title: The prognostic value of the Glasgow coma scale, serum acetylcholinesterase and leukocyte levels in acute organophosphorus poisoning.
abstract: OBJECTIVE
  Organophosphate poisoning (OP) is a serious clinical condition that may sometimes be fatal. The aim of this study was to determine whether the Glasgow coma scale (GCS), and serum acetylcholinesterase and leukocyte levels have prognostic value in acute OP poisoning.
  
  
  METHODS
  Retrospective review of records of patients admitted to the intensive care unit of Selcuk University, Meram Medical Faculty, Emergency Department, Konya, Turkey, between January 2006 and January 2009.
  
  
  METHODS
  We studied acutely OP-poisoned patients admitted within 24 hours after OP exposure.
  
  
  RESULTS
  The mean age of the 25 patients was 37 years (range, 20-80 years). Three (12%) of the 25 patients (male-female ratio, 12:13) died. The mean GCS values of the patients who died were significantly lower compared to those of the group that survived (4 vs 11.7, respectively P<.05). While the mean serum acetylcholinesterase levels were lower in the patients who died, the difference in the mean serum acetylcholinesterase levels between the patients who died and the ones who survived was not statistically significant (3841 IU/L vs. 1768 IU/L, respectively).
  
  
  CONCLUSIONS
  Although serum cholinesterase values can be used in the quick diagnosis, their efficiency at predicting outcome in patients with OP poisoning has not been established. It has also been determined that serum leukocyte values have no prognostic value in OP poisoning, but GCS values have been found to be effective in predicting the outcome.
authors.affiliation: Department of Emergency Medicine, Meram Medical Faculty, Selcuk University, Konya, Turkey. basarcander@yahoo.com
authors.forename: Basar
authors.initials: B
authors.lastname: Cander
authors.forename: Ali
authors.initials: A
authors.lastname: Dur
authors.forename: Mesut
authors.initials: M
authors.lastname: Yildiz
authors.forename: Feridun
authors.initials: F
authors.lastname: Koyuncu
authors.forename: Abdullah Sadik
authors.initials: AS
authors.lastname: Girisgin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
authors.forename: Mehmet
authors.initials: M
authors.lastname: Okumus
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007362:Intensive Care Units; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning; D010575:Pesticides / Q000506:poisoning*; D011379:Prognosis; D012189:Retrospective Studies; D013534:Survival; D014421:Turkey; D055815:Young Adult
chemical_list: D010575:Pesticides; D000110:Acetylcholinesterase