title: Association between echocardiographic parameters and brain natriuretic peptide levels in treated hypertensive patients.
abstract: We examined which echocardiographic parameter correlated best with plasma brain natriuteric peptide (BNP) levels in treated hypertensive patients. Enrolled in the study were 122 treated hypertensive patients (70 ± 9 y). The left ventricular mass index and left atrial dimension (LAD) were measured using echocardiography as indexes of left ventricular hypertrophy and left atrial enlargement, respectively. Among all the echocardiographic parameters, LAD correlated best with BNP (r = 0.343, p < 0.001). Stepwise regression analysis showed that LAD (β coefficient = 0.513, p < 0.001) was independently associated with BNP. Left atrial enlargement, rather than left ventricular hypertrophy, may be clinically useful for predicting elevated BNP levels in treated hypertensive patients.
authors: Department of Integrated Medicine, Kagawa University, Kagawa, Japan. masugata@med.kagawa-u.ac.jp
authors: Hisashi
authors: H
authors: Masugata
authors: Shoichi
authors: S
authors: Senda
authors: Koji
authors: K
authors: Murao
authors: Hiroyuki
authors: H
authors: Okuyama
authors: Michio
authors: M
authors: Inukai
authors: Naohisa
authors: N
authors: Hosomi
authors: Yasuyoshi
authors: Y
authors: Iwado
authors: Takahisa
authors: T
authors: Noma
authors: Masakazu
authors: M
authors: Kohno
authors: Fuminori
authors: F
authors: Goda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy*; D006984:Hypertrophy; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012189:Retrospective Studies; D014463:Ultrasonography
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D015415:Biomarkers; D020097:Natriuretic Peptide, Brain