title: Mitochondrial injury in human acute carbon monoxide poisoning: the effect of oxygen treatment.
abstract: The best oxygen therapy for acute carbon monoxide poisoning (ACOP) remains unestablished. Reported mitochondrial complex IV (mtCIV) inhibition, together with carboxyhaemoglobin (COHb)-induced hypoxia, may influence acute clinical symptoms and outcome. To "mitochondrially" evaluate treatment efficacy, we correlated intoxication severity and symptoms with mitochondrial function (mtCIV activity) and oxidative stress (lipid peroxidation) in 60 poisoned patients and determined ACOP recovery depending on either normobaric or hyperbaric oxygen therapy along a 3-month follow-up. In the present article we positively evaluate mtCIV as a good marker of ACOP recovery, treatment effectiveness, and late neurological syndrome development, which advocates for hyperbaric oxygen therapy as the treatment of choice. However, we discourage its usefulness as a severity marker because of its excessive sensitivity. We additionally evaluate oxidative stress role and prognostic factors for neurological sequelae development.
authors.affiliation: Mitochondrial Research Laboratory, Muscle Research Unit, IDIBAPS-University of Barcelona, Internal Medicine Department-Hospital Clinic of Barcelona, Barcelona, Spain. garrabou@clinic.ub.es
authors.forename: G
authors.initials: G
authors.lastname: Garrabou
authors.forename: J M
authors.initials: JM
authors.lastname: Inoriza
authors.forename: C
authors.initials: C
authors.lastname: Morén
authors.forename: G
authors.initials: G
authors.lastname: Oliu
authors.forename: Ò
authors.initials: Ò
authors.lastname: Miró
authors.forename: M J
authors.initials: MJ
authors.lastname: Martí
authors.forename: F
authors.initials: F
authors.lastname: Cardellach
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000393:Air Pollutants / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D002248:Carbon Monoxide / Q000633:toxicity*; D002249:Carbon Monoxide Poisoning / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors / Q000378:metabolism; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008928:Mitochondria / Q000187:drug effects*; D018384:Oxidative Stress; D010102:Oxygen Inhalation Therapy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000393:Air Pollutants; D015415:Biomarkers; D002248:Carbon Monoxide; D003576:Electron Transport Complex IV