title: [Murine models in blood transfusion: allo-immunization, hemolysis].
abstract: Mice represent an animal model that can be easily manipulated. Mice have been used to model many human diseases. This review addresses murine models of immunity directed against red blood cell antigens as well as models of antibody and non-antibody mediated hemolysis. These models allow for a better understanding of the side effects of transfusion, such as red blood cell allo-immunization and post-transfusional hemolytic reactions. They also help explore strategies to treat and prevent these side effects in ways that would not be available using clinical research alone.
authors.affiliation: EFS Île-de-France, 51, avenue Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France. maxime.desmarets@efs.sante.fr
authors.forename: M
authors.initials: M
authors.lastname: Desmarets
authors.forename: F
authors.initials: F
authors.lastname: Noizat-Pirenne
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000235:genetics; D000818:Animals; D001769:Blood / Q000276:immunology; D001793:Blood Preservation; D001798:Blood Proteins / Q000235:genetics / Q000276:immunology; D001803:Blood Transfusion; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D023281:Genomics; D006461:Hemolysis / Q000276:immunology; D006801:Humans; D007114:Immunization; D007249:Inflammation / Q000097:blood / Q000276:immunology; D007518:Isoantibodies / Q000276:immunology; D007519:Isoantigens / Q000276:immunology; D051379:Mice / Q000097:blood / Q000235:genetics / Q000276:immunology; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D023421:Models, Animal; D013045:Species Specificity; D065227:Transfusion Reaction
chemical_list: D001798:Blood Proteins; D007518:Isoantibodies; D007519:Isoantigens