title: [Oral glucose tolerance test and insulin response in Beagle dogs after subtotal distal gastrectomy].
abstract: OBJECTIVE
  To evaluate the impact of reconstruction techniques after subtotal gastrectomy on postoperative glucose and insulin levels after oral glucose tolerance test (OGTT).
  
  
  METHODS
  Distal gastrectomy was performed in 38 Beagle dogs. Reconstruction techniques used included integral continual jejunal interposition (n=9), Billroth I( (n=6), Billroth II( (n=7), and isolated jejunal interposition (n=8). Eight controls were used. OGTT was conducted to examine the changes in glucose and insulin levels.
  
  
  RESULTS
  Compared to controls, glucose significantly increased in all the 4 operative groups and peaked at 60 min. Billroth II( was associated with the most significant increase. Insulin level significantly increased in all the experimental groups in response to food stimulus and peaked at 60 min. However, the increase of insulin in Billroth II( group was not as prominent as in other groups.
  
  
  CONCLUSIONS
  Fluctuation of blood glucose after gastrectomy may be mitigated and insulin elevated if duodenal passage is preserved. Continual jejunal interposition should be given priority when Billroth I( reconstruction is not feasible.
authors: Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, China. yezaiyuan@126.com
authors: Zai-Yuan
authors: ZY
authors: Ye
authors: Wei
authors: W
authors: Zhang
authors: Qin
authors: Q
authors: Zhang
authors: Qiao-Qiong
authors: QQ
authors: Dai
authors: Qin-Shu
authors: QS
authors: Shao
authors: Yuan-Shui
authors: YS
authors: Sun
authors: Yuan-Yu
authors: YY
authors: Wang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D013505:Digestive System Surgical Procedures / Q000379:methods*; D004285:Dogs; D005260:Female; D005743:Gastrectomy / Q000379:methods; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood*; D008297:Male
chemical_list: D001786:Blood Glucose; D007328:Insulin