title: S-phase-coupled apoptosis in tumor suppression.
abstract: DNA replication is essential for accurate transmission of genomic information from parental to daughter cells. DNA replication is licensed once per cell division cycle. This process is highly regulated by both positive and negative regulators. Over-replication, under-replication, as well as DNA damage in a cell all induce the activation of checkpoint control pathways such as ATM/ATR, CHK kinases, and the tumor suppressor protein p53, which provide "damage controls" via either DNA repairs or apoptosis. This review focuses on accumulating evidence, with the emphasis on recently discovered Killin, that S-phase checkpoint control is crucial for a mammalian cell to make a life and death decision in order to safeguard genome integrity.
authors: Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. y.cho@vanderbilt.edu
authors: Yong-Jig
authors: YJ
authors: Cho
authors: Peng
authors: P
authors: Liang
mesh_terms: D017209:Apoptosis; D050704:E2F4 Transcription Factor / Q000378:metabolism; D006801:Humans; D016196:S Phase; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D050704:E2F4 Transcription Factor; C554482:KLLN protein, human; D025521:Tumor Suppressor Proteins