title: Structures and folding pathways of topologically knotted proteins.
abstract: In the last decade, a new class of proteins has emerged that contain a topological knot in their backbone. Although these structures are rare, they nevertheless challenge our understanding of protein folding. In this review, we provide a short overview of topologically knotted proteins with an emphasis on newly discovered structures. We discuss the current knowledge in the field, including recent developments in both experimental and computational studies that have shed light on how these intricate structures fold.
authors.affiliation: Institut für Physik, Johannes Gutenberg-Universität Mainz, Staudinger Weg 7, 55128 Mainz, Germany. virnau@uni-mainz.de
authors.forename: Peter
authors.initials: P
authors.lastname: Virnau
authors.forename: Anna
authors.initials: A
authors.lastname: Mallam
authors.forename: Sophie
authors.initials: S
authors.lastname: Jackson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003196:Computer Graphics; D003198:Computer Simulation; D030562:Databases, Protein; D006801:Humans; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins