title: [Molecular physiology of the endothelium and mechanisms of vascular permeability].
abstract: Endothelium of microvessels acts as selective barrier between blood and tissues and regulates transport of substances across vascular wall. In stressful situations permeability of microvessels increases acutely and leads to edema and the loss of organ function. This review describes molecular mechanisms of maintenance, loss and recovery of endothelial barrier as well as modern approaches to pharmacologic correction of vascular hyperpermeability.
authors: V P
authors: VP
authors: Shirinskiĭ
mesh_terms: D000818:Animals; D001692:Biological Transport; D002199:Capillary Permeability / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D008955:Models, Cardiovascular