title: Multidimensional x-space magnetic particle imaging.
abstract: Magnetic particle imaging (MPI) is a promising new medical imaging tracer modality with potential applications in human angiography, cancer imaging, in vivo cell tracking, and inflammation imaging. Here we demonstrate both theoretically and experimentally that multidimensional MPI is a linear shift-invariant imaging system with an analytic point spread function. We also introduce a fast image reconstruction method that obtains the intrinsic MPI image with high signal-to-noise ratio via a simple gridding operation in x-space. We also demonstrate a method to reconstruct large field-of-view (FOV) images using partial FOV scanning, despite the loss of first harmonic image information due to direct feedthrough contamination. We conclude with the first experimental test of multidimensional x-space MPI.
authors.affiliation: Department of Bioengineering, University of California, Berkeley, CA 94720, USA. goodwill@berkeley.edu
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Goodwill
authors.forename: Steven M
authors.initials: SM
authors.lastname: Conolly
mesh_terms: D000465:Algorithms; D000792:Angiography / Q000379:methods*; D004867:Equipment Design; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D058185:Magnetite Nanoparticles / Q000032:analysis*; D015336:Molecular Probe Techniques; D019047:Phantoms, Imaging; D059629:Signal-To-Noise Ratio
chemical_list: D058185:Magnetite Nanoparticles