title: Treatment of Nigella sativa in experimental sepsis model in rats.
abstract: This experimental study was designed to determine effects of Nigella sativa oil (NSO) on endothelin-1 (ET-1) level and oxidative stress parameters, superoxide dismutase (SOD) and malondialdehyde (MDA) in a rat sepsis model. Twenty four adult Wistar albino rats were divided randomly into three groups: sham group (group 1), sepsis group (group 2), sepsis group pretreated with NSO (group 3). Serum ET-1, tissue SOD and tissue MDA levels were measured in all groups. Compared to group 1, ET-1 and MDA levels were higher in group 2. ET-1 and MDA levels in NSO pretreated group 3 were lower with respect to group 2 (p<0.03, and p<0.02, respectively). Additionally, SOD levels in group 3 were found to be higher than group 2 (p<0.02). Based on our results, it can be concluded that NSO may have a positive impact on ET-1 levels and oxidative stress induced by sepsis in experimental rat models.
authors: Department of Infectious Diseases and Clinical Bacteriology, Medical Park Hospital, Istanbul,Turkey.
authors: Ozlem
authors: O
authors: Alici
authors: Havva Sahin
authors: HS
authors: Kavakli
authors: Cemile
authors: C
authors: Koca
authors: Neriman Defne
authors: ND
authors: Altintas
mesh_terms: D000818:Animals; D019332:Endothelin-1 / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D018384:Oxidative Stress; D008517:Phytotherapy; D010938:Plant Oils / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000188:drug therapy* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D029974:Carum
chemical_list: D019332:Endothelin-1; D010938:Plant Oils; D008315:Malondialdehyde; C104525:caraway oil; D013482:Superoxide Dismutase