title: Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro.
abstract: Many plants are used in Ayurveda for the treatment of tuberculosis. Our aim was to examine if these plants possess any specific molecule that inhibits Mycobacterium tuberculosis. One of them, Kaempferia galanga, yielded an anti-TB molecule, ethyl p-methoxycinnamate (EPMC). By resazurin microtitre assay (REMA), EPMC was shown to inhibit M. tuberculosis H37Ra, H37Rv, drug susceptible and multidrug resistant (MDR) clinical isolates (MIC 0.242-0.485mM). No cross resistance was observed to any standard anti-TB drugs in the MDR strains. The compound did not inhibit any prototype bacteria tested. EPMC seems to be a potential anti-TB lead molecule.
authors: Department of Molecular Microbiology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.
authors: Divya
authors: D
authors: Lakshmanan
authors: Jim
authors: J
authors: Werngren
authors: Leny
authors: L
authors: Jose
authors: K P
authors: KP
authors: Suja
authors: Mangalam S
authors: MS
authors: Nair
authors: R Luxmi
authors: RL
authors: Varma
authors: Sathish
authors: S
authors: Mundayoor
authors: Sven
authors: S
authors: Hoffner
authors: R Ajay
authors: RA
authors: Kumar
mesh_terms: D000995:Antitubercular Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002934:Cinnamates / Q000302:isolation & purification / Q000494:pharmacology*; D004351:Drug Resistance / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D027343:Rhizome; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D000995:Antitubercular Agents; D002934:Cinnamates; D010936:Plant Extracts; C531364:ethyl 4-methoxycinnamate