title: New antitrypanosomal tetranotriterpenoids from Azadirachta indica.
abstract: Organic extracts of the leaves of Azadirachta indica A. Juss. yielded ten antitrypanosomal terpenoids. Three of these (1-3), are novel and are derivatives of nimbolide and nimbin. They were extracted from chloroform fraction of methanol extract. These compounds were found to exhibit strong antitrypanosomal activities against Trypanosoma brucei rhodesiense with MIC values ranging of 6.9, 15.6 and 7.8 µg/ml respectively and were more active than Cymerlarsan (a standard drug), which had an MIC value of 187.5 µg/ml when tested against T. b. rhodesiense. The structures were elucidated by spectroscopic methods including; NMR, MS, UV and IR.
authors: Department of Chemistry, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya. githuamercy@yahoo.co.uk
authors: Mercy
authors: M
authors: Githua
authors: Ahmed
authors: A
authors: Hassanali
authors: Joseph
authors: J
authors: Keriko
authors: Grace
authors: G
authors: Murilla
authors: Mary
authors: M
authors: Ndungu
authors: Gathu
authors: G
authors: Nyagah
mesh_terms: D001152:Arsenicals / Q000627:therapeutic use; D031601:Azadirachta / Q000737:chemistry*; D002845:Chromatography; D006801:Humans; D036701:Limonins / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects*; D014353:Trypanosomiasis, African / Q000188:drug therapy*
chemical_list: D001152:Arsenicals; D036701:Limonins; D010936:Plant Extracts; D014344:Trypanocidal Agents; C042198:nimbolide; C062789:melaminylthioarsenate; C008621:nimbin