title: Decrease in reduced-form albumin among chronic kidney disease patients: new insights in cardiovascular complications.
abstract: From the perspective of free cysteine residue (Cys-34), human serum albumin (HSA) comprises a mixture of human mercaptoalbumin (HMA), in which the Cys-34 is not oxidized, human non-mercaptoalbumin (HNA)-1, which has a disulfide bond that can be reversibly oxidized, mainly by cysteine, and HNA-2, which is strongly oxidized to form sulfinic (-SO(2) H) or sulfonic (-SO(3) H) species. We have developed a convenient high-performance liquid chromatographic (HPLC) system for the clear separation of HSA into HMA, HNA-1 and HNA-2, and we have studied the dynamic changes of HSA-redox under various states of chronic kidney disease, in both a clinical and an experimental setting. In this article, we discuss the relationship between HSA-redox (especially the decrease of the reduced form), dialyzable uremic toxins and incident cardiovascular disease based on our recent investigations.
authors.affiliation: Division of Kidney and Hypertension, The Jikei University School of Medicine, Tokyo, Japan. terawaki@jikei.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Terawaki
authors.forename: Seiichi
authors.initials: S
authors.lastname: Era
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakayama
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Hosoya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002908:Chronic Disease; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis / Q000378:metabolism*; D000075462:Serum Albumin, Human
chemical_list: D012709:Serum Albumin; C001702:mercaptoalbumin; C079732:nonmercaptalbumin; D000075462:Serum Albumin, Human