title: The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.
abstract: The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.
authors: Department of Chemistry, MSD, Newhouse, Lanarkshire ML1 5SH, UK. susannapier67@googlemail.com
authors: Susan
authors: S
authors: Napier
authors: Grant
authors: G
authors: Wishart
authors: William
authors: W
authors: Arbuckle
authors: James
authors: J
authors: Baker
authors: David
authors: D
authors: Barn
authors: Matilda
authors: M
authors: Bingham
authors: Angus
authors: A
authors: Brown
authors: Alan
authors: A
authors: Byford
authors: Chris
authors: C
authors: Claxton
authors: Mark
authors: M
authors: Craighead
authors: Kirsteen
authors: K
authors: Buchanan
authors: Lee
authors: L
authors: Fielding
authors: Lindsay
authors: L
authors: Gibson
authors: Richard
authors: R
authors: Goodwin
authors: Susan
authors: S
authors: Goutcher
authors: Nicholas
authors: N
authors: Irving
authors: Cliona
authors: C
authors: MacSweeney
authors: Rachel
authors: R
authors: Milne
authors: Chris
authors: C
authors: Mort
authors: Jeremy
authors: J
authors: Presland
authors: Hazel
authors: H
authors: Sloan
authors: Fiona
authors: F
authors: Thomson
authors: Zara
authors: Z
authors: Turnbull
authors: Trevor
authors: T
authors: Young
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D065092:Antidiuretic Hormone Receptor Antagonists; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D003500:Cyclization; D055808:Drug Discovery; D006801:Humans; D008099:Liver / Q000378:metabolism; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects
chemical_list: D000577:Amides; D065092:Antidiuretic Hormone Receptor Antagonists; D001372:Aza Compounds