title: T2D-nephropathy linkage within 12q24 locus.
abstract: The 12q24 locus is linked to microcirculation pathology and type 2 diabetes (T2D) with nephropathy and entails the PSMD9 gene linked to T2D. We tested the PSMD9 T2D risk SNPs IVS3+nt460A>G, IVS3+nt437T>C and E197G for linkage to T2D-diabetic nephropathy in 200 Italians T2D families and show linkage to diabetic nephropathy.
authors: Laboratory of Molecular Genetics of Complex and Monogenic Disorders, Department of Medicine and Cellular & Molecular Physiology and Biostatistics, H044, MS Hershey Medical Center, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA. claudia.gragnoli@gmail.com
authors: Claudia
authors: C
authors: Gragnoli
mesh_terms: D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D003928:Diabetic Nephropathies / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D046988:Proteasome Endopeptidase Complex / Q000235:genetics
chemical_list: C114476:PSMD9 protein, human; D046988:Proteasome Endopeptidase Complex