title: Effects of hemofiltration on liver regeneration after hepatectomy.
abstract: OBJECTIVE
  In modern medicine, blood purification methods are used for a variety of diseases and applications in the field of hepatic disorders. The purpose of this study was to clarify the effects of blood purification on liver regeneration just after hepatectomy.
  
  
  METHODS
  Beagle dogs received 70% hepatectomy and were divided into two groups according to the use (hemofiltration group) or absence (controls) of hemofiltration just after surgery. Levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lecithin-cholesterol acyltransferase (LCAT), hyaluronic acid (HA), hepatocyte growth factor (HGF), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) levels were compared between groups.
  
  
  RESULTS
  The hemofiltration group showed significantly higher AST levels compared with controls (p < 0.05). LCAT and IL-6 levels were significantly lower in the hemofiltration group than in controls (p < 0.05). No significant differences in other parameters were seen between groups.
  
  
  CONCLUSIONS
  Use of hemofiltration as a blood purification method just after major hepatectomy may be harmful to liver regeneration, based on changes in blood factors.
authors: Department of Surgery, Ogori Daiichi General Hospital. etou@ogoridaiichi.jp
authors: Ryuichi
authors: R
authors: Eto
authors: Masaakli
authors: M
authors: Oka
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004285:Dogs; D006440:Hemofiltration; D006498:Hepatectomy; D015850:Interleukin-6 / Q000097:blood; D008111:Liver Function Tests; D008115:Liver Regeneration; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood
chemical_list: D015850:Interleukin-6; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D001219:Aspartate Aminotransferases