title: Prevalence and severity of coronary artery disease in diabetic patients with aortic valve calcification.
abstract: OBJECTIVE
  Aortic valve calcification (AVC) is common in the elderly and associated with increased cardiovascular mortality, while diabetes is one of the confirmed risk factors for coronary artery disease (CAD). In this study, we aimed to evaluate the prevalence and severity of CAD in type-2 diabetic patients with AVC.
  
  
  METHODS
  From June to December in 2007, a total of 325 consecutive patients with chest pain or chest distress were admitted for coronary angiography. The severity of CAD was evaluated by the Gensini score and the number of stenosed vessels. All patients underwent transthoracic echocardiography for detecting AVC.
  
  
  RESULTS
  Compared with the patients without diabetes (n = 221), the type-2 diabetic patients (n = 104) had a similar prevalence of CAD (66.5% vs. 72.1%, P = 0.312). Further classified by the presence of AVC, patients with AVC had a higher prevalence of CAD, average Gensini score and the number of stenosed vessels, both in the group with and without diabetes. It was also demonstrated that the odds ratio (OR) of AVC for CAD in the diabetic patients was higher than in the non-diabetic ones (3.405 vs 2.515) after chi-square analysis (single-variable). However, at multivariable logistic regression analysis for CAD, the OR of AVC was 3.757 (P = 0.03) in diabetic group, while it did not achieve statistical significance in the non-diabetic group (OR = 2.130, P= 0.074).
  
  
  CONCLUSIONS
  Type-2 diabetic patients with AVC had a higher prevalence of and more severe CAD.
authors: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
authors: Zhang-wei
authors: ZW
authors: Chen
authors: Ju-ying
authors: JY
authors: Qian
authors: Ying
authors: Y
authors: Jian
authors: Lei
authors: L
authors: Ge
authors: Xue-bo
authors: XB
authors: Liu
authors: Xian-hong
authors: XH
authors: Shu
authors: Junbo
authors: J
authors: Ge
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000473:pathology*; D002114:Calcinosis / Q000453:epidemiology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000453:epidemiology*; D023921:Coronary Stenosis / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D005260:Female; D006349:Heart Valve Diseases / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012720:Severity of Illness Index