title: UPF1 learns to relax and unwind.
abstract: In this issue of Molecular Cell, Chakrabarti et al. (2011) structurally reveal how UPF1, an RNA helicase that plays a central role in nonsense-mediated mRNA decay, is conformationally converted from a largely inactive state to an active state upon UPF2 binding.
authors.affiliation: Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. michael_gleghorn@urmc.rochester.edu
authors.forename: Michael L
authors.initials: ML
authors.lastname: Gleghorn
authors.forename: Lynne E
authors.initials: LE
authors.lastname: Maquat