title: Long-term outcomes of laparoscopic surgery versus open resection for middle and lower rectal cancer: an NTCLES study.
abstract: BACKGROUND
  Prognoses for treatment of middle and lower rectal cancer remain unclear because anatomical and complex surgical procedures specifically influence long-term outcomes. This study analyzes the long-term outcomes of laparoscopic versus open resection for middle and lower rectal cancer.
  
  
  METHODS
  Patients (laparoscopic, n = 113; open, n = 123) who underwent curative resection for middle and lower rectal cancer from 2000 to 2005 participated in the study. All operations were performed by the same surgical team with extensive experience in laparoscopic and open procedures. The mean follow-up time of all patients was 74.8 months.
  
  
  RESULTS
  No statistical differences in local recurrence rate (9.1% vs. 6.4%; log-rank = 0.432; p = 0.511) and in distant recurrence rate (19.7% vs. 15.5%; log-rank = 0.505; p = 0.477) between laparoscopic and open groups were observed within 5 years. The 5-year overall survival rates of the laparoscopic and open groups were 77.9 and 78.9%, respectively; no significant statistical difference was observed between them (log-rank = 0.012; p = 0.913). The 5-year survival rates between groups were not different between stages: stage I (91.7% vs. 92.0%; p = 0.950), stage II (82.8% vs. 79.4%; p = 0.643), and stage III (66.7% vs. 70.3%; p = 0.850). However, significant statistical differences between different stages were observed (log-rank = 11.156; p = 0.004).
  
  
  CONCLUSIONS
  Laparoscopic and open surgery for middle and lower rectal cancer offer similar long-term outcomes. The continued use of laparoscopic surgery in these patients can be supported.
authors.affiliation: Department of Colorectal and Anal Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, People's Republic of China.
authors.forename: Shaotang
authors.initials: S
authors.lastname: Li
authors.forename: Pan
authors.initials: P
authors.lastname: Chi
authors.forename: Huiming
authors.initials: H
authors.lastname: Lin
authors.forename: Xingrong
authors.initials: X
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
mesh_terms: D016009:Chi-Square Distribution; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000601:surgery* / Q000628:therapy; D018709:Statistics, Nonparametric; D015996:Survival Rate; D016896:Treatment Outcome