title: A new algorithm for the management of stable coronary artery disease incorporating CT coronary angiography and fractional flow reserve: how we can improve outcomes and reduce costs.
abstract: Computed tomography coronary angiography is the most reliable diagnostic test for coronary atherosclerosis. Stress testing should be reserved for diagnosis of myocardial ischaemia. Revascularisation, either by stenting or bypass grafts, is commonly performed in patients with stable coronary artery disease but is a double-edged sword. In the presence of ischaemia, revascularisation improves outcomes; in its absence, outcomes are worsened. In current practice, the decision of whether to revascularise is mainly made on the basis of the angiographic appearance of the coronary lesion in question. Physiological assessment of coronary lesions by the use of a pressure wire and measurement of fractional flow reserve (FFR) often shows that lesions thought to be sufficiently severe to warrant stenting or bypass do not cause ischaemia. A recent randomised study has shown that using FFR measurements to guide coronary stenting resulted in a lower use of stents, decreased costs and superior outcomes at 2 years, compared with traditional angiographic assessment alone. We believe that changes to the methods of health reimbursement are needed in both the public and private health systems, to facilitate greater use of FFR measurement.
authors.affiliation: MonashHeart, Southern Health, Monash Medical Centre, Melbourne, VIC, Australia. richard.harper@med.monash.edu.au
authors.forename: Richard W
authors.initials: RW
authors.lastname: Harper
authors.forename: Brian S
authors.initials: BS
authors.lastname: Ko
mesh_terms: D000465:Algorithms; D017023:Coronary Angiography / Q000191:economics / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000191:economics / Q000503:physiopathology / Q000628:therapy*; D003365:Costs and Cost Analysis; D004562:Electrocardiography; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000503:physiopathology; D009204:Myocardial Revascularization / Q000379:methods; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome