title: In vitro production of transfusable red blood cells.
abstract: Unpredictable adverse results can ensue from blood transfusion therapies because of the donation of cells from a very large number of anonymous volunteers. There is little doubt that transfusable blood cells produced on a large scale in vitro would be candidate materials to replace cells donated from such a large group of anonymous individuals. The recent progress of technology for in vitro production of transfusable red blood cells is reviewed.
authors.affiliation: Cell Engineering Division, RIKEN BioResource Center, Koyadai 3-1-1, Tsukuba, Ibaraki, 305-0074, Japan. yukionak@brc.riken.jp
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001698:Biomedical Engineering / Q000379:methods*; D018929:Cell Culture Techniques / Q000379:methods*; D002460:Cell Line; D053595:Embryonic Stem Cells / Q000166:cytology; D017707:Erythrocyte Transfusion / Q000009:adverse effects; D004912:Erythrocytes / Q000166:cytology*; D015672:Erythroid Precursor Cells / Q000166:cytology; D004920:Erythropoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D051379:Mice