title: Vascular tissue engineering: towards the next generation vascular grafts.
abstract: The application of tissue engineering technology to cardiovascular surgery holds great promise for improving outcomes in patients with cardiovascular diseases. Currently used synthetic vascular grafts have several limitations including thrombogenicity, increased risk of infection, and lack of growth potential. We have completed the first clinical trial evaluating the feasibility of using tissue engineered vascular grafts (TEVG) created by seeding autologous bone marrow-derived mononuclear cells (BM-MNC) onto biodegradable tubular scaffolds. Despite an excellent safety profile, data from the clinical trial suggest that the primary graft related complication of the TEVG is stenosis, affecting approximately 16% of grafts within the first seven years after implantation. Continued investigation into the cellular and molecular mechanisms underlying vascular neotissue formation will improve our basic understanding and provide insights that will enable the rationale design of second generation TEVG.
authors.affiliation: Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, 10 Amistad Street, New Haven, CT 06520, USA
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Shinoka
authors.forename: Daniel
authors.initials: D
authors.lastname: Duncan
authors.forename: Narutoshi
authors.initials: N
authors.lastname: Hibino
authors.forename: Daniel
authors.initials: D
authors.lastname: Solomon
authors.forename: Muriel
authors.initials: M
authors.lastname: Cleary
authors.forename: Animesh
authors.initials: A
authors.lastname: Rathore
authors.forename: Corey
authors.initials: C
authors.lastname: Fein
authors.forename: Spencer
authors.initials: S
authors.lastname: Church
authors.forename: Christopher
authors.initials: C
authors.lastname: Breuer
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis / Q000639:trends*; D019917:Blood Vessel Prosthesis Implantation / Q000639:trends; D002318:Cardiovascular Diseases / Q000601:surgery*; D006083:Graft Occlusion, Vascular / Q000453:epidemiology; D006801:Humans; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D054457:Tissue Scaffolds / Q000639:trends