title: Functional involvement of Ca(2+) and Ca(2+)-activated K(+) channels in anethol-induced changes in Ca(2+) dependent excitability of F1 neurons in Helix aspersa.
abstract: The effects of anethol, the major component of anise oil, on the Ca(2+)-dependent excitability and afterhyperpolarization (AHP) in snail neurons were examined using intracellular recording. Anethol (0.5%) significantly broadened the spike, reduced the firing frequency and enhanced the AHP amplitude. In contrast, anethol (2%) significantly increased the firing frequency and decreased the AHP. Blockade of Ca(2+) channels after anethol application depolarized the membrane potential and significantly reduced the firing rate. Furthermore, in the presence of anethol (0.5%) a significant decrease in the AHP was observed by Ca(2+) channels blockage. Here, anethol-induced functional modification of Ca(2+) and Ca(2+)-activated K(+) channels is suggested.
authors: Neuroscience Research Centre and Dept. of Physiology, Medical School, Shahid Beheshti University of Medical Sciences, Evin, Tehran, Islamic Republic of Iran.
authors: Zahra
authors: Z
authors: Ghasemi
authors: Majid
authors: M
authors: Hassanpour-Ezatti
authors: Mohammad
authors: M
authors: Kamalinejad
authors: Mahyar
authors: M
authors: Janahmadi
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D006372:Helix, Snails; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D028042:Pimpinella / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D024681:Potassium Channels, Calcium-Activated / Q000187:drug effects* / Q000502:physiology
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; D015220:Calcium Channels; D010936:Plant Extracts; D024681:Potassium Channels, Calcium-Activated; C006578:anethole; D002118:Calcium