title: Occurrence of overactive bladder in patients with benign prostatic hyperplasia in the Czech Republic.
abstract: BACKGROUND
  Bladder outlet obstruction (BOO) due to prostatic hyperplasia is often accompanied by overactive bladder (OAB) symptoms, which often disappear after specific BOO pharmacotherapy. The aim of this study was to map out the spectrum in BOO pharmacotherapy to find out the occurrence of OAB in this population and to find its treatment.
  
  
  METHODS
  Follow-up consists of a retrospective and a prospective part, which includes all the patient's data related to the lower urinary tract symptoms in BOO and OAB. In all, 654 data record forms were distributed during the study and 98% of those were validated.
  
  
  RESULTS
  According to our observations, alpha-blockers were used most frequently at the beginning of BOO treatment (73%), followed by phytopharmaca (19.9%) and finally finasteride (5.5%). If the treatment is changed, the proportion of finasteride increases. Only a small number of patients with BOO and OAB are treated in combination with antimuscarinics.
  
  
  CONCLUSIONS
  A combined therapy (alpha-blocker + antimuscarinics) is effective in a majority of men with infravesical obstruction and symptoms of OAB. However, OAB in our study was primarily underdiagnosed in almost 50% of all patients treated for LUTS.
authors: Department of Urology, Charles University, 1st Faculty of Medicine, Prague, Czech Republic.
authors: T
authors: T
authors: Hanuš
authors: L
authors: L
authors: Zámečník
authors: T
authors: T
authors: Doležal
authors: Z
authors: Z
authors: Karmazínová
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018153:Czech Republic; D018120:Finasteride / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000494:pharmacology; D015995:Prevalence; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000473:pathology*; D012189:Retrospective Studies; D001748:Urinary Bladder Neck Obstruction / Q000188:drug therapy / Q000473:pathology; D053201:Urinary Bladder, Overactive / Q000150:complications* / Q000175:diagnosis*
chemical_list: D018727:Muscarinic Antagonists; D018120:Finasteride