title: TOMM40 poly-T variants and cerebrospinal fluid amyloid beta levels in the elderly.
abstract: A variable poly-T polymorphism in the TOMM40 gene, which is in linkage disequilibrium with APOE, was recently implicated with increased risk and earlier onset age for late-onset Alzheimer's disease in APOE ε3 carriers. To elucidate potential neurobiological mechanisms underlying this association, we compared the effect of TOMM40 poly-T variants to the effect of APOE, an established LOAD-risk modulator, on cerebrospinal fluid (CSF) amyloid beta (Aβ) and tau levels, in cognitively intact elderly subjects. APOE ε4 carriers showed significant reductions in Aβ 1-42 levels compared to non-ε4 carriers, but no differences were detected across TOMM40 variants. Neither Aβ 1-40 nor tau levels were affected by APOE or TOMM40.
authors: Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Bldg 35, Orangeburg, NY 10962, USA. Pomara@nki.rfmh.org
authors: Nunzio
authors: N
authors: Pomara
authors: Davide
authors: D
authors: Bruno
authors: Jay J
authors: JJ
authors: Nierenberg
authors: John J
authors: JJ
authors: Sidtis
authors: Frank T
authors: FT
authors: Martiniuk
authors: Pankaj D
authors: PD
authors: Mehta
authors: Henrik
authors: H
authors: Zetterberg
authors: Kaj
authors: K
authors: Blennow
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid / Q000378:metabolism*; D006801:Humans; D026901:Membrane Transport Proteins / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000090622:Mitochondrial Precursor Protein Import Complex Proteins
chemical_list: D016229:Amyloid beta-Peptides; D026901:Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; C400783:TOMM40 protein, human