title: Epithelial integrins with special reference to oral epithelia.
abstract: Adhesion of epithelium to the extracellular matrix is crucial for the maintenance of systemic and oral health. In the oral cavity, teeth or artificial dental implants penetrate the soft tissue of the gingiva. In this interface, gingival soft tissue needs to be well attached via the epithelial seal to the tooth or implant surface to maintain health. After injury or wounding, epithelial tissue rapidly migrates to form the initial epithelial cover to restore the barrier against infection. These events are crucially dependent on deposition of extracellular matrix and proper activation and function of integrin receptors in the epithelial cells. Recent experimental evidence suggests that epithelial integrins also participate in the regulation of periodontal inflammation. In this review, we will discuss the structure and function of epithelial integrins and their extracellular ligands and elaborate on their potential role in disease and repair processes in the oral cavity.
authors: Laboratory of Periodontal Biology, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. larjava@interchange.ubc.ca
authors: H
authors: H
authors: Larjava
authors: L
authors: L
authors: Koivisto
authors: L
authors: L
authors: Häkkinen
authors: J
authors: J
authors: Heino
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D004846:Epithelial Attachment / Q000166:cytology / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D039161:Integrin alpha6beta4 / Q000378:metabolism; D016023:Integrins / Q000737:chemistry / Q000502:physiology*; D015603:Keratinocytes / Q000737:chemistry / Q000502:physiology*; D009061:Mouth Mucosa / Q000737:chemistry* / Q000166:cytology; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*
chemical_list: D016326:Extracellular Matrix Proteins; D039161:Integrin alpha6beta4; D016023:Integrins; D053773:Transforming Growth Factor beta1