title: Validation of insulin sensitivity and secretion indices derived from the liquid meal tolerance test.
abstract: BACKGROUND
  A liquid meal tolerance test (LMTT) has been proposed as a useful alternative to more labor-intensive methods of assessing insulin sensitivity and secretion.
  
  
  OBJECTIVE
  This substudy, conducted at the conclusion of a randomized, double-blind crossover trial, compared insulin sensitivity indices from a LMTT (Matsuda insulin sensitivity index [MISI] and LMTT disposition index [LMTT-DI]) with indices derived from minimal model analysis of results from the insulin-modified intravenous glucose tolerance test (IVGTT) (insulin sensitivity index [S(I)] and disposition index [DI]).
  
  
  RESULTS
  Participants included men (n = 16) and women (n = 8) without diabetes but with increased abdominal adiposity (waist circumference ≥102 cm and ≥89 cm, respectively) and mean age of 48.9 years. The correlation between S(I) and the MISI was 0.776 (P < 0.0001). The respective associations between S(I) and MISI with waist circumference (r = -0.445 and -0.554, both P < 0.05) and body mass index were similar (r = -0.500 and -0.539, P < 0.05). The correlation between DI and LMTT-DI was 0.604 (P = 0.002).
  
  
  CONCLUSIONS
  These results indicate that indices of insulin sensitivity and secretion derived from the LMTT correlate well with those from the insulin-modified IVGTT with minimal model analysis, suggesting that they may be useful for application in clinical and population studies of glucose homeostasis.
authors: Provident Clinical Research, Glen Ellyn, Illinois, USA. KMaki@ProvidentCRC.com
authors: Kevin C
authors: KC
authors: Maki
authors: Kathleen M
authors: KM
authors: Kelley
authors: Andrea L
authors: AL
authors: Lawless
authors: Rachel L
authors: RL
authors: Hubacher
authors: Arianne L
authors: AL
authors: Schild
authors: Mary R
authors: MR
authors: Dicklin
authors: Tia M
authors: TM
authors: Rains
mesh_terms: D050154:Adiposity; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003940:Diagnostic Techniques, Endocrine; D005260:Female; D005526:Food, Formulated; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin