title: Influence of photon energy on the quality of prostate intensity modulated radiation therapy plans based on analysis of physical indices.
abstract: The goal of the present study was to study the effects of low- and high-energy intensity-modulated photon beams on the planning of target volume and the critical organs in cases of localized prostate tumors in a cohort of 8 patients. To ensure that the difference between the plans is due to energy alone, all other parameters were kept constant. A mean dose volume histogram (DVH) for each value of energy and for each contoured structure was created and was considered as completely representative for all patients. To facilitate comparison between 6-MV and 15-MV beams, the DVH-s were normalized. The different parameters that were compared for 6-MV and 15-MV beams included mean DVH, different homogeneity indices, conformity index, etc. Analysis of several indices depicts more homogeneous dose for 15-MV beam and more conformity for 6-MV beam. Comparison of all these parameters showed that there was little difference between the 6-MV and 15-MV beams. For rectum, 2 to 4 % more volume received high dose with the 6-MV beam in comparison with the 15-MV beam, which was not clinically significant, since in practice much tighter constraints are maintained, such that Normal Tissue Complication Probability (NTCP) is kept within 5 %. Such tighter constraints might increase the dose to other regions and other critical organs but are unlikely to increase their complication probabilities. Hence the slight advantages of 15-MV beam in providing benefits of better normal-tissue sparing and better coverage cannot be considered to outweigh its well-known risk of non-negligible neutron production.
authors: Department of Radiation Oncology, G. Kuppuswamy Naidu Memorial Hospital, India.
authors: Sundaram
authors: S
authors: Thangavelu
authors: S
authors: S
authors: Jayakumar
authors: K N
authors: KN
authors: Govindarajan
authors: Sanjay S
authors: SS
authors: Supe
authors: V
authors: V
authors: Nagarajan
authors: M
authors: M
authors: Nagarajan