title: [Morphological analysis of bone dynamics and metabolic bone disease. Pathophisiology of Microdamage].
abstract: Microdamage, small crack in bone, is a product of bone fatigue. Burden of microdamage in vivo bone is determined by balance of generation and repair of microdamage. It has been reported that aging, bone loss, coarse osteocyte network, reduced bone remodeling cause accumulation of microdamage in bone. It is suspected that insufficiency fractures of subtrochanteric femur in patients under long term bisphophonate treatment are caused by severely suppressed bone turnover.
authors: Bone and Joint Surgery, Seirei Hamamatsu General Hospital.
authors: Satoshi
authors: S
authors: Mori
mesh_terms: D000375:Aging / Q000473:pathology; D050071:Bone Density Conservation Agents / Q000009:adverse effects; D016723:Bone Remodeling / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology* / Q000502:physiology; D004164:Diphosphonates / Q000009:adverse effects; D005264:Femoral Fractures / Q000209:etiology / Q000473:pathology; D015775:Fractures, Stress / Q000209:etiology / Q000473:pathology*; D006801:Humans; D010011:Osteocytes / Q000473:pathology; D010024:Osteoporosis / Q000473:pathology
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates