title: [Prodrug technology in the development of medicinal agents].
abstract: Medicinal agents acetosalicylic acid, lansoprazole, simvastatin, clopidogrel and oseltamivir are known prodrugs. Prodrugs are pharmacologically inactive medicine molecules, from which the active drug is released in the body through a chemical or enzymatic reaction. This mechanism can be used to solve pharmaceutical and pharmacokinetic problems restricting the use of medicinal agents, without altering the pharmacological effects of the agent that ends up in the site of action. Of the medicinal agents currently on the market, as many as one out of ten is a prodrug.
authors: Itä-Suomen yliopisto, terveystieteiden tiedekunta, farmasian laitos, PL 1627, 70211 Kuopio.
authors: Lauri
authors: L
authors: Peura
authors: Kalle
authors: K
authors: Malmioja
authors: Jarkko
authors: J
authors: Rautio
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D000077144:Clopidogrel; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D064747:Lansoprazole; D053139:Oseltamivir / Q000494:pharmacology; D011355:Prodrugs / Q000494:pharmacology*; D019821:Simvastatin / Q000494:pharmacology; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D011355:Prodrugs; D064747:Lansoprazole; D053139:Oseltamivir; D000077144:Clopidogrel; D019821:Simvastatin; D013988:Ticlopidine; D001241:Aspirin