title: Polymorphisms in the neural nicotinic acetylcholine receptor α4 subunit (CHRNA4) are associated with ADHD in a genetic isolate.
abstract: The neural nicotinic acetylcholine receptor α4 subunit (CHRNA4), at 20q13.2-q13.3, is an important candidate gene for conferring susceptibility to attention deficit/hyperactivity disorder (ADHD). Several studies have already looked for association/linkage between ADHD and CHRNA4 in different populations. We used the Pedigree Disequilibrium Test to search for evidence of association between ADHD and six SNP marker loci in families from the isolated Paisa population. We found that the T allele of SNP rs6090384 exhibits a deficit of transmission in unaffected individuals (OR = 5.43, IC 1.54-19.13) (global P value = 0.014). We also found significant association and linkage to extended haplotypes rs2273502-rs6090384 (combination of variants C-T, respectively) (P = 0.02) and rs6090384-rs6090387 (P = 0.04) (combination of variants T-G, respectively). SNP rs6090384, variant T, has also been reported to be associated with inattention in a previous study. This makes ours the ninth study to examine the association of CHRNA4 with ADHD and the seventh one to find evidence for association in a population with a different ethnicity.
authors: Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3717, USA.
authors: Deeann
authors: D
authors: Wallis
authors: Mauricio
authors: M
authors: Arcos-Burgos
authors: Mahim
authors: M
authors: Jain
authors: F Xavier
authors: FX
authors: Castellanos
authors: Juan David
authors: JD
authors: Palacio
authors: David
authors: D
authors: Pineda
authors: Francisco
authors: F
authors: Lopera
authors: Horia
authors: H
authors: Stanescu
authors: Daniel
authors: D
authors: Pineda
authors: Kate
authors: K
authors: Berg
authors: Luis Guillermo
authors: LG
authors: Palacio
authors: Joan E
authors: JE
authors: Bailey-Wilson
authors: Maximilian
authors: M
authors: Muenke
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D011978:Receptors, Nicotinic / Q000235:genetics*
chemical_list: D011978:Receptors, Nicotinic