title: Amplified protein detection through visible plasmon shifts in gold nanocrystal solutions from bacteriophage platforms.
abstract: A new method to engineer unique, solution-based protein diagnostics with femotomole sensitivies from modified bacteriophage is reported. These sensors are highly facile to use, rapid to run, possible to read without any spectroscopic or microscopic analysis, and do not require thermally unstable enzymes. These sensing platforms should be functional in locations with limited access to equipment and facilities.
authors.affiliation: Department of Nanoengineering and Engineering Program, University of California, San Diego, La Jolla, 92093-0448, United States.
authors.forename: Ju Hun
authors.initials: JH
authors.lastname: Lee
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Cha
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens / Q000276:immunology; D017104:Bacteriophage M13 / Q000235:genetics* / Q000276:immunology; D015374:Biosensing Techniques / Q000379:methods*; D005818:Genetic Engineering / Q000379:methods*; D006046:Gold / Q000737:chemistry*; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D011506:Proteins / Q000032:analysis* / Q000737:chemistry; D012996:Solutions; D013997:Time Factors
chemical_list: D000941:Antigens; D011506:Proteins; D012996:Solutions; D006046:Gold