title: [Polymorphism of repair genes and cytogenetic radiation effects].
abstract: For 99 healthy volunteers, the frequencies of spontaneous and y-induced (1 Gy in vitro) chromosome aberrations in blood lymphocytes were compared with the results of PCR-genotyping by 8 repair genes: XRCC1, XPD, ERCC1, APEXI, RAD23B, OGG1, ATM, Tp53 (in all, 10 polymorphic sites). The frequency of spontaneous aberrations of chromosome type increased additively with the number of copies of minor allele of excision repair gene XPD variant *2251G and *862A D (p = 0.025). The frequency of gamma-induced chromosome aberrations proved to be elevated for the carriers of a minor allele OGG1*977G (p = 0.011). The significantly elevated number of gamma-induced chromosome aberrations was also observed for the carriers of major alleles XRCC1*G1996 and XRCC1*C589 (p = 0.002).
authors: L E
authors: LE
authors: Sal'nikova
authors: A G
authors: AG
authors: Chumachenko
authors: I N
authors: IN
authors: Vesnina
authors: N Sh
authors: NSh
authors: Lapteva
authors: G I
authors: GI
authors: Kuznetsova
authors: S K
authors: SK
authors: Abilev
authors: A V
authors: AV
authors: Rubanovich
mesh_terms: D000328:Adult; D000483:Alleles; D002869:Chromosome Aberrations / Q000528:radiation effects*; D020732:Cytogenetic Analysis; D004260:DNA Repair / Q000235:genetics / Q000528:radiation effects*; D005720:Gamma Rays; D005838:Genotype; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D011110:Polymorphism, Genetic; D055815:Young Adult