title: The significance of strong histone deacetylase 1 expression in the progression of prostate cancer.
abstract: OBJECTIVE
  Histone deacetylases (HDACs) play important roles in many types of cancer. Recently, it has been reported that HDAC1 expression in prostate cancer is significantly higher than in benign prostate cell lines and tissues. The expression of HDAC1 in association with the clinicopathological data was investigated to define its functional and pathological roles in prostate cancer.
  
  
  RESULTS
  HDAC1 expression was examined immunohistochemically in 148 patients with prostate cancer. Strong expression of HDAC1 in benign prostate glands, high-grade prostatic intraepithelial neoplasia (PIN) and prostate cancer was observed in 17/148 (11%), 19/71 (27%) and 69/148 (47%) patients. Strong HDAC1 expression was correlated with high Gleason score (P = 0.025) and high pT stage (P = 0.012). Patients with strong HDAC1 expression had higher biochemical recurrence rates (P = 0.0010). Furthermore, strong HDAC1 expression had a significant impact on patient biochemical recurrence rates in multivariate analysis (P = 0.004).
  
  
  CONCLUSIONS
  These results indicate that overexpression of HDAC1 contributes to progression and poor prognosis in prostate cancer. The findings may play an important role in the emergence of effective new approaches for therapy and prognostic markers of prostate cancer.
authors: Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: YooHyun
authors: Y
authors: Song
authors: Masaki
authors: M
authors: Shiota
authors: Sadafumi
authors: S
authors: Tamiya
authors: Kentaro
authors: K
authors: Kuroiwa
authors: Seiji
authors: S
authors: Naito
authors: Masazumi
authors: M
authors: Tsuneyoshi
mesh_terms: D000368:Aged; D018450:Disease Progression; D056284:Histone Deacetylase 1 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D019048:Prostatic Intraepithelial Neoplasia / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000473:pathology
chemical_list: C110550:HDAC1 protein, human; D056284:Histone Deacetylase 1