title: Genetic contribution to the relationship between social role function and depressive symptoms in Japanese elderly twins: a twin study.
abstract: BACKGROUND
  Social role function is the capacity to maintain interpersonal relationships and is essential for being independent in the community. Limitations in social role function often coexist with depressive symptoms, suggesting a possible common mechanistic basis. We investigated whether the observed association between these traits is mainly a result of genetic or environmental influences.
  
  
  METHODS
  In 2008, a questionnaire was sent to 745 male twins aged 65 years and older. Our sample included 397 male twins. The number of monozygotic twins was 302, and dizygotic was 95. Among the twin pairs for whom data were available for both twins, 75 twin pairs (150 individuals) were monozygotic and 28 pairs (56 individuals) were dizygotic. Social role function was assessed using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Depressive symptoms were measured by the 15-item version of the Geriatric Depression Scale. Relative importance of genes and environments for the phenotypes was calculated using structural equation analyses.
  
  
  RESULTS
  Our results show that genetic influence was the major contributor to the relationship between social role function and depressive symptoms, and non-shared environmental influence was important for overall variation in each trait.
  
  
  CONCLUSIONS
  We concluded that focusing on a non-shared environment is an essential approach for maintaining social role function and psychological well-being. It is suggested that treatments specific to depressive symptoms are more effective than indirect intervention targeting social role function.
authors: Department of Health Promotion Science, Graduate School of Medicine, Osaka University, Japan. nisihara@sahs.med.osaka-u.ac.jp
authors: Reiko
authors: R
authors: Nishihara
authors: Fujio
authors: F
authors: Inui
authors: Kenji
authors: K
authors: Kato
authors: Rie
authors: R
authors: Tomizawa
authors: Kazuo
authors: K
authors: Hayakawa
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003863:Depression / Q000453:epidemiology* / Q000235:genetics* / Q000523:psychology; D004200:Diseases in Twins / Q000453:epidemiology* / Q000235:genetics* / Q000523:psychology; D005824:Genetics, Behavioral; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D012380:Role; D012944:Social Support; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic