title: Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses.
abstract: It has recently been discovered that some forms of timing-dependent long-term depression (t-LTD) require presynaptic N-methyl-d-aspartate (NMDA) receptors. In this review, we discuss the evidence for the presence of presynaptic NMDA receptors at cortical synapses and their possible role in the induction of t-LTD. Two basic models emerge for the induction of t-LTD at cortical synapses. In one model, coincident activation of presynaptic NMDA receptors and CB1 receptors mediates t-LTD. In a second model, CB1 receptors are not necessary, and the activation of presynaptic NMDA receptors alone appears to be sufficient for the induction of t-LTD.
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford Oxford, UK.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rodríguez-Moreno
authors.forename: Abhishek
authors.initials: A
authors.lastname: Banerjee
authors.forename: Ole
authors.initials: O
authors.lastname: Paulsen