title: Evaluation of intellectual development of children following congenital, mildly symptomatic cytomegalovirus (CMV) infection. A prospective study.
abstract: OBJECTIVE
  Assessment of intellectual development of 6-year-old children following asymptomatic or mildly symptomatic congenital cytomegalovirus infection in infancy.
  
  
  METHODS
  A longitudinal, prospective cohort study concerning 38 (2%) children with congenital cytomegalovirus infection confirmed by specific serological and molecular tests, selected from the group of 1895 neonates preliminarily enrolled into the study. The first specialistic clinical assessment was performed during the neonatal and early infancy period, the second at the age of 12-18 months, and the final comprehensive clinical evaluation was carried out at the age of 6-6.5 years.
  
  
  RESULTS
  Psychological evaluation showed normal mental development (Intelligence Quotient ranged from 88 to 114), but 12 (32%) children showed abnormalities in speech development and in 3 (8%) poor visual-motor integration was observed. Emotional and social functioning indicate a normal level of maturity, but 14 (37%) children exhibited increased emotional sensitivity. Psychological assessment indicate that 6 (16%) children may have problems with school maturity.
  
  
  CONCLUSIONS
  Long-term follow-up of children with congenital cytomegalovirus infection is necessary, including those with a mild clinical course, in view of the possible late sequelae, especially concerning intellectual development and hearing impairment.
authors: Department of Infant Diseases, Children's Memorial Health Institute, Warsaw, Poland. b.milewska@czd.pl
authors: Bogumniła
authors: B
authors: Milewska-Bobula
authors: Joanna
authors: J
authors: Zebrowska
authors: Marzena
authors: M
authors: Olszaniecka
authors: Stefania
authors: S
authors: Pijanowska
authors: Marzanna
authors: M
authors: Radziszewska-Konopka
authors: Bozena
authors: B
authors: Lipka
mesh_terms: D015984:Causality; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000453:epidemiology*; D004569:Electroencephalography; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000453:epidemiology*; D006529:Hepatomegaly / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007360:Intelligence; D007361:Intelligence Tests; D007805:Language Development Disorders / Q000175:diagnosis / Q000453:epidemiology*; D008137:Longitudinal Studies; D009123:Muscle Hypotonia / Q000453:epidemiology; D011446:Prospective Studies; D013163:Splenomegaly / Q000175:diagnosis / Q000453:epidemiology