title: Evidence-based prevention (EBP): A review of cytochrome P450 expression in the bronchial epithelium and new approach to lung cancer prevention.
abstract: The number of fatalities in Japan attributable to lung cancer exceeded 50000 in 2001. It is socially desirable that various markers, which can be utilized for the prevention of lung cancer, be established. We believe that smoking or exposure to carcinogens in air induces mutations in bronchial and alveolar epithelia, leading to the development of lung cancer. It would be useful to have markers of individual differences in susceptibility to chemical carcinogen-induced lung cancer 1) to identify genetic polymorphisms of enzymes metabolizing chemical carcinogens and 2) to investigate the expression of enzymes metabolizing chemical carcinogens. In this paper, we review CYP expression in the bronchial epithelium. CYP1, CYP2 and CYP3 are expressed in the bronchial epithelium. We also show the relationship between the genetic polymorphisms of cytochrome P450 (CYP) and a person's susceptibility to chemical carcinogen-induced lung cancer. We demonstrate the relationship between cigarette consumption and the CYP expression profile in the bronchial epithelium. To maintain and promote public health, we must apply evidence, such as CYP polymorphisms and CYP profiles to disease prevention and also to aggressively advance evidence-based prevention (EBP) of lung cancer.
authors: Department of Environmental Health, University of Occupational and Environmental Health, 807-8555, Kitakyushu, Japan, oyama@med.uoeh-u.ac.jp.
authors: Tsunehiro
authors: T
authors: Oyama
authors: Toyohi
authors: T
authors: Isse
authors: Tomoe
authors: T
authors: Murakami
authors: Rie
authors: R
authors: Suzuki-Narai
authors: Masanori
authors: M
authors: Ogawa
authors: Tetsunosuke
authors: T
authors: Yamaguchi
authors: Tsuyoshi
authors: T
authors: Kinaga
authors: Yasunori
authors: Y
authors: Yashima
authors: Shinichi
authors: S
authors: Ozaki
authors: Yong-Dae
authors: YD
authors: Kim
authors: Heon
authors: H
authors: Kim
authors: Toshihiro
authors: T
authors: Kawamoto