title: In vivo anomalous diffusion and weak ergodicity breaking of lipid granules.
abstract: Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.
authors.affiliation: Physics Department T30g, Technical University of Munich, Garching, Germany.
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Jeon
authors.forename: Vincent
authors.initials: V
authors.lastname: Tejedor
authors.forename: Stas
authors.initials: S
authors.lastname: Burov
authors.forename: Eli
authors.initials: E
authors.lastname: Barkai
authors.forename: Christine
authors.initials: C
authors.lastname: Selhuber-Unkel
authors.forename: Kirstine
authors.initials: K
authors.lastname: Berg-Sørensen
authors.forename: Lene
authors.initials: L
authors.lastname: Oddershede
authors.forename: Ralf
authors.initials: R
authors.lastname: Metzler
mesh_terms: D004058:Diffusion; D050356:Lipid Metabolism; D009068:Movement; D052898:Optical Tweezers; D012568:Schizosaccharomyces / Q000166:cytology / Q000378:metabolism; D013997:Time Factors