title: Task-related oxygen uptake during domestic activities of daily life in patients with COPD and healthy elderly subjects.
abstract: BACKGROUND
  Patients with COPD generally have a poor peak aerobic capacity and, therefore, may experience more inconvenience during domestic activities of daily life (ADLs). Yet, task-related oxygen uptake and symptom perception during ADLs have been studied rarely in COPD. Therefore, it remains unknown whether and to what extent differences may exist in task-related oxygen uptake and symptom perception during ADLs in patients with COPD after stratification for sex; GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage; Medical Research Council (MRC) dyspnea grade; or score on the BMI, obstruction, dyspnea, exercise capacity (BODE) index.
  
  
  METHODS
  Ninety-seven patients with COPD and 20 healthy elderly subjects performed the following five self-paced domestic ADLs with 4-min rest intervals: putting on socks, shoes, and vest; folding eight towels; putting away groceries; washing four dishes, cups, and saucers; and sweeping the floor for 4 min. Task-related oxygen uptake was assessed using an Oxycon Mobile device, whereas Borg scores were used to assess task-related dyspnea and fatigue.
  
  
  RESULTS
  Patients with COPD used a significantly higher proportion of their peak aerobic capacity and ventilation to perform ADLs than did the healthy subjects, accompanied by higher task-related Borg dyspnea scores. Patients with GOLD stage IV, MRC dyspnea grade 5, or BODE score ≥ 6 points had the highest task-related oxygen uptake and dyspnea perception during the performance of domestic ADLs. Results showed no sex-related differences.
  
  
  CONCLUSIONS
  Patients with COPD experience a relatively high metabolic load and symptom perception during the performance of ADLs that is not the same as seen in their healthy peers, particularly in patients with GOLD stage IV, MRC dyspnea grade 5, or BODE score ≥ 6 points.
authors.affiliation: Program Development Centre, CIRO+, Horn, The Netherlands; Physiotherapy, CIRO+, Horn, The Netherlands. Electronic address: anoukvaes@ciro-horn.nl.
authors.forename: Anouk W
authors.initials: AW
authors.lastname: Vaes
authors.affiliation: Program Development Centre, CIRO+, Horn, The Netherlands; Respiratory Medicine, School for Nutrition, Toxicology and Metabolism, MUMC+, Maastricht, The Netherlands.
authors.forename: Emiel F M
authors.initials: EFM
authors.lastname: Wouters
authors.affiliation: Program Development Centre, CIRO+, Horn, The Netherlands.
authors.forename: Frits M E
authors.initials: FME
authors.lastname: Franssen
authors.affiliation: Cardiology, School for Nutrition, Toxicology and Metabolism, MUMC+, Maastricht, The Netherlands.
authors.forename: Nicole H M K
authors.initials: NHMK
authors.lastname: Uszko-Lencer
authors.affiliation: Program Development Centre, CIRO+, Horn, The Netherlands.
authors.forename: Koen H P
authors.initials: KHP
authors.lastname: Stakenborg
authors.affiliation: Department of Human Movement Science, School for Nutrition, Toxicology and Metabolism, MUMC+, Maastricht, The Netherlands.
authors.forename: Marlies
authors.initials: M
authors.lastname: Westra
authors.affiliation: Department of Human Movement Science, School for Nutrition, Toxicology and Metabolism, MUMC+, Maastricht, The Netherlands.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Meijer
authors.affiliation: Respiratory Medicine, School for Nutrition, Toxicology and Metabolism, MUMC+, Maastricht, The Netherlands.
authors.forename: Annemie M W J
authors.initials: AMWJ
authors.lastname: Schols
authors.affiliation: Program Development Centre, CIRO+, Horn, The Netherlands.
authors.forename: Paul P
authors.initials: PP
authors.lastname: Janssen
authors.affiliation: Program Development Centre, CIRO+, Horn, The Netherlands.
authors.forename: Martijn A
authors.initials: MA
authors.lastname: Spruit
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D016022:Case-Control Studies; D004417:Dyspnea / Q000503:physiopathology; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012123:Pulmonary Ventilation / Q000502:physiology; D012720:Severity of Illness Index; D013647:Task Performance and Analysis