title: Sc(III)-catalyzed enantioselective addition of thiols to α,β-unsaturated ketones in neutral water.
abstract: This report concerns Lewis acid catalyzed enantioselective sulfa-Michael addition in neutral water by using a very efficient Sc(OTf)(3)/bipyridine 1 catalytic system. It is noteworthy that the protocol presented employs water as a reaction medium and allows us to obtain very high stereoselectivity and satisfactory yields for β-keto sulphides deriving from aliphatic thiols. The recovery and reuse of both the aqueous medium and the catalytic system is also reported.
authors: Laboratory of Green Synthetic Organic Chemistry, CEMIN-Dipartimento di Chimica, Università di Perugia Via Elce di Sotto, 8, Perugia, Italy.
authors: Simona
authors: S
authors: Bonollo
authors: Daniela
authors: D
authors: Lanari
authors: Ferdinando
authors: F
authors: Pizzo
authors: Luigi
authors: L
authors: Vaccaro