title: Sedative, vasorelaxant, and cytotoxic effects of convolvulin from Ipomoea tyrianthina.
abstract: OBJECTIVE
  Ipomoea tyrianthina has been used in Mexican traditional medicine as a mild purgative, for the treatment of nervous disorders, and against tumors. In this study, the effect of convolvulin (an ether-insoluble resin glycoside) from the root of Ipomoea tyrianthina on: Central Nervous System; as spasmolytic and vasodilator; cytotoxic against cancer cell lines is evaluated.
  
  
  METHODS
  Convolvulin isolated from the root of Ipomoea tyrianthina (IT-EM) was tested on pentylentetrazole induced seizures, pentobarbital-induced hypnosis, release of GABA and glutamic acid, isolated rat aorta and ileum rings, and against Caco-2 and KB cell lines.
  
  
  RESULTS
  IT-EM increased the hypnotic effect induced by pentobarbital and the release of GABA in brain cortex of mice, but did not protect mice against pentylenetetrazole-induced convulsions. IT-EM produced a significant vasodilator effect in concentration- and endothelium-dependent manners on isolated rat aorta, but did not inhibit significantly contractions on rat ileum, colon, and jejune rings. IT-EM showed cytotoxic activity against nasopharyngeal carcinoma KB cell line.
  
  
  CONCLUSIONS
  Convolvulin (IT-EM) from Ipomoea tyrianthina has sedative effect, vasorelaxant effect in concentration- and endothelium-dependent manners, and cytotoxic activity against nasopharyngeal carcinoma KB cell line.
authors: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico. ismaelr@uaem.mx
authors: Ismael
authors: I
authors: León-Rivera
authors: Maribel
authors: M
authors: Herrera-Ruiz
authors: Samuel
authors: S
authors: Estrada-Soto
authors: María del Carmen
authors: Mdel C
authors: Gutiérrez
authors: Iván
authors: I
authors: Martínez-Duncker
authors: Gabriel
authors: G
authors: Navarrete-Vázquez
authors: María Yolanda
authors: MY
authors: Rios
authors: Berenice
authors: B
authors: Aguilar
authors: Patricia
authors: P
authors: Castillo-España
authors: Alma
authors: A
authors: Aguirre-Moreno
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D027741:Ipomoea / Q000737:chemistry*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry*; D012116:Resins, Plant / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D012116:Resins, Plant; D014665:Vasodilator Agents; C560812:convolvulin