title: Early gallbladder carcinoma: a clinicopathologic study of 13 cases of intramucosal carcinoma.
abstract: We report the clinicopathologic features of 13 cases of intramucosal carcinoma (IMC) of the gallbladder. All IMCs were incidental findings in cholecystectomy specimens for cholelithiasis. However, one of the patients had a carcinoma of the pancreas, and the gallbladder incidentally removed during the Whipple procedure showed an IMC. Another patient had a small cell carcinoma of the gallbladder, and one of the sections showed an IMC. Of the IMCs, 10 were well-differentiated adenocarcinomas, 1 was a moderately differentiated adenocarcinoma, 1 was an undifferentiated carcinoma, and 1 was a squamous cell carcinoma. Of the patients, 8 were disease-free from 3 to 11 years, and 2 patients died, one as a result of the pancreatic ductal carcinoma and the other with disseminated metastases of the small cell carcinoma. The follow-up of another patient was too short to be significant. Two patients were lost to follow-up. Our findings suggest that a simple cholecystectomy is a curative procedure for IMCs of the gallbladder.
authors.affiliation: Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán," Mexico City, Mexico.
authors.forename: Jorge
authors.initials: J
authors.lastname: Albores-Saavedra
authors.forename: Fredy
authors.initials: F
authors.lastname: Chable-Montero
authors.forename: David
authors.initials: D
authors.lastname: Angeles-Albores
authors.forename: Arnold
authors.initials: A
authors.lastname: Schwartz
authors.forename: David S
authors.initials: DS
authors.lastname: Klimstra
authors.forename: Donald E
authors.initials: DE
authors.lastname: Henson
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D018288:Carcinoma, Small Cell / Q000556:secondary / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000473:pathology / Q000601:surgery; D005260:Female; D005706:Gallbladder Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology*; D009361:Neoplasm Invasiveness; D011230:Precancerous Conditions / Q000473:pathology* / Q000601:surgery; D011379:Prognosis