title: A paragonimiasis patient with allergic reaction to praziquantel and resistance to triclabendazole: successful treatment after desensitization to praziquantel.
abstract: Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimus westermani, who displayed an allergic reaction to praziquantel and resistance to triclabendazole treatment. The patient was successfully treated with praziquantel following a rapid desensitization procedure. Desensitization to praziquantel could be considered when no alternative drugs are available.
authors: Department of Medicine, Gachon University Gil Medical Center, Incheon 405-760, Korea.
authors: Sun Young
authors: SY
authors: Kyung
authors: Yong Kyun
authors: YK
authors: Cho
authors: Yu Jin
authors: YJ
authors: Kim
authors: Jeong-Woong
authors: JW
authors: Park
authors: Sung Hwan
authors: SH
authors: Jeong
authors: Jae-Ik
authors: JI
authors: Lee
authors: Yon Mi
authors: YM
authors: Sung
authors: Sang Pyo
authors: SP
authors: Lee
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008875:Middle Aged; D010237:Paragonimiasis / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology; D010238:Paragonimus / Q000302:isolation & purification / Q000502:physiology; D011223:Praziquantel / Q000009:adverse effects* / Q000276:immunology* / Q000627:therapeutic use; D016896:Treatment Outcome; D000077682:Triclabendazole
chemical_list: D001562:Benzimidazoles; D000077682:Triclabendazole; D011223:Praziquantel