title: Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma.
abstract: OBJECTIVE
  To describe successful long-term tumor control in metastatic adrenocortical carcinoma, a relatively rare tumor with limited treatment options outside of surgery.
  
  
  METHODS
  We present the clinical, radiologic, and pathologic findings in a patient with failure of or intolerance to conventional treatments for metastatic adrenocortical carcinoma.
  
  
  RESULTS
  A 48-year-old man with adrenocortical carcinoma had disease progression with systemic therapies including mitotane, 5-fluorouracil, streptozotocin, bevacizumab, and external beam radiation therapy. Treatment with all chemotherapeutic drugs was ceased, and he was prescribed mebendazole, 100 mg twice daily, as a single agent. His metastases initially regressed and subsequently remained stable. While receiving mebendazole as a sole treatment for 19 months, his disease remained stable. He did not experience any clinically significant adverse effects, and his quality of life was satisfactory. His disease subsequently progressed after 24 months of mebendazole monotherapy.
  
  
  CONCLUSIONS
  Mebendazole may achieve long-term disease control of metastatic adrenocortical carcinoma. It is well tolerated and the associated adverse effects are minor.
authors: Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
authors: Irina Y
authors: IY
authors: Dobrosotskaya
authors: Gary D
authors: GD
authors: Hammer
authors: David E
authors: DE
authors: Schteingart
authors: Katherine E
authors: KE
authors: Maturen
authors: Francis P
authors: FP
authors: Worden
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018450:Disease Progression; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011859:Radiography; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D008463:Mebendazole