title: The identification of unipolar mania subtype based on anxiety comorbidity.
abstract: BACKGROUND
  Unipolar mania is a controversial topic. Clinical research has focused on establishing specific characteristics that allow it to be distinguished from bipolar disorder (BD).
  
  
  METHODS
  Experienced and carefully trained clinicians evaluated a clinical sample of 298 patients with bipolar disorder using structured instruments to analyze the clinical and socio-demographics differences between people with manic episodes over the course of a 15-year illness compared with participants with histories of manic and depressive episodes.
  
  
  RESULTS
  According to adopted criteria, 16 (5.6%) participants presented unipolar mania (UM) and 282 participants presented manic and depressive (MD) phases. UM patients reported significantly more hospitalizations and medications, as well as more frequent psychosis at the first episode in the UM group than compared to the MD group. The UM group showed worse overall functioning, although differences in mood status between groups were not identified. Comorbid anxiety disorders and anxiety symptoms occurred significantly less frequently in the UM group.
  
  
  CONCLUSIONS
  Because of the cross-sectional design, determining causal relationships was not possible. Furthermore, the retrospective nature of the UM diagnosis could not exclude a future depressive episode.
  
  
  CONCLUSIONS
  The presence of anxiety disorders can differentiate patients with unipolar mania from those with bipolar mania.
authors: University Hospital- Psychiatry Service, Universidade Federal da Bahia, Salvador, BA, Brazil. monica@uefs.br
authors: Mônica
authors: M
authors: Andrade-Nascimento
authors: Ângela
authors: Â
authors: Miranda-Scippa
authors: Fabiana
authors: F
authors: Nery-Fernandes
authors: Flavio
authors: F
authors: Kapczinski
authors: Lucas C
authors: LC
authors: Quarantini
mesh_terms: D000328:Adult; D000339:Affect; D001007:Anxiety / Q000523:psychology; D001714:Bipolar Disorder / Q000145:classification / Q000175:diagnosis* / Q000523:psychology*; D003863:Depression / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000175:diagnosis; D012720:Severity of Illness Index