title: The effects of desflurane and sevoflurane on the peri- and postoperative bleeding of adenotonsillectomy patients.
abstract: OBJECTIVE
  To compare the effects of, volatile anesthetics, desflurane and sevoflurane on intra-operative and postoperative bleeding in patients who underwent tonsillectomy and adenoidectomy.
  
  
  METHODS
  Totally 40 children (14 girl and 26 boys) aged between 2 and 16years were included in this prospective randomized double-blind clinical trial. The patients underwent conventional cold tonsillectomy and curettage adenoidectomy under general anesthesia. For the maintenance of anesthesia, the patients were randomized into two groups; desflurane group and sevoflurane group, each including 20 subjects. Desflurane concentration was set between 4% and 6% (0.7-0.9 MAC), whereas sevoflurane concentration was set between 2% and 2.5% (0.7-0.9 MAC). The amount of perioperative bleeding in milliliters was measured by using separate aspirator bags for each patient.
  
  
  RESULTS
  Desflurane caused significantly lower amount of perioperative bleeding compared to sevoflurane (p=0.03). No significant difference was observed between the two groups in terms of age, body mass index and operation duration, respectively (p=0.20, p=0.49, p=0.07).
  
  
  CONCLUSIONS
  Desflurane, which is one of the volatile anesthetics, leads to a lower amount of intraoperative bleeding than sevoflurane during tonsillectomy and adenoidectomy operations.
authors: Abant Izzet Baysal University, Faculty of Izzet Baysal Medicine, Department of Otolaryngology, Bolu, Turkey.
authors: Tayfun
authors: T
authors: Apuhan
authors: Yavuz Selim
authors: YS
authors: Yıldırım
authors: Fadlullah
authors: F
authors: Aksoy
authors: Özlem
authors: Ö
authors: Borçin
authors: Orhan
authors: O
authors: Özturan
mesh_terms: D000233:Adenoidectomy / Q000009:adverse effects*; D000293:Adolescent; D018685:Anesthetics, Inhalation; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D000077335:Desflurane; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008738:Methyl Ethers / Q000627:therapeutic use*; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D000077149:Sevoflurane; D014068:Tonsillectomy / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane