title: Pregabalin in zolpidem dependence and withdrawal.
abstract: Several recent reports attest to zolpidem's strong potential for abuse, dependence, and severe withdrawal symptoms upon its discontinuation. We report, for the first time, on 1 case of heavy zolpidem abuse and dependence with severe withdrawal symptoms twice treated safely and successfully with pregabalin, a newer antiepileptic agent devoid of known strong potential for abuse and dependence.
authors.affiliation: Athens University Medical School, First Department of Psychiatry, Eginition Hospital, Athens, Greece. oulisp@med.uoa.gr
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Oulis
authors.forename: George
authors.initials: G
authors.lastname: Nakkas
authors.forename: Vasilios G
authors.initials: VG
authors.lastname: Masdrakis
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D019263:Dysthymic Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008875:Middle Aged; D000069583:Pregabalin; D011725:Pyridines / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000209:etiology; D000077334:Zolpidem; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D011725:Pyridines; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000077334:Zolpidem