title: [Simplification to lopinavir/ritonavir monotherapy in HIV-infected children].
abstract: Lopinavir/ritonavir monotherapy as a simplification strategy has the potential to minimize antiretroviral treatment toxicity without losing efficacy in selected cases, according to studies in adults, but little is known in paediatric patients. We report 5 children on this regimen for a median time of 112 weeks. One child with suboptimal adherence required intensification therapy to re-suppress viral load. Randomised controlled trials are needed to evaluate the efficacy of this strategy in children in order to make appropriate recommendations.
authors: Servicio de Pediatría, Hospital del Mar, Barcelona, España. AMur@parcdesalutmar.cat
authors: A
authors: A
authors: Mur-Sierra
authors: N
authors: N
authors: López-Segura
authors: M A
authors: MA
authors: López-Vílchez
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000008:administration & dosage*; D006801:Humans; D061466:Lopinavir / Q000008:administration & dosage*; D008297:Male; D012189:Retrospective Studies; D019438:Ritonavir / Q000008:administration & dosage*
chemical_list: D017320:HIV Protease Inhibitors; D061466:Lopinavir; D019438:Ritonavir