title: Interleukin-6 in surgery, trauma, and critical care part II: clinical implications.
abstract: A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention.
authors.affiliation: Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA. rjawa@unmc.edu
authors.forename: Randeep S
authors.initials: RS
authors.lastname: Jawa
authors.forename: Sergio
authors.initials: S
authors.lastname: Anillo
authors.forename: Kristin
authors.initials: K
authors.lastname: Huntoon
authors.forename: Heinz
authors.initials: H
authors.lastname: Baumann
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Kulaylat
mesh_terms: D016638:Critical Illness; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology; D015850:Interleukin-6 / Q000502:physiology*; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications
chemical_list: D015850:Interleukin-6