title: c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators.
abstract: The ubiquitous bacterial biofilm regulator, c-di-GMP can form G-quadruplexes at physiological conditions in the presence of some aromatic compounds, such as acriflavine and proflavine. The fluorescence of these compounds is quenched upon c-di-GMP binding and some of the formed c-di-GMP G-quadruplexes are stable even at 75 °C.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
authors.forename: Shizuka
authors.initials: S
authors.lastname: Nakayama
authors.forename: Ilana
authors.initials: I
authors.lastname: Kelsey
authors.forename: Jingxin
authors.initials: J
authors.lastname: Wang
authors.forename: Herman O
authors.initials: HO
authors.lastname: Sintim
mesh_terms: D000167:Acriflavine / Q000737:chemistry*; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000737:chemistry; D005453:Fluorescence; D054856:G-Quadruplexes; D011370:Proflavine / Q000737:chemistry*; D013696:Temperature
chemical_list: D000167:Acriflavine; C062025:bis(3',5')-cyclic diguanylic acid; D011370:Proflavine; D006152:Cyclic GMP