title: Is intractable epilepsy a tauopathy?
abstract: Tau exists in neuronal axons and glial cells of the central nervous system and contributes to the maintenance of the unique cell morphology. It functions in axon elongation, cell polarity formation and microtubule stabilization. Aggregates and hyper-phosphorylated tau proteins are classical components of neurofibrillary lesions in numerous neurodegenerative disorders, which are called "tauopathies". Recent studies have demonstrated that tau-associated genes and proteins and tau phosphorylation were abnormal in intractable epilepsy. Therefore, the discovery of the dysfunctional tau in intractable epilepsy opens a new window in the study of central tauopathy.
authors: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors: Zhi-Qin
authors: ZQ
authors: Xi
authors: Xue-Feng
authors: XF
authors: Wang
authors: Xiao-Fang
authors: XF
authors: Shu
authors: Guo-Jun
authors: GJ
authors: Chen
authors: Fei
authors: F
authors: Xiao
authors: Ji-Jun
authors: JJ
authors: Sun
authors: Xi
authors: X
authors: Zhu
mesh_terms: D004827:Epilepsy / Q000378:metabolism*; D006801:Humans; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016875:tau Proteins