title: Ambulatory quantitative waking and sleeping cough assessment in patients with cystic fibrosis.
abstract: BACKGROUND
  Although cough is a commonly reported symptom, objective quantitation of cough during normal activity has not been performed in patients with CF.
  
  
  METHODS
  An ambulatory device was used to characterize cough over 24 hours. Pulmonary function and subject-reported coughing were also assessed.
  
  
  RESULTS
  Patients included 19 clinically stable adults with CF (males:females=10:9; median age [range]=26 [19-57] years; median %-predicted FEV(1) [range]=65 [44-106]%). Median [range] cough rate was 27 [13-66] coughs/hour, with values while awake of 41 [20-102] and while asleep of 2 [0.1-7] (p<0.0001, Wilcoxon signed-rank test). Subjective reporting was consistent with objective data for wake-sleep differences, but correlated poorly with objective waking cough rate.
  
  
  CONCLUSIONS
  Outpatient cough quantitation in patients with CF is feasible, indicates frequent coughing even during clinical stability, and may be useful in therapeutic trials in CF.
authors: Hadassah Hebrew University Medical Center, Jerusalem, Israel. ek@cc.huji.ac.il
authors: Eitan
authors: E
authors: Kerem
authors: Michael
authors: M
authors: Wilschanski
authors: Nilsen L
authors: NL
authors: Miller
authors: Thea
authors: T
authors: Pugatsch
authors: Tali
authors: T
authors: Cohen
authors: Hannah
authors: H
authors: Blau
authors: Joseph
authors: J
authors: Rivlin
authors: David
authors: D
authors: Shoseyov
authors: Allen
authors: A
authors: Reha
authors: Scott
authors: S
authors: Constantine
authors: Temitayo
authors: T
authors: Ajayi
authors: Samit
authors: S
authors: Hirawat
authors: Gary L
authors: GL
authors: Elfring
authors: Stuart W
authors: SW
authors: Peltz
authors: Langdon L
authors: LL
authors: Miller
mesh_terms: D000328:Adult; D003371:Cough / Q000209:etiology* / Q000503:physiopathology; D003550:Cystic Fibrosis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D005240:Feasibility Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000009:adverse effects; D010349:Patient Compliance; D012890:Sleep; D013997:Time Factors; D014851:Wakefulness; D055815:Young Adult