title: Time-lag between subretinal fluid and pigment epithelial detachment reduction after polypoidal choroidal vasculopathy treatment.
abstract: OBJECTIVE
  The goal of the present research was to study post-treatment changes in polypoidal choroidal vasculopathy (PCV) shown by optical coherence tomography (OCT).
  
  
  METHODS
  The study included 12 patients with naive PCV. Photodynamic therapy and 3 consecutive intravitreal bevacizumab injections at 6-week intervals were given. Best corrected visual acuity, subretinal fluid (SRF), pigment epithelium detachment (PED), central macular thickness (CMT), and total macular volume (TMV) were measured before and after treatment as assessed by Stratus OCT3.
  
  
  RESULTS
  After treatment, the SRF height decreased earlier than the PED height. The SRF diameter decreased with statistical significance. However, the PED diameter did not show a statistically significant improvement, persisting at pre-treatment levels. Both CMT and TMV decreased significantly after treatment.
  
  
  CONCLUSIONS
  After PCV treatment, SRF and PED stabilized, as shown by OCT. However, the PED treatment response was both delayed and refractory compared to the SRF response. The small change in post-treatment PED diameter may suggest the possibility of PCV recurrence.
authors: Department of Ophthalmology, Chungbuk National University College of Medicine, Cheongju, Korea.
authors: Ju Byung
authors: JB
authors: Chae
authors: Joo Yong
authors: JY
authors: Lee
authors: Sung Jae
authors: SJ
authors: Yang
authors: June-Gone
authors: JG
authors: Kim
authors: Young Hee
authors: YH
authors: Yoon
mesh_terms: D000368:Aged; D002829:Choroid / Q000473:pathology*; D015862:Choroid Diseases; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy*; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D010778:Photochemotherapy / Q000009:adverse effects*; D011379:Prognosis; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D058471:Subretinal Fluid; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity