title: [Regulation of Ca2+ influx in proliferating and differentiating myoblasts of mice with participation of L-type Ca2+ channels].
abstract: The basic mechanisms of regulation of Ca2+ influx in proliferating and differentiating myoblasts, in culture have been studied. The presence of L-type Ca2+ channels in proliferating myoblasts has been shown for the first time. The influx of Ca2+ through these channels was shown to be regulated by the adrenergic system. The influx of Ca2+ through L-type Ca2+ channels after the activation of the adrenergic system by the addition of adrenaline in comparison with the contribution of reticular stocks exhausted by ATP in calcium-free medium was estimated. It was shown that the Ca2+ influx in proliferating myoblasts is regulated by beta-2 adrenergic receptors whose action is mediated by adenylate cyclase through L-type calcium channels. In differentiating myoblasts, the Ca2+ influx on the activation of the adrenergic system was essentially lower than in proliferating cells. It was found that the maximum influx of Ca2+ may be reached by the exhaustion of reticular stocks.
authors: A M
authors: AM
authors: Krasnyĭ
authors: T G
authors: TG
authors: Sefikhanov
authors: N D
authors: ND
authors: Ozerniuk
mesh_terms: D000262:Adenylyl Cyclases / Q000502:physiology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000502:physiology*; D020013:Calcium Signaling; D002454:Cell Differentiation; D002460:Cell Line; D049109:Cell Proliferation; D004837:Epinephrine / Q000494:pharmacology; D051379:Mice; D032446:Myoblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology
chemical_list: D000318:Adrenergic beta-Agonists; D020746:Calcium Channels, L-Type; D018343:Receptors, Adrenergic, beta-2; D000262:Adenylyl Cyclases; D002118:Calcium; D004837:Epinephrine