title: Insecticidal cyclodepsipeptides from Beauveria felina.
abstract: A novel cyclodepsipeptide, iso-isariin B (1), and the known isaridin E (2) were isolated from the entomopathogenic fungus Beauveria felina. Their structures were elucidated using MS/MS fragmentation and extensive 2D-heteronuclear NMR. The X-ray structure of isaridin E was obtained, showing two potent intramolecular H bonds and a type-VI turn with the HyLeu(1)-Pro(2) amide bond in a cis conformation. Iso-isariin B (1) was active against the pest-insect Sitophilus spp. with an LD(50) value of 10 μg/mL. This observation also gives some clues for ecological interpretation of cyclodepsipeptide production by B. felina.
authors: Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 CNRS/MNHN, Muséum National d'Histoire Naturelle, 57 Rue Cuvier (CP 54) 75005 Paris, France.
authors: Aude
authors: A
authors: Langenfeld
authors: Alain
authors: A
authors: Blond
authors: Sabelle
authors: S
authors: Gueye
authors: Patrick
authors: P
authors: Herson
authors: Bastien
authors: B
authors: Nay
authors: Joëlle
authors: J
authors: Dupont
authors: Soizic
authors: S
authors: Prado
mesh_terms: D000818:Animals; D052982:Beauveria / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D048889:Weevils / Q000187:drug effects*
chemical_list: D047630:Depsipeptides; D007306:Insecticides; D010455:Peptides; C559184:iso-isariin B; C032954:isariin