title: Antiproliferative activity of levobupivacaine and aminoimidazole carboxamide ribonucleotide on human cancer cells of variable bioenergetic profile.
abstract: We assessed the impact of ten mitoactive drugs on the viability and the proliferation of human cancer cells of variable origin and bioenergetics. A validated chemotherapeutic drug, doxorubicin, was used as a gold-standard for comparison. We also looked at the effect of these drugs on Rho(0) cells and on embryonic fibroblasts, both of which rely mainly on glycolysis to generate the vital ATP. The statistical analysis of the area under the curves revealed a cell-type specific response to mitodopant and mitotoxic compounds, in correlation with the contribution of glycolysis to cellular ATP synthesis. These findings indicate that the bioenergetic state of the cell determines in part the impact of mitodopants and mitotoxics on cancer cells viability.
authors: EA4576 MRGM-Maladies Rares: Génétique et Métabolisme, F-33076 Bordeaux, France.
authors: Caroline
authors: C
authors: Jose
authors: Nadège
authors: N
authors: Bellance
authors: Etienne Hébert
authors: EH
authors: Chatelain
authors: Giovanni
authors: G
authors: Benard
authors: Karine
authors: K
authors: Nouette-Gaulain
authors: Rodrigue
authors: R
authors: Rossignol
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002045:Bupivacaine / Q000031:analogs & derivatives / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D000077554:Levobupivacaine; D008297:Male; D012265:Ribonucleotides / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D012265:Ribonucleotides; D000620:Aminoimidazole Carboxamide; D000255:Adenosine Triphosphate; D000077554:Levobupivacaine; C031143:AICA ribonucleotide; D002045:Bupivacaine