title: What is the role of the receptor for advanced glycation end products-ligand axis in liver injury?
abstract: Multiligand receptor for advanced glycation end products (RAGE) is expressed in a wide variety of tissues, including the liver. Interactions with its ligands lead to cellular activation and thus prolonged inflammation and apoptosis. RAGE also exists in a soluble, truncated isoform called soluble RAGE, which has the same ligand-binding specificity as membrane-RAGE; acting as decoy, it can contribute to the removal/neutralization of circulating ligands and the resultant reduction of signaling pathway activation. Experimental and clinical studies have highlighted the idea that the RAGE-ligand axis is involved in the development of liver fibrosis, inflammation, and regeneration after a massive injury and in the setting of liver transplantation. The involvement of the RAGE-ligand axis in vascular disease, diabetes, cancer, and neurodegeneration is well established, but it still needs to be clarified in the setting of liver diseases. We present a review of the recent literature on this receptor in surgical and clinical settings involving the liver, and we highlight the open issues and possible directions of future research.
authors: Institute of Clinical Physiology, National Research Council, Pisa, Italy. lapina@ifc.cnr.it
authors: Giuseppina
authors: G
authors: Basta
authors: Teresa
authors: T
authors: Navarra
authors: Paolo
authors: P
authors: De Simone
authors: Serena
authors: S
authors: Del Turco
authors: Amalia
authors: A
authors: Gastaldelli
authors: Franco
authors: F
authors: Filipponi
mesh_terms: D017127:Glycation End Products, Advanced / Q000378:metabolism; D024243:HMGB1 Protein / Q000502:physiology; D006801:Humans; D008024:Ligands; D008099:Liver / Q000378:metabolism / Q000503:physiopathology; D008107:Liver Diseases / Q000503:physiopathology*; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000502:physiology*
chemical_list: D017127:Glycation End Products, Advanced; D024243:HMGB1 Protein; D008024:Ligands; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic