title: Membrane proteases and tetraspanins.
abstract: TEMs (tetraspanin-enriched microdomains) are specialized platforms in the plasma membrane that include adhesion receptors and enzymes. Insertion into TEMs dictates the local concentration of these molecules, regulates their internalization rate, their interaction and cross-talk with other receptors at the plasma membrane and provides links with certain signalling pathways. We focus on the associations described for tetraspanins with membrane proteases and their substrates, reviewing the emerging evidence in the literature that suggests that TEMs might be essential platforms for regulating protein shedding, RIP (regulated intramembrane proteolysis) and matrix degradation and assembly.
authors.affiliation: Servicio de Inmunología, Hospital de la Princesa, Instituto de Investigación Sanitaria Princesa (IP), Madrid, Spain. myanez.hlpr@salud.madrid.org
authors.forename: María
authors.initials: M
authors.lastname: Yáñez-Mó
authors.forename: Francisco
authors.initials: F
authors.lastname: Sánchez-Madrid
authors.forename: Carlos
authors.initials: C
authors.lastname: Cabañas
mesh_terms: D051722:ADAM Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D053829:Amyloid Precursor Protein Secretases / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D015703:Antigens, CD; D008565:Membrane Proteins; D053829:Amyloid Precursor Protein Secretases; D010447:Peptide Hydrolases; D051722:ADAM Proteins; D020782:Matrix Metalloproteinases