title: Investigation of Hypericum perforatum extract on convulsion induced by picrotoxin in mice.
abstract: Therapeutic effect of Hypericum perforatum L. has been well known. The aim of this study is to investigate the anticonvulsant effects of Hypericum methanolic extract against seizure induced by picrotoxin in mice. The study were performed on four groups of animals. They received percolated extract of Hypericum perforatum at the doses of 25, 50, 100 & 200 mg/kg intra peritoneally. After 20 minutes animals received picrotoxin 10 mg/kg for induction of seizure. Latency of seizure, duration of seizure, death latency and percent of mortality were determined. The results indicated that latency of seizure increased in pretreated group with the dose of 50 mg/kg (p<0.01). The higher dose of extract 200 mg/kg significantly decrease duration of seizure and death latency. It maybe due to unknown ingredients in this plant or producing concentrations higher than the therapeutic level. The results showed that Hypericum perforatum L. at the dose of 50 mg/kg maybe have some beneficial effect in seizure induced by picrotoxin and this plant is suitable for continuing search in this field.
authors: Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Leila
authors: L
authors: Etemad
authors: Mahmoud Reza
authors: MR
authors: Heidari
authors: Mohammad
authors: M
authors: Heidari
authors: Mohammad
authors: M
authors: Moshiri
authors: Effat
authors: E
authors: Behravan
authors: Mitra
authors: M
authors: Abbasifard
authors: Behzad Sarvar
authors: BS
authors: Azimzadeh
mesh_terms: D000818:Animals; D020902:Hypericum; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010852:Picrotoxin; D010936:Plant Extracts / Q000627:therapeutic use*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D010852:Picrotoxin; D010936:Plant Extracts