title: Non-traumatic myelopathy at the Chris Hani Baragwanath Hospital, South Africa--the influence of HIV.
abstract: BACKGROUND
  Non-traumatic myelopathy from developing regions has been described widely. In these regions infections, mainly tuberculosis, followed by acute transverse myelitis and neoplasms, dominate. These are also regions of high HIV prevalence. In developed regions, the most prominent reported spinal cord disease in HIV/AIDS is vacuolar myelopathy (VM). Other myelopathy causes in HIV/AIDS include opportunistic infections, neoplasms, vascular lesions and metabolic disease. In developing regions, opportunistic infections are more commonly encountered with VM occurring less frequently.
  
  
  OBJECTIVE
  To determine the influence of HIV on the myelopathy spectrum in an HIV endemic region.
  
  
  METHODS
  Prospective case series.
  
  
  METHODS
  Hundred unselected consecutive in-patients admitted with myelopathy were studied. Myelopathy aetiologies were established by collating information obtained from magnetic resonance imaging (MRI) scans, CSF and blood studies, CXR findings, non-neurological illness and response to treatment. Data were analysed in terms of two cohorts, HIV positive and HIV negative.
  
  
  RESULTS
  Approximately 50% of the patients presenting and admitted to our hospital with non-traumatic myelopathy are HIV positive. The HIV positive myelopathy patients were younger (20-40 years) and had infectious aetiologies. Tuberculosis was the most frequently identified cause of myelopathy. The majority of HIV-positive patients had advanced HIV infection. Anti-retroviral treatment did not influence myelopathy aetiologies. The HIV-negative patients were older and had neoplasms, followed by degenerative spondylosis as the main myelopathy causes.
  
  
  CONCLUSIONS
  HIV influences the non-traumatic myelopathy spectrum in regions with high HIV prevalence. Empiric treatment of HIV-myelopathy patients with anti-tuberculous medications where resources are severely limited has merit.
authors: Department of Neurosciences, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York road, Partktown, Johannesburg, Gauteng 2193, South Africa. gmodicns@mweb.co.za
authors: G
authors: G
authors: Modi
authors: J
authors: J
authors: Ranchhod
authors: K
authors: K
authors: Hari
authors: A
authors: A
authors: Mochan
authors: M
authors: M
authors: Modi
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010264:Paraplegia; D011446:Prospective Studies; D013019:South Africa / Q000453:epidemiology; D013118:Spinal Cord Diseases / Q000453:epidemiology* / Q000209:etiology / Q000821:virology*; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents