title: Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency.
abstract: BACKGROUND
  Conflicting data exist on the effects of GH replacement therapy (GHRT) on thyroid function and thyroid volume (TV) in GH-deficient (GHD) patients.
  
  
  OBJECTIVE
  The aim of this study was to assess the effects of GHRT on thyroid function and TV in adults with congenital lifetime isolated GHD (IGHD).
  
  
  METHODS
  We studied 20 GH-naïve adults with IGHD due to a homozygous mutation of the GHRH-receptor gene at baseline, after 6-month depot- GH replacement therapy (pGH), and 6-month washout (6mo). Total T(3), free T(4) (FT(4)), reverse T(3) (rT(3)), TSH, IGF-I, SHBG, and TV were measured; body surface area-corrected TV (CTV) was calculated.
  
  
  RESULTS
  IGF-I and T(3) increased pGH. T(3) levels remained elevated at 6mo. GHRT did not significantly change FT(4), rT(3), TSH, and SHBG. TV and CTV increased pGH and remained elevated at 6mo.
  
  
  CONCLUSIONS
  GHRT in IGHD adults caused an increase in serum T(3) levels and TV, suggesting an important role of the GH-IGF-I axis in thyroid function.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, Federal University of Sergipe, Aracaju, Brazil.
authors.forename: N T F
authors.initials: NT
authors.lastname: Leite
authors.forename: R
authors.initials: R
authors.lastname: Salvatori
authors.forename: M R S
authors.initials: MR
authors.lastname: Alcântara
authors.forename: P R S
authors.initials: PR
authors.lastname: Alcântara
authors.forename: C R P
authors.initials: CR
authors.lastname: Oliveira
authors.forename: J L M
authors.initials: JL
authors.lastname: Oliveira
authors.forename: F D
authors.initials: FD
authors.lastname: Anjos-Andrade
authors.forename: M I T
authors.initials: MI
authors.lastname: Farias
authors.forename: C T F
authors.initials: CT
authors.lastname: Britto
authors.forename: L M A
authors.initials: LM
authors.lastname: Nóbrega
authors.forename: A C
authors.initials: AC
authors.lastname: Nascimento
authors.forename: É O
authors.initials: ÉO
authors.lastname: Alves
authors.forename: R M C
authors.initials: RM
authors.lastname: Pereira
authors.forename: V C
authors.initials: VC
authors.lastname: Campos
authors.forename: M
authors.initials: M
authors.lastname: Menezes
authors.forename: C E
authors.initials: CE
authors.lastname: Martinelli
authors.forename: M H
authors.initials: MH
authors.lastname: Aguiar-Oliveira
mesh_terms: D000328:Adult; D005260:Female; D006720:Homozygote; D020249:Hormone Replacement Therapy / Q000379:methods*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018013:Receptors, Neuropeptide / Q000235:genetics; D018017:Receptors, Pituitary Hormone-Regulating Hormone / Q000235:genetics; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D016896:Treatment Outcome; D014284:Triiodothyronine / Q000097:blood
chemical_list: D018013:Receptors, Neuropeptide; D018017:Receptors, Pituitary Hormone-Regulating Hormone; D012738:Sex Hormone-Binding Globulin; D014284:Triiodothyronine; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013972:Thyrotropin; C048250:somatotropin releasing hormone receptor; D013974:Thyroxine