title: New insights into the function of transcription factor TFIID from recent structural studies.
abstract: The general transcription factor IID is a key player in the early events of gene expression. TFIID is a multisubunit complex composed of the TATA binding protein and at least 13 TBP associated factors (TAfs) which recognize the promoter of protein coding genes in an activator dependant way. This review highlights recent findings on the molecular architecture and dynamics of TFIID. The structural analysis of functional transcription complexes formed by TFIID, TFIIA, activators and/or promoter DNA illuminates the faculty of TFIID to adjust to various promoter architectures and highlights its role as a platform for preinitiation complex assembly.
authors.affiliation: Integrated Structural Biology Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), U964 Inserm, UMR7104 CNRS-Université de Strasbourg, 1 rue Laurent Fries, BP10142, 67404 Illkirch, France.
authors.forename: Gabor
authors.initials: G
authors.lastname: Papai
authors.forename: P Anthony
authors.initials: PA
authors.lastname: Weil
authors.forename: Patrick
authors.initials: P
authors.lastname: Schultz
mesh_terms: D000818:Animals; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D035362:Transcription Factor TFIID / Q000737:chemistry* / Q000378:metabolism
chemical_list: D021122:Protein Subunits; D035362:Transcription Factor TFIID