title: Cholesterol-lowering effect of non-viscous soluble dietary fiber Nutriose6 in moderately hypercholesterolemic hamsters.
abstract: NUTRIOSE6 is a new wheat starch-based low-digestible carbohydrate. This study investigated the effect of this soluble non-viscous fiber on cholesterol metabolism. Hamsters fed with 0.25% cholesterol-enriched diet (CHO) were given graded amounts of NUTRIOSE6, i.e., 0% (cellulose, CHO), 3% (N3), 6% (N6) or 9% (N9) (w:w). As compared to CHO diet, 9% NUTRIOSE6 significantly lowered plasma and LDL cholesterol by 14.5 and 23.8%, respectively. The LDL-cholesterol lowering effect was also significant with the 6% dose (-21.4%). NUTRIOSE6 diets prevented hepatic cholesterol accumulation (-10 to -20%) and significantly decreased bile cholesterol (-47 to -68%) and phospholipids (-30 to -45%) concentrations. The 9% NUTRIOSE6 diet significantly decreased the rate of dietary cholesterol absorption (-25%) and markedly stimulated faecal neutral sterol (+81%) and bile salts (+220%) excretion. No significant change in cholesterol 7-alpha-hydroxylase or LDL-receptor activities was observed whereas 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity was reduced by 29%. Reduced cholesterol and bile salt absorptions and lowered cholesterol synthesis are likely mechanisms underlying the cholesterol lowering effect of NUTRIOSE6. Results suggest the use of NUTRIOSE6 as a new dietary cholesterol-lowering agent that should be tested in humans as treatment and evenly prevention of mild hypercholesterolemia.
authors: Avantage Nutrition, 116 chemin des Sables Jaunes, F-13012 Marseille, France. christine.juhel@avantagenutrition.com
authors: Christine
authors: C
authors: Juhel
authors: Fredéric
authors: F
authors: Tosini
authors: Marlène
authors: M
authors: Steib
authors: Daniel
authors: D
authors: Wils
authors: Laetitia
authors: L
authors: Guerin-Deremaux
authors: Denis
authors: D
authors: Lairon
authors: Louis
authors: L
authors: Cara
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000378:metabolism; D006224:Cricetinae; D004043:Dietary Fiber / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D012995:Solubility; D014908:Triticum; D014783:Viscosity
chemical_list: D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D004043:Dietary Fiber; D002784:Cholesterol