title: Chemical biology of abscisic acid.
abstract: Chemical biology is a discipline that utilizes chemicals to elucidate biological mechanisms and physiological functions. Various abscisic acid (ABA) derivatives have revealed the structural requirement for the perception by ABA receptors while biotin or caged derivatives of ABA have disclosed the localization of several ABA-binding proteins. Recently, selective ABA agonist has been used to identify ABA receptors. Furthermore, ABA biosynthesis and catabolic inhibitors have contributed to the identification of new ABA functions in plant growth and development. The physiological function of ABA in non-plant organisms has gradually been revealed. In this review, we discuss the development of small bioactive chemicals and their significance in ABA research.
authors: Department of Applied Biological Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan.
authors: Nobutaka
authors: N
authors: Kitahata
authors: Tadao
authors: T
authors: Asami
mesh_terms: D000040:Abscisic Acid / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry*; D049308:Dioxygenases / Q000378:metabolism; D018525:Germination; D015394:Molecular Structure; D009281:Naphthalenes / Q000494:pharmacology*; D010937:Plant Growth Regulators / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry; D010940:Plant Proteins / Q000378:metabolism; D011485:Protein Binding; D036226:Seedlings / Q000187:drug effects / Q000254:growth & development; D012639:Seeds / Q000187:drug effects / Q000254:growth & development; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D009281:Naphthalenes; D010937:Plant Growth Regulators; D010940:Plant Proteins; D013449:Sulfonamides; C540973:pyrabactin; D000040:Abscisic Acid; D049308:Dioxygenases; C109043:9-cis-epoxy-carotenoid dioxygenase