title: Cocrystallization via planetary milling: enhancing throughput of solid-state screening methods.
abstract: The application of a novel modified planetary mill, with the capacity to process 48 samples in parallel, to the rapid screening of pharmaceutical cocrystals via grinding is demonstrated for carbamazepine/saccharin, caffeine/oxalic acid, and caffeine/maleic acid cocrystals. Milling is performed directly in standard glass vials therefore no vessel decontamination is needed or sample loss occurs. Furthermore, successive sample processing can be employed without the need for additional material, making the system suitable for screening compounds of limited availability. Use of the system in an automated screening workflow of dispensing, milling, and analysis with high-throughput is also discussed.
authors: Automaxion SARL, L'Auvrairie, 50250 Varenguebec, France. stephen.bysouth@automaxionltd.com
authors: Stephen R
authors: SR
authors: Bysouth
authors: Joanna A
authors: JA
authors: Bis
authors: David
authors: D
authors: Igo
mesh_terms: D003460:Crystallization / Q000379:methods*; D004339:Drug Compounding / Q000295:instrumentation* / Q000379:methods; D004864:Equipment and Supplies; D005079:Excipients / Q000032:analysis / Q000737:chemistry*; D057166:High-Throughput Screening Assays; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry*; D011208:Powders / Q000737:chemistry
chemical_list: D005079:Excipients; D004364:Pharmaceutical Preparations; D011208:Powders