title: Synthesis and in vitro insulin-mimetic activities of zinc(ii) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates.
abstract: Several Zn(II) complexes (2a-e) of 1-arylmethyl-2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates (1a-e), known drug candidates for diabetic complications, were synthesized and proved to have in vitro insulin-mimetic activities, suggesting that these complexes are potential chemotherapeutics that are effective against both diabetes and diabetic complications.
authors.affiliation: Department of Chemistry, Toho University, 2-2-1 Miyama, Funabashi, Chiba, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kawarada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yasui
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kuwahara
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Habata
authors.forename: Ryota
authors.initials: R
authors.lastname: Saito
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D018360:Crystallography, X-Ray; D004837:Epinephrine / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D020128:Inhibitory Concentration 50; D007328:Insulin / Q000031:analogs & derivatives*; D008968:Molecular Conformation; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D005227:Fatty Acids; D007328:Insulin; D011758:Pyrroles; D015032:Zinc; D004837:Epinephrine