title: High prevalence of low bone mineral density in patients with tropical calcific pancreatitis.
abstract: OBJECTIVE
  Patients with tropical calcific pancreatitis (TCP) have multiple risk factors for developing low bone mineral density (BMD). We studied BMD and serum 25-hydroxyvitamin D (25[OH]D) in north Indian TCP patients.
  
  
  METHODS
  In a cross-sectional study, 72 TCP patients (mean age, 31 ± 10 years) and 100 controls were studied. Serum 25(OH)D was measured in all subjects; BMD was measured by dual-energy x-ray absorptiometry in 56 adult patients and 4 children and compared with a reference Indian population.
  
  
  RESULTS
  Mean BMD and BMD Z-scores at the lumbar spine and total hip were significantly lower in all age groups. The BMD Z-scores at the lumbar spine and total hip were -1.0 ± 1.0 and -1.2 ± 1.2, respectively. Low bone density (Z-score ≤ -2 at ≥ 1 sites) was present in 22 (39%) adult patients and 3 of the 4 children studied. On multivariate analysis, BMD Z-scores were positively associated with body mass index and inversely with pancreatitis. Vitamin D deficiency (25[OH]D < 50 nmol/L) was equally prevalent in patients (86%) and controls (85%).
  
  
  CONCLUSIONS
  Despite their young age, patients with TCP have significantly low BMD. Measures to improve nutrition should be instituted in all TCP patients from an early age.
authors: Departments of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors: Akhil
authors: A
authors: Joshi
authors: Sagili Vijaya Bhaskar
authors: SV
authors: Reddy
authors: Vijayalakshmi
authors: V
authors: Bhatia
authors: Gourdas
authors: G
authors: Choudhuri
authors: Rajneesh K
authors: RK
authors: Singh
authors: Nirupama
authors: N
authors: Singh
authors: Eesh
authors: E
authors: Bhatia
mesh_terms: D000293:Adolescent; D000328:Adult; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications / Q000378:metabolism; D002112:Calcifediol / Q000097:blood; D002114:Calcinosis / Q000150:complications / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D015999:Multivariate Analysis; D050500:Pancreatitis, Chronic / Q000150:complications / Q000378:metabolism*; D014329:Tropical Climate; D014808:Vitamin D Deficiency / Q000150:complications / Q000378:metabolism; D055815:Young Adult
chemical_list: D002112:Calcifediol