title: Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones.
abstract: A number of mono- or diaminoalkylated indeno[1,2-c]isoquinolin-5,11-diones analogs of 1 were synthesized and evaluated for their DNA binding affinities, topoisomerase inhibition properties and antiproliferative activities against human cancer cell lines (HL60). Impact of the side chain connected to the aromatic D ring and to the N6 lactam position on the biological profile will be discussed.
authors: EA CMF 4478, Université Lille 1-Lille Nord de France, Bat C3(2), Cité Scientifique, 59655 Villeneuve d'Ascq Cedex, France. gangahn3@gmail.com
authors: Gang
authors: G
authors: Ahn
authors: Nadège
authors: N
authors: Schifano-Faux
authors: Jean-François
authors: JF
authors: Goossens
authors: Brigitte
authors: B
authors: Baldeyrou
authors: Axel
authors: A
authors: Couture
authors: Pierre
authors: P
authors: Grandclaudon
authors: Amélie
authors: A
authors: Lansiaux
authors: Adina
authors: A
authors: Ryckebusch
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004264:DNA Topoisomerases, Type I / Q000737:chemistry* / Q000378:metabolism; D004250:DNA Topoisomerases, Type II / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D059005:Topoisomerase II Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D044366:Transition Temperature
chemical_list: D000970:Antineoplastic Agents; D007546:Isoquinolines; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II