title: Conjugated Quantum Dots Inhibit the Amyloid β (1-42) Fibrillation Process.
abstract: Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid β (1-42) (Aβ (1-42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs.
authors.affiliation: 1301 Memorial Drive, Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
authors.forename: Garima
authors.initials: G
authors.lastname: Thakur
authors.forename: Miodrag
authors.initials: M
authors.lastname: Micic
authors.forename: Yuehai
authors.initials: Y
authors.lastname: Yang
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Li
authors.forename: Dania
authors.initials: D
authors.lastname: Movia
authors.forename: Silvia
authors.initials: S
authors.lastname: Giordani
authors.forename: Hongzhou
authors.initials: H
authors.lastname: Zhang
authors.forename: Roger M
authors.initials: RM
authors.lastname: Leblanc