title: Use of a collagen-elastin matrix for hard to treat soft tissue defects.
abstract: As deep soft tissue defects with exposed bone, cartilage or tendons are not suitable for wound closure with skin mesh grafts, other techniques are needed. We report on six patients, one female and five males, aged between 32 and 89 years, and deep soft tissue defects with exposed tendons, cartilage or bone. The aetiology of these defects was vascular (n = 3), tumour surgery (2), and post-traumatic (1). Wounds were treated with a collagen-elastin matrix applied above the exposed structures. In five patients, the procedure was combined with mesh graft transplantation in the same setting. Follow-up varied between 12 and 40 weeks. Wound healing was uncomplicated in all transplanted patients until first dressing change after 7 days. All but one transplant showed a 100% take rate and the transplant was stable within 10-14 days. A complete wound closure was also achieved without transplantation, but this took 8 weeks. No adverse effects were noted. There was no skin contracture of the skin grafts. Collagen-elastin matrix with split-thickness skin grafts is a useful tool in deep soft tissue. The time to heal can be reduced.
authors: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, Dresden, Germany. wollina-uw@khdf.de
authors: Uwe
authors: U
authors: Wollina
authors: Antje
authors: A
authors: Meseg
authors: Andreas
authors: A
authors: Weber
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials; D004549:Elastin / Q000494:pharmacology; D005109:Extracellular Matrix; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007871:Leg Ulcer / Q000150:complications / Q000601:surgery; D008297:Male; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000150:complications / Q000601:surgery; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial; D017695:Soft Tissue Injuries / Q000209:etiology / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D004549:Elastin