title: "Clip" and "click" chemistries combination: toward easy PEGylation of degradable aliphatic polyesters.
abstract: α-Methoxy-ω-alkyne poly(ethylene glycol) (PEG) was tagged with pendent N-hydroxy-succinimidyl activated esters by photografting of a molecular clip. This easily synthesized heterofunctional PEG was found to be a versatile building block for (i) conjugation with an amino derivative and (ii) grafting to azido functional aliphatic polyesters backbone by Huisgen's 1,3-dipolar cycloaddition. This original combination of "clip" and "click" reactions provides a versatile and straightforward pathway for the synthesis of functional amphiphilic and degradable copolymers valuable for biomedical applications such as in drug-delivery.
authors: Center for Education and Research on Macromolecules (CERM), University of Liège, Sart-Tilman B6a, B-4000 Liège, Belgium.
authors: Hélène
authors: H
authors: Freichels
authors: Vincent
authors: V
authors: Pourcelle
authors: Cécile S
authors: CS
authors: Le Duff
authors: Jacqueline
authors: J
authors: Marchand-Brynaert
authors: Christine
authors: C
authors: Jérôme
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis*; D057930:Click Chemistry; D011091:Polyesters / Q000138:chemical synthesis*; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D011091:Polyesters; D011092:Polyethylene Glycols