title: [Correlation between serum thyroid hormone and dopamine levels and Chinese medicine syndrome types].
abstract: OBJECTIVE
  To analyze the correlation between changes of thyroid hormone (TH), dopamine (DA) and Chinese medicine syndrome types by detecting contents of serum TH and DA in insomnia, thus to explore objective indices of Chinese medicine syndrome types.
  
  
  METHODS
  Insomnia patients were assigned to four Chinese medicine syndrome types groups, covering depressed Gan transforming into fire, internal disturbance by phlegm-heat, excessive fire due to yin deficiency, and Xin-Pi deficiency. One healthy control group was set up. Each group consisted of 30 patients or subjects. Serum DA content was determined using spectrophotofluorometry. Serum levels of 3,5,3'-triiodothyronine (T3) and tetraiodothyronine (T4) were detected using radioimmunoassay (RIA).
  
  
  RESULTS
  The serum levels of DA and TH showed difference among groups at various levels. The serum DA level was sequenced from high to low as the control group > the depressed Gan transforming into fire group > the excessive fire due to yin deficiency group > the internal disturbance by phlegm-heat group > the Xin-Pi deficiency group. The serum TH level was sequenced from high to low as the excessive fire due to yin deficiency group > the depressed Gan transforming into fire group > the internal disturbance by phlegm-heat group > the control group > the Xin-Pi deficiency group.
  
  
  CONCLUSIONS
  Serum DA levels in insomnia patients were in line with the disease course and the dynamic change from sthenia to asthenia in Chinese syndrome types. Serum DA levels, as one of pathological factors constituting the sthenia syndrome or the asthenia syndrome, may be taken as an objective indicator in Chinese medicine syndrome typing.
authors.affiliation: Fujian Institute of Chinese Medicine, Fuzhou. hjsh0825@163.com
authors.forename: Jun-shan
authors.initials: JS
authors.lastname: Huang
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: Fan
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D004298:Dopamine / Q000097:blood*; D006801:Humans; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D007319:Sleep Initiation and Maintenance Disorders / Q000097:blood* / Q000175:diagnosis*; D013963:Thyroid Hormones / Q000097:blood*; D016711:Yang Deficiency / Q000175:diagnosis; D016710:Yin Deficiency / Q000175:diagnosis; D055815:Young Adult
chemical_list: D013963:Thyroid Hormones; D004298:Dopamine