title: Giant frontal colliding meningiomas in a child: histopathologic, cytogenetic, and ultrastructural descriptions of a unique case.
abstract: Meningiomas in the pediatric population are uncommon primary brain tumors, and rhabdoid meningiomas are exceedingly rare. We describe herein a 16-year-old female who presented with a giant frontal mass with intracranial and extracranial components. Histologic, immunohistochemical, and ultrastructural examinations showed the intracranial tumor to be rhabdoid meningioma, and the extracranial tumor was meningothelial meningioma. Cytogenetic study of the intracranial tumor showed monosomy 22, and the extracranial tumor showed allelic losses at 18p11.32. Because of the different cytogenetic findings and the absence of communication between these two tumors, we concluded that these tumors were separate and represent colliding meningiomas. Furthermore, the rhabdoid meningioma lacked obvious histologic evidence of malignancy. The presence of colliding meningiomas with different cytogenetic abnormalities as well as a rhabdoid meningioma showing no conspicuous evidence of malignancy have not been reported in children before.
authors.affiliation: Department of Pathology, Arkansas Children's Hospital, Little Rock, AR 72202, USA.
authors.forename: Siraj M
authors.initials: SM
authors.lastname: El Jamal
authors.forename: Ali
authors.initials: A
authors.lastname: Raja
authors.forename: Ali G
authors.initials: AG
authors.lastname: Saad
mesh_terms: D000293:Adolescent; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D003582:Cytogenetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000235:genetics / Q000473:pathology*; D008579:Meningioma / Q000235:genetics / Q000473:pathology*; D046529:Microscopy, Electron, Transmission; D009006:Monosomy; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D000071796:SMARCB1 Protein; D014157:Transcription Factors / Q000235:genetics
chemical_list: C431152:BCL2L13 protein, human; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; D014157:Transcription Factors