title: Ionic liquid promoted synthesis, antibacterial and in vitro antiproliferative activity of novel α-aminophosphonate derivatives.
abstract: Ionic liquid ethyl ammonium nitrate is used as an excellent catalyst and solvent for three-component one-pot reaction of an aldehydes, amines and diethylphosphite to form novel α-aminophosphonates at room temperature. Among the various catalysts, the preparation of ethyl ammonium nitrate is an environmental friendly, cost effective and recyclable catalyst. Compounds 4b, 4c, 4d, 4f and 4j were found more potent antibacterials against pathogenic microorganisms. Whereas, compounds 4a, 4g, 4h and 4j inhibits growth of active Escherichia coli NCIM 2645 and Salmonella typhi NCIM 2501. Compound 4j was found a promising antiproliferative agent against A549 and SK-MEL2 human melanoma cell lines.
authors.affiliation: Organic Synthesis Laboratory, Department of Chemistry, Dnyanopasak College, Parbhani-431401, (MS), India.
authors.forename: Satish A
authors.initials: SA
authors.lastname: Dake
authors.forename: Dnyaneshwar S
authors.initials: DS
authors.lastname: Raut
authors.forename: Kiran R
authors.initials: KR
authors.lastname: Kharat
authors.forename: Rooth S
authors.initials: RS
authors.lastname: Mhaske
authors.forename: Satish U
authors.initials: SU
authors.lastname: Deshmukh
authors.forename: Rajendra P
authors.initials: RP
authors.lastname: Pawar
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D002384:Catalysis; D045744:Cell Line, Tumor; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009566:Nitrates / Q000737:chemistry; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D052578:Ionic Liquids; D009566:Nitrates; D063065:Organophosphonates; C006568:ammonium nitrate