title: Minimal change glomerulopathy in a cat.
abstract: A 6-year-old domestic shorthair male castrated cat was evaluated for sudden onset of vomiting and anorexia. A diagnosis of hypereosinophilic syndrome (HES) was made, and the cat was treated with imatinib mesylate. The cat had an initial clinical improvement with the normalization of the peripheral eosinophil count. After approximately 8 weeks of treatment, lethargy and anorexia recurred despite the normal eosinophil count and a significant proteinuric nephropathy was identified. Treatment with imatinib was discontinued. Ultrasound guided renal biopsies exhibited histologic, ultrastructural, and immunostaining changes indicative of a minimal change glomerulopathy (MCG) which has not previously been reported in the literature in a cat. The proteinuria and HES initially improved while the cat was treated with more traditional medications; however, both the problems persisted for 30 months that the cat was followed subsequently. Previous studies demonstrating the safety and efficacy of imatinib in cats do not report any glomerular injury or significant adverse drug reactions, and the exact cause of this cat's proteinuric nephropathy is uncertain. Nonetheless, the possibility of an adverse drug reaction causing proteinuria should be considered when initiating treatment with imatinib in a cat.
authors.affiliation: Department of Small Animal Clinical Sciences, Texas A&M College of Veterinary Medicine and Biomedical Sciences, College Station, TX, USA. bbacklund@piepermemorial.com
authors.forename: Brianna
authors.initials: B
authors.lastname: Backlund
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Cianciolo
authors.forename: Audrey K
authors.initials: AK
authors.lastname: Cook
authors.forename: Fred J
authors.initials: FJ
authors.lastname: Clubb
authors.forename: George E
authors.initials: GE
authors.lastname: Lees
mesh_terms: D000818:Animals; D001549:Benzamides; D002371:Cat Diseases / Q000175:diagnosis* / Q000188:drug therapy; D002415:Cats; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D000068877:Imatinib Mesylate; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D009402:Nephrosis, Lipoid / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D011505:Protein-Tyrosine Kinases