title: Association of interleukin-6 gene polymorphism with angina pectoris.
abstract: In this study, we investigated the role of the -174G>C polymorphism of interleukin-6 (IL-6) as a predisposing factor to angina pectoris. Patients were separated into 2 groups: angina (N = 72) and nonangina (N = 71). There were no statistical differences between groups for all cardiovascular risk factors evaluated. The GG genotype frequency was 18% lower in the angina than in the non-angina group, whereas GC + CC was 18% higher in the angina group (P = .036). The frequency of G allele was 11% lower in the angina than in the nonangina group and C allele was 11% higher in the angina group (P = .043). Patients carrying the C allele showed a 2-fold increased risk for angina pectoris (P = .036). Our study demonstrates a high incidence of the -174G>C polymorphism of the IL-6 gene in patients with angina pectoris compared with those carrying the G allele, reinforcing the contribution of genetic factors to the symptoms of angina pectoris.
authors.affiliation: Biotechnology Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Av. Marechal Campos 1468, Vitoria, Espirito Santo, Brazil.
authors.forename: Fernanda Gobbi
authors.initials: FG
authors.lastname: Amorim
authors.forename: Bianca Prandi
authors.initials: BP
authors.lastname: Campagnaro
authors.forename: Clarissa Loureiro
authors.initials: CL
authors.lastname: Tonini
authors.forename: Ana Paula Capua
authors.initials: AP
authors.lastname: Norbim
authors.forename: Iuri Drummond
authors.initials: ID
authors.lastname: Louro
authors.forename: Elisardo Corral
authors.initials: EC
authors.lastname: Vasquez
authors.forename: Jose Airton
authors.initials: JA
authors.lastname: Arruda
authors.forename: Silvana Santos
authors.initials: SS
authors.lastname: Meyrelles
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors
chemical_list: D015850:Interleukin-6