title: Wound healing in diabetes: hemorheological and microcirculatory aspects.
abstract: Diabetes is associated with many hemorheological alterations. The decrease of RBC deformability, increase of aggregability, vasoconstriction, increase of blood viscosity and decrease of oxygen supply have a significant effect on wound healing, such as in foot ulcers. Basically, there is endothelial dysfunction and alteration of permeability; these impair wound healing in diabetic patients. Microcirculation still functions and there is blood flow, even when there is a decrease in vessel diameter, without anatomical lesions in vessel walls. It is necessary to maintain a good oxygen supply. Analyzing microcirculation and hemorheology in diabetes and considering methodologies to treat diabetic foot ulcers (e.g., hyperbaric oxygen therapy, laser, and vacuum) may help in the treatment of patient pathologies.
authors: Hemorheology and Microcirculation Research Unit, University of Bari, Bari, Italy. gcicco.emo@tiscali.it
authors: Giuseppe
authors: G
authors: Cicco
authors: Francesco
authors: F
authors: Giorgino
authors: Sebastiano
authors: S
authors: Cicco
mesh_terms: D003920:Diabetes Mellitus / Q000628:therapy*; D017719:Diabetic Foot / Q000503:physiopathology / Q000628:therapy*; D018056:Hemorheology; D006801:Humans; D006931:Hyperbaric Oxygenation; D008833:Microcirculation; D014945:Wound Healing