title: [Superficial siderosis of the central nervous system in a patient with hemochromatosis and Wilson's disease].
abstract: METHODS
  A 55-year-old patient with a history of Wilson's disease and biopsy proven hemochromatosis complained of hearing loss, vertigo, and gait disturbance. Clinical examination confirmed hearing loss, revealed cerebellar syndrome and bilateral pyramidal tract disturbances.
  
  
  METHODS
  Neurophysiology confirmed pathological findings on clinical examination. Cerebral magnetic resonance imaging (MRI) disclosed deposition of hemosiderin suggestive for superficial siderosis of the central nervous system. Cerebrospinal fluid findings were normal.
  
  
  METHODS
  The triad of hearing loss, cerebellar syndrome, and pyramidal tract disturbances associated with typical findings on MRI led to diagnosis of superficial siderosis.
  
  
  METHODS
  Etiology in this case remained unclear; no source of bleeding was detected. Thus, no causal therapeutic option was available.
  
  
  CONCLUSIONS
  A unique case of superficial siderosis in a patient with a history of Wilson's disease and hemochromatosis is presented. Unexpected new symptoms in a successfully treated Wilson's disease patient require further diagnostic work-up not to miss potentially curable differential diagnoses. Thus, regular neurological follow-up visits of Wilson's disease patients are required.
authors: Klinik für Neurologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf. clemens.warnke@med.uni-duesseldorf.de
authors: C
authors: C
authors: Warnke
authors: K
authors: K
authors: Andersen
authors: H-P
authors: HP
authors: Hartung
authors: H
authors: H
authors: Hefter
mesh_terms: D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000235:genetics; D015897:Comorbidity; D006432:Hemochromatosis / Q000175:diagnosis* / Q000235:genetics; D000071020:Hemochromatosis Protein; D006486:Hemosiderosis / Q000175:diagnosis* / Q000235:genetics; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008578:Meninges / Q000473:pathology; D008875:Middle Aged; D009460:Neurologic Examination; D011712:Pyramidal Tracts / Q000473:pathology
chemical_list: C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins