title: [Effect of short-term intensive therapy with glimepiride and metformin in newly diagnosed type 2 diabetic patients].
abstract: OBJECTIVE
  To evaluate the effect of short-term intensive therapy on blood glucose control, BETA-cell function, and blood lipid levels in newly diagnosed type 2 diabetic patients.
  
  
  METHODS
  Out-patients with newly diagnosed type 2 diabetic patients were enrolled for intensive treatment with sulfonylureas and metformin for 12 weeks, and the therapeutic effect was evaluated.
  
  
  RESULTS
  After the intensive treatment, FPG, 2 hPG, and HbA1c decreased significantly (P<0.01); HOMA-IR decreased and HOMA-B increased significantly (P<0.01), and TG, CHOL, LDL decreased significantly (P<0.01) after the treatment.
  
  
  CONCLUSIONS
  Short-term intensive treatment with glimepiride combined with metformin is safe and effective in newly diagnosed type 2 diabetic patients with HbA1c>9%.
authors.affiliation: Department of Endocrinology and Tuberculosis, Guangzhou Chest Hospital, Guangzhou 510095, China. gfmhx96@fimmu.com
authors.forename: Min
authors.initials: M
authors.lastname: WANG
authors.forename: Fang
authors.initials: F
authors.lastname: GAO
authors.forename: Yao-ming
authors.initials: YM
authors.lastname: XUE
authors.forename: Ya-juan
authors.initials: YJ
authors.lastname: HAN
authors.forename: Xia-jun
authors.initials: XJ
authors.lastname: FU
authors.forename: Fei-ying
authors.initials: FY
authors.lastname: HE
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013453:Sulfonylurea Compounds; C057619:glimepiride; D008687:Metformin