title: Dietary fiber is associated with circulating concentrations of C-reactive protein in breast cancer survivors: the HEAL study.
abstract: Inflammation is a suspected risk factor for breast cancer and its subsequent prognosis. The extent to which dietary and lifestyle factors might influence inflammation is important to examine. Specifically, dietary fiber may reduce systemic inflammation, but this relationship has not been examined among breast cancer survivors. We examined associations between dietary fiber and serum concentrations of C-reactive protein (CRP) and serum amyloid A (SAA), among 698 female breast cancer survivors from the Health, Eating, Activity, and Lifestyle (HEAL) Study. Data are from interviews and clinical visits conducted 24-months post-study enrollment. Multivariate-adjusted linear regression estimated associations of total, soluble, and insoluble fiber with serum concentrations of CRP and SAA. Logistic regression estimated the odds of elevated CRP (defined as >3.0 mg/l) across tertiles of dietary fiber intake. Mean total dietary fiber intake was 13.9 ± 6.4 g/day. Mean CRP and SAA were 3.32 ± 3.66 and 7.73 ± 10.23 mg/l, respectively. We observed a multivariate-adjusted inverse association between total dietary fiber intake and CRP concentrations (β, -0.029; 95% CI, -0.049, -0.008). Results for insoluble fiber were similar (β, -0.039; 95% CI, -0.064, -0.013). Among survivors who consumed >15.5 g/day of insoluble dietary fiber, a 49% reduction in the likelihood of having elevated CRP concentrations (OR, 0.51; 95% CI, 0.27, 0.95) was observed compared to those who consumed <5.4 g/day (P = 0.053). Our results suggest that diets high in fiber may benefit breast cancer survivors via reductions in systemic inflammation; elevated inflammation may be prognostic for reduced survival.
authors: Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M3-B232, Seattle, WA, 98109-1024, USA. avillase@fhcrc.org
authors: Adriana
authors: A
authors: Villaseñor
authors: Anita
authors: A
authors: Ambs
authors: Rachel
authors: R
authors: Ballard-Barbash
authors: Kathy B
authors: KB
authors: Baumgartner
authors: Anne
authors: A
authors: McTiernan
authors: Cornelia M
authors: CM
authors: Ulrich
authors: Marian L
authors: ML
authors: Neuhouser
mesh_terms: D001741:Black or African American; D015415:Biomarkers / Q000097:blood; D001943:Breast Neoplasms / Q000208:ethnology / Q000401:mortality / Q000628:therapy*; D002097:C-Reactive Protein / Q000032:analysis*; D004043:Dietary Fiber / Q000008:administration & dosage*; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007249:Inflammation / Q000208:ethnology / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000097:blood*; D016014:Linear Models; D016015:Logistic Models; D016017:Odds Ratio; D000685:Serum Amyloid A Protein / Q000032:analysis; D017741:Survivors / Q000706:statistics & numerical data; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D044465:White People
chemical_list: D015415:Biomarkers; D004043:Dietary Fiber; D018836:Inflammation Mediators; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein