title: Highly efficient drug delivery nanosystem via L-phenylalanine triggering based on supramolecular polymer micelles.
abstract: An intelligent drug delivery nanosystem has been developed based on biodegradable supramolecular polymer micelles (SMPMs). The drug release can be triggered from SMPMs responsively by a bioactive agent, L-phenylalanine in a controlled fashion. The SMPMs are constructed from ethylcellulose-graft-poly(ε-caprolactone) (EC-g-PCL) and α-cyclodextrin (α-CD) derivate via host-guest and hydrophobic interactions. It has been found that these SMPMs have disassembled rapidly in response to an additional L-phenylalanine, due to great affinity discrepancy to α-CD between L-phenylalanine and PCL. Experiments have been carried out on trigger-controlled in vitro drug release of the SMPMs loaded with a model porphyrin based photosensitizer THPP. The result shows that the SMPMs released over 85% THPP in 6 h, which is two orders magnitudes faster than that of control. Also investigated is the photodynamic therapy (PDT) of THPP-loaded SMPMs with and without L-phenylalanine on MCF-7 carcinoma cell line. An effective trigger-concentration dependent lethal effect has been found showing promise in clinical photodynamic therapy.
authors: The Institute for Advanced Materials and Nano Biomedicine (iNANO), Tongji University, Shanghai 200092, PR China.
authors: Haiqing
authors: H
authors: Dong
authors: Yongyong
authors: Y
authors: Li
authors: Huiyun
authors: H
authors: Wen
authors: Meng
authors: M
authors: Xu
authors: Lijian
authors: L
authors: Liu
authors: Zhuoquan
authors: Z
authors: Li
authors: Fangfang
authors: F
authors: Guo
authors: Donglu
authors: D
authors: Shi
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D061986:MCF-7 Cells; D008823:Micelles; D036103:Nanotechnology; D010649:Phenylalanine / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D047391:alpha-Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D008823:Micelles; D011108:Polymers; D047391:alpha-Cyclodextrins; D010649:Phenylalanine; C032613:alpha-cyclodextrin