title: The bone marrow niche in Waldenström's macroglobulinemia.
abstract: The widespread involvement of the bone marrow with tumor cells indicates that there is continuous cell trafficking of WM cells in and out of the bone marrow leading to cell dissemination in the bone marrow and in the lymph nodes in many patients with WM. The interaction of the WM cells with the bone marrow is critical for the regulation of cell proliferation, cell cycle, drug resistance as well as cell dissemination and trafficking. Advances in understanding the interaction of the tumor clone with the BM microenvironment have led to the development of therapeutic agents that not only target the tumor clone but also regulate the bone marrow microenvironment. Here, we review the role of the cellular and liquid bone marrow compartments in the regulation of cell proliferation and dissemination in WM.
authors: Dana-Farber Cancer Institute, Boston, MA 02115, USA. irene_ghobrial@dfci.harvard.edu
authors: Irene M
authors: IM
authors: Ghobrial
authors: Yong
authors: Y
authors: Zhang
authors: Yang
authors: Y
authors: Liu
authors: Hai
authors: H
authors: Ngo
authors: Feda
authors: F
authors: Azab
authors: Antonio
authors: A
authors: Sacco
authors: Abdelkareem
authors: A
authors: Azab
authors: Patricia
authors: P
authors: Maiso
authors: Brittany
authors: B
authors: Morgan
authors: Phong
authors: P
authors: Quang
authors: Ghayas
authors: G
authors: Issa
authors: Aldo
authors: A
authors: Roccaro
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D048708:Cell Growth Processes / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008258:Waldenstrom Macroglobulinemia / Q000473:pathology*