title: Development and analysis of an instrument to assess student understanding of foundational concepts before biochemistry coursework.
abstract: Biochemistry is a challenging subject because student learning depends on the application of previously learned concepts from general chemistry and biology to new, biological contexts. This article describes the development of a multiple-choice instrument intended to measure five concepts from general chemistry and three from biology that are considered prerequisite for biochemistry learning. This instrument is specifically designed with a factor structure that includes three multiple-choice items for each of the eight concepts and the most common incorrect ideas that students could have as distractors. It can be used as a pretest to identify students' incorrect ideas about those concepts and to determine if instruction helps students overcome those incorrect ideas when used as a posttest. Results from a confirmatory factor analysis support a very good fit for an eight-factor solution. This manuscript represents a report on the current state of instrument development. We seek to share our methods and instrument design principles with the broader community.
authors: Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA.
authors: Sachel M
authors: SM
authors: Villafañe
authors: Cheryl P
authors: CP
authors: Bailey
authors: Jennifer
authors: J
authors: Loertscher
authors: Vicky
authors: V
authors: Minderhout
authors: Jennifer E
authors: JE
authors: Lewis
mesh_terms: D001671:Biochemistry / Q000193:education*; D001695:Biology / Q000193:education*; D002621:Chemistry / Q000193:education*; D004521:Educational Measurement / Q000379:methods*; D006801:Humans; D013334:Students