title: [Growth hormone therapy and hypersensitivity type III reaction: a contraindication for desensitization].
abstract: Allergic reactions against GH are rare, and usually represented by the hypersensitivity type I (IgE-mediated). This type of reaction can be treated by desensitization. In this case report, we present a patient showing an allergic reaction soon after starting GH therapy mediated by immune complex (hypersensitivity type III reaction). In this condition, the attempt to perform the desensitization procedure can perpetuate immune complex deposition determining a life threatening renal and respiratory insufficiency.
authors.affiliation: Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.
authors.forename: Wilma Carvalho Neves
authors.initials: WC
authors.lastname: Forte
authors.forename: Cristiane
authors.initials: C
authors.lastname: Kochi
authors.forename: Claudia Dutra Costantin
authors.initials: CD
authors.lastname: Faria
authors.forename: Luis Eduardo Procópio
authors.initials: LE
authors.lastname: Calliari
authors.forename: Osmar
authors.initials: O
authors.lastname: Monte
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Longui
mesh_terms: D000936:Antigen-Antibody Complex / Q000276:immunology; D002648:Child; D000075202:Contraindications; D003888:Desensitization, Immunologic; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000276:immunology*
chemical_list: D000936:Antigen-Antibody Complex; D019382:Human Growth Hormone