title: Release of adriamycin from poly(lactide-co-glycolide)-polyethylene glycol nanoparticles.
abstract: In order to develop a prolonged circulating drug carrier and to overcome p-glycoprotein-mediated multidrug resistance to adriamycin (ADR), which is a potent chemotherapeutic agent in the treatment of various cancers, poly(lactide-co-glycolide)-polyethylene glycol (PLGA-PEG) nanoparticles were prepared and characterized. ADR-loaded PLGA-PEG nanoparticles prepared by the emulsification-diffusion method were spherical and homogeneous with smooth surfaces when assessed by scanning electron microscopy. The nanoparticles were 200-230 nm in size and the encapsulation efficiency of ADR in the nanoparticles was 30 approximately 35%. The release of ADR from nanoparticles was extended compared to that from free ADR solution. After intravenous administration of adriamycin-loaded PLGA-PEG nanoparticles to rats, the plasma level of ADR from PLGA-PEG nanoparticle was extended until 24 hours and the mean residence time of ADR of nanoparticles was increased compared to that of ADR solution. And ADR-loaded nanoparticles showed a higher growth inhibitory effect than free ADR solution in an ADR resistant MCF-7 human breast carcinoma cell line. The prepared ADR-loaded PLGA-PEG nanoparticles can be used as a good delivery system for ADR.
authors: College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Republic of Korea.
authors: Sei-Myoung
authors: SM
authors: Mo
authors: In-Joon
authors: IJ
authors: Oh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000097:blood; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011098:Polyglactin 910 / Q000737:chemistry; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; C102418:poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer; D011098:Polyglactin 910; D011092:Polyethylene Glycols; D004317:Doxorubicin