title: Yessotoxin as an apoptotic inducer.
abstract: This work summarises current knowledge on how the marine toxin yessotoxin (YTX) induces apoptosis in different types of cells. The work also addresses perspectives for future research on this topic. YTX triggers apoptosis in a variety of cellular systems including cancer cells. The actual apoptotic pathways are not fully understood and seem to be cell-specific. YTX can induce the mitochondrial pathway in myoblast cell lines, but its potential to activate other signalling pathways and possible cross-talk between them has not been reported. Improvement in our understanding of death signalling induction by YTX may contribute to identifying novel molecular mechanisms of interest for therapeutic applications.
authors.affiliation: The Norwegian School of Veterinary Science, P.O. Box 8146 Dep., N-0033 Oslo, Norway. monica.suarez.korsnes@nvh.no
authors.forename: Mónica Suárez
authors.initials: MS
authors.lastname: Korsnes
authors.forename: Arild
authors.initials: A
authors.lastname: Espenes
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D008928:Mitochondria / Q000187:drug effects; D008978:Mollusk Venoms; D032446:Myoblasts / Q000187:drug effects; D035964:Oxocins / Q000737:chemistry / Q000633:toxicity*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D008978:Mollusk Venoms; D035964:Oxocins; C066632:yessotoxin