title: Onlay and inlay bone grafts with platelet-rich plasma: histologic evaluations from human biopsies.
abstract: OBJECTIVE
  The aim of the present study was to histomorphometrically evaluate biopsies from 1) sinus inlay bone grafts prepared with or without platelet-rich plasma (PRP) and 2) onlay bone grafts in the anterior maxilla with particulate bone and PRP or block bone without PRP after 3 months.
  
  
  METHODS
  Biopsies were retrieved with a trephine drill, and samples were processed in laboratories to result in nondecalcified cut and ground sections. Light microscopic measurements of total bone area, new bone, number of vessels, and vessel area were performed at 3 regions in each sample. Calculations of ratios of new bone to total bone and vessel area to total area were performed.
  
  
  RESULTS
  There was a tendency toward higher mean values for total bone area percentage and area of newly formed bone in the PRP-treated inlay biopsies. However, there was no measurable effect on vessel formation in the PRP-treated inlay samples compared with untreated inlay samples. Particulate and PRP-treated onlay bone biopsies showed higher mean values in all measured parameters compared with block bone samples; however, no differences were statistically significant.
  
  
  CONCLUSIONS
  PRP treatment may favor bone formation in grafted bone, and further research is needed to describe the outcome of PRP treatment and grafting techniques in the maxilla.
authors: Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
authors: Victoria Franke
authors: VF
authors: Stenport
authors: Anders
authors: A
authors: Örtorp
authors: Andreas
authors: A
authors: Thor
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery; D000540:Alveolar Ridge Augmentation / Q000379:methods; D001706:Biopsy; D001808:Blood Vessels / Q000473:pathology; D016025:Bone Transplantation / Q000379:methods* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008437:Maxilla / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D008443:Maxillary Sinus / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D018919:Neovascularization, Physiologic / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D053657:Platelet-Rich Plasma; D016896:Treatment Outcome