title: Efficacy of antiamebic drugs in a mouse model.
abstract: Nitroimidazole antibiotics are the mainstay of treatment of invasive amebiasis; however, few comparative studies of applicable antibiotics are available. Evidence of sporadic clinical failure and rare reports of metronidazole resistance have led to the investigation of novel antiamebic therapeutics. The goal of this study was to examine drug efficacy in both in vitro and in vivo models of intestinal amebiasis. We studied six current and three novel drugs. Many drugs, including metronidazole, nitazoxanide, and nitazoxanide derivatives, were shown to be potently inhibitory in vitro. However, metronidazole remained the most effective in vivo, both in preventative and curative regimens, underscoring the value of animal models in evaluating future therapies.
authors: Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, 345 Crispell Drive, Charlottesville, VA 22908, USA. smb7yv@virginia.edu
authors: Stephen
authors: S
authors: Becker
authors: Paul
authors: P
authors: Hoffman
authors: Eric R
authors: ER
authors: Houpt
mesh_terms: D000562:Amebiasis / Q000188:drug therapy*; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009593:Nitroimidazoles / Q000627:therapeutic use*
chemical_list: D000981:Antiprotozoal Agents; D009593:Nitroimidazoles