title: Control of neuronal network organization by chemical surface functionalization of multi-walled carbon nanotube arrays.
abstract: Carbon nanotube substrates are promising candidates for biological applications and devices. Interfacing of these carbon nanotubes with neurons can be controlled by chemical modifications. In this study, we investigated how chemical surface functionalization of multi-walled carbon nanotube arrays (MWNT-A) influences neuronal adhesion and network organization. Functionalization of MWNT-A dramatically modifies the length of neurite fascicles, cluster inter-connection success rate, and the percentage of neurites that escape from the clusters. We propose that chemical functionalization represents a method of choice for developing applications in which neuronal patterning on MWNT-A substrates is required.
authors: CEA, LETI-Minatec, Grenoble, France.
authors: Jie
authors: J
authors: Liu
authors: Florence
authors: F
authors: Appaix
authors: Olivier
authors: O
authors: Bibari
authors: Gilles
authors: G
authors: Marchand
authors: Alim-Louis
authors: AL
authors: Benabid
authors: Fabien
authors: F
authors: Sauter-Starace
authors: Michel
authors: M
authors: De Waard
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002478:Cells, Cultured; D006624:Hippocampus / Q000166:cytology; D018613:Microscopy, Confocal / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008956:Models, Chemical; D036103:Nanotechnology / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D016501:Neurites / Q000502:physiology; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D012825:Silicon / Q000737:chemistry; D013499:Surface Properties
chemical_list: D037742:Nanotubes, Carbon; D012825:Silicon