title: Target-selective degradation of proteins and oligosaccharides by light-activated hybrid molecules for molecular-targeted photodynamic therapy.
abstract: Proteins and oligosaccharides are key players in many biological events. The development of novel methods for the selective degradation of targeted proteins and oligosaccharides has attracted much attention in the fields of chemistry, biology and medicine. Target-selective degradations of proteins, such as estrogen receptor-α androgen receptor and HIV-1 protease, by light-activated 2-phenylquinoline-steroid hormone hybrids, porphyrin derivatives and fullerene-sugar hybrids, and target-selective degradation of oligosaccharides, such as a T-antigen disaccharide, by a light-activated anthraquinone-lectin hybrid have been achieved. This novel class of light-activated and molecular-targeted molecules, namely molecular-targeted photosensitizers, promise bright prospects for finding not only molecular-targeted bioprobes for future application in the life sciences but also molecular-targeted drugs for future photodynamic therapy.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Toshima
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry; D000957:Antigens, Viral, Tumor / Q000737:chemistry / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000737:chemistry / Q000378:metabolism; D037741:Fullerenes / Q000737:chemistry / Q000378:metabolism; D016333:HIV Protease / Q000737:chemistry / Q000378:metabolism; D008027:Light; D008958:Models, Molecular; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D011804:Quinolines / Q000737:chemistry; D013256:Steroids / Q000737:chemistry
chemical_list: C541577:2-phenylquinoline; D000880:Anthraquinones; D000957:Antigens, Viral, Tumor; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D037741:Fullerenes; D009844:Oligosaccharides; D017319:Photosensitizing Agents; D011506:Proteins; D011804:Quinolines; D013256:Steroids; D016333:HIV Protease; C514803:p16 protease, Human immunodeficiency virus 1