title: Relationship between time to target temperature and outcome in patients treated with therapeutic hypothermia after cardiac arrest.
abstract: BACKGROUND
  Our purpose was to study whether the time to target temperature correlates with neurologic outcome in patients after cardiac arrest with restoration of spontaneous circulation treated with therapeutic mild hypothermia in an academic emergency department.
  
  
  METHODS
  Temperature data between April 1995 and June 2008 were collected from 588 patients and analyzed in a retrospective cohort study by observers blinded to outcome. The time needed to achieve an esophageal temperature of less than 34°C was recorded. Survival and neurological outcomes were determined within six months after cardiac arrest.
  
  
  RESULTS
  The median time from restoration of spontaneous circulation to reaching a temperature of less than 34°C was 209 minutes (interquartile range [IQR]: 130-302) in patients with favorable neurological outcomes compared to 158 min (IQR: 101-230) (P < 0.01) in patients with unfavorable neurological outcomes. The adjusted odds ratio for a favorable neurological outcome with a longer time to target temperature was 1.86 (95% CI 1.03 to 3.38, P = 0.04).
  
  
  CONCLUSIONS
  In comatose cardiac arrest patients treated with therapeutic hypothermia after return of spontaneous circulation, a faster decline in body temperature to the 34°C target appears to predict an unfavorable neurologic outcome.
authors: Department of Emergency Medicine, Medical University of Vienna, Währinger Gürtel 18-20/6D, Wien, 1090, Austria.
authors: Moritz
authors: M
authors: Haugk
authors: Christoph
authors: C
authors: Testori
authors: Fritz
authors: F
authors: Sterz
authors: Maximilian
authors: M
authors: Uranitsch
authors: Michael
authors: M
authors: Holzer
authors: Wilhelm
authors: W
authors: Behringer
authors: Harald
authors: H
authors: Herkner
mesh_terms: D000368:Aged; D001775:Blood Circulation / Q000502:physiology; D001831:Body Temperature; D005260:Female; D006323:Heart Arrest / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome