title: Surface-based TBM boosts power to detect disease effects on the brain: an N=804 ADNI study.
abstract: Computational anatomy methods are now widely used in clinical neuroimaging to map the profile of disease effects on the brain and its clinical correlates. In Alzheimer's disease (AD), many research groups have modeled localized changes in hippocampal and lateral ventricular surfaces, to provide candidate biomarkers of disease progression for drug trials. We combined the power of parametric surface modeling and tensor-based morphometry to study hippocampal differences associated with AD and mild cognitive impairment (MCI) in 490 subjects (97 AD, 245 MCI, 148 controls) and ventricular differences in 804 subjects scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI; 184 AD, 391 MCI, 229 controls). We aimed to show that a new multivariate surface statistic based on multivariate tensor-based morphometry (mTBM) and radial distance provides a more powerful way to detect localized anatomical differences than conventional surface-based analysis. In our experiments, we studied correlations between hippocampal atrophy and ventricular enlargement and clinical measures and cerebrospinal fluid biomarkers. The new multivariate statistics gave better effect sizes for detecting morphometric differences, relative to other statistics including radial distance, analysis of the surface tensor and the Jacobian determinant. In empirical tests using false discovery rate curves, smaller sample sizes were needed to detect associations with diagnosis. The analysis pipeline is generic and automated. It may be applied to analyze other brain subcortical structures including the caudate nucleus and putamen. This publically available software may boost power for morphometric studies of subcortical structures in the brain.
authors: School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ 85281, USA. ylwang@asu.edu
authors: Yalin
authors: Y
authors: Wang
authors: Yang
authors: Y
authors: Song
authors: Priya
authors: P
authors: Rajagopalan
authors: Tuo
authors: T
authors: An
authors: Krystal
authors: K
authors: Liu
authors: Yi-Yu
authors: YY
authors: Chou
authors: Boris
authors: B
authors: Gutman
authors: Arthur W
authors: AW
authors: Toga
authors: Paul M
authors: PM
authors: Thompson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003072:Cognition Disorders / Q000134:cerebrospinal fluid / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015999:Multivariate Analysis; D012984:Software; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D016875:tau Proteins