title: Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea: the IVANHOE study.
abstract: The aim of the IVANHOE study was to determine the real-world impact of the rotavirus vaccine, controlling for epidemic-to-epidemic variation in disease burden. A population-based prospective cohort study was conducted in Brest City and 7 suburban districts (CUB area), North-western Brittany, France (210,000 inhabitants; 5500 births per year). The vaccination program started in May 2007 for a 2-year period for all infants born in the Brest birth zone through pediatricians, public outpatient clinics and general practitioners. To determine vaccine impact we monitored trends in hospitalizations for rotavirus-specific diarrhea using an active hospital-based surveillance system initiated 5 years before vaccine introduction. The number of hospitalizations for rotavirus-specific diarrhea during the 2008/2009 epidemic in infants less than 2 years of age whose parents lived within the CUB area was modelled as a function of (1) the number of hospitalizations in infants 2-5 years of age to control for epidemic-to-epidemic variation and (2) vaccine introduction. A total of 4684 infants received at least one dose. Of these, 2635 lived within the CUB area. Vaccine coverage for a complete schedule in the CUB area was 47.1%. Poisson modelling revealed a reduction by a factor of 2.04 (1.56-2.66) in the number of hospitalizations during the last epidemic season (2008/2009), the number of observed cases being equal to 30, against an expected number of 61. Relative risk reduction for hospitalizations for rotavirus diarrhea was 98% (95% CI: 83-100%). We observed a noticeable impact of vaccination on rotavirus diarrhea hospitalizations within 2 years of vaccine introduction integrating for the first time rotavirus epidemics variation. The trial is registered with ClinicalTrials.gov, number, NCT00740935.
authors: Pediatrics Department, Brest University Hospital, France.
authors: Arnaud
authors: A
authors: Gagneur
authors: Emmanuel
authors: E
authors: Nowak
authors: Thomas
authors: T
authors: Lemaitre
authors: Jean-Francois
authors: JF
authors: Segura
authors: Nadège
authors: N
authors: Delaperrière
authors: Lydie
authors: L
authors: Abalea
authors: Elise
authors: E
authors: Poulhazan
authors: Anne
authors: A
authors: Jossens
authors: Lucie
authors: L
authors: Auzanneau
authors: Adissa
authors: A
authors: Tran
authors: Christopher
authors: C
authors: Payan
authors: Nadine
authors: N
authors: Jay
authors: Loic
authors: L
authors: de Parscau
authors: Emmanuel
authors: E
authors: Oger
mesh_terms: D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D005602:France; D005759:Gastroenteritis / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D017589:Immunization Programs; D007223:Infant; D011446:Prospective Studies; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000008:administration & dosage*; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: D022243:Rotavirus Vaccines