title: [Human mesenchymal stem cell biology].
abstract: This brief overview summarises the main characteristics of bone marrow mesenchymal stem cells and of adipose-derived stem cells: methods of obtention, phenotype, differentiation potential, hematopoiesis-supportive (stromal) capacity, and immunosuppressive properties. Two points are discussed in detail: 1) criteria for stemness: multipotency, self-renewal, plasticity, and 2) the repair mechanisms implicated in the different indications of cell therapy using these cells: reconstitution of the tissue functional compartment by repopulation consequent to proliferation and differentiation or reprogrammation, stromal effects by secretion of angiogenic, anti-apoptotic, anti-fibrogenic factors, molecules involved in the regulation of inflammation, etc.
authors: Inserm U972, bâtiment Gregory Pincus, hôpital de Bicêtre, 80, avenue du Général Leclerc, 94276 Le Kremlin Bicêtre Cedex, France. pierre.charbord@inserm.fr
authors: Pierre
authors: P
authors: Charbord
authors: Louis
authors: L
authors: Casteilla
mesh_terms: D001854:Bone Marrow Cells; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D039902:Multipotent Stem Cells; D012038:Regeneration