title: Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients.
abstract: OBJECTIVE
  Increasing evidence supports a parallel between HIV-1 infection and immune aging, which is particularly apparent with common changes in naive versus memory T-cell proportions. Here, we aimed at refining the value of common T-cell-associated markers of immunosenescence during HIV disease progression or aging, and at exploring further the impact in this context of old age as well as cytomegalovirus (CMV) co-infection, which is predominant in HIV-1-infected individuals.
  
  
  METHODS
  Frequencies of naive or CD57(+) memory T cells as well as the magnitude of CMV-pp65 T cells were measured in HIV-1-infected patients grouped according to disease progression status, treatment and age.
  
  
  RESULTS
  Our results indicate that the decline in naive T-cell levels rather than the accumulation of CD57(+) senescent T cells identifies best the premature development of an immunosenescence phenotype with HIV disease progression. Moreover, advanced age or mounting of strong CMV-specific responses impact independently on CD4(+) T-cell counts and recovery with antiretroviral therapy.
  
  
  CONCLUSIONS
  The present findings indicate that HIV-1 infection amplifies the effect of age on naive T-cell levels, and highlight the constraint on the capacity of treated patients to reconstitute their CD4(+) T-cell compartment due to age and CMV co-infection.
authors.affiliation: INSERM UMR S, Infections and Immunity, Avenir Group, Université Pierre et Marie Curie-Paris, Hôpital Pitié-Salpêtrière, France. victor.appay@upmc.fr
authors.forename: Victor
authors.initials: V
authors.lastname: Appay
authors.forename: Solène
authors.initials: S
authors.lastname: Fastenackels
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Hocine
authors.initials: H
authors.lastname: Ait-Mohand
authors.forename: Luminita
authors.initials: L
authors.lastname: Schneider
authors.forename: Amélie
authors.initials: A
authors.lastname: Guihot
authors.forename: Michael
authors.initials: M
authors.lastname: Keller
authors.forename: Beatrix
authors.initials: B
authors.lastname: Grubeck-Loebenstein
authors.forename: Anne
authors.initials: A
authors.lastname: Simon
authors.forename: Olivier
authors.initials: O
authors.lastname: Lambotte
authors.forename: Peter W
authors.initials: PW
authors.lastname: Hunt
authors.forename: Steven G
authors.initials: SG
authors.lastname: Deeks
authors.forename: Dominique
authors.initials: D
authors.lastname: Costagliola
authors.forename: Brigitte
authors.initials: B
authors.lastname: Autran
authors.forename: Delphine
authors.initials: D
authors.lastname: Sauce
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016922:Cellular Senescence / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral