title: Monoalkylglycerol ether lipids promote adipogenesis.
abstract: The molecular mechanisms that lead to the generation of adipose tissue (adipogenesis) are of basic and biomedical interest. Cellular models of adipogenesis have proven extremely valuable in defining biomolecules-primarily genes and proteins-that regulate adipogenesis. Here, the analysis of differentiating adipocytes using an untargeted metabolomics approach led to the discovery of the monoalkylglycerol ethers as a natural class of adipocyte differentiation factors.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: Edwin A
authors.initials: EA
authors.lastname: Homan
authors.forename: Yun-Gon
authors.initials: YG
authors.lastname: Kim
authors.forename: James P
authors.initials: JP
authors.lastname: Cardia
authors.forename: Alan
authors.initials: A
authors.lastname: Saghatelian
mesh_terms: D041721:3T3-L1 Cells; D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects; D005990:Glycerol / Q000737:chemistry / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D055432:Metabolomics; D051379:Mice
chemical_list: D005990:Glycerol