title: Common genomic aberrations in basaloid squamous cell carcinoma and carcinosarcoma of the esophagus detected by CGH and array CGH.
abstract: Basaloid squamous cell carcinoma (BSCC) and carcinosarcoma of the esophagus are rare entities, making up fewer than 2% of esophageal malignancies. Comparative genomic hybridization (CGH) in 1 case of BSCC and 2 cases of carcinosarcoma and subsequent array CGH in 1 case each of BSCC and carcinosarcoma revealed common chromosomal gains at 2p25.3-2p12, 7q21.3-7q22.3, and 11q13.2-11q13.4. Chromosomal losses at 13q31qter were observed in both carcinosarcomas. In addition, progression of genomic instability from in situ to invasive carcinosarcoma could be demonstrated by using array CGH. Our observations suggest a common genetic origin of BSCC and carcinosarcoma.
authors.affiliation: Dept of Gastroenteropathology, University Medical Center Göttingen, Germany.
authors.forename: Inga-Marie
authors.initials: IM
authors.lastname: Schaefer
authors.forename: Christina
authors.initials: C
authors.lastname: Enders
authors.forename: Andreas
authors.initials: A
authors.lastname: Polten
authors.forename: Florian
authors.initials: F
authors.lastname: Haller
authors.forename: Andreas M J
authors.initials: AM
authors.lastname: Frölich
authors.forename: Silke
authors.initials: S
authors.lastname: Cameron
authors.forename: Philipp
authors.initials: P
authors.lastname: Schüler
authors.forename: Peter
authors.initials: P
authors.lastname: Schweiger
authors.forename: Bastian
authors.initials: B
authors.lastname: Gunawan
authors.forename: Alexander
authors.initials: A
authors.lastname: Beham
authors.forename: László
authors.initials: L
authors.lastname: Füzesi
mesh_terms: D000368:Aged; D002278:Carcinoma in Situ / Q000235:genetics / Q000473:pathology / Q000601:surgery; D002280:Basal Cell Carcinoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002281:Carcinoma, Basosquamous / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002296:Carcinosarcoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D055028:Comparative Genomic Hybridization / Q000379:methods*; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D014057:Tomography, X-Ray Computed