title: Pulsed magneto-motive ultrasound imaging using ultrasmall magnetic nanoprobes.
abstract: Nano-sized particles are widely regarded as a tool to study biologic events at the cellular and molecular levels. However, only some imaging modalities can visualize interaction between nanoparticles and living cells. We present a new technique, pulsed magneto-motive ultrasound imaging, which is capable of in vivo imaging of magnetic nanoparticles in real time and at sufficient depth. In pulsed magneto-motive ultrasound imaging, an external high-strength pulsed magnetic field is applied to induce the motion within the magnetically labeled tissue and ultrasound is used to detect the induced internal tissue motion. Our experiments demonstrated a sufficient contrast between normal and iron-laden cells labeled with ultrasmall magnetic nanoparticles. Therefore, pulsed magneto-motive ultrasound imaging could become an imaging tool capable of detecting magnetic nanoparticles and characterizing the cellular and molecular composition of deep-lying structures.
authors: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
authors: Mohammad
authors: M
authors: Mehrmohammadi
authors: Junghwan
authors: J
authors: Oh
authors: Srivalleesha
authors: S
authors: Mallidi
authors: Stanislav Y
authors: SY
authors: Emelianov
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D005290:Ferric Compounds / Q000494:pharmacology; D008027:Light; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D008280:Magnetics / Q000379:methods*; D051379:Mice; D015335:Molecular Probes; D053758:Nanoparticles / Q000648:ultrastructure; D012542:Scattering, Radiation; D014465:Ultrasonics / Q000379:methods*
chemical_list: D005290:Ferric Compounds; D015335:Molecular Probes