title: High b-value q-space analyzed diffusion-weighted MRI using 1.5 tesla clinical scanner; determination of displacement parameters in the brains of normal versus multiple sclerosis and low-grade glioma subjects.
abstract: OBJECTIVE
  We aimed to determine the displacement parameters in the brains of normal individuals relative to brain parenchymal abnormalities, such as multiple sclerosis (MS) and low-grade glioma, by q-space imaging (QSI) using 1.5-T magnetic resonance (MR) scanner.
  
  
  METHODS
  Thirty-five normal, three pathologically proven low-grade glioma, and five MS subjects were imaged by a 1.5-T MR unit for QSI (b-values, 0-12,000 s/mm(2)). Mean displacement (MD) values in white matter (WM), gray matter (GM), and lateral ventricle (cerebrospinal fluid [CSF]) of normal subjects, plaques, and normal appearing WM (NAWM) of MS subjects and glioma lesions were calculated. Mann-Whitney U test was used for comparison.
  
  
  RESULTS
  In normal subjects, MD values were 6.6 ± 0.2, 8.44 ± 0.41, and 17.08 ± 0.80 μm for WM, GM, and CSF, respectively, while those for NAWM and WM plaques in MS, and glioma lesions were significantly higher at 7.0 ± 0.17, 9.3 ± 2.3, and 9.6 ± 0.40 μm, respectively, compared to WM in normal subjects.
  
  
  CONCLUSIONS
  We propose that the relative values of MD obtained by QSI in control and diseased tissues can be useful for diagnosing various WM abnormalities.
authors: Department of Radiology, University of Yamanashi, Chuo-shi, Yamanashi, Japan.
authors: Zareen
authors: Z
authors: Fatima
authors: Utaroh
authors: U
authors: Motosugi
authors: Masaaki
authors: M
authors: Hori
authors: Keiichi
authors: K
authors: Ishigame
authors: Toshiyuki
authors: T
authors: Onodera
authors: Kazuo
authors: K
authors: Yagi
authors: Tsutomu
authors: T
authors: Araki
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005910:Glioma / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult