title: Leveraging therapeutic potential of multi-targeted siRNA inhibitors.
abstract: While the discovery of RNA interference (RNAi) has been considered one of the most significant breakthroughs in biomedicine, its prospects for novel therapeutic applications are even more exciting. The high specificity, exquisite selectivity and chemical homogeneity of small interfering RNAs (siRNA; intermediates in RNAi activity), provide unique advantages for these moieties as multi-targeted inhibitory drugs. Many such applications have demonstrated significant benefit compared with single gene-targeted siRNA inhibitors. In this article, we will review the current status of using a multi-targeted siRNA cocktail for novel therapeutic development in the treatment of cancer and viral infections. We will also propose the characteristics of various types of siRNA cocktails and their design, while recognizing the potential future impact of and challenges facing this unique therapeutic modality.
authors.affiliation: Sirnaomics, Inc., 401 Professional Drive, Suite 130, Gaithersburg, MD 20879, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ge
authors.forename: John J
authors.initials: JJ
authors.lastname: Xu
authors.forename: David M
authors.initials: DM
authors.lastname: Evans
authors.forename: A James
authors.initials: AJ
authors.lastname: Mixson
authors.forename: Harry Y
authors.initials: HY
authors.lastname: Yang
authors.forename: Patrick Y
authors.initials: PY
authors.lastname: Lu
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000627:therapeutic use*; D014777:Virus Diseases / Q000235:genetics / Q000628:therapy
chemical_list: D034741:RNA, Small Interfering