title: Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice.
abstract: OBJECTIVE
  To study the anticonvulsant activity and neurotoxicity of ethanolic extract and ethyl acetate fraction of the rhizome of Smilax china (EESC and EAF, respectively) in mice.
  
  
  METHODS
  The anticonvulsant activities of EESC and EAF were studied against maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures in mice and neurotoxicity was determined using rotarod test.
  
  
  RESULTS
  The duration of hindleg extension in MES test was reduced significantly (P < 0.001) by EESC at a dose level of 400 mg/kg and EAF at both higher dose levels (200 and 400 mg/kg). In PTZ model, the seizure latency was prolonged by all the test groups.
  
  
  CONCLUSIONS
  The EESC and EAF may help to control petit mal and grand mal seizures.
authors: Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University, Chennai - 117, Tamil Nadu, India.
authors: A
authors: A
authors: Vijayalakshmi
authors: V
authors: V
authors: Ravichandiran
authors: J
authors: J
authors: Anbu
authors: Malarkodi
authors: M
authors: Velraj
authors: S
authors: S
authors: Jayakumari