title: Magnesium sulfate and sodium valproate block methylphenidate-induced hyperlocomotion, an animal model of mania.
abstract: Magnesium sulfate (MgSO4) is used to treat and prevent eclamptic seizures, and several anticonvulsant drugs (e.g., sodium valproate) are clinically effective antimanic drugs. Psychostimulant-induced hyperlocomotion has been proposed as an animal model for the study of antimanic drugs. The present study evaluated the effects of MgSO4 and sodium valproate (as a positive control) on hyperlocomotion induced by methylphenidate in mice. Acute MgSO4 (300-400 mg/kg), but not sodium valproate (100-300 mg/kg), prevented the increase in locomotor activity induced by methylphenidate (5.0 mg/kg). In contrast, repeated treatment (14 days) with valproate (300 mg/kg), but not MgSO4 (400 mg/kg), blocked methylphenidate-induced hyperlocomotion. Thus, acute MgSO4 exerted antimanic-like effects in this animal model.
authors: Department of Pharmacology, Division of Biological Sciences, Universidade Federal do Paraná, Centro Politécnico C.P. 19031, Curitiba, PR, 81540-990 Brazil.
authors: Francisco J
authors: FJ
authors: Barbosa
authors: Bernardete
authors: B
authors: Hesse
authors: Rodrigo B
authors: RB
authors: de Almeida
authors: Irinéia P
authors: IP
authors: Baretta
authors: Roseli
authors: R
authors: Boerngen-Lacerda
authors: Roberto
authors: R
authors: Andreatini
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology; D018692:Antimanic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D014635:Valproic Acid / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D018692:Antimanic Agents; D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D014635:Valproic Acid; D008278:Magnesium Sulfate