title: Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex.
abstract: A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective response of the fluorescent probe arises from end-stack binding to G-quadruplex.
authors: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
authors: Yu-Jing
authors: YJ
authors: Lu
authors: Siu-Cheong
authors: SC
authors: Yan
authors: Fung-Yi
authors: FY
authors: Chan
authors: Lan
authors: L
authors: Zou
authors: Wai-Hong
authors: WH
authors: Chung
authors: Wing-Leung
authors: WL
authors: Wong
authors: Bin
authors: B
authors: Qiu
authors: Ning
authors: N
authors: Sun
authors: Pak-Ho
authors: PH
authors: Chan
authors: Zhi-Shu
authors: ZS
authors: Huang
authors: Lian-Quan
authors: LQ
authors: Gu
authors: Kwok-Yin
authors: KY
authors: Wong
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry; D001665:Binding Sites; D045744:Cell Line, Tumor; D004247:DNA / Q000378:metabolism; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D054856:G-Quadruplexes; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry; D007364:Intercalating Agents / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D008958:Models, Molecular; D011804:Quinolines / Q000737:chemistry; D011806:Quinolinium Compounds / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D052160:Benzothiazoles; D005456:Fluorescent Dyes; D026121:Indole Alkaloids; D007364:Intercalating Agents; D011804:Quinolines; D011806:Quinolinium Compounds; C024015:cryptolepine; D004247:DNA; C005465:benzothiazole