title: A lipase-responsive vehicle using amphipathic polymer synthesized with the lipase as catalyst.
abstract: We describe an enzyme-responsive polymeric vehicle, which is of great interest in controlled drug delivery, biosensing, and other related areas. The polymer synthesized using lipase as catalyst in DMSO has a favorable molecular structure that is quickly hydrolyzed by lipase in aqueous phase, and allows a fast release of encapsulated molecules.
authors: Department of Chemical Engineering, The State Key Lab of Chemical Engineering, Tsinghua University, Beijing 100084, China.
authors: Jun
authors: J
authors: Ge
authors: Diannan
authors: D
authors: Lu
authors: Cheng
authors: C
authors: Yang
authors: Zheng
authors: Z
authors: Liu
mesh_terms: D002175:Candida / Q000187:drug effects; D002384:Catalysis; D016503:Drug Delivery Systems; D006801:Humans; D008049:Lipase / Q000008:administration & dosage / Q000737:chemistry*; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D011108:Polymers; D014867:Water; D011092:Polyethylene Glycols; D008049:Lipase