title: Use of peripheral blood transcriptome biomarkers for epilepsy prediction.
abstract: There are currently no predictive methods to identify patients who suffered an initial brain injury and are at high risk of developing chronic epilepsy. Consequently, treatments aimed at epilepsy prevention that would target the underlying epileptogenic process are neither available nor being developed. After a brain injury or any other initial precipitating event (IPE) to the development of epilepsy, pathological changes may occur in forms of inflammation, damage in the blood brain barrier, neuron loss, gliosis, axon sprouting, etc., in multiple brain areas. Recent studies provide connections between various kinds of brain pathology and alterations in the peripheral blood transcriptome. In this review we discuss the possibility of using peripheral blood transcriptome biomarkers for the detection of epileptogenesis and consequently, subjects at high risk of developing epilepsy.
authors.affiliation: Division of Neuroscience, Department of Neurology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90504, USA. skarsten@ucla.edu
authors.forename: Stanislav L
authors.initials: SL
authors.lastname: Karsten
authors.forename: Lili C
authors.initials: LC
authors.lastname: Kudo
authors.forename: Anatol J
authors.initials: AJ
authors.lastname: Bragin
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis*; D001921:Brain / Q000378:metabolism*; D004827:Epilepsy / Q000097:blood* / Q000175:diagnosis*; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D059467:Transcriptome
chemical_list: D015415:Biomarkers; D001798:Blood Proteins