title: Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products.
abstract: A number of indolizines and pyrrolo[1,2-a]quinolines/isoquinolines were prepared from phenacyl pyridinium, quinolinium and isoquinolinium salts derived from the reaction of the heterocycles with 2-bromo acetophenone with alkynes and alkenes using amberlite-IRA-402 (OH) ion exchange resin as the base. Antibacterial and antifungal studies were carried out against thirteen bacterial and four fungal strains, which revealed that three derivatives (4a, 4b, 7a) out of fifteen are effective against all the thirteen strains and one derivative, 10, showed dual antibactericidal and antifungal efficacy.
authors: Department Of Chemistry, Indian Institute of Chemical Biology, Council of Scientific & Industrial Research, 4, Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, India.
authors: Abhijit
authors: A
authors: Hazra
authors: Shyamal
authors: S
authors: Mondal
authors: Arindam
authors: A
authors: Maity
authors: Subhendu
authors: S
authors: Naskar
authors: Pritam
authors: P
authors: Saha
authors: Rupankar
authors: R
authors: Paira
authors: Krishnendu B
authors: KB
authors: Sahu
authors: Priyankar
authors: P
authors: Paira
authors: Soma
authors: S
authors: Ghosh
authors: Chandrima
authors: C
authors: Sinha
authors: Amalesh
authors: A
authors: Samanta
authors: Sukdeb
authors: S
authors: Banerjee
authors: Nirup B
authors: NB
authors: Mondal
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D007212:Indolizines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007475:Ion Exchange Resins / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007212:Indolizines; D007475:Ion Exchange Resins; D007546:Isoquinolines; D011804:Quinolines