title: Feasibility and yield of a new EUS histology needle: results from a multicenter, pooled, cohort study.
abstract: BACKGROUND
  EUS-guided FNA is an efficacious technique for sampling intraintestinal and extraintestinal mass lesions. However, cytology has limitations to its final yield and accuracy, which may be overcome if histological specimens are provided to the pathologist.
  
  
  OBJECTIVE
  To evaluate feasibility, yield, and diagnostic accuracy of a newly developed 19-gauge, fine-needle biopsy (FNB) device.
  
  
  METHODS
  Multicenter, pooled, cohort study.
  
  
  METHODS
  Five medical centers.
  
  
  METHODS
  This study involved 109 consecutive patients with 114 intraintestinal or extraintestinal mass lesions and/or peri-intestinal lymph nodes.
  
  
  METHODS
  EUS-guided FNB (EUS-FNB) with a newly developed, 19-gauge, FNB device.
  
  
  METHODS
  Percentage of cases in which pathologists classified the sample quality as optimal for histological evaluation and the overall diagnostic accuracy compared with a composite criterion-standard diagnosis.
  
  
  RESULTS
  We evaluated 114 lesions (mean [± standard deviation] size 35.1 ± 18.7 mm; 84 malignant [73.7%] and 30 [26.3%] benign). EUS-FNB was technically feasible in 112 lesions (98.24%). Sample quality was adequate for full histological assessment in 102 lesions (89.47%). In 98 cases (85.96%), diagnosis proved to be correct according to criterion-standard diagnosis. Sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy for diagnosis of malignancy were 90.2%, 100%, 100%, 78.9%, and 92.9%, respectively.
  
  
  CONCLUSIONS
  Use of a surrogate criterion-standard diagnosis, including clinical follow-up when no surgical specimens were available, mainly in benign diagnoses.
  
  
  CONCLUSIONS
  Performing an EUS-FNB with a new 19-gauge histology needle is feasible for histopathology diagnosis of intraintestinal and extraintestinal mass lesions, offering the possibility of obtaining a core sample for histological evaluation in the majority of cases, with an overall diagnostic accuracy of over 85%.
authors.affiliation: Gastroenterology Department, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain. julio.iglesias.garcia@sergas.es
authors.forename: Julio
authors.initials: J
authors.lastname: Iglesias-Garcia
authors.forename: Jan-Werner
authors.initials: JW
authors.lastname: Poley
authors.forename: Alberto
authors.initials: A
authors.lastname: Larghi
authors.forename: Marc
authors.initials: M
authors.lastname: Giovannini
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Petrone
authors.forename: Ihab
authors.initials: I
authors.lastname: Abdulkader
authors.forename: Genevieve
authors.initials: G
authors.lastname: Monges
authors.forename: Guido
authors.initials: G
authors.lastname: Costamagna
authors.forename: Paolo
authors.initials: P
authors.lastname: Arcidiacono
authors.forename: Katharina
authors.initials: K
authors.lastname: Biermann
authors.forename: Guido
authors.initials: G
authors.lastname: Rindi
authors.forename: Erwan
authors.initials: E
authors.lastname: Bories
authors.forename: Claudio
authors.initials: C
authors.lastname: Dogloni
authors.forename: Marco
authors.initials: M
authors.lastname: Bruno
authors.forename: J Enrique
authors.initials: JE
authors.lastname: Dominguez-Muñoz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000295:instrumentation*; D015331:Cohort Studies; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009339:Needles; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional; D055815:Young Adult