title: Association between telomere length and C-reactive protein and the development of coronary collateral circulation in patients with coronary artery disease.
abstract: BACKGROUND
  Coronary collateral circulation is a stabilizer factor in myocardial ischemia. We attempted to establish a link between collateral circulation, C-reactive protein (CRP), and telomere shortening.
  
  
  METHODS
  A case-control study was performed in patients with (group A) and without (group B) coronary collaterals using coronariography. The patients were males, CRP levels and telomere length in circulating leucocytes were measured; Student t test and logistic regression were used to analyze the data.
  
  
  RESULTS
  The study included 40 patients aged 53.9 ± 7.0 years (20 per group). Group A exhibited lower CRP levels (2.76 ± 3.34 vs 4.04 ± 3.38; P = .004); whereas telomere length was shorter in group B (2.3 ± 6.9 kb vs 6.1 ± 5.9 kb; P < .0001).
  
  
  CONCLUSIONS
  Collateral circulation was associated with telomere shortening and elevation of CRP levels.
authors: Unit of Medical Research, UMAE No. 1 Bajio IMSS, Leon, Guanajuato, Mexico. soloriosergio@aol.com
authors: Sergio
authors: S
authors: Solorio
authors: Blanca
authors: B
authors: Murillo-Ortíz
authors: Martha
authors: M
authors: Hernández-González
authors: José
authors: J
authors: Guillén-Contreras
authors: Diego
authors: D
authors: Arenas-Aranda
authors: Francisco J
authors: FJ
authors: Solorzano-Zepeda
authors: Rene
authors: R
authors: Ruiz-Avila
authors: Carmen
authors: C
authors: Mora-Villalpando
authors: Jose M
authors: JM
authors: de la Roca-Chiapas
authors: Juan M
authors: JM
authors: Malacara-Hernández
mesh_terms: D002097:C-Reactive Protein / Q000502:physiology*; D016022:Case-Control Studies; D003097:Collateral Circulation; D003324:Coronary Artery Disease / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016615:Telomere / Q000648:ultrastructure*
chemical_list: D002097:C-Reactive Protein