title: Adenocarcinoma arising in a traditional serrated adenoma of the rectosigmoid colon with osseous metaplasia.
abstract: Within the gastrointestinal tract, osseous metaplasia is an extremely rare phenomenon. It has only recently been described within a traditional serrated adenoma. Serrated colorectal carcinoma is the end point of the serrated neoplasia pathway. Left sided lesions typically arise from traditional serrated adenomas and represent only 8% of colorectal carcinomas. Herein reported is a case of colorectal adenocarcinoma arising from a traditional serrated adenoma with the rare occurrence of osseous metaplasia within the adenoma. The significance of the finding is discussed.
authors.affiliation: Histopathology Department, Douglass Hanly Moir Pathology, Macquarie Park, New South Wales, Australia. mwilsher@dhm.com.au
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Wilsher
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D000236:Adenoma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D015179:Colorectal Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D007150:Immunohistochemistry; D008679:Metaplasia / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D009999:Ossification, Heterotopic / Q000150:complications / Q000378:metabolism / Q000473:pathology*