title: Is the lower cyclosporine concentration at 2 hours after dosing safe in kidney transplant recipients?
abstract: OBJECTIVE
  To determine the correlation between cyclosporine blood concentration at 2 hours after dosing (C2) and renal allograft function.
  
  
  METHODS
  From 2008 to 2010, 1191 kidney transplant recipients (718 male and 473 female patients) were studied. The correlation between serum creatinine concentration and C2 blood concentration was stratified as 400, 600, 800, and 1000 ng/mL.
  
  
  RESULTS
  The mean (SD) C2 was 620 (235) ng/mL, and serum creatinine concentration was 1.49 (0.68) mg/dL. At multivariate regression analysis, no significant correlation was observed between serum creatinine concentration and C2 blood concentrations of 600, 800, or 1000 ng/mL (P=.18, .57, and .76, respectively); however, it was associated at 400 ng/mL (P=.03). Moreover, 36.1% of 3159 samples demonstrated satisfactory renal allograft function despite low C2 blood concentration between 400 and 600 ng/mL.
  
  
  CONCLUSIONS
  During maintenance therapy, C2 blood concentration between 400 and 600 ng/mL is effective and safe for providing prophylaxis against rejection, and can improve long-term survival by decreasing cyclosporine toxicity.
authors: Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, and Baqiyatallah Hospital, Tehran, Iran. einollahi@ijnu.ir
authors: B
authors: B
authors: Einollahi
authors: Z
authors: Z
authors: Rostami
authors: E
authors: E
authors: Kalantar
authors: M
authors: M
authors: Lessan-Pezeshki
authors: V
authors: V
authors: Pourfarziani
authors: E
authors: E
authors: Nemati
mesh_terms: D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000097:blood* / Q000493:pharmacokinetics; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood* / Q000493:pharmacokinetics; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D015999:Multivariate Analysis; D012044:Regression Analysis; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine