title: The immunopathophysiology of multiple sclerosis.
abstract: This review explores the principle features of the immunopathology of multiple sclerosis (MS), particularly relapsing-remitting MS. It highlights the emerging concepts in the pathogenesis of MS in the context of known features of pathology, including the characterization of cytokine networks promoting inflammatory damage of the central nervous system, B-cell involvement, and inflammatory damage of axons and neurons. This article preferentially focuses on MS rather than animal models of the disease, such as experimental autoimmune encephalomyelitis.
authors: Division of Multiple Sclerosis, Department of Neurology, Washington University, Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA. wug@neuro.wustl.edu
authors: Gregory F
authors: GF
authors: Wu
authors: Enrique
authors: E
authors: Alvarez
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000473:pathology; D001369:Axons / Q000473:pathology; D001921:Brain / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D008214:Lymphocytes / Q000502:physiology; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000473:pathology
chemical_list: D016207:Cytokines