title: Gene expression profiling in MDS and AML: potential and future avenues.
abstract: Today, the classification systems for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) already incorporate cytogenetic and molecular genetic aberrations in an attempt to better reflect disease biology. However, in many MDS/AML patients no genetic aberrations have been identified yet, and even within some cytogenetically well-defined subclasses there is considerable clinical heterogeneity. Recent advances in genomics technologies such as gene expression profiling (GEP) provide powerful tools to further characterize myeloid malignancies at the molecular level, with the goal to refine the MDS/AML classification system, incorporating as yet unknown molecular genetic and epigenetic pathomechanisms, which are likely reflected by aberrant gene expression patterns. In this study, we provide a comprehensive review on how GEP has contributed to a refined molecular taxonomy of MDS and AML with regard to diagnosis, prediction of clinical outcome, discovery of novel subclasses and identification of novel therapeutic targets and novel drugs. As many challenges remain ahead, we discuss the pitfalls of this technology and its potential including future integrative studies with other genomics technologies, which will continue to improve our understanding of malignant transformation in myeloid malignancies and thereby contribute to individualized risk-adapted treatment strategies for MDS and AML patients.
authors: Biotech Research and Innovation Centre & Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors: K
authors: K
authors: Theilgaard-Mönch
authors: J
authors: J
authors: Boultwood
authors: S
authors: S
authors: Ferrari
authors: K
authors: K
authors: Giannopoulos
authors: J M
authors: JM
authors: Hernandez-Rivas
authors: A
authors: A
authors: Kohlmann
authors: M
authors: M
authors: Morgan
authors: B
authors: B
authors: Porse
authors: E
authors: E
authors: Tagliafico
authors: C M
authors: CM
authors: Zwaan
authors: J
authors: J
authors: Wainscoat
authors: M M
authors: MM
authors: Van den Heuvel-Eibrink
authors: K
authors: K
authors: Mills
authors: L
authors: L
authors: Bullinger
mesh_terms: D002965:Classification; D005544:Forecasting; D020869:Gene Expression Profiling / Q000639:trends; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000235:genetics*