title: Morphologic study of the drainage pathway using a tracer after a bypass filtering procedure in rabbit eyes.
abstract: OBJECTIVE
  To study the drainage pathway using a tracer after a modified filtering surgery in rabbit eyes.
  
  
  METHODS
  The authors performed trabeculectomy combined with deep sclerectomy on one eye (TS group) and trabeculectomy on the other eye (T group) of 20 rabbits. Cationic ferritin was injected intracamerally just before killing the rabbits at postsurgical week 2, 4, 8, 12, or 24. The opposite side of the surgical site was used as the control. Histologic study was conducted under light microscopy.
  
  
  RESULTS
  In both groups, significantly more intrascleral and episcleral drainage vessels were observed than in the paired controls (P < .001). Intrascleral drainage canals were more often manifested in the TS group than in the T group (P < .05), especially after week 12.
  
  
  CONCLUSIONS
  Intrascleral and episcleral outflow were the main drainage routes after filtering surgeries in this model. Compared with trabeculectomy, the modified surgery was superior for forming an intrascleral "bleb" and seemed to be better maintained at a later stage.
authors: Eye Department of the 1st Affiliated Hospital of the Medical College of Xi'an Jiaotong University, Xi'an, Shannxi, China. minqizhang@163.com
authors: Jianqin
authors: J
authors: Lei
authors: Naixue
authors: N
authors: Sun
authors: Xiaoge
authors: X
authors: Zhao
authors: Qianyan
authors: Q
authors: Kang
authors: Li
authors: L
authors: Chen
authors: Xiaojuan
authors: X
authors: Fan
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects; D001082:Aqueous Humor / Q000378:metabolism*; D005293:Ferritins; D011817:Rabbits; D012599:Sclerostomy; D014130:Trabeculectomy
chemical_list: C010297:polycationic ferritin; D005293:Ferritins