title: Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices.
abstract: This paper presents the outcomes from a workshop of the European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet). During the workshop, 45 experts in the field of safety assessment of engineered nanomaterials addressed the need to systematically study sets of engineered nanomaterials with specific metrics to generate a data set which would allow the establishment of dose-response relations. The group concluded that international cooperation and worldwide standardization of terminology, reference materials and protocols are needed to make progress in establishing lists of essential metrics. High quality data necessitates the development of harmonized study approaches and adequate reporting of data. Priority metrics can only be based on well-characterized dose-response relations derived from the systematic study of the bio-kinetics and bio-interactions of nanomaterials at both organism and (sub)-cellular levels. In addition, increased effort is needed to develop and validate analytical methods to determine these metrics in a complex matrix.
authors.affiliation: RIKILT - Institute of Food Safety, Wageningen UR, Wageningen, The Netherlands. hans.bouwmeester@wur.nl
authors.forename: Hans
authors.initials: H
authors.lastname: Bouwmeester
authors.forename: Iseult
authors.initials: I
authors.lastname: Lynch
authors.forename: Hans J P
authors.initials: HJ
authors.lastname: Marvin
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Dawson
authors.forename: Markus
authors.initials: M
authors.lastname: Berges
authors.forename: Diane
authors.initials: D
authors.lastname: Braguer
authors.forename: Hugh J
authors.initials: HJ
authors.lastname: Byrne
authors.forename: Alan
authors.initials: A
authors.lastname: Casey
authors.forename: Gordon
authors.initials: G
authors.lastname: Chambers
authors.forename: Martin J D
authors.initials: MJ
authors.lastname: Clift
authors.forename: Giuliano
authors.initials: G
authors.lastname: Elia
authors.forename: Teresa F
authors.initials: TF
authors.lastname: Fernandes
authors.forename: Lise B
authors.initials: LB
authors.lastname: Fjellsbø
authors.forename: Peter
authors.initials: P
authors.lastname: Hatto
authors.forename: Lucienne
authors.initials: L
authors.lastname: Juillerat
authors.forename: Christoph
authors.initials: C
authors.lastname: Klein
authors.forename: Wolfgang G
authors.initials: WG
authors.lastname: Kreyling
authors.forename: Carmen
authors.initials: C
authors.lastname: Nickel
authors.forename: Michael
authors.initials: M
authors.lastname: Riediker
authors.forename: Vicki
authors.initials: V
authors.lastname: Stone
mesh_terms: D003245:Consensus Statements as Topic; D004305:Dose-Response Relationship, Drug; D015386:Hazardous Substances / Q000592:standards / Q000633:toxicity*; D008420:Manufactured Materials / Q000592:standards / Q000633:toxicity; D049329:Nanostructures / Q000737:chemistry / Q000592:standards / Q000633:toxicity*; D010316:Particle Size; D018570:Risk Assessment; D013499:Surface Properties
chemical_list: D015386:Hazardous Substances