title: Effects of deoxynivalenol consumption on body weight and adiposity in the diet-induced obese mouse.
abstract: The potential for the obese state to alter sensitivity to toxic chemicals is poorly understood. In this study, dose-response effects of the trichothecene deoxynivalenol (DON), a common food-borne mycotoxin, were determined on body weight of diet-induced obese mice. In study 1, the effects of feeding adult female B6C3F1 mice a high-fat diet (HFD; 60% kcal from fat) containing 0, 2, 5, or 10 ppm DON for 10 wk on body weight and adiposity were compared. Mice consuming 5 or 10 ppm DON exhibited a 15 and 24% decrease in weight gain and a 50 and 83% reduction in periuterine fat, respectively. In study 2, mice were fed HFD for 8 wk to induce obesity and the effects of consuming HFD + 0, 2, 5, or 10 ppm DON for 8 wk were then determined. Mice fed 5 or 10 ppm DON exhibited a 16 and 23% weight reduction and a 0 and 40% periuterine fat reduction, respectively. In a follow-up experiment, food consumption was measured prior to and after the transition from HFD to HFD + 10 ppm DON. Exposure to DON was found to lower HFD consumption within 1 d, with significant weight loss in DON-fed mice evident after 6 d. In both studies 1 and 2, consumption of 5 or 10 ppm DON diminished circulating levels of insulin-like growth factor acid-labile subunit. Taken together, DON consumption lowered weight gain and produced weight loss in diet-induced obese mice at higher thresholds than that observed previously in normal B6C3F1 mice.
authors: Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA.
authors: C J
authors: CJ
authors: Amuzie
authors: B M
authors: BM
authors: Flannery
authors: A M
authors: AM
authors: Ulrich
authors: J J
authors: JJ
authors: Pestka
mesh_terms: D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008820:Mice, Obese; D011042:Poisons / Q000008:administration & dosage / Q000633:toxicity*; D014255:Trichothecenes / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D011042:Poisons; D014255:Trichothecenes; C007262:deoxynivalenol