title: Brachial-ankle pulse wave velocity is an independent predictor of incident hypertension in Japanese normotensive male subjects.
abstract: OBJECTIVE
  Cardiovascular morbidity and mortality are closely associated with hypertension, however, predictors of incident hypertension have not been fully established. We have conducted a study aimed at evaluating whether brachial-ankle pulse wave velocity (baPWV) is a predictor of incident hypertension.
  
  
  METHODS
  The relation between baPWV, a noninvasive index of aortic stiffness, and incident hypertension was evaluated in a cohort of 2278 Japanese normotensive male subjects with a follow-up of 3 years.
  
  
  RESULTS
  Of the 2278 study participants, 151 (6.6%) had incident hypertension during the follow-up. After adjustment for variables, including age, gender, body mass index (BMI), smoking habit, alcohol consumption, diabetes mellitus, hyperlipidemia, family history of hypertension, heart rate, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, and fasting plasma glucose, multiple logistic regression analysis revealed that baPWV was a significant and independent predictor of incident hypertension with an adjusted odds ratio 1.45 (95% confidence interval 1.17-1.79, P < 0.01). In addition, baPWV values >1380 cm/s indicated a high risk for incident hypertension.
  
  
  CONCLUSIONS
  Among the Japanese normotensive male subjects participating in this study, BaPWV was a significant and independent predictor of incident hypertension. This result suggests that BaPWV could be a useful screening method to identify normotensive individuals who should be targeted for interventions aimed at preventing the incident hypertension.
authors: Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan. h-satoh@imb.me-h.ne.jp
authors: Hiroki
authors: H
authors: Satoh
authors: Yasuaki
authors: Y
authors: Saijo
authors: Reiko
authors: R
authors: Kishi
authors: Hiroyuki
authors: H
authors: Tsutsui
mesh_terms: D000328:Adult; D055109:Ankle Brachial Index / Q000379:methods* / Q000592:standards; D001794:Blood Pressure; D001916:Brachial Artery / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000503:physiopathology; D007564:Japan; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012016:Reference Values; D011795:Surveys and Questionnaires; D016909:Tibial Arteries / Q000503:physiopathology