title: Novel M-component based biomarkers in Waldenström's macroglobulinemia.
abstract: Waldenstrom's macroglobulinemia (WM) is an indolent B-cell lymphoma of the lymphoplasmacytic type accompanied by a serum IgM component. However, conventional IgM quantification lacks sensitivity, does not precisely reflect tumor burden of WM, and, although being the main marker for monitoring response to treatment, may not be accurate. New serum M-component based biomarkers were developed for routine practice in recent years, such as the Freelite® test and more recently the Hevylite test®. Studies have shown that Freelite was a prognostic marker for time to treatment in WM that helps monitoring disease response or progression. Hevylite measures IgMkappa and IgMlambda, separately, and might provide true quantitative measurement of the IgM M-spike. Although current data are preliminary, Hevylite® might replace the current technique to measure IgM M-spike in the years to come. We summarize herein studies conducted to delineate the role of these tests in WM.
authors: Service des Maladies du Sang, Hôpital Huriez, CHRU, Lille, France.
authors: Xavier
authors: X
authors: Leleu
authors: Efstathios
authors: E
authors: Koulieris
authors: Dimitrios
authors: D
authors: Maltezas
authors: Raphael
authors: R
authors: Itzykson
authors: Wanling
authors: W
authors: Xie
authors: Salomon
authors: S
authors: Manier
authors: Remy
authors: R
authors: Dulery
authors: Eilleen
authors: E
authors: Boyle
authors: Jordan
authors: J
authors: Gauthier
authors: Stéphanie
authors: S
authors: Poulain
authors: Tzenou
authors: T
authors: Tatiana
authors: Panayiotis
authors: P
authors: Panayiotidis
authors: Arthur R
authors: AR
authors: Bradwell
authors: Stephen
authors: S
authors: Harding
authors: Veronique
authors: V
authors: Leblond
authors: Marie-Christine
authors: MC
authors: Kyrtsonis
authors: Irene M
authors: IM
authors: Ghobrial
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009194:Myeloma Proteins / Q000378:metabolism*; D008258:Waldenstrom Macroglobulinemia / Q000097:blood* / Q000473:pathology
chemical_list: D015415:Biomarkers; D009194:Myeloma Proteins