title: Synthesis and complete assignment of the 1H and 13C NMR spectra of 6-substituted and 2,6-disubstituted pyridazin-3(2H)-ones.
abstract: Several pyridazin-3(2H)-one derivatives were synthesized starting from alkyl furans using oxidation with singlet oxygen to give 4-methoxy or 4-hydroxybutenolides, key intermediates of the synthetic strategy followed. For all pyridazinones reported, a complete assignment of the (1)H and (13)C NMR spectra using one- and two-dimensional NMR spectroscopic methods, which included NOE, DEPT, COSY, HSQC and HMBC experiments, was accomplished. Correlations between the chemical shifts of the heterocyclic ring atoms and substituents at N-2 and C-6 were analyzed.
authors: Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain. pbes@uvigo.es
authors: Pedro
authors: P
authors: Besada
authors: Tamara
authors: T
authors: Costas
authors: Noemi
authors: N
authors: Vila
authors: Carla
authors: C
authors: Chessa
authors: Carmen
authors: C
authors: Terán