title: Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes.
abstract: A novel class of paramagnetic liposome-based systems acting as dual T(1) and CEST (1)H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T(1) contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.
authors.affiliation: Department of Chemistry IFM and Molecular & Preclinical Imaging Centres, University of Torino, via Nizza 52, 10126, Torino, Italy. enzo.terreno@unito.it
authors.forename: Enzo
authors.initials: E
authors.lastname: Terreno
authors.forename: Cinzia
authors.initials: C
authors.lastname: Boffa
authors.forename: Valeria
authors.initials: V
authors.lastname: Menchise
authors.forename: Franco
authors.initials: F
authors.lastname: Fedeli
authors.forename: Carla
authors.initials: C
authors.lastname: Carrera
authors.forename: Daniela Delli
authors.initials: DD
authors.lastname: Castelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Digilio
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D015335:Molecular Probes / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011522:Protons
chemical_list: D003287:Contrast Media; D008081:Liposomes; D015335:Molecular Probes; D009942:Organometallic Compounds; D011522:Protons; D005682:Gadolinium