title: Single photon emission computed tomography/positron emission tomography imaging and targeted radionuclide therapy of melanoma: new multimodal fluorinated and iodinated radiotracers.
abstract: This study reports a series of 14 new iodinated and fluorinated compounds offering both early imaging ((123)I, (124)I, (18)F) and systemic treatment ((131)I) of melanoma potentialities. The biodistribution of each (125)I-labeled tracer was evaluated in a model of melanoma B16F0-bearing mice, using in vivo serial γ scintigraphic imaging. Among this series, [(125)I]56 emerged as the most promising compound in terms of specific tumoral uptake and in vivo kinetic profile. To validate our multimodality concept, the radiosynthesis of [(18)F]56 was then optimized and this radiotracer has been successfully investigated for in vivo PET imaging of melanoma in B16F0- and B16F10-bearing mouse model. The therapeutic efficacy of [(131)I]56 was then evaluated in mice bearing subcutaneous B16F0 melanoma, and a significant slow down in tumoral growth was demonstrated. These data support further development of 56 for PET imaging ((18)F, (124)I) and targeted radionuclide therapy ((131)I) of melanoma using a single chemical structure.
authors.affiliation: Clermont Université, Université d'Auvergne, Imagerie Moléculaire et Thérapie Vectorisée, Clermont-Ferrand, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Maisonial
authors.forename: Bertrand
authors.initials: B
authors.lastname: Kuhnast
authors.forename: Janine
authors.initials: J
authors.lastname: Papon
authors.forename: Raphaël
authors.initials: R
authors.lastname: Boisgard
authors.forename: Martine
authors.initials: M
authors.lastname: Bayle
authors.forename: Aurélien
authors.initials: A
authors.lastname: Vidal
authors.forename: Philippe
authors.initials: P
authors.lastname: Auzeloux
authors.forename: Latifa
authors.initials: L
authors.lastname: Rbah
authors.forename: Mathilde
authors.initials: M
authors.lastname: Bonnet-Duquennoy
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Miot-Noirault
authors.forename: Marie-Josèphe
authors.initials: MJ
authors.lastname: Galmier
authors.forename: Michèle
authors.initials: M
authors.lastname: Borel
authors.forename: Serge
authors.initials: S
authors.lastname: Askienazy
authors.forename: Frédéric
authors.initials: F
authors.lastname: Dollé
authors.forename: Bertrand
authors.initials: B
authors.lastname: Tavitian
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Madelmont
authors.forename: Nicole
authors.initials: N
authors.lastname: Moins
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Chezal
mesh_terms: D000818:Animals; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D051379:Mice; D049268:Positron-Emission Tomography; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005462:Fluorine Radioisotopes; D007457:Iodine Radioisotopes