title: Prognostic value of combined magnetic resonance myocardial perfusion imaging and late gadolinium enhancement.
abstract: Late gadolinium enhancement (LGE) and myocardial perfusion study by cardiac magnetic resonance (CMR) have a diagnostic and prognostic value in patients with suspected coronary artery disease (CAD). The purpose of this study was to determine the prognostic value of combined myocardial perfusion CMR and LGE in patients with known or suspected CAD. We studied patients with known or suspected CAD. All patients underwent CMR for functional study, myocardial perfusion and LGE. Myocardial ischemia by CMR was defined as a perfusion defect in patients without LGE or a perfusion defect beyond the LGE area. Patients were followed up for cardiovascular outcomes including hard cardiac events (cardiac death or non-fatal myocardial infarction) and major adverse cardiac events (MACE) which included cardiac death, non-fatal myocardial infarction, hospitalization for unstable angina, and heart failure. There were a total of 587 men and 645 women. Average age was 64.6 ± 11.1 years. LGE was detected in 326 patients (26.5%). Myocardial ischemia by CMR was detected in 423 patients (34.3%). Average follow-up duration was 34.9 ± 15.6 months. Univariate analysis showed that age, diabetes, use of beta blocker, left ventricular ejection fraction, left ventricular mass, wall motion abnormality, LGE, and myocardial ischemia are predictors for hard cardiac events and MACE. Multivariable analysis revealed that myocardial ischemia was the strongest predictor for hard cardiac events and MACE. Other independent predictors were age, use of beta blocker, and left ventricular mass. Myocardial ischemia by CMR has an incremental prognostic value for cardiac events in patients with known or suspected CAD.
authors.affiliation: Division of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sirkt@mahidol.ac.th
authors.forename: Rungroj
authors.initials: R
authors.lastname: Krittayaphong
authors.forename: Vithaya
authors.initials: V
authors.lastname: Chaithiraphan
authors.forename: Adisak
authors.initials: A
authors.lastname: Maneesai
authors.forename: Suthipol
authors.initials: S
authors.lastname: Udompanturak
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000209:etiology; D015906:Angioplasty, Balloon, Coronary; D003287:Contrast Media; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D003326:Coronary Circulation; D005260:Female; D019786:Gadolinium DTPA; D006333:Heart Failure / Q000209:etiology; D006760:Hospitalization; D006801:Humans; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000209:etiology / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011859:Radiography; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000209:etiology; D013785:Thailand; D013997:Time Factors
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA