title: microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review).
abstract: In the last decade, microRNAs (miRNAs; small noncoding RNA molecules) as post-transcriptional regulators have been a hotspot in research for their involvement in biological processes and tumour development. However, there have been few reviews focusing on a single miRNA family. The dysregulation of miRNAs appears to play a crucial role in cancer pathogenesis where they exert their effect as oncogenes or as tumour suppressors. This review summarises current studies on the dysregulation of the microRNA-34 (miR-34) family in different types of cancers and its role in the p53 network. The structure of the miR-34 family members includes p53-binding sites reflecting their function as tumour suppressors downstream of the p53 pathway. miR-34 dysregulation occurs in cancers, including several epithelial cancers, melanomas, neuroblastomas, leukemias and sarcomas, in the presence or absence of the p53 mutation. For these cancers, functional restoration of miR-34 is a useful novel therapy. As evidenced from preclinical and clinical studies, the miR-34 family plays an important role in the treatment of miR-34-dysregulated cancers with mutant or wild-type p53. This review will have a potential impact in the clinical treatment of p53-mutant and/or miR-34-dysregulated cancers using a miR-34 restoration approach.
authors.affiliation: Surgical and Orthopaedics Research Laboratories, Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors.forename: May Y W
authors.initials: MY
authors.lastname: Wong
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: William R
authors.initials: WR
authors.lastname: Walsh
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Yang
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000502:physiology*; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*
chemical_list: C522425:MIRN34 microRNA, human; D035683:MicroRNAs