title: Vascular and metabolic properties of manidipine.
abstract: The combination of renin-angiotensin system blockers with calcium channel blockers appears to be one of the most effective options for treating hypertension and diabetes.Nevertheless, not all calcium blockers behave in the same manner. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria. In addition,T-type channels are related to proliferation, inflammation,fibrosis, vasoconstriction and activation of the renin-angiotensin system. The inhibition of these factors could explain the non-haemodynamic effects of manidipine as compared to other blockers.
authors.affiliation: Dr. Negrín Gran Canaria University Hospital, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canarias, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Buset Ríos
authors.forename: F
authors.initials: F
authors.lastname: Rodríguez Esparragón
authors.forename: C
authors.initials: C
authors.lastname: Fernández-Andrade Rodríguez
authors.forename: J C
authors.initials: JC
authors.lastname: Rodríguez Pérez
mesh_terms: D000419:Albuminuria / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000378:metabolism* / Q000494:pharmacology*; D002318:Cardiovascular Diseases; D004095:Dihydropyridines / Q000494:pharmacology*; D006801:Humans; D007333:Insulin Resistance; D009578:Nitrobenzenes; D018384:Oxidative Stress / Q000187:drug effects*; D010879:Piperazines
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D009578:Nitrobenzenes; D010879:Piperazines; C054218:manidipine