title: An iminocoumarin-Cu(II) ensemble-based chemodosimeter toward thiols.
abstract: An 'ensemble'-based fluoregenic chemodosimeter 1-Cu(II) for detection of thiols is reported. Complex 1-Cu(II) sensitively senses thiols followed by hydrolysis to give a marked fluorescence enhancement over other amino acids at pH 7.4 under aqueous media. Confocal microscopic imaging of complex 1-Cu(II) is also herewith demonstrated for cellular thiol detection in HepG2 cells.
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea.
authors.forename: Hyo Sung
authors.initials: HS
authors.lastname: Jung
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Han
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Habata
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D003300:Copper / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009942:Organometallic Compounds / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D003374:Coumarins; D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D003300:Copper