title: The effect of pyrophosphate, tripolyphosphate and ATP on the rate of the Fenton reaction.
abstract: It has been recently reported that pyrophosphate, tri-polyphosphate, ATP and analogous ligands considerably decrease the yield of hydroxyl radicals by the Fenton reaction under conditions where [H(2)O(2)]>>[Fe(II)L(n)]. It was suggested that this effect is due to the slowing down of the Fenton reaction by these ligands. This suggestion seemed surprising as polyphosphate ligands stabilize Fe(III). Indeed, a kinetic study points out that these ligands accelerate the rate of the Fenton reaction by several orders of magnitude. Thus it is suggested that the effect of the ligands on the yield of the hydroxyl radicals is due to the stabilization of the Fe(III) complexes which slows down, or inhibits, their reduction by the radicals formed in the system and thus decreases the overall yield of hydroxyl radicals.
authors: Chemistry Department, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors: Sandra
authors: S
authors: Rachmilovich-Calis
authors: Alexandra
authors: A
authors: Masarwa
authors: Naomi
authors: N
authors: Meyerstein
authors: Dan
authors: D
authors: Meyerstein
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry* / Q000378:metabolism; D005290:Ferric Compounds / Q000737:chemistry / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000737:chemistry* / Q000378:metabolism; D017665:Hydroxyl Radical / Q000737:chemistry / Q000378:metabolism; D007501:Iron / Q000737:chemistry*; D007700:Kinetics; D008024:Ligands; D008958:Models, Molecular; D011122:Polyphosphates / Q000737:chemistry* / Q000378:metabolism
chemical_list: C045076:Fenton's reagent; D005290:Ferric Compounds; D008024:Ligands; D011122:Polyphosphates; D017665:Hydroxyl Radical; D000255:Adenosine Triphosphate; D006861:Hydrogen Peroxide; D007501:Iron; C005692:triphosphoric acid