title: [Plasma catecholamines in consciousness recovery in patients with severe traumatic brain injury].
abstract: Changes in plasma noradrenalin (NA) and dopamine (DA) levels were evaluated in the stages of consciousness recovery in patients with severe traumatic brain injury with and without deep brain structure damage. Forty-eight patients (36 men and 12 women), aged from 12 to 56 (31,9±10,9) yeas, were enrolled in the study. Two variants of catecholamine (CA) changes were found: 1) a CA-dissociation that was oppositely directed to NA and DA changes was observed in unconsciousness; 2) a CA-dissociation (unidirectional NA and DA changes) that was observed after the restoration of consciousness. In patients with the damage of two frontal lobes and deep brain structures, CA-association periods were seen in the stage of mental confusion with psychomotor agitation or when the brain stem was damaged. The duration of CA-association was negatively correlated with the velocity, quality of consciousness recovery and outcomes evaluated by the Glasgow scale.
authors.forename: E V
authors.initials: EV
authors.lastname: Aleksandrova
authors.forename: O S
authors.initials: OS
authors.lastname: Zaĭtsev
authors.forename: V D
authors.initials: VD
authors.lastname: Tenedieva
authors.forename: A A
authors.initials: AA
authors.lastname: Potapov
authors.forename: N E
authors.initials: NE
authors.lastname: Zakharova
authors.forename: A D
authors.initials: AD
authors.lastname: Kravchuk
authors.forename: A V
authors.initials: AV
authors.lastname: Oshorov
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Sokolova
authors.forename: V A
authors.initials: VA
authors.lastname: Shukhraĭ
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Vorob'ev
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000097:blood* / Q000628:therapy*; D002395:Catecholamines / Q000097:blood*; D002648:Child; D003243:Consciousness; D004298:Dopamine / Q000097:blood; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D014474:Unconsciousness / Q000097:blood* / Q000628:therapy*; D055815:Young Adult
chemical_list: D002395:Catecholamines; D004298:Dopamine; D009638:Norepinephrine