title: [Effect of modified qianyang pellet on extravascular lung water and its correlated factors at the early fluid resuscitation stage of septic shock].
abstract: OBJECTIVE
  To investigate the effect of modified Qianyang Pellet (MQYP) on extravascular lung water and its correlated factors at the early fluid resuscitation stage of septic shock.
  
  
  METHODS
  Forty-eight patients with septic shock were randomly assigned to the treatment group (26 patients) and the control group (22 patients). They were treated with basic treatment combined with fluid resuscitation until the central venous pressure (CVP) reached > or = 8 mm Hg. Besides, patients in the treatment group received MQYP additionally. The haemodynamic indices, including CVP, cardiac index (CI), extravascular lung water index (EVLWI), systemic vascular resistance index (SVRI), global end-diastolic volume index (GEDVI), and oxygenation index (PaO2/ FiO2) were monitored at 8 (T8), 16 (T16) and 24 h (T24) after ending fluid resuscitation, and the 28-day mortality was observed.
  
  
  RESULTS
  Compared with the control group, CI, GEDVI and PaO2/FiO2 increased significantly at T8, T16 and T24, while EVLWI and 28-day mortality lowered in the treatment group (P < 0.05 or P < 0.01). But the difference in terms of CVP and SVRI between the two groups at corresponding time points was statistically insignificant (P > 0.05).
  
  
  CONCLUSIONS
  On the basis of the fluid resuscitation and basic treatment, MQYP could further improve CI, GEDVI and PaO2/FiO2, decrease EVLWI and 28-day mortality, but showed no effect on CVP or SVRI at the early fluid resuscitation stage of septic shock.
authors.affiliation: Emergency Department, Affiliated Hospital of Chengdu University of Chinese Medicine, Chengdu. wcx8297187@163.com
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Wang
authors.forename: Pei-Yang
authors.initials: PY
authors.lastname: Gao
authors.forename: Quan
authors.initials: Q
authors.lastname: Xie
mesh_terms: D000328:Adult; D000368:Aged; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015633:Extravascular Lung Water; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D012772:Shock, Septic / Q000188:drug therapy*
chemical_list: D004365:Drugs, Chinese Herbal