title: Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia.
abstract: Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity. In the present study we found that treatment with 5-HT and behavioral training produce biphasic changes in the expression of CREB2, a transcriptional repressor. An immediate increase in CREB2 protein was followed by a subsequent decrease. The effects of these treatments persist for at least 24 h and are observed in isolated sensory neurons. This study suggests that the dynamics of CREB2 expression could contribute to the consolidation of memory.
authors: Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, Texas 77030, USA.
authors: Rong-Yu
authors: RY
authors: Liu
authors: Shreyansh
authors: S
authors: Shah
authors: Leonard J
authors: LJ
authors: Cleary
authors: John H
authors: JH
authors: Byrne
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D001048:Aplysia; D001522:Behavior, Animal; D002478:Cells, Cultured; D003214:Conditioning, Classical / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D004558:Electric Stimulation / Q000379:methods; D007839:Functional Laterality; D017952:Ganglia, Invertebrate / Q000166:cytology; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D017711:Nonlinear Dynamics; D012333:RNA, Messenger / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000906:Antibodies; C097204:ApCREB2 protein, Aplysia californica; D017362:Cyclic AMP Response Element-Binding Protein; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins; D012701:Serotonin