title: Regioselective one pot synthesis of 3,3'-diindolylethylene derivatives and study of their cytotoxic activity.
abstract: 2,2'-Diphenyl-3,3'-diindolylethylene (DPDIE) derivatives 3a-g were regioselectively prepared in one pot from indoles 1a-g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited IC(50) of 13.0-17.0 μM.
authors: Department of Chemistry, Indian Institute of Chemical Biology (Unit of C.S.I.R), 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, India.
authors: Madhumita
authors: M
authors: Mandal
authors: Deepak
authors: D
authors: Kumar
authors: Rajneeta
authors: R
authors: Roy
authors: Rupashree
authors: R
authors: Sen
authors: Padma
authors: P
authors: Das
authors: Mitali
authors: M
authors: Chatterjee
authors: Parasuraman
authors: P
authors: Jaisankar
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D005030:Ethylenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005434:Flow Cytometry; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D005030:Ethylenes; D007211:Indoles; C036216:ethylene