title: Revealing the nature of thio-click reactions on the solid phase.
abstract: Thiol- and yne-functionalized beads were manufactured in a simple microfluidic setup. While CuAAC and thiol-yne reactions were performed on yne-functionalized beads, 9 different thiol-X reactions were compared, in terms of kinetics and conversion, on thiol-functionalized beads.
authors.affiliation: Department of Organic Chemistry, Polymer Chemistry Research Group, Ghent University, Krijgslaan 281 S4-bis, B-9000 Ghent, Belgium.
authors.forename: M Talha
authors.initials: MT
authors.lastname: Gokmen
authors.forename: Jérémy
authors.initials: J
authors.lastname: Brassinne
authors.forename: R Arun
authors.initials: RA
authors.lastname: Prasath
authors.forename: Filip E
authors.initials: FE
authors.lastname: Du Prez
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D007700:Kinetics; D046210:Microfluidic Analytical Techniques; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010316:Particle Size; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000480:Alkynes; D001386:Azides; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D003300:Copper