title: [Radiation-induced fibrosarcomas rapidly appeared more than 20 years after radiation therapy for germ cell tumors: report of two cases].
abstract: Radiation-induced brain tumor is a rare but serious and potentially fatal complication. We report two cases of radiation-induced fibrosarcomas which occurred more than 20 years after whole brain radiation therapy (60 Gy) for intracranial germinomas. Although both of them underwent imaging examination every year, the symptomatic sarcomas developed rapidly within a year. Eight months after total removal, the tumor recurred in the one case. Second surgery and gamma knife surgery could not prevent the tumor progression. In the other case, tumor regrowth was not observed during the five months follow-up after total removal surgery. It is important to keep in mind the possibility of a postradiation sarcoma that might have developed very aggressively after a long latent period.
authors: Department of Neurosurgery, Tokyo Rosai Hospital.
authors: Koichi
authors: K
authors: Kato
authors: Ai
authors: A
authors: Namioka
authors: Masanori
authors: M
authors: Nakagawa
authors: Shigeru
authors: S
authors: Kadoyama
authors: Naohisa
authors: N
authors: Kaneko
authors: Hiroshi
authors: H
authors: Kiduki
authors: Hiroshi
authors: H
authors: Ujiie
authors: Kazuhiro
authors: K
authors: Nomura
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D002648:Child; D005354:Fibrosarcoma / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced / Q000473:pathology / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects; D013997:Time Factors