title: Scaffolds for bone healing: concepts, materials and evidence.
abstract: Critical sized bone defects have to be filled with material to allow bone healing. The golden standard for this treatment is autogenous bone grafting. Because of donor size morbidity, equivalent synthetic bone scaffolds should be developed. Different materials, especially ceramics and polymers are in the focus of research. Calcium phosphate ceramics show similar properties to bone and are degradable. Different modifications can improve the bioactive features. This article gives an overview about the current materials and their evidence of clinical use.
authors.affiliation: Department of Trauma Surgery, University Hospital of the RWTH Aachen, Aachen, Germany. plichte@ukaachen.de
authors.forename: P
authors.initials: P
authors.lastname: Lichte
authors.forename: H C
authors.initials: HC
authors.lastname: Pape
authors.forename: T
authors.initials: T
authors.lastname: Pufe
authors.forename: P
authors.initials: P
authors.lastname: Kobbe
authors.forename: H
authors.initials: H
authors.lastname: Fischer
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000295:instrumentation / Q000379:methods*; D002130:Calcium Phosphates / Q000627:therapeutic use; D002516:Ceramics / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D005593:Fracture Fixation, Internal / Q000295:instrumentation*; D017102:Fracture Healing / Q000502:physiology*; D006801:Humans; D010012:Osteogenesis / Q000502:physiology*; D023822:Tissue Engineering / Q000295:instrumentation; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass; D002130:Calcium Phosphates