title: [Clinical study of heparin-induced thrombocytopenia].
abstract: OBJECTIVE
  To observe the incidence of heparin-induced thrombocytopenia (HIT) in patients received unfractionated heparin (UFH) treatment, and explore the feasibility of monitoring HIT by platelet counts, as well as the significance of HIT-antibody test in HIT diagnosis.
  
  
  METHODS
  145 patients received UFH treatment in Vascular Surgery Department were studied. Before and after the UFH treatment, platelet counts, HIT-antibody ELISA test and heparin-induced platelet aggregation (HIPA) were tested.
  
  
  RESULTS
  Among the 145 patients, thrombocytopenia occurred in 40 (27.6%) cases, HIT-antibody ELISA test positive in 59 (40.7%) cases, HIPA test positive in 26 (17.9%) cases. The HIT was diagnosed in 24 (16.5%) cases, and heparin-induced thrombocytopenia and thrombosis (HITTS) occurred in 5 (3.4% in all cases, and 20.8% in HIT patients). In HIT patients, 15 patients (62.5%) were thrombocytopenia, HIT-antibody positive and HIPA test positive. Platelet counts in all of the 24 patients recovered to normal or level before UFH treatment in 3-6 days after heparin withdrawal therapy.
  
  
  CONCLUSIONS
  HIT can be early diagnosed by monitoring platelet counts, HIT-antibody ELISA test and HIPA test. Withdrawal of heparin therapy in time and use of alternative anticoagulant, HITTS rate might be expected to decline further.
authors.affiliation: Department of Hematology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.
authors.forename: Jing-hua
authors.initials: JH
authors.lastname: Wang
authors.forename: Chun-ying
authors.initials: CY
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Xie
authors.forename: De-hai
authors.initials: DH
authors.lastname: Che
authors.forename: Rui-chun
authors.initials: RC
authors.lastname: Jia
authors.forename: Wei
authors.initials: W
authors.lastname: Ju
authors.forename: Mei-juan
authors.initials: MJ
authors.lastname: Miao
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Dong-xia
authors.initials: DX
authors.lastname: Tong
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010976:Platelet Count; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D000925:Anticoagulants; D006493:Heparin