title: The combination of resveratrol and conjugated linoleic acid is not useful in preventing obesity.
abstract: Scientific research is constantly looking for new molecules to be used as functional ingredients to combat obesity. The aim of the present study was to analyse whether resveratrol and conjugated linoleic acid (CLA) together could reduce body fat more efficiently than their separate administration. Thirty-six male Wistar rats were randomly divided into four groups: controls rats (C), rats treated with resveratrol (RSV), rats treated with CLA (CLA) and rats treated with a combination of resveratrol and CLA (RSV+CLA). All rats were fed on an obesogenic diet. In RSV and RSV+CLA groups, the rats received 30 mg resveratrol/kg body weight/day. In CLA and RSV+CLA groups, an equimolecular mixture of trans-10,cis-12 and cis-9,trans-11 was added to the diet to reach 0.5% of the active isomer trans-10,cis-12. After 6 weeks of treatment, white adipose tissue from different anatomical locations was dissected and weighed. Serum triacylglycerols, total and HDL cholesterols, glucose, insulin, fructosamine and TNF-α were measured. A glucose tolerance test was also performed. Separately, resveratrol and CLA significantly reduced body fat but did not do so when combined: 20% in the RSV group and 18% in CLA group but 7% in the RSV+CLA group. Resveratrol reduced serum triacylglycerols. No differences were found among groups in serum cholesterol. Resveratrol, as well as the combination RSV+CLA, improved glycaemic control. These results demonstrate that the combination RSV+CLA reduces the effectiveness of each compound on body fat-lowering action, but it maintains the positive effect of resveratrol on glycaemic control. Consequently, this combination has no usefulness in obesity prevention.
authors: Department of Nutrition and Food Science, Faculty of Pharmacy, University of País Vasco, Paseo de la Universidad 7, Vitoria, Spain.
authors: Noemi
authors: N
authors: Arias
authors: Maria Teresa
authors: MT
authors: Macarulla
authors: Leixuri
authors: L
authors: Aguirre
authors: María Guadalupe
authors: MG
authors: Martínez-Castaño
authors: Saioa
authors: S
authors: Gómez-Zorita
authors: Jonatan
authors: J
authors: Miranda
authors: José Alfredo
authors: JA
authors: Martínez
authors: María Puy
authors: MP
authors: Portillo
mesh_terms: D052436:Adipose Tissue, White / Q000378:metabolism / Q000473:pathology; D000818:Animals; D019540:Area Under Curve; D001786:Blood Glucose; D001835:Body Weight / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D002149:Energy Intake / Q000187:drug effects; D005951:Glucose Tolerance Test; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000517:prevention & control*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D017211:Treatment Failure
chemical_list: D001786:Blood Glucose; D044243:Linoleic Acids, Conjugated; D008055:Lipids; D013267:Stilbenes; D000077185:Resveratrol