title: [Pharmacokinetics of the proton pump inhibitors and psychological status in patients as factors that influence the efficiency of treatment of GERD with pantoprazole].
abstract: Was made an investigation of the effectiveness of pantoprazole (sanpraz, "SanFarma", India) at gastroesophageal reflux disease (GERD). 53 patients with GERD, including 20--with reflux esophagitis, received a daily dose of pantoprazole 40 mg to 28 days. To the 7 day of treatment heartburn was broke in 63.3%, regurgitation--in 65% of patients initially experiencing these symptoms. The 14-th day of treatment heartburn was broke in 83.7%, regurgitation--in 90%. Endoscopic remission in 28-th day of treatment was obtained in 85% of patients with reflux esophagitis. Broking of symptoms was accompanied by significant improvement in well-being and quality of life of patients. Treatment of a standard dose of pantoprazole was ineffective in 16.3% of patients. The reasons for the conservation of heartburn in 4.1% of the cases was an individual characteristics of the pharmacokinetics drug, in 12.2%--non-reflux mechanisms of symptoms in the face of mental status.
authors.forename: D S
authors.initials: DS
authors.lastname: Bordin
authors.forename: A A
authors.initials: AA
authors.lastname: Masharova
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Sil'vestrova
authors.forename: L D
authors.initials: LD
authors.lastname: Firsova
authors.forename: O V
authors.initials: OV
authors.lastname: Safonova
authors.forename: A V
authors.initials: AV
authors.lastname: Petrakov
authors.forename: T S
authors.initials: TS
authors.lastname: Kozhurina
authors.forename: E R
authors.initials: ER
authors.lastname: Valitova
authors.forename: O B
authors.initials: OB
authors.lastname: Ianova
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000328:Adult; D001294:Attitude to Health; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D000077402:Pantoprazole; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D054328:Proton Pump Inhibitors; D000077402:Pantoprazole