title: Disassembly of amyloid fibrils by premicellar and micellar aggregates of a tetrameric cationic surfactant in aqueous solution.
abstract: We report a finding that not only the micelles but also the premicellar aggregates of a star-like tetrameric quaternary ammonium surfactant PATC can disassemble and clear mature β-amyloid Aβ(1-40) fibrils in aqueous solution. Different from other surfactants, PATC self-assembles into network-like aggregates below its critical micelle concentration (CMC). The strong self-assembly ability of PATC even below its CMC enables PATC to disaggregate the Aβ(1-40) fibrils far below the charge neutralization point of the Aβ(1-40) with PATC. There may be two key features of the fibril disassembly induced by the surfactant. First, the positively charged surfactant molecules bind with the negatively charged Aβ(1-40) fibrils through electrostatic interaction. Second, the self-assembly of the surfactant molecules bound onto the Aβ(1-40) fibrils disaggregate the fibrils, and the surfactant molecules form mixed aggregates with the Aβ(1-40) molecules. The result reveals a structural approach of constructing efficient disassembly agents to mature β-amyloid fibrils.
authors: Key Laboratory of Colloid and Interface Science, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors: Chengqian
authors: C
authors: He
authors: Yanbo
authors: Y
authors: Hou
authors: Yuchun
authors: Y
authors: Han
authors: Yilin
authors: Y
authors: Wang
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D002412:Cations; D019281:Dimerization; D006801:Humans; D008823:Micelles; D000644:Quaternary Ammonium Compounds; D012996:Solutions; D055672:Static Electricity; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water
chemical_list: D000682:Amyloid; D002412:Cations; D008823:Micelles; D000644:Quaternary Ammonium Compounds; D012996:Solutions; D013501:Surface-Active Agents; D014867:Water