title: New immunosuppressive reagents to aid the induction of tolerance in organ graft recipients.
abstract: Thirty years ago when the first immunosuppressive agents became available for clinical grafting, the procedure was regarded with great skepticism by the medical profession as a pastime for ignorant surgeons with results that at best were poor. With the introduction of cyclosporin 15 years ago, the results of organ transplantation improved, and for the first time it was possible to transplant lung and pancreas with a reasonable outcome. Now more than 200,000 organ grafts have been performed worldwide and the procedure is an important established part of therapeutic surgery.
authors.affiliation: Professor of Surgery, Department of Surgery, Addenbrooke's Hospital, Cambridge, England.
authors.forename: S R
authors.initials: SR
authors.lastname: Calne
authors.forename: S
authors.initials: S
authors.lastname: Metcalfe