title: Activity-dependent regulation of synaptic vesicle exocytosis and presynaptic short-term plasticity.
abstract: Neuronal firing activity controls protein function and dynamically remodels synaptic efficacy. Exocytosis is triggered and regulated by Ca²+ which enters through voltage-gated Ca²+(CaV) channels and diffuses into the presynaptic terminal accompanying action potential firings. Residual Ca²+ is sensed by Ca²+-binding proteins; among other potential actions, it mediates time- and space-dependent synaptic facilitation and depression via effects on Ca(V)2 channel gating and vesicle replenishment in the readily releasable pool (RRP). Mitochondria are also associated with short-term synaptic plasticity due to a sufficient ATP supply for vesicle mobilization into the RRP. Mitochondria-deficient synapses with impaired anterograde transport of mitochondria in neuronal processes show defects in presynaptic short-term plasticity.
authors: Department of Physiology, Tokyo Medical University, 1-1, Shinjuku-6-chome, Shinjuku-ku, Tokyo 160-8402, Japan. mochida@tokyo-med.ac.jp
authors: Sumiko
authors: S
authors: Mochida
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D017729:Presynaptic Terminals / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology; D013572:Synaptic Vesicles / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D018094:Receptors, Metabotropic Glutamate