title: Water adherence factors for human skin.
abstract: On incidental dermal exposure to chemicals in water, a key exposure factor is the amount of water adhering to skin. Although soil adherence factors have been developed for risk assessment, measurements of water adherence on human skin have not been described. In the Environmental Protection Agency's (EPA's) dermal risk assessment guidance, dermal dose from environmental exposures is based upon the flux rate across the skin, which assumes that an unlimited amount of chemical is available for absorption. This assumption is applicable to certain exposure scenarios such as swimming and bathing. However, exposures to contaminated water frequently involve scenarios where the available chemical is limited by the amount of water adhering to the skin, for example, during accidental splashes.
authors: Scientific and Regulatory Affairs, Wm. Wrigley Jr. Company, Chicago, IL, USA. jaspreet.gujral@wrigley.com
authors: Jaspreet S
authors: JS
authors: Gujral
authors: Deborah M
authors: DM
authors: Proctor
authors: Steave H
authors: SH
authors: Su
authors: Joseph M
authors: JM
authors: Fedoruk
mesh_terms: D000268:Adhesiveness; D000328:Adult; D004781:Environmental Exposure; D005260:Female; D005528:Foot; D006197:Hair; D006225:Hand; D006801:Humans; D007101:Immersion; D007866:Leg; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000008:administration & dosage* / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical