title: Expressions of CXCR7/ligands may be involved in oral carcinogenesis.
abstract: Oral carcinogenesis is a multistep process and requires accumulation and interplay of a series of molecular events. Chemokines and their receptors have been suggested to play important roles in the initiation or progression of cancers. Until now, no report focuses on their alterations in premalignant stage of oral squamous cell carcinoma (OSCC). Compared with normal tissues, mRNA levels of 9 chemokines and 3 chemokine receptors including CXCR7 in oral leukoplakia (OLK) were increased more than two folds by microarray analysis. Then, CXCR7 was selected for further confirmation and immunohistochemistry examination during multistage oral carcinogenesis. CXCR7 was expressed in 85% of OLK and 86% of OSCC. However, only 8% (1 of 13 cases) of normal tissue displayed CXCR7 immunostaining. The positive ratios of CXCR7, CXCL12 and CXCL11 in OLK and OSCC tissues respectively, were significantly higher than that in normal epithelia (P < 0.05), although no significant difference was found between OLK and OSCC. Meanwhile, CXCR7 always concomitantly expressed with it ligands in OLK and OSCC tissues. Our results indicated that CXCR7-CXCL12/CXCL11 axis might play important roles in oral carcinogenesis.
authors: Department of Oral Medicine, Guanghua School of Stomatology and Institute of Stomatological Research, Sun Yat-Sen University, No. 56, Lingyuanxi Road, 510055, Guangzhou, Guangdong, People's Republic of China.
authors: Juan
authors: J
authors: Xia
authors: Juan
authors: J
authors: Wang
authors: Na
authors: N
authors: Chen
authors: Yaohui
authors: Y
authors: Dai
authors: Yun
authors: Y
authors: Hong
authors: Xiaobing
authors: X
authors: Chen
authors: Bin
authors: B
authors: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D054371:Chemokine CXCL11 / Q000235:genetics / Q000378:metabolism*; D054377:Chemokine CXCL12 / Q000235:genetics / Q000378:metabolism*; D018925:Chemokines / Q000235:genetics / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D020869:Gene Expression Profiling; D006801:Humans; D007972:Leukoplakia, Oral / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008024:Ligands; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D054387:Receptors, CXCR / Q000235:genetics* / Q000378:metabolism; D019707:Receptors, Chemokine / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: C501896:ACKR3 protein, human; C515202:CXCL11 protein, human; C515255:CXCL12 protein, human; D054371:Chemokine CXCL11; D054377:Chemokine CXCL12; D018925:Chemokines; D008024:Ligands; D054387:Receptors, CXCR; D019707:Receptors, Chemokine