title: A patient undergoing chronic dialysis whose renal anemia was successfully corrected by treatment with cinacalcet.
abstract: A 62-year-old female dialysis patient with chronic glomerulonephritis had been receiving hemodialysis therapy for 32 years. In 1985 she underwent a parathyroidectomy for secondary hyperparathyroidism (HPT); however, her parathyroid hormone (PTH) levels gradually increased. Her serum calcium level ranged from 9.0 to 10.0 mg/dL, which caused difficulties in performing vitamin D injection therapy. No parathyroid glands were seen by echography or scintigraphy. On 31 March 2008 her intact PTH (iPTH) level was 895 pg/mL so treatment with cinacalcet 25 mg/day was started. After 3 months her iPTH level decreased to 269 pg/mL and her hemoglobin level increased from 9.3 to 12.9 g/dL. In some cases of severe HPT, anemia improves after parathyroidectomy; however, in this case, cinacalcet improved not only secondary HPT but also anemia.
authors: Division of Nephrology, Department Internal Medicine, Kawasaki Medical School Kawasaki Hospital, 2-1-80 Nakasange, Kitaku, Okayama, Okayama 700-8505, Japan. y.oshiro@kawasaki-hp.jp
authors: Yoshiyuki
authors: Y
authors: Oshiro
authors: Hisataka
authors: H
authors: Tanaka
authors: Niro
authors: N
authors: Okimoto
mesh_terms: D000740:Anemia / Q000188:drug therapy / Q000209:etiology*; D057966:Calcimimetic Agents / Q000627:therapeutic use*; D000069449:Cinacalcet; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood; D006962:Hyperparathyroidism, Secondary / Q000209:etiology*; D007674:Kidney Diseases / Q000188:drug therapy / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000150:complications*; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use*; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D006435:Renal Dialysis / Q000009:adverse effects
chemical_list: D057966:Calcimimetic Agents; D009281:Naphthalenes; D010281:Parathyroid Hormone; D000069449:Cinacalcet