title: Migraine prophylaxis with topiramate and bone health in women.
abstract: Antiepileptic drugs (AEDs) are commonly used for prevention of migraine headaches. Bone loss is a known complication, particularly associated with use of older AEDs. Topiramate is a newer AED, widely used for migraine prevention, but no evidence is currently available on its effect on bone metabolism. In a clinic-based pilot study, we evaluated bone health by examining biochemical and radiological markers of bone metabolism, in women with migraine. Osteopenia was noted in 53% of the patients and was associated with the duration of exposure to topiramate (P = .04).
authors: Department of Neurology, University of Toledo College of Medicine, Toledo, OH, USA.
authors: Imran I
authors: II
authors: Ali
authors: Nabeel A
authors: NA
authors: Herial
authors: Megan
authors: M
authors: Orris
authors: Terrance
authors: T
authors: Horrigan
authors: Gretchen E
authors: GE
authors: Tietjen
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects; D001851:Bone Diseases, Metabolic / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D001842:Bone and Bones / Q000502:physiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000517:prevention & control*; D010865:Pilot Projects; D012737:Sex Factors; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose