title: [Proton pump inhibitors and infection risk].
abstract: Gastric antisecretory drugs, especially proton pump inhibitors, are among the most used drugs both in ambulatory and hospital settings, and prescription does not always follows approved indications. Experimental data suggest that gastric acid inhibition and the effects of proton pump inhibitors on the immune system can promote the development of infections. In recent years a number of observational studies have found an independent association between the use of proton pump inhibitors and an increased risk of gastrointestinal infections, including those caused by Clostridium difficile, and community and nosocomial pneumonia. This review discusses the current evidence, raises the potential pathogenic mechanisms involved and makes recommendations for current clinical practice and future research.
authors.affiliation: Servicio de Medicina Intensiva, Hospital Infanta Leonor, Madrid, Spain. palenciah@gmail.com
authors.forename: E
authors.initials: E
authors.lastname: Palencia-Herrejón
authors.forename: B
authors.initials: B
authors.lastname: Sánchez
authors.forename: I
authors.initials: I
authors.lastname: Escobar
authors.forename: M L
authors.initials: ML
authors.lastname: Gómez-Lus
mesh_terms: D006801:Humans; D007107:Immune System / Q000187:drug effects; D007239:Infections / Q000453:epidemiology*; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D012306:Risk
chemical_list: D054328:Proton Pump Inhibitors