title: The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration.
abstract: Mitochondria communicate with the rest of the cell through channels located in their inner and outer membranes. Most of the time, the message is encoded by the flow of anions and cations e.g., through VDAC and PTP, respectively. However, proteins are also both imported and exported across the mitochondrial membranes e.g., through TOM and MAC, respectively. Transport through mitochondrial channels is exquisitely regulated and controls a myriad of processes; from energy production to cell death. Here, we examine the role of some of the mitochondrial channels involved in neurodegeneration, ischemia-reperfusion injury and cancer in the context of their potential as therapeutic targets.
authors.affiliation: New York University, College of Dentistry, 345 East 24th Street, New York, NY 10010, United States.
authors.forename: Pablo M
authors.initials: PM
authors.lastname: Peixoto
authors.forename: Laurent M
authors.initials: LM
authors.lastname: Dejean
authors.forename: Kathleen W
authors.initials: KW
authors.lastname: Kinnally
mesh_terms: D000818:Animals; D004358:Drug Therapy / Q000379:methods; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism*; D009369:Neoplasms / Q000503:physiopathology*; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D015427:Reperfusion Injury / Q000503:physiopathology*
chemical_list: D007473:Ion Channels