title: Application of cost-effectiveness analysis to demonstrate the potential value of companion diagnostics in chronic myeloid leukemia.
abstract: OBJECTIVE
  A cost-effectiveness analysis was performed to assess the potential value of companion diagnostics in supporting treatment decisions for dasatinib and nilotinib in chronic myeloid leukemia.
  
  
  METHODS
  A decision model was developed, and model inputs were taken from the literature and publicly available sources. The perspective of the healthcare sector in the Netherlands was used. Sensitivity and scenario analyses were performed to assess uncertainty in the results.
  
  
  RESULTS
  Companion diagnostics could improve health and reduce costs, despite the estimates being uncertain owing to limited evidence for comparative effectiveness between dasatinib and nilotinib. The results were sensitive to the cost of treatment, utility of progression and progression-free survival.
  
  
  CONCLUSIONS
  This case demonstrates the use of cost-effectiveness analysis at an early stage of health technology assessment to generate economic evidence for the use of companion diagnostics in treatment decisions and to support decision-making for their development.
authors: Institute for Medical Technology Assessment/Institute of Health Policy & Management, Erasmus University, Rotterdam, The Netherlands. gaultney@bmg.eur.nl
authors: Jennifer G
authors: JG
authors: Gaultney
authors: Enrique
authors: E
authors: Sanhueza
authors: Jeroen J
authors: JJ
authors: Janssen
authors: William K
authors: WK
authors: Redekop
authors: Carin A
authors: CA
authors: Uyl-de Groot
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D003362:Cost-Benefit Analysis; D000069439:Dasatinib; D003661:Decision Support Techniques; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000188:drug therapy*; D046228:Microarray Analysis / Q000191:economics*; D009426:Netherlands; D011494:Protein Kinases / Q000032:analysis*; D011743:Pyrimidines / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D014408:Biomarkers, Tumor; D011743:Pyrimidines; D013844:Thiazoles; D011494:Protein Kinases; C498826:nilotinib; D000069439:Dasatinib