title: Curvature factor and membrane solubilization, with particular reference to membrane rafts.
abstract: The composition of membrane rafts (cholesterol/sphingolipid-rich domains) cannot be fully deduced from the analysis of a detergent-resistant membrane fraction after solubilization in Triton X-100 at 4°C. It is hypothesized that the membrane curvature-dependent lateral distribution of membrane components affects their solubilization. The stomatocytogenic, Triton X-100, cannot effectively solubilize membrane components, especially with regard to the outward membrane curvature.
authors: Department of Cell Biology, A. Mickiewicz University, Pozna, Poland.
authors: Lucyna
authors: L
authors: Mrówczyńska
authors: Ulrich
authors: U
authors: Salzer
authors: Aleš
authors: A
authors: Iglič
authors: Henry
authors: H
authors: Hägerstrand
mesh_terms: D002784:Cholesterol / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D021962:Membrane Microdomains / Q000378:metabolism*; D008962:Models, Theoretical; D017830:Octoxynol / Q000494:pharmacology; D013107:Sphingolipids / Q000737:chemistry
chemical_list: D013107:Sphingolipids; D017830:Octoxynol; D002784:Cholesterol