title: Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye.
abstract: We previously proposed a new strategy to replace a vitreous body with a novel foldable capsular vitreous body (FCVB). In this study, the FCVB was designed to mimic natural vitreous morphology, and evaluate its physiological functions compared with traditional silicone oil substitutes, in an established rabbit model of proliferative vitreoretinopathy. We found that FCVB was a very good replacement for closely mimicking the morphology and restoring the physiological functions, such as the support, refraction, and cellular barriers, of the rabbit vitreous body. The study has provided us with a novel research and therapy strategy that could effectively mimic the morphology and physiological function of the rabbit vitreous body.
authors: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
authors: Jiajia
authors: J
authors: Chen
authors: Qianying
authors: Q
authors: Gao
authors: Yaqin
authors: Y
authors: Liu
authors: Jian
authors: J
authors: Ge
authors: Xianwu
authors: X
authors: Cao
authors: Yan
authors: Y
authors: Luo
authors: Danping
authors: D
authors: Huang
authors: Gege
authors: G
authors: Zhou
authors: Shaofen
authors: S
authors: Lin
authors: Jianxian
authors: J
authors: Lin
authors: Chi Ho
authors: CH
authors: To
authors: Andrew W
authors: AW
authors: Siu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D032701:Biomimetics; D005260:Female; D006801:Humans; D020007:Implants, Experimental; D008297:Male; D011817:Rabbits; D012827:Silicone Oils / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D018630:Vitreoretinopathy, Proliferative / Q000503:physiopathology / Q000601:surgery; D014822:Vitreous Body / Q000033:anatomy & histology / Q000737:chemistry* / Q000378:metabolism* / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D012827:Silicone Oils