title: Angiogenesis-related molecular targets in esophageal cancer.
abstract: BACKGROUND
  Angiogenesis has become an appealing target in cancer therapy due to its fundamental role in cancer growth and metastasis. A number of angiogenesis-related molecules are under investigation, with some already in clinical practice with various results. The effort to present and discuss the current status of the research on the angiogenesis-related molecular targets will lead to improved clinical strategies and outcomes for patients with esophageal cancer (EC).
  
  
  METHODS
  This review summarizes the recent advances in angiogenesis-related targets in EC, and also analyzes the clinical and therapeutic applications they provide. We envisage future developments towards the anti-angiogenic strategy of molecular targets and their potential applications to cancer treatment.
  
  
  CONCLUSIONS
  Angiogenesis-related targets can be used as a useful therapeutic tool for EC. More investigations should be performed to promote the success of anti-angiogenic therapy in clinical trials.
authors: Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi'an, Shaanxi Province, China. hongliu180@126.com
authors: Liu
authors: L
authors: Hong
authors: Shujun
authors: S
authors: Li
authors: Yu
authors: Y
authors: Han
authors: Jianjun
authors: J
authors: Du
authors: Hongwei
authors: H
authors: Zhang
authors: Jipeng
authors: J
authors: Li
authors: Qingchuan
authors: Q
authors: Zhao
authors: Kaichun
authors: K
authors: Wu
authors: Daiming
authors: D
authors: Fan
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D002986:Clinical Trials as Topic; D004938:Esophageal Neoplasms / Q000098:blood supply* / Q000188:drug therapy*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000188:drug therapy
chemical_list: D020533:Angiogenesis Inhibitors