title: Characterisation of the essential oil of Nepeta glomerata Montbret et Aucher ex Bentham from Lebanon and its biological activities.
abstract: The essential oil of Nepeta glomerata from Lebanon was studied by means of GC and GC/MS analysis; 70 compounds were identified. The oil was constituted mainly by monoterpenes and the most abundant components were α-pinene, spathulenol and carvacrol. Nepeta glomerata oil showed antibacterial activity, particularly towards Gram-positive bacteria, and also inhibited LPS-induced NO production in macrophage cell line RAW 264.7, with an IC(50) value of 78.1 µg mL(-1). Furthermore, an in vitro cytotoxic assay showed that the oil was more active on a renal adenocarcinoma cell line (48% of inhibition of proliferation at 100 µg mL(-1)) in comparison to an amelanotic melanoma.
authors.affiliation: Department of Chemistry of Natural Compounds, University of Naples Federico II, via D. Montesano, 49, I-80131 Naples, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Rigano
authors.forename: Nelly Apostolides
authors.initials: NA
authors.lastname: Arnold
authors.forename: Filomena
authors.initials: F
authors.lastname: Conforti
authors.forename: Federica
authors.initials: F
authors.lastname: Menichini
authors.forename: Carmen
authors.initials: C
authors.lastname: Formisano
authors.forename: Franco
authors.initials: F
authors.lastname: Piozzi
authors.forename: Felice
authors.initials: F
authors.lastname: Senatore
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007861:Lebanon; D008070:Lipopolysaccharides; D051379:Mice; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000032:analysis; D027521:Nepeta / Q000737:chemistry*; D009569:Nitric Oxide / Q000032:analysis; D009822:Oils, Volatile / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D008070:Lipopolysaccharides; D039821:Monoterpenes; D009822:Oils, Volatile; D009569:Nitric Oxide