title: Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: an in vivo SPECT study.
abstract: The biological basis of the association between cannabis-induced dopamine dysregulation and psychosis remains poorly understood. This (123)I-IBZM SPECT study assessed striatal dopamine D2 receptor (D2R) binding in 37 untreated first-episode psychosis (FEP) subjects, and 18 healthy controls. The aim was to examine if there were differences between FEP subjects with (n=14) and without (n=23) cannabis use in uptake ratios in the D2R. Striatal/Frontal cortex (S/F) uptake ratios were obtained. Healthy controls showed the lowest D2R binding ratios. No differences were found in S/F ratios between users and non-users, suggesting similar dopaminergic mechanisms underlying psychotic symptoms in both groups.
authors: Department of Psychiatry, Hospital Universitari Mútua Terrassa, Universitat de Barcelona (UB), Plaça Dr. Robert, 5. 08221, Terrassa, Barcelona, Spain. gemmasl@msn.com
authors: Gemma
authors: G
authors: Safont
authors: Iluminada
authors: I
authors: Corripio
authors: María J
authors: MJ
authors: Escartí
authors: Maria J
authors: MJ
authors: Portella
authors: Víctor
authors: V
authors: Pérez
authors: Marc
authors: M
authors: Ferrer
authors: Valle
authors: V
authors: Camacho
authors: Rosa B
authors: RB
authors: Sauras
authors: Anna
authors: A
authors: Alonso
authors: Eva M
authors: EM
authors: Grasa
authors: Belén
authors: B
authors: Arranz
authors: Luis
authors: L
authors: San
authors: Rosa
authors: R
authors: Dueñas
authors: Ignasi
authors: I
authors: Carrió
authors: Enric
authors: E
authors: Álvarez
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001549:Benzamides; D002188:Cannabis / Q000378:metabolism*; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D018492:Dopamine Antagonists; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D018709:Statistics, Nonparametric; D015899:Tomography, Emission-Computed, Single-Photon; D055815:Young Adult
chemical_list: D001549:Benzamides; D018492:Dopamine Antagonists; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide