title: Dengue causing fulminant hepatitis in a hepatitis B virus carrier.
abstract: Dengue is an acute febrile illness resulting from infection by a flavivirus transmitted by the Aedes mosquito. It is characterized by bleeding manifestations and a plasma leak syndrome. Hepatic involvement in the form of elevation in transaminases is common. However, acute hepatic failure is uncommon. It is not known how the presence of an underlying chronic hepatitis or liver disease affects the likelihood of severity of hepatitis from dengue. The present report is of a 33-year-old man, a carrier of hepatitis B virus, who presented with fever, altered sensorium, thrombocytopenia, and coagulopathy. He was diagnosed to have developed acute hepatic failure due to dengue. The patient improved with supportive measures.
authors.affiliation: Department of Medicine, University College of Medical Sciences, University of Delhi, GTB Hospital, Delhi, India.
authors.forename: M P
authors.initials: MP
authors.lastname: Agarwal
authors.forename: S
authors.initials: S
authors.lastname: Giri
authors.forename: V
authors.initials: V
authors.lastname: Sharma
authors.forename: U
authors.initials: U
authors.lastname: Roy
authors.forename: K
authors.initials: K
authors.lastname: Gharsangi
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D000328:Adult; D002353:Carrier State / Q000821:virology*; D003715:Dengue / Q000150:complications*; D004797:Enzyme-Linked Immunosorbent Assay; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007194:India; D017114:Liver Failure, Acute / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D008297:Male; D016896:Treatment Outcome
chemical_list: D007075:Immunoglobulin M; D000082:Acetaminophen