title: Tooth movement into distraction regenerate: when should we start?
abstract: BACKGROUND
  The aim of this study was to evaluate clinically, radiographically, and histologically orthodontic tooth movement into bone regenerate after mandibular distraction osteogenesis to elucidate the optimal timing for initiating tooth movement.
  
  
  METHODS
  The study sample consisted of 9 male mongrel dogs. An average edentulous space of 9 mm was created by using a custom-made bone-borne distractor fixed on the mandibular corpus of each dog. The dogs were equally divided into 3 groups, and tooth movement began into the distraction gap after 1, 3, or 6 weeks of consolidation. The rate and type of tooth movement as well as the adverse tissue reactions (root resorption and crestal bone loss) were evaluated.
  
  
  RESULTS
  Radiographic and histologic analyses showed analogous adverse tissue reactions in association with early tooth movement into the regenerate bone. Furthermore, the rate and type of tooth movement were variable in the 3 groups.
  
  
  CONCLUSIONS
  Early tooth movement into the distraction regenerate is not recommended because it could result in adverse tissue reactions. Moreover, radiographic examination of the distraction regenerate is advisable and could be used as a guide before starting tooth movement.
authors: Orthodontic Department, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt.
authors: Fouad Aly
authors: FA
authors: El Sharaby
authors: Nader Nabil
authors: NN
authors: El Bokle
authors: Dalia Mohamed
authors: DM
authors: El Boghdadi
authors: Yehya Ahmed
authors: YA
authors: Mostafa
mesh_terms: D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000209:etiology; D000818:Animals; D001641:Bicuspid / Q000473:pathology; D015519:Bone Density / Q000502:physiology; D001860:Bone Plates; D001861:Bone Regeneration / Q000502:physiology*; D001863:Bone Screws; D002113:Calcification, Physiologic / Q000502:physiology; D003739:Dental Cementum / Q000473:pathology; D003804:Dentin / Q000473:pathology; D004285:Dogs; D004867:Equipment Design; D016267:External Fixators; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D009967:Orthodontic Appliances; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D019857:Osteogenesis, Distraction / Q000295:instrumentation / Q000379:methods*; D010027:Osteotomy / Q000379:methods; D010513:Periodontal Ligament / Q000473:pathology; D016300:Radiography, Bitewing; D012391:Root Resorption / Q000000981:diagnostic imaging / Q000209:etiology; D013997:Time Factors; D014087:Tooth Movement Techniques / Q000379:methods*