title: Clinical utility of serum interleukin-8 and interferon-alpha in thyroid diseases.
abstract: Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre (N = 21), autoimmune diseases (N = 16), and carcinomas (N = 32). Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals. Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients. Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters. IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients. Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies.
authors: Division of Molecular Endocrinology, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India.
authors: Toral P
authors: TP
authors: Kobawala
authors: Girish H
authors: GH
authors: Patel
authors: Dhara R
authors: DR
authors: Gajjar
authors: Kamini N
authors: KN
authors: Patel
authors: Premal B
authors: PB
authors: Thakor
authors: Urvi B
authors: UB
authors: Parekh
authors: Kirti M
authors: KM
authors: Patel
authors: Shilin N
authors: SN
authors: Shukla
authors: Pankaj M
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