title: Investigating spectrum of biological activity of 4- and 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides.
abstract: In this study, a series of twenty-two 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides and ten 4-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides is described. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against mycobacterial, bacterial and fungal strains. They were also evaluated for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The compounds showed biological activity comparable with or higher than the standards isoniazid, fluconazole, penicillin G or ciprofloxacin. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds as well as their structure-activity relationships are discussed.
authors.affiliation: Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic. ales.imramovsky@upce.cz
authors.forename: Ales
authors.initials: A
authors.lastname: Imramovsky
authors.forename: Matus
authors.initials: M
authors.lastname: Pesko
authors.forename: Katarina
authors.initials: K
authors.lastname: Kralova
authors.forename: Marcela
authors.initials: M
authors.lastname: Vejsova
authors.forename: Jirina
authors.initials: J
authors.lastname: Stolarikova
authors.forename: Jarmila
authors.initials: J
authors.lastname: Vinsova
authors.forename: Josef
authors.initials: J
authors.lastname: Jampilek
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004579:Electron Transport; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001549:Benzamides