title: A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production.
abstract: A specific and sensitive fluorescence-based method was developed for the imaging of microbe-induced HOCl production. Furthermore, we demonstrate dual oxidase (DUOX)-mediated HOCl generation in the mucosa of live animals providing a novel insight into mucosal innate immunity.
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Chen
authors.forename: Kyung-Ah
authors.initials: KA
authors.lastname: Lee
authors.forename: Eun-Mi
authors.initials: EM
authors.lastname: Ha
authors.forename: Kyung Mi
authors.initials: KM
authors.lastname: Lee
authors.forename: You Yeong
authors.initials: YY
authors.lastname: Seo
authors.forename: Han Kyoung
authors.initials: HK
authors.lastname: Choi
authors.forename: Ha Na
authors.initials: HN
authors.lastname: Kim
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Chun-Seok
authors.initials: CS
authors.lastname: Cho
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Won-Jae
authors.initials: WJ
authors.lastname: Lee
authors.forename: Juyoung
authors.initials: J
authors.lastname: Yoon
mesh_terms: D000818:Animals; D018407:Bacterial Physiological Phenomena; D002470:Cell Survival; D004331:Drosophila melanogaster / Q000276:immunology / Q000382:microbiology; D005658:Fungi / Q000502:physiology*; D006801:Humans; D006997:Hypochlorous Acid / Q000378:metabolism*; D007113:Immunity, Innate; D007413:Intestinal Mucosa / Q000378:metabolism / Q000382:microbiology; D057054:Molecular Imaging / Q000379:methods*; D019255:NADPH Oxidases / Q000378:metabolism; D009504:Neutrophils / Q000166:cytology / Q000382:microbiology; D010588:Phagosomes / Q000378:metabolism; D012235:Rhodamines / Q000737:chemistry
chemical_list: D012235:Rhodamines; C505384:dual oxidase, Drosophila; D006997:Hypochlorous Acid; D019255:NADPH Oxidases