title: Update on treatment of childhood bronchiectasis unrelated to cystic-fibrosis.
abstract: There are multiple aetiologies for childhood bronchiectasis unrelated to cystic fibrosis. Some of these aetiologies, such as those predisposing to recurrent lung infections, e.g. immunodeficiencies, require treatment of the underlying condition and disease-specific pulmonary pathogens within the airway. Regardless of aetiology, the treatments for bronchiectasis include antibiotics, airway clearance regimens, immunizations to prevent infections, and in some cases asthma therapies. The grade of evidence for specific treatments is low with few randomized controlled trials in children. Extrapolations of care provided to adults with bronchiectasis and patients with cystic fibrosis may not always be justified. Comprehensive care programs for children with bronchiectasis have demonstrated clinically relevant improvements over 2-7 year periods. Multi-center research is needed to rigorously evaluate current treatment practices for children with this disorder.
authors: Professor of Pediatrics, University of Washington School of Medicine, Chief, Pulmonary and Sleep Medicine Division, Seattle Children's Hospital, Seattle, Washington, USA. gredding@u.washington.edu
authors: Gregory J
authors: GJ
authors: Redding
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001987:Bronchiectasis / Q000188:drug therapy / Q000209:etiology* / Q000628:therapy*; D003550:Cystic Fibrosis / Q000150:complications*; D006801:Humans; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents