title: Prevalence of gastric and duodenal polyps and risk factors for duodenal neoplasm in korean patients with familial adenomatous polyposis.
abstract: OBJECTIVE
  The prevalence of gastric polyps, duodenal adenoma and duodenal cancer has been reported as being high among familial adenomatous polyposis (FAP) patients, but there have been no reports of this association in Korea. This study evaluated the prevalence of gastric and duodenal polyps and risk factors for duodenal neoplasm in FAP patients in Korea.
  
  
  METHODS
  We reviewed both initial and follow-up endoscopic results from FAP patients. We also investigated the treatment modality of duodenal adenomas and analyzed the risk factors of duodenal neoplasms by logistic regression analysis.
  
  
  RESULTS
  A total of 148 patients with FAP underwent esophagogastroduodenoscopy (EGD), and the fi ndings were as follows: gastric polyp 39.9% (fundic gland polyp 25.7% and gastric adenoma 14.2%), duodenal adenoma 15.5%, gastric cancer 2.7%, and duodenal cancer 0.7%. There were two cases of gastric cancer that developed from benign gastric polyps. There were progressions of duodenal adenomatosis during follow-up, and some degree of relapse occurred after endoscopic resection. Patients with gastric polyps showed a correlation with the occurrence of duodenal neoplasm (odds ratio, 2.814; p=0.024).
  
  
  CONCLUSIONS
  In Korean FAP patients, gastric cancer was detected more frequently, but fundic gland polyps, duodenal adenoma and duodenal cancer were detected less frequently than in Western patients. FAP patients with gastric polyps should undergo regular EGD, particularly for the early detection of duodenal neoplasia.
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: So Youn
authors: SY
authors: Park
authors: Ji Kon
authors: JK
authors: Ryu
authors: Ju Hee
authors: JH
authors: Park
authors: Hyuk
authors: H
authors: Yoon
authors: Ji Yeon
authors: JY
authors: Kim
authors: Yong Bum
authors: YB
authors: Yoon
authors: Jae-Gahb
authors: JG
authors: Park
authors: Sang Hyub
authors: SH
authors: Lee
authors: Sung-Bum
authors: SB
authors: Kang
authors: Ji Won
authors: JW
authors: Park
authors: Jae Hwan
authors: JH
authors: Oh