title: Central macular splaying and outer retinal thinning in asymptomatic sickle cell patients by spectral-domain optical coherence tomography.
abstract: OBJECTIVE
  To investigate the prevalence and degree of macular thinning on optical coherence tomography (SDOCT) in African-American female patients with asymptomatic sickle cell disease.
  
  
  METHODS
  Prospective comparative case series.
  
  
  METHODS
  Twenty-one sickle cell patients (42 eyes) without other systemic or ocular diseases and 18 healthy control patients (33 eyes) underwent SD-OCT. Images were manually segmented to measure inner retinal thickness (IRT) and outer retinal thickness (ORT). Central macular (central 1 mm), parafoveal (0.5-1.5 mm eccentricity), and perifoveal (1.5-3 mm eccentricity) thickness measurements were obtained in sickle cell patients and age/gender/race-matched healthy control subjects.
  
  
  RESULTS
  Central macular total thickness (CMT) in sickle cell patients was 220 ± 3 μm (mean ± SEM), which was significantly lower (P < .05) than controls (228 ± 3 μm). Parafoveal regions had thickness measurements of 314 ± 5 μm (nasal) and 304 ± 2 μm (temporal), which were significantly lower than controls (327 ± 2 μm and 311 ± 2 μm nasally and temporally, respectively) (P < .03, P < .043). There was also no significant difference in IRT in central macula, parafoveal, and perifoveal regions. Central macular ORT was 175 ± 2 μm vs 185 ± 1 μm in controls (P < .0002). ORT in temporal parafoveal and perifoveal regions was 142 ± 2 μm and 120 ± 1 μm, respectively, vs 150 ± 1 μm and 122 ± 1 μm in controls (P < .001 and P = .16, respectively).
  
  
  CONCLUSIONS
  Manual segmentation of SD-OCT images revealed significant total retinal thinning in the central macula and splaying in asymptomatic sickle cell patients. Retinal thinning was predominately in outer retinal layers in central macula and parafoveal regions.
authors: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor St., Chicago, IL 60612, USA.
authors: Quan V
authors: QV
authors: Hoang
authors: Felix Y
authors: FY
authors: Chau
authors: Mahnaz
authors: M
authors: Shahidi
authors: Jennifer I
authors: JI
authors: Lim
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000755:Anemia, Sickle Cell / Q000175:diagnosis* / Q000208:ethnology; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D033401:Microscopy, Acoustic; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012164:Retinal Diseases / Q000175:diagnosis* / Q000208:ethnology; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult