title: Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma.
abstract: Merkel cell polyomavirus (MCPyV) is a novel polyomavirus that shows a strong association with Merkel cell carcinoma (MCC). Recent studies have demonstrated MCPyV in some cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a malignancy with a similar demographic as MCC. We tested for the presence of MCPyV by PCR and immunohistochemistry in 18 cases of CLL/SLL. Very low-level MCPyV DNA was detected in 33% of CLL/SLL cases by real-time PCR, but only one case demonstrated immunohistochemical positivity for MCPyV. MCPyV was not identified in 17 cases of follicular lymphoma, suggesting either that MCPyV is involved in CLL/SLL pathogenesis or that the immunodeficiency state of CLL/SLL induces low-level MCPyV reactivation.
authors.affiliation: Department of Pathology, University of Utah, Salt Lake City, UT 84108, USA.
authors.forename: Carolin J
authors.initials: CJ
authors.lastname: Teman
authors.forename: Sheryl R
authors.initials: SR
authors.lastname: Tripp
authors.forename: Sherrie L
authors.initials: SL
authors.lastname: Perkins
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Duncavage
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011120:Polyomavirus / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D027601:Polyomavirus Infections / Q000150:complications* / Q000378:metabolism / Q000821:virology
chemical_list: D004279:DNA, Viral