title: Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise.
abstract: L-Ornithine plays an important role in ammonia metabolism via the urea cycle. This study aimed to examine the effect of L-ornithine hydrochloride ingestion on ammonia metabolism and performance after intermittent maximal anaerobic cycle ergometer exercise. Ten healthy young adults (age, 23.8 ± 3.9 year; height, 172.3 ± 5.5 cm; body mass, 67.7 ± 6.1 kg) with regular training experience ingested L-ornithine hydrochloride (0.1 g/kg, body mass) or placebo after 30 s of maximal cycling exercise. Five sets of the same maximal cycling exercise were conducted 60 min after ingestion, and maximal cycling exercise was conducted after a 15 min rest. The intensity of cycling exercise was based on each subject's body mass (0.74 N kg(-1)). Work volume (watt), peak rpm (rpm) before and after intermittent maximal ergometer exercise and the following serum parameters were measured before ingestion, immediately after exercise and 15 min after exercise: ornithine, ammonia, urea, lactic acid and glutamate. Peak rpm was significantly greater with L-ornithine hydrochloride ingestion than with placebo ingestion. Serum ornithine level was significantly greater with L-ornithine hydrochloride ingestion than with placebo ingestion immediately and 15 min after intermittent maximal cycle ergometer exercise. In conclusion, although maximal anaerobic performance may be improved by L-ornithine hydrochloride ingestion before intermittent maximal anaerobic cycle ergometer exercise, the above may not depend on increase of ammonia metabolism with L-ornithine hydrochloride.
authors: Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa, 920-1192, Japan.
authors: Shinichi
authors: S
authors: Demura
authors: Koji
authors: K
authors: Morishita
authors: Takayoshi
authors: T
authors: Yamada
authors: Shunsuke
authors: S
authors: Yamaji
authors: Miho
authors: M
authors: Komatsu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000693:Anaerobiosis / Q000502:physiology; D054874:Athletic Performance / Q000502:physiology*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D008297:Male; D018763:Muscle Fatigue / Q000187:drug effects* / Q000502:physiology; D009952:Ornithine / Q000008:administration & dosage / Q000494:pharmacology*; D010507:Periodicity; D010919:Placebos; D020127:Recovery of Function / Q000187:drug effects*; D055815:Young Adult
chemical_list: D010919:Placebos; D009952:Ornithine