title: Palladium-catalyzed C,N-cross coupling reactions of 3-halo-2-aminopyridines.
abstract: A simple approach toward N(3)-substituted-2,3-diaminopyridines is presented, based on Pd-catalyzed C,N-cross coupling. The use of RuPhos- and BrettPhos-precatalysts in combination with LiHMDS allows for C,N-cross coupling reactions of unprotected 3-halo-2-aminopyridines with primary and secondary amines.
authors: Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799, USA.
authors: Felix
authors: F
authors: Perez
authors: Ana
authors: A
authors: Minatti
mesh_terms: D000586:Amination; D000631:Aminopyridines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000631:Aminopyridines; D003432:Cross-Linking Reagents; D008024:Ligands; D010165:Palladium; D002244:Carbon; D009584:Nitrogen