title: Synthesis and biological evaluation of some schiff bases of [4-(amino)-5-phenyl-4H-1, 2,4-triazole-3-thiol].
abstract: The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using water as solvent under reflux condition for 3-4 h. The compound which has been synthesized successfully was subjected to addition reaction with different aldehydes to synthesize Schiff bases. The compounds were confirmed by physical parameters (solubility, melting point), chromatographic methods (TLC) and at last spectroscopic methods (IR, NMR, and Mass). In order to ascertain the pharmaceutical application, the selective pharmacological screening of the derivatives was carried out according to the standard procedures. The compounds were screened for their antianxietic activity by elevated plus maze method, antidepressant activity by forced swim test. Among the synthesized compounds, the Schiff bases of benzaldehyde (5e), furfuraldehyde (5d) and 2,4-dichloro benzaldehyde (5a) showed extremely significant activities. Results indicate that these compounds may be potential candidates for managing CNS disorders. However further studies are required to substantiate the same which are underway in our lab.
authors: Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Rocklands, Ooty, India. jubiejawahar@gmail.com
authors: Selvaraj
authors: S
authors: Jubie
authors: Pranabesh
authors: P
authors: Sikdar
authors: Shanish
authors: S
authors: Antony
authors: Rajagopal
authors: R
authors: Kalirajan
authors: Byran
authors: B
authors: Gowramma
authors: Subramanian
authors: S
authors: Gomathy
authors: Kannan
authors: K
authors: Elango
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D015394:Molecular Structure; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C558141:4-(amino)-5-phenyl-4H-1,2,4-triazole-3-thiol; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D012545:Schiff Bases; D014230:Triazoles