title: Chemical composition, antioxidant properties and anti-cholinesterase activity of Cordia gilletii (Boraginaceae) leaves essential oil.
abstract: This study aimed to investigate for the first time the chemical composition, the antioxidant properties and the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity of the essential oil from the leaves of Cordia gilletii De Wild (Boraginaceae). The essential oil, characterized by 23 constituents (90.1% of the total oil), was constituted by terpene derivatives (25.6%) and non-terpene derivatives (64.5%), among which aldehydes, fatty acids and alkanes were present with the percentage of 16.5%, 18.8% and 23.1%, respectively. The antioxidant activity of C. gilletii essential oil was screened by two in vitro tests: DPPH and beta-carotene bleaching test. The essential oil revealed antioxidant activity with an IC50 value of 75.0 and 129.9 microg/mL on DPPH radical and beta-carotene decoloration tests, respectively. Moreover, C. gilletii inhibited AChE enzyme with an IC50 value of 105.6 microg/mL.
authors.affiliation: Faculty of Pharmacy, Nutrition and Health Sciences, Department of Pharmaceutical Sciences, University of Calabria, 1-87036 Rende (CS), Italy. bonesi@unical.it
authors.forename: Marco
authors.initials: M
authors.lastname: Bonesi
authors.forename: Philippe N
authors.initials: PN
authors.lastname: Okusa
authors.forename: Rosa
authors.initials: R
authors.lastname: Tundis
authors.forename: Monica R
authors.initials: MR
authors.lastname: Loizzo
authors.forename: Federica
authors.initials: F
authors.lastname: Menichini
authors.forename: Caroline
authors.initials: C
authors.lastname: Stévigny
authors.forename: Pierre
authors.initials: P
authors.lastname: Duez
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichini
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D031213:Cordia / Q000737:chemistry*; D009822:Oils, Volatile / Q000032:analysis* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D009822:Oils, Volatile