title: Salicylic acid-derived poly(anhydride-ester) electrospun fibers designed for regenerating the peripheral nervous system.
abstract: Continuous biomaterial advances and the regenerating potential of the adult human peripheral nervous system offer great promise for restoring full function to innervated tissue following traumatic injury via synthetic nerve guidance conduits (NGCs). To most effectively facilitate nerve regeneration, a tissue engineering scaffold within a conduit must be similar to the linear microenvironment of the healthy nerve. To mimic the native nerve structure, aligned poly(lactic-co-glycolic acid)/bioactive polyanhydride fibrous substrates were fabricated through optimized electrospinning parameters with diameters of 600 ± 200 nm. Scanning electron microscopy images show fibers with a high degree of alignment. Schwann cells and dissociated rat dorsal root ganglia demonstrated elongated and healthy proliferation in a direction parallel to orientated electrospun fibers with significantly longer Schwann cell process length and neurite outgrowth when compared to randomly orientated fibers. Results suggest that an aligned polyanhydride fiber mat holds tremendous promise as a supplement scaffold for the interior of a degradable polymer NGC. Bioactive salicylic acid-based polyanhydride fibers are not limited to nerve regeneration and offer exciting promise for a wide variety of biomedical applications.
authors: Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08854, USA.
authors: Jeremy
authors: J
authors: Griffin
authors: Roberto
authors: R
authors: Delgado-Rivera
authors: Sally
authors: S
authors: Meiners
authors: Kathryn E
authors: KE
authors: Uhrich
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005727:Ganglia, Spinal / Q000502:physiology; D048091:Guided Tissue Regeneration / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry; D051379:Mice; D009416:Nerve Regeneration / Q000187:drug effects*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D020156:Salicylic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D012583:Schwann Cells / Q000166:cytology; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D020156:Salicylic Acid