title: Impact of an inflammation-based prognostic system on patients undergoing surgery for hepatocellular carcinoma: a retrospective study of 398 Japanese patients.
abstract: BACKGROUND
  Few studies have investigated the Glasgow Prognostic Score (GPS) in patients with hepatocellular carcinoma (HCC).
  
  
  METHODS
  This study compared the prognostic value of the GPS and Cancer of the Liver Italian Program (CLIP) score in patients undergoing surgery for HCC.
  
  
  RESULTS
  A total of 398 patients were evaluated retrospectively. Kaplan-Meier analyses revealed that GPS (P < .001) and CLIP score (P < .001) were associated with overall survival. GPS could classify patients with low CLIP score (0 or 1) into 3 independent groups (P < .001). Univariate analyses selected GPS (P = .006) and CLIP score (P = .002) as the predictive factors associated with overall survival. Multivariate analysis using these 2 scoring systems disclosed that both GPS (P = .025) and CLIP score (P = .010) were associated with overall survival.
  
  
  CONCLUSIONS
  GPS is not only an important predictor of overall survival after surgical treatment of HCC as well as CLIP score, but also is able to clearly divide patients with low CLIP score into 3 independent groups.
authors.affiliation: Department of Gastroenterological Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan. mm-ishizuka@umin.ac.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ishizuka
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kubota
authors.forename: Junji
authors.initials: J
authors.lastname: Kita
authors.forename: Mitsugi
authors.initials: M
authors.lastname: Shimoda
authors.forename: Masato
authors.initials: M
authors.lastname: Kato
authors.forename: Tokihiko
authors.initials: T
authors.lastname: Sawada
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007564:Japan; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D015996:Survival Rate