title: Dual stimuli-responsive polymeric micelles exhibiting "AND" logic gate for controlled release of adriamycin.
abstract: A new controlled release polymer micelle was designed and synthesized based on the concept of the "AND" logic with two orthogonal molecular triggers, namely pH and reduction, for intracellular drug delivery. Specifically, a hydrazine functionalized PEO-b-PMAA block copolymer was used to attach adriamycin (ADR) through the formation of hydrazone, then the as-prepared ADR-conjugated block copolymer micelles could be crosslinked by dithiodiethanoic acid. ADR was found to release most efficiently under both the low pH and the reductive conditions. This smart device is therefore equipped with two triggers with the "AND" logic for the releasing action, which is suitable for more complicated physiological conditions because the "ON" state is only realized under the simultaneous presence of the dual signal stimuli.
authors: Key Laboratory of Molecular Engineering of Polymers (Minister of Education), Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, 200433 People's Republic of China.
authors: Chuan
authors: C
authors: Wei
authors: Jia
authors: J
authors: Guo
authors: Changchun
authors: C
authors: Wang
mesh_terms: D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D008823:Micelles; D011108:Polymers; D011092:Polyethylene Glycols; D004317:Doxorubicin