title: Comparison of intracerebral delivery of carboplatin and photon irradiation with an optimized regimen for boron neutron capture therapy of the F98 rat glioma.
abstract: In this report we have summarized our studies to optimize the delivery of boronophenylalanine (BPA) and sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) of F98 glioma bearing rats. These results have been compared to a chemoradiotherapeutic approach using the same tumor model. The best survival data from our BNCT studies were obtained using a combination of BPA and sodium borocaptate BSH administered via the internal carotid artery, in combination with blood-brain barrier disruption (BBB-D). This treatment resulted in a mean survival time (MST) of 140 d with a 25% cure rate. The other approach combined intracerebral administration of carboplatin by either convection enhanced delivery (CED) or Alzet pump infusion, followed by external beam photon irradiation. This resulted in MSTs of 83 d and 112 d, respectively, with a cure rate of 40% for the latter. However, a significant problem that must be solved for both BNCT and this new chemoradiotherapeutic approach is how to improve drug uptake and microdistribution within the tumor.
authors.affiliation: Department of Pathology, The Ohio State University, Columbus, OH 43210, USA. rolf.barth@osumc.edu
authors.forename: Rolf F
authors.initials: RF
authors.lastname: Barth
authors.forename: Weilian
authors.initials: W
authors.lastname: Yang
authors.forename: Tianyao
authors.initials: T
authors.lastname: Huo
authors.forename: Kent J
authors.initials: KJ
authors.lastname: Riley
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Binns
authors.forename: John C
authors.initials: JC
authors.lastname: Grecula
authors.forename: Nilendu
authors.initials: N
authors.lastname: Gupta
authors.forename: Julia
authors.initials: J
authors.lastname: Rousseau
authors.forename: Hélène
authors.initials: H
authors.lastname: Elleaume
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005910:Glioma / Q000188:drug therapy / Q000532:radiotherapy*; D017785:Photons; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin