title: MrBayes on a graphics processing unit.
abstract: BACKGROUND
  Bayesian phylogenetic inference can be used to propose a 'tree of life' for a collection of species whose DNA sequences are known. While there are many packages available that implement Bayesian phylogenetic inference, such as the popular MrBayes, running these programs poses significant computational challenges. Parallelized versions of the Metropolis coupled Markov chain Monte Carlo (MC³) algorithm in MrBayes have been presented that can run on various platforms, such as a graphics processing unit (GPU). The GPU has been used as a cost-effective means for computational research in many fields. However, until now, some limitations have prevented the GPU from being used to run MrBayes MC³ effectively.
  
  
  RESULTS
  We give an appraisal of the possibility of realistically implementing MrBayes MC³ in parallel on an ordinary four-core desktop computer with a GPU. An earlier proposed algorithm for running MrBayes MC³ in parallel on a GPU has some significant drawbacks (e.g. too much CPU-GPU communication) which we resolve. We implement these improvements on the NVIDIA GeForce GTX 480 as most other GPUs are unsuitable for running MrBayes MC³ due to a range of reasons, such as having insufficient support for double precision floating-point arithmetic. Experiments indicate that run-time can be decreased by a factor of up to 5.4 by adding a single GPU (versus state-of-the-art multicore parallel algorithms). We can also achieve a speedup (versus serial MrBayes MC³) of more than 40 on a sufficiently large dataset using two GPUs.
  
  
  BACKGROUND
  GPU MrBayes (i.e. the proposed implementation of MrBayes MC³ for the GPU) is available from http://mrbayes-gpu.sourceforge.net/.
authors.affiliation: Nankai-Baidu Joint Laboratory, College of Information Technical Science, Nankai University, Tianjin, China.
authors.forename: Jianfu
authors.initials: J
authors.lastname: Zhou
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Liu
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Stones
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xie
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D001499:Bayes Theorem; D019295:Computational Biology / Q000379:methods*; D008390:Markov Chains; D009010:Monte Carlo Method; D010802:Phylogeny; D012984:Software