title: Synchrotron radiation infrared microspectroscopy to assess the activity of vancomycin against endocarditis vegetation bacteria.
abstract: Infrared microspectroscopy was used to show that vancomycin alters infrared spectra of endocarditis vegetation bacteria, and that vancomycin effects on bacterial biochemical contents are unevenly distributed between peripheral and central areas of bacterial masses. Infrared microspectroscopy is useful to study the activity of antibacterial agents against bacteria in tissues.
authors: Université de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, Nantes, France. eric.batard@chu-nantes.fr
authors: Eric
authors: E
authors: Batard
authors: Frédéric
authors: F
authors: Jamme
authors: Emmanuel
authors: E
authors: Montassier
authors: Dominique
authors: D
authors: Bertrand
authors: Jocelyne
authors: J
authors: Caillon
authors: Gilles
authors: G
authors: Potel
authors: Paul
authors: P
authors: Dumas
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D018533:Biomass; D004696:Endocarditis / Q000382:microbiology*; D008826:Microbial Sensitivity Tests / Q000379:methods*; D011827:Radiation; D013055:Spectrophotometry, Infrared / Q000379:methods*; D017356:Synchrotrons; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin