title: Unusual nucleotide content of Rubella virus genome as a consequence of biased RNA-editing: comparison with Alphaviruses.
abstract: The usage of cytosine in third codon positions of 22 complete Rubella virus genomes (52.4%) is significantly higher than the usage of guanine (28.9%), adenine (6.9%) and uracil (11.8%). The percentage of U ↔ C transitions (55%) between 22 Rubella virus genomes is two times higher than the percentage of A ↔ G transitions (23%). Predicted microRNA from ORF1 of Rubella virus may target human APOBEC1 mRNA, blocking APOBEC1-editing of viral RNA-minus and RNA-plus strands (preventing G → A and C → U transitions, respectively), while their ADAR-editing (causing U → C and A → G transitions, respectively) occurs frequently.
authors: Department of General Chemistry, Belarussian State Medical University, Minsk 220000, Belarus. vvkhrustalev@mail.ru
authors: Vladislav Victorovich
authors: VV
authors: Khrustalev
authors: Eugene Victorovich
authors: EV
authors: Barkovsky
mesh_terms: D000071479:APOBEC-1 Deaminase; D000465:Algorithms; D000524:Alphavirus / Q000235:genetics* / Q000378:metabolism*; D001482:Base Composition; D001483:Base Sequence; D003062:Codon / Q000235:genetics; D019295:Computational Biology; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism; D016679:Genome, Viral; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D009690:Nucleic Acid Conformation; D016366:Open Reading Frames; D010802:Phylogeny; D017393:RNA Editing; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D012412:Rubella virus / Q000235:genetics* / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D003062:Codon; D035683:MicroRNAs; D012367:RNA, Viral; D000071479:APOBEC-1 Deaminase; C000605089:APOBEC1 protein, human; D003564:Cytidine Deaminase