title: Lactobacillus crispatus KT-11 enhances intestinal immune functions in C3H/HeN mice.
abstract: We investigated the effect of Lactobacillus crispatus KT-11 (KT-11) on intestinal immune systems in C3H/HeN mice. The level of intestinal total immunoglobulin (Ig) A was significantly higher in mice given KT-11 than in mice not given KT-11. Gene expression relating to antibody production and innate immune response increased more than 2-fold in the former compared with the later. Moreover, the number of IL-6(+)CD11b(+) cells was significantly higher in Peyer's patch cells cultured with KT-11 than in those cultured without KT-11, although the number of CD4(+) cells and the cell ratio of CD4(+)/CD8(+) were remarkably lower in the culture with KT-11. These results indicate that KT-11 enhances intestinal IgA production and innate immune response in C3H/HeN mice.
authors.affiliation: Interdisciplinary Graduate School of Science and Technology, Shinshu University, Nagano, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Tobita
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yanaka
authors.forename: Hajime
authors.initials: H
authors.lastname: Otani
mesh_terms: D000818:Animals; D000906:Antibodies / Q000378:metabolism; D039481:CD11b Antigen / Q000378:metabolism; D016516:CD4-CD8 Ratio; D015870:Gene Expression; D007109:Immunity / Q000235:genetics; D007113:Immunity, Innate; D007070:Immunoglobulin A / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology*; D007778:Lactobacillus; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology; D019936:Probiotics / Q000494:pharmacology*; D058408:Th1-Th2 Balance
chemical_list: D000906:Antibodies; D039481:CD11b Antigen; D007070:Immunoglobulin A; D015850:Interleukin-6