title: Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand.
abstract: Introduced to minimize open vial wastage, single-dose vaccine vials require more storage space and therefore may affect vaccine supply chains (i.e., the series of steps and processes involved in distributing vaccines from manufacturers to patients). We developed a computational model of Thailand's Trang province vaccine supply chain to analyze the effects of switching from a ten-dose measles vaccine presentation to each of the following: a single-dose measles-mumps-rubella vaccine (which Thailand is currently considering) or a single-dose measles vaccine. While the Trang province vaccine supply chain would generally have enough storage and transport capacity to accommodate the switches, the added volume could push some locations' storage and transport space utilization close to their limits. Single-dose vaccines would allow for more precise ordering and decrease open vial waste, but decrease reserves for unanticipated demand. Moreover, the added disposal and administration costs could far outweigh the costs saved from preventing open vial wastage.
authors: Public Health Computational and Operations Research (PHICOR), University of Pittsburgh, 200 Meyran Avenue, Suite 200, Pittsburgh, PA, USA. BYL1@pitt.edu
authors: Bruce Y
authors: BY
authors: Lee
authors: Tina-Marie
authors: TM
authors: Assi
authors: Korngamon
authors: K
authors: Rookkapan
authors: Diana L
authors: DL
authors: Connor
authors: Jayant
authors: J
authors: Rajgopal
authors: Vorasith
authors: V
authors: Sornsrivichai
authors: Shawn T
authors: ST
authors: Brown
authors: Joel S
authors: JS
authors: Welling
authors: Bryan A
authors: BA
authors: Norman
authors: Sheng-I
authors: SI
authors: Chen
authors: Rachel R
authors: RR
authors: Bailey
authors: Ann E
authors: AE
authors: Wiringa
authors: Angela R
authors: AR
authors: Wateska
authors: Anirban
authors: A
authors: Jana
authors: Willem G
authors: WG
authors: Van Panhuis
authors: Donald S
authors: DS
authors: Burke
mesh_terms: D003365:Costs and Cost Analysis; D004356:Drug Storage / Q000191:economics* / Q000706:statistics & numerical data; D006801:Humans; D022542:Measles-Mumps-Rubella Vaccine / Q000191:economics / Q000600:supply & distribution*; D008962:Models, Theoretical; D013785:Thailand
chemical_list: D022542:Measles-Mumps-Rubella Vaccine