title: Hemodialysis-associated pseudoporphyria resistant to N-acetylcysteine.
abstract: We report a 33-year-old female patient who had hemodialysis-associated pseudoporphyria which did not respond to treatment with oral N-acetylcysteine. She responded favorably to treatment with the anti-malarial drug, chloroquine. The case is being reported to highlight the difficulty in interpreting the urinary porphyrin assays in patients on hemodialysis. Additionally, the current literature on pseudoporphyria disorders in patients with end-stage renal disease is briefly discussed.
authors.affiliation: Service of Nephrology, Haemodialysis and Kidney Transplantation, Military Hospital, Mohammed V, Rabat, Morocco. delkabbaj@yahoo.fr
authors.forename: Driss
authors.initials: D
authors.lastname: El Kabbaj
authors.forename: Aziza
authors.initials: A
authors.lastname: Laalou
authors.forename: Zoubida
authors.initials: Z
authors.lastname: Alouane
authors.forename: Abdellali
authors.initials: A
authors.lastname: Bahadi
authors.forename: Zouhir
authors.initials: Z
authors.lastname: Oualim
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000328:Adult; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D011164:Porphyrias / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006435:Renal Dialysis / Q000009:adverse effects*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D017211:Treatment Failure
chemical_list: D002738:Chloroquine; D000111:Acetylcysteine