title: A brief history of TOR.
abstract: The TOR (target of rapamycin) serine/threonine kinases are fascinating in that they influence many different aspects of eukaryote physiology including processes often dysregulated in disease. Beginning with the initial characterization of rapamycin as an antifungal agent, studies with yeast have contributed greatly to our understanding of the molecular pathways in which TORs operate. Recently, building on advances in quantitative MS, the rapamycin-dependent phosphoproteome in the budding yeast Saccharomyces cerevisiae was elucidated. These studies emphasize the central importance of TOR and highlight its many previously unrecognized functions. One of these, the regulation of intermediary metabolism, is discussed.
authors.affiliation: Department of Molecular Biology, National Centres of Competence in Research Frontiers in Genetics and Chemical Biology, University of Geneva, Sciences III, 30 quai Ernest Ansermet, CH-1211 Geneva, Switzerland. Robbie.Loewith@unige.ch
authors.forename: Robbie
authors.initials: R
authors.lastname: Loewith
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis; D000818:Animals; D049673:History, 20th Century; D006801:Humans; D008967:Molecular Biology / Q000266:history* / Q000639:trends; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology*; D020123:Sirolimus / Q000378:metabolism / Q000494:pharmacology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
chemical_list: D000596:Amino Acids; C500984:CRTC1 protein, human; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D017346:Protein Serine-Threonine Kinases; C500749:target of rapamycin protein, S cerevisiae; D020123:Sirolimus