title: Endocannabinoid system protects against cryptogenic seizures.
abstract: Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5-8 days. We hypothesize that an accumulation of micro-injuries in the brain is responsible for these "spontaneous" seizures.
authors: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, P.O.B. 9104, 6500 HE Nijmegen, The Netherlands. t.vanrijn@donders.ru.nl
authors: Clementina M
authors: CM
authors: van Rijn
authors: Martin F J
authors: MF
authors: Perescis
authors: Lyudmila
authors: L
authors: Vinogradova
authors: Gilles
authors: G
authors: van Luijtelaar
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004569:Electroencephalography; D063388:Endocannabinoids; D005260:Female; D010880:Piperidines / Q000008:administration & dosage / Q000633:toxicity*; D011720:Pyrazoles / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors*; D000077285:Rimonabant; D012640:Seizures / Q000139:chemically induced*; D013997:Time Factors
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D010880:Piperidines; D011720:Pyrazoles; D043884:Receptor, Cannabinoid, CB1; D000077285:Rimonabant