title: Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism.
abstract: Infection by the human immunodeficiency virus (HIV) involves a number of important interactions with lipid components in host membranes that regulate binding, fusion, internalization, and viral assembly. Available data suggests that HIV actively modifies the sphingolipid content of cellular membranes to create focal environments that are favorable for infection. In this review, we summarize the roles that membrane lipids play in HIV infection and discuss the current status of therapeutics that attempt to modify biological membranes to inhibit HIV.
authors: Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Meyer 6-109, 600N. Wolfe Street, Baltimore, MD 21287, USA. nhaughe1@jhmi.edu
authors: Norman J
authors: NJ
authors: Haughey
authors: Luis B
authors: LB
authors: Tovar-y-Romo
authors: Veera Venkata Ratnam
authors: VV
authors: Bandaru
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000639:trends*; D006678:HIV / Q000187:drug effects / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000378:metabolism / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects / Q000502:physiology; D008563:Membrane Lipids / Q000378:metabolism; D021962:Membrane Microdomains / Q000187:drug effects / Q000378:metabolism / Q000821:virology*; D014779:Virus Replication / Q000502:physiology*
chemical_list: D019380:Anti-HIV Agents; D008563:Membrane Lipids