title: Neuropsychiatric symptoms of progressive supranuclear palsy in a dementia clinic.
abstract: BACKGROUND
  Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by supranuclear gaze palsy, postural instability, akinesia and other parkinsonism. Recently, the relationship between PSP and frontotemporal dementia (FTD) has been recognized, which includes clinical, pathological, biochemical and genetic features. However, there have been few studies that directly compared neuropsychiatric symptoms between PSP and FTD. The aim of the present study was to investigate comprehensive psychiatric and behavioural symptoms in PSP and compared them with those in FTD.
  
  
  METHODS
  Patients with PSP (n = 10) and FTD (n = 13) were selected on the basis of inclusion/exclusion criteria from a consecutive series in the dementia clinic of Kumamoto University Hospital. We assessed their comprehensive neuropsychiatric features by using the Neuropsychiatric Inventory (NPI), the Stereotypy Rating Inventory (SRI) and a specific antisocial behaviour checklist.
  
  
  RESULTS
  There were no significant differences in the total NPI and NPI subscale scores between the two groups. Both groups showed quite a similar pattern in the features of neuropsychiatric symptoms: apathy showed the highest score, followed by aberrant motor behaviour and disinhibition. The PSP group was significantly lower in the total SRI and eating and cooking behaviour scores than those in the FTD group. The prevalence of antisocial behaviours in PSP (50%) was equal to those in the FTD group (46%).
  
  
  CONCLUSIONS
  In a dementia clinic, the neuropsychiatric profile in patients with PSP closely resembled those in the FTD group. The present results suggest that PSP should be considered as not only a movement disorder, but also a disorder with a wide range of neuropsychiatric symptoms.
authors: Department of Psychiatry and Neuropathobiology, Kumamoto University Graduate School of Medical Science, Japan. yatababychan@yahoo.co.jp
authors: Yusuke
authors: Y
authors: Yatabe
authors: Mamoru
authors: M
authors: Hashimoto
authors: Keiichirou
authors: K
authors: Kaneda
authors: Kazuki
authors: K
authors: Honda
authors: Yusuke
authors: Y
authors: Ogawa
authors: Seiji
authors: S
authors: Yuuki
authors: Shiho
authors: S
authors: Matsuzaki
authors: Atsuko
authors: A
authors: Tuyuguchi
authors: Hiroko
authors: H
authors: Kashiwagi
authors: Manabu
authors: M
authors: Ikeda
mesh_terms: D000368:Aged; D001526:Behavioral Symptoms; D005260:Female; D057180:Frontotemporal Dementia / Q000175:diagnosis / Q000523:psychology*; D006801:Humans; D007564:Japan; D008297:Male; D009483:Neuropsychological Tests; D012725:Sexual Behavior; D012920:Social Behavior Disorders; D013239:Stereotyped Behavior; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000523:psychology*