title: Psychogenic seizures and frontal disconnection: EEG synchronisation study.
abstract: OBJECTIVE
  Psychogenic non-epileptic seizures (PNES) are paroxysmal events that, in contrast to epileptic seizures, are related to psychological causes without the presence of epileptiform EEG changes. Recent models suggest a multifactorial basis for PNES. A potentially paramount, but currently poorly understood factor is the interplay between psychiatric features and a specific vulnerability of the brain leading to a clinical picture that resembles epilepsy. Hypothesising that functional cerebral network abnormalities may predispose to the clinical phenotype, the authors undertook a characterisation of the functional connectivity in PNES patients.
  
  
  METHODS
  The authors analysed the whole-head surface topography of multivariate phase synchronisation (MPS) in interictal high-density EEG of 13 PNES patients as compared with 13 age- and sex-matched controls. MPS mapping reduces the wealth of dynamic data obtained from high-density EEG to easily readable synchronisation maps, which provide an unbiased overview of any changes in functional connectivity associated with distributed cortical abnormalities. The authors computed MPS maps for both Laplacian and common-average-reference EEGs.
  
  
  RESULTS
  In a between-group comparison, only patchy, non-uniform changes in MPS survived conservative statistical testing. However, against the background of these unimpressive group results, the authors found widespread inverse correlations between individual PNES frequency and MPS within the prefrontal and parietal cortices.
  
  
  CONCLUSIONS
  PNES appears to be associated with decreased prefrontal and parietal synchronisation, possibly reflecting dysfunction of networks within these regions.
authors.affiliation: Deparment of Clinical Neuroscience, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland. maria.knyazeva@chuv.ch
authors.forename: Maria G
authors.initials: MG
authors.lastname: Knyazeva
authors.forename: Mahdi
authors.initials: M
authors.lastname: Jalili
authors.forename: Richard S
authors.initials: RS
authors.lastname: Frackowiak
authors.forename: Andrea O
authors.initials: AO
authors.lastname: Rossetti
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D058407:Electroencephalography Phase Synchronization / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology; D012640:Seizures / Q000503:physiopathology*; D055815:Young Adult