title: [The biological functions of G-quadruplex].
abstract: G-quadruplex is a kind of special secondary structure of nuclei acids, which exists in genome DNA and RNA and preferentially located in functional regions such as telomeres, promoters, 5' untranslated region (5' UTR) of mRNA and so on. G-quadruplex has been implicated by a lot of studies as an important structure in many biological processes including gene stability, telomere synthesis, transcriptional or translational regulation of gene expression and recombination. We here review the recent studies of G-quadruplex in genome DNA, RNA and G-quadruplex oligonucleotides, focusing on their biological function.
authors.affiliation: Institute of Vascular Medicine, Peking University Third Hospital, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing 100191, China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Chen
authors.forename: Ming-He
authors.initials: MH
authors.lastname: Xiu
authors.forename: Su-Fang
authors.initials: SF
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics*; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D054856:G-Quadruplexes; D006801:Humans; D009841:Oligonucleotides / Q000235:genetics; D020871:RNA Stability; D016615:Telomere / Q000235:genetics / Q000378:metabolism
chemical_list: D020121:5' Untranslated Regions; D009841:Oligonucleotides; D004247:DNA