title: Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis.
abstract: The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. We reexamined both interactions for lifetime MDD in a college sample. Lifetime MDD was diagnosed by Structured Clinical Interview for DSM-IV in 133 undergraduates; genotypes for 5-HTTLPR and BDNF were assayed from blood, and self-reports were collected concerning childhood adversity (Risk). 5-HTTLPR interacted with Risk such that Risk predicted less likelihood of MDD among ll carriers and tended to predict greater likelihood of MDD among s carriers. BDNF interacted with Risk such that Risk predicted greater likelihood of MDD among met carriers and did not influence val/val carriers. These two interactions were additive: both were significant in a combined model.
authors.affiliation: Department of Psychology, University of Miami, Coral Gables FL 33124, United States. ccarver@miami.edu
authors.forename: Charles S
authors.initials: CS
authors.lastname: Carver
authors.forename: Sheri L
authors.initials: SL
authors.lastname: Johnson
authors.forename: Jutta
authors.initials: J
authors.lastname: Joormann
authors.forename: Joelle
authors.initials: J
authors.lastname: Lemoult
authors.forename: Michael L
authors.initials: ML
authors.lastname: Cuccaro
mesh_terms: D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004843:Epistasis, Genetic / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins