title: Hypergammaglobulinemia in an SIV-infected rhesus macaque with a B-cell neoplasm with plasma cell differentiation.
abstract: An SIV-infected rhesus macaque presented with anemia, hypercalcemia, and hyperglobulinemia. Neoplastic round cells with plasma cell morphology infiltrated multiple organs and stained immunohistochemically positive for CD45, MUM1/IRF4, CD138, VS38C, and Kappa light chain and variably positive for CD20 and CD79a, consistent with a B-cell neoplasm with plasma cell differentiation.
authors.affiliation: Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Kramer
authors.forename: Brigitte E
authors.initials: BE
authors.lastname: Sanders-Beer
authors.forename: Yvette Edghill
authors.initials: YE
authors.lastname: Spano
authors.forename: Lowrey
authors.initials: L
authors.lastname: Rhodes
authors.forename: Keith G
authors.initials: KG
authors.lastname: Mansfield
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D005260:Female; D006942:Hypergammaglobulinemia / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D007952:Leukemia, Plasma Cell / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D010950:Plasma Cells / Q000473:pathology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications*; D015302:Simian Immunodeficiency Virus