title: Imaging features of micropapillary DCIS: correlation with clinical and histopathological findings.
abstract: OBJECTIVE
  The aim of this study was to describe the mammographic, sonographic, and magnetic resonance imaging (MRI) findings of micropapillary ductal carcinoma in situ.
  
  
  METHODS
  Between May 2004 and April 2008, the pathology database of a single institution was reviewed for patients diagnosed with histologically proven DCIS with a predominant micropapillary component. Clinical data and preoperative imaging studies, including mammography, sonography, and/or MRI, were reviewed.
  
  
  RESULTS
  Forty-one patients (mean age, 55 years; range, 33-82 years) with 42 tumors were included in this study. Most tumors (n = 32 [76%]) were detected on screening mammography, with a mean tumor size of 4.7 cm (range, 0.5-13 cm). Of 42 tumors, seven (16%) were multicentric, and 23 (54%) were high nuclear grade. Calcifications were identified in 36 tumors (86%) on mammography, most frequently with pleomorphic morphology (15 tumors [42%]). Sonography was frequently normal (17 of 36 [47%]). When abnormal, irregular mass and angular margins were the most common sonographic features. All four tumors with MRI showed non-mass-like enhancement and showed the best correlation with pathologic size.
  
  
  CONCLUSIONS
  Micropapillary ductal carcinoma in situ is a unique subset of in situ cancer that is frequently clinically occult but has a large mean size at diagnosis and demonstrates highly suspicious features at imaging including pleomorphic calcifications on mammography and an irregular mass at sonography. MRI may be the imaging modality of choice for delineation of disease extent and warrants further validation.
authors.affiliation: Department of Diagnostic Radiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA.
authors.forename: Yien Sien
authors.initials: YS
authors.lastname: Lee
authors.forename: Jean
authors.initials: J
authors.lastname: Mathew
authors.forename: Basak E
authors.initials: BE
authors.lastname: Dogan
authors.forename: Erika
authors.initials: E
authors.lastname: Resetkova
authors.forename: Lei
authors.initials: L
authors.lastname: Huo
authors.forename: Wei Tse
authors.initials: WT
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D013223:Statistics as Topic