title: Shape dependence of gold nanoparticles on in vivo acute toxicological effects and biodistribution.
abstract: The toxicity and biodistribution in vivo of various morphologies of Au nanoparticles (AuNPs) were studied by using KM mice. The quantitative analysis of Au in each tissue of mice was done by using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Sphere-shaped AuNPs displayed the best biocompatibility, compared with rod- and cube-shaped of AuNPs, and rod-shaped AuNPs was more toxic than cube-shaped AuNPs. In vivo biodistribution study revealed all AuNPs were preferentially accumulated in organ of liver and spleen. The findings from this study thus revealed that the toxicity and biodistribution in vivo of AuNPs are shape dependent.
authors: Research Center of Biomedical Engineering, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, PR China.
authors: Ya-Nan
authors: YN
authors: Sun
authors: Cai-Ding
authors: CD
authors: Wang
authors: Xiu-Ming
authors: XM
authors: Zhang
authors: Lei
authors: L
authors: Ren
authors: Xin-Hua
authors: XH
authors: Tian
mesh_terms: D000818:Animals; D006046:Gold / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D006461:Hemolysis / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D013058:Mass Spectrometry; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000633:toxicity* / Q000648:ultrastructure*; D051379:Mice; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology; D010316:Particle Size; D014018:Tissue Distribution
chemical_list: D006046:Gold