title: Rabies-prevention policy update: new reduced-dose schedule.
abstract: The Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention recommends reducing the number of doses from 5 to 4 of human diploid cell vaccine or purified chick embryo cell vaccine required for postexposure prophylaxis to prevent rabies in humans. The vaccine doses should be given on day 0 (first day of prophylaxis) and days 3, 7, and 14 after the first dose. For persons with immune suppression, the 5-dose regimen should continue to be used. Recommendations for the use of human rabies immunoglobulin remain unchanged. The American Academy of Pediatrics endorses these recommendations.
mesh_terms: D002648:Child; D004305:Dose-Response Relationship, Drug; D019983:Guideline Adherence; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007116:Immunization, Passive; D007117:Immunization, Secondary; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D011819:Rabies Vaccines