title: Osteoblastic osteosarcoma in monostotic Paget's disease.
abstract: Paget's disease is a disorder of bone remodelling affecting 1-2% of the general population, most frequently men over 50 years of age. Sarcomatous degeneration occurs in 0.1-0.95% of patients with Paget's disease. It can be observed in monostotic and polyostotic disease. Osteosarcomas account for more than 80% of pagetic sarcomas; osteoblastic pagetic osteosarcomas are rare. In this article, we present the case of a 75-year-old man with secondary osteosarcoma arising in monostotic Paget's disease, initially misdiagnosed as rotator cuff tendinopathy. Imaging studies and biopsy were diagnostic.
authors.affiliation: Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Bologna, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Calabrò
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Mavrogenis
authors.forename: Pietro
authors.initials: P
authors.lastname: Ruggieri
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D003937:Diagnosis, Differential; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D023821:Limb Salvage / Q000379:methods; D008297:Male; D010001:Osteitis Deformans / Q000150:complications*; D010006:Osteoblasts / Q000473:pathology; D012516:Osteosarcoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D011859:Radiography; D016896:Treatment Outcome