title: Effect of preparation route on the degradation behavior and ion releasability of siloxane-poly(lactic acid)-vaterite hybrid nonwoven fabrics for guided bone regeneration.
abstract: Two types of nonwoven fabric, consisting of siloxane-doped vaterite (SiV) and poly(lactic acid) (PLA), for guided bone regeneration (GBR) were prepared by an electrospinning. One of the fabrics, SiV-PLA(M), was derived from PLA mixed with the solution of SiV dispersed in chloroform. Another one, SiV-PLA(K), was derived from a composite prepared by kneading SiV and PLA while heating at 200°C. The SiV-PLA(K) fabric shows higher degradability in dilute NaOH aq. than the SiV-PLA(M) fabric. To improve the cellular compatibility of the fabric, the fibers were coated with hydroxyapatite (HA) by soaking in simulated body fluid. The HA-coated SiV-PLA(K) fabric showed the release of silicate ions; the amount was reduced by 1/5 to 1/8 compared with that of the HA-coated SiV-PLA(M) fabric, and the excessive release was controlled. The preparation route of kneading at 200°C led to formation of a fabric with degradation behavior and ion releasability effective for bone regeneration.
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Wakita
authors.forename: Jin
authors.initials: J
authors.lastname: Nakamura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ota
authors.forename: Akiko
authors.initials: A
authors.lastname: Obata
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kasuga
authors.forename: Seiji
authors.initials: S
authors.lastname: Ban
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D002119:Calcium Carbonate / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002725:Chloroform / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003461:Crystallography; D004058:Diffusion; D017886:Durapatite / Q000737:chemistry; D055664:Electrochemical Techniques; D005404:Fixatives / Q000737:chemistry; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D006358:Hot Temperature; D006801:Humans; D006868:Hydrolysis; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D017640:Silicates / Q000737:chemistry; D012833:Siloxanes / Q000737:chemistry*; D012972:Sodium Hydroxide / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D005404:Fixatives; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D017640:Silicates; D012833:Siloxanes; D019344:Lactic Acid; C033616:poly(lactide); D012972:Sodium Hydroxide; D002725:Chloroform; D017886:Durapatite; D002119:Calcium Carbonate; D002118:Calcium