title: Valproate for the treatment of medication-induced impulse-control disorders in three patients with Parkinson's disease.
abstract: Impulse-control disorders (ICDs) are becoming more commonly recognized in the Parkinson disease (PD) population. To date, there are no definitive methods of treating dopamine dysregulation syndromes in PD patients. We sought to uncover an effective treatment option for future study. We report a series of 3 PD patients with ICDs who were effectively treated with valproate. Based on these encouraging preliminary observations, future controlled clinical trials investigating the efficacy of valproate for ICDs in PD are recommended.
authors: Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
authors: C W
authors: CW
authors: Hicks
authors: M M
authors: MM
authors: Pandya
authors: I
authors: I
authors: Itin
authors: H H
authors: HH
authors: Fernandez
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D000978:Antiparkinson Agents / Q000009:adverse effects; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D000978:Antiparkinson Agents; D007980:Levodopa; D014635:Valproic Acid