title: Lessons from seven decades of antituberculosis drug discovery.
abstract: Despite massive global efforts tuberculosis rates continue to climb and drug-resistance rates are rising to alarming levels. Discovering new agents for treating this bacterial pathogen poses unique challenges, but these challenges have been faced throughout the entire modern history of research into anti-infectives. This review looks back at every decade since the 1940s and summarizes the most important drugs developed during each decade highlighting the lessons learned during these successful medicinal chemistry programs. Looking forward we must accelerate the integration of these past lessons with the impressive advances that have been made in the basic understanding of the biology of this disease.
authors.affiliation: Tuberculosis Research Section, LCID, NIAID, NIH, Bethesda, MD, USA. cbarry@niaid.nih.gov
authors.forename: Clifton E
authors.initials: CE
authors.lastname: Barry
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000266:history* / Q000627:therapeutic use; D015195:Drug Design; D055808:Drug Discovery / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014376:Tuberculosis / Q000188:drug therapy / Q000266:history*
chemical_list: D000995:Antitubercular Agents