title: Lipid droplet associated proteins: an emerging role in atherogenesis.
abstract: Coronary heart disease and stroke, caused by rupture of atherosclerotic plaques in the arterial wall, are the major causes of death in industrialized countries. A key event in the pathogenesis of atherosclerosis is the transformation of smooth muscle cells and in particular of macrophages into foam cells, a result of massive accumulation of lipid droplets. It is well known that the formation of these lipid droplets is a result of the uninhibited uptake of modified lipoproteins by scavenger receptors. However, only more recently has it become apparent that a special set of lipid droplet associated proteins - the PAT protein family (perilipin, adipophilin, TIP47, S3-12 and OXPAT) - is fundamental to the formation, growth, stabilization and functions of lipid droplets. Here we review recent findings and assess the current state of knowledge on lipid droplets and their PAT proteins in atherogenesis.
authors: Leibniz Institute for Arteriosclerosis Research, University of Münster, Münster, Germany. insa.buers@lifa-muenster.de
authors: Insa
authors: I
authors: Buers
authors: Oliver
authors: O
authors: Hofnagel
authors: Anneke
authors: A
authors: Ruebel
authors: Nicholas J
authors: NJ
authors: Severs
authors: Horst
authors: H
authors: Robenek
mesh_terms: D000818:Animals; D050197:Atherosclerosis; D002352:Carrier Proteins / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000096:biosynthesis; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008055:Lipids / Q000737:chemistry*; D008565:Membrane Proteins / Q000096:biosynthesis; D051379:Mice; D008822:Mice, Transgenic; D009124:Muscle Proteins / Q000096:biosynthesis; D000070778:Perilipin-1; D000070780:Perilipin-2; D000070796:Perilipin-3; D000071229:Perilipin-4; D000070797:Perilipin-5; D010750:Phosphoproteins / Q000096:biosynthesis; D011257:Pregnancy Proteins / Q000096:biosynthesis; D033921:Vesicular Transport Proteins
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008055:Lipids; D008565:Membrane Proteins; D009124:Muscle Proteins; C516105:OXPAT protein, mouse; C000602982:PLIN2 protein, human; C038196:PLIN3 protein, human; C544352:PLIN5 protein, human; D000070778:Perilipin-1; D000070780:Perilipin-2; D000070796:Perilipin-3; D000071229:Perilipin-4; D000070797:Perilipin-5; D010750:Phosphoproteins; C000602983:Plin2 protein, mouse; C523440:Plin3 protein, mouse; C487119:Plin4 protein, mouse; D011257:Pregnancy Proteins; D033921:Vesicular Transport Proteins