title: Oral lipid based drug delivery system (LBDDS): formulation, characterization and application: a review.
abstract: The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. This may lead to high inter- and intra subject variability, lack of dose proportionality and therapeutic failure. The improvement of bio-availability of drugs with such properties presents one of the greatest challenges in drug formulations. Oral lipid based formulations are attracting considerable attention due to their capacity to increase the solubility, facilitating gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water soluble, lipophilic drug and thus increasing the bioavailability. The present review outlines the recent findings on self-emulsifying drug delivery system (SEDDS), self-micro/nanoemulsifying drug delivery system (SMEDDS/SNEDDS) and evaluation of these formulations published over the past decade. The application of lipid based formulations as a promising system for the oral delivery of many therapeutic agents including traditional medicine (TM) has also been examined in the current review.
authors: SLT institute of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur-495009, India. rahmanpharma@gmail.com
authors: Md Akhlaquer
authors: MA
authors: Rahman
authors: Ranjit
authors: R
authors: Harwansh
authors: Mohd Aamir
authors: MA
authors: Mirza
authors: Sarfaraj
authors: S
authors: Hussain
authors: Arshad
authors: A
authors: Hussain
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D045703:Emulsifying Agents / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D045703:Emulsifying Agents; D008055:Lipids