title: A baseline for the multivariate comparison of resting-state networks.
abstract: As the size of functional and structural MRI datasets expands, it becomes increasingly important to establish a baseline from which diagnostic relevance may be determined, a processing strategy that efficiently prepares data for analysis, and a statistical approach that identifies important effects in a manner that is both robust and reproducible. In this paper, we introduce a multivariate analytic approach that optimizes sensitivity and reduces unnecessary testing. We demonstrate the utility of this mega-analytic approach by identifying the effects of age and gender on the resting-state networks (RSNs) of 603 healthy adolescents and adults (mean age: 23.4 years, range: 12-71 years). Data were collected on the same scanner, preprocessed using an automated analysis pipeline based in SPM, and studied using group independent component analysis. RSNs were identified and evaluated in terms of three primary outcome measures: time course spectral power, spatial map intensity, and functional network connectivity. Results revealed robust effects of age on all three outcome measures, largely indicating decreases in network coherence and connectivity with increasing age. Gender effects were of smaller magnitude but suggested stronger intra-network connectivity in females and more inter-network connectivity in males, particularly with regard to sensorimotor networks. These findings, along with the analysis approach and statistical framework described here, provide a useful baseline for future investigations of brain networks in health and disease.
authors: The Mind Research Network Albuquerque, NM, USA.
authors: Elena A
authors: EA
authors: Allen
authors: Erik B
authors: EB
authors: Erhardt
authors: Eswar
authors: E
authors: Damaraju
authors: William
authors: W
authors: Gruner
authors: Judith M
authors: JM
authors: Segall
authors: Rogers F
authors: RF
authors: Silva
authors: Martin
authors: M
authors: Havlicek
authors: Srinivas
authors: S
authors: Rachakonda
authors: Jill
authors: J
authors: Fries
authors: Ravi
authors: R
authors: Kalyanam
authors: Andrew M
authors: AM
authors: Michael
authors: Arvind
authors: A
authors: Caprihan
authors: Jessica A
authors: JA
authors: Turner
authors: Tom
authors: T
authors: Eichele
authors: Steven
authors: S
authors: Adelsheim
authors: Angela D
authors: AD
authors: Bryan
authors: Juan
authors: J
authors: Bustillo
authors: Vincent P
authors: VP
authors: Clark
authors: Sarah W
authors: SW
authors: Feldstein Ewing
authors: Francesca
authors: F
authors: Filbey
authors: Corey C
authors: CC
authors: Ford
authors: Kent
authors: K
authors: Hutchison
authors: Rex E
authors: RE
authors: Jung
authors: Kent A
authors: KA
authors: Kiehl
authors: Piyadasa
authors: P
authors: Kodituwakku
authors: Yuko M
authors: YM
authors: Komesu
authors: Andrew R
authors: AR
authors: Mayer
authors: Godfrey D
authors: GD
authors: Pearlson
authors: John P
authors: JP
authors: Phillips
authors: Joseph R
authors: JR
authors: Sadek
authors: Michael
authors: M
authors: Stevens
authors: Ursina
authors: U
authors: Teuscher
authors: Robert J
authors: RJ
authors: Thoma
authors: Vince D
authors: VD
authors: Calhoun