title: Multiple thromboemboli associated to two occult tumors: a case mimicking catastrophic antiphospholipid syndrome.
abstract: Thromboembolic events tend to arise during the natural lifetime of tumors. However, multiple thromboemboli mimicking catastrophic antiphospholipid syndrome is quite rare as a first manifestation of a tumor. Herein we describe the case of a 51-year old woman that presented with multiple thromboemboli affecting her brain, lung and kidneys. Despite bolus administration of corticosteroids, anticoagulant therapy and immunoglobulin infusion treatment, the patient died. She had suffered from two occult tumors, which could not be identified premortem: a lung adenocarcinoma and an intrahepatic cholangiocarcinoma. This case underscores the importance of determining the underlying etiology behind multiple thromboemboli. The most important prognostic factor is rapid initiation of treatment of the multiple thromboemboli, emphasizing treatment of their etiology.
authors: Servicio de Reumatologia, Parc de Salut MAR, Universitat Autonoma de Barcelona, Spain. juanmunozortego@gmail.com
authors: Juan
authors: J
authors: Muñoz-Ortego
authors: Luisa
authors: L
authors: Blanco Lopez
authors: Jordi
authors: J
authors: Carbonell Abello
authors: Jordi
authors: J
authors: Monfort Faure
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000175:diagnosis*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D002388:Catastrophic Illness; D018281:Cholangiocarcinoma / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000175:diagnosis*; D008175:Lung Neoplasms / Q000175:diagnosis*; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis*; D013923:Thromboembolism / Q000175:diagnosis*
chemical_list: D000925:Anticoagulants; D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous