title: Nanomedicine: making controllable magnetic drug delivery possible for the treatment of breast cancer.
abstract: A recent study published in Nano Letters documents the synthesis and performance of porous silica nanocapsules filled with magnetic nanoparticles as a controllable magnetic drug delivery vector. Under a remotely applied radiofrequency magnetic field, these nanocapsules demonstrate on-off switchable release of the internally loaded drug payload. Both in vitro and in vivo studies using MT2 mouse breast cancer cell models demonstrate that the magnetic targeting of these nanocapsules allows for deep tumor penetration and subsequent on-demand release of the drug cargo, significantly reducing tumor cell viability.
authors: Department of Chemistry and the Richard E Smalley Institute for Nanoscale Science and Technology, Rice University, Houston, TX 77005, USA.
authors: Lesa A
authors: LA
authors: Tran
authors: Lon J
authors: LJ
authors: Wilson
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D006801:Humans; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D051379:Mice; D053769:Nanocapsules; D050997:Nanomedicine / Q000379:methods*
chemical_list: D058185:Magnetite Nanoparticles; D053769:Nanocapsules