title: Pedunculopontine stimulation from primate to patient.
abstract: Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.
authors: Oxford Functional Neurosurgery, Department of Neurological Surgery, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK. eacp@eacp.co.uk
authors: Erlick A C
authors: EA
authors: Pereira
authors: Dipankar
authors: D
authors: Nandi
authors: Ned
authors: N
authors: Jenkinson
authors: John F
authors: JF
authors: Stein
authors: Alexander L
authors: AL
authors: Green
authors: Tipu Z
authors: TZ
authors: Aziz
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001703:Biophysics; D003292:Convulsants / Q000494:pharmacology; D046690:Deep Brain Stimulation / Q000266:history / Q000379:methods*; D004195:Disease Models, Animal; D058785:GABA-A Receptor Agonists / Q000627:therapeutic use; D049673:History, 20th Century; D006801:Humans; D008251:Macaca; D008297:Male; D009118:Muscimol / Q000627:therapeutic use; D010300:Parkinson Disease / Q000209:etiology / Q000628:therapy; D045042:Pedunculopontine Tegmental Nucleus / Q000502:physiology*
chemical_list: D003292:Convulsants; D058785:GABA-A Receptor Agonists; D009118:Muscimol; D001640:Bicuculline