title: A case of drowning whilst under the influence of brotizolam, flunitrazepam and ethanol.
abstract: A case of drowning involving brotizolam, flunitrazepam and ethanol ingestion was presented. Quantitative toxicological analysis showed that the concentrations of brotizolam, 7-aminoflunitrazepam (a metabolite of flunitrazepam) and ethanol in the femoral blood were 0.025 microg/ml, 0.094 microg/ml and 0.29 mg/ml, respectively, and these drugs were also detected in the stomach contents. We concluded that the cause of death was drowning whilst under the influence of combined use of brotizolam, flunitrazepam and ethanol.
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1 Miki, Kagawa, 761-0793, Japan. ntanaka@med.kagowa-u.ac.jp
authors.forename: Naoko
authors.initials: N
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Mostofa
authors.initials: M
authors.lastname: Jamal
authors.forename: Eriko
authors.initials: E
authors.lastname: Ohkubo
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kumihashi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ameno
mesh_terms: D000368:Aged; D000435:Alcoholic Intoxication / Q000175:diagnosis; D014151:Anti-Anxiety Agents / Q000032:analysis*; D001381:Azepines / Q000032:analysis*; D002492:Central Nervous System Depressants / Q000032:analysis*; D004332:Drowning / Q000209:etiology; D062787:Drug Overdose; D000431:Ethanol / Q000032:analysis*; D005260:Female; D005445:Flunitrazepam / Q000032:analysis*; D005554:Forensic Medicine; D006801:Humans; D006993:Hypnotics and Sedatives / Q000032:analysis*
chemical_list: D014151:Anti-Anxiety Agents; D001381:Azepines; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D000431:Ethanol; C020960:brotizolam; D005445:Flunitrazepam