title: Chemical structures of odorants that suppress ion channels in the olfactory receptor cell.
abstract: It has been proposed that odorant suppression of the cyclic nucleotide-gated (CNG) channel is responsible for olfactory masking. In this study, the effect of odorant chain length and functional group on this suppression was investigated. Because similar suppression has been observed for voltage-gated channels also, we used voltage-gated Na channels in the olfactory receptor cell as a tool for substance screening. These features were then re-examined using CNG channels. Interestingly, both CNG and Na channels were suppressed in a similar manner-carboxylic acids had little effect and suppression became stronger when the chain length of the alcohol or ester was increased. Degree of suppression was correlated with the distribution coefficients (Log D), irrespective of the molecules used. Results obtained here may provide information for the development of novel masking agents based on molecular architecture.
authors: Graduate School of Frontier Bioscience, Osaka University, Osaka, 560-8531, Japan.
authors: Yukako
authors: Y
authors: Kishino
authors: Hiroyuki
authors: H
authors: Kato
authors: Takashi
authors: T
authors: Kurahashi
authors: Hiroko
authors: H
authors: Takeuchi
mesh_terms: D000818:Animals; D002264:Carboxylic Acids / Q000378:metabolism; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000378:metabolism*; D015640:Ion Channel Gating / Q000502:physiology*; D009812:Odorants; D018034:Olfactory Receptor Neurons / Q000378:metabolism*; D012455:Salamandridae; D015398:Signal Transduction; D012903:Smell / Q000187:drug effects / Q000502:physiology*; D015222:Sodium Channels / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D002264:Carboxylic Acids; D054815:Cyclic Nucleotide-Gated Cation Channels; D015222:Sodium Channels