title: Parkin uses the UPS to ship off dysfunctional mitochondria.
abstract: Parkin is a ubiquitin E3 ligase that is implicated in familial Parkinson disease (PD). Previous studies have established its role in mitophagy, a pathway whereby dysfunctional mitochondria are targeted for autophagic degradation. We recently reported that a major function of Parkin in dysfunctional mitochondria is to activate the ubiquitin-proteasome system (UPS) for proteolysis of multiple outer membrane proteins, and that such activation of the UPS is a critical step in Parkin-mediated mitophagy. Here, we discuss the possible roles of the UPS in mitophagy and the pathogenesis of PD.
authors: Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA, USA.
authors: Nickie C
authors: NC
authors: Chan
authors: David C
authors: DC
authors: Chan
mesh_terms: D000818:Animals; D001343:Autophagy; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology*; D008954:Models, Biological; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D046988:Proteasome Endopeptidase Complex