title: Molecular epidemiological analysis of env and pol sequences in newly diagnosed HIV type 1-infected, untreated patients in Hungary.
abstract: The aim of our study was to monitor the diversity of HIV-1 strains circulating in Hungary and investigate the prevalence of resistance-associated mutations to reverse transcriptase (RT) and protease (PR) inhibitors in newly diagnosed, drug-naive patients. A total of 30 HIV-1-infected patients without prior antiretroviral treatment diagnosed during the period 2008-2010 were included into this study. Viral subtypes and the presence of RT, PR resistance-associated mutations were established by sequencing. Classification of HIV-1 strains showed that 29 (96.6%) patients were infected with subtype B viruses and one patient (3.3%) with subtype A virus. The prevalence of HIV-1 strains with transmitted drug resistance mutations in newly diagnosed individuals was 16.6% (5/30). This study showed that HIV-1 subtype B is still highly predominant in Hungary and documented a relatively high transmission rate of drug resistance in our country.
authors: National Center for Epidemiology, Microbiological Research Group, Budapest, Hungary. marcsim3@microbi.hu
authors: Mária
authors: M
authors: Mezei
authors: Eva
authors: E
authors: Ay
authors: Anita
authors: A
authors: Koroknai
authors: Renáta
authors: R
authors: Tóth
authors: Andrea
authors: A
authors: Balázs
authors: Agnes
authors: A
authors: Bakos
authors: Zoltán
authors: Z
authors: Gyori
authors: Ferenc
authors: F
authors: Bánáti
authors: Márta
authors: M
authors: Marschalkó
authors: Sarolta
authors: S
authors: Kárpáti
authors: János
authors: J
authors: Minárovits
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015752:Genes, env / Q000235:genetics*; D015751:Genes, pol / Q000235:genetics*; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D016333:HIV Protease / Q000235:genetics*; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D009154:Mutation; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D054303:HIV Reverse Transcriptase; D016333:HIV Protease