title: Enterovirus 71 meningoencephalitis complicating rituximab therapy.
abstract: We describe a fatal case of proven enterovirus 71 meningoencephalitis complicating monoclonal anti-CD20 antibody therapy for non-Hodgkin's lymphoma. B-cell depletion, an effective treatment strategy in an expanding spectrum of hematological and inflammatory disorders, impairs neutralising antibody-mediated clearance of enterovirus. The global threat of emerging neurotropic viruses such as enterovirus 71 is heightened by an increasing pool of susceptible individuals in non-endemic regions.
authors: Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.
authors: Rebekah
authors: R
authors: Ahmed
authors: Michael
authors: M
authors: Buckland
authors: Leo
authors: L
authors: Davies
authors: G Michael
authors: GM
authors: Halmagyi
authors: Shannon L
authors: SL
authors: Rogers
authors: Steven
authors: S
authors: Oberste
authors: Michael H
authors: MH
authors: Barnett
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects; D029821:Enterovirus A, Human / Q000276:immunology*; D004769:Enterovirus Infections / Q000150:complications / Q000276:immunology*; D017809:Fatal Outcome; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008590:Meningoencephalitis / Q000503:physiopathology / Q000821:virology*; D008875:Middle Aged; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D000069283:Rituximab