title: Change in PASAT performance correlates with change in P3 ERP amplitude over a 12-month period in multiple sclerosis patients.
abstract: OBJECTIVE
  To examine the correlation between the change in PASAT and the change in P3 event-related potentials (ERPs) over a 12-month period in multiple sclerosis (MS) patients, and to compare the 12-month change in the P3 ERP between MS patients and controls.
  
  
  METHODS
  Forty-four subjects (27 MS patients, 17 controls) completed visual and auditory two-stimulus oddball and three-stimulus oddball tasks at Month 0 and Month 12. Data were recorded from a 128-scalp channel electroencephalography array. Data from scalp channels were converted into continuous interpolated images (incorporating the entire scalp and time). Amplitude, topographical differences and correlations were then tested using statistical parametric mapping.
  
  
  RESULTS
  The change in visual and auditory P3a correlated significantly with the change in PASAT score (r=0.56, p<0.001 and r=0.48, p=0.003, respectively). Visual P3b and P3a showed greater decrease in 12 months in MS patients relative to controls. Visual P3b, auditory P3b and auditory P3a amplitudes had significantly decreased in MS patients after 12-month period.
  
  
  CONCLUSIONS
  Change in visual and auditory P3a ERP amplitudes correlate with change in PASAT scores in MS patients. Visual modality is more sensitive to changes in P3 ERP amplitudes over 12-month period.
  
  
  CONCLUSIONS
  P3 ERPs may have utility in monitoring the change in cognitive functioning in MS.
authors: Trinity Centre for Bioengineering, Trinity College Dublin, College Green, Dublin 2, Ireland.
authors: H
authors: H
authors: Kiiski
authors: R B
authors: RB
authors: Reilly
authors: R
authors: R
authors: Lonergan
authors: S
authors: S
authors: Kelly
authors: M
authors: M
authors: O'Brien
authors: K
authors: K
authors: Kinsella
authors: J
authors: J
authors: Bramham
authors: T
authors: T
authors: Burke
authors: S
authors: S
authors: O'Donnchadha
authors: H
authors: H
authors: Nolan
authors: M
authors: M
authors: Hutchinson
authors: N
authors: N
authors: Tubridy
authors: R
authors: R
authors: Whelan
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D018450:Disease Progression; D004569:Electroencephalography / Q000379:methods; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D009483:Neuropsychological Tests / Q000592:standards