title: The molecular biology of human herpesvirus-6 latency and telomere integration.
abstract: The genomes of herpesviruses establish latency as a circular episome. However, Human herpesvirus-6 (HHV-6) has been shown to specifically integrate into the telomeres of chromosomes during latency and vertically transmit through the germ-line. This review will focus on the telomere integration of HHV-6, the potential viral and cellular genes that mediate integration, and the clinical impact on the host.
authors: Department of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA.
authors: Jesse H
authors: JH
authors: Arbuckle
authors: Peter G
authors: PG
authors: Medveczky
mesh_terms: D015654:Herpesvirus 6, Human / Q000235:genetics / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D019349:Roseolovirus Infections / Q000821:virology*; D016615:Telomere / Q000502:physiology*; D016662:Virus Integration; D017735:Virus Latency