title: Delayed G-CSF stimulation after PBSCT does not seem to modify the biological parameters of bone marrow recovery.
abstract: There are currently no recommendations indicating when stimulation should begin after autologous peripheral blood stem cell transplantation (PBSCT). We compared the outcome following between two treatment groups, in which daily granulocyte colony stimulating factor (G-CSF) administration began on either the fifth or the eighth day after PBSCT in lymphoma and myeloma patients. We studied eight clinical parameters: number of G-CSF injections, number of days of hospitalization, of red blood cell or platelet transfusions; days when body temperature exceeds 38°C; days of parenteral nutrition; weight loss and hospitalization costs. We studied also four biological parameters: number of CD34+ cells, days with leucocytes less than 1 × 10(9) /L, days with hemoglobin less than 90 g/L or with less than 50 × 10(9) /L of platelets. There were no statistical significant differences between the study arms. It seems that delayed stimulation by G-CSF after PBSCT is safety and does not seem to modify bone marrow recovery timing.
authors: Department of Clinical Hematology, Institute of Oncology and Hematology, Hopital Morvan, CHRU Brest, France. jcianotto@hotmail.com
authors: Jean-Christophe
authors: JC
authors: Ianotto
authors: Adrian
authors: A
authors: Tempescul
authors: Pascal
authors: P
authors: Delepine
authors: Gaelle
authors: G
authors: Guillerm
authors: Elisabeth
authors: E
authors: Hardy
authors: Jean-Richard
authors: JR
authors: Eveillard
authors: Christian
authors: C
authors: Berthou
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001853:Bone Marrow / Q000187:drug effects*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000627:therapeutic use; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy / Q000628:therapy*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D011994:Recombinant Proteins; D013997:Time Factors; D019172:Transplantation Conditioning; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor