title: Rapidly progressive cutaneous Rhizopus microsporus infection presenting as Fournier's gangrene in a patient with acute myelogenous leukemia.
abstract: Members of the genus Rhizopus within the class Zygomycetes can cause devastating opportunistic infections. Cutaneous disease arising from direct inoculation of fungal spores has the potential to disseminate widely. Here, we describe a dramatic case of cutaneous Rhizopus infection involving the penis in a patient with acute myelogenous leukemia. Despite aggressive surgical debridement, systemic antifungal therapy, and donor lymphocyte infusion, the infection was ultimately fatal. This case illustrates the unique diagnostic and therapeutic challenges in the clinical management of cutaneous Rhizopus infection.
authors: Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland 21205, USA.
authors: C M
authors: CM
authors: Durand
authors: C D
authors: CD
authors: Alonso
authors: A P
authors: AP
authors: Subhawong
authors: N P
authors: NP
authors: Kwiatkowski
authors: M
authors: M
authors: Showel
authors: K C
authors: KC
authors: Carroll
authors: K A
authors: KA
authors: Marr
mesh_terms: D003881:Dermatomycoses / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology; D018450:Disease Progression; D018934:Fournier Gangrene / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology; D009894:Opportunistic Infections / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology; D010409:Penile Diseases / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology; D012233:Rhizopus / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity; D013997:Time Factors