title: Neuroendocrine differentiation in a case of cervical cancer.
abstract: Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiation, as demonstrated by chromogranin-A positivity. It is important to differentiate small cell carcinoma from other malignant tumors of the uterine cervix. Morphological features play an important role in making a diagnosis and the immunohistochemistry study can offer an additional useful assistance.
authors: Department of Pathology, Damanhour National Medical Institute, General Organization of Teaching Hospitals and Institutes, Egypt.
authors: Mona Mohamed
authors: MM
authors: Rashed
authors: Alemayehu
authors: A
authors: Bekele
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000601:surgery; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007047:Hysterosalpingography; D009367:Neoplasm Staging; D010052:Ovariectomy; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor