title: [Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia].
abstract: The polypeptide drug cortexin and the synthetic peptide drug cortagen accelerate the recovery of disturbed individual behavior of ischemic rats with different resistance to hypoxia (high and low resistant rats). In addition, both drugs prevented an excessive activation of lipid peroxidation and a decrease in the antioxidant activity in the brain tissues. The obtained results suggest that cortexin and cortagen can be used for increasing the efficacy of neuroprotective therapy in cases of chronic brain ischemia.
authors.forename: I V
authors.initials: IV
authors.lastname: Zarubina
authors.forename: P D
authors.initials: PD
authors.lastname: Shabanov
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005106:Exploratory Behavior / Q000187:drug effects; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009842:Oligopeptides / Q000627:therapeutic use*; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; D010455:Peptides; C431545:alanyl-glutamyl-aspartylprolyine; C056590:cortexin