title: [Application of serum proteomic patterns for the detection of esophageal carcinoma in Kazakh in Xinjiang].
abstract: OBJECTIVE
  To detect the serum protein profiles of Kazakh's esophageal carcinoma (EC) patients in Xinjiang by SELDI-TOF-MS (surface enhanced laser desorption & ionization time-of-flight mass spectrometry) and build up a diagnostic model of Kazakh's EC in Xinjiang.
  
  
  METHODS
  The serum samples from 41 Kazakh's EC patients and 20 Kazakh's healthy controls were collected and analyzed on weak cation exchange and hydrophobic surface protein chip by SELDI-TOF-MS technology. The differentially expressed markers of esophageal carcinoma were detected.
  
  
  RESULTS
  The values of M/Zs were significantly different between Kazakh's EC patients and controls (P < 0.05). Among these, 6 proteins peaks were up-regulated (5495.2265, 15 964.6951, 16 152.0872, 4488.4818, 8164.7652, 4979.4223) and 4 down-regulated (6900.3285, 13 790.9241, 8790.8130, 8714.7915) in the Kazakh's EC group. According to cross validation, the model of Kazakh's EC made up of 7 proteins (M/Z 6900.3285, 13 790.9241, 8790.8130, 15 964.6951, 16 152.0872, 4488.4818, 4979.4223) was established. The sensitivity and specificity of this model were 100% (41/41) and 100% (20/20) respectively.
  
  
  CONCLUSIONS
  The model with 7 proteins markers has a higher sensitivity and specificity for Kazakh's EC patients in Xinjiang. It may provide a new serum diagnostic tool for Kazakh's EC patients in Xinjiang.
authors.affiliation: Department of Thoracic Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumuqi 830000, China.
authors.forename: Chang-ming
authors.initials: CM
authors.lastname: Zhang
authors.forename: Hai-ping
authors.initials: HP
authors.lastname: Zhang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yu-qing
authors.initials: YQ
authors.lastname: Ma
authors.forename: Qing-chao
authors.initials: QC
authors.lastname: Sun
authors.forename: Julaiti
authors.initials: J
authors.lastname: Ainiwaer
authors.forename: Ilyar
authors.initials: I
authors.lastname: Sheyhidin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001798:Blood Proteins / Q000032:analysis*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D040081:Protein Array Analysis; D020543:Proteome / Q000032:analysis*; D040901:Proteomics; D012680:Sensitivity and Specificity; D044967:Serum / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D001798:Blood Proteins; D020543:Proteome