title: [Five-year follow up in patients after surgery for clear cell renal carcinoma].
abstract: OBJECTIVE
  Evaluation of the five-year follow-up of patients treated for clear-cell renal carcinoma in dependency on its characteristic and extension. PATIENTS' COHORT AND METHODS: Retrospective analysis of five-year follow-up of 269 patients treated for clear-cell renal carcinoma in dependency on T, N, M and clinical tumor stage; presence of lymphatic and distant metastases, cellular grade and tumor necrosis. Tumor-specific surviving is presented on Kaplan-Meier curves.
  
  
  RESULTS
  Five-year patients surviving with tumor T1, T2 and T3 were 91.8%, 70.7% and 34.6% respectively. Surviving patients without lymphatic metastases was 85%; with metastases was 6.9%. Surviving patients without distant metastases was 84.1%; with metastases was 0%. Surviving of patients with clinical tumor stage I, II, III and IV were 94.6%, 83.8%, 48.7% and 0% respectively. Surviving of patients with tumor cellular grade G1, G2, G3 and G4 were 87.5%, 95.5%, 64.2% and 27.6% respectively. Surviving patients without tumor necrosis was 92.4%; with metastases was 31.9%.
  
  
  CONCLUSIONS
  Tumor size and the presence of metastases are very significant factors to patient survival. Histological characteristics as a nuclear grade and a tumor necrosis have been important prognostic factors for the future of the patient. Early diagnosis and aggressive surgical treatment are the most important for the positive course of the disease.
authors.affiliation: Urologická klinika FN a LF UK v Hradci Králové. pacovsky@fnhk.cz
authors.forename: J
authors.initials: J
authors.lastname: Pacovský
authors.forename: J
authors.initials: J
authors.lastname: Kosina
authors.forename: L
authors.initials: L
authors.lastname: Holub
authors.forename: P
authors.initials: P
authors.lastname: Navrátil
authors.forename: P
authors.initials: P
authors.lastname: Husek
authors.forename: M
authors.initials: M
authors.lastname: Brod'ák
mesh_terms: D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate