title: Frequency-invariant representation of interaural time differences in mammals.
abstract: Interaural time differences (ITDs) are the major cue for localizing low-frequency sounds. The activity of neuronal populations in the brainstem encodes ITDs with an exquisite temporal acuity of about 10 μs. The response of single neurons, however, also changes with other stimulus properties like the spectral composition of sound. The influence of stimulus frequency is very different across neurons and thus it is unclear how ITDs are encoded independently of stimulus frequency by populations of neurons. Here we fitted a statistical model to single-cell rate responses of the dorsal nucleus of the lateral lemniscus. The model was used to evaluate the impact of single-cell response characteristics on the frequency-invariant mutual information between rate response and ITD. We found a rough correspondence between the measured cell characteristics and those predicted by computing mutual information. Furthermore, we studied two readout mechanisms, a linear classifier and a two-channel rate difference decoder. The latter turned out to be better suited to decode the population patterns obtained from the fitted model.
authors: Department of Biology II, Ludwig-Maximilians Universität München, Planegg-Martinsried, Germany.
authors: Hannes
authors: H
authors: Lüling
authors: Ida
authors: I
authors: Siveke
authors: Benedikt
authors: B
authors: Grothe
authors: Christian
authors: C
authors: Leibold
mesh_terms: D000465:Algorithms; D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D005849:Gerbillinae; D016014:Linear Models; D008297:Male; D008959:Models, Neurological; D015233:Models, Statistical; D009474:Neurons / Q000502:physiology; D016011:Normal Distribution; D016012:Poisson Distribution; D013017:Sound Localization / Q000502:physiology*; D013997:Time Factors