title: Early organ-specific mitochondrial dysfunction of jejunum and lung found in rats with experimental acute pancreatitis.
abstract: BACKGROUND
  Multiple organ dysfunction is the main cause of death in severe acute pancreatitis. Primary mitochondrial dysfunction plays a central role in the development and progression of organ failure in critical illness. The present study investigated mitochondrial function in seven tissues during early experimental acute pancreatitis.
  
  
  METHODS
  Twenty-eight male Wistar rats (463 ± 2 g; mean ± SEM) were studied. Group 1 (n= 8), saline control; Group 2 (n= 6), caerulein-induced mild acute pancreatitis; Group 3 (n= 7) sham surgical controls; and Group 4 (n= 7), taurocholate-induced severe acute pancreatitis. Animals were euthanased at 6 h from the induction of acute pancreatitis and mitochondrial function was assessed in the heart, lung, liver, kidney, pancreas, duodenum and jejunum by mitochondrial respirometry.
  
  
  RESULTS
  Significant early mitochondrial dysfunction was present in the pancreas, lung and jejunum in both models of acute pancreatitis, however, the Heart, liver, kidney and duodenal mitochondria were unaffected.
  
  
  CONCLUSIONS
  The present study provides the first description of early organ-selective mitochondrial dysfunction in the lung and jejunum during acute pancreatitis. Research is now needed to identify the underlying pathophysiology behind the organ selective mitochondrial dysfunction, and the potential benefits of early mitochondrial-specific therapies in acute pancreatitis.
authors.affiliation: Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: Anubhav
authors.initials: A
authors.lastname: Mittal
authors.forename: Anthony J R
authors.initials: AJ
authors.lastname: Hickey
authors.forename: Chau C
authors.initials: CC
authors.lastname: Chai
authors.forename: Benjamin P T
authors.initials: BP
authors.lastname: Loveday
authors.forename: Nichola
authors.initials: N
authors.lastname: Thompson
authors.forename: Anna
authors.initials: A
authors.lastname: Dare
authors.forename: Brett
authors.initials: B
authors.lastname: Delahunt
authors.forename: Garth J S
authors.initials: GJ
authors.lastname: Cooper
authors.forename: John A
authors.initials: JA
authors.lastname: Windsor
authors.forename: Anthony R J
authors.initials: AR
authors.lastname: Phillips
mesh_terms: D000208:Acute Disease; D000818:Animals; D015415:Biomarkers / Q000097:blood; D019069:Cell Respiration; D002108:Ceruletide; D004195:Disease Models, Animal; D004734:Energy Metabolism; D007583:Jejunum / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000209:etiology* / Q000378:metabolism; D009102:Multiple Organ Failure / Q000209:etiology* / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism*; D010195:Pancreatitis / Q000139:chemically induced / Q000150:complications* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013656:Taurocholic Acid; D013997:Time Factors
chemical_list: D015415:Biomarkers; D013656:Taurocholic Acid; D002108:Ceruletide