title: Identification of triclosan intermediates produced by oxidative degradation using TiO2 in pure water and their endocrine disrupting activities.
abstract: The photodegradation pathways of 2-(2,4-dichlorophenoxy)-5-chlorophenol (triclosan) in water were studied. The main purposes were to identify structures of intermediates derived by radical reaction using TiO(2) advanced oxidation processes and to evaluate the endocrine disrupting activities in treated triclosan during oxidative reactions. Intermediates such as dichlorophenols, 2,8-dibenzo-p-dioxin, tetrachlorinated diphenyl ether (tetraclosan) and hydroxylated triclosan were produced by photoreaction. The estrogen, thyroid hormone and retinoid X receptor activities of the treated triclosan were measured with the yeast two-hybrid assay. It was found that tetraclosan and 2,4-dichlorophenol have stronger thyroid hormone activities than triclosan in the presence of S9.
authors: Graduate School of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, 3-1-100 Tsukide, Kumamoto 862-8502, Japan.
authors: K
authors: K
authors: Sankoda
authors: H
authors: H
authors: Matsuo
authors: M
authors: M
authors: Ito
authors: K
authors: K
authors: Nomiyama
authors: K
authors: K
authors: Arizono
authors: R
authors: R
authors: Shinohara
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000737:chemistry* / Q000633:toxicity; D052244:Endocrine Disruptors / Q000737:chemistry* / Q000633:toxicity; D009990:Oryzias / Q000378:metabolism; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D011960:Receptors, Estrogen / Q000378:metabolism; D047488:Retinoid X Receptors / Q000378:metabolism; D014025:Titanium / Q000737:chemistry*; D014260:Triclosan / Q000737:chemistry* / Q000633:toxicity; D014867:Water / Q000737:chemistry
chemical_list: D000891:Anti-Infective Agents, Local; D052244:Endocrine Disruptors; D011960:Receptors, Estrogen; D047488:Retinoid X Receptors; D014867:Water; C009495:titanium dioxide; D014260:Triclosan; D014025:Titanium