title: Quantification of systemic interference in optical topography data during frontal lobe and motor cortex activation: an independent component analysis.
abstract: Functional near-infrared optical topography (OT) is used to non-invasively measure the changes in oxygenated and deoxygenated haemoglobin (Δ[HbO2], Δ[HHb]) and hence investigate the brain haemodynamic changes, which occur in response to functional activation at specific regions of the cerebral cortex. However, when analysing functional OT data the task-related systemic changes should be taken into account.Here we used an independent component analysis (ICA) method on the OT [HbO2] signal, to determine the task-related independent components and then compared them with the systemic measurements (blood pressure, heart rate, scalp blood flow) to assess whether the components are due to systemic noise or neuronal activation. This analysis can therefore extract the true OT haemodynamic neuronal response and hence discriminate between regional activated cortical areas and global haemodynamic changes.
authors: Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK.
authors: Sundeep
authors: S
authors: Patel
authors: Takusige
authors: T
authors: Katura
authors: Atsushi
authors: A
authors: Maki
authors: Ilias
authors: I
authors: Tachtsidis
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism*; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D009044:Motor Cortex / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism; D010108:Oxyhemoglobins / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen