title: A new rearranged abietane diterpenoid from Clerodendrum kaichianum Hsu.
abstract: A new abietane diterpenoid, (3S,16R)-12,16-epoxy-3,6,11,14,17-pentahydroxy-17(15 → 16)-abeo-5,8,11,13-abietatetraen-7-one (1), was isolated from the stems of Clerodendrum kaichianum Hsu, together with four known diterpenoids. The structures of the isolated compounds were assigned on the basis of their NMR spectra including 2D NMR techniques such as COSY, HMQC, and HMBC experiments, and were compared with those of the literature data. This new compound showed significant cytotoxicity against the HL-60 and A-549 tumor cell lines.
authors.affiliation: College of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou, China.
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Xu
authors.forename: Lian-Qing
authors.initials: LQ
authors.lastname: Shen
authors.forename: Kui-Wu
authors.initials: KW
authors.lastname: Wang
authors.forename: Qi-Zhen
authors.initials: QZ
authors.lastname: Du
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D032409:Clerodendrum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: C558052:(3S,16R)-12,16-epoxy-3,6,11,14,17-pentahydroxy-17(15-16)-abeo-5,8,11,13-abietatetraen-7-one; D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal