title: Immune pancytopenia associated with a leukemic B-cell tumor carrying t(14;18)(q32;q21) translocation.
abstract: We report a 75-year-old man who was initially suggested to have acute leukemia. The hemoglobin level was 3.8 g/dL, white cell count was 7,700/µL with an absence of mature neutrophils and 69.0% leukemic cells, and platelet was 0.4 × 10(4)/µL. Coombs' antiglobulin test was positive. Leukemic cells were CD5(-), CD10(+), CD20(+), CD23(-), and IgG/λ(dim+). The bone marrow consisted of normal hematopoietic precursors, whereas fluorescence in situ hybridization detected the BCL2/IgH fusion gene. He was treated with rituximab-containing chemotherapy, resulting in the resolution of pancytopenia. The underlying disease was a leukemic B-cell tumor with t(14;18)(q32;q21), and the pancytopenia was mainly caused by autoimmune mechanisms.
authors.affiliation: Department of Hematology, Takeda General Hospital, Japan.
authors.forename: Chisaki
authors.initials: C
authors.lastname: Mizumoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohno
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Katsurada
authors.forename: Shigeru
authors.initials: S
authors.lastname: Oguma
authors.forename: Yataro
authors.initials: Y
authors.lastname: Yoshida
mesh_terms: D000368:Aged; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D006801:Humans; D015448:Leukemia, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D010198:Pancytopenia / Q000175:diagnosis / Q000209:etiology*; D000069283:Rituximab; D014178:Translocation, Genetic / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab