title: Cytogenetic analysis of telomere dysfunction.
abstract: Dysfunctional telomeres arising either through natural attrition due to telomerase deficiency or by the removal of telomere binding proteins are recognized as double stranded breaks (DSBs). Repair of DSBs is crucial for the maintenance of genome stability. In mammals, DSBs are repaired by either error prone nonhomologous end joining (NHEJ) or error free homologous recombination (HR) and can be visualized as chromosomal fusions.
authors: Department of Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
authors: Asha S
authors: AS
authors: Multani
authors: Sandy
authors: S
authors: Chang
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D020732:Cytogenetic Analysis / Q000379:methods*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D011995:Recombination, Genetic; D016615:Telomere / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*