title: Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters?
abstract: Families of oxysterol-binding protein (ORP) homologues are present in eukaryotes from yeast to man. Their hallmark feature is a characteristic ligand binding domain that, for several family members, has been shown to accommodate different oxysterols and/or cholesterol. ORPs of the "long" subtype contain targeting determinants for the endoplasmic reticulum and to other organelle membranes, the most prominent of which are phosphoinositide-binding pleckstrin homology domains, while "short" ORPs comprise a ligand binding domain with little additional sequences. There is increasing evidence that both long and short ORPs can be enriched at membrane contact sites, junctions of the endoplasmic reticulum with other organelles, where they are suggested to execute regulatory or sterol transfer functions. In this review we discuss the current evidence for putative roles of ORPs as sterol sensors or transporters.
authors.affiliation: Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki, Finland.
authors.forename: Terhi
authors.initials: T
authors.lastname: Vihervaara
authors.forename: Maurice
authors.initials: M
authors.lastname: Jansen
authors.forename: Riikka-Liisa
authors.initials: RL
authors.lastname: Uronen
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ohsaki
authors.forename: Elina
authors.initials: E
authors.lastname: Ikonen
authors.forename: Vesa M
authors.initials: VM
authors.lastname: Olkkonen
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism*; D006801:Humans; D010716:Phosphatidylinositols / Q000378:metabolism; D011987:Receptors, Steroid / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013261:Sterols / Q000378:metabolism*; D000098825:Oxysterol Binding Proteins
chemical_list: D010716:Phosphatidylinositols; D011987:Receptors, Steroid; D013261:Sterols; D000098825:Oxysterol Binding Proteins