title: Linking X chromosome inactivation to pluripotency: Necessity or fate?
abstract: Silencing one X chromosome is essential for the development of female mammals, but the regulation of this process appears to vary between species. In the mouse, which has thus far been the leading model system in the field, X chromosome inactivation (XCI) is tightly coupled to pluripotency and the underlying mechanisms have just begun to be deciphered. However, mechanistic aspects of XCI regulation in other species have yet to be thoroughly investigated. Here we review current knowledge of the developmental regulation of XCI in mice and humans and discuss the extent to which the intimate link between XCI and pluripotency extends beyond rodents.
authors.affiliation: UMR7216 Epigenetics and Cell Fate, CNRS/Université Paris Diderot, 35 rue Hélène Brion, 75013 Paris, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Makhlouf
authors.forename: Claire
authors.initials: C
authors.lastname: Rougeulle
mesh_terms: D000818:Animals; D054278:Embryonal Carcinoma Stem Cells / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism*; D051379:Mice; D023421:Models, Animal; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000235:genetics*; D014960:X Chromosome / Q000235:genetics; D049951:X Chromosome Inactivation / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C465658:Tsix transcript, mouse; C077885:XIST non-coding RNA