title: Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis.
abstract: Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.
authors.affiliation: The Binding Site, Birmingham, UK. stephen.harding@bindingsite.co.uk
authors.forename: Stephen
authors.initials: S
authors.lastname: Harding
authors.forename: Francois
authors.initials: F
authors.lastname: Provot
authors.forename: Jean-Baptise
authors.initials: JB
authors.lastname: Beuscart
authors.forename: Mark
authors.initials: M
authors.lastname: Cook
authors.forename: Arthur R
authors.initials: AR
authors.lastname: Bradwell
authors.forename: Stephanie
authors.initials: S
authors.lastname: Stringer
authors.forename: Darren
authors.initials: D
authors.lastname: White
authors.forename: Paul
authors.initials: P
authors.lastname: Cockwell
authors.forename: Colin A
authors.initials: CA
authors.lastname: Hutchison
mesh_terms: D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000628:therapy; D006435:Renal Dialysis
chemical_list: D007147:Immunoglobulin Light Chains