title: Three new constituents from the roots of Erythrina variegata and their antibacterial activity against methicillin-resistant Staphylococcus aureus.
abstract: Two new isoflavonoids, eryvarins V and W (1 and 2, resp.), and a new chromen-4-one derivative, eryvarin X (3), along with three known isoflavonoids, 4-6, were isolated from the roots of Erythrina variegata. Their structures were established by spectroscopic analyses. Compound 1 is a rare naturally occurring isoflavanone which possesses a OH group at C(3). Among the new compounds 1-3, 2 exhibited a potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains.
authors.affiliation: Faculty of Pharmacy, Meijo University, Yagoto, Tempaku-ku, Nagoya 468-8503, Japan. hitoshi@ccmfs.meijo-u.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Ikunori
authors.initials: I
authors.lastname: Atsumi
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirota
authors.forename: Setsuko
authors.initials: S
authors.lastname: Sekita
authors.forename: Eiji
authors.initials: E
authors.lastname: Sakai
authors.forename: Masaru
authors.initials: M
authors.lastname: Sato
authors.forename: Jin
authors.initials: J
authors.lastname: Murata
authors.forename: Hiroko
authors.initials: H
authors.lastname: Murata
authors.forename: Dedy
authors.initials: D
authors.lastname: Darnaedi
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004895:Erythrina / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002867:Chromones; D007529:Isoflavones; C569725:eryvarin V; C569726:eryvarin W; C569724:eryvarin X