title: Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical.
abstract: Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer's disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.
authors: Department of Bio-functional Science, Kyushu University, 3-1-1 Maidashi, Fukuoka, Japan.
authors: Fumiya
authors: F
authors: Mito
authors: Toshihide
authors: T
authors: Yamasaki
authors: Yuko
authors: Y
authors: Ito
authors: Mayumi
authors: M
authors: Yamato
authors: Hiroyuki
authors: H
authors: Mino
authors: Hiromi
authors: H
authors: Sadasue
authors: Chisato
authors: C
authors: Shirahama
authors: Kiyoshi
authors: K
authors: Sakai
authors: Hideo
authors: H
authors: Utsumi
authors: Ken-ichi
authors: K
authors: Yamada
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D000682:Amyloid / Q000032:analysis* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000032:analysis* / Q000378:metabolism; D052160:Benzothiazoles; D004578:Electron Spin Resonance Spectroscopy; D005456:Fluorescent Dyes / Q000032:analysis* / Q000138:chemical synthesis; D006801:Humans; D009589:Nitrogen Oxides / Q000032:analysis* / Q000138:chemical synthesis; D010084:Oxidation-Reduction; D013050:Spectrometry, Fluorescence; D013113:Spin Labels / Q000138:chemical synthesis; D013844:Thiazoles / Q000032:analysis
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D052160:Benzothiazoles; D005456:Fluorescent Dyes; D009589:Nitrogen Oxides; D013113:Spin Labels; D013844:Thiazoles; C009462:thioflavin T; C039900:nitroxyl