title: The relation of non-invasively and invasively assessed aortic pulsatile indices to the presence and severity of coronary artery disease.
abstract: OBJECTIVE
  The aim of the study was to assess the relationship between non-invasively (NIA) and invasively assessed (IA) aortic pulsatile indices and the presence and severity of coronary artery disease (CAD).
  
  
  METHODS
  The study group consisted of 58 patients who were admitted to our institute for elective coronary angiography (CAG). We measured the aortic systolic, diastolic and mean blood pressure (BP) using non-invasive and invasive techniques. We assessed the pulsatile indices of the aortic pressure waveform (APW) including pulse pressure (PP), fractional PP (FPP, the ratio of PP to mean BP) and pulsatility index (PI, the ratio of PP to diastolic BP). The severity of CAD was assessed by Gensini score.
  
  
  RESULTS
  IA aortic PP, FPP and PI were significantly higher in patients with CAD than without CAD, but NIA indices did not show significant differences between two groups. After multivariate stepwise adjustment, the odds ratio (OR) and confidence interval (CI) of having significant CAD was: PP per 10 mmHg, OR = 2.51 (95% CI 1.12-5.63); FPP per 0.1, OR = 3.30 (95% CI 1.25-8.72); and PI per 0.1, OR = 1.88 (95% CI 1.09-3.23). In linear regression analysis, IA aortic systolic BP (SBP), PP, FPP and PI were significantly correlated with Gensini score, but NIA indices were not correlated. The NIA aortic PP was lower than IA aortic PP (mean difference: 6.1 ± 15.8 mmHg).
  
  
  CONCLUSIONS
  IA aortic PP, FPP and PI were related to the presence and severity of CAD, but NIA assessed indices of APW were not related. NIA aortic PP underestimated IA aortic PP.
authors: Division of Cardiology, Department of Internal Medicine, Sanggye-Paik Hospital, Inje University College of Medicine, Seoul, Korea.
authors: Sung Woo
authors: SW
authors: Cho
authors: Byung Ok
authors: BO
authors: Kim
authors: Jeong Hoon
authors: JH
authors: Kim
authors: Young Sup
authors: YS
authors: Byun
authors: Choong Won
authors: CW
authors: Goh
authors: Kun Joo
authors: KJ
authors: Rhee
authors: Hee Kyung
authors: HK
authors: Kim
mesh_terms: D000368:Aged; D001011:Aorta / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D016017:Odds Ratio; D011673:Pulsatile Flow / Q000502:physiology*; D012307:Risk Factors; D012720:Severity of Illness Index