title: Early post-transplantation positron emission tomography in patients with Hodgkin lymphoma is an independent prognostic factor with an impact on overall survival.
abstract: The aim of the present study was to investigate the prognostic role of pre- and/or early post-autologous stem cell transplantation (ASCT) (18)F-flourodeoxyglucose (FDG) positron emission tomography (PET) in patients with relapsed/refractory Hodgkin lymphoma. Forty-three consecutive patients were enrolled in this study. FDG-PET/CT was performed following salvage chemotherapy within 6 weeks of undergoing ASCT and at the first month after ASCT. FDG-PET positivity was found in 26 patients before ASCT and in 13 patients after ASCT. The patients who had negative PET scan before or after ASCT had significantly better outcomes in terms of overall survival (OS) and progression-free survival (PFS). Pre- and post-ASCT FDG-PET positivity was found to be independently associated with PFS while post-ASCT FDG-PET was an independent factor with an impact on OS in multivariate analysis. (18)F-flourodeoxyglucose positron emission tomography imaging may be useful in predicting prognosis after ASCT. Furthermore, effective treatment options including allogeneic stem cell transplantation might be considered in patients with positive FDG-PET scan after salvage chemotherapy and ASCT.
authors: Department of Hematology, School of Medicine, Gazi University, Beşevler, 06500 Ankara, Turkey. aysucak@gazi.edu.tr
authors: Gülsan Türköz
authors: GT
authors: Sucak
authors: Zübeyde Nur
authors: ZN
authors: Özkurt
authors: Elif
authors: E
authors: Suyani
authors: Demet Gökalp
authors: DG
authors: Yaşar
authors: Özgür Ümit
authors: ÖÜ
authors: Akdemir
authors: Zeynep
authors: Z
authors: Aki
authors: Zeynep Arzu
authors: ZA
authors: Yeğin
authors: Münci
authors: M
authors: Yağci
authors: Özlem Lütfiye
authors: ÖL
authors: Kapucu
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D016879:Salvage Therapy / Q000379:methods; D015996:Survival Rate; D014182:Transplantation, Autologous; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D019788:Fluorodeoxyglucose F18