title: Development and characterization of doxorubicin loaded microparticles against experimental visceral leishmaniasis.
abstract: Visceral leishmaniasis (VL) is the most severe of all the forms of leishmaniasis and usually lethal if untreated. The present work aimed to develop and characterize doxorubicin loaded mannan conjugated microparticles against experimental visceral leishmaniasis for selective and targeted delivery of doxorubicin to the macrophages of liver and spleen for the effective chemotherapy of VL. Macrophage targeting using doxorubicin loaded PLGA-microparticles would certainly improve the chemotherapy with reduced side effects against VL.
authors.affiliation: Nanomedicine Research Centre, Department of Pharmaceutics, I.S.F College of Pharmacy, Moga 142001, India.
authors.forename: Sheeshpal
authors.initials: S
authors.lastname: Sharma
authors.forename: Pankaj
authors.initials: P
authors.lastname: Kumar
authors.forename: Anil
authors.initials: A
authors.lastname: Jaiswal
authors.forename: Anuradha
authors.initials: A
authors.lastname: Dube
authors.forename: Swati
authors.initials: S
authors.lastname: Gupta
mesh_terms: D002214:Capsules; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis*; D007891:Leishmania / Q000187:drug effects* / Q000502:physiology*
chemical_list: D002214:Capsules; D004337:Drug Carriers; D004317:Doxorubicin