title: Ubiquitination-mediated autophagy against invading bacteria.
abstract: Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.
authors: Department of Genetics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Naonobu
authors: N
authors: Fujita
authors: Tamotsu
authors: T
authors: Yoshimori
mesh_terms: D000818:Animals; D001343:Autophagy; D001419:Bacteria / Q000378:metabolism*; D001424:Bacterial Infections / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D025801:Ubiquitin