title: The role of virus-specific CD4+ T cells in the control of Epstein-Barr virus infection.
abstract: Epstein-Barr virus (EBV) establishes lifelong persistent infections in humans and has been implicated in the pathogenesis of several human malignancies. Protective immunity against EBV is mediated by T cells, as indicated by an increased incidence of EBV-associated malignancies in immunocompromised patients, and by the successful treatment of EBV-associated post-transplant lymphoproliferative disease (PTLD) in transplant recipients by the infusion of polyclonal EBV-specific T cell lines. To implement this treatment modality as a conventional therapeutic option, and to extend this protocol to other EBV-associated diseases, generic and more direct approaches for the generation of EBV-specific T cell lines enriched in disease-relevant specificities need to be developed. To this aim, we studied the poorly defined EBV-specific CD4+ T cell response during acute and chronic infection.
authors: Clinical Cooperation Group, Pediatric Tumor Immunology, Helmholtz-Zentrum München, Marchioninistrasse 25, Munich, Germany. mautner@helmholtz-muenchen.de
authors: Josef
authors: J
authors: Mautner
authors: Georg W
authors: GW
authors: Bornkamm
mesh_terms: D056704:Adaptive Immunity; D019264:Adoptive Transfer / Q000379:methods*; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000821:virology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation / Q000821:virology; D002460:Cell Line; D003001:Cloning, Molecular; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000276:immunology* / Q000628:therapy / Q000821:virology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology; D016679:Genome, Viral; D015698:Genomic Library; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D017710:Lymphocyte Transfusion; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000276:immunology* / Q000628:therapy / Q000821:virology; D051379:Mice; D011994:Recombinant Proteins / Q000276:immunology; D014771:Virion / Q000276:immunology
chemical_list: D019309:Epstein-Barr Virus Nuclear Antigens; D011994:Recombinant Proteins