title: Genetic polymorphism in the 3'-untranslated region of the E-cadherin gene is associated with risk of different cancers.
abstract: The genetic polymorphisms in E-cadherin gene (CDH1) may affect invasive/metastatic disease development by altering gene transcriptional activity. In this paper, we investigated the effect of 3'-UTR +54C/T polymorphism (rs1801026) in CDH1 gene on the risk and progression of several common cancers. Multiple completely independent case-control analyses of 1081 cancer patients with esophageal squamous cell carcinoma (ESCC), gastric cardiac adenocarcinoma (GCA), non-small-cell lung cancer (NSCLC), and cervical cancer and 1131 control subjects in northern Chinese populations. The results showed that the carriers with T allele were significantly decreased the risk of developing GCA, NSCLC, and cervical cancer, with an adjusted odds ratio of 0.67 (95% CI = 0.48-0.91), 0.68 (95% CI = 0.49-0.92), and 0.66 (95% CI = 0.48-0.92), respectively. There were no association between the frequency of genotype and the clinicopathological features of ESCC, GCA, and NSCLC, but the frequency of T allele was significantly lower in patients of stage III cervical cancer (P = 0.026). These results suggested that the 3'-UTR +54C/T polymorphism in CDH1 may be a marker for genetic susceptibility of cancer.
authors: Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
authors: Yan
authors: Y
authors: Li
authors: Yuanjia
authors: Y
authors: Tang
authors: Rongmiao
authors: R
authors: Zhou
authors: Donglan
authors: D
authors: Sun
authors: Yanan
authors: Y
authors: Duan
authors: Na
authors: N
authors: Wang
authors: Zhifeng
authors: Z
authors: Chen
authors: Nan
authors: N
authors: Shen
mesh_terms: D020413:3' Untranslated Regions; D000230:Adenocarcinoma / Q000235:genetics; D000328:Adult; D000368:Aged; D015820:Cadherins / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; D015820:Cadherins