title: Pharmacokinetic-pharmacodynamic reasoning in drug discovery and early development.
authors.forename: Piet H
authors.initials: PH
authors.lastname: Van Der Graaf
authors.forename: Johan
authors.initials: J
authors.lastname: Gabrielsson
mesh_terms: D015195:Drug Design; D055808:Drug Discovery; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics