title: In Utero Haematopoietic Stem Cell Transplantation (IUHSCT).
abstract: In utero haematopoietic stem cell transplantation (IUHSCT) is a non-myeloablative approach for the prenatal treatment of genetic disorders. However, in target disorders, where there is not a selective advantage for donor cells, a useful donor-cell chimerism has not been achieved. There are three possible barriers to engraftment following IUHSCT: limited space in the fetus due to host-cell competition; the large number of donor cells needed, and the immunological asset of recipient.
authors.affiliation: U.O.C. Ematologia II con Talassemia, Ospedali Riuniti "Villa Sofia-Cervello", Palermo.
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Renda
authors.forename: Aurelio
authors.initials: A
authors.lastname: Maggio