title: [Study of antiviral activity of extracts obtained from basidial fungi against influenza viruses of different subtypes in experiments in vitro and in vivo].
abstract: OBJECTIVE
  To study antiviral activity of extracts obtained from basidial fungi against influenza viruses of different subtypes.
  
  
  METHODS
  Antiviral activity of extracts obtained from basidial fungi against influenza virus A/chicken/Kurgan/05/2005 (H5N1) was determined in in vitro experiments. Changes in infectiousness of pandemic influenza virus A/Moscow/226/2009 (HIN1)v caused by extracts of basidial fungi was studied in experiments in vitro and in vivo.
  
  
  RESULTS
  Seventy water extracts of basidial fungi were studied, of which 10 were able to inhibit infectiousness of influenza virus strain A/ chicken/Kurgan/05/2005 (H5N1) in MDCK cell culture. Also, several studied extracts decreased infectiousness of pandemic influenza virus strain A/ Moscow/226/2009 (H1N1)v in MDCK cells and inhibit its reproduction in lungs of infected mice.
  
  
  CONCLUSIONS
  High antiviral activity of extracts obtained from basidial fungi against influenza viruses opens perspectives for development of drugs with preventive and treatment effects.
authors: A S
authors: AS
authors: Kabanov
authors: T A
authors: TA
authors: Kosogova
authors: L N
authors: LN
authors: Shishkina
authors: T V
authors: TV
authors: Tepliakova
authors: M O
authors: MO
authors: Skarnovich
authors: N A
authors: NA
authors: Mazurkova
authors: L I
authors: LI
authors: Puchkova
authors: E M
authors: EM
authors: Malkova
authors: E A
authors: EA
authors: Stavskiĭ
authors: I G
authors: IG
authors: Drozdov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D045424:Complex Mixtures / Q000737:chemistry / Q000494:pharmacology*; D004285:Dogs; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000254:growth & development / Q000378:metabolism*; D053124:Influenza A Virus, H5N1 Subtype / Q000254:growth & development / Q000378:metabolism*; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D045424:Complex Mixtures