title: Wnt signaling and orthopedics, an overview.
abstract: Wnt signaling is a ubiquitous system for intercellular communication, with multiple functions during development and in homeostasis of the body. It comprises several ligands, receptors, and inhibitors. Some molecules, such as sclerostin, appear to have bone-specific functions, and can be targeted by potential drugs. Now, ongoing clinical trials are testing these drugs as treatments for osteoporosis. Animal studies have also suggested that these drugs can accelerate fracture healing and implant fixation. This brief overview focuses on currently available information on the effects of manipulations of Wnt signaling on bone healing.
authors: Department of Clinical and Experimental Medicine, IKE, Faculty of Health Sciences, Linköping University, Linköping, Sweden. fredrik.agholme@liu.se
authors: Fredrik
authors: F
authors: Agholme
authors: Per
authors: P
authors: Aspenberg
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000502:physiology; D005500:Follow-Up Studies; D017102:Fracture Healing / Q000502:physiology; D006801:Humans; D010012:Osteogenesis / Q000502:physiology; D010024:Osteoporosis / Q000188:drug therapy; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism / Q000502:physiology*
chemical_list: D019485:Bone Morphogenetic Proteins; D051153:Wnt Proteins