title: Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles.
abstract: BACKGROUND
  Polybutylcyanoacrylate (PBCA) nanoparticles coated with polysorbate-80 have been extensively proposed for delivering drugs into the animal brain and have shown great potential for therapeutic applications. In this study, we made an attempt to deliver the chemotherapeutic drug, temozolomide, into the brain by using PBCA nanoparticles. The physicochemical characteristics, in vitro release, and brain targeting ability of the drug-loaded nanoparticles were investigated.
  
  
  RESULTS
  Our results show that a significantly higher concentration of temozolomide in the form of polysorbate-80-coated PBCA nanoparticles was observed in the brain (P < 0.05) in comparison with the free drug.
  
  
  CONCLUSIONS
  This study indicates that polysorbate-80 coated PBCA nanoparticles could be a feasible carrier for temozolomide delivery to the brain. It is anticipated that the developed formulation may improve on targeted therapy for malignant brain tumors in the future.
authors: Department of Neurosurgery, Zhongshan Hospital of Xiamen University, Xiamen, People's Republic of China.
authors: Xin-Hua
authors: XH
authors: Tian
authors: Xiao-Ning
authors: XN
authors: Lin
authors: Feng
authors: F
authors: Wei
authors: Wei
authors: W
authors: Feng
authors: Zhi-Chun
authors: ZC
authors: Huang
authors: Peng
authors: P
authors: Wang
authors: Lei
authors: L
authors: Ren
authors: Yi
authors: Y
authors: Diao
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000188:drug therapy; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000008:administration & dosage* / Q000648:ultrastructure; D009928:Organ Specificity; D011136:Polysorbates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared; D000077204:Temozolomide
chemical_list: D011136:Polysorbates; D003606:Dacarbazine; D000077204:Temozolomide