title: Chagas disease: increased parasitemia during pregnancy detected by hemoculture.
abstract: One hundred fifty-two Trypanosoma cruzi seropositive women were submitted to a single hemoculture; 101 were pregnant, and 51 were not pregnant. Seven tubes from each individual were harvested with liver infusion tryptose (LIT) medium and observed monthly until the fifth month. Hemocultures were positive in 50% (76 of 152) of the women. Results showed that the positivity was 29.4% (15 of 51) among non-pregnant women and 60.4% (61 of 101) in pregnant women (P < 0.05). In relation to gestational age, there were significant differences in positivity, with a higher proportion of women with positive hemocultures (20 of 25) before 21 weeks and lower after 30 weeks (10 of 21; P = 0.02). We conclude that pregnancy enhances the parasitemia in Chagas disease, with a higher effect early in pregnancy.
authors: Laboratório de Pesquisa da doença de Chagas, Hospital das Clínicas and Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Brazil.
authors: Liliane da Rocha
authors: Lda R
authors: Siriano
authors: Alejandro Ostermayer
authors: AO
authors: Luquetti
authors: Juliana Boaventura
authors: JB
authors: Avelar
authors: Neusa Leal
authors: NL
authors: Marra
authors: Ana Maria
authors: AM
authors: de Castro
mesh_terms: D000328:Adult; D001769:Blood / Q000469:parasitology; D014355:Chagas Disease / Q000097:blood* / Q000469:parasitology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D055815:Young Adult