title: Reversal of thrombocytopenia and bleeding tendency in a preterm neonate with recombinant activated factor VII: case report.
abstract: A male neonate, born at 26 weeks of postmenstrual age, with intracranial hemorrhage grade IV and thoracic drainage for artificial tension pneumothorax on day 6 of his life is presented. Despite prior transfusions, the preprocedural hemogram showed marked anemia and thrombocytopenia. To reverse thrombocytopenia and to avoid volume overload, the patient was administered 110 microg kg(-1) of recombinant activated factor VII (rFVIIa) and drainage of the pneumothorax was performed uneventfully.
authors.affiliation: Department of Anesthesiology, Resuscitation and Intensive Therapy, Zagreb Children's Hospital, Zagreb, Croatia. jjakobov@inet.hr
authors.forename: Jasminka
authors.initials: J
authors.lastname: Jakobović
authors.forename: Diana
authors.initials: D
authors.lastname: Butković
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Popović
authors.forename: Dubravka
authors.initials: D
authors.lastname: Bartolek
authors.forename: Milan
authors.initials: M
authors.lastname: Stanojević
authors.forename: Zoran
authors.initials: Z
authors.lastname: Barcot
mesh_terms: D015942:Factor VIIa / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000188:drug therapy*; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000097:blood / Q000188:drug therapy*
chemical_list: D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa