title: MALDI-TOF and MALDI-FTICR imaging mass spectrometry of methamphetamine incorporated into hair.
abstract: A new approach is described for imaging mass spectrometry (IMS) of methamphetamine (MA) incorporated into human hair using matrix-assisted laser desorption/ionization (MALDI)-time-of-flight (TOF) and MALDI-Fourier transform ion cyclotron resonance (FTICR). A longitudinal section of a lengthwise manually-cut single human hair shaft from a chronic MA user was directly analyzed by MALDI-TOF-IMS after deposited with α-Cyano-4-hydroxycinnamic acid matrix. A barcode-like image, which was most probably generated with repeated intakes of MA, was for the first time obtained by monitoring MA-specific product ion in the selected reaction monitoring mode. Laser beam scan lengthwise-cut hair shafts gave only poor mass spectra of MA, probably due to the loss of MA and/or the thermal denaturation of hair. The identity of MA detected in hair was further confirmed by MALDI-FTICR mass spectrometry. A combination with ultra-high resolution mass spectrometry by FTICR provided indisputable identification of MA. The MALDI-FTICR-IMS of another hair shaft from the same MA user also provided a barcode-like image by monitoring the protonated molecule of MA with ultra-high resolution. The two barcode-like images exhibited a close resemblance. Thus, MALDI-IMS can offer a new perspective: 'imaging hair analyses for drugs'.
authors: Forensic Science Laboratory, Osaka Prefectural Police Headquarters 1-3-18 Hommachi, Chuo-ward, Osaka 541-0053, Japan. miki.akihiro@gmail.com
authors: Akihiro
authors: A
authors: Miki
authors: Munehiro
authors: M
authors: Katagi
authors: Tooru
authors: T
authors: Kamata
authors: Kei
authors: K
authors: Zaitsu
authors: Michiaki
authors: M
authors: Tatsuno
authors: Toyofumi
authors: T
authors: Nakanishi
authors: Hitoshi
authors: H
authors: Tsuchihashi
authors: Takayuki
authors: T
authors: Takubo
authors: Koichi
authors: K
authors: Suzuki
mesh_terms: D006197:Hair / Q000737:chemistry*; D006801:Humans; D008694:Methamphetamine / Q000032:analysis*; D057054:Molecular Imaging; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D015813:Substance Abuse Detection
chemical_list: D008694:Methamphetamine