title: Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.
abstract: Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.
authors: Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
authors: Kathryn G
authors: KG
authors: Ewens
authors: Michelle R
authors: MR
authors: Jones
authors: Wendy
authors: W
authors: Ankener
authors: Douglas R
authors: DR
authors: Stewart
authors: Margrit
authors: M
authors: Urbanek
authors: Andrea
authors: A
authors: Dunaif
authors: Richard S
authors: RS
authors: Legro
authors: Angela
authors: A
authors: Chua
authors: Ricardo
authors: R
authors: Azziz
authors: Richard S
authors: RS
authors: Spielman
authors: Mark O
authors: MO
authors: Goodarzi
authors: Jerome F
authors: JF
authors: Strauss
mesh_terms: D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism; D015810:Linkage Disequilibrium; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D014481:United States