title: Multimodal superparamagnetic nanoplatform for clinical applications: immunoassays, imaging & therapy.
abstract: A new type of multifunctional magnetic nano-platform for bioassays, diagnosis and therapy applications was designed using superparamagnetic gammaFe(2)O(3) nanoparticles conjugated to hydroxylmethylene bisphosphonate (HMBPs) molecules. The nanoparticle has two essential roles: to act as a probe owing to its specific magnetic properties and to carry on its surface antitumoral molecules (therapeutic applications) or precursor groups for the covalent coupling of biological recognition molecules, such as antibodies, nucleic acids (in vitro & in vivo diagnosis).
authors.affiliation: Laboratoire CSPBAT, FRE 3043 CNRS Université Paris 13, 93017 Bobigny Cedex, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Motte
authors.forename: Farah
authors.initials: F
authors.lastname: Benyettou
authors.forename: Caroline
authors.initials: C
authors.lastname: de Beaucorps
authors.forename: Marc
authors.initials: M
authors.lastname: Lecouvey
authors.forename: Irena
authors.initials: I
authors.lastname: Milesovic
authors.forename: Yoann
authors.initials: Y
authors.lastname: Lalatonne
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods*; D004164:Diphosphonates / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D008280:Magnetics / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D004164:Diphosphonates; D005290:Ferric Compounds; C029285:hydroxymethanediphosphonic acid; C000499:ferric oxide