title: Highly convergent total synthesis of (+)-lithospermic acid via a late-stage intermolecular C-H olefination.
abstract: The total synthesis of (+)-lithospermic acid is reported, which exploits two successive C-H activation reactions as key steps. Rh-catalyzed carbene C-H insertion reaction utilizing Davies's catalyst was used to forge dihydrobenzofuran core, and a late-stage intermolecular C-H olefination coupled the olefin unit with the dihydrobenzofuran core to construct the molecule in a highly convergent manner.
authors: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Dong-Hui
authors: DH
authors: Wang
authors: Jin-Quan
authors: JQ
authors: Yu
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D053630:Depsides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D001572:Benzofurans; D053630:Depsides; C046833:lithospermic acid