title: New insights into the pathogenesis of cellular crescents.
abstract: OBJECTIVE
  This review discusses the recent evidence that intrinsic glomerular cells including podocytes, parietal epithelial cells and progenitor cells within Bowman's capsule contribute to cellular crescents.
  
  
  RESULTS
  Using a variety of newer molecular markers and lineage tracing experiments, investigators have clearly demonstrated that glomerular cells play a key role in the development and progression of cellular crescents in experimental and human disease.
  
  
  CONCLUSIONS
  Crescentic glomerulonephritis is associated with significant morbidity and mortality. Current therapies target the immune system. The recent finding that nonimmune cells also play a role in crescent formation highlights the need to identify alternate and complimentary therapeutic strategies.
authors: Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors: Sunita K S
authors: SK
authors: Singh
authors: Marie
authors: M
authors: Jeansson
authors: Susan E
authors: SE
authors: Quaggin
mesh_terms: D000818:Animals; D050476:Bowman Capsule / Q000473:pathology*; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007381:Intermediate Filament Proteins / Q000502:physiology; D051379:Mice; D009419:Nerve Tissue Proteins / Q000502:physiology; D064231:Nestin; D050199:Podocytes / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology
chemical_list: D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; C577485:Nes protein, mouse; D064231:Nestin