title: Inhibition of 2',5'-oligoadenylate synthetase expression and function by the human cytomegalovirus ORF94 gene product.
abstract: The human cytomegalovirus (HCMV) ORF94 gene product has been reported to be expressed during both productive and latent phases of infection, although its function is unknown. We report that expression of pORF94 leads to decreased 2',5'-oligoadenylate synthetase (OAS) expression in transfected cells with and without interferon stimulation. Furthermore, the functional activity of OAS was inhibited by pORF94. Finally, we present evidence of OAS modulation by pORF94 during productive HCMV infection of human fibroblasts. This study provides the first identification of a function for pORF94 and identifies an additional means by which HCMV may limit a critical host cell antiviral response.
authors: Centre for Virus Research, Westmead Millennium Institute, and the University of Sydney, Westmead, NSW, Austalia.
authors: Joanne C G
authors: JC
authors: Tan
authors: Selmir
authors: S
authors: Avdic
authors: John Z
authors: JZ
authors: Cao
authors: Edward S
authors: ES
authors: Mocarski
authors: Kirsten L
authors: KL
authors: White
authors: Allison
authors: A
authors: Abendroth
authors: Barry
authors: B
authors: Slobedman
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000472:pathogenicity*; D005347:Fibroblasts / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D014764:Viral Proteins / Q000378:metabolism*; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D014764:Viral Proteins; D037521:Virulence Factors; D015088:2',5'-Oligoadenylate Synthetase