title: Polymyositis and dermatomyositis: pathophysiology.
abstract: Recent advances have increased the understanding of the pathogenesis of polymyositis and dermatomyositis. Clearly, the pathogenesis is complex, and adaptive (eg, autoimmune) and innate and nonimmune pathways play a role in the disease mechanisms, but the relative contribution may vary between patients and in different phases of the disease. Phenotyping patients using autoantibody profiling has resulted in information on molecular pathways that may be relevant in certain subsets of patients with polymyositis or dermatomyositis, but combining the autoantibody profiles with molecular signatures of innate and nonimmune mechanisms would enhance our ability to classify, diagnose, and treat these disorders more effectively.
authors: Research Center for Genetic Medicine, Children's National Medical Center and Department of Integrative Systems Biology, The George Washington University Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA.
authors: Kanneboyina
authors: K
authors: Nagaraju
authors: Ingrid E
authors: IE
authors: Lundberg
mesh_terms: D056704:Adaptive Immunity; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology*; D015551:Autoimmunity; D003882:Dermatomyositis / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007113:Immunity, Innate; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology; D009336:Necrosis; D017285:Polymyositis / Q000276:immunology / Q000503:physiopathology*
chemical_list: D001323:Autoantibodies