title: [Effects of high-fat diet on blood lipids in rats].
abstract: OBJECTIVE
  To provide a basis for establishing better animal models with hyperlipidemia by comparing the effects of two different high-fat diets on blood lipids of rats.
  
  
  METHODS
  30 male Wistar rats were randomly divided into 3 groups (10 rats in each group) , including normal control group (NC), high fat formula diet group I (HFFD I) and high fat formula diet group II (HFFD II). NC group was fed a stock rodent diet, the HFFD I and HFFD II were fed with different high-fat formulae diets. Animals were weighted weekly and blood lipids were determined every two weeks. The experiment lasted for 6 weeks.
  
  
  RESULTS
  By the end of the experiment, serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in HFFD I group were 1.4 and 2.2 times higher than those of the NC group (P < 0.01). Serum high-density lipoprotein cholesterol (HDL-C) was 22.2% lower than that of NC group. Serum triglyceride (TG) was not significantly different between HFFD I and NC group (P > 0.05). Serum TC and LDL-C of HFFD II group were 11.5 and 5.7 times respectively higher than those of the NC group (P < 0.01). Serum TG and HDL-C were 39.7% and 34.6% respectively lower than those of the NC group.
  
  
  CONCLUSIONS
  Animal models with hypercholesteremia can be successfully established by the two methods, but the serum TG level of the rats can not be significantly elevated.
authors: Department of Nutrition and Food Hygiene, Harbin Medical University, Harbin 150081, China. guofuchuan@163.com
authors: Fuchuan
authors: F
authors: Guo
authors: Ying
authors: Y
authors: Li
authors: Changhao
authors: C
authors: Sun
authors: Yucun
authors: Y
authors: Niu
authors: Rennan
authors: R
authors: Feng
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006937:Hypercholesterolemia; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004041:Dietary Fats; D008055:Lipids