title: Vascular time-activity variation in patients undergoing ¹²³I-MIBG myocardial scintigraphy: implications for quantification of cardiac and mediastinal uptake.
abstract: OBJECTIVE
  For the quantification of cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake, the mediastinum is commonly used as a reference region reflecting nonspecific background activity. However, variations in the quantity of vascular structures in the mediastinum and the rate of renal clearance of (123)I-MIBG from the blood pool may contribute to increased interindividual variation in uptake. This study examined the relationship between changes in heart (H) and mediastinal (M) counts and the change in vascular (123)I-MIBG activity, including the effect of renal function.
  
  
  METHODS
  Fifty-one subjects with ischemic heart disease underwent early (15 min) and late (4 h) anterior planar images of the chest following injection of (123)I-MIBG. Vascular (123)I-MIBG activity was determined from venous blood samples obtained at 2 min, 15 min, 35 min, and 4 h post-injection. From the vascular clearance curve of each subject, the mean blood counts/min per ml at the time of each acquisition and the slope of the clearance curve were determined. Renal function was expressed as the estimated creatinine clearance (e-CC) and the estimated glomerular filtration rate (e-GFR). Relations between H and M region of interest (ROI) counts/pixel, vascular activity, and renal function were then examined using linear regression.
  
  
  RESULTS
  Changes in ROI activity ratios between early and late planar images could not be explained by blood activity, the slope of the vascular clearance curves, or estimates of renal function. At most 3% of the variation in image counts could be explained by changes in vascular activity (p = 0.104). The e-CC and e-GFR could at best explain approximately 1.5% of the variation in the slopes of the vascular clearance curve (p = 0.194).
  
  
  CONCLUSIONS
  The change in measured H and M counts between early and late planar (123)I-MIBG images is unrelated to intravascular levels of the radiopharmaceutical. This suggests that changes in M counts are primarily due to decrease in soft tissue activity and scatter from the adjacent lungs.
authors: Department of Nuclear Medicine, room F2-238, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE, Amsterdam, The Netherlands. h.j.verberne@amc.uva.nl
authors: Hein J
authors: HJ
authors: Verberne
authors: Derk O
authors: DO
authors: Verschure
authors: G Aernout
authors: GA
authors: Somsen
authors: Berthe L F
authors: BL
authors: van Eck-Smit
authors: Arnold F
authors: AF
authors: Jacobson
mesh_terms: D019797:3-Iodobenzylguanidine / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D001808:Blood Vessels / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000378:metabolism; D055414:Myocardial Perfusion Imaging; D009206:Myocardium / Q000378:metabolism*; D011875:Radionuclide Angiography; D013997:Time Factors
chemical_list: D019797:3-Iodobenzylguanidine