title: Synovial sarcoma of the kidney: a report of 4 cases with pathologic appraisal and differential diagnostic review.
abstract: BACKGROUND
  Synovial sarcoma of the kidney is rare. It is clinicoradiologically indistinguishable from the more frequently encountered renal cell carcinoma. Histologically it needs to be differentiated from other spindle cell lesions occurring within the kidney, including a spectrum of benign to malignant tumors. Among malignant spindle cell tumors of the kidney, mimics of synovial sarcoma are sarcomatoid renal cell carcinoma, sarcomatoid urothelial carcinoma and other primary sarcomas, such as leiomyosarcoma and malignant fibrous histiocytoma.
  
  
  METHODS
  Four cases of synovial sarcoma originated in the kidney, with this report focusing on clinicopathologic and differential diagnostic features.
  
  
  CONCLUSIONS
  The correct diagnosis of synovial sarcoma requires support by an immunohistochemical panel as well as adjunctive investigations like polymerase chain reaction and fluorescence in situ hybridization to determine the presence of the SYT-SSX fusion gene and translocation (X,18), respectively.
authors: Department of Urology, Singapore General Hospital, Singapore.
authors: Yia Swam
authors: YS
authors: Tan
authors: Lay Guat
authors: LG
authors: Ng
authors: Sidney Kam-Hung
authors: SK
authors: Yip
authors: Miah-Hiang
authors: MH
authors: Tay
authors: Alvin Soon-Tiong
authors: AS
authors: Lim
authors: Sim Leng
authors: SL
authors: Tien
authors: Liang
authors: L
authors: Cheng
authors: Puay Hoon
authors: PH
authors: Tan
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000378:metabolism; D013584:Sarcoma, Synovial / Q000378:metabolism / Q000473:pathology*
chemical_list: D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein