title: Catalysis by the nucleolytic ribozymes.
abstract: The nucleolytic ribozymes use general acid-base catalysis to contribute significantly to their rate enhancement. The VS (Varkud satellite) ribozyme uses a guanine and an adenine nucleobase as general base and acid respectively in the cleavage reaction. The hairpin ribozyme is probably closely similar, while the remaining nucleolytic ribozymes provide some interesting contrasts.
authors.affiliation: Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK. d.m.j.lilley@dundee.ac.uk
authors.forename: David M J
authors.initials: DM
authors.lastname: Lilley
mesh_terms: D000818:Animals; D002384:Catalysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008954:Models, Biological; D008958:Models, Molecular; D009711:Nucleotides / Q000378:metabolism*; D016337:RNA, Catalytic / Q000378:metabolism*
chemical_list: D009711:Nucleotides; D016337:RNA, Catalytic