title: [The significance of bleeding disorders in patients with epistaxis].
abstract: BACKGROUND
  Epistaxis can have a variety of different local or systemic causes. It is the cardinal symptom of von Willebrand disease (VWD), the most frequent congenital bleeding disorder with a prevalence of approximately 1%. The usual routine coagulation screening tests (PT, APTT, platelet count) are not sufficient to diagnose VWD, factor XIII (FXIII)-deficiency or platelet dysfunction.
  
  
  METHODS
  A prospective study was conducted implementing enhanced coagulation screening for bleeding disorders in a total of 100 inpatients admitted for epistaxis.
  
  
  RESULTS
  A bleeding disorder was found in 13%. In eight patients VWD was diagnosed, in six patients FXIII-deficiency was found, and in one patient both.
  
  
  CONCLUSIONS
  The prevalence of bleeding disorders in patients with epistaxis is higher than in the general population. Epistaxis can be the primary symptom of chronic inflammatory disease or malignant disease. A thorough anamnesis is necessary and in cases of doubt additional testing for underlying disorders is recommended.
authors.affiliation: Klinik für Hals-, Nasen-, Ohrenheilkunde, Universitätsmedizin Mainz, Langenbeckstrasse 1, 55131, Mainz, Deutschland. taeumer@hno.klinik.uni-mainz.de
authors.forename: T
authors.initials: T
authors.lastname: Taeumer
authors.forename: A
authors.initials: A
authors.lastname: de Greiff
authors.forename: I
authors.initials: I
authors.lastname: Scharrer
authors.forename: K
authors.initials: K
authors.lastname: Papaspyrou
authors.forename: T
authors.initials: T
authors.lastname: Mewes
authors.forename: W
authors.initials: W
authors.lastname: Mann
mesh_terms: D000328:Adult; D000368:Aged; D001780:Blood Coagulation Tests / Q000706:statistics & numerical data*; D015897:Comorbidity; D004844:Epistaxis / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D014842:von Willebrand Diseases / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*