title: An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations.
abstract: Graves' disease (GD) is a common autoimmune disorder with a genetic predisposition. The cytokine interleukin-10 (IL-10) has a central role in mediating inflammation, which may affect the outcome of the patients with GD. To elucidate the impact of IL-10 gene polymorphisms, we performed a two-stage case-control association study of five single-nucleotide polymorphisms (SNPs) within the IL-10 gene as well as a meta-analysis of two SNP's rs1800896 and rs1800872 covering three previous studies from Iran, Taiwan, and the United Kingdom. The five SNPs were genotyped by SNPstream Genotyping and Taqman PCR. There was a significant increase of G allele of rs1800896 in the two cohorts (P (allele) = 2.6 × 10(-4) and 0.0082 for cohort Shanghai and Xiamen, respectively) compared with the controls. The meta-analysis showed the risk-increasing effects for the G allele of rs1800896 in GD (OR = 1.88; P < 0.00001). The allele and haplotype analysis results suggested that the polymorphisms of IL-10 were associated with GD susceptibility in the Chinese population.
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, 197 RuiJin Er Lu, Shanghai, 200025, People's Republic of China.
authors.forename: Nan
authors.initials: N
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Lu
authors.forename: Feng
authors.initials: F
authors.lastname: Tao
authors.forename: Ting
authors.initials: T
authors.lastname: Guo
authors.forename: Changqin
authors.initials: C
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Cui
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005838:Genotype; D006111:Graves Disease / Q000208:ethnology* / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D007492:Iran; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013624:Taiwan; D006113:United Kingdom; D055815:Young Adult
chemical_list: D016753:Interleukin-10