title: Leishmanicidal and cytotoxic activities of extracts and naturally-occurring compounds from two Lauraceae species.
abstract: The in vitro leishmanicidal effects of ethanolic extracts and fifteen naturally-occurring compounds (five lignans, eight neolignans, a diterpene and a dihydrochalcone), obtained from Pleurothyrium cinereum and Ocotea macrophylla, were evaluated on promastigotes of Leishmania panamensis and L. braziliensis. In addition, in order to determine the selective action on Leishmania species as a safety principle, in vitro cytotoxicity on J774 cells was also evaluated for test compounds and extracts. One extract and seven compounds showed activity against Leishmania parasites at different levels. Dihydroflavokawin B (8) was found to be the most potent antileishmanial compound on both parasites, whilst (+)-otobaphenol (14), was found to be the most selective compound on L. panamensis.
authors.affiliation: Grupo de Investigación en Inmunotoxicología, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, 57+1+3165120 Bogotá, Colombia.
authors.forename: Jeysson
authors.initials: J
authors.lastname: Sánchez-Suárez
authors.forename: Ericsson
authors.initials: E
authors.lastname: Coy-Barrera
authors.forename: Luis Enrique
authors.initials: LE
authors.lastname: Cuca
authors.forename: Gabriela
authors.initials: G
authors.lastname: Delgado
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002460:Cell Line; D019770:Lauraceae / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D007892:Leishmania braziliensis / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts