title: The immunosuppressive side of PDT.
abstract: Photodynamic therapy (PDT) is a promising novel therapeutic procedure for the management of a variety of solid tumors and many non-malignant diseases. PDT has been described as having a significant effect on the immune system, which may be either immunostimulatory or, in some circumstances, immunosuppressive. The immunosuppressive effects of PDT have nearly all been concerned with the suppression of the contact hypersensitivity reaction in mice. Here, we review the immunosuppressive aspects of PDT treatment and discuss some additional mechanisms that may be involved.
authors: Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA. pmroz@partners.org
authors: Pawel
authors: P
authors: Mroz
authors: Michael R
authors: MR
authors: Hamblin
mesh_terms: D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000627:therapeutic use; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy; D016038:Skin Transplantation / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents