title: Radiation-sensitive diselenide block co-polymer micellar aggregates: toward the combination of radiotherapy and chemotherapy.
abstract: We have developed a potential radiation-sensitive drug-delivery system using active diselenide-containing block co-polymer aggregates in aqueous solution that can load and release anticancer drugs. These aggregates were sensitive to even a low dose of γ-radiation, such as 5 Gy, which is close to the radiation dose received by patients during a single radiotherapy treatment. This line of research may open an avenue for the combination of radiotherapy and chemotherapy.
authors.affiliation: Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.forename: Huaping
authors.initials: H
authors.lastname: Xu
authors.forename: Liping
authors.initials: L
authors.lastname: An
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Sun
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D005720:Gamma Rays; D056945:Hep G2 Cells; D006801:Humans; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D018036:Selenium Compounds / Q000737:chemistry* / Q000633:toxicity; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D018036:Selenium Compounds; D014867:Water; D011092:Polyethylene Glycols