title: Effects of early therapeutic administration of interleukin-1beta on survival rate and bone marrow haemopoiesis in irradiated mice.
abstract: The study was aimed at the experimental assessment of the efficacy of recombinant interleukin-1beta in the early therapy of haemopoiesis disorders caused by X-ray irradiation. The efficacy of the product was based on the 30-day survival rate and average life expectancy of dead animals. Endogenous and exogenous colony-formations were studied to reveal possible mechanisms of therapeutic effects of interleukin-1beta on the bone marrow. The early administration (10-15 min after exposure to radiation) of recombinant interleukin-1beta in a dose of 50 microg/kg increased the survival rate and prevented the post-irradiation decrease in the number of endogenous and exogenous CFU-S9 in irradiated mice.
authors.affiliation: Medical Military Academy, St. Petersburg, Russia. grebenyuk_an@mail.ru
authors.forename: Alexander
authors.initials: A
authors.lastname: Grebenyuk
authors.forename: Victor
authors.initials: V
authors.lastname: Zatsepin
authors.forename: Natalia
authors.initials: N
authors.lastname: Aksenova
authors.forename: Alexander
authors.initials: A
authors.lastname: Timoshevsky
mesh_terms: D000818:Animals; D006402:Hematologic Diseases / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D053583:Interleukin-1beta / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000008:administration & dosage*; D015996:Survival Rate
chemical_list: D053583:Interleukin-1beta; D011837:Radiation-Protective Agents; D011994:Recombinant Proteins