title: Tetraspanin CD9 in cell migration.
abstract: Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activation of phosphoinositide 3-kinase, p38 MAPK (mitogen-activated protein kinase) and JNK (c-Jun N-terminal kinase). In the present paper, we describe a novel mechanism whereby CD9 specifically controls localization of talin1, one of the critical regulators of integrin activation, to focal adhesions: CD9-deficiency leads to impaired localization of talin1 to focal adhesions and correlates with increased motility of breast cancer cells.
authors.affiliation: School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
authors.forename: Dale
authors.initials: D
authors.lastname: Powner
authors.forename: Petra M
authors.initials: PM
authors.lastname: Kopp
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Monkley
authors.forename: David R
authors.initials: DR
authors.lastname: Critchley
authors.forename: Fedor
authors.initials: F
authors.lastname: Berditchevski
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D002465:Cell Movement / Q000235:genetics* / Q000502:physiology; D049109:Cell Proliferation; D005260:Female; D022001:Focal Adhesions / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016608:Talin / Q000378:metabolism; D060245:Tetraspanin 29
chemical_list: D015703:Antigens, CD; C554869:CD9 protein, human; D016023:Integrins; D008562:Membrane Glycoproteins; C518832:TLN1 protein, human; D016608:Talin; D060245:Tetraspanin 29