title: Hematopoietic stromal cells and megakaryocyte development.
abstract: The hematopoietic microenvironment, and in particular the hematopoietic stromal cell element, are intimately involved in megakaryocyte development. The process of megakaryocytopoiesis occurs within a complex bone marrow microenvironment where adhesive interactions, chemokines, as well as cytokines play a pivotal role. Here we review the effect of stromal cells and cytokines on megakaryocytopoiesis with the aim of exploring new therapeutic strategies for platelet recovery after hematopoietic stem cell transplantation (HSCT).
authors.affiliation: Department of Hematology, Second Affiliated Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Yimei
authors.initials: Y
authors.lastname: Feng
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.forename: Xinghua
authors.initials: X
authors.lastname: Chen
mesh_terms: D001854:Bone Marrow Cells / Q000166:cytology*; D015815:Cell Adhesion Molecules; D016207:Cytokines / Q000502:physiology*; D005312:Fetal Blood / Q000166:cytology; D018380:Hematopoietic Stem Cell Transplantation; D006413:Hematopoietic System / Q000166:cytology*; D006801:Humans; D017713:Platelet Transfusion; D017154:Stromal Cells; D034061:Thrombopoiesis / Q000502:physiology*
chemical_list: D015815:Cell Adhesion Molecules; D016207:Cytokines