title: Synthesis and DPPH radical scavenging activity of 5-arylidene-N,N-dimethylbarbiturates.
abstract: Twenty-four derivatives of N,N-dimethylbarbituric acid 1-24 were screened for their DPPH radical scavenging activity. These compounds showed an excellent antioxidant activity. A structure-activity relationship has been discussed, while all the synthetic compounds were characterized by spectroscopic techniques and elemental analysis.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan. khalid.khan@iccs.edu
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Momin
authors.initials: M
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
authors.forename: Muhammad
authors.initials: M
authors.lastname: Taha
authors.forename: Abdul
authors.initials: A
authors.lastname: Hameed
authors.forename: Sajjad
authors.initials: S
authors.lastname: Ali
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001463:Barbiturates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D001463:Barbiturates; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl