title: Prevalence of hantavirus infection in wild rodents from five provinces in Korea, 2007.
abstract: Hemorrhagic fever with renal syndrome (HFRS) is an infectious disease caused by hantaviruses of the family Bunyaviridae. Among them, Hantaan virus (HTNV) is most widely distributed in Korea. The striped field mouse, Apodemus agrarius, is the natural host of HTNV in rural Korea. We trapped 766 small mammals of three species (1 Eothenomys regulus, 13 Crocidura suaveolens, and 752 Apodemus agrarius) in five provinces in Korea from January to December 2007. We tested 542 rodent sera for HTNV antibodies by an indirect immunofluorescent assay (IFA), finding antibody prevalences of 4 to 29% among the five provinces. Peaks in monthly antibody prevalence occurred in spring and fall. Antibody prevalence during the second peak coincided increased HFRS incidence in autumn. We used multiplex reverse transcription polymerase chain reaction (RT-PCR) to detect the partial S segment of Hantaan, Seoul, and Puumala viruses in 766 lung samples of all captured animals and found HTNV RNA in 25 A. agrarius. Two isolates of HTNV were obtained from PCR-positive A. agrarius by cultivation in Vero E6 cells. This first systemic survey of monthly antibody prevalence in hantavirus hosts in wide regions in Korea could provide useful information for other researchers studying environmental and ecological factors affecting HFRS.
authors: Division of Arboviruses, Center for Immunology & Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, 194, Tongil-Lo, Eunpyung-Gu, Seoul, 122-701, Korea.
authors: Jungsang
authors: J
authors: Ryou
authors: Hee Il
authors: HI
authors: Lee
authors: Youn Jeong
authors: YJ
authors: Yoo
authors: Yoon Tae
authors: YT
authors: Noh
authors: Seok-Min
authors: SM
authors: Yun
authors: Su Yeon
authors: SY
authors: Kim
authors: E-Hyun
authors: EH
authors: Shin
authors: Myung Guk
authors: MG
authors: Han
authors: Young Ran
authors: YR
authors: Ju
mesh_terms: D000818:Animals; D000835:Animals, Wild / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D007723:Korea / Q000453:epidemiology; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D012376:Rodent Diseases / Q000453:epidemiology* / Q000821:virology; D012377:Rodentia; D012621:Seasons; D029263:Seoul virus / Q000276:immunology*; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral