title: Association study of EP1 gene polymorphisms with suicide completers in the Japanese population.
abstract: BACKGROUND
  Both environmental and genetic factors have been reported to be involved in suicidal behaviors. Considerable evidence indicates that impulsive aggression is one of the important risk factors that contribute to suicide. A recent study has shown that prostaglandin E2 type 1 receptor (EP1) signaling regulates impulsive-aggressive behaviors in mice under both social and environmental stresses. To test the possible involvement of the EP1 gene in suicide, we carried out an association study of EP1 gene polymorphisms with suicide completers in the Japanese population.
  
  
  METHODS
  We studied 5 SNPs including one SNP in exon 2 (rs3745459) and four SNPs in the potential promoter region of the EP1 gene (rs3810255, rs3810254, rs3810253 and rs10416814) in 374 healthy control and 287 completed suicide victims using standard Taqman probe genotyping assays.
  
  
  RESULTS
  No significant differences of the genotypic distribution, allelic frequency or haplotype distribution between controls and suicide completers were found. Gender based analysis revealed that genotypic, allelic and haplotypic distributions of rs3810255, rs3810254, rs3810253 and rs10416814 SNPs were significantly different between the female control and female suicide groups, although the differences did not withstand correction for multiple comparisons.
  
  
  CONCLUSIONS
  We could not find an association of EP1 gene with suicide in the Japanese population. Because several SNPs in the promoter region of the EP1 gene were nominally significantly associated with suicide in the female, further studies with a larger sample size and different population are needed to confirm this result.
authors: Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
authors: Huxing
authors: H
authors: Cui
authors: Irwan
authors: I
authors: Supriyanto
authors: Tohru
authors: T
authors: Sasada
authors: Kyoichi
authors: K
authors: Shiroiwa
authors: Masaaki
authors: M
authors: Fukutake
authors: Osamu
authors: O
authors: Shirakawa
authors: Migiwa
authors: M
authors: Asano
authors: Yasuhiro
authors: Y
authors: Ueno
authors: Yasushi
authors: Y
authors: Nagasaki
authors: Akitoyo
authors: A
authors: Hishimoto
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D004247:DNA / Q000235:genetics; D003627:Data Interpretation, Statistical; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D058306:Receptors, Prostaglandin E, EP1 Subtype / Q000235:genetics*; D012727:Sex Characteristics; D013405:Suicide / Q000706:statistics & numerical data*
chemical_list: C545635:PTGER1 protein, human; D058306:Receptors, Prostaglandin E, EP1 Subtype; D004247:DNA