title: Green tea aqueous extract reduces visceral fat and decreases protein availability in rats fed with a high-fat diet.
abstract: Green tea is associated with beneficial health effects mainly because of its body fat-reducing and hypocholesterolemic activities, but an effective dose without pronounced influence on protein availability is unknown. The objective of this study was to examine the hypothesis that green tea aqueous extract (GTAE) depending on dose improves cardiovascular risk indicators such as body weight, visceral fat content, and atherogenic index of plasma and does not have unfavorable effect on protein availability in rats fed with a high-fat diet. The rats fed with a high-fat diet enriched with 1.1 and 2.0% GTAE for 8 weeks had significantly (P < .05) lower atherogenic index (in both groups, about 14.3%). Only administration of 2.0% GTAE significantly (P < .05) decreased body weight gain (5.6%) and prevented visceral fat accumulation (17.8%) in rats. However, considerably (P < .05), reduction in the digestion of protein (but not fat) was observed in both GTAE groups (1.1% GTAE: 82.6% ± 1.8%; 2.0% GTAE: 84.3% ± 0.8%) when compared to the control (93.3% ± 1.5%). It was concluded that GTAE may have preventive effects on the accumulation of visceral fat but only in higher doses. Although both doses improved cardiovascular risk indicators, they, in addition, significantly inhibited protein digestion.
authors.affiliation: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, 60-624 Poznan, Poland. joanna.bajerska@up.poznan.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Bajerska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wozniewicz
authors.forename: Jan
authors.initials: J
authors.lastname: Jeszka
authors.forename: Slawomira
authors.initials: S
authors.lastname: Drzymala-Czyz
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Walkowiak
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D018753:Diet, Protein-Restricted; D004041:Dietary Fats / Q000008:administration & dosage*; D050152:Intra-Abdominal Fat / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011506:Proteins / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D013662:Tea / Q000737:chemistry*; D015431:Weight Loss
chemical_list: D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D010936:Plant Extracts; D011506:Proteins; D013662:Tea