title: Human clinical trails in antiepileptogenesis.
abstract: Blocking the development of epilepsy (epileptogenesis) is a fundamental research area with the potential to provide large benefits to patients by avoiding the medical and social consequences that occur with epilepsy and lifelong therapy. Human clinical trials attempting to prevent epilepsy (antiepileptogenesis) have been few and universally unsuccessful to date. In this article, we review data about possible pathophysiological mechanisms underlying epileptogenesis, discuss potential interventions, and summarize prior antiepileptogenesis trials. Elements of ideal trials designs for successful antiepileptogenic intervention are suggested.
authors: Department of Neurology, University of Pennsylvania, United States.
authors: Ram
authors: R
authors: Mani
authors: John
authors: J
authors: Pollard
authors: Marc A
authors: MA
authors: Dichter
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D002986:Clinical Trials as Topic / Q000639:trends*; D004827:Epilepsy / Q000503:physiopathology* / Q000517:prevention & control*; D006801:Humans; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants