title: Homocysteine and ghrelin link with polcystic ovary syndrome in relation to obesity.
abstract: OBJECTIVE
  Elevated levels of plasma homocysteine and depressed ghrelin levels have been found to be associated with insulin resistance in a number of clinical situations, such as polycystic ovary syndrome. This study was designed to determine the relationship of plasma homocysteine and ghrelin levels with obesity in polycystic ovary syndrome.
  
  
  METHODS
  Forty-four adolescents and young women (24 lean, 20 obese) 16-21 years old with polycystic ovary syndrome and age matched 20 healthy adolescents and young women were participated the study. Fasting samples were collected for serum vitamin B12, folate, plasma total homocysteine and ghrelin levels. Serum levels of follicle-stimulating hormone, luteinizing hormone, dehydroepiandrosterone sulfate, insulin, 17-hydroxyprogesterone, free testosterone, sex-hormone binding globulin were measured. Also, serum concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides were determined. Oral glucose tolerance test was done, and HOMA-IR index was used to define insulin resistance.
  
  
  RESULTS
  Plasma total homocysteine levels were significantly higher in women with polycystic ovary syndrome and their plasma ghrelin levels were depressed compared to control group (P < 0.05). Obese adolescents with polycystic ovary syndrome had more depressed plasma ghrelin levels compared to lean ones (P < 0.05). Homocysteine levels didn't correlate with body mass index, but positively correlated with insulin resistance (P < 0.05).
  
  
  CONCLUSIONS
  Elevated plasma homocysteine levels in polycystic ovary syndrome was independent from obesity. Adversely ghrelin levels were depressed with polycystic ovary syndrome in relation to obesity.
authors: Afyon Kocatepe University, Faculty of Medicine, Department of Pediatrics 03200 Afyonkarahisar, Turkey. tolgasen69@yahoo.com
authors: Tolga
authors: T
authors: Altuğ Şen
authors: Reşit
authors: R
authors: Köken
authors: Adnan
authors: A
authors: Narcı
authors: Mehmet
authors: M
authors: Yılmazer
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D005260:Female; D054439:Ghrelin / Q000097:blood*; D042341:Gonadal Hormones / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D055815:Young Adult
chemical_list: D054439:Ghrelin; D042341:Gonadal Hormones; D006065:Gonadotropins, Pituitary; D006710:Homocysteine