title: Cardio-ankle vascular index could reflect plaque burden in the coronary artery.
abstract: Cardio-ankle vascular index (CAVI) using the volume plethysmographic method is a noninvasive atherosclerotic indicator which is not influenced by blood pressure. Coronary intravascular ultrasound (IVUS) is a reliable technique to measure progression of atherosclerosis. The association between CAVI and IVUS has not been reported. The aim of this study was to evaluate the association between CAVI and the plaque burden measured by IVUS in the left main coronary artery (LMCA) in patients with coronary heart disease and normal LMCA. Cardio-ankle vascular index was significantly correlated with percentage plaque area (r = .649, P < .0001) measured by IVUS in the most diseased segment of LMCA. Cardio-ankle vascular index remained significant among cardiovascular disease risk factors included in the multiple regression analysis predicting percentage plaque area. Cardio-ankle vascular index was a good atherosclerotic indicator and associated with the plaque burden in nonculprit and angiographically normal LMCA.
authors.affiliation: Dokkyo Medical University, Department of Hypertension and Cardiorenal Medicine, Mibu, Tochigi, Japan. horinaka@dokkyomed.ac.jp
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horinaka
authors.forename: Akihisa
authors.initials: A
authors.lastname: Yabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yagi
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Ishimura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hara
authors.forename: Tomomi
authors.initials: T
authors.lastname: Iemura
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ishimitsu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000842:Ankle / Q000098:blood supply; D001021:Aortic Valve / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D010991:Plethysmography; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional