title: [Possible role of nitric oxide in newborns weight gain disorder caused by prolonged dexamethasone therapy (experimental study)].
abstract: Experimental studies on rats revealed that the newborns growth retardation, caused by long-term treatment with Dexamethasone in the neonatal period, can be prevented by the simultaneous with dexamethasone administration of the nitric oxide donor--L-arginine. This indicates that the mentioned Dexamethasone-induced growth disorder is caused by inhibition of Nitric Oxide Synthases activity.
authors: O D
authors: OD
authors: Sinauridze
authors: N V
authors: NV
authors: Gongadze
authors: I D
authors: ID
authors: Kvachadze
authors: G L
authors: GL
authors: Bekaia
mesh_terms: D000818:Animals; D001120:Arginine / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000008:administration & dosage; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D003907:Dexamethasone; D001120:Arginine; D019001:Nitric Oxide Synthase