title: Reproductive toxicity in male mice exposed to Nanjing City tap water.
abstract: End points of reproductive toxicity were investigated in male mice (Mus musculus, ICR) fed Nanjing City tap water for 90 days. There was no significant alteration in body weights between treatment and control mice. In treated mice, flow cytometry analysis of testicular tissue indicated that the relative percentage of the elongated spermatid (HC) decreased significantly (P < 0.05). Also slight increases in the relative percentage of round spermatids (1C) and primary spermatocytes (4C) were noted. The ratios of 4C:2C (diploid germ cells) and 1C:2C increased, and testicular histopathology indicated an expansion of interstitial space and a decreased number and size of Leydig cells in treated mice. The current study suggests that Nanjing City tap water is toxic to the reproductive system of mice and additional study to evaluate its effects on other species, including human beings, would be warranted.
authors: State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, College of Hydrology and Water Resources, Hohai University, Nanjing, 210098, People's Republic of China. dyzhao@hhu.edu.cn
authors: Dayong
authors: D
authors: Zhao
authors: Yajun
authors: Y
authors: Chen
authors: Kemei
authors: K
authors: Zhou
authors: Shupei
authors: S
authors: Cheng
authors: Ting
authors: T
authors: Ma
authors: Cuiling
authors: C
authors: Jiang
authors: Wenming
authors: W
authors: Yan
authors: Liqin
authors: L
authors: Zhu
authors: Xijun
authors: X
authors: Gu
authors: Xiaohua
authors: X
authors: Zhu
authors: Bing
authors: B
authors: Wu
authors: Yan
authors: Y
authors: Zhang
authors: Xuxiang
authors: X
authors: Zhang
mesh_terms: D000818:Animals; D002681:China; D002947:Cities; D004784:Environmental Monitoring; D008297:Male; D051379:Mice; D009930:Organic Chemicals / Q000633:toxicity; D012098:Reproduction / Q000187:drug effects*; D018570:Risk Assessment; D013090:Spermatocytes / Q000187:drug effects / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014881:Water Supply / Q000032:analysis*
chemical_list: D009930:Organic Chemicals; D014874:Water Pollutants, Chemical