title: Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene.
abstract: Schizophrenia is a complex disorder with a high heritability. Relatives with schizophrenia have an increased risk not only for schizophrenia but also for schizophrenia spectrum disorders, such as schizotypal personality disorder. A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, has been implicated in susceptibility to schizophrenia by several genome-wide association studies, follow-up association studies and meta-analyses. This SNP has been shown to affect neuronal connectivities and cognitive abilities. We investigated an association between the ZNF804A genotype of rs1344706 and schizotypal personality traits using the Schizotypal Personality Questionnaire (SPQ) in 176 healthy subjects. We also looked for specific associations among ZNF804A polymorphisms and the three factors of schizotypy-cognitive/perceptual, interpersonal and disorganization-assessed by the SPQ. The total score for the SPQ in carriers of the risk T allele was significantly higher than that in individuals with the G/G genotype (p=0.042). For the three factors derived from the SPQ, carriers with the risk T allele showed a higher disorganization factor (p=0.011), but there were no differences in the cognitive/perceptual or interpersonal factors between genotype groups (p>0.30). These results suggest that the genetic variation in ZNF804A might increase susceptibility not only for schizophrenia but also for schizotypal personality traits in healthy subjects.
authors: Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Yuka
authors: Y
authors: Yasuda
authors: Ryota
authors: R
authors: Hashimoto
authors: Kazutaka
authors: K
authors: Ohi
authors: Motoyuki
authors: M
authors: Fukumoto
authors: Satomi
authors: S
authors: Umeda-Yano
authors: Hidenaga
authors: H
authors: Yamamori
authors: Tomo
authors: T
authors: Okochi
authors: Masao
authors: M
authors: Iwase
authors: Hiroaki
authors: H
authors: Kazui
authors: Nakao
authors: N
authors: Iwata
authors: Masatoshi
authors: M
authors: Takeda
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012569:Schizotypal Personality Disorder / Q000235:genetics*; D055815:Young Adult
chemical_list: D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human