title: IL-1-polymorphism and severity of periodontal disease.
abstract: OBJECTIVE
  To determine the association between the interleukin (IL)-1-polymorphism and the severity of periodontal disease prior to active periodontal therapy.
  
  
  METHODS
  Two hundred and six patients with obtained baseline x-rays were tested for IL-1-polymorphism. Relative bone loss before active periodontal treatment was measured with a Schei ruler and classified in five groups. Descriptive statistics and backward stepwise linear regression analyses were performed.
  
  
  RESULTS
  Forty-nine patients with moderate (mChP), 79 with severe chronic (sChP) and 78 with aggressive periodontitis (AgP) were included. Age correlated significantly with bone loss and number of teeth at baseline. Gender, smoking and IL-1-polymorphism were neither associated with bone loss nor with number of teeth prior to treatment. After adjusting for age as well as gender, AgP was significantly associated with more severe bone loss in untreated periodontal disease (p = 0.036). In non-smokers, mean number of teeth prior to active periodontal therapy correlated significantly with presence of IL-1 polymorphism.
  
  
  CONCLUSIONS
  The IL-1-polymorphism is associated with lower number of teeth in non-smokers with untreated periodontal disease. Untreated AgP is associated with more severe bone loss than untreated ChP.
authors: Section of Periodontology, Department of Conservative Dentistry, Clinic for Oral, Dental and Maxillofacial Diseases, University Hospital Heidelberg, Germany. bernadette.pretzl@med.uni-heidelberg.de
authors: Bernadette
authors: B
authors: Pretzl
authors: Nihad
authors: N
authors: El Sayed
authors: Raluca
authors: R
authors: Cosgarea
authors: Jens
authors: J
authors: Kaltschmitt
authors: Ti-Sun
authors: TS
authors: Kim
authors: Peter
authors: P
authors: Eickholz
authors: Katrin
authors: K
authors: Nickles
authors: Amelie
authors: A
authors: Bäumer
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000145:classification / Q000235:genetics* / Q000473:pathology; D016301:Alveolar Bone Loss / Q000235:genetics; D055113:Chronic Periodontitis / Q000145:classification / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking; D016388:Tooth Loss / Q000235:genetics
chemical_list: D007375:Interleukin-1