title: Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients.
abstract: The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes.
authors.affiliation: Center for Melanoma Research and Treatment, Department of Surgery, California Pacific Medical and Research Institute, San Francisco, California 94115, USA. leongsx@cpmcri.org
authors.forename: Stanley P L
authors.initials: SP
authors.lastname: Leong
authors.forename: Markus
authors.initials: M
authors.lastname: Zuber
authors.forename: Robert L
authors.initials: RL
authors.lastname: Ferris
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Ramon
authors.initials: R
authors.lastname: Cabanas
authors.forename: Charles
authors.initials: C
authors.lastname: Levenback
authors.forename: Mark
authors.initials: M
authors.lastname: Faries
authors.forename: Sukamal
authors.initials: S
authors.lastname: Saha
mesh_terms: D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*; D011379:Prognosis; D021701:Sentinel Lymph Node Biopsy; D047368:Tumor Burden