title: Protective effect of low serum thyroid hormone concentration on occurrence of functional delayed kidney allograft function early after transplantation.
abstract: BACKGROUND
  Thyroid hormones affect the functioning of a number of organs and may alter kidney function. In contrast, the thyroid gland may be influenced by renal dysfunction. The present study evaluated triiodothyronine (T3), thyroxine, and thyroid-stimulating hormone concentrations before and early after transplantation relative to the occurrence of delayed graft function.
  
  
  METHODS
  Eighty-seven consecutive patients (52 male and 37 female patients) undergoing kidney transplantation were entered in this cross-sectional study, and T3, thyroxine, and thyroid-stimulating hormone concentrations were measured on the day before transplantation and on days 1, 3, and 7 after engraftment.
  
  
  RESULTS
  The mean (SD) serum T3 concentration was significantly greater before transplantation in patients with delayed graft function compared with those with normally functioning kidney allografts (129±31.44 ng/dL versus 102±36.77 ng/dL; P-value=.048). Lower T3 concentration values were predictive of delayed graft function. It was hypothesized that early after transplantation, in patients with uremia, a low T3 concentration confers a protective effect against ischemia-reperfusion injury, mitigating a hypercatabolic state.
  
  
  CONCLUSIONS
  Low serum T3 concentration in patients with uremia before transplantation may have protective effects against the hypercatabolic uremic state and ischemia-reperfusion injury early after engraftment.
authors: Mashhad University of Medical Sciences, Ghaem Hospital, Department of Nephrology, Mashhad, Iran. drhekmatreza@yahoo.com
authors: R
authors: R
authors: Hekmat
authors: Z
authors: Z
authors: Javadi
authors: M L
authors: ML
authors: Javain
authors: S
authors: S
authors: Bonakdaran
mesh_terms: D003430:Cross-Sectional Studies; D051799:Delayed Graft Function / Q000503:physiopathology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D015427:Reperfusion Injury / Q000517:prevention & control; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014184:Transplantation, Homologous; D014284:Triiodothyronine / Q000097:blood; D014511:Uremia / Q000097:blood* / Q000150:complications
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine