title: Use of band cell percentage as an early predictor of death and ICU admission in severe acute pancreatitis.
abstract: OBJECTIVE
  Severe acute pancreatitis has a high mortality rate, with over half of the deaths occurring from multiorgan failure in the first seven days of hospitalization. Recruitment of neutrophils to the inflammation in the pancreas is the early event that can escalate to the systemic inflammatory response that causes multiorgan failure. We undertook a retrospective chart review study to ask whether the percentage of immature neutrophils (band cells) in plasma could be used as an early predictor of adverse outcomes (ICU admissions and deaths).
  
  
  METHODS
  Age, gender, etiology, albumin, glucose, AST, ALT, y-glutamyltransferase, Ranson score, and band cell percentage were collected from the charts of 169 patients with documented severe acute pancreatitis. Odds, ratios and ROC curves for ICU admissions and deaths were obtained, and sensitivity and specificity for these outcomes was calculated.
  
  
  RESULTS
  Two parameters, band cell percentage and Ranson score, were statistically associated with adverse effects. At their optimal cut-off values, calculated from the ROC curves, they did not differ significantly from each other in their sensitivity and specificity for predicting either death or ICU admission.
  
  
  CONCLUSIONS
  Band cell percentage might be used clinically as a simple early predictor of adverse outcome in severe acute pancreatitis.
authors: Department of Chinese Medicine and Integrated Western Medicine, West China Hospital, Chengdu, China.
authors: Lin
authors: L
authors: Zhu
authors: Guangyuan
authors: G
authors: Chen
authors: Qing
authors: Q
authors: Xia
authors: Wenfu
authors: W
authors: Tang
authors: Zhongwen
authors: Z
authors: Huang
authors: Meihua
authors: M
authors: Wang
authors: Jia
authors: J
authors: Guo
authors: Xiaolan
authors: X
authors: Yang
authors: Yan
authors: Y
authors: Zhou
mesh_terms: D000208:Acute Disease; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010195:Pancreatitis / Q000401:mortality*; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies