title: [Study of efficacy of anaferon pediatric in mice infected by pandemic influenza virus A(H1N1/09)v].
abstract: OBJECTIVE
  To study efficacy of anaferon pediatric in mice infected by pandemic influenza virus A(H1N1/09)v.
  
  
  METHODS
  Influenza virus strain A/California/07/2009 (H1N1)v was used. Three groups of BALB/c mice intranasally inoculated with influenza virus were studied. First group received solution of Anaferon pediatric during 5 days before and 8 days after inoculation, 2nd group received Tamiflu during 5 days after inoculation. Distilled water was administered orally to mice from control group.
  
  
  RESULTS
  It was shown that Anaferon pediatric used as preventive and treatment agent in mice intranasally inoculated with 100% infectious dose of influenza virus strain A/ California/07/2009 (H1N1)v had antiviral effect, which expressed in 10-fold decreased reproduction of influenza virus in lungs of infected mice compared to control group measured 4, 6, and 8 days after inoculation.
  
  
  CONCLUSIONS
  Use of anaferon pediatric before and after inoculation with influenza virus A(H1N1/09)v was not less effective than use of Tamiflu after inoculation.
authors: L I
authors: LI
authors: Shishkina
authors: M O
authors: MO
authors: Skarnovich
authors: A S
authors: AS
authors: Kabanov
authors: A A
authors: AA
authors: Sergeev
authors: S A
authors: SA
authors: Tarasov
authors: S A
authors: SA
authors: Sergeeva
authors: Épshteĭn
authors: E M
authors: EM
authors: Malkova
authors: E A
authors: EA
authors: Stavskiĭ
authors: I G
authors: IG
authors: Drozdov
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000453:epidemiology; D053139:Oseltamivir / Q000494:pharmacology*; D058873:Pandemics; D013997:Time Factors
chemical_list: D000906:Antibodies; D000998:Antiviral Agents; C547732:anaferon; D053139:Oseltamivir