title: Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa.
abstract: Pseudomonas aeruginosa produces a biofilm that provides the bacteria with an effective barrier against antibiotics. Here, we investigated the synergy of various antibiotics with 14-alpha-lipoyl andrographolide (AL-1), focusing upon synthesis of the biofilm. AL-1 also inhibited the production of the exopolysaccharide and pyocyanin components. We propose that AL-1 may potentially serve as a cotherapy to combat P. aeruginosa.
authors.affiliation: Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China.
authors.forename: Xiangping
authors.initials: X
authors.lastname: Zeng
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Liu
authors.forename: Jiang
authors.initials: J
authors.lastname: Bian
authors.forename: Gang
authors.initials: G
authors.lastname: Pei
authors.forename: Huanqin
authors.initials: H
authors.lastname: Dai
authors.forename: Steven W
authors.initials: SW
authors.lastname: Polyak
authors.forename: Fuhang
authors.initials: F
authors.lastname: Song
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D004224:Diterpenes / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism; D011710:Pyocyanine / Q000096:biosynthesis*; D053038:Quorum Sensing
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D011135:Polysaccharides, Bacterial; C030419:andrographolide; D011710:Pyocyanine