title: Synthesis of arrays using low molecular weight MPEG-assisted Mitsunobu reaction.
abstract: Triphenylphosphine tagged with a short poly-(ethyleneglycol)-ω-monomethyl ether chain (light MPEG, 10−16 ethylenoxy units, (M)TPP-G2) and an MPEG-tagged version of diethyl azodicarboxylate ((M)DEAD) have been used to prepare a 20 member library of esters, ethers, and sulfonamides, with cLogP's in the range of 1.4−5.7 on a 0.1 mmol scale. Removal of MPEG-tagged side products was achieved by MPEG-assisted solid-phase extraction (MSPE) on prepacked silica columns to give the products in good yield and high purity.
authors: WestCHEM Department of Chemistry, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
authors: Marek
authors: M
authors: Figlus
authors: Natalie
authors: N
authors: Wellaway
authors: Anthony W J
authors: AW
authors: Cooper
authors: Steven L
authors: SL
authors: Sollis
authors: Richard C
authors: RC
authors: Hartley
mesh_terms: D020650:Combinatorial Chemistry Techniques; D008970:Molecular Weight; D052616:Solid Phase Extraction