title: [An analysis of hyperinsulinemia in Bartter syndrome].
abstract: OBJECTIVE
  To analyse hyperinsulinemia in Bartter syndrome.
  
  
  METHODS
  Twenty-three cases of Bartter syndrome [age (27 ± 9) years; fasting serum potassium (2.8 ± 0.5) mmol/L], 20 patients of aldosterone-producing adenoma [APA, age (45 ± 11)years, fasting serum potassium (3.0 ± 0.4) mmol/L], 20 patients of idiopathic hyperaldosteronism [IHA, age (51 ± 11) years, fasting serum potassium (3.4 ± 0.2) mmol/L] were diagnosed in Peking Union Medical College Hospital from September 2003 to May 2008. All patients underwent 3-hours oral glucose tolerance test (3hOGTT), postural stimulation test and calculated HOMA-insulin resistance (HOMA-IR) and HOMA-insulin sensitivity (HOMA-IS) by Homeostasis model.
  
  
  RESULTS
  The insulin area under curve[(229.0 ± 162.4) mIU×L(-1)×h] was significantly higher than APA group [(121.2 ± 81.1) mIU×L(-1)×h, P < 0.05] and were similar to the aged-matched patients with IHA [(227.7 ± 158.6) mIU×L(-1)×h]. But HOMA-IR in Bartter group were similar to APA group (1.96 ± 1.14 vs 1.41 ± 0.91), and HOMA-IR in APA group was lower than IHA group (1.96 ± 1.14 vs 2.40 ± 1.60, P < 0.05). There was no deference in HOMA-IS among three groups, but APA group had lower level. In all three groups, the peak of insulin secretion was delayed.
  
  
  CONCLUSIONS
  Bartter syndrome patients commonly present with hyperinsulinemia.
authors.affiliation: Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
authors.forename: Zheng-Pei
authors.initials: ZP
authors.lastname: Zeng
authors.forename: An-Li
authors.initials: AL
authors.lastname: Tong
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Song
authors.forename: Wei
authors.initials: W
authors.lastname: Liang
authors.forename: Yong
authors.initials: Y
authors.lastname: Fu
authors.forename: Wei-Bo
authors.initials: WB
authors.lastname: Xia
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Jiang-Feng
authors.initials: JF
authors.lastname: Mao
authors.forename: Hua-Bing
authors.initials: HB
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D001477:Bartter Syndrome / Q000097:blood*; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008875:Middle Aged; D055815:Young Adult
chemical_list: D007328:Insulin