title: Fatal cerebral phaeohyphomycosis in an immunocompetent individual due to Thielavia subthermophila.
abstract: We report the first case of fatal brain infection in an Indian farmer caused by Thielavia subthermophila, a dematiaceous thermophilic fungus in the order Sordariales, and present a review of previous infections from this order. The patient failed amphotericin B therapy combined with surgical excision despite the drug's low MICs in vitro.
authors.affiliation: Department of Medical Mycology and Parasitology, School of Medicine/Molecular and Cell Biology Research Centre, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Badali
authors.forename: Jagdish
authors.initials: J
authors.lastname: Chander
authors.forename: Ashish
authors.initials: A
authors.lastname: Gupta
authors.forename: Hena
authors.initials: H
authors.lastname: Rani
authors.forename: Rajpal Singh
authors.initials: RS
authors.lastname: Punia
authors.forename: G Sybren
authors.initials: GS
authors.lastname: De Hoog
authors.forename: Jacques F
authors.initials: JF
authors.lastname: Meis
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology; D001921:Brain / Q000382:microbiology / Q000473:pathology*; D020314:Central Nervous System Fungal Infections / Q000150:complications / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003646:Debridement; D017809:Fatal Outcome; D006801:Humans; D007194:India; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D020037:Sordariales / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D000666:Amphotericin B