title: Mono-, di-, or triazidated cyclodextrin-based polyrotaxanes for facile and efficient functionalization via click chemistry.
abstract: As a feasible way for controlling the density of ligands in polyrotaxanes, azidated polyrotaxanes comprising PEG (MW= 3,000 and 20,000 g · mol(-1)) and mono-, di-, or triazidated α-cyclodextrins are prepared in a water/DMSO solution in a one-pot synthesis. The azidated polyrotaxanes are then allowed to conjugate with propargyl-modified mannose as a ligand via click chemistry. As proven by FTIR spectroscopy and (1)H NMR-spectroscopy, mannose molecules are efficiently introduced into all of the azide moieties of the polyrotaxanes. The results verify the achievement of ligand-density-controlled polyrotaxanes. The functionalized polyrotaxanes can be utilized for a variety of biological applications.
authors: School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923-1292, Japan.
authors: Hoon
authors: H
authors: Hyun
authors: Nobuhiko
authors: N
authors: Yui
mesh_terms: D057930:Click Chemistry / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D008970:Molecular Weight; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D043862:Rotaxanes / Q000737:chemistry*
chemical_list: D003505:Cyclodextrins; D008024:Ligands; D011108:Polymers; D043862:Rotaxanes