title: Biological effects of space radiation on human cells: history, advances and outcomes.
abstract: Exposure to radiation is one of the main concerns for space exploration by humans. By focusing deliberately on the works performed on human cells, we endeavored to review, decade by decade, the technological developments and conceptual advances of space radiation biology. Despite considerable efforts, the cancer and the toxicity risks remain to be quantified: 1) the nature and the frequency of secondary heavy ions need to be better characterized in order to estimate their contribution to the dose and to the final biological response; 2) the diversity of radiation history of each astronaut and the impact of individual susceptibility make very difficult any epidemiological analysis for estimating hazards specifically due to space radiation exposure. 3) Cytogenetic data undoubtedly revealed that space radiation exposure produce significant damage in cells. However, our knowledge of the basic mechanisms specific to low-dose, to repeated doses and to adaptive response is still poor. The application of new radiobiological techniques, like immunofluorescence, and the use of human tissue models different from blood, like skin fibroblasts, may help in clarifying all the above items.
authors: Institut National de la Santé et de la Recherche Médicale, U836, Groupe de Radiobiologie, Paris, France.
authors: Mira
authors: M
authors: Maalouf
authors: Marco
authors: M
authors: Durante
authors: Nicolas
authors: N
authors: Foray
mesh_terms: D018480:Astronauts; D003359:Cosmic Radiation; D003582:Cytogenetics; D004249:DNA Damage; D005347:Fibroblasts / Q000528:radiation effects; D020450:Heavy Ions; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008856:Microscopy, Fluorescence / Q000379:methods; D011829:Radiation Dosage; D011853:Radiobiology / Q000266:history*; D012062:Relative Biological Effectiveness; D013026:Space Flight / Q000266:history*