title: Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistance.
abstract: OBJECTIVE
  We sought to determine the effect of an endothelin type A receptor antagonist (ETA) on uterine artery resistive index (UARI) and mean arterial pressure (MAP) in a placental ischemia rat model of preeclampsia produced by reduction in uterine perfusion pressure (RUPP).
  
  
  METHODS
  UARI was assessed by Doppler velocimetry in RUPP and normal pregnant controls (NP) on gestational days (GD) 12, 15, and 18. UARI was also determined on GD 18 in NP and RUPP pregnant dams after pretreatment with ETA. MAP was recorded on GD 19.
  
  
  RESULTS
  The RUPP group had a higher MAP and UARI on GD 15 and 18 than the NP group. Pretreatment with ETA attenuated both the MAP and GD-18 UARI in the RUPP group without affecting these parameters in the NP group.
  
  
  CONCLUSIONS
  The improvement in UARI could be one potential mechanism for the reduction in MAP in response to ETA in pregnant dams with ischemic placentas.
authors: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
authors: Kiran B
authors: KB
authors: Tam Tam
authors: Eric
authors: E
authors: George
authors: Kathy
authors: K
authors: Cockrell
authors: Marietta
authors: M
authors: Arany
authors: Joshua
authors: J
authors: Speed
authors: James N
authors: JN
authors: Martin
authors: Babbette
authors: B
authors: Lamarca
authors: Joey P
authors: JP
authors: Granger
mesh_terms: D000818:Animals; D000077868:Atrasentan; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D065128:Endothelin Receptor Antagonists; D005260:Female; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007511:Ischemia / Q000188:drug therapy / Q000503:physiopathology; D010920:Placenta / Q000098:blood supply* / Q000187:drug effects / Q000503:physiopathology; D011247:Pregnancy; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014463:Ultrasonography; D055988:Uterine Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects* / Q000502:physiology
chemical_list: D065128:Endothelin Receptor Antagonists; D011759:Pyrrolidines; D000077868:Atrasentan