title: Chemokines in renal injury.
abstract: The main function of chemokines is to guide inflammatory cells in their migration to sites of inflammation. During the last 2 decades, an expanding number of chemokines and their receptors have driven broad inquiry into how inflammatory cells are recruited in a variety of diseases. Although this review focuses on chemokines and their receptors in renal injury, proinflammatory IL-17, TGFβ, and TWEAK signaling pathways also play a critical role in their expression. Recent studies in transgenic mice as well as blockade of chemokine signaling by neutralizing ligands or receptor antagonists now allow direct interrogation of chemokine action. The emerging role of regulatory T cells and Th17 cells during renal injury also forges tight relationships between chemokines and T cell infiltration in the development of kidney disease. As chemokine receptor blockade inches toward clinical use, the field remains an attractive area with potential for unexpected opportunity in the future.
authors.affiliation: Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Arthur C K
authors.initials: AC
authors.lastname: Chung
authors.forename: Hui Y
authors.initials: HY
authors.lastname: Lan
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000276:immunology; D000818:Animals; D018925:Chemokines / Q000235:genetics / Q000502:physiology*; D002908:Chronic Disease; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007674:Kidney Diseases / Q000209:etiology*; D019707:Receptors, Chemokine / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D058504:Th17 Cells / Q000502:physiology
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine