title: Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne cycloaddition reaction.
abstract: The internal modification of RNA has been successfully achieved by the functionality transfer reaction (FTR) and following click chemistry with diverse azide compounds. The benefits of the FTR have been demonstrated by its specificity, rapidity, broad applicability, and procedure simplicity.
authors: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan.
authors: Kazumitsu
authors: K
authors: Onizuka
authors: Atsushi
authors: A
authors: Shibata
authors: Yosuke
authors: Y
authors: Taniguchi
authors: Shigeki
authors: S
authors: Sasaki
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D057930:Click Chemistry / Q000379:methods*; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D006151:Guanosine / Q000031:analogs & derivatives / Q000032:analysis / Q000737:chemistry; D006801:Humans; D009693:Nucleic Acid Hybridization; D015341:Nucleic Acid Probes / Q000737:chemistry* / Q000378:metabolism; D012313:RNA / Q000032:analysis* / Q000737:chemistry; D013872:Thionucleosides / Q000032:analysis / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D015341:Nucleic Acid Probes; D013872:Thionucleosides; D006151:Guanosine; D012313:RNA; D003300:Copper; C005783:6-thioguanosine