title: Dietary β-glucan regulates the levels of inflammatory factors, inflammatory cytokines, and immunoglobulins in interleukin-10 knockout mice.
abstract: β-Glucan is known to have anti-inflammatory properties, and several studies have demonstrated the beneficial effects of dietary β-glucan on inflammatory bowel disease (IBD). However, it is unknown how β-glucan mediates its protective effects on IBD. Therefore, we used a well-established mouse model for IBD, interleukin (IL)-10(-/-) mice, to explore the protective effects of β-glucan on IBD-like symptoms caused by IL-10 deficiency. The mice were divided into two groups: IL-10(-/-) and IL-10(-/-) + β-glucan treatment groups. IL-10(-/-) mice treated with dietary β-glucan exhibited less inflammation within the colon. The levels of immunoglobulins A and E were lower in the serum, spleen, mesenteric lymph nodes, and Peyer's patches in the IL-10(-/-) mice compared with the IL-10(-/-) + β-glucan mice. Also, the expression of pro-inflammatory cytokines was lower in the IL-10(-/-) + β-glucan mice compared with the IL-10(-/-) mice. Histological analysis also revealed that administration of dietary β-glucan in IL-10(-/-) mice reduced colonic tissue damage. Finally, the expression of the pro-inflammatory cytokine tissue necrosis factor-α was significantly lower with dietary β-glucan treatment in IL-10(-/-) mice. In conclusion, dietary β-glucan reduces the inflammation associated with IBD caused by IL-10 deficiency.
authors: Department of Life Sciences, College of Biomedical & Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea.
authors: Michael B
authors: MB
authors: Ye
authors: Jong Phil
authors: JP
authors: Bak
authors: Chi Sun
authors: CS
authors: An
authors: Hai Lan
authors: HL
authors: Jin
authors: Jong Moon
authors: JM
authors: Kim
authors: Hyuk Jung
authors: HJ
authors: Kweon
authors: Dong Kug
authors: DK
authors: Choi
authors: Pyo Jam
authors: PJ
authors: Park
authors: Young Jun
authors: YJ
authors: Kim
authors: Beong Ou
authors: BO
authors: Lim
mesh_terms: D000818:Animals; D015153:Blotting, Western; D003106:Colon / Q000473:pathology; D004032:Diet; D004195:Disease Models, Animal; D007070:Immunoglobulin A / Q000097:blood* / Q000378:metabolism; D007073:Immunoglobulin E / Q000097:blood* / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000473:pathology; D016753:Interleukin-10 / Q000032:analysis / Q000172:deficiency*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010581:Peyer's Patches / Q000166:cytology / Q000378:metabolism; D047071:beta-Glucans / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D007070:Immunoglobulin A; D047071:beta-Glucans; D016753:Interleukin-10; D007073:Immunoglobulin E