title: [Application of quantitative fingerprint technique for in-process quality control of Guizhi Fuling capsules].
abstract: OBJECTIVE
  To investigate an evaluation mode FOR in-process quality control for traditional Chinese medicines by adopting quantitative fingerprint technique as the main mean.
  
  
  METHODS
  Regarding Guizhi Fuling capsules as an example, the stability and repeatability were observed by tests of quantitative fingerprint of 90% ethanol extract, aqueous extract, the final mixing extract, soft material and products during the production process.
  
  
  RESULTS
  The fingerprint similarities of four kinds of intermediates and products from 10 batches of Guizhi Fuling capsules were in the range of 0.966-0.999, respectively. The RSD of quantitative results of marked components, which included gallic acid, paeoniflorin, benzoic acid, cinnamic acid, benzoyl paeoniflorin, cinnamic aldehyde, paeonol, etc, were less than 15% in the products.
  
  
  CONCLUSIONS
  This method is accurate, feasible and could be an effective way to be applied to in-process quality control of traditional Chinese medicine.
authors: Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China. ljclyg2010@163.com
authors: Jiachun
authors: J
authors: Li
authors: Na
authors: N
authors: Liang
authors: Wei
authors: W
authors: Xiao
authors: Yu'an
authors: Y
authors: Bi
authors: Zhenzhong
authors: Z
authors: Wang
mesh_terms: D002214:Capsules; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000592:standards*; D011786:Quality Control
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; C525079:guizhi-fuling