title: The effects of leukotriene receptor antagonist montelukast on histological, radiological and densitometric parameters of fracture healing.
abstract: OBJECTIVE
  In this study we evaluated the effects of montelukast, a leukotriene-receptor antagonist, on fracture healing, and investigated the hypothesis that enhanced fracture healing would be observed with montelukast in a rat tibia fracture model.
  
  
  METHODS
  Sixty adult (6 months old) female Wistar albino rats (mean weight 220 g, range 210-270 g) were randomly divided into two groups: a montelukast group (n=30) and a control group (n=30). Closed tibia fractures were created and fixed by intramedullary Kirschner wire. The rats were sacrificed three and six weeks after the fractures. Radiological and histological evaluations were performed, and bone mineral density was measured.
  
  
  RESULTS
  Three rats died in the montelukast group, whereas only one died in the control group during the study. Initial weight and weight gain at the 3rd and 6th weeks were not significantly different between the groups (p>0.05). Bone mineral densities in the control and study groups were 0.13±0.009 gr/cm2, and 0.13±0.01 gr/cm2 at week three and 0.16±0.02 gr/cm2, and 0.13±0.01 gr/cm2 at week six, respectively. Histopathological scores in the control and study groups were 3.42±0.6, and 3.0±0.0 at week three and 3.5±0.5, and 3.4±0.8 at week six, respectively. Radiological scores in the control and study groups were 1.19±0.6, and 1.0±0.6 at week three and 3.0±0.8, and 2.9±0.9 at week six, respectively. There were no significant differences between the two groups in any parameters evaluated at either time interval (p>0.05).
  
  
  CONCLUSIONS
  Our study failed to show a possible positive effect of leukotriene receptor inhibition on fracture healing at the 3rd and 6th postoperative weeks.
authors.affiliation: Department of Orthopedics and Traumatology, Medicine Faculty of Abant İzzet Baysal University, Bolu, Turkey. hcakici@gmail.com
authors.forename: Hüsamettin
authors.initials: H
authors.lastname: Cakıcı
authors.forename: Onur
authors.initials: O
authors.lastname: Hapa
authors.forename: Kaan
authors.initials: K
authors.lastname: Gideroğlu
authors.forename: Kutay
authors.initials: K
authors.lastname: Ozturan
authors.forename: Melih
authors.initials: M
authors.lastname: Güven
authors.forename: Halil Yalçın
authors.initials: HY
authors.lastname: Yüksel
authors.forename: Fahri
authors.initials: F
authors.lastname: Yılmaz
mesh_terms: D015502:Absorptiometry, Photon; D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D003521:Cyclopropanes; D005260:Female; D017102:Fracture Healing / Q000187:drug effects*; D005596:Fractures, Closed / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D020024:Leukotriene Antagonists / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000085:Acetates; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast