title: Role of 18F-fluorodeoxyglucose positron emission tomography in the workup of retroperitoneal fibrosis.
abstract: Retroperitoneal fibrosis is a syndrome characterised by the presence of fibrosclerotic tissue in the retroperitoneum, often encasing the ureters. In most cases, retroperitoneal fibrosis is idiopathic, but may also be associated with large vessel vasculitis at distant sites, with the so-called IgG4-related sclerosing disease, as well as with exposure to some medications, infections, malignancies, surgery, or radiation. 18-Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a nuclear medicine technique which is able to accurately identify in vivo areas characterised by elevated glucose metabolism, such as inflammatory, infective, and neoplastic lesions. There is mounting evidence suggesting that FDG-PET may have a role in assessing disease activity in idiopathic retroperitoneal fibrosis, but the role of FDG-PET in secondary retroperitoneal fibrosis is less established. Herein, we present four patients with retroperitoneal fibrosis of different etiology (isolated idiopathic, associated with large-vessel involvement, associated with carcinoid tumour, and secondary to pergolide) who underwent FDG-PET as part of their workup. The implications of FGD-PET results in the diagnosis and treatment of retroperitoneal fibrosis of different etiology are discussed.
authors.affiliation: Rheumatology Department, Arcispedale Santa Maria Nuova, Viale Risorgimento 80, 42100 Reggio Emilia, Italy. pipitone.nicolo@asmn.re.it
authors.forename: Nicolo
authors.initials: N
authors.lastname: Pipitone
authors.forename: Annibale
authors.initials: A
authors.lastname: Versari
authors.forename: Augusto
authors.initials: A
authors.lastname: Vaglio
authors.forename: Carlo
authors.initials: C
authors.lastname: Salvarani
mesh_terms: D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011241:Prednisone / Q000008:administration & dosage; D019275:Radiopharmaceuticals; D012185:Retroperitoneal Fibrosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D011241:Prednisone