title: The role of arterial embolization in controlling pelvic fracture haemorrhage: a systematic review of the literature.
abstract: OBJECTIVE
  To evaluate the efficacy of emergency transcatheter arterial embolization (TAE) in controlling retroperitoneal arterial haemorrhage associated with unstable pelvic fractures.
  
  
  METHODS
  A systematic review of the English literature yielded 21 eligible studies published from 1979 to 2010. Evaluation of clinical and methodological heterogeneity was based on recording certain descriptive characteristics in the component studies. Statistical heterogeneity was detected using Cochran chi-square and I square tests and, when absent, a pooled estimate of effect size for each outcome of interest was calculated. The principal outcomes of interest were efficacy rate of TAE to control intrapelvic bleeding, mortality rates and frequency of associated complications.
  
  
  RESULTS
  All component studies were assigned a low to moderate quality score. Methodological and clinical heterogeneity was evident across component studies, but not strongly associated with the observed results. The efficacy rate of TAE ranged from 81 to 100%, while the frequency of repeat TAE for effective control of haemorrhage was 10% (95% CI: 7-13%, range: 0-19%). TAE was associated with an overall mortality ranging from 7 to 47%, and a 0-25% mortality due to intrapelvic bleeding (pooled estimate of effect size: 6%, 95% CI: 4-8%). A very low rate of associated complications were recorded in the component studies (pooled estimate of effect size: 1.1%, 95% CI: 0.1-2.1%).
  
  
  CONCLUSIONS
  TAE is an efficient acute intervention for controlling severe arterial bleeding related to pelvic trauma with a low complication rate. Repeat of the procedure is occasionally necessary before the effective haemorrhage control.
authors: Department of Trauma and Orthopaedics"G. Hatzikostas" General Hospital, Makriyianni Avenue, 45001 Ioannina, Greece. epappa@ioa.forthnet.gr
authors: Costas
authors: C
authors: Papakostidis
authors: Nikolaos
authors: N
authors: Kanakaris
authors: Rozalia
authors: R
authors: Dimitriou
authors: Peter V
authors: PV
authors: Giannoudis
mesh_terms: D015897:Comorbidity; D004621:Embolization, Therapeutic / Q000401:mortality*; D050723:Fractures, Bone / Q000453:epidemiology* / Q000628:therapy*; D006470:Hemorrhage / Q000401:mortality* / Q000517:prevention & control*; D006801:Humans; D010384:Pelvic Bones / Q000293:injuries*; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome