title: [Indolent firm reddish papules. Cutaneous Rosai-Dorfman disease].
abstract: Sinus histiocytosis with massive lymphadenopathy (SHML) is generally characterized by severe illness and massive cervical lymphadenopathy. Sinus histiocytosis limited to the skin is now recognized as a rare distinct entity called cutaneous Rosai-Dorfman disease (CRD). We report CRD in a 57-year-old male patient presenting with disseminated firm red-brown papules. Histology revealed a dermal infiltrate with CD1a-, CD68+, S100+ multinuclear giant cells. Some of these histiocytes showed hemophagocytosis (emperipolesis). We achieved a good therapeutic result with topical clobetasol propionate.
authors: Centre Hospitalier Régional d'Orléans, Service de Dermatologie, Hôpital Porte Madeleine, Orléans cedex 1, France. guido.bens@chr-orleans.fr
authors: G
authors: G
authors: Bens
authors: R
authors: R
authors: Kerdraon
authors: J-J
authors: JJ
authors: De Kyvon
authors: E
authors: E
authors: Estève
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents