title: Pharmacological developments obtained from marine natural products and current pipeline perspective.
abstract: Marine organisms represent a new extensive source for bioactive molecules. They have the potential to provide new therapeutic alternatives to treat human diseases. In this paper, we describe and discuss a variety of isolated and semisynthetic molecules obtained from marine sources. These compounds are in phase II, phase III and at the commercialization stage of new drug development. A description of the mechanism of action, dosage used and side effects are also reported. The positive results obtained from these studies have triggered the development of new studies to evaluate the prospects for utilization of marine organisms.
authors.affiliation: Marine Natural Products Research Group, School of Pharmaceutical Chemistry, The University of Antioquia, Medellin, Colombia. elgaja@gmail.com
authors.forename: Elkin
authors.initials: E
authors.lastname: Galeano
authors.forename: Jhon J
authors.initials: JJ
authors.lastname: Rojas
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martínez
mesh_terms: D000818:Animals; D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology*; D055808:Drug Discovery; D009792:Oceans and Seas
chemical_list: D001688:Biological Products