title: Health technology assessment in the era of personalized health care.
abstract: OBJECTIVE
  This article examines the challenges for health technology assessment (HTA) in the light of new developments of personalized health care, focusing on European HTA perspectives.
  
  
  METHODS
  Using the example of the Integrated Genome Research Network - Mutanom (IG Mutanom) project, with focus on personalized cancer diagnostics and treatment, we assess the scope of current HTA and examine it prospectively in the context of the translation of basic and clinical research into public health genomics and personalized health care.
  
  
  RESULTS
  The approaches developed within the IG-Mutanom project are based on innovative technology potentially providing targeted therapies for cancer; making translation into clinical practice requires a novel course of action, however. New models of HTA are needed that can account for the unique types of evidence inherent to individualized targeted therapies. Using constructive health technology assessment (CTA) models is an option, but further suitable models should be developed.
  
  
  CONCLUSIONS
  Integrative, systems biology-based approaches toward personalized medicine call for novel assessment methods. The translation of their highly innovative technologies into the practice of health care requires the development of new HTA concepts.
authors: Maastricht University, Maastricht, The Netherlands and Agency for Health Technology Assessment in Poland, Warsaw, Poland. l.becla@aotm.gov.pl
authors: Lidia
authors: L
authors: Becla
authors: Jeantine E
authors: JE
authors: Lunshof
authors: David
authors: D
authors: Gurwitz
authors: Tobias
authors: T
authors: Schulte In den Bäumen
authors: Hans V
authors: HV
authors: Westerhoff
authors: Bodo M H
authors: BM
authors: Lange
authors: Angela
authors: A
authors: Brand
mesh_terms: D004059:Diffusion of Innovation; D005060:Europe; D023281:Genomics / Q000639:trends*; D006291:Health Policy; D006295:Health Resources; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D011446:Prospective Studies; D049490:Systems Biology; D013673:Technology Assessment, Biomedical / Q000639:trends*