title: Serum gamma glutamyl transferase: a novel biomarker for screening of premature coronary artery disease.
abstract: BACKGROUND
  We aimed to elucidate the association between gamma glutamyl transferase (GGT) activity with prevalence of premature coronary artery disease (CAD) in young Pakistani patients undergoing diagnostic coronary angiography.
  
  
  METHODS
  A total of 218 young adults (age ≤ 45 years) underwent diagnostic angiography. Serum samples were taken from all the patients and analyzed for serum GGT activity, cholesterol and triglycerides.
  
  
  RESULTS
  Coronary artery disease patients had significantly increased GGT activity (P = .001) and exhibited a significant positive correlation with blood pressure, cholesterol, blood glucose, and smoking and negative correlation with total antioxidant status (P < .01).
  
  
  CONCLUSIONS
  The study revealed good diagnostic accuracy at cutoff of 35 U/L with a sensitivity of 92%, specificity of 81%, and diagnostic odds ratio of 48 in estimation of premature CAD in young Pakistanis.
authors: Department of Pathology, AMC, National University of Sciences and Technology, Rawalpindi, Pakistan.
authors: Saira
authors: S
authors: Shabbir
authors: Dilshad A
authors: DA
authors: Khan
authors: Farooq A
authors: FA
authors: Khan
authors: Maqsood M
authors: MM
authors: Elahi
authors: Bashir M
authors: BM
authors: Matata
mesh_terms: D000328:Adult; D017668:Age of Onset; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D004796:Clinical Enzyme Tests; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008403:Mass Screening / Q000379:methods*; D016017:Odds Ratio; D018384:Oxidative Stress; D010154:Pakistan / Q000453:epidemiology; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012907:Smoking / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood; D015854:Up-Regulation; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol; D005723:gamma-Glutamyltransferase