title: Associated malignancies in patients with Waldenström's macroglobulinemia and their kin.
abstract: We examined the incidence of other malignancies in 924 Waldenström's Macroglobulinemia (WM) patients and their kin. A total of 225 (24.3%) patients had ≥1 additional malignancy, with 63% predating the WM diagnosis. The most common gender-adjusted malignancies were prostate (9.4%), breast (8.0%), non-melanoma skin (7.1%), hematologic (2.8%), melanoma (2.2%), lung (1.4%) and thyroid 1.1%). Among hematologic malignancies, all 13 cases of diffuse large B-cell lymphoma and 4 cases of acute myelogenous leukemia were diagnosed after WM, and were therapy-related. Familial WM subgroup analysis showed a higher incidence of prostate cancer (P=.046) in sporadic WM patients, while patients with familial WM had a higher incidence of lung cancer (P=.0043). An increased incidence of myeloid leukemias (P<.0001) was reported among kin of familial WM patients. These data reveal specific cancer associations with WM, and provide a basis for exploratory studies aimed at delineating a common genetic basis. Additionally, these studies suggest specific cancer clustering based on familial predisposition to WM.
authors: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
authors: Christina
authors: C
authors: Hanzis
authors: Rohit P
authors: RP
authors: Ojha
authors: Zachary
authors: Z
authors: Hunter
authors: Robert
authors: R
authors: Manning
authors: Megan
authors: M
authors: Lewicki
authors: Philip
authors: P
authors: Brodsky
authors: Leukothea
authors: L
authors: Ioakimidis
authors: Christina
authors: C
authors: Tripsas
authors: Christopher J
authors: CJ
authors: Patterson
authors: Patricia
authors: P
authors: Sheehy
authors: Steven P
authors: SP
authors: Treon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics