title: Interactome networks and human disease.
abstract: Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
authors.affiliation: Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. marc_vidal@dfci.harvard.edu
authors.forename: Marc
authors.initials: M
authors.lastname: Vidal
authors.forename: Michael E
authors.initials: ME
authors.lastname: Cusick
authors.forename: Albert-László
authors.initials: AL
authors.lastname: Barabási
mesh_terms: D004194:Disease / Q000235:genetics*; D053263:Gene Regulatory Networks; D006801:Humans; D053858:Metabolic Networks and Pathways; D025941:Protein Interaction Mapping; D011506:Proteins / Q000378:metabolism*; D049490:Systems Biology
chemical_list: D011506:Proteins