title: [Immunological and bacteriological monitoring of patients with pneumonia and influenza A/H1N1 infection].
abstract: OBJECTIVE
  To study features of immune status and causative agents of severe pneumonia in patients with influenza A/H1N1.
  
  
  METHODS
  Fifty-seven isolates from 43 patients with pneumonia, which complicated pandemic influenza A/ H1N1 and treated in Chita city clinical hospital No.1 as well as 32 immunograms were retrospectively studied. Comparison of immunologic and epidemiologic status of patients with influenza A/ H1N1 complicated by pneumonia was performed. Data on dynamics of epidemic process and outcomes are presented.
  
  
  RESULTS
  It was established that severe course of influenza A/H1N1 complicated by pneumonia characterized by relative lymphopenia, 2-fold decrease of CD3+ cells, 2.9-fold decrease of CD4+ cells, and 1.7-fold decrease of CD8+ lymphocytes. Degree of changes in parameters of cellular immunity corresponded to severity of pneumonia. Bacteriologic tests showed that there was contamination of respiratory tract of patients with influenza A/H1N1 by opportunistic microflora, predominantly by Streptococcus mitis.
  
  
  CONCLUSIONS
  In patients with severe form of influenza A/H1N1, which complicated by development of pneumonia, depression of T-cell immunity with contamination of respiratory tract by opportunistic microflora and prolonged course of pathologic process was observed.
authors: K G
authors: KG
authors: Shapovalov
authors: T E
authors: TE
authors: Belokrinitskaia
authors: Zh S
authors: ZhS
authors: Burdinskaia
authors: A V
authors: AV
authors: Maliarchikov
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count / Q000379:methods; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007251:Influenza, Human / Q000097:blood / Q000150:complications / Q000276:immunology*; D008231:Lymphopenia / Q000097:blood / Q000150:complications / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D018410:Pneumonia, Bacterial / Q000150:complications / Q000276:immunology*; D012800:Siberia; D013290:Streptococcal Infections / Q000097:blood / Q000150:complications / Q000276:immunology*; D034361:Streptococcus mitis / Q000276:immunology*