title: Metabolic myopathies: clinical features and diagnostic approach.
abstract: The rheumatologist is frequently called on to evaluate patients with complaints of myalgia, muscle cramps, and fatigue. The evaluation of these patients presents a diagnostic challenge given the nonspecific and intermittent nature of their complaints, often leading to inappropriate diagnostic testing. When these symptoms are associated with physical exertion, a metabolic myopathy should be suspected Although inflammatory myopathies may present with similar features, such a pattern should prompt a thorough evaluation for an underlying metabolic myopathy. This review discusses the most common causes of metabolic myopathies and reviews the current diagnostic options available to the clinician.
authors: Division of Pediatric Neurology, Department of Pediatrics, Duke University Medical Center, DUMC Box 3936, Durham, NC 27710, USA.
authors: Edward C
authors: EC
authors: Smith
authors: Areeg
authors: A
authors: El-Gharbawy
authors: Dwight D
authors: DD
authors: Koeberl
mesh_terms: D042241:Early Diagnosis; D006801:Humans; D052439:Lipid Metabolism Disorders; D008661:Metabolism, Inborn Errors; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D009135:Muscular Diseases / Q000175:diagnosis* / Q000378:metabolism