title: Signaling at the Golgi.
abstract: The protein processing and trafficking function of the Golgi is intimately linked to multiple intracellular signaling pathways. Assembly of Golgi trafficking structures and lipid sorting at the Golgi complex is controlled and coordinated by specific phosphoinositide kinases and phosphatases. The intra-Golgi transport machinery is also regulated by kinases belonging to several functionally distinct families, for example, MAP kinase signaling is required for mitotic disassembly of the Golgi. However, the Golgi plays an additional, prominent role in compartmentalizing other signaling cascades that originate at the plasma membrane or at other organelles. This article summarizes recent advances in our understanding of the signaling network that converges at the Golgi.
authors: Division of Nephrology and Hypertension and Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR 97239, USA. mayinger@ohsu.edu
authors: Peter
authors: P
authors: Mayinger
mesh_terms: D001692:Biological Transport; D049108:Cell Enlargement; D002462:Cell Membrane / Q000378:metabolism; D049109:Cell Proliferation; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism / Q000502:physiology; D006056:Golgi Apparatus / Q000378:metabolism*; D050356:Lipid Metabolism; D010716:Phosphatidylinositols / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction
chemical_list: D010716:Phosphatidylinositols; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases