title: Antioxidant and antibacterial activities of bark extracts from Commiphora berryi and Commiphora caudata.
abstract: This study investigates the in vitro antioxidant and antimicrobial activities of eight extracts obtained from the dried barks of Commiphora berryi and Commiphora caudata (Burseraceae). The radical scavenging activity was assessed by 1,1-diphenyl-2-picryl hydrazyl (DPPH) and nitric oxide assays. The methanolic extracts of C. berryi and C. caudata showed significant DPPH radical scavenging activity, with IC₅₀ values of 26.92 and 21.16 µg mL⁻¹, respectively, and low radical scavenging activity against the nitric oxide assay. The antimicrobial activity of the plants was tested against the Gram-positive and Gram-negative bacteria. The ethyl acetate, chloroform and petroleum ether extracts of C. berryi showed good antibacterial activity against Pseudomonas aeruginosa, with a minimum inhibitory concentration (MIC) of 0.26 mg mL⁻¹, whereas the ethyl acetate and methanol extracts of C. caudata showed moderate antimicrobial activity with an MIC of more than 2.0 mg mL⁻¹ against P. aeruginosa compared to the petroleum ether and chloroform extracts, which showed an MIC of 1.1 mg mL⁻¹. The methanolic extracts of C. berryi and C. caudata also showed moderate cytotoxic activity against a human mammary carcinoma cell line (MCF-7), with values IC₅₀ of 82.6 and 88.4 µg mL⁻¹, respectively.
authors.affiliation: Department of Medicinal Chemistry, Indian Institute of Chemical Biology, Unit of CSIR, Government of India, 4 Raja S.C. Mullick Road, Jadavpur, Calcutta 700032, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Kumari
authors.forename: Arumugam
authors.initials: A
authors.lastname: Meyyappan
authors.forename: Debkumar
authors.initials: D
authors.lastname: Nandi
authors.forename: Bikram Keshari
authors.initials: BK
authors.lastname: Agrawalla
authors.forename: Avik Acharya
authors.initials: AA
authors.lastname: Chowdhury
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Selvamani
authors.forename: Subbaiah
authors.initials: S
authors.lastname: Latha
authors.forename: Venkatachalam Sesha
authors.initials: VS
authors.lastname: Giri
authors.forename: Joydeep
authors.initials: J
authors.lastname: Mukherjee
authors.forename: Santu
authors.initials: S
authors.lastname: Bandyopadhyay
authors.forename: Parasuraman
authors.initials: P
authors.lastname: Jaisankar
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D045744:Cell Line, Tumor; D029744:Commiphora / Q000737:chemistry* / Q000145:classification; D004354:Drug Screening Assays, Antitumor; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D010936:Plant Extracts