title: Microarrayed recombinant allergens for diagnostic testing.
abstract: The development of protein microarray-based immunoassays and the availability of recombinant allergens have, to a significant extent, emerged together over the past decade. Their long-anticipated wider application to allergy diagnosis has recently begun to accelerate. This review discusses some of the strengths and weaknesses of molecularly defined allergy testing and the microarray platform. Several recent applications of microarray assays to allergy testing are also summarized. Promising findings, particularly in the context of food and latex allergy, point to the potential for greater resolution between clinical reactivity and asymptomatic sensitization with this platform.
authors: Food Allergy Center and Center for Immunology and Inflammatory Diseases at Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. wshreffler@partners.org
authors: Wayne G
authors: WG
authors: Shreffler
mesh_terms: D000485:Allergens; D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis*; D007118:Immunoassay / Q000379:methods*; D046228:Microarray Analysis / Q000379:methods*; D011994:Recombinant Proteins
chemical_list: D000485:Allergens; D011994:Recombinant Proteins