title: Sodium mercaptoundecahydro-closo-dodecaborate (BSH), a boron carrier that merits more attention.
abstract: Boron neutron capture therapy relies on the preferential delivery of a (10)B-compound to tumor cells. The BSH-biodistribution was investigated in nu/nu mice and human patients. The boron concentration was measured with prompt gamma ray spectroscopy. BSH accumulates to a very low extent not only in brain, but also in fat tissue, bone and muscle, which makes BSH an interesting drug not only for brain lesions but also for tumors located at the extremities. The differential uptake in different organs indicates a complex mechanism.
authors.affiliation: Department of Radiotherapy and Radiation Oncology, University Hospital Giessen and Marburg, Philipps-University Marburg, Marburg, Germany. wittig@med.uni-marburg.de
authors.forename: Andrea
authors.initials: A
authors.lastname: Wittig
authors.forename: Finn
authors.initials: F
authors.lastname: Stecher-Rasmussen
authors.forename: Ralf A
authors.initials: RA
authors.lastname: Hilger
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rassow
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Mauri
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sauerwein
mesh_terms: D000818:Animals; D001894:Borohydrides / Q000737:chemistry / Q000493:pharmacokinetics*; D001895:Boron / Q000737:chemistry*; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D001894:Borohydrides; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D001895:Boron