title: [Association of elevated uric acid with metabolic disorders and analysis of the risk factors of hyperuricemia in type 2 diabetes mellitus].
abstract: OBJECTIVE
  To explore the association of elevated serum uric acid with metabolic disorders and the risk factors of hyperuricemia in type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  The clinical and laboratory data of 159 T2DM patients aged 40-80 years with a Scr level of 51-159 µmol/L (0.6-1.8 mg/dl) were analyzed to explore the association of hyperuricemia (HUA) with metabolic disorders and identify the risk factors of HUA.
  
  
  RESULTS
  Forty out of 159 T2DM patients (25.2%) were found to have HUA. Univariate analysis showed that male gender, a body mass index ≤25 kg/m(2), hypertension, serum creatinine ≤110 µmol/L, blood urea nitrogen ≤7.0 mmol/L, microalbuminuria :11.2 mg/L, triglyceride :1.70 mmol/L, high-density lipoprotein <1.04 mmol/L, low density lipoprotein ≤3.37 mmol/L were all risk factors of HUA (P<0.05) in T2DM. Binary logistic regression analysis identified serum creatinine, body mass index and triglyceride as independent risk factors of HUA in T2DM. The main risk factors related to HUA had high incidences in T2DM. Patients with HUA had a significantly higher incidences of coronary artery disease, carotid atherosclerosis, cerebral infarction, diabetic nephropathy and diabetic retinopathy than those with normal uric acid level (P<0.05).
  
  
  CONCLUSIONS
  Several risk factors contribute to the occurrence of elevated serum uric acid in T2DM, and metabolic disorders and complications are also closely associated with HUA.
authors.affiliation: Department of Nephropathy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. wudanjw@21cn.com
authors.forename: Dan
authors.initials: D
authors.lastname: WU
authors.forename: Hong
authors.initials: H
authors.lastname: LIU
authors.forename: Shen-heng
authors.initials: SH
authors.lastname: LI
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid