title: Recent advances in the field of nanometric drug carriers.
abstract: Over the past few years, health and medicine have been domains where nanotechnologies have shown great promise, in particular in the area of drug carriers and drug targeting. Many active substances suffer from poor solubility, instability in biological medium and low bioavailability. Inaccurate distribution and accumulation of the drug in the body could lead to some side effects possibly detrimental to drug development. With the advent of nanosciences applied to medicine, new tools are becoming available, giving rise to a whole range of drug carriers with different properties and functionalities. Nanocarriers should play a crucial role in the controlled and sustained delivery of drugs. Various types of functional nanosystems are currently being explored and the aim of this review is to give an overview of the most recent advances in the field of nanometric drug carriers, including future strategies and perspectives.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191 Gif-sur-Yvette, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Ogier
authors.forename: Thomas
authors.initials: T
authors.lastname: Arnauld
authors.forename: Eric
authors.initials: E
authors.lastname: Doris
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D001672:Biocompatible Materials / Q000737:chemistry; D002986:Clinical Trials as Topic; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D001672:Biocompatible Materials; D004337:Drug Carriers; D011092:Polyethylene Glycols; D004317:Doxorubicin