title: In vitro activities of anidulafungin and other antifungal agents against biofilms formed by clinical isolates of different Candida and Aspergillus species.
abstract: We tested the activities of anidulafungin and other antifungal agents against clinical isolates of different fungal species. For Candida species, high sessile MIC₉₀s (SMIC₉₀s) were obtained for fluconazole, voriconazole, and amphotericin B, whereas the anidulafungin SMIC₉₀s were very low, as were those for caspofungin. Comparatively, for Aspergillus species, higher SMIC₉₀ values were obtained not only for amphotericin B and voriconazole but also for the echinocandins.
authors.affiliation: Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Fiori
authors.forename: Brunella
authors.initials: B
authors.lastname: Posteraro
authors.forename: Riccardo
authors.initials: R
authors.lastname: Torelli
authors.forename: Mario
authors.initials: M
authors.lastname: Tumbarello
authors.forename: David S
authors.initials: DS
authors.lastname: Perlin
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fadda
authors.forename: Maurizio
authors.initials: M
authors.lastname: Sanguinetti
mesh_terms: D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects* / Q000502:physiology; D018441:Biofilms / Q000187:drug effects*; D002175:Candida / Q000187:drug effects* / Q000502:physiology; D000077336:Caspofungin; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077612:Anidulafungin; D000077336:Caspofungin