title: Adverse maternal and perinatal outcomes in women with previous preeclampsia: a prospective study.
abstract: OBJECTIVE
  The purpose of this study was to assess recurrence rates of preeclampsia and neonatal outcomes in women with a history of preeclampsia that required preterm delivery.
  
  
  METHODS
  Five hundred women with previous preeclampsia that required delivery at <37 weeks' gestation were followed prospectively.
  
  
  RESULTS
  Preeclampsia reoccurred in 117 women (23%). Predictive factors included black (odds ratio [OR], 2.29; 95% confidence interval [CI], 1.16-4.53) or Asian (OR, 2.98; 95% CI, 1.33-6.59) ethnicity, enrollment systolic blood pressure of >130 mm Hg (OR, 2.89; 95% CI, 1.52-5.50), current antihypertensive use (OR, 6.39; 95% CI, 2.38-17.16), and proteinuria of ≥2+ on enrollment urinalysis (OR, 12.35; 95% CI, 3.45-44.21). Women who previously delivered at <34 weeks' gestation were more likely to deliver preterm again (29% vs 17%; relative risk, 1.69; 95% CI, 1.19-2.40) than were those women with previous delivery between 34 and 37 weeks' gestation.
  
  
  CONCLUSIONS
  Although this study confirms that women with previous preeclampsia that required early delivery are at high risk of the development of preeclampsia, the study identifies risk factors for recurrence and illustrates that women with previous preeclampsia are at greater risk of adverse neonatal outcome.
authors: Maternal and Fetal Research Unit, Division of Women's Health, King's College London School of Medicine, London, England, UK.
authors: Kate
authors: K
authors: Bramham
authors: Annette L
authors: AL
authors: Briley
authors: Paul
authors: P
authors: Seed
authors: Lucilla
authors: L
authors: Poston
authors: Andrew H
authors: AH
authors: Shennan
authors: Lucy C
authors: LC
authors: Chappell
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors