title: The triplet puzzle of homologies in receptor heteromers exists also in other types of protein-protein interactions.
abstract: Based on our theory, we point out main triplets of amino acid residues in the GABAB1 receptor, found in the central and peripheral nervous system, which seem to be critical for both receptor heterodimerization and chemokine binding. The obtained results suggest that these triplets may "guide-and-clasp" protein-protein interactions playing a role, e.g., in neuroinflammation disorders.
authors.affiliation: St. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences. tar@iias.spb.su
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Tarakanov
authors.forename: Kjell G
authors.initials: KG
authors.lastname: Fuxe
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs / Q000235:genetics*; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D055503:Protein Multimerization; D018080:Receptors, GABA-B / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment
chemical_list: D020033:Protein Isoforms; D018080:Receptors, GABA-B