title: Gentian violet exhibits activity against biofilms formed by oral Candida isolates obtained from HIV-infected patients.
abstract: The effect of gentian violet against Candida albicans and non-Candida albicans biofilms formed on polymethylmethacrylate strips was evaluated using a dry weight assay and confocal laser scanning microscopy. The ability of gentian violet to inhibit Candida albicans germination was also assessed. Gentian violet activity against Candida biofilms was demonstrated by a reduction in dry weight, disruption of biofilm architecture, and reduced biofilm thickness. Additionally, gentian violet inhibited Candida germination in a concentration-dependent manner.
authors: Center for Medical Mycology, Department of Dermatology, Division of Infectious Diseases and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
authors: Rana S
authors: RS
authors: Traboulsi
authors: Pranab K
authors: PK
authors: Mukherjee
authors: Jyotsna
authors: J
authors: Chandra
authors: Robert A
authors: RA
authors: Salata
authors: Richard
authors: R
authors: Jurevic
authors: Mahmoud A
authors: MA
authors: Ghannoum
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D002180:Candidiasis, Oral / Q000382:microbiology*; D004305:Dose-Response Relationship, Drug; D005840:Gentian Violet / Q000494:pharmacology*; D015658:HIV Infections / Q000382:microbiology*; D006801:Humans; D018613:Microscopy, Confocal
chemical_list: D000891:Anti-Infective Agents, Local; D005840:Gentian Violet