title: Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis.
abstract: BACKGROUND
  Obesity is recently known as a risk factor for endoscopic gastritis. Adiponectin is an anti-inflammatory cytokine secreted from fat tissue, and its serum concentrations are reduced in obesity. The relation between adiponectin and gastritis remains unclear.
  
  
  OBJECTIVE
  The aim of this study was to determine whether lower serum adiponectin level is associated with the risk of endoscopic gastritis.
  
  
  METHODS
  We analyzed medical records of participants of a routine health check-up examination. Association among endoscopic findings, serum adiponectin level, and other clinical factors including age, sex, alcohol habit, smoking habit, body mass index (BMI), blood pressure, cholesterol, triglyceride, glucose, and insulin were investigated. Endoscopic erosive gastritis was defined as a flat or minimally depressed white spot surrounded by a reddish area or small elevation with central umbilications mimicking octopus' suckers.
  
  
  RESULTS
  A total of 2,400 participants were enrolled. BMI was significantly higher in gastritis-positive participants than in gastritis-negative participants. Serum adiponectin levels were significantly lower in gastritis-positive participants than in gastritis-negative participants. Multivariate logistic regression analysis revealed that lower serum adiponectin level (OR 0.96; 95% CI 0.93-0.99), smoking (OR 0.50; 95% CI 0.30-0.80), higher blood pressure (OR 1.02; 95% CI 1.01-1.03), and duodenitis (OR 1.8; 95% CI 1.00-3.09) were significantly associated with endoscopic erosive gastritis.
  
  
  CONCLUSIONS
  Lower serum level of adiponectin may increase the risk of endoscopic erosive gastritis, independently of BMI. Our findings facilitate further study to clarify the role of hypoadiponectinemia in erosive gastritis.
authors: Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, and Sumitomo Hospital, Osaka, Japan.
authors: Shunsuke
authors: S
authors: Yamamoto
authors: Kenji
authors: K
authors: Watabe
authors: Shusaku
authors: S
authors: Tsutsui
authors: Shinichi
authors: S
authors: Kiso
authors: Toshimitsu
authors: T
authors: Hamasaki
authors: Motohiko
authors: M
authors: Kato
authors: Yoshihiro
authors: Y
authors: Kamada
authors: Yuichi
authors: Y
authors: Yoshida
authors: Shinji
authors: S
authors: Kihara
authors: Miyuki
authors: M
authors: Umeda
authors: Aiko
authors: A
authors: Furubayashi
authors: Kazuo
authors: K
authors: Kinoshita
authors: Osamu
authors: O
authors: Kishida
authors: Takashi
authors: T
authors: Fujimoto
authors: Akira
authors: A
authors: Yamada
authors: Yoshifumi
authors: Y
authors: Tsukamoto
authors: Norio
authors: N
authors: Hayashi
authors: Yuji
authors: Y
authors: Matsuzawa
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000097:blood / Q000453:epidemiology; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005260:Female; D005756:Gastritis / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D012189:Retrospective Studies; D012306:Risk; D012907:Smoking / Q000097:blood / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol