title: Predicting age at menopause from serum antimüllerian hormone concentration.
abstract: OBJECTIVE
  We aimed to estimate age at menopause using serum antimüllerian hormone (AMH) concentration.
  
  
  METHODS
  We randomly selected 266 study participants from a pool of 1,265 eligible women in the Tehran Lipid and Glucose Study cohort. We measured AMH levels three times at about 3-year intervals. There were 63 occurrences of menopause in our participants over an average of 6-year follow-up. We built an accelerated failure time model using serum AMH level at the start of follow-up to estimate age at menopause. The goodness of fit for the model was tested using Cox-Snell residuals and the Bland-Altman plot.
  
  
  RESULTS
  We estimated ages at menopause for different levels of serum AMH concentration among women aged 20 to 49 years. For those who reached menopause, serum AMH concentrations about 6 years before the event provided fairly accurate estimates of the age at menopause. The Bland-Altman plot showed an acceptable agreement between predicted and observed values.
  
  
  CONCLUSIONS
  Serum AMH concentrations can reasonably forecast the age at menopause for individual women.
authors: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ramezani@endocrine.ac.ir
authors: Fahimeh Ramezani
authors: FR
authors: Tehrani
authors: Nezhat
authors: N
authors: Shakeri
authors: Masoud
authors: M
authors: Solaymani-Dodaran
authors: Fereidoun
authors: F
authors: Azizi
mesh_terms: D000328:Adult; D017677:Age Distribution; D054304:Anti-Mullerian Hormone / Q000032:analysis / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests; D013997:Time Factors
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone