title: [Antimicrobial susceptibility of clinical isolates of aerobic Gram-negative bacteria in 2006].
abstract: We determined MICs of antibacterial agents against 1280 clinical strains of aerobic Gram-negative bacteria (19 genus or species) isolated at 16 Japanese facilities in 2006. MICs were determined using mostly broth microdilution method and antibacterial activity was assessed. Strains producing extended-spectrum beta-lactamases (ESBL) accounted for 3.7% of Escherichia coli, 2.7% of Klebsiella spp., and 11.4% of Proteus spp. Notably, 18.8% of Proteus mirabilis was found to produce ESBL higher than 16.7% in 2004. This result was higher extremely than other species. Among Haemophilus influenzae, only 1.2% produced beta-lactamase and 62.8% that increased compared with 57.7% in 2004, were beta-lactamase-negative ampicillin-resistant strains when classified by penicillin-binding protein 3 mutation. Although few antibacterial agents against Pseudomonas aeruginosa have potent activity, only three agents--doripenem, ciprofloxacin, and tobramycin-showed an MIC90 of 4 microg/mL. Of all P aeruginosa strains, 5.7% were resistant to six or more agents of nine antipseudomonal agents, a decrease compared to 8.7% in 2004. Against other glucose-non-fermentative Gram-negative bacteria, the activity of most antibacterial agents was similar to that in 2004.
authors.affiliation: Developmental Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
authors.forename: Isamu
authors.initials: I
authors.lastname: Yoshida
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Itoh
authors.forename: Mineji
authors.initials: M
authors.lastname: Tachibana
authors.forename: Choichiro
authors.initials: C
authors.lastname: Takahashi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kaku
authors.forename: Keiji
authors.initials: K
authors.lastname: Kanemitsu
authors.forename: Masahiko
authors.initials: M
authors.lastname: Okada
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Horikawa
authors.forename: Joji
authors.initials: J
authors.lastname: Shiotani
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kino
authors.forename: Yuka
authors.initials: Y
authors.lastname: Ono
authors.forename: Hisashi
authors.initials: H
authors.lastname: Baba
authors.forename: Shuji
authors.initials: S
authors.lastname: Matsuo
authors.forename: Seishi
authors.initials: S
authors.lastname: Asari
authors.forename: Masahiro
authors.initials: M
authors.lastname: Toyokawa
authors.forename: Kimiko
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Nobuchika
authors.initials: N
authors.lastname: Kusano
authors.forename: Motoko
authors.initials: M
authors.lastname: Nose
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Murase
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Miyamoto
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Saikawa
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Yamane
authors.forename: Isamu
authors.initials: I
authors.lastname: Nakasone
authors.forename: Hideki
authors.initials: H
authors.lastname: Maki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Yamano
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents