title: A molecular phylogeny of living primates.
abstract: Comparative genomic analyses of primates offer considerable potential to define and understand the processes that mold, shape, and transform the human genome. However, primate taxonomy is both complex and controversial, with marginal unifying consensus of the evolutionary hierarchy of extant primate species. Here we provide new genomic sequence (~8 Mb) from 186 primates representing 61 (~90%) of the described genera, and we include outgroup species from Dermoptera, Scandentia, and Lagomorpha. The resultant phylogeny is exceptionally robust and illuminates events in primate evolution from ancient to recent, clarifying numerous taxonomic controversies and providing new data on human evolution. Ongoing speciation, reticulate evolution, ancient relic lineages, unequal rates of evolution, and disparate distributions of insertions/deletions among the reconstructed primate lineages are uncovered. Our resolution of the primate phylogeny provides an essential evolutionary framework with far-reaching applications including: human selection and adaptation, global emergence of zoonotic diseases, mammalian comparative genomics, primate taxonomy, and conservation of endangered species.
authors: Laboratory of Genomic Diversity, National Cancer Institute-Frederick, Frederick, Maryland, USA.
authors: Polina
authors: P
authors: Perelman
authors: Warren E
authors: WE
authors: Johnson
authors: Christian
authors: C
authors: Roos
authors: Hector N
authors: HN
authors: Seuánez
authors: Julie E
authors: JE
authors: Horvath
authors: Miguel A M
authors: MA
authors: Moreira
authors: Bailey
authors: B
authors: Kessing
authors: Joan
authors: J
authors: Pontius
authors: Melody
authors: M
authors: Roelke
authors: Yves
authors: Y
authors: Rumpler
authors: Maria Paula C
authors: MP
authors: Schneider
authors: Artur
authors: A
authors: Silva
authors: Stephen J
authors: SJ
authors: O'Brien
authors: Jill
authors: J
authors: Pecon-Slattery
mesh_terms: D000818:Animals; D019295:Computational Biology; D005260:Female; D014644:Genetic Variation; D016678:Genome / Q000235:genetics; D008297:Male; D010802:Phylogeny; D011323:Primates / Q000145:classification* / Q000235:genetics*