title: [Preclinical trials of L-lysine-alpha-oxidase, an antitumor enzyme].
abstract: The effect of L-lysine-alpha-oxidase from a representative of the Trichoderma genus on the humoral immune response to protein antigens was studied. It was shown that repeated fife-fold intravenous administrations of L-lysine-alpha-oxidase in a dose of 35 U/kg had no depressive action on the humoral immunity. The enzyme had no suppressive effect on the delayed type hypersensitivity to xenogenous erythrocytes. The use of L-lysine-alpha-oxidase in a therapeutic dose or in a twice as higher dose had no reliable effect on the leukocyte migration capacity vs. the control.
authors.forename: V M
authors.initials: VM
authors.lastname: Podboronov
authors.forename: A E
authors.initials: AE
authors.lastname: Kuzovnikov
authors.forename: A K
authors.initials: AK
authors.lastname: Zaĭtseva
authors.forename: I P
authors.initials: IP
authors.lastname: Smirnova
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies / Q000097:blood / Q000276:immunology; D000917:Antibody Formation / Q000187:drug effects*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001215:Asparaginase / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli / Q000201:enzymology; D056724:Immunity, Humoral / Q000276:immunology*; D007114:Immunization; D007962:Leukocytes / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D010047:Ovalbumin / Q000276:immunology; D012756:Sheep; D014242:Trichoderma / Q000201:enzymology*
chemical_list: D000906:Antibodies; D000970:Antineoplastic Agents; D010047:Ovalbumin; D000594:Amino Acid Oxidoreductases; C041123:L-lysine oxidase; D001215:Asparaginase