title: Embryonal rhabdomyosarcoma of the uterine cervix in a 47-year-old woman.
abstract: Embryonal rhabdomyosarcoma (RMS) of the female genital tract usually occurs in the vagina during childhood. The uterine cervix as a primary site is rare, but is more frequent until the second decade of life. It usually has a good prognosis and the treatment is based on multidrug chemotherapy, radiotherapy and surgery. RMS accounts for <5% of all adult soft tissue sarcomas. Previous reports that included all primary sites showed a poorer five-year disease specific survival for adults with RMS when compared to the pediatric population. This difference has been attributed to a higher proportion of adverse prognostic clinical and pathological factors, and to inadequate treatment given to adults with RMS. A total of 115 patients with cervical embryonal RMS have previously been described; however, only 10 cases were reported in women older than 40 years. We present a 47-year-old woman treated with radical hysterectomy followed by adjuvant chemotherapy and review the current literature.
authors.affiliation: Department of Gynecological Oncology, AC Camargo Cancer Hospital, Sao Paulo, Brazil. glbaiocchi@yahoo.com.br
authors.forename: Glauco
authors.initials: G
authors.lastname: Baiocchi
authors.forename: Carlos Chaves
authors.initials: CC
authors.lastname: Faloppa
authors.forename: Cynthia Aparecida Bueno de Toledo
authors.initials: CA
authors.lastname: Osório
authors.forename: Lillian Yuri
authors.initials: LY
authors.lastname: Kumagai
authors.forename: Elza Mieko
authors.initials: EM
authors.lastname: Fukazawa
authors.forename: Isabela Werneck
authors.initials: IW
authors.lastname: Cunha
mesh_terms: D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D018233:Rhabdomyosarcoma, Embryonal / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*