title: Stem cells: The therapeutic role in the treatment of diabetes mellitus.
abstract: The unlimited proliferative ability and plasticity to generate other cell types ensures that stem cells represent a dynamic system apposite for the identification of new molecular targets and the production and development of novel drugs. These cell lines derived from embryos could be used as a model for the study of basic and applied aspects in medical therapeutics, environmental mutagenesis and disease management. As a consequence, these can be tested for safety or to predict or anticipate potential toxicity in humans. Human ES cell lines may, therefore, prove clinically relevant to the development of safer and more effective drugs for patients presenting with diabetes mellitus.
authors.affiliation: University of Nottingham, Faculty of Medicine and Health Sciences, Insulin Diabetes Experimental Research Group, Clifton Boulevard, Nottingham, UK. Gary.Adams@nottingham.ac.uk
authors.forename: Gary
authors.initials: G
authors.lastname: Adams
authors.forename: Lee
authors.initials: L
authors.lastname: Buttery
authors.forename: Snow
authors.initials: S
authors.lastname: Stolnik
authors.forename: Gordon
authors.initials: G
authors.lastname: Morris
authors.forename: Stephen
authors.initials: S
authors.lastname: Harding
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology; D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D003920:Diabetes Mellitus / Q000628:therapy*; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D051379:Mice