title: The immune reconstitution after an allogeneic stem cell transplant correlates with the risk of graft-versus-host disease and cytomegalovirus infection.
abstract: Aim of the study was to correlate the clinical outcome of eighteen patients who have undergone an allogeneic stem cell transplant (SCT) with the concentration in the peripheral blood (PB) of lymphocyte subpopulations evaluated at 1 year from transplant. The occurrence of acute GVHD and CMV infection correlated with the concentration of Tregs in the PB; CMV infection also correlated with the content of NK cells. The obtained results document that the concentration of Tregs in the PB after an allogeneic SCT may protect from GVHD and from CMV infection; the potential anti-viral role of NK cells is confirmed.
authors: Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy. torelli@bce.uniroma1.it
authors: Giovanni F
authors: GF
authors: Torelli
authors: Barbarella
authors: B
authors: Lucarelli
authors: Anna P
authors: AP
authors: Iori
authors: Maria S
authors: MS
authors: De Propris
authors: Angela
authors: A
authors: Capobianchi
authors: Walter
authors: W
authors: Barberi
authors: Veronica
authors: V
authors: Valle
authors: Emilia
authors: E
authors: Iannella
authors: Fiammetta
authors: F
authors: Natalino
authors: Caterina
authors: C
authors: Mercanti
authors: Salvatore
authors: S
authors: Perrone
authors: Giuseppe
authors: G
authors: Gentile
authors: Anna
authors: A
authors: Guarini
authors: Robin
authors: R
authors: Foà
mesh_terms: D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D007938:Leukemia / Q000150:complications / Q000276:immunology* / Q000628:therapy; D008223:Lymphoma / Q000150:complications / Q000276:immunology* / Q000628:therapy; D008297:Male; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D015996:Survival Rate; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014184:Transplantation, Homologous; D016896:Treatment Outcome