title: Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
abstract: Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16β,17α,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation.
authors: Institute of Chemistry, University of Białystok , Piłsudskiego 11/4, 15-443 Białystok, Poland.
authors: Jadwiga
authors: J
authors: Maj
authors: Jacek W
authors: JW
authors: Morzycki
authors: Lucie
authors: L
authors: Rárová
authors: Jana
authors: J
authors: Oklest'ková
authors: Miroslav
authors: M
authors: Strnad
authors: Agnieszka
authors: A
authors: Wojtkielewicz
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis; D053148:Caspase 3 / Q000378:metabolism; D053179:Caspase 7 / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002783:Cholestenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004789:Enzyme Activation; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002783:Cholestenones; D012503:Saponins; C106408:OSW 1; D053148:Caspase 3; D053179:Caspase 7