title: Acute management in very old patients: is thrombolysis safe?
abstract: In our analysis, patients who were treated with intravenous rt-PA had a better outcome than untreated patients, and this effect was not dependent on age. The weight of evidence to date indicates a potential for benefit in older people, and there is no a priori reason to suspect a diminished effect when compared with younger people. The risk of bleeding is similar in both groups. We believe that clinical treatment guidelines should be revised in order to remove the age restriction in the use of intravenous rt-PA acute ischemic stroke.
authors: Neurology Department, Protege-ACV Program, Hospital Italiano de Buenos Aires, Argentina. maria.zurru@hospitalitaliano.org.ar
authors: Fabiana
authors: F
authors: Ortega
authors: María C
authors: MC
authors: Zurrú
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D019468:Disease Management; D006801:Humans; D017410:Practice Guidelines as Topic; D011379:Prognosis; D011994:Recombinant Proteins / Q000627:therapeutic use; D020521:Stroke / Q000188:drug therapy / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects* / Q000379:methods* / Q000592:standards; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator