title: Genomic and phylogenetic characterization of Leanyer virus, a novel orthobunyavirus isolated in northern Australia.
abstract: Leanyer virus (LEAV), currently classified as a member of the genus Orthobunyavirus, in the family Bunyaviridae, was originally isolated from a pool of Anopheles meraukensis mosquitoes, collected at Leanyer, Northern Territory, Australia in 1974. When it failed to react in serological tests with antisera from other known viruses, full-length genomic sequencing was pursued to determine the relationship of LEAV to other orthobunyavirus species. Genetic and serological characterization confirmed its antigenic distance from other orthobunyaviruses, including to its closest genetic neighbours, the Simbu group viruses, suggesting that it may represent a new antigenic complex.
authors.affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Nazir
authors.initials: N
authors.lastname: Savji
authors.affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Palacios
authors.affiliation: Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Amelia
authors.initials: A
authors.lastname: Travassos da Rosa
authors.affiliation: 454 Life Sciences, Branford, CT, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Hutchison
authors.affiliation: 454 Life Sciences, Branford, CT, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Celone
authors.affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Hui
authors.affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Briese
authors.affiliation: Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
authors.forename: Charles H
authors.initials: CH
authors.lastname: Calisher
authors.affiliation: Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Tesh
authors.affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors.forename: W Ian
authors.initials: WI
authors.lastname: Lipkin
mesh_terms: D000818:Animals; D000852:Anopheles / Q000821:virology*; D001315:Australia; D016679:Genome, Viral; D023281:Genomics; D008969:Molecular Sequence Data; D016851:Orthobunyavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny