title: Caspase-8: clipping off RIG-I signaling.
abstract: Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling.
authors: Institut für Molekulare Immunologie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
authors: Susanne
authors: S
authors: Roth
authors: Jürgen
authors: J
authors: Ruland