title: A novel zwitterionic HILIC stationary phase based on "thiol-ene" click chemistry between cysteine and vinyl silica.
abstract: A novel zwitterionic stationary phase with high hydrophilicity was facilely synthesized based on the "thiol-ene" click reaction between cysteine and vinyl silica, which exhibited great potential in the separation of oligosaccharides, peptides and basic compounds, as well as in the enrichment of glycopeptides.
authors.affiliation: Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, PR China.
authors.forename: Aijin
authors.initials: A
authors.lastname: Shen
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Guo
authors.forename: Long
authors.initials: L
authors.lastname: Yu
authors.forename: Liwei
authors.initials: L
authors.lastname: Cao
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Liang
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D057930:Click Chemistry; D003545:Cysteine / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007074:Immunoglobulin G / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D007074:Immunoglobulin G; D013438:Sulfhydryl Compounds; D014753:Vinyl Compounds; D012822:Silicon Dioxide; D003545:Cysteine