title: [Sorafenib in combination with chemotherapy in the induction therapy for FLT3-ITD positive acute monocytic leukemia: a case report and literature review].
abstract: OBJECTIVE
  To explore the safety and efficacy of sorafenib in combination with chemotherapy for the treatment of FLT3 positive acute myeloid leukemia (AML), to highlight the impact of FLT3 mutations and targeting therapy on response of AML.
  
  
  METHODS
  The clinical and laboratory features and the treatment response, especially the safety profile of sorafenib in an acute monocytic leukemia patient with FLT-ITD were reported.
  
  
  RESULTS
  The patient achieved clinical and molecular CR after sorafenib was added to the second course of combination chemotherapy. The side effects of sorafenib were mild and tolerable.
  
  
  CONCLUSIONS
  The patient responded well to the combination of sorafenib and standard chemotherapy of AML without significant adverse effects.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
authors.forename: Shu-ning
authors.initials: SN
authors.lastname: Wei
authors.forename: Hui
authors.initials: H
authors.lastname: Wei
authors.forename: Ying-chang
authors.initials: YC
authors.lastname: Mi
authors.forename: Bing-cheng
authors.initials: BC
authors.lastname: Liu
authors.forename: Kai-qi
authors.initials: KQ
authors.lastname: Liu
authors.forename: Chun-lin
authors.initials: CL
authors.lastname: Zhou
authors.forename: Qing-hua
authors.initials: QH
authors.lastname: Li
authors.forename: Jian-xiang
authors.initials: JX
authors.lastname: Wang
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001557:Benzenesulfonates / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy* / Q000235:genetics; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D011725:Pyridines / Q000008:administration & dosage*; D000077157:Sorafenib; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: D001557:Benzenesulfonates; D010671:Phenylurea Compounds; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3