title: Monitoring pulmonary function during exercise in children with asthma.
abstract: OBJECTIVE
  Exercise-induced bronchoconstriction (EIB) is defined as acute, reversible bronchoconstriction induced by physical exercise. It is widely believed that EIB occurs after exercise. However, in children with asthma the time to maximal bronchoconstriction after exercise is short, suggesting that the onset of EIB in such children occurs during exercise.
  
  
  OBJECTIVE
  In this study the authors investigate pulmonary function during exercise in cold air in children with asthma.
  
  
  METHODS
  33 Children with asthma with a mean age of 12.3 years and a clinical history of exercise induced symptoms, underwent a prolonged, submaximal, exercise test of 12 min duration at approximately 80% of the predicted maximum heart rate. Pulmonary function was measured before and each minute during exercise. If EIB occurred (fall in forced expiratory volume in 1 s >15% from baseline), exercise was terminated and salbutamol was administered.
  
  
  RESULTS
  19 Children showed EIB. In 12 of these children bronchoconstriction occurred during exercise (breakthrough EIB), while seven children showed bronchoconstriction immediately after exercise (non-breakthrough EIB). Breakthrough EIB occurred between 6 and 10 min of exercise (mean 7.75 min).
  
  
  CONCLUSIONS
  In the majority of children with EIB in this study (ie, 12 out of 19), bronchoconstriction started during, and not after, a submaximal exercise test.
authors: Medisch Spectrum Twente, VKC Poli 17, Haaksbergerstraat 55, Enschede, The Netherlands. vanleeuwen.janneke@gmail.com
authors: Janneke C
authors: JC
authors: van Leeuwen
authors: Jean M M
authors: JM
authors: Driessen
authors: Frans H C
authors: FH
authors: de Jongh
authors: Wim M C
authors: WM
authors: van Aalderen
authors: Boony J
authors: BJ
authors: Thio
mesh_terms: D000293:Adolescent; D001250:Asthma, Exercise-Induced / Q000503:physiopathology*; D016084:Bronchoconstriction / Q000502:physiology; D002648:Child; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D013147:Spirometry / Q000379:methods