title: Mechanism based medicine in infancy: complex interplay between developmental pharmacology and pharmacogenetics.
abstract: Introduction of the available knowledge on pharmacogenetics very likely is one of the tools to close the gap between 'population' focused evidence based and 'individual' mechanism based medicine. However, besides pharmacogenetics, other covariates like age, renal function and/or co-medication should also be considered simultaneously when aiming for a 'tailored' pharmacotherapy. To illustrate this, we further extended the tramadol example used by Wilffert et al. to illustrate the complex interplay between developmental pharmacology and pharmacogenetics.
authors: Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. karel.allegaert@uz.kuleuven.ac.be
authors: Karel
authors: K
authors: Allegaert
mesh_terms: D000367:Age Factors; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D006801:Humans; D007223:Infant; D008657:Metabolic Clearance Rate / Q000187:drug effects / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010597:Pharmacogenetics / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D019389:Cytochrome P-450 CYP2D6