title: Specific increase in serum autotaxin activity in patients with pancreatic cancer.
abstract: OBJECTIVE
  To evaluate the potential clinical significance of serum autotaxin (ATX) level in patients with cancers of the digestive system.
  
  
  METHODS
  Serum ATX activity was measured as the lysophospholipase D activity in patients with cancer of the esophagus (n=8), stomach (n=18), colorectum (n=21), biliary tract (n=19), or pancreas (n=103) and in patients with benign pancreatic diseases (n=73).
  
  
  RESULTS
  Among patients with various cancers of digestive system, increased serum ATX activity was predominantly observed among pancreatic cancer patients. Serum ATX activity was not increased in patients with chronic pancreatitis or pancreatic cysts. In the diagnosis of pancreatic cancer, the area under the receiver operating curve for serum ATX activity was 0.541 (95% CI, 0.435-0.648) for men and 0.772 (95% CI, 0.659-0.885) for women. No significant correlation was observed between serum ATX activity and CEA, CA19-9 or Dupan2 levels.
  
  
  CONCLUSIONS
  Serum ATX activity may be useful for identifying pancreatic cancer when used together with other serum markers of pancreatic cancer.
authors: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Yousuke
authors: Y
authors: Nakai
authors: Hitoshi
authors: H
authors: Ikeda
authors: Kazuhiro
authors: K
authors: Nakamura
authors: Yukio
authors: Y
authors: Kume
authors: Mitsuhiro
authors: M
authors: Fujishiro
authors: Naoki
authors: N
authors: Sasahira
authors: Kenji
authors: K
authors: Hirano
authors: Hiroyuki
authors: H
authors: Isayama
authors: Minoru
authors: M
authors: Tada
authors: Takao
authors: T
authors: Kawabe
authors: Yutaka
authors: Y
authors: Komatsu
authors: Masao
authors: M
authors: Omata
authors: Junken
authors: J
authors: Aoki
authors: Kazuhiko
authors: K
authors: Koike
authors: Yutaka
authors: Y
authors: Yatomi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000097:blood; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D015151:Immunoblotting; D008246:Lysophospholipids / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009097:Multienzyme Complexes / Q000097:blood* / Q000378:metabolism; D010181:Pancreatic Cyst / Q000097:blood / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000378:metabolism; D050500:Pancreatitis, Chronic / Q000097:blood / Q000378:metabolism; D043264:Phosphodiesterase I / Q000097:blood* / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases / Q000097:blood* / Q000378:metabolism; D000099189:Lysophospholipase D
chemical_list: D002272:Carcinoembryonic Antigen; D008246:Lysophospholipids; D009097:Multienzyme Complexes; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases; D000099189:Lysophospholipase D