title: [Relationship of dietary iron intake, body iron overload and the risk of metabolic syndrome].
abstract: OBJECTIVE
  To investigate the relationship among dietary iron intake, body iron overload and risk of metabolic syndrome.
  
  
  METHODS
  87 MS patients and 102 matched healthy adults were recruited. Fasting blood samples were collected and assayed for serum ferritin (SF), serum iron (SI), total iron-binding capacity (TIBC), fasting insulin (FIN), fasting blood glucose (FBG), MDA, SOD and NF-kappaB. The data of dietary intake were collected by using a 24-hour dietary recall method for 7 consecutive days by trained interviewers.
  
  
  RESULTS
  Total dietary iron intake, iron intake from animal source, serum MDA and NF-kappaB in MS group was significantly higher than that in the control group. SF, SI, siderophilin saturation and serum SOD in MS group was lower than that in the control group. There is a positive correlation between serum iron and insulin resistance index and blood glucose. When the total dietary iron intake greater than 15 mg/d was defined as iron over intake, the risk of suffering from MS was high (OR = 7.12) in those subjects with over intake of total iron. When the animal source iron intake greater than 7.5 mg/d was defined as iron over intake, the risk of suffering from MS was high (OR = 7.73) in those subjects with over intake of animal source iron. Fat and iron intake are influencing factors for MS according to Logistic multiple factor regression analysis.
  
  
  CONCLUSIONS
  Iron overload induced by higher meat-based iron intake might be associated with higher risk of MS.
authors: Guangzhou Centre for Disease Control and Prevention, Guangzhou 510080, China. biotin2001@163.com
authors: Xincai
authors: X
authors: Xiao
authors: Jian
authors: J
authors: Liu
authors: Bufan
authors: B
authors: Luo
authors: Xiang
authors: X
authors: Feng
authors: Yixiang
authors: Y
authors: Su
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D019190:Iron Overload / Q000150:complications*; D019266:Iron, Dietary / Q000008:administration & dosage*; D008297:Male; D008460:Meat; D024821:Metabolic Syndrome / Q000209:etiology* / Q000378:metabolism*; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D019266:Iron, Dietary