title: Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin: a double-blind, randomized-controlled trial.
abstract: BACKGROUND
  All-trans-retinoic acid (RA) and all-trans-retinol (ROL) are not widely used as anti-wrinkle agents due to their irritancy and photo-stability, respectively. Therefore, the safety and photo-stability in the development of RA or ROL derivatives have been an important issue.
  
  
  OBJECTIVE
  To identify the efficacy of retinyl retinoate as an anti-aging agent of cosmetics in treating females over 30 years old with periorbital wrinkles.
  
  
  METHODS
  The clinical study was a prospective, double-blind, randomized, and controlled study with a total of 11 Korean women. At every 4 weeks, the effectiveness was assessed with a global photodamage score, photographs, and image analysis using replicas and visiometers. The dermal distance and intensity was also evaluated using Dermascan C.
  
  
  RESULTS
  A statistically significant improvement in facial wrinkles (P<0.05) in eleven volunteers was observed in a clinical trial. The successive application of 0.06% retinyl retinoate cream for 3 months showed decreased depth and area of wrinkles in comparison with 0.075% retinol cream. The visual wrinkle improvement and the maximum roughness improvement rate (R2) for retinyl retinoate cream were 22% higher than that of retinol cream after 12 weeks. A statistically significant increase was observed after 8 and 4 weeks for dermal distance and dermal intensity, respectively (P<0.05).
  
  
  CONCLUSIONS
  Retinyl retinoate had characteristic features of new anti-aging agents, and effectively improved facial wrinkle conditions.
authors: Department of Biotechnology, Yonsei University, Seoul, Korea.
authors: H
authors: H
authors: Kim
authors: J
authors: J
authors: Koh
authors: J
authors: J
authors: Baek
authors: Y
authors: Y
authors: Seo
authors: B
authors: B
authors: Kim
authors: J
authors: J
authors: Kim
authors: J
authors: J
authors: Lee
authors: H
authors: H
authors: Ryoo
authors: H
authors: H
authors: Jung
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003358:Cosmetics / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D012176:Retinoids / Q000008:administration & dosage*; D000084562:Retinyl Esters; D012867:Skin / Q000166:cytology* / Q000187:drug effects* / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects*; D016896:Treatment Outcome
chemical_list: D003358:Cosmetics; D012176:Retinoids; D000084562:Retinyl Esters; C529924:retinyl retinoate