title: The histamine H2 receptor antagonist lafutidine in Japanese patients with non-erosive reflux disease.
abstract: OBJECTIVE
  This study aims to investigate whether histamine H2-receptor antagonists are sufficient to treat nonerosive reflux disease in Japanese patients. The efficacy of lafutidine in Japanese nonerosive reflux disease patients was studied.
  
  
  METHODS
  The subjects were 24 heartburn patients with two or more cases of heartburn in a week before the period of observation, QUEST score of 6 or above and diagnosed as no erosion in esophagus by upper gastrointestinal endoscopy. Following obtained informed consent, gastroesophageal 24-hour pH was monitored after the placebo period (2 weeks) and the completion of the lafitidine period (at the dose of 10 mg twice daily for 4 weeks).
  
  
  RESULTS
  Twenty three patients completed the study. The percentage of time that the intraesophageal pH was less than 4 decreased significantly, from 3.07% to 1.17%, after the lafutidine administration. The overall percentage of time that the intragastric pH was above 3 increased significantly from 26.6% to 56.5% after the lafutidine administration, and increased from 22.7% to 51.0% (daytime period) and 34.6% to 67.2% (nighttime period), respectively. Lafutidine markedly improved heartburn and other symptoms, as recorded in patient diaries.
  
  
  CONCLUSIONS
  Lafutidine markedly improved the intraesophageal pH and the symptoms of heartburn in Japanese patients with nonerosive reflux disease. Lafutidine also inhibited gastric acid secretion not only during the nighttime but also during the daytime.
authors: Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. inamorim@med.yokohama-cu.ac.jp
authors: Masahiko
authors: M
authors: Inamori
authors: Hiroshi
authors: H
authors: Iida
authors: Kunihiro
authors: K
authors: Hosono
authors: Hirohi
authors: H
authors: Endo
authors: Yasunari
authors: Y
authors: Sakamoto
authors: Hirohazu
authors: H
authors: Takahashi
authors: Tomoko
authors: T
authors: Koide
authors: Chikako
authors: C
authors: Tokoro
authors: Ayumu
authors: A
authors: Goto
authors: Yasunobu
authors: Y
authors: Abe
authors: Noboru
authors: N
authors: Hiratsuka
authors: Atsushi
authors: A
authors: Nakajima
authors: Masami
authors: M
authors: Fujita
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D050782:Esophageal pH Monitoring; D005260:Female; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D006635:Histamine H2 Antagonists; D010880:Piperidines; D011725:Pyridines; C076948:lafutidine