title: Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery.
abstract: Mesoporous titania nanoparticles (MTNs) with excellent biocompatibility (LC(50)≈ 400 μg mL(-1)) and a large surface area (ca. 237.3 m(2) g(-1)) were synthesized and further functionalized with a phosphate-containing fluorescent molecule (i.e. flavin mononucleotide; FMN) and loaded with an anticancer drug (i.e. Doxorubicin) for successful intracellular bioimaging and drug delivery, respectively, in human breast cancer cells BT-20.
authors: Department of Chemical Engineering, National Taiwan University. No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. kevinwu@ntu.edu.tw
authors: Kevin C-W
authors: KC
authors: Wu
authors: Yusuke
authors: Y
authors: Yamauchi
authors: Chen-Yu
authors: CY
authors: Hong
authors: Ya-Huei
authors: YH
authors: Yang
authors: Yung-He
authors: YH
authors: Liang
authors: Takashi
authors: T
authors: Funatsu
authors: Makoto
authors: M
authors: Tsunoda
mesh_terms: D045744:Cell Line, Tumor / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D005486:Flavin Mononucleotide / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D014025:Titanium / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; C009495:titanium dioxide; D005486:Flavin Mononucleotide; D014025:Titanium