title: [Comprehensive research and evaluation of chlorogenic acid allergy].
abstract: OBJECTIVE
  The non-allergy of chlorogenic acid was demonstrated by the study result of allergy with different purity of chlorogenic acid and comprehensive analysis of literature.
  
  
  METHODS
  The allergies of different samples, which contained the different purity of chlorogenic acid extracts, chlorogenic acid for injection, interior solution of dialysis, external solution of dialysis, post-term chlorogenic acid for injection and chlorogenic acid for injection with degradation, were validated with active systemic anaphylaxis and passive cutaneous anaphylaxis on rats and guinea pigs respectively. The range of molecular weight of macromolecular remains after dialysis were identified by LC-MS.
  
  
  RESULTS
  Allergic reactions were happened in dialysis isolated macromolecular substances, which were identified by LC-MS, and lower purity extracts (purity of chlorogenic acid < or = 40%), while the reactions were not happened in isolated micromolecular substances and high purity samples (purity of chlorogenic acid > or = 92%).
  
  
  CONCLUSIONS
  Macromolecules in lower purity of chlorogenic acid extracts were relative closely to the allergen causing anaphylaxis, but not the chlorogenic acid, which was demonstrated according to the study result and analysis of literatures home and abroad.
authors: West China School of Pharmacy of Sichuan University, Chengdu 610041, China. xiaodon8932@sina.com
authors: Xiaodong
authors: X
authors: Wu
authors: Huarong
authors: H
authors: Yang
authors: Dasheng
authors: D
authors: Lin
authors: Jie
authors: J
authors: Zhang
authors: Fei
authors: F
authors: Luo
authors: Xiaoping
authors: X
authors: Xu
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced; D000818:Animals; D002726:Chlorogenic Acid / Q000009:adverse effects*; D005260:Female; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000209:etiology*; D008297:Male; D008516:Medicine, Chinese Traditional / Q000009:adverse effects; D051381:Rats; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D002726:Chlorogenic Acid