title: An anti-tumor nanoparticle, [Gd@C82(OH)22]n, induces macrophage activation.
abstract: [Gd@C82(OH)22]n, a fullerene-based nanoparticle, exhibits potent anti-tumor effects in mouse tumor-bearing models without detectable toxicity and the pathological studies revealed a massive infiltration of leukocytes in the residual tumors of [Gd@C82(OH)22]n-treated mice. We report here that [Gd@C82(OH)22]n promotes macrophages secreting pro-inflammatory cytokines IL-6 and TNF-alpha, enhances the expression of MHC-II and costimulatory molecules such as CD40 and CD54, increases endocytosis and cell adhesion. Furthermore, [Gd@C82(OH)22]n-treated macrophages became functionally activated as illustrated by their capacity to activate allogeneic T cells. Taken together, our results indicate that [Gd@C82(OH)22]n nanoparticle is a potent activator of macrophages, which may in part account for its potent anti-tumor effect.
authors: Tianjin Medical University Cancer Institute and Hospital, Central Laboratory of Oncology Department, Research Center of Basic Medical Sciences, Tianjin 300060, PR China.
authors: Bingbing
authors: B
authors: Wang
authors: De
authors: D
authors: Yang
authors: Baoyun
authors: B
authors: Sun
authors: Xiyin
authors: X
authors: Wei
authors: Hua
authors: H
authors: Guo
authors: Xiaoli
authors: X
authors: Liu
authors: Guoguang
authors: G
authors: Ying
authors: Ruifang
authors: R
authors: Niu
authors: Ning
authors: N
authors: Zhang
authors: Yongjie
authors: Y
authors: Ma
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology*; D037741:Fullerenes / Q000008:administration & dosage* / Q000276:immunology / Q000633:toxicity; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000008:administration & dosage* / Q000633:toxicity; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines; D037741:Fullerenes