title: Esophageal carcinosarcoma presenting as a fever with elevated serum interleukin-6.
abstract: We report a patient with esophageal carcinosarcoma who initially presented with fever. A 57-year-old man with a 4-month history of intermittent fever was referred to our hospital and diagnosed as having esophageal carcinosarcoma. High fever persisted and serum concentration of interleukin-6 was markedly elevated. In contrast, after thoracic esophagectomy, the fever subsided and interleukin-6 serum levels rapidly normalized. The clinical course of the patient suggests that the tumor produced interleukin-6 and this was associated not only with inflammation, but also the aggressive biologic behavior of the tumor.
authors: Department of Surgical Oncology, Hokkaido University School of Medicine, Sapporo, Japan. s-hayama@par.odn.ne.jp
authors: Satoshi
authors: S
authors: Hayama
authors: Shunichi
authors: S
authors: Okushiba
authors: Toshiaki
authors: T
authors: Shichinohe
authors: Satoshi
authors: S
authors: Hirano
authors: Eiichi
authors: E
authors: Tanaka
authors: Satoshi
authors: S
authors: Kondo
mesh_terms: D002296:Carcinosarcoma / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D004938:Esophageal Neoplasms / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D005334:Fever / Q000209:etiology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D015850:Interleukin-6