title: [Expression and clinical significance of serum interleukin-8 level in patients with oral squamous cell carcinoma].
abstract: OBJECTIVE
  To explore the clinical significance of serum interleukin-8 (IL-8) level in patients with oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  Twenty-seven serum specimens pathologically confirmed as OSCC were tested,10 healthy serum specimens were used as control. The expression of serum IL-8 was measured by ELISA. Data was presented as mean ± standard error. Statistical analysis was performed by SPSS 13.0 software package and two-tailed independent sample t test was used to determine the difference between the two groups.
  
  
  RESULTS
  The level of serum IL-8 in OSCC patients was significantly higher than that in the control (P < 0.01). The high expression of IL-8 correlated with clinical pathologic stage (P < 0.01) and lymph node metastasis (P < 0.05).
  
  
  CONCLUSIONS
  The expression of serum IL-8 correlates significantly with the biological behavior of OSCC, and it can be used as a prognostic molecular marker for OSCC. Supported by the Third Session of Excellent Youth Foundation of Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.
authors: Department of Clinical Laboratory, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China. guwenli8@yahoo.com.cn
authors: Wen-li
authors: WL
authors: Gu
authors: Jia-jia
authors: JJ
authors: Yang
mesh_terms: D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell; D006801:Humans; D016209:Interleukin-8; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D016209:Interleukin-8