title: Antibacterial activities of macrolactin A and 7-O-succinyl macrolactin A from Bacillus polyfermenticus KJS-2 against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus.
abstract: The principal objective of this study was to evaluate the antibacterial activities of macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA) generated from Bacillus polyfermenticus KJS-2 against vancomycin-resistant enterococci (VREs) and methicillin-resistant Staphylococcus aureus. The minimal inhibitory concentrations (MICs) of MA and SMA against VREs were 16 and 2∼1 μg/mL, respectively, and the MICs of MA and SMA against methicillin-resistant Staphylococcus aureus were 2 and < 0.25 μg/mL, respectively. Their MIC values were comparable or superior to those of teicoplanin. In evaluating the inhibitory effects of intestinal VRE colonization in mice, the oral MA and SMA effected a rapid inhibition of intestinal VRE colonization in mice, and the intraperitoneal SMA also inhibited VRE colonization, whereas intraperitoneal MA did not.
authors.affiliation: Research and Development Center, Daewoo Pharm. Co. Ltd., Gimhae, Korea.
authors.forename: Dong Hee
authors.initials: DH
authors.lastname: Kim
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Kang Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Chun Kyu
authors.initials: CK
authors.lastname: Kim
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Jeong
authors.forename: Chan Young
authors.initials: CY
authors.lastname: Ko
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Moon
authors.forename: Jae Seon
authors.initials: JS
authors.lastname: Kang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001407:Bacillus / Q000378:metabolism*; D016983:Enterococcus / Q000187:drug effects; D005260:Female; D007422:Intestines / Q000382:microbiology; D018942:Macrolides / Q000302:isolation & purification / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D017334:Teicoplanin / Q000494:pharmacology; D020713:Vancomycin Resistance
chemical_list: C559723:7-O-succinyl macrolactin A; D000900:Anti-Bacterial Agents; D018942:Macrolides; C453562:macrolactin A; D017334:Teicoplanin