title: Intestinal permeability, vitamin A absorption and serum alpha-tocopherol in gastrointestinal stromal tumor patients treated with imatinib.
abstract: Administration of imatinib is the therapy of choice in patients with advanced (inoperable) or metastatic gastrointestinal stromal tumors (GIST). Gastrointestinal toxicity is one of the most common side effects of anticancer therapy, including imatinib. Measurement of intestinal permeability represents a method of noninvasive laboratory assessment of gastrointestinal toxicity. We have measured intestinal permeability (by determining absorption of lactulose, mannitol and xylose), vitamin A absorption and serum alpha-tocopherol in 16 patients with advanced/metastatic GIST treated with imatinib. Lactulose/mannitol and lactulose/xylose ratios as well as parameters of vitamin A absorption did not change significantly during the treatment, but a significant decrease of alpha-tocopherol was observed. We conclude that, in contrast to most other anticancer agents studied so far, imatinib does not have an effect on intestinal permeability. No effect on vitamin A absorption was observed, but serum alpha-tocopherol decreased significantly during the treatment.
authors.affiliation: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic. bohuslav.melichar@fnol.cz
authors.forename: Bohuslav
authors.initials: B
authors.lastname: Melichar
authors.forename: Markéta
authors.initials: M
authors.lastname: Kašparová
authors.forename: Hana
authors.initials: H
authors.lastname: Kalábová
authors.forename: Josef
authors.initials: J
authors.lastname: Dvorák
authors.forename: Radomír
authors.initials: R
authors.lastname: Hyšpler
authors.forename: Alena
authors.initials: A
authors.lastname: Tichá
authors.forename: Lenka
authors.initials: L
authors.lastname: Krcmová
authors.forename: Jiří
authors.initials: J
authors.lastname: Plíšek
authors.forename: Petra
authors.initials: P
authors.lastname: Holecková
authors.forename: Dagmar
authors.initials: D
authors.lastname: Solichová
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001549:Benzamides; D019422:Dietary Sucrose / Q000493:pharmacokinetics*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D000068877:Imatinib Mesylate; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010539:Permeability; D010879:Piperazines / Q000494:pharmacology* / Q000627:therapeutic use; D011743:Pyrimidines / Q000494:pharmacology* / Q000627:therapeutic use; D014801:Vitamin A / Q000493:pharmacokinetics*; D024502:alpha-Tocopherol / Q000097:blood*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D019422:Dietary Sucrose; D010879:Piperazines; D011743:Pyrimidines; D014801:Vitamin A; D000068877:Imatinib Mesylate; D024502:alpha-Tocopherol