title: Heterothallic mating in Mucor irregularis and first isolate of the species outside of Asia.
abstract: This study reports on the discovery of heterothallic mating in Mucor irregularis (formerly Rhizomucor variabilis var. variabilis) and it extends the range of this species from Asia to the United States. We report on a case of primary cutaneous mucormycosis, involving the forearms of a cotton farmer from North Carolina, in which the infection was cured using amphotericin B therapy. Intraspecific crosses between the North Carolina strain DUMC 150.04 and M. irregularis CBS 103.93, the ex-type strain of R. variabilis var. variabilis from China, resulted in the formation of abundant fertile zygospores. By way of contrast, interspecific crosses between the North Carolina isolate and the ex-neotype strain of M. hiemalis NRRL 3624 resulted in the formation of putative azygospores by M. irregularis DUMC 150.04.
authors: Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, USA. wiley.schell@duke.edu
authors: Wiley A
authors: WA
authors: Schell
authors: Kerry
authors: K
authors: O'Donnell
authors: J Andrew
authors: JA
authors: Alspaugh
mesh_terms: D000383:Agriculture; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D003433:Crosses, Genetic; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D005542:Forearm / Q000382:microbiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009091:Mucormycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D009657:North Carolina; D020648:Peptide Elongation Factor 1 / Q000235:genetics; D010802:Phylogeny; D020103:Rhizomucor / Q000254:growth & development / Q000302:isolation & purification* / Q000502:physiology*; D017422:Sequence Analysis, DNA; D013172:Spores, Fungal / Q000166:cytology; D015053:Zygote
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D004275:DNA, Ribosomal; D020648:Peptide Elongation Factor 1; D000666:Amphotericin B