title: Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.
abstract: The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
authors: Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany.
authors: Timo A
authors: TA
authors: Immel
authors: Ulrich
authors: U
authors: Groth
authors: Thomas
authors: T
authors: Huhn
authors: Peter
authors: P
authors: Öhlschläger
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D004195:Disease Models, Animal; D005260:Female; D020128:Inhibitory Concentration 50; D051379:Mice; D014025:Titanium / Q000737:chemistry*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D014025:Titanium