title: Natural history of multiple sclerosis: long-term prognostic factors.
abstract: Several prognostic factors of long-term irreversible disability, mainly demographic and clinical, have been described in multiple sclerosis (MS). Most predictors have a minor influence on the long-term prognosis, and efforts are currently shifting toward finding relevant paraclinical predictors. By contrast, the study of prognostic factors has given some insights into the pathogenesis of MS, notably regarding the relation between relapses and long-term disability, and has emphasized the need to elucidate the exact mechanisms underlying neurodegeneration for the development of new therapeutic targets.
authors: Center for Clinical Epidemiology, Jewish General Hospital, McGill University, 3755 Cote Ste-Catherine, H464, Montreal, QC H3T 1E2, Canada. christel.renoux@mail.mcgill.ca
authors: Christel
authors: C
authors: Renoux
mesh_terms: D017668:Age of Onset; D004185:Disability Evaluation; D018450:Disease Progression; D004777:Environment; D006801:Humans; D008137:Longitudinal Studies; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D011379:Prognosis