title: Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry.
abstract: In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30%. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.
authors: Department of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.
authors: Chi-Hsiang
authors: CH
authors: Lien
authors: Wen-Shuo
authors: WS
authors: Kuo
authors: Keng-Chi
authors: KC
authors: Cho
authors: Chun-Yu
authors: CY
authors: Lin
authors: Yuan-Deng
authors: YD
authors: Su
authors: Lynn L H
authors: LL
authors: Huang
authors: Paul J
authors: PJ
authors: Campagnola
authors: Chen Yuan
authors: CY
authors: Dong
authors: Shean-Jen
authors: SJ
authors: Chen
mesh_terms: D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis*; D006046:Gold / Q000737:chemistry*; D008422:Materials Testing; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010777:Photochemistry / Q000379:methods; D012710:Serum Albumin, Bovine / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D020099:Coated Materials, Biocompatible; D012710:Serum Albumin, Bovine; D006046:Gold