title: A heat-shock protein co-inducer treatment improves behavioral performance in rats exposed to hypoxia.
abstract: We investigated the effect of a heat-shock protein co-inducer, arimoclomol (CytRx, LA, CA), on hypoxia-adaptive responses using a rat model of simulated altitude exposure (hypobaric hypoxia).Cognitive function was measured using a T-maze and an object recognition test.Motor function was measured using an inclined-screen test and an adhesion removal test. Immunohistochemical analyses were assessed in brain for heat-shock protein 70 (HSP 70), intercellular adhesion molecule 1 (ICAM- 1) and apoptosis (TUNEL staining). Results show that both cognitive and motor performances were improved in rats treated with arimoclomol during hypoxic exposure; the hypoxia-induced expression of HSP70 and ICAM-1, and TUNEL-positive cells were reduced in brain with the treatment.Our data suggest that the arimoclomol treatment reduces the hypoxia-induced stress in brain tissue, and also improves the behavioral performance in rats during hypoxic adaptation.
authors: Department of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. kui.xu@case.edu
authors: Kui
authors: K
authors: Xu
authors: Xiaoyan
authors: X
authors: Sun
authors: Bernadette O
authors: BO
authors: Erokwu
authors: Ibolja
authors: I
authors: Cernak
authors: Joseph C
authors: JC
authors: Lamanna
mesh_terms: D000818:Animals; D017209:Apoptosis; D001522:Behavior, Animal; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism* / Q000473:pathology / Q000523:psychology*; D007124:Immunoenzyme Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018840:HSP70 Heat-Shock Proteins; D018799:Intercellular Adhesion Molecule-1