title: One-pot synthesis of hybrid macrocyclic pentamers with variable functionalizations around the periphery.
abstract: Rather than four- or six-residue macrocylces, one-pot macrocyclization allows for the highly selective formation of five-residue macrocycles rigidified by intramolecular hydrogen bonds. Variable functionalizations around the pentameric periphery were achieved by reacting monomers with higher oligomers bearing different exterior side chains. The formation of these hybrid pentamers suggests a chain-growth mechanism for the one-pot macrocyclization where the successive addition of monomers onto higher oligomers is faster than those between two monomers or two higher oligomers.
authors.affiliation: Department of Chemistry and NUS MedChem Program of the Office of Life Sciences, 3 Science Drive 3, National University of Singapore, Singapore 117543, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Qin
authors.forename: Chang
authors.initials: C
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Ye
authors.forename: Jia
authors.initials: J
authors.lastname: Zhu
authors.forename: Xin-Fang
authors.initials: XF
authors.lastname: Duan
authors.forename: Huaqiang
authors.initials: H
authors.lastname: Zeng
mesh_terms: D003500:Cyclization; D006860:Hydrogen Bonding; D047028:Macrocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D047028:Macrocyclic Compounds