title: Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity.
abstract: The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.
authors.affiliation: Division of Infectious Disease, Weill Cornell Medical College, New York, New York 10011, USA. tiw2001@med.cornell.edu
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Wilkin
authors.forename: Mathew Bidwell
authors.initials: MB
authors.lastname: Goetz
authors.forename: Robert
authors.initials: R
authors.lastname: Leduc
authors.forename: Gail
authors.initials: G
authors.lastname: Skowron
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Su
authors.forename: Ellen S
authors.initials: ES
authors.lastname: Chan
authors.forename: Jayyant
authors.initials: J
authors.lastname: Heera
authors.forename: Doug
authors.initials: D
authors.lastname: Chapman
authors.forename: John
authors.initials: J
authors.lastname: Spritzler
authors.forename: Jacqueline D
authors.initials: JD
authors.lastname: Reeves
authors.forename: Roy M
authors.initials: RM
authors.lastname: Gulick
authors.forename: Eoin
authors.initials: E
authors.lastname: Coakley
mesh_terms: D000328:Adult; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D019713:Receptors, CCR5 / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000378:metabolism; D015728:Receptors, HIV / Q000378:metabolism*; D056189:Viral Tropism; D014773:Virology / Q000379:methods*; D053585:Virus Attachment
chemical_list: C527276:CXCR4 protein, human; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D015728:Receptors, HIV