title: Strengthening the reporting of genetic risk prediction  studies (GRIPS): explanation and elaboration.
abstract: The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but they vary widely in completeness of reporting and apparent quality. Transparent reporting of the strengths and weaknesses of these studies is important to facilitate the accumulation of evidence on genetic risk prediction. A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by previous reporting guidelines. These recommendations aim to enhance the transparency, quality and completeness of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct or analysis.
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. a.janssens@erasmusmc.nl
authors.forename: A Cecile J W
authors.initials: AC
authors.lastname: Janssens
authors.forename: John P A
authors.initials: JP
authors.lastname: Ioannidis
authors.forename: Sara
authors.initials: S
authors.lastname: Bedrosian
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Siobhan M
authors.initials: SM
authors.lastname: Dolan
authors.forename: Nicole
authors.initials: N
authors.lastname: Dowling
authors.forename: Isabel
authors.initials: I
authors.lastname: Fortier
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Freedman
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Grimshaw
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Gulcher
authors.forename: Marta
authors.initials: M
authors.lastname: Gwinn
authors.forename: Mark A
authors.initials: MA
authors.lastname: Hlatky
authors.forename: Holly
authors.initials: H
authors.lastname: Janes
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.forename: Stephanie
authors.initials: S
authors.lastname: Melillo
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: O'Donnell
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pencina
authors.forename: David
authors.initials: D
authors.lastname: Ransohoff
authors.forename: Sheri D
authors.initials: SD
authors.lastname: Schully
authors.forename: Daniela
authors.initials: D
authors.lastname: Seminara
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Winn
authors.forename: Caroline F
authors.initials: CF
authors.lastname: Wright
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: Julian
authors.initials: J
authors.lastname: Little
authors.forename: Muin J
authors.initials: MJ
authors.lastname: Khoury
mesh_terms: D055106:Genome-Wide Association Study; D023281:Genomics / Q000379:methods*; D006801:Humans; D008957:Models, Genetic; D016032:Randomized Controlled Trials as Topic