title: A preliminary study of silicone hydrogel lens material and care solution bioincompatibilities.
abstract: OBJECTIVE
  The study purpose was to evaluate corneal barrier function and staining relative to potential bioincompatibilities.
  
  
  METHODS
  This was a randomized double-masked study (n = 25 subjects). Three lens material-care solution combinations were tested: (1) lotrafilcon B/polyhexamethylene biguanide (PHMB)-based multipurpose (MPS) solution (MPS-1); (2) lotrafilcon B/polyquaternium-1 and myristamidopropyl dimethylamine-based solution (MPS-2); and (3) lotrafilcon B and another PHMB-based solution (MPS-3). Saline served as the control. New lenses were soaked in the preserved solutions or saline and then worn for 2 hours before corneal measurements. Barrier function was characterized by the fluorescein penetration rate, corneal amount, both measured with an objective scanning fluorometer. The dye penetration rate ratio, test to control; amount ratio, test to control, and corneal staining were evaluated.
  
  
  RESULTS
  The mean rate ratios (± SD) for the combinations were 2.98 (± 3.04), 1.23 (± 1.01), and 1.83 (± 1.77) for MPS-1, MPS-2, and MPS-3 solutions, respectively. Significant ratio differences were found across regimens (P = 0.007); for MPS-1 compared with baseline (P = 0.031) and for MPS-1 compared with MPS-2 (P = 0.007). The statistical results for staining were similar.
  
  
  CONCLUSIONS
  Use of an objective quantitative physiological method suggests that significant differences in lens solution bioincompatibilities occur that mirror corneal staining data relative to corneal compromise.
authors: Department of Basic Science, Southern California College of Optometry, Fullerton, CA, USA. jpaugh@scco.edu
authors: Jerry R
authors: JR
authors: Paugh
authors: Andrew Loc
authors: AL
authors: Nguyen
authors: Jonathan Q
authors: JQ
authors: Hall
authors: Daniel
authors: D
authors: Krall
authors: Justin R
authors: JR
authors: Webb
authors: Alison C
authors: AC
authors: Ramsey
authors: David L
authors: DL
authors: Meadows
mesh_terms: D000328:Adult; D001645:Biguanides / Q000009:adverse effects; D018639:Contact Lens Solutions / Q000009:adverse effects*; D003263:Contact Lenses, Hydrophilic; D018592:Cross-Over Studies; D004311:Double-Blind Method; D019573:Epithelium, Corneal / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D019793:Fluorescein / Q000378:metabolism; D015590:Fluorophotometry; D006801:Humans; D020100:Hydrogels; D008297:Male; D008422:Materials Testing; D010539:Permeability; D011108:Polymers / Q000009:adverse effects; D011437:Propylamines / Q000009:adverse effects; D012030:Refractive Errors / Q000628:therapy; D012828:Silicones; D013194:Staining and Labeling; D055815:Young Adult
chemical_list: D001645:Biguanides; D018639:Contact Lens Solutions; D020100:Hydrogels; D011108:Polymers; D011437:Propylamines; D012828:Silicones; C524582:lotrafilcon B; C031233:polihexanide; C058655:polyquaternium 1; D019793:Fluorescein; C401661:myristamidopropyl dimethylamine