title: In vivo detection of chemiluminescence to monitor photodynamic threshold dose for tumor treatment.
abstract: During photodynamic therapy (PDT) it is important to monitor the treatment progress to achieve the intended therapeutic outcome. Chemiluminescence (CL) provides a sensitive and selective means for (1)O(2) detection. In our study, by comparing CL with the corresponding in situ PDT treatment protocols and the treatment effect, the results indicate that the treatment outcome for tumors was governed by a set of dosimetry factors with a rather complicated relationship, but there was a remarkable connection between tumor treatment effect and CL. In conclusion, CL can be used in in vivo PDT to determine the dose of tumor treatment and monitor the treatment threshold. By monitoring CL it is feasible to determine PDT dose to predict tumor treatment effect.
authors.affiliation: MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Wei
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Song
authors.forename: Qun
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D017323:Dihematoporphyrin Ether / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D005452:Fluoresceins / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry; D008027:Light; D008163:Luminescent Measurements; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use; D026082:Singlet Oxygen / Q000378:metabolism
chemical_list: D005452:Fluoresceins; D007093:Imidazoles; D017319:Photosensitizing Agents; C080213:3,7-dihydro-6-(4-(2-(N'-(5-fluoresceinyl)thioureido)ethoxy)phenyl)-2-methylimidazo-(1,2-a)pyrazin-3-one; D026082:Singlet Oxygen; D017323:Dihematoporphyrin Ether