title: Association of RGS2 variants with panic disorder in a Japanese population.
abstract: Panic disorder (PD) is a severe and chronic psychiatric disorder with significant genetic components underlying its etiology. The gene regulator of G protein signaling 2 (RGS2) has been reported to be associated with anxiety disorders. To confirm the association of RGS2 with PD, we investigated three single nucleotide polymorphisms (SNPs) of RGS2 (rs10801152, rs4606, and rs1819741) in 677 Japanese PD cases and 460 controls. The SNP rs10801152 was suggestive of an association with PD (allele P = 0.045 adjusted using sex and age as confounding factors). The three-SNP haplotype was significantly associated with PD (global permutation P = 4 × 10(-4)). The haplotypes T-G-C and T-C-T showed significant association and protective effect on PD (T-G-C, permutation P = 0.038, OR = 0.80, 95%CI = 0.68-0.95; T-C-T, permutation P = 0.004, OR = 0.38, 95%CI = 0.21-0.70). These results provide support for an association of RGS2 with PD in a Japanese population.
authors: Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298-0126, USA. totowa@vcu.edu
authors: Takeshi
authors: T
authors: Otowa
authors: Takafumi
authors: T
authors: Shimada
authors: Yoshiya
authors: Y
authors: Kawamura
authors: Nagisa
authors: N
authors: Sugaya
authors: Eiji
authors: E
authors: Yoshida
authors: Ken
authors: K
authors: Inoue
authors: Shin
authors: S
authors: Yasuda
authors: Xiaoxi
authors: X
authors: Liu
authors: Takanobu
authors: T
authors: Minato
authors: Mamoru
authors: M
authors: Tochigi
authors: Tadashi
authors: T
authors: Umekage
authors: Kiyoto
authors: K
authors: Kasai
authors: Hisashi
authors: H
authors: Tanii
authors: Yuji
authors: Y
authors: Okazaki
authors: Hisanobu
authors: H
authors: Kaiya
authors: Tsukasa
authors: T
authors: Sasaki
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016584:Panic Disorder / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D020710:RGS Proteins / Q000235:genetics*
chemical_list: D020710:RGS Proteins; C087182:RGS2 protein, human