title: Genotypic prediction of resistant mutation in HIV-1 pol gene towards the antiretroviral drugs.
abstract: Mutation in HIV-1 pol gene confers the resistance to antiretroviral drugs. Three nucleotide sequences of HIV-1 pol gene products were selected and HIV BLAST was performed. Amino acid positions of 30 sequences were compared with HXB2 reference strain. Two sequences of protease show the major mutation with mutations sites of I54V and V82A and 8 sequences shown other mutations. One sequence of integrase with minor mutation of E157Q and 9 sequences with other mutations were inferred. This study is useful in making more accurate prediction of results with better combination Highly Active Antiretroviral Therapy (HAART) and important mutations.
authors: BioAxis DNA Research Centre Pvt. Ltd., Secunderabad, India. amit.kumar@dnares.in
authors: Amit
authors: A
authors: Kumar
authors: Chandrakant
authors: C
authors: Jadhav
mesh_terms: D000465:Algorithms; D019380:Anti-HIV Agents / Q000494:pharmacology*; D023241:Antiretroviral Therapy, Highly Active; D019295:Computational Biology; D024882:Drug Resistance, Viral / Q000235:genetics*; D015751:Genes, pol; D014644:Genetic Variation; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D019427:HIV Integrase / Q000235:genetics; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D010802:Phylogeny; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D019380:Anti-HIV Agents; D054302:pol Gene Products, Human Immunodeficiency Virus; D019427:HIV Integrase; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase; D016333:HIV Protease; C514803:p16 protease, Human immunodeficiency virus 1; C514801:p31 integrase protein, Human immunodeficiency virus 1