title: Response of fetal rat calvarial cells to nanotubular titanium oxide surface.
abstract: This study examined the cell response to a TiO2 nanotubular surface (Ti-NT) for future biomedical applications. The level of cell attachment and spreading at 20 min and 60 min was evaluated by SEM. IL-6 and PGE2 secretion was evaluated by ELISA. In SEM analysis, the Ti-NT surface had more fully spread cells compared to the machined titanium surface (Ti-S). ELISA revealed that the level of IL-6 and PGE2 production was higher on the Ti-NT than on the Ti-S. These results suggest that a surface treatment with a nanotubular TiO2 surface enhances the early osteoblast responses, such as cell spreading and cytokine release, which are important for subsequent cell functions and bone healing in vivo.
authors: Dental Research Institute, School of Dentistry, 2nd Stage of Brain Korea 21 Project for School of Dentistry, Gwang-ju 500-757, Korea.
authors: Jae-Sik
authors: JS
authors: Yang
authors: Mong-Sook
authors: MS
authors: Vang
authors: So-Won
authors: SW
authors: Uhm
authors: Young-Suk
authors: YS
authors: Chung
authors: Kyung-Ku
authors: KK
authors: Lee
authors: Doh-Jae
authors: DJ
authors: Lee
authors: Hyun-Ju
authors: HJ
authors: Chung
authors: Young-Joon
authors: YJ
authors: Kim
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D015232:Dinoprostone / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012886:Skull / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D014025:Titanium / Q000494:pharmacology*
chemical_list: D020099:Coated Materials, Biocompatible; D015850:Interleukin-6; C009495:titanium dioxide; D014025:Titanium; D015232:Dinoprostone