title: 4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice.
abstract: Metastasis remains a formidable problem in malignant tumors. In this study, MTT assay revealed that 4-methyl-3-nitro-benzoic acid (MNBA) had no effect on cell viability and did not interfere with cell cycle in any breast cancer cell lines tested. However, treatment with MNBA on breast cancer cells can inhibit EGF-induced migration and chemotaxis in vitro. In vivo assay demonstrated that MNBA and Paclitaxel synergistically inhibited tumor growth and metastasis in breast cancer SCID mice xenografts. These results suggest that MNBA is a potent inhibitor cancer cell chemotaxis and may be developed into a novel anti-metastasis drug.
authors.affiliation: Tianjin Medical University, Cancer Institute and Hospital, Research Center of Basic Medical Sciences, Tianjin, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
authors.forename: Menghui
authors.initials: M
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: David J
authors.initials: DJ
authors.lastname: Blake
authors.forename: Xiaoni
authors.initials: X
authors.lastname: Kong
authors.forename: Xishan
authors.initials: X
authors.lastname: Hao
authors.forename: Ruifang
authors.initials: R
authors.lastname: Niu
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009579:Nitrobenzoates / Q000494:pharmacology*; D017239:Paclitaxel / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
chemical_list: C558412:4-methyl-3-nitrobenzoic acid; D000970:Antineoplastic Agents; D009579:Nitrobenzoates; D017239:Paclitaxel