title: Inhibition of UV-induced ROS and collagen damage by Phyllanthus emblica extract in normal human dermal fibroblasts.
abstract: As a part of ongoing research for novel natural cosmeceutical actives from plant extracts, this study demonstrates that Phyllanthus emblica fruit extract has shown its efficacy in protection against ultraviolet-B (UVB) irradiation-induced reactive oxygen species (ROS) and collagen damage in normal human dermal fibroblasts. At a concentration of 0.5 mg/ml, emblica extract showed a significant response of 9.5 ± 0.28-fold protection from UVB induced-collagen damage as compared to untreated cells. A known active, ascorbic acid, at a concentration of 0.5 mg/ml, showed 3.7 ± 0.07-fold protection from UVB-induced collagen damage. While the untreated cells showed 84 ± 1.4% induction in ROS on UVB irradiation as compared to the non-irradiated cells, emblica extract treatment inhibited the induction of ROS to 15 ± 4% at a concentration of 0.5 mg/ml. Ascorbic acid inhibited the induction in ROS to 64 ± 2% at a concentration of 0.5 mg/ml. Emblica extract is a significantly better natural active, with promising cosmeceutical benefits against photoaging.
authors: Sami Labs Limited, Peenya Industrial Area, Bangalore 560058, India.
authors: Muhammed
authors: M
authors: Majeed
authors: Beena
authors: B
authors: Bhat
authors: Susmitha
authors: S
authors: Anand
authors: A
authors: A
authors: Sivakumar
authors: Pritee
authors: P
authors: Paliwal
authors: K G
authors: KG
authors: Geetha
mesh_terms: D003094:Collagen / Q000378:metabolism*; D020405:Dermis / Q000166:cytology; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D029842:Phyllanthus emblica / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: D010936:Plant Extracts; D017382:Reactive Oxygen Species; D003094:Collagen