title: Successful treatment of a bifocal eosinophilic granuloma of the spine with CT-guided corticosteroid injection.
abstract: Observation and immobilization is adequate for most patients with spinal eosinophilic granuloma; however, in patients with symptomatic lesions, treatment other than simple observation or biopsy alone is recommended. In view of the benign clinical course of eosinophilic granuloma, a simple, minimally invasive, outpatient treatment with a low complication rate such as computed tomography (CT)-guided intralesional corticosteroid injection may be considered the treatment of choice. This article presents a case of a 21-year-old man with a symptomatic bifocal eosinophilic granuloma at the vertebral body of the L3 vertebra and the left T5 costovertebral joint treated effectively by CT-guided intralesional methylprednisolone injection. To the best of our knowledge, this is the first case of successful treatment of a bifocal eosinophilic granuloma with CT-guided corticosteroid injection. Under general anesthesia and CT guidance, the lesion was located through the right transpedicular approach for the L3 lesion and the left posterolateral approach for the T5 lesion using a biopsy trocar. Tissue sample was retrieved and frozen section biopsy showed eosinophilic granuloma. One intralesional CT-guided injection of 80 mg (2 mL) of methylprednisolone acetate was performed in each lesion. Complications related to the procedure were not observed. The patient was admitted postprocedural for overnight medical evaluation and was discharged from the hospital the next day. Complete resolution of pain was observed 72 hours after the procedure. At 5 years after diagnosis and treatment, the patient is asymptomatic; imaging showed healing of both lesions.
authors.affiliation: Department of Orthopedics, University of Bologna, Bologna, Italy.
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Mavrogenis
authors.forename: Eugenio
authors.initials: E
authors.lastname: Rimondi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ussia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rossi
authors.forename: Pietro
authors.initials: P
authors.lastname: Ruggieri
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D004803:Eosinophilic Granuloma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007278:Injections, Spinal / Q000379:methods; D008297:Male; D015641:Radiography, Interventional / Q000379:methods*; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones