title: A randomized controlled trial of endoscopist vs. anaesthetist-administered sedation for colonoscopy.
abstract: BACKGROUND
  Endoscopist-administered propofol sedation for colonoscopy has not been compared to anaesthetist-administered deep sedation in clinical trials. Our aim was to compare patients' satisfaction and safety during these two sedation modalities.
  
  
  METHODS
  90 adult patients undergoing colonoscopy were randomized into Group A, Endoscopist-administered propofol sedation and Group B, anaesthetist-administered deep sedation. Group A patients received an initial dose of 30-50 mg of intravenous propofol; additional doses were injected by the endoscopist using a pre-programmed pump. Global satisfaction was measured on a 0-100 mm visual analogue scale.
  
  
  RESULTS
  The average satisfaction scores after examination completion amongst group were not statistically different (90.8 mm for Group A vs. 89 mm for Group B). Group A patients expressed more frequently a good level of satisfaction (95% vs. 75%; p=0.03) and willingness to undergo further colonoscopies under the same conditions (95% vs. 79%; p=0.02). Total duration time and procedural difficulty did not differ between the groups. Group A received a lower total propofol dose than Group B (94 mg vs. 260 mg) and experienced fewer side-effects (16 vs. 3, respectively; p < 0.008).
  
  
  CONCLUSIONS
  Endoscopist-administered propofol sedation for colonoscopy offered a better level of satisfaction and fewer side-effects than anaesthetist-administered deep sedation.
authors: Clermont University, Auvergne University, Clermont-Ferrand, France.
authors: Laurent
authors: L
authors: Poincloux
authors: Arthur
authors: A
authors: Laquière
authors: Jean-Etienne
authors: JE
authors: Bazin
authors: Frederic
authors: F
authors: Monzy
authors: Fabrice
authors: F
authors: Artigues
authors: Corinne
authors: C
authors: Bonny
authors: Armand
authors: A
authors: Abergel
authors: Michel
authors: M
authors: Dapoigny
authors: Gilles
authors: G
authors: Bommelaer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D003113:Colonoscopy / Q000379:methods*; D016292:Procedural Sedation / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D017060:Patient Satisfaction; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol