title: [Correlation between single nucleotide polymorphism and periodontitis susceptibility in Shanghai Chinese patients].
abstract: OBJECTIVE
  To investigate the correlation between 12 single nucleotide polymorphisms (SNPs) from 7 genes and periodontitis of susceptibility in Shanghai Chinese patients.
  
  
  METHODS
  Genotypes of randomly grouped 50 health control subjects and 48 patients with chronic periodontitis were genotyped by MALDI-TOF MS detection system. A questionnaire, medical history, family history, signs, laboratory tests, treatment, follow-up information were collected. Statistical analysis of Chi-square test was performed using SPSS13.0 software package.
  
  
  RESULTS
  In the screening of the 12 target SNPs,the GG genotype of rs2891168 correlated significantly with periodontitis, OR=3.071(95%CI:1.018-9.260,P=0.046).
  
  
  CONCLUSIONS
  The GG genotype of rs2891168 may correlate significantly with periodontitis of Shanghai Chinese patients and further studies are needed to verify this finding. Supported by Natural Science Foundation of Shanghai Municipality (Grant No.10ZR1425900) and Research Fund of Bureau of Health of Shanghai Municipality (Grant No.2009202).
authors: Department of Oral Medicine,Shanghai Stomatological Disease Center. Shanghai 200031,China. chendong19690124@sohu.com
authors: Dong
authors: D
authors: Chen
authors: Kun
authors: K
authors: Feng
authors: Li-Ming
authors: LM
authors: Wang
authors: Tian-Liang
authors: TL
authors: Zhang
authors: Can
authors: C
authors: Zeng
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D002681:China; D055113:Chronic Periodontitis; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide