title: Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.
abstract: OBJECTIVE
  Sarcoidosis is a systemic inflammatory disease characterized by the formation of non-caseating granulomas, with varied clinical manifestations. The common etiology of sarcoidosis is uncertain, but it is thought to be triggered by an exogenous antigenic stimulus, such as some bacterial proteins. Toll-like receptors (TLRs) recognize microbial components and elicit innate as well as adaptive immune responses. It has been reported that polymorphisms in TLR2 might be important in a small group of Caucasian sarcoidosis patients. The present study aimed to establish whether these findings are relevant to the Japanese population.
  
  
  METHODS
  We genotyped 5 single-nucleotide polymorphisms (SNPs) in TLR2 and assessed the allelic diversity between 257 Japanese sarcoidosis patients and 193 Japanese healthy controls.
  
  
  RESULTS
  No significant differences in the frequency of TLR2 alleles and haplotypes in the sarcoidosis cases were found in comparison with the controls. However, marginal associations were observed for TLR2 at rs3804099 and rs3804100 in sarcoidosis patients with cutaneous manifestations.
  
  
  CONCLUSIONS
  Our results suggest that TLR2 polymorphisms are not significantly related to the pathogenesis of sarcoidosis in the Japanese population.
authors: Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
authors: Mayuki
authors: M
authors: Sato
authors: Tatsukata
authors: T
authors: Kawagoe
authors: Akira
authors: A
authors: Meguro
authors: Masao
authors: M
authors: Ota
authors: Yoshihiko
authors: Y
authors: Katsuyama
authors: Mami
authors: M
authors: Ishihara
authors: Kenichi
authors: K
authors: Namba
authors: Nobuyoshi
authors: N
authors: Kitaichi
authors: Shin-ichiro
authors: S
authors: Morimoto
authors: Toshikatsu
authors: T
authors: Kaburaki
authors: Yasutaka
authors: Y
authors: Ando
authors: Shinobu
authors: S
authors: Takenaka
authors: Shigeaki
authors: S
authors: Ohno
authors: Hidetoshi
authors: H
authors: Inoko
authors: Nobuhisa
authors: N
authors: Mizuki
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000235:genetics; D007564:Japan; D015810:Linkage Disequilibrium / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012507:Sarcoidosis / Q000150:complications / Q000235:genetics*; D051195:Toll-Like Receptor 2 / Q000235:genetics*
chemical_list: C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2