title: A new rapid multicomponent domino reaction for the formation of functionalized benzo[h]pyrazolo[3,4-b]quinolines.
abstract: A new multicomponent domino reaction for rapid and regioselective synthesis of highly functionalized benzo[h]pyrazolo[3,4-b]quinolines has been established. The reaction can be conducted by using readily available and inexpensive substrates under microwave irradiation within short periods of 10-26 min. Good to excellent chemical yields (61-91%) and complete regioselectivity have been achieved for 22 examples. Tedious work-up procedure can be avoided due to the direct precipitation of products from the reaction solution. The resulting benzoquinolines have been readily converted into quinoxaline-fused benzo[h]isoxazolo[5,4-b]quinoline analogues by treating with benzene-1,2-diamine under microwave irradiation. The structural assignment has been ambiguously confirmed by X-ray analysis. A new mechanism has been proposed for this new multicomponent domino process.
authors: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Jiangsu, PR China.
authors: Bo
authors: B
authors: Jiang
authors: Ge
authors: G
authors: Zhang
authors: Ning
authors: N
authors: Ma
authors: Feng
authors: F
authors: Shi
authors: Shu-Jiang
authors: SJ
authors: Tu
authors: Parminder
authors: P
authors: Kaur
authors: Guigen
authors: G
authors: Li
mesh_terms: D007700:Kinetics; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D011804:Quinolines