title: Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis.
abstract: OBJECTIVE
  Hepatocellular carcinoma occurs frequently in cirrhosis related to hepatitis C virus (type C cirrhosis), and preventative treatment with interferon is costly and likely to cause adverse reactions. Menatetrenone, a vitamin K2 preparation, has recently been reported to inhibit the posttreatment relapse of hepatocellular carcinoma. We therefore examined whether menatetrenone could prevent the development of hepatocellular carcinoma in patients with type C cirrhosis.
  
  
  METHODS
  This prospective, randomized trial recruited patients with type C cirrhosis, platelet count of 10 x 10(4) microl or less, and no history of hepatocellular carcinoma. Patients were assigned to a menatetrenone group (n = 22, 4 5mg of menatetrenone daily, orally) or a control group (n = 18). Follow-up with image diagnosis was performed every 3-6 months.
  
  
  RESULTS
  No adverse events of menatetrenone treatment were observed. Hepatocellular carcinoma occurred in 2 of 22 patients in the menatetrenone group (9.1%) and 5 of 18 patients in the control group (27.8%); however, this difference did not reach statistical significance.
  
  
  CONCLUSIONS
  The present findings suggest that menatetrenone has some inhibitory effect on development of hepatocellular carcinoma in patients with type C cirrhosis. Consequently, to further validate its benefits, we believe that menatetrenone should be actively administered to patients with intractable (interferon-resistant) cirrhosis.
authors.affiliation: Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan. kzkojimajp@yahoo.co.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kojima
authors.forename: Masaya
authors.initials: M
authors.lastname: Tamano
authors.forename: Takashi
authors.initials: T
authors.lastname: Akima
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Toru
authors.initials: T
authors.lastname: Kuniyoshi
authors.forename: Chizu
authors.initials: C
authors.lastname: Maeda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Majima
authors.forename: Koji
authors.initials: K
authors.lastname: Kusano
authors.forename: Toshimitu
authors.initials: T
authors.lastname: Murohisa
authors.forename: Makoto
authors.initials: M
authors.lastname: Iijima
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hiraishi
mesh_terms: D000368:Aged; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D024482:Vitamin K 2 / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D016588:Anticarcinogenic Agents; D024482:Vitamin K 2; C030814:menatetrenone