title: Effects of ethyl alcohol administration to rat dams during the gestation period on learning behavior and on levels of monoamines and metabolites in rat pup brain after birth.
abstract: Pregnant rats were given 0%-, 5%-, 10%- and 20% ethyl alcohol in drinking water during the gestation period.We evaluated the brain function of pups born of alcohol-administered dams. Learning ability (Sidman avoidance behavior), the amounts of monoamines (noradrenalin, dopamine, serotonin) and metabolites (3,4-dihydroxyphenyl acetic acid [DOPAC], homovanillic acid [HVA] and 5-hydroxyindole acetic acid [5-HIAA])in whole brain were examined for neurobehavioral and neurochemical effects.There was no effect on Sidman avoidance behavior in 56-day-old offspring, but alterations of the amounts of monoamines and their metabolites were observed even in 66-day-old offspring as a result of the dams' exposure to ethanol during pregnancy.
authors: Division of Community and Environmental Health, Department of Environmental Health, Tokai University School of Medicine, 259-11, Bohseidai, Isehara, Kanagawa, Japan.
authors: H
authors: H
authors: Furuya
authors: H
authors: H
authors: Aikawa
authors: T
authors: T
authors: Yoshida
authors: I
authors: I
authors: Okazaki