title: Quantification of subarachnoid hemorrhage by three-dimensional computed tomography: correlation between hematoma volume and symptomatic vasospasm.
abstract: Subarachnoid hemorrhage (SAH) volume was measured by three-dimensional computed tomography (3D-CT) and the correlation examined between the SAH volume and the occurrence of symptomatic vasospasm (SVS). Experimental (in vitro) hematomas were made with blood obtained from 10 volunteers. The hematoma volume was determined by actual measurements and by 3D-CT using a CT number in the range of 40-80 Hounsfield units (HU) on days 1, 4, 7, 11, and 14. The coefficients on days 1 and 4 were relatively high and the correlation between measured and estimated volumes was significant on days 7, 11, and 14. 3D-CT was also performed in 50 patients with SAH at onset (day 0) and on days 1, 4, 7, and 14. The hematoma volume including the volume of normal structures was automatically calculated (V1). The volume of normal structures (V2) with CT numbers of 40-80 HU was calculated in another 50 patients without intracranial lesions as 12 ml. The total hematoma volume was defined as V1 minus mean V2. The mean SAH volume was 44, 36, 21, 11, and 8 ml on days 0, 1, 4, 7, and 14, respectively. The hematoma volumes were significantly larger in patients with SVS than in patients without SVS at all time points. The minimum hematoma volume in patients with SVS was 92, 76, 42, 24, and 12 ml on days 0, 1, 4, 7, and 14, respectively. This method allows the quantitative determination of SAH volume based on 3D-CT, and may be useful in clinical studies of cerebral vasospasm.
authors: Department of Neurosurgery, Fukushima Medical University, Fukushima, Japan.
authors: Taku
authors: T
authors: Sato
authors: Tatsuya
authors: T
authors: Sasaki
authors: Jun
authors: J
authors: Sakuma
authors: Tadashi
authors: T
authors: Watanabe
authors: Masahiro
authors: M
authors: Ichikawa
authors: Eiji
authors: E
authors: Ito
authors: Yuka
authors: Y
authors: Matsumoto
authors: Hitoshi
authors: H
authors: Ando
authors: Kiyoshi
authors: K
authors: Saito
authors: Katsuyuki
authors: K
authors: Kikori
authors: Takeshi
authors: T
authors: Yusa
authors: Kyouichi
authors: K
authors: Suzuki
authors: Yoichi
authors: Y
authors: Watanabe
authors: Satoshi
authors: S
authors: Taira
authors: Masahiro
authors: M
authors: Sato
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006406:Hematoma / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011237:Predictive Value of Tests; D012015:Reference Standards; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D020301:Vasospasm, Intracranial / Q000175:diagnosis* / Q000209:etiology