title: Nasal polyposis: from pathogenesis to treatment, an update.
abstract: Nasal polyps (NP) are common benign degeneration of nasal sinus mucosa with a prevalence around 4% in the adult population. The causes are still uncertain but there is a strong association with allergy, infection, asthma and aspirin sensitivity. Histologically, the presence of a large quantity of extracellular fluid, mast cell degranulation and eosinophilia has been demonstrated. Typically the patients show nasal obstruction, anosmia and rhinorrhoea. Nasal endoscopic examination and CT imaging allow evaluation of the disease extension. A combined medical and surgical treatment is recommended for symptoms control in preventing symptomatic NP recurrence. We will review the current knowledge in the pathogenesis and treatment of this complex disease entity.
authors.affiliation: Area of Otolaryngology, Campus Bio-Medico University, Via Alvaro del Portillo 21, 00128 Rome, Italy. m.casale@unicampus.it
authors.forename: Manuele
authors.initials: M
authors.lastname: Casale
authors.forename: Marco
authors.initials: M
authors.lastname: Pappacena
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Potena
authors.forename: Emanuela
authors.initials: E
authors.lastname: Vesperini
authors.forename: Giacomo
authors.initials: G
authors.lastname: Ciglia
authors.forename: Ranko
authors.initials: R
authors.lastname: Mladina
authors.forename: Caterina
authors.initials: C
authors.lastname: Dianzani
authors.forename: Anna Marta
authors.initials: AM
authors.lastname: Degener
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Salvinelli
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D015550:Cell Degranulation; D003131:Combined Modality Therapy; D004802:Eosinophilia; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D007239:Infections / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D008407:Mast Cells / Q000276:immunology*; D009297:Nasal Mucosa / Q000473:pathology* / Q000601:surgery; D015508:Nasal Obstruction; D009298:Nasal Polyps / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D012220:Rhinitis; D012852:Sinusitis
chemical_list: D000305:Adrenal Cortex Hormones; D006633:Histamine Antagonists