title: Strain-tailored double-disk synergy test detects extended-spectrum oxacillinases in Pseudomonas aeruginosa.
abstract: The prevalence of class D extended-spectrum oxacillinases (ES-OXAs) in ceftazidime-resistant strains of Pseudomonas aeruginosa is often underestimated by double-disk synergy tests (DDST) using clavulanate. A DDST with a customized distance between a disk of ceftazidime or cefepime and inhibitors (clavulanate and imipenem) detected 14 out of 15 different ES-OXAs.
authors: Service de Bactériologie, Centre National de Référence de la Résistance aux Antibiotiques, Laboratoire Associé Pseudomonas aeruginosa, Centre Hospitalier Universitaire, Besançon, France. dhocquet@univ-fcomte.fr
authors: Didier
authors: D
authors: Hocquet
authors: Barbara
authors: B
authors: Dehecq
authors: Xavier
authors: X
authors: Bertrand
authors: Patrick
authors: P
authors: Plésiat
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology*; D012680:Sensitivity and Specificity; D001618:beta-Lactamases / Q000378:metabolism*; D047090:beta-Lactams / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases; C108449:oxacillinase