title: 19F MRI oximetry: simulation of perfluorocarbon distribution impact.
abstract: In (19)F MRI oximetry, a method used to image tumour hypoxia, perfluorocarbons serve as oxygenation markers. The goal of this study is to evaluate the impact of perfluorocarbon distribution and concentration in (19)F MRI oximetry through a computer simulation. The simulation studies the correspondence between (19)F measured (pO(FNMR)(2)) and actual tissue oxygen tension (pO(2)) for several tissue perfluorocarbon distributions. For this, a Krogh tissue model is implemented which incorporates the presence of perfluorocarbons in blood and tissue. That is, in tissue the perfluorocarbons are distributed homogeneously according to Gaussian diffusion profiles, or the perfluorocarbons are concentrated in the capillary wall. Using these distributions, the oxygen tension in the simulation volume is calculated. The simulated mean oxygen tension is then compared with pO(FNMR)(2), the (19)F MRI-based measure of pO(2) and with pO(0)(2), pO(2) in the absence of perfluorocarbons. The agreement between pO(FNMR)(2) and actual pO(2) is influenced by vascular density and perfluorocarbon distribution. The presence of perfluorocarbons generally gives rise to a pO(2) increase in tissue. This effect is enhanced when perfluorocarbons are also present in blood. Only the homogeneous perfluorocarbon distribution in tissue with no perfluorocarbons in blood guarantees small deviations of pO(FNMR)(2) from pO(2). Hence, perfluorocarbon distribution in tissue and blood has a serious impact on the reliability of (19)F MRI-based measures of oxygen tension. In addition, the presence of perfluorocarbons influences the actual oxygen tension. This finding may be of great importance for further development of (19)F MRI oximetry.
authors: Department of Radiation Oncology and Experimental Cancer Research, Ghent University, De Pintelaan 185, 9000 Gent, Belgium. steven.baete@ugent.be
authors: S H
authors: SH
authors: Baete
authors: J
authors: J
authors: Vandecasteele
authors: Y
authors: Y
authors: De Deene
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D003198:Computer Simulation; D004058:Diffusion; D005462:Fluorine Radioisotopes; D005466:Fluorocarbons / Q000737:chemistry / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D009369:Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D009374:Neoplasms, Experimental; D009389:Neovascularization, Pathologic / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology; D010092:Oximetry / Q000379:methods*; D010101:Oxygen Consumption; D011877:Radionuclide Imaging; D051381:Rats; D012680:Sensitivity and Specificity
chemical_list: D005462:Fluorine Radioisotopes; D005466:Fluorocarbons