title: [T cell receptor BV gene preferential usage in oral lichen planus].
abstract: OBJECTIVE
  To identify the T cell receptor (TCR) structural characteristics of infiltrating T cells derived from the lesional tissues of oral lichen planus (OLP) patients.
  
  
  METHODS
  BV gene distribution analysis was performed quantitatively in OLP patients using real-time polymerase chain reaction. The data was analyzed by Mann-Whitney U test using GraphPad Prism version 5.00 software.
  
  
  RESULTS
  The usage toward BV4, BV14 and BV18 in the lesional tissues from 43 OLP patients was significantly higher than the usage toward these BV genes in the peripheral blood from 39 OLP patients.
  
  
  CONCLUSIONS
  Infiltrating T cells derived from the lesional tissues in a cohort of Chinese OLP patients display preferential usage toward BV4, BV14 and BV18. It indicates that the T cells bearing BV4, BV14 and BV18 genes play a very important role in the etiology and pathogenesis of OLP. Supported by National Natural Science Foundation of China (30872888), Research Fund of Science and Technology Commission of Shanghai Municipality (06ZR14060) and Shanghai Leading Academic Discipline Project (S30206).
authors: Department of Oral Medicine, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China. leoh.yao@gmail.com
authors: Hui
authors: H
authors: Yao
authors: Hui-yuan
authors: HY
authors: Li
authors: Yong-mei
authors: YM
authors: Zhou
authors: Xue-min
authors: XM
authors: Shen
authors: Guo-yao
authors: GY
authors: Tang
mesh_terms: D006801:Humans; D017676:Lichen Planus, Oral; D011948:Receptors, Antigen, T-Cell; D013601:T-Lymphocytes
chemical_list: D011948:Receptors, Antigen, T-Cell