title: Transcutaneous focal electrical stimulation via concentric ring electrodes reduces synchrony induced by pentylenetetrazole in beta and gamma bands in rats.
abstract: Epilepsy is a neurological disorder that affects approximately one percent of the world population. Anti-epileptic drugs are ineffective in 25~30% of cases. Electrical stimulation to control seizures may be an additive therapy. We applied noninvasive transcutaneous focal electrical stimulation (TFES) via concentric ring electrodes on the scalp of rats after inducing seizures with pentylenetetrazole. We found a significant increase in synchrony within the beta-gamma bands during seizures and that TFES significantly reduced the synchrony of the beta-gamma activity and increased synchrony in the delta band.
authors: Electrical, Computer, and Biomedical Engineering, University of Rhode Island, 4 East Alumni Ave., Kingston, Rhode Island 02881, USA. besio@ele.uri.edu
authors: Walter G
authors: WG
authors: Besio
authors: Xiang
authors: X
authors: Liu
authors: Liling
authors: L
authors: Wang
authors: Andrei V
authors: AV
authors: Medvedev
authors: Kanthaiah
authors: K
authors: Koka
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D004566:Electrodes; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D004561:Transcutaneous Electric Nerve Stimulation / Q000295:instrumentation*
chemical_list: D010433:Pentylenetetrazole