title: ["Herpetic keratitis". Various expressions require different therapeutic approaches].
abstract: Herpes simplex virus (HSV) is a common cause of keratitis. "Herpetic keratitis" is a chameleon, which is well treatable today if the various types of clinical expression of this disease are known to the ophthalmologist and treatment is adjusted accordingly. Types of expression include 1. epithelial keratitis (dendritica/geographica), 2. stromal keratitis (necrotizing vs. non-necrotizing = "interstitial keratitis"), 3. endotheliitis (=disciform keratitis), 4. neurotrophic keratopathy (=so-called metaherpetic keratitis) and 5. (vascularized) corneal scars. A concomitant ocular hypertension should be treated predominantly non-surgically (no prostaglandin analogues). Topical artificial tears (if necessary with acyclovir ointment at night) in the quiet interval are recommended to limit the tendency towards recurrences. After keratoplasty and in cases of severe recurrences of herpetic keratitis, systemic acyclovir application (2×400 mg/day) for at least 1 year is indispensable! Overall, HSV has lost its "terror" today, even after keratoplasty, given adequate management.
authors: Klinik für Augenheilkunde und Hochschulambulanz, Universitätsklinikum des Saarlandes UKS, Kirrbergerstr. 1, 66424, Homburg/Saar, Deutschland. berthold.seitz@uks.eu
authors: B
authors: B
authors: Seitz
authors: A
authors: A
authors: Heiligenhaus
mesh_terms: D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000998:Antiviral Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D016039:Corneal Transplantation; D003937:Diagnosis, Differential; D006801:Humans; D007635:Keratitis, Dendritic / Q000145:classification / Q000175:diagnosis / Q000628:therapy; D016849:Keratitis, Herpetic / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D009184:Mydriatics / Q000008:administration & dosage; D009883:Ophthalmic Solutions; D012008:Recurrence
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D009184:Mydriatics; D009883:Ophthalmic Solutions