title: Management of early hepatic arterial thrombosis after pediatric living-donor liver transplantation.
abstract: OBJECTIVE
  Early hepatic arterial thrombosis after living-donor liver transplantation is a cause of graft loss and patient mortality. We analyzed early hepatic arterial thrombosis after pediatric living-donor liver transplantation.
  
  
  METHODS
  Since September 2001, we performed 122 living-donor liver transplants on 119 children. Ten hepatic arterial thromboses developed in the early postoperative period. The 7 male and 4 female patients of overall mean age of 6.3±6.1 years underwent 5 left lateral segment, 3 right lobe, and 2 left lobe transplantations.
  
  
  RESULTS
  Among 10 children with hepatic arterial thrombosis, 8 diagnoses were made before any elevation of liver function tests. One child displayed fever at the time of the hepatic arterial thrombosis. The median time for diagnosis was 5 days. Hepatic arterial thrombosis was treated with interventional radiologic techniques in 9 children, with 1 undergoing surgical exploration owing to failed radiologic approaches, and a reanastomosis using a polytetrafluoroethylene graft. Successful revascularization was achieved in all children, except 1. Four children died, the remaining 6 are alive with good graft function. During the mean follow-up of 52.7±18.8 months, multiple intrahepatic biliary stenoses were identified in 1 child.
  
  
  CONCLUSIONS
  Routine Doppler ultrasonography is effective for the early diagnosis of hepatic arterial thrombosis. Interventional radiologic approaches such as arterial thrombolysis and intraluminal stent placement should be the first therapeutic choices for patients with early hepatic arterial thrombosis; if radiologic methods fail, one must consider surgical exploration or retransplantation.
authors: Department of General Surgery, Başkent University Faculty of Medicine, Ankara, Turkey.
authors: S
authors: S
authors: Sevmis
authors: H
authors: H
authors: Karakayali
authors: N U
authors: NU
authors: Tutar
authors: F
authors: F
authors: Boyvat
authors: F
authors: F
authors: Ozcay
authors: A
authors: A
authors: Torgay
authors: M
authors: M
authors: Haberal
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection; D006499:Hepatic Artery / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D010372:Pediatrics / Q000379:methods; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000628:therapy*; D018608:Ultrasonography, Doppler / Q000379:methods