title: Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-D-aspartate receptor antibodies.
abstract: Paraneoplastic limbic encephalitis associated with ovarian teratoma has recently been related to the development of antibodies to specific heteromers of the N-methyl-d-aspartate receptor and exhibits various manifestations including psychiatric symptoms, hypoventilation, seizures and derangement of autonomic nervous system function. Although recovery can sometimes occur spontaneously, early tumour resection with immunotherapy facilitates earlier recovery. Herein, we describe anaesthetic management of a 20-year-old woman who developed general convulsions and decreased level of consciousness, whom we suspected of having paraneoplastic limbic encephalitis and was scheduled for left ovarian tumour resection. Anaesthetic management was successful with no complications but the case acts as focus of discussion for the potential interaction of N-methyl-D-aspartate receptors and anaesthetic sensitivity.
authors: Department of Anesthesiology and Clinical Research, National Hospital Organization Zentsuji Hospital, Zentsuji, Japan. hirkawa@jun.ncvc.go.jp
authors: H
authors: H
authors: Kawano
authors: E
authors: E
authors: Hamaguchi
authors: S
authors: S
authors: Kawahito
authors: Y M
authors: YM
authors: Tsutsumi
authors: K
authors: K
authors: Tanaka
authors: H
authors: H
authors: Kitahata
authors: S
authors: S
authors: Oshita
mesh_terms: D000768:Anesthesia, General / Q000379:methods*; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D006801:Humans; D020363:Limbic Encephalitis / Q000209:etiology* / Q000276:immunology; D010051:Ovarian Neoplasms / Q000150:complications / Q000601:surgery*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D012640:Seizures / Q000209:etiology; D013724:Teratoma / Q000150:complications / Q000601:surgery*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate