title: HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation.
abstract: We and others have reported that HLA-DRB1*03 is associated with childhood asthma. To extend this observation and to prove this association, we sensitized and challenged either HLA-DR2 (HLA-DRB1*1502) or HLA-DR3 (HLA-DRB1*0301) transgenic mice with house-dust mite extract. Inflammatory cell counts and cytokine levels in the bronchoalveolar lavage (BAL) fluid between HLA-DR3 and DR2 mice were compared. HLA-DR3 transgenic mice had significantly elevated eosinophil counts, Interleukin-4 and Interleukin-13 levels in the BAL fluid but not interferron gamma-γ. Thus, our study suggests that HLA-DRB1*0301 plays an important role in mounting a Th2-predominant immune response to house dust mite and Th2-type inflammation in the lung.
authors: Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
authors: G
authors: G
authors: Rajagopalan
authors: A Y
authors: AY
authors: Tilahun
authors: K
authors: K
authors: Iijima
authors: C S
authors: CS
authors: David
authors: H
authors: H
authors: Kita
authors: Y J
authors: YJ
authors: Juhn
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D006684:HLA-DR Antigens / Q000235:genetics*; D015802:HLA-DR2 Antigen / Q000235:genetics*; D015803:HLA-DR3 Antigen / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007107:Immune System; D007249:Inflammation; D007371:Interferon-gamma / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D011110:Polymorphism, Genetic; D039981:Pyroglyphidae / Q000235:genetics*; D018418:Th2 Cells
chemical_list: D006684:HLA-DR Antigens; D015802:HLA-DR2 Antigen; D015803:HLA-DR3 Antigen; D059811:HLA-DRB1 Chains; C553502:HLA-DRB1*03:01 antigen; D018793:Interleukin-13; D015847:Interleukin-4; D007371:Interferon-gamma