title: In vitro evaluation of apoptosis with 99mTc-glucoheptonate.
abstract: Radiopharmaceuticals are useful to evaluate effectiveness of cancer treatments as well as diagnosis of diseases. (99m)Tc-Glucoheptonate has high sensitivity for imaging lung cancer tissues. In this study, the potential use of (99m)Tc-glucoheptonate for monitoring apoptosis related to chemotherapeutic agents is investigated in vitro using A549 lung cancer cell line. A decrease in (99m)Tc-glucoheptonate uptake ratio was observed depending on the level of apoptosis. (99m)Tc-glucoheptonate is found to be useful for the detection of apoptosis following treatment in A549 lung tumor cells.
authors: Ege University, Institute of Nuclear Sciences, Department of Nuclear Applications, Bornova, Izmir, Turkey.
authors: Gamze
authors: G
authors: Kocagozoglu
authors: Fatma Yurt
authors: FY
authors: Lambrecht
authors: Cumhur
authors: C
authors: Gunduz
authors: Musteyde
authors: M
authors: Yucebaş
authors: Elif Bayrak
authors: EB
authors: Tabar
authors: Aykut
authors: A
authors: Ozgur
authors: Tugce
authors: T
authors: Balci
mesh_terms: D017209:Apoptosis; D045744:Cell Line, Tumor; D006801:Humans; D020287:In Situ Nick-End Labeling; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D015609:Organotechnetium Compounds; D013400:Sugar Acids
chemical_list: D015609:Organotechnetium Compounds; D013400:Sugar Acids; C007852:alpha-glucoheptonic acid