title: Transgenic rice expressing amyloid β-peptide for oral immunization.
abstract: Various vaccine therapies for Alzheimer's disease (AD) have been investigated. Here we report transgenic rice expressing amyloid β-peptide (Aβ). The Aβ42 gene fused with a green fluorescent protein gene was introduced into rice using the Agrobacterium method. When transgenic brown rice expressing Aβ was orally administered to mice, serum anti-Aβ antibody titers were elevated. The same results were observed when mice were fed boiled, transgenic brown rice. The results indicate that an edible vaccine against AD using rice may be feasible. A vaccine derived from rice would be far cheaper than existing medical vaccines.
authors: National Agricultural Research Center for Tohoku Region, National Agriculture and Food Research Organization, 4 Akahira, Shimo-kuriyagawa, Morioka, Iwate 020-0198, Japan. yoshidat@affrc.go.jp
authors: Taiji
authors: T
authors: Yoshida
authors: Eiichi
authors: E
authors: Kimura
authors: Setsuo
authors: S
authors: Koike
authors: Jun
authors: J
authors: Nojima
authors: Eugene
authors: E
authors: Futai
authors: Noboru
authors: N
authors: Sasagawa
authors: Yuichiro
authors: Y
authors: Watanabe
authors: Shoichi
authors: S
authors: Ishiura
mesh_terms: D016960:Agrobacterium tumefaciens / Q000235:genetics; D000544:Alzheimer Disease / Q000276:immunology*; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use*; D000818:Animals; D000906:Antibodies / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D016233:Immunotherapy, Active / Q000379:methods*; D051379:Mice; D012275:Oryza / Q000235:genetics*; D010446:Peptide Fragments / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use*; D030821:Plants, Genetically Modified / Q000378:metabolism*; D014169:Transformation, Bacterial; D022462:Vaccines, Edible / Q000627:therapeutic use
chemical_list: D016229:Amyloid beta-Peptides; D000906:Antibodies; D010446:Peptide Fragments; D022462:Vaccines, Edible; C075222:amyloid beta-protein (1-42)