title: Solution-phase parallel synthesis of a diverse library of 1,2-dihydroisoquinolines.
abstract: Synthesis of a 105 membered library of 1,2-dihydroisoquinolines is described. The 1,2-dihydroisoquinoline compounds have been prepared in good yields using a Lewis acid and organocatalyst-cocatalyzed multicomponent reaction of 2-(1-alkynyl)benzaldehydes, amines, and ketones. Various indoles have also been employed as pronucleophiles, furnishing 1-(3-indolyl)-1,2-dihydroisoquinolines. The halogen functionality present in some of the synthesized compounds allows for further diversification by palladium-catalyzed Suzuki−Miyaura and Sonogashira cross-couplings to give more diversified 1,2-dihydroisoquinoline derivatives.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States.
authors.forename: Nataliya A
authors.initials: NA
authors.lastname: Markina
authors.forename: Raffaella
authors.initials: R
authors.lastname: Mancuso
authors.forename: Benjamin
authors.initials: B
authors.lastname: Neuenswander
authors.forename: Gerald H
authors.initials: GH
authors.lastname: Lushington
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
mesh_terms: D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C109853:G 1617; D007546:Isoquinolines