title: [Effect of non-surgical periodontal therapy on glycemic control and the level of serum IL-6 in type 2 diabetic patients with chronic periodontitis].
abstract: OBJECTIVE
  To evaluate the effect of non-surgical periodontal therapy on periodontal status, glycemic control and the level of serum interleukin (IL)-6 in type 2 diabetic patients with chronic periodontitis (DMCP).
  
  
  METHODS
  Fifty-five DMCP and 55 systemically healthy patients with chronic periodontitis (CP) were recruited in this study. The diabetes were classified into two groups, the well-controlled group [glycated hemoglobin (HbA1c) < 7.00%] and the poorly controlled group (HbA1c ≥ 7.00%). All subjects received non-surgical periodontal therapy. Periodontal clinical parameters including periodontal probing depth(PD), attachment loss (AL), bleeding index (BI) and plaque index (PLI) were recorded at baseline, 6 weeks and 3 months after the treatment. Fasting plasma glucose (FPG), HbA1c and the concentration of serum IL-6 were measured.
  
  
  RESULTS
  At 6 weeks and 3 months after treatment, PD, AL, BI, PLI and the concentration of serum IL-6 of both groups significantly reduced (P < 0.05). The level of IL-6 in diabetic patients reduced significantly from (3.47 ± 0.33) ng/L to (3.21 ± 0.66) ng/L and to(3.03 ± 0.54) ng/L. The HbA1c of diabetic patients reduced significantly 3 months after treatment [(6.80 ± 1.21%] compared with the baseline [(7.35 ± 1.73)%, P < 0.05]. HbA1c of the poorly controlled group reduced significantly (P < 0.05), while HbA1c of the well-controlled diabetes did not show any apparent reduction (P > 0.05).
  
  
  CONCLUSIONS
  Non-surgical periodontal therapy can effectively reduce the concentration of serum IL-6, thereby improving glycemic control in type 2 diabetes patients with chronic periodontitis. However, there was no any significant reduction of HbA1c in the well-controlled diabetes.
authors.affiliation: Department of Periodontology, School of Stomatology, China Medical University, Shenyang 110002, China.
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Wei
authors.forename: Chun-rong
authors.initials: CR
authors.lastname: Chang
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Pan
authors.forename: Ning
authors.initials: N
authors.lastname: Yu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D055113:Chronic Periodontitis / Q000097:blood* / Q000150:complications / Q000628:therapy; D003774:Dental Plaque Index; D012534:Dental Scaling; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss; D010512:Periodontal Index; D011795:Surveys and Questionnaires; D014099:Toothbrushing
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D015850:Interleukin-6