title: Gpc-3 is a notable diagnostic, prognostic and a latent targeted therapy marker in hepatocellular carcinoma.
abstract: OBJECTIVE
  To describe the features of the Gpc-3, explore the significance and value about the role of Gpc-3 in pathological diagnosis and prognostic evaluation of hepatocellular carcinoma.
  
  
  METHODS
  Take an overview of Gpc-3 expression in hepatocellular carcinoma and its expression of the relationship between the clinicopathological features of hepatocellular carcinoma, analysis the expression of Gpc-3 in liver cell adenoma, heterosexual hyperplasia and hepatitis C.
  
  
  RESULTS
  The expression of GPC-3 has a certain amount of specificity and sensitivity in hepatocellular carcinoma.
  
  
  CONCLUSIONS
  Gpc-3 is not only a diagnostic and prognostic marker in hepatocellular carcinoma, but also is expected to be an ideal target for the therapy of hepatocellular carcinoma.
authors.affiliation: The Center of Diagnosis and Treatment for Liver Diseases in Yantai City (The Infectious Diseases Hospital in Yantai), HuanShan Road 62, Yantai City 264001, ShanDong Province, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Zou
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Ding
authors.forename: Bo
authors.initials: B
authors.lastname: Long
authors.forename: Ji-Guang
authors.initials: JG
authors.lastname: Yuh
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Xu
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Lang
authors.forename: Sai-Ying
authors.initials: SY
authors.lastname: Zou
authors.forename: You-De
authors.initials: YD
authors.lastname: Liu
authors.forename: Kun
authors.initials: K
authors.lastname: Ding
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Li
mesh_terms: D000236:Adenoma / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D049109:Cell Proliferation; D053673:Glypicans / Q000032:analysis* / Q000235:genetics; D006526:Hepatitis C / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C105937:GPC3 protein, human; D053673:Glypicans