title: [Experimental study of Ingavirin antiviral activity against human adenovirus].
abstract: Antiviral properties of Ingavirin were investigated in the Hep-2 cell culture with respect to the human respiratory tract virus (type 5 adenovirus). In concentrations of Ingavirin of 1000, 100 and 10 mcg/ml the generated posterity showed lower infective capacity (by 250, 100 and 10 times respectively). The electron microscopy of the infected cells confirmed the Ingavirin ability to disturb the adenovirus normal morphogenesis.
authors.forename: V V
authors.initials: VV
authors.lastname: Zarubaev
authors.forename: A V
authors.initials: AV
authors.lastname: Slita
authors.forename: A K
authors.initials: AK
authors.lastname: Sirotkin
authors.forename: V E
authors.initials: VE
authors.lastname: Nebol'sin
authors.forename: O I
authors.initials: OI
authors.lastname: Kiselev
mesh_terms: D000260:Adenoviruses, Human / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D000577:Amides / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002208:Caproates; D002467:Cell Nucleus / Q000648:ultrastructure / Q000821:virology; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D056945:Hep G2 Cells; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008854:Microscopy, Electron; D014774:Virulence / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000577:Amides; D000998:Antiviral Agents; D002208:Caproates; D003998:Dicarboxylic Acids; D007093:Imidazoles; C539419:pentanedioic acid imidazolyl ethanamide