title: Immunoproteasome expression is induced in mesial temporal lobe epilepsy.
abstract: Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of homeostatic and inflammatory pathways including the oxidized protein clearance and the self-antigen presentation. In the present study we investigated the immunoproteasome expression in hippocampi and cortex of patients affected by different histopathological forms of pharmaco-resistent mesial temporal lobe epilepsy. We identified a pathology-specific pattern of immunoproteasome expression, which could provide insight into the complex neuroinflammatory pathogenic components of this disease.
authors: Institut für Biochemie, Universitätsmedizin Berlin, Charité, Berlin 13347, Germany. michele.mishto@charite.de
authors: Michele
authors: M
authors: Mishto
authors: Claudia
authors: C
authors: Ligorio
authors: Elena
authors: E
authors: Bellavista
authors: Morena
authors: M
authors: Martucci
authors: Aurelia
authors: A
authors: Santoro
authors: Marco
authors: M
authors: Giulioni
authors: Gianluca
authors: G
authors: Marucci
authors: Claudio
authors: C
authors: Franceschi
mesh_terms: D000328:Adult; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D004833:Epilepsy, Temporal Lobe / Q000276:immunology*; D005260:Female; D006624:Hippocampus / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D046988:Proteasome Endopeptidase Complex / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
chemical_list: C071313:LMP-2 protein; D003546:Cysteine Endopeptidases; C077436:LMP7 protein; C486207:PSME2 protein, human; D046988:Proteasome Endopeptidase Complex