title: GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases.
abstract: Increasing evidence suggests that multiple genes in the human leukocyte antigen(HLA) regions play an important role in development of cancers and immunity disorders. However, the biological mechanisms of the HLA associations are not well understood. We recently conducted a survey of all genome-wide association studies (GWAS) with significant findings in the HLA regions and concluded that diseases such as cancer and immune disorders are more likely to be associated with genetic variants located in the HLA regions than other diseases. This finding is suggestive for testing a hypothesis of a common etiology of infectious tumors and other immunity diseases.
authors: Unit of Statistical Genomics, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland 20892, USA. kay1yao@mail.nih.gov
authors: Yin Yao
authors: YY
authors: Shugart
authors: Ying
authors: Y
authors: Wang
authors: Wei-Hua
authors: WH
authors: Jia
authors: Yi-Xin
authors: YX
authors: Zeng
mesh_terms: D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006680:HLA Antigens / Q000235:genetics* / Q000378:metabolism; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics* / Q000276:immunology / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000276:immunology / Q000821:virology; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000276:immunology / Q000821:virology
chemical_list: D006680:HLA Antigens