title: Pilomatrix carcinoma of the clitoris.
abstract: Pilomatrix carcinoma, a malignant counterpart of pilomatrixoma, is a rare skin neoplasm composed of basaloid and shadow cells that characterize differentiation toward the hair matrix. The authors present a case of pilomatrix carcinoma of the clitoris, a very unusual location not previously reported. Diagnostic criteria and differential diagnoses are discussed. Pilomatrix carcinoma should be differentiated from benign pilomatrixoma and other carcinomas with shadow cells, including basal cell carcinoma with matrical differentiation and metastases of visceral carcinomas with shadow cells.
authors.affiliation: Institute of Oncology, Ljubljana, Slovenia.
authors.forename: Barbara
authors.initials: B
authors.lastname: Gazic
authors.forename: Simona
authors.initials: S
authors.lastname: Sramek-Zatler
authors.forename: Alenka
authors.initials: A
authors.lastname: Repse-Fokter
authors.forename: Joze
authors.initials: J
authors.lastname: Pizem
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000175:diagnosis; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology; D002987:Clitoris / Q000473:pathology*; D019938:Cyclin D1 / Q000378:metabolism; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006201:Hair Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D018296:Pilomatrixoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D051176:beta Catenin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C530104:CCND1 protein, human; C495270:CTNNB1 protein, human; D051176:beta Catenin; D019938:Cyclin D1