title: Do cilia put brakes on the cell cycle?
abstract: Two papers in this issue show that dynein-binding proteins may regulate the G1-S transition through an effect on cilia. Nde1, a known partner of dynein light chain LC8, controls ciliary length in vitro and in zebrafish, and influences the G1-S progression. The phosphorylation of Tctex1, a dynein light chain, modulates cilia length and accelerates G1-S, thereby regulating proliferation-differentiation decisions in the developing mouse neocortex.
authors: Peter K
authors: PK
authors: Jackson
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D002923:Cilia / Q000378:metabolism*; D004398:Dyneins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D008869:Microtubule-Associated Proteins
chemical_list: D018797:Cell Cycle Proteins; C533386:Dynlt1b protein, mouse; D008869:Microtubule-Associated Proteins; C531336:Nde1 protein, mouse; D004398:Dyneins