title: Pathogenesis of neointima formation following vascular injury.
abstract: Revascularization remains the cornerstone of managing obstructive coronary artery disease. Although percutaneous coronary interventions involving the insertion of metal scaffolds, known as stents, has emerged as the preferred method of restoring vessel patency, as many as 30% of patients will experience a gradual re-narrowing of the lumen caused by neointima (NI) formation, resulting in a condition known as in-stent restenosis (ISR). ISR represents a significant limitation to percutaneous revascularization - however, abrogating NI formation following stent implantation has been hampered by an incomplete understanding of the pathogenesis of in-stent lesions. While numerous mechanisms have been proposed to explain the pathogenesis of ISR, data from human and animal models have yielded conflicting results. Herein, we review key studies of NI development following vascular injury with a focus on the origin of cells participating in NI formation.
authors: Division of Cardiology, University of Ottawa Heart Institute, Ontario, Canada.
authors: Edward R
authors: ER
authors: O' Brien
authors: Xiaoli
authors: X
authors: Ma
authors: Trevor
authors: T
authors: Simard
authors: Ali
authors: A
authors: Pourdjabbar
authors: Benjamin
authors: B
authors: Hibbert
mesh_terms: D023903:Coronary Restenosis / Q000473:pathology; D006801:Humans; D058426:Neointima / Q000473:pathology*; D057772:Vascular System Injuries / Q000473:pathology*