title: Release kinetics of β-cyfluthrin from its encapsulated formulations in water.
abstract: Controlled release formulations of β-cyfluthrin, a non-systemic, broad spectrum contact insecticide, have been prepared using laboratory synthesized poly(ethylene glycol) (PEG) based amphiphilic copolymers. Copolymers of polyethylene glycols of different molecular weights and various dimethyl esters, viz. dimethyl isophthalate, which self assemble into nano micellar aggregates in aqueous media, have been synthesized. The kinetics of β-cyfluthrin from developed controlled release (CR) formulations were studied in comparison with that of the commercially available 025 SC. Release from the commercial formulation was faster than with the developed CR formulations. The rate of release of encapsulated β-cyfluthrin from nano micellar aggregates is reduced by increasing the molecular weight of PEG. The diffusion exponent (n value) of β-cyfluthrin in water ranged from 0.427 to 0.622 in the tested formulations. The release was diffusion controlled with a half-release time (t(½)) of 3.92 to 7.9 days in water from different formulations, and the period of optimum availability (POA) of β-cyfluthrin ranged from 1.4 to 20.5 days. The results suggest that the application rate of β-cyfluthrin can be optimized to achieve insect control at the desired level and period.
authors: Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi, India.
authors: Kumelachew M
authors: KM
authors: Loha
authors: Najam A
authors: NA
authors: Shakil
authors: Jitendra
authors: J
authors: Kumar
authors: Manish K
authors: MK
authors: Singh
authors: Totan
authors: T
authors: Adak
authors: Suresh
authors: S
authors: Jain
mesh_terms: D002214:Capsules / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000032:analysis*; D004058:Diffusion; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D008970:Molecular Weight; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D011722:Pyrethrins / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D014867:Water; D011092:Polyethylene Glycols; C052570:cyfluthrin