title: Spontaneous liver rupture after treatment with drug-eluting beads.
abstract: Spontaneous rupture of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) is a rare and life-threatening complication. Pathophysiologic mechanisms are not yet fully known; it is suggested that rupture is preceded by reactive tissue edema and intratumerous bleeding, leading to a rapid expansion of tumour mass with risk of extrahepatic bleeding in the case of subcapsular localisation. This case report discusses a sudden, unexpected lethal complication in a 74 year-old male patient treated with TACE using DC Bead loaded with doxorubicin (DEBDOX) in a progressive multifocal HCC.
authors: Institute of Radiology, University of Würzburg, Oberdürrbacherstrasse 6, 97080 Würzburg, Germany. ritter@roentgen.uni-wuerzburg.de
authors: C O
authors: CO
authors: Ritter
authors: M
authors: M
authors: Wartenberg
authors: A
authors: A
authors: Mottok
authors: U
authors: U
authors: Steger
authors: J P
authors: JP
authors: Goltz
authors: D
authors: D
authors: Hahn
authors: R
authors: R
authors: Kickuth
mesh_terms: D000368:Aged; D000792:Angiography; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D003287:Contrast Media / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage*; D017809:Fatal Outcome; D006801:Humans; D007479:Iopamidol / Q000008:administration & dosage / Q000031:analogs & derivatives; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008863:Microspheres; D012422:Rupture, Spontaneous; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; C057937:iomeprol; D004317:Doxorubicin; D007479:Iopamidol