title: [Clostridium difficile-associated diarrhea: causes and relationship to reactive arthritis].
abstract: We present a patient treated with methotrexate (MTX] for rheumatoid arthritis, in whom clostridium difficile-associated colitis has developed, without preceding antibiotic treatment. Two weeks later, the patient was admitted with knee arthritis. Reactive arthritis was diagnosed and treated successfully with the naproxen. The article discusses risk factors for Clostridium difficile-associated diarrhea [CDAD] other than antibiotics, and the relation of this pathogen to the development of reactive arthritis. It seems to be the first report of the association of MTX treatment with CDAD.
authors: Department of Medicine F, Sheba Medical Center, Tel Hashomer, Israel.
authors: Alexey
authors: A
authors: Naimushin
authors: Shmuel
authors: S
authors: Eliasaf
authors: Avi
authors: A
authors: Livneh
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D016360:Clostridioides difficile / Q000302:isolation & purification; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000382:microbiology; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009288:Naproxen / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D009288:Naproxen; D008727:Methotrexate