title: The efficacy of a 1-week triple therapy for eradication of Helicobacter pylori infection in children.
abstract: OBJECTIVE
  Poor compliance to therapy and antibiotic resistance are the main causes for failure of anti-Helicobacter pylori (H. pylori) therapy. The purpose of this study was to assess the effectiveness of omeprazole-based triple therapy in Iranian children.
  
  
  METHODS
  Fifty-seven children with H. pylori-related gastroduodenal disease received 1-week triple therapy with a combination of omeprazole, amoxicillin and clarithromycin (according to the susceptibility test). Success of eradication was assessed by (13)C-urea breath test and endoscopy.
  
  
  RESULTS
  Sixty-four patients (mean age 11.3years; range 2.7-16years) were included. Eradication was successful in 84.2% (95% confidence interval, 72.8% intention to treat).
  
  
  CONCLUSIONS
  One-week triple therapy was effective for the eradication of H. pylori infection in children.
authors.affiliation: Gastroenterology, Children Medical Center Hospital, Tehran, Iran. najafisa@sina.tums.ac.ir
authors.forename: Najafi
authors.initials: N
authors.lastname: Mehri
authors.forename: Eftekhari
authors.initials: E
authors.lastname: Kambiz
authors.forename: Khodadad
authors.initials: K
authors.lastname: Ahmad
authors.forename: Farahmand
authors.initials: F
authors.lastname: Fatemeh
authors.forename: Motamed
authors.initials: M
authors.lastname: Farzaneh
authors.forename: Fallahi Gholam
authors.initials: FG
authors.lastname: Hossein
authors.forename: Mahjoub
authors.initials: M
authors.lastname: Fatemeh
mesh_terms: D000293:Adolescent; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D001944:Breath Tests; D002648:Child; D002675:Child, Preschool; D017291:Clarithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole