title: Hematologic and biochemical indices and viral hepatitis in liver transplant patients.
abstract: OBJECTIVE
  The pathogenic role of important hepatotropic viral agents to induce hepatic dysfunction and failure may lead to the need for liver transplantation. We focused on the use of hematologic and biochemical laboratory diagnostic indexes to follow the clinical impact of hepatitis B virus (HBV); hepatitis C virus (HCV); and hepatitis G virus-related liver complications in transplant patients.
  
  
  METHODS
  We collected 141 EDTA-treated blood samples pre- and post-liver transplantation for 2 years among 67 transplant patients. We evaluated the statistical relationships between hematologic and biochemical indices with HBV, HCV, and HGV infections among transplant recipient samples using version 15 of SPSS software.
  
  
  RESULTS
  HBV polymerase chain reaction (PCR) positivity significantly correlated with partial thromboplastin (P=.011) pretransplant, with creatinine (P=.026) and Na (P=.034) levels at 1-week posttransplant, and also with alkaline phosphatase (P=.027) and mean corpuscular hemoglobin concentration (P=.050) at 2 weeks posttransplantation. Significant correlations were detected between HCV-reverse transcriptase (RT)-PCR-positive results and blood urea nitrogen (P=.008) and Na (P=.021) levels in the first aspartate aminotransferase and with (P=.025) in the second week after liver transplantation. Also, significant relationships were noted between HGV-RT-PCR-positive results and alkaline phosphatase (P=.05) and creatinine (P=.002) levels in the first and second weeks after liver transplant, respectively.
  
  
  CONCLUSIONS
  Detection of significant correlations between HBV, HCV, and HGV infections with laboratory indices suggested that monitoring hematologic and biochemical liver function-related criteria aid the management of clinical complications of viral hepatitis in liver transplant patients.
authors: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Nemazee Hospital, Shiraz, Iran.
authors: M
authors: M
authors: Nemayandeh
authors: R
authors: R
authors: Yaghobi
authors: B
authors: B
authors: Geramizadeh
authors: M
authors: M
authors: Ayatollahi
authors: S A
authors: SA
authors: Malek-Hosseini
authors: S
authors: S
authors: Nikeghbalian
authors: H
authors: H
authors: Salahi
authors: A
authors: A
authors: Bahador
authors: M H
authors: MH
authors: Karimi
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D029407:GB virus C / Q000235:genetics; D016174:Hepacivirus / Q000235:genetics; D006509:Hepatitis B / Q000150:complications / Q000378:metabolism*; D006515:Hepatitis B virus / Q000235:genetics; D006526:Hepatitis C / Q000150:complications / Q000378:metabolism*; D006801:Humans; D016030:Kidney Transplantation; D008099:Liver / Q000473:pathology; D017093:Liver Failure / Q000628:therapy* / Q000821:virology; D016031:Liver Transplantation / Q000379:methods*; D011183:Postoperative Complications; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012984:Software
chemical_list: D003404:Creatinine; D000469:Alkaline Phosphatase