title: JAK3 specific kinase inhibitors: when specificity is not enough.
abstract: Janus kinases are important signaling proteins implicated in cytokine signaling. In particular, Janus kinase 3 (JAK3) has gained attention as a target for inhibition of the immune system, due to its importance for T and B cell development and function. In this issue however, Haan et al. (2011) show that inhibition of JAK3 activity may not be sufficient for this purpose.
authors: Center for Human Genetics, K.U.Leuven, Leuven, B-3000, Belgium.
authors: Luk
authors: L
authors: Cox
authors: Jan
authors: J
authors: Cools