title: Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases.
abstract: Immunoglobulin gene sequence analysis is widely utilized for prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called 'problematic sequences' that do not fit the 'classic' interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication.
authors: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: A W
authors: AW
authors: Langerak
authors: F
authors: F
authors: Davi
authors: P
authors: P
authors: Ghia
authors: A
authors: A
authors: Hadzidimitriou
authors: F
authors: F
authors: Murray
authors: K N
authors: KN
authors: Potter
authors: R
authors: R
authors: Rosenquist
authors: K
authors: K
authors: Stamatopoulos
authors: C
authors: C
authors: Belessi
mesh_terms: D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology*; D011379:Prognosis; D012015:Reference Standards; D017421:Sequence Analysis / Q000379:methods / Q000592:standards*
chemical_list: D007136:Immunoglobulins