title: p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population.
abstract: BACKGROUND
  The common p53 codon 72 polymorphism has been investigated as a risk factor for cancer in different populations; however, the results have been inconsistent. This study investigated the risk of developing gastric or colorectal cancer associated with the p53 codon 72 polymorphism in a Korean population.
  
  
  METHODS
  We conducted a large-scale case-control study that included 2,213 gastric cancer patients; 1,829 colorectal cancer patients; and 1,700 healthy controls. Genotyping was performed with real-time polymerase chain reaction (PCR), using a TaqMan single-nucleotide polymorphism (SNP) genotyping assay.
  
  
  RESULTS
  The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of the p53 codon 72 polymorphism were 43.3, 42.0, and 13.0% in the gastric cancer patients; 40.5, 45.0, and 14.0% in the colorectal cancer patients; and 43.2, 45.6, and 11.2% in the controls, respectively. The Pro/Pro genotype was associated with an increased risk of gastric [age- and sex-adjusted odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.01-1.56, P = 0.04] and colorectal cancer (OR = 1.36, 95% CI = 1.07-1.72, P = 0.01). There were no significant interactions between the p53 codon 72 polymorphism and smoking or drinking.
  
  
  CONCLUSIONS
  Our results suggest that the Pro/Pro genotype is associated with modest increases in the risks of gastric cancer and colorectal cancer in a Korean population.
authors: Department of Preventive Medicine, Chonnam National University Medical School, 5, Hak 1-dong, Dong-gu, Gwangju, 501-746, South Korea.
authors: Hye-Rim
authors: HR
authors: Song
authors: Sun-Seog
authors: SS
authors: Kweon
authors: Hee Nam
authors: HN
authors: Kim
authors: Jin-Mei
authors: JM
authors: Piao
authors: Woo-Jun
authors: WJ
authors: Yun
authors: Jin-Su
authors: JS
authors: Choi
authors: Jun-Eul
authors: JE
authors: Hwang
authors: Ju-Young
authors: JY
authors: Yoon
authors: Hyeong-Rok
authors: HR
authors: Kim
authors: Young-Kyu
authors: YK
authors: Park
authors: Soo-Hyun
authors: SH
authors: Kim
authors: Yoo-Duk
authors: YD
authors: Choi
authors: Min-Ho
authors: MH
authors: Shin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003062:Codon / Q000235:genetics*; D003106:Colon / Q000378:metabolism / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D004247:DNA / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007414:Intestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011392:Proline / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D012007:Rectum / Q000378:metabolism / Q000473:pathology; D056910:Republic of Korea; D012307:Risk Factors; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D055815:Young Adult
chemical_list: D003062:Codon; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D004247:DNA; D011392:Proline