title: The impact of change in visual field on health-related quality of life the los angeles latino eye study.
abstract: OBJECTIVE
  To assess the impact of change in visual field (VF) on change in health-related quality of life (HRQoL) at the population level.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Three thousand one hundred seventy-five Los Angles Latino Eye Study participants.
  
  
  METHODS
  Objective measures of VF and visual acuity and self-reported HRQoL were collected at baseline and at the 4-year follow-up. Analysis of covariance was used to evaluate mean differences in change of HRQoL across severity levels of change in VF and to test for effect modification by covariates.
  
  
  METHODS
  General and vision-specific HRQoL.
  
  
  RESULTS
  Of 3175 participants, 1430 (45%) showed a change in VF (≥1 decibel [dB]) and 1715 (54%) reported a clinically important change (≥5 points) in vision-specific HRQoL. Progressive worsening and improvement in the VF were associated with increasing losses and gains in vision-specific HRQoL for the composite score and 10 of its 11 subscales (all P(trend)<0.05). Losses in VF of more than 5 dB and gains of more than 3 dB were associated with clinically meaningful losses and gains in vision-specific HRQoL, respectively. Areas of vision-specific HRQoL most affected by greater losses in VF were driving, dependency, role-functioning, and mental health. The effect of change in VF (loss or gain) on mean change in vision-specific HRQoL varied by level of baseline vision loss (in VF, visual acuity, or both) and by change in visual acuity (all P(interaction)<0.05). Those with moderate or severe VF loss at baseline and with a more than 5 dB loss in VF during the study period had a mean loss of vision-specific HRQoL of 11.3 points, whereas those with no VF loss at baseline had a mean loss of 0.97 points. Similarly, with a more than 5 dB loss in VF and baseline visual acuity impairment (mild or severe), there was a loss in vision-specific HRQoL of 10.5 points, whereas with no visual acuity impairment at baseline, there was a loss of vision-specific HRQoL of 3.7 points.
  
  
  CONCLUSIONS
  Both losses and gains in VF produce clinically meaningful changes in vision-specific HRQoL. In the presence of pre-existing vision loss (VF and visual acuity), similar levels of VF change produce greater losses in QOL.
authors: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors: Cecilia M
authors: CM
authors: Patino
authors: Rohit
authors: R
authors: Varma
authors: Stanley P
authors: SP
authors: Azen
authors: David V
authors: DV
authors: Conti
authors: Michael B
authors: MB
authors: Nichol
authors: Roberta
authors: R
authors: McKean-Cowdin
mesh_terms: D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006630:Hispanic or Latino; D006801:Humans; D015141:Los Angeles / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D012720:Severity of Illness Index; D014786:Vision Disorders / Q000208:ethnology / Q000503:physiopathology* / Q000523:psychology*; D014792:Visual Acuity; D014794:Visual Fields