title: The probability analysis of opening of DNA.
abstract: We have studied the separation of a double stranded DNA (dsDNA), which is driven by either the temperature or force. By monitoring the probability of opening of entire base pairs along the chain, we show that the opening of a dsDNA depends not only on the sequence but also on the constraints on the chain in the experimental setups. Our results clearly demonstrate that the force-induced melting of dsDNA, whose one of the ends is constrained, is significantly different from the thermal melting, when both ends are free.
authors.affiliation: Department of Physics, Banaras Hindu University, Varanasi 221 005, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Srivastava
authors.forename: Navin
authors.initials: N
authors.lastname: Singh
mesh_terms: D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D011336:Probability; D013696:Temperature
chemical_list: D004247:DNA