title: Dyslipidemia in an HIV-positive antiretroviral treatment-naive population in Dar es Salaam, Tanzania.
abstract: Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings. We performed a cross-sectional analysis in antiretroviral therapy (ART)-naive, non-fasting HIV-infected patients in Tanzania between November 2004 to June 2008. Robust linear regression modeling was performed. Lipid parameters were assessed in 12,513 patients [65% women; median (interquartile range) age, 36 (30-42) years; CD4 count, 143 (51-290) cells/mm]. Low high-density lipoprotein was prevalent in 67% and increased triglyceride in 28%. High triglyceride and low high-density lipoprotein levels were associated with low CD4 counts (P < 0.001). In this ART-naive Tanzanian population, dyslipidemia was highly prevalent and associated with advanced disease. The impact of ART on these changes requires further exploration.
authors: Harvard School of Public Health, Department of Nutrition, Boston, MA, USA. carmstr2@bidmc.harvard.edu
authors: Catharina
authors: C
authors: Armstrong
authors: Enju
authors: E
authors: Liu
authors: James
authors: J
authors: Okuma
authors: Donna
authors: D
authors: Spiegelman
authors: Chalamilla
authors: C
authors: Guerino
authors: Marina
authors: M
authors: Njelekela
authors: Steve
authors: S
authors: Grinspoon
authors: Wafaie
authors: W
authors: Fawzi
authors: Claudia
authors: C
authors: Hawkins
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D015995:Prevalence; D013636:Tanzania / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D019380:Anti-HIV Agents; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol