title: Adenoid cystic carcinoma of the prostate: case report on a rare entity and review of the literature.
abstract: Adenoid cystic carcinoma is an unusual histological variant of prostatic carcinoma. Because of its rarity, the natural history of this tumor is not known. Here we report this rare entity in a 62-year-old man who presented with symptoms of urinary tract obstruction. Digital rectal examination and ultrasonography (USG) showed an enlarged hard nodular prostate. Serum prostate-specific antigen (PSA) and prostatic acid phosphate levels were found to be within the normal range. Transrectal ultrasound-guided 12 core biopsies of prostate showed morphological features of an adenoid cystic carcinoma in 8 cores (bilateral, mid and base) on histopathological examination. Immunohistochemistry performed for PSA on paraffin section was negative. After diagnosis, bilateral orchidectomy was performed, and hormonal therapy was started in the form of androgen receptor blocker. The patient was clinically stable during a limited follow up of six months.
authors: Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors: Arvind
authors: A
authors: Ahuja
authors: Prasenjit
authors: P
authors: Das
authors: Narender
authors: N
authors: Kumar
authors: Ashish Kumar
authors: AK
authors: Saini
authors: Amlesh
authors: A
authors: Seth
authors: Ruma
authors: R
authors: Ray
mesh_terms: D000135:Acid Phosphatase; D000726:Androgen Antagonists / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D003528:Carcinoma, Adenoid Cystic / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D051517:Digital Rectal Examination; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D017027:Protein Tyrosine Phosphatases / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists; D015415:Biomarkers; D000135:Acid Phosphatase; C428439:prostatic acid phosphatase; D017027:Protein Tyrosine Phosphatases; D017430:Prostate-Specific Antigen