title: [Dynamic contrast-enhanced MRI of the prostate: comparison of two different post-processing algorithms].
abstract: OBJECTIVE
  To evaluate the usefulness of a commercially available post-processing software tool for detecting prostate cancer on dynamic contrast-enhanced magnetic resonance imaging (MRI) and to compare the results to those obtained with a custom-made post-processing algorithm already tested under clinical conditions.
  
  
  METHODS
  Forty-eight patients with proven prostate cancer were examined by standard MRI supplemented by dynamic contrast-enhanced dual susceptibility contrast (DCE-DSC) MRI prior to prostatectomy. A custom-made post-processing algorithm was used to analyze the MRI data sets and the results were compared to those obtained using a post-processing algorithm from In vivo Corporation (Dyna CAD for Prostate) applied to dynamic T 1-weighted images. Histology was used as the gold standard.
  
  
  RESULTS
  The sensitivity for prostate cancer detection was 78 % for the custom-made algorithm and 60 % for the commercial algorithm and the specificity was 79 % and 82 %, respectively. The accuracy was 79 % for our algorithm and 77.5 % for the commercial software tool. The chi-square test (McNemar-Bowker test) yielded no significant differences between the two tools (p = 0.06).
  
  
  CONCLUSIONS
  The two investigated post-processing algorithms did not differ in terms of prostate cancer detection. The commercially available software tool allows reliable and fast analysis of dynamic contrast-enhanced MRI for the detection of prostate cancer.
authors: Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Mitte. dirk.beyersdorff@charite.de
authors: D
authors: D
authors: Beyersdorff
authors: L
authors: L
authors: Lüdemann
authors: E
authors: E
authors: Dietz
authors: D
authors: D
authors: Galler
authors: P
authors: P
authors: Marchot
authors: T
authors: T
authors: Franiel
mesh_terms: D000368:Aged; D000465:Algorithms; D001810:Blood Volume / Q000502:physiology; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D011467:Prostate / Q000098:blood supply / Q000473:pathology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000175:diagnosis* / Q000601:surgery; D012372:ROC Curve; D012039:Regional Blood Flow / Q000502:physiology; D012680:Sensitivity and Specificity; D012984:Software
chemical_list: D003287:Contrast Media