title: Electrocatalytic determination of sumatriptan on the surface of carbon-paste electrode modified with a composite of cobalt/Schiff-base complex and carbon nanotube.
abstract: The electrochemical oxidation of sumatriptan on the surface of carbon paste electrode modified with multi-walled carbon nanotube and cobalt methyl-salophen complex is studied by using cyclic voltammetry and polarization studies. The results indicate that the drug is irreversibly oxidized in a one electron oxidation mechanism. It was found that the peak potential shifted negatively with increasing pH, confirms that H(+) participate in the oxidation process. The electrode is shown to be very effective for the detection of sumatriptan in the presence of other biological reductant compounds. The prepared modified electrode exhibits a very good resolution between the voltammetric peaks of sumatriptan, ascorbic acid and uric acid, which makes it suitable for the simultaneous detection of sumatriptan in the presence of these compounds in clinical and pharmaceutical preparations. It can be concluded that multi-walled carbon nanotube and Shiff base complex have synergic effect on electroacatalytic oxidation of sumatriptan. A linear range of 1-1000μM and detection limit of 0.3μM was obtained for sumatriptan from DPV measurements using this electrode in 0.1M acetate buffered solution of pH 5.0. The electrode has been applied successfully for the determination of sumatriptan in synthetic serum and commercial tablets.
authors.affiliation: Department of Chemistry, Payame Noor University, Ardabil, Iran. m_amiri@pnu.ac.ir
authors.forename: Mandana
authors.initials: M
authors.lastname: Amiri
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Pakdel
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Bezaatpour
authors.forename: Saeed
authors.initials: S
authors.lastname: Shahrokhian
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D011048:Polarography / Q000379:methods*; D011199:Potentiometry / Q000379:methods; D012545:Schiff Bases / Q000737:chemistry; D018170:Sumatriptan / Q000032:analysis* / Q000737:chemistry*; D013607:Tablets / Q000032:analysis / Q000737:chemistry; D014527:Uric Acid / Q000737:chemistry
chemical_list: D037742:Nanotubes, Carbon; D012545:Schiff Bases; D013607:Tablets; D014527:Uric Acid; D003035:Cobalt; D018170:Sumatriptan; D001205:Ascorbic Acid