title: A Monte Carlo analysis of peritoneal antimicrobial pharmacokinetics.
abstract: Peritoneal dialysis-associated peritonitis (PDAP) can be treated using very different regimens of antimicrobial administration, regimens that result in different pharmacokinetic outcomes and systemic exposure levels. Currently, there is no population-level pharmacokinetic framework germane to the treatment of PDAP. We coupled a differential-equation-based model of antimicrobial kinetics to a Monte Carlo simulation framework, and conducted "in silico" clinical trials to explore the anticipated effects of different antimicrobial dosing regimens on relevant pharmacokinetic parameters (AUC/MIC and time greater than 5 ×MIC) and the level of systemic exposure.
authors: Department of Mathematics, Fisk University, Nashville, TN 37208, USA. sanjuktahota@gmail.com
authors: Sanjukta
authors: S
authors: Hota
authors: Philip
authors: P
authors: Crooke
authors: John
authors: J
authors: Hotchkiss
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001202:Ascitic Fluid / Q000378:metabolism; D002437:Cefazolin / Q000008:administration & dosage / Q000493:pharmacokinetics; D002442:Ceftazidime / Q000008:administration & dosage / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D019295:Computational Biology; D003198:Computer Simulation; D015314:Dialysis Solutions; D006801:Humans; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D009010:Monte Carlo Method; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D000890:Anti-Infective Agents; D015314:Dialysis Solutions; D002442:Ceftazidime; D002437:Cefazolin