title: Renal function improvement with pentavalent antimonial agents in patients with visceral leishmaniasis.
abstract: BACKGROUND
  The aim of this study is to investigate tubular and glomerular function after visceral leishmaniasis (VL) treatment with pentavalent antimonials.
  
  
  METHODS
  This is a prospective study including 14 patients with VL diagnosis treated with pentavalent antimonials. Urine acidification and concentration tests were performed. Estimated glomerular filtration rate (eGFR), fractional excretion of sodium (FE(Na)) and potassium (FE(K)) and free water clearance (C(H2O)) were measured to assess glomerular and tubular function.
  
  
  RESULTS
  The VL group had a significantly lower FE(K), serum sodium and plasma osmolality (P(osm)). No significant differences were found regarding proteinuria, eGFR, FE(Na) or C(H2O). Patients in the VL group had lower urinary osmolality (U(osm)) before DDAVP use when compared to the control group, as well as a lower U/P(osm). The urinary pH before and after CaCl(2) load was higher in the VL group.
  
  
  CONCLUSIONS
  This study shows evidence of reversal of some tubular dysfunction in VL, but other dysfunctions may persist, especially urinary acidification capacity.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Federal University of Ceará, Fortaleza, Brazil. ef.daher@uol.com.br
authors.forename: Elizabeth F
authors.initials: EF
authors.lastname: Daher
authors.forename: Natália A
authors.initials: NA
authors.lastname: Rocha
authors.forename: Michelle J C
authors.initials: MJ
authors.lastname: Oliveira
authors.forename: Luiz F L G
authors.initials: LF
authors.lastname: Franco
authors.forename: Jobson L
authors.initials: JL
authors.lastname: Oliveira
authors.forename: Geraldo B
authors.initials: GB
authors.lastname: Silva Junior
authors.forename: Krasnalhia Lívia S
authors.initials: KL
authors.lastname: Abreu
authors.forename: Guilherme A L
authors.initials: GA
authors.lastname: Henn
authors.forename: Alice M C
authors.initials: AM
authors.lastname: Martins
authors.forename: Alexandre B
authors.initials: AB
authors.lastname: Libório
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000378:metabolism* / Q000502:physiology*; D007677:Kidney Function Tests; D007898:Leishmaniasis, Visceral / Q000378:metabolism* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism; D011446:Prospective Studies; D012964:Sodium / Q000737:chemistry / Q000378:metabolism
chemical_list: D012964:Sodium; D011188:Potassium