title: Cognitive and neural determinants of response strategy in the dual-solution plus-maze task.
abstract: Response strategy in the dual-solution plus maze is regarded as a form of stimulus-response learning. In this study, by using an outcome devaluation procedure, we show that it can be based on both action-outcome and stimulus-response habit learning, depending on the amount of training that the animals receive. Furthermore, we show that deactivation of the dorso-medial and the dorso-lateral striatum with Botulinum neurotoxin A, mimicked or abolished, respectively, the effects of practice on the sensitivity of the response strategy to outcome devaluation. These findings have relevant implications for the understanding of the learning mechanisms underlying different overt behaviors in this widely used maze task.
authors: Dipartimento di Biologia e Biotecnologie, Università degli Studi di Roma La Sapienza, 00185 Rome, Italy. deleonibus@igb.cnr.it
authors: Elvira
authors: E
authors: De Leonibus
authors: Vivian J A
authors: VJ
authors: Costantini
authors: Antonio
authors: A
authors: Massaro
authors: Georgia
authors: G
authors: Mandolesi
authors: Valentina
authors: V
authors: Vanni
authors: Siro
authors: S
authors: Luvisetto
authors: Flaminia
authors: F
authors: Pavone
authors: Alberto
authors: A
authors: Oliverio
authors: Andrea
authors: A
authors: Mele
mesh_terms: D000818:Animals; D019274:Botulinum Toxins, Type A / Q000494:pharmacology; D016009:Chi-Square Distribution; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D003342:Corpus Striatum / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D005508:Food Deprivation / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D009465:Neuromuscular Agents / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012201:Reward; D050825:Synaptosomal-Associated Protein 25 / Q000378:metabolism; D013997:Time Factors
chemical_list: D009465:Neuromuscular Agents; D050825:Synaptosomal-Associated Protein 25; D019274:Botulinum Toxins, Type A