title: Thrombophilias in pregnancy.
abstract: Thrombophilic conditions are associated with an increased risk of venous thromboembolic events (VTE) during pregnancy. Thrombophilic disorders are either acquired, as in antiphospholipid syndrome, or inherited, as in factor V Leiden. Both are associated with VTE but acquired disorders can also increase the risk of arterial events. However, there is controversy as to whether they may adversely affect other pregnancy outcomes including pregnancy loss, placental abruption, severe preeclampsia, and stillbirth. This article discusses the effect of thrombophilias on pregnancy.
authors: Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ebattinelli@partners.org
authors: E M
authors: EM
authors: Battinelli
authors: K A
authors: KA
authors: Bauer
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000628:therapy; D000037:Abruptio Placentae / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000628:therapy; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D005165:Factor V / Q000032:analysis / Q000235:genetics; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000628:therapy; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D050497:Stillbirth / Q000453:epidemiology / Q000235:genetics; D054556:Venous Thromboembolism / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000628:therapy
chemical_list: C095381:factor V Leiden; D005165:Factor V