title: [The role of extracellular ATP in the airway].
abstract: ATP serves not only as an energy source for all cell types but as an extracellular messenger for autocrine and paracrine signaling involving in a versatile role in modulating various cellular functions. This review summarizes the efflux pathways of ATP released from airway epithelial cells, the signal pathways through which ATP induces ion transport by the epithelia of airway, as well as its epithelium-dependent modulation of smooth muscle contraction of airway and the mechanism underlying in airway diseases.
authors.affiliation: School of Life Science, SUN Yat-sen University, Guangzhou 510275, China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Guo
authors.forename: Yu-Li
authors.initials: YL
authors.lastname: Luo
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Zhou
mesh_terms: D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D004847:Epithelial Cells / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D017136:Ion Transport / Q000502:physiology*; D009079:Mucociliary Clearance / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology; D011654:Pulmonary Edema / Q000503:physiopathology; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000166:cytology / Q000378:metabolism*
chemical_list: D000255:Adenosine Triphosphate