title: Chemical composition and antibacterial activity of the essential oil of Drimys granadensis L.f. leaves from Colombia.
abstract: Drimys granadensis L.f., a native plant from Colombia, has been included in the Vademecum de Plantas Medicinales de Colombia by the Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, due to its widespread use in the folk medicine for the treatment of gastrointestinal ailments. The chemical composition of the essential oil of Drimys granadensis obtained by hydrodistillation of the leaves was analyzed by GC and GC/MS analyses. A total of 85 components were identified, with the major compounds germacrene D (1, 14.7%), sclarene (9.5%), a-cadinol (7.3%), longiborneol acetate (2, 6.3%), drimenol (4.2%), (Z)-β-ocimene (3, 4.2%), a-pinene (4, 3.2%), and β-elemene (5, 2.7%). The essential oil was also tested against eight bacteria using the Kirby-Bauer disk-diffusion method. Most of the Gram-positive bacteria tested were susceptible to the D. granadensis essential oil, while the Gram-negative bacteria tested were not.
authors.affiliation: Laboratorio de Botánica y Sistemática, Departamento de Ciencias Biológicas, Universidad de Andes, Apartado Aéreo 4976, Bogotá DC, Colombia.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Gaviria
authors.forename: Clara
authors.initials: C
authors.lastname: Quijano
authors.forename: Jorge
authors.initials: J
authors.lastname: Pino
authors.forename: Santiago
authors.initials: S
authors.lastname: Madriñán
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003105:Colombia; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry* / Q000254:growth & development; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D032423:Winteraceae / Q000737:chemistry* / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile