title: Mechanical behavior of the erythrocyte in microvessel stenosis.
abstract: The passage of red blood cells (RBCs) through capillaries is essential for human blood microcirculation. This study used a moving mesh technology that incorporated leader-follower pairs to simulate the fluid-structure and structure-structure interactions between the RBC and a microvessel stenosis. The numerical model consisted of plasma, cytoplasm, the erythrocyte membrane, and the microvessel stenosis. Computational results showed that the rheology of the RBC is affected by the Reynolds number of the plasma flow as well as the surface-to-volume ratio of the erythrocyte. At a constant inlet flow rate, an increased plasma viscosity will improve the transit of the RBC through the microvessel stenosis. For the above reasons, we consider that the decreased hemorheology in microvessels in a pathological state may primarily be attributed to an increase in the number of white blood cells. This leads to the aggregation of RBCs and a change in the blood flow structure. The present fundamental study of hemorheology aimed at providing theoretical guidelines for clinical hemorheology.
authors.affiliation: State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian, 116024, China.
authors.forename: ZhiGuo
authors.initials: Z
authors.lastname: Zhang
authors.forename: XiWen
authors.initials: X
authors.lastname: Zhang
mesh_terms: D001809:Blood Viscosity; D002462:Cell Membrane / Q000378:metabolism; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D003251:Constriction, Pathologic; D003593:Cytoplasm / Q000378:metabolism; D004903:Erythrocyte Aggregation; D004912:Erythrocytes / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000166:cytology; D008833:Microcirculation; D055806:Microvessels / Q000473:pathology*; D012212:Rheology / Q000379:methods; D013997:Time Factors; D014783:Viscosity