title: Synthesis of 2-(N-Benzylpyrrolyl)-benzimidazoles Using Polyphosphoric Acid Prompted Cyclocondensation.
abstract: Synthesis of a series of 2-substituted benzimidazoles was carried out for screening anti-inflammatory activities. 2-(N-benzylpyrrolyl)-benzimidazoles 9a-k were synthesized from N-benzyl-2-pyrrole carboxylic acids 8a-d and 4-substituted-1,2-phenylenediamines by cyclocondensation utilizing polyphosphoric acid (PPA) as condensing agent. The N-benzyl-2-pyrrole carboxylic acids were prepared by standard method of N-benzylation of 2-pyrrole carboxylate using NaH/DMF and appropriately substituted benzyl halides followed by alkaline hydrolysis.
authors.affiliation: Department of Chemistry, College of Arts and Sciences, Florida A&M University, Tallahassee, Florida 32307.
authors.forename: Bereket
authors.initials: B
authors.lastname: Mochona
authors.forename: Laine
authors.initials: L
authors.lastname: Le
authors.forename: Madhavi
authors.initials: M
authors.lastname: Gangapuram
authors.forename: Nelly
authors.initials: N
authors.lastname: Mateeva
authors.forename: Tiffany
authors.initials: T
authors.lastname: Ardley
authors.forename: Kinfe K
authors.initials: KK
authors.lastname: Redda