title: Amyloid β-induced erythrocytic damage and its attenuation by carotenoids.
abstract: The presence of amyloid β-peptide (Aβ) in human blood has recently been established, and it has been hypothesized that Aβ readily contacts red blood cells (RBC) and oxidatively impairs RBC functions. In this study, we conducted in vitro and in vivo studies, which provide evidence that Aβ induces oxidative injury to RBC by binding to them, causing RBC phospholipid peroxidation and diminishing RBC endogenous carotenoids, especially xanthophylls. This type of damage is likely to injure the vasculature, potentially reducing oxygen delivery to the brain and facilitating Alzheimer's disease (AD). As a preventive strategy, because the Aβ-induced RBC damage could be attenuated by treatment of RBC with xanthophylls, we suggest that xanthophylls may contribute to the prevention of AD.
authors: Food & Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan. nkgw@biochem.tohoku.ac.jp
authors: Kiyotaka
authors: K
authors: Nakagawa
authors: Takehiro
authors: T
authors: Kiko
authors: Taiki
authors: T
authors: Miyazawa
authors: Phumon
authors: P
authors: Sookwong
authors: Tsuyoshi
authors: T
authors: Tsuduki
authors: Akira
authors: A
authors: Satoh
authors: Teruo
authors: T
authors: Miyazawa
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002338:Carotenoids / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005434:Flow Cytometry; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D014975:Lutein / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010446:Peptide Fragments / Q000378:metabolism / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D011485:Protein Binding; D024341:Xanthophylls / Q000494:pharmacology
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D008054:Lipid Peroxides; D010446:Peptide Fragments; D010743:Phospholipids; D024341:Xanthophylls; C078592:amyloid beta-protein (1-40); D002338:Carotenoids; C005948:astaxanthine; D014975:Lutein