title: Cell penetrating peptides for tumor targeting.
abstract: Anticancer drug delivery has been hindered due to cell membrane permeability and the lack of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs and has therefore been considered to be an essential step for achieving therapeutic efficacy. While different types of transporters currently exist, cell penetrating peptides (CPPs) have become one of the most popular and effective tools for intracellular drug delivery. Most of the original CPPs are short peptides with basic residues. The mechanism of CPP cell entry remains to be established; however, the CPPs can deliver any type of molecular cargo including solid nanoparticles. Herein, this paper will discuss the classification of CPPs, the mechanism of cell entry, the application of CPPs in tumor therapy, and recent advances in targeted cell penetration that involve CPPs.
authors.affiliation: Department of Dental Regenerative Biotechnology, Dental Research Institute and School of Dentistry, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, Seoul 110-749, South Korea.
authors.forename: Young Suk
authors.initials: YS
authors.lastname: Choi
authors.forename: Jue Yeon
authors.initials: JY
authors.lastname: Lee
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Suh
authors.forename: Seung Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Victor C
authors.initials: VC
authors.lastname: Yang
authors.forename: Chong Pyoung
authors.initials: CP
authors.lastname: Chung
authors.forename: Yoon Jeong
authors.initials: YJ
authors.lastname: Park
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D057846:Cell-Penetrating Peptides / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D057846:Cell-Penetrating Peptides