title: Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria.
abstract: Trans-resveratrol is a nutraceutical with known antioxidant, anti-inflammatory, cardioprotective, and anti-apoptotic properties. The aim of this study was to evaluate the effects of resveratrol on heart mitochondria. Resveratrol significantly decreased Fe(2+) + ascorbate oxidant system-induced lipid peroxide levels, preserved physiological levels of glutathione, and increased nitric oxide (NO) levels in mitochondria. Under calcium-mediated stress, there was a 2.7-fold increase in the NO levels, and a mild decoupling in the mitochondrial respiratory chain. These results provide a mechanism for and support the beneficial effects of resveratrol under pathological conditions induced by oxidative stress and calcium overload. In addition, these findings underscore the usefulness of resveratrol in the prevention of cardiovascular diseases.
authors: Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich., México. saavedra@umich.mx
authors: Areli
authors: A
authors: Gutiérrez-Pérez
authors: Christian
authors: C
authors: Cortés-Rojo
authors: Ruth
authors: R
authors: Noriega-Cisneros
authors: Elizabeth
authors: E
authors: Calderón-Cortés
authors: Salvador
authors: S
authors: Manzo-Avalos
authors: Mónica
authors: M
authors: Clemente-Guerrero
authors: Daniel
authors: D
authors: Godínez-Hernández
authors: Istvan
authors: I
authors: Boldogh
authors: Alfredo
authors: A
authors: Saavedra-Molina
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D002118:Calcium / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D005978:Glutathione / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D009569:Nitric Oxide; D007501:Iron; D005978:Glutathione; D001205:Ascorbic Acid; D000077185:Resveratrol; D002118:Calcium