title: Pyrazinamide plasma concentrations in young children with tuberculosis.
abstract: Pyrazinamide plasma concentrations were determined in 34 children (median age, 3.32 years) 1 month after commencing antituberculosis treatment. The median (interquartile range) peak concentration was 30.7 (25.5, 35.0) mg/L after a median dose of 23 mg/kg. Peak concentrations < 20 mg/L were found in 5 children (15%) and such low concentrations were particularly likely after doses < 20 mg/kg.
authors.affiliation: Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
authors.forename: Helen
authors.initials: H
authors.lastname: McIlleron
authors.forename: Marianne
authors.initials: M
authors.lastname: Willemse
authors.forename: Hendrik Simon
authors.initials: HS
authors.lastname: Schaaf
authors.forename: Peter John
authors.initials: PJ
authors.lastname: Smith
authors.forename: Peter Roderick
authors.initials: PR
authors.lastname: Donald
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010949:Plasma / Q000737:chemistry*; D011718:Pyrazinamide / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide