title: Focus issue: Rendering resistance futile.
abstract: In conjunction with the Science special issue on cancer (http://www.sciencemag.org/special/cancer2011/), this issue of Science Signaling focuses on mechanisms whereby cancer cells become resistant to antineoplastic therapy. This issue explores mechanisms whereby cancer cells can become resistant to classical chemotherapy drugs aimed at rapidly proliferating cells or to newer agents that depend on specific inhibition of oncogenic kinases or downstream components of aberrantly activated signaling pathways.
authors: Elizabeth M
authors: EM
authors: Adler
authors: Nancy R
authors: NR
authors: Gough
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D011494:Protein Kinases