title: Atrial structural remodeling in patients with atrial chronic fibrillations and in animal models.
abstract: Arrhythmia's atrium fibrillation (AF) is the most often met in clinical setting and it is associated with an increased in mortality risk. For profound the structural changes in chronic AF, we are studied the morphological changes of atrium biopsies to be effected at 175 patients. With sustained AF malformative and valvular acquired cardiac diseases operated under extracorporeal circulation. Similar studies we are effected to 11 dogs with partial coronary obstructions to a made periodical EKG investigations. The morphological changes mainly concern accommodation (dedifferentiation) of cardiomyocytes (particularly at experimental model) and mal-accommodation (degeneration of cells with fibrosis replacement features) particularly in acquired valvular diseases. These changes were often interfered. Over study, maintain the hypothesis that the structural changes to be an accommodation more than degenerative response to AF.
authors.affiliation: "Victor Babeş" National Institute, Bucharest, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Laky
authors.forename: Liliana
authors.initials: L
authors.lastname: Parascan
authors.forename: V
authors.initials: V
authors.lastname: Cândea
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D002908:Chronic Disease; D054059:Coronary Occlusion / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology* / Q000648:ultrastructure; D006351:Heart Valves / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008247:Lysosomes / Q000473:pathology / Q000648:ultrastructure; D008928:Mitochondria / Q000473:pathology / Q000648:ultrastructure; D009210:Myofibrils / Q000473:pathology / Q000648:ultrastructure; D014463:Ultrasonography