title: Twenty-five years of peripheral blood stem cell transplantation.
abstract: Peripheral blood stem cell transplantation (PBSCT) is the most common transplantation procedure performed in medicine. Its clinical introduction in 1986 replaced BM as a stem-cell source to approximately 100% in the autologous and to approximately 75% in the allogeneic transplantation setting. This historical overview provides a brief insight into the discovery of circulating hematopoietic stem cells in the early 1960s, the development of apheresis technology, the discovery of hematopoietic growth factors and small molecule CXCR4 antagonist for stem- cell mobilization, and in vivo experimental transplantation studies that eventually led to clinical PBSCT. Also mentioned are the controversies surrounding the engraftment potential of circulating stem cells before acceptance as a clinical modality. Clinical trials comparing the outcome of PBSCT with BM transplantation, registry data analyses, and the role of the National Marrow Donor Program (NMDP) in promoting unrelated blood stem-cell donation are addressed.
authors: Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. mkorblin@mdanderson.org
authors: Martin
authors: M
authors: Körbling
authors: Emil J
authors: EJ
authors: Freireich
mesh_terms: D000818:Animals; D001781:Blood Component Removal / Q000379:methods; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D006801:Humans; D008954:Models, Biological; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods* / Q000639:trends*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D013997:Time Factors; D017211:Treatment Failure
chemical_list: D016298:Hematopoietic Cell Growth Factors