title: [Infections due to Mycobacterium marinum: a review].
abstract: Mycobacterium marinum belongs to the non-tuberculous or "atypical" mycobacteria. The reservoirs for these ubiquitous and slowly growing bacteria are both fresh water and salt water. In particular, aquaria should be considered as important source of hobby-related infections especially of fingers, hands and forearms. Affected are both immunosuppressed patients and persons with an intact immune system. Distinctive are erythematous plaques and nodules with tendency for hyperkeratosis, crusting, and superficial ulcerations, sometimes as sporotrichoid lymphocutaneous infection. The histology shows non-caseation granulomas containing epithelioid cells and Langhans giant cells. Using the Ziehl Neelsen staining, typical acid-fast rods are not always detectable. The molecular biological detection of mycobacterial DNA using polymerase chain reaction represents the standard method of diagnosis. Cryotherapy is frequently used as first treatment. For the often long-term tuberculostatic therapy, rifampicin, ethambutol, and clarithromycin are the most used agents.
authors.affiliation: Haut- und Laborarzt/Allergologie, Andrologie, Labor für medizinische Mikrobiologie, Straße des Friedens 8, 04579 Mölbis, Deutschland. nenoff@mykologie-experten.de
authors.forename: P
authors.initials: P
authors.lastname: Nenoff
authors.forename: B-M
authors.initials: BM
authors.lastname: Klapper
authors.forename: P
authors.initials: P
authors.lastname: Mayser
authors.forename: U
authors.initials: U
authors.lastname: Paasch
authors.forename: W
authors.initials: W
authors.lastname: Handrick
mesh_terms: D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D019910:Mycobacterium marinum; D017192:Skin Diseases, Bacterial / Q000175:diagnosis* / Q000382:microbiology* / Q000628:therapy