title: Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
abstract: The risk of Alzheimer's disease increases following cerebral hypoperfusion. We studied the long-term interaction between low blood flow to the brain and Alzheimer's disease by inducing a transient global ischemic insult in aged 3xTg-AD mice and determining the effects on AD pathology 3-months post injury. We found that global ischemia does not increase the levels of amyloid-β in these mice. However, the injury did lead to enhanced phosphorylation of the amyloid precursor protein (APP) at the Thr668 site in both the 3xTg-AD mice and wild-type controls. Furthermore, we found an increase in insoluble total tau 3-months post-injury. Together these findings further elucidate the long-term impact of cerebral hypoperfusion on Alzheimer's disease.
authors.affiliation: Department of Neurobiology and Behavior, University of California, Irvine, CA, United States.
authors.forename: M A
authors.initials: MA
authors.lastname: Koike
authors.forename: F G
authors.initials: FG
authors.lastname: Garcia
authors.forename: M
authors.initials: M
authors.lastname: Kitazawa
authors.forename: K N
authors.initials: KN
authors.lastname: Green
authors.forename: F M
authors.initials: FM
authors.lastname: Laferla
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000209:etiology / Q000378:metabolism*; D017536:Carotid Artery, Common / Q000473:pathology; D016893:Carotid Stenosis / Q000150:complications; D051379:Mice; D008822:Mice, Transgenic; D010766:Phosphorylation; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D016875:tau Proteins