title: Lupus anticoagulant in patients with subarachnoid haemorrhage.
abstract: BACKGROUND
  In aneurysmal subarachnoid haemorrhage (SAH), delayed cerebral ischaemia (DCI) is a serious complication that occurs in approximately 30% of patients. Lupus anticoagulant (LAC) is a risk factor for thrombotic events and has been associated with cerebral infarction after SAH.
  
  
  OBJECTIVE
  To determine the frequency of LAC in patients with SAH and its association with DCI.
  
  
  METHODS
  Patients with aneurysmal SAH from a prospectively collected database between 1998 and 2009 were included. Presence of LAC was detected with dilute Russell's viper venom time reagents. Investigation of the association with DCI was planned in case of an increased prevalence of LAC compared with the general population.
  
  
  RESULTS
  Of 511 patients, LAC was detected in only six (1.2%; 95% CI 0.4 to 2.5%). In two of these six patients, DCI was diagnosed.
  
  
  CONCLUSIONS
  No evidence was found that LAC contributes to the development of DCI in patients with aneurysmal SAH.
authors.affiliation: Department of Neurology, C03.229, University Medical Centre Utrecht, PO Box 85500, 3584 Utrecht, The Netherlands.
authors.forename: Francis A T M
authors.initials: FA
authors.lastname: van Lier
authors.forename: Rolf T
authors.initials: RT
authors.lastname: Urbanus
authors.forename: Nicolien K
authors.initials: NK
authors.lastname: de Rooij
authors.forename: Gabriel J E
authors.initials: GJ
authors.lastname: Rinkel
authors.forename: Catherina C J
authors.initials: CC
authors.lastname: Frijns
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood / Q000209:etiology; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000150:complications; D055815:Young Adult
chemical_list: D016682:Lupus Coagulation Inhibitor