title: [Histone deacetylase 6: the key regulator of misfolded proteins].
abstract: Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes. It deacetylates alpha-tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. When the misfolded proteins are too more to be degradated by the chaperone refolding system and the ubiquitin-proteasome system in cultured cells, misfolded proteins are specifically transported to a cytoplasmic juxtanuclear structure called aggresome by HDAC6, facilitating their clearance by autophagy. The diverse functions of HDAC6 in misfolded proteins degradation pathway suggest that it is a potential therapeutic target for the treatment of "conformational diseases".
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
authors.forename: Min
authors.initials: M
authors.lastname: Su
authors.forename: Xue
authors.initials: X
authors.lastname: Sun
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Liu
mesh_terms: D001343:Autophagy / Q000502:physiology; D051356:Cortactin / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases / Q000502:physiology*; D006801:Humans; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D057165:Proteostasis Deficiencies / Q000378:metabolism*; D014404:Tubulin / Q000378:metabolism
chemical_list: D051356:Cortactin; D018841:HSP90 Heat-Shock Proteins; D011506:Proteins; D014404:Tubulin; C433811:HDAC6 protein, human; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases