title: Endosome-escapable magnetic poly(amino acid) nanoparticles for cancer diagnosis and therapy.
abstract: Endosome-escapable poly(amino acid) nanoparticles composed of iron oxide nanocrystals and anticancer drugs were prepared and demonstrated high T(2) relaxivity coefficients and higher efficacy attributed to the endosomolytic ability of the conjugated histidine moiety.
authors: Department of Chemical and Biomolecular Engineering (BK21 Graduate Program), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
authors: Hee-Man
authors: HM
authors: Yang
authors: Hyun Jin
authors: HJ
authors: Lee
authors: Chan Woo
authors: CW
authors: Park
authors: Se Rim
authors: SR
authors: Yoon
authors: Sujin
authors: S
authors: Lim
authors: Bong Hyun
authors: BH
authors: Jung
authors: Jong-Duk
authors: JD
authors: Kim
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000627:therapeutic use*; D004317:Doxorubicin / Q000737:chemistry*; D011992:Endosomes / Q000737:chemistry* / Q000378:metabolism*; D005290:Ferric Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006639:Histidine / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D053768:Metal Nanoparticles; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D010316:Particle Size
chemical_list: D000596:Amino Acids; D005290:Ferric Compounds; C000499:ferric oxide; D006639:Histidine; D004317:Doxorubicin