title: Bayesian semiparametric meta-analysis for genetic association studies.
abstract: We present a Bayesian semiparametric model for the meta-analysis of candidate gene studies with a binary outcome. Such studies often report results from association tests for different, possibly study-specific and non-overlapping genetic markers in the same genetic region. Meta-analyses of the results at each marker in isolation are seldom appropriate as they ignore the correlation that may exist between markers due to linkage disequilibrium (LD) and cannot assess the relative importance of variants at each marker. Also such marker-wise meta-analyses are restricted to only those studies that have typed the marker in question, with a potential loss of power. A better strategy is one which incorporates information about the LD between markers so that any combined estimate of the effect of each variant is corrected for the effect of other variants, as in multiple regression. Here we develop a Bayesian semiparametric model which models the observed genotype group frequencies conditional to the case/control status and uses pairwise LD measurements between markers as prior information to make posterior inference on adjusted effects. The approach allows borrowing of strength across studies and across markers. The analysis is based on a mixture of Dirichlet processes model as the underlying semiparametric model. Full posterior inference is performed through Markov chain Monte Carlo algorithms. The approach is demonstrated on simulated and real data.
authors.affiliation: Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom. m.deiorio@imperial.ac.uk
authors.forename: Maria
authors.initials: M
authors.lastname: De Iorio
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Newcombe
authors.forename: Ioanna
authors.initials: I
authors.lastname: Tachmazidou
authors.forename: Claudio J
authors.initials: CJ
authors.lastname: Verzilli
authors.forename: John C
authors.initials: JC
authors.lastname: Whittaker
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D003198:Computer Simulation; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3 / Q000235:genetics; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000706:statistics & numerical data*; D006801:Humans; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D008390:Markov Chains; D015201:Meta-Analysis as Topic; D008957:Models, Genetic; D015233:Models, Statistical; D009010:Monte Carlo Method; D015999:Multivariate Analysis; D020521:Stroke / Q000201:enzymology / Q000235:genetics
chemical_list: D005819:Genetic Markers; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517376:PDE4D protein, human