title: Spindle disturbances in human-hamster hybrid (A(L) ) cells induced by the electrical component of the mobile communication frequency range signal.
abstract: The production of spindle disturbances in a human-hamster hybrid (A(L) ) cell line by an electromagnetic field (EMF) with field strength of 90 V/m at a frequency of 900 MHz was studied in greater detail. The experimental setup presented allows investigating whether either the electrical (E) and/or the magnetic (H) field component of EMF can be associated with the effectiveness of the spindle-disturbing potential. Therefore, both field components of a transversal electromagnetic field (TEM) wave have been separated during exposure of the biological system. This procedure should give more insight on understanding the underlying mechanisms of non-thermal effects of EMF. A statistical comparison of the proportions of the fractions of ana- and telophases with spindle disturbances, obtained for five different exposure conditions with respect to unexposed controls (sham condition), showed that only cells exposed to the H-field component of the EMF were not different from the control. Therefore, the results of the present study indicate that an exposure of cells to EMF at E-field strengths of 45 and 90 V/m, as well as to the separated E component of the EMF, induces significant spindle disturbances in ana- and telophases of the cell cycle.
authors: Physikalisch-Technische Bundesanstalt (PTB), Department 2.2: High Frequency and Electromagnetic Fields, Braunschweig, Germany. thorsten.schrader@ptb.de
authors: Thorsten
authors: T
authors: Schrader
authors: Thomas
authors: T
authors: Kleine-Ostmann
authors: Klaus
authors: K
authors: Münter
authors: Christian
authors: C
authors: Jastrow
authors: Ernst
authors: E
authors: Schmid
mesh_terms: D000705:Anaphase / Q000528:radiation effects; D000818:Animals; D002460:Cell Line; D040421:Cell Phone; D006224:Cricetinae; D004560:Electricity / Q000009:adverse effects*; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology* / Q000473:pathology / Q000528:radiation effects*; D008280:Magnetics; D011846:Radio Waves / Q000009:adverse effects*; D013692:Telophase / Q000528:radiation effects