title: Hard x-ray Zernike microscopy reaches 30 nm resolution.
abstract: Since its invention in 1930, Zernike phase contrast has been a pillar in optical microscopy and more recently in x-ray microscopy, in particular for low-absorption-contrast biological specimens. We experimentally demonstrate that hard-x-ray Zernike microscopy now reaches a lateral resolution below 30 nm while strongly enhancing the contrast, thus opening many new research opportunities in biomedicine and materials science.
authors.affiliation: Institute of Physics, Academia Sinica, Taipei 115, Taiwan.
authors.forename: Yu-Tung
authors.initials: YT
authors.lastname: Chen
authors.forename: Tsung-Yu
authors.initials: TY
authors.lastname: Chen
authors.forename: Jaemock
authors.initials: J
authors.lastname: Yi
authors.forename: Yong S
authors.initials: YS
authors.lastname: Chu
authors.forename: Wah-Keat
authors.initials: WK
authors.lastname: Lee
authors.forename: Cheng-Liang
authors.initials: CL
authors.lastname: Wang
authors.forename: Ivan M
authors.initials: IM
authors.lastname: Kempson
authors.forename: Y
authors.initials: Y
authors.lastname: Hwu
authors.forename: Vincent
authors.initials: V
authors.lastname: Gajdosik
authors.forename: G
authors.initials: G
authors.lastname: Margaritondo
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D018920:Coculture Techniques; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles; D051379:Mice; D008853:Microscopy / Q000379:methods*; D011137:Polystyrenes / Q000737:chemistry; D014965:X-Rays
chemical_list: D011137:Polystyrenes; D006046:Gold