title: Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.
abstract: Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure-activity relationships evaluated for activity at the H(4) receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds.
authors: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. smeduna@its.jnj.com
authors: Steven P
authors: SP
authors: Meduna
authors: Brad M
authors: BM
authors: Savall
authors: Hui
authors: H
authors: Cai
authors: James P
authors: JP
authors: Edwards
authors: Robin L
authors: RL
authors: Thurmond
authors: Patricia M
authors: PM
authors: McGovern
mesh_terms: D000588:Amines / Q000737:chemistry; D001667:Binding, Competitive; D001681:Biological Assay; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors*; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; C418607:HRH4 protein, human; D011725:Pyridines; D011743:Pyrimidines; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4