title: Enantioselective synthesis induced by chiral crystal composed of DL-serine in conjunction with asymmetric autocatalysis.
abstract: Asymmetric autocatalysis initiated by chiral crystals containing racemic DL-serine was achieved. P- and M-crystals of DL-serine acted as the source of chirality of asymmetric autocatalysis to afford highly enantioenriched (>99.5% ee) (S)- and (R)-pyrimidylalkanols after the amplification of ee. This is the first example of the usage of the crystal, which contains the same number of D- and L-enantiomers as an origin of chirality in enantioselective synthesis.
authors: Department of Applied Chemistry and Research Institute for Science and Technology, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. tkawa@rs.kagu.tus.ac.jp
authors: Tsuneomi
authors: T
authors: Kawasaki
authors: Taisuke
authors: T
authors: Sasagawa
authors: Kazuya
authors: K
authors: Shiozawa
authors: Mizuki
authors: M
authors: Uchida
authors: Kenta
authors: K
authors: Suzuki
authors: Kenso
authors: K
authors: Soai
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis; D002384:Catalysis; D015394:Molecular Structure; D011743:Pyrimidines / Q000737:chemistry; D012694:Serine / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000473:Alkanes; D011743:Pyrimidines; D012694:Serine; C030986:pyrimidine