title: New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn.
abstract: Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (1- 2) and four known (3- 6) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity.
authors.affiliation: Department of Chemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Lang
authors.forename: Tatiana
authors.initials: T
authors.lastname: da Rosa Guimarães
authors.forename: Vanessa
authors.initials: V
authors.lastname: Rocha Machado
authors.forename: Lara A
authors.initials: LA
authors.lastname: Zimmermann
authors.forename: Izabella T
authors.initials: IT
authors.lastname: Silva
authors.forename: Marina R
authors.initials: MR
authors.lastname: Teixeira
authors.forename: Fernando J
authors.initials: FJ
authors.lastname: Durán
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Palermo
authors.forename: Cláudia M O
authors.initials: CM
authors.lastname: Simões
authors.forename: Miguel S B
authors.initials: MS
authors.lastname: Caro
authors.forename: Eloir P
authors.initials: EP
authors.lastname: Schenkel
mesh_terms: D001938:Brazil; D045744:Cell Line, Tumor; D002470:Cell Survival; D002851:Chromatography, High Pressure Liquid; D019662:Cucurbitaceae / Q000737:chemistry*; D054728:Cucurbitacins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008519:Medicine, Traditional; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D010936:Plant Extracts; D054728:Cucurbitacins