title: Complete atrioventricular block-induced Torsade de pointes, manifested by epilepsy.
abstract: Complete atrioventricular (AV) block is frequently regarded as a cause of informed syncopal attacks, even though the escape rhythm is maintained. Torsade de pointes (TdP) may be a significant complication of AV block associated with QT prolongation. Here, we report the case of a 42-year-old female who was referred to our hospital due to recurrent seizure-like attacks while taking anti-convulsant drugs at a psychiatric hospital. TdP with a long QT interval (corrected QT = 0.591 seconds) was observed on an electrocardiogram (ECG) taken in the emergency department. The patient's drug history revealed olanzapine as the suspicious agent. Even after the medication was stopped, however, the QT interval remained within an abnormal range and multiple episodes of TdP and related seizure-like symptoms were found via ECG monitoring. A permanent pacemaker was thus implanted, and the ventricular rate was set at over 80 beats/min. There was no recurrence of tachyarrhythmia or other symptoms.
authors: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea School of Medicine, Daejeon, Korea.
authors: Jun Han
authors: JH
authors: Jeon
authors: Sung Ho
authors: SH
authors: Her
authors: Jung Yeon
authors: JY
authors: Chin
authors: Ki Hoon
authors: KH
authors: Park
authors: Hee Jeong
authors: HJ
authors: Yoon
authors: Jong Min
authors: JM
authors: Lee
authors: Seung Won
authors: SW
authors: Jin
mesh_terms: D000328:Adult; D054537:Atrioventricular Block / Q000150:complications*; D001569:Benzodiazepines / Q000009:adverse effects; D004562:Electrocardiography; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D006801:Humans; D000077152:Olanzapine; D010138:Pacemaker, Artificial; D016171:Torsades de Pointes / Q000209:etiology* / Q000628:therapy
chemical_list: D001569:Benzodiazepines; D000077152:Olanzapine