title: [The expression and clinical significance of HIF-1α, COX-2 and E-cadherin in patients with lung adenocarcinoma].
abstract: OBJECTIVE
  The incidence of lung adenocarcinoma increases rapidly, and hypoxia-inducible factor-1α (HIF-1α), cyclooxygenase-2 (COX-2), E-cadherin play an important role in the proliferation and differentiation of cancer cell. The aim of this study is to investigate the clinical significance of the expression of HIF-1α, COX-2, E-cadherin in patients with lung adenocarcinoma and the internal relationship among them.
  
  
  METHODS
  The expression levels of HIF-1α, COX-2 and E-cadherin were determined in 10 cases of normal lung issue and in 45 cases of issue of lung adenocarcinoma by immunohistochemical method.
  
  
  RESULTS
  The positive expression rate of HIF-1α and COX-2 was 60% (27/45) and 40% (18/45) respectively in 45 cases of lung adenocarcinoma, was null in 10 cases of normal lung issue. The positive expression rate of E-cadherin was 48.9% (22/45) in 45 cases of lung adenocarcinoma, was 100% in 10 cases of normal lung issue. The expression of HIF-1α was positively correlated with the size of the cancer (P < 0.05), but not with age, smoking, lymphatic metastasis, differentiated degree and surgical-pathologic staging (P > 0.05). The expression of COX-2 was positively correlated with the size of the cancer, lymphatic metastasis, surgical-pathologic and expression of HIF-1α (P < 0.05), but not with age, smoking and differentiated degree (P > 0.05). The expression of E-cadherin was positively correlated with differentiated degree and lymphatic metastasis (P < 0.05), but not with age, smoking, the size of the cancer, surgical-pathologic and expression of HIF-1α (P > 0.05).
  
  
  CONCLUSIONS
  The overexpression of HIF-1α and COX-2 and the downregulation of E-cadherin is found in lung adenocarcinoma. The overexpression of HIF-1α may induce the overexpression of COX-2, and is non-correlated with expression of E-cadherin.
authors.affiliation: Graduate School, Tianjin Medical University, Department of Thoracic Medicine, Tianjin Chest Hospital, Tianjin, China. kacano@hotmail.com
authors.forename: Songtao
authors.initials: S
authors.lastname: Gu
authors.forename: Jianwen
authors.initials: J
authors.lastname: Qin
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism; D000077192:Adenocarcinoma of Lung; D000368:Aged; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics* / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D015820:Cadherins; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human