title: New anticoagulants: perioperative considerations.
abstract: During preoperative patient evaluation, anaesthesiologists assess the patient's bleeding history and risks for thrombosis and initiate individualized coagulation management. New potent anticoagulants may increase blood loss and the risk for spinal haematoma in patients scheduled for neuraxial anaesthesia. Postoperative start of thromboprophylaxis and recommendations on the timing of invasive interventions help in controlling these risks. Before widespread use for cardiological indications open questions need to be answered e.g. oral drug administration in postoperative vomiting and potential interactions with postoperative pain therapy.
authors.affiliation: Department of Anaesthesia and Intensive Care, Evangelisches Krankenhaus Vienna, Vienna, Austria. sibylle.kozek@aon.at
authors.forename: Sibylle A
authors.initials: SA
authors.lastname: Kozek-Langenecker
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use; D000775:Anesthesia, Spinal; D000925:Anticoagulants / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001682:Biological Availability; D016063:Blood Loss, Surgical / Q000503:physiopathology / Q000517:prevention & control*; D003299:Cooperative Behavior; D004334:Drug Administration Schedule; D017277:Drug Approval; D004347:Drug Interactions; D004750:Enteral Nutrition; D065427:Factor Xa Inhibitors; D046748:Hematoma, Epidural, Spinal / Q000097:blood / Q000139:chemically induced*; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D033183:Interdisciplinary Communication; D019990:Perioperative Care; D011182:Postoperative Care; D011183:Postoperative Complications / Q000097:blood / Q000517:prevention & control*; D019106:Postoperative Hemorrhage / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood / Q000517:prevention & control*
chemical_list: D000700:Analgesics; D000925:Anticoagulants; D065427:Factor Xa Inhibitors