title: Development of a bioactive fiber with immobilized synthetic peptides designed from the active site of a beetle defensin.
abstract: The 9-mer peptides RLYLRIGRR and RLLLRIGRR were immobilized to amino-functionalized cotton fibers by a modification of the SPOT synthesis technique. The antibacterial activities of the peptide-immobilized cotton fibers against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) were investigated. Antibacterial assays revealed that these fibers inhibit the growth of MRSA and the antibacterial activities were maintained after washing and sterilization by autoclaving. The anticancer effect of the peptide-immobilized fiber was also investigated with mouse myeloma cells and human leukemia cells. These results indicate that these fibers have strong growth inhibition activity against bacteria and cancer cells.
authors: Industrial Technology Center of Wakayama Prefecture, Ogura 60, Wakayama, Wakayama, Japan. makoto-n@wakayama-kg.go.jp
authors: Makoto
authors: M
authors: Nakamura
authors: Takashi
authors: T
authors: Iwasaki
authors: Seiji
authors: S
authors: Tokino
authors: Ai
authors: A
authors: Asaoka
authors: Minoru
authors: M
authors: Yamakawa
authors: Jun
authors: J
authors: Ishibashi
mesh_terms: D000818:Animals; D020134:Catalytic Domain; D001517:Coleoptera / Q000378:metabolism*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D010455:Peptides