title: [Effect of simvastatin on the function of MG63 cell line].
abstract: OBJECTIVE
  To investigate the effect of simvastatin on the function of MG63 cell line.
  
  
  METHODS
  The function of proliferation, osteoprotegerin (OPG) and osteocalcin (OC) gene expression, and migration of MG63 cells were detected with MTT, fluorescent real-time PCR and micro chemotaxis, respectively. The data was analyzed using ANOVA followed by Tukey test with SPSS14.0 software package.
  
  
  RESULTS
  10-9mol/L and 10-8mol/L concentrations of simvastatin slightly promoted MG63 cell proliferation; 10-7mol/L and 10-6mol/L concentrations of simvastatin greatly enhanced the OPG and OC mRNA expression; All concentrations of simvastatin had an inhibitory effect on MG63 cell migration.
  
  
  CONCLUSIONS
  Simvastatin could promote bone defect regeneration by enhancing the bone-related genes expression.
authors: Yantai Stomatological Hospital.Yantai 264001,Shandong Province, China. dentistliu@163.com
authors: Shu-Tai
authors: ST
authors: Liu
authors: Zhong-Hao
authors: ZH
authors: Liu
authors: Xiao-Ming
authors: XM
authors: Zong
authors: Zhi-Shan
authors: ZS
authors: Lu
authors: Hong-Chen
authors: HC
authors: Sun
authors: Rausch-Fan
authors: RF
authors: Xiaohui
mesh_terms: D001861:Bone Regeneration; D002460:Cell Line; D049109:Cell Proliferation; D006801:Humans; D010006:Osteoblasts; D015675:Osteocalcin; D053244:Osteoprotegerin; D019821:Simvastatin
chemical_list: D053244:Osteoprotegerin; D015675:Osteocalcin; D019821:Simvastatin