title: Gender-specific differences in the association of adiponectin gene polymorphisms with body mass index.
abstract: OBJECTIVE
  Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes (T2D). The study evaluated possible associations of +45T/G and -11391G/A adiponectin gene polymorphisms with body mass index (BMI), waist circumferences (WC), and blood pressure in diabetic and non-diabetic Iranians.
  
  
  METHODS
  This cross-sectional study involved two groups of subjects: 243 diabetic patients and 173 non-diabetic subjects recruited from Rafsanjan city in the south-east of Iran.
  
  
  RESULTS
  No significant association was found between +45T/G and -11391G/A adiponectin gene polymorphisms and systolic or diastolic blood pressure. However, male carriers of the TT genotype of +45T/G had a significantly higher mean BMI than male GG homozygotes (p = 0.018). Also, male carriers of the GG genotype of -11391G/A had significantly higher mean BMI than male GA or AA homozygotes (p = 0.041). Female carriers of the GG genotype of -11391G/A had significantly higher mean WC than female GA or AA homozygotes (p = 0.038).
  
  
  CONCLUSIONS
  We observed a significantly higher BMI in women, and GA or AA carriers of -11391G/A polymorphism. Also, there was a significantly lower WC in females and GG carriers of +45T/G. These results point to a gender-specific impact of the studied genotypes on BMI and WC.
authors.affiliation: Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ozra
authors.initials: O
authors.lastname: Tabatabaei-Malazy
authors.forename: Shirin
authors.initials: S
authors.lastname: Hasani-Ranjbar
authors.forename: Mahsa M
authors.initials: MM
authors.lastname: Amoli
authors.forename: Ramin
authors.initials: R
authors.lastname: Heshmat
authors.forename: Mohammadali
authors.initials: M
authors.lastname: Sajadi
authors.forename: Reza
authors.initials: R
authors.lastname: Derakhshan
authors.forename: Parvin
authors.initials: P
authors.lastname: Amiri
authors.forename: Mahsa
authors.initials: M
authors.lastname: Namakchian
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Rezazadeh
authors.forename: Javad
authors.initials: J
authors.lastname: Tavakkoly-Bazzaz
authors.forename: Abbasali
authors.initials: A
authors.lastname: Keshtkar
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012727:Sex Characteristics; D055105:Waist Circumference
chemical_list: D052242:Adiponectin