title: HVRII of mtDNA in cord blood cells of newborn children and in their saliva 10 years later.
abstract: Comparison of hypervariable region II nucleotide sequences of mitochondrial DNA obtained from cord blood cells and saliva cells of the same individual at birth and after ten years revealed a few differences at the so-called mutation hot spots (three transitions and three indels within the C-tract). The personal identity of samples was proved by short tandem repeat profiling. Comparison of individuals living in two regions that differ by air pollution, however, did not reveal statistically significantly increased number of mutations in the population from the region of poorer environmental conditions, although indicating such tendency.
authors: Department of Developmental Genotoxicology, Institute of Experimental Medicine AS CR, Prague, Czech Republic.
authors: J
authors: J
authors: Schmuczerová
authors: P
authors: P
authors: Töröková
authors: M
authors: M
authors: Kujanová
authors: H
authors: H
authors: Cechová
authors: J
authors: J
authors: Topinka
authors: M
authors: M
authors: Dostál
authors: R J
authors: RJ
authors: Sram
authors: R
authors: R
authors: Brdička
mesh_terms: D000397:Air Pollution; D002648:Child; D018153:Czech Republic; D004272:DNA, Mitochondrial / Q000032:analysis / Q000097:blood / Q000235:genetics*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011110:Polymorphism, Genetic; D012463:Saliva / Q000737:chemistry*
chemical_list: D004272:DNA, Mitochondrial