title: A new three-component reaction: green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α.
abstract: Concurrent construction of five and six membered fused N-heretocyclic ring was achieved via a conceptually new three-component reaction affording 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones as novel inhibitors of TNF-αin vitro. This represents one of the few examples of direct TNF-α inhibition by small molecules.
authors: Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad, 500049, India.
authors: K Siva
authors: KS
authors: Kumar
authors: P Mahesh
authors: PM
authors: Kumar
authors: K Anil
authors: KA
authors: Kumar
authors: M
authors: M
authors: Sreenivasulu
authors: Ahamed A
authors: AA
authors: Jafar
authors: D
authors: D
authors: Rambabu
authors: G Rama
authors: GR
authors: Krishna
authors: C Malla
authors: CM
authors: Reddy
authors: Ravikumar
authors: R
authors: Kapavarapu
authors: K
authors: K
authors: Shivakumar
authors: K Krishna
authors: KK
authors: Priya
authors: Kishore V L
authors: KV
authors: Parsa
authors: Manojit
authors: M
authors: Pal
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D015415:Biomarkers; D055772:Green Chemistry Technology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D054833:Isoindoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011799:Quinazolines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D006571:Heterocyclic Compounds; D054833:Isoindoles; D011799:Quinazolines; D014409:Tumor Necrosis Factor-alpha