title: Next-generation association studies for complex traits.
abstract: A new study successfully applies complementary whole-genome sequencing and imputation approaches to establish robust disease associations in an isolated population. This strategy is poised to help elucidate the role of variants at the low end of the allele frequency spectrum in the genetic architecture of complex traits.
authors: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. eleftheria@sanger.ac.uk
authors: Eleftheria
authors: E
authors: Zeggini
mesh_terms: D000483:Alleles; D024722:Cardiac Myosins / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D018995:Myosin Heavy Chains / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012804:Sick Sinus Syndrome / Q000235:genetics
chemical_list: C094239:MYH6 protein, human; D024722:Cardiac Myosins; D018995:Myosin Heavy Chains