title: Use of multicomponent reactions in developing small-molecule tools to study GABAA receptor mechanism and function.
abstract: We discuss the potential use of multicomponent reactions in developing small-molecule probes of GABA(A) receptor function. Two examples that illustrate this approach are presented: the synthesis of a class of compounds that specifically modulate the function of GABA(A) receptors containing the δ-subunit, and also 'caged' GABA derivatives. A caged GABA is a photolabile precursor of GABA that releases GABA upon photolysis.
authors.affiliation: Department of Molecular Biology & Genetics, Cornell University, Ithaca, NY 14853-2703, USA.
authors.forename: Ryan W
authors.initials: RW
authors.lastname: Lewis
authors.forename: George P
authors.initials: GP
authors.lastname: Hess
authors.forename: Bruce
authors.initials: B
authors.lastname: Ganem
mesh_terms: D057809:HEK293 Cells; D006801:Humans; D015394:Molecular Structure; D010777:Photochemistry / Q000379:methods; D010782:Photolysis; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry; D011963:Receptors, GABA-A / Q000737:chemistry / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D011744:Pyrimidinones; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid