title: Bistability and oscillations in gene regulation mediated by small noncoding RNAs.
abstract: The interplay of small noncoding RNAs (sRNAs), mRNAs, and proteins has been shown to play crucial roles in almost all cellular processes. As key post-transcriptional regulators of gene expression, the mechanisms and roles of sRNAs in various cellular processes still need to be fully understood. When participating in cellular processes, sRNAs mainly mediate mRNA degradation or translational repression. Here, we show how the dynamics of two minimal architectures is drastically affected by these two mechanisms. A comparison is also given to reveal the implication of the fundamental differences. This study may help us to analyze complex networks assembled by simple modules more easily. A better knowledge of the sRNA-mediated motifs is also of interest for bio-engineering and artificial control.
authors: Institute of Systems Biology, Shanghai University, Shanghai, China.
authors: Dengyu
authors: D
authors: Liu
authors: Xiao
authors: X
authors: Chang
authors: Zengrong
authors: Z
authors: Liu
authors: Luonan
authors: L
authors: Chen
authors: Ruiqi
authors: R
authors: Wang
mesh_terms: D005786:Gene Expression Regulation; D008957:Models, Genetic; D017711:Nonlinear Dynamics; D058727:RNA, Small Untranslated / Q000235:genetics* / Q000378:metabolism
chemical_list: D058727:RNA, Small Untranslated