title: Therapeutic effects of proanthocyanidins on the pathogenesis of periodontitis--an overview.
abstract: Periodontitis is a bacterially induced chronic inflammatory disease that destroys the connective tissue and bone that support teeth. Bacteria initiates periodontitis and destruction of the alveolar bone and periodontal connective tissue is clearly observed. But, the events occuring between these two points of time remain obscure and this study focusses on these aspects. The proanthocyanidins (PC) have variable pharmacological and nutraceutical benefits including improvement of ischemic cardiovascular disease, prevention of atherosclerosis and antiarthritic, anticancer and antimicrobial activities. The benefits associated with the antioxidant activity of PC have been evaluated both in vivo and in vitro. But, reports on the ameliorative effects of PC on oral diseases and specifically on periodontitis are very few. Hence, a novel attempt is made to review the possible protective effects of PC and its mechanism of action in periodontitis and also to show whether PC could be developed as a therapeutic agent for periodontitis.
authors.affiliation: Department of Biochemistry, Meenakshi Ammal Dental College, Alapakkam Main Road, Maduravoyal, Chennai 600 095, India.
authors.forename: Jayamathi
authors.initials: J
authors.lastname: Govindaraj
authors.forename: Pamela
authors.initials: P
authors.lastname: Emmadi
authors.forename: Rengarajulu
authors.initials: R
authors.lastname: Puvanakrishnan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008264:Macrophages / Q000473:pathology / Q000502:physiology; D008954:Models, Biological; D009504:Neutrophils / Q000473:pathology / Q000502:physiology; D010518:Periodontitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D044945:Proanthocyanidins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D017382:Reactive Oxygen Species / Q000009:adverse effects / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D044945:Proanthocyanidins; D017382:Reactive Oxygen Species