title: [Expression and clinical significance of Trop-2 in human pancreatic cancer].
abstract: OBJECTIVE
  To investigate the expression and its clinical significance of Trop-2 in human pancreatic cancer.
  
  
  METHODS
  Reverse transcription-polymerase chain reaction (RT-PCR) and immunofluorescence assay were used to characterize the expression of Trop-2 in human pancreatic cancer. The expression of Trop-2 protein in 31 tumor tissue samples, including peritumoral tissue from patients with pancreatic cancer, was detected with immunohistochemistry by tissue microarray. The clinicopathological characteristics and the tissue expression of Trop-2 protein were analyzed statistically.
  
  
  RESULTS
  RT-PCR, immunofluorescence assay and immunohistochemistry by tissue microarray showed a high expression of Trop-2 in pancreatic cancer. The expression rate of Trop-2 was much higher in pancreatic cancer than that in peritumoral tissues (87.1% vs 9.7%). And a high expression of Trop-2 in pancreatic cancer was correlated with the low-differentiated changes. It had statistical significance (P < 0.05). In contrast, no statistically significant correlation was found between the expression of Trop-2 and gender or age.
  
  
  CONCLUSIONS
  The expression of Trop-2 is correlated with the development and malignancy of pancreatic cancer. As a clinical prognostic marker, Trop-2 may be a potential therapeutic target for pancreatic cancer.
authors.affiliation: First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Jin-Rong
authors.initials: JR
authors.lastname: Qiu
authors.forename: Qi
authors.initials: Q
authors.lastname: Tang
authors.forename: Hong
authors.initials: H
authors.lastname: Lin
authors.forename: Zhong-Can
authors.initials: ZC
authors.lastname: Wang
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000235:genetics / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D012333:RNA, Messenger; C499380:TACSTD2 protein, human