title: The cyclins: a family of widely expressed tumor antigens?
abstract: Continuous cell division is a hallmark of cancer and cell-cycle regulators therefore represent relevant target molecules for tumor therapy. Among these targets the cyclins are of particular interest as they are overexpressed in various tumor entities with little expression in normal tissue. Here we review evidence that these molecules are recognized by the immune system, summarize why cyclins A, B and D in particular appear to be interesting targets for active and passive immunotherapy, and discuss whether the entire family could be an interesting novel class of tumor antigens for cancer treatment and prevention.
authors: Laboratory for Tumor and Transplantation Immunology, Department I of Internal Medicine, University Hospital of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany.
authors: Michael S
authors: MS
authors: von Bergwelt-Baildon
authors: Eisei
authors: E
authors: Kondo
authors: Nela
authors: N
authors: Klein-González
authors: Clemens M
authors: CM
authors: Wendtner
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology* / Q000378:metabolism; D019496:Cancer Vaccines / Q000276:immunology; D002453:Cell Cycle; D002455:Cell Division; D002986:Clinical Trials as Topic; D016213:Cyclins / Q000276:immunology* / Q000378:metabolism; D018984:Epitopes, T-Lymphocyte; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D016213:Cyclins; D018984:Epitopes, T-Lymphocyte