title: Significant elevation and correlation of plasma neutrophil gelatinase associated lipocalin and its complex with matrix metalloproteinase-9 in patients with pelvic inflammatory disease.
abstract: BACKGROUND
  To detect the expression of plasma neutrophil gelatinase associated lipocalin (NGAL) and its complex with matrix metalloproteinase-9 (MMP-9) in patients with pelvic inflammatory disease (PID).
  
  
  METHODS
  Enzyme-linked immunosorbent assay was used to measure the levels of plasma NGAL and NGAL/MMP-9 complex.
  
  
  RESULTS
  The levels of plasma NGAL or NGAL/MMP-9 complex were increased in patients with PID compared with those in normal controls and decreased significantly after treatment. Pre-treatment plasma level of NGAL was significantly correlated with WBC and neutrophil counts. In patients with PID, plasma level of NGAL/MMP-9 complex was correlated with plasma level of NGAL or MMP-9 significantly. In predicting PID, the sensitivities of NGAL and NGAL/MMP-9 complex were 76.6% and 78.1%; the negative predictive values, 72.7% and 74.5%.
  
  
  CONCLUSIONS
  Plasma NGAL and NGAL/MMP-9 complex may act as diagnostic adjuvant biomarkers for PID. In patients with PID, about 80% have plasma levels of NGAL or NGAL/MMP-9 complex level >10.04 ng/ml or 2.33 ng/ml, respectively.
authors: School of Nursing, Chung Shan Medical University, Taiwan.
authors: Hsiu-Ting
authors: HT
authors: Tsai
authors: Pen-Hua
authors: PH
authors: Su
authors: Tsung-Hsien
authors: TH
authors: Lee
authors: Yi-Torng
authors: YT
authors: Tee
authors: Long-Yau
authors: LY
authors: Lin
authors: Shun-Fa
authors: SF
authors: Yang
authors: Po-Hui
authors: PH
authors: Wang
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood* / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000097:blood* / Q000378:metabolism*; D000292:Pelvic Inflammatory Disease / Q000097:blood* / Q000201:enzymology / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000097:blood* / Q000378:metabolism*; D012016:Reference Values
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D020780:Matrix Metalloproteinase 9