title: [Clinical characteristics of fat replacement of left ventricular myocardium].
abstract: OBJECTIVE
  To evaluate the clinical characteristics of left ventricular fat replacement.
  
  
  METHODS
  We identified 45 patients [28M/17F, mean age (51.9 ± 14.7) years] with left ventricular myocardial fat replacement (CT value ≤ -30 Hu) by cardiovascular CT.
  
  
  RESULTS
  Among 45 patients, 25 patients [20M/5F, mean age (61.2 ± 10.4) years]were diagnosed as coronary artery disease (CAD). There was 56%single-vessel disease, 20% double-vessel disease and 24%triple-vessel disease, true left ventricular aneurysm was detected in 3 patients and left ventricular thrombi in 1 patient, the dimension of left ventricle was (54.5 ± 9.4) mm and the LVEF was (51.8 ± 13)% in CAD group. In this group, fat replacement occurred in the region of myocardial infarction and presented as curvilinear band in subendocardial region. The left ventricular wall thickness was lower than 5 mm in 21 cases. The location of fat replacement in CAD group is as follows: apical region in 18 patients, distal septal in 15 patients, distal anterior in 11 patients, mid-septal in 7 patients, mid-anterior in 7 patients and basal in 1 patients. The age of remaining 20 patients (8M/12F) without CAD were (57.8 ± 13.3) years. In the group of non-CAD, dilated cardiomyopathy was diagnosed in 3 patients, atrial septal defect in 1 patient, rheumatic heart disease in 1 patient, there was no structural heart disease in the remaining 15 patients. The dimension of left ventricle was (51.1 ± 9.1) mm and the LVEF was (59.4 ± 13.9)%. In non-CAD group, fat replacement mainly occurred in septal region, presented as curvilinear band in 17 patients and patch in 3 patients. The location of fat replacement in this group is as follows: mid-septal region in 11 patients, distal-septal in 10 patients and apical in 9 patients. The intramural fat replacement was detected in 14 patients: subendocardial fat replacement in 10 patients and both intramural and subendocardial fat replacement in 4 patients.
  
  
  CONCLUSIONS
  Left ventricular fat replacement could be documented in CAD patients, non-CAD cardiomyopathy patients and in patients without structural heart disease. Left ventricular fat replacement often positioned in apical region in CAD patients as a consequence of infarct healing while mostly positioned in septal region in non-CAD patients, the definite clinical implication of left ventricular fat replacement in non-CAD patients remains to be clarified.
authors.affiliation: Department of Radiology, Chinese Academy of Medical Sciences, Beijing 100037, China. chaowu_yan@yahoo.com.cn
authors.forename: Chao-wu
authors.initials: CW
authors.lastname: Yan
authors.forename: Shi-hua
authors.initials: SH
authors.lastname: Zhao
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Shi-liang
authors.initials: SL
authors.lastname: Jiang
authors.forename: Jian
authors.initials: J
authors.lastname: Ling
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Lü
authors.forename: Min-jie
authors.initials: MJ
authors.lastname: Lu
authors.forename: Yun-qing
authors.initials: YQ
authors.lastname: Wei
authors.forename: Cheng
authors.initials: C
authors.lastname: Cao
authors.forename: Xiao-ou
authors.initials: XO
authors.lastname: Qi
authors.forename: Min-fu
authors.initials: MF
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000273:Adipose Tissue / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D009206:Myocardium / Q000166:cytology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology