title: The Groningen assisted reproductive technologies cohort study: developmental status and behavior at 2 years.
abstract: OBJECTIVE
  To evaluate whether children's cognitive and psychomotor development and behavior at 2 years are affected by ovarian hyperstimulation and the IVF laboratory procedures or subfertility.
  
  
  METHODS
  Prospective longitudinal cohort study.
  
  
  METHODS
  University Medical Center Groningen, the Netherlands.
  
  
  METHODS
  Singletons born after controlled ovarian hyperstimulation (COH)-IVF (n=66) and modified natural cycle-IVF (n=56), singletons born to subfertile couples who conceived naturally (subfertile-naturally conceived, n=87), and a reference group of 101 2-year-old singletons born to fertile couples.
  
  
  METHODS
  None.
  
  
  METHODS
  Bayley Scales of Infant Development and Achenbach Child Behavior Checklist.
  
  
  RESULTS
  Mental and psychomotor development and behavioral outcome in COH-IVF, modified natural cycle-IVF, and subfertile-natural cycle groups was not different. Developmental outcome and behavior of the subfertile groups were largely similar to those of the fertile reference group. Nevertheless, the subfertile groups scored higher on the scale of anxious-depressed behavior than the reference group.
  
  
  CONCLUSIONS
  This present relatively small study found no differences in cognitive and psychomotor development and behavior at 2 years in children born after COH-IVF or modified natural cycle-IVF or naturally conceived children of subfertile parents. Replication of the study is needed before firm conclusions can be drawn. Furthermore, long-term follow-up is needed to confirm these findings in older children.
authors: Department of Pediatrics, Division of Developmental Neurology, University Medical Center Groningen, Groningen, the Netherlands.
authors: Marjolein
authors: M
authors: Jongbloed-Pereboom
authors: Karin J
authors: KJ
authors: Middelburg
authors: Maas Jan
authors: MJ
authors: Heineman
authors: Arend F
authors: AF
authors: Bos
authors: Mijna
authors: M
authors: Hadders-Algra
mesh_terms: D000367:Age Factors; D016022:Case-Control Studies; D057189:Checklist; D016009:Chi-Square Distribution; D002652:Child Behavior; D002657:Child Development; D002675:Child, Preschool; D003071:Cognition; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D009426:Netherlands; D010062:Ovulation Induction; D011446:Prospective Studies; D002666:Psychology, Child; D011597:Psychomotor Performance; D027724:Reproductive Techniques, Assisted