title: Hematological response of pancytopenia to glucocorticoids in patients with Sheehan's syndrome.
abstract: Sheehan's syndrome presents with panhypopituitarism after childbirth, usually preceded by post partum hemorrhage. Hematological abnormalities like pancytopenia with hypocellular marrow in these patients are reported rarely. Though multiple hormone deficiencies may contribute to Pancytopenia in Sheehan's syndrome, complete recovery is observed after achieving eucortisolemic and euthyroid state. The predominant role of thyroxine or glucocorticoids in reversing pancytopenia in these patients has not been studied. We present the clinical, hormonal, hematological course and response to glucocorticoids in a patient of Sheehan's syndrome presenting with pancytopenia. Complete recovery of pancytopenia was observed after achieving eucortisolemic state thus concluding that gulcocorticoid replacement is sufficient to reverse pancytopenia in these patients.
authors.affiliation: Department of Endocrinology, Sher-I- Kashmir Institute of Medical Sciences Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Laway
authors.forename: Shahnaz Ahmad
authors.initials: SA
authors.lastname: Mir
authors.forename: Javid Rasool
authors.initials: JR
authors.lastname: Bhat
authors.forename: Mohd Iqbal
authors.initials: MI
authors.lastname: Lone
authors.forename: Jeelani
authors.initials: J
authors.lastname: Samoon
authors.forename: Abdul Hamid
authors.initials: AH
authors.lastname: Zargar
mesh_terms: D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000150:complications*; D010198:Pancytopenia / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy
chemical_list: D005938:Glucocorticoids