title: Anti diabetic effect of Achyranthes rubrofusca leaf extracts on alloxan induced diabetic rats.
abstract: The aqueous and ethanolic extracts of Achyranthes rubrofuca leaves (AR) were studied for their hypoglycemic activity. Thirty animals were taken and they were divided into five groups. First group acts as control, remaining 4 groups were induced diabetics by administering alloxan (120 mg/kg i.p). Second group serves as diabetes control, third group treated with Glibenclamide (5 mg/kg), fourth and fifth group were given aqueous and ethanolic extracts of leaves (200 mg/kg/body weight/day/po for 28 days) to rats. The anti hyperglycemic activity by AR was compared with the group treated with the standard oral hypoglycemic agent. Treatment with aqueous and ethanolic extract of AR caused a significant change when compared to the untreated animals with respect to body weight, blood glucose level, and lipid profile. Aqueous extract showed slightly better activity than ethanolic extract but it may not be statistically significant. There is significant increases in the pancreatic enzyme like SOD, CAT and Glutathione expression when compare with the untreated group. Decreases in LPO level is observed in the group treated with extracts when compare with control groups animals. The histopathological studies also show the regenerative effect of pancreas, supported the above activities of AR leaves.
authors: Department of Pharmaceutical Chemistry, PSG College of Pharmacy, Coimbatore, Tamilnadu, India. ggeetha97@rediffmail.com
authors: Govindarajulu
authors: G
authors: Geetha
authors: Prasanth
authors: P
authors: Kalavalarasariel Gopinathapillai
authors: Veindramuthu
authors: V
authors: Sankar
mesh_terms: D029044:Achyranthes; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008055:Lipids; D010936:Plant Extracts; D000496:Alloxan