title: Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases.
abstract: Metformin is an oral antidiabetic, which is frequently used in the treatment of type II diabetes mellitus. Serious side effects may be seen during the administration of high doses of metformin. Two cases of lactic acidosis due to ingestion of high dose metformin for suicidal purposes have been presented here; in both cases, clinical improvement was seen with bicarbonate hemodialysis.
authors: Department of Nephrology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey. yaseminsoyoral@yahoo.com
authors: Yasemin Usul
authors: YU
authors: Soyoral
authors: Huseyin
authors: H
authors: Begenik
authors: Habib
authors: H
authors: Emre
authors: Enver
authors: E
authors: Aytemiz
authors: Mustafa
authors: M
authors: Ozturk
authors: Reha
authors: R
authors: Erkoc
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced / Q000378:metabolism / Q000628:therapy*; D000293:Adolescent; D001639:Bicarbonates / Q000008:administration & dosage*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D015314:Dialysis Solutions; D006801:Humans; D007004:Hypoglycemic Agents / Q000633:toxicity*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008687:Metformin / Q000633:toxicity*; D006435:Renal Dialysis / Q000379:methods*; D013406:Suicide, Attempted; D016896:Treatment Outcome
chemical_list: D001639:Bicarbonates; D015314:Dialysis Solutions; D007004:Hypoglycemic Agents; D019344:Lactic Acid; D008687:Metformin