title: Identifying biomarkers as diagnostic tools in kidney transplantation.
abstract: There is a critical need for biomarkers for early diagnosis, treatment response, and surrogate end point and outcome prediction in organ transplantation, leading to a tailored and individualized treatment. Genomic and proteomic platforms have provided multiple promising new biomarkers during the last few years. However, there is still no routine application of any of these markers in clinical transplantation. This article will discuss the existing gap between biomarker discovery and clinical application in the kidney transplant setting. Approaches to implementing biomarker monitoring into clinical practice will also be discussed.
authors.affiliation: Molecular Transplant Research Laboratory, Transplant Division, Department of Surgery, Molecular Medicine Research Building, Virginia Commonwealth University, 1220 East Broad Street, Richmond, VA 23298, USA. vmas@mcvh-vcu.edu
authors.forename: Valeria R
authors.initials: VR
authors.lastname: Mas
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Mueller
authors.forename: Kellie J
authors.initials: KJ
authors.lastname: Archer
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Maluf
mesh_terms: D015415:Biomarkers; D055106:Genome-Wide Association Study; D006084:Graft Rejection / Q000175:diagnosis*; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D011379:Prognosis; D015427:Reperfusion Injury; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers