title: AID and partners: for better and (not) for worse.
abstract: Post-rearrangement diversification of the antibody repertoire relies on a DNA editing factor, the cytidine deaminase AID. How B lymphocytes avoid generalized mutagenesis while expressing high levels of AID remained a long-standing question. Genome-wide studies of AID targeting combined to the discovery of several co-factors controlling its recruitment and its local activity shed new light on this enigma.
authors: Institut National de la Santé et de la Recherche Médicale Unité 783 Développement du système immunitaire, Université Paris Descartes, Faculté de Médecine, Site Necker-Enfants Malades, 156 rue de Vaugirard, 75730 Paris, Cedex 15, France.
authors: Sébastien
authors: S
authors: Storck
authors: Said
authors: S
authors: Aoufouchi
authors: Jean-Claude
authors: JC
authors: Weill
authors: Claude-Agnès
authors: CA
authors: Reynaud
mesh_terms: D000818:Animals; D003564:Cytidine Deaminase / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding; D013379:Substrate Specificity; D014158:Transcription, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
chemical_list: D007136:Immunoglobulins; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase