title: [Effects of medicated thread moxibustion of Zhuang medicine on sex hormone in ovariectomized rabbits].
abstract: OBJECTIVE
  To explore the mechanism of medicated thread moxibustion of Zhuang medicine (MTMZ) in treating perimenopausal period syndrome.
  
  
  METHODS
  Thirty rabbits were randomly divided into a normal group, a model group, a medicated thread group, a no-medicated thread group and a sham operation group, 6 cases in each group. The model of perimenopausal period syndrome was established by ovariectomizing the ovary. The medicated thread group was treated with MTMZ at "Qizhou" acupoint (Extra), "Xiaguanyuan"(Extra), "Shenshu" (BL 23) and "Pishu" (BL 20), etc., once each day for 4 weeks. The no-medicated thread group was treated with no-medicated thread moxibustion at the same acupoints, and there is no treatment in the other groups. The changes of hormone level in each group before and after the treatment were observed.
  
  
  RESULTS
  After ovariectomizing the ovary, the serum estradiol (E2) in the model group [(308.33 +/- 12.58) pmol/L], the medicated thread group [(304.96 +/- 13.85) pmol/L] and the no-medicated thread group [(303.43 +/- 10.57) pmol/L] were lower than that in the normal group [(478.09 +/- 12.23) pmol/L] and the sham operation group [(488.05 +/- 11.45) pmol/L] (all P < 0.01). After treatment, the E2 level in medicated thread group [(338.92 +/- 11.23) pmol/L] was higher than before (P < 0.01) and that in the model group [(300.53 +/- 13.68) pmol/L] and the no-medicated thread group [(309.74 +/- 13.59) pmol/L] (both P < 0.01), and the serum follicle stimulating hormone [FSH, (58.90 +/- 5.29) U/L] and luteinizing hormone [LH, (64.65 +/- 5.23) U/L] were lower than those in the model group [(65.41 +/- 5.19) U/L], [(71.85 +/- 5.30) U/L] (both P < 0.05).
  
  
  CONCLUSIONS
  MTMZ can increase the serum E2 and reduce the serum FSH and LH in ovariectomized rabbits, and this may be one of the mechanisms of MTMZ for treatment of perimenopausal period syndrome.
authors: Ruikang Clinical Medical College Affiliated to Guangxi College of TCM, Nanning 530001, China. Ymchun2004@yahoo.com.cn
authors: Mei-Chun
authors: MC
authors: Yang
authors: Li-Juan
authors: LJ
authors: Han
authors: Jing
authors: J
authors: Li
authors: Gang
authors: G
authors: Fang
authors: Xia-Qing
authors: XQ
authors: Xiao
mesh_terms: D000818:Animals; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008516:Medicine, Chinese Traditional; D008593:Menopause; D009071:Moxibustion / Q000379:methods*; D010052:Ovariectomy; D011817:Rabbits; D011897:Random Allocation
chemical_list: D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone