title: Posterior hypoperfusion in Parkinson's disease with and without dementia measured with arterial spin labeling MRI.
abstract: OBJECTIVE
  To determine whether quantitative arterial spin labeling (ASL) can be used to evaluate regional cerebral blood flow in Parkinson's disease with dementia (PDD) and without dementia (PD).
  
  
  METHODS
  Thirty-five PD patients, 11 PDD patients, and 35 normal controls were scanned by using a quantitative ASL method with a 3 Tesla MRI unit. Regional cerebral blood flow was compared in the posterior cortex using region-of-interest analysis.
  
  
  RESULTS
  PD and PDD patients showed lower regional cerebral blood flow in the posterior cortex than normal controls (P = 0.002 and P = 0.001, respectively, analysis of variance with a Bonferroni post hoc test).
  
  
  CONCLUSIONS
  This is the first study to detect hypoperfusion in the posterior cortex in PD and PDD patients using ASL perfusion MRI. Because ASL perfusion MRI is completely noninvasive and can, therefore, safely be used for repeated assessments, this method can be used to monitor treatment effects or disease progression in PD.
authors: Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan. kkamagat@juntendo.ac.jp
authors: Koji
authors: K
authors: Kamagata
authors: Yumiko
authors: Y
authors: Motoi
authors: Masaaki
authors: M
authors: Hori
authors: Michimasa
authors: M
authors: Suzuki
authors: Atsushi
authors: A
authors: Nakanishi
authors: Keigo
authors: K
authors: Shimoji
authors: Shinsuke
authors: S
authors: Kyougoku
authors: Ryohei
authors: R
authors: Kuwatsuru
authors: Keisuke
authors: K
authors: Sasai
authors: Osamu
authors: O
authors: Abe
authors: Yoshikuni
authors: Y
authors: Mizuno
authors: Shigeki
authors: S
authors: Aoki
authors: Nobutaka
authors: N
authors: Hattori
mesh_terms: D000368:Aged; D001158:Arteries / Q000473:pathology*; D001921:Brain / Q000098:blood supply; D002560:Cerebrovascular Circulation; D003704:Dementia / Q000175:diagnosis* / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009462:Neurology / Q000379:methods; D010300:Parkinson Disease / Q000175:diagnosis* / Q000473:pathology*; D013113:Spin Labels
chemical_list: D013113:Spin Labels