title: Gomisin N has anti-allergic effect and inhibits inflammatory cytokine expression in mouse bone marrow-derived mast cells.
abstract: Gomisin N is a bioactive compound and a prominent anti-allergic agent found in the fruits of tree Schizandra chinensis. However, its effects on the bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanism remain unknown. In this study, the biological effects of gomisin were evaluated while focusing on its effects on the allergic mediator in PMA + A23187-stimulated BMMCs. The anti-allergic effect of gomisin has shown that inhibited PMA + A23187-induced interleukin-6 (IL-6) production. An investigation was also conducted to determine its effects on the production of several allergic mediators including prostaglandin D(2) (PGD(2)), leukotriene C(4) (LTC(4)), β-hexosaminidase (β-Hex), and cyclooxygenase-2 (COX-2) protein. The results revealed that gomisin inhibited the PMA + A23187-induced production of IL-6, PGD(2), LTC(4), β-Hex, and COX-2 protein. Taken together, these findings indicate that gomisin N has the potential for use in the treatment of allergy.
authors.affiliation: College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk, Republic of Korea Republic of Korea.
authors.forename: Hee-Sung
authors.initials: HS
authors.lastname: Chae
authors.forename: Ok-Hwa
authors.initials: OH
authors.lastname: Kang
authors.forename: You-Chang
authors.initials: YC
authors.lastname: Oh
authors.forename: Jang-Gi
authors.initials: JG
authors.lastname: Choi
authors.forename: Joon-Ho
authors.initials: JH
authors.lastname: Keum
authors.forename: Sung-Bae
authors.initials: SB
authors.lastname: Kim
authors.forename: Yong-Sik
authors.initials: YS
authors.lastname: Kim
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Mun
authors.forename: Dong-Won
authors.initials: DW
authors.lastname: Shin
authors.forename: Sin-Hee
authors.initials: SH
authors.lastname: Han
authors.forename: Dong-Yeul
authors.initials: DY
authors.lastname: Kwon
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D000001:Calcimycin / Q000494:pharmacology; D061207:Calcium Ionophores / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology; D002478:Cells, Cultured; D034242:Cyclooctanes / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000276:immunology; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000096:biosynthesis / Q000276:immunology*; D017705:Lignans / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D011083:Polycyclic Compounds / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate
chemical_list: D018926:Anti-Allergic Agents; D061207:Calcium Ionophores; D002273:Carcinogens; D034242:Cyclooctanes; D018836:Inflammation Mediators; D015850:Interleukin-6; D017705:Lignans; D011083:Polycyclic Compounds; C015499:schizandrin B; D000001:Calcimycin; D013755:Tetradecanoylphorbol Acetate