title: Quantitative analysis of liver function using superparamagnetic iron oxide- and Gd-EOB-DTPA-enhanced MRI: comparison with Technetium-99m galactosyl serum albumin scintigraphy.
abstract: OBJECTIVE
  To examine whether or not the parameters regarding the signal intensity of the liver parenchyma on superparamagnetic iron oxide (SPIO)- and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI are correlated with the parameters of Technetium-99m galactosyl serum albumin ((99m)Tc-GSA) scintigraphy.
  
  
  METHODS
  This retrospective study consisted of 55 and 33 patients who underwent SPIO- and Gd-EOB-DTPA-enhanced MRI in addition to (99m)Tc-GSA scintigraphy, respectively. For each patient, we calculated Pre R2* and Pre R2, which are equivalent to R2* (=1/T2*) and R2 (=1/T2) values of the liver parenchyma; ΔR2* and ΔR2, which represent differences in R2* and R2 values of the liver parenchyma before and after administration of SPIO; and the increase rates of both the liver-to-spleen signal intensity ratio (LSR) and the liver-to-major psoas muscle signal intensity ratio (LMR) on the hepatobiliary phase compared with the precontrast image. For (99m)Tc-GSA scintigraphy, the receptor index LHL15 and the blood clearance index HH15 were recorded.
  
  
  RESULTS
  Regression analysis showed a moderate correlation between Pre R2* and LHL15 (P<0.05). Mild to moderate correlations were also obtained between any combination of ΔR2* and ΔR2 on the one hand, and LHL15 and HH15 on the other (P<0.05). There were moderate correlations between any combination of increase rates of LSR and LMR on the one hand, and LHL15 and HH15 on the other (P<0.05-0.001).
  
  
  CONCLUSIONS
  Pre R2*, ΔR2*, ΔR2 and the increase rates of LSR and LMR could be used as quantitative indicators of liver function.
authors: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. anishie@radiol.med.kyushu-u.ac.jp
authors: Akihiro
authors: A
authors: Nishie
authors: Yasuhiro
authors: Y
authors: Ushijima
authors: Tsuyoshi
authors: T
authors: Tajima
authors: Yoshiki
authors: Y
authors: Asayama
authors: Kousei
authors: K
authors: Ishigami
authors: Daisuke
authors: D
authors: Kakihara
authors: Tomohiro
authors: T
authors: Nakayama
authors: Yukihisa
authors: Y
authors: Takayama
authors: Daisuke
authors: D
authors: Okamoto
authors: Koichiro
authors: K
authors: Abe
authors: Makoto
authors: M
authors: Obara
authors: Kengo
authors: K
authors: Yoshimitsu
authors: Hiroshi
authors: H
authors: Honda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D003911:Dextrans; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012044:Regression Analysis; D012189:Retrospective Studies; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C073590:gadolinium ethoxybenzyl DTPA; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; C065507:ferumoxides; D019786:Gadolinium DTPA; D016284:Technetium Tc 99m Pentetate