title: Th17/Treg imbalance in adult patients with minimal change nephrotic syndrome.
abstract: To determine whether Th17/Treg balance was abnormal in adult patients with minimal change nephrotic syndrome (MCNS), we studied 25 patients with new-onset MCNS and 20 normal persons. The results showed that MCNS patients exhibited a significant increase in Th17 number, Th17-related cytokines (IL-17 and IL-23), and transcription factor (RORγt) levels, as well as an obvious decrease in Treg number, Treg-related cytokines (TGF-β1 and IL-10), and transcription factor (Foxp3) levels. The Th17/Treg ratios increased along with increased proteinuria and decreased albumin levels in patients with MCNS. IL-17 protein expression was also detected in the renal biopsy tissue of MCNS patients, particularly in patients with acute renal failure. Further, Th17/Treg balance returned to normal after effective corticosteroids therapy in 16 MCNS patients. These results indicated that Th17/Treg imbalance existed in MCNS patients, suggesting a potential role of Th17/Treg imbalance in the pathogenesis of MCNS.
authors: Division of Nephrology, Department of Internal Medicine, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors: Li-Li
authors: LL
authors: Liu
authors: Yan
authors: Y
authors: Qin
authors: Jian-Fang
authors: JF
authors: Cai
authors: Hai-Yun
authors: HY
authors: Wang
authors: Jian-Ling
authors: JL
authors: Tao
authors: Hang
authors: H
authors: Li
authors: Li-Meng
authors: LM
authors: Chen
authors: Ming-Xi
authors: MX
authors: Li
authors: Xue-Mei
authors: XM
authors: Li
authors: Xue-Wang
authors: XW
authors: Li
mesh_terms: D000328:Adult; D001706:Biopsy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors / Q000097:blood / Q000235:genetics / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000097:blood / Q000276:immunology; D020381:Interleukin-17 / Q000097:blood / Q000276:immunology; D053759:Interleukin-23 / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000097:blood / Q000276:immunology / Q000473:pathology; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000097:blood / Q000235:genetics / Q000276:immunology; D012313:RNA / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology; D058504:Th17 Cells / Q000276:immunology* / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000097:blood / Q000276:immunology
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D020381:Interleukin-17; D053759:Interleukin-23; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D053773:Transforming Growth Factor beta1; D016753:Interleukin-10; D012313:RNA