title: A case of acute aortic thrombosis after cisplatin-based chemotherapy.
abstract: Cisplatin-based therapy is associated with various toxicities, including renal failure and neuropathy. However, acute arterial thrombosis is also a possible toxic effect of cisplatin, one that has been documented in a few cases worldwide. Here we present a rare case of ascending aortic thrombosis occurring 9 days after cisplatin-based chemotherapy in a 74-year-old male who was diagnosed with malignant pleural effusion suggestive of non-small cell lung cancer. The patient did not have any predisposing factor for the occurrence of an aortic thrombus before cisplatin-based chemotherapy. Thus, we suggest that the hypercoagulable state occurred secondary to cisplatin-based chemotherapy and was additive to the malignancy itself, causing aortic thrombosis. The patient was treated successfully with low-molecular-weight heparin and warfarin.
authors: Department of Internal Medicine, Dongguk University Ilsan Hospital, 814 Sicksadong Ilsandong-gu, Goyang 410-773, South Korea.
authors: Suk Jae
authors: SJ
authors: Hahn
authors: Jin Young
authors: JY
authors: Oh
authors: Jeung Sook
authors: JS
authors: Kim
authors: Do Yeun
authors: DY
authors: Kim
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D001011:Aorta / Q000473:pathology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D016066:Pleural Effusion, Malignant / Q000188:drug therapy; D013927:Thrombosis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D006493:Heparin; D002945:Cisplatin