title: Immunologic aspects of multiple sclerosis.
abstract: Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system characterized by demyelination and axonal loss. Genetic and environmental factors contribute to the risk of immune dysregulation in multiple sclerosis. The review focuses on the immunopathogenic role played by various lymphocyte subsets and their cytokine products in the onset and disease progression, and the role of regulatory immune cells in disease remission. The mechanism of action of approved and experimental therapies, and how these mechanisms support the immunopathogenesis paradigm, is also reviewed.
authors.affiliation: Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ, USA.
authors.forename: Sridhar
authors.initials: S
authors.lastname: Boppana
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ito
authors.forename: Suhayl
authors.initials: S
authors.lastname: Dhib-Jalbut
mesh_terms: D001369:Axons / Q000276:immunology / Q000473:pathology; D018450:Disease Progression; D004777:Environment; D020022:Genetic Predisposition to Disease; D006801:Humans; D007109:Immunity / Q000187:drug effects / Q000235:genetics; D007155:Immunologic Factors / Q000276:immunology / Q000627:therapeutic use; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D009186:Myelin Sheath / Q000276:immunology / Q000473:pathology; D009410:Nerve Degeneration / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D035703:Therapies, Investigational
chemical_list: D007155:Immunologic Factors