title: Photosensitive controlled release with polyethylene glycol-anthracene modified alginate.
abstract: Covalent modification of alginate with polyethylene glycol-conjugated anthracene molecules has the potential to both stabilize the alginate and act as a photosensitive crosslinker. Release studies with Coomassie Blue show lengthy release times from the alginate photogels that extend past 70 days with, for example, 17% versus 27% release at 1750 h (73 days) for photogels with and without 365-nm UV light treatment for 30 min at 10 mW/cm(2) in the initial release period. Photocrosslinking of the photogels after loading effectively "locks" in drug compounds to control their release. Effective crosslinking densities and controls of polyethylene glycol-crosslinked alginate and physically crosslinked calcium alginate gels suggest strong interactions between Coomassie Blue and both alginate and anthracene. Photogels containing anthracene-capped star-polyethylene glycol show increased photosensitivity with modified release profiles. Ultimately, the covalent modification of alginate with photoactive crosslinkers has the potential to produce a long-term, photosensitive, controlled release system.
authors: Department of Chemical Engineering, McMaster University, Hamilton, Canada.
authors: L A
authors: LA
authors: Wells
authors: H
authors: H
authors: Sheardown
mesh_terms: D000464:Alginates / Q000737:chemistry* / Q000528:radiation effects*; D000873:Anthracenes / Q000737:chemistry* / Q000528:radiation effects*; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000528:radiation effects; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry / Q000528:radiation effects; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000528:radiation effects*; D012394:Rosaniline Dyes / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D000464:Alginates; D000873:Anthracenes; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D012394:Rosaniline Dyes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; C048139:Coomassie blue; C034020:anthracene