title: Expression of glutamate receptors and potassium channels in vestibular nuclei neurons during development of signal processing.
abstract: The principal cells of the chick tangential vestibular nucleus offer a simple neuron model to study signal processing in second-order, vestibular reflex projection neurons. The principal cells represent a relatively uniform population of vestibular nuclei neurons which receive a major input from the primary vestibular fibers and send axons to targets mainly involved in the vestibuloocular reflexes. Here, studies performed on ion channels involved in the emergence and establishment of signal processing in this morphologically-identified subset of vestibular nuclei neurons are reviewed, including the AMPA glutamate receptor subunits GluR1, GluR2, GluR3, and GluR4 and the potassium channel subunits Kv1.1 and Kv1.2.
authors.affiliation: Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, Washington, DC 20037, USA.
authors.forename: Anastas
authors.initials: A
authors.lastname: Popratiloff
authors.forename: Mei
authors.initials: M
authors.lastname: Shao
authors.forename: June C
authors.initials: JC
authors.lastname: Hirsch
authors.forename: Kenna D
authors.initials: KD
authors.lastname: Peusner
mesh_terms: D000818:Animals; D002645:Chickens; D018507:Gene Expression Regulation, Developmental; D051662:Kv1.1 Potassium Channel / Q000096:biosynthesis*; D051663:Kv1.2 Potassium Channel / Q000096:biosynthesis*; D009474:Neurons / Q000378:metabolism*; D018091:Receptors, AMPA / Q000096:biosynthesis*; D015398:Signal Transduction / Q000502:physiology*; D014726:Vestibular Nuclei / Q000166:cytology / Q000254:growth & development* / Q000502:physiology; D014722:Vestibule, Labyrinth / Q000378:metabolism
chemical_list: D051662:Kv1.1 Potassium Channel; D051663:Kv1.2 Potassium Channel; D018091:Receptors, AMPA