title: [Effects on serum estadiol and progesterone of female mice exposed to arsenic chronically].
abstract: OBJECTIVE
  By measure the changes of serumal estadiol and progesterone levels of kunming female mice, which are chronically exposed to different concentrations of arsenic trioxide, discuss the estrogen-like effects of arsenic.
  
  
  METHODS
  Select the Kunming female mice exposed to different drinking water of arsenic trioxide (0, 0.05, 0.10, 0.20, 0.40 microg/ml) for 20 weeks as the research subjects in this study. Use the method of radioimmunology to measure concentrations of serumal estadiol and progesterone of female adult mice.
  
  
  RESULTS
  Compared with the control group, there exists the changes of the concentrations of the serumal estadiol and progesterone of Km female adult mice, which are chronically exposed to the arsenic. Compared to the control group, the differences of the concentrations of the serumal estadiol in the 0.05 microg/ml group and 0.10 microg/ml group have no statistical significance (P > 0.05), the concentrations of estadiol in the 0.20 microg/ml group (P < 0.01) and 0.40 microg/ ml group (P < 0.05) decrease. Compared to the control group, the differences of the concentrations of the serumal progesterone in the 0.05 microg/ml group, 0.20 microg/ml group and 0.40 microg/ml group have no statistical significance (P > 0.05), the concentration of serumal progesterone in the 0.10 microg/ml group (P < 0.01) decrease.
  
  
  CONCLUSIONS
  Chronically arsenic exposure can interfere the levels of serumal hormones. Arsenic has the estrogen-like effects.
authors: Inner Mongolia Center for Endemic Disease Control and Research, Hohhot 010031, China. dbghy@126.com
authors: Hongyu
authors: H
authors: Guo
authors: Guang
authors: G
authors: Hao
authors: Yajuan
authors: Y
authors: Xia
authors: Wei
authors: W
authors: Guo
authors: Cunbao
authors: C
authors: Li
authors: Zhiwei
authors: Z
authors: Guo
mesh_terms: D000818:Animals; D001151:Arsenic / Q000009:adverse effects*; D052244:Endocrine Disruptors / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood*; D005260:Female; D051379:Mice; D011374:Progesterone / Q000097:blood*; D014874:Water Pollutants, Chemical / Q000009:adverse effects*
chemical_list: D052244:Endocrine Disruptors; D014874:Water Pollutants, Chemical; D011374:Progesterone; D004958:Estradiol; D001151:Arsenic