title: Directly observing therapy: a new view of drug tolerance in tuberculosis.
abstract: Drug tolerance in bacteria is widely believed to be due to metabolic changes that accompany growth arrest. A study in this issue of Cell reveals a drug tolerance mechanism in replicating mycobacteria that is induced by residence in macrophages and depends on drug efflux.
authors: Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, 522 First Avenue, Smilow 901, New York, NY 10016, USA.
authors: Jennifer A
authors: JA
authors: Philips
authors: Joel D
authors: JD
authors: Ernst