title: Complex decisions in managing HIV infection during pregnancy.
abstract: Both the World Health Organization and the United States Department of Health and Human Services have recently substantially revised perinatal HIV treatment guidelines based on emerging data, much of it from the developing world. Management of HIV infection in pregnancy and delivery is complicated by concerns for maternal and fetal drug toxicity, acquisition of antiretroviral resistance, prior therapy, co-infections with other viruses, as well as incident opportunistic infections. Intrapartum and peripartum obstetric management, including the role of Caesarean section, continue to evolve in the setting of maternal HIV infection. Finally, new data have expanded the role of antiviral therapy in allowing safer infant feeding choices for HIV-infected mothers in resource-limited settings.
authors: Division of Infectious Diseases, Department of Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital, Center for Special Studies-Rogers Unit, 119 W 24th Street, New York, NY 10011, USA. mav9046@med.cornell.edu
authors: Mary A
authors: MA
authors: Vogler
authors: Harjot
authors: H
authors: Singh
authors: Rodney
authors: R
authors: Wright
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*
chemical_list: D019380:Anti-HIV Agents