title: Two new compounds from an endophytic fungus Aspergillus sp. HS-05.
abstract: Two new compounds, N-[4'-hydroxy-(E)-cinnamoyl]-l-tyrosine methyl ester (1) and methyl 4-methoxy-3-(3'-hydroxy-2'-methyl)propionyloxy-benzoate (2), were isolated from EtOAc extract of the fermentation broth of the endophytic fungus Aspergillus sp. HS-05. Their structures were elucidated by NMR, IR, UV, MS, and CD methods. Compounds 1 and 2 showed no anticancer activities against HL-60 cell lines (both of IC(50)>100 μM) in vitro.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Hong-Hua
authors.initials: HH
authors.lastname: Wu
authors.forename: Xuan
authors.initials: X
authors.lastname: Lu
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
authors.forename: Xin
authors.initials: X
authors.lastname: Wu
authors.forename: Bo
authors.initials: B
authors.lastname: Pan
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
authors.forename: Jiao
authors.initials: J
authors.lastname: Bai
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001565:Benzoates; D004365:Drugs, Chinese Herbal; C558102:N-(4'-hydroxy-(E)-cinnamoyl)-L-tyrosine methyl ester; C558103:methyl 4-methoxy-3-(3'-hydroxy-2'-methyl)propionyloxybenzoate; C040444:tyrosine methyl ester; D014443:Tyrosine