title: Inducible gene expression in mammals: plants add to the menu.
abstract: Achieving inducible gene expression in mammalian cells with inexpensive and nontoxic inducers is an ongoing quest. The plant hormone abscisic acid has now been added to the list of compounds that can be used for regulating transcription and controlling protein function by induced proximity. These advances may enable new clinical applications of proximity-induced systems, and they highlight the value of fundamental research in plant biology.
authors.affiliation: Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California Riverside, Riverside, CA 92507, USA. sean.cutler@ucr.edu
authors.forename: Sean R
authors.initials: SR
authors.lastname: Cutler
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D008322:Mammals / Q000235:genetics*; D008954:Models, Biological; D010937:Plant Growth Regulators / Q000378:metabolism / Q000494:pharmacology; D010944:Plants / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D010937:Plant Growth Regulators; D000040:Abscisic Acid