title: A rare case of oral epithelioid sarcoma of the gingiva.
abstract: Epithelioid sarcoma (ES) is a rare malignant soft tissue tumor. ES can be classified into proximal, distal, and fibroma-like subtypes. These tumors show both mesenchymal and epithelial immunophenotypes. Microscopically, the proximal type ES is usually characterized by nodules of spindle and epithelioid cells growing in granuloma-like pattern often presenting with central necrosis. Immunohistochemically these tumors are vimentin, pancytokeratin, and usually EMA (80%) positive. CD34 (50%) and CD99 (25%) may be positive, and occasionally SMA and S-100 immunopositivity has been reported. No specific genetic alterations have been found in ES. As far as we know, this is the first case in the literature to present ES in gingival mucosa.
authors.affiliation: Department of Pathology/Haartman Institute and HusLab, Helsinki University Central Hospital, Helsinki, Finland. jaana.hagstrom@hus.fi
authors.forename: Jaana
authors.initials: J
authors.lastname: Hagström
authors.forename: Karri
authors.initials: K
authors.lastname: Mesimäki
authors.forename: Satu
authors.initials: S
authors.lastname: Apajalahti
authors.forename: Caj
authors.initials: C
authors.lastname: Haglund
authors.forename: Mikko
authors.initials: M
authors.lastname: Rönty
authors.forename: Maarit
authors.initials: M
authors.lastname: Sarlomo-Rikala
mesh_terms: D000071443:12E7 Antigen; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D003893:Desmin / Q000032:analysis; D003937:Diagnosis, Differential; D005887:Gingival Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D008334:Mandible; D012509:Sarcoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000032:analysis
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D003893:Desmin; D014746:Vimentin; D007633:Keratins