title: Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients.
abstract: BACKGROUND
  Suitable biomarkers associated with the development of delirium are still not known. Urinary proteomics has successfully been applied to identify novel biomarkers associated with various disease states, but its value has not been investigated in delirium patients.
  
  
  RESULTS
  In a prospective explorative study hyperactive delirium patients after cardiac surgery were included for urinary proteomic analyses. Delirium patients were matched with non-delirium patients after cardiac surgery on age, gender, severity of illness score, LOS-ICU, Euro-score, C-reactive protein, renal function and aorta clamping time. Urine was collected within 24 hours after the onset of delirium. Matrix-assisted laser desorption/ionisation-time of flight mass spectrometry (MALDI-TOF MS) was applied to detect differences in the urinary proteome associated with delirium in these ICU patients. We included 10 hyperactive delirium and 10 meticulously matched non-delirium post-cardiac surgery patients. No relevant differences in the urinary excretion of proteins could be observed.
  
  
  CONCLUSIONS
  We conclude that MALDI-TOF MS of urine does not reveal a clear hyperactive delirium proteome fingerprint in ICU patients.
  
  
  BACKGROUND
  Clinical Trial Register number: NCT00604773.
authors.affiliation: Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, P,O, Box 9101, Nijmegen, 6500HB, the Netherlands. m.vandenboogaard@ic.umcn.nl.
authors.forename: Mark
authors.initials: M
authors.lastname: van den Boogaard
authors.forename: Rachel Pl
authors.initials: RP
authors.lastname: van Swelm
authors.forename: Frans Gm
authors.initials: FG
authors.lastname: Russel
authors.forename: Suzanne
authors.initials: S
authors.lastname: Heemskerk
authors.forename: Johannes G
authors.initials: JG
authors.lastname: van der Hoeven
authors.forename: Rosalinde
authors.initials: R
authors.lastname: Masereeuw
authors.forename: Peter
authors.initials: P
authors.lastname: Pickkers