title: A case of successful treatment with polymyxin B-immobilized fiber column direct hemoperfusion in acute respiratory distress syndrome after influenza A infection.
abstract: We report a case of acute respiratory distress syndrome (ARDS) after influenza A infection who was successfully treated with combined treatment including direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) column. A 56-year-old Japanese man was admitted to our hospital in January 2010 because of progressive dyspnea, hypoxemia, fever and bilateral diffuse infiltration on chest radiograph after pandemic influenza A infection. His chest computed tomography showed diffuse and patchy bilateral ground-glass opacities, and we diagnosed ARDS after influenza A infection. The patient was successfully treated with PMX-DHP in addition to the treatment with oseltamivir, corticosteroid, sivelestat and antibiotics with mechanical ventilation, and the patient recovered with only minor pulmonary fibrotic change. Although the efficacy of PMX-DHP treatment in patients with acute lung injury (ALI)/ARDS after influenza virus infection is not well established, this treatment could be a possible therapeutic modality in treating the patients with this disease.
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan. yatera@med.uoeh-u.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yatera
authors.forename: Kei
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Toshinori
authors.initials: T
authors.lastname: Kawanami
authors.forename: Susumu
authors.initials: S
authors.lastname: Tokuyama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ogoshi
authors.forename: Minako
authors.initials: M
authors.lastname: Kouzaki
authors.forename: Shuya
authors.initials: S
authors.lastname: Nagata
authors.forename: Chinatsu
authors.initials: C
authors.lastname: Nishida
authors.forename: Chiharu
authors.initials: C
authors.lastname: Yoshii
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
mesh_terms: D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011112:Polymyxin B / Q000627:therapeutic use*; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D011112:Polymyxin B