title: Unraveling the biological roles of reactive oxygen species.
abstract: Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.
authors: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. Electronic address: mpm@mrc-mbu.cam.ac.uk.
authors: Michael P
authors: MP
authors: Murphy
authors: Department of Medical Biophysics and Biochemistry, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors: Arne
authors: A
authors: Holmgren
authors: Max Planck Institute for Biology of Ageing, Gleueler Straße 50a, 50931 Köln, Germany.
authors: Nils-Göran
authors: NG
authors: Larsson
authors: National University of Singapore, University Hall, Lee Kong Chian Wing, UHL #05-02G, 21 Lower Kent Ridge Road, Singapore 119077, Republic of Singapore.
authors: Barry
authors: B
authors: Halliwell
authors: Department of Chemistry, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA.
authors: Christopher J
authors: CJ
authors: Chang
authors: Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
authors: Balaraman
authors: B
authors: Kalyanaraman
authors: Division of Life and Pharmaceutical Sciences, Ewha Womans University, Science Building C, Room 103, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Korea.
authors: Sue Goo
authors: SG
authors: Rhee
authors: Clinical Sciences Research Institute, University of Warwick, University Hospital, Coventry CV2 2DX, UK.
authors: Paul J
authors: PJ
authors: Thornalley
authors: Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing, University College London, Gower Street, London WC1E 6BT, UK.
authors: Linda
authors: L
authors: Partridge
authors: Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing, University College London, Gower Street, London WC1E 6BT, UK.
authors: David
authors: D
authors: Gems
authors: Gothenburg University, 405 30 Göteborg, Sweden.
authors: Thomas
authors: T
authors: Nyström
authors: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia.
authors: Vsevolod
authors: V
authors: Belousov
authors: Northwestern University, Chicago, IL 60611, USA.
authors: Paul T
authors: PT
authors: Schumacker
authors: Department of Pathology, University of Otago, Christchurch 8011, New Zealand.
authors: Christine C
authors: CC
authors: Winterbourn
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species