title: Hippocampal sclerosis and ipsilateral headache among mesial temporal lobe epilepsy patients.
abstract: OBJECTIVE
  To investigate the frequency and patterns of headache in a well-defined and homogeneous group of mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) patients.
  
  
  METHODS
  One hundred consecutive MTLE-HS patients under comprehensive presurgical evaluation were evaluated from May 2009 to April 2010. A standardized questionnaire was applied according to the criteria of the International Headache Society (IHS). Headache diagnosis was based on the second edition of the International Classification of Headache Disorders (ICHD-II).
  
  
  RESULTS
  Ninety-two patients (92%) had at least one headache episode during the previous 12 months. Migraine occurred in 51.9% of patients and tension-type headache (TTH) in 39.1%. Patients with migraine presented higher frequency (p=0.002) and severity of episodes (p<0.001), as well as lateralized pain (p=0.001) than individuals with TTH. MTLE-HS patients with unilateral HS and predominantly unilateral headache (irrespective of the type), presented pain ipsilateral to the HS (OR 8.5; CI 95%=2.1-35.1; p=0.003).
  
  
  CONCLUSIONS
  Headache is a frequent clinical symptom of lateralizing value, which may share common pathophysiology with epileptogenesis among MTLE-HS patients.
authors: Centro de Epilepsia de Santa Catarina, Hospital Governador Celso Ramos, Florianópolis, SC, Brazil.
authors: Jean Costa
authors: JC
authors: Nunes
authors: Danielle Brandes
authors: DB
authors: Zakon
authors: Lucia Sukys
authors: LS
authors: Claudino
authors: Ricardo
authors: R
authors: Guarnieri
authors: Alexandre
authors: A
authors: Bastos
authors: Luiz Paulo
authors: LP
authors: Queiroz
authors: Roger
authors: R
authors: Walz
authors: Katia
authors: K
authors: Lin
mesh_terms: D000328:Adult; D017668:Age of Onset; D000927:Anticonvulsants / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D004522:Educational Status; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D007839:Functional Laterality; D006261:Headache / Q000209:etiology* / Q000503:physiopathology; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D012598:Sclerosis; D012959:Socioeconomic Factors; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid