title: Gene mutations, epigenetic dysregulation, and personalized therapy in myeloid neoplasia: are we there yet?
abstract: Myeloid neoplasms are characterized by acquired somatic mutations and epigenetic alterations in genes that are crucial for hematopoietic differentiation and cellular proliferation and survival pathways. The heterogeneity and genetic complexity of these disorders is daunting, but the improvement in our knowledge of the pathogenetic mechanisms underlying myeloid transformation, coupled with the increasing availability of agents that target these pathways, offers unique opportunities for improved therapy. This review will focus on common mutations that are of therapeutic or prognostic importance in acute myeloid leukemia (AML) and the classic Philadelphia chromosome-negative myeloproliferative neoplasms (Ph(-) MPNs), in the context of discussing the potential for risk-adapted and targeted therapeutic approaches for these diseases.
authors.affiliation: Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. todenike@medicine.bsd.uchicago.edu
authors.forename: Olatoyosi
authors.initials: O
authors.lastname: Odenike
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Thirman
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Artz
authors.forename: Lucy A
authors.initials: LA
authors.lastname: Godley
authors.forename: Richard A
authors.initials: RA
authors.lastname: Larson
authors.forename: Wendy
authors.initials: W
authors.lastname: Stock
mesh_terms: D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics; D050660:Core Binding Factors / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D049308:Dioxygenases; D057890:Epigenomics; D011905:Genes, ras; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009154:Mutation; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics; D009196:Myeloproliferative Disorders / Q000235:genetics*; D057285:Precision Medicine; D011518:Proto-Oncogene Proteins / Q000235:genetics; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human; D050660:Core Binding Factors; D004268:DNA-Binding Proteins; C497422:KMT2A protein, human; D011518:Proto-Oncogene Proteins; D051788:Myeloid-Lymphoid Leukemia Protein; D049308:Dioxygenases; C541081:TET2 protein, human; D011495:Histone-Lysine N-Methyltransferase; C497970:FLT3 protein, human; D019009:Proto-Oncogene Proteins c-kit; D051941:fms-Like Tyrosine Kinase 3; C507924:JAK2 protein, human; D053614:Janus Kinase 2