title: Creating probabilistic maps of the face network in the adolescent brain: a multicentre functional MRI study.
abstract: Large-scale magnetic resonance (MR) studies of the human brain offer unique opportunities for identifying genetic and environmental factors shaping the human brain. Here, we describe a dataset collected in the context of a multi-centre study of the adolescent brain, namely the IMAGEN Study. We focus on one of the functional paradigms included in the project to probe the brain network underlying processing of ambiguous and angry faces. Using functional MR (fMRI) data collected in 1,110 adolescents, we constructed probabilistic maps of the neural network engaged consistently while viewing the ambiguous or angry faces; 21 brain regions responding to faces with high probability were identified. We were also able to address several methodological issues, including the minimal sample size yielding a stable location of a test region, namely the fusiform face area (FFA), as well as the effect of acquisition site (eight sites) and scanner (four manufacturers) on the location and magnitude of the fMRI response to faces in the FFA. Finally, we provided a comparison between male and female adolescents in terms of the effect sizes of sex differences in brain response to the ambiguous and angry faces in the 21 regions of interest. Overall, we found a stronger neural response to the ambiguous faces in several cortical regions, including the fusiform face area, in female (vs. male) adolescents, and a slightly stronger response to the angry faces in the amygdala of male (vs. female) adolescents.
authors.affiliation: Rotman Research Institute, University of Toronto, Toronto, Canada.
authors.forename: Amir M
authors.initials: AM
authors.lastname: Tahmasebi
authors.forename: Eric
authors.initials: E
authors.lastname: Artiges
authors.forename: Tobias
authors.initials: T
authors.lastname: Banaschewski
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Barker
authors.forename: Ruediger
authors.initials: R
authors.lastname: Bruehl
authors.forename: Christian
authors.initials: C
authors.lastname: Büchel
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Conrod
authors.forename: Herta
authors.initials: H
authors.lastname: Flor
authors.forename: Hugh
authors.initials: H
authors.lastname: Garavan
authors.forename: Jürgen
authors.initials: J
authors.lastname: Gallinat
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
authors.forename: Bernd
authors.initials: B
authors.lastname: Ittermann
authors.forename: Eva
authors.initials: E
authors.lastname: Loth
authors.forename: Klara
authors.initials: K
authors.lastname: Mareckova
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Martinot
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Poline
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Michael N
authors.initials: MN
authors.lastname: Smolka
authors.forename: Andreas
authors.initials: A
authors.lastname: Ströhle
authors.forename: Gunter
authors.initials: G
authors.lastname: Schumann
authors.forename: Tomáš
authors.initials: T
authors.lastname: Paus
mesh_terms: D000293:Adolescent; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D004644:Emotions / Q000502:physiology*; D005145:Face; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D012727:Sex Characteristics; D014796:Visual Perception / Q000502:physiology*