title: Efficacy and safety of enoxaparin during hemodialysis: results from the HENOX study.
abstract: BACKGROUND
  Low molecular weight heparins (LMWHs) have been suggested as an anticoagulant in hemodialysis (HD) since they provide convenient usage, safety and effective outcomes.
  
  
  OBJECTIVE
  Determine clinical efficacy and safety of enoxaparin sodium for the anticoagulation effect during HD in 99 clinically stable end-stage renal disease (ESRD) patients.
  
  
  METHODS
  This prospective open-label study was conducted in seven hemodialysis centers in Thailand HD prescription during the present study was similar to the previous prescriptions including the type of dialyzer. Enoxaparin sodium 0.7 mg/kg was administered into a pre-dialyzer arterial line at the beginning of the HD session. The anticoagulation effect was monitored by visual inspection of the HD line hourly and inspection of the dialyzer at the end of HD session. Vascular access compression time was monitored at both arterial and venous sites separately at the end of the HD.
  
  
  RESULTS
  HD with enoxaparin sodium resulted in no fibrin/clot formation in a hemodialysis line in 97 cases (98%), and no significant clot formation in a dialyzer in 96 cases (97%). The mean vascular compression time was 5.63 +/- 1.90 minutes at the arterial site and 5.72 +/- 2.61 minutes at the venous site. Neither major adverse events nor major hemorrhages were reported Prolonged activated partial thromboplastin times (aPTT) at 30 minutes after hemodialysis were reported in two cases. These abnormal aPTT cases returned to normal levels within 24 hours and 72 hours, respectively.
  
  
  CONCLUSIONS
  The present study suggests that a single-dose regimen of enoxaparin sodium 0.7 mg/kg is an effective, well-tolerated, and convenient alternative to sodium heparin.
authors.affiliation: Renal Division, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sikwn@mahidol.ac.th
authors.forename: Kriengsak
authors.initials: K
authors.lastname: Vareesangthip
authors.forename: Supachai
authors.initials: S
authors.lastname: Thitiarchakul
authors.forename: Inseey
authors.initials: I
authors.lastname: Kanjanakul
authors.forename: Vasant
authors.initials: V
authors.lastname: Sumethkul
authors.forename: Udom
authors.initials: U
authors.lastname: Krairittichai
authors.forename: Anutra
authors.initials: A
authors.lastname: Chittinandana
authors.forename: Derek
authors.initials: D
authors.lastname: Bannachak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects; D001780:Blood Coagulation Tests; D002408:Catheters, Indwelling; D017984:Enoxaparin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011446:Prospective Studies; D006435:Renal Dialysis; D013785:Thailand; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin