title: Breakthrough lung Scedosporium prolificans infection with multiple cavity lesions in a patient receiving voriconazole for probable invasive aspergillosis associated with monoclonal gammopathy of undetermined significance (MGUS).
abstract: Breakthrough non- Aspergillus mold infections among patients receiving the anti-mold azole antifungal agents like voriconazole or posaconazole have been increasingly reported. We report a case of lung Scedosporium prolificans infection with multiple cavities in a 58-year-old man with monoclonal gammopathy of undetermined significance (MGUS) during voriconazole treatment for probable invasive aspergillosis. Cultures of repeated sputum specimens yielded the same fungus until his death 83 days after diagnosis. S. prolificans should be considered in patients with breakthrough infections receiving voriconazole.
authors: Department of Respiratory Medicine, Juntendo University.
authors: Rina
authors: R
authors: Ohashi
authors: Motoyasu
authors: M
authors: Kato
authors: Yoko
authors: Y
authors: Katsura
authors: Hidenori
authors: H
authors: Takekawa
authors: Yoshito
authors: Y
authors: Hoshika
authors: Tomonori
authors: T
authors: Sugawara
authors: Kaku
authors: K
authors: Yoshimi
authors: Shinsaku
authors: S
authors: Togo
authors: Tetsutaro
authors: T
authors: Nagaoka
authors: Kuniaki
authors: K
authors: Seyama
authors: Kazuhisa
authors: K
authors: Takahashi
authors: Koji
authors: K
authors: Tsuchiya
authors: Shigeki
authors: S
authors: Misawa
authors: Ken
authors: K
authors: Kikuchi
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage*; D017809:Fatal Outcome; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008271:Mycetoma / Q000188:drug therapy / Q000209:etiology*; D010265:Paraproteinemias / Q000150:complications*; D055732:Pulmonary Aspergillosis / Q000188:drug therapy* / Q000209:etiology*; D011743:Pyrimidines / Q000008:administration & dosage*; D021681:Scedosporium; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole