title: Facing up to the imperceptible perspiration. Modulatory influences by diabetic neuropathy, physical exercise and antiperspirant.
abstract: BACKGROUND
  Sweating is variably altered by physical exercise, diabetic neuropathy and antiperspirants.
  
  
  METHODS
  Skin temperature, skin surface water loss (SSWL), the Corneometer(®) average capacitance (CMAC) and skin capacitance mapping (SCM) were measured before and after moderate physical exercise in 20 healthy subjects. The effect of 5% aluminium chloride hexahydrate (ACH) in a water solution was similarly tested. The same assessments were performed in 20 diabetic patients at rest.
  
  
  RESULTS
  Diabetic neuropathy appeared at rest as an increased (compensatory) SCM on the forearms without obvious modification on the hypohidrotic legs. On ACH sites after exercise, SCM revealed both a lowered number of active sweat glands and a lighter stratum corneum (SC) (dryness). In addition, CMAC and SSWL were decreased on ACH sites at rest and at completion of exercise.
  
  
  CONCLUSIONS
  In diabetic neuropathy, the compensatory hyperhidrosis is more easily disclosed than the hypohidrosis. ACH affects both sweat excretion and the SC hydration.
authors: Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liège, Liège, Belgium.
authors: Emmanuelle
authors: E
authors: Xhauflaire-Uhoda
authors: Géraldine
authors: G
authors: Mayeux
authors: Pascale
authors: P
authors: Quatresooz
authors: André
authors: A
authors: Scheen
authors: Gérald E
authors: GE
authors: Piérard
mesh_terms: D000328:Adult; D051520:Antiperspirants / Q000627:therapeutic use*; D001834:Body Water / Q000378:metabolism; D046169:Dermoscopy; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy / Q000503:physiopathology*; D007007:Hypohidrosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012879:Skin Physiological Phenomena; D012881:Skin Temperature / Q000502:physiology; D013545:Sweat Glands / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D013546:Sweating / Q000187:drug effects / Q000502:physiology*; D055815:Young Adult
chemical_list: D051520:Antiperspirants