title: X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).
abstract: The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)(2) DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form.
authors: Department of Chemistry Ugo Schiff, University of Firenze, Via della Lastruccia 3-13, I-50019 Sesto Fiorentino, Firenze, Italy.
authors: Marta
authors: M
authors: Ferraroni
authors: Carla
authors: C
authors: Bazzicalupi
authors: Anna Rita
authors: AR
authors: Bilia
authors: Paola
authors: P
authors: Gratteri
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism; D053119:Benzophenanthridines / Q000737:chemistry / Q000378:metabolism*; D001599:Berberine / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D003460:Crystallization; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D007364:Intercalating Agents / Q000737:chemistry / Q000378:metabolism; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000378:metabolism; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D053119:Benzophenanthridines; D007364:Intercalating Agents; D007546:Isoquinolines; D009838:Oligodeoxyribonucleotides; D001599:Berberine; D004247:DNA; C005705:sanguinarine