title: The mouse cytomegalovirus glycoprotein m155 inhibits CD40 expression and restricts CD4 T cell responses.
abstract: Cytomegaloviruses (CMV) utilize a variety of immunomodulatory strategies to facilitate the establishment of lifelong persistence in their infected hosts. We show that the mouse CMV (MCMV) m155 open reading frame (ORF) is required for the posttranscriptional inhibition of CD40 expression in infected antigen-presenting cells. Consistent with the known importance of CD40-mediated costimulation of T cells, a m155-deficient virus induces enhanced MCMV epitope-specific CD4 T cell responses.
authors.affiliation: Division of Immune Regulation, The La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA.
authors.forename: Andrea I
authors.initials: AI
authors.lastname: Loewendorf
authors.forename: Lars
authors.initials: L
authors.lastname: Steinbrueck
authors.forename: Christoph
authors.initials: C
authors.lastname: Peter
authors.forename: Andreas
authors.initials: A
authors.lastname: Busche
authors.forename: Chris A
authors.initials: CA
authors.lastname: Benedict
authors.forename: Penelope C
authors.initials: PC
authors.lastname: Kay-Jackson
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D019013:CD40 Antigens / Q000037:antagonists & inhibitors*; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D018146:Muromegalovirus / Q000276:immunology* / Q000472:pathogenicity*; D014764:Viral Proteins / Q000276:immunology / Q000378:metabolism*
chemical_list: D019013:CD40 Antigens; D006023:Glycoproteins; D014764:Viral Proteins