title: The protective effect of salicylic acid on lysozyme against riboflavin-mediated photooxidation.
abstract: As a metabolite of aspirin in vivo, salicylic acid was proved to protect lysozyme from riboflavin-mediated photooxidation in this study. The antioxidative properties of salicylic acid were further studied by using time-resolved laser flash photolysis of 355 nm. It can quench the triplet state of riboflavin via electron transfer from salicylic acid to the triplet state of riboflavin with a reaction constant of 2.25×10(9) M(-1) s(-1). Mechanism of antioxidant activities of salicylic acid on lysozyme oxidation was discussed. Salicylic acid can serve as a potential antioxidant to quench the triplet state of riboflavin and reduce oxidative pressure.
authors.affiliation: School of Life Science and Technology, Department of Chemistry, Tongji University, Shanghai, PR China. liangliang2419@126.com
authors.forename: Kun
authors.initials: K
authors.lastname: Li
authors.forename: Hongbao
authors.initials: H
authors.lastname: Wang
authors.forename: Lingli
authors.initials: L
authors.lastname: Cheng
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.forename: Shi-Long
authors.initials: SL
authors.lastname: Wang
mesh_terms: D000042:Absorption / Q000187:drug effects / Q000528:radiation effects; D000975:Antioxidants / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D007700:Kinetics; D007834:Lasers; D008027:Light; D008956:Models, Chemical; D009113:Muramidase / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D010782:Photolysis / Q000187:drug effects / Q000528:radiation effects; D020011:Protective Agents / Q000494:pharmacology*; D012256:Riboflavin / Q000494:pharmacology*; D020156:Salicylic Acid / Q000494:pharmacology*; D012996:Solutions; D013057:Spectrum Analysis; D013997:Time Factors
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D012996:Solutions; D009113:Muramidase; D020156:Salicylic Acid; D012256:Riboflavin