title: Association between serum C-reactive protein and metabolic syndrome in Mongolian patients in comparison to Japanese patients.
abstract: OBJECTIVE
  Metabolic syndrome (MetS) is associated with chronic inflammation and cardiovascular disease. The present study's aim was to investigate the relationship between serum C-reactive protein (CRP) and MetS in the Mongolian population in comparison to the Japanese population.
  
  
  METHODS
  Two-hundred and eighty-five Mongolian volunteers (males/females: 115/170, mean age 44.9 years) and 326 Japanese volunteers (males/females: 137/189, mean age 43.6 years) were recruited from health check-up settings. Cardiometabolic variables including CRP were measured. The patients were divided into three groups by the number of MetS risk factors (< 1, 1-2 or > or = 3).
  
  
  RESULTS
  The percentages of patients with MetS were 39.6% in the Mongolians and 31.1% in the Japanese. The median CRP levels were .05, .12 and .19 mg/dL in the < 1, 1-2 and > or =3 MetS risk factor groups among Mongolians, and .03, .05 and .07 mg/dL in these same groups among Japanese. The significance for the trend for CRP levels within each ethnic group was P < .001, and the significance for the difference in CRP levels between the respective groups by the MetS risk factors was P = .03 in subjects with < 1, P < .001 in subjects with 1-2, P < .001 in subjects with > or = 3. These results were similar in the subgroup analyses by sex.
  
  
  CONCLUSIONS
  While higher serum CRP levels were seen with increased MetS risk factors in both ethnic groups, in some cases we observed a higher serum CRP level increase in the Mongolian population than in the Japanese population. Mongolian people may be at greater risk for cardiovascular disease.
authors.affiliation: Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Uurtuya
authors.initials: U
authors.lastname: Shuumarjav
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Taniguchi
mesh_terms: D000328:Adult; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000208:ethnology*; D008875:Middle Aged; D008986:Mongolia / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein