title: Acute leukoencephalopathy after buprenorphine intoxication in a 2-year-old child.
abstract: Leukoencephalopathies have been reported after heroin inhalation or ingestion, and buprenorphine injection, but the physiopathology remains unclear. We report here the first case of leukoencephalopathy caused by buprenorphine ingestion in a 2-year-old child who was admitted for coma and fever. Due to technical problems, the toxicology screen was delayed, and infectious disease was first suspected. A brain MRI found bilateral and symmetric white matter damages in the cerebral hemispheres and the cerebellum. Rapid recovery and positive toxicology screen for buprenorphine on day 4 confirmed the diagnosis of acute intoxication.
authors: Unité de Réanimation Pédiatrique et Néonatale et Brûlés Pédiatriques, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalier Universitaire Nord, Chemin des Bourrely, 13915 Marseille, Cedex 20, France.
authors: Blandine
authors: B
authors: Bellot
authors: Fabrice
authors: F
authors: Michel
authors: Laurent
authors: L
authors: Thomachot
authors: Kathia
authors: K
authors: Chaumoitre
authors: Fabrice
authors: F
authors: Battaglia
authors: Pierre
authors: P
authors: Lagier
mesh_terms: D000208:Acute Disease; D000701:Analgesics, Opioid / Q000506:poisoning*; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D002047:Buprenorphine / Q000506:poisoning*; D002675:Child, Preschool; D003128:Coma / Q000139:chemically induced; D005334:Fever / Q000139:chemically induced; D006801:Humans; D056784:Leukoencephalopathies / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine