title: Aptamers and the RNA world, past and present.
abstract: Aptamers and the SELEX process were discovered over two decades ago. These discoveries have spawned a productive academic and commercial industry. The collective results provide insights into biology, past and present, through an in vitro evolutionary exploration of the nature of nucleic acids and their potential roles in ancient life. Aptamers have helped usher in an RNA renaissance. Here we explore some of the evolution of the aptamer field and the insights it has provided for conceptualizing an RNA world, from its nascence to our current endeavor employing aptamers in human proteomics to discover biomarkers of health and disease.
authors: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA. lgold@somalogic.com
authors: Larry
authors: L
authors: Gold
authors: Nebojsa
authors: N
authors: Janjic
authors: Thale
authors: T
authors: Jarvis
authors: Dan
authors: D
authors: Schneider
authors: Jeffrey J
authors: JJ
authors: Walker
authors: Sheri K
authors: SK
authors: Wilcox
authors: Dom
authors: D
authors: Zichi
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D015415:Biomarkers / Q000097:blood / Q000737:chemistry; D049673:History, 20th Century; D006801:Humans; D040901:Proteomics / Q000379:methods; D012313:RNA / Q000737:chemistry* / Q000502:physiology; D052156:SELEX Aptamer Technique / Q000266:history*
chemical_list: D052157:Aptamers, Nucleotide; D015415:Biomarkers; D012313:RNA