title: Anastrozole-related acute hepatitis with autoimmune features: a case report.
abstract: BACKGROUND
  Two cases of acute hepatitis occurring during treatment with anastrozole have previously been reported, but the underlying mechanisms of liver injury are still uncertain. We report the case of anastrozole-related acute hepatitis with some autoimmune features.
  
  
  METHODS
  A 70-year-old woman developed acute hepatitis associated with serum antinuclear antibodies during anastrozole treatment; after drug withdrawal, liver function parameters rapidly improved and serum auto-antibodies were no longer detectable.
  
  
  CONCLUSIONS
  Anastrozole-induced hepatotoxicity is a very rare event. Drug-drug interactions or metabolically-mediated damage might be involved, with a possible role of individual susceptibility. Our report suggests that an immune-mediated mechanism may also be considered in anastrozole-related liver injury.
authors: Division of Medical Oncology, Catholic University of Sacred Heart, Rome, Italy.
authors: Alessandro
authors: A
authors: Inno
authors: Michele
authors: M
authors: Basso
authors: Fabio M
authors: FM
authors: Vecchio
authors: Valentina A
authors: VA
authors: Marsico
authors: Eleonora
authors: E
authors: Cerchiaro
authors: Ettore
authors: E
authors: D'Argento
authors: Cinzia
authors: C
authors: Bagalà
authors: Carlo
authors: C
authors: Barone
mesh_terms: D000208:Acute Disease; D000368:Aged; D000077384:Anastrozole; D000974:Antibodies, Antinuclear / Q000097:blood; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D047072:Aromatase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000601:surgery; D002277:Carcinoma / Q000188:drug therapy / Q000601:surgery; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D009570:Nitriles / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000974:Antibodies, Antinuclear; D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole