title: Immunohistochemical expression of the PRO2268 protein in psoriasis vulgaris skin.
abstract: The PRO2268 gene encodes for the PRO2268 molecule and maps to a chromosomal region (12q14), which clusters genes with a key role in immune signaling. Although the PRO2268 protein is as yet of unknown function, we should not exclude the possibility that the PRO2268 gene, because of its location, might have a distinct role in autoimmunity and inflammation. The aim of the present study was to investigate the expression pattern of the PRO2268 protein in psoriasis skin. Formalin-fixed paraffin-embedded sections from normal and psoriasis skin tissue were studied immunohistochemically using custom-ordered antibodies (anti-PRO2268#1 and anti-PRO2268#2) against the PRO2268. The present study revealed an expression of the anti-PRO2268#2 in the inflammatory infiltrate, and suggesting a possible role for the PRO2268 molecule in pathophysiology of psoriasis, which needs further investigation.
authors.affiliation: Department of Physiology, University of Tartu, Tartu, Estonia. drkmb@email.com
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Douroudis
authors.forename: Meeli
authors.initials: M
authors.lastname: Sirotkina
authors.forename: Külli
authors.initials: K
authors.lastname: Kingo
authors.forename: Rotraut
authors.initials: R
authors.lastname: Mössner
authors.forename: Sulev
authors.initials: S
authors.lastname: Kõks
mesh_terms: D015551:Autoimmunity; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D016207:Cytokines / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation; D005810:Multigene Family / Q000235:genetics*; D011506:Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011565:Psoriasis / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D012867:Skin / Q000378:metabolism* / Q000473:pathology
chemical_list: D016207:Cytokines; C561430:PRO2268 protein, human; D011506:Proteins