title: Antioxidant and antiglycating activities of Salvia sahendica and its protective effect against oxidative stress in neuron-like PC12 cells.
abstract: Increased oxidative stress is widely accepted to be a factor in the development and progression of Alzheimer's disease (AD). Here we introduced Salvia sahendica as a protective agent in differentiated PC12 cells, which are commonly considered to be a reliable model of neuronal cells. Our results demonstrated that S. sahendica has antioxidant and antiglycating properties in in vitro system and these properties are expanded into H(2)O(2)-induced model. S. sahendica inhibited H(2)O(2)-induced cell death in PC12 cells. We further showed that this plant exerts its protective effect by increasing superoxide dismutase and catalase levels, reducing lipid peroxidation and upregulating hemoxygenase-1 and glutamylcysteine synthetase proteins. This study raises the possibility of developing S. sahendica as a potential neuroprotective agent.
authors.affiliation: Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Shaerzadeh
authors.forename: Abolhassan
authors.initials: A
authors.lastname: Ahmadiani
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Esmaeili
authors.forename: Niloufar
authors.initials: N
authors.lastname: Ansari
authors.forename: Sareh
authors.initials: S
authors.lastname: Asadi
authors.forename: Solaleh Khoramian
authors.initials: SK
authors.lastname: Tusi
authors.forename: Ali
authors.initials: A
authors.lastname: Sonboli
authors.forename: Mina
authors.initials: M
authors.lastname: Ghahremanzamaneh
authors.forename: Fariba
authors.initials: F
authors.lastname: Khodagholi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D016716:PC12 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D027544:Salvia / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase