title: Concise review: Adipose-derived stromal vascular fraction cells and stem cells: let's not get lost in translation.
abstract: Subcutaneous fat has emerged as an alternative tissue source for stromal/stem cells in regenerative medicine. Over the past decade, international research efforts have established a wealth of basic science and preclinical evidence regarding the differentiation potential and regenerative properties of both freshly processed, heterogeneous stromal vascular fraction cells and culture expanded, relatively homogeneous adipose-derived stromal/stem cells. The stage has been set for clinicians to translate adipose-derived cells from the bench to the bedside; however, this process will involve "development" steps that fall outside of traditional "hypothesis-driven, mechanism-based" paradigm. This concise review examines the next stages of the development process for therapeutic applications of adipose-derived cells and highlights the current state of the art regarding clinical trials. It is recommended that the experiments addressing these issues be reported comprehensively in the peer-review literature. This transparency will accelerate the standardization and reproducibility of adipose-derived cell therapies with respect to their efficacy and safety.
authors: Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA. gimblejm@pbrc.edu
authors: Jeffrey M
authors: JM
authors: Gimble
authors: Bruce A
authors: BA
authors: Bunnell
authors: Ernest S
authors: ES
authors: Chiu
authors: Farshid
authors: F
authors: Guilak
mesh_terms: D050156:Adipogenesis / Q000502:physiology; D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D017154:Stromal Cells / Q000166:cytology*