title: TGF-beta1 promotes migration and invasion of salivary adenoid cystic carcinoma.
abstract: Salivary adenoid cystic carcinoma (SACC) is one of the most common subtypes of salivary gland carcinomas and frequently metastasizes to distant organs. However, little is known about the molecular mechanisms that promote SACC metastasis. In this study, we report that transforming growth factor (TGF)-β1 was highly expressed in the highly metastatic SACC-LM cell line as compared with its parental low-metastatic SACC-83 cell line. Exogenous addition of TGF-β1 induced Smad2 phosphorylation and promoted the migration and invasion of SACC-83 cells. Consistently, the inhibition of endogenous TGF-β1 signaling in SACC-LM cells by an inhibitor specific to the type I TGF-β1 receptor (TβRI) suppressed cell migration and invasion. Moreover, we found that TGF-β1 expression was significantly increased in human primary SACC samples with metastasis. Taken together, our results suggest that TGF-β1 may play a crucial role in SACC metastasis.
authors: Laboratory of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, 22 Zhongguancun Nandajie, Haidian District, Beijing 100081, PR China.
authors: L
authors: L
authors: Dong
authors: Y X
authors: YX
authors: Wang
authors: S L
authors: SL
authors: Li
authors: G Y
authors: GY
authors: Yu
authors: Y H
authors: YH
authors: Gan
authors: D
authors: D
authors: Li
authors: C Y
authors: CY
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism / Q000473:pathology* / Q000556:secondary; D045744:Cell Line, Tumor; D002465:Cell Movement; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010766:Phosphorylation; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction; D051899:Smad2 Protein / Q000378:metabolism; D018709:Statistics, Nonparametric; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis / Q000502:physiology*; D055815:Young Adult
chemical_list: C497782:SMAD2 protein, human; D051899:Smad2 Protein; D053773:Transforming Growth Factor beta1