title: An audit of combined multichannel intraluminal impedance manometry in the assessment of dysphagia.
abstract: BACKGROUND
  Multichannel Intraluminal Impedance (MII) Monitoring is a method of examining oesophageal bolus transit without the need for radiation. In combination with oesophageal manometry it allows correlation of bolus transit with peristaltic activity. The clinical application of impedance manometry is still being refined. This audit looked to examine whether impedance manometry had advantages over standard manometry in assessment of patients with dysphagia.
  
  
  METHODS
  41 patients with the presenting symptom of dysphagia were assessed by combined MII and oesophageal manometry at a Wellington Hospital between February 2008 and December 2009. Each underwent manometry and MII using standardised techniques.
  
  
  RESULTS
  Achalasia was diagnosed in 23 patients (56.1%), Ineffective oesophageal motility (IEM) in 5 patients (12.2%), Diffuse oesophageal Spasm (DES) in 7 patients (17.1%), and Nutcracker oesophagus in 2 patients (4.9%). 4 patients had normal manometry studies (9.8%). All patients with achalasia, IEM, and DES had abnormal bolus transit. All patients with normal manometry had abnormal bolus transit. Both patients with nutcracker oesophagus had normal bolus transit. 4 patients with achalasia had undergone previous Hellers myotomy. Two of these patients (50.0%) now had normal LES relaxation pressures, but all four still had abnormal oesophageal peristalsis and abnormal bolus transit.
  
  
  CONCLUSIONS
  Multichannel Intraluminal Impedance manometry has advantages over standard manometry in characterising the physiological abnormalities associated with dysphagia. Patients in this study had severe defects including achalasia where bolus transit was invariably poor meaning little further information was gained. Extension of this study to include a wider group of patients with dysphagia may yield different results.
authors: Wellington Gastroenterology Department, Wellington Hospital Riddiford St, Wellington, New Zealand. nicholas.burgess@ccdhb.org.nz
authors: Nicholas G
authors: NG
authors: Burgess
authors: John W
authors: JW
authors: Wyeth
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003679:Deglutition; D003680:Deglutition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D017097:Electric Impedance; D004931:Esophageal Achalasia / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D015154:Esophageal Motility Disorders / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D015155:Esophageal Spasm, Diffuse / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods*; D008485:Medical Audit; D008875:Middle Aged; D009520:New Zealand; D010528:Peristalsis; D011237:Predictive Value of Tests; D011312:Pressure; D012720:Severity of Illness Index