title: [Characteristics of endometrial carcinoma in obese women].
abstract: BACKGROUND
  In most developed countries, endometrial cancer appears as most frequent invasive neoplasm of genital tract. Obesity is one of most important risk factors. Aim of study was to establish characteristics endometrial cancer in obese women.
  
  
  METHODS
  The study included 50 surgically treated women with endometrial cancer. According body mass index they were divided into two groups--group A (30 obese women), group B (20 non-obese women).
  
  
  CONCLUSIONS
  Non-obese women with endometrial cancer are statistically significantly older than obese. Menopausal status, parity are not statistically significant. The obese group most frequently includes endometrioid type of tumor, while non-obese group most frequently includes non-endometrioid types of endometrial cancer. Over 50% thick myometrial invasion is statistically more frequent in non-obese group than in obese group. In obese group, less than 50% thick myometrial invasion, is statistically significant in comparison to nonobese group. High-differentiated endometrial cancer (G1) is statistically significantly more present in obese women than non-obese. Low-differentiated endometrial cancer is statistically more frequent in non-obese women than in obese. Most frequent in both groups is NG2. According to FIGO stage I, disease is statistically significantly more frequent in obese group than in non-obese. In non-obese group, total number of diseased in higher stages (II and III) is statistically significantly higher than in stage I.
  
  
  CONCLUSIONS
  Endometrial cancer present in obese women is mostly endometroid type I, with slow myometrial invasion, with histological grade I, nuclear grade II in FIGO stage I of disease. In non-obese women, non-endometrioid cancer-- type II is more frequent, with faster myometrial invasion, histological grade II and III, nuclear grade II, in FIGO stage II of disease.
authors: Klinicki centar Nis, Nis. predragvukomanovic@yahoo.com
authors: Predrag
authors: P
authors: Vukomanović
authors: Ranko
authors: R
authors: Kutlesić
authors: Milan
authors: M
authors: Stefanović
authors: Mileva
authors: M
authors: Milosavljević
authors: Jasmina
authors: J
authors: Popović
authors: Aleksandra
authors: A
authors: Petrić
mesh_terms: D000368:Aged; D016889:Endometrial Neoplasms / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000150:complications