title: Influence of angular width and peripapillary position of localized retinal nerve fiber layer defects on their detection by time-domain optical coherence tomography.
abstract: OBJECTIVE
  To investigate the influence of angular width and peripapillary position of localized retinal nerve fiber layer (RNFL) defects on their detection by the time-domain optical coherence tomography (OCT).
  
  
  METHODS
  Fast RNFL Stratus OCT scans were obtained from 186 eyes of 186 newly detected glaucoma patients with only a single, localized RNFL defect in either eye. The RNFL defects were divided into subgroups according to their angular width at 15° intervals and superior or inferior position. In the sector average graph of OCT results, abnormal clock-hour sectors were evaluated at P < 5%.
  
  
  RESULTS
  Among 154 eyes included in the final data analysis, mean angular width of localized RNFL defects was 21.82 ± 10.38°, and 108 eyes (70.1%) had an inferiorly located RNFL defect. Localized RNFL defects with an angular width interval of 30° to 45° were more frequently detected by Stratus OCT than those with an angular width of <15° (odds ratio = 30.32, P = 0.001). Inferior RNFL defects were not detected more frequently by Stratus OCT than superior RNFL defects (odds ratio = 1.58, P = 0.24).
  
  
  CONCLUSIONS
  Only the angular width of localized RNFL defects had a significant influence on the sensitivity of the time-domain OCT.
authors.affiliation: Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. demian7435@gmail.com
authors.forename: Young Cheol
authors.initials: YC
authors.lastname: Yoo
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D005654:Fundus Oculi; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006068:Gonioscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D010781:Photography; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods