title: [A survey of nonsteroidal anti-inflammatory drugs and aspirin associated peptic ulcer bleeding in hospitals].
abstract: OBJECTIVE
  To investigate the clinical characteristic and prognosis of nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin associated peptic ulcer bleeding.
  
  
  METHODS
  All patients with peptic ulcer bleeding were studied by the same researcher after admission and discharge.
  
  
  RESULTS
  Fifty-one cases with NSAIDs and aspirin medication of the total peptic ulcer bleeding patients (147 cases) were included (34.7%). Compared with patients not associated with NSAIDs and aspirin medication, they are older [(41.2 ± 1.9) years vs (59.4 ± 2.2) years, P < 0.001], more commonly associated with hypertension (10.4% vs 39.2%, P < 0.001), coronary heart disease (10.4% vs 17.6%, P < 0.001), diabetes (4.2% vs 19.6%, P = 0.005); and had more severe anemia (7.3% vs 23.5%, P = 0.008). Fewer patients in NSAIDs group had epigastric pain (61.5% vs 27.5%, P < 0.001), while there was more re-bleeding (9.4% vs 15.7%, P = 0.034). In all bleeding patients, factors associated with re-bleeding, surgical intervention and death included NSAIDs and aspirin medication, and low platelet count. In patients with NSAIDs and aspirin medication, re-bleeding was associated with previous ulcer history (P < 0.05).
  
  
  CONCLUSIONS
  Peptic ulcer bleeding patients with NSAIDs and aspirin medication were more severe ill, and less likely to present with epigastric pain.
authors.affiliation: Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China. xiazhiwei@medmail.com.cn
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Xia
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Yao
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology*; D017678:Sex Distribution; D011795:Surveys and Questionnaires
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin