title: Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives.
abstract: This study examines the synthesis and antibacterial activities of 5,7-dihydroxycoumarin derivatives, whose structures were confirmed using analytical and spectral data. Twenty compounds were tested for their antibacterial activities against five microbial species such as E. coli, S. aureus, K. pneumonia, P. aeruginosa, and S. typhimurium were studied. Compounds 5 and 12 exhibited the most potent activity against Staphylococcus aureus with a MIC value of 2.5 µg/mL for each of the compounds.
authors: Department of Microbiology and Immunology, Taipei Medical University, Taiwan, ROC.
authors: Yi-Ping
authors: YP
authors: Chin
authors: Wei-Jan
authors: WJ
authors: Huang
authors: Feng-Lin
authors: FL
authors: Hsu
authors: Yuh-Ling
authors: YL
authors: Lin
authors: Mei-Hsiang
authors: MH
authors: Lin
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins