title: Role of 12-week resistance training in preserving the heart against ischemia-reperfusion-induced injury.
abstract: BACKGROUND
  Discovering an effective approach to provide cardioprotection against coronary artery disease has long been sought. We studied the cardioprotective effect of resistance training against ischemia-reperfusion-induced injury.
  
  
  METHODS
  Twenty male rats were divided into trained and sedentary groups (n = 10 in each). The rats were exercised in squat-training apparatus (12 repetitions/set, four sets/day and five days/week for 12 weeks). After the last training session, transient regional ischemia of left anterior descending coronary artery (40 min) was followed by 80 min of reperfusion. Coronary flow, left ventricular developed pressure, diastolic pressure and infarct size were measured.
  
  
  RESULTS
  After 35 min of ischemia, coronary flow and developed pressure were higher in trained than untrained groups (10.37 ± 0.96 vs 7.54 ± 0.89 mL/min × g, p < 0.01 for coronary flow and 67.74 ± 3.31 vs 52.39 ± 4.28 mm Hg, p < 0.01 for developed pressure) and this difference persisted until 50 min of reperfusion (10.59 ± 0.88 vs 7.71 ± 0.73 mL/ /min × g, p < 0.01 for coronary flow and 58.12 ± 4.07 vs 39.56 ± 3.79 mm Hg, p < 0.01 for developed pressure). Diastolic pressure was significantly lower from 35 min of ischemia (11.51 ± 5.37 vs 24.53 ± 5.44 mm Hg, p < 0.05) through 35 min of reperfusion in trained rather than sedentary rats (30.62 ± 3.19 vs 43 ± 7.11 mm Hg, p < 0.01). Resistance exercise training reduced the infarct size statistically in trained rats as compared with sedentary animals (39.32 ± 4.09 vs 29.36 ± 4.17 percentage of zone at risk, p < 0.05).
  
  
  CONCLUSIONS
  These results show that chronic resistance exercise provides cardioprotection against myocardial injuries.
authors: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Soufifg@tbzmed.ac.ir
authors: Farhad Ghadiri
authors: FG
authors: Soufi
authors: Mohaddeseh Mahmoudi
authors: MM
authors: Saber
authors: Rafigheh
authors: R
authors: Ghiassie
authors: Mohsen
authors: M
authors: Alipour
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000503:physiopathology* / Q000628:therapy*; D003326:Coronary Circulation / Q000502:physiology; D004195:Disease Models, Animal; D006321:Heart / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology* / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D055070:Resistance Training / Q000379:methods*; D040242:Risk Reduction Behavior; D057185:Sedentary Behavior; D017725:Ventricular Pressure / Q000502:physiology