title: How to test nontarget effects of veterinary pharmaceutical residues in livestock dung in the field.
abstract: To register veterinary medicinal products (VMPs) as parasiticides on pastured animals, legislation in the European Union requires an environmental risk assessment to test the potential nontarget effects of fecal residues on dung-dwelling organisms. Products with adverse effects in single-species laboratory tests require further, higher-tier testing to assess the extent of these effects on entire communities of dung-dwelling organisms under more realistic field or semifield conditions. Currently, there are no documents specifically written to assist researchers in conducting higher-tier tests or to assist regulators in interpreting the results of such tests in an appropriate context. Here we provide such a document, written by members of the SETAC Advisory Group DOTTS (Dung Organism Toxicity Testing Standardization) with research experience on dung fauna in central and southern Europe, Canada, Australia, and South Africa. This document briefly reviews the organisms that make up the dung community and their role in dung degradation, identifies key considerations in the design and interpretation of experimental studies, and makes recommendations on how to proceed.
authors: Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
authors: Ralf
authors: R
authors: Jochmann
authors: Wolf U
authors: WU
authors: Blanckenhorn
authors: Luc
authors: L
authors: Bussière
authors: Charles E
authors: CE
authors: Eirkson
authors: John
authors: J
authors: Jensen
authors: Ute
authors: U
authors: Kryger
authors: Joost
authors: J
authors: Lahr
authors: Jean-Pierre
authors: JP
authors: Lumaret
authors: Jörg
authors: J
authors: Römbke
authors: Keith G
authors: KG
authors: Wardhaugh
authors: Kevin D
authors: KD
authors: Floate
mesh_terms: D000818:Animals; D005243:Feces / Q000737:chemistry*; D058751:Livestock; D018570:Risk Assessment / Q000379:methods*; D019155:Veterinary Drugs / Q000633:toxicity*
chemical_list: D019155:Veterinary Drugs