title: Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition.
abstract: The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol (5), is described. The key step involves a fragment coupling using "click chemistry." The preliminary biological evaluation of triazole-cycloproparadicicol is also reported.
authors: Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, New York 10027.
authors: Xiaoguang
authors: X
authors: Lei
authors: Samuel J
authors: SJ
authors: Danishefsky