title: [A case of liver nocardiosis associated with Crohn's disease while treating infliximab].
abstract: A 23-year-old man, complaining of chronic diarrhea, was given a diagnosis of Crohn's disease. He responded well to steroid therapy and infliximab administration. However, high fever appeared on the 28th day of hospitalization, and CT scan revealed multiple liver abscesses. Gram-positive branched rods were harvested by ultrasonography guided puncture examination. As Nocardia infection was suspected, sulfamethoxazole-trimethoprim was started immediately, and his clinical course improved dramatically. Afterwards, Nocardia farcinica was isolated from the culture of the liver abscess. This case is the first report of liver nocardiosis associated with Crohn's disease. Generally, Nocardia infection can be successfully treated by sulfamethoxazole-trimethoprim therapy. Liver nocardiosis is very rare but could be an important complication for patients with Crohn's disease.
authors.affiliation: Department of Gastroenterology and Hepatology, Hiroshima General Hospital.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakahara
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kan
authors.forename: Haruna
authors.initials: H
authors.lastname: Nakahara
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Asamoto
authors.forename: Hironao
authors.initials: H
authors.lastname: Komatsu
authors.forename: Hironori
authors.initials: H
authors.lastname: Tokumo
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishida
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D000069285:Infliximab; D008100:Liver Abscess / Q000209:etiology*; D008297:Male; D009617:Nocardia Infections / Q000209:etiology; D009894:Opportunistic Infections / Q000209:etiology; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D000069285:Infliximab