title: [Successful treatment with the combination of recombinant human soluble thrombomodulin and gabexate mesilate in three patients with obstetric disseminated intravascular coagulation].
abstract: Recombinant human soluble thrombomodulin (rTM) is a new drug for the treatment of disseminated intravascular coagulation (DIC), although the effects on obstetric DIC have not yet been fully elucidated. We report herein three patients with obstetric DIC caused by placental abruption, hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and atonic bleeding, respectively. In all three cases, treatment with rTM proved successful, suggesting that rTM is an efficient method for treating obstetric DIC.
authors.affiliation: Depatment of Hematology, Seichokai Fuchu Hospital.
authors.forename: Takeo
authors.initials: T
authors.lastname: Kumura
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Aoyama
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Ichihara
authors.forename: Shirou
authors.initials: S
authors.lastname: Koh
authors.forename: Atuko
authors.initials: A
authors.lastname: Mugitani
authors.forename: Hitomi
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yukioka
authors.forename: Dan
authors.initials: D
authors.lastname: Kinoshita
authors.forename: Masako
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yamazaki
mesh_terms: D000037:Abruptio Placentae; D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D005260:Female; D016670:Gabexate / Q000008:administration & dosage*; D017359:HELLP Syndrome; D006461:Hemolysis; D006801:Humans; D011247:Pregnancy; D011994:Recombinant Proteins / Q000008:administration & dosage; D012995:Solubility; D018180:Thrombomodulin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; C546931:THBD protein, human; D018180:Thrombomodulin; D016670:Gabexate