title: [Chronic use of proton pump inhibitors: is the risk of osteoporosis and fractures real?].
abstract: Proton pump inhibitors (PPI) are one of the most widely used groups of drugs and their potential toxicity is periodically reviewed, emphasizing aspects originally considered secondary. The present review analyzes the physiological and pharmacological bases and the scarce clinical evidence for a potential association between the continued administration of PPI and the development of osteoporosis and bone fractures. Both disorders are clearly related to calcium homeostasis and are highly important in elderly patients due to their poor general prognosis and disabling consequences.
authors.affiliation: Departamento de Farmacología, Facultad de Medicina y Odontología, Universidad de Valencia, España.
authors.forename: Miguel
authors.initials: M
authors.lastname: Martí-Cabrera
authors.forename: Miguel
authors.initials: M
authors.lastname: Martí-Masanet
authors.forename: Juan V
authors.initials: JV
authors.lastname: Esplugues
mesh_terms: D000126:Achlorhydria / Q000139:chemically induced / Q000503:physiopathology; D000375:Aging / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002136:Calcium, Dietary / Q000493:pharmacokinetics; D015897:Comorbidity; D004198:Disease Susceptibility; D005598:Fractures, Spontaneous / Q000139:chemically induced* / Q000209:etiology; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000139:chemically induced; D007408:Intestinal Absorption / Q000187:drug effects; D008286:Malabsorption Syndromes / Q000139:chemically induced / Q000503:physiopathology; D008954:Models, Biological; D010024:Osteoporosis / Q000139:chemically induced* / Q000209:etiology / Q000503:physiopathology; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D012306:Risk
chemical_list: D002136:Calcium, Dietary; D005755:Gastrins; D054328:Proton Pump Inhibitors; D002118:Calcium