title: The potential usefulness of taurine on diabetes mellitus and its complications.
abstract: Taurine (2-aminoethanesulfonic acid) is a free amino acid found ubiquitously in millimolar concentrations in all mammalian tissues. Taurine exerts a variety of biological actions, including antioxidation, modulation of ion movement, osmoregulation, modulation of neurotransmitters, and conjugation of bile acids, which may maintain physiological homeostasis. Recently, data is accumulating that show the effectiveness of taurine against diabetes mellitus, insulin resistance and its complications, including retinopathy, nephropathy, neuropathy, atherosclerosis and cardiomyopathy, independent of hypoglycemic effect in several animal models. The useful effects appear due to the multiple actions of taurine on cellular functions. This review summarizes the beneficial effects of taurine supplementation on diabetes mellitus and the molecular mechanisms underlying its effectiveness.
authors: Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, 1-3-6 Minatojima, Chuo-ku, Kobe, Hyogo, 650-8530, Japan.
authors: Takashi
authors: T
authors: Ito
authors: Stephen W
authors: SW
authors: Schaffer
authors: Junichi
authors: J
authors: Azuma
mesh_terms: D000818:Animals; D048909:Diabetes Complications / Q000188:drug therapy*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D017127:Glycation End Products, Advanced; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000188:drug therapy; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D013654:Taurine / Q000008:administration & dosage*
chemical_list: D017127:Glycation End Products, Advanced; D013654:Taurine