title: [The influence of diet with reduction in calorie intake on metabolic syndrome parameters in obese subjects with impaired glucose tolerance].
abstract: BACKGROUND
  Current therapy of metabolic syndrome includes the assessment of cardiovascular risk together with control of high blood pressure, hyperlipidaemia and prevention of type 2 diabetes with adequate diet and increase in physical activity.
  
  
  OBJECTIVE
  To investigate the influence of medical nutritive therapy in obese people with impaired glucose tolerance risk factor for Type 2 Diabetes mellitus and potential consecutive lowering of cardiometabolic risk.
  
  
  METHODS
  The 55 obese (body mass index greater than 30 kg/m2) subjects were divided into two groups, the study group A (n = 35), and the control group B (n = 20). Group A was on diet for a period of 12 weeks (1200-1500 kcal/day diet with 55-65% carbohydrates, 15-18% proteins and 22-23% predominantly unsaturated fats, and 20-40 g fibers/day.). Before and after 12 weeks the following parameters were determined: waist circumference, blood pressure, fasting plasma glucose, Index HOMA-IR, HDL cholesterol and triglycerides.
  
  
  RESULTS
  After 12 weeks on low calorie diet in Group A there was a decrease in the waist circumference (p = 0.001); systolyc blood pressure (p = 0.001); diastolic blood pressure (p = 0.01); fasting blood glucose (p = 0.001); Index HOMA IR (p < 0.001); triglycerides (p < 0.001) and increase in HDL cholesterol (p < 0.05).
  
  
  CONCLUSIONS
  These results suggest that implementation of low calorie-high fibers diet with balanced nutritive elements have a positive effect on visceral obesity, fasting glucose, lipid profile, and hypertension in obese people with impaired glucose tolerance and lead to consecutive lowering of cardiometabolic risk.
authors: Opsta bolnica Subotica, Subotica. snendo4@yahoo.com
authors: Snezana
authors: S
authors: Polovina
authors: Dragan
authors: D
authors: Micić
mesh_terms: D015992:Body Mass Index; D031204:Caloric Restriction; D005260:Female; D018149:Glucose Intolerance / Q000150:complications*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D009765:Obesity / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology