title: Lack of cytomegalovirus and polyomavirus coexistence in Iranian kidney transplant recipients.
abstract: BACKGROUND
  Maintenance of kidney graft function is essential, averting infection and coinfection. Cytomegalovirus (CMV) and BK polyomavirus (BKV) coinfection have been reported. There are a few studies of CMV and BKV infection in kidney transplant recipients in Iran, but no studies of their coinfection.
  
  
  OBJECTIVE
  To assess the coexistence of CMV and BKV infection in renal transplant recipients.
  
  
  METHODS
  The presence of CMV and BKV was assessed using real-time polymerase chain reaction in a cross-sectional study in 91 renal transplant recipients at 1 month posttransplantation. Assessment of CMV was performed only in blood samples, whereas BKV was assessed in both serum and urine samples.
  
  
  RESULTS
  The 91 patients included 57 men (62.6%) and 34 women (37.4%), who ranged in age from 19 to 76 years. Simultaneous evaluation of CMV in plasma and BKV in urine demonstrated no significant association. Of 24 patients positive for BKV in urine, 8 (33.3%) were positive for CMV in plasma. Sixty-seven patients tested negative for BKV in urine, whereas 23 (34.4%) tested positive for CMV, which is unremarkable. Comparison of coinfection with plasma CMV and plasma BKV demonstrated no significant correlation. In 3 patients positive for BKV in plasma only, 1 (33.3%) was positive for CMV, whereas in 88 patients negative for BKV in plasma, 30 were positive for CMV.
  
  
  CONCLUSIONS
  No significant association was observed between CMV and BKV infections in kidney transplant recipients.
authors: Nephrology Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Nasiri_s@tums.ac.ir
authors: S
authors: S
authors: Nasiri
authors: S F
authors: SF
authors: Ahmadi
authors: M
authors: M
authors: Lessan-Pezeshki
authors: S
authors: S
authors: Seyfi
authors: S
authors: S
authors: Alatab
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003587:Cytomegalovirus / Q000378:metabolism*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D007492:Iran; D007676:Kidney Failure, Chronic / Q000150:complications*; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011120:Polyomavirus / Q000378:metabolism*; D027601:Polyomavirus Infections / Q000150:complications / Q000175:diagnosis; D014777:Virus Diseases / Q000150:complications*