title: Cyclosporin A--a review on fermentative production, downstream processing and pharmacological applications.
abstract: In present times, the immunosuppressants have gained considerable importance in the world market. Cyclosporin A (CyA) is a cyclic undecapeptide with a variety of biological activities including immunosuppressive, anti-inflammatory, antifungal and antiparasitic properties. CyA is produced by various types of fermentation techniques using Tolypocladium inflatum. In the present review, we discuss the biosynthetic pathway, fermentative production, downstream processing and pharmacological activities of CyA.
authors: Food Engineering and Technology Department, Institute of Chemical Technology, Matunga, Mumbai 400019, India.
authors: Shrikant A
authors: SA
authors: Survase
authors: Lalit D
authors: LD
authors: Kagliwal
authors: Uday S
authors: US
authors: Annapure
authors: Rekha S
authors: RS
authors: Singhal
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001709:Biotechnology / Q000379:methods*; D016572:Cyclosporine / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D005285:Fermentation / Q000187:drug effects*; D006801:Humans; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
chemical_list: D016572:Cyclosporine