title: A pilot study of combined working memory and inhibition training for children with AD/HD.
abstract: Building on recent favourable outcomes using working memory (WM) training, this study examined the behavioural and physiological effect of concurrent computer-based WM and inhibition training for children with attention-deficit hyperactivity disorder (AD/HD). Using a double-blind active-control design, 29 children with AD/HD completed a 5-week at-home training programme and pre- and post-training sessions which included the assessment of overt behaviour, resting EEG, as well as task performance, skin conductance level and event-related potentials (ERPs) during a Go/Nogo task. Results indicated that after training, children from the high-intensity training condition showed reduced frequency of inattention and hyperactivity symptoms. Although there were trends for improved Go/Nogo performance, increased arousal and specific training effects for the inhibition-related N2 ERP component, they failed to reach standard levels of statistical significance. Both the low- and high-intensity conditions showed resting EEG changes (increased delta, reduced alpha and theta activity) and improved early attention alerting to Go and Nogo stimuli, as indicated by the N1 ERP component, post-training. Despite limitations, this preliminary work indicates the potential for cognitive training that concurrently targets the interrelated processes of WM and inhibition to be used as a treatment for AD/HD.
authors: Brain and Behaviour Research Institute and School of Psychology, University of Wollongong, NSW, Australia. sjohnsto@uow.edu.au
authors: Stuart J
authors: SJ
authors: Johnstone
authors: Steven
authors: S
authors: Roodenrys
authors: Elise
authors: E
authors: Phillips
authors: Annele J
authors: AJ
authors: Watt
authors: Sharlene
authors: S
authors: Mantz
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D058256:Brain Waves / Q000502:physiology; D002648:Child; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D010865:Pilot Projects; D011597:Psychomotor Performance / Q000502:physiology; D013813:Therapy, Computer-Assisted / Q000379:methods