title: Magnetization-prepared IDEAL bSSFP: a flow-independent technique for noncontrast-enhanced peripheral angiography.
abstract: OBJECTIVE
  To propose a new noncontrast-enhanced flow-independent angiography sequence based on balanced steady-state free precession (bSSFP) that produces reliable vessel contrast despite the reduced blood flow in the extremities.
  
  
  METHODS
  The proposed technique addresses a variety of factors that can compromise the exam success including insufficient background suppression, field inhomogeneity, and large volumetric coverage requirements. A bSSFP sequence yields reduced signal from venous blood when long repetition times are used. Complex-sum bSSFP acquisitions decrease the sensitivity to field inhomogeneity but retain phase information, so that data can be processed with the Iterative Decomposition of Water and Fat with Echo Asymmetry and Least-Squares Estimation (IDEAL) method for robust fat suppression. Meanwhile, frequent magnetization preparation coupled with parallel imaging reduces the muscle and long-T(1) fluid signals without compromising scan efficiency.
  
  
  RESULTS
  In vivo flow-independent peripheral angiograms with reliable background suppression and high spatial resolution are produced. Comparisons with phase-sensitive bSSFP angiograms (that yield out-of-phase fat and water signals, and exploit this phase difference to suppress fat) demonstrate enhanced vessel depiction with the proposed technique due to reduced partial-volume effects and improved venous suppression.
  
  
  CONCLUSIONS
  Magnetization-prepared complex-sum bSSFP with IDEAL fat/water separation can create reliable flow-independent angiographic contrast in the lower extremities.
authors: Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA. cukur@berkeley.edu
authors: Tolga
authors: T
authors: Cukur
authors: Ann
authors: A
authors: Shimakawa
authors: Huanzhou
authors: H
authors: Yu
authors: Brian A
authors: BA
authors: Hargreaves
authors: Bob S
authors: BS
authors: Hu
authors: Dwight G
authors: DG
authors: Nishimura
authors: Jean H
authors: JH
authors: Brittain
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000792:Angiography / Q000379:methods*; D001783:Blood Flow Velocity; D001834:Body Water / Q000737:chemistry; D002138:Calibration; D003287:Contrast Media / Q000494:pharmacology; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D016018:Least-Squares Analysis; D018810:Magnetic Resonance Angiography / Q000379:methods; D008280:Magnetics; D015233:Models, Statistical; D012307:Risk Factors
chemical_list: D003287:Contrast Media