title: FORS-D Analysis in P. falciparum can Differentiate Classes of Genes Under Selection.
abstract: FORS-D is a measure of the contribution of base order to the stem loop potential of a nucleic acid sequence and can also give information on evolutionary pressures on sequences to move away from secondary structure. Negative FORS-D values in a gene are associated with exons and nucleotide substitutions such as SNPs. An analysis of P. falciparum genes under selection pressure shows a correlation between negative FORS-D values and SNP density for genes that drug targets but not for drug transporters or antigenic variation genes. Analysis of the dhfr gene shows that a majority of rare mutations that associate with drug resistance also fall into regions with negative FORS-D values. These data suggest that FORS-D values might be predictors for drug target genes and drug resistance mutations in these genes.
authors.affiliation: Birla Institute of Technology and Science, Pilani, Goa Campus, Zuarinagar 403726, Goa, India.
authors.forename: Atish
authors.initials: A
authors.lastname: Kathpal
authors.forename: Balakota Reddy
authors.initials: BR
authors.lastname: Patakottu
authors.forename: Swati
authors.initials: S
authors.lastname: Patankar