title: Subgingival ultrasonic instrumentation of residual pockets irrigated with essential oils: a randomized controlled trial.
abstract: OBJECTIVE
  To evaluate the clinical efficacy of subgingival ultrasonic instrumentation irrigated with essential oils (EOs) of residual periodontal pockets.
  
  
  METHODS
  Sixty-four individuals with chronic periodontitis were invited to participate in this randomized, double-blind, parallel, and placebo-controlled clinical trial. All subjects received non-surgical periodontal therapy. After re-evaluation (baseline), residual pockets (pocket depth ≥5 mm) received test (ultrasonic instrumentation irrigated with EOs) or control therapy (ultrasonic instrumentation irrigated with negative control). Probing pocket depth (PPD), gingival recession (R), clinical attachment level (CAL), bleeding on probing (BOP), and plaque were assessed at baseline and after 4, 12, and 24 weeks. Differences between groups and changes over the course of time were analysed according to a generalized linear model.
  
  
  RESULTS
  There was a significant reduction in PPD and BOP, as well as a significant CAL gain in the two groups (p<0.001). Nevertheless, there were no differences between the groups at any time of the study. When only initially deep pockets (PPD ≥7 mm) were analysed, a significantly greater CAL gain (p=0.03) and PPD reduction (p=0.01) was observed in the test group.
  
  
  CONCLUSIONS
  The adjunctive use of EOs may promote significant CAL gain and PPD reduction in deep residual pockets.
authors: School of Dentistry, Division of Periodontics, University of São Paulo, São Paulo, Brazil.
authors: Hsu Shao
authors: HS
authors: Feng
authors: Carlos Cheque
authors: CC
authors: Bernardo
authors: Livia Lie
authors: LL
authors: Sonoda
authors: Fernando
authors: F
authors: Hayashi
authors: Giuseppe Alexandre
authors: GA
authors: Romito
authors: Luiz Antonio Pugliesi Alves
authors: LA
authors: De Lima
authors: Roberto Fraga Moreira
authors: RF
authors: Lotufo
authors: Claudio Mendes
authors: CM
authors: Pannuti
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000628:therapy; D003511:Cyclohexanols / Q000008:administration & dosage / Q000627:therapeutic use; D003773:Dental Plaque / Q000382:microbiology; D004311:Double-Blind Method; D004338:Drug Combinations; D000431:Ethanol / Q000008:administration & dosage / Q000627:therapeutic use; D000077591:Eucalyptol; D005052:Eucalyptus; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000628:therapy; D005889:Gingival Recession / Q000628:therapy; D006801:Humans; D008297:Male; D008610:Menthol / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D039821:Monoterpenes / Q000008:administration & dosage / Q000627:therapeutic use; D009822:Oils, Volatile / Q000008:administration & dosage / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000628:therapy; D010514:Periodontal Pocket / Q000628:therapy*; D010919:Placebos; D012459:Salicylates / Q000008:administration & dosage / Q000627:therapeutic use; D013357:Subgingival Curettage / Q000295:instrumentation*; D013729:Terpenes / Q000008:administration & dosage / Q000627:therapeutic use; D007507:Therapeutic Irrigation; D013943:Thymol / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000295:instrumentation*
chemical_list: D000891:Anti-Infective Agents, Local; D003511:Cyclohexanols; D004338:Drug Combinations; D039821:Monoterpenes; D009822:Oils, Volatile; D010919:Placebos; D012459:Salicylates; D013729:Terpenes; D008610:Menthol; D013943:Thymol; D000431:Ethanol; C057473:Listerine; C033069:methyl salicylate; D000077591:Eucalyptol