title: [Morphological analysis of bone dynamics and metabolic bone disease. A case report of recurrent renal hyperparathyroidism].
abstract: A 39-years-old chronic hemodialysis patient who developed recurrent hyperparathyroidism after total parathyroidectomy with immediate autotransplantation (PTX-AT) is now reported. The patient had undergone bilateral nephrectomy due to bilateral renal cell carcinoma at 4 and 5 years after the initiation of dialysis, followed by the treatment with interleukin-2 administration. Secondary hyperparathyroidism was treated by PTX-AT, followed by confirmation of reduced bone turnover. The parathyroid glands were huge and the total weight of the parathyroid glands was 14.3 gr. Pathological examination revealed nodular hyperplastic parathyroid tissue in all four glands. However, the serum intact parathyroid hormone (iPTH) increased again at 7 years after the PTX, and bone biopsy revealed high turnover bone disease. The recurrent hyperparathyroidism was treated with cinacalcet hydrochloride to reduce the serum iPTH level.
authors: Department of Urology and Dialysis Unit, Towa Hospital / Department of Transplant and Endocrine Surgery, Nagoya Second Red Cross Hospital / Division of Renal replacement Therapeutic Science, Department of Urology, Akita University School of Medicine.
authors: Aiji
authors: A
authors: Yajima
authors: Yoshihiro
authors: Y
authors: Tominaga
authors: Shigeru
authors: S
authors: Satoh
authors: Shigeru
authors: S
authors: Otsubo
authors: Masaaki
authors: M
authors: Inaba
authors: Kosaku
authors: K
authors: Nitta
authors: Akemi
authors: A
authors: Ito
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000601:surgery; D000069449:Cinacalcet; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000473:pathology / Q000628:therapy*; D007680:Kidney Neoplasms / Q000150:complications / Q000601:surgery; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use; D009392:Nephrectomy; D016105:Parathyroidectomy; D012008:Recurrence; D006435:Renal Dialysis; D013997:Time Factors; D014182:Transplantation, Autologous
chemical_list: D009281:Naphthalenes; D000069449:Cinacalcet