title: [Antioxidant enzymes and lipid peroxidation products in patients with pulmonary tuberculosis].
abstract: BACKGROUND
  A lot of studies have dealt with the oxidative stress in pulmonary diseases, and some of them with tuberculosis as well. The aim of this study was to examine the antioxidant enzyme level (superoxide dismutase, glutathione peroxidase, catalase) and the lipid peroxidation products in patients with tuberculosis.
  
  
  METHODS
  Forty patients with tuberculosis were included in the study. The examined parameters were measured before and three weeks after the beginning of the antituberculosis treatment (group I). The control group included 40 healthy persons (group II).
  
  
  RESULTS
  The superoxide dismutase level was significantly lower in group I in both measurements (p < 0.001 and p < 0.01) in relation to group II, but there were no significant changes in its level during the therapy. During the treatment, the glutation peroxidase level significantly increased (p < 0.05), and in relation to group II, its level was significantly lower in both measurements in group I (p < 0.001 and p < 0.001). The catalase level significantly increased during the treatment, but there was no significant difference in relation to group II level. There was no significant difference in relation to the lipid peroxidase products between the groups.
  
  
  CONCLUSIONS
  Our study group had reduced antioxidant enzyme level and some of them showed significant improvement during the treatment. The lipid peroxidase product level was stable.
  
  
  CONCLUSIONS
  In patients with tuberculosis the antioxidative status is lower and its level and possible development of the oxidative stress depend on the disease severity.
authors: Klinika za plućne bolesti i tuberkulozu, Klinicki centar Nis, Nis.
authors: Slavica
authors: S
authors: Golubović
authors: Ivana
authors: I
authors: Stanković
authors: Lidija
authors: L
authors: Ristić
authors: Vladan
authors: V
authors: Cosić
authors: Ivanka
authors: I
authors: Dordević
authors: Milan
authors: M
authors: Radović
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D002374:Catalase / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase