title: Regional ganglionated plexus ablation eliminated rapid firing in an electrically isolated pulmonary vein.
abstract: Atrial fibrillation (AF) was initiated by rapid firing from left superior pulmonary vein (PV) by administration of isoproterenol (ISP) and adenosine triphosphate (ATP) before ablation. After successful isolation of all PVs, ISP and ATP were administered again. PVs were still isolated but an episode of rapid firing was observed inside the left PV isolation line during sinus rhythm. Radiofrequency energy was then delivered to the areas of superior left ganglionated plexus (GP) and inferior left GP. Then, PV firing could no longer be initiated. It suggests additional GP ablation may have additional benefit to circumferential PV isolation, to reduce the incidence of AF recurrence.
authors.affiliation: Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.
authors.forename: Ru-Hong
authors.initials: RH
authors.lastname: Jiang
authors.forename: Chen-Yang
authors.initials: CY
authors.lastname: Jiang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Sunny S
authors.initials: SS
authors.lastname: Po
mesh_terms: D001281:Atrial Fibrillation / Q000517:prevention & control* / Q000601:surgery*; D017115:Catheter Ablation; D005725:Ganglia, Autonomic / Q000601:surgery*; D015171:Ganglionectomy / Q000379:methods*; D006329:Heart Conduction System / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011667:Pulmonary Veins / Q000601:surgery*; D012086:Reoperation; D055502:Secondary Prevention; D016896:Treatment Outcome