title: Conservancy of the α4β7 integrin mimotope in the V2 domain of HIV type 1 CRF07_BC compared to subtype B' strains in China.
abstract: HIV-1 is capable of mimicking the ligand of integrin α(4)β(7) by displaying a tripeptide mimotope on the V2 region. Through this mimicry HIV can bind the α(4)β(7) integrin and get carried through the lymphocyte proliferation signaling pathway, cell-to-cell adhesion and can migrate to gut-associated lymphoid tissues. The same tripeptide motif was suggested to be the epicenter of neutralization in laboratory strains of HIV-1. In this study, we compared the α(4)β(7) binding sites of two HIV-1 subtypes prevalent in China and found that the tripeptide binding domain of α(4)β(7) was more diverse in subtype B' strains than in CRF07_BC.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.forename: John L
authors.initials: JL
authors.lastname: Mokili
authors.forename: Kunxue
authors.initials: K
authors.lastname: Hong
authors.forename: Jianping
authors.initials: J
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Wei
authors.forename: Ruolei
authors.initials: R
authors.lastname: Xin
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Song
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Mingming
authors.initials: M
authors.lastname: Jia
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D002681:China / Q000453:epidemiology; D019143:Evolution, Molecular; D015699:HIV Envelope Protein gp120 / Q000378:metabolism*; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D010802:Phylogeny; D011487:Protein Conformation; D012367:RNA, Viral / Q000097:blood* / Q000235:genetics; D015398:Signal Transduction; D053585:Virus Attachment
chemical_list: D015699:HIV Envelope Protein gp120; D016023:Integrins; D012367:RNA, Viral; C514793:gp120 protein, Human immunodeficiency virus 1; C071777:integrin alpha4beta7