title: Outcome after surgical resection of isolated metastases to the pancreas.
abstract: OBJECTIVE
  The pancreas is an unusual site for metastases. Thus, the efficacy of pancreatic resection in patients with metastatic pancreas cancer remains unclear. This study examined the result of surgical resection for patients with pancreatic metastases.
  
  
  METHODS
  A retrospective analysis was undertaken of fifteen patients subjected to surgical resection of pancreatic metastases from January 1983 to September 2008.
  
  
  RESULTS
  The median disease-free interval between the primary and metastatic cancer was 59 months (range, 0-180 months). Median survival of the 15 patients was 31 months (95% CI, 26-35 months). The primary histopathology was renal cell carcinoma (RCC) (n=7, 47%), colorectal cancer (n=3), breast cancer (n=1), non-small-cell lung cancer (n=1), ovarian cancer (n=1), cervical cancer (n=l), or leiomyosarcoma (n=1). Surgical procedures included pancreaticoduodenectomy (n=6), distal pancreatectomy (n=8), and medial pancreatectomy followed by total pancreatectomy (n=1). Median survival after pancreatectomy was 45 months in patients with RCC and 31 months in those with non-RCC as primary cancer (p = 0.49).
  
  
  CONCLUSIONS
  Surgical resection is the treatment of choice for maximizing long-term survival in patients with pancreatic metastases from RCC. However, resection of pancreatic metastases from non-RCC patients carries a poor prognosis, and pancreatectomy is probably not warranted.
authors: Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo 135-8500, Japan.
authors: Yoshimasa
authors: Y
authors: Akashi
authors: Akio
authors: A
authors: Saiura
authors: Yoji
authors: Y
authors: Kishi
authors: Rontaro
authors: R
authors: Koga
authors: Ryo
authors: R
authors: Morimura
authors: Ryuji
authors: R
authors: Yoshioka
authors: Junji
authors: J
authors: Yamamoto
authors: Toshiharu
authors: T
authors: Yamaguchi
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome