title: Cytotoxic metabolites from the soil-derived fungus Exophiala pisciphila.
abstract: A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 3-4 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 1-4 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher's method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines.
authors: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Cui-Cui
authors: CC
authors: Wang
authors: Hai-Zhou
authors: HZ
authors: Liu
authors: Ming
authors: M
authors: Liu
authors: Yu-Yan
authors: YY
authors: Zhang
authors: Tian-Tian
authors: TT
authors: Li
authors: Xiu-Kun
authors: XK
authors: Lin
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D002850:Chromatography, Gel; D004354:Drug Screening Assays, Antitumor; D005093:Exophiala / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012988:Soil Microbiology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000970:Antineoplastic Agents