title: [Thrombotic risk in assisted reproductive technology].
abstract: Use of assisted reproductive technology (ART) is increasing in many developed countries. Arterial and venous thromboembolic complications are reported during ART with an incidence of 0.1%. The development of these events has been mainly ascribed to the presence of ovarian hyperstimulation syndrome (OHSS). Precise mechanisms by which OHSS and exogenous hormonal stimulation used in ART induce thromboembolic events remain unclear. However, vascular endothelial growth factor secreted during OHSS, high estradiol concentrations, and blood hyperviscosity play a major role in inducing a prothrombotic state. Therefore, before planning an ART, individual thromboembolic risk should be assessed and thromboprophylaxis offered to high risk patients. Prophylaxis should be initiated in women who develop moderate-to-severe OHSS.
authors.affiliation: Service d'angiologie, CHUV, 1011 Lausanne. adriano.alatri@chuv.ch
authors.forename: Adriano
authors.initials: A
authors.lastname: Alatri
authors.forename: Bruno
authors.initials: B
authors.lastname: Tribout
authors.forename: Baris
authors.initials: B
authors.lastname: Gencer
authors.forename: Luca
authors.initials: L
authors.lastname: Calanca
authors.forename: Lucia
authors.initials: L
authors.lastname: Mazzolai
mesh_terms: D015415:Biomarkers / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D015994:Incidence; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A; D004958:Estradiol