title: Maropitant citrate for treatment of ulcerative dermatitis in mice with a C57BL/6 background.
abstract: Murine ulcerative dermatitis (UD) is a common progressive condition of mice with a C57BL/6 background. Typically, mice present with scabs and crusts on the skin of the dorsal neck and ears, and are often severely pruritic. Animals tend to scratch the lesions, causing additional trauma to the already ulcerated and inflamed skin. Therapeutic intervention largely has been unsuccessful, in part due to the lack of a known cause for the disease. Though the exact etiology of UD has not been elucidated, substance P (SP) has recently been demonstrated as an important neuropeptide linked to the itch-scratch cycle. SP functions at the tachykinin neurokinin 1 (NK1) receptor. We hypothesized that inhibition of SP binding to the NK1 receptor would decrease the itch sensation, thus decreasing scratching behavior and subsequent skin trauma. The purpose of this study was to evaluate the effectiveness of an NK1 receptor antagonist, maropitant citrate, as a treatment for murine UD. Treatment with 1 mg/kg maropitant citrate significantly reduced the size of UD lesions in mice.
authors: Section of Comparative Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA. mwilliamsfritze@mcg.edu
authors: Misty J
authors: MJ
authors: Williams-Fritze
authors: Jodi A
authors: JA
authors: Carlson Scholz
authors: Caroline
authors: C
authors: Zeiss
authors: Yanhong
authors: Y
authors: Deng
authors: Steven R
authors: SR
authors: Wilson
authors: Rebekah
authors: R
authors: Franklin
authors: Peter C
authors: PC
authors: Smith
mesh_terms: D000818:Animals; D000982:Antipruritics / Q000494:pharmacology / Q000627:therapeutic use*; D003872:Dermatitis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D064729:Neurokinin-1 Receptor Antagonists; D011537:Pruritus / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary; D011812:Quinuclidines / Q000494:pharmacology / Q000627:therapeutic use*; D012376:Rodent Diseases / Q000188:drug therapy*; D012883:Skin Ulcer / Q000188:drug therapy / Q000662:veterinary; D013373:Substance P / Q000037:antagonists & inhibitors
chemical_list: D000982:Antipruritics; D064729:Neurokinin-1 Receptor Antagonists; D011812:Quinuclidines; D013373:Substance P; C518176:maropitant