title: p53 codon 72 polymorphism and liver cancer susceptibility: a meta-analysis of epidemiologic studies.
abstract: OBJECTIVE
  To evaluate the association between p53 codon 72 polymorphism and liver cancer risk by means of meta-analysis.
  
  
  METHODS
  Two investigators independently searched the Medline, Embase and Chinese Biomedicine databases. Summary odds ratios and 95% CI for p53 codon 72 polymorphism and liver cancer were calculated in fixed-effects model (Mantel-Haenszel method) and random-effects model (DerSimonian and Laird method) when appropriate.
  
  
  RESULTS
  This meta-analysis included 1115 liver cancer cases and 1778 controls. The combined results based on all studies showed that there was a statistically significant link between Pro/Pro genotype and liver cancer, but not between Arg/Arg or Pro/Arg genotype and liver cancer. When stratifying for race, similar results were obtained, i.e. patients with liver cancer had a significantly higher frequency of Pro/Pro genotype than non-cancer patients among Asians. After stratifying the various studies by control source, gender, family history of liver cancer and chronic hepatitis virus infection, we found that (1) patients among hospital-based studies had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer; (2) female patients with liver cancer had a significantly lower frequency of Arg/Arg and a higher frequency of Pro/Arg+Pro/Pro genotypes than female individuals without cancer; (3) subgroup analyses for family history of liver cancer did not reveal any significant association between p53 codon 72 polymorphism and liver cancer development; and (4) patients with negative hepatitis virus infection had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the p53 codon 72 polymorphism may be associated with liver cancer among Asians.
authors: Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, 37 Guo Xue Road, Chengdu 610041, Sichuan Province, China.
authors: Xi
authors: X
authors: Chen
authors: Fei
authors: F
authors: Liu
authors: Bo
authors: B
authors: Li
authors: Yong-Gang
authors: YG
authors: Wei
authors: Lv-Nan
authors: LN
authors: Yan
authors: Tian-Fu
authors: TF
authors: Wen
mesh_terms: D044466:Asian People / Q000235:genetics; D003062:Codon; D016208:Databases, Factual; D016021:Epidemiologic Studies; D005260:Female; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53