title: Autophagy: regulation by energy sensing.
abstract: Autophagy is inhibited by the mTOR signaling pathway, which is stimulated by increased amino acid levels. When cellular energy production is compromised, AMP-activated protein kinase is activated, mTOR is inhibited and autophagy is stimulated. Two recent studies have shed light on the molecular mechanism by which AMPK controls autophagic flux.
authors.affiliation: Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands. a.j.meijer@amc.uva.nl
authors.forename: Alfred J
authors.initials: AJ
authors.lastname: Meijer
authors.forename: Patrice
authors.initials: P
authors.lastname: Codogno
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D001343:Autophagy / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D058570:TOR Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases