title: Heparin-induced thrombocytopenia and extracorporeal membrane oxygenation: a case report and review of the literature.
abstract: Heparin-induced thrombocytopenia (HIT) is an immune-mediated coagulation side effect of heparin therapy characterized by thrombocytopenia and by a paradoxical prothrombotic state following heparin exposure when thrombotic or thromboembolic events accurse, the condition is classified as Heparin-induced thrombocytopenia with thrombosis (HITT). We report a case of HITT with evidence of small-vessel arterial thrombosis in a 5-day-old newborn receiving extracorporeal membrane oxygenation (ECMO) for congenital diaphragmatic hernia, and our attempt of bivalirudin alternative treatment. We also review previous reports regarding HIT and ECMO with the alternative management in this unique population.
authors: Cardiac Intensive Care Unit, Schneider Children's Medical Center of Israel, Petah Tiqwa, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. uri.pollak@gmail.com
authors: Uri
authors: U
authors: Pollak
authors: Joanne
authors: J
authors: Yacobobich
authors: Hannah
authors: H
authors: Tamary
authors: Ovdi
authors: O
authors: Dagan
authors: Orit
authors: O
authors: Manor-Shulman
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D010976:Platelet Count; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000628:therapy*; D013927:Thrombosis / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D006493:Heparin