title: Arabidopsis ORGAN SIZE RELATED1 regulates organ growth and final organ size in orchestration with ARGOS and ARL.
abstract: • The growth of a plant organ to its characteristic size is regulated by an elaborate developmental program involving both internal and external signals. Here, we identify a novel Arabidopsis gene, ORGAN SIZE RELATED1 (OSR1), that is involved in regulation of organ growth and overall organ size. • A combination of genetic, cytological and molecular approaches was used to characterize the expression profile, subcellular localization and roles of OSR1 during organ growth. • Ectopic expression of OSR1 in Arabidopsis resulted in enlarged organs, as a consequence of increases in both cell number and cell size. OSR1 shares a conserved OSR domain with ARGOS and ARGOS-LIKE (ARL), which is sufficient for their functions in promoting organ growth. OSR1 is a plant hormone-responsive gene and appears to act redundantly with ARGOS and ARL during organ growth. The OSR proteins are localized to the endoplasmic reticulum. • Our results suggest that three co-evolved members of the OSR family may act coordinately to orchestrate growth signals and cell proliferation and expansion, thereby affecting organ growth and final organ size.
authors: Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.|Graduate School of Chinese Academy of Sciences, Beijing, China.
authors: Guanping
authors: G
authors: Feng
authors: Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.
authors: Zhixiang
authors: Z
authors: Qin
authors: Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.|Graduate School of Chinese Academy of Sciences, Beijing, China.
authors: Jingzhou
authors: J
authors: Yan
authors: Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.|Graduate School of Chinese Academy of Sciences, Beijing, China.
authors: Xiaoran
authors: X
authors: Zhang
authors: Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.|National Center for Plant Gene Research, Beijing, China.
authors: Yuxin
authors: Y
authors: Hu
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D004721:Endoplasmic Reticulum / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009154:Mutation; D038081:Organogenesis; D010641:Phenotype; D010802:Phylogeny; D010937:Plant Growth Regulators / Q000494:pharmacology; D018515:Plant Leaves / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D030821:Plants, Genetically Modified / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000235:genetics; D018749:RNA, Plant / Q000235:genetics; D036226:Seedlings / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: C099055:AINTEGUMENTA protein, Arabidopsis; C479806:ARGOS protein, Arabidopsis; C513745:ARL protein, Arabidopsis; D029681:Arabidopsis Proteins; D008565:Membrane Proteins; C581917:OSR1 protein, Arabidopsis; D010937:Plant Growth Regulators; D012333:RNA, Messenger; D018749:RNA, Plant; D014157:Transcription Factors