title: The rationality for using prodrug approach in drug discovery programs for new xenobiotics: opportunities and challenges.
abstract: The concept of prodrugs has been successfully executed for life cycle management options of several approved drugs and drugs in development. In addition to imparting ideal biopharmaceutical properties, such as solubility, permeability and lipophilicity, some prodrug concepts have also enabled site-specific drug delivery, prolonged the duration of therapeutic effect and improved therapeutic index. The strategic inclusion of prodrug concept during drug discovery and early development process brings in some unique challenges. The communication provides balanced perspectives on the rational use and challenges of prodrug concept during the drug discovery and development process.
authors.affiliation: Vanthys Pharmaceutical Development Ltd, Bangalore, India. nuggehally.srinivas@vanthys.net
authors.forename: Nuggehally R
authors.initials: NR
authors.lastname: Srinivas
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D010601:Pharmacology, Clinical / Q000639:trends; D011355:Prodrugs; D015262:Xenobiotics / Q000494:pharmacology*
chemical_list: D011355:Prodrugs; D015262:Xenobiotics