title: Health-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis.
abstract: OBJECTIVE
  Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) can present with a broad spectrum of signs and symptoms. The relative effects of different manifestations on health-related quality of life (HRQOL) are unknown.
  
  
  METHODS
  We conducted an individual patient data meta-analysis of baseline Short Form 36 (SF-36) scores from 4 randomized controlled trials of patients with newly diagnosed AAV. We determined the associations between organ manifestations at trial entry and the SF-36 physical composite score (PCS) and mental composite score (MCS) using mixed-effects models adjusted for demographic factors. Associations with each of the 8 domains of the SF-36 were further explored using multivariate multiple regression.
  
  
  RESULTS
  SF-36 data were available from 346 patients. Older age (-0.11 points/year [95% confidence interval (95% CI) -0.21, -0.012]; P = 0.029) and neurologic involvement (-5.84 points; P < 0.001) at baseline were associated with lower PCS. Physical functioning scores were the most affected and older age scores (-0.25 points/year [95% CI -0.38, -0.11]; P < 0.001) and neurologic involvement (-8.48 points [95% CI -12.90, -4.06]; P < 0.001) had the largest effects. The MCS was negatively affected only by chest involvement (P = 0.027), but this effect was not exerted in any particular domain.
  
  
  CONCLUSIONS
  In patients with newly diagnosed AAV, HRQOL is complex and incompletely explained by their organ system manifestations.
authors: McMaster University, Hamilton, Ontario, Canada. mwwalsh@ucalgary.ca
authors: Michael
authors: M
authors: Walsh
authors: Chetan
authors: C
authors: Mukhtyar
authors: Alfred
authors: A
authors: Mahr
authors: Karen
authors: K
authors: Herlyn
authors: Raashid
authors: R
authors: Luqmani
authors: Peter A
authors: PA
authors: Merkel
authors: David R W
authors: DR
authors: Jayne
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000175:diagnosis / Q000523:psychology*; D019268:Antibodies, Antineutrophil Cytoplasmic; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D057566:Self Report; D011795:Surveys and Questionnaires
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic