title: Eight-year follow-up of a girl with McCune-Albright syndrome.
abstract: McCune-Albright syndrome (MAS) is characterized by the triad of fibrous dysplasia (FD), cafe-au-lait spots and precocious puberty (PP). We report a 14-year-old girl with MAS who has been followed-up for 8 years. She was referred for multiple fractures and vaginal bleeding at age 5.9 years. She had peripheral PP, FD, and osteoporosis and was diagnosed as MAS. The patient was treated with aromatase inhibitors and bisphosphonates. She had no menses during aromatase inhibitor treatment. Her growth rate and bone maturation were in normal ranges while on treatment. She had one new fracture on the seventh year of follow- up in spite of bisphosphonate treatment.
authors: Pediatric Endocrinologist, Dr. Sami Ulus Obstetrics and Gynecology, Childrens Health and Disease Training and Research Hospital, Department of Pediatric Endocrinology, Ankara, Turkey.
authors: Zehra
authors: Z
authors: Aycan
authors: Aşan
authors: A
authors: Önder
authors: Semra
authors: S
authors: Çetinkaya
mesh_terms: D000293:Adolescent; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D005500:Follow-Up Studies; D006801:Humans
chemical_list: D050071:Bone Density Conservation Agents