title: Haematological interventions for treating disseminated intravascular coagulation during pregnancy and postpartum.
abstract: BACKGROUND
  Disseminated intravascular coagulation (DIC) is an acquired syndrome characterised by systemic intravascular activation of coagulation. There are several obstetric causes of DIC during pregnancy and postpartum.
  
  
  OBJECTIVE
  To assess the clinical effectiveness and safety of haematological interventions such as heparins (low molecular weight heparin (LMWH) and unfractionated heparin (UFH), danaparoid sodium, synthetic protease inhibitor, antithrombin, human recombinant activated protein C, recombinant human soluble thrombomodulin, recombinant tissue factor pathway inhibitor, recombinant activated factor VIIa and any other types of haematological interventions (except transfusions) for treating DIC during pregnancy and postpartum.
  
  
  METHODS
  We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (27 July 2010), LILACS (1982 to 22 July 2010), ongoing trials registries via the World Health Organization International Clinical Trials Platform Search Portal (22 July 2010), and other relevant websites (22 July 2010).
  
  
  METHODS
  Randomised controlled trials (RCTs) on any haematological interventions for treating DIC during pregnancy and postpartum.
  
  
  METHODS
  There were no included studies.
  
  
  RESULTS
  We could not find any RCTs on haematological interventions (heparins (LMWH and UFH), danaparoid sodium, synthetic protease inhibitor, antithrombin, human recombinant activated protein C, recombinant human soluble thrombomodulin, recombinant tissue factor pathway inhibitor, recombinant activated factor VIIa and any other types of haematological interventions) for treating DIC during pregnancy and postpartum.
  
  
  CONCLUSIONS
  This review found no RCTs on the safety and efficacy of haematological interventions for treating DIC during pregnancy and postpartum. Such interventions need to be tested in RCTs assessing outcomes such as maternal death, perinatal death and safety.
authors.affiliation: Iberoamerican Cochrane Network, Valencia, Edo. Carabobo, Venezuela, 2001.
authors.forename: Arturo J
authors.initials: AJ
authors.lastname: Martí-Carvajal
authors.forename: Gabriella
authors.initials: G
authors.lastname: Comunián-Carrasco
authors.forename: Guiomar E
authors.initials: GE
authors.lastname: Peña-Martí
mesh_terms: D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D005260:Female; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*