title: Subcutaneous calcification of the lower legs in a patient with mixed connective tissue disease.
abstract: A 56-year-old woman who had been treated for mixed connective tissue disease (MCTD) noticed a skin ulcer on the lower leg. There was no history of trauma. X-rays of the lower legs showed extensive calcification in the soft tissue. Biopsied tissue from the ulcer showed marked calcium deposition with necrosis. Laboratory findings revealed normal serum calcium and phosphate levels and normal parathyroid function. On the basis of these findings, we diagnosed skin ulcer due to subcutaneous dystrophic calcification associated with MCTD. The ulcer was gradually reduced in size and epithelialized by treatment with local debridement and antibiotics.
authors: Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. kazuhiko@dermatol.med.kyushu-u.ac.jp
authors: Kazuhiko
authors: K
authors: Yamamura
authors: Masakazu
authors: M
authors: Takahara
authors: Kana
authors: K
authors: Masunaga
authors: Takuya
authors: T
authors: Sawabe
authors: Masaki
authors: M
authors: Kitano
authors: Toshihiko
authors: T
authors: Mashino
authors: Masutaka
authors: M
authors: Furue
mesh_terms: D002114:Calcinosis / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D007866:Leg; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000473:pathology*; D012883:Skin Ulcer / Q000209:etiology / Q000473:pathology / Q000628:therapy