title: Association of 15q14 and 15q25 with high myopia in Japanese.
abstract: OBJECTIVE
  To investigate whether there are associations of genetic variations in chromosome 15q14 and 15q25, recently shown to confer risk of refractive error and myopia in Caucasians, with high myopia in Japanese.
  
  
  METHODS
  A total of 1125 unrelated Japanese patients with high myopia and two independent control groups were evaluated (366 cataract patients without high myopia and 929 healthy Japanese patients). The four single nucleotide polymorphisms (SNPs) rs634990 and rs524952 at 15q14 and rs8027411 and rs17175798 at 15q25 were genotyped.
  
  
  RESULTS
  A significant association with high myopia was observed in 15q14 (P = 0.0035 for rs634990 and P = 0.0017 for rs524952 when evaluated with cataract controls and P = 1.91 × 10(-6) for rs634990 and P = 8.78 × 10(-7) for rs524952 with healthy Japanese controls). When evaluated with cataract controls, the odds ratios (95% confidence intervals) were 1.30 (1.10-1.53) for rs634990 C allele and 1.32 (1.11-1.56) for rs524952 A allele. The population attributable risks were 0.29 and 0.30, respectively. The SNPs in 15q25 did not show a significant association with high myopia when evaluated with cataract control (P > 0.42), while it showed a weak association when evaluated with healthy Japanese controls (P = 0.031 for rs8027411 and P = 0.047 for rs17175798) with odds ratios of 1.17 (1.03-1.33) for rs8027411 T allele and 1.15 (1.02-1.31) for rs17175798 C allele.
  
  
  CONCLUSIONS
  These findings suggest that a region in 15q14 is susceptibility loci for high myopia. This locus harbor susceptibility genes for not only common myopia but also for high myopia. The 15q25 locus might also have association to myopia.
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: Hisako
authors: H
authors: Hayashi
authors: Kenji
authors: K
authors: Yamashiro
authors: Hideo
authors: H
authors: Nakanishi
authors: Isao
authors: I
authors: Nakata
authors: Yumiko
authors: Y
authors: Kurashige
authors: Akitaka
authors: A
authors: Tsujikawa
authors: Muka
authors: M
authors: Moriyama
authors: Kyoko
authors: K
authors: Ohno-Matsui
authors: Manabu
authors: M
authors: Mochizuki
authors: Mineo
authors: M
authors: Ozaki
authors: Ryo
authors: R
authors: Yamada
authors: Fumihiko
authors: F
authors: Matsuda
authors: Nagahisa
authors: N
authors: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D012029:Refraction, Ocular; D012720:Severity of Illness Index