title: Translating cancer research by synthetic biology.
abstract: Synthetic biology concerns applying engineering principles to biological systems. Engineering properties such as fine tuning, novel specificity, and modularity could be components of a synthetic toolkit that can be exploited to explore various issues in cancer research such as elucidation of mechanisms and pathways, creating new diagnostic tools and novel therapeutic approaches. A repertoire of synthetic biology toolkits involving DNA, RNA and protein bio-parts, have been applied to address the issues of drug target identification, drug discovery and therapeutic treatment in cancer research, thereby projecting a new dimension in oncology research.
authors: Integrated Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thycaud. PO, Thiruvananthapuram, 695 014, Kerala State, India.
authors: Sumitra
authors: S
authors: Shankar
authors: M Radhakrishna
authors: MR
authors: Pillai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D057005:Bioengineering / Q000379:methods*; D016503:Drug Delivery Systems; D055808:Drug Discovery / Q000379:methods; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D015202:Protein Engineering / Q000379:methods; D058615:Synthetic Biology / Q000379:methods*; D057170:Translational Research, Biomedical
chemical_list: D000970:Antineoplastic Agents