title: The actin associated protein palladin in smooth muscle and in the development of diseases of the cardiovasculature and in cancer.
abstract: Palladin is an actin associated protein serving as a cytoskeleton scaffold, and actin cross linker, localizing at stress fibers, focal adhesions, and other actin based structures. Recent studies showed that palladin plays a critical role in smooth muscle differentiation, migration, contraction, and more importantly contributes to embryonic development. This review will focus on the functions and possible mechanisms of palladin in smooth muscle and in pathological conditions such as cardiovascular diseases and cancers.
authors: Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA. LJ7Q@virginia.edu
authors: Li
authors: L
authors: Jin
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology; D002454:Cell Differentiation / Q000502:physiology; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000503:physiopathology; D003598:Cytoskeletal Proteins / Q000032:analysis / Q000737:chemistry / Q000172:deficiency / Q000378:metabolism; D005260:Female; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009119:Muscle Contraction / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000503:physiopathology; D010750:Phosphoproteins / Q000032:analysis / Q000737:chemistry / Q000172:deficiency / Q000378:metabolism; D020033:Protein Isoforms; D015398:Signal Transduction
chemical_list: D000199:Actins; D003598:Cytoskeletal Proteins; C412722:PALLD protein, human; D010750:Phosphoproteins; D020033:Protein Isoforms; C485873:palladin protein, mouse