title: Impact of glycemic control on the clinical outcome in diabetic patients with percutaneous coronary intervention--from the FU-registry.
abstract: BACKGROUND
  It is not yet clear whether glycemic control affects the clinical outcome of percutaneous coronary intervention (PCI) in diabetic patients.
  
  
  RESULTS
  This study compared the effects of glycemic control on the clinical outcome in 2 groups of patients with diabetes mellitus (DM) who underwent PCI: a poor-glycemic-control group, who showed greater than 6.9% HbA(1c) at the time of PCI (Pre-HbA(1c)) (`≥6.9 group', n=334 patients) and a good-glycemic-control group, who showed less than <6.9% at Pre-HbA(1c) (`<6.9 group', n=212 patients). The patients in the ≥6.9 group were further divided into 2 groups for further comparisons: a `DM control group' and a `Poor control group'. At follow-up (300 days), the incidence of major adverse cardiac event (MACE) was significantly (P<0.05) lower in the <6.9 group (18.4% vs. 26.2%). However, there was no difference in MACE between the DM control group and the Poor control group. In a multivariate analysis, there was no relationship between the incidence of MACE and Pre-HbA(1c), Pre-HbA(1c)≥6.9% or the HbA(1c) difference (Pre-HbA(1c)-HbA(1c) at follow-up).
  
  
  CONCLUSIONS
  Clinical outcomes in the <6.9 group were superior to those in the ≥6.9 group as pre-PCI glycemic control affected the baseline characteristics. The results suggested that glycemic control started at PCI was not associated with an improvement in the clinical outcome at follow-up.
authors.affiliation: Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Amane
authors.initials: A
authors.lastname: Ike
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shirai
authors.forename: Ken
authors.initials: K
authors.lastname: Mori
authors.forename: Takashi
authors.initials: T
authors.lastname: Kuwano
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Takamiya
authors.forename: Daizaburo
authors.initials: D
authors.lastname: Yanagi
authors.forename: Kazumitsu
authors.initials: K
authors.lastname: Kubota
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tsuchiya
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Miura
authors.forename: Keijiro
authors.initials: K
authors.lastname: Saku
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001786:Blood Glucose; D003925:Diabetic Angiopathies / Q000097:blood / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis / Q000378:metabolism; D038321:Glycemic Index; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human