title: Comparison of Doppler flow Tei-indexes with pulmonary artery thermodilution measurement of cardiac output in an experimental porcine model.
abstract: The objective of our study was to compare Doppler echocardiography imaging with pulmonary artery thermodilution measurement during mechanical ventilation. Total 78 piglets (6 weeks old, average weight 24 kg, under general anesthesia) were divided into 4 groups under different cardiac loading conditions (at rest, with increased left ventricular afterload, with increased right ventricular preload, and with increased afterload of both heart ventricles). At 60 and 120 min the animals were examined by echocardiography and simultaneously pulmonary artery thermodilution was used to measure cardiac output. Tei-indexes data were compared with invasively monitored hemodynamic data and cardiac output values together with calculated vascular resistance indices. A total of 224 parallel measurements were obtained. Correlation was found between values of right Tei-index of myocardial performance and changes in right ventricular preload (p<0.05) and afterload (p<0.01). Significant correlation was also found between left index values and changes of left ventricular preload (p<0.001), afterload (p<0.001), stroke volume (p<0.01), and cardiac output (p<0.01). In conclusion, echocardiographic examination and determination of the global performance selectively for the right and left ventricle can be recommended as a suitable non-invasive supplement to the whole set of methods used for monitoring of circulation and cardiac performance.
authors.affiliation: Department of Paediatrics – Pediatric Intensive Care Unit, Charles University in Prague, Faculty of Medicine in Pilsen, Czech Republic. kobr@fnplzen.cz
authors.forename: J
authors.initials: J
authors.lastname: Kobr
authors.forename: V
authors.initials: V
authors.lastname: Třeška
authors.forename: J
authors.initials: J
authors.lastname: Moláček
authors.forename: V
authors.initials: V
authors.lastname: Kuntscher
authors.forename: V
authors.initials: V
authors.lastname: Liška
authors.forename: Z
authors.initials: Z
authors.lastname: Slavík
mesh_terms: D000818:Animals; D002302:Cardiac Output / Q000502:physiology*; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006334:Heart Function Tests; D008297:Male; D023421:Models, Animal; D011651:Pulmonary Artery / Q000502:physiology*; D013552:Swine; D013815:Thermodilution; D014655:Vascular Resistance / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology; D016278:Ventricular Function, Right / Q000502:physiology