title: Triggering receptor expressed on myeloid cell 1.
abstract: Sepsis is a common cause of morbidity and mortality in intensive care units. There is no gold standard for diagnosing sepsis because clinical and laboratory signs are neither sensitive nor specific enough and microbiological studies often show negative results. The triggering receptor expressed on myeloid cell 1 (TREM-1) is a member of the immunoglobulin superfamily. Its expression is upregulated on phagocytic cells in the presence of bacteria or fungi. This article reports on the potential usefulness of the assessment of the soluble form of TREM-1 in biologic fluids in the diagnosis of infection.
authors: Medical ICU, University Hospital of Nancy, Avenue de Lattre de Tassigny, 54000 Nancy, France.
authors: Damien
authors: D
authors: Barraud
authors: Sébastien
authors: S
authors: Gibot
mesh_terms: D000818:Animals; D001168:Arthritis / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D016638:Critical Illness; D003937:Diagnosis, Differential; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D009000:Monocytes / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D010195:Pancreatitis / Q000378:metabolism; D010538:Peritonitis / Q000378:metabolism; D010996:Pleural Effusion / Q000378:metabolism; D011014:Pneumonia / Q000378:metabolism; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism* / Q000502:physiology; D018805:Sepsis / Q000175:diagnosis* / Q000378:metabolism*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D014552:Urinary Tract Infections / Q000378:metabolism; D014657:Vasculitis / Q000097:blood
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1