title: Testing for immunomodulatory properties of nanoparticles.
abstract: Immune activation and inflammation can precipitate a variety of diseases. A screening assay for immunomodulatory properties is described. It is based on freshly isolated human peripheral blood mononuclear cells and allows testing for effects of nanoparticles on the human immune system.
authors.affiliation: Division of Biological Chemistry, Biocenter Innsbruck Medical University, 6020 Innsbruck, Austria.
authors.forename: Marcel
authors.initials: M
authors.lastname: Jenny
authors.forename: Sebastian
authors.initials: S
authors.lastname: Schroecksnadel
authors.forename: Dietmar
authors.initials: D
authors.lastname: Fuchs
mesh_terms: D001681:Biological Assay / Q000379:methods*; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology*; D007155:Immunologic Factors / Q000633:toxicity*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008422:Materials Testing / Q000379:methods*; D053758:Nanoparticles / Q000633:toxicity*
chemical_list: D007155:Immunologic Factors