title: Influence of the tumor microenvironment on angiogenesis.
abstract: It is becoming increasingly recognized that the host microenvironment is essential for regulating tumor cell behavior. The cellular stromal compartment can modulate angiogenesis either directly through enhanced secretion of pro-angiogenic factors or reduced secretion of antiangiogenic factors, or indirectly by modulating the surrounding extracellular matrix. Control of angiogenesis represents a critical step in cancer progression and is a potential therapeutic target. This article focuses on the role of the tumor microenvironment in the control of angiogenesis and how dissection of the molecular interactions may enhance prognostic and predictive power and facilitate therapeutic targeting.
authors.affiliation: Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK. sarahpayne75@yahoo.co.uk
authors.forename: Sarah J L
authors.initials: SJ
authors.lastname: Payne
authors.forename: Louise
authors.initials: L
authors.lastname: Jones
mesh_terms: D043924:Angiogenesis Modulating Agents / Q000378:metabolism; D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D009000:Monocytes / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000473:pathology; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D059016:Tumor Microenvironment
chemical_list: D043924:Angiogenesis Modulating Agents