title: Molecular imaging and depth profiling by mass spectrometry--SIMS, MALDI or DESI?
abstract: The possibility of exploiting the analytical power of mass spectrometry to image the chemistry of biological and similarly complex materials without the use of tags and with good spatial resolution is seductive. The status, strengths, weaknesses and complementarity of the three main techniques are briefly reviewed and assessed.
authors: Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK. John.Vickerman@manchester.ac.uk
authors: John C
authors: JC
authors: Vickerman
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D008297:Male; D013058:Mass Spectrometry / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D009930:Organic Chemicals / Q000737:chemistry; D011467:Prostate / Q000033:anatomy & histology; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D018629:Spectrometry, Mass, Secondary Ion / Q000379:methods
chemical_list: D009930:Organic Chemicals; D011506:Proteins