title: Severe immune haemolytic anaemia due to ceftriaxone in a patient with congenital nephrotic syndrome.
abstract: OBJECTIVE
  To describe the first case of ceftriaxone-related haemolysis in a patient with congenital nephrotic syndrome (CNS).
  
  
  BACKGROUND
  Severe haemolysis caused by an immune reaction to ceftriaxone has mostly been described in patients with underlying haematological or immune dysfunction.
  
  
  METHODS
  The authors present a 20-month-old boy with CNS of the Finnish type with several previous severe infections treated with ceftriaxone, admitted for suspected sepsis. Following ceftriaxone administration he developed shock secondary to an acute haemolytic reaction, with severe anaemia. Hypersensitivity to ceftriaxone was documented through positive agglutination tests.
  
  
  CONCLUSIONS
  Onset of haemolysis following ceftriaxone administration, particularly in a patient previously exposed to the drug, must raise the suspicion of a possible immune reaction.
authors: Unidade de Nefrologia Pediátrica, Departamento da Criança e da Família, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal. boto.leonor@gmail.com
authors: Maria Leonor
authors: ML
authors: Reis Boto
authors: Ana Rita
authors: AR
authors: Sandes
authors: Anabela
authors: A
authors: Brites
authors: Susana
authors: S
authors: Silva
authors: Rosário
authors: R
authors: Stone
authors: Margarida
authors: M
authors: Almeida
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000175:diagnosis; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002443:Ceftriaxone / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications*; D018805:Sepsis / Q000150:complications / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone