title: Aerobic exercise has beneficial impact on atherogenic index of plasma in sedentary overweigh and obese women.
abstract: OBJECTIVE
  In obese patients, we hypothesized physical exercise (PE) to affect lipids through its intrahepatic fat accumulation-lowering effect, associated with a decrease of total body fat (Fat%) and even weight (Mass).
  
  
  METHODS
  Thirty seven sedentary, non-diabetic women (BMI median 34.8) from our out-patient department were tested. Elimination criteria: recent weight reduction, lipid-influencing or heart rate-modifying medication.
  
  
  METHODS
  50 entering, 37 finishing, 7 excluded for processing failure, 6 did not fulfill the protocol.
  
  
  METHODS
  PE protocol: 60 min supervised trainings, intensity at 65% of VO2max, modified by the clamp heart rate test. Median of total training hours was 34 during 115 days (median).
  
  
  METHODS
  an effect of PE on total cholesterol (CH), triglycerides (TG), HDL-cholesterol (HDL_C), LDL-cholesterol (LDL_C), index of atherogenity (IA), atherogenic index of plasma (AIP), maximum peak oxygen consumption (VO2max), Mass, body mass index (BMI), waist circumference (Waist) and Fat%.
  
  
  RESULTS
  Statistically significant differences at start (_s) and the end (_e) of PE (p<0.05): AIP -0.049, Mass -3.6 (kg), BMI -1.7 (kg/m2), Waist -2.5 (cm), Fat% -2.5, VO2max 2.92 (L.min-1kg-1). Correlation coefficients, Pearson's between Gaussian distributed (Gd-v) variables and Spearman´s (non Gd-v) statistically significant (p<0.05): IA and BMI, IA and Mass, IA and Waist, IA and Fat%, LDL and BMI, LDL and Mass, LDL and Fat%, LDL and Waist, IA and VO2max, LDL_C and VO2max.
  
  
  CONCLUSIONS
  PE improves lipid profile towards production of antiatherogenic particles more likely due to changes in anthropometric parameters than in improvement of physical fitness.
authors.affiliation: 3rd Department of Medicine, 1st Faculty of Medicine, Charles University and General Faculty Hospital in Prague, Czech Republic. zuzana.stranska@vfn.cz
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Stranska
authors.forename: Martin
authors.initials: M
authors.lastname: Matoulek
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Vilikus
authors.forename: Stepan
authors.initials: S
authors.lastname: Svacina
authors.forename: Pravoslav
authors.initials: P
authors.lastname: Stransky
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000378:metabolism* / Q000503:physiopathology*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology*; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides