title: Measuring platelet aggregation in dialysis patients with a whole blood aggregometer by the screen filtration pressure method.
abstract: A semi-automatic, whole-blood aggregometer based on the screen filtration pressure (SFP) method is now widely used clinically and in research, but has not been used with hemodialysis (HD) patients. We measured whole-blood platelet aggregation in HD patients by the SFP method. This retrospective cross-sectional study included 62 HD patients, of whom 47 were non-diabetic and 15 were diabetic; we also included a control group of healthy, non-uremic subjects. With the t-test, we examined differences in the platelet aggregation threshold index (PATI) in meaningful sub-groupings of the HD patients, depending on whether or not they had diabetes, and whether or not they had been given antiplatelet agents. Considering the non-diabetic HD patients first, their PATI values were significantly higher than those values in the control subjects (3.1 [1.0-5.2] vs. 1.8 [1.3-2.3] µM, P<0.001). The non-diabetic HD patients taking antiplatelet agents showed significantly (1.9 times) higher PATI values than the non-diabetic HD patients without antiplatelet agents (4.4 [1.8-7.0] vs. 2.3 [1.3-3.3] µM, P=0.003). We observed similar trends among diabetic HD patients. Whole-blood analysis by the SPF method seems to be a promising way of monitoring platelet function for HD patients.
authors.affiliation: Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. kwaki-tky@umin.ac.jp
authors.forename: Kayo
authors.initials: K
authors.lastname: Waki
authors.forename: Aki
authors.initials: A
authors.lastname: Hayashi
authors.forename: Shigeo
authors.initials: S
authors.lastname: Ikeda
authors.forename: Sadao
authors.initials: S
authors.lastname: Ikeda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nagatsuka
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Honma
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
authors.forename: Sadayoshi
authors.initials: S
authors.lastname: Yoshinoya
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005260:Female; D005374:Filtration; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010979:Platelet Function Tests / Q000379:methods; D006435:Renal Dialysis; D012189:Retrospective Studies; D014511:Uremia / Q000628:therapy*
chemical_list: D010975:Platelet Aggregation Inhibitors