title: Effect of alcohol drinking and cigarette smoking on neutrophil functions in adults.
abstract: In recent years, the effects of smoking and excessive alcohol consumption on immune function have been studied, due to a high prevalence of infection or cancer in heavy drinkers, and the combination of smoking and drinking was considered to be a carcinogenic risk. However, the effect of smoking and drinking on systemic immune function has yet to be clearly understood. In this study, we investigated neutrophil functions (reactive oxygen species (ROS) productive activity, phagocytic ability and serum opsonic activity) and their relationship with alcohol consumption or amount of smoking. In total there were 731 male and female adult subjects who participated in the Iwaki Health Promotion Project in 2005. Multiple regression analysis showed a trend of increased ROS production in male subjects and a statistically significant decrease was observed in phagocytic activity caused by smoking in female subjects. In other words, oxidative stress caused by smoking in male subjects may be involved in ROS production from neutrophils. Decreased phagocytic activity of neutrophils caused by smoking suggests that host defense functions were impaired in female subjects. A relationship between neutrophil functions and the amount of alcohol consumption was not observed.
authors: Department of Social Medicine, Hirosaki University Graduate School of Medicine, Zaifu-cho 5, Hirosaki, 036-8562 Aomori, Japan.
authors: Junya
authors: J
authors: Sato
authors: Ippei
authors: I
authors: Takahashi
authors: Takashi
authors: T
authors: Umeda
authors: Masashi
authors: M
authors: Matsuzaka
authors: Kazuma
authors: K
authors: Danjyo
authors: Ryosuke
authors: R
authors: Tsuya
authors: Kazuyuki
authors: K
authors: Kida
authors: Hideki
authors: H
authors: Takami
authors: Shigeyuki
authors: S
authors: Nakaji
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D012907:Smoking / Q000276:immunology*; D014026:Nicotiana