title: Serum levels of chemokines in Parkinson's disease.
abstract: OBJECTIVE
  Neuroinflammatory processes seem to contribute to the degeneration of dopaminergic neurons in Parkinson's disease (PD). Chemokines play a role in the pathogenesis of inflammatory diseases, acting mainly as mediators of leukocyte recruitment to inflammatory sites. The aim of the present study was to compare the serum levels of chemokines between healthy subjects and PD patients and to correlate these levels with the severity of PD.
  
  
  METHODS
  We used ELISA to measure the levels of CCL3, CCL11, CCL24, CXCL8 and CXCL10 chemokines in the serum of PD patients (n = 47) and age- and gender-matched controls (n = 23). Patients were also clinically evaluated with the Unified Parkinson's Disease Rating Scale, the Modified Hoehn and Yahr Staging Scale and the Modified Schwab and England Activities of Daily Living Scale.
  
  
  RESULTS
  There was no significant difference in serum levels of chemokines between controls and PD patients. There was no correlation between the serum levels of chemokines and the clinical measures of disease severity.
  
  
  CONCLUSIONS
  These findings suggest that serum levels of chemokines may not be considered as potential biomarkers of PD.
authors: Neuroimmunology Group, Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors: Paula
authors: P
authors: Scalzo
authors: Aline Silva
authors: AS
authors: de Miranda
authors: Débora Cristina
authors: DC
authors: Guerra Amaral
authors: Márcia
authors: M
authors: de Carvalho Vilela
authors: Francisco
authors: F
authors: Cardoso
authors: Antonio Lúcio
authors: AL
authors: Teixeira
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D054413:Chemokine CCL11 / Q000097:blood*; D054423:Chemokine CCL24 / Q000097:blood*; D054405:Chemokine CCL3 / Q000097:blood*; D054357:Chemokine CXCL10 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000276:immunology
chemical_list: D015415:Biomarkers; D054413:Chemokine CCL11; D054423:Chemokine CCL24; D054405:Chemokine CCL3; D054357:Chemokine CXCL10; D016209:Interleukin-8