title: [Pandemic influenza virus A (H1N1) in Amur region in autumn 2009].
abstract: OBJECTIVE
  Isolation and study of molecular genetic characteristics of pandemic influenza virus A (H1N1) circulated in Amur region in autumn 2009 as well as testing of serum samples taken from citizens of this region during November- December 2009 in order to measure levels of antibodies to socially significant serotypes of influenza A virus.
  
  
  METHODS
  Strain of pandemic influenza virus A/Blagoveschensk/01/2009 (H1N1) was isolated on MDCK cell culture and nucleotide sequences of all eight segments of viral genome were determined. Five hundred seventy-six serum samples taken in Amur region in autumn 2009 were tested by hemagglutination inhibition assay.
  
  
  RESULTS
  Nucleotide sequence of A/Blagovechensk/01/2009 (H1N1) strain was 99.7% identical to reference influenza virus strain A/California/04/2009. Diagnostically significant titers of antibodies to pandemic influenza virus were observed in 46.3% of persons younger 30 years old and in 20.1% older persons. Antibodies to seasonal influenza virus H1N1 and H3N2 were detected in 39.5 and 29.8% of persons respectively.
  
  
  CONCLUSIONS
  Final seroepidemiological picture of distribution of pandemic virus in Amur region matches with the one for seasonal influenza virus A (H1N1): > 60% of seropositive persons were registered in age group < 18 years old, and this proportion increases with increasing age.
authors: A A
authors: AA
authors: romanovskaia
authors: T N
authors: TN
authors: I'icheva
authors: A G
authors: AG
authors: Durymanov
authors: M B
authors: MB
authors: Ignashkina
authors: K A
authors: KA
authors: Sharshov
authors: I M
authors: IM
authors: Susloparov
authors: E M
authors: EM
authors: Malkova
authors: E A
authors: EA
authors: Stavskiĭ
authors: A M
authors: AM
authors: Shestopalov
authors: V T
authors: VT
authors: Smirnov
authors: N N
authors: NN
authors: Zhukova
authors: I I
authors: II
authors: Pavlova
authors: T Iu
authors: TIu
authors: Nekhriuk
authors: T P
authors: TP
authors: Panamareva
authors: I G
authors: IG
authors: Drozdov
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D002460:Cell Line; D004285:Dogs; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D007251:Influenza, Human / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D058873:Pandemics; D012621:Seasons; D016036:Seroepidemiologic Studies; D012800:Siberia / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral