title: Exploiting sequence to control the hydrolysis behavior of biodegradable PLGA copolymers.
abstract: Monomer sequence is a potentially powerful but underutilized tool for the control of copolymer properties. Sequence is demonstrated to dramatically affect the hydrolysis profile for the degradation of poly(lactic-co-glycolic acid) (PLGA), a member of the most widely used class of biodegradable polymers employed in biomedical applications. The nearly linear molecular weight loss profile and uniform thermal behavior throughout the course of the hydrolysis differ dramatically from the behavior that is exhibited by random copolymer controls with the same comonomer ratio.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Stayshich
authors.forename: Tara Y
authors.initials: TY
authors.lastname: Meyer
mesh_terms: D001673:Biodegradation, Environmental; D006358:Hot Temperature; D006868:Hydrolysis; D019344:Lactic Acid / Q000737:chemistry*; D015394:Molecular Structure; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid