title: Ligands for copper-catalyzed C-N bond forming reactions with 1 mol% CuBr as catalyst.
abstract: Several new ligands were designed to promote copper-catalyzed Ullman C-N coupling reactions. In this group, 8-hydroxyquinolin-N-oxide was found to serve as a superior ligand for CuBr-catalyzed coupling reactions of aryl iodides, bromides, and chlorides with aliphatic amines and N-heterocycles under a low catalyst loading (1% [Cu] mol). Reactions with the inexpensive catalytic system display a high functional group tolerance as well as excellent chemoselectivity.
authors.affiliation: Laboratory of Regenerative Biology, Guangzhou, Institute of Biomedicine and Health, CAS, Guangzhou, 510663, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.forename: Yatao
authors.initials: Y
authors.lastname: Qiu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Wang
authors.forename: Sheng
authors.initials: S
authors.lastname: Jiang
mesh_terms: D001965:Bromides / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D009584:Nitrogen / Q000737:chemistry*
chemical_list: D001965:Bromides; D008024:Ligands; C408079:cupric bromide; D002244:Carbon; D003300:Copper; D009584:Nitrogen