title: Preliminary evaluation of gene expression profiles in liver of mice exposed to Taihu Lake drinking water for 90 days.
abstract: Differential gene expression profiling was performed via DNA microarray in the liver tissue of Mus musculus mice after exposure to drinking water of Taihu Lake for 90 days. A total of 75 differentially expressed candidate genes (DEGs) were identified (1.5-fold, p ≤ 0.05), among which the expression of 29 genes was up-regulated and that of 46 genes was down-regulated. Most DEGs were involved in biological process based on gene ontology mapping analysis. The drinking water of Taihu Lake significantly influenced the expression of genes related to cell proliferation, apoptosis, amino acid metabolism, development and immune responses. Long-term exposure to the Taihu drinking water may result in increased carcinogenic risk.
authors: State Key Laboratory of Pollution Control & Resource Reuse and School of the Environment at Nanjing University, Nanjing, 210046, People's Republic of China.
authors: Yan
authors: Y
authors: Zhang
authors: Weixin
authors: W
authors: Li
authors: Rui
authors: R
authors: Zhang
authors: Jie
authors: J
authors: Sun
authors: Bing
authors: B
authors: Wu
authors: Xuxiang
authors: X
authors: Zhang
authors: Shupei
authors: S
authors: Cheng
mesh_terms: D000818:Animals; D002681:China; D005618:Fresh Water / Q000737:chemistry; D015870:Gene Expression / Q000187:drug effects*; D020869:Gene Expression Profiling; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000633:toxicity; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*; D014881:Water Supply / Q000032:analysis*
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D014874:Water Pollutants, Chemical