title: The chelation targeting metal-Aβ40 aggregates may lead to formation of Aβ40 oligomers.
abstract: The fluorescent chelator (FC-1) was designed by combining a metal-chelating unit and a ThT-based Aβ aggregate-binding fluorescent unit. FC-1 is a cell membrane-penetrable chelator with a moderate chelation ability to Cu(2+) and Zn(2+) and can target metal-Aβ40 aggregates. Treatment with FC-1 led to enhanced cytotoxicity of the aggregates, because the aggregates were converted into a pool of oligomers.
authors: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, School of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
authors: Yong
authors: Y
authors: Zhang
authors: Li-Yuan
authors: LY
authors: Chen
authors: Wen-Xing
authors: WX
authors: Yin
authors: Jun
authors: J
authors: Yin
authors: Shi-Bing
authors: SB
authors: Zhang
authors: Chang-Lin
authors: CL
authors: Liu
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D002614:Chelating Agents / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry / Q000633:toxicity; D003300:Copper / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008670:Metals / Q000737:chemistry*; D008968:Molecular Conformation; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism; D015032:Zinc / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D002614:Chelating Agents; D056831:Coordination Complexes; D008670:Metals; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D003300:Copper; D015032:Zinc