title: Leuprolide acetate 1-month depot for central precocious puberty: hormonal suppression and recovery.
abstract: Methods. This prospective US multicenter trial of leuprolide acetate 1-month depot (7.5-15 mg) for central precocious puberty utilized an open-label treatment period, long-term follow-up, and adult callback. Forty-nine females <9 years old with Tanner breast stage ≥2 before 8 years and 6 males <10 years old with Tanner genital stage ≥2 before 9 years with stimulated LH ≥10 IU/L and bone age advance ≥1 year were enrolled. Results. Subjects were treated for 3.9 ± 2.0 years. Mean peak GnRH-stimulated LH and FSH were prepubertal after the first dose and remained suppressed throughout treatment. During treatment, mean estradiol decreased to the limit of detection and mean testosterone decreased but remained above prepubertal norms. During posttreatment follow-up (3.5 ± 2.2 years), all patients achieved a pubertal hormonal response within 1 year and menses were reported in all females ≥12 years old. No impairment of reproductive function was observed at adulthood (mean age: 24.8 years).
authors: Division of Pediatric Endocrinology and Diabetes, Stanford University Medical Center, Room G313, Stanford, CA 94305-5208, USA.
authors: E Kirk
authors: EK
authors: Neely
authors: Peter A
authors: PA
authors: Lee
authors: Clifford A
authors: CA
authors: Bloch
authors: Lois
authors: L
authors: Larsen
authors: Di
authors: D
authors: Yang
authors: Cynthia
authors: C
authors: Mattia-Goldberg
authors: Kristof
authors: K
authors: Chwalisz