title: [Study on acute toxicity and animal gastrointestinal activity of crude and processed products of Entada phaseoloides].
abstract: OBJECTIVE
  To study the acute toxicity of the crude and processed products of Entada phaseoloides and their effects on gastrointestinal movement in mice.
  
  
  METHODS
  Using the method of intragastric administration, to observe the acute toxicity of the crude and processed products of Entada phaseoloides in mice and determine their LD50. With the methods of charcoal propulsion of small intestine and methyl orange colorimetry of gastric emptying, to study the impact of the crude and processed products of Entada on gastrointestinal movement in mice.
  
  
  RESULTS
  The oral LD50 of crude Entada phaseoloides, No. 1 and No. 2 processed products of Entada phaseoloides in mice were 27.17, 35.13, 42.18 g/kg body weight. Crude and processed products of Entada phaseoloides can significantly promote the enteric propulsion of normal mice, and can significantly counteract the depressing status induced by atropine, but have no influence on the overactive status induced by neostigmine. The high, middle and low-dose of groups showed significant inhibition of the gastric emptying in normal mice.
  
  
  CONCLUSIONS
  Processed Entada phaseoloides showed effects on the enteric propulsion of normal and depressing mice, can restrain the gastric emptying under normal mice, but its safety is better than crude Entada phaseoloides.
authors: College of Pharmacy, South-central University for Nationalities, Wuhan 430074, China. aother258@yahoo.com.cn
authors: Er
authors: E
authors: Xiao
authors: Hui
authors: H
authors: Xiong
authors: Ying-Hong
authors: YH
authors: Zhao
authors: Xu-Kun
authors: XK
authors: Deng
authors: Zhi-Nan
authors: ZN
authors: Mei
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D001285:Atropine / Q000008:administration & dosage; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D007887:Fabaceae / Q000737:chemistry* / Q000633:toxicity; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000473:pathology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009388:Neostigmine / Q000008:administration & dosage; D011897:Random Allocation; D012639:Seeds / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D009388:Neostigmine; D001285:Atropine