title: Exon 11 deletion in the myocyte enhancer factor (MEF)2A and early onset coronary artery disease gene in a Sicilian family.
abstract: OBJECTIVE
  We investigated the prevalence of the myocyte enhancer factor (MEF)2A exon 11 deletion, a putative coronary artery disease (CAD) susceptibility gene, in patients referred for coronary angiography.
  
  
  RESULTS
  In total, 1079 consecutive patients referred for coronary angiography in the GENICA Study were genotyped and 301 low-risk subjects were used as controls. One patient with early onset three vessels CAD, carrying the MEF2A deletion was found in the GENICA Study cohort and none in the control group.
  
  
  CONCLUSIONS
  In a cohort of patients undergoing coronary angiography for suspected CAD the MEF2A exon 11 deletion occurred in 0.09%.
authors: Department of Cardiovascular Diseases, Cittadella General Hospital, Cittadella, Italy.
authors: Giuseppe
authors: G
authors: Maiolino
authors: Stefania
authors: S
authors: Colonna
authors: Mario
authors: M
authors: Zanchetta
authors: Luigi
authors: L
authors: Pedon
authors: Teresa Maria
authors: TM
authors: Seccia
authors: Maurizio
authors: M
authors: Cesari
authors: Saula
authors: S
authors: Vigili de Kreutzenberg
authors: Angelo
authors: A
authors: Avogaro
authors: Gian Paolo
authors: GP
authors: Rossi
mesh_terms: D017668:Age of Onset; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics*; D004252:DNA Mutational Analysis; D005091:Exons; D017353:Gene Deletion; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006801:Humans; D026161:MADS Domain Proteins / Q000235:genetics*; D064326:MEF2 Transcription Factors; D008297:Male; D008875:Middle Aged; D018006:Myogenic Regulatory Factors / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012802:Sicily / Q000453:epidemiology
chemical_list: D026161:MADS Domain Proteins; D064326:MEF2 Transcription Factors; C578035:MEF2A protein, human; D018006:Myogenic Regulatory Factors