title: Chlamydia trachomatis and placental inflammation in early preterm delivery.
abstract: Chlamydia trachomatis may infect the placenta and subsequently lead to preterm delivery. Our aim was to evaluate the relationship between the presence of Chlamydia trachomatis and signs of placental inflammation in women who delivered at 32 weeks gestation or less.
  
  
  METHODS
  placental histology and clinical data were prospectively obtained from 304 women and newborns at the Erasmus MC-Sophia, Rotterdam, the Netherlands. C. trachomatis testing of placentas was done retrospectively using PCR. C. trachomatis was detected in 76 (25%) placentas. Histological evidence of placental inflammation was present in 123 (40%) placentas: in 41/76 (54%) placentas with C. trachomatis versus 82/228 (36%) placentas without C. trachomatis infection (OR 2.1, 95% CI 1.2-3.5). C. trachomatis infection correlated with the progression (P = 0.009) and intensity (P = 0.007) of materno-fetal placental inflammation. C. trachomatis DNA was frequently detected in the placenta of women with early preterm delivery, and was associated with histopathological signs of placental inflammation.
authors: Department of Paediatric Infectious Disease and Immunology, Erasmus MC, Rotterdam, The Netherlands. Rours@mac.com
authors: G Ingrid J G
authors: GI
authors: Rours
authors: Ronald R
authors: RR
authors: de Krijger
authors: Alewijn
authors: A
authors: Ott
authors: Hendrina F M
authors: HF
authors: Willemse
authors: Ronald
authors: R
authors: de Groot
authors: Luc J I
authors: LJ
authors: Zimmermann
authors: Renee F
authors: RF
authors: Kornelisse
authors: Henri A
authors: HA
authors: Verbrugh
authors: Roel P
authors: RP
authors: Verkooijen
mesh_terms: D000328:Adult; D002690:Chlamydia Infections / Q000453:epidemiology / Q000382:microbiology*; D002692:Chlamydia trachomatis / Q000235:genetics / Q000302:isolation & purification*; D002821:Chorioamnionitis / Q000453:epidemiology / Q000382:microbiology*; D015331:Cohort Studies; D017931:DNA Primers / Q000737:chemistry; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000453:epidemiology / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D047928:Premature Birth / Q000209:etiology*; D015995:Prevalence; D011446:Prospective Studies; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D004269:DNA, Bacterial