title: [Study on transdermal absorption of piperine in Erxiekang plaster].
abstract: OBJECTIVE
  To research the absorbed character of piperine in Erxiekang plaster, and piperine by transdermal absorption was determined.
  
  
  METHODS
  The percutaneous absorption of piperine in vitro at different times was conducted by Franz osmosis and diffusion apparatus as well as high-performance liquid chromatography.
  
  
  RESULTS
  It showed that the piperine through skins of mice gradually increased within the experiment time. After 52 h, the penetration of piperine was 78.51%, and remained basically unchanged.
  
  
  CONCLUSIONS
  The method is reliable, and can be used for Erxiekang plaster of determination of transdermal absorption.
authors: Beijing University of Chinese Medicine, Beijing 100102, China.
authors: Yeli
authors: Y
authors: Gao
authors: Jian
authors: J
authors: Ni
authors: Xingbin
authors: X
authors: Yin
authors: Xiaochun
authors: X
authors: Shen
mesh_terms: D000470:Alkaloids / Q000378:metabolism*; D000818:Animals; D052117:Benzodioxoles / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D010880:Piperidines / Q000378:metabolism*; D053284:Polyunsaturated Alkamides / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012869:Skin Absorption
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; C008922:piperine