title: Effects of quinazolinones on Balb/C mice embryonic livers.
abstract: Heterocyclic compounds such as quinazolinones have variety of biological and pharmacological properties (anticancer, antiinflammatory, antimicrobial, antimalaria, etc.). Effects of two new quinazolinones viz., 4(3H)-quinazolinone-2-propyl-2-phenylethyl (QPPE) and 4(3H)quinazolinone-2-ethyl-2-phenylethyl (QEPE) were investigated on Balb/C mice embryos livers-the major organ of metabolism and detoxification of drugs and toxins. Histological and pathological studies demonstrated QPPE and QEPE as producers of toxic metabolites after biotransformation, creating necrosis, fatty changes, increase in the number of band cells, hepatocytes' diameters and alkaline phosphatase, in addition to sinusoid dilation, hemorrhages and hyperemia. Transmission electron micrographs showed lipid droplets in hepatocytes' cytoplasm, necrosis, vacuolization, cytoplasm disintegration, disfigured and swollen mitochondria, irregular and abnormal nuclei, nuclei with heterochromatin, condensed chromatins, myelin figures and autophages in injured hepatocytes. In conclusion, QPPE and QEPE make toxic components after biotransformation injuring membranes and creating inflammatory reactions. They also disturb metabolism of lipids pathways and cause the appearances of lipid droplets in hepatocytes.
authors: Developmental Biology, Animal Sciences, Faculty of Biological Sciences, Shahid-Beheshti University, G C, Tehran, Iran. mslahijani2006@gmail.com
authors: Lahijani Maryam
authors: LM
authors: Shams
authors: Dariush
authors: D
authors: Minaei-Tehrani
authors: Hadis
authors: H
authors: Gholipour
authors: Masumeh
authors: M
authors: Nohehkhan
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000196:embryology / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001711:Biotransformation; D005260:Female; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000002:abnormalities* / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D052999:Quinazolinones / Q000493:pharmacokinetics / Q000633:toxicity*; D013723:Teratogens / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D052999:Quinazolinones; D013723:Teratogens