title: Hematological consequences of pandemic influenza H1N1 infection: a single center experience.
abstract: Since its identification in April 2009, pandemic influenza H1N1 virus has affected thousands of people worldwide. Viruses, particularly Epstein-Barr virus, cytomegalovirus and parvovirus B19, may have diverse hematological consequences, including anemia, neutropenia, thrombocytopenia, lymphocytosis, hemophagocytic lymphohistiocytosis, and coagulation abnormalities. In this study, a total of 31 consecutive pediatric patients, with and without chronic diseases, who had flu symptoms and were confirmed to have pandemic influenza, were evaluated for hematological consequences upon presentation to hospital. Eight (25.8%) patients had leukopenia and six (19.4%) had thrombocytopenia at the time of diagnosis of H1N1 infection. Pandemic influenza H1N1 infection may cause diverse hematological findings, including cytopenias and hemophagocytosis.
authors.affiliation: Unit of Pediatric Hematology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Unal
authors.forename: Müge
authors.initials: M
authors.lastname: Gökçe
authors.forename: Selin
authors.initials: S
authors.lastname: Aytaç-Elmas
authors.forename: Erdem
authors.initials: E
authors.lastname: Karabulut
authors.forename: Ilhan
authors.initials: I
authors.lastname: Altan
authors.forename: Aslinur
authors.initials: A
authors.lastname: Ozkaya-Parlakay
authors.forename: Ateş
authors.initials: A
authors.lastname: Kara
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ceyhan
authors.forename: Ali Bülent
authors.initials: AB
authors.lastname: Cengiz
authors.forename: Murat
authors.initials: M
authors.lastname: Tuncer
authors.forename: Mualla
authors.initials: M
authors.lastname: Cetin
authors.forename: Fatma
authors.initials: F
authors.lastname: Gümrük
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006402:Hematologic Diseases / Q000209:etiology*; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D007970:Leukopenia / Q000209:etiology; D008297:Male; D058873:Pandemics; D013921:Thrombocytopenia / Q000209:etiology