title: Pulp repair after pulpotomy using different pulp capping agents: a comparative histologic analysis.
abstract: OBJECTIVE
  This study's purpose was to histologically evaluate the repair of rat tissue after pulpotomy and covering the pulp tissue with Copaifera langsdorffi oil resin, green propolis extract, fibrin sponge and iodoform-based paste.
  
  
  METHODS
  Pulpotomies were performed in the maxillary and mandibular first molars of 21 Wistar rats (84 total teeth). The access cavities were sealed with Coltosol, and histological evaluations were performed at 24 hours, 15 days, and 30 days postoperatively.
  
  
  RESULTS
  For all experimental periods and materials, an inflammatory response constituted predominantly by neutrophils was observed, being of milder intensity for the Copaifera langsdorffii oil-resin group and more severe for the fibrin sponge group, which exhibited periapical microabscesses. Necrosis was observed in all groups, and its extension increased with time, except for teeth protected with Copaifera langsdorffii oil-resin. Formation of a mineralized tissue barrier in the pulp exposure area occurred only in the Copaifera langsdorffii oil-resin group. Other findings, such as vascular congestion, edema, and hemorrhage, were observed in all cases.
  
  
  CONCLUSIONS
  The inflammatory response was less severe, the area of pulp necrosis was smaller, and more frequent formation of a mineralized tissue barrier was noted after pulpotomy was performed with Copaifera langsdorffii oil-resin compared to the other materials tested.
authors.affiliation: Potiguar University, Natal, Rio Grande do Norte, Brazil.
authors.forename: Raimunda Vilmar Evangelista
authors.initials: RV
authors.lastname: Lima
authors.forename: Mabel Rodrigues Alves
authors.initials: MR
authors.lastname: Esmeraldo
authors.forename: Maria Goretti Freire
authors.initials: MG
authors.lastname: de Carvalho
authors.forename: Patrícia Teixeira
authors.initials: PT
authors.lastname: de Oliveira
authors.forename: Rejane Andrade
authors.initials: RA
authors.lastname: de Carvalho
authors.forename: Francisco Lopes
authors.initials: FL
authors.lastname: da Silva
authors.forename: Edja Maria Melo
authors.initials: EM
authors.lastname: de Brito Costa
mesh_terms: D000818:Animals; D003782:Dental Pulp / Q000502:physiology*; D003790:Dental Pulp Necrosis / Q000209:etiology; D003809:Dentin, Secondary / Q000378:metabolism; D007887:Fabaceae; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D006847:Hydrocarbons, Iodinated / Q000627:therapeutic use; D010482:Periapical Abscess / Q000209:etiology; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010938:Plant Oils / Q000627:therapeutic use*; D011429:Propolis / Q000627:therapeutic use; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use*; D011671:Pulpitis / Q000209:etiology; D011672:Pulpotomy / Q000009:adverse effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015718:Fibrin Tissue Adhesive; D006847:Hydrocarbons, Iodinated; D010936:Plant Extracts; D010938:Plant Oils; D057872:Pulp Capping and Pulpectomy Agents; D011429:Propolis; C010473:iodoform