title: Abnormalities of DNA repair mechanisms in common hematological malignancies.
abstract: DNA repair is an important defense mechanism that faces the difficult task of protecting the genome from the constant assaults caused by endogenous and exogenous agents. Since DNA repair mechanisms are responsible for correcting DNA damage and preserving genomic integrity, it is obvious that abnormalities of these mechanisms may result in neoplastic transformation. Hematological malignancies are characterized by genomic instability that is possibly related to underlying defects in DNA repair. The purpose of this review is to summarize the existing knowledge concerning abnormalities in DNA repair components and their influence on common hematological malignancies.
authors: Second Department of Internal Medicine, Propaedeutic, University of Athens, Medical School, University General Hospital Attikon, Haidari, Greece. panagiota_oiko@hotmail.com
authors: Panagiota
authors: P
authors: Economopoulou
authors: Vassiliki
authors: V
authors: Pappa
authors: Sotirios
authors: S
authors: Papageorgiou
authors: John
authors: J
authors: Dervenoulas
authors: Theofanis
authors: T
authors: Economopoulos
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D004260:DNA Repair / Q000235:genetics*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D006801:Humans; D000067856:Poly(ADP-ribose) Polymerase Inhibitors
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D000067856:Poly(ADP-ribose) Polymerase Inhibitors