title: Putting the brakes on the unfolded protein response.
abstract: The unfolded protein response is an ancient cellular pathway for rapidly responding to endoplasmic reticulum stress. Two studies in this issue (Rubio et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201007077 and Chawla et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201008071) provide insight into how the unfolded protein response is tamped down to restore normal endoplasmic reticulum function. Although both papers implicate the Ire1 kinase domain as the key effector of the off-switch mechanism, alternate models for how this is achieved are proposed.
authors: Program in Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5. sicheri@lunenfeld.ca
authors: Frank
authors: F
authors: Sicheri
authors: Robert H
authors: RH
authors: Silverman
mesh_terms: D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D017510:Protein Folding; D056811:Unfolded Protein Response; D019892:eIF-2 Kinase / Q000378:metabolism
chemical_list: D019892:eIF-2 Kinase