title: Testing the involvement of baroreflex during general anesthesia through Granger causality approach.
abstract: Baroreflex sensitivity (BRS) is commonly assessed from spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) during general anesthesia. Unfortunately, general anesthesia depresses autonomic function and, consequently, spontaneous SAP variations could not be capable to drive HP changes, thus preventing the use of spontaneous variability to infer BRS. We applied two Granger causality approaches (F-test and Wald test) during two anesthesiological strategies (i.e. sevoflurane plus remifentanil or propofol plus remifentanil). We found a significant Granger-causality from SAP to HP independently of the anesthesiological strategy; thus suggesting that techniques estimating BRS from spontaneous variability can be utilized during general anesthesia.
authors: Department of Technologies for Health, Galeazzi Orthopaedic Institute, University of Milan, Milan, Italy.
authors: Tito
authors: T
authors: Bassani
authors: Valentina
authors: V
authors: Magagnin
authors: Stefano
authors: S
authors: Guzzetti
authors: Giuseppe
authors: G
authors: Baselli
authors: Giuseppe
authors: G
authors: Citerio
authors: Alberto
authors: A
authors: Porta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General / Q000379:methods*; D000777:Anesthetics; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D003198:Computer Simulation; D003399:Craniotomy; D004562:Electrocardiography; D006801:Humans; D008738:Methyl Ethers; D008875:Middle Aged; D008955:Models, Cardiovascular; D015233:Models, Statistical; D010880:Piperidines; D015742:Propofol; D012044:Regression Analysis; D000077208:Remifentanil; D000077149:Sevoflurane; D012815:Signal Processing, Computer-Assisted; D018709:Statistics, Nonparametric
chemical_list: D000777:Anesthetics; D008738:Methyl Ethers; D010880:Piperidines; D000077149:Sevoflurane; D000077208:Remifentanil; D015742:Propofol