title: [Effect of baicalin on pharmacokinetics of chlorogenic acid in rabbits].
abstract: OBJECTIVE
  The objective of this paper is to investigate the pharmacokinetics of Chlorogenic acid (CA)and CA-Baicalin compound after intravenous injection (iv) in rabbits.
  
  
  METHODS
  Ten rabbits were randomly divided into two groups. One group were administered CA (6 mg x kg(-1)) by iv, while the other were treated with CA (6 mg x kg(-1))-baicalin (90 mg x kg(-1)) compound by iv. administration. The concentration of CA in plasma was determined by HPLC. The key parameters of pharmacokinetics were calculated and analyzed by kinetic software.
  
  
  RESULTS
  Both Concentration-time courses of CA alone and CA-Baicalin compound were consistent with a two-compartment model after administration. The key pharmacokinetic parameters of CA alone were significantly different from that of CA-Baicalin compound (P < 0.05). Compared with the group treated with CA alone, the group treated with CA-Baicalin compound had dramatic increased in AUC(0-infinity), MRT and T1/2alpha.
  
  
  CONCLUSIONS
  There are significant difference between the pharmacokinetics of CA and CA-Baicalin compound in rabbits. Baicalin has impact on the pharmacokinetics of CA in rabbits.
authors: School of Chinese Materia Medica, Beijing university of Chinese medicine, Beijing 100102, China. gmacli@sohu.com
authors: Zhaoxi
authors: Z
authors: Li
authors: Jian
authors: J
authors: Ni
authors: Guannan
authors: G
authors: Fang
authors: Yeli
authors: Y
authors: Gao
authors: Jia
authors: J
authors: Wei
mesh_terms: D000818:Animals; D002138:Calibration; D002726:Chlorogenic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005419:Flavonoids / Q000494:pharmacology*; D007275:Injections, Intravenous; D016014:Linear Models; D008297:Male; D011817:Rabbits; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D005419:Flavonoids; D002726:Chlorogenic Acid; C038044:baicalin