title: Improved Fmoc synthesis of bradykinin.
abstract: Two arginine side-chain protecting groups, N(G)-4-methoxy-2,3,6-trimethylbenzensulfonyl group (Mtr) and N(G)-2,2,5,7,8-pentamethylchroman-6-sulfonyl (Pmc), have been investigated at both the Arg(1) and/or Arg(9) position of the bioactive peptide, Bradykinin using Fluorenylmethyloxycarbonyl (Fmoc) Solid Phase Peptide Synthesis. A more efficient synthesis of the peptide has been found when a combination of Arg(Mtr) is present at position 1 and Arg(Pmc) is present at position 9 giving a cleaved pure yield of 52%.
authors: IFS, Massey University, Palmerston North, New Zealand.
authors: Rachel J
authors: RJ
authors: Stephenson
authors: Paul G
authors: PG
authors: Plieger
authors: David R K
authors: DR
authors: Harding
mesh_terms: D001920:Bradykinin / Q000138:chemical synthesis*; D005449:Fluorenes / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*; D014665:Vasodilator Agents / Q000138:chemical synthesis*
chemical_list: D005449:Fluorenes; D014665:Vasodilator Agents; D001920:Bradykinin