title: A novel pneumococcus with a new association.
abstract: A case of severe invasive pneumococcal disease in a 68 year old female is described. She presented following a holiday in Turkey with an uncommon but well documented complication of Streptococcus pneumoniae bacteraemia; Austrian's triad of meningitis, pneumonia and endocarditis. She then progressed to develop an atypical variant of Guillain Barre syndrome, never previously documented in association with pneumococcal disease. The pneumococcus was identified as serotype 6A and genetic typing by multi-locus sequence typing showed it to be a unique genetic profile (ST4533). We hypothesise that ST4533 may have resulted from genetic re-assortment from streptococci which had colonised the patient in the United Kingdom and bacteria encountered in Turkey. The ability to associate uncommon genotypes with uncommon clinical presentations may improve understanding of the pathogenesis of this organism, and this highlights the need for international invasive pneumococcal disease surveillance.
authors.affiliation: Infectious Diseases Unit, Monklands Hospital, Monkscourt Avenue, Airdrie ML6 OJS, UK. bwhite@nhs.net
authors.forename: B
authors.initials: B
authors.lastname: White
authors.forename: M
authors.initials: M
authors.lastname: Diggle
authors.forename: A
authors.initials: A
authors.lastname: Todd
authors.forename: S
authors.initials: S
authors.lastname: Dundas
authors.forename: D
authors.initials: D
authors.lastname: Inverarity
mesh_terms: D000368:Aged; D016470:Bacteremia / Q000175:diagnosis / Q000382:microbiology; D017548:Echocardiography, Transesophageal; D004697:Endocarditis, Bacterial / Q000382:microbiology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000175:diagnosis / Q000382:microbiology*; D006801:Humans; D008586:Meningitis, Pneumococcal / Q000382:microbiology; D058885:Multilocus Sequence Typing; D011008:Pneumococcal Infections / Q000150:complications / Q000175:diagnosis / Q000382:microbiology*; D011018:Pneumonia, Pneumococcal / Q000382:microbiology; D012606:Scotland; D013296:Streptococcus pneumoniae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D014421:Turkey