title: [Study on volatile components from peel of Aquilaria sinensis and the anti-tumor activity].
abstract: OBJECTIVE
  To study the volatile constituents from peel of Aquilaria sinensis (Lour.) Gilg. and its anti-tumor activity.
  
  
  METHODS
  The volatile components from peel of A. sinensis were extracted by chloroform and analysed by the GC-MS technique. Assay the peel extract of A. sinensis on MCF-7 cell proliferation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) method.
  
  
  RESULTS
  GC-MS gave 131 peaks and 28 compounds have been identified. The contents of the benzene compounds accounted 7.79% of the volatile components, the esquiterpenes accounted 5.44%, and the relative content of fatty acids accounted 3.08%. In addition, two 2-(2-phenylethyl)-color ketones and a chromone component were detected, and the total relative content accounted 12.3%. The inhibition rate of human breast cancer cells reached 99. 6% when the concentration was 500 microg/mL.
  
  
  CONCLUSIONS
  The volatile components from peel of A. sinensis were analysed and a large number of characteristic elements of A. sinensis were detected for the first time. The chloroform extract from peel of A. sinensis significantly inhibited the proliferation of human breast cancer cells.
authors: Guangdong Pharmacetical University, Guangzhou 510006, China. girlweina.2008@163.com
authors: Wei-Na
authors: WN
authors: Xu
authors: Xiao-Xia
authors: XX
authors: Gao
authors: Xiao-Ling
authors: XL
authors: Guo
authors: Yu-Chan
authors: YC
authors: Chen
authors: Wei-Min
authors: WM
authors: Zhang
authors: Yuan-Sheng
authors: YS
authors: Luo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D050339:Benzylammonium Compounds / Q000032:analysis* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002867:Chromones / Q000032:analysis / Q000494:pharmacology; D005227:Fatty Acids / Q000032:analysis / Q000494:pharmacology; D005260:Female; D005638:Fruit / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D009822:Oils, Volatile / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D012717:Sesquiterpenes / Q000032:analysis* / Q000494:pharmacology; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D050339:Benzylammonium Compounds; D002867:Chromones; D005227:Fatty Acids; D009822:Oils, Volatile; D012717:Sesquiterpenes