title: [Focal nodular hyperplasia of liver: a clinicopathologic study of 238 patients].
abstract: OBJECTIVE
  To study the clinicopathologic features of focal nodular hyperplasia (FNH) of liver.
  
  
  METHODS
  The clinical, radiologic, pathologic findings and follow-up data of 238 cases of FNH were retrospectively analyzed.
  
  
  RESULTS
  The patients included 93 females and 145 males. The age of the patients ranged from 11 to 77 years (median = 39.1 years). Amongst the 233 patients who had clinical information available, 188 were asymptomatic, 216 had no history of hepatitis B and/or C infection and 232 had negative serum alpha-fetoprotein level. Amongst the 185 patients who had undergone radiologic examination, 123 (66.5%) were accurately diagnosed as such. Macroscopically, of the 284 lesions from 238 patients, the average diameter was 3.7 cm. Two hundred and fifteen cases (90.3%) were solitary, 172 cases were located in the right lobe and 115(40.5%) had central stellate fibrotic scars or lobulated cut surface. Histologically, 229 lesions belonged to classic type and 9 lesions were of non-classic type. The latter was further classified as the telangiectatic form (6 lesions) and the mixed hyperplastic and adenomatous form (3 lesions). There was no evidence of significant cytologic atypia. Follow-up data were available in 173 patients (72.7%). None of them died of the disease and 2 patients suffered from relapses after 2 and 4 years, respectively.
  
  
  CONCLUSIONS
  FNH is a hyperplastic response of normal liver cells to local blood flow anomalies. It has no obvious sex predilection and more than 66% can be diagnosed accurately with radiologic examination. The lesions in the current study show no cytologic atypia.
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Ling-li
authors.initials: LL
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ji
authors.forename: Jian-fang
authors.initials: JF
authors.lastname: Xu
authors.forename: Shao-hua
authors.initials: SH
authors.lastname: Lu
authors.forename: Ying-yong
authors.initials: YY
authors.lastname: Hou
authors.forename: Jun
authors.initials: J
authors.lastname: Hou
authors.forename: Akesu
authors.initials: A
authors.lastname: Sujie
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Zeng
authors.forename: Yun-shan
authors.initials: YS
authors.lastname: Tan
mesh_terms: D018248:Adenoma, Liver Cell / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D055815:Young Adult