title: Do reactive oxygen species play a role in myeloid leukemias?
abstract: Reactive oxygen species (ROS) are a heterogeneous group of molecules that are generated by mature myeloid cells during innate immune responses, and are also implicated in normal intracellular signaling. Excessive production of ROS (and/or a deficiency in antioxidant pathways) can lead to oxidative stress, a state that has been observed in several hematopoietic malignancies including acute and chronic myeloid leukemias (AML and CML). Currently it is unclear what the cause of oxidative stress might be and whether oxidative stress contributes to the development, progression, or maintenance of these diseases. This article reviews the current evidence suggesting a role for ROS both in normal hematopoiesis and in myeloid leukemogenesis, and discusses the usefulness of therapeutically targeting oxidative stress in myeloid malignancy.
authors.affiliation: Department of Medical Genetics, Haematology and Pathology, School of Medicine, Cardiff University, Cardiff, United Kingdom.
authors.forename: Paul Spencer
authors.initials: PS
authors.lastname: Hole
authors.forename: Richard Lawrence
authors.initials: RL
authors.lastname: Darley
authors.forename: Alex
authors.initials: A
authors.lastname: Tonks
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species