title: The immunohistochemical profile of oral inflammatory myofibroblastic tumors.
abstract: OBJECTIVE
  The aim of this study was to demonstrate the immunohistochemical profile of oral inflammatory myofibroblastic tumors (IMTs) along with morphologic analysis.
  
  
  METHODS
  Three cases diagnosed as oral IMTs were selected to compile an immunohistochemical panel constituted by calponin, caldesmon, Bcl-2, desmin, fibronectin, CD68, Ki-67, S100, anaplastic lymphoma kinase (ALK), α-smooth muscle actin, cytokeratins AE1/AE3, muscle-specific actin, CD34, and vimentin. An oral squamous cell carcinoma with a focal area of desmoplastic stroma was used as control for the stained myofibroblastic cells.
  
  
  RESULTS
  All oral IMTs were positive for calponin, revealing a strong and diffuse expression in the spindle-shaped cells. The lesions were also positive for vimentin (3/3), fibronectin (3/3), α-smooth muscle actin (3/3), and muscle-specific actin (1/3) and negative for h-caldesmon, Bcl-2, desmin, CD68, Ki-67, S100, ALK, cytokeratins AE1/AE3, and CD34.
  
  
  CONCLUSIONS
  Within the results encountered, the present panel should be of great assistance in the diagnosis of oral IMTs.
authors: Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil. fernandagiudice@usp.br
authors: Fernanda
authors: F
authors: Salgueiredo-Giudice
authors: Felipe
authors: F
authors: Fornias-Sperandio
authors: Erika
authors: E
authors: Martins-Pereira
authors: Aluana Maria
authors: AM
authors: da Costa dal Vechio
authors: Suzana Cantanhede Orsini Machado
authors: SC
authors: de Sousa
authors: Décio
authors: D
authors: dos Santos-Pinto-Junior
mesh_terms: D000199:Actins / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008840:Microfilament Proteins / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D058628:Myofibroblasts / Q000378:metabolism / Q000473:pathology*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009379:Neoplasms, Muscle Tissue / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism; D000096985:Calponins
chemical_list: D000199:Actins; D002135:Calcium-Binding Proteins; D005353:Fibronectins; D008840:Microfilament Proteins; D009363:Neoplasm Proteins; D014746:Vimentin; D000096985:Calponins; C541116:ACTA2 protein, human