title: Diphenyl diselenide induces anxiolytic-like and sedative effects on the chick social separation-stress behavior.
abstract: The purpose of this research was to investigate the anxiolytic-like effect of diphenyl diselenide [(PhSe)(2)] on the chick social separation-stress behavior. Male chicks (six day-old) received, per oral route, a single administration of (PhSe)(2) at doses of 1, 10 and 50mg/kg. Thirty minutes after treatment, chicks were submitted to the behavioral tests. The behavioral tests: number of separation-induced distress vocalizations and jumps, time of active wakefulness, time of standing/sitting motionless with eyes open, time of standing motionless with eyes closed and time of sleeping posture, during 10 min, were recorded. (PhSe)(2) at doses of 10 and 50mg/kg reduced the number of vocalizations and jumps and the time of active wakefulness and increased the time of standing/sitting motionless with eyes open of chicks. The sleeping posture time was increased in animals treated with (PhSe)(2) at the dose of 50mg/kg. In conclusion, treatment with (PhSe)(2), in a dose dependent-manner, caused anxiolytic-like and sedative effects in chicks.
authors: Programa de Pós-graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil. marinaprigol@yahoo.com.br
authors: Marina
authors: M
authors: Prigol
authors: Cristiane
authors: C
authors: Luchese
authors: Simone
authors: S
authors: Pinton
authors: Marlise
authors: M
authors: Ferreira
authors: João Paulo Aquino
authors: JP
authors: Santos
authors: Ana Kátia
authors: AK
authors: Karkow
authors: Antonio Carlos
authors: AC
authors: Mortari
authors: Cristina Wayne
authors: CW
authors: Nogueira
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D001555:Benzene Derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D006993:Hypnotics and Sedatives / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D016566:Organoselenium Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D012934:Social Isolation; D013315:Stress, Psychological / Q000517:prevention & control* / Q000523:psychology
chemical_list: D014151:Anti-Anxiety Agents; D001555:Benzene Derivatives; D006993:Hypnotics and Sedatives; D016566:Organoselenium Compounds; C061132:diphenyldiselenide