title: Investigating the in vitro drug release kinetics from controlled release diclofenac potassium-ethocel matrix tablets and the influence of co-excipients on drug release patterns.
abstract: The objective of the study was to formulate and evaluate controlled release polymeric tablets of Diclofenac Potassium for the release rate, release patterns and the mechanism involved in the release process of the drug. Formulations with different types and grades of Ethyl Cellulose Ether derivatives in several drug-to-polymer ratios (D:P) were compressed into tablets using the direct compression method. In vitro drug release studies were performed in phosphate buffer (pH 7.4) as dissolution medium by using USP Method-1 (Rotating Basket Method). Similarity factor f2 and dissimilarity factor f1 were applied for checking the similarities and dissimilarities of the release profiles of different formulations. For the determination of the release mechanism and drug release kinetics various mathematical/kinetic models were employed. It was found that all of the Ethocel polymers could significantly slow down the drug release rate with Ethocel FP polymers being the most efficient, especially at D:P ratios of 10:03 which lead towards the achievement of zero or near zero order release kinetics.
authors: Drug Delivery Research center, Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, Dera Ismail Khan (KPK), Pakistan.
authors: Shefaat Ullah
authors: SU
authors: Shah
authors: Kifayat Ullah
authors: KU
authors: Shah
authors: Asimur
authors: A
authors: Rehman
authors: Gul Majid
authors: GM
authors: Khan
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004008:Diclofenac / Q000008:administration & dosage* / Q000737:chemistry; D005079:Excipients / Q000008:administration & dosage*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives; D012995:Solubility; D013607:Tablets
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D013607:Tablets; D004008:Diclofenac; D065347:Hypromellose Derivatives; C013517:ethyl cellulose; D002482:Cellulose; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium