title: MicroRNA history: discovery, recent applications, and next frontiers.
abstract: Since 1993, when the first small non-coding RNA was identified, our knowledge about microRNAs has grown exponentially. In this review, we focus on the main progress in this field and discuss the most important findings under a historical perspective. In addition, we examine microRNAs as markers of disease diagnosis and prognosis, and as new therapeutic targets.
authors: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors: Maria I
authors: MI
authors: Almeida
authors: Rui M
authors: RM
authors: Reis
authors: George A
authors: GA
authors: Calin
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000266:history / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics
chemical_list: D015415:Biomarkers; D035683:MicroRNAs