title: Double vision: pigment genes do more than just color.
abstract: The use of P element collections led to the discovery of unanticipated effects from common genetic background mutants white, brown, and rosy in our previously reported model of tauopathy that expresses full-length human tau in the fly eye, in which mutant rosy suppresses mutant white and brown worsening of tau-induced toxicity (Ambegaokar & Jackson, 2010, Genetics, v. 186, p. 435-42). Here we discuss further possible effects of mini-white and evidence for autophagy as a mediator of white enhancement of tau toxicity.
authors.affiliation: Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Surendra S
authors.initials: SS
authors.lastname: Ambegaokar
authors.forename: George
authors.initials: G
authors.lastname: Jackson
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics*; D003116:Color; D054910:Compound Eye, Arthropod / Q000502:physiology*; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D010860:Pigments, Biological / Q000235:genetics* / Q000378:metabolism; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D010860:Pigments, Biological; D016875:tau Proteins