title: Postoperative endophthalmitis caused by Candida parapsilosis: clinical features and treatment outcomes.
abstract: Three consecutive patients with postoperative Candida parapsilosis endophthalmitis presented from a single surgeon and surgery center after uncomplicated cataract surgery. All patients were treated with pars plana vitrectomy (PPV), intraocular lens removal, total capsulectomy, and intraoperative injection of intravitreal antifungal agent. Intraoperative cultures of undiluted vitreous and lens capsule were all positive for the fungus. All patients also received oral antifungal agents postoperatively. Two of these patients received several serial intravitreal antifungal injections after PPV. Following these treatments, all infections were resolved and vision outcomes were favorable at last follow-up.
authors.affiliation: New England Retina Associates, Hamden, CT 06518, USA. neretina@msn.com
authors.forename: Richard
authors.initials: R
authors.lastname: Scartozzi
authors.forename: David
authors.initials: D
authors.lastname: Tom
authors.forename: Peter E
authors.initials: PE
authors.lastname: Liggett
authors.forename: Harry W
authors.initials: HW
authors.lastname: Flynn
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D002387:Cataract Extraction; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D019591:Pseudophakia / Q000209:etiology; D011743:Pyrimidines / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D014792:Visual Acuity; D014821:Vitrectomy; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole