title: Role of advanced oxidation protein products and Thiol ratio in patients with acute coronary syndromes.
abstract: OBJECTIVE
  To identify systemically detectable vascular inflammation associated to redox system unbalance, advanced oxidation protein products (AOPP), formed by HClO reaction with proteins, Thiol levels, and their ratio (AOPP/Thiol ratio) were measured in patients with acute coronary syndromes (ACS).
  
  
  METHODS
  We evaluated AOPP/Thiol ratio together with CRP and IL-1β in 18 acute myocardial infarction (AMI) and in 16 unstable angina (UA) patients at admission, and in 16 control subjects (CTR); the measurements were repeated at 1 and at 6 months.
  
  
  RESULTS
  At admission, AMI and UA patients displayed higher AOPP/Thiol ratio and CRP and IL-1β compared to CTR subjects. A correlation between AOPP/Thiols and IL-1β in AMI was found. At follow-up, in UA only, AOPP/Thiol ratio and IL-1β levels still remained high.
  
  
  CONCLUSIONS
  The AOPP/Thiol ratio seems to affect the inflammatory process in ACS, and may represent a reliable marker of oxidative unbalance in this setting of patients.
authors: Re-infarction Prevention Center, Department of Internal Medicine, University of Genova, Genova, Italy.
authors: Antonio
authors: A
authors: Barsotti
authors: Patrizia
authors: P
authors: Fabbi
authors: Massimiliano
authors: M
authors: Fedele
authors: Silvano
authors: S
authors: Garibaldi
authors: Manrico
authors: M
authors: Balbi
authors: Gian Paolo
authors: GP
authors: Bezante
authors: Domenico
authors: D
authors: Risso
authors: Francesco
authors: F
authors: Indiveri
authors: Giorgio
authors: G
authors: Ghigliotti
authors: Claudio
authors: C
authors: Brunelli
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D000789:Angina, Unstable / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D001798:Blood Proteins; D008076:Cholesterol, HDL; D053583:Interleukin-1beta; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol