title: New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity--Part II.
abstract: Following our search for antimalarial compounds, novel series of ferrocenyl-substituted pyrrolo[1,2-a]quinoxalines 1-2 were synthesized from ferrocene-carboxaldehyde and tested for their in vitro activity upon the erythrocytic development of Plasmodium falciparum strains with different chloroquine-resistance status. The ferrocenic pyrrolo[1,2-a]quinoxalines 1-2 were prepared in 6 or 9 steps through a Barton-Zard reaction. Promising pharmacological results against FcB1, K1 and F32 strains were obtained with ferrocenyl pyrrolo[1,2-a]quinoxalines 1j-l linked by a bis-(3-aminopropyl)piperazine linker substituted by a nitrobenzyl moiety.
authors: Université Bordeaux Segalen, Pharmacochimie, CNRS, Pharmacochimie, FRE 3396, F-33000 Bordeaux, France. jean.guillon@u-bordeaux2.fr
authors: Jean
authors: J
authors: Guillon
authors: Elisabeth
authors: E
authors: Mouray
authors: Stéphane
authors: S
authors: Moreau
authors: Catherine
authors: C
authors: Mullié
authors: Isabelle
authors: I
authors: Forfar
authors: Vanessa
authors: V
authors: Desplat
authors: Solene
authors: S
authors: Belisle-Fabre
authors: Noël
authors: N
authors: Pinaud
authors: François
authors: F
authors: Ravanello
authors: Augustin
authors: A
authors: Le-Naour
authors: Jean-Michel
authors: JM
authors: Léger
authors: Grace
authors: G
authors: Gosmann
authors: Christian
authors: C
authors: Jarry
authors: Gérard
authors: G
authors: Déléris
authors: Pascal
authors: P
authors: Sonnet
authors: Philippe
authors: P
authors: Grellier
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005296:Ferrous Compounds / Q000737:chemistry*; D006801:Humans; D000075163:Metallocenes; D008958:Models, Molecular; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D005296:Ferrous Compounds; D000075163:Metallocenes; D011758:Pyrroles; D011810:Quinoxalines; C531444:pyrrolo(1,2-a)quinoxaline; C004998:ferrocene