title: A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation.
abstract: A novel highly enantioselective two step access to a unit B precursor of cryptophycins in good yields from commercially available starting materials has been developed. The key step is an asymmetric hydrogenation using the commercially available [(COD)Rh-(R,R)-Et-DuPhos]BF(4) catalyst. The synthetic route provides the advantage of less synthetic steps, proceeds with high yields and enantioselectivity, and avoids hazardous reaction conditions.
authors: Bielefeld University, Department of Chemistry, Organic and Bioorganic Chemistry, Universitätsstraße 25, 33615 Bielefeld, Germany.
authors: Benedikt
authors: B
authors: Sammet
authors: Mathilde
authors: M
authors: Brax
authors: Norbert
authors: N
authors: Sewald