title: The Hammersmith hospital hematopathology case of the month: hemophagocytic lymphohistiocytosis secondary to Epstein-Barr virus associated T-cell lymphoma.
abstract: We discuss the clinical presentation, investigations carried out, and the management issues in an elderly patient with hemophagocytic lymphohistiocytosis (HLH). The HLH was associated with an underlying Epstein-Barr virus positive peripheral T-cell lymphoma, not otherwise specified, and the lymphomatous cells harbored translocation t(5;9)(q11.2:p24). The 9p24 region contains the JAK2 gene. The disease had a fulminant course.
authors.affiliation: Department of Haematology, Hammersmith Hospital Campus, Imperial College Healthcare NHS Trust, London, UK.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Krishna
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Byrne
authors.forename: Janine
authors.initials: J
authors.lastname: Burbridge
authors.forename: Nina
authors.initials: N
authors.lastname: Salooja
authors.forename: Kikkeri N
authors.initials: KN
authors.lastname: Naresh
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000276:immunology; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis* / Q000821:virology; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology; D006761:Hospitals; D006801:Humans; D017403:In Situ Hybridization; D053614:Janus Kinase 2 / Q000235:genetics; D008131:London; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000209:etiology; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D012367:RNA, Viral / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D000914:Antibodies, Viral; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral; C507924:JAK2 protein, human; D053614:Janus Kinase 2