title: Association between acute pancreatitis and peptic ulcer disease.
abstract: OBJECTIVE
  To evaluate the relationship between peptic ulcer disease (PUD) and acute pancreatitis.
  
  
  METHODS
  A cohort of 78 patients with acute pancreatitis were included in this study. The presence of PUD and the Helicobacter pylori (H. pylori) status were assessed by an endoscopic method. The severity of acute pancreatitis was assessed using Ranson's score, the Acute Physiology and Chronic Health Evaluation (APACHE) II score, computed tomography severity index and the clinical data during hospitalization, all of which were compared between the patients with and without PUD. The risk factors for PUD were also evaluated.
  
  
  RESULTS
  Among 78 patients, 41 patients (52.6%) with acute pancreatitis suffered from PUD, but only 13 (31.7%) patients with PUD were infected by H. pylori. On univariate analysis, male gender, an etiology of alcohol-induced pancreatitis, a history of smoking or alcohol consumption, elevated triglyceride and C-reactive protein levels, and high APACHE II score were significantly associated with PUD. However, on multivariate logistic regression analysis, the APACHE II score (odds ratio: 7.69; 95% confidence interval: 1.78-33.33; P < 0.01) was found to be the only independent risk factor for PUD.
  
  
  CONCLUSIONS
  Patients with acute pancreatitis are liable to suffer from PUD. PUD is associated with severe acute pancreatitis according to the APACHE II score, and treatment for PUD should be considered for patients with severe acute pancreatitis.
authors: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Gyeonggi-do, South Korea.
authors: Kang-Moon
authors: KM
authors: Lee
authors: Chang-Nyol
authors: CN
authors: Paik
authors: Woo Chul
authors: WC
authors: Chung
authors: Jin Mo
authors: JM
authors: Yang
mesh_terms: D018806:APACHE; D000368:Aged; D005260:Female; D016481:Helicobacter Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications*; D010437:Peptic Ulcer / Q000209:etiology* / Q000382:microbiology; D012307:Risk Factors