title: Siblings presenting with progressive congenital aleukemic leukemia cutis.
abstract: Congenital leukemia is infrequent, occurring in <1% of pediatric leukemia patients, and mainly of myeloid lineage. Twenty-five to 30% of congenital leukemia cases present with cutaneous leukemic infiltrates. Rarely, infants will have aleukemic leukemia cutis, presenting with leukemic skin lesions but without systemic symptoms or bone marrow involvement. Few cases of congenital aleukemic leukemia cutis have been reported in the literature. The course of disease is variable as cases of spontaneous resolution have been described. Here we present the first report of siblings with progressive congenital aleukemic leukemia cutis, both treated successfully with myeloid leukemia chemotherapy.
authors.affiliation: Children's Hospital and Research Center Oakland, Oakland, California 94609, USA. aagrawal@mail.cho.org
authors.forename: Anurag K
authors.initials: AK
authors.lastname: Agrawal
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
authors.forename: Carla
authors.initials: C
authors.lastname: Golden
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D003561:Cytarabine / Q000009:adverse effects / Q000627:therapeutic use; D003630:Daunorubicin / Q000009:adverse effects / Q000627:therapeutic use; D003907:Dexamethasone / Q000009:adverse effects / Q000627:therapeutic use; D005047:Etoposide / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D035781:Siblings; D012878:Skin Neoplasms / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology; D013866:Thioguanine / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D003561:Cytarabine; D005047:Etoposide; D003907:Dexamethasone; D013866:Thioguanine; D003630:Daunorubicin