title: The sphingosine 1-phosphate receptor modulator FTY720 prevents iodide-induced autoimmune thyroiditis in non-obese diabetic mice.
abstract: FTY720 is an immunomodulator that alters migration and homing of lymphocytes via sphingosine 1-phosphate receptors. This compound has been shown to be effective in suppressing autoimmune diseases in experimental and clinical settings. In the present study, we tested whether FTY720 prevented autoimmune thyroiditis in iodide-treated non-obese diabetic (NOD) mice, a model of Hashimoto's thyroiditis (HT) in humans. Mice were given 0.05% iodide water for 8 weeks, and this treatment effectively induced thyroiditis. Iodide-treated mice were injected intraperitoneally with either saline or FTY720 during the iodide treatment. FTY720 clearly suppressed the development of thyroiditis and reduced serum anti-thyroglobulin antibody levels. The number of circulating lymphocytes and spleen cells including CD4(+) T cells, CD8(+) T cells, and CD4(+)Foxp3(+) T cells was decreased in FTY720-treated mice. Our results indicate that FTY720 has immunomodulatory effects on iodide-induced autoimmune thyroiditis in NOD mice and may be a potential candidate for use in the prevention of HT.
authors: Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Kazuki
authors: K
authors: Morohoshi
authors: Michiko
authors: M
authors: Osone
authors: Katsumi
authors: K
authors: Yoshida
authors: Yoshinori
authors: Y
authors: Nakagawa
authors: Saeko
authors: S
authors: Hoshikawa
authors: Hiroshi
authors: H
authors: Ozaki
authors: Yurie
authors: Y
authors: Takahashi
authors: Sadayoshi
authors: S
authors: Ito
authors: Kouki
authors: K
authors: Mori
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D016207:Cytokines / Q000097:blood; D005260:Female; D000068876:Fingolimod Hydrochloride; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors / Q000096:biosynthesis / Q000097:blood; D007454:Iodides; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D011409:Propylene Glycols / Q000627:therapeutic use*; D049349:Receptors, Lysosphingolipid / Q000037:antagonists & inhibitors*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D001323:Autoantibodies; D016207:Cytokines; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D007454:Iodides; D011409:Propylene Glycols; D049349:Receptors, Lysosphingolipid; C006606:anti-thyroglobulin; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine