title: The application of next-generation sequencing technologies to drug discovery and development.
abstract: Next-generation sequencing (NGS) technologies represent a paradigm shift in sequencing capability. The technology has already been extensively applied to biological research, resulting in significant and remarkable insights into the molecular biology of cells. In this review, we focus on current and potential applications of the technology as applied to the drug discovery and development process. Early applications have focused on the oncology and infectious disease therapeutic areas, with emerging use in biopharmaceutical development and vaccine production in evidence. Although this technology has great potential, significant challenges remain, particularly around the storage, transfer and analysis of the substantial data sets generated.
authors: Computational Biology, Drug Discovery, GlaxoSmithKline Research and Development, Gunnels Wood Road, Stevenage, UK. Peter.M.Woollard@gsk.com
authors: Peter M
authors: PM
authors: Woollard
authors: Nalini A L
authors: NA
authors: Mehta
authors: Jessica J
authors: JJ
authors: Vamathevan
authors: Stephanie
authors: S
authors: Van Horn
authors: Bhushan K
authors: BK
authors: Bonde
authors: David J
authors: DJ
authors: Dow
mesh_terms: D000818:Animals; D001702:Biopharmaceutics / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods*; D011110:Polymorphism, Genetic; D057285:Precision Medicine / Q000379:methods; D017422:Sequence Analysis, DNA / Q000379:methods*; D017423:Sequence Analysis, RNA / Q000379:methods; D012984:Software