title: Features, predictors and prognosis of lymphoproliferative disorders post-liver transplantation regarding disease presentation time: report from the PTLD.Int. survey.
abstract: BACKGROUND
  The present study deals with different aspects of PTLD in a very large number of liver transplant recipients, whose data recruited from 30 previous reports, with regard to their presentation time.
  
  
  METHODS
  We conducted a comprehensive search for the available data by Pubmed and Google scholar search engines for reports indicating presentation time in PTLD patients. Data from 30 previously published studies were included into analysis. Finally, 231 recipients of liver allograft were included into analysis.
  
  
  RESULTS
  Recipients with early onset PTLD were significantly more likely to represent EBV positive test results (p = 0.0003). Recipients with late onset PTLD represented a significantly higher risk of disseminated disease (p = 0.049). Late onset PTLD more frequently represented monomorphic lesions (p = 0.005). Hodgkin and Hodgkin like diseases also had a trend to occur in the late period after transplantation (p = 0.076), although it did not reach significance level. Liver allograft involvement was more often observed in the early onset PTLD (p < 0.0001), while colon involvement in the late onset disease (p = 0.04). One and five years survival rates for early onset PTLD patients were 64% and 54%, respectively; compared to 73% and 50%, respectively, for the control group (p > 0.1).
  
  
  CONCLUSIONS
  Due to a higher incidence of liver involvement in the early onset PTLD patients and colon involvement in late onset PTLD, authors suggest that liver graft recipients should receive enough evaluations for a potential multi organ disease based on their presentation time. Further multi-institutional prospective studies are needed to confirm our results.
authors: Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. dr.izadi.m@gmail.com
authors: Morteza
authors: M
authors: Izadi
authors: Saeed
authors: S
authors: Taheri
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003625:Data Collection; D020031:Epstein-Barr Virus Infections / Q000209:etiology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016014:Linear Models; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult