title: Targeting HIV: past, present and future.
abstract: Since the identification of the human immunodeficiency virus (HIV) as the cause of the syndrome of acquired immunodeficiency syndrome (AIDS), there has been an evolution of compounds targeting the replication of the virus in an effort to delay clinical progression. In this review, we revise the mechanism of action of the different groups of drugs. We shortly revisit the older and perhaps lesser used as well as the more recently approved drugs and mention some of the compounds still under investigation.
authors.affiliation: Department of Internal Medicine (Infectious Diseases), University of Stellenbosch and Tygerberg Hospital, Parow 7505, Cape Town, South Africa. mdz@sun.ac.za
authors.forename: Michèle D
authors.initials: MD
authors.lastname: Zeier
authors.forename: Jean B
authors.initials: JB
authors.lastname: Nachega
mesh_terms: D019380:Anti-HIV Agents / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans
chemical_list: D019380:Anti-HIV Agents