title: [Clinical significance of signal transduction and activators of transcription 3, E-cadherin and vimentin in colon cancer].
abstract: OBJECTIVE
  To evaluate the clinical significance of STAT3, E-cadherin and vimentin in colon cancer.
  
  
  METHODS
  Samples of colon cancer tissue and adjacent normal tissue were procured from 70 patients with colon cancer. The expressions of STAT3, E-cadherin and vimentin were detected by immunohistochemistry. Associations of clinicopathological characteristics and these three factors were evaluated.
  
  
  RESULTS
  STAT3, E-cadherin, vimentin were positive in 74.3%,32.9%, and 78.6% in the colon cancer tissues, respectively, and were 15.7%, 82.9%, and 12.9% in normal colon mucosa tissues, respectively. They were correlated with tumor differentiation, depth of invasion, lymph node metastasis, and TNM staging(P<0.05). There was a positive correlation between STAT3 and vimentin expression(P<0.01). However, STAT3 was negatively correlated with E-cadherin(P<0.01).
  
  
  CONCLUSIONS
  STAT3, E-cadherin and vimentin are closely associated with colon cancer. The expressions of STAT3, E-cadherin and vimentin may serve as prognostic indicators for patients with colon cancer.
authors: Department of General Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China. zhangchao5642@163.com
authors: Chao
authors: C
authors: Zhang
authors: Jian-Hua
authors: JH
authors: Xu
authors: Tao
authors: T
authors: Liu
authors: Hao
authors: H
authors: Cui
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D015820:Cadherins / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D014746:Vimentin / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D014746:Vimentin