title: Proflavine derivatives as fluorescent imaging agents of amyloid deposits.
abstract: A series of proflavine derivatives for use to further image Aβ amyloid deposits were synthesized and characterized. Aged 3xTg-AD (23 months old) mice hippocampus sections incubated with these derivatives revealed preferential labeling of amyloid plaques. Furthermore an in vitro binding study showed an inhibitory effect, although moderate, of these compounds on Aβ(40) fibril formation. This study highlights the potential of proflavine as a molecular scaffold for designing new Aβ imaging agents, its native fluorescence allowing in vitro neuropathological staining in AD damaged brain sections.
authors: INSERM, Unit U877, J Fourier University, La Tronche, France.
authors: Dominique
authors: D
authors: Garin
authors: Fatima
authors: F
authors: Oukhatar
authors: Andrew B
authors: AB
authors: Mahon
authors: Andrew C
authors: AC
authors: Try
authors: Michel
authors: M
authors: Dubois-Dauphin
authors: Frank M
authors: FM
authors: Laferla
authors: Martine
authors: M
authors: Demeunynck
authors: Marcelle Moulin
authors: MM
authors: Sallanon
authors: Sabine
authors: S
authors: Chierici
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D005456:Fluorescent Dyes / Q000737:chemistry*; D051379:Mice; D008822:Mice, Transgenic; D008856:Microscopy, Fluorescence; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000378:metabolism; D058225:Plaque, Amyloid / Q000473:pathology*; D011370:Proflavine / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D005456:Fluorescent Dyes; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D011370:Proflavine