title: Population-based patterns and predictors of prostate-specific antigen screening among older men in the United States.
abstract: OBJECTIVE
  For patients who elect to have prostate cancer screening, the optimal time to discontinue screening is unknown. Our objective was to describe rates and predictors of prostate-specific antigen (PSA) screening among older men in the United States.
  
  
  METHODS
  Data were extracted from the population-based 2000 and 2005 National Health Interview Survey (NHIS). PSA screening was defined as a PSA test as part of a routine exam within the past year. Demographic, socioeconomic, and functional characteristics were collected, and a validated 5-year estimated life expectancy was calculated. Age-specific rates of PSA screening were determined, and sampling weight-adjusted multivariate regressions were fitted to determine predictors of screening among men age 70 years or older.
  
  
  RESULTS
  The PSA screening rate was 24.0% in men age 50 to 54 years, and it increased steadily with age until a peak of 45.5% among age 70 to 74 years. Screening rates then gradually declined by age, and 24.6% of men age 85 years or older reported being screened. Among men age 70 years or older, screening rates varied by estimated 5-year life expectancy: rates were 47.3% in men with high life expectancies (≤ 15% probability of 5-year mortality), 39.2% in men with intermediate life expectancies (16% to 48% probability), and 30.7% in men with low life expectancies (> 48% probability; P < .001). In multivariate analysis, estimated life expectancy and age remained independently associated with PSA screening (P < .001 for each).
  
  
  CONCLUSIONS
  Rates of PSA screening in the United States are associated with age and estimated life expectancy, but excessive PSA screening in elderly men with limited life expectancies remains a significant problem. The merits and limitations of PSA should be discussed with all patients considering prostate cancer screening.
authors: University of Chicago Medical Center, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Michael W
authors: MW
authors: Drazer
authors: Dezheng
authors: D
authors: Huo
authors: Mara A
authors: MA
authors: Schonberg
authors: Aria
authors: A
authors: Razmaria
authors: Scott E
authors: SE
authors: Eggener
mesh_terms: D000367:Age Factors; D000368:Aged; D055088:Early Detection of Cancer / Q000706:statistics & numerical data*; D006801:Humans; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D014481:United States
chemical_list: D017430:Prostate-Specific Antigen