title: AGEs secreted by bacteria are involved in the inflammatory response.
abstract: Advanced Glycated End Products (AGEs) are formed by non-enzymatic protein glycation and are implicated in several physiological aspects including cell aging and diseases. Recent data indicate that bacteria--although short lived--produce, metabolize and accumulate AGEs. Here we show that Escherichia coli cells secret AGEs by the energy-dependent efflux pump systems. Moreover, we show that in the presence of these AGEs there is an upshift of pro-inflammatory cytokins by mammalian cells. Thus, we propose that secretion of AGEs by bacteria is a novel avenue of bacterial-induced inflammation which is potentially important in the pathophysiology of bacterial infections. Moreover, the sensing of AGEs by the host cells may constitute a warning system for the presence of bacteria.
authors: Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
authors: Ifat
authors: I
authors: Cohen-Or
authors: Chen
authors: C
authors: Katz
authors: Eliora Z
authors: EZ
authors: Ron
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007700:Kinetics
chemical_list: D017127:Glycation End Products, Advanced