title: Potential of using boric acid as a boron drug for boron neutron capture therapy for osteosarcoma.
abstract: Osteosarcoma is a malignant tumor commonly found in human and animals. The ability of boric acid (BA) to accumulate in osteosarcoma due to the mechanism of the bone formation of cancer cells would make boron neutron capture therapy (BNCT) an alternative therapy for osteosarcoma. This study evaluated the feasibility of using BA as the boron drug for BNCT of bone cancer. The cytotoxicity of BA to L929 cells exceeded that of UMR-106 cells. With 25 μg (10)B/mL medium of BA treatment, the boron concentration in UMR-106 cells was higher than that in L929 cells. The biodistribution and pharmacokinetics of BA in Sprague-Dawley (SD) rats were studied by administrating 25 mg (10)B/kg body weight to SD rats. Blood boron level decreased rapidly within one hour after BA injection. Boron concentration in the long bone was 4-6 time higher than that of blood. Results of this study suggest that BA may be a potential drug for BNCT for osteosarcoma.
authors.affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, Taiwan, ROC.
authors.forename: C F
authors.initials: CF
authors.lastname: Hsu
authors.forename: S Y
authors.initials: SY
authors.lastname: Lin
authors.forename: J J
authors.initials: JJ
authors.lastname: Peir
authors.forename: J W
authors.initials: JW
authors.lastname: Liao
authors.forename: Y C
authors.initials: YC
authors.lastname: Lin
authors.forename: F I
authors.initials: FI
authors.lastname: Chou
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000532:radiotherapy*; D001888:Boric Acids / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy; D045744:Cell Line, Tumor; D008297:Male; D012516:Osteosarcoma / Q000532:radiotherapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D001888:Boric Acids; C032688:boric acid