title: [Q192R polymorphism of PON-1 gene in type 2 diabetic patients].
abstract: Polymorphism of PON-1 gene in 192 position of amino acid sequence of enzyme paraoxonase 1 was studied. For this research we have used the blood samples of 96 patients with T2DM and 123 healthy habitants of Kharkiv. Frequencies of alleles for the patients (pQ = 0,65, pR = 0,35) and the healthies (PQ = 0,70 and pR = 0,30) did not differentiate meaningfully. Distribution of the genotypes for healthy people does not correspond to Hardy-Weinberg equilibrium, the patients of T2DM have surplus of both homozygotes and shortage of heterozygotes. The risk of illness of T2DM for QQ homozygotes is 1,46-times higher and for QR heterozygotes is two times lower than on the average in the population (2%). The risk of illness of T2DM for RR homozygotes 1,86-times exceeds a middle population risk but is not significant.
authors: M Iu
authors: MIu
authors: Gorshunskaia
authors: Iu I
authors: IuI
authors: Karachentsev
authors: L A
authors: LA
authors: Atramentova
authors: T V
authors: TV
authors: Tyzhnenko
authors: N A
authors: NA
authors: Kravchun
authors: A K
authors: AK
authors: Pocherniaev
authors: V V
authors: VV
authors: Poltorak
mesh_terms: D043303:Aryldialkylphosphatase / Q000235:genetics*; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics*; D004587:Electrophoresis, Agar Gel; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D004247:DNA; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human