title: Key role of microRNAs in Waldenström's macroglobulinemia pathogenesis.
abstract: Epigenetics represent heritable changes in gene expression that are not due to any alteration in the DNA sequence. One of the best-known epigenetic markers is histone acetylation, which has been shown to be deregulated in neoplastic diseases, including B-cell malignancies, such as Waldenström's Macroglobulinemia (WM), a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a serum monoclonal immunoglobulin M in the circulation. It has been recently demonstrated that microRNAs may be responsible for modulating histone acetylation in WM cells, thus providing the preclinical evidences for using microRNA-based therapeutic strategies in this disease.
authors: Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
authors: Antonio
authors: A
authors: Sacco
authors: Patricia
authors: P
authors: Maiso
authors: Abdelkareem
authors: A
authors: Azab
authors: Feda
authors: F
authors: Azab
authors: Yong
authors: Y
authors: Zhang
authors: Yang
authors: Y
authors: Liu
authors: Hai T
authors: HT
authors: Ngo
authors: Brittany
authors: B
authors: Morgan
authors: Phong
authors: P
authors: Quang
authors: Ghayas
authors: G
authors: Issa
authors: Irene M
authors: IM
authors: Ghobrial
authors: Aldo M
authors: AM
authors: Roccaro
mesh_terms: D057890:Epigenomics; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics* / Q000473:pathology
chemical_list: D035683:MicroRNAs