title: Antibacterial properties of compounds isolated from Carpobrotus edulis.
abstract: Several compounds isolated from the plant Carpobrotus edulis were evaluated for their activity against multidrug-resistant (MDR) bacteria and their efflux pump systems. Amongst the compounds isolated, six compounds were tested, namely uvaol, β-amyrin, oleanolic acid, catechin, epicatechin and monogalactosyldiacylglycerol. Oleanolic acid presented high antibacterial activity against a large number of bacterial strains. The triterpene uvaol was the most active compound for modulation of efflux activity by MDR Gram-positive strains.
authors.affiliation: Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349-008 Lisbon, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Martins
authors.forename: A
authors.initials: A
authors.lastname: Vasas
authors.forename: M
authors.initials: M
authors.lastname: Viveiros
authors.forename: J
authors.initials: J
authors.lastname: Molnár
authors.forename: J
authors.initials: J
authors.lastname: Hohmann
authors.forename: L
authors.initials: L
authors.lastname: Amaral
mesh_terms: D035722:Aizoaceae / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009828:Oleanolic Acid / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D014315:Triterpenes; D009828:Oleanolic Acid; C013330:uvaol