title: Cardiac troponin T and creatine kinase predict mid-term infarct size and left ventricular function after acute myocardial infarction: a cardiac MR study.
abstract: OBJECTIVE
  To assess the relation of cardiac troponin T (cTnT) and creatine kinase (CK) release with infarct size and left ventricular function evaluated during the subacute phase as well as four months after acute myocardial infarction (AMI) by contrast-enhanced MRI (CE-MRI).
  
  
  METHODS
  CMR of 80 patients (68 male, mean age 54.2 ± 11.7 years) was performed within 8 days and 4 months after first acute ST-elevation AMI with successful primary angioplasty. CK and cTnT concentrations were determined serially from admission to day 4 after symptom onset.
  
  
  RESULTS
  All single time-points, estimated average release and peak concentrations of CK and cTnT markers correlated significantly with acute and mid-term infarct size (r = 0.43 to 0.79, all P < 0.001), ejection fraction (EF%) (r = -0.42 to -0.58, all P < 0.002) as well as with end-systolic volume (ESV) (r = 0.32 to 0.57, all P < 0.002) at all times of assessment. Patients with cTnT concentrations below the cutoff value of 3.26 μg/L measured 48 h after AMI-related symptom onset had a significant improvement in global (EF: P < 0.0001) myocardial function during the study period, whereas in those with cTnT ≥ 3.26 μg/L, functional recovery did not occur (P = 0.09).
  
  
  CONCLUSIONS
  All single, mean and maximum concentrations of cTnT and CK measured within the first 4 days after AMI permit an accurate prediction of infarct size and left ventricular function as determined in the acute phase as well as four months after AMI by CE-MRI.
authors: University Hospital of Radiology, Innsbruck Medical University, Austria.
authors: Agnes
authors: A
authors: Mayr
authors: Johannes
authors: J
authors: Mair
authors: Gert
authors: G
authors: Klug
authors: Michael
authors: M
authors: Schocke
authors: Kathrin
authors: K
authors: Pedarnig
authors: Thomas
authors: T
authors: Trieb
authors: Otmar
authors: O
authors: Pachinger
authors: Werner
authors: W
authors: Jaschke
authors: Bernhard
authors: B
authors: Metzler
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000494:pharmacology; D003402:Creatine Kinase / Q000378:metabolism*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011237:Predictive Value of Tests; D012372:ROC Curve; D013997:Time Factors; D020107:Troponin T / Q000378:metabolism*
chemical_list: D003287:Contrast Media; D020107:Troponin T; D003402:Creatine Kinase