title: Upregulation of microparticles in DIC and its impact on inflammatory processes.
abstract: Disseminated intravascular coagulation (DIC) results in the catastrophic simultaneous activation of thrombotic and hemorrhagic processes. Its pathophysiology and the role of inflammation and microparticles (MPs) are not fully understood. Microparticles represent small phospholipid-expressing procoagulant vesicular fragments, released with cellular disruption and apoptosis. Functional MPs were measured in 100 random patients from a population of patients with DIC. Plasma samples from 30 normal male and female volunteers were used as control. Commercial Annexin trapping method was used to determine procoagulant activity of MPs. Mean ± SD concentration of MPs in the DIC group was 24.6 ± 14.2 nmol/L (range: 0.0-60.0 nmol/L), significantly higher than the control group: 8.5 ± 4.3 nmol/L (range: 1.3-17.4 nmol/L). Distribution curves and scattergrams showed that MPs concentration in the DIC samples was more widespread. This demonstrates that MPs are upregulated in patients with DIC and may mediate the hemostatic activation and inflammatory responses in this syndrome.
authors.affiliation: Loyola University Medical Center, 2160 South 1st Ave, Maywood, IL, USA. srahma2@lumc.edu
authors.forename: Saudur
authors.initials: S
authors.lastname: Rahman
authors.forename: Mark
authors.initials: M
authors.lastname: Cichon
authors.forename: Debra
authors.initials: D
authors.lastname: Hoppensteadt
authors.forename: Josephine
authors.initials: J
authors.lastname: Cunanan
authors.forename: Walter
authors.initials: W
authors.lastname: Jeske
authors.forename: Indermohan
authors.initials: I
authors.lastname: Thethi
authors.forename: Jawed
authors.initials: J
authors.lastname: Fareed
mesh_terms: D000328:Adult; D055252:Cell-Derived Microparticles / Q000378:metabolism* / Q000473:pathology*; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000473:pathology*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology; D008297:Male; D010976:Platelet Count; D015854:Up-Regulation
chemical_list: D005338:Fibrin Fibrinogen Degradation Products