title: The discovery of SYP-10913 and SYP-11277: novel strobilurin acaricides.
abstract: BACKGROUND
  As previously reported, methyl (E)-2-[2-(2-phenylamino-6-trifluoromethylpyrimidin-4-yloxymethyl)phenyl]-3-methoxyacrylate has proven to be a new lead with highly acaricidal activity. Following on from this, in an effort to discover new strobilurin analogues with improved activity, a series of substituted pyrimidines were synthesised and bioassayed.
  
  
  RESULTS
  All compounds were characterised by (1) H NMR, IR, MS and elemental analysis. Preliminary bioassays demonstrated that some of the title compounds exhibited notable control of Tetranychus cinnabarinus (Boisd.) at 1.25 mg L(-1) . The relationship between structure and acaricidal activity is discussed.
  
  
  CONCLUSIONS
  Two compounds of particular interest, 6j (SYP-10913) and 6k (SYP-11277), exhibited potent acaricidal activity. The acaricidal potencies of these analogues are higher than that of fluacrypyrim in greenhouse applications, and are comparable with those of commercial acaricides such as spirodiclofen and propargite in field trials.
authors: State Key Laboratory of the Discovery and Development of Novel Pesticides, Shenyang Research Institute of the Chemical Industry, Shenyang, China.
authors: Bao-Shan
authors: BS
authors: Chai
authors: Chang-Ling
authors: CL
authors: Liu
authors: Hui-Chao
authors: HC
authors: Li
authors: Hong
authors: H
authors: Zhang
authors: Shao-Wu
authors: SW
authors: Liu
authors: Guang
authors: G
authors: Huang
authors: Jun-Biao
authors: JB
authors: Chang
mesh_terms: D056810:Acaricides / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D055808:Drug Discovery; D007887:Fabaceae / Q000469:parasitology; D005260:Female; D008297:Male; D008925:Mites / Q000187:drug effects*; D015394:Molecular Structure; D010935:Plant Diseases / Q000469:parasitology; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D013329:Structure-Activity Relationship
chemical_list: D056810:Acaricides; D011743:Pyrimidines