title: A severely immunocompromised child with uncomplicated oseltamivir-resistant 2009 H1N1 pandemic influenza infection.
abstract: 2009 H1N1 pandemic influenza was associated with increased risk for severe disease in children and the immunosuppressed. We report a case of uncomplicated pneumonia because of infection with oseltamivir-resistant 2009 H1N1 virus in an immunosuppressed pediatric renal transplant patient. Innate immunity and/or altered viral fitness may be responsible for the mild clinical phenotype of the case.
authors.affiliation: Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. ehyle@partners.org
authors.forename: Emily P
authors.initials: EP
authors.lastname: Hyle
authors.forename: Bo
authors.initials: B
authors.lastname: Shu
authors.forename: Stephen
authors.initials: S
authors.lastname: Lindstrom
authors.forename: Alexander
authors.initials: A
authors.lastname: Klimov
authors.forename: Kathy
authors.initials: K
authors.lastname: Hancock
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Ferraro
authors.forename: Avram Z
authors.initials: AZ
authors.lastname: Traum
authors.forename: Ian C
authors.initials: IC
authors.lastname: Michelow
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D024882:Drug Resistance, Viral; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000302:isolation & purification; D007251:Influenza, Human / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D016030:Kidney Transplantation; D053139:Oseltamivir / Q000494:pharmacology / Q000627:therapeutic use*; D011024:Pneumonia, Viral / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir