title: Omalizumab treatment of systemic mast cell activation disease: experiences from four cases.
abstract: We report on the outcome of 4 patients with therapy-resistant systemic mast cell activation disease (MCAD) treated with the anti-IgE monoclonal antibody omalizumab in compassionate use. Two patients achieved an impressive persistent clinical response to treatment with omalizumab. In the third patient symptoms gradually improved. In the fourth patient omalizumab treatment had to be discontinued due to intolerable mast cell mediator-induced symptoms. In conclusion, omalizumab can lessen the intensity of the symptoms of systemic MCAD. Hence, omalizumab should be considered as a therapeutic option in cases of systemic MCAD that are resistant to evidence-based therapy.
authors.affiliation: Institute of Human Genetics, University Hospital of Bonn, Germany. molderings@uni-bonn.de
authors.forename: Gerhard J
authors.initials: GJ
authors.lastname: Molderings
authors.forename: Martin
authors.initials: M
authors.lastname: Raithel
authors.forename: Felix
authors.initials: F
authors.lastname: Kratz
authors.forename: Marc
authors.initials: M
authors.lastname: Azemar
authors.forename: Britta
authors.initials: B
authors.lastname: Haenisch
authors.forename: Sabrina
authors.initials: S
authors.lastname: Harzer
authors.forename: Jürgen
authors.initials: J
authors.lastname: Homann
mesh_terms: D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D057176:Compassionate Use Trials; D005260:Female; D006801:Humans; D008297:Male; D034721:Mastocytosis, Systemic / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D008875:Middle Aged; D000069444:Omalizumab; D016896:Treatment Outcome
chemical_list: D000888:Antibodies, Anti-Idiotypic; D061067:Antibodies, Monoclonal, Humanized; C026408:anti-IgE antibodies; D000069444:Omalizumab