title: Treatment of severe metastatic calcification and calciphylaxis in dialysis patients.
abstract: Metastatic calcification is a frequent complication encountered in patients undergoing maintenance dialysis and has a complex pathogenesis. It is often difficult to treat and is associated with high morbidity and mortality. Early recognition and prompt initiation of treatment is vital. Local wound care and aggressive metabolic control remain the cornerstones of the therapy. Various novel treatment strategies including sodium thiosulfate and hyperbaric oxygen therapy have been utilized and reviewed in this paper. The response rate to treatment is poor and prevention is the best approach.
authors.affiliation: Division of Nephrology, St. John Providence Health System, St. John Hospital and Medical Center, 22201 Moross Road, Suite 150, Detroit, MI 48236, USA.
authors.forename: Saurabh K
authors.initials: SK
authors.lastname: Goel
authors.forename: Keith
authors.initials: K
authors.lastname: Bellovich
authors.forename: Peter A
authors.initials: PA
authors.lastname: McCullough