title: (99m)Tc-GSA SPECT analysis was clinically useful to evaluate the effect of interferon in a patient with interferon non-responsive chronic hepatitis C.
abstract: We describe a 62-year-old woman with advanced chronic hepatitis C who showed no response to low-dose long-term interferon-beta monotherapy (3 MU, three times a week). The interferon monotherapy was continued for 2 years and 9 months. Despite this lack of response to interferon, the patient's clinical course was good and liver function assessed by (99m)Tc-galactosyl human serum albumin single photon emission computed tomography ((99m)Tc-GSA SPECT) analysis improved significantly. Improvement of the data obtained by (99m)Tc-GSA SPECT analysis justified continuation of the treatment. (99m)Tc-GSA SPECT analysis was clinically useful to evaluate the effect of interferon in a patient with interferon non-responsive chronic hepatitis C, despite a lack of reduction of the ALT level and HCV-RNA titer.
authors: Department of Gastroenterology, Yamagata University, Japan.
authors: Rika
authors: R
authors: Ishii
authors: Hitoshi
authors: H
authors: Togashi
authors: Akiko
authors: A
authors: Iwaba
authors: Chikako
authors: C
authors: Sato
authors: Hiroaki
authors: H
authors: Haga
authors: Mai
authors: M
authors: Sanjo
authors: Kazuo
authors: K
authors: Okumoto
authors: Yuko
authors: Y
authors: Nishise
authors: Jun-Itsu
authors: JI
authors: Ito
authors: Hisayoshi
authors: H
authors: Watanabe
authors: Koji
authors: K
authors: Saito
authors: Akio
authors: A
authors: Okada
authors: Kazuei
authors: K
authors: Takahashi
authors: Takafumi
authors: T
authors: Saito
authors: Sumio
authors: S
authors: Kawata
mesh_terms: D024882:Drug Resistance, Viral; D005260:Female; D019698:Hepatitis C, Chronic / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007372:Interferons / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D007372:Interferons; D016284:Technetium Tc 99m Pentetate