title: [Advances in mitochondrial fusion-fission and Ca2+ signaling in mammals].
abstract: Mitochondria are dynamic organelles and maintain their structure through two opposing processes of fusion and fission. In mammals, there are many factors which influence the equilibrium between mitochondrial fusion and fission. It has been known that mitochondrial fusion is controlled by mitochondria-shaping proteins, including the large GTPase mitofusins (Mfn1/2) and optic atrophy protein 1 (OPA1), whereas the protein Fis1 and dynamin-related protein 1 (Drp1) are the key mediators of mitochondrial fission. Recent data revealed the relationship between mitochondrial fusion/fission and Ca2+ signaling. Ca2+ handling is controlled by the change of mitochondrial fission-fusion balance. On the other hand, intra- and near-mitochondrial Ca2+ signals can modify mitochondrial morphology and cellular distribution.
authors.affiliation: Emergency Department, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Guang-Ju
authors.initials: GJ
authors.lastname: Zhao
authors.forename: Zhong-Qiu
authors.initials: ZQ
authors.lastname: Lu
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yao
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D034281:Dynamins; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D008561:Membrane Fusion; D008565:Membrane Proteins / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D051336:Mitochondrial Membranes / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism
chemical_list: C476525:FIS1 protein, human; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D020558:GTP Phosphohydrolases; C470018:MFN2 protein, human; C415198:OPA1 protein, human; C110768:DNM1L protein, human; D034281:Dynamins; D002118:Calcium