title: Lack of long-term behavioral alterations after early postnatal treatment with tropisetron: implications for developmental psychobiology.
abstract: The early postnatal period represents a critical time window for brain development. Transient Cajal-Retzius cells in layer I of the cortex play an important role in cortical lamination by modulating neuronal migration and maturation. Recent data have demonstrated that the 5-HT(3) receptor antagonist and alpha7 nicotinic receptor partial agonist tropisetron, acting via 5-HT(3) receptors expressed on Cajal-Retzius cells, can disturb the formation of cortical columns at perinatal stages. This process is thought to be involved in several neuropsychiatric disorders. Here we investigated the possible long-term behavioral effects of exposure to tropisetron at early postnatal stages in mice. We found that the administration of 1mg/kg, intraperitoneal (i.p.) tropisetron from postnatal days 2-12 (P2-P12) did not induce significant cognitive, schizophrenia-like or emotional alterations in tropisetron-treated animals as compared to controls, when tested in multiple behavioral assays. These results may be of relevance regarding the possible protracted deleterious neuropsychiatric effects of tropisetron during early life.
authors: Department for Psychiatry and Psychotherapy, RG Animal Models in Psychiatry, Central Institute of Mental Health Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany. Dragos.Inta@zi-mannheim.de
authors: Dragos
authors: D
authors: Inta
authors: Miriam A
authors: MA
authors: Vogt
authors: Juan M
authors: JM
authors: Lima-Ojeda
authors: Natascha
authors: N
authors: Pfeiffer
authors: Miriam
authors: M
authors: Schneider
authors: Peter
authors: P
authors: Gass
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D007211:Indoles / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D001523:Mental Disorders / Q000139:chemically induced / Q000523:psychology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012919:Social Behavior; D013997:Time Factors; D016896:Treatment Outcome; D000077526:Tropisetron
chemical_list: D007211:Indoles; D000077526:Tropisetron