title: Transfusion transmitted infections in patients with hemophilia of Karachi, Pakistan.
abstract: The aim of the study was to assess the prevalence of HCV, HBV, and HIV infections among the patients with hemophilia. Patients with Hemophilia A and B were evaluated who visited hospital for factor replacement therapy. The viral markers tested in these patients included anti-HCV-Ab, HBsAg, and anti-HIV-Ab. Seroprevalence was compared from 5717 exchange healthy blood donors for same markers. A total of 173 multitransfused male hemophiliacs showed prevalence of 51.4% for HCV, 1.73% for HBV, and nil for HIV. In blood donors seroprevalence was 1.9% for HCV, 1.81% for HBV, while no HIV-positive case was detected. Prevalence of anti-HCV-Ab was significantly high in patients with hemophilia than normal donors (P = .0005). This study showed that HCV infection was more frequently identified than HBV and HIV infections in multitransfused hemophiliacs. The frequency of hepatitis C among blood donors is also higher than that of hepatitis B which is showing downward trend.
authors.affiliation: Department of Blood Bank & Haemostasis, National Institute of Blood Disease & Bone Marrow Transplantation. drmunirashoaib@yahoo.com
authors.forename: Munira
authors.initials: M
authors.lastname: Borhany
authors.forename: Tahir
authors.initials: T
authors.lastname: Shamsi
authors.forename: Samsan
authors.initials: S
authors.lastname: Boota
authors.forename: Hazrat
authors.initials: H
authors.lastname: Ali
authors.forename: Naeem
authors.initials: N
authors.lastname: Tahir
authors.forename: Arshi
authors.initials: A
authors.lastname: Naz
authors.forename: Imran
authors.initials: I
authors.lastname: Naseer
authors.forename: Tasneem
authors.initials: T
authors.lastname: Farzana
authors.forename: Saqib
authors.initials: S
authors.lastname: Ansari
authors.forename: Muhammad
authors.initials: M
authors.lastname: Nadeem
authors.lastname: Zia-Ur-Rahman
authors.forename: Zainab
authors.initials: Z
authors.lastname: Sangji
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006467:Hemophilia A / Q000276:immunology / Q000382:microbiology* / Q000628:therapy*; D006509:Hepatitis B / Q000097:blood / Q000635:transmission*; D006526:Hepatitis C / Q000097:blood / Q000635:transmission*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D015995:Prevalence; D065227:Transfusion Reaction; D055815:Young Adult