title: An approach to the core structure of leiodermatolide.
abstract: The synthesis of the 16-membered core structure of leiodermatolide 40 has been achieved in 26 linear steps starting from (R)-Roche ester. The key steps in the synthesis of 40 are a Stille cross-coupling between two main fragments 11 and 33 having roughly equal size. For the trisubstituted C4/C5 double bond a carbometalation reaction followed by a Suzuki coupling was used. A Yamaguchi macrolactonization furnished macrolactone 39.
authors: Institut für Organische Chemie, Universität Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Gemany.
authors: Christian
authors: C
authors: Rink
authors: Vaidotas
authors: V
authors: Navickas
authors: Martin E
authors: ME
authors: Maier
mesh_terms: D018942:Macrolides / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D018942:Macrolides; C559222:leiodermatolide