title: Syncope and seizures following human papillomavirus vaccination: a retrospective case series.
abstract: OBJECTIVE
  To quantify and characterise the reports of syncope and seizures following quadrivalent (4v) human papillomavirus (HPV) vaccination.
  
  
  METHODS
  Retrospective case series of notifications to SAEFVIC (Surveillance of Adverse Events Following Vaccination In the Community), May 2007 - April 2009.
  
  
  METHODS
  Incidence of syncope and seizure following 4vHPV vaccination; clinical outcomes.
  
  
  RESULTS
  97/1653 SAEFVIC reports met the study criteria: afebrile seizures (3), syncopal seizures (31) and syncope alone (63). Median age at vaccination was 15 years (range, 8-26 years). Injuries were reported in seven cases, including one vertebral fracture. A SAEFVIC clinic review was undertaken in 41% (40/97) and 22 patients received further 4vHPV vaccine doses administered supine, with no recurrences. The reporting rate after 4vHPV vaccine for syncope and syncopal seizures was 7.8/100, 000 and 2.6/100, 000 doses distributed, respectively.
  
  
  CONCLUSIONS
  Syncope and syncopal seizures occurred after 4vHPV vaccination in Victoria at rates similar to those seen internationally. Clinical review allowed clarification of the diagnosis and management, including safe administration of further doses under supervision.
authors: Murdoch Childrens Research Institute, Melbourne, VIC, Australia. nigel.crawford@rch.org.au
authors: Nigel W
authors: NW
authors: Crawford
authors: Hazel J
authors: HJ
authors: Clothier
authors: Sonja
authors: S
authors: Elia
authors: Teresa
authors: T
authors: Lazzaro
authors: Jenny
authors: J
authors: Royle
authors: Jim P
authors: JP
authors: Buttery
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D002648:Child; D005260:Female; D006801:Humans; D053918:Papillomavirus Vaccines / Q000009:adverse effects*; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology*; D013575:Syncope / Q000209:etiology*; D055815:Young Adult
chemical_list: D053918:Papillomavirus Vaccines