title: Transfer of KPC-2 Carbapenemase from Klebsiella pneumoniae to Escherichia coli in a patient: first case in Europe.
abstract: The first case in Europe of Klebsiella pneumoniae carbapenemase (KPC) 2 transfer from K. pneumoniae to Escherichia coli in the same patient is described. KPC-positive plasmids from the two species were identical, indicating horizontal plasmid transfer. Selection of the KPC-producing E. coli strain was triggered by therapy with meropenem.
authors.affiliation: Department of Histology, University of Padua, Via Gabelli 63, 35121 Padua, Italy. sara.richter@unipd.it
authors.forename: Sara N
authors.initials: SN
authors.lastname: Richter
authors.forename: Ilaria
authors.initials: I
authors.lastname: Frasson
authors.forename: Cristina
authors.initials: C
authors.lastname: Bergo
authors.forename: Saverio
authors.initials: S
authors.lastname: Parisi
authors.forename: Antonietta
authors.initials: A
authors.lastname: Cavallaro
authors.forename: Giorgio
authors.initials: G
authors.lastname: Palù
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics*; D005060:Europe; D022761:Gene Transfer, Horizontal; D006801:Humans; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000235:genetics; D008297:Male; D000077731:Meropenem; D008875:Middle Aged; D010957:Plasmids / Q000032:analysis; D012641:Selection, Genetic; D013845:Thienamycins / Q000627:therapeutic use; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases; D000077731:Meropenem