title: Chemokine CXCL11 links microbial stimuli to intestinal inflammation.
abstract: Interleukin (IL)-17 plays an important role in the pathogenesis in a number of immune inflammatory disorders. This study aims to investigate the mechanism by which microbial product flagellin is involved in the development of T helper type (Th)17 cells. Serum levels of IL-17 and CXCL9-11 in patients with ulcerative colitis (UC) were evaluated. The source and mechanism of CXC11 release in intestinal mucosa were examined with colonic biopsies from UC patients and a colitis mouse model. The role of flagellin in the development of Th17 cells was studied with a cell co-culture system. High serum levels of CXCL11 and IL-17 were observed in UC. Flagellin could induce the production of CXCL11 in CD14(+) cells that facilitated the development of Th17 cells. In a skewed Th1 response environment flagellin induces intestinal inflammation, with IL-17 expression predominant. CXCR3/CXCL11 pathway is involved in microbial product flagellin-induced intestinal inflammation in which the Th17 response plays an important role.
authors: Department of Gastroenterology, Tenth People's Hospital of Shanghai, Tongji University, Shanghai, China.
authors: Z
authors: Z
authors: Liu
authors: X
authors: X
authors: Chen
authors: X
authors: X
authors: Wang
authors: X
authors: X
authors: Chen
authors: C-H
authors: CH
authors: Song
authors: Y
authors: Y
authors: Du
authors: J
authors: J
authors: Su
authors: S A
authors: SA
authors: Yaseen
authors: P-C
authors: PC
authors: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D054371:Chemokine CXCL11 / Q000097:blood*; D003093:Colitis, Ulcerative / Q000097:blood / Q000139:chemically induced / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D005408:Flagellin / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007249:Inflammation; D020381:Interleukin-17 / Q000097:blood*; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008875:Middle Aged; D058408:Th1-Th2 Balance; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D014302:Trinitrobenzenesulfonic Acid / Q000008:administration & dosage
chemical_list: D054371:Chemokine CXCL11; D020381:Interleukin-17; D005408:Flagellin; D014302:Trinitrobenzenesulfonic Acid