title: Determination of serotonin on a glassy carbon electrode modified by electropolymerization of meso-tetrakis(2-aminophenyl)porphyrin and single walled carbon nanotubes.
abstract: A chemically modified electrode [poly(TAPP)-SWNT/GCE] was prepared by electropolymerization of meso-tetrakis(2-aminophenyl)porphyrin (TAPP)-single walled carbon nanotubes (SWNT) on the surface of a glassy carbon electrode (GCE). This modified electrode was employed as an electrochemical biosensor for the determination of serotonin concentration and exhibited a typical enhance effect on the current response of serotonin and lower oxidation overpotential. The biosensor was very effective to determined 5-HT in a mixture. The linear response was in the range 2.0 x 10(-7) to 1.0 x 10(-5) M, with a correlation coefficient of 0.999 [i(p)(microA) = 3.406 C (microM)+0.132] on the anodic current, with a detection limit of 1 x 10(-9) M. Due to the relatively low currents and different potentials in the electrochemical responses to ascorbic acid and dopamine, the modified electrode is a useful and effective sensing device for the selective and sensitive serotonin determination in the presence of ascorbic acid and dopamine.
authors: Department of Chemistry and Institute of Basic Science, Chonnam National University, Gwangju 500-757, Korea.
authors: Seul Ki
authors: SK
authors: Kim
authors: Mohammad Shamsuddin
authors: MS
authors: Ahmed
authors: Haesang
authors: H
authors: Jeong
authors: Jung-Min
authors: JM
authors: You
authors: Seungwon
authors: S
authors: Jeon
mesh_terms: D045424:Complex Mixtures / Q000032:analysis; D003217:Conductometry / Q000295:instrumentation*; D003460:Crystallization / Q000379:methods; D004566:Electrodes; D004595:Electroplating / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005898:Glass / Q000737:chemistry; D036103:Nanotechnology / Q000295:instrumentation*; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011166:Porphyrins / Q000737:chemistry*; D012701:Serotonin / Q000032:analysis*
chemical_list: D045424:Complex Mixtures; D037742:Nanotubes, Carbon; D011166:Porphyrins; D012701:Serotonin