title: Dapsone-induced agranulocytosis leading to perianal abscess and death: a case report.
abstract: BACKGROUND
  Dapsone (diaminodiphenylsulfone) is used for the treatment of intractable skin diseases such as pemphigus and leprosy. The side effects of Dapsone are anemia, leukopenia, and liver dysfunction. Here, we present a case of agranulocytosis-induced septic shock, which was a side effect of Dapsone.
  
  
  METHODS
  An 82-year-old Japanese woman was transferred to our hospital with fever, leucopenia, and respiratory arrest. At the previous hospital, she had been administered Dapsone for linear IgA bullous dermatosis. At the time of admission, she presented with methemoglobinemia and septic shock, which was due to immunosuppression caused by the normal dose of Dapsone. Although her overall health initially improved, her condition deteriorated because of septic shock caused by an anal fistula. She died of sepsis on hospital day 80.
  
  
  CONCLUSIONS
  One of the side effects of Dapsone is agranulocytosis. Patients with agranulocytosis may be in danger of developing anal fistula. Therefore, care must be taken if a patient with agranulocytosis develops a decubitus ulcer in the sacral region, since it could develop into a fistula-in-ano.
authors.affiliation: Department of Emergency and Critical Care Medicine, Kimitsu Chuo Hospital, Kisarazu, Chiba, 292-8535, Japan. y-kobe@umin.org.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Kobe
authors.forename: Daisuke
authors.initials: D
authors.lastname: Setoguchi
authors.forename: Nobuya
authors.initials: N
authors.lastname: Kitamura