title: Organ printing: from bioprinter to organ biofabrication line.
abstract: Organ printing, or the layer by layer additive robotic biofabrication of functional three-dimensional tissue and organ constructs using self-assembling tissue spheroid building blocks, is a rapidly emerging technology that promises to transform tissue engineering into a commercially successful biomedical industry. It is increasingly obvious that similar well-established industries implement automated robotic systems on the path to commercial translation and economic success. The use of robotic bioprinters alone however is not sufficient for the development of large industrial scale organ biofabrication. The design and development of a fully integrated organ biofabrication line is imperative for the commercial translation of organ printing technology. This paper presents recent progress and challenges in the development of the essential components of an organ biofabrication line.
authors.affiliation: Advanced Tissue Biofabrication Center, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA. mironovv@musc.edu
authors.forename: Vladimir
authors.initials: V
authors.lastname: Mironov
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kasyanov
authors.forename: Roger R
authors.initials: RR
authors.lastname: Markwald
mesh_terms: D021522:Bioartificial Organs; D019149:Bioreactors; D006801:Humans; D012371:Robotics; D023822:Tissue Engineering / Q000295:instrumentation