title: Effect of intraoral low-level laser therapy on quality of life of patients with head and neck cancer undergoing radiotherapy.
abstract: BACKGROUND
  Low-level laser therapy has been used to reduce complications of head and neck cancer treatment. The aim was to assess the impact of laser in the quality of life (QOL) of patients receiving radiotherapy.
  
  
  METHODS
  Sixty outpatients were randomly assigned into 2 groups. The laser group received applications and the placebo group received sham laser. QOL was assessed using the University of Washington QOL questionnaire. A repeated-measures analysis of variance (ANOVA) was used for comparisons of overall QOL scores and Mann-Whitney test compared changes in domain scores.
  
  
  RESULTS
  A decrease in QOL scores was observed in both groups and the reduction in the laser group was significantly lower (p < .01). Changes in QOL scores regarding pain, chewing, and saliva domains were evident in the placebo group. Both health-related QOL and overall QOL were rated higher by patients who received laser therapy.
  
  
  CONCLUSIONS
  Laser therapy reduces the impact of radiotherapy on the QOL of patients with head and neck cancer.
authors.affiliation: Department of Oral Medicine (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil.
authors.forename: Angélica Ferreira
authors.initials: AF
authors.lastname: Oton-Leite
authors.forename: Annelise Carrilho
authors.initials: AC
authors.lastname: Corrêa de Castro
authors.forename: Marília Oliveira
authors.initials: MO
authors.lastname: Morais
authors.forename: Juliana Castro Dourado
authors.initials: JC
authors.lastname: Pinezi
authors.forename: Cláudio Rodrigues
authors.initials: CR
authors.lastname: Leles
authors.forename: Elismauro Francisco
authors.initials: EF
authors.lastname: Mendonça
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects; D015331:Cohort Studies; D019583:Dose Fractionation, Radiation; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications / Q000523:psychology / Q000628:therapy*; D006801:Humans; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D011788:Quality of Life; D020127:Recovery of Function; D013280:Stomatitis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents