title: Levels of awakening salivary CgA in response to stress in healthy subjects.
abstract: OBJECTIVE
  To determine the changes in salivary chromogranin A (CgA) levels upon awakening in response to of stress by investigating the relationship between salivary CgA levels and the stress response as assessed by GHQ-28 tests.
  
  
  METHODS
  The study cohort comprised 40 healthy male university students (age range 19-22 years). Salivary CgA levels were measured at 7:00 a.m. (awakening) and at 7:30, 8:00, and 8:30 a.m. (after awakening).
  
  
  RESULTS
  The salivary CgA level was 0.91 ± 0.20 and 0.42 ± 0.1 pmol/ml at 7:00 a.m. in students scoring low (n = 26) and high (n = 14), respectively, on the "severe depression" subscale. This difference in salivary CgA levels at 7:00 between high and low scorers was statistically significant (p < 0.05).
  
  
  CONCLUSIONS
  Our findings indicate that depression may influence secretions of salivary CgA via chronic stress-related attenuation of the sympathetic-adrenomedullary system activity.
authors: Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
authors: Rei
authors: R
authors: Den
authors: Masahiro
authors: M
authors: Toda
authors: Masako
authors: M
authors: Ohira
authors: Kanehisa
authors: K
authors: Morimoto
mesh_terms: D015415:Biomarkers / Q000032:analysis; D053379:Chromogranin A / Q000032:analysis* / Q000502:physiology; D003866:Depressive Disorder / Q000503:physiopathology; D006801:Humans; D007564:Japan; D008297:Male; D012463:Saliva / Q000737:chemistry*; D012890:Sleep; D013315:Stress, Psychological / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D053379:Chromogranin A