title: Stanniocalcin 1 affects redox status of swine granulosa cells.
abstract: Stanniocalcin 1 (STC1) is a glycoprotein hormone expressed in different mammalian tissues. In previous studies, we showed STC1 expression in swine ovarian follicles and we demonstrated that STC1 may be a physiological regulator of follicular function. Since reactive oxygen species (ROS) are important signal transducers in the ovary, the present study was undertaken to investigate STC1 action on ROS generation and on the activity of the major enzymatic and non-enzymatic scavengers in swine granulosa cells. O(2)- generation, catalase activity and FRAP levels were increased by STC1, whereas H(2)O(2) generation and peroxidase activity were decreased by STC1. Taken together, our data show that STC1 modulates redox status in swine granulosa cells.
authors.affiliation: Dipartimento di Produzioni Animali, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti, Sezione di Fisiologia Veterinaria, Università degli Studi di Parma, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Baioni
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Basini
authors.forename: Simona
authors.initials: S
authors.lastname: Bussolati
authors.forename: Francesca
authors.initials: F
authors.lastname: Grasselli
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D049109:Cell Proliferation; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism / Q000494:pharmacology*; D006107:Granulosa Cells / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013552:Swine
chemical_list: D016166:Free Radical Scavengers; D006023:Glycoproteins; C051795:teleocalcin; D006861:Hydrogen Peroxide; D002374:Catalase; D009195:Peroxidase; D013482:Superoxide Dismutase