title: Inverse association between serum phospholipid oleic acid and insulin resistance in subjects with primary dyslipidaemia.
abstract: OBJECTIVE
  Data on intake of oleic acid (OA) and insulin resistance (IR) are inconsistent. We investigated whether OA in serum phosphatidylcholine relates to surrogate measures of IR in dyslipidaemic subjects from a Mediterranean population.
  
  
  METHODS
  Cross-sectional study of 361 non-diabetic subjects (205 men, 156 women; mean age 44 and 46 y, respectively; BMI 25.7 kg/m(2)). IR was diagnosed by BMI and HOMA values using published criteria validated against the euglycemic clamp. Alternatively, IR was defined by the 75th percentile of HOMA-IR of our study population. The fatty acid composition of serum phosphatidylcholine was determined by gas-chromatography.
  
  
  RESULTS
  The mean (±SD) proportion of OA was 11.7 ± 2.0%. Ninety-two subjects (25.5%) had IR. By adjusted logistic regression, including the proportions of other fatty acids known to relate to IR, the odds ratios (OR) (95% confidence intervals) for IR were 0.75 (0.62-0.92) for 1% increase in OA and 0.84 (0.71-0.99) for 1% increase in linoleic acid. Other fatty acids were unrelated to IR. When using the alternate definition of IR, OA remained a significant predictor (0.80 [0.65-0.99]).
  
  
  CONCLUSIONS
  Higher phospholipid proportions of OA relate to less IR, suggesting an added benefit of increasing olive oil intake within the Mediterranean diet.
authors: Endocrinology and Nutrition Department, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain. asala@clinic.ub.es
authors: A
authors: A
authors: Sala-Vila
authors: M
authors: M
authors: Cofán
authors: R
authors: R
authors: Mateo-Gallego
authors: A
authors: A
authors: Cenarro
authors: F
authors: F
authors: Civeira
authors: E
authors: E
authors: Ortega
authors: E
authors: E
authors: Ros
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D038441:Diet, Mediterranean; D050171:Dyslipidemias / Q000097:blood* / Q000378:metabolism*; D005260:Female; D005638:Fruit / Q000737:chemistry; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance; D019787:Linoleic Acid / Q000032:analysis / Q000097:blood; D008297:Male; D008875:Middle Aged; D031658:Olea / Q000737:chemistry; D019301:Oleic Acid / Q000032:analysis / Q000097:blood*; D000069463:Olive Oil; D010713:Phosphatidylcholines / Q000097:blood* / Q000737:chemistry; D010743:Phospholipids / Q000097:blood / Q000737:chemistry; D010938:Plant Oils / Q000008:administration & dosage; D013030:Spain
chemical_list: D015415:Biomarkers; D000069463:Olive Oil; D010713:Phosphatidylcholines; D010743:Phospholipids; D010938:Plant Oils; D019301:Oleic Acid; D019787:Linoleic Acid