title: [Pharmacokinetic and dosimetric characteristics of new radiopharmaceutical based on complexes of 103Pd and albumin microspheres].
abstract: Results of the study of absorbed dose formed in organs and tissues of mice after administration of new therapeutic radiopharmaceutical on the base of 103Pd and albumin microspheres (MSA) are presented. Pharmacokinetic parameters of preparation distribution in the body of animals were experimentally determined and then absorbed doses were calculated using MCNP code for the developed mathematical model of mouse. It was shown that absorption of 103Pd-MSA in tumor, physical properties of 103Pd and daughter radionuclide 103mRh provide a targeted irradiation of tumor as compared with the adjusting tissues and critical organs. In administration to tumor muscle tissue of the leg of experimental animals after 15 days following the injection of 103Pd-MSA the accumulated absorbed dose was 15 times less than corresponding one in tumor. In a critical organ (kidneys) the accumulated absorbed dose was 20 times less than in tumor. The work performed as a stage of pre-clinical testing of the radiopharmaceutical.
authors: V G
authors: VG
authors: Skvortsov
authors: V F
authors: VF
authors: Stepanenko
authors: V M
authors: VM
authors: Petriev
authors: M Iu
authors: MIu
authors: Orlov
authors: I G
authors: IG
authors: Kriukova
authors: V A
authors: VA
authors: Sokolov
authors: N B
authors: NB
authors: Borysheva
authors: V K
authors: VK
authors: Shiriaeva
authors: S P
authors: SP
authors: Orlenko
authors: A M
authors: AM
authors: Khaĭlov
authors: A F
authors: AF
authors: Tsyb
mesh_terms: D000418:Albumins / Q000008:administration & dosage*; D000818:Animals; D001918:Brachytherapy / Q000379:methods; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism* / Q000532:radiotherapy; D045744:Cell Line, Tumor; D005260:Female; D051379:Mice; D008863:Microspheres; D009368:Neoplasm Transplantation; D010165:Palladium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011829:Radiation Dosage; D011868:Radioisotopes; D011879:Radiotherapy Dosage; D014018:Tissue Distribution
chemical_list: D000418:Albumins; D011868:Radioisotopes; D010165:Palladium