title: DOTASQ as a prototype of nature-inspired G-quadruplex ligand.
abstract: DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).
authors: Institut de Chimie Moléculaire, CNRS UMR5260, Université de Bourgogne, Dijon, France.
authors: Loic
authors: L
authors: Stefan
authors: Aurore
authors: A
authors: Guédin
authors: Samir
authors: S
authors: Amrane
authors: Nicole
authors: N
authors: Smith
authors: Franck
authors: F
authors: Denat
authors: Jean-Louis
authors: JL
authors: Mergny
authors: David
authors: D
authors: Monchaud
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis / Q000138:chemical synthesis / Q000378:metabolism*; D001665:Binding Sites; D005583:Fourier Analysis; D054856:G-Quadruplexes; D006147:Guanine / Q000378:metabolism*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008024:Ligands; D047028:Macrocyclic Compounds / Q000032:analysis / Q000138:chemical synthesis / Q000378:metabolism*; D008958:Models, Molecular; D015335:Molecular Probes / Q000032:analysis / Q000138:chemical synthesis / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D013725:Terbium / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D047028:Macrocyclic Compounds; D015335:Molecular Probes; D013725:Terbium; D006147:Guanine