title: Acute stroke intervention.
abstract: This review summarizes the current state-of-the-art regarding the endovascular management of acute ischemic stroke. Beginning with intravenous tissue plasminogen activator, this paper traces the gradual shift of systemic thrombolysis from a competing to complementary treatment modality. Intra-arterial thrombolysis, mechanical thrombectomy with the Merci (Concentric Medical, Mountain View, California) and Penumbra (Penumbra, Inc., Alameda, California) systems, angioplasty, primary intracranial stenting, and emerging stentriever devices are sequentially reviewed. Ultimately, this paper lays the foundation for current endovascular stroke management and considers future areas of progress and research.
authors: Department of Neurosurgery and Toshiba Stroke Research Center, University at Buffalo, State University of New York, USA.
authors: Alexander A
authors: AA
authors: Khalessi
authors: Sabareesh K
authors: SK
authors: Natarajan
authors: David
authors: D
authors: Orion
authors: Mandy J
authors: MJ
authors: Binning
authors: Adnan
authors: A
authors: Siddiqui
authors: Elad I
authors: EI
authors: Levy
authors: L Nelson
authors: LN
authors: Hopkins
mesh_terms: D017130:Angioplasty / Q000295:instrumentation; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation; D004867:Equipment Design; D006801:Humans; D018579:Patient Selection; D011474:Prosthesis Design; D018570:Risk Assessment; D012720:Severity of Illness Index; D015607:Stents; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D017131:Thrombectomy / Q000295:instrumentation; D015912:Thrombolytic Therapy; D013997:Time Factors; D016896:Treatment Outcome