title: Dexamethasone pulse therapy in patients of systemic sclerosis: is it a viable proposition? A study from kashmir.
abstract: BACKGROUND
  Systemic sclerosis is a multisystemic autoimmune disorder. Intravenous dexamethasone pulse therapy has been used since 1998.
  
  
  OBJECTIVE
  The aim wasto report the beneficial effects of dexamethasone pulse in patients of systemic sclerosis vis-à-vis the side effects.
  
  
  METHODS
  Forty-seven patients of systemic sclerosis were included. After looking at the history and physical examination, the patients were submitted to various relevant investigations. Clinical scoring of the patient was done at baseline and 6-month interval according to Furst's organ indices score.
  
  
  RESULTS
  A total of47 patients of systemic sclerosis were included (45 females, 2 males). In majority, acrosclerosis was seen. Severe sclerosis and contractures were seen in two patients. Moderate proteinuria, restrictive lung disease, dysphagia, and valvular heart involvement were seen.A total of13 patients on dexamethasone pulse therapy developed tuberculosis. Improvement in skin scoring and decreased severity of Raynaud's phenomenon was seen. No improvement in dysphagia, severe vascular symptoms, or restrictive lung disease was seen.
  
  
  CONCLUSIONS
  Thus, beneficial effects of dexamethasone pulse therapy seem to be merely cosmetic.
authors: Department of Dermatology, STD and Leprosy, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors: Farah
authors: F
authors: Sameem
authors: Iffat
authors: I
authors: Hassan
authors: Qazi Masood
authors: QM
authors: Ahmad
authors: Dilshad
authors: D
authors: Khan
authors: Imran
authors: I
authors: Majeed
authors: M A
authors: MA
authors: Kamili
authors: Parvaiz A
authors: PA
authors: Shah