title: Increased Golgi protein 73 expression in hepatocellular carcinoma tissue correlates with tumor aggression but not survival.
abstract: OBJECTIVE
  Serum Golgi protein 73 (sGP73) is a novel and promising biomarker for hepatocellular carcinoma (HCC). However, there are few reports on the pattern of GP73 expression in HCC and the relationship of this expression to clinicopathologic features of patients. This study aimed to investigate the expression of GP73 and it correlation with clinical parameters.
  
  
  METHODS
  We examined GP73 expression in HCC and adjacent paracarcinomatous liver (PCL) tissue in 36 HCC patients, and took 14 normal liver (NL) samples from hepatic hemangioma patients. Western blot analysis and quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR) were used for analyses.
  
  
  RESULTS
  GP73 expression in HCC was significantly higher than in the corresponding PCL and NL samples at both protein and mRNA levels (P < 0.001). The elevated level of GP73 protein was strongly associated with tumor size, vein invasion, and tumor differentiation, suggesting augmented tumor invasion and metastasis. However, there was no association between GP73 expression and patient survival.
  
  
  CONCLUSIONS
  Significant overexpression of GP73 at both protein and mRNA levels along with overexpression of GP73 protein is associated with aggressive behavior of HCC, but not overall patient survival. Further research is needed to determine the potential of GP73 as a therapeutic target.
authors: Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Beijing, China.
authors: Yongliang
authors: Y
authors: Sun
authors: Huayu
authors: H
authors: Yang
authors: Yilei
authors: Y
authors: Mao
authors: Haifeng
authors: H
authors: Xu
authors: Jinchun
authors: J
authors: Zhang
authors: Guangbing
authors: G
authors: Li
authors: Xin
authors: X
authors: Lu
authors: Xinting
authors: X
authors: Sang
authors: Haitao
authors: H
authors: Zhao
authors: Shouxian
authors: S
authors: Zhong
authors: Jiefu
authors: J
authors: Huang
authors: Hongbing
authors: H
authors: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D015153:Blotting, Western; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000235:genetics* / Q000401:mortality; D002681:China / Q000453:epidemiology; D004273:DNA, Neoplasm / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000235:genetics* / Q000401:mortality; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D015996:Survival Rate / Q000639:trends
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C410824:GOLM1 protein, human; D008565:Membrane Proteins