title: Tuning the adhesion of layer-by-layer films to the physicochemical properties of inner limiting membranes using nanoparticles.
abstract: Retinal trauma is a serious concern for patients undergoing inner limiting membrane (ILM) peeling to correct for various vitreoretinal interface conditions. This mechanical trauma can be prevented by modifying the surface of surgical instruments to increase adhesion to the ILM. To this effect, we have studied the effects of roughness and surface charge on the adhesive properties of ILMs by utilizing layer-by-layer (LbL) films with embedded gold nanoparticles (LbL-AuNP films). LbL films were assembled on atomic force microscopy (AFM) tipless cantilevers. Topographical analysis of these films, with and without nanoparticles, showed that LbL films with nanoparticles had a higher rms roughness compared to films alone or unmodified cantilevers. Nanoparticle-modified LbL films significantly increased the adhesion forces at the cantilever-ILM interface, compared to LbL films without particles. Surprisingly, adsorption of gold nanoparticles onto the AFM cantilevers caused increases in adhesion forces greater than those measured with LbL-AuNP films. These results have important implications for the design of surface modifications for vitreoretinal surgical instruments.
authors: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors: Celimar
authors: C
authors: Valentín-Rodríguez
authors: Yuanzu
authors: Y
authors: He
authors: Sai S
authors: SS
authors: Chodavarapu
authors: Mackenzie
authors: M
authors: Smith
authors: Alexander S
authors: AS
authors: Roach
authors: Nicole R
authors: NR
authors: Lewis
authors: Sonal
authors: S
authors: Vaid
authors: Teresa
authors: T
authors: Lin
authors: Derek E
authors: DE
authors: Lord
authors: Sara M
authors: SM
authors: Green
authors: Tongalp H
authors: TH
authors: Tezel
authors: Albena
authors: A
authors: Ivanisevic
mesh_terms: D000268:Adhesiveness; D000327:Adsorption; D055598:Chemical Phenomena; D005131:Eye Injuries; D006046:Gold / Q000737:chemistry; D008567:Membranes, Artificial; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D018625:Microscopy, Atomic Force; D017655:Silicon Compounds / Q000737:chemistry
chemical_list: D008567:Membranes, Artificial; D017655:Silicon Compounds; D006046:Gold; C032734:silicon nitride