title: Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese.
abstract: OBJECTIVE
  We aimed to investigate how lean body mass is related to circulating Interleukin 18 (IL-18) and its association with metabolic syndrome (MetS) among apparently healthy Chinese.
  
  
  METHODS
  A population-based sample of 1059 Chinese men and women aged 35-54 years was used to measure plasma IL-18, glucose, insulin, lipid profile, inflammatory markers and high-molecular-weight (HMW)-adiponectin. Fat mass index (FMI) and lean mass index (LMI) were measured by dual-energy X-ray absorptiometry. MetS was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans.
  
  
  RESULTS
  Circulating IL-18 was positively correlated with LMI after adjustment for FMI (correlation coefficient = 0.11, P<0.001). The association with the MetS (odds ratio 3.43, 95% confidence interval 2.01-5.85) was substantially higher in the highest than the lowest quartile of IL-18 after multiple adjustments including body mass index. In the stratified multivariable regression analyses, the positive association between IL-18 and MetS was independent of tertiles of FMI, inflammatory markers and HMW-adiponectin, but significantly interacted with tertile of LMI (P for interaction = 0.010).
  
  
  CONCLUSIONS
  Elevated plasma IL-18 was associated with higher MetS prevalence in apparently healthy Chinese, independent of traditional risk factors, FMI, inflammatory markers and HMW-adiponectin. More studies are needed to clarify the role of lean mass in IL-18 secretion and its associated cardio-metabolic disorders.
authors: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China.
authors: Liang
authors: L
authors: Sun
authors: Frank B
authors: FB
authors: Hu
authors: Zhijie
authors: Z
authors: Yu
authors: Huaixing
authors: H
authors: Li
authors: Huaiyu
authors: H
authors: Liu
authors: Xiangdong
authors: X
authors: Wang
authors: Danxia
authors: D
authors: Yu
authors: Hongyu
authors: H
authors: Wu
authors: Geng
authors: G
authors: Zhang
authors: Geng
authors: G
authors: Zong
authors: Yong
authors: Y
authors: Liu
authors: Xu
authors: X
authors: Lin
mesh_terms: D000328:Adult; D044466:Asian People; D001823:Body Composition / Q000502:physiology; D001835:Body Weight / Q000502:physiology*; D002681:China; D016001:Confidence Intervals; D005260:Female; D006262:Health; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D008875:Middle Aged; D016017:Odds Ratio; D018709:Statistics, Nonparametric; D013851:Thinness / Q000097:blood* / Q000150:complications* / Q000503:physiopathology
chemical_list: D020382:Interleukin-18