title: Inhibitory effects of isolated compounds from black coloured rice bran on the complement classical pathway.
abstract: The present study evaluated the anticomplement effects of isolated compounds from black coloured rice bran in the classical pathway of the complement system. Using column chromatography, three compounds: oryzafuran, quercetin and protocatechuic acid, were isolated and evaluated for in vitro anticomplement activity. Oryzafuran showed the most potent inhibitory activity against the complement system, with 50% inhibitory concentration (IC50) values of 126.2 µg/mL. This is the first report of anticomplement activity of isolated compounds from black coloured rice bran.
authors: Department of Medicinal Biotechnology, College of Natural Resources and Life Science, Dong-A University, Busan, 604-714, South Korea. himun68@dau.ac.kr.
authors: Hyung-In
authors: HI
authors: Moon
authors: Jai-Heon
authors: JH
authors: Lee
authors: Young-Choon
authors: YC
authors: Lee
authors: Soo-Ki
authors: SK
authors: Kim
mesh_terms: D000818:Animals; D003171:Complement Pathway, Classical / Q000187:drug effects*; D004912:Erythrocytes; D062385:Hydroxybenzoates / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D012275:Oryza / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology; D011817:Rabbits; D012756:Sheep
chemical_list: D062385:Hydroxybenzoates; D010936:Plant Extracts; C009091:protocatechuic acid; D011794:Quercetin