title: In vivo visualization of endolyphatic hydrops in patients with Meniere's disease: correlation with audiovestibular function.
abstract: Our objective is to determine whether the degree of endolymphatic hydrops as it is detected in vivo in patients with definite Meniere's disease correlates with audiovestibular function. In this prospective study, 37 patients with definite Meniere's disease according to AAO-HNS criteria were included. Intratympanic contrast enhanced temporal bone MRI was performed using a 3D FLAIR protocol. The degree of endolymphatic hydrops in the cochlea and the vestibulum was graded on a Likert scale (0-3). The degree of hydrops was then analyzed with respect to its correlation with audiometric hearing levels, electrocochleographic SP/AP ratios, interaural amplitude ratios of vestibular evoked myogenic potentials and degree of horizontal semicircular canal paresis on caloric irrigation. There was a significant correlation between the degree of hydrops on the one hand and the averaged hearing level at 0.25-1 and 0.5-3 kHz and the vestibular evoked myogenic potential interaural amplitude ratio on the other hand. A trend toward a correlation was noticed between the hydrops and the caloric response, no correlation was noticed between the hydrops and the SP/AP ratio. The degree of endolymphatic hydrops correlates with a progressive loss of auditory and sacculus function in patients with Meniere`s disease.
authors: Department of Otorhinolaryngology Head and Neck Surgery, Grosshadern Medical Centre, University of Munich, Marchioninistrasse 15, Munich, Germany. rguerkov@med.uni-muenchen.de
authors: Robert
authors: R
authors: Gürkov
authors: Wilhem
authors: W
authors: Flatz
authors: Julia
authors: J
authors: Louza
authors: Michael
authors: M
authors: Strupp
authors: Eike
authors: E
authors: Krause
mesh_terms: D000328:Adult; D000368:Aged; D001300:Audiometry, Evoked Response / Q000379:methods*; D001309:Auditory Threshold; D003051:Cochlea / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D018159:Endolymphatic Hydrops / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged; D011446:Prospective Studies; D058585:Vestibular Evoked Myogenic Potentials; D055815:Young Adult