title: Ferruginenes A-C from Rhododendron ferrugineum and their cytotoxic evaluation.
abstract: Three new compounds, ferruginenes A (1) and B (2) and a mixture of C-5'(R) and C-5'(S) ferruginene C (3) diastereomers, have been isolated from a cytotoxic chloroform-soluble fraction of the leaves of Rhododendron ferrugineum together with 12 known compounds. The structures of these new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometric data. Compounds 1-3 were tested for their cytotoxicity against three human cancer cell lines, namely, HL-60, HeLa-S3, and MCF-7.
authors: Center of Excellence for Innovation in Chemistry (PERCH-CIC) and Department of Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham, 44150 Thailand.
authors: Prapairat
authors: P
authors: Seephonkai
authors: Ruxandra
authors: R
authors: Popescu
authors: Martin
authors: M
authors: Zehl
authors: Georg
authors: G
authors: Krupitza
authors: Ernst
authors: E
authors: Urban
authors: Brigitte
authors: B
authors: Kopp
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001317:Austria; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006367:HeLa Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D029793:Rhododendron / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D006575:Heterocyclic Compounds, 3-Ring; C559164:ferruginene A; C559162:ferruginene B; C559163:ferruginene C