title: Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients.
abstract: The association between HLA polymorphisms and PTLD was investigated in a case-control study, comparing 110 predominantly adult solid-organ transplant recipients who developed PTLD to 5601 who did not. Donor and recipient HLA were analyzed. We detected a significant association between recipient HLA-A26 and the development of PTLD (OR 2.74; p = 0.0007). In Caucasian recipients, both recipient and donor HLA-A26 were independently associated with development of PTLD (recipient A26 OR 2.99; p = 0.0004, donor A26 OR 2.81; p = 0.002). Analysis of HLA-A and -B haplotypes revealed that recipient HLA-A26, B38 haplotype was strongly correlated with a higher incidence of EBV-positive PTLD (OR 3.99; p = 0.001). The common ancestral haplotype HLA-A1, B8, DR3, when carried by the donor, was protective against PTLD (OR 0.41; p = 0.05). Several other HLA specificities demonstrated associations with clinical and pathological characteristics as well as survival. These findings demonstrate the importance of HLA polymorphisms in modulating the risk for PTLD, and may be useful in risk stratification and development of monitoring and prophylaxis strategies.
authors.affiliation: Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. ran.reshef@uphs.upenn.edu
authors.forename: R
authors.initials: R
authors.lastname: Reshef
authors.forename: M R
authors.initials: MR
authors.lastname: Luskin
authors.forename: M
authors.initials: M
authors.lastname: Kamoun
authors.forename: S
authors.initials: S
authors.lastname: Vardhanabhuti
authors.forename: J E
authors.initials: JE
authors.lastname: Tomaszewski
authors.forename: E A
authors.initials: EA
authors.lastname: Stadtmauer
authors.forename: D L
authors.initials: DL
authors.lastname: Porter
authors.forename: D F
authors.initials: DF
authors.lastname: Heitjan
authors.forename: De E
authors.initials: de E
authors.lastname: Tsai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006085:Graft Survival; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D006680:HLA Antigens