title: Phase II clinical study of boron neutron capture therapy combined with X-ray radiotherapy/temozolomide in patients with newly diagnosed glioblastoma multiforme--study design and current status report.
abstract: Recently, we reported our clinical experiences of boron neutron capture therapy (BNCT) for the newly diagnosed glioblastoma. The major differences of our protocol from the other past studies were simultaneous use of both sodium borocapate and boronophenylalanine, and combination with fractionated X-ray irradiation. These results showed the efficacy of combination therapy with external beam X-ray irradiation and BNCT. For our future study, we planned the multi-centric phase II clinical study for newly diagnosed glioblastoma patients in Japan (OSAKA-TRIBRAIN0902, NCT00974987).
authors: Department of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, Japan. neu046@poh.osaka-med.ac.jp
authors: Shinji
authors: S
authors: Kawabata
authors: Shin-Ichi
authors: S
authors: Miyatake
authors: Ryo
authors: R
authors: Hiramatsu
authors: Yuki
authors: Y
authors: Hirota
authors: Shiro
authors: S
authors: Miyata
authors: Yoko
authors: Y
authors: Takekita
authors: Toshihiko
authors: T
authors: Kuroiwa
authors: Mitsunori
authors: M
authors: Kirihata
authors: Yoshinori
authors: Y
authors: Sakurai
authors: Akira
authors: A
authors: Maruhashi
authors: Koji
authors: K
authors: Ono
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005909:Glioblastoma / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D000077204:Temozolomide
chemical_list: D000970:Antineoplastic Agents; D003606:Dacarbazine; D000077204:Temozolomide