title: Natural nanocontainer for the controlled delivery of glycerol as a moisturizing agent.
abstract: Natural halloysite nanotubes with a 15-nm internal lumen and a 50 nm outer diameter were investigated as a nanocontainer for the loading and extended release of glycerol for cosmetic applications. Cytotoxicity testing of the halloysite was conducted on 3T3 and MCF-7 cells, and the tubules showed no toxic effect on the cells for over 48 h. The capability of halloysite for loading glycerol was higher with the USA halloysite than with the New Zealand's, being approximately 20% and 2.3% by weight, respectively. The total elapsed time for releasing glycerol from the nanotubes exceeded 20 h. To further retard the glycerol release rate, the halloysite samples filled with glycerol were coated with several alternate layers of polyethyleneimine and polyacrylic acid. The release rate remained at the same level, however, probably due to the low molecular weight of the polyelectrolytes and the high solubility of glycerol in water.
authors: Mineral Resources Research Division, Korea Institute of Geoscience and Mineral Resources, Daejeon 305-350, Korea.
authors: Y J
authors: YJ
authors: Suh
authors: D S
authors: DS
authors: Kil
authors: K S
authors: KS
authors: Chung
authors: E
authors: E
authors: Abdullayev
authors: Y M
authors: YM
authors: Lvov
authors: D
authors: D
authors: Mongayt
mesh_terms: D016475:3T3 Cells; D000538:Aluminum Silicates / Q000008:administration & dosage / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D000077215:Clay; D003358:Cosmetics / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D005990:Glycerol / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes / Q000737:chemistry*
chemical_list: D000538:Aluminum Silicates; D001672:Biocompatible Materials; D003358:Cosmetics; D003692:Delayed-Action Preparations; D005990:Glycerol; D000077215:Clay