title: Health-related quality of life and fatigue in patients with adrenal incidentaloma.
abstract: The objective of the present study was to examine several dimensions of quality of life (QoL) and fatigue in patients with adrenal incidentaloma. This was a case-control study designed to analyze patient outcomes using three validated generic QoL questionnaires, EQ-5D, SF-36, and MFI-20, the results of which were compared to those obtained for age- and sex-matched controls. The study population comprised 139 consecutive patients with nonfunctioning adrenal masses (104 females, 35 males; age 59.1 ± 10.8) and 139 age- and sex-matched controls. Reduced QoL was found in patients with adrenal incidentaloma as compared to controls. Dimensions of QoL that were notably affected included mobility (P = 0.03), performance of usual activities (P = 0.002), and anxiety/depression (P = 0.04) as evaluated using the EQ-5D; physical functioning (P < 0.001), physical role (P < 0.001), general health (P < 0.001), vitality (P = 0.001), social functioning (P = 0.001), and emotional role (P < 0.001) as evaluated using the SF-36; and physical fatigue (P = 0.04) as assessed using the MFI-20 questionnaire. In addition, perceived health on a visual analogue scale was also significantly lower in patients than in controls (64.8 ± 19.2 vs. 77.1 ± 15.1; P < 0.001). Patients with adrenal incidentaloma reported reduced QoL and a higher level of physical fatigue compared to age- and sex-matched controls. This subject will benefit from further studies comparing QoL outcomes of laparoscopic adrenalectomy versus no treatment in patients with adrenal incidentaloma.
authors: School of Medicine, University of Zagreb, Zagreb, Croatia. dkastelan@inet.hr
authors: Darko
authors: D
authors: Kastelan
authors: Fedja
authors: F
authors: Dzubur
authors: Tina
authors: T
authors: Dusek
authors: Tamara
authors: T
authors: Poljicanin
authors: Zeljka
authors: Z
authors: Crncevic-Orlic
authors: Ivana
authors: I
authors: Kraljevic
authors: Mirsala
authors: M
authors: Solak
authors: Tanja
authors: T
authors: Bencevic
authors: Izet
authors: I
authors: Aganovic
authors: Nikola
authors: N
authors: Knezevic
authors: Zeljko
authors: Z
authors: Kastelan
authors: Mirko
authors: M
authors: Korsic
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D000368:Aged; D016022:Case-Control Studies; D003863:Depression / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D005221:Fatigue / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires