title: Facile amide bond formation from carboxylic acids and isocyanates.
abstract: A wide variety of carboxylic acids in the form of their salts condense with aryl isocyanates at room temperature with loss of carbon dioxide to give the corresponding amides in high yield. Application of the reaction to acyl isocyanates gives unsymmetric imides. The reaction is compatible with hydroxyl groups and both Fmoc and Boc protecting groups for amines and is applicable to aliphatic, aromatic, and heteroaromatic acids.
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91190 Gif-sur-Yvette, France.
authors.forename: Kaname
authors.initials: K
authors.lastname: Sasaki
authors.forename: David
authors.initials: D
authors.lastname: Crich
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000737:chemistry*; D017953:Isocyanates / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D017953:Isocyanates