title: Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii.
abstract: Infections caused by Acinetobacter baumannii are of increasing concern, largely due to the multidrug resistance of many strains. Here we show that insertion sequence ISAba11 movement can result in inactivation of the A. baumannii lipid A biosynthesis genes lpxA and lpxC, resulting in the complete loss of lipopolysaccharide production and high-level colistin resistance.
authors.affiliation: Department of Microbiology, Monash University, Victoria, Australia.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Moffatt
authors.forename: Marina
authors.initials: M
authors.lastname: Harper
authors.forename: Ben
authors.initials: B
authors.lastname: Adler
authors.forename: Roger L
authors.initials: RL
authors.lastname: Nation
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: John D
authors.initials: JD
authors.lastname: Boyce
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D004251:DNA Transposable Elements; D008050:Lipid A / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements; D008050:Lipid A; D008070:Lipopolysaccharides; D003091:Colistin