title: Oxidative aromatic C-N bond formation: convenient synthesis of N-amino-3-nitrile-indoles via FeBr3-mediated intramolecular cyclization.
abstract: A variety of functionalized N-amino-3-nitrile-indole derivatives are obtained via an intramolecular hetero-cyclization of 2-aryl-3-substituted hydrazono-alkylnitriles using FeBr(3) as a single electron oxidant. This approach allows the N-moiety on the side-chain to be annulated to the benzene ring during the final synthetic step via direct oxidative aromatic C-N bond formation.
authors: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P R China.
authors: Zisheng
authors: Z
authors: Zheng
authors: Lina
authors: L
authors: Tang
authors: Yanfeng
authors: Y
authors: Fan
authors: Xiuxiang
authors: X
authors: Qi
authors: Yunfei
authors: Y
authors: Du
authors: Daisy
authors: D
authors: Zhang-Negrerie
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D005290:Ferric Compounds / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007536:Isomerism; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D005290:Ferric Compounds; D007211:Indoles; D002244:Carbon; D009584:Nitrogen