title: Clinical trials for solid tumors using electrochemotherapy.
abstract: Chemotherapy is a standard treatment for a wide variety of cancers. However, response rates are usually low. In melanoma, for example, partial response rates range from 20-45 % with complete responses of less than 5% (1-4). The cell membrane can be a significant barrier for agents with an intracellular site of action. The inability to cross the cell membrane and enter the cell could lead to a low response rate. The effectiveness of these agents could be enhanced if combined with a procedure that increases the permeability of the cell membrane.
authors: Department of Surgery, College of Medicine, University of South Florida, Tampa, FL.
authors: R
authors: R
authors: Heller
authors: R
authors: R
authors: Gilbert
authors: M J
authors: MJ
authors: Jaroszeski