title: Over-represented localized sequence motifs in ribosomal protein gene promoters of basal metazoans.
abstract: Equimolecular presence of ribosomal proteins (RPs) in the cell is needed for ribosome assembly and is achieved by synchronized expression of ribosomal protein genes (RPGs) with promoters of similar strengths. Over-represented motifs of RPG promoter regions are identified as targets for specific transcription factors. Unlike RPs, those motifs are not conserved between mammals, drosophila, and yeast. We analyzed RPGs proximal promoter regions of three basal metazoans with sequenced genomes: sponge, cnidarian, and placozoan and found common features, such as 5'-terminal oligopyrimidine tracts and TATA-boxes. Furthermore, we identified over-represented motifs, some of which displayed the highest similarity to motifs abundant in human RPG promoters and not present in Drosophila or yeast. Our results indicate that humans over-represented motifs, as well as corresponding domains of transcription factors, were established very early in metazoan evolution. The fast evolving nature of RPGs regulatory network leads to formation of other, lineage specific, over-represented motifs.
authors: Department of Molecular Biology, Rudjer Boskovic Institute, Zagreb, Croatia.
authors: Drago
authors: D
authors: Perina
authors: Marina
authors: M
authors: Korolija
authors: Maša
authors: M
authors: Roller
authors: Matija
authors: M
authors: Harcet
authors: Branka
authors: B
authors: Jeličić
authors: Andreja
authors: A
authors: Mikoč
authors: Helena
authors: H
authors: Cetković
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012269:Ribosomal Proteins / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment
chemical_list: D012269:Ribosomal Proteins