title: An amyloid-like fibril-forming supramolecular cross-β-structure of a model peptide: a crystallographic insight.
abstract: The peptide Boc-Val-Phe-OMe 1 bearing sequence similarity with the central hydrophobic cluster (CHC) of Alzheimer's Aβ(18-19) peptide self-assembles to produce amyloid-like straight unbranched fibrils as examined by atomic force microscopy and Congo red assay. Single crystal X-ray diffraction offers the atomic level structure of the supramolecular parallel β-sheet aggregation and antiparallel separation between layers (cross-β-structure).
authors: Department of Chemical Sciences, Indian Institute of Science Education and Research-Kolkata, Mohanpur, Nadia, West Bengal, India.
authors: Sibaprasad
authors: S
authors: Maity
authors: Pankaj
authors: P
authors: Kumar
authors: Debasish
authors: D
authors: Haldar
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D055503:Protein Multimerization; D017433:Protein Structure, Secondary
chemical_list: D016229:Amyloid beta-Peptides