title: Metallacycle-Mediated Cross-Coupling with Substituted and Electronically Unactivated Alkenes.
abstract: This perspective surveys the history of- and recent advances in- metallacycle-mediated coupling chemistry of substituted alkenes. While the reaction of preformed metal-π complexes with ethylene was reported nearly 30 years ago, the generalization of this mode of bimolecular C-C bond formation to the regio- and stereoselective union of complex substrates has only recently begun to emerge. This perspective discusses early observations in this area, the challenges associated with controlling such processes, the evolution of a general strategy to overcome these challenges, and a summary of highly regio- and stereoselective convergent coupling reactions that are currently available by metallacycle-mediated cross-coupling with substituted alkenes.
authors: The Department of Chemistry, The Scripps Research Institute; Scripps-Florida, 130 Scripps Way #3A2, Jupiter, FL 33418, USA. ; Tel: 561 228 2463; micalizio@scripps.edu.
authors: Holly A
authors: HA
authors: Reichard
authors: Glenn C
authors: GC
authors: Micalizio