title: Molecular and clinical characteristics of hemoglobin Ottawa detected in a Chinese population.
abstract: Hemoglobin (Hb) Ottawa [α15 (A13) Gly→Arg], also known as Hb Siam, was first described in an 82-year-old Canadian in 1974. The same year, a second case was reported in a 28-year-old Chinese male living in Thailand. A third case was found in 1986 in a Chinese female living in the Hubei province of China. Since then, there have been no reports of Hb Ottawa in mainland China in the English literature. Hb Ottawa results from a GGT→CGT mutation in codon 15 of the α1 or α2-globin gene. Hb Ottawa carriers do not present any clinical symptoms or hematological changes, and are often diagnosed during a health examination and thalassemia screening. In a hemoglobin survey of 9745 students in Chaozhou, Guangdong, China, we identified four cases of Hb Ottawa in a thalassemia screening by Hb electrophoresis, and confirmed it to be the result of a GGT→CGT mutation in codon 15 of the α2-globin gene by DNA sequence analysis.
authors.affiliation: Department of Central Laboratory, Chaozhou Central Hospital, Chaozhou, Guangdong 521021, PR China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
authors.forename: Min
authors.initials: M
authors.lastname: Lin
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Lin
authors.forename: Jiao-Ren
authors.initials: JR
authors.lastname: Wu
authors.forename: Luo-Han
authors.initials: LH
authors.lastname: Zheng
authors.forename: Li-Ye
authors.initials: LY
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002648:Child; D002681:China; D005260:Female; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D006455:Hemoglobins, Abnormal; C406708:hemoglobin Siam