title: Long-term survival of a patient with multiple abdominal metastasis from endometrial carcinoma treated with multi-portal conformal re-irradiation and chemotherapy.
abstract: A patient with recurrent endometrial cancer with multiple abdominal and pelvic tumoral masses was treated with re-irradiation combined with liposomal doxorubicin and oxaliplatin. A multiple field conformal technique was used to deliver a highly accelerated and hypofractionated scheme (15 fractions of 3.5 Gy, within 19 days). Complete response was confirmed four months after therapy. Four years later a lung metastasis appeared and was again treated with a similar course of therapy, once again resulting in a complete response. It is suggested that in the era of modern image-guided radiotherapy patients with endometrial cancer who have relapsed within or outside the loco-regional area, should be carefully assessed for an eventual gross tumor eradication using high-dose localized radiotherapy, leaving as the only target of chemotherapy the microscopic undetectable disease.
authors: Department of Radiotherapy and Oncology, Democritus University of Thrace, Dragana, Alexandroupolis, Greece. targ@her.forthnet.gr
authors: M I
authors: MI
authors: Koukourakis
authors: A
authors: A
authors: Papadopoulou
authors: G
authors: G
authors: Kyrgias
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary*; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D020266:Radiotherapy, Conformal; D016019:Survival Analysis; D013997:Time Factors; D014057:Tomography, X-Ray Computed