title: Effects of docosahexaenoic Acid supplementation on blood pressure, heart rate, and serum lipids in Scottish men with hypertension and hypercholesterolemia.
abstract: To investigate the effects of daily supplementation with docosahexaenoic acid (DHA) on coronary heart disease risks in 38 middle-aged men with hypertension and/or hypercholesterolemia in Scotland, a five-week double-blind placebo-controlled dietary supplementation with either 2 g of DHA or active placebo (1 g of olive oil) was conducted. Percent composition of DHA in plasma phospholipids increased significantly in DHA group. Systolic and diastolic blood pressure and heart rate decreased significantly in DHA group, but not in placebo group. High-density lipoprotein cholesterol (HDL-C) increased significantly, and total cholesterol (TC)/HDL-C and non-HDL-C/HDL-C ratios decreased significantly in both groups. There was no change in TC and non-HDL-C. We conclude that 2 g/day of DHA supplementation reduced coronary heart disease risk factor level improving blood pressure, heart rate, and lipid profiles in hypertensive, hypercholesterolemic Scottish men who do not eat fish on a regular basis.
authors.affiliation: Laboratory of Preventive Nutritional Medicine, Research Institute for Production Development, Kyoto 606-0805, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Sagara
authors.forename: Marina
authors.initials: M
authors.lastname: Njelekela
authors.forename: Takanori
authors.initials: T
authors.lastname: Teramoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Taguchi
authors.forename: Mari
authors.initials: M
authors.lastname: Mori
authors.forename: Lesley
authors.initials: L
authors.lastname: Armitage
authors.forename: Nina
authors.initials: N
authors.lastname: Birt
authors.forename: Christopher
authors.initials: C
authors.lastname: Birt
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yamori