title: Diagnosis-to-treatment interval and control of locoregionally advanced head and neck cancer.
abstract: OBJECTIVE
  To assess the impact of prolonged diagnosis-to-treatment interval (DTI) that falls in the time frame associated with the increasing complexity of planning treatment for patients with locoregionally advanced head and neck cancer (LAHNC).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  The University of Alabama at Birmingham.
  
  
  METHODS
  An institutional database was searched for all patients with LAHNC who were treated with radiotherapy between 1995 and 2007 at the University of Alabama at Birmingham. After patients with prior treatment for head and neck cancer (including surgery or neoadjuvant chemotherapy), patients younger than 18 years, and patients with stage I or II tumors were excluded, 427 patients remained for analysis.
  
  
  METHODS
  The DTI was defined as the time in days between the date that a biopsy specimen showing malignancy was obtained and the first day of radiotherapy.
  
  
  RESULTS
  The median DTI was 34 days (range, 7-441 days). A longer DTI was not significantly associated with locoregional control (P = .11), distant metastases-free survival (P = .32), or overall survival (P = .07).
  
  
  CONCLUSIONS
  A prolonged DTI did not appear to adversely affect outcomes in this cohort of patients with LAHNC.
authors.affiliation: Department of Radiation Oncology, University of Mississippi Medical Center, 350 Woodrow Wilson Dr, Ste 1600, Jackson, MS 39213, USA. jjcaudell@gmail.com
authors.forename: Jimmy J
authors.initials: JJ
authors.lastname: Caudell
authors.forename: Julie L
authors.initials: JL
authors.lastname: Locher
authors.forename: James A
authors.initials: JA
authors.lastname: Bonner
mesh_terms: D000328:Adult; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D057210:Delayed Diagnosis; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D019458:Insurance Coverage / Q000706:statistics & numerical data; D008297:Male; D009367:Neoplasm Staging; D010039:Otorhinolaryngologic Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D016896:Treatment Outcome; D014481:United States