title: Oxygenation status of urogenital tumors.
abstract: In malignant urogenital tumors, tissue oxygenation is compromised and very heterogeneous,with steep and fluctuating spatio-temporal oxygen gradients signaling a complex instability in tumor oxygenation (complex "4D-heterogeneity"). Tumor hypoxia is highly dynamic, and rapidly changing pO(2) gradients may be key factors driving hypoxia-dependent adaptive processes leading to malignant progression. The grand median oxygen tension in malignant urogenital tumors is 7-11 mmHg. In contrast, benign leiomyomas of the uterus are severely, but uniformly, hypoxic with only shallow oxygen gradients ("static hypoxia"). In these benign tumors, the median pO(2) is 1 mmHg and signs of hypoxia-driven processes are missing.
authors: Department of Radiooncology and Radiotherapy, University Medical Center, Langenbeckstrasse 1, 55131 Mainz, Germany. vaupel@uni-mainz.de
authors: Peter
authors: P
authors: Vaupel
authors: Michael
authors: M
authors: Hoeckel
authors: Arnulf
authors: A
authors: Mayer
mesh_terms: D019069:Cell Respiration; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D014565:Urogenital Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D010100:Oxygen