title: Visceral adipocyte hypertrophy is associated with dyslipidemia independent of body composition and fat distribution in women.
abstract: OBJECTIVE
  We assessed whether subcutaneous and omental adipocyte hypertrophy are related to metabolic alterations independent of body composition and fat distribution in women.
  
  
  METHODS
  Mean adipocyte diameter of paired subcutaneous and omental adipose tissue samples was obtained in lean to obese women. Linear regression models predicting adipocyte size in both adipose tissue depots were computed using body composition and fat distribution measures (n = 150). In a given depot, women with larger adipocytes than predicted by the regression were considered as having adipocyte hypertrophy, whereas women with smaller adipocytes than predicted were considered as having adipocyte hyperplasia.
  
  
  RESULTS
  Women characterized by omental adipocyte hypertrophy had higher plasma and VLDL triglyceride levels as well as a higher total-to-HDL cholesterol ratio compared with women characterized by omental adipocyte hyperplasia (P < 0.05). Conversely, women characterized by subcutaneous adipocyte hypertrophy or hyperplasia showed a similar lipid profile. In logistic regression analyses, a 10% enlargement of omental adipocytes increased the risk of hypertriglyceridemia (adjusted odds ratio [OR] 4.06, P < 0.001) independent of body composition and fat distribution measures. A 10% increase in visceral adipocyte number also raised the risk of hypertriglyceridemia (adjusted OR 1.55, P < 0.02). Associations between adipocyte size and homeostasis model assessment of insulin resistance were not significant once adjusted for adiposity and body fat distribution.
  
  
  CONCLUSIONS
  These results suggest that omental, but not subcutaneous, adipocyte hypertrophy is associated with an altered lipid profile independent of body composition and fat distribution in women.
authors.affiliation: Endocrinology and Genomics, Laval University Medical Research Center, Québec, Canada.
authors.forename: Alain
authors.initials: A
authors.lastname: Veilleux
authors.forename: Maude
authors.initials: M
authors.lastname: Caron-Jobin
authors.forename: Suzanne
authors.initials: S
authors.lastname: Noël
authors.forename: Philippe Y
authors.initials: PY
authors.lastname: Laberge
authors.forename: André
authors.initials: A
authors.lastname: Tchernof
mesh_terms: D017667:Adipocytes / Q000473:pathology*; D000273:Adipose Tissue / Q000473:pathology*; D050154:Adiposity; D000328:Adult; D000368:Aged; D001823:Body Composition / Q000502:physiology*; D050171:Dyslipidemias / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism* / Q000473:pathology; D016014:Linear Models; D050356:Lipid Metabolism / Q000502:physiology; D016015:Logistic Models; D008875:Middle Aged; D014781:Viscera / Q000473:pathology*