title: [Ovarian carcinogenesis: recent and past hypotheses].
abstract: Ovarian carcinogenesis and the early stages of malignant transformation are limited because of the lack of a candidate precursor. There have been several proposed hypotheses: first, ovary and the ovarian surface epithelium and more recently observations have increasingly focused attention of the Fallopian tube. Moreover, molecular genetic analysis has designed two main pathways of tumorogenesis. In this review, we discuss the different and perhaps complementary hypotheses about ovarian carcinogenesis.
authors.affiliation: Département de chirurgie, centre Jean-Perrin, Clermont-Ferrand, France. chenegautier@yahoo.fr
authors.forename: G
authors.initials: G
authors.lastname: Chêne
authors.forename: F
authors.initials: F
authors.lastname: Penault-Llorca
authors.forename: I
authors.initials: I
authors.lastname: Raoelfils
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Bignon
authors.forename: I
authors.initials: I
authors.lastname: Ray-Coquard
authors.forename: P
authors.initials: P
authors.lastname: Seffert
authors.forename: J
authors.initials: J
authors.lastname: Dauplat
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology