title: Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole.
abstract: In an earlier study in rodents, we showed that the aromatase that converts androgens to estrogens in the preoptic area and bed nucleus of stria terminalis was significantly increased in concentration after exposure to anabolic-androgenic steroids. To confirm whether this occurs in primates, we conducted a positron emission tomographic study using macaque monkeys. Male rhesus monkeys were treated with nandrolone decanoate for 3 weeks. To measure aromatase concentrations, we performed positron emission tomographic imaging using a 11C-labeled specific aromatase inhibitor, [11C]vorozole. After treatment with nandrolone, significant increase in [11C]vorozole binding was observed in the hypothalamus but not other areas including the amygdala, which is also aromatase enriched. These findings in monkeys are consistent with those we obtained earlier in rats. These findings strongly suggest that aromatase in the hypothalamus may play a crucial role in the emotional instability of anabolic-androgenic steroids abusers.
authors: RIKEN Center for Molecular Imaging Science, Chuo-ku, Kobe, Hyogo, Japan. kayo.takahashi@riken.jp
authors: Kayo
authors: K
authors: Takahashi
authors: Kayo
authors: K
authors: Onoe
authors: Hisashi
authors: H
authors: Doi
authors: Hiroko
authors: H
authors: Nagata
authors: Gen
authors: G
authors: Yamagishi
authors: Takamitsu
authors: T
authors: Hosoya
authors: Yasuhisa
authors: Y
authors: Tamura
authors: Yasuhiro
authors: Y
authors: Wada
authors: Hajime
authors: H
authors: Yamanaka
authors: Chihiro
authors: C
authors: Yokoyama
authors: Hiroshi
authors: H
authors: Mizuma
authors: Tadayuki
authors: T
authors: Takashima
authors: Mats
authors: M
authors: Bergström
authors: Hirotaka
authors: H
authors: Onoe
authors: Bengt
authors: B
authors: Långström
authors: Yasuyoshi
authors: Y
authors: Watanabe
mesh_terms: D045930:Anabolic Agents / Q000494:pharmacology*; D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D001141:Aromatase / Q000096:biosynthesis* / Q000378:metabolism; D002250:Carbon Radioisotopes; D007031:Hypothalamus / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000201:enzymology*; D008253:Macaca mulatta; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods; D014230:Triazoles
chemical_list: D045930:Anabolic Agents; D000728:Androgens; D002250:Carbon Radioisotopes; D014230:Triazoles; C060523:vorozole; D001141:Aromatase