title: Evaluation of uridine 5'-eicosylphosphate as a stimulant of cyclic AMP-dependent cellular function.
abstract: Sporulation of the yeast Saccharomyces cerevisiae is negatively regulated by cyclic AMP (cAMP). This microbial cell differentiation process was applied for the screening of a substance that can elevate the intracellular cAMP level. Among nucleoside 5'-alkylphosphates, uridine 5'-eicosylphosphate (UMPC20) selectively and predominantly inhibited ascospore formation of the yeast cells. We suppose the inhibitory effect of UMPC20 could indeed reflect the elevation of the cellular cAMP level.
authors: Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
authors: Masahiro
authors: M
authors: Yutani
authors: Akira
authors: A
authors: Ogita
authors: Ken-Ichi
authors: K
authors: Fujita
authors: Yoshinosuke
authors: Y
authors: Usuki
authors: Toshio
authors: T
authors: Tanaka
mesh_terms: D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D000242:Cyclic AMP / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism; D013938:Thymidine Monophosphate / Q000031:analogs & derivatives*; D014542:Uridine Monophosphate / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C407009:adenosine 5'-hexadecylphosphate; C558199:uridine 5'-eicosylphosphate; C409383:uridine 5'-hexadecylphosphate; D013938:Thymidine Monophosphate; D000249:Adenosine Monophosphate; D000242:Cyclic AMP; D014542:Uridine Monophosphate