title: Uptake, tissue distribution and metabolism of the insecticide endosulfan in Jenynsia multidentata (Anablepidae, Cyprinodontiformes).
abstract: The study reports the accumulation, distribution and metabolism of technical endosulfan in Jenynsia multidentata. Adult females were exposed to acute sublethal concentrations (0.072, 0.288 and 1.4 μg L⁻¹). After 24 h, fish were sacrificed and gills, liver, brain, intestine and muscle were removed. Results show that both isomers of technical-grade endosulfan (α- and β-) are accumulated in fish tissues and biotransformation to endosulfan sulfate occurs at all concentrations tested. Significantly differences in endosulfan accumulation were only found at 1.4 μg L⁻¹ but not between the lowest concentrations. However a similar distribution pattern was observed at all exposure levels where liver, intestine and brain had the highest levels of α-, β-endosulfan and endosulfan sulfate. Moreover, liver and brain showed the highest endosulfan sulfate:α-endosulfan ratios due to high biotransfomation capacity. J. multidentata demonstrated to be a sensitive species under exposure to technical endosulfan and, therefore, could be used to assess aquatic pollution.
authors.affiliation: Universidad Nacional de Córdoba, Facultad de Ciencias Exactas Físicas y Naturales, Cátedra Diversidad Animal II, Av. Vélez Sársfield 299, 5000 Córdoba, Argentina. mlballesteros@efn.uncor.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Ballesteros
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez
authors.forename: D A
authors.initials: DA
authors.lastname: Wunderlin
authors.forename: M A
authors.initials: MA
authors.lastname: Bistoni
authors.forename: K S B
authors.initials: KS
authors.lastname: Miglioranza
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D003532:Cyprinodontiformes / Q000378:metabolism*; D004726:Endosulfan / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005880:Gills / Q000378:metabolism; D007306:Insecticides / Q000032:analysis / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000378:metabolism*
chemical_list: D007306:Insecticides; D014874:Water Pollutants, Chemical; D004726:Endosulfan