title: Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+ lymphocytopenia.
abstract: A 40-year-old man with severe chronic idiopathic CD4+ lymphocytopenia complicated with opportunistic infections was successfully treated with non-myeloablative allogeneic hematopoietic stem cell transplantation. After conditioning with fludarabine plus low dose of total-body irradiation, CD34+ peripheral blood stem cells obtained by leukapheresis from his HLA-identical sister were infused. T cell and myeloid complete chimerism was achieved at day +28 and remained stable during the follow-up period. The patient did not develop infectious complications during the procedure. At 35 months of follow-up, his CD4+ T cell count was 1019 cells per microliter. Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia.
authors: Services of Infectious Diseases, Hospital Clinic of Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain. ccervera@clinic.ub.es
authors: Carlos
authors: C
authors: Cervera
authors: Francesc
authors: F
authors: Fernández-Avilés
authors: Oscar
authors: O
authors: de la Calle-Martin
authors: Xavier
authors: X
authors: Bosch
authors: Montserrat
authors: M
authors: Rovira
authors: Montse
authors: M
authors: Plana
authors: Asunción
authors: A
authors: Moreno
authors: Felipe
authors: F
authors: García
authors: Jose M
authors: JM
authors: Miró
authors: Antonio
authors: A
authors: Martínez
authors: Teresa
authors: T
authors: Gallart
authors: Enric
authors: E
authors: Carreras
authors: Joan
authors: J
authors: Blade
authors: Jose M
authors: JM
authors: Gatell
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D049109:Cell Proliferation; D005260:Female; D006680:HLA Antigens; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D019653:Myeloablative Agonists / Q000627:therapeutic use; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous
chemical_list: D006680:HLA Antigens; D019653:Myeloablative Agonists