title: [The physiological and pathological significance of epigenetic regulation in neural development].
abstract: Epigenetics refers to changes in gene expression that do not entail a change in DNA sequence, namely phenotype changed, other than the genotype. These changes may remain through cell division for the remainder of the cell's life and may also last for multiple generations. It contains DNA methylation, histone modification, chromatin remodeling, gene imprinting and so on. Methylation is one of the chief epigenetic modify patterns in genomic DNA. DNA methylation via the interaction of methylation-CpG-binding proteins will affect the gene expression. Furthermore, the dysfuction of epigenetic mechanisms may lead to multiple genetic neurodevelopmental disorders and degenerative diseases. Here we mainly rewiewed the physiological and pathological significance of epigenetics regulations in neural development and neurodegeneration.
authors.affiliation: Department of Neurobiology and State Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Li
authors.forename: Feng-Yan
authors.initials: FY
authors.lastname: Sun
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000235:genetics; D002455:Cell Division; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000502:physiology*; D005600:Fragile X Syndrome / Q000235:genetics; D006801:Humans; D051783:Methyl-CpG-Binding Protein 2 / Q000502:physiology*; D009420:Nervous System / Q000254:growth & development*; D009474:Neurons / Q000166:cytology
chemical_list: D051783:Methyl-CpG-Binding Protein 2