title: Microangiopathic disorders in pregnancy.
abstract: Microangiopathic disorders present with thrombocytopenia, hemolytic anemia, and multiorgan damage. In pregnancy, these disorders present a challenge both diagnostically and therapeutically, with widely overlapping clinical scenarios and disparate treatments. Although rare, a clear understanding of these diseases is important because devastating maternal and fetal outcomes may ensue if there is misdiagnosis and improper treatment. Microangiopathic disorders presenting in pregnancy are thus best assessed and treated by both obstetric and hematology teams. As a better understanding of the pathophysiology underlying each of the disease processes is gained, new diagnostic testing and therapies will be available, which will lead to improved outcomes.
authors: Section of Hematology Oncology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520-8063, USA. salley.pels@yale.edu
authors: Salley G
authors: SG
authors: Pels
authors: Michael J
authors: MJ
authors: Paidas
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology / Q000628:therapy; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000628:therapy