title: What are a patient's current chances of finding a matched unrelated donor? Twenty years' central search experience in a small country.
abstract: Between 1988 and 2007, international searches for matched unrelated donors (MUDs) were performed for 1586 Austrian patients. Between 2004 and 2007, a MUD was identified for 76.7% of the patients. Between 1996 and 2003, a donor was identified for 71.3% of the patients, and between 1988 and 1995, only for 53.4% of the patients. Search times of successful searches decreased from 7.7 months in the first period to 1.7 months in the period from 2004 to 2007. However, transplants were not performed in all cases in which a donor was found: only in 61.6% of the patients between 2004 and 2007, in 53.4% between 1996 and 2003 and in 29.6% between 1988 and 1995. Multivariate analysis determined that having a common HLA type was the most important variable impacting on finding a MUD for a patient. Factors that most strongly influence a patient's access to transplant were the patient's European origin and a short time between diagnosis and start of donor search. The strongest factor for both finding a donor and being transplanted was a search being performed during more recent years: patients' chances increased from year to year.
authors: Department of Blood Group Serology, Medical University of Vienna, Vienna, Austria. agathe.rosenmayr@austrianregistry.at
authors: A
authors: A
authors: Rosenmayr
authors: M
authors: M
authors: Pointner-Prager
authors: A
authors: A
authors: Mitterschiffthaler
authors: L
authors: L
authors: Bozic
authors: B
authors: B
authors: Pelzmann
authors: H
authors: H
authors: Tüchler
authors: I
authors: I
authors: Fae
authors: G F
authors: GF
authors: Fischer
authors: H T
authors: HT
authors: Greinix
authors: Ch
authors: Ch
authors: Peters
authors: P
authors: P
authors: Kalhs
authors: O
authors: O
authors: Krieger
authors: W
authors: W
authors: Linkesch
authors: D
authors: D
authors: Nachbaur
authors: Ch
authors: Ch
authors: Urban
authors: U
authors: U
authors: Posch
authors: G
authors: G
authors: Lanzer
authors: Ch
authors: Ch
authors: Gabriel
authors: H
authors: H
authors: Schennach
authors: W R
authors: WR
authors: Mayr
mesh_terms: D000328:Adult; D001317:Austria; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D019520:Living Donors / Q000706:statistics & numerical data / Q000600:supply & distribution*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D009927:Tissue and Organ Procurement / Q000379:methods*; D061349:Unrelated Donors / Q000706:statistics & numerical data / Q000600:supply & distribution*
chemical_list: D006680:HLA Antigens