title: Vitamin D and the vitamin D receptor in liver pathophysiology.
abstract: Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis. The liver is central in vitamin D synthesis, however the direct involvement of the vitamin D-VDR axis on the liver remains to be evaluated. In this review, we will describe vitamin D metabolism and the mechanisms of homeostatic control. We will also address the associations between the vitamin D-VDR axis and pathological liver entities, such as non-alcoholic fatty liver disease, autoimmune liver disease, viral hepatitis and liver cancer. The link between liver diseases and the vitamin D-VDR axis will be discussed in light of evidences arising from in vitro and in vivo studies. Finally, we will consider the therapeutic potential of the vitamin D-VDR axis in liver diseases.
authors: UPMC University Paris 06, UMR_S 938, CdR Saint-Antoine, 75005 Paris, France.
authors: Silvia
authors: S
authors: Zúñiga
authors: Delphine
authors: D
authors: Firrincieli
authors: Chantal
authors: C
authors: Housset
authors: Nicolas
authors: N
authors: Chignard
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000503:physiopathology*; D008107:Liver Diseases / Q000378:metabolism / Q000503:physiopathology*; D018167:Receptors, Calcitriol / Q000502:physiology*; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology*
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D