title: The clinical management of hyperemesis gravidarum.
abstract: Hyperemesis gravidarum is a severe and disabling condition with potentially life-threatening complications. It is likely to have a multifactorial etiology which contributes to the difficulty in treatment. Treatment is supportive with correction of dehydration and electrolyte disturbance, antiemetic therapy, prevention and treatment of complications like Wernicke's encephalopathy, osmotic demyelination syndrome, thromboembolism, and good psychological support. There are abundant data on the safety of antihistamines, phenothiazines, and metoclopromide in early pregnancy and treatment should therefore not be withheld on the basis of teratogenicity concerns. Thiamine replacement is indicated in hyperemesis gravidarum to prevent development of Wernicke's encephalopathy.
authors.affiliation: Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India. shipra_s18@rediffmail.com
authors.forename: Shipra
authors.initials: S
authors.lastname: Sonkusare
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000932:Antiemetics / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003711:Demyelinating Diseases / Q000209:etiology / Q000517:prevention & control; D003937:Diagnosis, Differential; D005260:Female; D005440:Fluid Therapy; D020939:Zingiber officinale; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D007231:Infant, Newborn; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome; D012307:Risk Factors; D012944:Social Support; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control; D014899:Wernicke Encephalopathy / Q000209:etiology / Q000517:prevention & control
chemical_list: D000305:Adrenal Cortex Hormones; D000932:Antiemetics; D010936:Plant Extracts