title: A history of the prevalence and control of contagious bovine pleuropneumonia in China.
abstract: Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides small colony type, was once the most damaging infectious animal disease in China, second only to rinderpest. Between 1949 and 1989, 178,570 cattle died of CBPP, causing estimated losses of 356 million RMB (1RMB=approx. £0.094, US$0.15, €0.11 at 27th January 2011). In 1956, in an effort to control the disease, a virulent strain of the causative organism (Ben-1) was attenuated by multiple passages in rabbits. The resultant vaccine achieved a high protection rate in cattle with a duration of immunity of 28 months. Vaccines were also prepared in sheep to increase the antigen yield and then in Tibetan sheep because it caused fewer adverse reactions in yaks and related species. The last CBPP infected animal was identified in 1989 since when no more cases have occurred. In 1992, vaccination of cattle was stopped. In 2008 China submitted an application to the World Organization for Animal Health (OIE) to be declared CBPP-free.
authors: National Contagious Bovine Pleuropneumonia Reference Laboratory, Division of Bacterial Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin 150001, China.
authors: Jiuqing
authors: J
authors: Xin
authors: Yuan
authors: Y
authors: Li
authors: Robin A J
authors: RA
authors: Nicholas
authors: Chao
authors: C
authors: Chen
authors: Yang
authors: Y
authors: Liu
authors: Mei-Jing
authors: MJ
authors: Zhang
authors: Hui
authors: H
authors: Dong
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology* / Q000517:prevention & control*; D002681:China / Q000453:epidemiology; D009176:Mycoplasma mycoides / Q000276:immunology; D011002:Pleuropneumonia, Contagious / Q000453:epidemiology* / Q000517:prevention & control*; D015995:Prevalence; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology* / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary