title: Bio-functionalisation of polydimethylsiloxane with hyaluronic acid and hyaluronic acid--collagen conjugate for neural interfacing.
abstract: In this work, polydimethylsiloxane was activated with oxygen plasma and treated with silanes bearing ethylene imine units. Hyaluronic acid was then grafted covalently onto the aminated surfaces. The influence of silane structure on surface amination was assessed and the influence of the modification on surface physiochemical properties and protein adsorption of modified polydimethylsiloxane were investigated. Collagen type I was conjugated onto the modified polydimethylsiloxane to improve its cyto-compatibility for neural applications. In vitro cultivation of rat pheochromocytoma cells on the bioactive polydimethylsiloxane showed a significant increase in cell growth and differentiation. The potential applications of the bio-functionalized polydimethylsiloxane in cochlear implant electrode arrays were discussed.
authors.affiliation: ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM facility, University of Wollongong, NSW 2522, Australia; The HEARing CRC, Carlton, Australia.
authors.forename: Zhilian
authors.initials: Z
authors.lastname: Yue
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Molino
authors.forename: Gordon G
authors.initials: GG
authors.lastname: Wallace
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003054:Cochlear Implants; D003094:Collagen / Q000737:chemistry*; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D016716:PC12 Cells; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D004129:Dimethylpolysiloxanes; C013830:baysilon; D006820:Hyaluronic Acid; D003094:Collagen