title: Demographic determinants of risk, colon distribution and density scores of diverticular disease.
abstract: OBJECTIVE
  To investigate associations between ethnicity, age and sex and the risk, colon distribution and density scores of diverticular disease (DD).
  
  
  METHODS
  Barium enemas were examined in 1000 patients: 410 male, 590 female; 760 whites, 62 Asians, 44 black africans (BAs), and 134 other blacks (OBs). Risks and diverticula density of left-sided DD (LSDD) and right-sided-component DD (RSCDD = right-sided DD + right and left DD + Pan-DD) were compared using logistic regression.
  
  
  RESULTS
  Four hundred and forty-seven patients had DD (322 LSDD and 125 RSCDD). Adjusted risks: (1) LSDD: each year increase in age increased the odds by 6% (95% CI: 5-8, SE: 0.8%, P < 0.001); Asians: odds ratio (OR): 0.23 (95% CI: 0.10-0.53, SE: 0.1, P ≤ 0.001) and OBs: OR: 0.25 (95% CI: 0.14-0.43, SE: 0.07, P ≤ 0.001) appeared protected vs Whites; (2) RSCDD: each year increase in age increased the odds by 4% (95% CI: 2-6, SE: 1%, P < 0.001); females were 0.60 times (95% CI: 0.40-0.90, SE: 0.12, P = 0.01) less likely than males to have RSCDD; BAs were 3.51 times (95% CI: 1.70-7.24, SE: 1.30, P < 0.001) more likely than Whites to have RSCDD; and (3) DD density scores: each year increase in age increased the odds of high-density scores by 4% (95% CI: 1-6, SE: 1%, P < 0.001); RSCDD was 2.77 times (95% CI: 1.39-3.32, SE: 0.67, P < 0.001) more likely to be of high density than LSDD. No further significant differences were found in the adjusted models.
  
  
  CONCLUSIONS
  Right colonic DD might be more common and has higher diverticula density in the west than previously reported. BAs appear predisposed to DD, whereas other ethnic differences appear conserved following migration.
authors: Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University, United Kingdom. email@msgolder.co.uk
authors: Mark
authors: M
authors: Golder
authors: Irina Chis
authors: IC
authors: Ster
authors: Pratusha
authors: P
authors: Babu
authors: Amita
authors: A
authors: Sharma
authors: Muhammad
authors: M
authors: Bayat
authors: Abdulkadir
authors: A
authors: Farah
mesh_terms: D000367:Age Factors; D017609:Barium Compounds; D003106:Colon / Q000473:pathology*; D004241:Diverticulum, Colon / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology*; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D017609:Barium Compounds