title: Metastasis suppressors: basic and translational advances.
abstract: Tumor metastasis is a main contributor to death in cancer patients. In the last years, a new class of molecules that reduces the metastatic propensity has been identified: metastasis suppressors. These proteins regulate multiple steps in the metastatic cascade, including cell invasion, survival in the vascular and lymphatic circulation, and colonization of distant organ sites. As a consequence, they are very important therapeutic targets. This review discusses our current understanding of metastasis suppressors and how this knowledge might be useful to improve the treatment of cancer patients.
authors.affiliation: Research Area. Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: C
authors.initials: C
authors.lastname: Buchanan
authors.forename: M A
authors.initials: MA
authors.lastname: Lago Huvelle
authors.forename: M G
authors.initials: MG
authors.lastname: Peters
mesh_terms: D000818:Animals; D000077868:Atrasentan; D019332:Endothelin-1 / Q000037:antagonists & inhibitors; D016147:Genes, Tumor Suppressor; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D011759:Pyrrolidines / Q000627:therapeutic use; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D019332:Endothelin-1; D011759:Pyrrolidines; D025521:Tumor Suppressor Proteins; D000077868:Atrasentan