title: Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil.
abstract: In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.
authors.affiliation: Departamento de Infectologia, Hospital Heliópolis, Rua Conego Xavier 276, Sao Paulo, SP, Brazil. elisa.m.beirao@gmail.com
authors.forename: Elisa Maria
authors.initials: EM
authors.lastname: Beirão
authors.forename: Juvencio Jose Duailibe
authors.initials: JJ
authors.lastname: Furtado
authors.forename: Raquel
authors.initials: R
authors.lastname: Girardello
authors.forename: Heli
authors.initials: H
authors.lastname: Ferreira Filho
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Gales
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D001938:Brazil; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase