title: Desmoplastic small cell tumor with bizarre giant nuclei.
abstract: A case is reported of an intra-abdominal desmoplastic small cell tumor featuring giant bizarre nuclei, an event not previously recorded in this entity to the best of the authors' knowledge. The diagnosis was confirmed by immunohistochemistry and molecular genetics. A list is provided of the many other conditions in which this morphologically spectacular but clinically inconsequential nuclear change has been recorded.
authors: University of Milano-Bicocca, Monza, Italy. polletta.79@libero.it
authors: Francesca
authors: F
authors: Bono
authors: Maria Adele
authors: MA
authors: Testi
authors: Juan
authors: J
authors: Rosai
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002467:Cell Nucleus / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D058405:Desmoplastic Small Round Cell Tumor / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism; D014178:Translocation, Genetic / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C106032:EWS1-WT1 fusion protein, human; D015514:Oncogene Proteins, Fusion