title: Prediction of fasting gastric pH using serum biological markers.
abstract: OBJECTIVE
  Previous studies have suggested that hypochlorhydria has the potential to produce adverse effects such as the development of infections of the intestinal or respiratory tract and impaired drug absorption. This indicates the importance of obtaining a noninvasive method by which this condition may be diagnosed. The purpose of this study was to determine whether fasting gastric pH could be predicted noninvasively using serum biological markers.
  
  
  METHODS
  One hundred thirty-two patients undergoing diagnostic upper gastrointestinal endoscopy were recruited. Serum levels of pepsinogen-I, pepsinogen-II and Helicobacter pylori antibody were analyzed and the pH of fasting gastric juice determined. Multiple linear regression analysis was used to determine the best predictors of fasting gastric pH.
  
  
  RESULTS
  Pepsinogen-I and the presence of Helicobacter pylori were independent predictors of fasting gastric pH, and a high coefficient of determination was obtained (R2 = 0.503, root mean square error = 1.45). The equation for this model was as follows: fasting gastric pH = 2.97-0.026 (pepsinogen-I)+2.76 (presence of Helicobacter pylori: 0=absent, 1=present).
  
  
  CONCLUSIONS
  The model equation offers a noninvasive method by which to identify patients at high-risk of developing complications induced by hypochlorhydria.
authors: Department of Gastroenterology, Tokyo Dental College, Ichikawa General Hospital, 5-11-13 Sugano Ichikawa, Chiba 272-8513, Japan. kisikawa@tdc.ac.jp
authors: Hiroshi
authors: H
authors: Kishikawa
authors: Jiro
authors: J
authors: Nishida
authors: Hitoshi
authors: H
authors: Ichikawa
authors: Shogo
authors: S
authors: Kaida
authors: Takashi
authors: T
authors: Matsukubo
authors: Soichiro
authors: S
authors: Miura
authors: Tetsuo
authors: T
authors: Morishita
authors: Toshifumi
authors: T
authors: Hibi
mesh_terms: D000126:Achlorhydria / Q000150:complications*; D015415:Biomarkers / Q000097:blood*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005750:Gastric Juice / Q000737:chemistry*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007074:Immunoglobulin G / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D020115:Pepsinogen C / Q000097:blood*; D011237:Predictive Value of Tests; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G; D020115:Pepsinogen C; D020116:Pepsinogen A