title: A systematic review of economic evaluations of therapy in asthma.
abstract: BACKGROUND
  Asthma's cost-effectiveness is a major consideration in the evaluation of its treatment options. Our objective was to perform a systematic review of the cost-effectiveness of asthma medications.
  
  
  METHODS
  We performed a systematic search of MEDLINE, EMBASE, CINAHL, Cochrane Database of Systematic Reviews, OHE-HEED, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Health Technology Assessments Database, NHS Economic Evaluation Database, and Web of Science and reviewed references from key articles between 1990 and Jan 2008.
  
  
  RESULTS
  A total of 49 RCTs met the inclusion criteria. Maintenance therapy with inhaled corticosteroids was found to be very cost-effective and in uncontrolled asthmatics patients currently being treated with ICS, the combination of an ICS/LABA represents a safe, cost-effective treatment. The simplified strategy using budesonide and formoterol for maintenance and reliever therapy was also found to be as cost-effective as salmeterol/fluticasone plus salbutamol. Omalizumab was found to be cost-effective. An important caveat with regard to the published literature is the relatively high proportion of economic evaluations which are funded by the manufacturers of specific drug treatments.
  
  
  CONCLUSIONS
  Future studies should be completed independent of industry support and ensure that the comparator arms within studies should include dosages of drugs that are equivalent.
authors: Centre for Clinical Epidemiology and Evaluation (C2E2).
authors: Katayoun
authors: K
authors: Bahadori
authors: Bradley S
authors: BS
authors: Quon
authors: Mary M
authors: MM
authors: Doyle-Waters
authors: Carlo
authors: C
authors: Marra
authors: J Mark
authors: JM
authors: Fitzgerald