title: Adenovirus infection with serious pulmonary sequelae in Korean children.
abstract: BACKGROUND
  Varying clinical progress and long-term pulmonary sequelae have been associated with different adenoviral serotypes.
  
  
  OBJECTIVE
  The purpose of this study was to determine the association between serotype and clinical profiles of pediatric adenoviral pneumonia cases that occurred in Korea from 1996-1998.
  
  
  METHODS
  Nasopharyngeal aspirate samples from 44 adenovirus-positive patients presenting with acute severe respiratory disease were sent to reference laboratories for serotyping. Clinical course and chest X-rays were analyzed during the acute phase, and HRCTs were performed during the convalescent phase to identify long-term pulmonary complications.
  
  
  RESULTS
  Ad-7 was associated with the most severe clinical course and resultant long-term pulmonary sequelae, followed by milder clinical course and lower frequency of sequelae in Ad-3 cases, and even milder outcomes in children infected with Ad-5.
  
  
  CONCLUSIONS
  In complicated adenoviral pneumonia, certain serotypes prevail with Ad-7 being the most severe. Continued serotyping with the eventual goal of creating a database for the early diagnosis, treatment and prognostication of adenoviral pneumonia is needed.
authors.affiliation: Asthma and Allergy Center, Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
authors.forename: Zak
authors.initials: Z
authors.lastname: Callaway
authors.forename: Soung Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Jung Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Kim
authors.forename: Chang-Keun
authors.initials: CK
authors.lastname: Kim
mesh_terms: D000256:Adenoviridae / Q000302:isolation & purification*; D000258:Adenovirus Infections, Human / Q000175:diagnosis*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D056910:Republic of Korea; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000821:virology*