title: Gastroptosis is associated with less dyspepsia, rather than a cause of dyspepsia, in Japanese persons.
abstract: OBJECTIVE
  Gastroptosis is recognized by its characteristic appearance on barium studies. The present prospective study assessed the relationship between gastroptosis and dyspeptic symptoms.
  
  
  METHODS
  Japanese subjects underwent health screening, and gastroptosis was diagnosed by barium studies. Consecutive subjects (500 women and 167 men) with gastroptosis were identified and the same number of age-matched subjects without gastroptosis were selected as controls. Dyspepsia was classified as reflux-like (heartburn and belching), dysmotility-like (bloating and fullness), or ulcer-like dyspepsia (epigastralgia) based on the Rome II criteria.
  
  
  RESULTS
  Body mass index was significantly lower in women with gastroptosis than in controls [19.7 ± 1.83 (SD) vs. 23.4 ± 3.70, p<0.0001], and also in men (19.7 ± 2.00 vs. 23.9 ± 2.89, p<0.0001). The incidence of dyspepsia was significantly lower in women with gastroptosis than in controls (56/500 vs. 87/500, p<0.01) and also in men (10/167 vs. 25/167, p<0.05), especially in women with ulcer-like dyspepsia (15/500 vs. 32/500, p<0.05) and in men with reflux-like dyspepsia (2/167 vs. 12/167, p<0.05). By logistic regression analysis, gastroptosis was associated with a lower risk of dyspepsia (odds ratio: 0.62, 95% CI: 0.405-0.941, p=0.025) and ulcer-like dyspepsia (odds ratio: 0.36, 95% CI: 0.177-0.726, p=0.004) in women.
  
  
  CONCLUSIONS
  Dyspeptic symptoms were significantly less common in subjects with gastroptosis. Accordingly, gastroptosis may protect against dyspeptic symptoms, rather than causing functional dyspepsia.
authors.affiliation: Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Japan. mkusano@showa.gunma-u.ac.jp
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Kusano
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Moki
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hosaka
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shimoyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Kawamura
authors.forename: Atsuto
authors.initials: A
authors.lastname: Nagoshi
authors.forename: Masaki
authors.initials: M
authors.lastname: Maeda
authors.forename: Shikou
authors.initials: S
authors.lastname: Kuribayashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Zai
authors.forename: Masafumi
authors.initials: M
authors.lastname: Mizuide
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Horikoshi
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
authors.forename: Masako
authors.initials: M
authors.lastname: Akuzawa
mesh_terms: D000328:Adult; D001466:Barium Sulfate; D015992:Body Mass Index; D016022:Case-Control Studies; D004415:Dyspepsia / Q000453:epidemiology* / Q000208:ethnology / Q000209:etiology*; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011859:Radiography; D012307:Risk Factors; D013270:Stomach / Q000002:abnormalities* / Q000000981:diagnostic imaging
chemical_list: D001466:Barium Sulfate