title: Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo.
abstract: Recently, the coffee constituents 5-O-caffeoylquinic acid (CGA) and N-methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant-response element (ARE) detoxifying pathway under cell-culture condition. To study the impact of CGA and NMP on the Nrf2-activating properties of a complex coffee beverage, two different model coffees were generated by variation of the roasting conditions: a low-roast coffee rich in CGA and a heavy-roast low in CGA but containing high levels of NMP. Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo.
authors: University of Vienna, Department of Food Chemistry and Toxicology, Vienna, Austria.
authors: Ute
authors: U
authors: Boettler
authors: Nadine
authors: N
authors: Volz
authors: Gudrun
authors: G
authors: Pahlke
authors: Nicole
authors: N
authors: Teller
authors: Christine
authors: C
authors: Kotyczka
authors: Veronika
authors: V
authors: Somoza
authors: Herbert
authors: H
authors: Stiebitz
authors: Gerhard
authors: G
authors: Bytof
authors: Ingo
authors: I
authors: Lantz
authors: Roman
authors: R
authors: Lang
authors: Thomas
authors: T
authors: Hofmann
authors: Doris
authors: D
authors: Marko
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D018890:Chemoprevention; D002726:Chlorogenic Acid / Q000494:pharmacology*; D003069:Coffee / Q000737:chemistry*; D004790:Enzyme Induction / Q000187:drug effects; D005721:Glutamate-Cysteine Ligase / Q000096:biosynthesis; D019073:HT29 Cells; D051547:Heme Oxygenase-1 / Q000096:biosynthesis; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000502:physiology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D020218:Response Elements / Q000502:physiology*
chemical_list: D000975:Antioxidants; D003069:Coffee; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D011726:Pyridinium Compounds; D017382:Reactive Oxygen Species; D002726:Chlorogenic Acid; C014677:1-methylpyridinium; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1; D005721:Glutamate-Cysteine Ligase