title: Prostaglandin D₂ and T(H)2 inflammation in the pathogenesis of bronchial asthma.
abstract: Prostaglandin D₂ (PGD₂) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD₂-induced vasodilatation and increased permeability are well-known classical effects that may be involved in allergic inflammation. Recently, novel functions of PGD₂ have been identified. To date, D prostanoid receptor (DP) and chemoattractant receptor homologous molecule expressed on T(H)2 cells (CRTH2) have been shown to be major PGD₂-related receptors. These two receptors have pivotal roles mediating allergic diseases by regulating the functions of various cell types, such as T(H)2 cells, eosinophils, basophils, mast cells, dendritic cells, and epithelial cells. This review will focus on the current understanding of the roles of PGD₂ and its metabolites in T(H)2 inflammation and the pathogenesis of bronchial asthma.
authors: Department of Developmental Genetics (H2), Chiba University Graduate School of Medicine, Chiba, Japan. masaarima@faculty.chiba-u.jp
authors: Masafumi
authors: M
authors: Arima
authors: Takeshi
authors: T
authors: Fukuda
mesh_terms: D001249:Asthma / Q000209:etiology* / Q000276:immunology; D001491:Basophils / Q000502:physiology; D004804:Eosinophils / Q000502:physiology; D006801:Humans; D008407:Mast Cells / Q000502:physiology; D015230:Prostaglandin D2 / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology; D011982:Receptors, Prostaglandin / Q000502:physiology; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D015230:Prostaglandin D2; C036293:prostaglandin D2 receptor