title: The association between first trimester micronutrient intake, MTHFR genotypes, and global DNA methylation in pregnant women.
abstract: OBJECTIVE
  Our aim was to evaluate possible associations between consumption of micronutrients involved in one-carbon metabolism, MTHFR genotypes, and global DNA methylation in pregnant women.
  
  
  METHODS
  A semi-quantitative dietary questionnaire was administered to 195 women during their first trimester in Morelos, Mexico. Two functional polymorphisms of the key folate-metabolizing gene, i.e. MTHFR 677 C>T and 1298 A>C, as well as global DNA methylation were assessed in peripheral blood drawn during the interview.
  
  
  RESULTS
  Independent of maternal age and caloric intake, vitamin B(6) deficiency was associated with 1.8 fold increased risk of hypomethylation in women carrying the MTHFR 677 T allele.
  
  
  CONCLUSIONS
  There exists a subpopulation that is more susceptible to B vitamin deficiencies.
authors: Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. michele.lamerrill@mssm.edu
authors: Michele
authors: M
authors: La Merrill
authors: Luisa
authors: L
authors: Torres-Sánchez
authors: Rubén
authors: R
authors: Ruiz-Ramos
authors: Lizbeth
authors: L
authors: López-Carrillo
authors: Mariano E
authors: ME
authors: Cebrián
authors: Jia
authors: J
authors: Chen
mesh_terms: D000328:Adult; D019175:DNA Methylation; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008423:Maternal Age; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D018977:Micronutrients / Q000172:deficiency*; D009752:Nutritional Status; D011247:Pregnancy / Q000378:metabolism*; D011261:Pregnancy Trimester, First; D055815:Young Adult
chemical_list: D018977:Micronutrients; D042965:Methylenetetrahydrofolate Reductase (NADPH2)