title: Isoprenylated flavonoids and adipogenesis-promoting constituents from Morus nigra.
abstract: Ten new isoprenylated flavonoids, nigrasins A-J (1-10), and three known compounds were isolated from the twigs of Morus nigra. Compounds 8 and 9 promoted adipogenesis, characterized by increased lipid droplet and triglyceride content in 3T3L1 cells, and induced up-regulation of the expression of adipocyte-specific genes, aP2 and GLUT4.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Hu
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Wu
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhang
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Huang
authors.forename: He-Yao
authors.initials: HY
authors.lastname: Wang
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
mesh_terms: D041721:3T3-L1 Cells / Q000187:drug effects; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D001483:Base Sequence; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051275:Glucose Transporter Type 4 / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D054876:Prenylation
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D051275:Glucose Transporter Type 4