title: Exploration of the disease locus by a careful evaluation of the likelihood polynomial for pedigree data.
abstract: It is demonstrated through two case studies that a careful evaluation of the likelihood polynomial results in a more accurate localization of disease locus. The evaluation of the likelihood function as a polynomial enables more flexible exploration of the disease locus. Visualization by a contour plot of the function on a unit square of paternal and maternal recombination fractions along with a superimposed ellipsoid of the Fisher information matrix helps us to find a more accurate localization of the disease locus.
authors.affiliation: School of Fundamental Science and Technology, Keio University, Yokohama, Japan. sugaya@stat.math.keio.ac.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sugaya
authors.forename: Ritei
authors.initials: R
authors.lastname: Shibata
mesh_terms: D005260:Female; D056426:Genetic Loci; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006073:Gout / Q000235:genetics*; D006801:Humans; D033461:Hyperuricemia / Q000235:genetics*; D007674:Kidney Diseases / Q000235:genetics*; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D011995:Recombination, Genetic