title: Crystal storing histiocytosis of the tongue as the initial presentation of multiple myeloma.
abstract: Crystal-storing histiocytosis (CSH) is a rare consequence of abnormal accumulation of immunoglobulins which may arise in a number of different clinical scenarios. In this report, we describe the case of a male patient who presented with an apparently innocuous lesion on the dorsum of tongue which showed the typical features of CSH. Subsequent investigations revealed an associated plasmacytoma, and the patient developed further systemic lesions. The rarity of such lesions presents diagnostic difficulties, yet accurate diagnosis underpins the timely implementation of appropriate therapy.
authors.affiliation: Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Syed Ali
authors.initials: SA
authors.lastname: Khurram
authors.forename: Allan
authors.initials: A
authors.lastname: McPhaden
authors.forename: W Stewart
authors.initials: WS
authors.lastname: Hislop
authors.forename: Keith D
authors.initials: KD
authors.lastname: Hunter
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D003460:Crystallization; D003937:Diagnosis, Differential; D015614:Histiocytosis / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007147:Immunoglobulin Light Chains / Q000096:biosynthesis; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis*; D010950:Plasma Cells / Q000378:metabolism; D010954:Plasmacytoma / Q000473:pathology* / Q000532:radiotherapy; D014062:Tongue Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; C067980:CD68 antigen, human; D000097382:CD68 Molecule