title: Stem cell response to multiwalled carbon nanotube-incorporated regenerated silk fibroin films.
abstract: Multiwalled carbon nanotubes (MWCNTs) are considered to be the ideal reinforcements for biorelated applications on account of their remarkable structural, mechanical and thermal properties. However, before MWCNTs can be incorporated into new and existing biomedical devices, their toxicity and biocompatibility need to be investigated thoroughly. In this study, regenerated silk fibroin/MWCNT nanocomposite films were prepared using a solvent system with pre-dispersed MWCNTs. Their biocompatibility was examined in vitro using human bone marrow stem cells. Scanning electron microscopy and a WST-1 assay demonstrated that the silk fibroin/MWCN film supported BMSC attachment and growth over 7 days in culture similar to the silk fibroin only film.
authors: Department of Polymer Science and Engineering, Inha University, Incheon 402-751, Korea.
authors: Se Youn
authors: SY
authors: Cho
authors: Young Soo
authors: YS
authors: Yun
authors: E Sle
authors: ES
authors: Kim
authors: Moon Suk
authors: MS
authors: Kim
authors: Hyoung-Joon
authors: HJ
authors: Jin
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation; D002470:Cell Survival / Q000187:drug effects; D005349:Fibroins / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013234:Stem Cells / Q000187:drug effects*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D005349:Fibroins