title: Liposome surface charge influence on skin penetration behaviour.
abstract: Vesicular systems have shown their ability to increase dermal and transdermal drug delivery. Their mechanism of drug transport into and through the skin has been investigated but remains a much debated question. Several researchers have outlined that drug penetration can be influenced by modifying the surface charge of liposomes. In the present work we study the influence of particle surface charge on skin penetration. The final purpose is the development of a carrier system which is able to enhance the skin delivery of two model drugs, betamethasone and betamethasone dipropionate. Liposomes were characterised by their size, morphology, zeta potential, encapsulation efficiency and stability. Ex vivo diffusion studies using Franz diffusion cells were performed. Confocal microscopy was performed to visualise the penetration of fluorescently labelled liposomes into the skin. This study showed the potential of negatively charged liposomes to enhance the skin penetration of betamethasone and betamethasone dipropionate.
authors: Laboratory of Pharmaceutical Technology, Department of Pharmacy, CIRM, University of Liège, CHU, Tour 4, Bat B36, 1 Avenue de l'Hôpital, 4000 Liège, Belgium. aline.gillet@ulg.ac.be
authors: A
authors: A
authors: Gillet
authors: P
authors: P
authors: Compère
authors: F
authors: F
authors: Lecomte
authors: P
authors: P
authors: Hubert
authors: E
authors: E
authors: Ducat
authors: B
authors: B
authors: Evrard
authors: G
authors: G
authors: Piel
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001623:Betamethasone / Q000031:analogs & derivatives / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D004355:Drug Stability; D005938:Glucocorticoids / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D008081:Liposomes / Q000737:chemistry* / Q000493:pharmacokinetics; D009994:Osmolar Concentration; D010316:Particle Size; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D013499:Surface Properties; D013552:Swine
chemical_list: D004337:Drug Carriers; D005938:Glucocorticoids; D008081:Liposomes; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone