title: The use of near-infrared spectrometry for the diagnosis of lower-extremity compartment syndrome.
abstract: While intracompartmental pressure monitoring is a widely used diagnostic tool to measure intracompartmental pressures in the setting of compartment syndrome, its invasive nature has prompted the development of noninvasive techniques, such as near-infrared spectrometry. We prospectively assessed the association between tissue oxygen saturation measured by near-infrared spectrometry and compartment pressure measured by intracompartmental pressure monitoring in a cohort of patients with compartment syndrome of the lower extremity. We hypothesized that tissue oxygen saturation measured by near-infrared spectrometry would negatively correlate with intracompartmental pressures. Tissue oxygen saturation was determined for all 4 compartments of the lower extremity in 7 patients using near-infrared spectrometry. All patients subsequently underwent lower-extremity fasciotomies. Mechanism of injury, compartment pressures, blood pressure, near-infrared spectrometry measurement of tissue oxygen saturation, and characteristics of the muscle at the time of fasciotomy were recorded. The strength of the correlations between tissue oxygen saturation and absolute and relative compartment pressures was estimated based on mixed linear (growth) models with repeated observations nested within patients. Our analyses demonstrated no significant relationship between tissue oxygen saturation measured by near-infrared spectrometry and the absolute or relative compartment pressures. This suggests that compartment tissue oxygen saturation measurements by near-infrared spectrometry do not correlate with the diagnosis of compartment syndrome, and that near-infrared spectrometry would not serve as a reliable diagnostic tool.
authors.affiliation: Department of Orthopedics, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. jason.bariteau@gmail.com
authors.forename: Jason T
authors.initials: JT
authors.lastname: Bariteau
authors.forename: Bryan G
authors.initials: BG
authors.lastname: Beutel
authors.forename: Robin
authors.initials: R
authors.lastname: Kamal
authors.forename: Roman
authors.initials: R
authors.lastname: Hayda
authors.forename: Christopher
authors.initials: C
authors.lastname: Born
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D003161:Compartment Syndromes / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D007259:Infrared Rays; D035002:Lower Extremity; D008297:Male; D010100:Oxygen / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010100:Oxygen