title: Is there any relationship between coronary artery disease and postprandial triglyceride levels?
abstract: OBJECTIVE
  We aimed to evaluate the relationship between postprandial triglyceride (PPTG) levels and coronary artery disease (CAD).
  
  
  METHODS
  A total of 80 patients were included in this prospective cohort study. Oral lipid loading was used in order to measure PPTG levels. In the fasting state and after the high fat breakfast, triglyceride levels were measured by enzymatic methods at 2nd, 4th, 6th and 8th hours. We made subgroup analysis to show the effects of lipid loading on triglyceride levels in patients with and without fasting hypertriglyceridemia. We evaluated triglyceride levels and changes of triglyceride levels in percentages after lipid loading using a general linear model for repeated measures. Sample size analysis was performed.
  
  
  RESULTS
  Baseline clinical, demographic and laboratory characteristics of both groups were similar. The peak triglyceride levels were seen at the 4th hour in both groups. Triglyceride levels were significantly increased after lipid-rich-breakfast loading compared to baseline levels in both groups (p<0.001) but these changes were not significant (p=0.279). In patients with elevated fasting triglyceride levels, the area under the plasma triglyceride concentration curve was significantly larger in CAD group than control group (334±103 vs. 233±58 mg/dl, p=0.02).
  
  
  CONCLUSIONS
  Our data show that in patients who have a high fasting triglyceride level, high levels of PPTG may be related to CAD, however high PPTG levels are not related to CAD in patients with normal fasting levels of triglyceride.
authors.affiliation: Cardiology Clinic, Güven Hospital, Ankara, Turkey.
authors.forename: Inci Aslı
authors.initials: IA
authors.lastname: Atar
authors.forename: Ilyas
authors.initials: I
authors.lastname: Atar
authors.forename: Alp
authors.initials: A
authors.lastname: Aydınalp
authors.forename: Cağatay
authors.initials: C
authors.lastname: Ertan
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Bozbaş
authors.forename: Bülent
authors.initials: B
authors.lastname: Ozin
authors.forename: Aylin
authors.initials: A
authors.lastname: Yıldırır
authors.forename: Haldun
authors.initials: H
authors.lastname: Müderrisoğlu
mesh_terms: D000368:Aged; D015331:Cohort Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications* / Q000453:epidemiology; D008055:Lipids / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011446:Prospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D008055:Lipids; D014280:Triglycerides