title: Hyperbranched polycarbonate-based multimolecular micelle with enhanced stability and loading efficiency.
abstract: We herein develop a facile catalyst-free method to prepare hyperbranched hydroxyl-enriched aliphatic polycarbonate according to SCROP strategy. PEG-attached multiarm hyperbranched copolymer HEHDO-star-mPEG was further designed. It was found that HEHDO-star-mPEG can self-assemble into supramolecular multimolecular micelles in water. HEHDO-star-mPEG micelle showed excellent stability with respect to micellar size upon dilution, and displayed good cell-biocompatibility. An anticancer drug of doxorubicin with hydrogen-bonding functionality was incorporated into obtained micelles to establish a drug delivery system model. A high drug-loading content as well as sustained release pattern for HEHDO-star-mPEG based delivery system was achieved.
authors: Key Laboratory of Biomedical Polymers (The Ministry of Education), Department of Chemistry, Wuhan University, Wuhan 430072, China.
authors: Wei
authors: W
authors: Su
authors: Xiao-Hua
authors: XH
authors: Luo
authors: Hua-Fen
authors: HF
authors: Wang
authors: Lei
authors: L
authors: Li
authors: Jun
authors: J
authors: Feng
authors: Xian-Zheng
authors: XZ
authors: Zhang
authors: Ren-Xi
authors: RX
authors: Zhuo
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004355:Drug Stability; D006801:Humans; D008823:Micelles; D015394:Molecular Structure; D011076:Polycarboxylate Cement / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D011076:Polycarboxylate Cement; D011108:Polymers; C005506:polycarbonate; D004317:Doxorubicin