title: Vascular co-option in lung cancer metastatic to the eye after treatment with bevacizumab.
abstract: BACKGROUND
  Chemotherapy with bevacizumab alters the angiogenic environment, and therefore, the growth and spread of metastases. We present a patient with metastatic lung adenocarcinoma to the eye with findings suggestive of retinal vascular co-option.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 57-year-old male, receiving systemic bevacizumab for metastatic lung adenocarcinoma, presented with vitreous opacities and clumped deposits adherent to the retinal vessels. No choroidal metastases were present. Diagnostic vitrectomy yielded cellular evidence of adenocarcinoma, with thyroid transcription factor-1 staining confirming a lung primary.
  
  
  CONCLUSIONS
  The perivascular growth of small foci of metastatic vitreous cells suggests vascular co-option from the native retinal circulation. Similar modification of metastatic disease by bevacizumab has been observed in animal models and selected human cases.
authors.forename: Efrem D
authors.initials: ED
authors.lastname: Mandelcorn
authors.forename: Alan G
authors.initials: AG
authors.lastname: Palestine
authors.forename: Sandor
authors.initials: S
authors.lastname: Dubovy
authors.forename: Janet L
authors.initials: JL
authors.lastname: Davis