title: A lectin from Musca domestica pupae stimulates B cell proliferation and enhances IL-12 production via ERK1/2-NF-κB signaling pathways.
abstract: A D-galactose-specific lectin, MW = 40 kDa, had been purified from pupae of Musca domestica (MPL). MPL significantly promoted the proliferation of B cells and enhanced the production of IL-12 in a dose-dependent manner. MPL stimulated IκB-α degradation, NF-κB translocation and ERK1/2 phosphorylation which played an upstream role for NF-кB in MPL-induced B cells. Moreover, MPL regulated cell proliferation and induced IL-12 production through ERK1/2-NF-κB signaling pathway.
authors: Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Ministry of Education, Tianjin, China.
authors: Xiaohong
authors: X
authors: Cao
authors: Yuanyuan
authors: Y
authors: Li
authors: Lihua
authors: L
authors: Hou
authors: Minghui
authors: M
authors: Zhou
authors: Zhuo
authors: Z
authors: Wang
authors: Qi
authors: Q
authors: Cui
authors: Xiaohe
authors: X
authors: Gao
authors: Chunling
authors: C
authors: Wang
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006793:Houseflies / Q000737:chemistry*; D018664:Interleukin-12 / Q000096:biosynthesis*; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D020935:MAP Kinase Signaling System / Q000187:drug effects*; D016328:NF-kappa B / Q000378:metabolism*; D011679:Pupa / Q000737:chemistry; D051381:Rats
chemical_list: D037102:Lectins; D016328:NF-kappa B; D018664:Interleukin-12; D048049:Extracellular Signal-Regulated MAP Kinases