title: Genetic polymorphisms ofCYP2A6 andCYP2E1 with tobacco smoking is not associated with risk of urothelial cancer.
abstract: OBJECTIVE
  To elucidate the association between genetic polymorphisms ofCYP2a6 andCYP2E1 and urothelial cancer susceptibility.
  
  
  METHODS
  A total of 137 Japanese patients with urothelial cancer and 217 Japanese healthy controls, frequency-matched for age and gender, were selected. The polymorphisms ofCYP2A6 andCYP2E1 were analyzed by PCR-RFLP, and cigarette smoking histories were obtained through interviews
  
  
  RESULTS
  The frequency ofCYP2A6 homozygote deletion genotype was 2.9% in the patients, compared with 3.2% in the controls (OR=0.84, 95% CI 0.24-2.96). The frequencies ofCYP2E1 C1/c2 andC2/c2 were 27.7% and 4.4% in the patients, compared with 35.5% and 6.0% in the controls (OR=0.68, 95% CI 0.42-1.09, OR=0.67, 95% CI 0.24-1.84, respectively). No statistically significant differences were observed when theCYP2A6 homozygote deletion genotype and theCYP2E1 genotypes were examined relative to smoking status.
  
  
  CONCLUSIONS
  Our data indicate that neither a relationship between genetically impaired nitrosamine metabolism and tobacco-smoking consumption, nor urothelial cancer risk related to theCYP2A6 deletion genotype andCYP2E1 Rsa I genotype was found in Japanese population.
authors: Department of Urology, Miyazaki Medical College, Miyazaki.
authors: Hiromasa
authors: H
authors: Tsukino
authors: Yoshiki
authors: Y
authors: Kuroda
authors: Hiroyuki
authors: H
authors: Nakao
authors: Hirohisa
authors: H
authors: Imai
authors: Yukio
authors: Y
authors: Osada
authors: Hisato
authors: H
authors: Inatomi
authors: Kyoko
authors: K
authors: Kitagawa
authors: Toshihiro
authors: T
authors: Kawamoto
authors: Takahiko
authors: T
authors: Katoh