title: Tumor accumulation of ε-poly-lysines-based polyamines conjugated with boron clusters.
abstract: Boron Neutron Capture Therapy (BNCT) is one of the potent cancer radiotherapies using nuclear reaction between (10)B atoms and the neutron. Whether BNCT will succeed or not depends on tumor selective delivery of (10)B compounds. ε-Poly-L-lysine is a naturally occurring polyamine characterized by the peptide linkages between the carboxyl and ε-amino groups of L-lysine. Because of high safety ε-PLL is applied practically as a food additive due to its strong antimicrobial activity. In this study, we focus on a development of a novel polymeric delivery system for BNCT using biodegradable ε-PLL conjugated with (10)B-containing clusters (BSH). This polymeric boron carrier will be expected to deliver safely and efficiently into tumor tissues based on Enhanced Permeability and Retention (EPR) effect.
authors: Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University, Sumiyoshi-ku, Osaka, Japan.
authors: Masayuki
authors: M
authors: Umano
authors: Kazuhiro
authors: K
authors: Uechi
authors: Takatoshi
authors: T
authors: Uriuda
authors: Sayuri
authors: S
authors: Murayama
authors: Hideki
authors: H
authors: Azuma
authors: Atsuko
authors: A
authors: Shinohara
authors: Young
authors: Y
authors: Liu
authors: Koji
authors: K
authors: Ono
authors: Mitsunori
authors: M
authors: Kirihata
authors: Hironobu
authors: H
authors: Yanagie
authors: Takeshi
authors: T
authors: Nagasaki
mesh_terms: D001895:Boron / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D011073:Polyamines / Q000378:metabolism* / Q000493:pharmacokinetics; D011107:Polylysine / Q000378:metabolism* / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D011073:Polyamines; D011107:Polylysine; D001895:Boron