title: Functionalized carbon nanomaterials as nanocarriers for loading and delivery of a poorly water-soluble anticancer drug: a comparative study.
abstract: Carbon nanomaterials such as multiwalled carbon nanotubes (MWCNTs) and graphene oxide (GO) have been functionalized by highly hydrophilic and biocompatible poly(vinyl alcohol) (PVA) for loading and delivery of an anticancer drug, camptothecin (CPT). For the first time, CPT was loaded onto MWCNT-PVA and GO-PVA through π-π interactions and its capability to kill human breast and skin cancer cells was investigated.
authors: School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
authors: Nanda Gopal
authors: NG
authors: Sahoo
authors: Hongqian
authors: H
authors: Bao
authors: Yongzheng
authors: Y
authors: Pan
authors: Mintu
authors: M
authors: Pal
authors: Mitali
authors: M
authors: Kakran
authors: Henry Kuo Feng
authors: HK
authors: Cheng
authors: Lin
authors: L
authors: Li
authors: Lay Poh
authors: LP
authors: Tan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002166:Camptothecin / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006108:Graphite / Q000737:chemistry; D006801:Humans; D037742:Nanotubes, Carbon / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D014867:Water
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D037742:Nanotubes, Carbon; D012996:Solutions; D014867:Water; D006108:Graphite; D011142:Polyvinyl Alcohol; D002166:Camptothecin