title: Oral eosinophilic ulcer, an Epstein-Barr virus-associated CD30+ lymphoproliferation?
abstract: Eosinophilic ulcer of the oral mucosa is a benign lesion of unclear pathogenesis mostly affecting the tongue. It has been suggested to represent a reactive pattern to several stimuli. We report on a 12-year-old boy who presented with a painless infiltrating ulcer on the gingiva of the lower jaw, which was covered by necrotic yellowish slough. There were no pathologic features of the jawbones or regional lymph nodes. Histopathological, immunohistochemical and gene rearrangement studies were in agreement with eosinophilic ulcer with predominant oligoclonal CD3+ and CD30+ T lymphocytes expressing the Epstein-Barr virus membrane protein. The ulcer resolved within 4 weeks and follow-up for 3 years revealed no evidence of recurrence. Epstein-Barr virus may have played a role in triggering this reactive lymphoproliferative disorder.
authors.affiliation: Department of Dermatology, Dessau Medical Center, Dessau, Germany.
authors.forename: M B
authors.initials: MB
authors.lastname: Abdel-Naser
authors.forename: F
authors.initials: F
authors.lastname: Tsatsou
authors.forename: S
authors.initials: S
authors.lastname: Hippe
authors.forename: J
authors.initials: J
authors.lastname: Knolle
authors.forename: I
authors.initials: I
authors.lastname: Anagnostopoulos
authors.forename: H
authors.initials: H
authors.lastname: Stein
authors.forename: C C
authors.initials: CC
authors.lastname: Zouboulis
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017252:CD3 Complex / Q000276:immunology; D002648:Child; D004802:Eosinophilia / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000821:virology*; D004803:Eosinophilic Granuloma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000821:virology*; D005882:Gingival Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000821:virology*; D006801:Humans; D017730:Ki-1 Antigen / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000821:virology*; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use; D019226:Oral Ulcer / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000821:virology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000821:virology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017252:CD3 Complex; D017730:Ki-1 Antigen; D009067:Mouthwashes