title: Genogroup I picobirnavirus in diarrhoeic foals: can the horse serve as a natural reservoir for human infection?
abstract: Picobirnaviruses (PBV) are small, non-enveloped viruses with a bisegmented double-stranded RNA genome. In this study a PBV strain, PBV/Horse/India/BG-Eq-3/2010, was identified in the faeces of a 10 month old weaned female foal with diarrhoea in January 2010 from Kolkata, India. Surprisingly, sequence comparison and phylogenetic analysis of a short stretch of the RNA dependent RNA polymerase gene revealed close genetic relatedness (> 98% nucleotide identity) to a human genogroup I PBV strain (Hu/GPBV1) detected earlier from the same part of India. Our observations together with earlier findings on genetic relatedness between human and animal PBV warrant further studies on zoonotic potential.
authors.affiliation: Division of Virology, National Institute of Cholera and Enteric Diseases (NICED), P-33, C,I,T, Road, Scheme-XM, Beliaghata, Kolkata 700 010, West Bengal, India. ganeshvirologist@yahoo.co.in.
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Ganesh
authors.forename: Krisztian
authors.initials: K
authors.lastname: Banyai
authors.forename: Gisela
authors.initials: G
authors.lastname: Masachessi
authors.forename: Zornitsa
authors.initials: Z
authors.lastname: Mladenova
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nagashima
authors.forename: Souvik
authors.initials: S
authors.lastname: Ghosh
authors.forename: Seegekote Mariyappa
authors.initials: SM
authors.lastname: Nataraju
authors.forename: Madhusudhan
authors.initials: M
authors.lastname: Pativada
authors.forename: Rahul
authors.initials: R
authors.lastname: Kumar
authors.forename: Nobumichi
authors.initials: N
authors.lastname: Kobayashi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003967:Diarrhea / Q000662:veterinary* / Q000821:virology; D004197:Disease Reservoirs / Q000821:virology; D004591:Electrophoresis, Polyacrylamide Gel / Q000662:veterinary; D005243:Feces / Q000821:virology; D005260:Female; D006734:Horse Diseases / Q000821:virology*; D006736:Horses; D006801:Humans; D007194:India; D008969:Molecular Sequence Data; D010802:Phylogeny; D018708:Picobirnavirus / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012327:RNA Virus Infections / Q000150:complications / Q000662:veterinary* / Q000821:virology; D012324:RNA-Dependent RNA Polymerase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D014764:Viral Proteins; D012324:RNA-Dependent RNA Polymerase