title: Caveolin-1 in sarcomas: friend or foe?
abstract: Sarcomas represent a heterogeneous group of tumors with a complex and difficult reproducible classification. Their pathogenesis is poorly understood and there are few effective treatment options for advanced disease. Caveolin-1 is a multifunctional scaffolding protein with multiple binding partners that regulates multiple cancer-associated processes including cellular transformation, tumor growth, cell death and survival, multidrug resistance, angiogenesis, cell migration and metastasis. However, ambiguous roles have been ascribed to caveolin-1 in signal transduction and cancer, including sarcomas. In particular, evidence indicating that caveolin-1 function is cell context dependent has been repeatedly reported. Caveolin-1 appears to act as a tumor suppressor protein at early stages of cancer progression. In contrast, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. This review is focused on the role of caveolin-1 in several soft tissue and bone sarcomas and discusses the use of this protein as a potential diagnostic and prognostic marker and as a therapeutic target.
authors.affiliation: Sarcoma Research Group, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Sáinz-Jaspeado
authors.forename: Juan
authors.initials: J
authors.lastname: Martin-Liberal
authors.forename: Laura
authors.initials: L
authors.lastname: Lagares-Tena
authors.forename: Silvia
authors.initials: S
authors.lastname: Mateo-Lozano
authors.forename: Xavier
authors.initials: X
authors.lastname: Garcia del Muro
authors.forename: Oscar M
authors.initials: OM
authors.lastname: Tirado
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D001859:Bone Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000473:pathology; D051242:Caveolin 1 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D012509:Sarcoma / Q000175:diagnosis* / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D051242:Caveolin 1