title: Construction of a structurally defined double-stranded DNA catenane.
abstract: Topologically interlocked structures like catenanes and rotaxanes are promising components for the construction of molecular machines and motors. Herein we describe the construction of double-stranded DNA catenanes for DNA nanotechnology. For this, C-shaped DNA minicircle fragments were equipped with sequence-specific DNA-binding polyamides and their respective binding site. Formation of catenanes is achieved by self-assembly of two of these fragments and subsequent addition of a ring-closing oligonucleotide.
authors.affiliation: Cluster of Excellence Macromolecular Complexes, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt/M, Germany.
authors.forename: Thorsten L
authors.initials: TL
authors.lastname: Schmidt
authors.forename: Alexander
authors.initials: A
authors.lastname: Heckel
mesh_terms: D003460:Crystallization / Q000379:methods*; D043864:DNA, Catenated / Q000138:chemical synthesis* / Q000648:ultrastructure*; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size
chemical_list: D043864:DNA, Catenated