title: Estrogen receptor of breast cancer stem cells depending on the original breast cancers.
abstract: There has been arguments about the estrogen receptor-α (from this point referred to as ER) of breast cancer stem cells (BrCSCs). Most investigations support the proposition that BrCSCs are ER(-), whereas some other studies indicate that BrCSCs are ER(+). We concluded that the ER expression of BrCSCs in ER(+) breast cancers is positive, while it is negative in ER(-) breast cancers. Therefore, we hypothesize that the ER expression of BrCSCs depends on the original breast cancers. It may provide a novel strategy for the therapy targeting BrCSCs.
authors: Oncology Department, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China. xuweiru1983@163.com
authors: Wei-Ru
authors: WR
authors: Xu
authors: Hong-Sheng
authors: HS
authors: Lin
authors: Xin-Yi
authors: XY
authors: Chen
authors: Ying
authors: Y
authors: Zhang
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000502:physiology*
chemical_list: D011960:Receptors, Estrogen