title: Impact of reciprocal translocation t (18; 21) on male infertility and embryo development: lessons from an oocyte-donating ICSI cycle.
abstract: OBJECTIVE
  To report the outcome of intracytoplasmic sperm injection (ICSI) cycles of an oligozoospermic man with reciprocal translocation.
  
  
  METHODS
  Two ICSI cycles were given to a 29-year-old man with severe oligozoospermia and reciprocal translocation t(18;21)(p11;q21) and his wife. In the first cycle, no sperm were found in his semen and all 15 oocytes retrieved were donated to another infertile couple suffering from oligozoospermia and premature ovarian failure. In the second cycle, sperm from the husband's ejaculate were used to fertilize 13 retrieved oocytes.
  
  
  RESULTS
  Eleven embryos were acquired and a healthy girl was born in the oocyte-donated ICSI cycle. In the second cycle, 6 embryos were acquired and only biochemical pregnancy was achieved after three times of embryo transfer.
  
  
  CONCLUSIONS
  By the unusual oocyte-donating ICSI procedures, impact of the new reported reciprocal translocation t (18; 21) (p11; q21) on male fertility and embryo development was suggested.
authors: Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors: Longjie
authors: L
authors: Gu
authors: Hanwang
authors: H
authors: Zhang
authors: Guijin
authors: G
authors: Zhu
mesh_terms: D000328:Adult; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D004624:Embryo Transfer; D047108:Embryonic Development; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007248:Infertility, Male / Q000235:genetics* / Q000628:therapy*; D008297:Male; D009845:Oligospermia / Q000473:pathology / Q000628:therapy*; D018587:Oocyte Donation; D009865:Oocytes / Q000166:cytology; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000473:pathology; D014178:Translocation, Genetic