title: Cytotoxic and anti-inflammatory cembranoids from the Vietnamese soft coral Lobophytum laevigatum.
abstract: Four new cembranoids, namely laevigatol A-D (1-4), and six known metabolites (5-10), were isolated from the Vietnamese soft coral Lobophytum laevigatum. The structures of these compounds were elucidated by extensive spectroscopic analyses, and the absolute stereochemistry of 1 was determined using the modified Mosher's method. Compounds 5, and 7-10 exhibited cytotoxic activity against selected human cancer cell lines. Compounds 1, 2, 8, and 9 showed dose-dependent inhibitory effects on the TNFα-induced NF-κB transcriptional activity in Hep-G2 cells. Moreover, compounds 1, 2, 8, and 9 significantly inhibited the induction of COX-2 and iNOS mRNA dose-dependently, indicating that these compounds attenuated the synthesis of these transcripts at the transcriptional level.
authors: College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
authors: Tran Hong
authors: TH
authors: Quang
authors: Tran Thu
authors: TT
authors: Ha
authors: Chau Van
authors: CV
authors: Minh
authors: Phan Van
authors: PV
authors: Kiem
authors: Hoang Thanh
authors: HT
authors: Huong
authors: Nguyen Thi Thanh
authors: NT
authors: Ngan
authors: Nguyen Xuan
authors: NX
authors: Nhiem
authors: Nguyen Huu
authors: NH
authors: Tung
authors: Bui Huu
authors: BH
authors: Tai
authors: Dinh Thi Thu
authors: DT
authors: Thuy
authors: Seok Bean
authors: SB
authors: Song
authors: Hee-Kyoung
authors: HK
authors: Kang
authors: Young Ho
authors: YH
authors: Kim
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D014158:Transcription, Genetic / Q000235:genetics / Q000276:immunology; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology; D014744:Vietnam
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D014315:Triterpenes