title: Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease.
abstract: Insufficient insulin secretion and insulin resistance are hallmarks of diabetes. Recent studies indicate that insulin plays an important role in maintaining the glomerular filtration barrier. Mima et al. report that glomeruli of diabetic and obese rats suffer from insulin resistance and altered insulin signaling. Protein kinase C inhibitors are able to overcome insulin resistance, offering new hopes for the treatment of the condition.
authors: Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors: Gene-Yuan
authors: GY
authors: Chang
authors: Ae Seo Deok
authors: AS
authors: Park
authors: Katalin
authors: K
authors: Susztak
mesh_terms: D000818:Animals; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance; D007678:Kidney Glomerulus / Q000503:physiopathology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D051381:Rats; D015398:Signal Transduction
chemical_list: D007328:Insulin; D011493:Protein Kinase C