title: Systemic sclerosis in a patient with pityriasis rubra pilaris.
abstract: Pityriasis rubra pilaris (PRP) is a rare, chronic erythematous squamous disorder of unknown etiology. It has been found in association with several autoimmune diseases, including thyroiditis, myositis, myasthenia gravis and vitiligo. Herein we report a case of systemic sclerosis in a patient with classic adult pityriasis rubra pilaris. A 38 year old woman with classic adult type 1 pityriasis rubra pilaris (PRP) developed progressive skin thickening of the trunk, face, upper and lower extremities after 2 years of PRP treatment with topical emollients and steroids. Clinical examination and immunological findings were consistent with SSc. Co-existence of these two rare conditions is documented for the first time.
authors: Department of Internal Medicine, Hospital of Hedi Chaker, Sfax, Tunisia.
authors: Faten
authors: F
authors: Frikha
authors: Makram
authors: M
authors: Frigui
authors: Hatem
authors: H
authors: Masmoudi
authors: Hamida
authors: H
authors: Turki
authors: Zouhir
authors: Z
authors: Bahloul
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D017332:Cetirizine / Q000627:therapeutic use; D003078:Colchicine / Q000627:therapeutic use*; D004643:Emollients / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010916:Pityriasis Rubra Pilaris / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D035583:Rare Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D045743:Scleroderma, Diffuse / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D004643:Emollients; D003078:Colchicine; D017332:Cetirizine