title: Pancreatic endocrine tumors.
abstract: The endocrine cells of the pancreas and their related cells throughout the gastrointestinal tract give rise to a variety of tumors that pose a diagnostic challenge. There has been progress in understanding their histogenesis, morphology, immunohistochemistry, molecular biology and classifications. This review will focus on nomenclature/terminology, classification, the role of immunohistochemistry, molecular advances, including genetic predisposition, and potential therapeutic targets to define the role of pathology in the application of prognostic and predictive markers for this disease.
authors: Department of Pathology and Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, ON, Canada. sylvia.asa@uhn.on.ca
authors: Sylvia L
authors: SL
authors: Asa
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D017481:Receptors, Somatostatin / Q000378:metabolism; D009626:Terminology as Topic
chemical_list: D014408:Biomarkers, Tumor; D017481:Receptors, Somatostatin