title: Intravenous ascorbic acid (vitamin C) administration in myomectomy: a prospective, randomized, clinical trial.
abstract: BACKGROUND
  To assess the usefulness of using ascorbic acid (vitamin C) administration in abdominal myomectomy.
  
  
  METHODS
  A total of 102 patients were divided two groups in this prospective, clinical trial. Group A had received 2 g of ascorbic acid during a myomectomy, and group B had a myomectomy without any interventions. The operative time, blood loss, days of hospitalization, post-operative complications and rate of blood transfusions were compared between the two groups.
  
  
  RESULTS
  The blood loss (521.44 ± 199.24 vs. 932.9 ± 264.38 ml; p value <0.001), duration of the operation time (42 ± 13.9 vs. 68 ± 21.7 min; p value <0.001), days of hospitalization (2.7 ± 0.69 vs. 3.1 ± 0.59 days; p value 0.002) in group A were significantly less than in group B (p value 0.001). The chance risk ratio of a blood transfusion in group A was 0.4 (7.7 vs. 18% 95% CI of 0.1-1; p value 0.07). There was a significant correlation between the volume of bleeding and post-operative complications in both groups (p value in group A = 0.03; in group B = 0.004).
  
  
  CONCLUSIONS
  The administration of ascorbic acid (vitamin C) in abdominal myomectomy could reduce the blood loss during the procedure, operation time and days of hospitalization.
authors: Obstetrics and Gynecology Department, Emam Khomeini Hospital, Ahwaz Jundishapur University of Medical Science (AJUMS), Azadegan Street, Ahvaz, Iran. e.pourmatroud@yahoo.com
authors: Elham
authors: E
authors: Pourmatroud
authors: Leila
authors: L
authors: Hormozi
authors: Masoud
authors: M
authors: Hemadi
authors: Roza
authors: R
authors: Golshahi
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006760:Hospitalization; D006801:Humans; D007262:Infusions, Intravenous; D007889:Leiomyoma / Q000601:surgery*; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control; D014594:Uterine Neoplasms / Q000601:surgery*
chemical_list: D000975:Antioxidants; D001205:Ascorbic Acid