title: Association of plasma vitamin B6 with risk of colorectal adenoma in a multiethnic case-control study.
abstract: Circulating level of vitamin B6 has been inversely associated with colorectal cancer (CRC) risk but, unlike for folate, few studies have examined the relationship of vitamin B6 to colorectal adenoma, the precursor lesion to most CRCs. We measured plasma levels of folate, vitamin B6, and vitamin B12 in 241 patients with pathologically confirmed first occurrence of colorectal adenoma and 280 controls among Caucasians, Japanese Americans, and Native Hawaiians undergoing flexible sigmoidoscopy screening in Hawaii. High plasma level of vitamin B6 was independently inversely associated with risk of colorectal adenoma [multivariate odds ratios (95% confidence intervals): 1.0, 0.71 (0.45-1.13) and 0.44 (0.26-0.74) from the lowest to the highest tertile, respectively, p (trend) = 0.002]. Plasma folate was not associated with adenoma after adjustment for plasma vitamin B6 (p (trend) > 0.3). No association was observed with plasma vitamin B12. No significant interaction was detected between the three B vitamins and alcohol intake, multivitamin use or MTHFR C677T. The results provide evidence for an inverse association of plasma vitamin B6 levels with risk of colorectal adenoma. This study expands previous findings and suggests that vitamin B6 may be protective against the early stages of colorectal carcinogenesis.
authors: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA. Loic@crch.hawaii.edu
authors: Loïc
authors: L
authors: Le Marchand
authors: Hansong
authors: H
authors: Wang
authors: Jacob
authors: J
authors: Selhub
authors: Thomas M
authors: TM
authors: Vogt
authors: Lance
authors: L
authors: Yokochi
authors: Robert
authors: R
authors: Decker
mesh_terms: D000236:Adenoma / Q000097:blood / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D000368:Aged; D001213:Asian / Q000706:statistics & numerical data; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D006254:Hawaii / Q000453:epidemiology / Q000208:ethnology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D025101:Vitamin B 6 / Q000097:blood*; D044465:White People / Q000706:statistics & numerical data
chemical_list: D025101:Vitamin B 6