title: TRFolder: computational prediction of novel telomerase RNA structures in yeast genomes.
abstract: The identification of Telomerase RNAs (TRs) has been difficult owing to their rapid evolutionary divergence. The common core structure found in all known TRs contains a pseudoknot and a triple helix, which are beyond the capability of existing RNA-structure-profiling techniques. We describe a novel approach to predict the structure of key TR features and to aid the identification of TRs in genomes, using a program we developed, TRFolder. We applied our method to confirm and improve previously studied core structures from Saccharomyces and Kluyveromyces TRs. We made novel structural predictions of core elements of the TRs from Schizosaccharomyces pombe, Candida albicans, and several other yeast species.
authors: Department of Genetics, University of Georgia, Athens, GA 30602, USA. guoll@uga.edu
authors: Leilei
authors: L
authors: Guo
authors: Dong
authors: D
authors: Zhang
authors: Yingfeng
authors: Y
authors: Wang
authors: Russell L
authors: RL
authors: Malmberg
authors: Michael
authors: M
authors: McEachern
authors: Liming
authors: L
authors: Cai
mesh_terms: D001483:Base Sequence; D002176:Candida albicans / Q000235:genetics; D019295:Computational Biology; D003198:Computer Simulation; D016681:Genome, Fungal; D007716:Kluyveromyces / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000235:genetics*; D012331:RNA, Fungal / Q000737:chemistry* / Q000235:genetics*; D012440:Saccharomyces / Q000235:genetics; D012568:Schizosaccharomyces / Q000235:genetics; D012984:Software; D019098:Telomerase / Q000737:chemistry* / Q000235:genetics*; D015003:Yeasts / Q000235:genetics*
chemical_list: D012331:RNA, Fungal; C422952:telomerase RNA; D012313:RNA; D019098:Telomerase