title: Emergence of keratin 17 vs. loss of keratin 13: their reciprocal immunohistochemical profiles in oral carcinoma in situ.
abstract: To evaluate differential expressions for keratin (K) subtypes 13 and 17 in oral borderline malignancies, we examined 67 surgical specimens of the oral mucosa for their immunohistochemical profiles. From those specimens, 173 foci of epithelial dysplasia, 152 foci of carcinoma in situ (CIS), and 82 foci of squamous cell carcinoma (SCC) were selected according to our diagnostic criteria, along with 20 areas of normal epithelia. In normal epithelia, there was no K17 positivity (0%), whereas definite K13 positivity (100%) was observed. The same tendencies were obtained in mild (undefined) and moderate (true) epithelial dysplasias (K17: 0%; K13: 100%). In contrast, all CIS (100%) had K17 positivities, while K13 positivities were lost in many of them (7%). Similar tendencies were confirmed in invasive SCC (K17: 100%, K13: 4%). Simultaneous immunopositivities for K17 and K13 were found only in SCC (7%) and CIS (4%) foci with distinct keratinization. These foci also showed K10 positivities, though K10 positive areas were not identical to K13 positive areas. The results indicate that expressions of K17 and K13 are reciprocal in oral epithelial lesions and that the K17 emergence is related to malignancies.
authors.affiliation: Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Mikami
authors.forename: Jun
authors.initials: J
authors.lastname: Cheng
authors.forename: Satoshi
authors.initials: S
authors.lastname: Maruyama
authors.forename: Takanori
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Akinori
authors.initials: A
authors.lastname: Funayama
authors.forename: Manabu
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Henry A
authors.initials: HA
authors.lastname: Adeola
authors.forename: Lanyan
authors.initials: L
authors.lastname: Wu
authors.forename: Susumu
authors.initials: S
authors.lastname: Shingaki
authors.forename: Chikara
authors.initials: C
authors.lastname: Saito
authors.forename: Takashi
authors.initials: T
authors.lastname: Saku
mesh_terms: D002278:Carcinoma in Situ / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D004848:Epithelium / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D053535:Keratin-13 / Q000378:metabolism*; D053537:Keratin-17 / Q000378:metabolism*; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology; D011230:Precancerous Conditions / Q000378:metabolism* / Q000473:pathology
chemical_list: D053535:Keratin-13; D053537:Keratin-17