title: Remarkable similarity in genome nucleotide sequences between the Schwarz FF-8 and AIK-C measles virus vaccine strains and apparent nucleotide differences in the phosphoprotein gene.
abstract: The Schwarz FF-8 (FF-8) and AIK-C measles virus vaccine strains are currently used for vaccination in Japan. Here, the complete genome nucleotide sequence of the FF-8 strain has been determined and its genome sequence found to be remarkably similar to that of the AIK-C strain. These two strains are differentiated only by two nucleotide differences in the phosphoprotein gene. Since the FF-8 strain does not possess the amino acid substitutions in the phospho- and fusion proteins which are responsible for the temperature-sensitivity and small syncytium formation phenotypes of the AIK-C strain, respectively, other unidentified common mechanisms likely attenuate both the FF-8 and AIK-C strains.
authors: Department of Virology, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka, Osaka, Japan.
authors: Chie
authors: C
authors: Ito
authors: Shinji
authors: S
authors: Ohgimoto
authors: Seiichi
authors: S
authors: Kato
authors: Luna Bhatta
authors: LB
authors: Sharma
authors: Minoru
authors: M
authors: Ayata
authors: Katsuhiro
authors: K
authors: Komase
authors: Kaoru
authors: K
authors: Takeuchi
authors: Toshiaki
authors: T
authors: Ihara
authors: Hisashi
authors: H
authors: Ogura
mesh_terms: D019943:Amino Acid Substitution; D016679:Genome, Viral; D006801:Humans; D007564:Japan; D008458:Measles Vaccine / Q000235:genetics*; D008459:Measles virus / Q000235:genetics*; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D010750:Phosphoproteins / Q000235:genetics*; D017354:Point Mutation; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D014613:Vaccines, Attenuated; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D008458:Measles Vaccine; C055859:P protein, Sendai virus; D010750:Phosphoproteins; D014613:Vaccines, Attenuated; D014764:Viral Proteins