title: Serotype-specific and cross-reactive neutralizing antibody responses in cynomolgus monkeys after infection with multiple dengue virus serotypes.
abstract: Neutralizing antibody responses were examined in monkeys after dengue virus infections. In monkeys that had been infected once or twice with DENV-2, neutralizing antibody was cross-reactive with all four serotypes after secondary or tertiary infection with DENV-3. In monkeys that had been inoculated with DENV-1 and DENV-2 in the primary and secondary infections, neutralizing antibody titers did not increase after tertiary infection with DENV-3. These results indicate that antibody responses after secondary and tertiary infections with different serotypes are cross-reactive with all four serotypes, consistent with what has been observed in humans, and suggest that monkeys are useful for determining neutralizing antibody responses.
authors.affiliation: Department of Virology 1, National Institute of Infectious Disease, 1-23-1 Toyama, Shinjyuku-ku, Tokyo 162-8640, Japan. mito@nih.go.jp
authors.forename: Mikako
authors.initials: M
authors.lastname: Ito
authors.forename: Yuko
authors.initials: Y
authors.lastname: Katakai
authors.forename: Fumiko
authors.initials: F
authors.lastname: Ono
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Akari
authors.forename: Ryo-Zabro
authors.initials: RZ
authors.lastname: Mukai
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Takasaki
authors.forename: Akira
authors.initials: A
authors.lastname: Kotaki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kurane
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D003715:Dengue / Q000276:immunology* / Q000821:virology; D003716:Dengue Virus / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity; D005260:Female; D008252:Macaca fascicularis; D012703:Serotyping
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral