title: pH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization.
abstract: Representing a new category of polymer-drug conjugates, brush polymer-drug conjugates were prepared by ring-opening metathesis copolymerization. Following judicious structural design, these conjugates exhibited well-shielded drug moieties, significant water solubility, well-defined nanostructures, and acid-triggered drug release.
authors.affiliation: Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
authors.forename: Jiong
authors.initials: J
authors.lastname: Zou
authors.forename: Goran
authors.initials: G
authors.lastname: Jafr
authors.forename: Efrosyni
authors.initials: E
authors.lastname: Themistou
authors.forename: Yoonsing
authors.initials: Y
authors.lastname: Yap
authors.forename: Zachary A P
authors.initials: ZA
authors.lastname: Wintrob
authors.forename: Paschalis
authors.initials: P
authors.lastname: Alexandridis
authors.forename: Alice C
authors.initials: AC
authors.lastname: Ceacareanu
authors.forename: Chong
authors.initials: C
authors.lastname: Cheng
mesh_terms: D006863:Hydrogen-Ion Concentration; D058726:Nanoconjugates / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*
chemical_list: D058726:Nanoconjugates; D004364:Pharmaceutical Preparations; D011108:Polymers