title: Regulation of Foxo-dependent transcription by post-translational modifications.
abstract: The Forkhead Box O (Foxo) proteins represent an evolutionarily conserved family of transcription factors that play an important role in regulating processes including metabolism, longevity, and cell death/survival. How is it that a single transcription factor can initiate such divergent cellular responses? We will review the evidence that specific patterns of post-translational modifications play a key role in directing Foxo into various transcriptional readouts. This regulation appears to take on a two tiered regulatory model; with a group of well defined post-translational modifications regulating nuclear localization and transcriptional activity while a second set of modifications regulate the transcriptional specificity of Foxo.
authors: Department of Pediatrics, Division of Neurology, Abramson Research Center, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. Boccitto@mail.med.upenn.edu
authors: Marco
authors: M
authors: Boccitto
authors: Robert G
authors: RG
authors: Kalb
mesh_terms: D000107:Acetylation; D000818:Animals; D016923:Cell Death; D002470:Cell Survival; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation / Q000502:physiology; D011499:Protein Processing, Post-Translational; D054875:Ubiquitination / Q000502:physiology
chemical_list: D051858:Forkhead Transcription Factors