title: Endothelial progenitor cells correlate with clinical outcome of traumatic brain injury.
abstract: OBJECTIVE
  Endothelial progenitor cells play an active role in vascular repair and revascularization of tissue damaged by traumatic, inflammatory, and ischemic injures. We correlate the changes in circulating endothelial progenitor cells with the severity of traumatic brain injury. The study is designed to investigate the endothelial progenitor cell mobilization after injury and a potential use of circulating endothelial progenitor cells as a prognostic marker for evaluating trauma severity and clinical outcomes.
  
  
  METHODS
  A prospective cohort study conducted in two neurosurgical intensive care units of Tianjin Medical University General Hospital and Tianjin Huanhu Hospital (Tianjin, China).
  
  
  METHODS
  Patients with traumatic brain injury and age- and gender-matched healthy controls.
  
  
  METHODS
  None.
  
  
  RESULTS
  Changes in the levels of circulating endothelial progenitor cells were monitored for up to 21 days in 84 patients with traumatic brain injury. Results were correlated with the clinical assessment of injury severity as determined by the Glasgow Coma Scale. The level of circulating endothelial progenitor cells was found to be suppressed 24-48 hrs after injury but rapidly increased, reaching the highest at days 5-7 post-trauma. Circulating endothelial progenitor cells in patients with improved Glasgow Coma Scale scores were significantly higher than those with deteriorated conditions and remained persistently low in patients who died of trauma.
  
  
  CONCLUSIONS
  The results suggest that the level of circulating endothelial progenitor cells correlates with the clinical severity and outcome of traumatic brain injury and may offer potential as a prognostic marker for traumatic brain injury. A long-term follow-up of these patients is ongoing.
authors: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute, China.
authors: Li
authors: L
authors: Liu
authors: Huijie
authors: H
authors: Wei
authors: Fanglian
authors: F
authors: Chen
authors: Jinghua
authors: J
authors: Wang
authors: Jing-fei
authors: JF
authors: Dong
authors: Jianning
authors: J
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood* / Q000401:mortality / Q000601:surgery; D002452:Cell Count; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D013234:Stem Cells / Q000378:metabolism*; D015599:Trauma Severity Indices; D055815:Young Adult
chemical_list: D015415:Biomarkers