title: Multiple viral coinfections among HIV/AIDS patients in China.
abstract: A cross-sectional survey was conducted to determine seroprevalence and correlates of coinfections of hepatitis B virus (HBV), hepatitis C virus (HCV), Epstein-Bar virus (EBV), herpes simplex virus including type 1 (HSV-1) and type 2 (HSV-2) among human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients in China. A total of 1,110 HIV/AIDS patients from Shanxi (Central area, n = 287), Zhejiang (Eastern area, n = 163), Yunnan (Southwestern area, n = 300) and Xinjiang (Northwestern area, n = 360) provinces were analyzed. The overall seroprevalence was 6.3% for HBsAg, 59.0% for anti-HCV IgG, 96.6% for anti-EBV IgG, 91.5% for anti-HSV-1 IgG, and 34.1% for anti-HSV-2 IgG. Eleven (1.0%) HIV/AIDS patients were coinfected with all five viruses, 177 (15.9%) with four viruses, 611 (55.0%) with three viruses, 288 (25.9%) with two viruses, 23 (2.1%) with single virus, and 1 (0.1%) with none of the five viruses. Multiple logistic regression analyses indicated that neither HBV, nor EBV and HSV-1 coinfection was associated with sociodemographic characteristics and HIV transmission mode, but HCV coinfection was associated with geographic region, age, gender, ethnicity, marital status, and HIV transmission mode, whereas HSV-2 coinfection was associated with geographic region, ethnicity and HIV transmission mode. This study suggests that HIV/AIDS patients with different regional and sociodemographic backgrounds and HIV transmission mode in China have different profiles of viral coinfections and should be subject to differential considerations in related health care programs.
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China. nhe@shmu.edu.cn
authors.forename: N
authors.initials: N
authors.lastname: He
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: H J
authors.initials: HJ
authors.lastname: Lin
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Wei
authors.forename: J H
authors.initials: JH
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Gabrio
authors.forename: B L
authors.initials: BL
authors.lastname: Rui
authors.forename: Z F
authors.initials: ZF
authors.lastname: Zhang
authors.forename: Z H
authors.initials: ZH
authors.lastname: Fu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Ding
authors.forename: G M
authors.initials: GM
authors.lastname: Zhao
authors.forename: Q W
authors.initials: QW
authors.lastname: Jiang
authors.forename: R
authors.initials: R
authors.lastname: Detels
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology*; D000367:Age Factors; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000453:epidemiology*; D005260:Female; D015528:HIV Seroprevalence / Q000639:trends*; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology*; D006558:Herpes Genitalis / Q000150:complications / Q000453:epidemiology*; D006561:Herpes Simplex / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D012737:Sex Factors; D012959:Socioeconomic Factors