title: Studies of distribution and recurrence of Helicobacter spp. gastric mucosa of dogs after triple therapy.
abstract: OBJECTIVE
  To analyze the triple antimicrobial therapy in positive Helicobacter spp. dogs and to investigate recurrence.
  
  
  METHODS
  A total of 20 dogs underwent endoscopy followed by gastric biopsy using the rapid urease test and histopathology stained with Giemsa. Ten animals were treated with triple therapy recommended for humans and divided into control and experimental group. The control group was kept in isolation while the experimental group was placed in contact with positive animals during 60 days.
  
  
  RESULTS
  The prevalence of infection in animals in this experiment was 100%, and more frequent in the fundus and the gastric body. Therapy for 7 days using clarithromycin, amoxicillin and lansoprazole was effective in 100% of the animals. Recurrence of the infection in 80% of dogs in the experimental group, while the control group remained eradicated after 60 days.
  
  
  CONCLUSIONS
  Crowded environments associated with close contact with dogs infected with helicobacter are a determinant for transmission of Helicobacter spp. between canines.
authors: Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil. tpanacleto@gmail.com
authors: Thiago Pires
authors: TP
authors: Anacleto
authors: Luiz Roberto
authors: LR
authors: Lopes
authors: Nelson Adami
authors: NA
authors: Andreollo
authors: Walter Octaviano
authors: WO
authors: Bernis Filho
authors: Maria Cristina Costa
authors: MC
authors: Resck
authors: Adriano
authors: A
authors: Macedo
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D004285:Dogs; D004359:Drug Therapy, Combination / Q000379:methods; D005753:Gastric Mucosa / Q000382:microbiology*; D016998:Helicobacter / Q000302:isolation & purification*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D008795:Metronidazole / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000627:therapeutic use; D015995:Prevalence; D012008:Recurrence
chemical_list: D000890:Anti-Infective Agents; D009942:Organometallic Compounds; D008795:Metronidazole; D000658:Amoxicillin; C002791:bismuth tripotassium dicitrate