title: [Clinicopathologic characteristics of HELLP-syndrome].
abstract: HELLP-syndrome is one of the most severe variants of liver failure in pregnancy. The incidence among pregnant patients is 0.5-0.9%, and in presence of severe preeclampsia and eclampsy the incidence is 10-20%. Pathogenesis of HELLP-syndrome has common features with pathogenesis of preeclampsia, DIC-syndrome and fatty hepatosis of pregnant, this is confirmed by pathomorphological changes of liver in women with HELLP-syndrome. Efficacy of conservative therapy (corticosteroids, magnesium sulphate, hypotensive therapy, hepatoprotectors) and disintoxication methods (plasmapheresis, MARS-therapy) is not evident. Difficulties of timely diagnosing, symptomatic nature of treatment, severity of complications lead to high rates of maternal (up to 25%) and perinatal (up to 34%) mortality. The only radical and efficient method of HELLP-syndrome treatment available is a timely delivery. That's why the revelation and consideration of the slightest clinical and laboratorial manifestations is very important in pregnancy.
authors.forename: A V
authors.initials: AV
authors.lastname: Kulikov
authors.forename: S V
authors.initials: SV
authors.lastname: Spirin
authors.forename: S I
authors.initials: SI
authors.lastname: Blauman
mesh_terms: D001167:Arteritis / Q000473:pathology; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000473:pathology; D005260:Female; D017359:HELLP Syndrome / Q000097:blood / Q000473:pathology / Q000628:therapy; D006801:Humans; D007679:Kidney Medulla / Q000473:pathology; D008099:Liver / Q000473:pathology; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D014599:Uterus / Q000098:blood supply