title: Interleukin 6-174G>C polymorphism and risk of aneurysmal subarachnoid hemorrhage: case-control study and meta-analysis.
abstract: OBJECTIVE
  Vascular inflammation contributes to the pathogenesis of aneurysmal subarachnoid hemorrhage (aSAH). Interleukin 6 (IL6) is a proinflammatory cytokine involved in many vascular pathologies. Two studies analyzing an association of the functional IL6 gene -174G>C promoter polymorphism with aSAH provided inconsistent results. The aim of this study was to investigate whether this IL6 polymorphism is associated with aSAH in a Polish population.
  
  
  METHODS
  We genotyped 276 aSAH patients and 581 unrelated control subjects. All were of Caucasian origin. In addition, a meta-analysis combining results of the current and previously published studies was conducted.
  
  
  RESULTS
  The distribution of IL6 genotypes and alleles did not differ significantly between aSAH (GG - 29.7%, GC - 50.0%, CC - 20.2%, G - 54.7%) and control subjects (GG - 32.0%, GC - 47.3%, CC - 20.7%, G - 44.3%). In the meta-analysis, the IL6-174G>C polymorphism was not associated with aSAH risk either.
  
  
  CONCLUSIONS
  We failed to find an association between the IL6 -174G>C polymorphism and aSAH in analyzed European populations.
authors.affiliation: Department of Neurology, Jagiellonian University Medical College, Krakow, Poland. pera@su.krakow.pl
authors.forename: J
authors.initials: J
authors.lastname: Pera
authors.forename: T
authors.initials: T
authors.lastname: Dziedzic
authors.forename: M
authors.initials: M
authors.lastname: Adamski
authors.forename: J
authors.initials: J
authors.lastname: Jagiella
authors.forename: M
authors.initials: M
authors.lastname: Krupa
authors.forename: M
authors.initials: M
authors.lastname: Moskala
authors.forename: A
authors.initials: A
authors.lastname: Szczudlik
authors.forename: A
authors.initials: A
authors.lastname: Slowik
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D015850:Interleukin-6