title: Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler Memory Scale-Revised logical/verbal memory score for healthy subjects.
abstract: BACKGROUND
  Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM).
  
  
  METHODS
  T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A P value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant.
  
  
  RESULTS
  Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal, T value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal, T value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found.
  
  
  CONCLUSIONS
  To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing.
authors: Department of Radiological Technology, Graduate School of Medicine, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. car6_pa2_rw@yahoo.co.jp
authors: Masami
authors: M
authors: Goto
authors: Osamu
authors: O
authors: Abe
authors: Tosiaki
authors: T
authors: Miyati
authors: Takeharu
authors: T
authors: Yoshikawa
authors: Naoto
authors: N
authors: Hayashi
authors: Hidemasa
authors: H
authors: Takao
authors: Sachiko
authors: S
authors: Inano
authors: Hiroyuki
authors: H
authors: Kabasawa
authors: Harushi
authors: H
authors: Mori
authors: Akira
authors: A
authors: Kunimatsu
authors: Shigeki
authors: S
authors: Aoki
authors: Kenji
authors: K
authors: Ino
authors: Kyouhito
authors: K
authors: Iida
authors: Keiichi
authors: K
authors: Yano
authors: Kuni
authors: K
authors: Ohtomo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018728:Entorhinal Cortex / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D014888:Wechsler Scales