title: Fetal intraperitoneal injection of immunoglobulin diminishes alloimmune hemolysis.
abstract: We report a case of severe fetal anemia associated with maternal anti-M antibody that was treated by direct injection of pooled human immunoglobulin into the fetal abdominal cavity. Four treatments at a dosage of 2 g per-kg estimated fetal body weight were performed, and no side effects were observed. A healthy baby girl was delivered transvaginally at 38 weeks, with neither exchange transfusion nor phototherapy required. Follow-up over 12 months found no indications of anemia or developmental delay in the child. This is believed to be the first report of fetal anemia in a blood-type-incompatible pregnancy being treated successfully with only direct immunoglobulin injection into the fetus. The immunoglobulin may have functioned as a neutralizing antibody causing the anemia to improve.
authors: Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan. hmatsuda@ndmc.ac.jp
authors: H
authors: H
authors: Matsuda
authors: M
authors: M
authors: Yoshida
authors: H
authors: H
authors: Wakamatsu
authors: K
authors: K
authors: Furuya
mesh_terms: D000743:Anemia, Hemolytic / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D000906:Antibodies / Q000097:blood; D001787:Blood Group Incompatibility / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D017218:Cordocentesis; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D005323:Fetal Monitoring; D046128:Fetal Therapies; D005333:Fetus / Q000276:immunology / Q000503:physiopathology; D054502:Histocompatibility, Maternal-Fetal / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage / Q000009:adverse effects; D007223:Infant; D007231:Infant, Newborn; D007274:Injections, Intraperitoneal; D011247:Pregnancy; D011256:Pregnancy Outcome; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000906:Antibodies; D007136:Immunoglobulins