title: Bioactivities of glycoalkaloids and their aglycones from Solanum species.
abstract: Potatoes, tomatoes, and aubergines are all species of the Solanum genus and contain a vast array of secondary metabolites including calystegine alkaloids, phenolic compounds, lectins, and glycoalkaloids. Glycoalkaloids have been the subject of many literature papers, occur widely in the human diet, and are known to induce toxicity. Therefore, from a food safety perspective further information is required regarding their analysis, toxicity, and bioavailability. This is especially important in crop cultivars derived from wild species to prevent glycoalkaloid-induced toxicity. A comprehensive review of the bioactivity of glycoalkaloids and their aglycones of the Solanum species, particularly focused on comparison of their bioactivities including their anticancer, anticholesterol, antimicrobial, anti-inflammatory, antinociceptive, and antipyretic effects, toxicity, and synergism of action of the principal Solanum glycoalkaloids, correlated to differences of their individual molecular structures is presented.
authors.affiliation: Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland.
authors.forename: Sinead Eileen
authors.initials: SE
authors.lastname: Milner
authors.forename: Nigel Patrick
authors.initials: NP
authors.lastname: Brunton
authors.forename: Peter Wyn
authors.initials: PW
authors.lastname: Jones
authors.forename: Nora Mary
authors.initials: NM
authors.lastname: O'Brien
authors.forename: Stuart Gerard
authors.initials: SG
authors.lastname: Collins
authors.forename: Anita Rose
authors.initials: AR
authors.lastname: Maguire
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology*; D018556:Crops, Agricultural / Q000737:chemistry*; D059022:Food Safety; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D032322:Solanum / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D002241:Carbohydrates