title: Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats.
abstract: Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) ameliorated an aging-associated deficit in object recognition memory in rats when the injection was given immediately, but not 6h after training. NaB had no effect in younger rats with normal memory retention. The results indicate that HDACis can ameliorate aging-related memory impairments by influencing the early consolidation phase of memory formation.
authors.affiliation: Laboratory of Neuropharmacology and Neural Tumor Biology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Gustavo K
authors.initials: GK
authors.lastname: Reolon
authors.forename: Natasha
authors.initials: N
authors.lastname: Maurmann
authors.forename: Aline
authors.initials: A
authors.lastname: Werenicz
authors.forename: Vanessa A
authors.initials: VA
authors.lastname: Garcia
authors.forename: Nadja
authors.initials: N
authors.lastname: Schröder
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Wood
authors.forename: Rafael
authors.initials: R
authors.lastname: Roesler
mesh_terms: D000818:Animals; D002087:Butyrates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D056572:Histone Deacetylase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects*
chemical_list: D002087:Butyrates; D056572:Histone Deacetylase Inhibitors