title: [The clinicopathological analysis of 88 patients with abnormal liver function test of unknown etiology].
abstract: OBJECTIVE
  To evaluate the clinical and histological features of patients with abnormal liver tests of unknown etiology, and then to investigate the diagnosis and differential diagnosis.
  
  
  METHODS
  Patients with abnormal liver function test hospitalized and had liver biopsies during 2008 - 2009 constituted this retrospective study cohort. After excluding those patients diagnosed with hepatotropic viral hepatitis, space occupying lesions of the liver, alcoholic liver disease and obstruction of bile duct caused by stone or malignancy and AMA/AMA-M(2) positive of primary biliary cirrhosis (PBC), the clinical and histological characteristics were evaluated.
  
  
  RESULTS
  Out of the 180 patients who underwent liver biopsy, 88 patients were included in the present analysis. The final diagnosis involved 15 categories of diseases, with drug-induced liver injury (DILI) [34.09% (30/88)], autoimmune liver diseases [22.73% (20/88)], and nonalcoholic fatty liver disease (NAFLD) [12.50% (11/88)] being the most common causes, following by genetic and other rare diseases.
  
  
  CONCLUSIONS
  DILI, autoimmune liver disease and NAFLD were the most common causes of abnormal liver tests in these non-viral liver diseases. Some rare diseases such as hereditary metabolic liver disease also represent a considerable proportion in patients with abnormal liver function test.
authors.affiliation: Hepatopathy Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Shu-zhen
authors.initials: SZ
authors.lastname: Pang
authors.forename: Xiao-juan
authors.initials: XJ
authors.lastname: Ou
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Shi
authors.forename: Tai-ling
authors.initials: TL
authors.lastname: Wang
authors.forename: Wei-jia
authors.initials: WJ
authors.lastname: Duan
authors.forename: Ji-dong
authors.initials: JD
authors.lastname: Jia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D008108:Liver Diseases, Alcoholic / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D012189:Retrospective Studies; D055815:Young Adult