title: A micro-PET/CT approach using O-(2-[18F]fluoroethyl)-L-tyrosine in an experimental animal model of F98 glioma for BNCT.
abstract: The present study focuses on a micro-PET/CT application to be used for experimental Boron Neutron Capture Therapy (BNCT), which integrates, in the same frame, micro-CT derived anatomy and PET radiotracer distribution. Preliminary results have demonstrated that (18)F-fluoroethyl-tyrosine (FET)/PET allows the identification of the extent of cerebral lesions in F98 tumor bearing rat. Neutron autoradiography and α-spectrometry on axial tissues slices confirmed the tumor localization and extraction, after the administration of fructose-boronophenylalanine (BPA). Therefore, FET-PET approach can be used to assess the transport, the net influx, and the accumulation of FET, as an aromatic amino acid analog of BPA, in experimental animal model. Coregistered micro-CT images allowed the accurate morphological localization of the radiotracer distribution and its potential use for experimental BNCT.
authors: CNR Institute of Clinical Physiology, Pisa, Italy. luca.menichetti@ifc.cnr.it
authors: L
authors: L
authors: Menichetti
authors: D
authors: D
authors: Petroni
authors: D
authors: D
authors: Panetta
authors: S
authors: S
authors: Burchielli
authors: Silva
authors: S
authors: Bortolussi
authors: M
authors: M
authors: Matteucci
authors: G
authors: G
authors: Pascali
authors: S
authors: S
authors: Del Turco
authors: A
authors: A
authors: Del Guerra
authors: S
authors: S
authors: Altieri
authors: P A
authors: PA
authors: Salvadori
mesh_terms: D000818:Animals; D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000532:radiotherapy*; D004195:Disease Models, Animal; D005910:Glioma / Q000532:radiotherapy*; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D051381:Rats; D014057:Tomography, X-Ray Computed; D014443:Tyrosine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: C117289:O-(2-fluoroethyl)tyrosine; D014443:Tyrosine