title: A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution.
abstract: Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, we hypothesize that a treatment combining radiotherapy with aerosol inhalation of a hydrogen-rich solution may be an effective and novel prevention strategy for radiation pneumonitis (hydrogen is explosive, while a hydrogen-rich solution such as physiological saline saturated with molecular hydrogen is safer).<br />
authors: Department of Radiation Medicine, Faculty of Naval Medicine, 2nd Military Medical University, Shanghai, PR China.
authors: Yunhai
authors: Y
authors: Chuai
authors: Luqian
authors: L
authors: Zhao
authors: Jin
authors: J
authors: Ni
authors: Ding
authors: D
authors: Sun
authors: Jianguo
authors: J
authors: Cui
authors: Bailong
authors: B
authors: Li
authors: Liren
authors: L
authors: Qian
authors: Fu
authors: F
authors: Gao
authors: Jianming
authors: J
authors: Cai
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage*; D006801:Humans; D006859:Hydrogen / Q000008:administration & dosage*; D008954:Models, Biological; D017564:Radiation Pneumonitis / Q000517:prevention & control* / Q000532:radiotherapy*; D012996:Solutions
chemical_list: D000336:Aerosols; D012996:Solutions; D006859:Hydrogen