title: Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease?
abstract: Seemingly contrasting genetic backgrounds in anti-citrullinated-protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) support the notion that these are in fact two distinct disease subsets, with different underlying pathogenesis, that might need tailored treatment strategies.
authors: Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333ZA, The Netherlands. n.a.daha@lumc.nl
authors: Nina A
authors: NA
authors: Daha
authors: Rene E M
authors: RE
authors: Toes
mesh_terms: D001172:Arthritis, Rheumatoid / Q000145:classification / Q000235:genetics* / Q000276:immunology; D001323:Autoantibodies / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D010456:Peptides, Cyclic / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide