title: The network approach for prevention of healthcare-associated infections: long-term effect of participation in the Duke Infection Control Outreach Network.
abstract: OBJECTIVE
  To describe the rates of several key outcomes and healthcare-associated infections (HAIs) among hospitals that participated in the Duke Infection Control Outreach Network (DICON).
  
  
  METHODS
  Prospective, observational cohort study of patients admitted to 24 community hospitals from 2003 through 2009.
  
  
  METHODS
  The following data were collected and analyzed: incidence of central line-associated bloodstream infections (CLABSIs), ventilator-associated pneumonia (VAP), catheter-associated urinary tract infections (CAUTIs), and HAIs caused by methicillin-resistant Staphylococcus aureus (MRSA); employee exposures to bloodborne pathogens (EBBPs); physician EBBPs; patient-days; central line-days; ventilator-days; and urinary catheter-days. Poisson regression was used to determine whether incidence rates of these HAIs and exposures changed during the first 5 and 7 years of participation in DICON; nonrandom clustering of each outcome was controlled for. Cost saved and lives saved were calculated on the basis of published estimates.
  
  
  RESULTS
  In total, we analyzed 6.5 million patient-days, 4,783 EBPPs, 2,948 HAIs due to MRSA, and 2,076 device-related infections. Rates of employee EBBPs, HAIs due to MRSA, and device-related infections decreased significantly during the first 5 years of participation in DICON (P< .05 for all models; average decrease was approximately 50%); in contrast, physician EBBPs remained unchanged. In aggregate, 210 CLABSIs, 312 cases of VAP, 332 CAUTIs, 1,042 HAIs due to MRSA, and 1,016 employee EBBPs were prevented. Each hospital saved approximately $100,000 per year of participation, and collectively the hospitals may have prevented 52-105 deaths from CLABSI or VAP. The 7-year analysis demonstrated that these trends continued with further participation.
  
  
  CONCLUSIONS
  Hospitals with long-term participation in an infection control network decreased rates of significant HAIs by approximately 50%, decreased costs, and saved lives.
authors: Duke Infection Control Outreach Network, Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. dja@duke.edu
authors: Deverick J
authors: DJ
authors: Anderson
authors: Becky A
authors: BA
authors: Miller
authors: Luke F
authors: LF
authors: Chen
authors: Linda H
authors: LH
authors: Adcock
authors: Evelyn
authors: E
authors: Cook
authors: A Lynn
authors: AL
authors: Cromer
authors: Susan
authors: S
authors: Louis
authors: Paul A
authors: PA
authors: Thacker
authors: Daniel J
authors: DJ
authors: Sexton
mesh_terms: D016470:Bacteremia / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D017848:Blood-Borne Pathogens; D055499:Catheter-Related Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D002404:Catheterization / Q000009:adverse effects; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*; D006764:Hospitals, Community / Q000191:economics / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D017053:Infection Control / Q000191:economics / Q000458:organization & administration*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D016273:Occupational Exposure / Q000706:statistics & numerical data; D010820:Physicians / Q000706:statistics & numerical data; D053717:Pneumonia, Ventilator-Associated / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D016012:Poisson Distribution; D011446:Prospective Studies; D012044:Regression Analysis; D015144:Southeastern United States / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology; D013997:Time Factors; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control