title: Cigarette smoke inhibits brain mitochondrial adaptations of exercised mice.
abstract: Physical exercise and smoking are environmental factors that generally cause opposite health-promoting adaptations. Both physical exercise and smoking converge on mitochondrial adaptations in various tissues, including the pro-oxidant nervous system. Here, we analyzed the impact of cigarette smoking on exercise-induced brain mitochondrial adaptations in the hippocampus and pre-frontal cortex of adult mice. The animals were exposed to chronic cigarette smoke followed by 8 weeks of moderate-intensity physical exercise that increased mitochondrial activity in the hippocampus and pre-frontal cortex in the non-smoker mice. However, mice previously exposed to cigarette smoke did not present these exercise-induced mitochondrial adaptations. Our results suggest that smoking can inhibit some brain health-promoting changes induced by physical exercise.
authors.affiliation: Laboratório Experimental de Doenças Neurodegenerativas, Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC 88049-900, Brazil.
authors.forename: Ana Elisa
authors.initials: AE
authors.lastname: Speck
authors.forename: Daiane
authors.initials: D
authors.lastname: Fraga
authors.forename: Priscila
authors.initials: P
authors.lastname: Soares
authors.forename: Débora L
authors.initials: DL
authors.lastname: Scheffer
authors.forename: Luciano A
authors.initials: LA
authors.lastname: Silva
authors.forename: Aderbal S
authors.initials: AS
authors.lastname: Aguiar
authors.forename: Emílio L
authors.initials: EL
authors.lastname: Estreck
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Pinho
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D051379:Mice; D008928:Mitochondria / Q000502:physiology*; D010805:Physical Conditioning, Animal; D012906:Smoke; D014026:Nicotiana
chemical_list: D012906:Smoke