title: Insulin receptor activation in deletion 11q chronic lymphocytic leukemia.
abstract: The chromosomal abnormalities characteristic of chronic lymphocytic leukemia (CLL) are well studied, but the mechanisms underlying their contribution to pathogenesis are only partially elucidated. Integrated genomic profiling, focused on deletion 11q, has identified elevated expression of the insulin receptor in a subgroup of CLLs and associated it with worse outcomes.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Brown
mesh_terms: D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D011379:Prognosis; D011972:Receptor, Insulin / Q000378:metabolism*
chemical_list: D011972:Receptor, Insulin