title: Interest of fine-needle aspiration cytology in thyroid nodule.
abstract: OBJECTIVE
  The aim of the present study was to evaluate our technique of thyroid fine-needle aspiration cytology (FNAC), its limitations and means of improvement by comparing our results with those of literature.
  
  
  METHODS
  Thyroid FNAC results from 117 consecutive patients (May 2006 to July 2007) were categorized into four groups: benign, with suspected malignancy, malignant and unrepresentative. The FNAC results were compared with histopathologic analysis after thyroidectomy.
  
  
  RESULTS
  All "benign" and "malignant" FNAC findings were confirmed on final histology. All "suspect" FNAC findings were benign on histology. Cytological diagnosis of malignancy was consistent with histological examination in all cases. Sensitivity was 100% (no false negatives), specificity 67% (28% false positives), positive predictive value 72% and negative predictive value 100%. There was a significant difference in the proportion of "unrepresentative" results between two of the operators performing aspiration (51% versus 29.2%).
  
  
  CONCLUSIONS
  The main pitfall of FNAC in thyroid pathology is the "suspect" category, for which positive diagnosis is founded on histological criteria alone. The second limitation identified in this study was the high number of "unrepresentative" aspirates. However, the technique remains useful.
authors.affiliation: Service d'ORL et de Chirurgie Maxillofaciale, CHU la Rabta, 1007 Bab Saadoun, Tunis, Tunisia. Sellami moncef@yahoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Sellami
authors.forename: S
authors.initials: S
authors.lastname: Tababi
authors.forename: J
authors.initials: J
authors.lastname: Mamy
authors.forename: R
authors.initials: R
authors.lastname: Zainine
authors.forename: A
authors.initials: A
authors.lastname: Charfi
authors.forename: N
authors.initials: N
authors.lastname: Beltaief
authors.forename: S
authors.initials: S
authors.lastname: Sahtout
authors.forename: G
authors.initials: G
authors.lastname: Besbes
mesh_terms: D044963:Biopsy, Fine-Needle; D006801:Humans; D011446:Prospective Studies; D016606:Thyroid Nodule / Q000473:pathology*