title: MicroRNAs: potential biomarker in organ transplantation.
abstract: MicroRNAs (miRs) are non-coding RNAs that could regulate gene expression at the posttranscriptional level, and have been indicated to be involved in diverse biological processes. They are emerging as master regulator of immune response and may likely play a key role in transplant rejection process. The extensive and comprehensive use of miR microarrays has enabled the identification of miRs as potential biomarkers for transplantation; many miRs have been reported associated with transplant rejection. Here we reviewed the emerging data on transplant recipients' miRs expression pattern, and discussed the possible mechanism of how miRs regulate transplant immune response.
authors: Key Laboratory of Transplant Engineering and Immunology of Health Ministry of China, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, PR China.
authors: Juan
authors: J
authors: Shan
authors: Li
authors: L
authors: Feng
authors: Lei
authors: L
authors: Luo
authors: Wenqiao
authors: W
authors: Wu
authors: Chengwen
authors: C
authors: Li
authors: Shengfu
authors: S
authors: Li
authors: Youping
authors: Y
authors: Li
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D015316:Genetic Therapy / Q000639:trends; D006084:Graft Rejection / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D035683:MicroRNAs / Q000032:analysis / Q000235:genetics*; D046228:Microarray Analysis; D016377:Organ Transplantation; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D035683:MicroRNAs