title: Modeling particle shape-dependent dynamics in nanomedicine.
abstract: One of the major challenges in nanomedicine is to improve nanoparticle cell selectivity and adhesion efficiency through designing functionalized nanoparticles of controlled sizes, shapes, and material compositions. Recent data on cylindrically shaped filomicelles are beginning to show that non-spherical particles remarkably improved the biological properties over spherical counterpart. Despite these exciting advances, non-spherical particles have not been widely used in nanomedicine applications due to the lack of fundamental understanding of shape effect on targeting efficiency. This paper intends to investigate the shape-dependent adhesion kinetics of non-spherical nanoparticles through computational modeling. The ligand-receptor binding kinetics is coupled with Brownian dynamics to study the dynamic delivery process of nanorods under various vascular flow conditions. The influences of nanoparticle shape, ligand density, and shear rate on adhesion probability are studied. Nanorods are observed to contact and adhere to the wall much easier than their spherical counterparts under the same configuration due to their tumbling motion. The binding probability of a nanorod under a shear rate of 8 s(-1) is found to be three times higher than that of a nanosphere with the same volume. The particle binding probability decreases with increased flow shear rate and channel height. The Brownian motion is found to largely enhance nanoparticle binding. Results from this study contribute to the fundamental understanding and knowledge on how particle shape affects the transport and targeting efficiency of nanocarriers, which will provide mechanistic insights on the design of shape-specific nanomedicine for targeted drug delivery applications.
authors.affiliation: Department of Mechanical and Aerospace Engineering, The University of Texas at Arlington, Arlington, TX 76019, USA.
authors.forename: Samar
authors.initials: S
authors.lastname: Shah
authors.forename: Yaling
authors.initials: Y
authors.lastname: Liu
authors.forename: Walter
authors.initials: W
authors.lastname: Hu
authors.forename: Jinming
authors.initials: J
authors.lastname: Gao
mesh_terms: D000268:Adhesiveness; D016503:Drug Delivery Systems; D057446:Hydrodynamics; D007700:Kinetics; D008024:Ligands; D008958:Models, Molecular; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size
chemical_list: D008024:Ligands