title: Rational design of a Tn antigen mimic.
abstract: A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.
authors: Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, UA-CSIC, Madre de Dios, 51, 26006 Logroño, Spain. francisco.corzana@unirioja.es
authors: Francisco
authors: F
authors: Corzana
authors: Jesús H
authors: JH
authors: Busto
authors: Filipa
authors: F
authors: Marcelo
authors: Marisa García
authors: MG
authors: de Luis
authors: Juan L
authors: JL
authors: Asensio
authors: Sonsoles
authors: S
authors: Martín-Santamaría
authors: Yolanda
authors: Y
authors: Sáenz
authors: Carmen
authors: C
authors: Torres
authors: Jesús
authors: J
authors: Jiménez-Barbero
authors: Alberto
authors: A
authors: Avenoza
authors: Jesús M
authors: JM
authors: Peregrina
mesh_terms: D000818:Animals; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry* / Q000276:immunology*; D006020:Glycopeptides / Q000737:chemistry / Q000378:metabolism; D037102:Lectins / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D015394:Molecular Structure; D018396:Mucin-1 / Q000737:chemistry*; D012694:Serine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D006020:Glycopeptides; D037102:Lectins; D018396:Mucin-1; C040286:Tn antigen; C035563:2-methylserine; D012694:Serine