title: The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease.
abstract: Obestatin is a 23 amino acid, ghrelin gene-derived peptide hormone produced in the stomach and a range of other tissues throughout the body. While it was initially reported that obestatin opposed the actions of ghrelin with regards to appetite and food intake, it is now clear that obestatin is not an endogenous ghrelin antagonist, but it is a multi-functional peptide hormone in its own right. In this review we will discuss the controversies associated with the discovery of obestatin and explore emerging central and peripheral roles of obestatin, which includes adipogenesis, pancreatic homeostasis and cancer.
authors: Queensland University of Technology, Queensland, Brisbane, Australia.
authors: Inge
authors: I
authors: Seim
authors: Carina
authors: C
authors: Walpole
authors: Laura
authors: L
authors: Amorim
authors: Peter
authors: P
authors: Josh
authors: Adrian
authors: A
authors: Herington
authors: Lisa
authors: L
authors: Chopin
mesh_terms: D000818:Animals; D004194:Disease; D054439:Ghrelin / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006262:Health; D006801:Humans; D008954:Models, Biological
chemical_list: D054439:Ghrelin