title: The role of p63 in cancer, stem cells and cancer stem cells.
abstract: The transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic, are involved in various cell processes. This review summarizes the current understanding of the role of p63 in tumorigenesis, metastasis, cell migration and senescence. In particular, recent data indicate important roles in adult stem cell and cancer stem cell regulation and in the response of cancer cells to therapy.
authors: Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653, Brno, Czech Republic.
authors: Marta
authors: M
authors: Nekulova
authors: Jitka
authors: J
authors: Holcakova
authors: Philip
authors: P
authors: Coates
authors: Borivoj
authors: B
authors: Vojtesek
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D013234:Stem Cells / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D020033:Protein Isoforms; C115051:TP63 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins