title: Role of FDG PET/CT in staging of recurrent ovarian cancer.
abstract: Ovarian cancer is the fifth leading cause of cancer death among women in the United States and has a high likelihood of recurrence despite aggressive treatment strategies. Detection and exact localization of recurrent lesions are critical for guiding management and determining the proper therapeutic approach, which may prolong survival. Because of its high sensitivity and specificity compared with those of conventional techniques such as computed tomography (CT) and magnetic resonance (MR) imaging, fluorine 18 fluorodeoxyglucose positron emission tomography (PET) combined with CT is useful for detection of recurrent or residual ovarian cancer and for monitoring response to therapy. However, PET/CT may yield false-negative results in patients with small, necrotic, mucinous, cystic, or low-grade tumors. In addition, in the posttherapy setting, inflammatory and infectious processes may lead to false-positive PET/CT results. Despite these drawbacks, PET/CT is superior to CT and MR imaging for depiction of recurrent disease.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Hongju
authors.initials: H
authors.lastname: Son
authors.forename: Shahid M
authors.initials: SM
authors.lastname: Khan
authors.forename: Jamal
authors.initials: J
authors.lastname: Rahaman
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Cameron
authors.forename: Monica
authors.initials: M
authors.lastname: Prasad-Hayes
authors.forename: Linus
authors.initials: L
authors.lastname: Chuang
authors.forename: Josef
authors.initials: J
authors.lastname: Machac
authors.forename: Sherif
authors.initials: S
authors.lastname: Heiba
authors.forename: Lale
authors.initials: L
authors.lastname: Kostakoglu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18