title: Effect of virgin fatty oil of Pistacia lentiscus on experimental burn wound's healing in rabbits.
abstract: This study aimed to assess the efficiency of the virgin fatty oil of Pistacia lentiscus (PLVFO) for burn wounds healing. It was carried out on 6 adult male New Zealand rabbits. Four burn wounds of deep third degree were made on the back of each animal. The first was not treated and served as control (CRL group); the others were covered immediately after burning procedure by 0.5g of one of the following products: Vaseline gel (VAS group), Madecassol(®) cream 1% (MAD group) or 1ml of PLVFO (PLVFO group). The treatments were repeated once daily until complete healing. For four days post burns, the percentage of wound contraction was assessed. Also, the different healing times were noted. The results showed that both PLVFO and Madecassol(®) significantly accelerated wound healing activity compared to wounds dressed with Vaseline and the untreated wounds. However, the level of wound contraction was significantly higher and the healing time was faster in PLVFO group than those of the MAD group, VAS group and CRL group. The different epithelization periods obtained in days were respectively: 30±3.94 (PLVFO group), 33.5±3.78 (MAD group), 34.66±3.88 (VAS group) and 37.16±3.54 (CRL group). We conclude that Pistacia lentiscus virgin fatty oil promotes significantly (p< 0.05) wound contraction and reduces epithelization period in rabbit model.
authors: Department of Veterinary Sciences, Pharmacotoxicology Laboratory, Mentouri Constantine University, Algeria. Zouhir21265@yahoo.fr
authors: Zouhir
authors: Z
authors: Djerrou
authors: Z
authors: Z
authors: Maameri
authors: Y
authors: Y
authors: Hamdi-Pacha
authors: M
authors: M
authors: Serakta
authors: F
authors: F
authors: Riachi
authors: H
authors: H
authors: Djaalab
authors: A
authors: A
authors: Boukeloua
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002056:Burns / Q000628:therapy; D008297:Male; D010577:Petrolatum / Q000627:therapeutic use; D008517:Phytotherapy; D027927:Pistacia / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D028321:Plant Preparations / Q000494:pharmacology*; D011817:Rabbits; D012639:Seeds; D014315:Triterpenes / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D010938:Plant Oils; D028321:Plant Preparations; D014315:Triterpenes; D010577:Petrolatum; C004446:asiaticoside