title: Lipid metabolites in the pathogenesis and treatment of neovascular eye disease.
abstract: Lipids and lipid metabolites have long been known to play biological roles that go beyond energy storage and membrane structure. In age-related macular degeneration and diabetes, for example, dysregulation of lipid metabolism is closely associated with disease onset and progression. At the same time, some lipids and their metabolites can exert beneficial effects in the same disorders. This review summarises our current knowledge of the contributions of lipids to both the pathogenesis and treatment of neovascular eye disease. The clinical entities covered are exudative age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity, with a special emphasis on the potential therapeutic effects of ω3- (also known as n-3) polyunsaturated fatty acids.
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Stahl
authors.forename: Tim U
authors.initials: TU
authors.lastname: Krohne
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Sapieha
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Ann
authors.initials: A
authors.lastname: Hellstrom
authors.forename: Emily
authors.initials: E
authors.lastname: Chew
authors.forename: Frank G
authors.initials: FG
authors.lastname: Holz
authors.forename: Lois E H
authors.initials: LE
authors.lastname: Smith
mesh_terms: D003930:Diabetic Retinopathy / Q000188:drug therapy / Q000503:physiopathology; D005123:Eye / Q000098:blood supply*; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D050356:Lipid Metabolism / Q000502:physiology*; D015227:Lipid Peroxidation / Q000502:physiology; D008268:Macular Degeneration / Q000188:drug therapy / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000503:physiopathology*; D012178:Retinopathy of Prematurity / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D005231:Fatty Acids, Unsaturated