title: Sensory nerve conduction in the caudal nerves of rats with diabetes.
abstract: OBJECTIVE
  To investigate sensory nerve conduction of the caudal nerve in normal and diabetic rats.
  
  
  METHODS
  Diabetes was induced in twenty 8-weeks old Wistar male rats. Twenty normal rats served as controls. Caudal nerve conduction studies were made before diabetes induction and the end of each week for six consecutive weeks. The caudal nerve was stimulated distally and nerve potentials were recorded proximally on the animal's tail using common "alligator" clips as surface electrodes.
  
  
  RESULTS
  After induction, nerve conduction velocities (NCV) increased slower in the diabetic than in the control group. Sensory nerve action potentials (SNAP) conduction velocities increased slower in the diabetic than in the control group (slope of regression line: 0.5 vs 1.3m/s per week; NCV in the 15(th) week = 39±3m/s vs 44±4m/s). Tukey's tests showed differences between groups at the 11th, 13(th) and 15(th) weeks old. From the 10(th) week on, SNAP amplitudes increased faster in the diabetic than in the control group (slopes of the regression line: 10 vs 8µV per week; SNAP amplitudes in the 15(th) week: 107±23µV vs 85±13µV). Differences at the 12(th), 13(th) and 15(th) weeks were significant.
  
  
  CONCLUSIONS
  In diabetic rats nerve conduction velocities were slower whereas amplitudes were larger than in normal rats.
authors: Postgraduate Program in Neuropsychiatry and Behavioural Sciences, UFPE, Recife, PE, Brazil. celinacordeiro@hotmail.com
authors: Celina Cordeiro de
authors: CC
authors: Carvalho
authors: Juliana Netto
authors: JN
authors: Maia
authors: Otávio Gomes
authors: OG
authors: Lins
authors: Sílvia Regina Arruda de
authors: SR
authors: Moraes
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013623:Tail / Q000294:innervation*