title: Conjugate (MTC-220) of muramyl dipeptide analogue and paclitaxel prevents both tumor growth and metastasis in mice.
abstract: 1 (MTC-220), a conjugate of paclitaxel and a muramyl dipeptide analogue, has been synthesized as a novel agent of dual antitumor growth and metastasis activities. In vitro and in vivo tests show that 1 retains its ability to inhibit tumor growth. It is superior to paclitaxel in its ability to prevent tumor metastasis in Lewis lung carcinoma and 4T1-tumor-bearing mice. The present studies indicate that 1 suppresses myeloid derived suppressor cell accumulation in the spleen and bone marrow of tumor-bearing mice and also represses inflammatory cytokines in tumor tissue. These results demonstrated that 1 could be a potential therapeutic and preventive agent for cancer growth and metastasis.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Xicheng District, Beijing, P R China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Ma
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018827:Carcinoma, Lewis Lung / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D016207:Cytokines / Q000378:metabolism; D004151:Dipeptides / Q000494:pharmacology*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D004151:Dipeptides; D018836:Inflammation Mediators; C582620:MTC-220; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D017239:Paclitaxel