title: Hepatic yersiniosis caused by Yersinia enterocolitica 4:O3 in an adult dog.
abstract: A 2-year-old Pekinese dog was diagnosed with hepatic yersiniosis. Grossly, white-to-yellow nodules consisting of degenerated inflammatory cells, cell debris, and bacterial clumps were scattered throughout the liver. Histopathologically, suppurative and necrotizing hepatitis was apparent. Yersinia enterocolitica biotype 4, serotype O3 (4:O3) was identified and confirmed in the liver immunohistochemically, using a monoclonal antibody. The virulence genes ystA and ail were detected, but the isolate was negative for autoagglutination and calcium-dependent growth. To confirm systemic yersiniosis in animals, it is imperative that the organism(s) be identified because the hepatic lesions are similar to those of Y. pseudotuberculosis and other diseases, including plague, which is also a zoonotic pathogen.
authors.affiliation: National Veterinary Research and Quarantine Service, Animal Disease Diagnostic Center, 480 Aanyang 6 dong, Anyang, Gyeonggi 430-824, Republic of Korea. jaewon8911@korea.kr
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Byun
authors.forename: Soon-Seek
authors.initials: SS
authors.lastname: Yoon
authors.forename: Suk-Kyung
authors.initials: SK
authors.lastname: Lim
authors.forename: O-Soo
authors.initials: OS
authors.lastname: Lee
authors.forename: Byeong Yeal
authors.initials: BY
authors.lastname: Jung
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000235:genetics; D001427:Bacterial Toxins / Q000737:chemistry / Q000235:genetics; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000382:microbiology* / Q000473:pathology; D004285:Dogs; D004768:Enterotoxins / Q000737:chemistry / Q000235:genetics; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D008107:Liver Diseases / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D014774:Virulence; D015009:Yersinia Infections / Q000382:microbiology / Q000662:veterinary*; D015008:Yersinia enterocolitica / Q000235:genetics / Q000302:isolation & purification*
chemical_list: C069712:Ail protein, Yersinia enterocolitica; D001425:Bacterial Outer Membrane Proteins; D001427:Bacterial Toxins; D004269:DNA, Bacterial; D004768:Enterotoxins; C048669:heat-stable enterotoxin (Yersinia)