title: Mucin 13: structure, function, and potential roles in cancer pathogenesis.
abstract: Mucin 13 (MUC13) is a high-molecular-weight transmembrane glycoprotein that is frequently and aberrantly expressed in a variety of epithelial carcinomas, including gastric, colorectal, and ovarian cancers. On the basis of the high expression of MUC13 in cancer cells as well as recent laboratory findings suggesting a malignant phenotype of MUC13-transfected cell lines, the oncogenic potential of MUC13 has emerged. The various functional domains of MUC13 may confer oncogenic potential to MUC13. For example, the bulky extracellular domain with extensive modification with glycan chains may prevent cell-cell and cell-extracellular matrix binding whereas the cytoplasmic tail containing serine and tyrosine residues for potential phosphorylation may participate in cell signaling. MUC13 exhibits the characteristics suitable as an early marker for cancer screening and presents a promising target for antibody-guided targeted therapy.
authors: Cancer Biology Research Center, Sanford Research/USD.
authors: Diane M
authors: DM
authors: Maher
authors: Cancer Biology Research Center, Sanford Research/USD.|Basic Biomedical Science Division, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota.
authors: Brij K
authors: BK
authors: Gupta
authors: Cancer Biology Research Center, Sanford Research/USD.
authors: Satoshi
authors: S
authors: Nagata
authors: Cancer Biology Research Center, Sanford Research/USD.|Department of Obstetrics and Gynecology, The University of South Dakota, Sioux Falls, South Dakota.|Basic Biomedical Science Division, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota.
authors: Meena
authors: M
authors: Jaggi
authors: Cancer Biology Research Center, Sanford Research/USD.|Department of Obstetrics and Gynecology, The University of South Dakota, Sioux Falls, South Dakota.|Basic Biomedical Science Division, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota.
authors: Subhash C
authors: SC
authors: Chauhan
mesh_terms: D000595:Amino Acid Sequence; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005260:Female; D006031:Glycosylation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D009077:Mucins / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism*; D015513:Oncogene Proteins / Q000737:chemistry / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000378:metabolism*; D010766:Phosphorylation; D011230:Precancerous Conditions / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D009077:Mucins; D015513:Oncogene Proteins; D011956:Receptors, Cell Surface