title: What is the cost of pelvic inflammatory disease and how much could be prevented by screening for chlamydia trachomatis? Cost analysis of the Prevention of Pelvic Infection (POPI) trial.
abstract: OBJECTIVE
  To describe healthcare settings attended by women with clinical pelvic inflammatory disease (PID), to calculate the cost of a PID episode and to estimate how many cases could be prevented in London annually at current chlamydia screening levels.
  
  
  METHODS
  An ethnically diverse sample of 2259 16-24 year old, sexually active, female London students were recruited to a chlamydia screening trial in 2004-2006 of whom 94% (2115) were followed up after 12 months for incidence of PID. A cost analysis examined healthcare settings attended by women with PID, the cost of an episode of PID and the number of cases of PID in London due to untreated chlamydia at baseline that could be prevented per year at 2009 annual screening levels.
  
  
  RESULTS
  Of 35 PID cases, 17 (47%) first presented in general practice, 15 (42%) at a genitourinary medicine clinic, two elsewhere and one was admitted to hospital. The average number of consultations for a PID episode was 2.0 (range 1-4) and the average cost was £163 (range £29-960). Assuming 414,345 sexually active women aged 16-24 in London, 6% chlamydia prevalence at baseline and a 7.3% difference in PID rates between screened and unscreened chlamydia positives, 391 (95% CI--44 to 882) cases of chlamydia-associated PID costing £63,733 could be prevented each year in London at 21.5% 2009 annual screening levels.
  
  
  CONCLUSIONS
  Most women with PID were managed in the community. The number and cost of PID cases prevented by a single annual chlamydia screen is low suggesting that cost effectiveness may depend mainly on the prevention of long-term sequelae.
authors: Population Health Sciences and Education, St. George's, University of London, London, UK. aaghaizu@sgul.ac.uk
authors: Adamma
authors: A
authors: Aghaizu
authors: Elisabeth J
authors: EJ
authors: Adams
authors: Katy
authors: K
authors: Turner
authors: Sally
authors: S
authors: Kerry
authors: Phillip
authors: P
authors: Hay
authors: Ian
authors: I
authors: Simms
authors: Pippa
authors: P
authors: Oakeshott
mesh_terms: D000293:Adolescent; D002690:Chlamydia Infections / Q000191:economics* / Q000517:prevention & control; D002692:Chlamydia trachomatis; D017281:Cost of Illness; D003365:Costs and Cost Analysis; D005260:Female; D006801:Humans; D015994:Incidence; D008131:London / Q000453:epidemiology; D008403:Mass Screening / Q000191:economics*; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data; D000292:Pelvic Inflammatory Disease / Q000191:economics* / Q000382:microbiology / Q000517:prevention & control; D015995:Prevalence; D011788:Quality of Life; D055815:Young Adult