title: Interactions of renin-angiotensin system gene polymorphisms and antihypertensive effect of benazepril in Chinese population.
abstract: OBJECTIVE
  Angiotensin-converting enzyme inhibitors are widely used antihypertensive drugs with individual response variation. We studied whether interactions of AGT, AGTR1 and ACE2 gene polymorphisms affect this response.
  
  
  METHODS
  Our study is based on a 3-year field trial with 1831 hypertensive patients prescribed benazepril. Generalized multifactor dimensionality reduction was used to explore interaction models and logistic regressions were used to confirm them.
  
  
  RESULTS
  A two-locus model involving the AGT and ACE2 genes was found in males, the sensitive genotypes showed an odds ratio (OR) of 1.9 (95% CI: 1.3-2.8) when compared with nonsensitive genotypes. Two AGT-AGTR1 models were found in females, with an OR of 3.5 (95% CI: 2.0-5.9) and 3.1 (95% CI: 1.8-5.3).
  
  
  CONCLUSIONS
  Gender-specific gene-gene interactions of the AGT, AGTR1 and ACE2 genes were associated with individual variation of response to benazepril. Further studies are needed to confirm this finding.
authors: Department of Epidemiology & Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, PR China.
authors: Qing
authors: Q
authors: Chen
authors: Can-Qing
authors: CQ
authors: Yu
authors: Xun
authors: X
authors: Tang
authors: Da-Fang
authors: DF
authors: Chen
authors: Jun
authors: J
authors: Tian
authors: Yang
authors: Y
authors: Cao
authors: Wen-Yi
authors: WY
authors: Fan
authors: Wei-Hua
authors: WH
authors: Cao
authors: Si-Yan
authors: SY
authors: Zhan
authors: Jun
authors: J
authors: Lv
authors: Xiao-Xia
authors: XX
authors: Guo
authors: Yong-Hua
authors: YH
authors: Hu
authors: Li-Ming
authors: LM
authors: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000085962:Angiotensin-Converting Enzyme 2; D000808:Angiotensinogen / Q000037:antagonists & inhibitors / Q000235:genetics; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D044466:Asian People / Q000235:genetics*; D001552:Benzazepines / Q000627:therapeutic use*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000235:genetics*
chemical_list: C534931:AGT protein, human; C544065:AGTR1 protein, human; D000959:Antihypertensive Agents; D001552:Benzazepines; D044140:Receptor, Angiotensin, Type 1; D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2; C044946:benazepril