title: [Histological findings in an irradiated choroidal melanoma].
abstract: BACKGROUND
  Histological findings of choroidal melanomas after proton beam irradiation have been reported for complicated cases after enucleation. We present specimens of a tumor after transretinal probe excision.
  
  
  METHODS
  One year after irradiation, the biopsy was examined histologically.
  
  
  RESULTS
  The specimens showed pigmented, spindle-shaped cells staining positively for Melan-A and HMB-45. Ki-67 showed low proliferation. Caspase-3 staining was normal.
  
  
  CONCLUSIONS
  The melanoma still contained vital and even single proliferating cells, but regressed afterwards without additional therapy.
authors: Klinik für Ophthalmologie, UK-SH Campus Kiel, Arnold-Heller-Strasse 3, Kiel, Germany. koinzer@auge.uni-kiel.de
authors: S
authors: S
authors: Koinzer
authors: H
authors: H
authors: Hasselbach
authors: J H
authors: JH
authors: Bräsen
authors: I
authors: I
authors: Leuschner
authors: J
authors: J
authors: Roider
mesh_terms: D001706:Biopsy; D049109:Cell Proliferation; D002470:Cell Survival / Q000528:radiation effects*; D002829:Choroid / Q000473:pathology / Q000528:radiation effects; D002830:Choroid Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology / Q000532:radiotherapy; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000532:radiotherapy; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000532:radiotherapy; D019721:Ophthalmoscopes