title: Motor deficits on a ladder rung task in male and female adolescent and adult CGG knock-in mice.
abstract: The fragile X premutation is a tandem CGG trinucleotide repeat expansion on the FMR1 gene between 55 and 200 repeats in length. A CGG knock-in (CGG KI) mouse with CGG trinucleotide repeat lengths between 70 and 350 has been developed and used to model the histopathology and cognitive deficits reported in carriers of the fragile X premutation. Previous studies have shown that CGG KI mice show progressive deficits in processing spatial and temporal information. To characterize the motor deficits associated with the fragile X premutation, male and female CGG KI mice ranging from 2 to 16 months of age with trinucleotide repeats ranging from 72 to 240 CGG in length were tested for their ability to perform a skilled ladder rung walking test. The results demonstrate that both male and female CGG KI mice showed a greater number of foot slips as a function of increased CGG repeat length, independent of the age of the animal or general activity level.
authors: Department of Neurological Surgery, School of Medicine, University of California, Davis; Davis, CA 95616, USA. ryanhunsaker@me.com
authors: Michael R
authors: MR
authors: Hunsaker
authors: Ramona E
authors: RE
authors: von Leden
authors: Binh T
authors: BT
authors: Ta
authors: Naomi J
authors: NJ
authors: Goodrich-Hunsaker
authors: Gloria
authors: G
authors: Arque
authors: Kyoungmi
authors: K
authors: Kim
authors: Rob
authors: R
authors: Willemsen
authors: Robert F
authors: RF
authors: Berman
mesh_terms: D000375:Aging / Q000235:genetics*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D005260:Female; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics*; D005838:Genotype; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009069:Movement Disorders / Q000235:genetics* / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology*; D012727:Sex Characteristics; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; C497684:Fmr1 protein, mouse