title: Use of platelet-rich plasma and hyaluronic acid in the loss of substance with bone exposure.
abstract: OBJECTIVE
  : In lower-extremity surgery, the complex wound with bone exposure remains a challenging problem for the plastic surgeon. The purpose of this study was to describe a new therapeutic approach to stimulate the regeneration of the lower-extremity complex wounds based on a combined treatment composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) dressing.
  
  
  METHODS
  : Wounds with posttraumatic bone exposure have been treated with HA dressing alone or in combination with PRP.
  
  
  METHODS
  : Fifteen patients affected by lower-extremity wound with posttraumatic bone exposure have been treated at the Department of Plastic and Reconstructive Surgery, University of Tor Vergata, Rome, Italy.
  
  
  RESULTS
  : After a single treatment, the authors observed that the mean re-epithelialization time was 8.1 weeks in 73.3% patients treated with PRP and HA dressing versus the 30% patients treated with HA dressing only.
  
  
  CONCLUSIONS
  : These data confirm the evidence of using PRP technology in the healing of both soft- and hard-tissue wounds. Moreover, the satisfaction of the patient confirms the quality of this study's results.
authors.affiliation: Department of Plastic and Reconstructive Surgery, University of Tor Vergata, Rome, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Cervelli
authors.forename: Lucilla
authors.initials: L
authors.lastname: Lucarini
authors.forename: Diana
authors.initials: D
authors.lastname: Spallone
authors.forename: Ludovico
authors.initials: L
authors.lastname: Palla
authors.forename: Gianfranco Marcello
authors.initials: GM
authors.lastname: Colicchia
authors.forename: Pietro
authors.initials: P
authors.lastname: Gentile
authors.forename: Barbara
authors.initials: B
authors.lastname: De Angelis
mesh_terms: D001458:Bandages; D001792:Blood Platelets; D001842:Bone and Bones; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D007866:Leg / Q000601:surgery; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D013223:Statistics as Topic; D013518:Surgery, Plastic / Q000379:methods; D055675:Viscosupplements / Q000627:therapeutic use*; D014945:Wound Healing; D014947:Wounds and Injuries / Q000601:surgery*
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid