title: Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer.
abstract: BACKGROUND
  Caspase-8 (CASP8) and caspase-9 (CASP9) play crucial roles in regulating apoptosis, and their functional polymorphisms may alter cancer risk. Our aim was to investigate the association of CASP8 and CASP9 gene polymorphisms with gastric cancer (GC) susceptibility.
  
  
  METHODS
  We undertook a case-control study of 88 GC cases and 480 controls to investigate the association between CASP8 -652 6N ins/del and CASP9 -1263 A>G polymorphisms and GC susceptibility by a polymerase chain reaction (PCR)-restriction fragment length polymorphism method.
  
  
  RESULTS
  CASP8 -652 6N ins/del polymorphism and CASP9 -1263 GG genotype were observed to be significantly associated with a reduced risk of GC. No significant association was observed between CASP8 -652 6N ins/del and CASP9 -1263 A>G polymorphisms and tumor characteristics. However, both CASP8 del/del and CASP9 -1263 GG genotypes were associated with increased overall survival in GC patients.
  
  
  CONCLUSIONS
  The CASP8 -652 6N ins/del and the CASP9 -1263 A>G polymorphisms were observed to play a protective role in GC predisposition.
authors: 1st Surgical Department, Tzaneion Hospital, Piraeus, Greece.
authors: Emmanouil
authors: E
authors: Liamarkopoulos
authors: Maria
authors: M
authors: Gazouli
authors: Gerasimos
authors: G
authors: Aravantinos
authors: Nikolaos
authors: N
authors: Tzanakis
authors: George
authors: G
authors: Theodoropoulos
authors: Spyros
authors: S
authors: Rizos
authors: Nikolaos
authors: N
authors: Nikiteas
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics*; D053453:Caspase 9 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality
chemical_list: C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053181:Caspase 8; D053453:Caspase 9