title: Economic value of Acinetobacter baumannii screening in the intensive care unit.
abstract: Although Acinetobacter baumannii (A. baumannii) is an increasingly common nosocomial pathogen that can cause serious infections in the intensive care unit (ICU), most ICUs do not actively screen admissions for this pathogen. We developed an economic computer simulation model to determine the potential cost-consequences to the hospital of implementing routine A. baumannii screening of ICU admissions and isolating those patients who tested positive, comparing two screening methods, sponge and swab, with each other and no screening. Sensitivity analyses varied the colonization prevalence, percentage of colonized individuals who had active A. baumannii infections, A. baumannii reproductive rate (R), and contact isolation efficacy. Both screening methods were cost-effective for almost all scenarios tested, yielding cost-savings ranging from -$1 to -$1563. Sponge screening was not cost-saving when colonization prevalence was ≤1%, probability of infection ≤30%, R ≤ 0.25, and contact isolation efficacy ≤25%. Swab screening was not cost-saving under these same conditions when the probability of infection was ≤40%. Sponge screening tended to be more cost-saving than swab screening (additional savings ranged from $1 to $421). Routine A. baumannii screening of ICU patients may save costs for hospitals.
authors.affiliation: Public Health Computational and Operations Research, University of Pittsburgh, Pittsburgh, PA 15213, USA. BYL1@pitt.edu
authors.forename: B Y
authors.initials: BY
authors.lastname: Lee
authors.forename: S M
authors.initials: SM
authors.lastname: McGlone
authors.forename: Y
authors.initials: Y
authors.lastname: Doi
authors.forename: R R
authors.initials: RR
authors.lastname: Bailey
authors.forename: L H
authors.initials: LH
authors.lastname: Harrison
mesh_terms: D000151:Acinetobacter Infections / Q000175:diagnosis* / Q000191:economics / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000302:isolation & purification*; D003198:Computer Simulation; D003362:Cost-Benefit Analysis; D003428:Cross Infection / Q000191:economics / Q000382:microbiology / Q000517:prevention & control*; D003955:Diagnostic Tests, Routine / Q000191:economics* / Q000379:methods*; D006801:Humans; D007362:Intensive Care Units; D008403:Mass Screening / Q000191:economics* / Q000379:methods*; D015233:Models, Statistical