title: [Effect of granulocyte colony stimulating factor EPC on cardiac function in patients with heart failure after myocardial infarction].
abstract: OBJECTIVE
  To study the changes of cardiac function following treatment with granulocyte colony stimulating factor (G-CSF) in patients with heart failure after myocardial infarction.
  
  
  METHODS
  Thirty-eight patients with heart failure after myocardial infarction were randomized into G-CSF treatment group and control group. All the patients received conventional treatment (medication and interventional therapy), and the patients in treatment group were given additional G-CSF (600 µg/day) for 7 consecutive days. The plasma level of brain-type natriuretic peptide (BNP) and the number of endothelial progenitor cells (EPCs) in the peripheral blood were detected before and at 7 days and 4 months after the treatment. The cardiac functions (LVSD, EDV, and LVEF) were evaluated by ultrasonic imaging before and at 2 weeks and 4 months after the treatment.
  
  
  RESULTS
  The number of EPCs was significantly higher in the treatment group than in the control group after the treatment especially at 7 days (P<0.01). In both groups, BNP level was lowered significantly after the treatment to recover the normal level (P<0.01). The cardiac functions were improved in all the patients at 7 days and 4 months after the treatment, and the improvement was more obvious in the treatment group (P<0.05), especially in terms of LVEF at 4 months after the treatment (P<0.01).
  
  
  CONCLUSIONS
  EPC mobilization by G-CSF can effectively improve the cardiac functions and lessen ventricular remodeling in patients with heart failure after myocardial infarction.
authors.affiliation: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. no0@163.com
authors.forename: Zi-lin
authors.initials: ZL
authors.lastname: ZHAO
authors.forename: Ding-li
authors.initials: DL
authors.lastname: XU
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: GUO
authors.forename: Ping-sheng
authors.initials: PS
authors.lastname: WU
authors.forename: An-na
authors.initials: AN
authors.lastname: Shen
mesh_terms: D000368:Aged; D042783:Endothelial Cells / Q000166:cytology; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D023461:Myeloid Progenitor Cells / Q000166:cytology; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D016896:Treatment Outcome; D020257:Ventricular Remodeling
chemical_list: D020097:Natriuretic Peptide, Brain; D016179:Granulocyte Colony-Stimulating Factor