title: Precise positioning of chiral building blocks in monodisperse, sequence-defined polyamides.
abstract: The synthesis of monodisperse polymers with a defined monomer sequence is a new challenge in polymer chemistry. Recently, we introduced a novel synthetic strategy towards monodisperse, sequence-defined poly(amidoamine)s based on the stepwise assembly of diamine and diacid building blocks on a solid support. Here we introduce the first chiral building block suitable for the automated poly(amidoamine) synthesis. The synthetic strategy utilizes natural amino acids as starting materials, thus providing a variety of chiral building blocks with different functionalities in the side chain. As a first chiral monomer, L-alanine is transformed into a mono Fmoc-protected diamine building block and successfully introduced into poly(amide) segments.
authors: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Arnimallee 22, 14195 Berlin, Germany.
authors: Simone
authors: S
authors: Mosca
authors: Felix
authors: F
authors: Wojcik
authors: Laura
authors: L
authors: Hartmann
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D015394:Molecular Structure; D009757:Nylons / Q000138:chemical synthesis*; D060327:Solid-Phase Synthesis Techniques / Q000379:methods; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D009757:Nylons