title: Perioperative cerebral and somatic oxygenation in neonates with hypoplastic left heart syndrome or transposition of the great arteries.
abstract: OBJECTIVE
  Significant depression in cerebral oxygen saturation has been observed in patients with hypoplastic left heart syndrome (HLHS) undergoing Norwood operations. We monitored cerebral oxygen saturation with near-infrared spectroscopy before and after this procedure. Patients with transposition of great arteries (TGA) before and after arterial switch operation were also studied to elucidate whether post-cardiopulmonary bypass (CPB) changes in cerebral oxygen saturation are related to CPB or hemodynamic alterations inherent in single-ventricle physiology.
  
  
  METHODS
  We monitored 33 patients with HLHS and 20 with TGA 24 hours before and 48 hours after CPB. In addition to cerebral oxygen saturation, routine measurements of oxygen transport and delivery were performed.
  
  
  RESULTS
  Preoperatively, cerebral oxygen saturation was higher in patients with HLHS than with TGA (61% ± 7% vs 56% ± 8%, P = .04). After CPB, cerebral oxygen saturation was markedly depressed in both groups but increased toward end of monitoring (HLHS vs TGA minimal value 42% ± 12% vs 54% ± 11%, P < .001, value 48 hours after CPB 62% ± 7% vs 80% ± 8%, P < .0001). Routine measures of oxygen delivery, such as arterial and central venous oxygen saturations, were similar at minimal cerebral oxygen saturation and 48 hours after CPB.
  
  
  CONCLUSIONS
  Depression of cerebral oxygen saturation is prevalent among neonates with congenital heart disease regardless of whether univentricular or biventricular circulation is present, suggesting that cerebral desaturation is mainly induced by CPB's effect on cerebral blood flow. Routine measures of oxygen delivery fail to indicate cerebral desaturation.
authors: Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany.
authors: Anselm
authors: A
authors: Uebing
authors: Anke K
authors: AK
authors: Furck
authors: Jan H
authors: JH
authors: Hansen
authors: Elisabeth
authors: E
authors: Nufer
authors: Jens
authors: J
authors: Scheewe
authors: Peter
authors: P
authors: Dütschke
authors: Olaf
authors: O
authors: Jung
authors: Hans-Heiner
authors: HH
authors: Kramer
mesh_terms: D001794:Blood Pressure; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D005260:Female; D006439:Hemodynamics; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000097:blood / Q000503:physiopathology*; D007231:Infant, Newborn; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D059035:Perioperative Period; D019265:Spectroscopy, Near-Infrared; D014188:Transposition of Great Vessels / Q000503:physiopathology* / Q000601:surgery
chemical_list: D010100:Oxygen