title: Functional resting-state networks are differentially affected in schizophrenia.
abstract: Neurobiological theories posit that schizophrenia relates to disturbances in connectivity between brain regions. Resting-state functional magnetic resonance imaging is a powerful tool for examining functional connectivity and has revealed several canonical brain networks, including the default mode, dorsal attention, executive control, and salience networks. The purpose of this study was to examine changes in these networks in schizophrenia. 42 patients with schizophrenia and 61 healthy subjects completed a RS-fMRI scanning session. Seed-based region-of-interest correlation analysis was used to identify the default mode, dorsal attention, executive control, and salience networks. Compared to healthy subjects, individuals with schizophrenia demonstrated greater connectivity between the posterior cingulate cortex, a key hub of the default mode, and the left inferior gyrus, left middle frontal gyrus, and left middle temporal gyrus. Interestingly, these regions were more strongly connected to the executive control network in healthy control subjects. In contrast to the default mode, patients demonstrated less connectivity in the executive control and dorsal attention networks. No differences were observed in the salience network. The results indicate that resting-state networks are differentially affected in schizophrenia. The alterations are characterized by reduced segregation between the default mode and executive control networks in the prefrontal cortex and temporal lobe, and reduced connectivity in the dorsal attention and executive control networks. The changes suggest that the process of functional specialization is altered in schizophrenia. Further work is needed to determine if the alterations are related to disturbances in white matter connectivity, neurodevelopmental abnormalities, and genetic risk for schizophrenia.
authors: Psychotic Disorders Program, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, United States. neil.woodward@vanderbilt.edu
authors: Neil D
authors: ND
authors: Woodward
authors: Baxter
authors: B
authors: Rogers
authors: Stephan
authors: S
authors: Heckers
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000473:pathology*; D001931:Brain Mapping; D017352:Echo-Planar Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000503:physiopathology; D012146:Rest / Q000502:physiology*; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*; D013223:Statistics as Topic; D055815:Young Adult