title: Clinical presentations of food allergy.
abstract: Food allergies are immune-mediated responses to food proteins. Because of differences in the underlying immunologic mechanisms, there are varying clinical presentations of food allergy. This article discusses the manifestations of IgE-mediated disorders, including urticaria and angioedema, rhinoconjunctivitis, asthma, gastrointestinal anaphylaxis, generalized anaphylaxis, food-dependent exercise-induced anaphylaxis, and oral allergy syndrome. It also reviews the presentations of mixed IgE- and cell-mediated disorders, including atopic dermatitis and eosinophilic gastrointestinal disorders. Finally, the manifestations of cell-mediated food allergies are discussed, including dietary protein-induced proctitis and proctocolitis, food protein-induced enterocolitis syndrome, celiac disease, and food-induced pulmonary hemosiderosis.
authors: Division of Allergy and Immunology, Center for Cancer and Blood Disorders, Children's National Medical Center, 111 Michigan Avenue, North West, Washington, DC 20010, USA.
authors: Darlene K
authors: DK
authors: Mansoor
authors: Hemant P
authors: HP
authors: Sharma
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D004044:Dietary Proteins / Q000276:immunology; D005512:Food Hypersensitivity / Q000145:classification* / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology; D018928:Immunity, Mucosal / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology*
chemical_list: D004044:Dietary Proteins; D007073:Immunoglobulin E