title: Development of a miniaturized HIFU device for glaucoma treatment with conformal coagulation of the ciliary bodies.
abstract: This study examined the feasibility of high-intensity focused ultrasound (HIFU) for glaucoma treatment with conformal coagulation of the ciliary bodies (CB). A miniaturized high frequency (21 MHz) device was developed, based on the geometry of the eye and adapted to the anatomy of the rabbit eyeball. Six line-focus lesions were distributed along a circle and produced by six cylindrical transducers. To be conformal, the numerical model predicted an intensity of 6.9 W/cm(2), with exposure duration of 3 s ON (powered per sector). In vivo experiments were conducted on two rabbits. A significant intraocular pressure reduction was noted (-45% and -31%). Histology demonstrated conformal and homogeneous coagulation of the CB without side effects.
authors: Inserm, U556, Université de Lyon, Lyon, France. thomas.charrel@inserm.fr
authors: Thomas
authors: T
authors: Charrel
authors: Florent
authors: F
authors: Aptel
authors: Alain
authors: A
authors: Birer
authors: Françoise
authors: F
authors: Chavrier
authors: Fabrice
authors: F
authors: Romano
authors: Jean-Yves
authors: JY
authors: Chapelon
authors: Philippe
authors: P
authors: Denis
authors: Cyril
authors: C
authors: Lafon
mesh_terms: D000818:Animals; D002924:Ciliary Body / Q000000981:diagnostic imaging*; D003198:Computer Simulation; D004195:Disease Models, Animal; D005901:Glaucoma / Q000000981:diagnostic imaging* / Q000628:therapy*; D008904:Miniaturization / Q000379:methods; D011817:Rabbits; D014464:Ultrasonic Therapy / Q000295:instrumentation*; D014463:Ultrasonography