title: Design of polyphosphazene hydrogels with improved structural properties by use of star-shaped multithiol crosslinkers.
abstract: The feasibility of using a star-shaped crosslinker to produce a hydrogel with controlled mechanical properties and degradation rates was investigated. The aqueous blends of functional polymers and crosslinkers formed a solution at low temperature and a hydrogel with desired mechanical properties at body temperature. The introduction of star-shaped crosslinkers affected the microscopic and macroscopic properties of the hydrogel. The fabricated hydrogels could be suitable for many potential biomedical applications because of their injectability, tunable mechanical properties, controlled degradation rate and gel formation under physiological conditions.
authors: Division of Life and Health Science, Korean Institute of Science and Technology, Seoul, Republic of Korea.
authors: Thrimoorthy
authors: T
authors: Potta
authors: Changju
authors: C
authors: Chun
authors: Soo-Chang
authors: SC
authors: Song
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004548:Elasticity; D020100:Hydrogels / Q000737:chemistry* / Q000633:toxicity; D020007:Implants, Experimental; D008422:Materials Testing; D051379:Mice; D008819:Mice, Nude; D008970:Molecular Weight; D041681:NIH 3T3 Cells; D009943:Organophosphorus Compounds / Q000737:chemistry* / Q000633:toxicity; D011108:Polymers / Q000737:chemistry* / Q000633:toxicity; D013439:Sulfhydryl Reagents / Q000737:chemistry*; D023822:Tissue Engineering; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020100:Hydrogels; D009943:Organophosphorus Compounds; D011108:Polymers; D013439:Sulfhydryl Reagents; C108974:poly(phosphazene)