title: Genetic interactions in cancer progression and treatment.
abstract: As cancer cell genomes are unveiled at a breathtaking pace, the genetic principles at play in cancer are emerging in all their complexity, prompting the assessment of classical genetic interaction models. Here, we discuss the implications of these findings for cancer progression and heterogeneity and for the development of new therapeutic approaches.
authors: The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK. alan.ashworth@icr.ac.uk
authors: Alan
authors: A
authors: Ashworth
authors: Christopher J
authors: CJ
authors: Lord
authors: Jorge S
authors: JS
authors: Reis-Filho
mesh_terms: D000818:Animals; D018450:Disease Progression; D004843:Epistasis, Genetic; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000503:physiopathology