title: Genetic biomonitoring of inhabitants exposed to uranium in the north region of Brazil.
abstract: Aiming to assess the susceptibility of populations in the Brazilian Amazon region to ionizing radiation emitted from uranium, mutations frequencies in the DNA repair genes XRCC1 and XRCC3 and in the metabolic gene GSTM1 were evaluated. The XRCC1 allele frequencies for the 194Trp polymorphism in the municipalities of Monte Alegre, Prainha and Alenquer were, respectively, 0.12, 0.13 and 0.07, and for 399Gln polymorphism they were, respectively, 0.28, 0.30 and 0.32. Frequencies for GSTM1 gene deletion homozygotes were, respectively, 0.36, 0.31 and 0.40 for all municipalities. These frequencies are comparable to those described for Brazilian individuals from other regions of the country. Also, allele frequencies of XRCC3 241Met polymorphism of the Monte Alegre and Alenquer populations were 0.28 and 0.33, respectively. In conclusion, frequencies of important polymorphic features of cellular DNA repair and metabolic apparatus in the populations studied do not differ from those of populations in other regions of Brazil.
authors.affiliation: National Laboratory of Experimental Oncology, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
authors.forename: Carla Maria
authors.initials: CM
authors.lastname: Lima Sombra
authors.forename: Bruno
authors.initials: B
authors.lastname: Coêlho Cavalcanti
authors.forename: Manoel Odorico
authors.initials: MO
authors.lastname: de Moraes
authors.forename: Sidney
authors.initials: S
authors.lastname: Santos
authors.forename: Andrea
authors.initials: A
authors.lastname: Ribeiro-Dos-Santos
authors.forename: Rommel
authors.initials: R
authors.lastname: Rodríguez Burbano
authors.forename: Cláudia
authors.initials: C
authors.lastname: Pessoa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D004784:Environmental Monitoring; D005260:Female; D005787:Gene Frequency; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014501:Uranium / Q000633:toxicity*; D000076105:X-ray Repair Cross Complementing Protein 1; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D005982:Glutathione Transferase; D014501:Uranium; D000076105:X-ray Repair Cross Complementing Protein 1; C110901:X-ray repair cross complementing protein 3; C000619371:XRCC1 protein, human