title: [Retinal autofluorescence imaging in patients with pseudoxanthoma elasticum].
abstract: OBJECTIVE
  To evaluate the autofluorescence findings in patients diagnosed with pseudoxanthoma elasticum.
  
  
  METHODS
  A prospective study was conducted on 18 eyes of 9 patients who had ocular pathology andfollowed up in the pseudoxanthoma elasticum (PSX) unit of our hospital. We evaluated the best corrected visual acuity (BCVA), colour and autofluorescence photography (AF), and fluorescein angiography (FA) in patients with choroidal neovascularitation.
  
  
  RESULTS
  Of the 9 patients, 7 were women and 2 were men. The mean age was 40 +/- 14 years. The BCVA ranged from 1 to 0.01 (Mean 0.65 +/- 0.4). All patients showed PSX injuries. Angioid streaks (AS) 18 (100%), peau d'orange 16 (87.5%) and pigmented fibrotic plates 5 (31,5%). We observed different hypoautofluorescence patterns (RPE atrophy), of which 2 of them were AS patterns (irregular lines with hyperautofluorescence speckled in its interior and edges, or bands with lobulated lesions inside and hyperautofluorescence at the edges), and finally widespread areas of hypoautofluorescence, larger than observed by ophthalmoscope.
  
  
  CONCLUSIONS
  Autofluorescence in patients with PSX is an easy method to evaluate the initial level of ophthalmoscopic involvement and its subsequent progression. The extensive changes in the retinal pigment epithelium (RPE) suggests the important role of this in the physiopathology of the disease.
authors.affiliation: Servicio de Oftalmología, Hospital Universitario Virgen de la Victoria, Málaga, España. dramorillo@hotmail.com
authors.forename: M J
authors.initials: MJ
authors.lastname: Morillo
authors.forename: J
authors.initials: J
authors.lastname: Mora
authors.forename: A
authors.initials: A
authors.lastname: Soler
authors.forename: J M
authors.initials: JM
authors.lastname: García-Campos
authors.forename: I
authors.initials: I
authors.lastname: García-Fernández
authors.forename: P
authors.initials: P
authors.lastname: Sánchez
authors.forename: P
authors.initials: P
authors.lastname: Valdivieso
mesh_terms: D000328:Adult; D000793:Angioid Streaks / Q000209:etiology / Q000473:pathology; D001284:Atrophy; D020256:Choroidal Neovascularization / Q000209:etiology; D005260:Female; D005355:Fibrosis; D005451:Fluorescein Angiography; D005453:Fluorescence; D005470:Fluorometry; D006801:Humans; D008062:Lipofuscin / Q000032:analysis* / Q000737:chemistry; D008247:Lysosomes / Q000737:chemistry / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods*; D011446:Prospective Studies; D011561:Pseudoxanthoma Elasticum / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D055213:Retinal Pigment Epithelium / Q000098:blood supply / Q000473:pathology*; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D008062:Lipofuscin