title: Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands.
abstract: It has been 15 years since we proposed the defective ribosomal product (DRiP) hypothesis to explain the rapid presentation of viral peptides by MHC class I molecules on the surface of infected cells. Here, we review the evidence for the contribution of DRiPs to antigen processing, pointing to the uncertainties regarding the physical nature of DRiPs, and emphasizing recent findings suggesting that peptide generation is a specialized process involving compartmentalized translation.
authors.affiliation: Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Dolan
authors.forename: Jack R
authors.initials: JR
authors.lastname: Bennink
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Yewdell
mesh_terms: D017951:Antigen Presentation / Q000276:immunology; D004721:Endoplasmic Reticulum / Q000276:immunology / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis* / Q000276:immunology*; D006801:Humans; D014176:Protein Biosynthesis; D014777:Virus Diseases / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I