title: Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era.
abstract: Human polyomavirus JC is the causative agent of a deadly form of sudden onset dementia, progressive multifocal leukocoencephalopathy (PML). PML is highly prevalent in immunodeficient populations, specially those undergoing chemotherapy, immunosuppressive treatments for autoimmune conditions, and HIV-1/AIDS patients. In fact, before the highly active antiretroviral therapy (HAART) regimens became available, PML was a leading cause of death in HIV-1 seropositive individuals. However, patients under HAART show increased survival times with better prognoses. In this report we described the main differences between PML before and after the HAART era; highlighting the new patterns of presentation, the neurotropism of other human polyomaviruses, and the increased prevalence of immune reconstitution inflammatory syndrome (IRIS), as a complication of PML in patients under HAART. Lastly, we propose a revised classification of human poliomavirus-associated cerebral disorders that may reflect more accurately what clinicians encounter in their everyday practice.
authors: Harvard Medical School, Boston, MA 02215, USA.
authors: Filiberto
authors: F
authors: Cedeno-Laurent
authors: Augusto C
authors: AC
authors: Penalva de Oliveira
authors: José E
authors: JE
authors: Vidal
authors: J Roberto
authors: JR
authors: Trujillo