title: Progressive multiple sclerosis: characteristics and management.
abstract: Progressive multiple sclerosis (MS) consists of 3 phenotypic subtypes: secondary progressive MS, primary progressive MS, and progressive relapsing MS. There has been a paucity of approved treatments for these subtypes possibly driven by irreversible neurodegeneration within the central nervous system and not amenable to drugs that target inflammation. This article reviews magnetic resonance imaging and clinical data that show that progression may occur early in the course of MS and specific subsets of progressive patients may respond to disease modifying drugs.
authors: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. hawkerks@lilly.com
authors: Kathleen
authors: K
authors: Hawker
mesh_terms: D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*