title: [Concentration of 8-isoprostaglandin F2alpha depending on type of anesthesia in laparoscopic surgery in gynecology].
abstract: The article represents a randomized comparative study including 100 patients from 21 to 34 years old who has underwent a laparoscopic surgery in V. I. Kulakov Research Center of Obstetrics, Gynaecology, and Perinatology in 2007-2009. Patients were anaesthetized either with a spinal anaesthesia at L3-L4 level with bupivacaine or with a multi-component general anaesthesia using fentanyl, midazolam, propofol, rocuronium and artificial lung ventilation. Assessment of the serum 8-isoprostaglandin F2alpha before the surgery and 2 hours after the end of surgery has shown the increase of this oxidative stress marker in the early post-surgery period. However, in spinal anaesthesia group, the increase was significantly lower, indicating a more physiological nature of this method of anaesthesia.
authors.forename: S V
authors.initials: SV
authors.lastname: Petrov
authors.forename: T A
authors.initials: TA
authors.lastname: Nazarenko
authors.forename: L A
authors.initials: LA
authors.lastname: Podrez
authors.forename: A V
authors.initials: AV
authors.lastname: Pyregov
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects / Q000379:methods*; D000773:Anesthesia, Obstetrical / Q000009:adverse effects / Q000379:methods*; D000775:Anesthesia, Spinal / Q000009:adverse effects / Q000379:methods*; D015415:Biomarkers / Q000097:blood; D003627:Data Interpretation, Statistical; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000601:surgery*; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods*; D018384:Oxidative Stress; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost