title: Increased risk of preterm birth among women with mitral valve prolapse: a nationwide, population-based study.
abstract: OBJECTIVE
  Using nationwide population-based databases, we aimed to assess the association between mitral valve prolapse (MVP) and adverse pregnancy outcomes.
  
  
  METHODS
  The Taiwan Birth Registry and the National Health Insurance Research Dataset were used for analysis. Of all pregnant women in Taiwan who had singleton births in 2005, we identified a total of 3104 mothers diagnosed with MVP during ambulatory or emergency care visits, together with 12,245 mothers unaffected by MPV. Multivariate logistic regression was performed.
  
  
  RESULTS
  Multivariate logistic regressions showed that, compared with unaffected mothers, the adjusted odds ratios of preterm birth and cesarean section for mothers with MVP were 1.27 (95% confidence interval [CI], 1.10-1.48) and 1.34 (95% CI, 1.20-1.50), respectively. In further stratification based on the timing of the MVP diagnosis, the highest risks of preterm birth were observed for mothers diagnosed with MVP during (but not before) pregnancy (odds ratio [OR], 1.54; p = .001). No significant difference was observed between women with and without MVP for other outcomes such as low birthweight, intrapartum complications, low Apgar scores, and congenital malformations.
  
  
  CONCLUSIONS
  Our study found a significant risk of preterm delivery among women with MVP. A multidisciplinary team approach to providing obstetric care, with the mission of monitoring signs of cardiac complications and preterm birth, is imperative.
authors: Department & Institute of Physiology, National Yang-Ming University, Taipei, Taiwan.
authors: Chao-Hung
authors: CH
authors: Chen
authors: Ming-Chao
authors: MC
authors: Huang
authors: Hung-Chang
authors: HC
authors: Liu
authors: Chang-Jer
authors: CJ
authors: Huang
authors: Herng-Ching
authors: HC
authors: Lin
authors: Yu Ru
authors: YR
authors: Kou
mesh_terms: D000293:Adolescent; D000328:Adult; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D008297:Male; D008945:Mitral Valve Prolapse / Q000453:epidemiology; D015999:Multivariate Analysis; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology* / Q000209:etiology; D012042:Registries; D018570:Risk Assessment; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult