title: Serologic imprint of dengue virus in urban Haiti: characterization of humoral immunity to dengue in infants and young children.
abstract: Dengue is endemic to Haiti but not recognized as an important illness in the autochthonous population. To evaluate the prevalence of antibodies to dengue virus (DENV), serum samples from infants and young children 7-36 months of age (n = 166) were assayed by plaque reduction neutralization assays to each DENV serotype. Dengue virus serotype 1 had infected 40% of this study population, followed by serotype 2 (12%), serotype 3 (11%), and serotype 4 (2%). Fifty-three percent of infants and young children less than 12 months of age had already experienced DENV infection, and the seroprevalence of antibody to DENV increased to 65% by 36 months. Heterotypic antibody responses were an important component of the total dengue immunity profile.
authors: Department of Pediatrics, Vanderbilt University, Nashville, TN, USA. meghan.rioth@vanderbilt.edu
authors: Meghan
authors: M
authors: Rioth
authors: Carole Anne
authors: CA
authors: Beauharnais
authors: Francine
authors: F
authors: Noel
authors: Mine R
authors: MR
authors: Ikizler
authors: Sapna
authors: S
authors: Mehta
authors: Yuwei
authors: Y
authors: Zhu
authors: Carole A
authors: CA
authors: Long
authors: Jean W
authors: JW
authors: Pape
authors: Peter F
authors: PF
authors: Wright
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology* / Q000276:immunology*; D003716:Dengue Virus / Q000145:classification / Q000276:immunology*; D005260:Female; D006801:Humans; D056724:Immunity, Humoral; D007223:Infant; D008297:Male; D012703:Serotyping; D014505:Urban Population
chemical_list: D000914:Antibodies, Viral