title: Guideline for the classification of the acute emetogenic potential of antineoplastic medication in pediatric cancer patients.
abstract: This guideline provides clinicians caring for children with an approach to assessing the acute emetogenic potential of antineoplastic therapies. It was developed by an international, inter-professional panel of clinicians and researchers using AGREE and CAN-ADAPTE methods. The emetogenicity of antineoplastic agents was evaluated and ranked as high, moderate, low, or minimal. The emetogenicity of multiple-agent and multiple-day antineoplastic therapy was also classified. Gaps in the evidence used to underpin the guideline recommendations were identified. The contribution of this guideline to the prevention of antineoplastic-induced nausea and vomiting in individual children about to receive antineoplastic therapy requires prospective evaluation.
authors.affiliation: Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada. lee.dupuis@sickkids.ca
authors.forename: L Lee
authors.initials: LL
authors.lastname: Dupuis
authors.forename: Sabrina
authors.initials: S
authors.lastname: Boodhan
authors.forename: Lillian
authors.initials: L
authors.lastname: Sung
authors.forename: Carol
authors.initials: C
authors.lastname: Portwine
authors.forename: Richard
authors.initials: R
authors.lastname: Hain
authors.forename: Patricia
authors.initials: P
authors.lastname: McCarthy
authors.forename: Mark
authors.initials: M
authors.lastname: Holdsworth
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000145:classification*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000145:classification; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy*; D018570:Risk Assessment; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents