title: Novel autoantibodies and clinical phenotypes in adult and juvenile myositis.
abstract: Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the clinical associations of the myositis-specific autoantibodies, with particular attention to the recently identified and characterized novel myositis autoantibodies: p155/140, p140 (MJ), CADM-140 (MDA5), SAE, and 200/100.
authors: Royal National Hospital for Rheumatic Diseases, NHS Foundation Trust, Upper Borough Walls, Bath, Somerset, BA1 1RL, UK. prpzeb@bath.ac.uk
authors: Zoe E
authors: ZE
authors: Betteridge
authors: Harsha
authors: H
authors: Gunawardena
authors: Neil J
authors: NJ
authors: McHugh
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D002648:Child; D006801:Humans; D009220:Myositis / Q000276:immunology*; D010641:Phenotype
chemical_list: D001323:Autoantibodies; D001324:Autoantigens