title: An unusual case of identification by DNA analysis of siblings.
abstract: A badly decomposed body required identification by means of DNA analysis. A brother and sister of the deceased were available as reference subjects. Although investigation of Y-chromosomal markers established an exclusion condition, autosomal markers suggested a positive identification. In order to increase the reliability of the tests, X-chromosomal markers were also investigated. This analysis showed the body to have an XXY genotype (Klinefelter's syndrome). A number of hypotheses were assessed using biostatistical methods, ultimately resulting in a definite identification. The special aspect of Klinefelter's syndrome proved highly useful for biostatistical analysis.
authors: Institute of Legal Medicine, University of Salzburg, Ignaz-Harrer-Str. 79, A-5020, Austria. Franz.Neuhuber@sbg.ac.at
authors: Franz
authors: F
authors: Neuhuber
authors: Max P
authors: MP
authors: Baur
authors: Jan
authors: J
authors: Cemper-Kiesslich
authors: Bettina
authors: B
authors: Dunkelmann
authors: Fabio
authors: F
authors: Monticelli
mesh_terms: D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D005260:Female; D018732:Forensic Anthropology / Q000379:methods*; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010375:Pedigree; D035781:Siblings
chemical_list: D005819:Genetic Markers