title: Circulating retinol-binding protein 4 and metabolic syndrome in the elderly.
abstract: BACKGROUND
  Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance. Plasma RBP4 concentration may be under the influence of age and obesity, but only a few studies has investigated this link in elderly individuals. Consequently, we tested the correlation between RBP4 concentrations and type 2 diabetes/metabolic syndrome (MetS) components in a large population based cohort study (VITA) of elderly [1, 2]. Using a single birth cohort, this investigation could exclude the influence of age.
  
  
  METHODS
  We evaluated the correlation of RBP4 with type 2 diabetes and MetS components including Body Mass Index (BMI), blood pressure, lipid parameters, fasting glucose insulin, homeostasis model assessment insulin resistance (HOMA-IR), and smoking in exclusively 75-76 year old participants (N = 232).
  
  
  RESULTS
  In the present study, RBP4 concentrations were associated with type 2 diabetes and metabolic syndrome (MetS) components. Of all the individual components of metabolic syndrome that were associated with RBP4 concentrations, the correlations of RBP4 with serum triglycerides and a negative correlation with HDL were the strongest ones observed in our study cohort (p<0.0001).
  
  
  CONCLUSIONS
  RBP4 plays a role in biological mechanisms that are responsible for insulin resistance and development of type 2 diabetes.
authors: Department of Clinical Chemistry and Laboratory Medicine, Sozialmedizinisches Zentrum Ost, Danube Hospital, Vienna, Austria. nazanin.sedille-mostafaie@wienkav.at
authors: Nazanin
authors: N
authors: Mostafaie
authors: Christian
authors: C
authors: Sebesta
authors: Sonja
authors: S
authors: Zehetmayer
authors: Susanne
authors: S
authors: Jungwirth
authors: Klaus R
authors: KR
authors: Huber
authors: Margareta
authors: M
authors: Hinterberger
authors: Thomas
authors: T
authors: Leitha
authors: Jörg
authors: J
authors: Hofman
authors: Milos
authors: M
authors: Hejtman
authors: Karl
authors: K
authors: Schrattbauer
authors: Walter
authors: W
authors: Krugluger
authors: Karl-Heinz
authors: KH
authors: Tragl
authors: Peter
authors: P
authors: Fischer
mesh_terms: D000367:Age Factors; D000368:Aged; D001317:Austria; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D009765:Obesity / Q000097:blood*; D012016:Reference Values; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D013223:Statistics as Topic; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D014280:Triglycerides