title: Statins for progression of aortic valve stenosis and the best evidence for making decisions in health care.
abstract: In the Western world, calcified aortic valve stenosis is the most common form of valvular heart disease, affecting up to 3% of adults over the age of 75 years. It is a gradually progressive disease, characterized by a long asymptomatic phase that may last for several decades, followed by a short symptomatic phase associated with severe restriction of the valve orifice. Investigations on treatments for aortic valve stenosis are still in progress. Thus, it is believed that calcification of aortic valve stenosis is similar to the process of atherosclerosis that occurs in coronary artery disease. Recent studies have suggested that cholesterol lowering through the use of statins may have a salutary effect on the progression of aortic valve stenosis.
authors: Faculdade de Medicina de Marília, Marília, São Paulo, Brazil. dralucianathiago@yahoo.com.br
authors: Luciana
authors: L
authors: Thiago
authors: Selma Rumiko
authors: SR
authors: Tsuj
authors: Alvaro Nagib
authors: AN
authors: Atallah
authors: Maria Eduarda dos Santos
authors: ME
authors: Puga
authors: Aécio Flávio Teixeira
authors: AF
authors: de Góis
mesh_terms: D001024:Aortic Valve Stenosis / Q000188:drug therapy*; D002114:Calcinosis / Q000188:drug therapy*; D008078:Cholesterol, LDL / Q000187:drug effects; D018450:Disease Progression; D019317:Evidence-Based Medicine; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*
chemical_list: D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors