title: The value of proton MR-spectroscopy in the differentiation of brain tumours from non-neoplastic brain lesions.
abstract: OBJECTIVE
  Our aim was to evaluate the efficacy of Proton-MR Spectroscopy for the differentiation of cranial masses from non-neoplastic brain disorders.
  
  
  METHODS
  33 patients with intracranial mass lesions, 29 patients with non-neoplastic brain lesions: Ischemic-demyelinating-metabolic-benign cystic mass group; As a whole 62 patients: 30 males and 32 females were included in this study.
  
  
  RESULTS
  In brain tumours, average Cho/NAA ratio 2.84-NAA/Cr ratio was 0.97, Cho/Cr ratio 2.42 and Cho/MI ratio was 3.51. In non-neoplastic group; NAA/Cr ratio was extremely higher than tumour group, the other ratios were far lower than cranial mass lesions. Average Cho/NAA ratio: 0.50 +/- 0.15, Cho/Cr ratio: 1.05 +/- 0.14, Cho/MI ratio: 1.07 +/- 0.73.
  
  
  CONCLUSIONS
  Higher Cho/NAA and Cho/MI ratios with lower NAA/Cr ratio were most likely to be malignant. Additional lipid and lactate peaks were generally seen in malignant group.
authors.affiliation: Dişkapi Yildirim Beyazit Research Hospital, Radiology Department, Ankara, Turkey. dr.hasanaydin@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Aydin
authors.forename: S
authors.initials: S
authors.lastname: Sipahioğlu
authors.forename: N Aydin
authors.initials: NA
authors.lastname: Oktay
authors.forename: E
authors.initials: E
authors.lastname: Altin
authors.forename: V
authors.initials: V
authors.lastname: Kizilgöz
authors.forename: B
authors.initials: B
authors.lastname: Hekimoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000737:chemistry* / Q000175:diagnosis*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline