title: Reduction of acethylcolinesterase activity in the brain of mdx mice.
abstract: Lack of dystrophin in brain structures have been involved with impaired cognitive functions. Acethylcolinesterase (AChE) is implicated in many cognitive functions and probably plays important roles in neurodegenerative disorders. In the present study, we investigated AChE activity in the prefrontal cortex, hippocampus, striatum and cortex of mdx mice. To this aim, brain tissues from male dystrophic mdx and normal control mice were used. We observed that mdx mice display a reduction in AChE activity of 40-60% in all brain structures evaluated. In conclusion, dystrophin deficiency may be affecting AChE activity and contributing negatively, in part, to memory storage and restoring.
authors: Laboratory of Neurosciences and National Institute for Translational Medicine (INCT-TM), Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil.
authors: Clarissa M
authors: CM
authors: Comim
authors: Thais
authors: T
authors: Moraz
authors: Igor
authors: I
authors: Abreu
authors: Daiane B
authors: DB
authors: Fraga
authors: Fernando V
authors: FV
authors: Ghedim
authors: Natália
authors: N
authors: Mildner
authors: Lisiane
authors: L
authors: Tuon
authors: Mariz
authors: M
authors: Vainzof
authors: Alexandra I
authors: AI
authors: Zugno
authors: João
authors: J
authors: Quevedo
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000473:pathology; D004195:Disease Models, Animal; D016189:Dystrophin / Q000172:deficiency; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics; D008297:Male; D051379:Mice; D018101:Mice, Inbred mdx; D009136:Muscular Dystrophies / Q000473:pathology*
chemical_list: D016189:Dystrophin; D000110:Acetylcholinesterase