title: [Circadian blood pressure variability and plasma neopterin level before and after surgery for obstructive sleep apnea syndrome].
abstract: OBJECTIVE
  To investigate the change of circadian blood pressure variability (BPV) and plasma neopterin before and after surgery (uvulopalatopharyngoplasty) for patients with obstructive sleep apnea syndrome (OSAS).
  
  
  METHODS
  A total of 382 OSAS patients underwent uvulopalatopharyngoplasty were divided into three groups based on polysomnography (PSG) results: mild OSAS (n = 206), moderate OSAS (n = 108) and severe OSAS (n = 68). Plasma neopterin, 24-hour ambulatory blood pressure monitoring (ABPM), PSG were measured before and 3 months after surgery.
  
  
  RESULTS
  Plasma neopterin increased in proportion to severity of OSAS before surgery (15.08 nmol/L, 27.68 nmol/L and 37.32 nmol/L in patients with mild to severe OSAS) which were significantly reduced post surgery (9.92 ng/ml, 15.07 ng/ml and 18.54 ng/ml, all P < 0.05 vs. pre-surgery). The incidence of non-dipper curve in three OSAS groups were 50.2%, 72.7% and 86.5%, respectively before surgery and the values decreased to 34.8%, 48.2% and 49.2% after surgery (all P < 0.05 vs. pre-surgery). Relevance analysis indicates that D-value of nocturnal and diurnal blood pressure was negatively correlated with plasma neopterin.
  
  
  CONCLUSIONS
  Our findings indicated that plasma neopterin and the incidence of non-dipper could reliably reflect OSAS severity and could thus be used to evaluate the surgery efficacy. Plasma neopterin might be an important player in the pathophysiology of OSAS via modulating blood pressure variability.
authors.affiliation: Department of Heart and Circulation, People's Liberation Army General Hospital, Beijing 101149, China. hailing0410@sina.com
authors.forename: Hai-ling
authors.initials: HL
authors.lastname: Wang
authors.forename: Yun-dai
authors.initials: YD
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xin-chun
authors.initials: XC
authors.lastname: Wang
authors.forename: Zhi-xuan
authors.initials: ZX
authors.lastname: Liu
authors.forename: Guo-li
authors.initials: GL
authors.lastname: Jing
authors.forename: Hai-feng
authors.initials: HF
authors.lastname: Tong
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.forename: Ke
authors.initials: K
authors.lastname: Shi
authors.forename: Qing-zeng
authors.initials: QZ
authors.lastname: Liu
mesh_terms: D000328:Adult; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood*; D013517:Otorhinolaryngologic Surgical Procedures; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000503:physiopathology* / Q000601:surgery*
chemical_list: D019798:Neopterin