title: Does chemotherapy-induced oxidative stress improve the survival rates of breast cancer patients?
abstract: Antineoplastic agents induce oxidative stress leading to lipid, carbohydrate, protein, and DNA damage. We sought to explore the role of drug-induced oxidative stress on breast cancer patient's survival. We observed that neoadjuvant patients presented a marked raise in DNA damage and protein carbonyl levels after chemotherapy, whereas postchemotherapy DNA repair activity of the KU86 enzyme and total antioxidant capacity of the plasma were higher in the adjuvant group. With respect to patient's survival, we observed that increasing levels of KU86 and antioxidant capacity of the plasma during chemotherapy significantly influenced the survival rates of the patients, protecting from disease recurrence and death. Our results suggest that chemotherapy induces a certain level of systemic oxidative stress, which is maintained along successive clinical interventions and could influence the clinical outcome of the patients.
authors: Department of Oncology, Complejo Hospitalario de Jaen, Jaen, Spain. lvera@correo.ugr.es
authors: Laura
authors: L
authors: Vera-Ramirez
authors: Pedro
authors: P
authors: Sanchez-Rovira
authors: M Carmen
authors: MC
authors: Ramirez-Tortosa
authors: Cesar L
authors: CL
authors: Ramirez-Tortosa
authors: Sergio
authors: S
authors: Granados-Principal
authors: Monica
authors: M
authors: Fernandez-Navarro
authors: Jose A
authors: JA
authors: Lorente
authors: Jose L
authors: JL
authors: Quiles
mesh_terms: D000328:Adult; D034961:Antigens, Nuclear / Q000378:metabolism; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D020552:Comet Assay; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D000072200:Ku Autoantigen; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D018384:Oxidative Stress; D051716:Replication Protein A / Q000378:metabolism; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D034961:Antigens, Nuclear; D000970:Antineoplastic Agents; D000975:Antioxidants; D004268:DNA-Binding Proteins; D051716:Replication Protein A; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen