title: fastsimcoal: a continuous-time coalescent simulator of genomic diversity under arbitrarily complex evolutionary scenarios.
abstract: BACKGROUND
  Genetic studies focus on increasingly larger genomic regions of both extant and ancient DNA, and there is a need for simulation software to match these technological advances. We present here a new coalescent-based simulation program fastsimcoal, which is able to quickly simulate a variety of genetic markers scattered over very long genomic regions with arbitrary recombination patterns under complex evolutionary scenarios.
  
  
  METHODS
  fastsimcoal is a C++ program compiled for Windows, MacOsX and Linux platforms. It is freely available at cmpg.unibe.ch/software/fastsimcoal/, together with its detailed user manual and example input files.
authors.affiliation: Institute of Ecology and Evolution, University of Berne, Berne, Switzerland. laurent.excoffier@iee.unibe.ch
authors.forename: Laurent
authors.initials: L
authors.lastname: Excoffier
authors.forename: Matthieu
authors.initials: M
authors.lastname: Foll
mesh_terms: D001499:Bayes Theorem; D005075:Biological Evolution; D003198:Computer Simulation; D005819:Genetic Markers; D023281:Genomics / Q000379:methods*; D008390:Markov Chains; D008957:Models, Genetic; D011995:Recombination, Genetic; D012984:Software
chemical_list: D005819:Genetic Markers