title: Therapeutic combination of sildenafil and iloprost in a preterm neonate with pulmonary hypertension.
abstract: While new pharmacological approaches have been demonstrated to effectively manage PH in adults, few reports have addressed PH treatment in neonates and infants. This case report describes the successful management of severe PH secondary to bronchopulmonary dysplasia, respiratory syncytial virus infection, and hypoxia in a preterm 4-month-old with the long-term use of orally administered sildenafil and inhaled iloprost.
authors: Division of Neonatology, Department of Pediatrics, American Hospital, Istanbul, Turkey.
authors: Berkan
authors: B
authors: Gürakan
authors: Petek
authors: P
authors: Kayiran
authors: Nilüfer
authors: N
authors: Oztürk
authors: Sinan Mahir
authors: SM
authors: Kayiran
authors: Aygün
authors: A
authors: Dindar
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D001997:Bronchopulmonary Dysplasia / Q000150:complications; D004359:Drug Therapy, Combination; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000860:Hypoxia / Q000150:complications; D016285:Iloprost / Q000008:administration & dosage / Q000627:therapeutic use*; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011687:Purines / Q000008:administration & dosage / Q000627:therapeutic use; D018357:Respiratory Syncytial Virus Infections / Q000150:complications; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D016285:Iloprost