title: Preoperative elevation of serum C-reactive protein as an independent prognostic indicator for gastric cancer.
abstract: OBJECTIVE
  Preoperative elevation of serum C-reactive protein (CRP) is a prognostic indicator for some malignant tumors. We investigated the clinicopathologic importance of an elevated preoperative serum CRP value in gastric carcinoma patients.
  
  
  METHODS
  We studied the relationship between the preoperative serum CRP value and clinicopathologic characteristics in 204 patients who underwent curative resection of gastric carcinoma.
  
  
  RESULTS
  The patients with preoperative CRP elevation had significantly poorer survival than those without CRP elevation (P < 0.0001). According to multivariate analysis, the factors independently associated with an unfavorable prognosis were a high preoperative CRP value (P = 0.024), lymphatic invasion (P = 0.017) and advanced tumor stage (P = 0.016).
  
  
  CONCLUSIONS
  Preoperative serum CRP elevation can be an independent prognostic indicator in patients with gastric carcinoma.
authors: Department of Surgery, Fukuoka Higashi Medical Center, 1-1-1 Chidori, Koga, 811-3195, Japan.
authors: Tadahiro
authors: T
authors: Nozoe
authors: Tomohiro
authors: T
authors: Iguchi
authors: Eisuke
authors: E
authors: Adachi
authors: Akito
authors: A
authors: Matsukuma
authors: Takahiro
authors: T
authors: Ezaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D018709:Statistics, Nonparametric; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein