title: [Relationship between genetic polymorphisms of β2-adrenergic receptor gene and essential hypertension risk among the Han Chinese population: a Meta analysis].
abstract: OBJECTIVE
  To evaluate the relationship between A46G and C79G polymorphisms in the β2-adrenergic receptor (ADRB2) gene and the incidence of essential hypertension (EH) among the Han Chinese population.
  
  
  METHODS
  We conducted a computer retrieval of PUBMED, EMBASE, CNKI, Wanfang and VIP databases prior to May 2010. Articles investigating the relationship of EH and ADRB2 gene polymorphism of Han group were found through literature search, including 15 articles on A46G and 10 articles on C79G. According to the including and excluding criteria, a Meta-analysis was conducted in EH and ADRB2 gene polymorphism of A46G and C79G. The association was examined by RevMan4.2 software through quantitative analysis.
  
  
  RESULTS
  Eight articles on A46G polymorphism (including 1078 EH cases and 788 control subjects) and six articles on C79G polymorphism (including 1367 EH cases and 1006 control subjects) were included in the current study. Meta-analysis showed that there was a significant association between A46G polymorphism and EH: genotype GG/(AA + AG) (fixed-effected model, OR = 1.35, 95%CI = 1.04 - 1.74, P = 0.02), genotype GG/AA (fixed-effected model, OR = 1.41, 95%CI = 1.06 - 1.89, P = 0.02). No significant association was found between C79G polymorphism and EH of Han group in China: G/C allele comparison (random-effected model, OR = 0.88, 95%CI = 0.55 - 1.39, P = 0.57).
  
  
  CONCLUSIONS
  Significant association was found between A46G polymorphism of ADRB2 gene and EH, whereas no association could be found between C79G polymorphism and EH among Han Chinese population.
authors.affiliation: Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
authors.forename: Yu-qing
authors.initials: YQ
authors.lastname: Lou
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.forename: Hai
authors.initials: H
authors.lastname: Wu
authors.forename: Zuo-guang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Kuo
authors.initials: K
authors.lastname: Liu
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.forename: Zhi-zhong
authors.initials: ZZ
authors.lastname: Li
authors.forename: Shao-jun
authors.initials: SJ
authors.lastname: Wen
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C553443:ADRB2 protein, human; D018343:Receptors, Adrenergic, beta-2