title: Imatinib resistance and blast transformation of chronic myeloid leukemia associated with a novel tri-nucleotide insertion mutation of BCR-ABL kinase domain at position K294.
authors: Veera Sekaran
authors: VS
authors: Nadarajan
authors: Chow-Hiang
authors: CH
authors: Ang
authors: Mohamed Kamil
authors: MK
authors: Syed-Sultan
authors: Ping-Chong
authors: PC
authors: Bee
mesh_terms: D000293:Adolescent; D001549:Benzamides; D004252:DNA Mutational Analysis; D019008:Drug Resistance, Neoplasm; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D008213:Lymphocyte Activation / Q000235:genetics*; D008297:Male; D016254:Mutagenesis, Insertional; D010879:Piperazines / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D016044:Fusion Proteins, bcr-abl