title: Preparation, characterization, and topical delivery of paromomycin ion pairing.
abstract: Topical chemotherapy with paromomycin (PA) has been used as an alternative for the treatment of cutaneous leishmaniasis; however, poor skin penetration of this drug limits the efficacy of formulations. The objective of this work was to study the ability of the PA free base to form ion pairing with organic acids, as well as evaluate the effect of these compounds on the topical delivery of PA. PA permeation across intact skin was low, while drug penetration into skin from PA ion pairing was the higher than that observed for the PA base. Data obtained on the stripped skin, a damaged skin model, clearly showed that the ion pairing presented a potential to improve PA skin permeation.
authors: Departmento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (MG), Brazil.
authors: Isabel R L
authors: IR
authors: Nogueira
authors: Guilherme
authors: G
authors: Carneiro
authors: Maria Irene
authors: MI
authors: Yoshida
authors: Renata B
authors: RB
authors: de Oliveira
authors: Lucas A M
authors: LA
authors: Ferreira
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D007477:Ions; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy; D023421:Models, Animal; D010303:Paromomycin / Q000008:administration & dosage* / Q000737:chemistry; D010539:Permeability; D012867:Skin / Q000187:drug effects*; D013552:Swine
chemical_list: D000900:Anti-Bacterial Agents; D007477:Ions; D010303:Paromomycin