title: Enzyme-catalyzed synthesis of a novel thermosensitive polyester with pendant ketoprofen.
abstract: A novel thermosensitive polyester with pendant ketoprofen was synthesized by copolymerization of PEG 800 with 2-ketoprofendimethylmalate using CAL-B at 70 °C. The products were characterized by NMR spectra and GPC. The in vitro study demonstrated that the polyester could release ketoprofen in physiological conditions, which indicates that the polyester could be a promising prodrug.
authors.affiliation: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Wang
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhou
authors.forename: Zao
authors.initials: Z
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Li
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Yu
mesh_terms: D002175:Candida / Q000201:enzymology; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis*; D006801:Humans; D006868:Hydrolysis; D007660:Ketoprofen / Q000737:chemistry*; D008049:Lipase / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis*; D011092:Polyethylene Glycols / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis*; D044366:Transition Temperature
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011355:Prodrugs; D011092:Polyethylene Glycols; D007660:Ketoprofen; D008049:Lipase