title: Steroids and an oxylipin from an algicolous isolate of Aspergillus flavus.
abstract: A new oxylipin, (8E,12Z)-10,11-dihydroxyoctadeca-8,12-dienoic acid (1), a new steroid, 3β,4α-dihydroxy-26-methoxyergosta-7,24(28)-dien-6-one (2), and four known steroids, episterol (3), (22E,24R)-ergosta-7,22-dien-3β,5α,6α-triol (4), (22E,24R)-ergosta-5,22-dien-3β-ol (5), and (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (6), were isolated from the cultures of Aspergillus flavus, an endophytic fungus isolated from the marine red alga Corallina officinalis. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. 1 and 2 exhibited low activity to inhibit acetylcholinesterase and no activity against plant pathogenic fungi Colletotrichum lagenarium and Fusarium oxysporum.
authors: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors: Ming-Feng
authors: MF
authors: Qiao
authors: Nai-Yun
authors: NY
authors: Ji
authors: Feng-Ping
authors: FP
authors: Miao
authors: Xiu-Li
authors: XL
authors: Yin
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D001231:Aspergillus flavus / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D015394:Molecular Structure; D054883:Oxylipins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012015:Reference Standards; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D054883:Oxylipins; D013256:Steroids; D000110:Acetylcholinesterase