title: 8q24.3 and 11q25 chromosomal loci association with low HDL-C in metabolic syndrome.
abstract: BACKGROUND
  High-density lipoprotein cholesterol (HDL-C) levels are low in Iranians. Low HDL-C is the most frequent phenotype in metabolic syndrome (MetS) among the Iranian population (32%). This has been claimed to be related to genetic factors.
  
  
  METHODS
  To investigate possible genes linked to this disorder, 12 microsatellite markers were selected. They were used in 107 families with MetS and low HDL-C to analyse relevant association and linkage signals.
  
  
  RESULTS
  Family-based association tests under the biallelic mode gave many positive association signals. Higher association - after correction for multiple testing - was found to be linked with marker D8S1743 and D11S1304 (P < 0·003). The obtained results suggested evidence for association with regions on chromosome 8, 11 and to a lesser degree on chromosome 16. Nonparametric linkage analysis performed by Merlin software gave no significant correlation for any of the chromosomal regions. By considering only families with positive Nonparametric Logarithm of odds (LOD) scores, higher association can clearly be visible with D16S3096 and D11S934.
  
  
  CONCLUSIONS
  These results suggest that 8q22-24; 11q23-25 and 16q23-24 regions are very likely to contain genes that control HDL-C level in Iranian families with metabolic syndrome.
authors: Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti MC, Tehran, Iran.
authors: Maryam Sadat
authors: MS
authors: Daneshpour
authors: Ahmed
authors: A
authors: Rebai
authors: Massoud
authors: M
authors: Houshmand
authors: Suad
authors: S
authors: Alfadhli
authors: Sirous
authors: S
authors: Zeinali
authors: Mehdi
authors: M
authors: Hedayati
authors: Maryam
authors: M
authors: Zarkesh
authors: Fereidoun
authors: F
authors: Azizi
mesh_terms: D000293:Adolescent; D000328:Adult; D008076:Cholesterol, HDL / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007492:Iran; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL