title: Induction of ezrin-radixin-moesin molecules after cryogenic traumatic brain injury of the mouse cortex.
abstract: Traumatic brain injury promotes rapid induction of microglial cells and infiltration of peripheral macrophages to the injury sites. Such inflammatory responses are mediated by the activation and migration of immune cells, which are influenced by the actin cytoskeleton remodeling. In this study, we observed that the phosphorylation and expressions of ezrin-radixin-moesin (ERM) proteins, which are linkers for cell surface with actin cytoskeleton, are induced in the activated microglia/macrophages, whereas ERM molecules are only marginally expressed in quiescent microglia in the normal brain. These results suggest that ERM activation in the injury penumbra is implicated in the inflammatory immune responses after traumatic brain injury.
authors: Department of Anatomy and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, Seoul, Korea.
authors: Younghye
authors: Y
authors: Moon
authors: Joo Yeon
authors: JY
authors: Kim
authors: So Yoen
authors: SY
authors: Choi
authors: Kyungjin
authors: K
authors: Kim
authors: Hyun
authors: H
authors: Kim
authors: Woong
authors: W
authors: Sun
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D003080:Cold Temperature / Q000009:adverse effects*; D003598:Cytoskeletal Proteins / Q000096:biosynthesis* / Q000235:genetics; D004195:Disease Models, Animal; D005911:Gliosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008262:Macrophage Activation / Q000235:genetics; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism; D017628:Microglia / Q000378:metabolism* / Q000473:pathology; D016192:Resting Phase, Cell Cycle / Q000235:genetics; D013997:Time Factors; D000099149:Ezrin
chemical_list: D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D000099149:Ezrin; C071058:moesin; C071776:radixin