title: Paraneoplastic muscle disease.
abstract: In paraneoplastic muscle disease, the malignancy may remotely affect neuromuscular transmission or incite muscle inflammation or necrosis. In several of these diseases, an autoimmune basis for the muscle disease has been established and has become a defining feature. These paraneoplastic muscle diseases may be the first manifestation of a malignancy, and their diagnosis thus demands a vigilant search for an underlying tumor. This article is focused on inflammatory and necrotizing myopathies and disorders of neuromuscular transmission that may arise in the setting of malignancy and are considered paraneoplastic phenomena.
authors: Division of Rheumatology, Johns Hopkins University School of Medicine, Good Samaritan Hospital, 5200 Eastern Avenue, Mason F. Lord Building Center Tower, Suite 4100, Room 413, Baltimore MD 21224, USA. alanbaer@jhmi.edu
authors: Alan N
authors: AN
authors: Baer
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology; D009135:Muscular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D009382:Neoplasms, Unknown Primary / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D020511:Neuromuscular Junction Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D010257:Paraneoplastic Syndromes