title: [Ocular pseudoexfoliation syndrome].
abstract: BACKGROUND
  This study was aimed at providing an update on most recent developments regarding ocular and systemic manifestations and complications, clinical diagnosis and management, and molecular patophysiology of pseudoexfoliation syndrome.
  
  
  METHODS
  Review of recent literature and own clinical and laboratory studies.
  
  
  RESULTS
  Pseudoexfoliation syndrome is an age-related disease in which abnormal fibrillar extracellular material is produced and accumulated in many ocular tissues. Recent progress and advances have led to improvements in clinical management by understanding the effects of the pseudoexfoliation process on the ocular tissues, by refining diagnostic criteria and applying new treatment regimes, and by developing preventive strategies to reduce surgical complications. Increasing evidence of systemic associations of cardiovascular, cerebrovascular, abdominal aorta aneurysm can provide better understanding and management of this condition, and new therapeutic goal. The current pathogenesis concept describes psuedoexfoliation syndrome as an elastic microfibrillopathy involving transforming growth factor-beta, matrix metalloproteinase oxidative stress.
  
  
  CONCLUSIONS
  Despite extensive research, the exact chemical composition of exfoliation material remains unknown. The presence of pseudoexfoliation should alert the physician to the increased risks of intraocular surgery, most commonly zonular dehiscence, capsular rupture, and vitreous loss during cataract extraction. Its associated clinical signs are important in the detection and management of glaucoma.
authors: Klinicki centar Nis, Nis. jdjordjevic.jocic@gmail.com
authors: Jasmina
authors: J
authors: Dordević-Jocić
authors: Gordana
authors: G
authors: Zlatanović
authors: Dragan
authors: D
authors: Veselinović
authors: Gordana
authors: G
authors: Stanković-Babić
authors: Milena
authors: M
authors: Vujanović
authors: Maja
authors: M
authors: Zivković
mesh_terms: D017889:Exfoliation Syndrome / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D006801:Humans