title: Synthesis and characterization of 3-[131I]iodo-L-tyrosine grafted Fe3O4@SiO2 nanocomposite for single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI).
abstract: In this study, we have successfully developed 3-[131I]iodo-tyrosine grafted Fe3O4@SiO2 nanocomposites for dual potential tumor imaging agent for SPECT and MRI. Fe3O4 nanoparticle was synthesized through thermal decomposition and Fe3O4@SiO2 was prepared by reverse microemulsion method. After conjugating aminopropyltriethoxysiliane, L-tyrosine was introduced by amide coupling reaction. Finally, [131I]iodide was labeled on L-tyrosine grafted Fe3O4@SiO2 nanocomposite by aromatic iodination using chloramine-T.
authors: Molecular Imaging Laboratory, Department of Chemistry, Dongguk University Seoul Campus, Pil-Dong Jung-Gu, Seoul 100-715, Korea.
authors: Seung Il
authors: SI
authors: Park
authors: Bob Jin
authors: BJ
authors: Kwon
authors: Jeong Hoon
authors: JH
authors: Park
authors: Hyun
authors: H
authors: Jung
authors: Kook Hyun
authors: KH
authors: Yu
mesh_terms: D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D007470:Monoiodotyrosine / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology; D033362:Powder Diffraction; D012822:Silicon Dioxide / Q000737:chemistry*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: C523964:3-iodotyrosine; D007457:Iodine Radioisotopes; D058185:Magnetite Nanoparticles; D012822:Silicon Dioxide; D007470:Monoiodotyrosine