title: Synthesis of oligopeptides through O-acyl isopeptide method.
abstract: The O-acyl isopeptide method has recently gained attention as an efficient protocol for the synthesis of 'difficult sequence' peptides. Herein, synthesis of three oligopeptides of different length, a pentapeptide Gly-Leu-Leu-Ser-Val, a heptapeptide fragment 285-291 of transmembrane (M7-24-T40) Ala-Val-Leu-Ser-Leu-Pro-Leu and a decapeptide, Gly-Leu-Leu-Ser-Val-Leu-Gly-Ser-Val-Ala were demonstrated in solution phase by employing O-acyl isopeptide method. The peptides were established through an efficient pH triggered intramolecular O→N acyl migration under physiological conditions. The reactions were clean and complete in appreciable length of time.
authors.affiliation: Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore, India.
authors.forename: H S
authors.initials: HS
authors.lastname: Lalithamba
authors.forename: H P
authors.initials: HP
authors.lastname: Hemantha
authors.forename: Vommina V
authors.initials: VV
authors.lastname: Sureshbabu
mesh_terms: D000595:Amino Acid Sequence; D001709:Biotechnology / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D057930:Click Chemistry / Q000379:methods*; D005449:Fluorenes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D009842:Oligopeptides / Q000138:chemical synthesis*
chemical_list: D005449:Fluorenes; D009842:Oligopeptides