title: Impact of coronary artery calcium scanning on coronary risk factors and downstream testing the EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) prospective randomized trial.
abstract: OBJECTIVE
  We conducted a prospective randomized trial to compare the clinical impact of conventional risk factor modification to that associated with the addition of coronary artery calcium (CAC) scanning.
  
  
  BACKGROUND
  Although CAC scanning predicts cardiac events, its impact on subsequent medical management and coronary artery disease risk is not known.
  
  
  METHODS
  We assigned 2,137 volunteers to groups that either did undergo CAC scanning or did not undergo CAC scanning before risk factor counseling. The primary end point was 4-year change in coronary artery disease risk factors and Framingham Risk Score. We also compared the groups for differences in downstream medical resource utilization.
  
  
  RESULTS
  Compared with the no-scan group, the scan group showed a net favorable change in systolic blood pressure (p = 0.02), low-density lipoprotein cholesterol (p = 0.04), and waist circumference for those with increased abdominal girth (p = 0.01), and tendency to weight loss among overweight subjects (p = 0.07). While there was a mean rise in Framingham Risk Score (FRS) in the no-scan group, FRS remained static in the scan group (0.7 ± 5.1 vs. 0.002 ± 4.9, p = 0.003). Within the scan group, increasing baseline CAC score was associated with a dose-response improvement in systolic and diastolic blood pressure (p < 0.001), total cholesterol (p < 0.001), low-density lipoprotein cholesterol (p < 0.001), triglycerides (p < 0.001), weight (p < 0.001), and Framingham Risk Score (p = 0.003). Downstream medical testing and costs in the scan group were comparable to those of the no-scan group, balanced by lower and higher resource utilization for subjects with normal CAC scans and CAC scores ≥400, respectively.
  
  
  CONCLUSIONS
  Compared with no scanning, randomization to CAC scanning was associated with superior coronary artery disease risk factor control without increasing downstream medical testing. Further study of CAC scanning, including pre-specified treatment recommendations, to assess its impact of cardiovascular outcomes is warranted.
authors: Division of Cardiology, St. Luke's Roosevelt Hospital, New York, NY, USA.
authors: Alan
authors: A
authors: Rozanski
authors: Heidi
authors: H
authors: Gransar
authors: Leslee J
authors: LJ
authors: Shaw
authors: Johanna
authors: J
authors: Kim
authors: Lisa
authors: L
authors: Miranda-Peats
authors: Nathan D
authors: ND
authors: Wong
authors: Jamal S
authors: JS
authors: Rana
authors: Raza
authors: R
authors: Orakzai
authors: Sean W
authors: SW
authors: Hayes
authors: John D
authors: JD
authors: Friedman
authors: Louise E J
authors: LE
authors: Thomson
authors: Donna
authors: D
authors: Polk
authors: James
authors: J
authors: Min
authors: Matthew J
authors: MJ
authors: Budoff
authors: Daniel S
authors: DS
authors: Berman
mesh_terms: D058070:Asymptomatic Diseases; D001794:Blood Pressure; D001835:Body Weight; D002114:Calcinosis / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D005260:Female; D006295:Health Resources / Q000706:statistics & numerical data; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D008055:Lipids