title: Analysis of the 8.1 ancestral MHC haplotype in severe, pneumonia-related sepsis.
abstract: The most frequent Caucasian MHC haplotype, AH8.1 - associated with numerous immunopathological differences and certain autoimmune diseases - was recently linked to the delayed onset of bacterial colonization in cystic fibrosis. Based on this observation, we hypothesized that the carriers of AH8.1 have lower risk for a worse outcome in sepsis. AH8.1 carrier state was determined in 207 Caucasian patients with severe, pneumonia-related sepsis. Our data showed that in patients without chronic obstructive pulmonary disease (COPD), septic shock - a serious consequence of the bacterial infection - occurred significantly less frequently (OR=0.3383; 95% CI=0.1141-0.995; p=0.043) in carriers of AH8.1, than in non-carriers. According to the multivariate logistic regression analysis, this haplotype had an independent protective role against septic shock in all patients (OR=0.315; 95% CI=0.100-0.992; p=0.048), particularly in COPD-free patients (OR=0.117; 95% CI=0.025-0.554; p=0.007). These results indicate that AH8.1 may confer protection against the progression of bacterial infection, and this could explain, at least partially, its high frequency in the Caucasian population.
authors.affiliation: 3rd Department of Internal Medicine, Research Laboratory, Semmelweis University, Budapest, Hungary. aladzsityistvan@yahoo.com
authors.forename: István
authors.initials: I
authors.lastname: Aladzsity
authors.forename: Krisztina
authors.initials: K
authors.lastname: Madách
authors.forename: Agnes
authors.initials: A
authors.lastname: Szilágyi
authors.forename: János
authors.initials: J
authors.lastname: Gál
authors.forename: István
authors.initials: I
authors.lastname: Pénzes
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Prohászka
authors.forename: George
authors.initials: G
authors.lastname: Fust
mesh_terms: D000368:Aged; D015331:Cohort Studies; D004247:DNA / Q000737:chemistry / Q000235:genetics; D014644:Genetic Variation; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000097:blood / Q000235:genetics* / Q000276:immunology; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D018805:Sepsis / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000382:microbiology
chemical_list: D006680:HLA Antigens; D004247:DNA