title: Plant NB-LRR signaling: upstreams and downstreams.
abstract: Plant disease resistance proteins commonly belong to the nucleotide binding-leucine rich repeat (NB-LRR) protein family. These specialized immune proteins mediate recognition of diverse pathogen-derived effector proteins and initiate potent defense responses. NB-LRRs exhibit a multidomain architecture and each domain appears to have discrete functions depending on the stage of NB-LRR signaling. Novel proteins that were found to interact with the core HSP90 chaperone complex regulate accumulation and activation of NB-LRR immune receptors. Recent studies have also advanced our understanding of how accessory proteins contribute to NB-LRR activation. The dynamic nature of NB-LRR localization to different subcellular compartments before and after activation suggests that NB-LRRs may activate immune responses in multiple parts of the cell. In this review we highlight recent advances in understanding NB-LRR function.
authors: Department of Plant Pathology, University of California, Davis, CA 95616, United States.
authors: James Mitch
authors: JM
authors: Elmore
authors: Zuh-Jyh Daniel
authors: ZJ
authors: Lin
authors: Gitta
authors: G
authors: Coaker
mesh_terms: D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D003593:Cytoplasm / Q000235:genetics / Q000378:metabolism; D060467:Disease Resistance; D018506:Gene Expression Regulation, Plant; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D000090263:Leucine-Rich Repeat Proteins; D010766:Phosphorylation; D010940:Plant Proteins / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D055550:Protein Stability; D011506:Proteins / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018841:HSP90 Heat-Shock Proteins; D000090263:Leucine-Rich Repeat Proteins; D010940:Plant Proteins; D011506:Proteins