title: [Shrinkage dynamics of cystic craniopharyngeomas after Yttrium-90 colloid brachytherapy].
abstract: OBJECTIVE
  The aim of this study is to reveal the long-term effect of Yttrium-90 colloid radioisotope brachytherapy applied for the treatment of cystic craniopharyngiomas. To provide a mathematical expression that can describe the cyst reduction as a function of time in an accurate matter.
  
  
  METHODS
  Fourteen cystic craniopharyngiomas were selected for intracavital irradiation with stereotactically implanted beta-emitting radioisotope Yttrium-90 silicate colloid. The cumulative dose aimed at the inner surface of the cyst wall was ranging between 180-300 Gy. Volumes of the cysts were measured on image-fused control CT/MRI images for a 28-month period. Dose planning was done with our own software, while stereotactic calculations, volume calculations and image fusion were done with the BrainLab Target 1.19 software. Mathematical and statistical computations were carried out with the Matlab numeric computation and visualization software. To determine the volumes, the control images were fused with the planning images.
  
  
  RESULTS
  Relative volumes normalized with respect to the volume of cysts before irradation were determined from the patients' measured data, the mean values of volumes were calculated, then a polynomial was fitted to the mean values using the polynomial curve fitting method. We have found that the dynamics describing the reduction of cysts can be expressed mathematically by the polynomial V=93.627-18.091t + 1.473t2 - 0.054t3 + 0.0007t4, where "t" denotes the time in months passed after irradiation. The accuracy of our results was verified by correlating the predicted data with the measured ones.
  
  
  CONCLUSIONS
  Our long-term results support the view, that intracavitary Yttrium-90 irradiation is a non invasive and very effective method for treatment of craniopharyngioma cysts. The derived polynomial helps to 1. design the best treatment, 2. follow up patients' condition and 3. plan a reirradiation if necessary.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar, Budapest. kzsuzsa83@freemail.hu
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Kolumbán
authors.forename: Katalin
authors.initials: K
authors.lastname: Bálint
authors.forename: Jeno
authors.initials: J
authors.lastname: Julow
mesh_terms: D001918:Brachytherapy / Q000379:methods; D003102:Colloids / Q000627:therapeutic use; D003397:Craniopharyngioma / Q000473:pathology* / Q000532:radiotherapy*; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D003102:Colloids; D015021:Yttrium Radioisotopes