title: S100A8 cellular distribution in normal epithelium, hyperplasia, dysplasia and squamous cell carcinoma and its concentration in serum.
abstract: OBJECTIVE
  To investigate the function of S100A8, a member of the calcium-binding S100 protein family, in oral tumorigenesis. We analyzed its cellular distribution and its serum level in patients with squamous cell carcinoma and normal controls.
  
  
  METHODS
  We investigated the histopathologic features by tissue microarrays (TMAs) including 8 normal, 66 hyperplastic and dysplastic and 26 oral squamous cell carcinoma (OSCC) tissue cores. The serum level of S100A8 was measured by an enzyme-linked immunosorbent assay using 33 healthy volunteers, 20 patients with hyperproliferative lesions and 23 patients with OSCC.
  
  
  RESULTS
  The TMA analysis resulted in different findings. The strongest expression of S100A8 was found in severe dysplasias and carcinoma in situ. In tumor tissue an increased expression occurred only focally. In the normal tissue cores the epithelium showed a moderate reaction, but basal and parabasal cells were completely negative. The serum levels of S100A8 were marginally reduced in cancer patients. The expression between healthy controls and patients with hyperproliferative lesions displayed no difference.
  
  
  CONCLUSIONS
  The expression of S100A8 is helpful only in the transition from severe dysplastic tissue to cancer.
authors: Department of Oral and Maxillofacial Surgery, University of Regensburg, Regensburg, Germany.
authors: Oliver
authors: O
authors: Driemel
authors: Niko
authors: N
authors: Escher
authors: Günther
authors: G
authors: Ernst
authors: Christian
authors: C
authors: Melle
authors: Ferdinand
authors: F
authors: von Eggeling
mesh_terms: D020013:Calcium Signaling / Q000502:physiology; D040501:Calgranulin A / Q000097:blood* / Q000502:physiology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D004848:Epithelium / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D016612:Paraffin Embedding
chemical_list: D040501:Calgranulin A