title: One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis.
abstract: An efficient, easy to perform, one-pot reaction cascade for the synthesis of 2,5-disubstituted pyrroles from p-toluenesulfonyl protected imines and 4-nitrobut-1-yne under a combination of base and gold(III) catalysis is reported.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: David M
authors.initials: DM
authors.lastname: Barber
authors.forename: Hitesh
authors.initials: H
authors.lastname: Sanganee
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Dixon
mesh_terms: D000586:Amination; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008352:Mannich Bases / Q000737:chemistry; D009574:Nitro Compounds / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D008352:Mannich Bases; D009574:Nitro Compounds; D011758:Pyrroles; D006046:Gold