title: Relationships between changes in pain severity and other patient-reported outcomes: an analysis in patients with posttraumatic peripheral neuropathic pain.
abstract: BACKGROUND
  The objective of this study is to use the pain numeric rating scale (NRS) to evaluate associations between change in pain severity and changes in sleep, function, and mood assessed via patient-reported outcomes (PROs) in patients with posttraumatic pain.
  
  
  METHODS
  This is a secondary analysis of a clinical trial evaluating pregabalin in patients with posttraumatic peripheral neuropathic pain (N = 254). Regression models were used to determine associations between changes in pain (0-10 NRS) as the predictor and scores on the following PRO measures as the outcome: Pain Interference Index; Hospital Anxiety and Depression Scale anxiety and depression subscales; Medical Outcomes Study-Sleep Scale 9-item Sleep Problems Index and Sleep Disturbance subscale; and Daily Sleep Interference Scale (0-10 NRS).
  
  
  RESULTS
  Change in pain severity showed clear, direct relationships with changes in function, anxiety, depression, and sleep PROs, all of which were statistically significant (P <.001). Results from subgroup analyses (≥30% or ≥50% pain responders, pregabalin or placebo treatment, age ≤ 51 years or > 51 years) tended to be consistent with results from the overall sample.
  
  
  CONCLUSIONS
  Overall, a direct relationship exists between pain and various aspects of patient's well-being and functioning, which can provide a quantitative assessment of how improvements in pain may be expected to relate to other patient outcomes. (http://ClinicalTrials.gov Identifier number NCT00292188; EudraCT #2005-003048-78).
authors: Pain Clinic, Amphia Hospital, Breda, The Netherlands. rvseventer@amphia.nl
authors: Robert
authors: R
authors: van Seventer
authors: Michael
authors: M
authors: Serpell
authors: Flemming W
authors: FW
authors: Bach
authors: Bart
authors: B
authors: Morlion
authors: Gergana
authors: G
authors: Zlateva
authors: Andrew G
authors: AG
authors: Bushmakin
authors: Joseph C
authors: JC
authors: Cappelleri
authors: Meryem
authors: M
authors: Nimour
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D001007:Anxiety / Q000209:etiology; D003863:Depression / Q000209:etiology; D006801:Humans; D009437:Neuralgia / Q000150:complications* / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D010147:Pain Measurement / Q000187:drug effects; D000069583:Pregabalin; D011788:Quality of Life; D057566:Self Report; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D012893:Sleep Wake Disorders / Q000209:etiology; D014947:Wounds and Injuries / Q000150:complications*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid