title: Impaired left-ventricular cardiac function in male GPR30-deficient mice.
abstract: G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventricles from male mutant mice were enlarged. There were no malformations in the valves or outflow tract of the heart. Both the contractility and relaxation capacity of the left ventricle were reduced, leading to increased left‑ventricular end-diastolic pressure in GPR30-deficient mice. In conclusion, our data support a role for GPR30 in the gender-specific aspects of heart failure.
authors: Cardiology Research, Bayer Schering Pharma AG, 42096 Wuppertal, Germany. martina.delbeck@bayerhealthcare.com
authors: Martina
authors: M
authors: Delbeck
authors: Stefan
authors: S
authors: Golz
authors: Richardus
authors: R
authors: Vonk
authors: Wiebke
authors: W
authors: Janssen
authors: Tim
authors: T
authors: Hucho
authors: Jörg
authors: J
authors: Isensee
authors: Stefan
authors: S
authors: Schäfer
authors: Christiane
authors: C
authors: Otto
mesh_terms: D000818:Animals; D005260:Female; D017353:Gene Deletion; D006333:Heart Failure / Q000235:genetics; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012737:Sex Factors; D016277:Ventricular Function, Left
chemical_list: C532507:GPER1 protein, mouse; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled