title: A study of comparison between the nationwide epidemiological survey in 1991 and previous surveys on behçet's disease in Japan.
abstract: The 4th nationwide epidemiological survey on Behçet disease (BD), which included all patients with BD at 1,200 hospitals selected at random from 10,081 hospitals in Japan, was carried out by the BD Research Committee of the Ministry of Health and Welfare in 1991 to examine the epidemiological features of BD in Japan by comparing with previous surveys. 3,938 patients from these hospitals were examined by the Japanese diagnostic criteria of BD (JCBD) revised in 1987 and the International criteria for classification of BD (ICBD). Among these 3,938 patients, 622 patients were only suspected of having BD or clinical signs of the disease were unknown, and most of these patients were incompatible with the ICBD. So these patients were excluded from the study of epidemiological features. The average patients age has risen 7-8 years over the last 20 years and the average age of onset in both sexes increased by about 3 years from 1972 to 1991. While a decrease in the sex ratio was seen in the complete-type and the incomplete-type BD without ocular symptoms, a sustained high sex ratio was shown in incomplete-type BD with ocular symptoms. The positive rate of HLA-B51 antigen was 54.9% (men: 56.9%, women: 52.2%) significantly higher than die 15-16% in healthy subjects but it might have been gradually decreasing. Also the clinical course of BD has become too mild for prognosis. According to diese epidemiological features of BD, the clinical manifestation of BD in Japan might have become the Western type of BD.
authors: Department of Public Health, Dokkyo Univ. School of Medicine, 321-0293, Mibu, Tochigi, Japan, m-nishi@dokkyomed.ac.jp.
authors: M
authors: M
authors: Nishiyama
authors: K
authors: K
authors: Nakae
authors: S
authors: S
authors: Yukawa
authors: T
authors: T
authors: Hashimoto
authors: G
authors: G
authors: Inaba
authors: M
authors: M
authors: Mochizuki
authors: T
authors: T
authors: Sakane