title: Platelet-rich plasma plus bioactive glass in the treatment of intra-bony defects: a study in dogs.
abstract: OBJECTIVE
  This study was designed to evaluate, histomorphometrically, the association of platelet-rich plasma (PRP) and bioactive glass (BG) in the treatment of periodontal intrabony defects.
  
  
  METHODS
  Nine mongrel dogs were included in the study. Three-wall intrabony defects were surgically created at the mesial and distal aspect of first mandibular molar and exposed to plaque accumulation for 1 month. The defects were randomly assigned to the groups: control, BG, PRP, PRP+BG. Dogs were sacrificed 90 days after the surgeries. The histometric parameters evaluated were: length of sulcular and junctional epithelium, connective tissue adaptation, new cementum, new bone, defect extension and area of new bone filling the defect.
  
  
  RESULTS
  A superior area of new bone was observed in PRP+BG and BG (13.80 ± 2.32 mm² and 15.63 ± 2.64 mm², respectively) when compared to the other groups (8.19 ± 1.46 mm² and 8.81 ± 1.47 mm² for control and PRP, respectively). No statistically significant differences were observed in the remaining parameters.
  
  
  CONCLUSIONS
  Within the limits of this study, it may be concluded that PRP failed to provide statistically significant improvements in the histometric parameters.
authors: Division of Periodontics, Department of Prosthodontics and Periodontics, Dental School of Manaus, State University of Amazonas, Manaus, AM, Brazil.
authors: Marcelo Diniz
authors: MD
authors: Carvalho
authors: Fabrícia Ferreira
authors: FF
authors: Suaid
authors: Mauro Pedrine
authors: MP
authors: Santamaria
authors: Marcio Zaffalon
authors: MZ
authors: Casati
authors: Francisco Humberto
authors: FH
authors: Nociti
authors: Antonio Wilson
authors: AW
authors: Sallum
authors: Enilson Antônio
authors: EA
authors: Sallum
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002516:Ceramics / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004285:Dogs; D005260:Female; D023421:Models, Animal; D010510:Periodontal Diseases / Q000601:surgery; D053657:Platelet-Rich Plasma; D011897:Random Allocation; D014945:Wound Healing
chemical_list: C022107:Bioglass; D018786:Bone Substitutes