title: Comparative study of liver cancer patients in arsenic exposed and non-exposed areas of Pakistan.
abstract: The investigated data shows that arsenic (As) in drinking water is associated with increased mortality from different types of cancers including liver cancer. In this study, blood and scalp hair samples of male liver cancer patients and healthy referents belonging to As exposed areas of Sindh Pakistan were analyzed for As contents. The As levels in drinking water of understudy area showed that sections of this population was exposed to 3-15-folds higher concentrations of As than permissible limit. For comparative purposes, blood and scalp hair samples of matched cancerous patient as referent patients belonging to big city (Hyderabad) who have used municipal treated water with low As levels <10 μg/L were also collected. The results of this study showed that the average As concentration was higher in the blood and scalp hair of exposed and non-exposed referent cancer patients as compared to referents (p < 001). The exposed cancerous patients have twofolds higher As level in both biological samples as related to non-exposed case matched cancerous male subjects.
authors: National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan. wadhwashamkumar@yahoo.com
authors: Sham Kumar
authors: SK
authors: Wadhwa
authors: Tasneem Gul
authors: TG
authors: Kazi
authors: Akhtar Ali
authors: AA
authors: Chandio
authors: Hassan Imran
authors: HI
authors: Afridi
authors: Nida Fatima
authors: NF
authors: Kolachi
authors: Sumaira
authors: S
authors: Khan
authors: Ghulam Abbas
authors: GA
authors: Kandhro
authors: Syeda
authors: S
authors: Nasreen
authors: Abdul Qadir
authors: AQ
authors: Shah
authors: Jameel Ahmed
authors: JA
authors: Baig
mesh_terms: D000328:Adult; D000368:Aged; D001151:Arsenic / Q000009:adverse effects* / Q000032:analysis / Q000097:blood; D002138:Calibration; D060766:Drinking Water / Q000032:analysis; D004781:Environmental Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data*; D006197:Hair / Q000737:chemistry; D006801:Humans; D007202:Indicators and Reagents; D008113:Liver Neoplasms / Q000453:epidemiology*; D008297:Male; D008452:Maximum Allowable Concentration; D008872:Microwaves; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D013054:Spectrophotometry, Atomic; D014874:Water Pollutants, Chemical; D014881:Water Supply / Q000032:analysis
chemical_list: D060766:Drinking Water; D007202:Indicators and Reagents; D014874:Water Pollutants, Chemical; D001151:Arsenic