title: Remembering one's identity: the epigenetic basis of stem cell fate decisions.
abstract: Stem cells serve a vital role in multicellular organisms by constantly replenishing tissue with their differentiated progeny during normal homeostasis or damage. How these cells maintain their identities throughout the life of an organism is an area of intense research. In this review, we explore recent emerging evidence that stem cell fate decisions are based on their epigenome and specific epigenetic factors.
authors: Division of Dermatology, Department of Medicine, University of California, San Diego, California, USA. gsen@ucsd.edu
authors: George L
authors: GL
authors: Sen
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D019175:DNA Methylation; D015257:DNA-Cytosine Methylases / Q000378:metabolism; D056466:Histone Demethylases / Q000378:metabolism; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D008745:Methylation; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*
chemical_list: D006657:Histones; D056466:Histone Demethylases; D015257:DNA-Cytosine Methylases; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase