title: Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells.
abstract: Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.
authors: Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, Oklahoma 73019, USA.
authors: P Matthew
authors: PM
authors: Joyner
authors: Amanda L
authors: AL
authors: Waters
authors: Russell B
authors: RB
authors: Williams
authors: Douglas R
authors: DR
authors: Powell
authors: Naveena B
authors: NB
authors: Janakiram
authors: Chinthalapally V
authors: CV
authors: Rao
authors: Robert H
authors: RH
authors: Cichewicz
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001483:Base Sequence; D003110:Colonic Neoplasms; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D004224:Diterpenes; C559168:brialalepolide A; C559169:brialalepolide B; C559170:brialalepolide C