title: Ginsenoside Rg3 inhibits CXCR4 expression and related migrations in a breast cancer cell line.
abstract: BACKGROUND
  Ginsenoside Rg3 is an extract from the natural product ginseng. Previous studies have linked Rg3 with anti-metastasis of cancer in vivo and in vitro. CXC receptor 4 (CXCR4) is a vital molecule in migration and homing of cancer to the docking regions.
  
  
  METHODS
  In this study, the effects of Rg3 on CXCR4 expression were investigated in a breast cancer cell line. Immunohistochemistry, chemotaxis and wound healing mobility assays were performed in cultured MDA-MB-231 cells.
  
  
  RESULTS
  At a dosage without obvious cytotoxicity, Rg3 treatment elicits a weak CXCR4 stain color, decreases the number of migrated cells in CXCL12-elicited chemotaxis and reduces the width of the scar in wound healing.
  
  
  CONCLUSIONS
  This work suggests that Rg3 is a new CXCR4 inhibitor from a natural product.
authors: College of Biological and Environmental Engineering, Zhejiang University of Technology, 18 Chao-Wang Road, Hangzhou, 310014, China.
authors: Xiao-Ping
authors: XP
authors: Chen
authors: Lin-Lin
authors: LL
authors: Qian
authors: Hong
authors: H
authors: Jiang
authors: Jiang-Hua
authors: JH
authors: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D054377:Chemokine CXCL12 / Q000378:metabolism; D002633:Chemotaxis / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D036145:Ginsenosides / Q000494:pharmacology*; D006801:Humans; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D019718:Receptors, CXCR4; C097367:ginsenoside Rg3