title: [Effects of Tripterygium hypoglaucum on serum IL-1, IL-6, and TNF-alpha in chronic nephritis rats].
abstract: OBJECTIVE
  To investigate the effects and mechanism of Tripterygium hypoglaucum (THH) on serum IL-1, IL-6, and TNF-alpha in chronic, nephritis rats.
  
  
  METHODS
  The rabbit serum of anti-rat kidney was initially prepared, and then injected into normal rats to induce the formation of chronic glomerulonephritis. In this model, THH was administrated for 4 weeks, while saline and prednisone were respectively used as negative and positive controls. Some of laboratory parameters were observed from the rats above.
  
  
  RESULTS
  THH not only significantly decreased urine protein, reduced serum urea nitrogen, but also decreased the releases of inflammatory mediators (such as IL-1, IL-6 and TNF-alpha).
  
  
  CONCLUSIONS
  THH is effective in treating rat nephrotoxic serum glormerulonephritis, its mechanism probably related to decreasing inflammatory mediator levels.
authors: College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. wxb7516@yahoo.com.cn
authors: Xiaobo
authors: X
authors: Wu
authors: Jiahong
authors: J
authors: Xu
authors: Xianqin
authors: X
authors: Luo
mesh_terms: D000818:Animals; D002908:Chronic Disease / Q000188:drug therapy; D005260:Female; D007375:Interleukin-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D009393:Nephritis / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D029757:Tripterygium / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha