title: (99m)Tc-DMSA absolute and relative renal uptake in cats: procedure and normal values.
abstract: In this study we investigated the influence of technical factors (positioning, background (BG) correction and attenuation correction) on qualitative and quantitative (absolute (AU) and relative (RU) uptake) assessment of feline kidneys with (99m)technetium labelled dimercaptosuccinic acid ((99m)Tc-DMSA). Eleven healthy adult cats were included. Influence of BG and depth correction on quantitative assessment was evaluated. Depth correction was based on the geometric mean method (using dorsal and ventral images) and the use of two standards placed over each individual kidney. Visual evaluation showed superiority of dorsal and ventral over lateral positioning due to increased separation of the kidneys permitting region of interest (ROI) placement without overlap. No apparent influence of BG correction was found for RU. However, AU was systematically overestimated without BG correction. Depth correction did not seem to affect RU in most cases, however, in some cats the differences were not negligible. The values for AU without depth correction were lower compared to depth corrected values.
authors: Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. E.Vandermeulen@Ugent.be
authors: Eva
authors: E
authors: Vandermeulen
authors: Hamphrey R
authors: HR
authors: Ham
authors: André A
authors: AA
authors: Dobbeleir
authors: Carlos
authors: C
authors: De Sadeleer
authors: Amy
authors: A
authors: Piepsz
authors: Tim
authors: T
authors: Waelbers
authors: Simon T
authors: ST
authors: Vermeire
authors: Guido
authors: G
authors: Slegers
authors: Kathelijne Y
authors: KY
authors: Peremans
mesh_terms: D000818:Animals; D002415:Cats; D005260:Female; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism*; D007677:Kidney Function Tests / Q000379:methods / Q000662:veterinary*; D008297:Male; D056888:Patient Positioning / Q000662:veterinary; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012016:Reference Values; D015203:Reproducibility of Results; D019783:Technetium Tc 99m Dimercaptosuccinic Acid / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid