title: Effects of reduction mammoplasty on metabolic profile and body weight.
abstract: BACKGROUND
  Advanced studies on adipose tissue have established that subcutaneous adipose tissue acts as an endocrine organ to help maintain homeostasis. Based on this information, many plastic surgeons have evaluated the metabolic effects of liposuction because liposuction is the most common surgical procedure in plastic surgery. Liposuction removes a substantial amount of subcutaneous fat from a specific area of the body. Mammoplasty is another procedure that removes a large amount of subcutaneous fat. In this study, the metabolic effects of reduction mammoplasty were evaluated with hemogram, blood glucose, lipid profile, insulin, and insulin resistance tests before and after surgery.
  
  
  METHODS
  The study involved 35 patients who underwent reduction mammoplasty between January 2006 and June 2009. All the patients were evaluated with physical examination and their history, height, and weight were obtained. Venous blood samples were collected before, 4 h after, and 3 months after the surgical procedure to evaluate hemogram, blood glucose, insulin, and lipid profiles. The HOMA scores of the patients were calculated. Inferiorly based dermal pedicle, central pedicle, and free nipple graft techniques were used in the operations and all excision materials were sent for histopathological examination.
  
  
  RESULTS
  The mean age of the patients was 39.6 ± 11.6 years. The mean excision volume was 2249 ± 1001 g. Body mass indexes were not significantly different before and 3 months after the surgery (p > 0.05). Blood glucose, LDL, HDL, triglyceride, total cholesterol, hemoglobin, and hematocrit values before and 4 h after the surgery were also different (p < 0.05). However, comparisons with the 3-month postoperative test results revealed no statistically significant differences (p > 0.05) and comparisons of all the measurements showed that insulin levels and HOMA scores were not significantly different (p > 0.05).
  
  
  CONCLUSIONS
  The results of the present study showed that reduction mammoplasty operations do not have any positive effects on blood insulin, glucose profile, lipid profile, and body mass index 3 months after the surgery.
authors.affiliation: Plastic Reconstructive and Aesthetic Surgery Department, Bitlis State Hospital, Beş Minare Mahallesi, Bitlis, Turkey. drmuratsarici@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Sarıcı
authors.forename: M Erol
authors.initials: ME
authors.lastname: Demirseren
authors.forename: Mustafa
authors.initials: M
authors.lastname: Durgun
authors.forename: Candemir
authors.initials: C
authors.lastname: Ceran
authors.forename: M Oguz
authors.initials: MO
authors.lastname: Yenidunya
mesh_terms: D000328:Adult; D001786:Blood Glucose; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D016462:Mammaplasty; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol