title: Modulation of antibody effector function.
abstract: Several novel technologies have evolved over the last decade for the modification of antibodies to enhance their inherent effector functions. All focus on the constant Fc domain and utilize either amino acid substitutions or glycoform perturbations to modulate their interaction with Fc receptors and the effector cells that bear them. We review these technologies with an emphasis on their validation with animal models and human clinical data.
authors: Xencor, Inc, Monrovia, CA 91016, USA. jrd@xencor.com
authors: John R
authors: JR
authors: Desjarlais
authors: Greg A
authors: GA
authors: Lazar
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D015195:Drug Design; D006801:Humans
chemical_list: D000906:Antibodies; D003165:Complement System Proteins