title: [Therapeutic angiogenesis using gene transfer and stem cell therapy in peripheral artery disease].
abstract: The world-wide largest angiogenesis gene therapy trial in 525 patients suffering from critical limb ischemia and treated with the non-viral gene construct for fibroblast growth factor (NV1FGF) or placebo was negative for all endpoints. Also, stem cell or progenitor cell therapy did no reveal clinical benefit in patients with peripheral artery disease. Data from large randomized placebo-controlled are still not available.
authors: Chefärztin Klinische und Interventionelle Angiologie, Asklepios Klinik St.Georg, Lohmühlenstr. 5, 20099 Hamburg. s.nikol@asklepios.com
authors: S
authors: S
authors: Nikol
mesh_terms: D000671:Amputation, Surgical; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D018849:Controlled Clinical Trials as Topic; D016220:Fibroblast Growth Factor 1 / Q000235:genetics*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007383:Intermittent Claudication / Q000235:genetics / Q000401:mortality / Q000628:therapy; D007511:Ischemia / Q000235:genetics / Q000401:mortality / Q000628:therapy; D007866:Leg / Q000098:blood supply; D018919:Neovascularization, Physiologic / Q000235:genetics*; D010865:Pilot Projects; D016032:Randomized Controlled Trials as Topic; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology; D017211:Treatment Failure
chemical_list: D016220:Fibroblast Growth Factor 1