title: Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines.
abstract: Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc β-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis.
authors: Laboratory of Synthetic Chemistry, SAIC-Frederick, Inc., National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, Maryland 21702, USA.
authors: Antonella
authors: A
authors: Pepe
authors: Michael
authors: M
authors: Pamment
authors: Gunda I
authors: GI
authors: Georg
authors: Sanjay V
authors: SV
authors: Malhotra
mesh_terms: D054836:Indolizidines / Q000138:chemical synthesis* / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D054837:Quinolizidines / Q000138:chemical synthesis* / Q000737:chemistry*; D047090:beta-Lactams / Q000737:chemistry
chemical_list: D054836:Indolizidines; D054837:Quinolizidines; D047090:beta-Lactams; D009584:Nitrogen