title: [Differential pharmacokinetic characteristics of micafungin. Experience in special populations].
abstract: Currently, three echinocandins are available for the treatment of fungal infections. Micafungin is the latest drug to be incorporated into this group of antifungal agents. Although the mechanism of action of micafungin is similar to that of other echinocandins, this molecule has certain pharmacokinetic characteristics that distinguish it from other drugs in this group. Nowadays, there is wide information on the pharmacokinetic behavior of micafungin, mainly from patients included in clinical trials. However, there is far less knowledge of the pharmacokinetics of this echinocandin in special populations. The aim of the current review was to analyze the available information on the pharmacokinetics of micafungin in pediatric patients, the elderly, patients with renal insufficiency or liver failure, and transplant recipient.
authors.affiliation: Servicio de Farmacia, Hospital del Mar, Barcelona, España. sgrau@hospitaldelmar.cat
authors.forename: Santiago
authors.initials: S
authors.lastname: Grau Cerrato
authors.forename: Sonia
authors.initials: S
authors.lastname: Luque Pardos
authors.forename: Olivia
authors.initials: O
authors.lastname: Ferrández Quirante
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D015897:Comorbidity; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism; D004347:Drug Interactions; D054714:Echinocandins / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000150:complications / Q000378:metabolism; D055666:Lipopeptides / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008107:Liver Diseases / Q000150:complications / Q000378:metabolism; D000077551:Micafungin; D008875:Middle Aged; D009181:Mycoses / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D011183:Postoperative Complications / Q000188:drug therapy; D014180:Transplantation; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D000077551:Micafungin