title: Plasma apo/lipoproteins disturbances as a precondition for metabolic syndrome in HCV seronegative heroin addicts.
abstract: BACKGROUND
  Dyslipidemia in heroin addicts is considered to be a precondition for developing metabolic syndrome.
  
  
  OBJECTIVE
  The aim was to evaluate the frequency in serum lipid disturbances of hepatitis C virus (HCV) seronegative heroin addicts; the capacity of high-density lipoprotein (HDL)-C and apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) for predicting hypertriglyceridemia/low HDL-C profile; correlation of HDL-C with the apoB/apoA-I and their correlation to plasma apo/lipoproteins.
  
  
  METHODS
  Sixty-six heroin addicts, seronegative for HCV and HIV, without liver morphological changes were divided into two groups according to their decreased/normal HDL-C concentrations.
  
  
  RESULTS
  We registered decreased HDL-C in 58.8% of the addicts; decreased apoA-I in 50.9%, increased triglyceride (TGL) in 35.9%, and increased apoB/apoA-I in 3.8% of the patients; and 25.7% had hypertriglyceridemia/low HDL profile. Addicts with low HDL-C had higher TGL (1.73 ± .91 vs. 1.31 ± .71, pр = .02) compared with addicts with normal HDL-C and the controls. Low HDL-C group had higher apoB/apoA-I compared with addicts with normal HDL-C (.62 ± .28 vs. .42 ± .11, pр = .000). HDL-C inversely correlated to apoB/apoA-I (p = -.452, pр = .001). ApoB/apoA-I showed stronger correlation with the observed apo/lipoproteins than the HDL-C. The logistic regression model showed that apoB/apoA-I index (OR 89.1, 95% CI 1.3-5971.2) is more significant predictor in developing hypertriglyceridemia/low HDL profile than HDL-C.
  
  
  CONCLUSIONS
  Heroin addiction is associated with decreased plasma concentrations of HDL-C, apoA-I, apoB, and increased TGL concentrations. In heroin addicts, HDL-C concentrations are significantly associated with the apoB/apoA-I index, which correlates to all lipid fractions and is a stronger predictor of metabolic syndrome lipid profile in heroin addicts.
authors: University Clinic of Toxicology, Skopje, The Former Yugoslav Republic of Macedonia. perevska@yahoo.com
authors: Zanina Jovan
authors: ZJ
authors: Pereska
authors: Cvetanka
authors: C
authors: Bozinovska
authors: Cedomir
authors: C
authors: Dimitrovski
authors: Lidija
authors: L
authors: Petkovska
authors: Andon
authors: A
authors: Cibisev
authors: Irena
authors: I
authors: Jurukov
mesh_terms: D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D016174:Hepacivirus; D006515:Hepatitis B virus; D006556:Heroin Dependence / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D001053:Apolipoproteins; D008076:Cholesterol, HDL; D014280:Triglycerides