title: De novo fatty liver due to vascular complications after liver transplantation.
abstract: BACKGROUND
  The incidence, risk factors, and natural history of de novo nonalcoholic fatty liver disease (NAFLD) after liver transplantation have not been well described. In this report we examined the risk factors and demographic characteristics of 3 patients.
  
  
  METHODS
  During a 16-year period, we performed 900 liver transplantations. We reviewed donor and recipient liver biopsies to identify patients who developed de novo fatty liver following liver transplantation, recording the pretransplantation and posttransplantation blood sugar values and lipid profiles as well as body mass indices (BMI) of affected patients.
  
  
  RESULTS
  Three patients developed de novo fatty liver after transplantation. The primary liver diseases among these patients were as follows: Crigler-Najjar syndrome, biliary atresia, and tyrosinemia. All of the patients who developed NAFLD were children. None of them had obesity; all had normal blood sugar values and lipid profiles (triglyceride cholesterol) at the time of and after the operation. Two patients received liver allografts from living related donors and 1 from a deceased donor. The BMI, lipid profile, and blood sugars of all donors were normal. Preoperative donor liver biopsy specimens showed normal histological findings with no evidence of a fatty liver, but the postoperative liver biopsy in recipients specimens revealed steatosis and fatty liver (20%-40% fat). Portal vein thrombosis and hepatic artery thrombosis were observed in the patients using color Doppler sonography.
  
  
  CONCLUSIONS
  De novo NAFLD after liver transplantation occurred less frequently than noted in previous reports. All 3 patients experienced complicated courses. Portal vein thrombosis and hepatic artery thrombosis seemed to be important factors for development of de novo fatty liver after transplantation.
authors: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Namazi Hospital, Shiraz, Iran.
authors: M
authors: M
authors: Zahmatkeshan
authors: B
authors: B
authors: Geramizadeh
authors: A
authors: A
authors: Eshraghian
authors: S
authors: S
authors: Nikeghbalian
authors: A
authors: A
authors: Bahador
authors: H
authors: H
authors: Salahi
authors: S A
authors: SA
authors: Malek-Hosseini
mesh_terms: D001656:Biliary Atresia / Q000150:complications / Q000628:therapy; D001706:Biopsy; D015992:Body Mass Index; D002648:Child; D005234:Fatty Liver / Q000150:complications / Q000175:diagnosis; D005260:Female; D006499:Hepatic Artery / Q000473:pathology; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D017093:Liver Failure / Q000150:complications / Q000628:therapy; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D011169:Portal Vein / Q000473:pathology; D012307:Risk Factors; D013927:Thrombosis; D018608:Ultrasonography, Doppler / Q000379:methods; D014652:Vascular Diseases / Q000150:complications