title: Pd(II)-catalyzed ortho arylation of 6-arylpurines with aryl iodides via purine-directed C-H activation: a new strategy for modification of 6-arylpurine derivatives.
abstract: Purine is utilized as a new directing group for the Pd-catalyzed monoarylation of 6-arylpurines with simple aryl iodides via C-H bond activation in good yields, providing a complementary tool for the modification of 6-arylpurines (nucleosides). Most importantly, purine can be used as a building block for nucleoside derivatives, and the use of purine as a directing group helps avoid additional synthetic steps.
authors: College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang, 453007, China. guohm518@hotmail.com
authors: Hai-Ming
authors: HM
authors: Guo
authors: Li-Li
authors: LL
authors: Jiang
authors: Hong-Ying
authors: HY
authors: Niu
authors: Wei-Hao
authors: WH
authors: Rao
authors: Lei
authors: L
authors: Liang
authors: Run-Ze
authors: RZ
authors: Mao
authors: De-Yang
authors: DY
authors: Li
authors: Gui-Rong
authors: GR
authors: Qu
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011687:Purines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007454:Iodides; D011687:Purines; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; C030985:purine