title: Keloid formation after syndactyly release in patients with associated macrodactyly: management with methotrexate therapy.
abstract: We present a series of cases of keloid formation after release of syndactyly in the hands and feet of children with associated digital overgrowth. The use of methotrexate to suppress keloid formation after release of syndactyly and for control of recurrence after surgery for keloid is effective.
authors: The Department of Hand Surgery and Peripheral Nerve Surgery, Royal North Shore Hospital, University of Sydney, Australia.
authors: S K
authors: SK
authors: Tolerton
authors: M A
authors: MA
authors: Tonkin
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D058128:Compression Bandages; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005385:Fingers / Q000002:abnormalities* / Q000601:surgery; D005492:Folic Acid / Q000627:therapeutic use; D005500:Follow-Up Studies; D005532:Foot Deformities, Congenital / Q000601:surgery*; D006228:Hand Deformities, Congenital / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007627:Keloid / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000188:drug therapy* / Q000601:surgery; D012086:Reoperation; D055502:Secondary Prevention; D013576:Syndactyly / Q000601:surgery*; D014034:Toes / Q000002:abnormalities* / Q000601:surgery
chemical_list: D003879:Dermatologic Agents; D005492:Folic Acid; D008727:Methotrexate