title: Increased S-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with cough variant asthma.
abstract: BACKGROUND
  Nonasthmatic eosinophilic bronchitis (NAEB) and cough variant asthma (CVA) are common causes of chronic cough. Both are characterized by eosinophilic inflammation in the airways. However, airway hyperresponsiveness, which is a characteristic feature of CVA, is not observed in NAEB. We hypothesized that endogenous bronchodilator S-nitrosothiol (SNO) levels are different between patients with NAEB and CVA.
  
  
  METHODS
  SNO concentrations in sputum supernatant were measured using a commercially available kit in 20 NAEB and 21 CVA patients.
  
  
  RESULTS
  The mean sputum eosinophil counts and exhaled nitric oxide values were similar in patients with NAEB (12.4 ± 2.3%, 80.6 ± 8.1 ppb) and CVA (15.3 ± 3.7%, 97.7 ± 9.2 ppb). By contrast, SNO levels in the airway lining fluid of NAEB patients were substantially higher than those of CVA patients (87.1 ± 9.8 vs. 46.8 ± 4.8 μM; p < 0.05).
  
  
  CONCLUSIONS
  SNOs may be an important factor in determining the development of airway hyperresponsiveness in the presence of eosinophilic inflammation.
authors: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Byung-Jae
authors: BJ
authors: Lee
authors: Yun-Jin
authors: YJ
authors: Jeung
authors: Jin-Young
authors: JY
authors: Lee
authors: Dong-Chull
authors: DC
authors: Choi
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D029481:Bronchitis, Chronic / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000737:chemistry / Q000627:therapeutic use; D003371:Cough / Q000209:etiology*; D004802:Eosinophilia / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D045853:Exhalation; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis; D026403:S-Nitrosothiols / Q000032:analysis* / Q000627:therapeutic use; D013183:Sputum / Q000737:chemistry* / Q000166:cytology / Q000276:immunology; D055815:Young Adult
chemical_list: D001993:Bronchodilator Agents; D026403:S-Nitrosothiols; D009569:Nitric Oxide