title: Pilot randomized trial for treatment of bacterial vaginosis using in situ forming metronidazole vaginal gel.
abstract: OBJECTIVE
  To compare the efficacy of a novel vaginal delivery system for metronidazole (0.8% MTZ in situ gel) versus a conventional MTZ vaginal gel product in the treatment of bacterial vaginosis (BV).
  
  
  METHODS
  All consecutive patients who presented to a tertiary care hospital with symptoms suggestive of BV were approached to participate in the study. Forty-two eligible participants were randomly assigned to either MTZ in situ gel or a conventional vaginal gel product twice daily for 5 days. All participants were re-examined after one and 4 weeks of the beginning of treatment to ensure cure of infection and any side-effects.
  
  
  RESULTS
  Demographic criteria of the participants were comparable in the two treatment groups. The cure rate after one week from the treatment was 85% in the in situ gel group and 71.4% in the conventional vaginal gel group (P = 0.294), while after 4 weeks, the cure rate showed significant difference in the in situ gel group as compared to the conventional vaginal gel group (16/20 [80%]) and (9/19 [47.4%]), respectively (P = 0.034).
  
  
  CONCLUSIONS
  Pilot testing showed that in situ MTZ vaginal gel is more effective than the conventional vaginal gel for long-term cure of BV. These findings suggest a novel and efficient long-term treatment of BV.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt. omshaaban2000@yahoo.com
authors.forename: Omar M
authors.initials: OM
authors.lastname: Shaaban
authors.forename: Gihan N
authors.initials: GN
authors.lastname: Fetih
authors.forename: Noura H
authors.initials: NH
authors.lastname: Abdellah
authors.forename: Saeyd
authors.initials: S
authors.lastname: Ismail
authors.forename: Maggie A
authors.initials: MA
authors.lastname: Ibrahim
authors.forename: El-sayed A
authors.initials: el-SA
authors.lastname: Ibrahim
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D055598:Chemical Phenomena; D016503:Drug Delivery Systems; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D010865:Pilot Projects; D014622:Vaginal Creams, Foams, and Jellies; D016585:Vaginosis, Bacterial / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D014622:Vaginal Creams, Foams, and Jellies; D008795:Metronidazole