title: Myocarditis: a defect in central immune tolerance?
abstract: Myocarditis, or inflammation of the heart, is a potentially devastating disease that can result from both viral infection and autoimmune attack of self antigens in the heart. In the current issue of the JCI, Lv and colleagues use a genetically susceptible mouse model to show that myocarditis is a T cell-mediated autoimmune disease that occurs due to insufficient thymic negative selection of α-myosin-reactive T cells.
authors: Diabetes Center, UCSF, San Francisco, California 94143, USA.
authors: Todd C
authors: TC
authors: Metzger
authors: Mark S
authors: MS
authors: Anderson
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006683:HLA-DQ Antigens / Q000235:genetics; D007108:Immune Tolerance; D051379:Mice; D016688:Mice, Inbred NOD; D008822:Mice, Transgenic; D009205:Myocarditis / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D013601:T-Lymphocytes / Q000276:immunology; D024723:Ventricular Myosins / Q000276:immunology
chemical_list: D006683:HLA-DQ Antigens; C109756:HLA-DQ8 antigen; D024723:Ventricular Myosins