title: Methylococcus capsulatus (Bath) from genome to protein function, and vice versa.
abstract: The genome sequence of Methylococcus capsulatus (Bath), considered a model methylotroph, was published in 2004 [Ward, N., et al. (2004). Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath). PLoS Biol.2, e303]. In the postgenomic era, the challenge is to determine the gene function, and to this end, genomics must be complemented with proteomic approaches. This chapter describes some experimental and computational approaches we have used and developed for the exploration of the genome and proteome of M. capsulatus (Bath).
authors.affiliation: Department of Molecular Biology, University of Bergen, Bergen, Norway.
authors.forename: Odd A
authors.initials: OA
authors.lastname: Karlsen
authors.forename: Frode S
authors.initials: FS
authors.lastname: Berven
authors.forename: June I
authors.initials: JI
authors.lastname: Bagstevold
authors.forename: Oivind
authors.initials: O
authors.lastname: Larsen
authors.forename: Harald B
authors.initials: HB
authors.lastname: Jensen
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D016680:Genome, Bacterial; D023281:Genomics / Q000379:methods; D006420:Hemeproteins / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification; D020619:Methylococcus capsulatus / Q000737:chemistry* / Q000235:genetics; D040901:Proteomics / Q000379:methods*
chemical_list: D001426:Bacterial Proteins; D006420:Hemeproteins