title: Effectiveness of treatments for severe sepsis: data from the bundle implementation programs.
abstract: In severe sepsis, several studies, a recent meta--analysis and studies evaluating multifaceted strategies for quality improvement, have shown that bundled care can improve survival. Here, the effectiveness of treatments for severe sepsis included in the bundles was analyzed. Despite the observational design of the studies, possible biases are minimized using propensity scores and other adjustments. The results of are very consistent: early sepsis recognition with the administration of broad-spectrum antibiotics in all patients and specific treatments for patients in shock, such as activated protein C, or those on mechanical ventilation play a role in improving sepsis outcome. Hospitals should recognize this new evidence and design strategies to guarantee bundled care for severe sepsis.
authors: Critical Care Center, Hospital de Sabadell, CIBER Enfermedades Respiratorias, Instituto Universitario Parc Tauli, Universidad Autónoma de Barcelona, Spain. rferrer@tauli.cat
authors: R
authors: R
authors: Ferrer
authors: A
authors: A
authors: Artigas
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D003131:Combined Modality Therapy; D019317:Evidence-Based Medicine; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D017052:Hospital Mortality; D006801:Humans; D015201:Meta-Analysis as Topic; D011486:Protein C / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D012129:Respiratory Function Tests; D018805:Sepsis / Q000628:therapy*; D012772:Shock, Septic / Q000628:therapy; D013534:Survival; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D001786:Blood Glucose; D005343:Fibrinolytic Agents; D011486:Protein C; D011994:Recombinant Proteins; C421124:drotrecogin alfa activated