title: An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: the influence of colloidal structure on emulsions skin hydration potential.
abstract: To be considered as a suitable vehicle for drugs/cosmetic actives, an emulsion system should have a number of desirable properties mainly dependent on surfactant used for its stabilization. In the current study, C(12-14) alkyl polyglucoside (APG)-mixed emulsifier of natural origin has been investigated in a series of binary (emulsifier concentration 10-25% (w/w)) and ternary systems with fixed emulsifier content (15% (w/w)) with or without glycerol. To elucidate the systems' colloidal structure the following physicochemical techniques were employed: polarization and transmission electron microscopy, X-ray diffraction (WAXD and SAXD), thermal analysis (DSC and TGA), complex rheological, pH, and conductivity measurements. Additionally, the emulsion vehicles' skin hydration potential was tested in vivo, on human skin under occlusion. In a series of binary systems with fixed emulsifier/water ratios ranging from 10/90 to 25/75 the predominance of a lamellar mesophase was found, changing its character from a liquid crystalline to a gel crystalline type. The same was observed in gel emulsions containing equal amounts of emulsifier and oil (15% (w/w)), but varying in glycerol content (0-25%). Different emulsion samples exhibited different water distribution modes in the structure, reflecting their rheological behavior and also their skin hydration capacity.
authors.affiliation: Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. snexs@pharmacy.bg.ac.rs
authors.forename: Snezana
authors.initials: S
authors.lastname: Savic
authors.forename: Milica
authors.initials: M
authors.lastname: Lukic
authors.forename: Ivana
authors.initials: I
authors.lastname: Jaksic
authors.forename: Stephan
authors.initials: S
authors.lastname: Reichl
authors.forename: Slobodanka
authors.initials: S
authors.lastname: Tamburic
authors.forename: Christel
authors.initials: C
authors.lastname: Müller-Goymann
mesh_terms: D002152:Calorimetry, Differential Scanning; D003102:Colloids / Q000737:chemistry / Q000378:metabolism; D045703:Emulsifying Agents / Q000737:chemistry / Q000378:metabolism*; D004655:Emulsions / Q000737:chemistry / Q000378:metabolism; D005960:Glucosides / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D012212:Rheology; D012867:Skin / Q000378:metabolism*; D014867:Water / Q000378:metabolism*; D014961:X-Ray Diffraction
chemical_list: D003102:Colloids; D045703:Emulsifying Agents; D004655:Emulsions; D005960:Glucosides; D014867:Water