title: [Functional degradation of myelin basic protein. Proteomic approach].
abstract: Proteolytic degradation of autoantigens is of prime importance in current biochemistry and immunology. The most fundamental issue in this field is the functional role of peptides produced when the specificity of hydrolysis changes during the shift from health to disease and from normal state to pathology. The identification of specific peptide fragments in many cases proposes the diagnostic and prognostic criterion in the pathology progression. The aim of this work is comparative study of the degradation peculiarities of one of the main neuroantigen, myelin basic protein by proteases, activated during progress of pathological demyelinating process, and by proteasome of different origin. The comparison of specificity of different studied biocatalysts gives reason to discuss the critical change in the set of myelin basic protein fragments capable to be presented by major histocompatibility complex class I during neurodegeneration, which can promote the progress of autoimmune pathological process.
authors: A V
authors: AV
authors: Bacheva
authors: A A
authors: AA
authors: Belogurov
authors: E S
authors: ES
authors: Kuzina
authors: M V
authors: MV
authors: Serebriakova
authors: N A
authors: NA
authors: Ponomarenko
authors: V D
authors: VD
authors: Knorre
authors: V M
authors: VM
authors: Govorun
authors: A G
authors: AG
authors: Gabibov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002154:Calpain / Q000378:metabolism; D002402:Cathepsin D / Q000378:metabolism; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D040901:Proteomics; D014357:Trypsin / Q000378:metabolism
chemical_list: D004676:Myelin Basic Protein; D010446:Peptide Fragments; D010447:Peptide Hydrolases; D014357:Trypsin; D002154:Calpain; D002402:Cathepsin D; D019278:Matrix Metalloproteinase 3; D020780:Matrix Metalloproteinase 9; D046988:Proteasome Endopeptidase Complex