title: Functional dyspepsia impairs quality of life in the adult population.
abstract: BACKGROUND
  Data on the impact of functional dyspepsia on health-related quality of life in the general adult population are scarce.
  
  
  OBJECTIVE
  To explore the impact of functional dyspepsia applying the Rome III definition on health-related quality of life in the general population.
  
  
  METHODS
  A random sample of an adult Swedish population (n=1001, The Kalixanda study) was invited to undergo an oesophagogastroduodenoscopy. An extended abdominal symptom questionnaire and Short Form-36 (SF-36) questionnaire, which includes eight domains measuring physical, mental and social aspects of quality of life, were completed at the clinic visit just before oesophagogastroduodenoscopy.
  
  
  RESULTS
  Two hundred and two (20%) individuals reported uninvestigated dyspepsia (UID), 157 (16%) functional dyspepsia (FD), 52 (5%) epigastric pain syndrome (EPS) and 122 (12%) postprandial distress syndrome (PDS). UID, FD and PDS had a clinically meaningful (a ≥ 5 point) and statistically significant impact (P<0.05) on health-related quality of life in all SF-36 domains except for Role Emotional. EPS had a significant impact on Bodily Pain and Vitality. Overlap of FD with irritable bowel syndrome (IBS) had a significant impact on Bodily Pain (P=0.002) and General Health (P=0.02) while FD overlap with gastro-oesophageal reflux symptoms (GERS) had a significant impact on Bodily Pain (P=0.02) compared with FD without any overlap with IBS or GERS.
  
  
  CONCLUSIONS
  Functional dyspepsia impacts all main domains describing physical, mental and social aspects of health-related quality of life in the general population. Overlap of functional dyspepsia with irritable bowel syndrome or gastro-oesophageal reflux symptoms impacts the domain related to bodily pain.
authors: Center for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden. pertti.aro@fimnet.fi
authors: P
authors: P
authors: Aro
authors: N J
authors: NJ
authors: Talley
authors: L
authors: L
authors: Agréus
authors: S-E
authors: SE
authors: Johansson
authors: E
authors: E
authors: Bolling-Sternevald
authors: T
authors: T
authors: Storskrubb
authors: J
authors: J
authors: Ronkainen
mesh_terms: D000328:Adult; D000368:Aged; D004415:Dyspepsia / Q000453:epidemiology / Q000523:psychology*; D016145:Endoscopy, Digestive System / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013548:Sweden; D055815:Young Adult