title: Cholesterol modulates glycolipid conformation and receptor activity.
abstract: We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.
authors: Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany.
authors: Daniel
authors: D
authors: Lingwood
authors: Beth
authors: B
authors: Binnington
authors: Tomasz
authors: T
authors: Róg
authors: Ilpo
authors: I
authors: Vattulainen
authors: Michal
authors: M
authors: Grzybek
authors: Unal
authors: U
authors: Coskun
authors: Clifford A
authors: CA
authors: Lingwood
authors: Kai
authors: K
authors: Simons
mesh_terms: D002784:Cholesterol / Q000737:chemistry / Q000378:metabolism*; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism; D006017:Glycolipids / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism; D008968:Molecular Conformation; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013079:Sperm Maturation
chemical_list: D006017:Glycolipids; D008081:Liposomes; D011956:Receptors, Cell Surface; C033639:glycolipid receptor; D002784:Cholesterol