title: Effect of teriparatide on induced tooth displacement in ovariectomized rats: a histomorphometric analysis.
abstract: BACKGROUND
  The aim of this study was to evaluate morphologically the effect of teriparatide on induced orthodontic movement of the maxillary first molars in ovariectomized rats.
  
  
  METHODS
  Ovariectomized Wistar rats (n = 16), ovariectomized rats treated with teriparatide (n = 16), and nonovariectomized rats (n = 16) had orthodontic tooth movement for 5 and 7 days. The group treated with teriparatide received a subcutaneous injection (Forteo, Eli Lilly, Indianapolis, Ind; 30 μg/kg/day) for 90 days after the ovariectomy. Histologic sections obtained from the maxilla were prepared for the morphometric analysis of dental movement, the thickness of the periodontal ligament, and the number of osteoclasts in the pressure and tension areas of the apex of the root and alveolar crest in the distal root of the maxillary first molars.
  
  
  RESULTS
  The ovariectomized rats treated with teriparatide had similar responses at 5 and 7 days after the induced dental movements compared with the untreated ovariectomized group. Both ovariectomized groups had greater molar movement on day 7 day compared with the controls (P <0.05). There were no statistically significant differences between groups in the spacing of the periodontal ligament or the number of osteoclasts in the areas studied.
  
  
  CONCLUSIONS
  These data suggest that the treatment of osteoporosis with teriparatide is a good alternative for patients undergoing orthodontic treatment.
authors: Program in Health Science, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. marciosalazar@hotmail.com
authors: Marcio
authors: M
authors: Salazar
authors: Luzmarina
authors: L
authors: Hernandes
authors: Adilson Luiz
authors: AL
authors: Ramos
authors: Kelly Regina
authors: KR
authors: Micheletti
authors: Claudio Cordeiro
authors: CC
authors: Albino
authors: Roberto Kenji
authors: RK
authors: Nakamura Cuman
mesh_terms: D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002452:Cell Count; D003720:Densitometry; D005260:Female; D007279:Injections, Subcutaneous; D008437:Maxilla / Q000187:drug effects / Q000473:pathology; D008963:Molar / Q000187:drug effects* / Q000473:pathology; D009969:Orthodontic Wires; D010010:Osteoclasts / Q000187:drug effects / Q000473:pathology; D010052:Ovariectomy; D010513:Periodontal Ligament / Q000187:drug effects / Q000473:pathology; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D019379:Teriparatide / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D019227:Tooth Apex / Q000187:drug effects / Q000473:pathology; D014087:Tooth Movement Techniques / Q000295:instrumentation; D014092:Tooth Root / Q000187:drug effects / Q000473:pathology
chemical_list: D050071:Bone Density Conservation Agents; D019379:Teriparatide