title: Congenital adrenal hyperplasia and Leydig cell tumor of testis. Case report and review of literature.
abstract: Adrenogenital Syndrome, more properly defined as Congenital Adrenal Hyperplasia (CAH), is related to the enzyme 21-beta-hydroxylase deficiency, with impaired glucocorticoids and aldosterone syntheses and increased ACTH synthesis. This report describes a case of a monorchid patient suffering from Adrenogenital Syndrome and Leydig cell tumor of his testis. A right orchidectomy with implantation of testis prosthesis was performed, after informing the patient on the consequences of his castration and obtaining his consent. Histology showed a testis measuring 4 x 3 x 2.5 cm with a 6 cm long spermatic cord; there was a yellowish, well-defined nodule measuring 3.5 x 1.5 cm, surrounded by normal parenchyma. This nodule had morphologic and immunohistochemical characteristics of a Leydig cell tumor, even found in the spermatic cord; those cells showed positivity to inibine, MART-1 and vimentine.
authors: Second University of Naples, School of Medicine, Unit of General and Geriatric Surgery, Naples, Italy.
authors: Antonio
authors: A
authors: Santoriello
authors: Raffaella
authors: R
authors: Benevento
authors: Pasquale
authors: P
authors: Petronella
authors: Giuseppe
authors: G
authors: Perna
authors: Silvestro
authors: S
authors: Canonico
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000150:complications*; D006801:Humans; D007984:Leydig Cell Tumor / Q000150:complications*; D008297:Male; D013736:Testicular Neoplasms / Q000150:complications*; D055815:Young Adult