title: Comparative study on antioxidant activity of lycopene (Z)-isomers in different assays.
abstract: Several studies have implicated the potent antioxidant properties of lycopene. However, most of the studies used only the (all-E)-isomer. (Z)-Isomers of lycopene were found in substantial amounts in processed foods and in human tissues. In the present study, we investigated in vitro the antioxidant activity of (5Z)-, (9Z)-, and (13Z)-lycopene compared to the (all-E)-isomer. Additionally, prolycopene, the (7Z,9Z,7'Z,9'Z)-isomer found in tangerine tomatoes, was analyzed. No significant differences were found between the isomers in ferric reducing antioxidant power assay and in bleaching the radical cation of 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), both based on ET mechanisms. In contrast, scavenging activity against peroxyl radicals generated by thermal degradation of 2,2'-azobis(2-amidinopropane) (AAPH) was higher in the (Z)-isomers. (5Z)-Lycopene was most antioxidant in scavenging lipid peroxyl radicals, evaluated by analyzing the inhibition of MbFe(III) lipid peroxidation of linoleic acid in mildly acidic conditions (pH 5.8) in a micellar environment, modeling a possible antioxidant action in the gastric compartment.
authors.affiliation: Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Müller
authors.forename: Pascale
authors.initials: P
authors.lastname: Goupy
authors.forename: Kati
authors.initials: K
authors.lastname: Fröhlich
authors.forename: Olivier
authors.initials: O
authors.lastname: Dangles
authors.forename: Catherine
authors.initials: C
authors.lastname: Caris-Veyrat
authors.forename: Volker
authors.initials: V
authors.lastname: Böhm
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D002338:Carotenoids / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical; D007536:Isomerism; D000077276:Lycopene
chemical_list: D000975:Antioxidants; D002338:Carotenoids; D000077276:Lycopene