title: Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents.
abstract: New indoline alkaloid-type compounds which inhibit HCV production by infected hepatoma cells have been identified. These compounds, dimeric-type compounds of previously known inhibitors, display double digit nanomolar IC(50) and EC(50) values, with cytotoxicity CC(50) indexes higher than 36 μM, thus providing ample therapeutic windows for further development of HCV drugs.
authors: Department of Chemistry and the Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Ave, Boston, MA 02215, United States.
authors: Feng
authors: F
authors: Ni
authors: Smitha
authors: S
authors: Kota
authors: Virginia
authors: V
authors: Takahashi
authors: A Donny
authors: AD
authors: Strosberg
authors: John K
authors: JK
authors: Snyder
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D019281:Dimerization; D016174:Hepacivirus / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000737:chemistry; D014758:Viral Core Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000470:Alkaloids; D000998:Antiviral Agents; D007211:Indoles; D014758:Viral Core Proteins; C069130:nucleocapsid protein, Hepatitis C virus; C057812:indoline