title: Measurements of Radiation-Induced Skin Changes in Breast-Cancer Radiation Therapy Using Ultrasonic Imaging.
abstract: Skin injury is a common side effect of breast-cancer radiation therapy. Although physicians often observe skin toxicity, quantifying its severity remains a challenge. We present a novel quantitative ultrasonic technique to evaluate skin changes associated with radiotherapy. An in vivo study with twelve breast-cancer patients was conducted. All patients received a standard course of post-surgery radiation therapy. Each patient received ultrasound scans to the irradiated breast and the untreated (contra-lateral) breast. Radio-frequency (RF) backscatter signals and B-mode images were acquired simultaneously. To quantify the severity of skin injury, two metrics were calculated from the RF signals: skin thickness and Pearson correlation coefficient of the subcutaneous layer. Comparing to the non-irradiated skin, the average thickness of the irradiated skin increased by 40% (p=0.005) and the average correlation coefficient of the irradiated hypodermis decreased by 35% (p=0.02). This study demonstrates the feasibility of using a non-invasive ultrasonic technique to detect and quantify radiation-induced skin changes.
authors: Columbia University Medical Center, New York, NY.
authors: Tian
authors: T
authors: Liu
authors: Jun
authors: J
authors: Zhou
authors: K Sunshine
authors: KS
authors: Osterman
authors: Pengpeng
authors: P
authors: Zhang
authors: Shermian A
authors: SA
authors: Woodhouse
authors: Peter B
authors: PB
authors: Schiff
authors: Gerald J
authors: GJ
authors: Kutcher