title: Photopigments in central serous chorioretinopathy.
abstract: OBJECTIVE
  To investigate functional abnormalities in eyes with central serous chorioretinopathy (CSC).
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  Sixteen eyes with CSC were enrolled. Autofluorescence densitometry was performed to measure the optical density of the photopigments. Serial fundus autofluorescence (FAF) images were obtained by Heidelberg Retina Angiogram 2. We calculated the autofluorescence optical density difference from the FAF images. To compare the distribution pattern of autofluorescence optical density difference to the findings of outer retina, spectral-domain optical coherence tomography (SD-OCT) was performed in the acute phase and after resolution of CSC.
  
  
  RESULTS
  The autofluorescence optical density difference decreased at the serous retinal detachment (SRD) in all 16 eyes. After resolution, the photoreceptor inner and outer segment junction (IS/OS) was irregular in 13 eyes and defective in 3 eyes on SD-OCT. The autofluorescence optical density difference did not improve in any eyes. Five eyes were reexamined 3 month after resolution. In 4 of the 5 eyes, SD-OCT showed that the IS/OS was well delineated and 1 eye defective. The autofluorescence optical density difference improved in 2 of the 4 eyes, but not in the other 2 eyes. In the 1 eye without well-delineated IS/OS, the autofluorescence optical density difference did not improve.
  
  
  CONCLUSIONS
  In eyes with CSC, the photopigment density decreased at the SRD. The density remained decreased immediately after resolution and showed delayed recovery. The photopigments decreased even in eyes with morphologic recovery of the outer retina.
authors: Department of Ophthalmology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Japan. ao@fmu.ac.jp
authors: Akira
authors: A
authors: Ojima
authors: Tomohiro
authors: T
authors: Iida
authors: Tetsuju
authors: T
authors: Sekiryu
authors: Ichiro
authors: I
authors: Maruko
authors: Yukinori
authors: Y
authors: Sugano
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D003720:Densitometry; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology; D012163:Retinal Detachment / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D012168:Retinal Pigments / Q000378:metabolism*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
chemical_list: D012168:Retinal Pigments