title: Enhanced anti-cancer effect of 5-fluorouracil loaded into thermo-responsive conjugated linoleic acid-incorporated poloxamer hydrogel on metastatic colon cancer models.
abstract: Conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) is an effective drug delivery system with numerous advantages and anti-cancer activity. 5-FU administered in Plu-CLA hydrogel (P-FU) led to the significant enhancement of tumor growth suppression and cellular apoptosis. Moreover, growth of hepatic and intraperitoneal metastases in vivo was significantly reduced in mice treated with P-FU. Therefore, Plu-CLA could be a potential intraperitoneal carrier for hydrophilic 5-FU for the effective treatment of metastatic colon cancer.
authors: Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun-Gun, Jeollanamdo 519-809, South Korea.
authors: Woo Kyun
authors: WK
authors: Bae
authors: Ji Hee
authors: JH
authors: Lee
authors: Sang Joon
authors: SJ
authors: Lee
authors: Myong Suk
authors: MS
authors: Park
authors: Jun Eul
authors: JE
authors: Hwang
authors: Hyun Jeong
authors: HJ
authors: Shim
authors: Sang Hee
authors: SH
authors: Cho
authors: Ding-Ding
authors: DD
authors: Guo
authors: Chong-Su
authors: CS
authors: Cho
authors: In-Kyu
authors: IK
authors: Park
authors: Ik Joo
authors: IJ
authors: Chung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016503:Drug Delivery Systems; D005472:Fluorouracil / Q000008:administration & dosage*; D020100:Hydrogels / Q000008:administration & dosage; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000556:secondary; D051379:Mice; D008807:Mice, Inbred BALB C; D036103:Nanotechnology; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000556:secondary; D020442:Poloxamer / Q000008:administration & dosage; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D020100:Hydrogels; D044243:Linoleic Acids, Conjugated; D019253:Proto-Oncogene Proteins c-bcl-2; D020442:Poloxamer; C505409:Casp3 protein, mouse; D053148:Caspase 3; D005472:Fluorouracil