title: Supramolecular assembly and antitumor activity of multiwalled carbon nanotube-camptothecin complexes.
abstract: The novel supramolecular complexes were prepared with a water-insoluble anticancer drug camptothecin (CPT) loading onto functionalized multiwalled carbon nanotubes via pi-stacking, in order to improve their solubility and antitumor activity. The multiwalled carbon nanotubes were firstly coated with the tri-block copolymer (Pluronic P123) to render high aqueous solubility. The copolymer-coated multiwalled carbon nanotubes can effectively form non-covalent supramolecular complexes with camptothecin. The supramolecular assembly of the complexes (f-MWNTs-CPT) were systematically characterized by transmission electron microscopy (TEM), UV-vis spectrophotometry (UV), fluorescence spectrophotometry, atomic force microscopy (AFM) and electrochemical impedance spectroscopy (EIS). Furthermore, in vitro cytotoxicity studies of f-MWNTs-CPT supramolecular complexes using the MTT assay exhibit enhanced antitumor activity, suggesting that the functionalized multiwalled carbon nanotubes can facilitate intracellular delivery of anticancer drug and improve drug activity.
authors: Department of Chemistry, Life and Environmental Science College, Shanghai Normal University, Shanghai 200234, China.
authors: Zhong
authors: Z
authors: Tian
authors: Min
authors: M
authors: Yin
authors: Hongmei
authors: H
authors: Ma
authors: Longzhang
authors: L
authors: Zhu
authors: Hebei
authors: H
authors: Shen
authors: Nengqin
authors: N
authors: Jia
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D002166:Camptothecin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D055664:Electrochemical Techniques; D006367:HeLa Cells; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry / Q000648:ultrastructure; D018625:Microscopy, Atomic Force; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D050997:Nanomedicine; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011060:Poloxalene; D012995:Solubility; D013499:Surface Properties
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D046911:Macromolecular Substances; D037742:Nanotubes, Carbon; C464484:pluronic block copolymer P123; D011060:Poloxalene; D002166:Camptothecin