title: Synthesis and anti-tumor evaluation of panaxadiol derivatives.
abstract: A series of panaxadiol derivatives have been synthesized by the simple acylation of the 3-hydroxy group of panaxadiol. The anti-tumor activities of the synthesized compounds were evaluated against a panel of human tumor cell lines by the standard MTT assay. Compounds 2, 11, 12, 13, 14, 15 and 16 showed stronger antiproliferative activities than that of Rg3 and PD on the growth of the distinct cancer cell lines in vitro.
authors: Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, 1829 Juzi St., Yanji 133000, PR China.
authors: Xue-Kun
authors: XK
authors: Liu
authors: Bai-Jun
authors: BJ
authors: Ye
authors: Yan
authors: Y
authors: Wu
authors: Zhen-Hua
authors: ZH
authors: Lin
authors: Yu-Qing
authors: YQ
authors: Zhao
authors: Hu-Ri
authors: HR
authors: Piao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D036145:Ginsenosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D036145:Ginsenosides; C004564:panaxadiol