title: Oropharyngeal squamous cell carcinoma and human papillomavirus-associated cancers in women: epidemiologic evaluation of association.
abstract: OBJECTIVE
  Human papillomavirus (HPV) is a well-established etiologic factor in oropharyngeal squamous cell carcinoma (OPSCC). The objective of this study was to evaluate the association between OPSCC and HPV-related cancerous lesions of the cervix.
  
  
  METHODS
  Demographic, survival, and pathologic data on all female patients diagnosed with OPSCC in Alberta between 1998 and 2008 were collected. A review of pathology reports in these patients was undertaken to identify HPV-related cancerous lesions of the cervix. Standardized incidence ratios (SIRs) of cervical cancer in oropharyngeal cancer patients were calculated using control data obtained from provincial cancer surveillance. Overall and disease-specific survival of patients with OPSCC only versus patients with OPSCC and cervical cancer was calculated using Kaplan-Meier and Cox regression models.
  
  
  RESULTS
  Our results show a significantly elevated overall incidence of cervical cancer in women with OPSCC in comparison to the control population (SIR 29.4, 95% CI 12.05-74.98). Patients with OPSCC and cervical cancer also had a significantly improved disease-specific survival in comparison to patients with no history of cervical cancer.
  
  
  CONCLUSIONS
  Women with OPSCC have a significantly elevated risk of developing HPV-related genital cancers, which suggests frequent HPV coinfection of oropharyngeal and genital tissues in this patient population. Women with OPSCC with cervical cancer also have an improved disease-specific survival, as previously shown with HPV-associated OPSCC.
authors: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alberta, Edmonton, AB.
authors: Vincent L
authors: VL
authors: Biron
authors: David W J
authors: DW
authors: Côté
authors: Hadi
authors: H
authors: Seikaly
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000416:Alberta / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology