title: Synthesis of biodegradable polymeric nanoparticles and their controlled drug delivery for tuberculosis.
abstract: Tuberculosis (TB) is the leading cause of infectious diseases affecting the 2 billion people worldwide. To improve the current method of treatment a synthetic polymeric anti-TB nanodrug delivery system was attempted. A series of PLGA polymers with different molar feed ratios i.e., 90/10, 75/25, 50/50 were synthesized by direct melt polycondensation method. The PLGA nanoparticles and the drug (Rifampicin (RIF)) encapsulation were prepared by double emulsion-solvent evaporation technique. The in vitro release profile of the RIF loaded PLGA NPs showed an initial burst followed by sustained release. The nanoparticles were remarkably advantageous in terms of high drug encapsulation efficiency, low polymer consumption and better sustained release profile.
authors.affiliation: Department of Inorganic Chemistry, University of Madras, Maraimalai Campus, Chennai 600025, India.
authors.forename: S
authors.initials: S
authors.lastname: Malathi
authors.forename: S
authors.initials: S
authors.lastname: Balasubramanian
mesh_terms: D020341:Absorbable Implants; D000995:Antitubercular Agents / Q000737:chemistry / Q000627:therapeutic use; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012293:Rifampin / Q000737:chemistry* / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012293:Rifampin