title: Viral suppressors of RNA silencing.
abstract: The infection and replication of viruses in the host induce diverse mechanisms for combating viral infection. One of the best-studied antiviral defence mechanisms is based on RNA silencing. Consistently, several viral suppressors of RNA silencing (VSRs) have been identified from almost all plant virus genera, which are surprisingly diverse within and across kingdoms, exhibiting no obvious sequence similarities. VSRs efficiently inhibit host antiviral responses by interacting with the key components of cellular silencing machinery, often mimicking their normal cellular functions. Recent findings have revealed that the impact of VSRs on endogenous pathways is more complex and profound than had been estimated thus far. This review highlights the current understanding of and new insights into the mechanisms and functions of plant VSRs.
authors: Istituto di Virologia Vegetale, CNR, Strada Delle Cacce 73, Torino, Italy. J.Burgyan@ivv.cnr.it
authors: József
authors: J
authors: Burgyán
authors: Zoltán
authors: Z
authors: Havelda
mesh_terms: D015967:Gene Expression Regulation, Viral; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D008954:Models, Biological; D010935:Plant Diseases / Q000276:immunology / Q000821:virology*; D057865:Plant Immunity; D010942:Plant Viruses / Q000235:genetics / Q000472:pathogenicity*; D010944:Plants / Q000235:genetics / Q000276:immunology / Q000821:virology*; D034622:RNA Interference / Q000276:immunology*; D012367:RNA, Viral / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins; D037521:Virulence Factors