title: Comparison of hepatitis B surface antibody decay rates after vaccination between hemodialysis and peritoneal dialysis patients.
abstract: OBJECTIVE
  The available information about maintaining effective immunity after hepatitis B virus (HBV) vaccination in dialysis patients is limited. The aim of this study was to determine whether a difference exists in the persistence of immunity between hemodialysis (HD) and peritoneal dialysis (PD) patients. We compared the decay rate of hepatitis B surface antibody (anti-HBs) titers after HBV vaccination between HD and PD patients.
  
  
  METHODS
  A total of 103 HD and 53 PD patients who were completely vaccinated were enrolled. We examined their anti-HBs titers at the 1st month after vaccination then annually thereafter. Changes in the anti-HBs titers were assessed by comparing annual geometric mean titers (GMTs).
  
  
  RESULTS
  The slopes of the anti-HBs titer decay rates plotted on a logarithmic scale for the HD and PD groups were -23.41 and -31.48, respectively. The decay rate of the PD group was significantly faster than that of the HD group (P=0.0053).
  
  
  CONCLUSIONS
  The decay rate of anti-HBs titers in the PD group was faster than that in the HD group. Hepatitis B vaccination could not offer long-term protection in HD or PD patients. Post-vaccination testing every 6-12 months is necessary and revaccination may be protective in dialysis patients, especially in hyper-endemic areas of hepatitis B infection.
authors: Division of Nephrology and Kidney Institute, Department of Medicine, China Medical University Hospital, Taichung, Taiwan, ROC.
authors: Shih-Yi
authors: SY
authors: Lin
authors: Jiung-Hsiun
authors: JH
authors: Liu
authors: Chung-Chih
authors: CC
authors: Lin
authors: Su-Ming
authors: SM
authors: Wang
authors: Chen-An
authors: CA
authors: Tsai
authors: Che-Yi
authors: CY
authors: Chou
authors: Huey-Liang
authors: HL
authors: Kuo
authors: I-Kuan
authors: IK
authors: Wang
authors: Yao-Lung
authors: YL
authors: Liu
authors: Hsin-Hung
authors: HH
authors: Lin
authors: Chiu-Ching
authors: CC
authors: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D006435:Renal Dialysis
chemical_list: D000418:Albumins; D006454:Hemoglobins; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines