: S
authors.initials: S
authors.lastname: Thorp
authors.forename: R
authors.initials: R
authors.lastname: Cabrini
authors.forename: S
authors.initials: S
authors.lastname: Liberman
authors.forename: G
authors.initials: G
authors.lastname: Saint Martin
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000379:methods*; D001895:Boron / Q000493:pharmacokinetics*; D002138:Calibration; D004195:Disease Models, Animal; D005260:Female; D008546:Melanoma, Experimental / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D014018:Tissue Distribution
chemical_list: D001895:Boron