title: A one and a two … expanding roles for poly(ADP-ribose) polymerases in metabolism.
abstract: In two related papers in this issue, Bai et al. (2011a, 2011b) observe that PARP-1- or PARP-2-deficient mice show increased energy expenditure and protection against diet-induced obesity. This metabolic phenotype is achieved, in part, through SIRT1 activation, either by increasing NAD(+) levels or by promoting SIRT1 expression.
authors: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, J7.104C, Dallas, TX 75390, USA.
authors: Xin
authors: X
authors: Luo
authors: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, J7.104C, Dallas, TX 75390, USA. Electronic address: lee.kraus@utsouthwestern.edu.
authors: W Lee
authors: WL
authors: Kraus