title: Mechanism of glutaredoxin-ISU [2Fe-2S] cluster exchange.
abstract: Exchange of [2Fe-2S] centers between Grx2 and the cluster scaffold protein ISU, and characterization of two mutually exclusive Grx2 binding sites on ISU by isothermal titration calorimetry supports a direct link for Grx and glutathione involvement in ISU promoted Fe-S cluster biosynthesis.
authors: Ohio State Biochemistry Program, The Ohio State University, 100 West 18thAvenue, Columbus, OH 43210, USA.
authors: Wenbin
authors: W
authors: Qi
authors: J A
authors: JA
authors: Cowan
mesh_terms: D001665:Binding Sites; D002152:Calorimetry, Differential Scanning; D054477:Glutaredoxins / Q000378:metabolism*; D019803:Glutathione Disulfide / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000378:metabolism*; D007700:Kinetics; D013455:Sulfur / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: C516008:GLRX2 protein, human; D054477:Glutaredoxins; C506160:ISCU protein, human; D007506:Iron-Sulfur Proteins; D013455:Sulfur; D007501:Iron; D019803:Glutathione Disulfide