title: Laparoscopic salpingo-oophorectomy for ovarian ablation in women with hormone-sensitive breast cancer.
abstract: OBJECTIVE
  To evaluate institutional experiences regarding laparoscopic salpingo-oophorectomy in breast cancer patients and to compare the technique with gonadotropin-releasing hormone (GnRH) analogs among premenopausal women with hormone-sensitive breast cancer.
  
  
  METHODS
  Between 2004 and 2009, 103 women with breast cancer underwent laparoscopic salpingo-oophorectomy at Addenbrooke's Hospital, Cambridge, UK. All relevant medical records-including reasons for salpingo-oophorectomy, peri-operative events, and subsequent follow-up-were reviewed.
  
  
  RESULTS
  In the study period, 3 (2.9%) women experienced a recurrence of breast cancer but none had primary peritoneal/ovarian cancer within a median follow-up interval of 34 months (range, 0-70 months). No operative complications were noted among these women and all of them went home on the day of their operation.
  
  
  CONCLUSIONS
  Laparoscopic salpingo-oophorectomy seems to be a safe, permanent, and cost-effective method of ovarian ablation compared with the use of GnRH analogs. Salpingo-oophorectomy also considerably reduces the risk of subsequent ovarian/fallopian tube malignancy in this high-risk population.
authors: Department of Gynecological Oncology, University Hospital Llandough, Cardiff, UK. krishnayan_haldar@yahoo.com
authors: Krishnayan
authors: K
authors: Haldar
authors: Panagiotis
authors: P
authors: Giamougiannis
authors: Charles
authors: C
authors: Wilson
authors: Robin
authors: R
authors: Crawford
mesh_terms: D055011:Ablation Techniques; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000191:economics / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery*; D003131:Combined Modality Therapy; D003365:Costs and Cost Analysis; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000191:economics / Q000627:therapeutic use; D006801:Humans; D010535:Laparoscopy / Q000191:economics; D008875:Middle Aged; D010052:Ovariectomy / Q000191:economics; D011960:Receptors, Estrogen; D012189:Retrospective Studies; D058994:Salpingectomy / Q000191:economics
chemical_list: D018931:Antineoplastic Agents, Hormonal; D011960:Receptors, Estrogen; D007987:Gonadotropin-Releasing Hormone