title: Clinical application of Chamomilla recutita in phlebitis: dose response curve study.
abstract: This experimental and dose-response curve study aimed to carry out the quality control of the Chamomilla recutita sample, as well as to estimate the ideal dose, for anti-inflammatory effect, of the extract of its capitula, in patients with phlebitis due to peripheral intravenous infusion of antineoplastic chemotherapy and to evaluate the toxicity of this extract in human beings. The therapeutic efficacy, concerning the anti-inflammatory potential, of different doses of Chamomilla recutita extract were analyzed and compared in 25 patients. The time of regression of phlebitis was shorter for groups with 2.5% concentration (mean=29.2h, standard deviation = 8.98) and 5% concentration (mean = 38.8h, standard deviation = 17.47). Local toxicity was almost not observed. This research contributes to the innovation of the nursing clinical practice, since it suggests an alternative for the treatment of phlebitis through the clinical use of phytotherapeutic drugs.
authors.affiliation: Universidade de Brasília, DF, Brazil. pdinizreis@yahoo.com
authors.forename: Paula Elaine Diniz Dos
authors.initials: PE
authors.lastname: Reis
authors.forename: Emilia Campos de
authors.initials: EC
authors.lastname: Carvalho
authors.forename: Paula Carolina Pires
authors.initials: PC
authors.lastname: Bueno
authors.forename: Jairo Kenupp
authors.initials: JK
authors.lastname: Bastos
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D031168:Matricaria; D010689:Phlebitis / Q000188:drug therapy*; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage*
chemical_list: D028321:Plant Preparations