title: Total synthesis of the G2/M DNA damage checkpoint inhibitor psilostachyin C.
abstract: A concise total synthesis of the G2/M DNA damage checkpoint inhibitor psilostachyin C is reported using a 1,4-addition-aldol condensation-ring-closing metathesis (RCM) strategy. Initial biological studies indicate that psilostachyin C could enhance the sensitivity of the HeLa cell toward camptothecin (CPT) treatment via the activation of the caspase-3 mediated apoptosis pathway.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Shanghui
authors.initials: S
authors.lastname: Tu
authors.forename: Shuguang
authors.initials: S
authors.lastname: Wen
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
authors.forename: Feng
authors.initials: F
authors.lastname: Shao
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Lei
mesh_terms: D002455:Cell Division / Q000187:drug effects* / Q000235:genetics*; D004249:DNA Damage; D016195:G2 Phase / Q000187:drug effects* / Q000235:genetics*; D006367:HeLa Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D011753:Pyrones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D006575:Heterocyclic Compounds, 3-Ring; D011753:Pyrones; C560366:psilostachyin C