title: Microwave-promoted synthesis of 3-amino-substituted 1,2-benzisoxazoles.
abstract: BACKGROUND
  1,2-benzisoxazole derivatives have been the focus of numerous studies, due to their biological and chemical interest.
  
  
  RESULTS
  We demonstrate an efficient synthesis of a series of 3-amino-substituted 1,2-benzisoxazoles from a 3-chloro-1,2-benzisoxazole by microwave-promoted nucleophilic aromatic substitution. The 3-amino-1,2-benzisoxazoles prepared were obtained in 1-6 h in good-to-high yields of 54-90%. The 3-chloro-1,2-benzisoxazoles were also prepared by heating with microwave irradiation in quantitative yields in 2 h, from the corresponding 3-hydroxy-1,2-benzisoxazoles.
  
  
  CONCLUSIONS
  This efficient microwave-assisted pathway could be applied to a variety of substrates in the further development of substituted 1,2-benzisoxazoles.
authors.affiliation: Avexa Ltd. 576 Swan St, Richmond, Victoria, 3121, Australia.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Smith
authors.forename: Giang
authors.initials: G
authors.lastname: Le
authors.forename: Eric D
authors.initials: ED
authors.lastname: Jones
authors.forename: John
authors.initials: J
authors.lastname: Deadman
mesh_terms: D000588:Amines / Q000138:chemical synthesis; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008872:Microwaves; D010080:Oxazoles / Q000138:chemical synthesis*; D013997:Time Factors
chemical_list: C441200:1,2-benzisoxazole; D000588:Amines; D000927:Anticonvulsants; D014150:Antipsychotic Agents; D001583:Benzoxazoles; D007555:Isoxazoles; D010080:Oxazoles