title: Periodic incorporation of pendant hydroxyl groups in repeating sequence PLGA copolymers.
abstract: A series of repeating sequence poly(lactic-co-glycolic acid) copolymers (RSC PLGAs) has been prepared with the precise incorporation of a pendant benzyl-ether substituted monomer derived from serine. Copolymers were synthesized from the assembly of sequence-specific, stereopure dimeric, and trimeric segmers of lactic, glycolic, and (S)-3-benzyloxy-2-hydroxypropionic acids with controlled and varied tacticities. Deprotection of the hydroxyl groups was accomplished by catalytic hydrogenolysis to yield highly functionialized, hydrophilic polyesters. The (1)H and (13)C NMR spectra for all of the copolymers were consistent with sequence and stereochemical retention and lacked the signal broadening that is inherent with more random copolymers.
authors: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
authors: Ryan M
authors: RM
authors: Stayshich
authors: Ryan M
authors: RM
authors: Weiss
authors: Jian
authors: J
authors: Li
authors: Tara Y
authors: TY
authors: Meyer
mesh_terms: D006016:Glycolates / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007773:Lactates / Q000138:chemical synthesis*; D019344:Lactic Acid / Q000737:chemistry*; D015394:Molecular Structure; D011091:Polyesters / Q000138:chemical synthesis*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012694:Serine / Q000031:analogs & derivatives; D013237:Stereoisomerism
chemical_list: D006016:Glycolates; D007773:Lactates; D011091:Polyesters; C031149:glycolic acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012694:Serine