title: Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents.
abstract: Two novel nano-cage compounds, 8 and 9, were prepared by self-assembly of the ruthenium complexes 4 and 5, and the tripodal donor 1. The cytotoxicity of 8 was found to be considerably stronger than that of cisplatin. The complex 8 inhibited tumor cell proliferation by interfering into regulatory pathways of the cell cycle via apoptosis.
authors: Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea.
authors: Vaishali
authors: V
authors: Vajpayee
authors: Yoon Jung
authors: YJ
authors: Yang
authors: Se Chan
authors: SC
authors: Kang
authors: Hyunuk
authors: H
authors: Kim
authors: In Su
authors: IS
authors: Kim
authors: Ming
authors: M
authors: Wang
authors: Peter J
authors: PJ
authors: Stang
authors: Ki-Whan
authors: KW
authors: Chi
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D012428:Ruthenium; D002945:Cisplatin