title: Nano-specific genotoxic effects.
abstract: It cannot be generally assumed that nanoparticles are genotoxic or that nanoscale size would increase the genotoxicity of the material. The large-scale in vivo genotoxicity testing of the various nanomaterials does not seem realistic. Information on nanoparticle characteristics associated with genotoxicity, carcinogenicity and mechanisms involved can probably be used in risk assessment.
authors.affiliation: Nanosafety Research Center, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.
authors.forename: Hannu
authors.initials: H
authors.lastname: Norppa
authors.forename: Julia
authors.initials: J
authors.lastname: Catalán
authors.forename: Ghita
authors.initials: G
authors.lastname: Falck
authors.forename: Kati
authors.initials: K
authors.lastname: Hannukainen
authors.forename: Kirsi
authors.initials: K
authors.lastname: Siivola
authors.forename: Kai
authors.initials: K
authors.lastname: Savolainen
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods*; D002468:Cell Physiological Phenomena / Q000187:drug effects*; D006801:Humans; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity*; D049329:Nanostructures / Q000633:toxicity*
chemical_list: D009153:Mutagens