title: The effect of autologous serum eye drops on the conjunctivalization over exposed porous polyethylene orbital implant (Medpor(®)) in the rabbit model.
abstract: OBJECTIVE
  To assess the efficacy of autologous serum eye drops (AS) in enhancing conjunctivalization over a scleral patch graft on exposed porous polyethylene orbital implant (Medpor(®)).
  
  
  METHODS
  Eighteen rabbits were underwent evisceration, implantation of Medpor(®) and homologous scleral patch graft. The conjunctival edge was sutured leaving 5 mm-diameter circular defect. In group A, 20% AS were applied 8 times a day and only balanced salt solution was applied in group B. Digital anterior segment photography was obtained 1, 3, 7, 10, 14, and 21 days after surgery and analyzed with Image Pro Plus(®) software.
  
  
  RESULTS
  In the early postoperative period, the average conjunctival growth rate (mm(2)/day) was faster in group A, but failed to show statistical significance (3.79 vs. 3.03, p = 0.26 in 1~3days, 2.39 vs. 1.80, p = 0.59 in 4- days, 0.03 vs. -0.02, p = 0.94 in 7-10 days, Mann-Whitney test). The complete healing rate was higher (67% vs. 56%, p = 0.5, Fisher's exact test) and the mean elapsed time for complete healing (days) was shorter in group A (17.3 vs. 18.2, p  = 0.83, Mann-Whitney test), but did not show a statistically significant difference.
  
  
  CONCLUSIONS
  In a rabbit model, 20% AS did not appear to facilitate the healing of small conjunctival defects of exposed porous orbital implant.
authors: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors: Joo Hoon
authors: JH
authors: Kim
authors: Ho Kyung
authors: HK
authors: Chung
authors: Nam Ju
authors: NJ
authors: Kim
authors: Min Joung
authors: MJ
authors: Lee
authors: Sang In
authors: SI
authors: Khwarg
mesh_terms: D000085:Acetates / Q000008:administration & dosage; D000818:Animals; D003228:Conjunctiva / Q000254:growth & development*; D004195:Disease Models, Animal; D004338:Drug Combinations; D004848:Epithelium / Q000254:growth & development; D017234:Eye Evisceration; D008903:Minerals / Q000008:administration & dosage; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D020273:Orbital Implants; D011095:Polyethylenes; D011817:Rabbits; D012590:Sclera / Q000637:transplantation; D044967:Serum; D012965:Sodium Chloride / Q000008:administration & dosage; D013529:Surgical Wound Dehiscence / Q000188:drug therapy; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000085:Acetates; C030660:BSS solution; D004338:Drug Combinations; C084562:Medpor; D008903:Minerals; D009883:Ophthalmic Solutions; D011095:Polyethylenes; D012965:Sodium Chloride