title: Presenilins mediate efficient proteolysis via the autophagosome-lysosome system.
abstract: Degradation through the lysosome involves careful orchestration of numerous molecular players in concert. Many of these key molecular players remain to be identified. We find that wild-type presenilins play a key role in degradation through the autophagy-lysosome system by modulating either fusion of autophagosomes to lysosomes or lysosome function.
authors: Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, USA.
authors: Kara M
authors: KM
authors: Neely
authors: Kim N
authors: KN
authors: Green
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001343:Autophagy; D002460:Cell Line; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D008954:Models, Biological; D009154:Mutation; D010447:Peptide Hydrolases / Q000378:metabolism; D010588:Phagosomes / Q000378:metabolism*; D053763:Presenilins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D053763:Presenilins; D010447:Peptide Hydrolases