title: The coat protein leads the way: an update on basic and applied studies with the Brome mosaic virus coat protein.
abstract: The Brome mosaic virus (BMV) coat protein (CP) accompanies the three BMV genomic RNAs and the subgenomic RNA into and out of cells in an infection cycle. In addition to serving as a protective shell for all of the BMV RNAs, CP plays regulatory roles during the infection process that are mediated through specific binding of RNA elements in the BMV genome. One regulatory RNA element is the B box present in the 5' untranslated region (UTR) of BMV RNA1 and RNA2 that play important roles in the formation of the BMV replication factory, as well as the regulation of translation. A second element is within the tRNA-like 3' UTR of all BMV RNAs that is required for efficient RNA replication. The BMV CP can also encapsidate ligand-coated metal nanoparticles to form virus-like particles (VLPs). This update summarizes the interaction between the BMV CP and RNAs that can regulate RNA synthesis, translation and RNA encapsidation, as well as the formation of VLPs.
authors: Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA. ckao@indiana.edu
authors: C Cheng
authors: CC
authors: Kao
authors: Peng
authors: P
authors: Ni
authors: Masarapu
authors: M
authors: Hema
authors: Xinlei
authors: X
authors: Huang
authors: Bogdan
authors: B
authors: Dragnea
mesh_terms: D017795:Bromovirus / Q000235:genetics / Q000378:metabolism; D036022:Capsid Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D015967:Gene Expression Regulation, Viral; D017433:Protein Structure, Secondary; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism
chemical_list: D036022:Capsid Proteins; D012367:RNA, Viral; C430231:coat protein, Brome mosaic virus