title: Prepregnancy obesity and sFlt1-induced preeclampsia in mice: developmental programming model of metabolic syndrome.
abstract: OBJECTIVE
  We sought to establish a model of fetal programming of metabolic syndrome by exposure to soluble fms-like tyrosine kinase-1 (sFlt1)-induced preeclampsia (PE) and preexisting maternal obesity (MO).
  
  
  METHODS
  CD-1 female mice were placed on either standard or high-fat diet for 3 months. On day 8 of pregnancy, mice were injected with either adenovirus-carrying sFlt1 or adenovirus-carrying murine immunoglobulin G2α Fc fragment. Offspring were studied at 6 months of age.
  
  
  RESULTS
  Exposure to MO with/without PE resulted in significant increase in progeny's weight and adiposity. Blood pressure in males was significantly increased due to MO with PE. Metabolic blood analytes were affected in males and females exposed to only PE or MO with/without PE; inflammatory-in females exposed to MO with/without PE and males born to MO with PE; atherosclerotic-in females exposed to MO.
  
  
  CONCLUSIONS
  Exposure to maternal prepregnancy obesity and sFlt1-induced preeclampsia alter the offspring's blood pressure, metabolic, inflammatory, and atherosclerotic profiles later in life.
authors: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, USA. egbytaut@utmb.edu
authors: Egle
authors: E
authors: Bytautiene
authors: Esther
authors: E
authors: Tamayo
authors: Talar
authors: T
authors: Kechichian
authors: Nathan
authors: N
authors: Drever
authors: Phyllis
authors: P
authors: Gamble
authors: Gary D V
authors: GD
authors: Hankins
authors: George R
authors: GR
authors: Saade
mesh_terms: D050154:Adiposity; D000818:Animals; D001794:Blood Pressure; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology / Q000378:metabolism*; D051379:Mice; D009765:Obesity / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000139:chemically induced / Q000378:metabolism*; D011247:Pregnancy; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000494:pharmacology*
chemical_list: D040281:Vascular Endothelial Growth Factor Receptor-1