title: Thermal denaturation of DNA studied with neutron scattering.
abstract: The melting transition of DNA, whereby the strands of the double-helix structure completely separate at a certain temperature, has been characterized using neutron scattering. A Bragg peak from B-form fiber DNA has been measured as a function of temperature, and its widths and integrated intensities have been interpreted using the Peyrard-Bishop-Dauxois model with only one free parameter. The experiment is unique, as it gives spatial correlation along the molecule through the melting transition where other techniques cannot.
authors.affiliation: Institut Laue Langevin, Grenoble, France.
authors.forename: Andrew
authors.initials: A
authors.lastname: Wildes
authors.forename: Nikos
authors.initials: N
authors.lastname: Theodorakopoulos
authors.forename: Jessica
authors.initials: J
authors.lastname: Valle-Orero
authors.forename: Santiago
authors.initials: S
authors.lastname: Cuesta-López
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Garden
authors.forename: Michel
authors.initials: M
authors.lastname: Peyrard
mesh_terms: D004247:DNA / Q000737:chemistry*; D033363:Neutron Diffraction; D009691:Nucleic Acid Denaturation; D044366:Transition Temperature
chemical_list: D004247:DNA