title: [Cell-derived microparticules: key players at the crossroad between inflammation and thrombosis].
abstract: Cell-derived microparticles are complex vesicular structures that can be shedded by activated or apoptotic endothelial cells. Cell-derived microparticles are composed of a phospholipid bilayer that exposes transmembrane proteins and receptors and encloses cytosolic components such as enzymes, transcription factors and mRNA derived from their parent cells. Thus, they behave as biological conveyors playing a key role in the tuning of vascular homeostasis. This review will address the potential of microparticles as efficient vectors of biological activities in pathologies. Based on the model of endothelial vesiculation, the first part of this review will develop the contribution of endothelial microparticles to coagulation inflammation and angiogenesis and their role in vascular disorders. The second part will be focused on the multifaceted impact of cell-derived microparticles present in blood products and its relevance to transfusion medicine.
authors: Inserm UMR-S 608, UFR de pharmacie, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France. florence.sabatier@ap-hm.fr
authors: F
authors: F
authors: Sabatier
authors: R
authors: R
authors: Lacroix
authors: A-S
authors: AS
authors: Leroyer
authors: S
authors: S
authors: Cointe
authors: F
authors: F
authors: Dignat-George
mesh_terms: D001777:Blood Coagulation / Q000502:physiology; D001779:Blood Coagulation Factors / Q000502:physiology; D016913:Blood Component Transfusion; D001793:Blood Preservation; D001798:Blood Proteins / Q000502:physiology; D055252:Cell-Derived Microparticles / Q000737:chemistry / Q000502:physiology* / Q000637:transplantation; D042783:Endothelial Cells / Q000502:physiology / Q000648:ultrastructure; D006706:Homeostasis; D006801:Humans; D007165:Immunosuppression Therapy; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D018919:Neovascularization, Physiologic / Q000502:physiology; D010718:Phosphatidylserines / Q000097:blood; D013927:Thrombosis / Q000097:blood*; D014652:Vascular Diseases / Q000097:blood / Q000473:pathology
chemical_list: D001779:Blood Coagulation Factors; D001798:Blood Proteins; D010718:Phosphatidylserines