title: [The course of the diabetes type I in pregnants with different levels of antibodies to insulin].
abstract: The course of the diabetes type I at pregnants (n=120) with different levels of idiotypic (ABI) and antiidiotypic (AB2) antibodies to insulin was investigated. It is known that AB2 to insulin can interact with insulin receptor. It was shown that changes of levels AB1 and AB2 to insulin are often observed at pregnants suffered from diabetes type I. Isolated high levels of AB1 to insulin is relatively good prognostic sign of the course of the diabetes type I at pregnants. On the contrary, isolated high levels of AB2 to insulin lead to decompensation of the diabetes type I and deep glycohemia. High levels of AB1 and AB2 to insulin together lead to unstable course of the diabetes type I. The same situation is observed in case of abnormal low levels AB1 and AB2 to insulin, taking into consideration that serum of health people contains the certain level of autoantibodies (AB1 and AB2) to insulin. The conclusion about significance of detection AB1 and AB2 to insulin during pregnancy of patients with diabetes type I was made.
authors.forename: A M
authors.initials: AM
authors.lastname: Protsenko
authors.forename: T S
authors.initials: TS
authors.lastname: Budykina
authors.forename: S G
authors.initials: SG
authors.lastname: Morozov
authors.forename: O M
authors.initials: OM
authors.lastname: Anikina
authors.forename: F F
authors.initials: FF
authors.lastname: Burumkulova
authors.forename: V A
authors.initials: VA
authors.lastname: Petrukhin
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000097:blood* / Q000276:immunology; D007328:Insulin; D008297:Male; D011247:Pregnancy / Q000097:blood; D011254:Pregnancy in Diabetics / Q000097:blood* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes; D007328:Insulin