title: Two new diterpenoids and other constituents from Isodon rubescens.
abstract: Two new ent-kaurene diterpenoids, 15α-acetoxyl-6,11α-epoxy-6α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7-olide (1), 15α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (2), together with ten known compounds (5-14) were isolated from the leaves of Isodon rubescens. Their structures were elucidated mainly by various spectroscopic techniques and finally confirmed by single-crystal X-ray diffraction. Compounds 1, 2, 8 and 12 were evaluated for their cytotoxicities against EC-1, U87, A549, MCF-7 and Hela cell lines.
authors.affiliation: Pharmacy College, Xinxiang Medical University, Xinxiang 453003, PR China.
authors.forename: Rui-Jie
authors.initials: RJ
authors.lastname: Xie
authors.forename: Fu-Lin
authors.initials: FL
authors.lastname: Yan
authors.forename: Guang-Fan
authors.initials: GF
authors.lastname: Hai
authors.forename: Rui-Jie
authors.initials: RJ
authors.lastname: Hou
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Ding
authors.forename: Yi-Xiao
authors.initials: YX
authors.lastname: Bai
mesh_terms: D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
chemical_list: C560659:15alpha-acetoxyl-6,11alpha-epoxy-6alpha-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7-olide; C560660:15alpha-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7alpha(6,11alpha)-diolide; D004224:Diterpenes; D045786:Diterpenes, Kaurane