title: Sulphilimine cross-links in Goodpasture's disease.
abstract: The sulphilimine cross-link of the Goodpasture (GP) autoantigen is a novel molecular mechanism (structural constraint) for conferring immune privilege to a site which otherwise is susceptible to structural changes that induce an immunogenic and pathogenic conformation. Perturbation of the assembly or cleavage of the sulphilimine cross-links could be a key factor in the aetiology of Goodpasture's disease in susceptible individuals.
authors: Division of Nephrology & Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-2372, USA. roberto.vanacore@vanderbilt.edu
authors: R
authors: R
authors: Vanacore
authors: V
authors: V
authors: Pedchenko
authors: G
authors: G
authors: Bhave
authors: B G
authors: BG
authors: Hudson
mesh_terms: D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology*; D001324:Autoantigens / Q000737:chemistry* / Q000276:immunology*; D024141:Collagen Type IV / Q000737:chemistry* / Q000276:immunology*; D003432:Cross-Linking Reagents / Q000737:chemistry; D018985:Epitopes, B-Lymphocyte / Q000737:chemistry / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry / Q000276:immunology; D006801:Humans; D011487:Protein Conformation
chemical_list: D001324:Autoantigens; D024141:Collagen Type IV; D003432:Cross-Linking Reagents; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; C057112:type IV collagen alpha3 chain