title: Lack of association between ORAI1/CRACM1 gene polymorphisms and Kawasaki disease in the Taiwanese children.
abstract: OBJECTIVE
  Kawasaki disease (KD) is characterized by systemic vasculitis of an unknown cause. A previous study has indicated that a polymorphism of the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene is involved in the susceptibility to KD. ORAI (also known as CRACM1) is one of the components of store-operated calcium channels involved in regulating immune and inflammatory reactions. This study was conducted to investigate if polymorphisms in ORAI1/CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes.
  
  
  METHODS
  A total of 1,056 subjects (341 KD patients and 715 controls) were investigated to identify five tagging single nucleotide polymorphisms (tSNPs) in ORAI1/CRACM1 (rs12313273, rs6486795, rs7135617, rs12320939, and rs712853) by using the TaqMan Allelic Discrimination assay.
  
  
  RESULTS
  No significant associations between genotype and allele frequency of the five ORAI1/CRACM1 tSNPs were observed in the KD patients and controls. In KD patients, no significant associations between ORAI1/CRACM1 polymorphisms and coronary artery lesion (CAL) formation or intravenous immunoglobulin (IVIG) treatment response were observed. The results from haplotype analysis were insignificant.
  
  
  CONCLUSIONS
  This study showed for the first time that ORAI1/CRACM1 polymorphisms are not associated with KD susceptibility, CAL formation, or IVIG treatment response in the Taiwanese population.
authors.affiliation: Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.
authors.forename: Ho-Chang
authors.initials: HC
authors.lastname: Kuo
authors.forename: Ying-Jui
authors.initials: YJ
authors.lastname: Lin
authors.forename: Suh-Hang Hank
authors.initials: SH
authors.lastname: Juo
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Hsu
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chen
authors.forename: Kuender D
authors.initials: KD
authors.lastname: Yang
authors.forename: Chi-Di
authors.initials: CD
authors.lastname: Liang
authors.forename: Shengyu
authors.initials: S
authors.lastname: Yang
authors.forename: Mei-Chyn
authors.initials: MC
authors.lastname: Chao
authors.forename: Hong-Ren
authors.initials: HR
authors.lastname: Yu
authors.forename: Shouyan
authors.initials: S
authors.lastname: Wang
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Lin
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chang
mesh_terms: D015220:Calcium Channels / Q000097:blood / Q000235:genetics*; D002648:Child; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D000071740:ORAI1 Protein; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan
chemical_list: D015220:Calcium Channels; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; D017853:Phosphotransferases (Alcohol Group Acceptor); C051038:Inositol 1,4,5-trisphosphate 3-kinase