title: Identification of neural targets for the treatment of psychiatric disorders: the role of functional neuroimaging.
abstract: Neurosurgical treatment of psychiatric disorders has been influenced by evolving neurobiological models of symptom generation. The advent of functional neuroimaging and advances in the neurosciences have revolutionized understanding of the functional neuroanatomy of psychiatric disorders. This article reviews neuroimaging studies of depression from the last 3 decades and describes an emerging neurocircuitry model of mood disorders, focusing on critical circuits of cognition and emotion, particularly those networks involved in the regulation of evaluative, expressive and experiential aspects of emotion. The relevance of this model for neurotherapeutics is discussed, as well as the role of functional neuroimaging of psychiatric disorders.
authors: Department of Psychiatry, Functional Neuroimaging Laboratory, Brigham & Womens Hospital/Harvard Medical School, 824 Boylston Street, Chestnut Hill, MA 02143, USA. vago.dave@gmail.com
authors: David R
authors: DR
authors: Vago
authors: Jane
authors: J
authors: Epstein
authors: Eva
authors: E
authors: Catenaccio
authors: Emily
authors: E
authors: Stern
mesh_terms: D001923:Brain Chemistry; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D006801:Humans; D001523:Mental Disorders / Q000266:history / Q000601:surgery*; D008959:Models, Neurological; D009415:Nerve Net / Q000033:anatomy & histology / Q000601:surgery; D009420:Nervous System / Q000033:anatomy & histology; D009462:Neurology / Q000266:history; D058027:Neuropsychiatry / Q000266:history; D009493:Neurosurgery / Q000266:history / Q000639:trends*; D019635:Neurosurgical Procedures; D010792:Phrenology; D011612:Psychosurgery / Q000266:history / Q000639:trends*