title: Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.
abstract: Amyloid-β(1-42) (Aβ) is thought to be a major mediator of the cognitive deficits in Alzheimer's disease. The ability of Aβ to inhibit hippocampal long-term potentiation provides a cellular correlate of this action, but the underlying molecular mechanism is only partially understood. We found that a signaling pathway involving caspase-3, Akt1 and glycogen synthase kinase-3β is an important mediator of this effect in rats and mice.
authors: Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK.
authors: Jihoon
authors: J
authors: Jo
authors: Daniel J
authors: DJ
authors: Whitcomb
authors: Kimberly Moore
authors: KM
authors: Olsen
authors: Talitha L
authors: TL
authors: Kerrigan
authors: Shih-Ching
authors: SC
authors: Lo
authors: Gilles
authors: G
authors: Bru-Mercier
authors: Bryony
authors: B
authors: Dickinson
authors: Sarah
authors: S
authors: Scullion
authors: Morgan
authors: M
authors: Sheng
authors: Graham
authors: G
authors: Collingridge
authors: Kwangwook
authors: K
authors: Cho
mesh_terms: D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001703:Biophysics; D053148:Caspase 3 / Q000172:deficiency / Q000378:metabolism*; D004558:Electric Stimulation / Q000379:methods; D004791:Enzyme Inhibitors / Q000494:pharmacology; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D049452:Green Fluorescent Proteins / Q000235:genetics; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009924:Organ Culture Techniques; D018408:Patch-Clamp Techniques; D010446:Peptide Fragments / Q000494:pharmacology*; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D011725:Pyridines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D014162:Transfection / Q000379:methods; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; C473711:Chir 99021; D004791:Enzyme Inhibitors; D010446:Peptide Fragments; D011725:Pyridines; D011743:Pyrimidines; D051636:X-Linked Inhibitor of Apoptosis Protein; C075222:amyloid beta-protein (1-42); D049452:Green Fluorescent Proteins; C514862:Akt1 protein, mouse; D000071679:Glycogen Synthase Kinase 3 beta; C000605507:Gsk3b protein, mouse; C000605508:Gsk3b protein, rat; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3; D053148:Caspase 3