title: Risk factors for early recurrence after curative hepatectomy for colorectal liver metastases.
abstract: OBJECTIVE
  With the broadening indications for hepatectomy to treat colorectal liver metastases (CRLM), early recurrence is a major problem. The aim of this study is to identify risk factors of early recurrence, defined as recurrence within 1 year after surgery.
  
  
  METHODS
  A retrospective analysis was performed on 121 consecutive patients who underwent hepatectomy for CRLM.
  
  
  RESULTS
  Among 121 patients, 52 (43.0%) developed early recurrence. The independent risk factor for early recurrence was "number of liver metastases ≥ 3" (odds ratio 2.65). There were significantly more patients with liver recurrence (51.9%) and recurrence beyond curative surgical resection (63.5%) in those with early recurrence. In addition, patients with three or more liver metastases had significantly more liver recurrence (66.7%; P = 0.02) and recurrence beyond curative surgical resection (70.8%; P = 0.04). The overall survival rates of both patients with early recurrence (5-year survival rate 20%) and those with three or more liver metastases (5-year survival rate 24%) were significantly worse.
  
  
  CONCLUSIONS
  The independent risk factor for early recurrence is the "number of liver metastases ≥ 3." Patients with three or more liver metastases have a significantly higher risk of liver recurrence and a higher rate of recurrence beyond curative surgical resection, and these are correlated with a poor prognosis.
authors: Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka, 811-1395, Japan.
authors: Yo-ichi
authors: Y
authors: Yamashita
authors: Eisuke
authors: E
authors: Adachi
authors: Yasushi
authors: Y
authors: Toh
authors: Kippei
authors: K
authors: Ohgaki
authors: Osamu
authors: O
authors: Ikeda
authors: Eiji
authors: E
authors: Oki
authors: Kazuhito
authors: K
authors: Minami
authors: Yoshihisa
authors: Y
authors: Sakaguchi
authors: Eiji
authors: E
authors: Tsujita
authors: Takeshi
authors: T
authors: Okamura
mesh_terms: D017024:Chemotherapy, Adjuvant; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003952:Diagnostic Imaging; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery*; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors