title: Hirsutosterols A-G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta.
abstract: Seven new polyoxygenated steroids, hirsutosterols A-G (1-7), were isolated from the Formosan soft coral Cladiella hirsuta. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configurations of 1 and 5 were determined by Mosher's method. Sterols 4-6 possess hydroxy groups at C-9 and C-11 and might be oxidatively cleaved to the corresponding 9,11-secosterols. Hirsutosterol A (1) was found to exhibit a stronger cytotoxicity against a limited panel of cancer cell lines.
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 804, Taiwan.
authors: Bo-Wei
authors: BW
authors: Chen
authors: Shu-Ming
authors: SM
authors: Chang
authors: Chiung-Yao
authors: CY
authors: Huang
authors: Jui-Hsin
authors: JH
authors: Su
authors: Zhi-Hong
authors: ZH
authors: Wen
authors: Yang-Chang
authors: YC
authors: Wu
authors: Jyh-Horng
authors: JH
authors: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D006900:Hydroxylation; D007536:Isomerism; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D013256:Steroids; D010100:Oxygen