title: Fluorometric sensing of biogenic amines with aggregation-induced emission-active tetraphenylethenes.
abstract: A fluorometric sensor for detection and identification of biogenic amines with carboxylic acid modified tetraphenylethenes (TPEs) based on aggregation-induced emission (AIE) is reported. A mixture of the carboxylic acid substituted TPE and biogenic amines displayed a blue emission on aggregation, which serves as a "turn-on" fluorescent sensor for the amines, the degree of fluorescence enhancement being dependent on the amine. The chromic responses were utilized to distinguish the amines. A fluorometric sensor array of three TPEs with carboxylic acid groups was shown to identify accurately 10 different amines, including biogenic amines. The response patterns were systematically classified by using linear discriminant analysis (LDA) with 98% classification accuracy. Additional information on the concentration of histamine in a "tuna fish matrix" as an example was assessed by the further analysis of the fluorescence intensity, demonstrating a test for food freshness and quality.
authors: Chemical Resources Laboratory, Tokyo Institute of Technology, 4259-R1-13 Nagatsuta, Yokohama 226-8503, Japan.
authors: Mitsutaka
authors: M
authors: Nakamura
authors: Takanobu
authors: T
authors: Sanji
authors: Masato
authors: M
authors: Tanaka
mesh_terms: D000818:Animals; D001679:Biogenic Amines / Q000032:analysis*; D002264:Carboxylic Acids / Q000737:chemistry; D005030:Ethylenes / Q000737:chemistry*; D005504:Food Analysis / Q000592:standards; D006632:Histamine / Q000032:analysis*; D015394:Molecular Structure; D017747:Seafood; D013050:Spectrometry, Fluorescence; D014413:Tuna
chemical_list: D001679:Biogenic Amines; D002264:Carboxylic Acids; D005030:Ethylenes; D006632:Histamine