title: Interactions of topiramate with polyethylene glycol 8000 in solid state with formation of new polymorph.
abstract: Topiramate [2,3:4,5-bis-O-(1-methylethylidene) β-D-fructo-pyranose sulfamate] was found to form a new polymorphic form in the presence of polyethylene glycol 8000 (PEG). Comparative study of the solid state interactions of PEG and structural topiramate analogue lacking sulfamate group (Diacetone D-fructose) indicated that the sulfamate moiety was essential for the formation of the new polymorph. The drug-polymer interactions were investigated using differential s canning calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and hot stage microscopy. The new polymorphic form was characterized using variable temperature powder X-ray diffraction (VTPXRD) and solid state Nuclear Magnetic Resonance (ssNMR). The new polymorph was found to form only in the presence of PEG at specific weight ratios.
authors: University of the Pacific, Thomas J Long School of Pharmacy & Health Sciences, 3601 Pacific Avenue, Stockton, CA 95211, United States.
authors: Noymi
authors: N
authors: Yam
authors: Xiaoling
authors: X
authors: Li
authors: Bhaskara R
authors: BR
authors: Jasti
mesh_terms: D000927:Anticonvulsants / Q000032:analysis / Q000737:chemistry*; D003460:Crystallization; D004339:Drug Compounding; D004347:Drug Interactions; D005079:Excipients / Q000032:analysis / Q000737:chemistry*; D005632:Fructose / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011092:Polyethylene Glycols / Q000032:analysis / Q000737:chemistry*; D011108:Polymers / Q000032:analysis / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D000077236:Topiramate; D014961:X-Ray Diffraction
chemical_list: D000927:Anticonvulsants; D005079:Excipients; D011108:Polymers; D000077236:Topiramate; D005632:Fructose; D011092:Polyethylene Glycols