title: Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II.
abstract: A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated.
authors: Department of Drug and Natural Product Synthesis, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
authors: Karem
authors: K
authors: Shanab
authors: Eva
authors: E
authors: Schirmer
authors: Eva
authors: E
authors: Wulz
authors: Barbara
authors: B
authors: Weissenbacher
authors: Sigrid
authors: S
authors: Lassnig
authors: Rita
authors: R
authors: Slanz
authors: Germana
authors: G
authors: Fösleitner
authors: Wolfgang
authors: W
authors: Holzer
authors: Helmut
authors: H
authors: Spreitzer
authors: Peter
authors: P
authors: Schmidt
authors: Babette
authors: B
authors: Aicher
authors: Gilbert
authors: G
authors: Müller
authors: Eckhard
authors: E
authors: Günther
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009285:Naphthoquinones; D011758:Pyrroles