title: Hepcidin is produced by lymphoplasmacytic cells and is associated with anemia in Waldenström's macroglobulinemia.
abstract: Waldenström's macroglobulinemia (WM) patients often present with anemia as their primary disease manifestation that may be related to hepcidin, an important regulator of iron homeostasis. We therefore determined hepcidin levels in 53 WM patients, and 20 age-matched healthy patient donors by hepcidin-25 ELISA. Serum hepcidin levels were elevated in WM patients versus healthy patients (P=.04), and correlated with BM disease involvement (P=.004), beta-2-microglobulin levels (P=.029), and inversely with hemoglobin (P=.05). No correlation with serum iron indices was observed, though in patients with high hepcidin levels, increased iron deposition in bone marrow macrophages was observed. Importantly, hepcidin transcripts and protein were produced by primary WM cells. Hepcidin levels correlated with serum IL-6 (P<.001) and C-Reactive Protein (P=.033) levels. The results of this study implicate hepcidin as a contributor to anemia in WM, and suggest that an iron re-utilization defect accompanies hepcidin overproduction leading to its sequestration in WM patients.
authors: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors: Bryan T
authors: BT
authors: Ciccarelli
authors: Christopher J
authors: CJ
authors: Patterson
authors: Zachary R
authors: ZR
authors: Hunter
authors: Christina
authors: C
authors: Hanzis
authors: Leukothea
authors: L
authors: Ioakimidis
authors: Robert
authors: R
authors: Manning
authors: Guang
authors: G
authors: Yang
authors: Lian
authors: L
authors: Xu
authors: Yangsheng
authors: Y
authors: Zhou
authors: Jenny
authors: J
authors: Sun
authors: Xia
authors: X
authors: Liu
authors: Hsiuyi
authors: H
authors: Tseng
authors: Yang
authors: Y
authors: Cao
authors: Patricia
authors: P
authors: Sheehy
authors: Scott J
authors: SJ
authors: Rodig
authors: Steven P
authors: SP
authors: Treon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood*; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D005260:Female; D064451:Hepcidins; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000378:metabolism; D008258:Waldenstrom Macroglobulinemia / Q000097:blood*
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins