title: First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
abstract: Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLö-7.
authors: CNRS UMR 6014-COBRA & FR 3038, IRCOF, Rue Lucien Tesnière, 76821 Mont Saint Aignan, France.
authors: Guillaume
authors: G
authors: Mercey
authors: Tristan
authors: T
authors: Verdelet
authors: Géraldine
authors: G
authors: Saint-André
authors: Emilie
authors: E
authors: Gillon
authors: Alain
authors: A
authors: Wagner
authors: Rachid
authors: R
authors: Baati
authors: Ludovic
authors: L
authors: Jean
authors: Florian
authors: F
authors: Nachon
authors: Pierre-Yves
authors: PY
authors: Renard
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D015394:Molecular Structure; D009768:Obidoxime Chloride / Q000378:metabolism; D010755:Organophosphates / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry; D011725:Pyridines / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D012999:Soman / Q000378:metabolism
chemical_list: D002800:Cholinesterase Inhibitors; D010755:Organophosphates; D009943:Organophosphorus Compounds; D010091:Oximes; D011725:Pyridines; D011726:Pyridinium Compounds; C058577:HLo 7; D009768:Obidoxime Chloride; D012999:Soman; D000110:Acetylcholinesterase; C022870:asoxime chloride; C009374:tabun