title: Characteristics of newly-formed cementum following Emdogain application.
abstract: Periodontal regenerative techniques have been proposed; however, the outcomes remain debatable. The present investigation assessed the regenerated cementum following enamel matrix derivative application in dehiscence-type defects. Buccal osseous dehiscences were surgically created on the maxillary cuspid, and the second and fourth premolars in five female beagle dogs. The treatment group (n = 15 sites) received the enamel matrix derived application, whereas the control groups (n = 15) did not. The dogs were sacrificed 4 months following treatment and the specimens were histologically and histometrically examined. The newly formed cementum was uneven in thickness and mineralization, overlapped the old cementum and exhibited functional orientation, cementocyte lacunae and collagen fibril bundles. Most of the histological specimens showed the presence of a gap between the newly formed cementum and the underlying dentin. Control sites did not exhibit any cementum formation. The present study concluded that newly formed cementum is of cellular type and exhibits multiple characteristics.
authors: Eng. A. B. Bagshan Growth Factors and Bone Regeneration Research Chair King Saud University, Riyadh, Saudi Arabia. alhezaim@usc.edu
authors: Khalid
authors: K
authors: Al-Hezaimi
authors: Mansour
authors: M
authors: Al-Askar
authors: Abdulaziz
authors: A
authors: Al-Rasheed
mesh_terms: D000818:Animals; D025021:Cementogenesis / Q000187:drug effects*; D003739:Dental Cementum / Q000166:cytology / Q000187:drug effects* / Q000601:surgery*; D003746:Dental Enamel Proteins / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D011897:Random Allocation; D012038:Regeneration / Q000187:drug effects*; D013529:Surgical Wound Dehiscence
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins