title: Contribution of early glycemic status in the development of severe retinopathy of prematurity in a cohort of ELBW infants.
abstract: OBJECTIVE
  The objective of this study is to investigate the relationship between glycemic status and severe retinopathy of prematurity (ROP).
  
  
  METHODS
  This is a retrospective cohort study of 114 infants <1000 g admitted to a level IV neonatal intensive care unit within 48 h of life. A cumulative, time-weighted glucose level (TWGL) derived from plotting glucose values over time was included in logistic regression analysis to identify predictors for severe ROP.
  
  
  RESULTS
  Infants had 26.6 ± 2 weeks gestational age and had a birth weight of 782 ± 136 g. TWGL during first 10 and 30 days of life were greater in the severe ROP group (P<0.01). Unlike single events of glucose levels ≥ 150 mg dl(-1), 10 days TWGL ≥ 100 mg dl(-1) (odds ratio (OR) 5.2, P<0.02) and 30 days TWGL ≥ 118 mg dl(-1) (OR 5.7, P<0.02) were predictors for severe ROP (univariate). Multivariate regression confirmed 30 days TWGL ≥ 118 mg dl(-1) (OR 9.4 to 10) and gram-positive sepsis (OR 4.1 to 5) as predictors for severe ROP (P<0.05).
  
  
  CONCLUSIONS
  High overall glycemic status is associated with the development of severe ROP.
authors.affiliation: Department of Pediatrics, Texas Tech University Health Sciences Center, Odessa, TX 79763, USA. r.chavez-valdez@ttuhsc.edu
authors.forename: R
authors.initials: R
authors.lastname: Chavez-Valdez
authors.forename: J
authors.initials: J
authors.lastname: McGowan
authors.forename: E
authors.initials: E
authors.lastname: Cannon
authors.forename: C U
authors.initials: CU
authors.lastname: Lehmann
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012178:Retinopathy of Prematurity / Q000097:blood* / Q000150:complications / Q000628:therapy
chemical_list: D001786:Blood Glucose