title: A cascade process for the synthesis of gem-difluoromethylene compounds.
abstract: An efficient strategy for the synthesis of 2,2-difluoro-2,3-dihydrofuran derivatives from β-fluoroalkyl-β-enaminoketones is described. The reaction occurred via an intramolecular halophilic attack-initiated cascade process. A series of 2,3-dihydrofurans were prepared in high yields. And an intermolecular domino process achieved providing polysubstituted furans. The mechanism of the reaction is discussed.
authors: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
authors: Zixian
authors: Z
authors: Chen
authors: Jiangtao
authors: J
authors: Zhu
authors: Haibo
authors: H
authors: Xie
authors: Shan
authors: S
authors: Li
authors: Yongming
authors: Y
authors: Wu
authors: Yuefa
authors: Y
authors: Gong