title: Correlation of haloperidol levels between saliva and plasma of acutely ill schizophrenic patients.
abstract: OBJECTIVE
  Clinical usefulness of monitoring haloperidol in salivary samples based on plasma:saliva correlation.
  
  
  METHODS
  Plasma and saliva samples of schizophrenic patients [N=105] were analyzed by highly sensitive reverse phase liquid chromatographic method to measure haloperidol at 240 nm using UV-PDA detector. Mobile phase consist of acetonitrile and water [50:50], pH 2.5 (0.1% acetic acid and 0.05 M KHPO(4)) at flow rate 1.4 mL/min. Method was linear over 3-200 ng/mL.
  
  
  RESULTS
  Observed therapeutic range was 5-19 ng/mL [11.66±3.97] and 17-54 ng/mL [27.52±11.51] for plasma and saliva respectively. Mean S:P was found to be 2.36.
  
  
  CONCLUSIONS
  Current study showed significantly high correlation [r=0.93, p<0.0001] between haloperidol levels in saliva and plasma with linear relationship. It is therefore concluded that monitoring of salivary concentration can be a clinically beneficial substitute. Patients showing clinical improvement [N=90] were within salivary concentration range of 17-54 ng/mL, which can be an appropriate steady state monitoring range for haloperidol in saliva.
authors: Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur-342001 (Rajasthan), India. jain0291@gmail.com
authors: Tarun
authors: T
authors: Jain
authors: Anil
authors: A
authors: Bhandari
authors: Veerma
authors: V
authors: Ram
authors: Sanjay
authors: S
authors: Sharma
authors: Manish
authors: M
authors: Parakh
authors: Mahaveer Chand
authors: MC
authors: Parakh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006220:Haloperidol / Q000097:blood* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D015394:Molecular Structure; D012463:Saliva / Q000737:chemistry*; D012559:Schizophrenia / Q000097:blood* / Q000378:metabolism*; D055815:Young Adult
chemical_list: D006220:Haloperidol