title: Triterpene and sterol derivatives from the roots of Breynia fruticosa.
abstract: A new nor-ceanothane-type triterpenoid, breynceanothanolic acid (1), and seven novel 4α-methyl sterols, fruticosides A-G (2-8), were obtained from the roots of Breynia fruticosa. The new compound structures were established by means of extensive spectroscopic and chemical methods. Compounds 7 and 8 are sulfur-containing derivatives of the 4α-methyl sterols, and the sugar moiety of compounds 4, 5, 7, and 8 (L-quinovose) is uncommon in plants. Compounds 1 and 2 exhibited moderate cytotoxicity against five human cancer cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Liu
authors.forename: Xiang-Hai
authors.initials: XH
authors.lastname: Cai
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Li
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Luo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D013261:Sterols; D014315:Triterpenes; C560142:breynceanothanolic acid; C549430:ceanothane