title: [Relationship between allergic symptoms and RORC2 and IL-17 in patients with allergic rhinitis].
abstract: OBJECTIVE
  To evaluate the relationship between allergic symptoms and retinoic acid-related orphan receptor variant 2 (RORC2) and interleukin (IL) 17 in patients with allergic rhinitis (AR).
  
  
  METHODS
  Blood sample, nasal secretion and nasal mucosa were taken from 23 patients with AR and 16 health individuals. The expression of RORC2 and IL-17 were detected by immunohistochemistry and quantitative real-time fluorescence reverse polymerase chain reaction. The allergic symptoms in patients were graded.
  
  
  RESULTS
  The rate of positive cells of RORC2 and IL-17 in AR group were 0.17 ± 0.05 and 0.72 ± 0.13, higher than the 0.05 ± 0.02 and 0.27 ± 0.11 of health controls, the difference was statistically significant (t were 9.51 and 11.92 respectively, all P < 0.05). The expression level of RORC2 mRNA in nasal mucosa and peripheral blood of AR group were 0.063 ± 0.011 and 0.452 ± 0.031, higher than the 0.029 ± 0.009 and 0.239 ± 0.027 of health controls, the difference was statistically significant (t were 6.51 and 3.35 respectively, all P < 0.05). The concentrations of IL-17 in the nasal mucosa, nasal secretions and serum levels of AR group were (70.28 ± 10.69), (45.32 ± 8.55) and (6.76 ± 1.18) pg/ml, compared with (18.43 ± 8.34), (6.83 ± 1.31) and (0.74 ± 0.05) pg/ml of controls, the difference was statistically significant (t were 7.92, 17.66 and 15.43 respectively, all P < 0.05). The allergy symptom scores of AR group were 9.43 ± 1.27. There were correlations between the allergic symptom and the expression of RORC2 mRNA and IL-17 in nasal mucosa and peripheral blood (r value were 0.820, 0.746, 0.629, 0.841 respectively, all P < 0.05).
  
  
  CONCLUSIONS
  RORC2 and IL-17 involved in the inflammatory response of AR and can be used as an indicator to judge the severity.
authors.affiliation: Otorhinolaryngology Hospital, First Affiliated Hospital of SUN Yet-san University, Guangzhou 510080, China.
authors.forename: Han-Gui
authors.initials: HG
authors.lastname: Lu
authors.forename: Hua
authors.initials: H
authors.lastname: Peng
authors.forename: De-Hua
authors.initials: DH
authors.lastname: Chen
authors.forename: Tian-Ying
authors.initials: TY
authors.lastname: Li
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Shi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D020381:Interleukin-17 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology*; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: D020381:Interleukin-17; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539900:RORC protein, human