title: Feasibility of simultaneous computed tomographic colonography and fully automated bone mineral densitometry in a single examination.
abstract: OBJECTIVE
  To show the feasibility of calculating the bone mineral density (BMD) from computed tomographic colonography (CTC) scans using fully automated software.
  
  
  METHODS
  Automated BMD measurement software was developed that measures the BMD of the first and second lumbar vertebrae on computed tomography and calculates the mean of the 2 values to provide a per patient BMD estimate. The software was validated in a reference population of 17 consecutive women who underwent quantitative computed tomography and in a population of 475 women from a consecutive series of asymptomatic patients enrolled in a CTC screening trial conducted at 3 medical centers.
  
  
  RESULTS
  The mean (SD) BMD was 133.6 (34.6) mg/mL (95% confidence interval, 130.5-136.7; n = 475). In women aged 42 to 60 years (n = 316) and 61 to 79 years (n = 159), the mean (SD) BMDs were 143.1 (33.5) and 114.7 (28.3) mg/mL, respectively (P < 0.0001). Fully automated BMD measurements were reproducible for a given patient with 95% limits of agreement of -9.79 to 8.46 mg/mL for the mean difference between paired assessments on supine and prone CTC.
  
  
  CONCLUSIONS
  Osteoporosis screening can be performed simultaneously with screening for colorectal polyps.
authors.affiliation: Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences Department, National Institutes of Health Clinical Center, Bethesda, MD 20892-1182, USA. rms@nih.gov
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Summers
authors.forename: Nicolai
authors.initials: N
authors.lastname: Baecher
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yao
authors.forename: Jiamin
authors.initials: J
authors.lastname: Liu
authors.forename: Perry J
authors.initials: PJ
authors.lastname: Pickhardt
authors.forename: J Richard
authors.initials: JR
authors.lastname: Choi
authors.forename: Suvimol
authors.initials: S
authors.lastname: Hill
mesh_terms: D000328:Adult; D000368:Aged; D001185:Artificial Intelligence; D015519:Bone Density; D023881:Colonography, Computed Tomographic / Q000706:statistics & numerical data*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology; D015897:Comorbidity; D003720:Densitometry / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D015995:Prevalence; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013122:Spinal Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D014481:United States / Q000453:epidemiology