title: Are bicuspid aortic valves a limitation for aortic valve repair?
abstract: OBJECTIVE
  To compare the mid-term results after aortic valve (AV) repair in bicuspid AVs with those in tricuspid AVs.
  
  
  METHODS
  Between 2000 and 2010, 100 patients (mean age 47.2 years) underwent AV repair procedures for insufficient bicuspid AV (n=43) and tricuspid AV (n=57). Aortic regurgitation (AR) more than moderate was present in 31/43 and 21/57 patients in the bicuspid AV and the tricuspid AV group, respectively. Concomitant root replacement by either the reimplantation or the remodeling technique was performed in 42 patients (bicuspid AV 17/43, tricuspid AV 25/57). All patients were prospectively studied with postoperative and further annual clinical assessment and echocardiography. Follow-up was 99% complete with a mean follow-up time of 22 months.
  
  
  RESULTS
  Three patients died during the initial hospitalization, all due to postoperative cardiac failure. Overall actuarial 3 years' survival was 93±4.2% without significant differences between the two groups. Overall actuarial 3 years' freedom from AV-related reoperation was 86±5.1% without significant differences between the groups (85±9.7% for bicuspid AV, 86±6.0% for tricuspid AV; log-rank test: p=0.98). Overall actuarial 3 years' freedom from recurrent AR≥moderate was 100% and AR>trace was 71.3±8.2% without significant differences between the groups (76.5±11.7% for bicuspid AV, 71.4±9.4 for tricuspid AV; log-rank test: p=0.97).
  
  
  CONCLUSIONS
  The mid-term outcome in terms of survival, freedom from reoperation or recurrent AR is similar for both groups of patients after AV repair procedures. Therefore, we advocate valve repair also in patients presenting with an insufficient bicuspid AV.
authors.affiliation: German Heart Centre Munich, Department of Cardiovascular Surgery, Clinic at the Technical University Munich, Lazarettstr. 36, 80636 Munich, Germany. badiu@dhm.mhn.de
authors.forename: Catalin C
authors.initials: CC
authors.lastname: Badiu
authors.forename: Sabine
authors.initials: S
authors.lastname: Bleiziffer
authors.forename: Walter B
authors.initials: WB
authors.lastname: Eichinger
authors.forename: Iva
authors.initials: I
authors.lastname: Zaimova
authors.forename: Andrea
authors.initials: A
authors.lastname: Hutter
authors.forename: Domenico
authors.initials: D
authors.lastname: Mazzitelli
authors.forename: Bernhard
authors.initials: B
authors.lastname: Voss
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Lange
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000601:surgery; D001021:Aortic Valve / Q000002:abnormalities* / Q000503:physiopathology / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000503:physiopathology / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation; D002648:Child; D002675:Child, Preschool; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012008:Recurrence; D012086:Reoperation / Q000379:methods; D013923:Thromboembolism / Q000209:etiology; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000502:physiology; D055815:Young Adult