title: Enteral and parenteral nutrition in the conservative treatment of pancreatic fistula: a randomized clinical trial.
abstract: OBJECTIVE
  Postoperative pancreatic fistula is the most common and potentially life-threatening complication after pancreatic surgery. Although nutritional support is a key component of conservative therapy in such cases, there have been no well-designed clinical trials substantiating the superiority of either total parenteral nutrition or enteral nutrition. This study was conducted to compare the efficacy and safety of both routes of nutritional intervention.
  
  
  METHODS
  A randomized clinical trial was conducted in a tertiary surgical center of pancreatic and gastrointestinal surgery. Seventy-eight patients with postoperative pancreatic fistula were treated conservatively and randomly assigned to groups receiving for 30 days either enteral nutrition or total parenteral nutrition. The primary end point was the 30-day fistula closure rate.
  
  
  RESULTS
  After 30 days, closure rates in patients receiving enteral and parenteral nutrition were 60% (24 of 40) and 37% (14 of 38), respectively (P=.043). The odds ratio for the probability that fistula closes on enteral nutrition compared to total parenteral nutrition was 2.571 (95% confidence interval [CI]: 1.031-6.411). Median time to closure was 27 days (95% CI: 21-33) for enteral nutrition, and no median time was reached in total parenteral nutrition (P=.047). A logistic regression analysis identified only 2 factors significantly associated with fistula closure, ie, enteral nutrition (odds ratio=6.136; 95% CI: 1.204-41.623; P=.043) and initial fistula output of ≤200 mL/day (odds ratio=12.701; 95% CI: 9.102-47.241; P<.001).
  
  
  CONCLUSIONS
  Enteral nutrition is associated with significantly higher closure rates and shorter time to closure of postoperative pancreatic fistula.
authors: 1st Department of Surgery, Jagiellonian University Medical College, Krakow, Poland. klek@poczta.onet.pl
authors: Stanislaw
authors: S
authors: Klek
authors: Marek
authors: M
authors: Sierzega
authors: Lukasz
authors: L
authors: Turczynowski
authors: Piotr
authors: P
authors: Szybinski
authors: Kinga
authors: K
authors: Szczepanek
authors: Jan
authors: J
authors: Kulig
mesh_terms: D000368:Aged; D016009:Chi-Square Distribution; D004750:Enteral Nutrition / Q000009:adverse effects; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010185:Pancreatic Fistula / Q000628:therapy*; D010288:Parenteral Nutrition / Q000009:adverse effects; D011044:Poland; D011183:Postoperative Complications / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome