title: Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression.
abstract: During mitosis, cells segregate duplicated chromosomes with high fidelity in order to maintain genome stability. Proper attachment of sister kinetochores to spindle microtubules is critical for accurate chromosome segregation and is driven by complex mechanisms that promote the capture of unattached kinetochores and the resolution of erroneously attached kinetochores. Defects in these surveillance systems promote chromosome segregation and aneuploidy and can contribute to neoplastic transformation. Understanding, how, at the molecular level, accurate chromosome segregation is achieved may be crucial for our understanding of how cancer cells develop genome instability.
authors: Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.
authors: Robin M
authors: RM
authors: Ricke
authors: Jan M
authors: JM
authors: van Deursen
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000782:Aneuploidy; D000818:Animals; D064127:Aurora Kinases; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D020090:Chromosome Segregation; D042822:Genomic Instability; D006801:Humans; D018386:Kinetochores / Q000378:metabolism; D059566:M Phase Cell Cycle Checkpoints / Q000502:physiology*; D051379:Mice; D008870:Microtubules / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D008941:Spindle Apparatus / Q000235:genetics / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000235:genetics / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases