title: Therapeutic potential of peroxisome proliferator-activated receptor γ agonist rosiglitazone in cerebral vasospasm after a rat experimental subarachnoid hemorrhage model.
abstract: The pathogenesis of cerebral vasospasm is closely associated with inflammation and immune response in arterial walls. Recently, the authors proved the key role of Toll-like receptor (TLR)4 in the development of vasospasm in experimental subarachnoid hemorrhage (SAH) model. Because peroxisome proliferator-activated receptor (PPAR) gamma agonists are identified as effective inhibitors of TLR4 activation, we investigated the anti-inflammation properties of PPAR-gamma agonist rosiglitazone in basilar arteries in a rat experimental SAH model and evaluated the effects of rosiglitazone on vasospasm. Inflammatory responses in basilar arteries were assessed by immunohistochemical staining for intercellular molecule (ICAM)-1 and myeloperoxidase (MPO). Expression of TLR4 was determined by western blot analysis. The degree of cerebral vasospasm was evaluated by measuring the mean diameter and cross-sectional area of basilar arteries. Rosiglitazone suppressed the SAH-induced inflammatory responses in basilar arteries by inhibiting the TLR4 signalling. Furthermore, rosiglitazone could attenuate cerebral vasospasm following SAH. Therefore, we suggested that PPAR-gamma agonists may be potential therapeutic agents for cerebral vasospasm.
authors: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China.
authors: Yi
authors: Y
authors: Wu
authors: Ke
authors: K
authors: Tang
authors: Ren-Qiang
authors: RQ
authors: Huang
authors: Zong
authors: Z
authors: Zhuang
authors: Hui-Lin
authors: HL
authors: Cheng
authors: Hong-Xia
authors: HX
authors: Yin
authors: Ji-Xin
authors: JX
authors: Shi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D047495:PPAR gamma / Q000819:agonists* / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077154:Rosiglitazone; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D045162:Thiazolidinediones / Q000627:therapeutic use*; D051197:Toll-Like Receptor 4 / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology; D014665:Vasodilator Agents / Q000627:therapeutic use*; D020301:Vasospasm, Intracranial / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*
chemical_list: D047495:PPAR gamma; D045162:Thiazolidinediones; C495347:Tlr4 protein, rat; D051197:Toll-Like Receptor 4; D014665:Vasodilator Agents; D000077154:Rosiglitazone