title: Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study.
abstract: Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.
authors: Unité d'Endocrinologie-Gynécologie Pédiatrique, Service de Pédiatrie I, Hôpital Arnaud de Villeneuve, CHU Montpellier and Université Montpellier, France.
authors: Nicolas
authors: N
authors: Kalfa
authors: Françoise
authors: F
authors: Paris
authors: Marie-Odile
authors: MO
authors: Soyer-Gobillard
authors: Jean-Pierre
authors: JP
authors: Daures
authors: Charles
authors: C
authors: Sultan
mesh_terms: D015988:Cohort Effect; D015331:Cohort Studies; D004054:Diethylstilbestrol / Q000009:adverse effects*; D052244:Endocrine Disruptors / Q000009:adverse effects*; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D005602:France; D006801:Humans; D007021:Hypospadias / Q000139:chemically induced / Q000453:epidemiology* / Q000235:genetics; D008297:Male; D018811:Maternal Exposure; D010375:Pedigree; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D052244:Endocrine Disruptors; D004968:Estrogens, Non-Steroidal; D004054:Diethylstilbestrol