title: Regulation of neural process growth, elaboration and structural plasticity by NF-κB.
abstract: The nuclear factor-kappa B (NF-κB) family of transcription factors has recently emerged as a major regulator of the growth and elaboration of neural processes. NF-κB signaling has been implicated in controlling axon initiation, elongation, guidance and branching and in regulating dendrite arbor size and complexity during development and dendritic spine density in the adult. NF-κB is activated by a variety of extracellular signals, and either promotes or inhibits growth depending on the phosphorylation status of the p65 NF-κB subunit. These novel roles for NF-κB, together with recent evidence implicating NF-κB in the regulation of neurogenesis in the embryo and adult, have important implications for neural development and for learning and memory in the mature nervous system.
authors: Cardiff School of Biosciences, University of Cardiff, Biomedical Sciences Building 3, Cardiff CF10 3AT, UK.
authors: Humberto
authors: H
authors: Gutierrez
authors: Alun M
authors: AM
authors: Davies
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D049229:Dendritic Spines / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D016328:NF-kappa B