title: Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation.
abstract: Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-κB-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.
authors.affiliation: Department of Pharmaceutical Gene Modulation, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan, The Netherlands.
authors.forename: Massimo
authors.initials: M
authors.lastname: Ghizzoni
authors.forename: Hidde J
authors.initials: HJ
authors.lastname: Haisma
authors.forename: Harm
authors.initials: H
authors.lastname: Maarsingh
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Dekker
mesh_terms: D000107:Acetylation; D000818:Animals; D051548:Histone Acetyltransferases / Q000037:antagonists & inhibitors*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000201:enzymology* / Q000276:immunology; D016328:NF-kappa B / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D054852:Small Molecule Libraries / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D016328:NF-kappa B; D054852:Small Molecule Libraries; D051548:Histone Acetyltransferases