title: Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth.
abstract: LRRC4 is not only a brain-specific gene, but it has also been identified as a tumor suppressor gene for glioma. Promoter methylation of LRRC4 is frequently involved in the inactivation in glioma. MiRNA-mediated gene regulation has recently been demonstrated to play an important role in multiple biological processes related to cancer, including glioma. In this study, we demonstrated that a small regulatory microRNA, hsa-miR-381, an "oncomir", had a major role in glioma progression and that LRRC4 was a target of hsa-miR-381. By regulating LRRC4, hsa-miR-381 increased the in vitro and in vivo proliferation of glioma cells, and this action was associated with decreased inhibition of MEK/ERK and AKT signaling. Conversely, LRRC4, as a glioma suppressor, inhibited the endogenous expression of hsa-miR-381 and decreased cell proliferation and tumor growth. The interaction of hsa-miR-381 and LRRC4 is involved in the pathogenesis of glioma. In addition, the stable expression of hsa-miR-381 in blood provides a novel and promising diagnostic biomarker, and anti-hsa-miR-381 "antagomir" may be an ideal target for glioma therapy.
authors: Cancer Research Institute, Central South University, 110(#) Xiang-Ya Road, Changsha 410078, Hunan, PR China.
authors: Hailin
authors: H
authors: Tang
authors: Xiaoping
authors: X
authors: Liu
authors: Zeyou
authors: Z
authors: Wang
authors: Xiaoling
authors: X
authors: She
authors: Xi
authors: X
authors: Zeng
authors: Min
authors: M
authors: Deng
authors: Qianjin
authors: Q
authors: Liao
authors: Xiaofang
authors: X
authors: Guo
authors: Rong
authors: R
authors: Wang
authors: Xiaoling
authors: X
authors: Li
authors: Fang
authors: F
authors: Zeng
authors: Minghua
authors: M
authors: Wu
authors: Guiyuan
authors: G
authors: Li
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000235:genetics; D018450:Disease Progression; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D019073:HT29 Cells; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D011897:Random Allocation
chemical_list: C503331:LRRC4 protein, human; D035683:MicroRNAs; D009419:Nerve Tissue Proteins