title: Serotonin transporter gene polymorphism in Chinese patients with poststroke depression: a case-control study.
abstract: OBJECTIVE
  We sought to compare the distribution of the serotonin transporter gene SLC6A4 polymorphism between depressed and nondepressed poststroke patients.
  
  
  METHODS
  Patients with cerebral stroke admitted to hospital during a 1-year period were enrolled in a 1:1 case-control study. All cases and controls were genotyped for polymorphism of the serotonin transporter-linked promoter region and the single-nucleotide polymorphism rs25531.
  
  
  RESULTS
  Among 367 patients with cerebral stroke, 57 (15.5%) were diagnosed with poststroke depression at 1 month after stroke. In the patients with poststroke depression, 7 genotypes of the serotonin transporter gene SLC6A4 were detected, and the frequency of S/S homozygotes was significantly higher (P=0.049) than that in controls.
  
  
  CONCLUSIONS
  S/S homozygosity may be positively associated with the occurrence of poststroke depression in Chinese patients.
authors: Department of Neurology, Ruijin Hospital, School of Public Health, Shanghai Jiao Tong University, 227 South ChongQing Road, Shanghai 200025, China.
authors: Jing
authors: J
authors: Fang
authors: Weihong
authors: W
authors: Yan
authors: Guo-Xin
authors: GX
authors: Jiang
authors: Wei
authors: W
authors: Li
authors: Qi
authors: Q
authors: Cheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003863:Depression / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D020521:Stroke / Q000453:epidemiology / Q000208:ethnology* / Q000523:psychology*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins