title: Inositol phosphoglycan P-type in infants of preeclamptic mothers.
abstract: BACKGROUND
  Inositol phosphoglycan P-type (P-IPG) has consistently found to be elevated during active preeclampsia, although the biosynthetic source has to be identified yet. This multicenter prospective cross-sectional case-control study evaluated the fetus/newborn as the source of P-IPG.
  
  
  METHODS
  A urine specimen was collected longitudinally for three consecutive days after delivery from 90 newborns and their mothers, and ordered according to clinical diagnosis of preeclampsia, gestational hypertension, or healthy pregnancy.
  
  
  RESULTS
  The urinary excretion of P-IPG on day 0 was higher in the mothers in all groups (p < 0.05) with higher levels in preeclamptic women (p < 0.01) in the mothers compared to their newborns in the preeclamptic group (p<0.01). The difference persisted at least two days post partum.
  
  
  CONCLUSIONS
  Findings of this study confirm the specificity of the increase in urinary excretion of P-IPG in preeclamptic mothers at day of birth compared to healthy pregnancy and GH, but does not extend to their newborns.
authors.affiliation: Department of Obstetrics and Gynaecology, Sacro Cuore Don Calabria, Verona, Negrar, Italy. marcoscioscia@gmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Scioscia
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Robillard
authors.forename: David R
authors.initials: DR
authors.lastname: Hall
authors.forename: Laurens H
authors.initials: LH
authors.lastname: Rademacher
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Williams
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Rademacher
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000652:urine*; D007295:Inositol Phosphates / Q000652:urine*; D011134:Polysaccharides / Q000652:urine*; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D007295:Inositol Phosphates; D011134:Polysaccharides; C028039:inositol phosphate glycan