title: Computer-based intervention in HIV clinical care setting improves antiretroviral adherence: the LifeWindows Project.
abstract: We evaluated the efficacy of LifeWindows, a theory-based, computer-administered antiretroviral (ARV) therapy adherence support intervention, delivered to HIV + patients at routine clinical care visits. 594 HIV + adults receiving HIV care at five clinics were randomized to intervention or control arms. Intervention vs. control impact in the intent-to-treat sample (including participants whose ARVs had been entirely discontinued, who infrequently attended care, or infrequently used LifeWindows) did not reach significance. Intervention impact in the On Protocol sample (328 intervention and control arm participants whose ARVs were not discontinued, who attended care and were exposed to LifeWindows regularly) was significant. On Protocol intervention vs. control participants achieved significantly higher levels of perfect 3-day ACTG-assessed adherence over time, with sensitivity analyses maintaining this effect down to 70% adherence. This study supports the utility of LifeWindows and illustrates that patients on ARVs who persist in care at clinical care sites can benefit from adherence promotion software.
authors: Department of Psychology, University of Connecticut, Storrs, USA. jeffrey.fisher@uconn.edu
authors: Jeffrey D
authors: JD
authors: Fisher
authors: K Rivet
authors: KR
authors: Amico
authors: William A
authors: WA
authors: Fisher
authors: Deborah H
authors: DH
authors: Cornman
authors: Paul A
authors: PA
authors: Shuper
authors: Cynthia
authors: C
authors: Trayling
authors: Caroline
authors: C
authors: Redding
authors: William
authors: W
authors: Barta
authors: Anthony F
authors: AF
authors: Lemieux
authors: Frederick L
authors: FL
authors: Altice
authors: Kevin
authors: K
authors: Dieckhaus
authors: Gerald
authors: G
authors: Friedland
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D003201:Computers; D003237:Connecticut; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010353:Patient Education as Topic; D012984:Software; D014584:User-Computer Interface; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents