title: Rare events in population genetics: stochastic tunneling in a two-locus model with recombination.
abstract: We study the evolution of a population in a two-locus genotype space, in which the negative effects of two single mutations are overcompensated in a high-fitness double mutant. We discuss how the interplay of finite population size N and sexual recombination at rate r affects the escape times t(esc) to the double mutant. For small populations demographic noise generates massive fluctuations in t(esc). The mean escape time varies nonmonotonically with r, and grows exponentially as lnt(esc)∼N(r-r(*))(3/2) beyond a critical value r(*).
authors.affiliation: Institut für Theoretische Physik, Universität zu Köln, D-50973 Köln, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Altland
authors.forename: Andrej
authors.initials: A
authors.lastname: Fischer
authors.forename: Joachim
authors.initials: J
authors.lastname: Krug
authors.forename: Ivan G
authors.initials: IG
authors.lastname: Szendro
mesh_terms: D056426:Genetic Loci / Q000235:genetics*; D008957:Models, Genetic; D011995:Recombination, Genetic / Q000235:genetics*; D013269:Stochastic Processes