title: Severe nasal presentation of antiphospholipid syndrome.
abstract: We report a rare and severe nasal presentation of antiphospholipid syndrome in a 41-year-old man with systemic lupus erythematosus and end-stage renal disease. His nasal signs included total septal necrosis, along with external nasal swelling and erythema. Prior to the correct diagnosis, multiple medical and surgical treatments were attempted without success. After initiation of intravenous immunoglobulin and anticoagulation therapy, his nasal symptoms promptly resolved. The nasal complication of antiphospholipid syndrome is a relatively unknown and rare finding with limited discussion in the otolaryngology literature.
authors.affiliation: Department of Head and Neck Surgery, Kaiser Permanente Medical Center, 280 W MacArthur Blvd, Oakland, CA 94611, USA.
authors.forename: Ji-Eon
authors.initials: JE
authors.lastname: Kim
authors.forename: Shivan H
authors.initials: SH
authors.lastname: Amin
authors.forename: Dean
authors.initials: D
authors.lastname: Fong
authors.forename: Sumeer K
authors.initials: SK
authors.lastname: Gupta
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004724:Endoscopy; D005500:Follow-Up Studies; D006801:Humans; D007116:Immunization, Passive; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000628:therapy; D008181:Lupus Nephritis / Q000175:diagnosis / Q000628:therapy; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology; D009300:Nasal Septum / Q000473:pathology; D009336:Necrosis; D009668:Nose Diseases / Q000175:diagnosis* / Q000628:therapy; D014420:Turbinates / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D000925:Anticoagulants