title: Genetic variation in complement component C3 shows association with ischaemic stroke.
abstract: OBJECTIVE
  The aim of this study was to investigate whether genetic variation at the third complement component (C3) locus is associated with ischaemic stroke (IS).
  
  
  METHODS
  The Sahlgrenska Academy Study on Ischaemic Stroke comprises 844 patients with IS, and 668 healthy controls. Sixteen SNPs were analyzed.
  
  
  RESULTS
  Two SNPs, rs2277984 and rs3745565, showed a significant association with overall IS. The SNP rs2277984 also showed association with the IS subtype cryptogenic stroke. These associations were independent of hypertension, diabetes, and smoking. The independent association between rs3745565 and overall IS withstands correction for multiple testing.
  
  
  CONCLUSIONS
  In this sample of patients with IS, genetic variation in C3 is associated with IS.
authors.affiliation: Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. sandra.olsson@neuro.gu.se
authors.forename: S
authors.initials: S
authors.lastname: Olsson
authors.forename: A
authors.initials: A
authors.lastname: Stokowska
authors.forename: L
authors.initials: L
authors.lastname: Holmegaard
authors.forename: K
authors.initials: K
authors.lastname: Jood
authors.forename: C
authors.initials: C
authors.lastname: Blomstrand
authors.forename: M
authors.initials: M
authors.lastname: Pekna
authors.forename: C
authors.initials: C
authors.lastname: Jern
mesh_terms: D002545:Brain Ischemia / Q000150:complications / Q000235:genetics* / Q000276:immunology*; D003176:Complement C3 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000502:physiology; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D020521:Stroke / Q000150:complications / Q000235:genetics* / Q000276:immunology*
chemical_list: D003176:Complement C3