title: Management of hematological malignancies in patients affected by renal failure.
abstract: The management of hematological malignancies (HM) in renally impaired patients may be a difficult task. Indeed, the kidney represents a major elimination pathway for many chemotherapeutic agents and their metabolites, whose serum levels are not usually measured in daily clinical practice. In addition, many antineoplastic drugs have a narrow therapeutic index for which they require dose adjustment when administered to patients with renal failure. Only limited data regarding the use of chemotherapy in patients with renal impairment and in those on dialysis are available. Indeed, renal patients with HM are often excluded from most clinical trials. Thus far, in order to provide recommendations, we have reviewed the pertinent literature, gathering information from published guidelines regarding chemotherapy in patients with kidney dysfunction and from articles describing the use of individual agents in renal patients with HM.
authors.affiliation: Hematology Unit, S Eugenio Hospital, Rome, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Niscola
authors.forename: Gisella
authors.initials: G
authors.lastname: Vischini
authors.forename: Andrea
authors.initials: A
authors.lastname: Tendas
authors.forename: Laura
authors.initials: L
authors.lastname: Scaramucci
authors.forename: Marco
authors.initials: M
authors.lastname: Giovannini
authors.forename: Francesco
authors.initials: F
authors.lastname: Bondanini
authors.forename: Claudio
authors.initials: C
authors.lastname: Romani
authors.forename: Gregorio Antonio
authors.initials: GA
authors.lastname: Brunetti
authors.forename: Claudio
authors.initials: C
authors.lastname: Cartoni
authors.forename: Luca
authors.initials: L
authors.lastname: Cupelli
authors.forename: Michele
authors.initials: M
authors.lastname: Ferrannini
authors.forename: Alessio
authors.initials: A
authors.lastname: Perrotti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Del Poeta
authors.forename: Roberto
authors.initials: R
authors.lastname: Palumbo
authors.forename: Paolo
authors.initials: P
authors.lastname: de Fabritiis
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D051437:Renal Insufficiency / Q000150:complications*
chemical_list: D000970:Antineoplastic Agents