title: Multimarker panels in sepsis.
abstract: Biomarkers differentiate between 2 or more biologic states. The complexity of diseases like sepsis makes it unlikely that any single marker will allow for precise disease specification. Combining several biomarkers into a single classification rule should help to improve their accuracy and, therefore, their usefulness. This article reviews several studies using multimarker panels, and highlights the potential of more sophisticated diagnostic and prognostic techniques in future multimarker panels. More complex algorithms should accelerate the adoption of multimarker panels into the routine management of patients with sepsis, provided that clinicians understand the multimarker approach.
authors: Division of Pulmonary and Critical Care Medicine, The Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02048, USA. brian_casserly@brown.edu
authors: Brian
authors: B
authors: Casserly
authors: Richard
authors: R
authors: Read
authors: Mitchell M
authors: MM
authors: Levy
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D003422:Critical Care; D006801:Humans; D018805:Sepsis / Q000378:metabolism*; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers