title: [Insulin sensitivity and beta cell function in female systemic lupus erythematosus patients].
abstract: OBJECTIVE
  To investigate insulin sensitivity and beta cell function in female systemic lupus erythematosus (SLE) patients with different glucose tolerances.
  
  
  METHODS
  Insulin sensitivity and beta cell function were compared between SLE patients and non-SLE subjects in the states of normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and diabetes mellitus (DM) respectively. Furthermore, risk factors for insulin sensitivity and beta cell function in SLE patients were analysed by linear regression.
  
  
  RESULTS
  In NGT state, insulin sensitivity and beta cell function of newly diagnosed SLE patients without glucocorticoids treatment were not significantly different from those of normal control group (P < 0.05). Compared with newly diagnosed SLE patients without glucocorticoids treatment and normal control group, HOMA insulin resistance index (HOMA-IR), ln (HOMA-β), ln (early phase insulin secretion index, EISI) and ln (late phase insulin secretion index, LISI) of SLE patients with glucocorticoids treatment were significantly higher (1.91 ± 1.04 vs 0.81 ± 0.75, 0.94 ± 0.27; 5.05 ± 0.65 vs 4.01 ± 0.63, 4.23 ± 0.47; 3.14 ± 0.81 vs 2.42 ± 0.39, 2.50 ± 0.65; 2.30 ± 0.55 vs 1.62 ± 0.57, 1.56 ± 0.43; P < 0.05), while ln (Matsuda index, MI) was significantly lower (4.53 ± 0.54 vs 5.27 ± 0.68, 5.18 ± 0.38; P < 0.05). In IGT and DM state, HOMA-IR (2.84 ± 1.87 vs 1.82 ± 1.22, 3.18 ± 2.29 vs 2.94 ± 2.26) and ln (HOMA-β) (5.18 ± 0.93 vs 4.06 ± 0.58, 3.99 ± 1.04 vs 3.43 ± 0.83) were significantly higher in SLE patients with glucocorticoids treatment than those of non-SLE subjects (P < 0.05) respectively. BMI and ln (daily glucocorticoids doses) were independent risk factors for insulin sensitivity, and age, the SLE disease activity index (SLEDAI) and ln (daily glucocorticoids doses) were related factors beta cell function.
  
  
  CONCLUSIONS
  In NGT, IGT and DM state, SLE female patients with glucocorticoids treatment have reduced insulin sensitivity and increased beta cell function, these changes are related to the use of glucocorticoids.
authors.affiliation: Department of Endocrinology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China. hcheng4374@21cn.com
authors.forename: Ying-juan
authors.initials: YJ
authors.lastname: Zeng
authors.forename: Fan-qin
authors.initials: FQ
authors.lastname: Zeng
authors.forename: Lie
authors.initials: L
authors.lastname: Dai
authors.forename: Chuan
authors.initials: C
authors.lastname: Yang
authors.forename: Bao-zhu
authors.initials: BZ
authors.lastname: Lin
authors.forename: Dong-hui
authors.initials: DH
authors.lastname: Zheng
authors.forename: Ci-wei
authors.initials: CW
authors.lastname: Liu
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Hua
authors.initials: H
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D018149:Glucose Intolerance / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000378:metabolism*; D008875:Middle Aged; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D007328:Insulin