title: Changes in cortical bone mineralization in the mouse mandible with regenerated condyle.
abstract: The objective of this study was to evaluate the effects of condylectomy and of a functional appliance on the mineral content, density, and area of the mandibular cortical bone in a growing mouse model. In the condylectomy group, a unilateral condylectomy was performed on the right side of the mouse mandible. In the condylectomy + appliance group, a functional appliance was used to reposition the mandible after the unilateral condylectomy. All mice were killed 4 wk after surgery. Each mandible was then subjected to analyses of cortical bone mineral content (CRT_CNT), cortical bone density (CRT_DEN), and cortical bone area (CRT_A) by peripheral quantitative computed tomography (pQCT). The CRT_CNT, CRT_DEN, and CRT_A values were significantly lower in the condylectomized mandible (right side) than in the non-condylectomized mandible (left side). However, in the condylectomized animals in which a functional appliance was used, the CRT_CNT, CRT_DEN, and CRT_A values became higher than those in the mice treated with condylectomy alone. No significant differences were found in the CRT_CNT, CRT_DEN, and CRT_A between non-condylectomized (left side) mandibles, mandibles treated with condylectomy + functional appliance (right side), and control mandibles. It was thus shown that a functional appliance used to reposition the condylectomized mandible forward in a symmetric position induced improvement of the cortical bone in a mouse model in terms of cortical bone mineral content, density, and area.
authors.affiliation: Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. seven@hiroshima-u.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Fujita
authors.forename: Junji
authors.initials: J
authors.lastname: Ohtani
authors.forename: Maya
authors.initials: M
authors.lastname: Shirakura
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Hayashi
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Kawata
authors.forename: Masato
authors.initials: M
authors.lastname: Kaku
authors.forename: Masahide
authors.initials: M
authors.lastname: Motokawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tanne
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D002113:Calcification, Physiologic / Q000502:physiology*; D019248:Jaw Fixation Techniques / Q000295:instrumentation*; D008334:Mandible / Q000254:growth & development* / Q000601:surgery; D019186:Mandibular Advancement / Q000295:instrumentation; D008335:Mandibular Condyle / Q000254:growth & development*; D051379:Mice; D008810:Mice, Inbred C57BL; D018709:Statistics, Nonparametric