title: Making new out of old: recycling and modification of an ancient protein translocation system during eukaryotic evolution. Mechanistic comparison and phylogenetic analysis of ERAD, SELMA and the peroxisomal importomer.
abstract: At first glance the three eukaryotic protein translocation machineries--the ER-associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre-protein translocator of complex plastids--appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre-existing components as an effective evolutionary driving force. Editor's suggested further reading in BioEssays ERAD ubiquitin ligases Abstract.
authors.affiliation: Laboratory for Cell Biology, Philipps-University of Marburg, Marburg, Germany. kathrin.bolte@staff.uni-marburg.de
authors.forename: Kathrin
authors.initials: K
authors.lastname: Bolte
authors.forename: Nicole
authors.initials: N
authors.lastname: Gruenheit
authors.forename: Gregor
authors.initials: G
authors.lastname: Felsner
authors.forename: Maik S
authors.initials: MS
authors.lastname: Sommer
authors.forename: Uwe-G
authors.initials: UG
authors.lastname: Maier
authors.forename: Franziska
authors.initials: F
authors.lastname: Hempel
mesh_terms: D005075:Biological Evolution; D003600:Cytosol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D016013:Likelihood Functions; D008954:Models, Biological; D020675:Peroxisomes / Q000378:metabolism*; D018087:Plastids / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology*