title: Recurrent high-dose intravenous methylprednisolone succinate pulse therapy-induced hepatopathy in a patient with multiple sclerosis.
abstract: OBJECTIVE
  We describe recurrent and reversible hepatopathy in a girl with multiple sclerosis (MS) after glucocorticoid pulse therapy, to point out the possibility that glucocorticoid may harm the liver.
  
  
  METHODS
  An 11-year-old girl with MS, who was treated with high-dose methylprednisolone succinate pulse therapy, developed elevation of liver enzymes. The episodes of hepatopathy occurred 1-5 weeks after the therapy and disappeared within several weeks. The examination for antinuclear antibody and viruses which can cause hepatitis produced negative results.
  
  
  CONCLUSIONS
  The present case emphasizes the possible effects of high-dose glucocorticoids in the induction of liver enzymes and the importance of follow-up liver tests after pulse therapy.
authors: First Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan. in1110@poh.osaka-med.ac.jp
authors: Daisuke
authors: D
authors: Furutama
authors: Fumiharu
authors: F
authors: Kimura
authors: Keiichi
authors: K
authors: Shinoda
authors: Tamaki
authors: T
authors: Maeda
authors: Toshifumi
authors: T
authors: Tanaka
authors: Nakaaki
authors: N
authors: Ohsawa
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology*; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008111:Liver Function Tests; D008776:Methylprednisolone Hemisuccinate / Q000008:administration & dosage / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000188:drug therapy*; D020551:Pulse Therapy, Drug; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D008776:Methylprednisolone Hemisuccinate