title: Acaricidal properties of the essential oil and precocene II obtained from Calea serrata (Asteraceae) on the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).
abstract: Calea serrata Less. (Asteraceae), an endemic species of south Brazil known as "quebra-tudo", is used in Afro-Brazilian religious rituals and in folk medicine for treating liver disorders. Phytochemical studies of the n-hexane extract of this plant demonstrated the presence of precocene II, a benzopyran derivative known for its insecticidal activity. The aim of this work was to isolate this benzopyran and determine the chemical composition of the essential oil of C. serrata and further to evaluate the acaricidal activity of the essential oil and precocene II against the larvae of Rhipicephalus (Boophilus) microplus. The LC(99.9) and LC(50) values obtained with the oil, which presents precocene II and sesquiterpenes, were 3.94 μL/mL and 0.28 μL/mL, respectively. For precocene II this values were 4.25mg/mL and 1.78 mg/mL, respectively. The results indicate a synergistic interaction between the components of the oil and precocene II.
authors.affiliation: PPG-Bioquímica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, 90035-000 Porto Alegre, RS, Brazil.
authors.forename: Vera Lucia Sardá
authors.initials: VL
authors.lastname: Ribeiro
authors.forename: Jaqueline Campiol
authors.initials: JC
authors.lastname: dos Santos
authors.forename: João Ricardo
authors.initials: JR
authors.lastname: Martins
authors.forename: Jan
authors.initials: J
authors.lastname: Schripsema
authors.forename: Ionara R
authors.initials: IR
authors.lastname: Siqueira
authors.forename: Gilsane L
authors.initials: GL
authors.lastname: von Poser
authors.forename: Miriam A
authors.initials: MA
authors.lastname: Apel
mesh_terms: D056810:Acaricides / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001578:Benzopyrans / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007814:Larva / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D048494:Rhipicephalus / Q000187:drug effects*
chemical_list: D056810:Acaricides; D001578:Benzopyrans; D009822:Oils, Volatile; D010938:Plant Oils; C014163:precocene II