title: Incident hyperglycaemia among older adults with or at-risk for HIV infection.
abstract: BACKGROUND
  HIV infection has been associated with development of prediabetes and diabetes. Optimum screening practices for these disorders in HIV-infected populations remain unclear.
  
  
  METHODS
  We screened 377 adults, with or at-risk for HIV infection, for incident hyperglycaemia (prediabetes or diabetes) using two oral glucose tolerance tests (OGTTs) a median of 18.6 months apart. We determined proportion of incident cases detected by fasting and 120-min plasma glucose levels. Independent predictors of incident hyperglycaemia were identified using logistic regression.
  
  
  RESULTS
  The baseline OGTT was consistent with diabetes in 7% of participants and with prediabetes in 31%. Among 352 normoglycaemic and prediabetic participants at baseline, 19 (5%) developed diabetes on follow-up. Among participants normoglycaemic at baseline, an additional 38 (16%) developed prediabetes. Overall 52% of incident hyperglycaemia cases were detected by fasting plasma glucose alone, 33% by a 120-min glucose level alone and 15% by both. Factors independently associated with incident hyperglycaemia included age ≥50 years and body mass index ≥30 kg/m(2). Neither HIV infection nor highly active antiretroviral therapy (HAART) use were associated with increased risk of diabetes.
  
  
  CONCLUSIONS
  Incident hyperglycaemia is common among older adults with or at-risk for HIV infection. HIV-infected individuals with classic diabetes risk factors should be screened for hyperglycaemia regardless of HAART use. OGTTs might be the preferred screening strategy in HIV-infected individuals at high risk for developing hyperglycaemia.
authors: Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Denver, USA.
authors: Sarit
authors: S
authors: Polsky
authors: Michelle
authors: M
authors: Floris-Moore
authors: Ellie E
authors: EE
authors: Schoenbaum
authors: Robert S
authors: RS
authors: Klein
authors: Julia H
authors: JH
authors: Arnsten
authors: Andrea A
authors: AA
authors: Howard
mesh_terms: D000328:Adult; D000368:Aged; D048909:Diabetes Complications / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005951:Glucose Tolerance Test; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors