title: Development of methods for the synthesis of libraries of substituted maleimides and α,β-unsaturated-γ-butyrolactams.
abstract: Synthetic methods for the preparation of maleimide and α,β-unsaturated-γ-butyrolactam compound collections are described. These routes take advantage of Pd cross-coupling and conjugate addition/elimination reactions to permit the facile production of bisaryl-maleimides, anilinoaryl-maleimides, and bisanilino-maleimides while allowing control over the synthesis of symmetrical or nonsymmetrical derivatives. Similarly, the chemistry developed allows for the generation of bisaryl substituted α,β-unsaturated-γ-butyrolactams. The scope and limitations of the approaches are presented.
authors: Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada L8S 4M1.
authors: Emelia
authors: E
authors: Awuah
authors: Alfredo
authors: A
authors: Capretta
mesh_terms: D032701:Biomimetics; D002384:Catalysis; D007769:Lactams / Q000737:chemistry*; D008301:Maleimides / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
chemical_list: D007769:Lactams; D008301:Maleimides; D010165:Palladium