title: Chest pain in asbestos and silica-exposed workers.
abstract: BACKGROUND
  Chest pain may be the first symptom of developing respiratory malignancy, particularly in subjects with asbestos exposure, yet little information exists on this topic.
  
  
  OBJECTIVE
  To investigate chest pain in a cohort of subjects exposed to asbestos and silica dust applying for compensation.
  
  
  METHODS
  Cross-sectional study using a standardized questionnaire. Data collection included: smoking history, Medical Research Council scales of exercise capacity and respiratory symptoms.
  
  
  RESULTS
  We studied 621 subjects. Six disease groups were categorized: asbestosis (n = 27), diffuse pleural thickening (DPT) (132), asbestosis and DPT (14), silicosis (26), pleural plaques only (160) and healthy subjects with a history of dust exposure (256). Crude prevalence rates of chest pain were high, with chest pain approximately twice as common in subjects with asbestos-related disorders and silicosis as in healthy subjects, with an overall frequency of ~40%. However, when other variables were taken into account in a multivariate analysis the differences between groups disappeared. The factor most significantly related to chest pain was age.
  
  
  CONCLUSIONS
  Chest pain is apparently common in subjects with asbestos-related disorders and silicosis, but after adjustment for other variables, no increased prevalence was apparent in subjects with pleural disorders. More sophisticated questionnaires and dedicated imaging are required to elucidate this further.
authors.affiliation: Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, 807-8555, Japan.
authors.forename: E-K
authors.initials: EK
authors.lastname: Park
authors.forename: P S
authors.initials: PS
authors.lastname: Thomas
authors.forename: D
authors.initials: D
authors.lastname: Wilson
authors.forename: H J
authors.initials: HJ
authors.lastname: Choi
authors.forename: A R
authors.initials: AR
authors.lastname: Johnson
authors.forename: D H
authors.initials: DH
authors.lastname: Yates
mesh_terms: D000368:Aged; D001194:Asbestos / Q000633:toxicity*; D001315:Australia / Q000453:epidemiology; D002637:Chest Pain / Q000453:epidemiology* / Q000209:etiology; D004391:Dust; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*; D010995:Pleural Diseases / Q000150:complications; D012822:Silicon Dioxide / Q000633:toxicity*; D011795:Surveys and Questionnaires
chemical_list: D004391:Dust; D001194:Asbestos; D012822:Silicon Dioxide