title: A systems biology approach to the evolution of plant-virus interactions.
abstract: Omic approaches to the analysis of plant-virus interactions are becoming increasingly popular. These types of data, in combination with models of interaction networks, will aid in revealing not only host components that are important for the virus life cycle, but also general patterns about the way in which different viruses manipulate host regulation of gene expression for their own benefit and possible mechanisms by which viruses evade host defenses. Here, we review studies identifying host genes regulated by viruses and discuss how these genes integrate in host regulatory and interaction networks, with a particular focus on the physical properties of these networks.
authors: Instituto de Biología Molecular y Celular de Plantas, CSIC-UPV, Ingeniero Fausto Elio s/n, 46022 València, Spain. sfelena@ibmcp.upv.es
authors: Santiago F
authors: SF
authors: Elena
authors: Javier
authors: J
authors: Carrera
authors: Guillermo
authors: G
authors: Rodrigo
mesh_terms: D019143:Evolution, Molecular; D018506:Gene Expression Regulation, Plant; D015967:Gene Expression Regulation, Viral; D053263:Gene Regulatory Networks; D054884:Host-Pathogen Interactions; D010935:Plant Diseases / Q000235:genetics / Q000821:virology; D010940:Plant Proteins / Q000378:metabolism; D010942:Plant Viruses / Q000235:genetics / Q000472:pathogenicity*; D010944:Plants / Q000235:genetics / Q000378:metabolism / Q000821:virology*; D012641:Selection, Genetic; D049490:Systems Biology; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D010940:Plant Proteins; D014157:Transcription Factors