title: Are cardiomyocytes able to generate pre-amyloid peptides?
abstract: We performed ultrastructural testing of a cardiac biopsy taken from a heart with amyloidosis in which transthyretin mutation and light chain A amyloidosis were excluded. Cardiomyocytes of the affected heart showed accumulation of endosomal-like structures in which soluble amyloid oligomeric conformation was deposited. Intracellular accumulation of β -amyloid as well as phosphorylated tau protein seen in the immunohistochemical study suggest that the heart tissue may generate an amyloidogenic peptide leading to cardiomyocyte destruction and heart dysfunction.
authors: Neuromuscular Unit, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland. neurmyol@cmdik.pan.pl
authors: Anna
authors: A
authors: Fidziańska
authors: Ewa
authors: E
authors: Walczak
authors: Paweł
authors: P
authors: Bekta
authors: Lidia
authors: L
authors: Chojnowska
mesh_terms: D016229:Amyloid beta-Peptides / Q000096:biosynthesis*; D002313:Cardiomyopathy, Restrictive / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D046529:Microscopy, Electron, Transmission; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000648:ultrastructure*
chemical_list: D016229:Amyloid beta-Peptides