title: [Morphological analysis of bone dynamics and metabolic bone. Characteristics of bone morphometry and bone geometry in patients with type 2 diabetes].
abstract: Recent meta-analysis and some studies have shown that patients with type 2 diabetes mellitus (T2DM) have an increased risk of fractures despite their elevated bone mineral density, suggesting that poor bone quality deteriorates bone strength in T2DM patients. Bone geometry as well as bone turnover and mineralization are key components of bone quality. Limited studies have indicated that the section area and cortical thickness of diaphyses in T2DM patients are narrower and thinner than those in control subjects and that bone formation as well as mineralization in T2DM group are suppressed as compared to normal subjects. High-resolution peripheral quantitative computed tomography (HR-pQCT) revealed that T2DM patients had higher cortical pore volume in distal radius as compared to control subjects and that bone strength index estimated by finite element analysis was lower than that of control group. These results suggest that these bone quality factors are associated with bone strength in T2DM patients.
authors: Internal Medicine 1, Shimane University Faculty of Medicine.
authors: Masahiro
authors: M
authors: Yamamoto
authors: Toshitsugu
authors: T
authors: Sugimoto
mesh_terms: D016723:Bone Remodeling; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D002113:Calcification, Physiologic; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D010012:Osteogenesis; D014057:Tomography, X-Ray Computed