title: Malignant peripheral nerve sheath tumor arising from the greater omentum: case report.
abstract: Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue tumors that arise from a peripheral nerve or exhibit nerve sheath differentiation. Most of these tumors arise on the trunk, extremities, or head and neck regions; they are very rarely located in the abdominal cavity. The patient was a 71-year-old man who was referred to our hospital for a mass and pain in the right lower abdomen. Abdominal computed tomography revealed a large (9 × 9 cm), well-circumscribed, lobulated, heterogeneously enhanced mass in the pelvis. Exploratory laparotomy revealed a large mass in the greater omentum, and the tumor was completely excised. Histopathological analysis revealed that the tumor was composed of spindle cells with high mitotic activity. On staining the tumor, positive results were obtained for S-100 but negative results were obtained for c-kit, cluster of differentiation (CD)34, α-smooth muscle actin, and desmin. These findings strongly supported a diagnosis of MPNST primarily arising from the greater omentum. To the best of our knowledge, this is the first reported case of an MPNST arising from the greater omentum. In this report, we have described the case of a patient with an MPNST arising from the greater omentum and have discussed the clinical characteristics and management of MPNSTs.
authors.affiliation: Deparment of Gastroenterological Surgery, Hiroshima University Hospital, Minami-ku, Hiroshima city, Hiroshima, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Miguchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takakura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Egi
authors.forename: Takao
authors.initials: T
authors.lastname: Hinoi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Adachi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Manabu
authors.initials: M
authors.lastname: Shinomura
authors.forename: Masakazu
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Masazumi
authors.initials: M
authors.lastname: Okajima
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohdan
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000737:chemistry / Q000473:pathology*; D009852:Omentum / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
chemical_list: D009418:S100 Proteins