title: Major limitations of randomized clinical trials involving coronary artery bifurcation interventions: time for redesigning clinical trials by involving only true bifurcation lesions and using appropriate bifurcation classification.
abstract: Coronary bifurcation lesion intervention is technically challenging with higher complication rates. Many coronary interventional trials have been conducted involving coronary bifurcation lesions in order to compare one-stent with two-stent techniques. However, these trials have major limitation by enrolling all bifurcation lesions, including low-risk lesions so-called not true bifurcation lesions. This manuscript discusses the importance of appropriate designing of clinical trials for evaluation of complex techniques in coronary bifurcation lesions. (J Interven Cardiol 2011;24:295-301).
authors.affiliation: Southern Arizona VA Health Care System, Tucson, USA. rmovahed@email.arizona.edu
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Movahed
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D019917:Blood Vessel Prosthesis Implantation; D003324:Coronary Artery Disease / Q000145:classification / Q000628:therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D015607:Stents