title: Clinical experiences derived from implementation of an easy to use concept for treatment of wound healing by secondary intention and guidance in selection of appropriate dressings.
abstract: The main objective of this case-cohort-type observational study conducted at different Surgical Departments of the Charité-Universitätsmedizin in Berlin was to evaluate the sequential use concept first described by Systagenix Wound Management in 2007. Fifty-two patients with different wound healing by secondary intention were treated for 7 weeks at the Charité-Universitätsmedizin in Berlin. A multidisciplinary team worked together to reach consensus in wound assessment; in classification of infection status according to the criteria described by European Wound Management Association (EWMA); in treatment protocol and on dressings to be used to 'cover' wounds. Before dressing application, all wounds were cleaned from debris. Following the sequential use concept, wounds classified as stages 2 and 3 were dressed with SILVERCEL(®) and TIELLE(®) or TIELLE PLUS(®) to 'clean' the wounds. After 2-3 weeks, treatment was changed to PROMOGRAN PRISMA(®) and TIELLE(®) to 'close and cover' wounds, thus providing optimal wound healing. Wounds classified as non infected were dressed with PROMOGRAN PRISMA(®) and TIELLE(®) during the complete treatment period. Patients were asked to evaluate the treatment using a simplified questionnaire developed at the Charité-Universitätsmedizin in Berlin. Wounds comprised 37 surgical procedures, 8 chronic mixed ulcer, 4 pressure sores, 1 diabetic foot ulcer, 1 venous leg ulcer, and 1 mixed arterial/venous ulcer. At baseline, 12 wounds were classified as stage 3, 38 wounds as stage 2 and 2 wounds as stage 1. After 7 weeks of treatment, all patients showed a positive clinical response to the sequential use treatment. Results of wound size showed a high significant progression of wound healing expressed with a profound reduction of wound area (P in all measurements <0·001, chi-square test) and improved granulation. This study summarises the clinical experiences derived from the evaluation of the sequential use concept in the daily clinical practice of wound treatment. On the basis of the wound healing results, patients' evaluation of treatment and the clinicians' and staff experiences, this concept was implemented at different Surgical Departments of the Charité-Universitätsmedizin in Berlin.
authors.affiliation: Department of General and Visceral Surgery, Campus Mitte, Charite-Universitaetsmedizin Berlin, Berlin, Germany. chris.braumann@charite.de
authors.forename: Chris
authors.initials: C
authors.lastname: Braumann
authors.forename: Nina
authors.initials: N
authors.lastname: Guenther
authors.forename: Charalambos
authors.initials: C
authors.lastname: Menenakos
authors.forename: Helga
authors.initials: H
authors.lastname: Muenzberg
authors.forename: Matthias
authors.initials: M
authors.lastname: Pirlich
authors.forename: Herbert
authors.initials: H
authors.lastname: Lochs
authors.forename: Joachim M
authors.initials: JM
authors.lastname: Mueller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages / Q000706:statistics & numerical data*; D001684:Biological Dressings / Q000706:statistics & numerical data; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002908:Chronic Disease; D015331:Cohort Studies; D003657:Decision Making; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006785:Hospitals, University; D006801:Humans; D020100:Hydrogels / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings / Q000706:statistics & numerical data; D018579:Patient Selection; D011182:Postoperative Care / Q000379:methods; D018570:Risk Assessment; D012720:Severity of Illness Index; D012883:Skin Ulcer / Q000175:diagnosis / Q000628:therapy; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000175:diagnosis / Q000601:surgery*; D055815:Young Adult
chemical_list: D020100:Hydrogels