title: Clinicopathologic analysis of extramammary Paget's disease.
abstract: OBJECTIVE
  To retrospectively analyze the clinicopathologic characteristics of patients with extramammary Paget's disease who were surgically treated in a single institution.
  
  
  METHODS
  The charts of 14 patients with extramammary Paget's disease were retrospectively reviewed, and the clinicopathologic data were collected and analyzed.
  
  
  RESULTS
  From January 1990 to July 2009, 14 patients were treated at our institution. Most patients (11/14 patients) had delayed diagnosis. Two patients (14.3%) had associated malignant neoplasms. Eight of 14 patients (57.1%) had positive surgical margins; of these patients, five patients had no evidence of recurrence. In the six patients with negative surgical margins, two patients (33.3%) developed recurrence.
  
  
  CONCLUSIONS
  The diagnosis of extramammary Paget's disease is commonly delayed. Because of the possible association with other malignancies before or after the diagnosis of extramammary Paget's disease, thorough examinations are recommended. Disease recurrence is common regardless of the surgical margin status, so long-term monitoring of patients is recommended.
authors: Department of Obstetrics and Gynecology, School of Medicine, Catholic University, Seoul St. Mary's Hospital, Seoul, Korea.
authors: C W
authors: CW
authors: Lee
authors: M J
authors: MJ
authors: Song
authors: S H
authors: SH
authors: Lee
authors: J H
authors: JH
authors: Kim
authors: S J
authors: SJ
authors: Lee
authors: K H
authors: KH
authors: Lee
authors: J S
authors: JS
authors: Park
authors: S Y
authors: SY
authors: Hur
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D014844:Vulva / Q000601:surgery; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery