title: Langerhans cell histiocytosis of the sphenoid sinus: a case report.
abstract: Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is a rare disorder characterized by clonal proliferation and excess accumulation of pathologic Langerhans cells causing local or systemic effects. Bone is the most common organ involved and a single skull lesion is the most frequent presentation of childhood LCH. However, sphenoid sinus is an uncommon condition of involvement in LCH. Here we report a case of LCH in the sphenoid sinus, which occurred in a seven-year-old girl who presented initially with headache. The girl had suffered from headache for one month before she went to an otorhinolaryngologist one week before. Magnetic resonance imaging (MRI) showed a lesion of inflammatory granuloma. Surgery was performed and the disease was diagnosed pathologically as single-site LCH via hematoxylin-eosin (H&E) and immunohistochemical staining.
authors: Department of Pathology, Yuhuangding Hospital, China.
authors: Guohua
authors: G
authors: Yu
authors: Fei
authors: F
authors: Huang
authors: Lingling
authors: L
authors: Kong
authors: Xiangmei
authors: X
authors: Kong
authors: Luping
authors: L
authors: Zhang
authors: Qing
authors: Q
authors: Xu
mesh_terms: D002648:Child; D004803:Eosinophilic Granuloma / Q000150:complications / Q000473:pathology / Q000601:surgery; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D013101:Sphenoid Sinus