title: Enhancement of cancer chemosensitization potential of cisplatin by tea polyphenols poly(lactide-co-glycolide) nanoparticles.
abstract: Anti-cancer potential of polymer based nanoparticle of EGCG and TF alone and in combination with anti-cancer drug cisplatin have been studied in human cancer lines: A549 (lung carcinoma), HeLa (cervical carcinoma) and THP-1 (acute monocytic leukemia) using cell proliferation assay and cell cycle analysis. Encapsulated polyphenols retained biological effectiveness with over 20-fold dose advantage than EGCG/TF in exerting anti-cancer effects and also enhanced the potential of a widely used anti-cancer drug cisplatin. Subsequently, encapsulated polyphenols alone or in combination with cisplatin were more effective in inhibiting cell proliferation, metastasis, angiogenesis and apoptosis biomarkers. Collectively, our observations reveal that nanoparticle-mediated delivery of phytochemicals could serve as a basis for enhancing bioavailability and limiting the unwanted toxicity of chemotherapeutic agents.
authors.affiliation: Indian Institute of Toxicology Research, (Council of Scientific and Industrial Research, India), P.O. Box 80, M. G. Marg, Lucknow 226001, India.
authors.forename: Madhulika
authors.initials: M
authors.lastname: Singh
authors.forename: Priyanka
authors.initials: P
authors.lastname: Bhatnagar
authors.forename: Amit K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Pradeep
authors.initials: P
authors.lastname: Kumar
authors.forename: Yogeshwer
authors.initials: Y
authors.lastname: Shukla
authors.forename: Kailash C
authors.initials: KC
authors.lastname: Gupta
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000737:chemistry; D028241:Camellia sinensis / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000737:chemistry; D004357:Drug Synergism; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010636:Phenols / Q000008:administration & dosage / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D059808:Polyphenols; D016896:Treatment Outcome
chemical_list: D005419:Flavonoids; D053769:Nanocapsules; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D002945:Cisplatin