title: Serum uric acid levels correlate with filling pressures in systolic heart failure.
abstract: The authors studied the relationship between liver function tests and serum uric acid level with clinical and hemodynamic profiles in heart failure. Fifty patients (aged 44±15 years; 74.5% men) with an ejection fraction (EF) <35% were enrolled and clinical assessment was performed. Hemodynamic indices (including pulmonary arterial pressure [PAP], pulmonary capillary wedge pressure [PCWP], and cardiac index were studied by standard Edwards Lifesciences Swan-Ganz catheters, and liver function tests and serum uric acid level were measured simultaneously. Fifty age- and sex-matched controls with normal EF were also studied. A total of 73% of patients had ischemic cardiomyopathy. Mean uric acid level was 7.2±3.8 mg/dL and was significantly higher than in the control group (P value<.001). In multivariate analysis, uric acid correlated significantly with PAP (r=.5, P<.001) and PCWP (r=.4, P=.002) and was also associated with clinical signs of rales, edema, paroxysmal nocturnal dyspnea (r=.5, P=.01), and New York Heart Association class (r=.4, P=.005). Uric acid level was also correlated inversely with left ventricular EF (r=.27, P=.006). Elevated uric acid levels in patients with systolic heart failure is associated with impaired clinical and hemodynamic profile and might be used as a noninvasive indicator of elevated left ventricular filling pressures.
authors: Rajaee Cardiovascular, Medical & Research Center, Heart Failure & Transplantation, Tehran, Iran.
authors: Ahmad
authors: A
authors: Amin
authors: Farveh
authors: F
authors: Vakilian
authors: Majid
authors: M
authors: Maleki
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization; D005260:Female; D054143:Heart Failure, Systolic / Q000097:blood* / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008111:Liver Function Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*; D016277:Ventricular Function, Left; D017725:Ventricular Pressure
chemical_list: D014527:Uric Acid