title: Antidiarrhoeal and antiulcer activities of Hippocratea africana root extract.
abstract: The effect of ethanol root extract of H. africana on experimentally induced diarrhoea and ulcer was studied in rodents. The extract (200-600 mg/kg) considerably inhibited castor oil induced diarrhoea, small intestine transit time and castor oil induced fluid accumulation as well as indomethacin and ethanol induced ulcer models. The effect of the extract in these models was comparable to the various standard drugs used. The root extract of H. africana has antidiarrhoeal and antiulcer properties which justify its uses in ethnomedicine.
authors: Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, and Department of Chemical Pathology, University of Uyo Teaching Hospital, Uyo, Nigeria. judeefiom@yahoo.com
authors: Jude Efiom
authors: JE
authors: Okokon
authors: Henry Dan
authors: HD
authors: Akpan
authors: Emem Ekpo
authors: EE
authors: Umoh
authors: Itemobong Sunday
authors: IS
authors: Ekaidem
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000930:Antidiarrheals / Q000494:pharmacology*; D005260:Female; D031320:Hippocrateaceae; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000897:Anti-Ulcer Agents; D000930:Antidiarrheals; D010936:Plant Extracts