title: [Conventional in vitro fertilization and intracytoplasmic sperm injection in sibling oocytes following intrauterine inseminations failure].
abstract: OBJECTIVE
  To evaluate the results of the initial in vitro fertilization (IVF) procedure after intrauterine insemination (IUI) failure where half of the oocytes were inseminated as for conventional IVF and half of the oocytes where treated for intra cytoplasmic sperm injection (ICSI).
  
  
  METHODS
  From the first of January 2001 to the 31st of December 2008, 75 couples failing to conceive with ovarian stimulation and IUI were included in this retrospective study.
  
  
  RESULTS
  Among the 75 couples, 53 had IVF and ICSI in sibling oocytes and 22 had just ICSI because of an insufficient oocyte cohort. No significant difference was observed in fertilization, implantation and pregnancy rates between the different groups; however, a total fertilization failure was observed more frequently when conventional IVF was used compared to ICSI (11.3% vs 3.8%). These patients with fertilization failure on conventional IVF had a lower sperm count than those who obtained embryos but sperm parameters were normal according to World Health Organisation (WHO) criteria and our study did not find any predictive factor of fertilization failure.
  
  
  CONCLUSIONS
  Couples failing to conceive after controlled ovarian hyperstimulation and IUI may be proposed a mixed in vitro fertilization procedure (with conventional IVF and ICSI) in order to avoid a total fertilization failure. Moreover, this procedure will indicate the better IVF technology (conventional or ICSI) for the subsequent attempt.
authors: Service de gyne´cologie-obste´trique, pavillon me`re et enfant, CHU Charles-Nicolle, Rouen cedex, France. veronika_gre@yahoo.fr
authors: V
authors: V
authors: Grzegorczyk
authors: A
authors: A
authors: Perdrix
authors: B
authors: B
authors: Clavier
authors: N
authors: N
authors: Mousset-Siméon
authors: N
authors: N
authors: Rives
authors: L
authors: L
authors: Marpeau
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D009865:Oocytes; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D016896:Treatment Outcome