title: Protective role of tea polyphenols in combination against radiation-induced haematopoietic and biochemical alterations in mice.
abstract: The purpose of this study was to investigate the radioprotective effects of tea polyphenols (TPs) in various combinations against radiation-induced damage in mice. Mice were divided into different groups: non-irradiated control, irradiated control, amifostine (43.6 mg/kg, i.v. 30 min before irradiation; positive control) and various combinations of tea polyphenols in different doses. The radioprotective effect on the haematopoietic system, serum cytokines and endogenous antioxidant enzymes were studied. TP50, containing approximately 50% of (-)-epigallochatechin-3-gallate in addition to other catechins, showed the greatest radioprotective effect against radiation-induced changes in haematological parameters (red blood cell count, white blood cell count and haemoglobin), and maintained the spleen and thymus indices unchanged (spleen or thymus weight/body weight × 1000). Tea polyphenols also significantly decreased radiation-induced lipid peroxidation (malondialdehyde levels), elevated endogenous antioxidant enzymes (superoxide dismutase) and reduced the serum cytokines which were elevated in radiation-induced toxicity. This evidence shows the potential of tea polyphenols, particularly in the combination found in TP50, as radioprotectors in mice, especially regarding recovery of the haematopoietic system, antioxidant potential activity and reduction of inflammatory cytokines.
authors: Department of Clinical Pharmacology and Pharmacy, Centre of Pharmacy, Chinese PLA General Hospital, Beijing, 100853, China.
authors: Yuan
authors: Y
authors: Hu
authors: Jing-Jing
authors: JJ
authors: Cao
authors: Ping
authors: P
authors: Liu
authors: Dai-Hong
authors: DH
authors: Guo
authors: Ya-Ping
authors: YP
authors: Wang
authors: Jian
authors: J
authors: Yin
authors: Ying
authors: Y
authors: Zhu
authors: Khalid
authors: K
authors: Rahman
mesh_terms: D000818:Animals; D002392:Catechin / Q000494:pharmacology; D016207:Cytokines / Q000032:analysis; D005720:Gamma Rays; D006413:Hematopoietic System / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000032:analysis; D051379:Mice; D015394:Molecular Structure; D059808:Polyphenols / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects; D013482:Superoxide Dismutase / Q000032:analysis; D013662:Tea / Q000737:chemistry*; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D016207:Cytokines; D059808:Polyphenols; D011837:Radiation-Protective Agents; D013662:Tea; D008315:Malondialdehyde; D002392:Catechin; D013482:Superoxide Dismutase