title: Sleep-disordered breathing and excessive daytime sleepiness in chronic kidney disease and hemodialysis.
abstract: OBJECTIVE
  Sleep-disordered breathing (SDB) and excessive daytime sleepiness (EDS) are highly prevalent among hemodialysis (HD) patients. It is unclear to what extent SDB is associated with advanced chronic kidney disease (CKD; stages 4 to 5). This paper describes and compares the prevalence, severity, and patterns of SDB and EDS among patients with advanced CKD, HD-dependent patients, and community individuals without known renal disease.
  
  
  METHODS
  Eighty-nine CKD and 75 HD patients were compared with 224 participants from the Sleep-Strategies Concentrating on Risk Evaluation Sleep-SCORE study of sleep and cardiovascular risk. Participants had in-home unattended polysomnography for quantifying SDB. EDS was defined by a score ≥10 on the Epworth Sleepiness Scale.
  
  
  RESULTS
  The sample had a median age 58.1 years, was predominantly male (57.4%) and white (62.5%), and had a median body mass index of 28.1 kg/m(2). Controls and Sleep-SCORE Study CKD patients had significantly higher median total sleep time and sleep efficiency compared with HD patients. The adjusted odds of severe SDB were higher for CKD and HD groups compared with the controls. Nocturnal hypoxemia was significantly elevated in the HD group compared with the CKD group. There were similar proportions of participants with EDS between the controls (33%), the CKD patients (29.3%), and the HD patients (40.6%).
  
  
  CONCLUSIONS
  Severe SDB (predominantly obstructive) and EDS are common among advanced CKD and HD patients. EDS correlated modestly with severe SDB and its obstructive and mixed patterns in the HD group.
authors: Renal-Electrolyte Division, University of Pittsburgh School of Medicine, 200 Lothrop Street, PUH C-1111, Pittsburgh, PA 15213, USA. meroumeliotou@gmail.com
authors: Maria-Eleni
authors: ME
authors: Roumelioti
authors: Daniel J
authors: DJ
authors: Buysse
authors: Mark H
authors: MH
authors: Sanders
authors: Patrick
authors: P
authors: Strollo
authors: Anne B
authors: AB
authors: Newman
authors: Mark L
authors: ML
authors: Unruh
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017286:Polysomnography; D015995:Prevalence; D006435:Renal Dialysis / Q000706:statistics & numerical data*; D012720:Severity of Illness Index; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000453:epidemiology*; D012894:Sleep Stages