title: Possible anti-metastatic effect of iloprost in a patient with systemic sclerosis with lung cancer: a case study.
abstract: Systemic sclerosis (SSc) is a chronic disease of unknown etiology which affects the vascular system and connective tissue. A wide series of studies showed an increased prevalence of cancer in patients with SSc than the normal population. Prostacyclin (PGI2) is an endogenously produced element that is basically synthesized by arachiodonic acid through prostacyclin synthesis in vascular system endothelial cells. Iloprost is a stable analogue of PGI2 which is used in the treatment of pulmonary arterial hypertension (PAH). In a limited number of animal models, the anti-metastatic activity of PGI2 is observed. Herein, we report iloprost treatment of a 60-year-old-woman with SSc, who lately developed PAH as a complication of her disease and lung adenocarcinoma as a co-incidence simultaneously. These two mortal complications were both treated successfully with inhaled iloprost until her death due to gastrointestinal complications of SSc.
authors: School of Medicine, Department of Rheumatologyn, Sahinbey Medical Center, Gaziantep University, TR-27310, Gaziantep, Turkey. drpehlivan@hotmail.com
authors: Yavuz
authors: Y
authors: Pehlivan
authors: Ibrahim Halil
authors: IH
authors: Turkbeyler
authors: Ozan
authors: O
authors: Balakan
authors: Alper
authors: A
authors: Sevinc
authors: Mustafa
authors: M
authors: Yilmaz
authors: Kemal
authors: K
authors: Bakir
authors: Ahmet Mesut
authors: AM
authors: Onat
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000077192:Adenocarcinoma of Lung; D000280:Administration, Inhalation; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D018450:Disease Progression; D065627:Familial Primary Pulmonary Hypertension; D017809:Fatal Outcome; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016285:Iloprost / Q000008:administration & dosage / Q000627:therapeutic use*; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D012595:Scleroderma, Systemic / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D014665:Vasodilator Agents; D016285:Iloprost