title: Eight months of continuous positive airway pressure (CPAP) decrease tumor necrosis factor alpha (TNFA) in men with obstructive sleep apnea syndrome.
abstract: OBJECTIVE
  The aim of this study was to assess serum tumor necrosis factor alpha (TNFA) concentrations 8 months of continuous positive airway pressure (CPAP) therapy.
  
  
  METHODS
  This study used prospective, observational clinical trial.
  
  
  METHODS
  Sixty-six patients with newly diagnosed sleep apnea syndrome (12 women, 54 men), age 52.3 ± 9.8 (mean ± SD) with a body mass index of 29.7 ± 4.4 and an apnea-hypopnea index of 39.7 ± 26.8, were studied.
  
  
  METHODS
  CPAP was administered for a mean of 7.8 ± 1.3 months.
  
  
  RESULTS
  TNFA concentrations using an ultrasensitive ELISA assay at baseline and follow-up. TNFA decreased in men with high (5.2 ± 1.7 h/night, -0.46 ± 1.1 ng/l, p = 0.001) and with low (2.5 ± 1.0 h/night -0.63 ± 0.77 ng/l, p = 0.001) adherence but not in women. Average number of hours of CPAP use correlated positively with delta TNFA (R                            (2) 0.08, p = 0.04)
  
  
  CONCLUSIONS
  Long-term CPAP positively affects TNFA even in men with poor adherence to CPAP.
authors: Geriatrische Klinik, Kompetenzzentrum Gesundheit und Alter, St. Gallen, Switzerland.
authors: Andrea
authors: A
authors: Hegglin
authors: Otto D
authors: OD
authors: Schoch
authors: Wolfgang
authors: W
authors: Korte
authors: Kirsten
authors: K
authors: Hahn
authors: Christoph
authors: C
authors: Hürny
authors: Thomas
authors: T
authors: Münzer
mesh_terms: D050153:Abdominal Fat; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001823:Body Composition; D045422:Continuous Positive Airway Pressure; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D017286:Polysomnography; D011446:Prospective Studies; D012737:Sex Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy*; D013223:Statistics as Topic; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha