title: Micro-organ ovarian transplantation enables pregnancy: a case report.
abstract: A 19-year-old thalassemic woman had tissue from one of her ovaries cryopreserved prior to bone marrow transplantation, total body irradiation and sterilizing chemotherapy. As expected, premature ovarian failure resulted from this treatment. Transplantation of her thawed ovarian tissue resulted in return of menstrual cycling and the patient then underwent several IVF cycles. The patient, however, had poor ovarian response to hyperstimulation. We thus considered an alternative approach based on the observation that very thin ovarian fragments that preserve the basic ovarian structure [ovarian micro-organs (MOs)] induce angiogenesis and remained viable after autologous transplantation in animals. We report that preparation of autologous tiny ovarian fragments (MO)s and reimplantation into our patient resulted in IVF pregnancy and delivery of a healthy baby.
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah Medical Center and Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. arielrevel2@gmail.com
authors.forename: Ariel
authors.initials: A
authors.lastname: Revel
authors.forename: Neri
authors.initials: N
authors.lastname: Laufer
authors.forename: Assaf
authors.initials: A
authors.lastname: Ben Meir
authors.forename: Meital
authors.initials: M
authors.lastname: Lebovich
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mitrani
mesh_terms: D000328:Adult; D015925:Cryopreservation; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D010053:Ovary / Q000637:transplantation*; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000601:surgery; D013789:Thalassemia / Q000150:complications; D014182:Transplantation, Autologous / Q000379:methods; D014916:Whole-Body Irradiation / Q000009:adverse effects