title: In vivo three-dimensional optical coherence elastography.
abstract: We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum in the hydrated case.
authors: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia, Crawley, Western Australia, Australia. brendank@ee.uwa.edu.au
authors: Brendan F
authors: BF
authors: Kennedy
authors: Xing
authors: X
authors: Liang
authors: Steven G
authors: SG
authors: Adie
authors: Derek K
authors: DK
authors: Gerstmann
authors: Bryden C
authors: BC
authors: Quirk
authors: Stephen A
authors: SA
authors: Boppart
authors: David D
authors: DD
authors: Sampson
mesh_terms: D046169:Dermoscopy / Q000295:instrumentation*; D054459:Elasticity Imaging Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012867:Skin / Q000000981:diagnostic imaging*; D012879:Skin Physiological Phenomena; D041623:Tomography, Optical Coherence / Q000295:instrumentation*