title: Emergence of four cases of KPC-2 and KPC-3-carrying Klebsiella pneumoniae introduced to Switzerland, 2009-10.
abstract: We report four epidemiologically unrelated cases of KPC-carrying Klebsiella pneumoniae identified in Switzerland between May 2009 and November 2010. Three cases were transferred from Italy (two KPC-3, one KPC-2) and one from Greece (KPC-2). Resistance to colistin and doxycycline emerged in one KPC-3-carrying K. pneumoniae strain during therapy. These results demonstrate ongoing dissemination of KPC throughout Europe. Rapid and reliable identification of KPC and implementation of control measures is essential to limit spread.
authors: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
authors: B
authors: B
authors: Babouee
authors: A F
authors: AF
authors: Widmer
authors: O
authors: O
authors: Dubuis
authors: D
authors: D
authors: Ciardo
authors: S
authors: S
authors: Droz
authors: B Y
authors: BY
authors: Betsch
authors: C
authors: C
authors: Garzoni
authors: U
authors: U
authors: Führer
authors: M
authors: M
authors: Battegay
authors: R
authors: R
authors: Frei
authors: D
authors: D
authors: Goldenberger
mesh_terms: D000368:Aged; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005260:Female; D006115:Greece; D006801:Humans; D007558:Italy; D007710:Klebsiella Infections / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D013045:Species Specificity; D013557:Switzerland / Q000453:epidemiology; D016896:Treatment Outcome; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C547585:beta-lactamase KPC-2, Klebsiella pneumoniae; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae