title: Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome.
abstract: Streptococcal toxic shock syndrome (STSS) is characterized by diffuse vascular leak resulting from widespread endothelial activation. Angiopoietin-1 and -2 (Ang-1 and Ang-2), which are important regulators of endothelial quiescence and activation, respectively, are dysregulated in certain diseases that are associated with endothelial dysfunction, but they have not been previously investigated in STSS. Plasma Ang-1 and Ang-2 concentrations were measured in 37 patients with invasive streptococcal infection with and without concurrent STSS. Greater angiopoietin dysregulation (decreased Ang-1 and increased Ang-2) occurred in STSS than in invasive infection without shock; dysregulation decreased with convalescence. These results suggest that systemic Ang-1 and Ang-2 dysregulation is associated with disease severity in invasive streptococcal infection and that plasma levels of Ang-1 and Ang-2 may serve as clinically informative biomarkers in STSS.
authors: Division of Infectious Diseases, SA Rotman Laboratories, McLaughlin-Rotman Centre for Global Health, Toronto General Hospital-University Health Network, Toronto, Ontario, Canada.
authors: Andrea V
authors: AV
authors: Page
authors: Malak
authors: M
authors: Kotb
authors: Allison
authors: A
authors: McGeer
authors: Donald E
authors: DE
authors: Low
authors: Kevin C
authors: KC
authors: Kain
authors: W Conrad
authors: WC
authors: Liles
mesh_terms: D042683:Angiopoietin-1 / Q000097:blood*; D042702:Angiopoietin-2 / Q000097:blood*; D015415:Biomarkers; D006801:Humans; D010949:Plasma / Q000737:chemistry; D012772:Shock, Septic / Q000175:diagnosis* / Q000473:pathology*; D013290:Streptococcal Infections / Q000175:diagnosis* / Q000473:pathology*
chemical_list: C467630:ANGPT1 protein, human; D042683:Angiopoietin-1; D042702:Angiopoietin-2; D015415:Biomarkers