title: [Effects of Shengmai injection on testicular injury after torsion/detorsion in rats of different ages].
abstract: OBJECTIVE
  To investigate the different effects of Shengmai injection on testicular injury after testis torsion/detorsion in rats of different ages.
  
  
  METHODS
  Sixteen healthy male SD rats aged 3, 6 and 12 weeks were equally randomized into an experimental group (testicular torsion/detorsion plus Shengmai injection) and a control group (testicular torsion/detorsion plus saline). The rat models of testicular torsion were killed 24 h after surgery for the measurement of total antioxidant capacity (T-AOC), superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the testis.
  
  
  RESULTS
  Compared with the controls, the 3- and 6-week-old rats of the experimental group showed no significant changes in T-AOC, SOD activity and MDA content (P > 0.05), while the 12-week-old experimental rats exhibited a remarkable increase in SOD and T-AOC and an obvious decrease in MDA content (P < 0.05).
  
  
  CONCLUSIONS
  Shengmai injection has a protective effect against acute ischemia-reperfusion testicular injury after torsion/detorsion in rats, but the effect varies with the age, more obvious in older ones.
authors.affiliation: School of Clinical Medicine, Shaoxing University Medical College, Shaoxing, Zhejiang 312000, China. 195zyf@163.com
authors.forename: Yi-fu
authors.initials: YF
authors.lastname: Zhou
authors.forename: Chun-chao
authors.initials: CC
authors.lastname: Ni
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Zheng
authors.forename: Nai-jing
authors.initials: NJ
authors.lastname: Xu
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Yu
authors.forename: Jin-ping
authors.initials: JP
authors.lastname: Zhang
authors.forename: Gui-shan
authors.initials: GS
authors.lastname: Gao
mesh_terms: D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control; D013086:Spermatic Cord Torsion / Q000188:drug therapy* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination; D008315:Malondialdehyde; D013482:Superoxide Dismutase