title: A reconstruction with extracorporeal irradiated autograft in osteosarcoma around the knee.
abstract: OBJECTIVE
  An extracorporeal irradiated (ECI) autograft was first reported in Israel in 1968 for the treatment of primary malignant bone tumor. However, subsequent reports covered mostly short-term follow up results, and the reported results of reconstruction vary from study to study. We analyze the long-term follow up results of reconstruction using an extracorporeal irradiated (ECI) autograft in osteosarcoma around the knee.
  
  
  METHODS
  We retrospectively reviewed 23 osteosarcoma patients who underwent reconstruction with ECI between December 1995 and April 2005. The 15 males and 8 females had a mean age of 21 years (range: 7-74) and a mean follow-up of 127 months(range: 57-170). Tumors were located in the distal femur in 14 cases, and the proximal tibia in 9 cases. Pathological types were conventional in 22 cases, and parosteal in 1 case. Resection methods were osteoarticular in 18 cases and total joint in 5 cases. Eighteen cases were reconstructed with the ECI autograft and five with ECI autograft-prosthesis composite (APC). The Musculoskeletal Tumor Society (MSTS) score was used for functional evaluation. The overall survival rate, local recurrence, complications were analyzed.
  
  
  RESULTS
  The overall survival rate was 82.6%, and the disease-free survival rate was 69.5%. We found 20 complications, including 6 nonunions, 5 deep infections, 4 joint instabilities, 2 fractures, 1 limb-length discrepancy (LLD), 1 epiphyseal collapse, and 1 vessel occlusion. The average MSTS functional score was 62.6%.
  
  
  CONCLUSIONS
  Reconstruction with an extracorporeal irradiated is not recommended for osteosarcoma around the knee.
authors.affiliation: Department of Orthopedic Surgery, Kosin University Gospel Hospital, Busan, Korea.
authors.forename: Jae-Do
authors.initials: JD
authors.lastname: Kim
authors.forename: Gun Woo
authors.initials: GW
authors.lastname: Lee
authors.forename: So Hak
authors.initials: SH
authors.lastname: Chung
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D016025:Bone Transplantation; D002648:Child; D005260:Female; D005269:Femur; D005500:Follow-Up Studies; D006801:Humans; D007717:Knee; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000379:methods*; D012516:Osteosarcoma / Q000532:radiotherapy* / Q000601:surgery*; D019651:Plastic Surgery Procedures; D012092:Replantation; D012189:Retrospective Studies; D013977:Tibia; D014182:Transplantation, Autologous; D055815:Young Adult