title: [Vascular endothelial function in salt sensitive and non-salt sensitive subjects].
abstract: OBJECTIVE
  Salt-sensitivity is associated with more severe target organ injury and higher mortality in patients with essential hypertension. We compared the vascular endothelial function between salt-sensitive subjects (SS) and non-salt-sensitive subjects (NSS) with normal or mildly increased blood pressure.
  
  
  METHODS
  Ninety-nine subjects (aged 16 - 60 years) with normal blood pressure or mild hypertension (degree 1) were enrolled. The test program included 3 days baseline investigation, 1 week low-salt loading phase and 1 week high-salt loading phase. Endothelial function was assessed by measuring the flow mediated dilatation (FMD) of the brachial artery using high resolution ultrasound.
  
  
  RESULTS
  There was 17.2% SS. Plasma NOx level [(61.2 ± 13.3) µmol/L vs (82.5 ± 14.6) µmol/L, P < 0.05] and FMD [(10.2 ± 2.5)% vs (14.5 ± 1.6)%, P < 0.05] were significantly lower in SS subjects than in NSS subjects.
  
  
  CONCLUSIONS
  Vascular endothelial dysfunction was evidenced in SS subjects with normal blood pressure or in the early stage of hypertension.
authors.affiliation: Department of Cardiology, Xi'an Jiaotong University, Xian 710061, China.
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Mu
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Liu
authors.forename: Zhi-quan
authors.initials: ZQ
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D016022:Case-Control Studies; D004727:Endothelium / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012982:Sodium, Dietary / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D012982:Sodium, Dietary