title: [Significance of plasmic homocysteine, folate and Vitamin B(12) in ulcerative colitis].
abstract: OBJECTIVE
  To investigate the clinical significance of plasmic homocysteine (Hcy), folate (FA) and Vitamin B(12) (VitB(12)) in patients with ulcerative colitis (UC).
  
  
  METHODS
  Plasmic Hcy in 112 cases of UC patients and 110 controls were detected by HPLC-FD method. Plasmic FA, VitB(12) in 76 cases of UC patients and 12 controls were detected by enzyme-linked immunosorbent assay (ELISA) method.
  
  
  RESULTS
  The level of plasmic Hcy in UC patients was(11.27±7.26) μmol/L, significantly higher than that in controls[(8.19±4.81) μmol/L, P<0.05], and was not significantly correlated with disease index, extent and duration of UC(P>0.05). The level of FA and VitB(12) in UC patients were (7.64±1.95) nmol/L and (108.64±32.22) pmol/L respectively, lower than those in controls[(9.14±1.23) nmol/L and (112.64±33.33) pmol/L, P<0.05]. The level of plasmic Hcy was negatively correlated with the level of FA and VitB(12) in UC patients(P<0.05). The level of plasmic FA decreased to some extent with UC disease duration.
  
  
  CONCLUSIONS
  Plasmic Hcy is elevated in UC patients, which may be related to the decrease of FA and VitB(12).
authors: Department of Gastroenterology, The Frist Affiliated Hospital, Anhui Medical University, The Key Laboratory of Digestive Diseases of Anhui Province, Hefei 230022, China. meiqiaomq@yahoo.com.
authors: Mo-Li
authors: ML
authors: Chen
authors: Qiao
authors: Q
authors: Mei
authors: Jian-Ming
authors: JM
authors: Xu
authors: Nai-Zhong
authors: NZ
authors: Hu
authors: Chun-Xia
authors: CX
authors: Lu
authors: Hai-Ming
authors: HM
authors: Fang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000097:blood*; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014805:Vitamin B 12 / Q000097:blood*; D055815:Young Adult
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12