title: Coupled Iterated Map Models of Action Potential Dynamics in a One-dimensional Cable of Cardiac Cells.
abstract: Low-dimensional iterated map models have been widely used to study action potential dynamics in isolated cardiac cells. Coupled iterated map models have also been widely used to investigate action potential propagation dynamics in one-dimensional (1D) coupled cardiac cells, however, these models are usually empirical and not carefully validated. In this study, we first developed two coupled iterated map models which are the standard forms of diffusively coupled maps and overcome the limitations of the previous models. We then determined the coupling strength and space constant by quantitatively comparing the 1D action potential duration profile from the coupled cardiac cell model described by differential equations with that of the coupled iterated map models. To further validate the coupled iterated map models, we compared the stability conditions of the spatially uniform state of the coupled iterated maps and those of the 1D ionic model and showed that the coupled iterated map model could well recapitulate the stability conditions, i.e., the spatially uniform state is stable unless the state is chaotic. Finally, we combined conduction into the developed coupled iterated map model to study the effects of coupling strength on wave stabilities and showed that the diffusive coupling between cardiac cells tends to suppress instabilities during reentry in a 1D ring and the onset of discordant alternans in a periodically paced 1D cable.
authors.affiliation: Department of Medicine (Cardiology), David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA.
authors.forename: Shihong
authors.initials: S
authors.lastname: Wang
authors.forename: Yuanfang
authors.initials: Y
authors.lastname: Xie
authors.forename: Zhilin
authors.initials: Z
authors.lastname: Qu