title: Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.
abstract: A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
authors.forename: Britta
authors.initials: B
authors.lastname: Schürmann
authors.forename: Birgitt
authors.initials: B
authors.lastname: Wiese
authors.forename: Horst
authors.initials: H
authors.lastname: Bickel
authors.forename: Siegfried
authors.initials: S
authors.lastname: Weyerer
authors.forename: Steffi G
authors.initials: SG
authors.lastname: Riedel-Heller
authors.forename: Michael
authors.initials: M
authors.lastname: Pentzek
authors.forename: Cadja
authors.initials: C
authors.lastname: Bachmann
authors.forename: Julie
authors.initials: J
authors.lastname: Williams
authors.forename: Hendrik
authors.initials: H
authors.lastname: van den Bussche
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Frank
authors.initials: F
authors.lastname: Jessen
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics*; D000704:Analysis of Variance; D051152:Clusterin / Q000097:blood* / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012307:Risk Factors
chemical_list: C495242:CLU protein, human; D051152:Clusterin