title: Small bowel metastasis from lung cancer: a possible cause of acute abdomen. Case report and literature review.
abstract: OBJECTIVE
  Lung cancer represents the leading cause of tumor death in the world with 50% of patients presenting metastatic disease at the time of diagnosis. Gastrointestinal (GI) lung cancer metastasis were thought to be extremely rare, but a much higher incidence has been noted in several autoptic reports. Clinical relevance of GI metastasis is low, but can increase with the higher number of newly diagnosed patients and with the efficacy of systemic chemotherapy in advanced stages. Prognosis of complicated GI lung cancer metastasis seems to be worse than the natural course of the disease and acute bleeding or perforation of metastatic site can be accelerated by chemotherapy.
  
  
  METHODS
  We describe the clinical case of a patient presenting with acute abdomen due to small bowel perforation from GI lung cancer metastasis. A review of the most recent published literature on GI lung cancer metastasis was performed.
  
  
  CONCLUSIONS
  GI metastasis from lung cancer may occur within the clinical course of the disease and require surgical treatment followed by a poor outcome. Percentage of lung cancer patients with GI metastasis can reach level of 14%. Large cells carcinomas causing kidney and adrenal metastasis are more likely associated with GI localization of the disease.
  
  
  CONCLUSIONS
  Complications of GI metastases, although rare, must be considered as possible cause of acute abdomen in patients with lung cancer. Identification of clinical indicators of GI metastasis may help in the therapeutic strategy.
authors: School of Medicine, University of Perugia, Italy.
authors: W
authors: W
authors: Bugiantella
authors: E
authors: E
authors: Cavazzoni
authors: L
authors: L
authors: Graziosi
authors: S
authors: S
authors: Valiani
authors: M S
authors: MS
authors: Franceschini
authors: A
authors: A
authors: Donini
mesh_terms: D000006:Abdomen, Acute / Q000209:etiology*; D000368:Aged; D018287:Carcinoma, Large Cell / Q000150:complications* / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D007580:Jejunal Neoplasms / Q000150:complications* / Q000556:secondary*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male