title: Acute renal failure SNAPPE and mortality.
abstract: BACKGROUND
  The aim of the present study was to determine, using the score for neonatal acute physiology and perinatal extension II (SNAPPE-II), whether there is an association with acute renal failure (ARF) and whether it is possible to identify newborns at risk for ARF prior to a rise in creatinine in newborns.
  
  
  METHODS
  Information on postnatal risk factors and SNAPPE-II on the first day of life (non-ARF group, n= 475; ARF group, n= 78) were collected. Renal failure was defined as serum creatinine level >1 mg/dL and >1.3 mg/dL (for ≥ 33 weeks and < 33 weeks, respectively) after 48 h of life.
  
  
  RESULTS
  In newborns with ARF (n= 78), the median (range) of SNAPPE-II and mortality rate were significantly higher than those of the control group. Patent ductus arteriosus (PDA), disseminated intravascular coagulation (DIC), SNAPPE-II, and resuscitation were identified as independent predictors of ARF in infants on forward stepwise logistic regression. Sepsis, respiratory distress syndrome, ARF, DIC, and SNAPPE-II were identified as independent predictors of mortality in infants on the same analysis.
  
  
  CONCLUSIONS
  SNAPPE-II on the first day of life was significantly higher among babies with ARF, suggesting a positive association between higher scores and the development of ARF and mortality, but based on receiver operating characteristic curve results, SNAPPE-II at admission did not enhance the assessment of risk for ARF prior to a rise in creatinine.
authors.affiliation: Neonatology Division, Medical Faculty, Kocaeli University, Kocaeli, Turkey. gulcanturker@kocaeli.edu.tr
authors.forename: Gülcan
authors.initials: G
authors.lastname: Türker
authors.forename: Gamze
authors.initials: G
authors.lastname: Ozsoy
authors.forename: Ayla
authors.initials: A
authors.lastname: Günlemez
authors.forename: Ayşe S
authors.initials: AS
authors.lastname: Gökalp
authors.forename: Ayşe E
authors.initials: AE
authors.lastname: Arisoy
authors.forename: Zelal
authors.initials: Z
authors.lastname: Bircan
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000175:diagnosis / Q000401:mortality*; D003404:Creatinine / Q000097:blood; D004374:Ductus Arteriosus, Patent / Q000150:complications; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D003404:Creatinine