title: Fused heterocyclic amido compounds as anti-hepatitis C virus agents.
abstract: We identified a fused heteroaromatic amido structure based on the phenanthridine skeleton as a superior scaffold for candidate drugs with potent anti-HCV activity. Among the compounds synthesized, a phenanthridine analogue with a 1,3-dioxolyl group (24) possessed the most potent anti-HCV activity (EC(50) value: 50 nM), with acceptable cytotoxicity. The structural development and structure-activity relationships of these compounds are described.
authors: Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan. aoyama@iam.u-tokyo.ac.jp
authors: Hiroshi
authors: H
authors: Aoyama
authors: Kazuyuki
authors: K
authors: Sugita
authors: Masahiko
authors: M
authors: Nakamura
authors: Atsushi
authors: A
authors: Aoyama
authors: Mohammed T A
authors: MT
authors: Salim
authors: Mika
authors: M
authors: Okamoto
authors: Masanori
authors: M
authors: Baba
authors: Yuichi
authors: Y
authors: Hashimoto
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D006571:Heterocyclic Compounds; D010617:Phenanthridines