title: Anti-inflammatory, laxative and intestinal motility effects of Senna macranthera leaves.
abstract: Several species of Senna are well known for their therapeutic properties, being used in folk medicine to treat throat inflammation and constipation. In this regard, the anti-inflammatory, laxative and intestinal motility effects of different extracts of Senna macranthera (Colladon) H. Irwin and Barneby leaves were determined. The hexane extract significantly reduced carrageenan-induced paw oedema in rats in a manner similar to that of sodium diclofenac. A laxative effect was observed for the methanolic and hexane extracts comparative to the standard drug bisacodyl; however, only the hexane extract increased the intestinal motility in the studied period. Moreover, the extracts were evaluated for their antioxidant activity and the ethyl acetate extract presented a pronounced activity comparable to the standard rutin. Phytochemical screening was also performed and phenolic compounds like flavonoids, tannins and coumarins were observed in all extracts except for the hexane extract, which instead presented anthrones, triterpenes and steroids in its composition. The HPLC profile showed the presence of the anthraquinone emodine in all tested extracts.
authors: Departamento de Bioquímica, ICB, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.
authors: Lyvia
authors: L
authors: Guarize
authors: Juliana C da
authors: JC
authors: Costa
authors: Leandro B
authors: LB
authors: Dutra
authors: Renata F
authors: RF
authors: Mendes
authors: Isabel V A
authors: IV
authors: Lima
authors: Elita
authors: E
authors: Scio
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D002351:Carrageenan / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000302:isolation & purification; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D005769:Gastrointestinal Motility / Q000187:drug effects*; D054368:Laxatives / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D029846:Senna Plant / Q000737:chemistry*; D013634:Tannins / Q000302:isolation & purification
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D003374:Coumarins; D005419:Flavonoids; D054368:Laxatives; D010936:Plant Extracts; D013634:Tannins; D002351:Carrageenan