title: Recommendations for the use of genetic testing in the clinical evaluation of inherited cardiac arrhythmias associated with sudden cardiac death: Canadian Cardiovascular Society/Canadian Heart Rhythm Society joint position paper.
abstract: The era of gene discovery and molecular medicine has had a significant impact on clinical practice. Knowledge of specific genetic findings causative for or associated with human disease may enhance diagnostic accuracy and influence treatment decisions. In cardiovascular disease, gene discovery for inherited arrhythmia syndromes has advanced most rapidly. The arrhythmia specialist is often confronted with the challenge of diagnosing and managing genetic arrhythmia syndromes. There is now a clear need for guidelines on the appropriate use of genetic testing for the most common genetic conditions associated with a risk of sudden cardiac death. This document represents the first ever published recommendations outlining the role of genetic testing in various clinical scenarios, the specific genes to be considered for testing, and the utility of test results in the management of patients and their families.
authors: Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. mgollob@ottawaheart.ca
authors: Michael H
authors: MH
authors: Gollob
authors: Louis
authors: L
authors: Blier
authors: Ramon
authors: R
authors: Brugada
authors: Jean
authors: J
authors: Champagne
authors: Vijay
authors: V
authors: Chauhan
authors: Sean
authors: S
authors: Connors
authors: Martin
authors: M
authors: Gardner
authors: Martin S
authors: MS
authors: Green
authors: Robert
authors: R
authors: Gow
authors: Robert
authors: R
authors: Hamilton
authors: Louise
authors: L
authors: Harris
authors: Jeff S
authors: JS
authors: Healey
authors: Kathleen
authors: K
authors: Hodgkinson
authors: Christina
authors: C
authors: Honeywell
authors: Michael
authors: M
authors: Kantoch
authors: Joel
authors: J
authors: Kirsh
authors: Andrew
authors: A
authors: Krahn
authors: Michelle
authors: M
authors: Mullen
authors: Ratika
authors: R
authors: Parkash
authors: Damian
authors: D
authors: Redfearn
authors: Julie
authors: J
authors: Rutberg
authors: Shubhayan
authors: S
authors: Sanatani
authors: Anna
authors: A
authors: Woo
mesh_terms: D001145:Arrhythmias, Cardiac / Q000151:congenital / Q000175:diagnosis / Q000401:mortality; D002170:Canada / Q000453:epidemiology; D016757:Death, Sudden, Cardiac / Q000453:epidemiology / Q000209:etiology*; D005820:Genetic Testing / Q000592:standards*; D006801:Humans; D015994:Incidence; D017410:Practice Guidelines as Topic; D015203:Reproducibility of Results; D012955:Societies, Medical