title: Mycophenolate mofetil may be effective in CNS sarcoidosis but not in sarcoid myopathy.
abstract: OBJECTIVE
  To describe effectiveness, steroid-sparing effect, and tolerance of the antiproliferative immunosuppressant mycophenolate mofetil (MMF) in neurosarcoidosis.
  
  
  METHODS
  We describe a retrospective case series of 10 consecutive patients with a diagnosis of neurosarcoidosis who were treated with MMF, alone or in association with corticosteroids, in our teaching hospital.
  
  
  RESULTS
  At the time of our study, the mean duration of MMF treatment was 21 months. All but one patient with CNS involvement (n = 8) were in remission (except for hormonal dysfunction) which was complete in 6 patients. MMF was efficient as single-agent induction therapy in one patient. The 3 patients who received MMF as a maintenance therapy after initial response to corticosteroids did not relapse even though steroids were stopped. Out of 4 subjects who demonstrated insufficient response to prior therapy including corticosteroids and immunosuppressive agents, 3 demonstrated significant clinical and radiologic improvement. However, the 2 patients who presented muscular sarcoidosis did not respond to MMF. Among patients treated with steroids at MMF introduction and after excluding those with sarcoid myopathy, the mean dose of corticosteroids was 6 mg/day at the end of the follow-up while it was 59 mg/day at the initiation of MMF. No significant side effects were observed.
  
  
  CONCLUSIONS
  These data suggest that MMF is effective in CNS sarcoidosis but not in sarcoid myopathy, with a corticosteroid sparing effect and a better tolerance profile than other immunosuppressive agents.
authors: Department of Neurology A, Hôpital Neurologique, Hospices Civils de Lyon, France.
authors: G
authors: G
authors: Androdias
authors: D
authors: D
authors: Maillet
authors: R
authors: R
authors: Marignier
authors: L
authors: L
authors: Pinède
authors: C
authors: C
authors: Confavreux
authors: C
authors: C
authors: Broussolle
authors: S
authors: S
authors: Vukusic
authors: P
authors: P
authors: Sève
mesh_terms: D000328:Adult; D000368:Aged; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D009135:Muscular Diseases / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid