title: A-glucosidase inhibitory activity of kaempferol-3-O-rutinoside.
abstract: Quercetin, kaempferol and to a lesser extent rutin have been reported to have antidiabetic activities when assessed by various assay models including in vitro alpha-glucosidase inhibition studies. A related structural analogue, kaempferol-3-O-rutinoside (KR) however has not yet been studied for such biological effects. It was found that KR is a potent inhibitor of alpha-glucosidase in vitro with over 8-times more activity than the reference antidiabetic drug, acarbose. Furthermore, KR displayed a synergistic effect with a less potent flavonoid aglycones, kaempferol and quercetin. The structure-activity profile of these drugs and implications of drug combinations are discussed.
authors.affiliation: Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Chatham Maritime, Kent, ME4 4TB, United Kingdom. S.Habtemariam@gre.ac.uk
authors.forename: Solomon
authors.initials: S
authors.lastname: Habtemariam
mesh_terms: D020909:Acarbose / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000494:pharmacology; D044949:Kaempferols / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D044949:Kaempferols; C492687:kaempferol-3-O-rutinoside; D020909:Acarbose