title: Impact of obesity on airway and lung parenchyma remodeling in experimental chronic allergic asthma.
abstract: The impact of obesity on the inflammatory process has been described in asthma, however little is known about the influence of diet-induced obesity on lung remodeling. For this purpose, 56 recently weaned A/J mice were randomly divided into 2 groups. In the C group, mice were fed a standard chow diet, while OB animals received isocaloric high-fat diet to reach 1.5 of the mean body weight of C. After 12 weeks, each group was further randomized to be sensitized and challenged with ovalbumin (OVA) or saline. Twenty-four hours after the last challenge, collagen fiber content in airways and lung parenchyma, the volume proportion of smooth muscle-specific actin in alveolar ducts and terminal bronchiole, and the number of eosinophils in bronchoalveolar lavage fluid were higher in OB-OVA than C-OVA. In conclusion, diet-induced obesity enhanced lung remodeling resulting in higher airway responsiveness in the present experimental chronic allergic asthma.
authors: Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors: Simone A
authors: SA
authors: Saraiva
authors: Adriana L
authors: AL
authors: Silva
authors: Débora G
authors: DG
authors: Xisto
authors: Soraia C
authors: SC
authors: Abreu
authors: Johnatas D
authors: JD
authors: Silva
authors: Pedro L
authors: PL
authors: Silva
authors: Tatiana P F
authors: TP
authors: Teixeira
authors: Edwin R
authors: ER
authors: Parra
authors: Ana Laura N
authors: AL
authors: Carvalho
authors: Raquel
authors: R
authors: Annoni
authors: Thais
authors: T
authors: Mauad
authors: Vera L
authors: VL
authors: Capelozzi
authors: Patricia M R
authors: PM
authors: Silva
authors: Marco A
authors: MA
authors: Martins
authors: Patricia R M
authors: PR
authors: Rocco
mesh_terms: D000199:Actins / Q000032:analysis / Q000378:metabolism; D056151:Airway Remodeling / Q000502:physiology*; D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002908:Chronic Disease; D003094:Collagen / Q000032:analysis / Q000378:metabolism; D004195:Disease Models, Animal; D004804:Eosinophils / Q000166:cytology; D006967:Hypersensitivity / Q000209:etiology* / Q000473:pathology; D007150:Immunohistochemistry; D008168:Lung / Q000503:physiopathology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D046529:Microscopy, Electron, Transmission; D009765:Obesity / Q000150:complications* / Q000503:physiopathology*; D012123:Pulmonary Ventilation / Q000502:physiology
chemical_list: D000199:Actins; D003094:Collagen