title: Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF.
abstract: Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in different environmental conditions could influence age-associated changes in hippocampal tPA expression and BDNF maturation in relation with modifications of their cognitive performances. Our data indicate that maintenance in enriched housing led to a reversal of age-associated decrease in expression of hippocampal tPA. A subsequent increase in the level of mature BDNF and an improvement in emotional and spatial memories were observed. Taken together, these data suggest that the tPA-BDNF axis could play a critical role in the control of cognitive functions influenced both by the age and housing conditions.
authors: INSERM, INSERM U919, SP(2)U, Centre for Imaging-Neuroscience and Applications to Pathologies, GIP CYCERON, University of Caen Basse-Normandie (UCBN), F-14074 Caen Cedex, France.
authors: Pauline
authors: P
authors: Obiang
authors: Eric
authors: E
authors: Maubert
authors: Isabelle
authors: I
authors: Bardou
authors: Olivier
authors: O
authors: Nicole
authors: Séverine
authors: S
authors: Launay
authors: Laurent
authors: L
authors: Bezin
authors: Denis
authors: D
authors: Vivien
authors: Véronique
authors: V
authors: Agin
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001245:Association Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000502:physiology*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D003213:Conditioning, Psychological / Q000502:physiology; D004777:Environment; D005239:Fear / Q000502:physiology; D005260:Female; D006799:Housing, Animal; D008568:Memory / Q000502:physiology; D051379:Mice; D009474:Neurons / Q000502:physiology*; D010959:Tissue Plasminogen Activator / Q000378:metabolism*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D010959:Tissue Plasminogen Activator