title: Segmental analysis of indocyanine green pharmacokinetics for the reliable diagnosis of functional vascular insufficiency.
abstract: Accurate and reliable diagnosis of functional insufficiency of peripheral vasculature is essential since Raynaud phenomenon (RP), most common form of peripheral vascular insufficiency, is commonly associated with systemic vascular disorders. We have previously demonstrated that dynamic imaging of near-infrared fluorophore indocyanine green (ICG) can be a noninvasive and sensitive tool to measure tissue perfusion. In the present study, we demonstrated that combined analysis of multiple parameters, especially onset time and modified T(max) which means the time from onset of ICG fluorescence to T(max), can be used as a reliable diagnostic tool for RP. To validate the method, we performed the conventional thermographic analysis combined with cold challenge and rewarming along with ICG dynamic imaging and segmental analysis. A case-control analysis demonstrated that segmental pattern of ICG dynamics in both hands was significantly different between normal and RP case, suggesting the possibility of clinical application of this novel method for the convenient and reliable diagnosis of RP.
authors: Yujung
authors: Y
authors: Kang
authors: Jungsul
authors: J
authors: Lee
authors: Yuri
authors: Y
authors: An
authors: Jongwook
authors: J
authors: Jeon
authors: Chulhee
authors: C
authors: Choi
mesh_terms: D000328:Adult; D004396:Coloring Agents / Q000493:pharmacokinetics; D005260:Female; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008297:Male; D055620:Optical Phenomena; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D011928:Raynaud Disease / Q000175:diagnosis; D019265:Spectroscopy, Near-Infrared
chemical_list: D004396:Coloring Agents; D005456:Fluorescent Dyes; D007208:Indocyanine Green