title: Genes associated with epithelial-mesenchymal transition: possible therapeutic targets in ductal pancreatic adenocarcinoma?
abstract: Epithelial to mesenchymal transition (EMT) is a biological process that allows well-differentiated, polarized epithelial cells to undergo a conversion to motile, unpolarized mesenchymal cells. EMT plays crucial roles during implantation, embryogenesis, and organ development (Type 1 EMT), is associated with tissue regeneration and organ fibrosis (Type 2 EMT), and involved in cancer invasion, metastasis, and drug resistance (Type 3 EMT). Since aggressiveness and drug resistance are hallmarks of ductal pancreatic cancer, significant effort has been undertaken in recent years to elucidate molecular EMT mechanisms in this dismal malignancy. This represents a formidable challenge for several reasons: EMT is a dynamic process, both with regard to spatial and temporal heterogeneity. Moreover, EMT is induced and regulated by a complex network of traditional signaling pathways and new players like microRNAs. Interestingly, similar molecular characteristics link EMT-type cells also to the concept of cancer stem cells. This review tries to integrate the current knowledge regarding EMT and pancreatic cancer; furthermore to outline not only the perspective on novel EMT-associated therapeutic targets, but also on overcoming drug resistance by interfering with EMT.
authors.affiliation: Department of Surgery I, Charité School of Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany. hubert.hotz@charite.de
authors.forename: Hubert G
authors.initials: HG
authors.lastname: Hotz
authors.forename: Birgit
authors.initials: B
authors.lastname: Hotz
authors.forename: Heinz-Johannes
authors.initials: HJ
authors.lastname: Buhr
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy*; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000627:therapeutic use; D058990:Molecular Targeted Therapy / Q000379:methods*; D014411:Neoplastic Stem Cells / Q000473:pathology
chemical_list: D035683:MicroRNAs