title: Outcome at 4.5 years of children born after expectant management of early-onset hypertensive disorders of pregnancy.
abstract: OBJECTIVE
  The objective of the study was to describe neurodevelopmental outcome at the age of 4.5 years in 216 children, born after expectant management of severe early-onset hypertensive complications of pregnancy.
  
  
  METHODS
  This was a prospective follow-up study until age 4.5 years from maternal admission onward. Developmental outcome measurements included child intelligence quotient and behavioral, motor, and neurological outcome. Abnormal composite outcome (perinatal mortality or abnormal developmental outcome) was studied in relation to gestational age (GA), birthweight (BW), and perinatal variables.
  
  
  RESULTS
  Fetal and neonatal mortality was 9% and 8%, respectively. Of the 178 survivors, 149 (84%) were seen for follow-up. Mean GA was 31.4 weeks and 90% were born growth restricted. Abnormal developmental outcome occurred in 20% and abnormal composite outcome in 37%.
  
  
  CONCLUSIONS
  Perinatal mortality or abnormal child development occurs in one third of pregnancies with early-onset and severe hypertensive complications and is highest in the lowest GA and BW ranges.
authors: Department of Neonatology, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands. a.vanwassenaer@amc.uva.nl
authors: Aleid G
authors: AG
authors: van Wassenaer
authors: Jolanda
authors: J
authors: Westera
authors: Petra E M
authors: PE
authors: van Schie
authors: Bregje A
authors: BA
authors: Houtzager
authors: Anneke
authors: A
authors: Cranendonk
authors: Laila
authors: L
authors: de Groot
authors: Wessel
authors: W
authors: Ganzevoort
authors: Hans
authors: H
authors: Wolf
authors: Johanna I P
authors: JI
authors: de Vries
mesh_terms: D002657:Child Development; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology; D008297:Male; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000628:therapy*; D011446:Prospective Studies; D013997:Time Factors