title: [Cytomegalovirus infection in patients with ulcerative colitis].
abstract: OBJECTIVE
  Adjusting therapy of patients with ulcerative colitis (UC) regarding their cytomegalovirus (CMV)--status.
  
  
  METHODS
  40 patients were included, mean age--44.3 +/- 3.2 yo. DNA CMV was detected in mucosal tissue samples from rectum using real-time PCR.
  
  
  RESULTS
  4 (10%) were CMV-positive. CMV-positive status rate was higher among patients on therapy with immunomodulators 3 (23.1%) vs 1 in patients on steroids and/or salicylates. There was significantly higher rate of severe disease and steroid dependence among CMV-positive patients than among CMV-negative: 75% vs 13.9%, 75% vs 8.3% correspondently.
  
  
  CONCLUSIONS
  CMV-infection is associated with severe and steroid-dependent UC.
authors: E N
authors: EN
authors: Baryshnikov
authors: V N
authors: VN
authors: Drozdov
authors: I S
authors: IS
authors: Shuliat'ev
authors: A I
authors: AI
authors: Parfenov
authors: L B
authors: LB
authors: Lazebnik
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D000069285:Infliximab; D008297:Male; D012007:Rectum / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012459:Salicylates / Q000008:administration & dosage / Q000627:therapeutic use; D012720:Severity of Illness Index
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D007155:Immunologic Factors; D012459:Salicylates; D000069285:Infliximab; D001379:Azathioprine