title: The cyclooxygenase-1 C50T polymorphism is not associated with aspirin responsiveness status in stable coronary artery disease in Tunisian patients.
abstract: In this study, we evaluate the relationships between aspirin nonresponsiveness and the cyclooxygenase-1 (Cox-1) gene C50T polymorphism in stable coronary artery disease (CAD) in Tunisian patients. One hundred twenty-five stable CAD patients were included. The Cox-1 gene C50T polymorphism was determined by the polymerase chain reaction/restriction fragment length polymorphism method. Aspirin response was evaluated by measuring the collagen epinephrine closer time and the urinary dehydro-thromboxane B2 excretion. According to the collagen epinephrine closer time values, the frequency of the -50T allele was not significantly different in bad responders when compared with good responders (36.8% vs. 15.7%; p=0.1). Similarly, the presence of the -50T mutant allele was not statistically different comparing bad and good responders according to the urinary 11-dehydro-thromboxane B2 excretion concentration (60% vs. 40%; p=0.43). Our study did not demonstrate any association between the Cox-1 gene C50T polymorphism and aspirin nonresponsiveness status in stable CAD patients.
authors: Regional Center of Blood Transfusion, Research Unit Platelet function Study UR.06SP05, Farhat Hached University Hospital, Sousse, Tunisia. chakrount@voila.fr
authors: Tahar
authors: T
authors: Chakroun
authors: Faouzi
authors: F
authors: Addad
authors: Saloua
authors: S
authors: Yacoub
authors: Fatma
authors: F
authors: Abderrezak
authors: Gregoris T
authors: GT
authors: Gerotziafas
authors: Sadia
authors: S
authors: Abdelkafi
authors: Mohssen
authors: M
authors: Hassine
authors: Habib
authors: H
authors: Gamra
authors: Mohamed
authors: M
authors: Hatmi
authors: Ismail
authors: I
authors: Elalamy
mesh_terms: D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects*; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000235:genetics; D051545:Cyclooxygenase 1 / Q000235:genetics*; D004351:Drug Resistance; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D013929:Thromboxane B2 / Q000031:analogs & derivatives / Q000652:urine; D014416:Tunisia
chemical_list: D013929:Thromboxane B2; C049235:11-dehydro-thromboxane B2; D051545:Cyclooxygenase 1; D001241:Aspirin