title: Nitric oxide-donating materials and their potential in pharmacological applications for site-specific nitric oxide delivery.
abstract: The discovery of various regulatory, protective and deleterious effects of nitric oxide (NO) has prompted intense research activity in the design and synthesis of NO-donating drugs and materials that can be used to modulate the effective concentrations of NO at biological targets. To date, various NO-donating compounds have been incorporated or immobilized in biocompatible polymer matrices and such materials have been used as patches, wound dressings, coatings on blood-contacting medical devices and time-release NO drugs. Recently, attention has been drawn toward light-sensitive NO donors, such as S-nitrosothiols and metal nitrosyls, which can deliver NO at selected targets under the total control of light. The pharmacological potential of such NO-donating materials including those with immobilized photoactive NO donors are reviewed in this article.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, 95064, USA.
authors.forename: Aura A
authors.initials: AA
authors.lastname: Eroy-Reveles
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Mascharak
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D016503:Drug Delivery Systems; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D009569:Nitric Oxide / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D020030:Nitric Oxide Donors / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D010777:Photochemistry; D026403:S-Nitrosothiols / Q000737:chemistry; D012871:Skin Diseases / Q000188:drug therapy; D014945:Wound Healing / Q000187:drug effects
chemical_list: D020030:Nitric Oxide Donors; D026403:S-Nitrosothiols; D009569:Nitric Oxide