title: Relationship between leptin and all-cause and cardiovascular mortality in chronic hemodialysis patients.
abstract: BACKGROUND
  We aimed to evaluate the relationship between serum leptin and the leptin/body mass index (BMI) ratio with prevalent cardiovascular disease (CVD), and their influence on all-cause and CVD-related mortality in patients on hemodialysis (HD).
  
  
  METHODS
  118 stable HD patients (50 women, median [interquartile range] age, 65.1 [54.7-72.2] years) were studied. All patients had baseline measurement of serum leptin concentrations. Relationships between leptin and all-cause and CVD mortality were studied by means of survival analysis and Cox regression analysis.
  
  
  RESULTS
  The leptin/BMI ratio was similar in patients with and without CVD at baseline (0.65 [0.29-2.23] vs. 0.68 [0.29-1.49] ng·m2/ml·kg, respectively, NS). Multiple logistic regression analysis showed that there was not an independent association between leptin/BMI ratio and prevalent CVD. During the follow-up time, 52 (44.1%) patients died. CVD was the cause of death in 27 out of 52 (51.9%) deceased patients. Survival analysis and Cox proportional multivariate regression analysis showed that there were no significant relationships between leptin levels or the leptin/BMI ratio and all-cause and CVD-related mortality.
  
  
  CONCLUSIONS
  These results do not support that, in stable HD patients, serum leptin concentrations and the leptin/BMI ratio are related with prevalent CVD. Leptin/BMI ratio seems not to be a risk factor for mortality in these patients.
authors: Servicio de Endocrinología, Hospital Ramón y Cajal, Madrid. jdiez.hrc@salud.madrid.org
authors: Juan José
authors: JJ
authors: Díez
authors: Maurizio
authors: M
authors: Bossola
authors: María José
authors: MJ
authors: Fernández-Reyes
authors: Enrico
authors: E
authors: Di Stasio
authors: Luigi
authors: L
authors: Tazza
authors: Giovanna
authors: G
authors: Luciani
authors: Rosa
authors: R
authors: Codoceo
authors: Pedro
authors: P
authors: Iglesias
authors: Astrid
authors: A
authors: Rodríguez
authors: Elena
authors: E
authors: González
authors: Rafael
authors: R
authors: Selgas
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood* / Q000401:mortality; D002423:Cause of Death; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000401:mortality / Q000628:therapy; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D016016:Proportional Hazards Models; D011446:Prospective Studies; D006435:Renal Dialysis / Q000706:statistics & numerical data; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D018709:Statistics, Nonparametric
chemical_list: D020738:Leptin