title: Treatment of peri-implantitis with deproteinised bovine bone and tetracycline: a case report.
abstract: OBJECTIVE
  The objective of this study is to evaluate the use of tetracycline in a patient with peri-implantitis.
  
  
  BACKGROUND
  Tetracycline is widely used in regeneration procedures owing to its positive effect with bone graft material, regeneration of extraction socket bone and its traditional antibacterial effect. However, there have been limited reports on bone graft procedures combined with tetracycline application in peri-implantitis.
  
  
  METHODS
  The detoxification procedure was performed with chlorhexidine and tetracycline, and the defect area was grafted with a 4:1 volume ratio combination of deproteinised bovine bone mixed with tetracycline.
  
  
  RESULTS
  Soft tissue healing was uneventful, and the treatment yielded improved clinical results with a reduced probing depth.
  
  
  CONCLUSIONS
  Tetracycline was used in the treatment of peri-implantitis by burnishing the implant surface and applying tetracycline in conjunction with an osseous graft to the defect area. The treatment of peri-implantitis with tetracycline seemed to show improved clinical results up to the follow-up period.
authors: Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA. jbassoonis@yahoo.co.kr
authors: Jun-Beom
authors: JB
authors: Park
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003475:Curettage; D003646:Debridement; D059605:Dental Implant-Abutment Design; D015921:Dental Implants; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D057873:Peri-Implantitis / Q000188:drug therapy / Q000601:surgery*; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008903:Minerals; D013752:Tetracycline; C010882:chlorhexidine gluconate; D002710:Chlorhexidine