title: Brain natriuretic peptide and acute hypobaric hypoxia in humans.
abstract: In animal models, the secretion of the cardiac hormone, brain natriuretic peptide (BNP), and its closely related peptide, atrial natriuretic peptide (ANP), are stimulated by acute hypoxia. There is extensive human evidence for a rise in ANP under acute hypoxic conditions but very little evidence regarding the BNP response to acute hypoxia in humans. We therefore subjected seven healthy subjects to an acute hypobaric hypoxic stimulus to examine if BNP secretion increases rapidly. Significant hypoxaemia (mean nadir oxygen saturation 62.3%) was induced but no significant rise in BNP occurred. This suggests that either such acute hypoxaemia is well tolerated by the healthy human heart or it is not a stimulus for BNP secretion.
authors: Newcastle and Northumbria NHS Trust, Tyne and Wear, UK. DoctorDRWoods@aol.com
authors: David
authors: D
authors: Woods
authors: Tim
authors: T
authors: Hooper
authors: Adrian
authors: A
authors: Mellor
authors: Pete
authors: P
authors: Hodkinson
authors: Rob
authors: R
authors: Wakeford
authors: Bob
authors: B
authors: Peaston
authors: Steve
authors: S
authors: Ball
authors: Nic
authors: N
authors: Green
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism; D015444:Exercise / Q000502:physiology; D006321:Heart / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D020097:Natriuretic Peptide, Brain / Q000097:blood / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism
chemical_list: D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D010100:Oxygen