title: Trends of hematopoietic stem cell transplantation in the Eastern Mediterranean region, 1984-2007.
abstract: Hematopoietic stem cell transplantation (HSCT) activity was surveyed in the 9 countries in the World Health Organization Eastern Mediterranean region that reported transplantation activity. Between the years of 1984 and 2007, 7933 transplantations were performed. The number of HSCTs per year has continued to increase, with a plateau in allogeneic HSCT (allo-HSCT) between 2005 and 2007. Overall, a greater proportion of transplantations were allo-HSCT (n = 5761, 77%) compared with autologous HSCT (ASCT) (n = 2172, 23%). Of 5761 allo-HSCT, acute leukemia constituted the main indication (n = 2124, 37%). There was a significant proportion of allo-HSCT for bone marrow failures (n = 1001, 17%) and hemoglobinopathies (n = 885, 15%). The rate of unrelated donor transplantations remained low, with only 2 matched unrelated donor allo-HSCTs reported. One hundred umbilical cord blood transplantations were reported (0.017% of allo-HSCT). Peripheral blood stem cells were the main source of graft in allo-HSCT, and peripheral blood stem cells increasingly constitute the main source of hematopoietic stem cells overall. Reduced-intensity conditioning was utilized in 5.7% of allografts over the surveyed period. ASCT numbers continue to increase. There has been a shift in the indication for ASCT from acute leukemia to lymphoproliferative disorders (45%), followed by myeloma (26%). The survey reflects transplantation activity according to the unique health settings of this region. Notable differences in transplantation practices as reported to the European Group for Blood and Marrow Transplantation over recent years are highlighted.
authors: King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors: Syed O A
authors: SO
authors: Ahmed
authors: Ardeshir
authors: A
authors: Ghavamzadeh
authors: Syed Z
authors: SZ
authors: Zaidi
authors: Helen
authors: H
authors: Baldomero
authors: Marcelo C
authors: MC
authors: Pasquini
authors: Fazal
authors: F
authors: Hussain
authors: Kamran
authors: K
authors: Alimoghaddam
authors: Fahad
authors: F
authors: Almohareb
authors: Mouhab
authors: M
authors: Ayas
authors: Amir
authors: A
authors: Hamidieh
authors: Hossam K
authors: HK
authors: Mahmoud
authors: Alaa
authors: A
authors: Elhaddad
authors: Tarek
authors: T
authors: Ben Othman
authors: Abdelrahman
authors: A
authors: Abdelkefi
authors: Mahmoud
authors: M
authors: Sarhan
authors: Fawzi
authors: F
authors: Abdel-Rahman
authors: Salman
authors: S
authors: Adil
authors: Salam
authors: S
authors: Alkindi
authors: Ali
authors: A
authors: Bazarbachi
authors: Said
authors: S
authors: Benchekroun
authors: Dietger
authors: D
authors: Niederwieser
authors: Mary
authors: M
authors: Horowitz
authors: Alois
authors: A
authors: Gratwohl
authors: Hassan
authors: H
authors: El Solh
authors: Mahmoud
authors: M
authors: Aljurf
mesh_terms: D001855:Bone Marrow Diseases / Q000628:therapy; D003625:Data Collection; D016208:Databases, Factual; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data* / Q000639:trends; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000628:therapy; D019083:Mediterranean Region; D013997:Time Factors; D019172:Transplantation Conditioning / Q000379:methods / Q000706:statistics & numerical data; D014182:Transplantation, Autologous / Q000706:statistics & numerical data; D014184:Transplantation, Homologous / Q000706:statistics & numerical data