title: Synthesis of a combinatorial library of amides and its evaluation against the fall armyworm, Spodoptera frugiperda.
abstract: The fall armyworm Spodoptera frugiperda is a polyphagous pest that causes important damage in different regions of America and mainly affects corn crops in both tropical and subtropical areas. Currently, control relies on both transgenic plants and/or chemical pesticides. In this work we describe the preparation of an indexed combinatorial library of amides and its toxic effect by contact against S. frugiperda . (E)-1-(1-Piperidinyl)-3-[4-(trifluoromethoxy)phenyl]-2-propen-1-one was the most active compound with an LD(50) = 0.793 μg mg(-1) of larva. This amide was also evaluated by ingestion and at the lowest concentration (1 mg kg(-1)) achieved 83.3% mortality.
authors: Departament of Chemistry, Federal University of São Carlos, São Carlos, SP, Brazil.
authors: Thais C
authors: TC
authors: Castral
authors: Andreia P
authors: AP
authors: Matos
authors: Julia L
authors: JL
authors: Monteiro
authors: Fernanda M
authors: FM
authors: Araujo
authors: Tatiani M
authors: TM
authors: Bondancia
authors: Luciane G
authors: LG
authors: Batista-Pereira
authors: João B
authors: JB
authors: Fernandes
authors: Paulo C
authors: PC
authors: Vieira
authors: M Fatima G F
authors: MF
authors: da Silva
authors: Arlene G
authors: AG
authors: Corrêa
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D007306:Insecticides / Q000138:chemical synthesis* / Q000494:pharmacology; D018411:Spodoptera / Q000187:drug effects*
chemical_list: D000577:Amides; D007306:Insecticides