title: Interaction between antiretroviral drugs and acenocoumarol.
abstract: The authors report a case of an HIV type-1-infected patient concomitantly using highly active antiretroviral therapy and acenocoumarol anticoagulant for secondary prevention of recurrent venous thromboembolism. This is the first report of a possible drug interaction between efavirenz and atazanavir/ritonavir with acenocoumarol and also of the uncomplicated concurrent use of raltegravir with acenocoumarol.
authors: Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. m.welzen@akf.umcn.nl
authors: Marieke E B
authors: ME
authors: Welzen
authors: Guido E L
authors: GE
authors: van den Berk
authors: Raph L
authors: RL
authors: Hamers
authors: David M
authors: DM
authors: Burger
mesh_terms: D000074:Acenocoumarol / Q000627:therapeutic use*; D000480:Alkynes; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use*; D000069446:Atazanavir Sulfate; D048588:Benzoxazines / Q000627:therapeutic use; D003521:Cyclopropanes; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000493:pharmacokinetics / Q000627:therapeutic use; D011725:Pyridines / Q000493:pharmacokinetics / Q000627:therapeutic use; D011760:Pyrrolidinones / Q000493:pharmacokinetics / Q000627:therapeutic use; D000068898:Raltegravir Potassium; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D019438:Ritonavir / Q000493:pharmacokinetics / Q000627:therapeutic use; D020246:Venous Thrombosis / Q000150:complications / Q000188:drug therapy*
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D000925:Anticoagulants; D048588:Benzoxazines; D003521:Cyclopropanes; D009842:Oligopeptides; D011725:Pyridines; D011760:Pyrrolidinones; D018894:Reverse Transcriptase Inhibitors; D000068898:Raltegravir Potassium; D000069446:Atazanavir Sulfate; D000074:Acenocoumarol; C098320:efavirenz; D019438:Ritonavir