title: Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America.
abstract: Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%), and 4O (1.7%).
authors: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
authors: Pushpendra
authors: P
authors: Singh
authors: Philippe
authors: P
authors: Busso
authors: Alberto
authors: A
authors: Paniz-Mondolfi
authors: Nacarid
authors: N
authors: Aranzazu
authors: Marc
authors: M
authors: Monot
authors: Nadine
authors: N
authors: Honore
authors: Andrea
authors: A
authors: de Faria Fernandes Belone
authors: Marcos
authors: M
authors: Virmond
authors: Maria Esther
authors: ME
authors: Villarreal-Olaya
authors: Carlos
authors: C
authors: Rivas
authors: Stewart T
authors: ST
authors: Cole
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D024881:Drug Resistance, Bacterial; D005260:Female; D005838:Genotype; D006801:Humans; D007918:Leprosy / Q000188:drug therapy; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D013020:South America