title: Diagnostic value of serum kallikrein-related peptidases 6 and 10 versus CA125 in ovarian cancer.
abstract: OBJECTIVE
  To assess the diagnostic value of serum KLK6 and KLK10 in patients with ovarian tumor in comparison to serum CA125.
  
  
  METHODS
  Based on clinical and sonographic findings, 90 patients were consecutively recruited at the Gynecological Oncology Unit, Ain Shams University Maternity Hospital. Preoperative serum KLK6 and/or KLK10 were determined by enzyme-linked immunosorbent assay technique. The patients' final diagnoses were those of the histopathological reports.
  
  
  RESULTS
  There were 27 malignant versus 63 benign cases. Serum markers' diagnostic specificity and sensitivity were 80.3/72.7, 56.8/64.0, and 39.53/58.3 for CA125, KLK6, and KLK10, respectively. Combination of CA125 with either of the other 2 markers revealed diagnostic enhancement with KLK10 (85.37/73.00) but not with KLK6 (42.86/86.36).
  
  
  CONCLUSIONS
  In ovarian cancer, serum KLK6 and KLK10 may have much lower overall sensitivities than serum CA125. However, whereas serum KLK6 may improve the sensitivity of CA125, serum KLK10 may have the highest specificity among the 3 markers.
authors.affiliation: Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. me_sherbini@yahoo.com
authors.forename: Mustafa Abdel Hafiz
authors.initials: MA
authors.lastname: El Sherbini
authors.forename: Maha Mohamed
authors.initials: MM
authors.lastname: Sallam
authors.forename: Emtiaz Abdel Kawy
authors.initials: EA
authors.lastname: Shaban
authors.forename: Amr Hassan
authors.initials: AH
authors.lastname: El-Shalakany
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018394:CA-125 Antigen / Q000032:analysis / Q000097:blood*; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000032:analysis / Q000097:blood*; D008565:Membrane Proteins / Q000032:analysis / Q000097:blood*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D055815:Young Adult
chemical_list: D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins; C100936:KLK10 protein, human; C103551:KLK6 protein, human; D007610:Kallikreins