title: Serial high-resolution computed tomography findings of acute and chronic hypersensitivity pneumonitis induced by avian antigen.
abstract: OBJECTIVE
  The purpose of this study was to evaluate serial changes and the prognostic value of high-resolution computed tomographic (HRCT) findings in hypersensitivity pneumonitis (HP).
  
  
  METHODS
  The medical records of 112 patients with bird-related HP (17 acute, 33 recurrent, and 62 insidious) were retrospectively reviewed. High-resolution computed tomographic findings at the time of diagnosis and at follow-up were retrospectively interpreted.
  
  
  RESULTS
  Ground-glass opacities and centrilobular nodules were predominant findings in acute and recurrent HP, whereas honeycombing was the outstanding feature in insidious HP. Areas of ground-glass opacities and centrilobular nodules decreased in all groups over a long-term follow-up. Areas of honeycombing, on the other hand, increased in chronic HP, especially in the insidious cases. Cox regression models revealed a higher mortality risk in cases with airspace consolidation and honeycombing on HRCT.
  
  
  CONCLUSIONS
  Acute, recurrent, and insidious HP all have characteristic features on CT. Characteristic HRCT findings can predict the prognosis of chronic HP.
authors.affiliation: Department of Integrated Pulmonology, Tokyo, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Tateishi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ohtani
authors.forename: Tamiko
authors.initials: T
authors.lastname: Takemura
authors.forename: Takumi
authors.initials: T
authors.lastname: Akashi
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Naohiko
authors.initials: N
authors.lastname: Inase
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yoshizawa
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001716:Bird Fancier's Lung; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*