title: High-risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer.
abstract: BACKGROUND
  The purpose of this study was to determine the role of high-risk human papillomavirus (HPV) in lymph node metastasis and the depth of invasion in oropharyngeal cancer.
  
  
  METHODS
  The study included patients with 90 oral carcinomas and 66 oropharyngeal carcinomas. High-risk HPV in situ hybridization was performed to detect HPV infection.
  
  
  RESULTS
  The positive rate of high-risk HPV in situ hybridization was 15.4% (24 of 156). There was a significant difference in the fraction of positive high-risk HPV between oral (6.7%) and oropharyngeal (27.3%) cancers (p < .000). Significant correlations were found between positive high-risk HPV and cervical lymph node metastasis, tumor depth of invasion in patients with oropharyngeal cancer (p = .002, p = .016, respectively). There was a statistically significant association between high-risk HPV positivity and the disease-specific survival in patients with oropharyngeal cancer (p = .035).
  
  
  CONCLUSIONS
  High-risk HPV infection was significantly related to cervical lymph node metastasis and depth of invasion in patients with oropharyngeal cancer. © 2011 Wiley Periodicals, Inc. Head Neck, 2012.
authors: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, St. Mary's Hospital, The Catholic University of Korea, Seoul.
authors: Young-Hoon
authors: YH
authors: Joo
authors: Chan-Kwon
authors: CK
authors: Jung
authors: Dong-Il
authors: DI
authors: Sun
authors: Jun-Ook
authors: JO
authors: Park
authors: Kwang-Jae
authors: KJ
authors: Cho
authors: Min-Sik
authors: MS
authors: Kim
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D017403:In Situ Hybridization; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology*; D008207:Lymphatic Metastasis; D008297:Male; D009062:Mouth Neoplasms / Q000473:pathology* / Q000821:virology; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000473:pathology* / Q000821:virology; D027383:Papillomaviridae / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000150:complications* / Q000175:diagnosis; D012307:Risk Factors; D016019:Survival Analysis