title: γ Chain transducing element: a shared pathway between endocrine and immune system.
abstract: Several molecules, involved in the intracellular communication network, have been identified as the cause of primary immunodeficiencies. In most cases, these molecules are exclusively expressed in hematopoietic cells, being involved in cell development and/or functionality of terminal differentiated cells of immune system. In the case of γc, the abundance of the protein suggests a potential pleiotropic effect of the molecule. Immune and endocrine systems participate to an integrated network of soluble mediators that communicate and coordinate responsive cells to achieve effector functions in an appropriate fashion. It has been demonstrated a novel dependence of GH signaling on the common cytokines receptor γc in certain cell types, supporting the hypothesis of an interplay between endocrine and immune system. The evidence that different receptors share a few molecules may certainly lead to a better knowledge on the mechanism of coordination and integration of several pathways implicated in the control of cell growth and proliferation under physiological or pathogenic conditions. This review focuses on the γc as a common transducing element shared between several cytokines and growth hormone receptors, indicating a further functional link between endocrine and immune system.
authors: Department of Pediatrics, Unit of Immunology, Federico II University, via S. Pansini 5-80131, Naples, Italy.
authors: Ilaria
authors: I
authors: Vigliano
authors: Anna
authors: A
authors: Fusco
authors: Loredana
authors: L
authors: Palamaro
authors: Giuseppina
authors: G
authors: Aloj
authors: Emilia
authors: E
authors: Cirillo
authors: Maria Carolina
authors: MC
authors: Salerno
authors: Claudio
authors: C
authors: Pignata
mesh_terms: D000818:Animals; D017124:Conserved Sequence; D004703:Endocrine System / Q000276:immunology*; D006801:Humans; D007107:Immune System; D007142:Immunoglobulin gamma-Chains / Q000235:genetics* / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D007142:Immunoglobulin gamma-Chains