title: ROCK: the Roche medicinal chemistry knowledge application - design, use and impact.
abstract: Medicinal chemistry is a complex science that lies at the interface of many fields of research and at the very heart of drug discovery, with property relationships based on chemical structure at its core. It is clear that the effective capture and dissemination of medicinal chemistry knowledge and experience will be a key differentiator among pharmaceutical organizations and crucial for the future success in delivering effective and safe drug candidates. Therefore, in 2005 we developed ROCK (Roche medicinal chemistry knowledge), an internal user-friendly and peer-reviewed Wiki-like application to capture, browse and search tacit knowledge, key discoveries and property effects related to chemical structure, which is used as a primary source for addressing challenges faced in drug design.
authors: F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Discovery Chemistry, CH-4070 Basel, Switzerland. alexander_v.mayweg@roche.com
authors: Alexander
authors: A
authors: Mayweg
authors: Urs
authors: U
authors: Hofer
authors: Patrick
authors: P
authors: Schnider
authors: Fausto
authors: F
authors: Agnetti
authors: Guido
authors: G
authors: Galley
authors: Patrizio
authors: P
authors: Mattei
authors: Matthew
authors: M
authors: Lucas
authors: Hans-Joachim
authors: HJ
authors: Boehm
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods; D004345:Drug Industry / Q000379:methods*; D006801:Humans; D010380:Peer Review; D012107:Research Design