title: The coordination of T-cell function by serine/threonine kinases.
abstract: The function of T-lymphocytes during adaptive immune responses is directed by antigen receptors, costimulatory molecules, and cytokines. These extrinsic stimuli are coupled to a network of serine/threonine kinases that control the epigenetic, transcriptional, and metabolic programs that determine T-cell function. It is increasingly recognized that serine/threonine kinases, notably those that are controlled by lipid second messengers such as polyunsaturated diacylglycerols (DAG) and phosphatidylinositol-(3,4,5)-trisphosphate (PIP(3)), are at the core of T-cell signal transduction. In the present review the object will be to discuss some important examples of how pathways of serine/threonine phosphorylation control molecular functions of proteins and control protein localization to coordinate T-cell function in adaptive immune responses.
authors.affiliation: Division of Cell Biology and Immunology, University of Dundee, Dundee, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Finlay
authors.forename: Doreen
authors.initials: D
authors.lastname: Cantrell
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000276:immunology / Q000378:metabolism*; D015290:Second Messenger Systems / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D017346:Protein Serine-Threonine Kinases