title: Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes.
abstract: Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single-nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1,085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls.
authors: Department of General Internal Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
authors: Charles R
authors: CR
authors: Jonassaint
authors: Jin Peng
authors: JP
authors: Szatkiewicz
authors: Cynthia M
authors: CM
authors: Bulik
authors: Laura M
authors: LM
authors: Thornton
authors: Cinnamon
authors: C
authors: Bloss
authors: Wade H
authors: WH
authors: Berrettini
authors: Walter H
authors: WH
authors: Kaye
authors: Andrew W
authors: AW
authors: Bergen
authors: Pierre
authors: P
authors: Magistretti
authors: Michael
authors: M
authors: Strober
authors: Pamela K
authors: PK
authors: Keel
authors: Harry
authors: H
authors: Brandt
authors: Steve
authors: S
authors: Crawford
authors: Scott
authors: S
authors: Crow
authors: Manfred M
authors: MM
authors: Fichter
authors: David
authors: D
authors: Goldman
authors: Katherine A
authors: KA
authors: Halmi
authors: Craig
authors: C
authors: Johnson
authors: Allan S
authors: AS
authors: Kaplan
authors: Kelly L
authors: KL
authors: Klump
authors: Maria
authors: M
authors: La Via
authors: James E
authors: JE
authors: Mitchell
authors: Alessandro
authors: A
authors: Rotondo
authors: Janet
authors: J
authors: Treasure
authors: D Blake
authors: DB
authors: Woodside
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D000856:Anorexia Nervosa / Q000235:genetics; D016022:Case-Control Studies; D001068:Feeding and Eating Disorders / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D009765:Obesity / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human