title: A metapopulation model for malaria with transmission-blocking partial immunity in hosts.
abstract: A metapopulation malaria model is proposed using SI and SIRS models for the vectors and hosts, respectively. Recovered hosts are partially immune to the disease and while they cannot directly become infectious again, they can still transmit the parasite to vectors. The basic reproduction number [Formula: see text] is shown to govern the local stability of the disease free equilibrium but not the global behavior of the system because of the potential occurrence of a backward bifurcation. Using type reproduction numbers, we identify the reservoirs of infection and evaluate the effect of control measures. Applications to the spread to non-endemic areas and the interaction between rural and urban areas are given.
authors: Department of Mathematics, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada. arinoj@cc.umanitoba.ca
authors: Julien
authors: J
authors: Arino
authors: Arnaud
authors: A
authors: Ducrot
authors: Pascal
authors: P
authors: Zongo
mesh_terms: D000818:Animals; D000852:Anopheles; D058872:Epidemics / Q000706:statistics & numerical data; D006801:Humans; D007303:Insect Vectors / Q000276:immunology; D008288:Malaria / Q000453:epidemiology / Q000276:immunology / Q000635:transmission*; D008297:Male; D008954:Models, Biological; D011157:Population Dynamics