title: Gene discovery in Triatoma infestans.
abstract: BACKGROUND
  Triatoma infestans is the most relevant vector of Chagas disease in the southern cone of South America. Since its genome has not yet been studied, sequencing of Expressed Sequence Tags (ESTs) is one of the most powerful tools for efficiently identifying large numbers of expressed genes in this insect vector.
  
  
  RESULTS
  In this work, we generated 826 ESTs, resulting in an increase of 47% in the number of ESTs available for T. infestans. These ESTs were assembled in 471 unique sequences, 151 of which represent 136 new genes for the Reduviidae family.
  
  
  CONCLUSIONS
  Among the putative new genes for the Reduviidae family, we identified and described an interesting subset of genes involved in development and reproduction, which constitute potential targets for insecticide development.
authors.affiliation: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín-CONICET, Av, Gral Paz 5445, Edificio 24, B1650KNA, San Martín, Provincia de Buenos Aires, Argentina.
authors.forename: María L
authors.initials: ML
authors.lastname: Avila
authors.forename: Valeria
authors.initials: V
authors.lastname: Tekiel
authors.forename: Georgina
authors.initials: G
authors.lastname: Moretti
authors.forename: Soledad
authors.initials: S
authors.lastname: Nicosia
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Bua
authors.forename: Estela M
authors.initials: EM
authors.lastname: Lammel
authors.forename: María M
authors.initials: MM
authors.lastname: Stroppa
authors.forename: Nelia M
authors.initials: NM
authors.lastname: Gerez de Burgos
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Sánchez
mesh_terms: D000818:Animals; D001118:Argentina; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D004199:Disease Vectors; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling / Q000379:methods; D056726:Genetic Association Studies / Q000379:methods*; D017422:Sequence Analysis, DNA; D014224:Triatoma / Q000235:genetics*
chemical_list: D018076:DNA, Complementary