title: Hysteroscopic dynamic assessment of the endometrium in patients treated with long-term tamoxifen.
abstract: OBJECTIVE
  To describe the evolutive endometrial hysteroscopic patterns in patients undergoing long-term tamoxifen treatment.
  
  
  METHODS
  Prospective analysis. Analysis of variance test with post hoc Bonferroni test and homogeneity test of percentages were used for hypothesis contrast between the groups.
  
  
  METHODS
  Canadian task force II-2.
  
  
  METHODS
  Four Spanish tertiary care hospitals.
  
  
  METHODS
  A total of 278 patients with breast cancer diagnosed between 2002 and 2004, which completed 5-years adjuvant therapy with tamoxifen.
  
  
  METHODS
  Ultrasonography and hysteroscopic explorations were performed before starting the treatment and then at yearly intervals during the 5 years of adjuvant treatment.
  
  
  RESULTS
  Hysteroscopic endometrial changes were significant throughout the years of treatment. Tamoxifen-exposed endometria present five different patterns: atrophic, cystic, hypervascularized, endometrial polyp, and suspicious of malignancy. Endometrial carcinoma appeared in four patients (1.5%) that bled during the follow-up.
  
  
  CONCLUSIONS
  Tamoxifen produces five different endometrial patterns that evolve dynamically throughout the 5 years of treatment.
authors.affiliation: Obstetrics Department, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Madrid, Spain. tperezm@sego.es
authors.forename: Tirso
authors.initials: T
authors.lastname: Pérez-Medina
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Salazar
authors.forename: Luis
authors.initials: L
authors.lastname: San-Frutos
authors.forename: Mar
authors.initials: M
authors.lastname: Ríos
authors.forename: Jesús S
authors.initials: JS
authors.lastname: Jiménez
authors.forename: Juan
authors.initials: J
authors.lastname: Troyano
authors.forename: Enrique
authors.initials: E
authors.lastname: Cayuela
authors.forename: Enrique
authors.initials: E
authors.lastname: Iglesias
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001284:Atrophy; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D016889:Endometrial Neoplasms / Q000139:chemically induced / Q000473:pathology; D004717:Endometrium / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008875:Middle Aged; D011446:Prospective Studies; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen