title: Recent advances in apoptosis, mitochondria and drug resistance in cancer cells.
abstract: Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough understanding of apoptotic signaling pathways and insights into apoptosis resistance mechanisms are imperative to unravel novel drug targets for the design of more effective and target selective therapeutic strategies. This review aims at providing an overview of the recent understanding of apoptotic signaling pathways, the main mechanisms by which cancer cells resist apoptotic insults, and discusses some recent attempts to target the mitochondrion for restoring efficient cell death signaling in cancer cells.
authors: Apoptosis, ROS and Cancer Biology Program, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore.
authors: Inthrani R
authors: IR
authors: Indran
authors: Grégory
authors: G
authors: Tufo
authors: Shazib
authors: S
authors: Pervaiz
authors: Catherine
authors: C
authors: Brenner
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D019008:Drug Resistance, Neoplasm / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008495:Medical Oncology / Q000639:trends; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D012106:Research / Q000639:trends
chemical_list: D000970:Antineoplastic Agents