title: Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
abstract: BACKGROUND
  There is evidence that myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by activation of immune, inflammatory, oxidative and nitrosative stress (IO&NS) pathways. The present study was carried out in order to examine whether ME/CFS is accompanied by increased levels of plasma peroxides and serum oxidized LDL (oxLDL) antibodies, two biomarkers of oxidative stress.
  
  
  METHODS
  Blood was collected from 56 patients with ME/CFS and 37 normal volunteers. Severity of ME/CFS was measured using the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.
  
  
  RESULTS
  Plasma peroxide concentrations were significantly higher in patients with ME/CFS than in normal controls. There was a trend towards significantly higher serum oxLDL antibodies in ME/CFS than in controls. Both biomarkers contributed significantly in discriminating between patients with ME/CFS and normal controls. Plasma peroxide and serum oxLDL antibody levels were both significantly related to one of the FF symptoms.
  
  
  CONCLUSIONS
  The results show that ME/CFS is characterized by increased oxidative stress.
authors: Maes Clinics@TRIA, Bangkok, Thailand. dr.michaelmaes@hotmail.com
authors: Michael
authors: M
authors: Maes
authors: Marta
authors: M
authors: Kubera
authors: Marc
authors: M
authors: Uytterhoeven
authors: Nicolas
authors: N
authors: Vrydags
authors: Eugene
authors: E
authors: Bosmans
mesh_terms: D000328:Adult; D000906:Antibodies / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015673:Fatigue Syndrome, Chronic / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000276:immunology; D008297:Male; D018384:Oxidative Stress; D010545:Peroxides / Q000097:blood*
chemical_list: D000906:Antibodies; D015415:Biomarkers; D008077:Lipoproteins, LDL; D010545:Peroxides; C099252:oxidized low density lipoprotein