title: Telomere G-overhang length measurement method 2: G-tail telomere HPA.
abstract: Both telomere length and telomere G-tail length are altered in human diseases such as cancer and -age-related disease. While most methods for the measurement of G-tail and telomere length require electrophoresis, centrifugation, radioisotope labeling, and autoradiography, G-tail telomere HPA provides a convenient and useful tool for the examination of G-tail length with a high-throughput platform using genomic DNA or cell lysate. G-tail telomere HPA may be applicable for clinical diagnostics as well as drug target screening.
authors: Department of Cellular and Molecular Biology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. toshi@hiroshima-u.ac.jp
authors: Hidetoshi
authors: H
authors: Tahara
mesh_terms: D004247:DNA / Q000235:genetics; D006147:Guanine / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods; D009693:Nucleic Acid Hybridization / Q000379:methods*; D013194:Staining and Labeling; D016615:Telomere / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
chemical_list: D006147:Guanine; D004247:DNA