title: Hypouricemic effects of anthocyanin extracts of purple sweet potato on potassium oxonate-induced hyperuricemia in mice.
abstract: Gout is a clinical syndrome in which tissue damage is induced by a chronic metabolic disorder associated with increased concentrations of uric acid in the blood. The study investigated the hypouricemic effects of anthocyanin extracts from purple sweet potato (APSP), and allopurinol, on serum uric acid levels in hyperuricemic mice. It was found that administration of a single oral dose of 100 mg/kg APSP to such animals reduced the serum uric acid concentration to 4.10 ± 0.04 mg/dL, compared with a concentration of 10.25 ± 0.63 mg/dL in the hyperuricemic control group.
authors: Bioindustrial Process Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology, Jeonbuk, 580-185, Republic of Korea.
authors: Kwon Sun
authors: KS
authors: Hwa
authors: Dong-Min
authors: DM
authors: Chung
authors: Young Chul
authors: YC
authors: Chung
authors: Hyo Kon
authors: HK
authors: Chun
mesh_terms: D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D004195:Disease Models, Animal; D033461:Hyperuricemia / Q000139:chemically induced / Q000188:drug therapy*; D027723:Ipomoea batatas / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010094:Oxonic Acid; D010936:Plant Extracts / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood
chemical_list: D000872:Anthocyanins; D010936:Plant Extracts; D014527:Uric Acid; C489337:potassium oxonate; D010094:Oxonic Acid; D000493:Allopurinol