title: Synthesis of saturated 1,4-benzodiazepines via Pd-catalyzed carboamination reactions.
abstract: A new synthesis of 1,4-benzodiazepines and 1,4-benzodiazepin-5-ones is reported. The Pd-catalyzed coupling of N-allyl-2-aminobenzylamine derivatives with aryl bromides affords the heterocyclic products in good yield, and substrates bearing allylic methyl groups are transformed to cis-2,3-disubstituted products with >20:1 dr.
authors: Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.
authors: Joshua D
authors: JD
authors: Neukom
authors: Alvin S
authors: AS
authors: Aquino
authors: John P
authors: JP
authors: Wolfe
mesh_terms: D000586:Amination; D001569:Benzodiazepines / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001569:Benzodiazepines; D010165:Palladium