title: [Antiviral activity of aqueous extracts and polysaccharide fractions from mycelium and fruit bodies of higher fungi].
abstract: Sixty preparations of basidiomycetes (Ganoderma, Lentinus, Pleurotus, Laetiporus, Polyporus, Inonotus, Flammulina, Grifola, Trametes) were investigated with respect to their toxicity for Vero cells and antiviral activity. The antiviral activity was estimated with the use of the West Nile virus and type 2 Herpes simplex. It was shown that 11 preparations of Ganoderma, Lentinus and Pleurotus completely inhibited the infective activity in doses not lower than 1000 TCD50 (the West Nile virus) and 100 PPU (type 2 Herpes simplex). The antiviral activity of the preparations was likely due to the content of polysaccharides or their derivatives in the composition. It increased with increasing of the quantity of the total polysaccharide fraction or its concentration.
authors.forename: I A
authors.initials: IA
authors.lastname: Razumov
authors.forename: T A
authors.initials: TA
authors.lastname: Kosogova
authors.forename: E I
authors.initials: EI
authors.lastname: Kazachinskaia
authors.forename: L I
authors.initials: LI
authors.lastname: Puchkova
authors.forename: N S
authors.initials: NS
authors.lastname: Shcherbakova
authors.forename: I A
authors.initials: IA
authors.lastname: Gorbunova
authors.forename: I N
authors.initials: IN
authors.lastname: Mikhaĭlovskaia
authors.forename: V B
authors.initials: VB
authors.lastname: Loktev
authors.forename: T V
authors.initials: TV
authors.lastname: Tepliakova
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D001688:Biological Products / Q000494:pharmacology* / Q000633:toxicity; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000254:growth & development; D025282:Mycelium / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells; D019562:Viral Load / Q000187:drug effects; D014902:West Nile virus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000998:Antiviral Agents; D001688:Biological Products; D011134:Polysaccharides