title: Effects of ethanol on the osteogenesis around porous hydroxyapatite implants.
abstract: Alcohol consumption compromises bone tissue, and thus may either impair or stop the fixation and maintenance of osseointegrated implants. To evaluate the effects of 5% and 15% ethanol on bone neoformation around porous hydroxiapatite implants. Fifteen rats were separated into 3 groups of 5 animals each: control (CT); 5% alcohol (A); and 15% alcohol (AA). After four weeks of ethanol consumption, the rats received porous hydroxiapatite implants into surgically made cavities in the femur. After surgery, the animals continued to consume ethanol until day 90 of the experiment, when they were euthanised and their femurs removed for histological processing. Bone tissue was found around the ceramic specimens of all the animals. The largest volume of neoformed bone around ceramic specimens occurred in the CT group, and the smallest in the AA group, followed by the A group. It was concluded that ethanol consumption produced a negative effect on osteogenesis around hydroxyapatite implants. Even small doses, such as the 5% ethanol dilution can interfere with bone repair.
authors: Núcleo de Pesquisa em Farmacologia e Cirurgia Experimental, Laboratório de Fitofarmacologia, Universidade José do Rosário Vellano, Alfenas, MG, Brazil.
authors: C C
authors: CC
authors: Lima
authors: T D
authors: TD
authors: Silva
authors: L
authors: L
authors: Santos
authors: W R
authors: WR
authors: Nakagaki
authors: Y C S
authors: YC
authors: Loyola
authors: M C C
authors: MC
authors: Resck
authors: J A
authors: JA
authors: Camilli
authors: E A
authors: EA
authors: Soares
authors: J A D
authors: JA
authors: Garcia
mesh_terms: D000818:Animals; D018786:Bone Substitutes; D017886:Durapatite; D000431:Ethanol / Q000494:pharmacology*; D005269:Femur / Q000473:pathology / Q000601:surgery*; D008297:Male; D016348:Osseointegration / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects*; D016062:Porosity; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018786:Bone Substitutes; D000431:Ethanol; D017886:Durapatite