title: Different expression of the catalytic alpha subunits of the AMP activated protein kinase--an immunohistochemical study in human tissue.
abstract: AMPK is an ubiquitously distributed multienzyme complex. It is an important energy sensor and regulator of cellular metabolic activity. In this study we analyzed for the first time the cellular distribution of the catalytically active subunits AMPKα1 and α2 in different human tissues by immunohistochemistry. We found different expression patterns for both isoforms. AMPKα2 expression clearly dominates in skeletal myocytes and cardiomyocytes, whereas AMPKα1 dominates in a number of secreting cells, like mammary glands, islets of langerhans and cells of the colon crypts.
authors: Department of Pediatric Cardiology and Pediatric Intensive Care Medicine, Georg-August University, Göttingen, Germany. thomas.quentin@med.uni-goettingen.de
authors: Thomas
authors: T
authors: Quentin
authors: Julia
authors: J
authors: Kitz
authors: Michael
authors: M
authors: Steinmetz
authors: Andrea
authors: A
authors: Poppe
authors: Karin
authors: K
authors: Bär
authors: Ralph
authors: R
authors: Krätzner
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000096:biosynthesis*; D015153:Blotting, Western; D020134:Catalytic Domain; D015971:Gene Expression Regulation, Enzymologic; D006367:HeLa Cells; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D007515:Islets of Langerhans / Q000378:metabolism; D018482:Muscle, Skeletal / Q000166:cytology; D032383:Myocytes, Cardiac / Q000378:metabolism; D020033:Protein Isoforms; D014018:Tissue Distribution
chemical_list: D020033:Protein Isoforms; C526181:PRKAA2 protein, human; D055372:AMP-Activated Protein Kinases; C526180:PRKAA1 protein, human