title: Successful bone marrow transplantation in a pediatric patient with chronic myeloid leukemia from a HLA-identical sibling selected by preimplantation HLA testing.
abstract: We report successful bone marrow transplantation in an 11-year-old male with chronic myeloid leukemia from his HLA-identical sibling selected by preimplantation HLA testing. Because collection of cord blood failed, the transplantation was performed when the donor reached the age of 19 months, and sufficient bone marrow could be harvested safely. The patient was BCR/ABL negative at the time of transplantation after complete molecular response to imatinib. Currently, 16 months post-transplantation he is well and in complete molecular remission. This report describes preimplantation HLA-genotyping to deliver a matched sibling donor for successful transplantation of a malignant disorder.
authors: Stem Cell Transplant Unit, Aghia Sophia Children's Hospital, Thivon and Papadiamantopoulou, Athens, Greece. evgoussetis@gmail.com
authors: Evgenios
authors: E
authors: Goussetis
authors: Pantelis
authors: P
authors: Constantoulakis
authors: Vasiliki
authors: V
authors: Kitra
authors: Ioulia
authors: I
authors: Peristeri
authors: Minas
authors: M
authors: Mastrominas
authors: Margarita
authors: M
authors: Baka
authors: Miltiadis
authors: M
authors: Papadimitropoulos
authors: Christos
authors: C
authors: Karamolegos
authors: Anna
authors: A
authors: Paisiou
authors: Helen
authors: H
authors: Vasilatou-Kosmidis
authors: Stelios
authors: S
authors: Graphakos
mesh_terms: D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006085:Graft Survival; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000601:surgery*; D008297:Male; D011247:Pregnancy; D019836:Preimplantation Diagnosis; D035781:Siblings; D014019:Tissue Donors
chemical_list: D006680:HLA Antigens