title: [Influence of hormonal therapy on the level of prostate specific antigen in patients with advanced prostatic cancer].
abstract: BACKGROUND
  The aim of this study was to investigate the influence of androgen blockades on prostate specific antigen (PSA) values in patients with locally advanced and metastatic prostatic cancer.
  
  
  METHODS
  The research was conducted on 60 patients. The group of 45 patients with prostatic cancer was divided into 3 subgroups, based on the type of the applied treatment protocol (15 patients on monotherapy with luteinizing hormone-releasing hormone agonists, 15 patients on total androgen blockade and 15 patients on monotherapy with antiandrogen). The control group consisted of 15 patients with benign prostatic hyperplasia. For all patients, the values of testosterone, luteinizing hormone and prostate specific antigen were monitored before as well as after 3 and 6 months during the treatment protocol.
  
  
  RESULTS
  All types of the applied treatment protocols in the therapy of prostatic cancer decreased the values of prostate specific antigen significantly. The application of total androgen blockade and monotherapy with luteinizing hormone-releasing hormone agonists decreased the levels of prostate specific antigen significantly in comparison with monotherapy with antiandrogen.
  
  
  CONCLUSIONS
  Although prostate specific antigen is not a prostatic cancer specific parameter; the dynamics of its decrease during the therapy of androgen blockade represents a significant marker of the therapy effect.
authors: Klinika za urologiju, Klinicki centar Vojvodine, Novi Sad. saravoj@ptt.yu
authors: Sasa
authors: S
authors: Vojinov
authors: Goran
authors: G
authors: Marusić
authors: Ivan
authors: I
authors: Levakov
authors: Jelena
authors: J
authors: Popadić-Gaćesa
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy*
chemical_list: D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal; D017430:Prostate-Specific Antigen