title: [Incidence and physiopathology of high-grade dysplasia in Barrett's esophagus].
abstract: Barrett's esophagus is a well-known precursor of esophageal adenocarcinoma. Monitoring patients with Barrett's esophagus is recommended for detecting high-grade dysplasia or cancer. Gastroesophageal reflux disease affects approximately 20% of the population in developed countries. About 10-15% of patients with gastroesophageal reflux disease develop Barrett's esophagus, which can progress to adenocarcinoma. The esophagus is normally lined by squamous mucosa. Therefore, it is clear that for an adenocarcinoma, there is a prior sequence of events that lead to normal squamous mucosa transformation.
authors: Assistance publique-Hôpitaux de Paris, CHU Cochin Port-Royal, service de gastroentérologie, 75014 Paris, France. romain.coriat@cch.aphp.fr
authors: Romain
authors: R
authors: Coriat
authors: Géraldine
authors: G
authors: Perkins
authors: Catherine
authors: C
authors: Brezault
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D001471:Barrett Esophagus / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology*; D002471:Cell Transformation, Neoplastic; D004938:Esophageal Neoplasms / Q000473:pathology; D006801:Humans; D015994:Incidence