title: [Determination of gabapentin using capillary electrophoresis with laser-induced fluorescence detection].
abstract: A novel method for the determination of gabapentin (an antiepileptic drug) has been developed using capillary electrophoresis with laser-induced fluorescence detection (LIFD). Gabapentin was first derived by 4-chloro-7-nitrobenzofurazan (NBD-Cl) and baseline separated within 6 min with a running buffer consisting of 10 mmol/L borate sodium and 10 mmol/L sodium dodecyl sulfate (pH 9.75). The linear range of this method was 0.01-10 mg/L (r = 0.9997) with the limit of detection (LOD) of 2 microg/L and the limit of quantification (LOQ) of 10 microg/L. The average recoveries were 100.2%-103.1% with the relative standard deviation (RSD) of 0.15%-1.00%. This method is fast, sensitive, accurate and reliable, and it has been used successfully for the quality assessment of gabapentin drug products.
authors: College of Chemical Engineering, Sichuan University, Chengdu 610065, China.
authors: Yuanli
authors: Y
authors: Cai
authors: Jiajia
authors: J
authors: Yang
authors: Yufei
authors: Y
authors: Wang
authors: Keke
authors: K
authors: Bai
authors: Hui
authors: H
authors: Li
mesh_terms: D000588:Amines / Q000032:analysis*; D000927:Anticonvulsants / Q000032:analysis*; D003509:Cyclohexanecarboxylic Acids / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D000077206:Gabapentin; D007834:Lasers; D013050:Spectrometry, Fluorescence / Q000379:methods*; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
chemical_list: D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin