title: Synthesis and biological evaluation of novel acenaphthene derivatives as potential antitumor agents.
abstract: Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by ¹H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3). Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin.
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Xie
authors.forename: Yi
authors.initials: Y
authors.lastname: Deng
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Dai
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Ouyang
authors.forename: Yu-Quan
authors.initials: YQ
authors.lastname: Wei
authors.forename: Ying-Lan
authors.initials: YL
authors.lastname: Zhao
mesh_terms: D000073:Acenaphthenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000073:Acenaphthenes; D000970:Antineoplastic Agents; C042552:acenaphthene