title: [Prophylaxis of coagulopathic bleeding in pregnant patient of high-risk during delivery].
abstract: A clinic, laboratory and Doppler ultrasound study including women with a high risk of coagulopathic bleeding in delivery was carried out. When indicated, a coagulopathic bleeding prophylaxis was performed with administration of the tranexamic acid or with autotransfusion of the pre-stored fresh frozen plasma. Also, a reinfusion of washed red blood cells was performed using a Cell Saver. It was found out that the infusion of tranexamic acid during surgical delivery in severe gestosis patients has significantly reduced the intraoperative blood loss and prevented the coagulopathic bleeding. Autotransfusion of plasma has favoured the recovery of blood clotting potential during and after the delivery. The obtained data have shown the safety of preparing the auto-plasma for both pregnant and foetus. The results of study prove the possibility of reducing the use of donor blood components with the aid of modern blood-saving technologies.
authors.forename: D R
authors.initials: DR
authors.lastname: Bikmullina
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Borisov
authors.forename: M S
authors.initials: MS
authors.lastname: Zaĭnulina
mesh_terms: D000328:Adult; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D001804:Blood Transfusion, Autologous / Q000379:methods*; D002585:Cesarean Section; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000097:blood / Q000517:prevention & control*; D011247:Pregnancy; D018566:Pregnancy, High-Risk / Q000097:blood*; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid