title: Investigations on the interaction of gold-curcumin nanoparticles with human peripheral blood lymphocytes.
abstract: The use of nano-particles in several areas necessitates the understanding of their interaction with cells, tissues and experimental animals. In the present study, the effect of a curcumin conjugated gold nano-particle on peripheral blood lymphocytes was investigated. The treated lymphocytes revealed features typical of apoptosis which include chromatin condensation, and membrane blebbing and occurrence of apoptotic bodies. The observations indicate that these nanoparticle conjugates may find use as drugs in non-toxic range observed in cytotoxicity studies.
authors.affiliation: Central Leather Research Institute, (Council of Scientific and Industrial Research, India) Adyar, Chennai 600020, India.
authors.forename: K
authors.initials: K
authors.lastname: Sindhu
authors.forename: R
authors.initials: R
authors.lastname: Indra
authors.forename: A
authors.initials: A
authors.lastname: Rajaram
authors.forename: K J
authors.initials: KJ
authors.lastname: Sreeram
authors.forename: Rama
authors.initials: R
authors.lastname: Rajaram
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D006046:Gold / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology* / Q000187:drug effects*; D053769:Nanocapsules / Q000009:adverse effects* / Q000737:chemistry*; D053758:Nanoparticles / Q000009:adverse effects* / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D053769:Nanocapsules; D006046:Gold; D003474:Curcumin