title: [Triazavirin prophylactic efficacy against influenza virus A (H5N1)].
abstract: The experimental study of the prophylactic efficacy of Triazaverin against the experimental form of the influenza virus A (H5N1) on albino mice intranasally infected with the influenza virus A/Chicken/Kurgan/Russia/02/05 vs. the reference drugs Tamiflu, Remantadin and Arbidol showed that in doses of 1 to 100 mg/kg it was efficient in the animal protection from death. The drug was also efficient in the urgent prophylaxis. Triazaverin effectively inhibited the influenza A virus multiplication in the lungs of the albino mice.
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Loginova
authors.forename: S V
authors.initials: SV
authors.lastname: Borisevich
authors.forename: V A
authors.initials: VA
authors.lastname: Maksimov
authors.forename: V P
authors.initials: VP
authors.lastname: Bondarev
authors.forename: S K
authors.initials: SK
authors.lastname: Kotovskaia
authors.forename: V L
authors.initials: VL
authors.lastname: Rusinov
authors.forename: V N
authors.initials: VN
authors.lastname: Charushin
authors.forename: O N
authors.initials: ON
authors.lastname: Chupakhin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001393:Azoles / Q000008:administration & dosage / Q000627:therapeutic use*; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects* / Q000502:physiology; D008168:Lung / Q000821:virology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D012426:Russia; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use*; D014230:Triazoles; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001393:Azoles; D014227:Triazines; D014230:Triazoles; C539416:riamilovir