title: Blood vessel deformations on microsecond time scales by ultrasonic cavitation.
abstract: Transient interactions among ultrasound, microbubbles, and microvessels were studied using high-speed photomicrography. We observed liquid jets, vessel distention (motion outward against the surrounding tissue), and vessel invagination (motion inward toward the lumen). Contrary to current paradigms, liquid jets were directed away from the nearest vessel wall and invagination exceeded distention. These observations provide insight into the mechanics of bubble-vessel interactions, which appear to depend qualitatively upon the mechanical properties of biological tissues.
authors.affiliation: Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington 98105, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Wayne
authors.initials: W
authors.lastname: Kreider
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Brayman
authors.forename: Michael R
authors.initials: MR
authors.lastname: Bailey
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Matula
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000000981:diagnostic imaging* / Q000378:metabolism*; D045423:Microbubbles; D010781:Photography; D051381:Rats; D013997:Time Factors; D014463:Ultrasonography