title: Dual effects of hyperprolactinemia on carrageenan-induced inflammatory paw edema in rats.
abstract: OBJECTIVE
  The effects of short-term 5-day and long-term 30-day hyperprolactinemia induced by domperidone (1.7 mg/kg/day, s.c.) or ectopic pituitary graft on the acute inflammatory response induced by carrageenan were evaluated in male rats. Both models of hyperprolactinemia effectively increased serum prolactin (PRL) levels.
  
  
  METHODS
  The volume in milliliters of inflammatory edema was measured by plethysmography 1, 2, 3, 4, 6, 8 and 24 h after carrageenan injection. The areas under the inflammatory time-response curves were compared. Additionally, the effects of hyperprolactinemia on body weight and serum corticosterone levels were evaluated.
  
  
  RESULTS
  In both domperidone-treated and pituitary graft-implanted animals, short-term 5-day hyperprolactinemia increased the inflammatory response, while long-term 30-day hyperprolactinemia had anti-inflammatory effects. Body weight was not affected by either short- or long-term hyperprolactinemia.
  
  
  CONCLUSIONS
  These results show that PRL has biphasic effects on the carrageenan-induced inflammatory response.
authors: Patologia Animal, Escuela de Medicina Veterinaria y Zootecnia, Facultad de Ciencias Agropecuarias y Recursos Naturales, Universidad de los Llanos, Villavicencio, Colombia.
authors: Julieta E
authors: JE
authors: Ochoa-Amaya
authors: Benjamin E
authors: BE
authors: Malucelli
authors: Pablo E
authors: PE
authors: Cruz-Casallas
authors: Antonia G
authors: AG
authors: Nasello
authors: Luciano F
authors: LF
authors: Felicio
authors: Maria I R
authors: MI
authors: Carvalho-Freitas
mesh_terms: D000818:Animals; D001835:Body Weight; D002351:Carrageenan / Q000633:toxicity; D003345:Corticosterone / Q000097:blood; D004487:Edema / Q000139:chemically induced / Q000276:immunology* / Q000378:metabolism; D006614:Hindlimb / Q000473:pathology; D006966:Hyperprolactinemia / Q000276:immunology* / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology* / Q000378:metabolism; D007509:Irritants / Q000633:toxicity; D008297:Male; D015213:Neuroimmunomodulation / Q000502:physiology*; D010991:Plethysmography; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007509:Irritants; D002351:Carrageenan; D011388:Prolactin; D003345:Corticosterone