title: Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine.
abstract: Addiction is a brain chronic relapsing disorder associated with emotional distress. The serotonergic system and especially the 5-HT(1A) receptor crucially regulate emotional behaviors both in humans and rodents. Using [(35)S]GTPγS autoradiography in mice, we show that 5-HT(1A) receptor function is enhanced by chronic morphine treatment in the medial prefrontal cortex, and decreased in dorsal raphe nucleus one week later, two regions involved in emotional processing. These molecular adaptations could contribute to the development of emotional disorders experienced by former opiate addicts.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de Strasbourg, 1 Rue Laurent Fries, 67404 Illkirch, France.
authors.forename: Pierre-Eric
authors.initials: PE
authors.lastname: Lutz
authors.forename: Amynah A
authors.initials: AA
authors.lastname: Pradhan
authors.forename: Celia
authors.initials: C
authors.lastname: Goeldner
authors.forename: Brigitte L
authors.initials: BL
authors.lastname: Kieffer
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D001345:Autoradiography; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000008:administration & dosage*; D009294:Narcotics / Q000008:administration & dosage*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D011903:Raphe Nuclei / Q000187:drug effects / Q000378:metabolism*; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013462:Sulfur Radioisotopes / Q000493:pharmacokinetics; D013997:Time Factors
chemical_list: D009294:Narcotics; D017366:Serotonin Receptor Agonists; D013462:Sulfur Radioisotopes; D044282:Receptor, Serotonin, 5-HT1A; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D009020:Morphine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin