title: SCORE Study report #11: incidences of neovascular events in eyes with retinal vein occlusion.
abstract: OBJECTIVE
  To investigate in The Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study: (1) incidences of neovascular events and retinal capillary nonperfusion (abbreviated as "nonperfusion"), and their relationship with treatment groups; (2) neovascular incidences by nonperfusion status; and (3) pertinent baseline factors for their potential risk for neovascular events.
  
  
  METHODS
  Two multicenter, randomized clinical trials, 1 evaluating participants with central retinal vein occlusion (CRVO) and the other evaluating participants with branch retinal vein occlusion (BRVO).
  
  
  METHODS
  At 36 months, data were available for 81 participants with CRVO and 128 with BRVO.
  
  
  METHODS
  Standard care (observation or grid photocoagulation) versus 1 or 4 mg intravitreal triamcinolone.
  
  
  METHODS
  Neovascularization of the iris (NVI), neovascular glaucoma (NVG), disc or retinal neovascularization (NVD/NVE), preretinal or vitreous hemorrhage (PRH/VH), and nonperfusion.
  
  
  RESULTS
  The cumulative 36-month incidences for CRVO and BRVO eyes, respectively, were 8.5% and 2.4% for NVI or NVG; 8.8% and 7.6% for NVD/NVE or PRH/VH. There were no differences in incidences of neovascular events or risk of nonperfusion when comparing the 3 treatment groups within diseases. For CRVO at 36 months, 16.6% of eyes with ≥5.5 disc areas of nonperfusion versus 4.0% of eyes with <5.5 disc areas of nonperfusion developed NVG (P = 0.0003); for BRVO at 36 months, 14.6% versus 2.4% developed NVD/NVE (P<0.0001). Similar results were noted for most other neovascular events. Nonperfusion was the only significant baseline factor for neovascularization in BRVO, with the risk of a neovascular event increasing with greater disc areas of nonperfusion, and the highest risk noted at ≥5.5 disc areas.
  
  
  CONCLUSIONS
  In the SCORE Study, triamcinolone treatment was not associated with lower incidences of neovascular events or nonperfusion status compared with observation or grid photocoagulation. Cumulative 36-month incidences for most neovascular events were significantly higher for nonperfused than perfused eyes. Greater baseline disc areas of nonperfusion increased the risk of neovascularization in BRVO but not CRVO eyes, possibly owing to obscuration of retinal capillary details caused by dense hemorrhage at baseline for CRVO eyes. Increased risk of neovascularization was noted below the historical threshold of 10 disc areas of nonperfusion for retinal vein occlusion.
authors: Southern California Desert Retina Consultants, Palm Springs, CA, USA.
authors: Clement K
authors: CK
authors: Chan
authors: Michael S
authors: MS
authors: Ip
authors: Paul C
authors: PC
authors: Vanveldhuisen
authors: Neal L
authors: NL
authors: Oden
authors: Ingrid U
authors: IU
authors: Scott
authors: Michael J
authors: MJ
authors: Tolentino
authors: Barbara A
authors: BA
authors: Blodi
mesh_terms: D000368:Aged; D002196:Capillaries; D005260:Female; D015355:Glaucoma, Neovascular / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D007498:Iris / Q000098:blood supply; D007511:Ischemia / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D008028:Light Coagulation; D016014:Linear Models; D008297:Male; D009389:Neovascularization, Pathologic / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D012166:Retinal Hemorrhage / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D015861:Retinal Neovascularization / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D012170:Retinal Vein Occlusion / Q000150:complications / Q000628:therapy*; D012171:Retinal Vessels; D018570:Risk Assessment; D014221:Triamcinolone / Q000627:therapeutic use*; D014823:Vitreous Hemorrhage / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control
chemical_list: D005938:Glucocorticoids; D014221:Triamcinolone