title: All-cause mortality and serum insulin-like growth factor I in primary care patients.
abstract: OBJECTIVE
  Previous population-based studies provided conflicting results regarding the association of total serum insulin-like growth factor I (IGF-I) and mortality. The aim of the present study was to assess the relation of IGF-I levels with all-cause mortality in a prospective study.
  
  
  METHODS
  DETECT (Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment) is a large, multistage, and nationally representative study of primary care patients in Germany. The study population included 2463 men and 3603 women. Death rates were recorded by the respective primary care physician. Serum total IGF-I levels were determined by chemiluminescence immunoassays and categorized into three groups (low, moderate, and high) according to the sex- and age-specific 10th and 90th percentiles.
  
  
  RESULTS
  Adjusted analyses revealed that men with low [hazard ratio (HR) 1.70 (95% confidence interval [CI] 1.05-2.73), p=0.03] and high [HR 1.76 (95% CI 1.09-2.85), p=0.02] IGF-I levels had higher risk of all-cause mortality compared to men with moderate IGF-I levels. The specificity of low IGF-I and high IGF-I levels increased with lower and higher cut-offs, respectively. No such association became apparent in women.
  
  
  CONCLUSIONS
  The present study revealed a U-shaped relation between IGF-I and all-cause mortality in male primary care patients.
authors: Institute for Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University of Greifswald, Germany. nele.friedrich@uni-greifswald.de
authors: N
authors: N
authors: Friedrich
authors: H
authors: H
authors: Schneider
authors: M
authors: M
authors: Dörr
authors: M
authors: M
authors: Nauck
authors: H
authors: H
authors: Völzke
authors: J
authors: J
authors: Klotsche
authors: C
authors: C
authors: Sievers
authors: D
authors: D
authors: Pittrow
authors: S
authors: S
authors: Böhler
authors: H
authors: H
authors: Lehnert
authors: L
authors: L
authors: Pieper
authors: H-U
authors: HU
authors: Wittchen
authors: H
authors: H
authors: Wallaschofski
authors: G K
authors: GK
authors: Stalla
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000401:mortality; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011320:Primary Health Care; D011446:Prospective Studies; D012306:Risk; D016019:Survival Analysis
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I