title: Long-term outcomes after laparoscopic colectomy.
abstract: OBJECTIVE
  To evaluate long-term outcomes in a large series of patients who randomly received laparoscopic or open colorectal resection.
  
  
  METHODS
  From February 2000 to December 2004, six hundred sixty-two patients with colorectal disease were randomly assigned to laparoscopic (LPS, n = 330) or open (n = 332) colorectal resection. All patients were analyzed on an intention-to-treat basis. Long-term follow-up was carried out every 6 mo by office visits. In 526 cancer patients five-year overall and disease-free survival were evaluated. Median oncologic follow-up was 96 mo.
  
  
  RESULTS
  Eight (4.2%) LPS group patients needed conversion to open surgery. Overall long-term morbidity rate was 7.6% (25/330) in the LPS vs 11.1% (37/332) in the open group (P = 0.17). In cancer patients, five-year overall survival was 68.6% in the LPS group and 64.0% in the Open group (P = 0.27). Excluding stage IV patients, five-year local and distant recurrence rates were 32.5% in the LPS group and 36.8% in the Open group (P = 0.36). Further, no difference in recurrence rate was found when patients were stratified according to cancer stage.
  
  
  CONCLUSIONS
  LPS colorectal resection was associated with a slightly lower incidence of long-term complications than open surgery. No difference between groups was found in overall and disease-free survival rates.
authors: Marco Braga, Nicolò Pecorelli, Matteo Frasson, Andrea Vignali, Walter Zuliani, Valerio Di Carlo, Department of Surgery, San Raffaele University, 20132 Milan, Italy.
authors: Marco
authors: M
authors: Braga
authors: Nicolò
authors: N
authors: Pecorelli
authors: Matteo
authors: M
authors: Frasson
authors: Andrea
authors: A
authors: Vignali
authors: Walter
authors: W
authors: Zuliani
authors: Valerio Di
authors: VD
authors: Carlo