title: Final adult height in children with congenital adrenal hyperplasia treated with growth hormone.
abstract: BACKGROUND
  Patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency typically reach a final adult height well below their mid-parental target height.
  
  
  OBJECTIVE
  The objective of this study was to examine whether GH alone or in combination with an LHRH analog (LHRHa) improved the final adult height in patients with CAH.
  
  
  METHODS
  The study was a nonrandomized prospective study.
  
  
  METHODS
  The study was conducted at two university hospitals in New York City, NY.
  
  
  METHODS
  Thirty-four patients with CAH treated with GH participated in this study. Nineteen males and 15 females who were predicted to be more than 2 SD below their mid-parental target height or more than 2 SD below the population mean received GH until reaching final adult height. In addition to GH, 27 patients (16 males, 11 females) were also treated with an LHRHa.
  
  
  METHODS
  The mean duration of GH treatment was 5.6 ± 1.8 yr in males and 4.5 ± 1.6 yr in females. The mean duration of LHRHa therapy was 3.7 ± 1.7 yr for both sexes.
  
  
  METHODS
  The primary endpoint variables were final adult height, final height discrepancy, and gain in height.
  
  
  RESULTS
  Males reached a significantly higher final adult height (172.0 ± 4.8 cm) than their initial predicted height (162.8 ± 7.7 cm) (P < 0.00001). Females also reached a significantly higher final adult height (162.2 ± 5.3 cm) than initially predicted (151.7 ± 5.2 cm) (P < 0.0000001). Mean gain in height was 9.2 ± 6.7 cm in males and 10.5 ± 3.7 cm in females.
  
  
  CONCLUSIONS
  Our results indicate that GH alone or in combination with LHRHa improves final adult height in patients with CAH.
authors: Department of Pediatric Endocrinology, Weill Medical College of Cornell University, New York, New York 10021, USA.
authors: Karen
authors: K
authors: Lin-Su
authors: Madeleine D
authors: MD
authors: Harbison
authors: Oksana
authors: O
authors: Lekarev
authors: Maria G
authors: MG
authors: Vogiatzi
authors: Maria I
authors: MI
authors: New
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000503:physiopathology* / Q000628:therapy*; D000328:Adult; D001827:Body Height / Q000502:physiology*; D002648:Child; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D018579:Patient Selection; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone; D007987:Gonadotropin-Releasing Hormone