title: Maternal effect and familial aggregation in a type 2 diabetic Moroccan population.
abstract: The aim of this study is to evaluate the degree of familial aggregation of type 2 diabetes mellitus in Morocco and to investigate transmission patterns of the disease and their relationships with patients' clinical profiles. Family history of diabetes and clinical data were collected from 232 unrelated type 2 diabetic Moroccan patients. Diabetes status was recorded for first degree (parents, siblings) and second degree relatives (aunts and uncles from both maternal and paternal sides). Among studied subjects, 50% reported at least one relative with diabetes and 24% had at least one parent with diabetes. Familial aggregation of type 2 diabetes was prominent and more important among first degree relatives than second degree relatives (P < 0.01). Moreover, diabetes was more frequent among mothers than fathers of probands (P = 0.02), but this maternal effect was not observed in second degree relatives. There are no significant differences in clinical and metabolic profiles between patients according to the transmission pattern of the disease. In conclusion, these results suggest familial aggregation and excess maternal transmission of type 2 diabetes in the Moroccan studied population.
authors: Laboratoire de Génétique Moléculaire et Humaine, Département de Recherche Scientifique, Institut Pasteur, 1 Place Louis Pasteur, 20360, Casablanca, Morocco. benrahmahouda@yahoo.fr
authors: Houda
authors: H
authors: Benrahma
authors: Imen
authors: I
authors: Arfa
authors: Majida
authors: M
authors: Charif
authors: Safaa
authors: S
authors: Bounaceur
authors: Abdelmajid
authors: A
authors: Eloualid
authors: Redouane
authors: R
authors: Boulouiz
authors: Halima
authors: H
authors: Nahili
authors: Omar
authors: O
authors: Abidi
authors: Hassan
authors: H
authors: Rouba
authors: Asmaa
authors: A
authors: Chadli
authors: Mounia
authors: M
authors: Oudghiri
authors: Ahmed
authors: A
authors: Farouqui
authors: Sonia
authors: S
authors: Abdelhak
authors: Abdelhamid
authors: A
authors: Barakat
mesh_terms: D017668:Age of Onset; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005190:Family; D005220:Fathers / Q000706:statistics & numerical data; D005260:Female; D018392:Genomic Imprinting; D006801:Humans; D008297:Male; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D009035:Mothers / Q000706:statistics & numerical data; D010375:Pedigree; D015995:Prevalence; D012737:Sex Factors