title: [Molecular mechanism of the acquisition of new-quinolone resistance in Mycobacterium leprae and M. tuberculosis and rapid differentiation methods for resistant bacilli].
abstract: Drugs included in new-quinolone are used for the treatment of leprosy with single lesion. These drugs are also known to be effective drugs for the treatment of multi-drug resistant M. tuberculosis. Recent emergence of new-quinolone resistant M. leprae and M. tuberculosis enforced the urgent elucidation of the mode of emergence of new-quinolone resistant strains. In this review, new-quinolone drugs, their mode of action and mechanism of acquisition of resistance by M. leprae and M. tuberculosis were explained. And rapid differentiation methods for resistant bacilli were also introduced.
authors.affiliation: Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Japan.
authors.forename: Hyun
authors.initials: H
authors.lastname: Kim
authors.forename: Haruka
authors.initials: H
authors.lastname: Suzuki
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsuoka
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuba
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Chie
authors.initials: C
authors.lastname: Nakajima
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001431:Bacteriological Techniques / Q000379:methods*; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D008826:Microbial Sensitivity Tests / Q000379:methods; D009154:Mutation; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification*; D015363:Quinolones / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones; D059005:Topoisomerase II Inhibitors; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase