title: Immunosuppressive activity of 8-gingerol on immune responses in mice.
abstract: 8-gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice. In the present study, we found that 8-gingerol suppressed lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro. In vivo, 8-gingerol not only signiﬁcantly suppressed Con A-, LPS- and OVA-induced splenocyte proliferation (P < 0.05) but also decreased the percentage of CD19+ B cells and CD3+ T cell (P < 0.05) at high doses (50, 100 mg/kg). Moreover, OVA-speciﬁc IgG, IgG1 and IgG2b levels in OVA-immunized mice were reduced by 8-gingerol at doses of 50, 100 mg/kg. These results suggest that 8-gingerol could suppress humoral and cellular immune responses in mice. The mechanism might be related to direct inhibition of sensitized T and B lymphocytes.
authors: Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China.
authors: Jing
authors: J
authors: Lu
authors: Shuang
authors: S
authors: Guan
authors: Xue
authors: X
authors: Shen
authors: Wenhui
authors: W
authors: Qian
authors: Guoren
authors: G
authors: Huang
authors: Xuming
authors: X
authors: Deng
authors: Guanghong
authors: G
authors: Xie
mesh_terms: D000818:Animals; D002396:Catechols / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice
chemical_list: D002396:Catechols; D005233:Fatty Alcohols; D007166:Immunosuppressive Agents; C534464:8-gingerol