title: Cholesteryl ester transfer protein: the controversial relation to atherosclerosis and emerging new biological roles.
abstract: Cholesteryl ester transfer protein (CETP) exerts a profound impact on high-density lipoprotein (HDL) metabolism and, consequently, on the risk of atherosclerosis development and cardiovascular mortality. Here, we review the complex relationship between CETP and atherosclerosis based upon the experimental, clinical, and epidemiological studies. In addition, we discuss the recent findings that expand the functions of CETP to new areas of interest such as Alzheimer's disease, inflammation, and obesity.
authors.affiliation: Department of Physiology and Biophysics, State University of Campinas, Campinas, SP, Brazil. ho98@unicamp.br
authors.forename: Helena C F
authors.initials: HC
authors.lastname: Oliveira
authors.forename: Eliana C
authors.initials: EC
authors.lastname: de Faria
mesh_terms: D050156:Adipogenesis; D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D002986:Clinical Trials as Topic; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D009154:Mutation; D009765:Obesity / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D053480:Cholesterol Ester Transfer Proteins; D008074:Lipoproteins; D002784:Cholesterol