title: Effect of habitual exercise on renal carcinogenesis by ferric nitrilotriacetate.
abstract: OBJECTIVE
  We investigated whether habitual exercise (HE) (treadmill running) suppresses development of renal cell carcinoma (RCC) induced by ferric nitrilotriacetate (Fe-NTA).
  
  
  METHODS
  Male Fischer 344 rats were divided into six groups: group I, saline treatment (12 weeks = initiation period) and non-HE; group II, Fe-NTA treatment (12 weeks) and non-HE; group III, saline treatment and short-term (12 weeks) HE; group IV, Fe-NTA treatment and short-term HE; group V, saline treatment and long-term (40 weeks) HE; and group VI, Fe-NTA treatment and long-term HE. Saline treatment groups did not develop RCC, therefore we investigated the effects of HE among Fe-NTA treatment groups.
  
  
  RESULTS
  Gross nodules (diagnosed as RCC), RCC represented by microcarcinomas (Mcs), karyomegalic cells (KCs), and degenerative tubules (DTs) were seen in rats treated with Fe-NTA. The number of Mcs, KCs, and DTs were increased in the short-term HE group when compared with those in the non-HE group, but were decreased in the long-term HE group when compared with those in the short-term HE group.
  
  
  CONCLUSIONS
  Short-term (initiation period) HE promoted renal carcinogenesis induced by Fe-NTA; however, long-term HE after the initiation period suppressed the promoted carcinogenesis.
authors: Department of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
authors: Toyohiro
authors: T
authors: Kato
authors: Hiroaki
authors: H
authors: Kawaguchi
authors: Noriaki
authors: N
authors: Miyoshi
authors: Kohji
authors: K
authors: Aoyama
authors: Masaharu
authors: M
authors: Komatsu
authors: Masahisa
authors: M
authors: Horiuchi
authors: Hiroki
authors: H
authors: Yoshida
authors: Toru
authors: T
authors: Takeuchi
mesh_terms: D000818:Animals; D002273:Carcinogens; D002292:Carcinoma, Renal Cell / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D005290:Ferric Compounds; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives; D010805:Physical Conditioning, Animal; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D002273:Carcinogens; D005290:Ferric Compounds; D009571:Nitrilotriacetic Acid; C020326:ferric nitrilotriacetate