title: Primary embryonal rhabdomyosarcoma of the prostate in adults: report of a case and review of the literature.
abstract: This study reports on a case of an adult patient with embryonal rhabdomyosarcoma of the prostate and comprehensively reviews the world literature on this subject. The patient was a 49-year-old man with advanced stage disease, who initially underwent transurethral tumor resection and after diagnosis was given courses of chemotherapy prior to undergoing radical cystoprostatevesiculectomy. The tumor underwent histological examination supplemented by immunohistochemical analysis. After surgery, the patient experienced a huge pelvic recurrence and eventually died of disease 1 year after the original diagnosis. The world literature was reviewed based both on a PubMed/Medline search and the reference lists of all the available publications on this subject and only 24 cases of primary embryonal prostatic rhabdomyosarcoma have been found in the world literature in adult males (≥ 18 years). Embryonal rhabdomyosarcoma of the prostate in adults is a very rare and aggressive disease. The long-term disease-specific survival rate is poor. Stage influences the outcome. Early diagnosis and complete surgical resection offer patients the best chance of improved survival.
authors.affiliation: Department of Pathology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy. bismi@libero.it
authors.forename: Michele
authors.initials: M
authors.lastname: Bisceglia
authors.forename: Gaetano
authors.initials: G
authors.lastname: Magro
authors.forename: Illuminato
authors.initials: I
authors.lastname: Carosi
authors.forename: Vito
authors.initials: V
authors.lastname: Cannazza
authors.forename: David
authors.initials: D
authors.lastname: Ben Dor
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D035583:Rare Diseases; D018233:Rhabdomyosarcoma, Embryonal / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor