title: Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice.
abstract: OBJECTIVE
  To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice.
  
  
  METHODS
  Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II - β-lapachone, in group III - vehicle (diluent) and in group IV - vehicle + AOM and finally in group V - β-lapachone + AOM.
  
  
  RESULTS
  It was observed the presence of aberrant crypt foci in all animals of groups I and IV, 50% in group II and 90% in group V.
  
  
  CONCLUSIONS
  The β-lapachone extracted from the Tabebuia avellanedae showed no protective effect of lesions induced by azoxymethane in colon of mice.
authors: Health and Development Postgraduate Program, UFMS, Campo Grande-MS, Brazil.
authors: Roberta Alves
authors: RA
authors: Higa
authors: Ricardo Dutra
authors: RD
authors: Aydos
authors: Iandara Schettert
authors: IS
authors: Silva
authors: Rondon Tosta
authors: RT
authors: Ramalho
authors: Albert Schiaveto de
authors: AS
authors: Souza
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001397:Azoxymethane; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D029663:Tabebuia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002273:Carcinogens; D010936:Plant Extracts; D001397:Azoxymethane