title: Discovery of a genome of a distant relative of chicken anemia virus reveals a new member of the genus Gyrovirus.
abstract: A 2.4-kb phi29 polymerase amplification product from serum of a diseased chicken was cloned and sequenced. The 2383-nucleotide sequence showed about 40% identity to a representative genome of chicken anemia virus (CAV), the only member of the genus Gyrovirus, family Circoviridae. The new genome had an organization similar to that of CAV: a putative 5' untranscribed region of about 400 nt followed by three partially overlapping open reading frames encoding VP1, VP2 and VP3 homologs. The amino acid identities between these homologs and those of CAV were 38.8%, 40.3%, and 32.2%, respectively. Based on these limited similarities, it is proposed that the newly identified virus is a member of a new species in the genus Gyrovirus. For this new species, the name Avian gyrovirus 2 (AGV2) is proposed.
authors: Virology Laboratory, Microbiology Department, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Av. Sarmento Leite 500, Porto Alegre, Rio Grande do Sul (RS), CEP 90050-170, Brazil. frans@rijsewijk.com
authors: Franciscus A M
authors: FA
authors: Rijsewijk
authors: Helton F
authors: HF
authors: Dos Santos
authors: Thais F
authors: TF
authors: Teixeira
authors: Samuel P
authors: SP
authors: Cibulski
authors: Ana P M
authors: AP
authors: Varela
authors: Diogenes
authors: D
authors: Dezen
authors: Ana C
authors: AC
authors: Franco
authors: Paulo M
authors: PM
authors: Roehe
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017727:Chicken anemia virus / Q000145:classification / Q000235:genetics*; D002645:Chickens / Q000821:virology*; D018173:Circoviridae Infections / Q000662:veterinary* / Q000821:virology; D016679:Genome, Viral; D046810:Gyrovirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D011201:Poultry Diseases / Q000821:virology*; D017422:Sequence Analysis, DNA