title: Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men.
abstract: Ghrelin, an acylated peptide produced predominantly in the stomach, stimulates feeding and growth hormone (GH) secretion via interaction with the GH secretagogue receptor. Ghrelin molecules are present in two major endogenous forms, an acylated form (ghrelin) and a des-acylated form (des-acyl ghrelin). Recent studies indicated that aerobic exercise did not change plasma total ghrelin levels, however, dynamics of circulating ghrelin and des-acyl ghrelin during aerobic exercise remains unclear. The purpose of this study is to examine the effects of moderate intensity exercise on plasma ghrelin and des-acyl ghrelin concentrations, and to investigate the relationship between ghrelin molecules and other hormonal and metabolic parameters during exercise. Nine healthy males (25.2 ± 0.5 years) exercised for 60 min at 50% of their maximal oxygen consumptions. We measured the plasma concentrations of ghrelin, des-acyl ghrelin, GH, norepinephrine (NE), epinephrine (E), dopamine (DA), insulin, and glucose. Plasma ghrelin level significantly decreased during exercise, whereas plasma des-acyl ghrelin and total ghrelin levels did not change. Plasma NE, E, DA and GH levels were significantly increased during exercise. Plasma insulin level significantly decreased during exercise, and plasma glucose levels remained steady during exercise. NE, E, DA, and GH were correlated negatively with plasma ghrelin levels. These findings suggest that acute moderate exercise may suppress ghrelin release from the stomach, decrease ghrelin O-acyltransferase activity, and/or activate ghrelin utilization in peripheral tissues and that exercise-induced ghrelin suppression may be mediated by activated adrenergic system.
authors: Faculty of Medicine, Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan.
authors: Tomomi
authors: T
authors: Shiiya
authors: Hiroaki
authors: H
authors: Ueno
authors: Koji
authors: K
authors: Toshinai
authors: Takashi
authors: T
authors: Kawagoe
authors: Seiko
authors: S
authors: Naito
authors: Takuro
authors: T
authors: Tobina
authors: Yuichiro
authors: Y
authors: Nishida
authors: Munehiro
authors: M
authors: Shindo
authors: Kenji
authors: K
authors: Kangawa
authors: Hiroaki
authors: H
authors: Tanaka
authors: Masamitsu
authors: M
authors: Nakazato
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004298:Dopamine / Q000097:blood; D004837:Epinephrine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005753:Gastric Mucosa / Q000378:metabolism; D054439:Ghrelin / Q000097:blood* / Q000378:metabolism; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000097:blood
chemical_list: D001786:Blood Glucose; D054439:Ghrelin; D007328:Insulin; C422650:ghrelin, des-n-octanoyl; D019382:Human Growth Hormone; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine