title: Amyotrophic lateral sclerosis is associated with hypolipidemia at the presymptomatic stage in mice.
abstract: OBJECTIVE
  To demonstrate that hypolipidemia is a typical feature of the mouse model of amyotrophic lateral sclerosis (ALS) and to assess the association between hypolipidemia and disease stage, dietary intake, and sex.
  
  
  METHODS
  We compared daily dietary intake, body weight, and serumlipid and glucose levels in ALS mice and wild-type controls at different stages of the disease.
  
  
  RESULTS
  Total cholesterol low-density lipoprotein (LDL) and LDL/high-density lipoprotein (HDL) ratio were significantly lower in ALS mice compared with controls. Subgroup analysis revealed that the incidence of hypolipidemia was significantly greater in male, but not female, ALS mice compared with control mice and that hypolipidemia was present at the presymptomatic stage of the disease. This hypolipidemia can be found without a decrease in the serum levels of other energy sources, such as glucose, in the presymptomatic stage.
  
  
  CONCLUSIONS
  Hypolipidemia is present at the presymptomatic stage of the ALS mouse model in the absence of malnutrition, significant neuromuscular degeneration or regeneration, and respiratory difficulty. Our findings suggest that hypolipidemia might be associated with the pathomechanism of ALS and/or lipid-specific metabolism rather than simply an epiphenomenon of neuromuscular degeneration or energy imbalance.
authors.affiliation: Department of Neurology, College of Medicine, Seoul National University, Seoul, Korea.
authors.forename: Sung-Min
authors.initials: SM
authors.lastname: Kim
authors.forename: Heejaung
authors.initials: H
authors.lastname: Kim
authors.forename: Jee-Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Kyung Seok
authors.initials: KS
authors.lastname: Park
authors.forename: Jung-Joon
authors.initials: JJ
authors.lastname: Sung
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Kwang-Woo
authors.initials: KW
authors.lastname: Lee
mesh_terms: D000375:Aging / Q000473:pathology; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood / Q000150:complications*; D000818:Animals; D058070:Asymptomatic Diseases; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007009:Hypolipoproteinemias / Q000097:blood / Q000150:complications*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D012727:Sex Characteristics
chemical_list: D001786:Blood Glucose; D008077:Lipoproteins, LDL; D002784:Cholesterol