title: The relationship between the val158met catechol-O-methyltransferase (COMT) polymorphism and irritable bowel syndrome.
abstract: BACKGROUND
  The catechol-O-methyltransferase (COMT) enzyme has a key function in the degradation of catecholamines and a functional polymorphism is val158met. The val/val genotype results in a three to fourfold higher enzymatic activity compared with the met/met genotype, with the val/met genotype exhibiting intermediate activity. Since pain syndromes as well as anxiety and depression are associated to low and high COMT activity respectively and these conditions are all associated with irritable bowel syndrome (IBS) we wanted for the first time to explore the relationship between the polymorphism and IBS.
  
  
  RESULTS
  867 subjects (445 women) representative of the general population and 70 consecutively sampled patients with IBS (61 women) were genotyped for the val158met polymorphism and the IBS patients filled out the Hospital-Anxiety-and-Depression-Scale (HADS) questionnaire, and an IBS symptom diary.
  
  
  RESULTS
  There was a significantly higher occurrence of the val/val genotype in patients compared with controls (30% vs 20%; Chi(2) (1) 3.98; p = 0.046) and a trend toward a lower occurrence of the val/met genotype in IBS patients compared with controls (39% vs 49%; Chi(2) (1) 2.89; p = 0.089). Within the IBS patients the val/val carriers exhibited significantly increased bowel frequency (2.6 vs 1.8 stools per day; Chi(2) (1) 5.3; p = 0.03) and a smaller proportion of stools with incomplete defecation (41% vs 68%; Chi(2) (1) 4.3; p = 0.04) compared with the rest (val/met+met/met carriers). The val/val carriers also showed a trend for a smaller proportion of hard stools (0% vs 15%; Chi(2) (1) 3.2; p = 0.08) and a higher frequency of postprandial defecation (26% vs 21%; Chi(2) (1) 3.0; p = 0.08).
  
  
  CONCLUSIONS
  In this study we found an association between the val/val genotype of the val158met COMT gene and IBS as well as to specific IBS related bowel pattern in IBS patients.
authors: Division of Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. pontus.karling@vll.se
authors: Pontus
authors: P
authors: Karling
authors: Åke
authors: Å
authors: Danielsson
authors: Mikael
authors: M
authors: Wikgren
authors: Ingegerd
authors: I
authors: Söderström
authors: Jurgen
authors: J
authors: Del-Favero
authors: Rolf
authors: R
authors: Adolfsson
authors: Karl-Fredrik
authors: KF
authors: Norrback
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics*; D001007:Anxiety / Q000150:complications; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002908:Chronic Disease; D003863:Depression / Q000150:complications; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D015233:Models, Statistical; D010146:Pain / Q000150:complications; D010342:Patient Acceptance of Health Care; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D002394:Catechol O-Methyltransferase