title: [Study on formulation of naoxuekang dispersible tablets].
abstract: OBJECTIVE
  To study the formulation of Naoxuekang dispersible tablets.
  
  
  METHODS
  The formulation was determined by pre-processing leech extractum prior to a series of experiments used to screen excipients like bulking agents and disintegrants and so on, and by adding disintegrants within and without.
  
  
  RESULTS
  Microcrystalline cellulose was determined as the bulking agent, and carboxymethyl cellulose and low-substituted hydroxypropyl cellulose were determined as the disintegrants of Naoxuekang dispersible tablet formula. The average disintegration time and nitrogen content of one tablet were 52 seconds and 5.47 milligrams, respectively. Also disperse homogeneity, weight variation and microbial limit all met the requirements in Ch. P.
  
  
  CONCLUSIONS
  The prepared Naoxuekang dispersible tablet is reasonable in formula, feasible in technology, which meets the quality standards.
authors: Key Laboratory of Advanced Drug Delivery of Guangdong Province, Institute of Material Medica, Guangdong College of Pharmacy, Guangzhou 510006, China.
authors: Mei-Yan
authors: MY
authors: Fu
authors: Zhu-Fen
authors: ZF
authors: Lv
authors: Yan-Zhong
authors: YZ
authors: Chen
authors: Qing-Chun
authors: QC
authors: Xie
authors: Lou
authors: L
authors: Shen
mesh_terms: D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000737:chemistry; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods*; D007865:Leeches; D008419:Materia Medica / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D012995:Solubility; D013607:Tablets / Q000737:chemistry
chemical_list: D008419:Materia Medica; D013607:Tablets; D002482:Cellulose; C008079:hydroxypropylcellulose; D002266:Carboxymethylcellulose Sodium; C109691:microcrystalline cellulose