title: Exploring airway diseases by NMR-based metabonomics: a review of application to exhaled breath condensate.
abstract: There is increasing evidence that biomarkers of exhaled gases or exhaled breath condensate (EBC) may help in detecting abnormalities in respiratory diseases mirroring increased, oxidative stress, airways inflammation and endothelial dysfunction. Beside the traditional techniques to investigate biomarker profiles, "omics" sciences have raised interest in the clinical field as potentially improving disease phenotyping. In particular, metabonomics appears to be an important tool to gain qualitative and quantitative information on low-molecular weight metabolites present in cells, tissues, and fluids. Here, we review the potential use of EBC as a suitable matrix for metabonomic studies using nuclear magnetic resonance (NMR) spectroscopy. By using this approach in airway diseases, it is now possible to separate specific EBC profiles, with implication in disease phenotyping and personalized therapy.
authors: Department of Respiratory Medicine, AO Monaldi, University of Naples Federico II, Naples, Italy.
authors: Matteo
authors: M
authors: Sofia
authors: Mauro
authors: M
authors: Maniscalco
authors: Guglielmo
authors: G
authors: de Laurentiis
authors: Debora
authors: D
authors: Paris
authors: Dominique
authors: D
authors: Melck
authors: Andrea
authors: A
authors: Motta
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001944:Breath Tests / Q000379:methods*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D055432:Metabolomics / Q000379:methods*; D012140:Respiratory Tract Diseases / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D015415:Biomarkers