title: Efficacy of topical combination of benzoyl peroxide 5% and clindamycin 1% for the treatment of progressive macular hypomelanosis: a randomized, doubleblind, placebo-controlled trial.
abstract: BACKGROUND
  Progressive macular hypomelanosis is a dermatosis without definite etiology. There is no consensus or first-line therapy in the treatment of progressive macular hypomelanosis, and the treatment options used are very little effective.
  
  
  OBJECTIVE
  To evaluate the therapeutic efficacy of the topical combination of benzoyl peroxide 5% and clindamycin 1% associated with sun exposure for the treatment of progressive macular hypomelanosis.
  
  
  METHODS
  This is a randomized, double-blind, placebo-controlled study in which patients were divided into two groups. Group A used the topical combination of benzoyl peroxide 5% and clindamycin 1% and Group B used gel cream as a placebo. Patients were advised to expose themselves to the sun on a daily basis and were systematically evaluated and photographed. The collected data were entered and analyzed using Epi Info. A p value < 0.05 was considered statistically significant.
  
  
  RESULTS
  Out of the 23 patients included in the study, 13 were in group A and 10 in group B. Eleven patients (85%) in group A had significant clinical improvement and only two patients (20%) in group B showed an equivalent clinical improvement (p = 0.003). Side effects were more frequent in group A (p = 0.003).
  
  
  CONCLUSIONS
  The topical combination of benzoyl peroxide 5% and clindamycin 1% is effective in the treatment of progressive macular hypomelanosis.
authors: Bahia School of Medicine and Public Health, Salvador, BA, Brasil. jussamarabrito@gmail.com
authors: Jussamara Brito
authors: JB
authors: Santos
authors: Olga Laura Sena
authors: OL
authors: Almeida
authors: Lorena Marçal da
authors: LM
authors: Silva
authors: Enio Ribeiro Maynard
authors: ER
authors: Barreto
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000367:Age Factors; D000368:Aged; D001585:Benzoyl Peroxide / Q000627:therapeutic use*; D002981:Clindamycin / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010919:Placebos / Q000627:therapeutic use; D012737:Sex Factors; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D002981:Clindamycin; D001585:Benzoyl Peroxide