title: Grandilodines A-C, biologically active indole alkaloids from Kopsia grandifolia.
abstract: Three new indole alkaloids (1-3), named grandilodines A-C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established using NMR and MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Wai-Sum
authors.initials: WS
authors.lastname: Yap
authors.forename: Chew-Yan
authors.initials: CY
authors.lastname: Gan
authors.forename: Yun-Yee
authors.initials: YY
authors.lastname: Low
authors.forename: Yeun-Mun
authors.initials: YM
authors.lastname: Choo
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Etoh
authors.forename: Masahiko
authors.initials: M
authors.lastname: Hayashi
authors.forename: Kanki
authors.initials: K
authors.lastname: Komiyama
authors.forename: Toh-Seok
authors.initials: TS
authors.lastname: Kam
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007624:KB Cells; D015394:Molecular Structure; D014750:Vincristine / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; C560043:grandilodine A; C560042:grandilodine B; C560044:grandilodine C; D014750:Vincristine