title: Nesfatin-1 stimulates renal sympathetic nerve activity in rats.
abstract: Earlier examination reported that central injection of nesfatin-1 elevated blood pressure and suppressed food intake in conscious rats. In this study, we analyzed the effects of the intracerebroventricular injection of nesfatin-1 on the sympathetic nerve outflow to the kidney in urethane-anesthetized rats. An intracerebroventricular injection of nesfatin-1 significantly stimulated renal sympathetic nerve activity and blood pressure in a dose-dependent manner. Moreover, we examined the role of the melanocortin system on the sympathoexcitation caused by the nesfatin-1 injection. Pretreatment with the melanocortin-3/4 receptor antagonist, SHU9119, abolished the increase in nerve activity and blood pressure induced by nesfatin-1. Thus, the stimulating effects of nesfatin-1 administration on the sympathetic nerve activity of the kidney may depend on the central melanocortin system.
authors: Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan. mtanida@sk.ritsumei.ac.jp
authors: Mamoru
authors: M
authors: Tanida
authors: Masatomo
authors: M
authors: Mori
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D007276:Injections, Intraventricular; D007668:Kidney / Q000098:blood supply / Q000294:innervation*; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000502:physiology*; D000080866:Nucleobindins; D011333:Pro-Opiomelanocortin / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D044104:Receptor, Melanocortin, Type 3; D044101:Receptors, Melanocortin / Q000037:antagonists & inhibitors / Q000502:physiology; D012077:Renal Artery / Q000294:innervation / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects / Q000502:physiology; D017779:Sympathetic Fibers, Postganglionic / Q000187:drug effects / Q000502:physiology*
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C000630652:Nucb1 protein, rat; D000080866:Nucleobindins; D044104:Receptor, Melanocortin, Type 3; D044101:Receptors, Melanocortin; C514973:melanocortin 3 receptor, rat; C103272:SHU 9119; D011333:Pro-Opiomelanocortin; D009074:Melanocyte-Stimulating Hormones