title: [Cathepsin-like activity in blood plasma of patients with papillary thyroid carcinoma].
abstract: The peculiarities of the thyroid changes depending on clinical characteristics of disease and histological structure of tumor were fixed by the studies of cathepsin-like activity in blood plasma of patients with papillary thyroid carcinoma. H-cathepsin-like activity had a tendence to more significant increase especially in patients with concomitant benign thyroid disease with increasing the tumor category. In a case of metastatic tumor without other concomitant thyroid pathology, the degree of an increase in enzymatic activity was significantly higher comparing to the blood of patients without tumor metastases. B-cathepsin-like activity in blood plasma of patients only with tumor carcinoma was at the level of that of healthy subjects. B-cathepsin-like activity in blood plasma had especially significant increased under tumor T1 category that was connected with nodular goiter or adenoma in a case concominant carcinoma by other thyroid pathology. In patients with carcinoma that was diagnosed against a background of concomitant pathology, the insignificant increase in L-cathepsin-like activity was not dependent on clinical features of disease, while in a case of carcinoma without concomitant pathology a degree of its increase was certainly dependent on a category of tumor T, its histological structure and the presence of oxyphilic cell metaplasia. We failed to get an evidence linking the changes in cathepsin-like activity in blood with the processes of intra- or extrathyroid invasion and invasion into the lymphatic or blood vessels. The results of the studies do not provide a rationale to consider that the cathepsin-like activity in blood of patients with papillary thyroid carcinoma can be the valuable additional biochemical criterion for differential diagnosis, estimation of the severity, and other characteristics of the disease.
authors.forename: O V
authors.initials: OV
authors.lastname: Kalinichenko
authors.forename: T M
authors.initials: TM
authors.lastname: Myshunina
authors.forename: M D
authors.initials: MD
authors.lastname: Tron'ko
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002291:Carcinoma, Papillary / Q000097:blood* / Q000473:pathology; D002403:Cathepsins / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D013964:Thyroid Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: D015415:Biomarkers; D002403:Cathepsins