title: Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer.
abstract: OBJECTIVE
  To evaluate the association between of the interleukin-10 (IL-10) promoter polymorphisms and survival of advanced gastric cancer (GC) patients.
  
  
  METHODS
  The IL-10 (-1082, rs1800896; -819, rs1800871; and-592, rs1800896) genotypes in 234 patients with advanced gastric cancer and in 243 healthy controls were determined by polymerase chain reaction-restriction fragment length polymorphism assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional logistic regression for the associations between IL-10 genotypes and the risk of GC. The Kaplan-Meier method with log-rank testing was used to evaluate the association between genotype and survival of the patients.
  
  
  RESULTS
  The IL-10 -1082 G allele and GCC (-1082, -819 and -592) haplotype were associated with increased gastric cancer risks (OR 1.2, 95% CI 0.6-3.2, P = 0.007, for -1082 G allele, OR = 2.3, 95% CI, 1.2-4.1, P = 0.005, for GCC haplotype, respectively). However, none of the three IL-10 gene polymorphisms (-1082, -819 and -592) was correlated with gastric cancer survival (P > 0.05), and none of the genotypes of the three IL-10 sites was found as independent prognostic risk factors in the multivariate test.
  
  
  CONCLUSIONS
  IL-10 gene promoter polymorphisms may not be associated with the prognosis of advanced gastric cancer.
authors: Department of Chemotherapy Oncology, Shandong Academy of Medical Sciences, Shandong Province, China.
authors: Jie
authors: J
authors: Liu
authors: Bao
authors: B
authors: Song
authors: Jia-Lin
authors: JL
authors: Wang
authors: Zeng-Jun
authors: ZJ
authors: Li
authors: Wan-Hu
authors: WH
authors: Li
authors: Zhe-Hai
authors: ZH
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D011379:Prognosis; D011401:Promoter Regions, Genetic; D012044:Regression Analysis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D016753:Interleukin-10