title: Flow visualization of a pediatric ventricular assist device during stroke volume reductions related to weaning.
abstract: The aim of this study is to define the fluid mechanics of a pulsatile pneumatically driven pediatric ventricular assist device (PVAD), for the reduced flow rates encountered during device weaning and myocardial recovery, and relate the results to the potential for thromboembolic events. We place an acrylic model of the PVAD in a mock circulatory loop filled with a viscoelastic blood analog and operate at four stroke volumes (SVs), each with two different filling conditions, to mimic how the flow rate of the device may be reduced. Particle image velocimetry is used to acquire flow field data. We find that a SV reduction method provides better rotational flow and higher wall shear rates than a beat rate reduction method; that a quick filling condition with a compressed diastolic time is better than a slow filling condition; and, that a reduction in SV to 40% led to greatly reduced fluid movement and wall shear rates that could increase the thrombogenicity of the device. SV reduction is a viable option for flow reduction during weaning, however, it does lead to significant changes to the device flow field and future studies are needed to develop operational protocols for the PVAD during bridge-to-recovery.
authors.affiliation: Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Breigh N
authors.initials: BN
authors.lastname: Roszelle
authors.forename: Steven
authors.initials: S
authors.lastname: Deutsch
authors.forename: William J
authors.initials: WJ
authors.lastname: Weiss
authors.forename: Keefe B
authors.initials: KB
authors.lastname: Manning
mesh_terms: D001783:Blood Flow Velocity; D002648:Child; D002675:Child, Preschool; D003326:Coronary Circulation; D020878:Device Removal / Q000379:methods*; D019544:Equipment Failure Analysis; D006333:Heart Failure / Q000503:physiopathology* / Q000517:prevention & control*; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D011474:Prosthesis Design; D013318:Stroke Volume; D013923:Thromboembolism / Q000209:etiology* / Q000503:physiopathology* / Q000517:prevention & control