title: Separation of lanthanum, hafnium, barium and radiotracers yttrium-88 and barium-133 using crystalline zirconium phosphate and phosphonate compounds as prospective materials for a Ra-223 radioisotope generator.
abstract: Crystalline hybrid organic/inorganic ion exchangers based on zirconium phosphate and phosphonate compounds were evaluated for application in radium-223 generator for radiopharmaceutical applications. Various compositions were synthesized and the selectivity of these materials was determined for inactive lanthanum, hafnium and barium, and radiotracers yttrium-88 and barium-133. The hybrid materials show very efficient lanthanum/barium separation; the response for zirconium phosphate was even better. A small-scale column loaded with pelletized zirconium phosphate compound demonstrated excellent retention of (88)Y and release of (133)Ba.
authors.affiliation: Lynntech Inc., 7610 Eastmark Dr., College Station, TX 77840, USA.
authors.forename: Teresia
authors.initials: T
authors.lastname: Möller
authors.forename: Naima
authors.initials: N
authors.lastname: Bestaoui
authors.forename: Melissa
authors.initials: M
authors.lastname: Wierzbicki
authors.forename: Todd
authors.initials: T
authors.lastname: Adams
authors.forename: Abraham
authors.initials: A
authors.lastname: Clearfield