title: Sporadic desmoid tumors of the chest: long-term follow-up of 28 multimodally treated patients.
abstract: BACKGROUND
  Desmoids of the chest are extremely rare borderline tumors. Radical surgical resection is considered to be the primary treatment. Achieving negative margins is often a challenge. Cases with positive surgical margins are associated with high risk of local recurrence.
  
  
  METHODS
  A retrospective multicenter review was undertaken of 28 patients who underwent surgery for sporadically appearing desmoids of the chest between 1988 and 2008. Clinico-pathological data were investigated in detail. Authors have statistically analyzed the relationships between gender, age, tumor size, radicality of the first surgery, impact of the pharmacologic treatment, estrogen receptor positivity, and the development of local recurrences after a median follow-up period of 104 months.
  
  
  RESULTS
  Primary surgery was radical in 14 patients (50%). Mean pathologic diameter was 72.14mm. Wide surgical excision was performed in 27 primary cases, out of which 10 cases (37%) were full- and 17 cases (63%) partial-thickness chest wall resections. Synthetic mesh stabilization was used in nine cases and soft tissue coverage in six patients. Morbidity rate was 25%. Recurrences were found in 63% of the cases, with a mean time of 30.5 months to first recurrences. Our investigation confirmed that microscopically free surgical margin of the first tumor resection significantly affected local tumor control.
  
  
  CONCLUSIONS
  Because the radicality of the first surgical resection is of essential importance for long-time local control of chest desmoids, accurate preoperative diagnostics and well-planned aggressive surgical resection of the primary tumor is recommended. Due to the low incidence of desmoids, multicentric randomized investigations would be mandatory to establish evidence-based protocol for desmoid tumors.
authors: Department of General and Thoracic Surgery, Laser and Reconstructive Plastic Surgery, National Institute of Oncology, Budapest, Hungary. matraidok@freemail.hu
authors: Zoltán
authors: Z
authors: Mátrai
authors: László
authors: L
authors: Tóth
authors: Zoltán
authors: Z
authors: Szentirmay
authors: Ferenc Rényi
authors: FR
authors: Vámos
authors: Walter
authors: W
authors: Klepetko
authors: Pál
authors: P
authors: Vadász
authors: István
authors: I
authors: Kenessey
authors: Miklós
authors: M
authors: Kásler
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D003131:Combined Modality Therapy; D004812:Epidemiologic Methods; D005260:Female; D018222:Desmoid Tumors / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual; D011183:Postoperative Complications; D011960:Receptors, Estrogen / Q000032:analysis; D019651:Plastic Surgery Procedures / Q000379:methods; D013524:Surgical Flaps; D013899:Thoracic Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen