title: Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease.
abstract: BACKGROUND
  The objective was to investigate associations between the HLA-A gene and Behcet's disease (BD) and its clinical manifestations.
  
  
  METHODS
  Genotyping for the HLA-A locus was performed using the polymerase chain reaction-Luminex typing method in 223 BD patients and 1,398 healthy controls.
  
  
  RESULTS
  The phenotypic frequencies of HLA-A*02:07 (odds ratio (OR) = 2.03, P = 0.002), A*26:01 (OR = 1.85, P = 0.008), and A*30:04 (OR = 2.51, P = 0.006) tended to be higher in BD patients than in normal controls, but the frequency of A*33:03 (OR = 0.59, P = 0.003) tended to be lower in BD patients. A meta-analysis adopting our and the Japanese data confirmed the associations of HLA-A*02:07, A*26:01, and A*33:03 with BD. Furthermore, the frequencies of the HLA-A*02:07, A*26:01, and A*30:04 were significantly higher in patients with skin lesions (OR = 2.37, P < 0.0005, Pc < 0.012) and arthritis (OR = 2.32, P = 0.002, Pc = 0.048), with uveitis (OR = 3.01, P < 0.0005, Pc < 0.012), and with vascular lesions (OR = 9.80, P < 0.0005, Pc < 0.012) and a positive pathergy test (OR = 4.10, P = 0.002, Pc = 0.048), respectively, than in controls. In HLA-B*51 non-carriers, these associations were also significant, being much stronger between HLA-A*26:01 and uveitis (OR = 4.19, P < 0.0005, Pc < 0.012) and between HLA-A*30:04 and vascular lesions (OR = 13.97, P < 0.00005, Pc < 0.0012). In addition, HLA-A*30:04 was associated with genital ulcers in HLA-B*51 non-carriers (OR = 3.89, P = 0.002, Pc = 0.048).
  
  
  CONCLUSIONS
  HLA-A*02:07, A*26:01, and A*30:04 were associated with increased risk for BD, while HLA-A*33:03 with decreased risk. HLA-A*02:07, A*26:01, and A*30:04 were associated with skin lesions and arthritis, with uveitis, and with vascular lesions, genital ulcers, and a positive pathergy test, respectively.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, 28 Yeongeon-dong, Jongno-gu, Seoul, Korea.
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Kang
authors.forename: Jeong Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Fujio
authors.initials: F
authors.lastname: Takeuchi
authors.forename: Joon Wan
authors.initials: JW
authors.lastname: Kim
authors.forename: Kichul
authors.initials: K
authors.lastname: Shin
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Lee
authors.forename: Yun Jong
authors.initials: YJ
authors.lastname: Lee
authors.forename: Eun Bong
authors.initials: EB
authors.lastname: Lee
authors.forename: Myoung Hee
authors.initials: MH
authors.lastname: Park
authors.forename: Yeong Wook
authors.initials: YW
authors.lastname: Song
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D015234:HLA-A Antigens