title: Hepatitis B virus infection: a favorable prognostic factor for intrahepatic cholangiocarcinoma after resection.
abstract: OBJECTIVE
  To study the prognostic factors for intrahepatic cholangiocarcinoma (ICC) and evaluate the impact of chronic hepatitis B virus (HBV) infection on survival rate of ICC patients.
  
  
  METHODS
  A total of 155 ICC patients who underwent macroscopic curative resections (R0 and R1) were enrolled in this retrospective study and divided into group A with HBV infection and group B without HBV infection according to their chronic HBV infection, represented by positive hepatitis B surface antigen (HBsAg) in serum or in liver tissue. Clinicopathological characteristics and survival rate of the patients were evaluated.
  
  
  RESULTS
  All patients underwent anatomical resection. Their 1- and 3-year survival rates were 60.6% and 32.1%, respectively. Multivariate analyses revealed that HBV infection, hepatolithiasis, microscopic satellite lesion, and lymphatic metastasis were the independent prognostic factors for the survival rate of ICC patients. The median disease-free survival time of the patients was 5.0 mo. The number of tumors, microscopic satellite lesion, and vascular invasion were the independent prognostic factors for the disease-free survival rate of the patients. The prognostic factors affecting the survival rate of ICC patients with HBV infection and those without HBV infection were not completely consistent. Alkaline phosphatase > 119 U/L, microscopic satellite lesion, vascular invasion, and lymphatic metastasis were the independent factors for the patients with HBV infection, while r-glutamyltransferase > 64 U/L, microscopic satellite lesion, and poor tumor differentiation were the independent factors for the patients without HBV infection.
  
  
  CONCLUSIONS
  HBV infection is a valuable clinical factor for predicting tumor invasiveness and clinical outcome of ICC patients. ICC patients with HBV infection should be distinguished from those without HBV infection because they have different clinicopathological characteristics, prognostic factors and outcomes after surgical resection.
authors: Department of Comprehensive Treatment II, Second Military Medical University, Shanghai 200433, China.
authors: Hua-Bang
authors: HB
authors: Zhou
authors: Hui
authors: H
authors: Wang
authors: Yu-Qiong
authors: YQ
authors: Li
authors: Shuang-Xi
authors: SX
authors: Li
authors: Hao
authors: H
authors: Wang
authors: Dong-Xun
authors: DX
authors: Zhou
authors: Qian-Qian
authors: QQ
authors: Tu
authors: Qing
authors: Q
authors: Wang
authors: Shan-Shan
authors: SS
authors: Zou
authors: Meng-Chao
authors: MC
authors: Wu
authors: He-Ping
authors: HP
authors: Hu
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000821:virology; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000601:surgery / Q000821:virology; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis* / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000378:metabolism*; D006515:Hepatitis B virus / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000821:virology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000821:virology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D006514:Hepatitis B Surface Antigens