title: [Safety of daptomycin in patients with renal impairment].
abstract: Daptomycin is a lipopeptide bactericidal antimicrobial indicated in the treatment of skin and soft tissue infections (SSTI), Staphylococcus aureus-related right-sided infective endocarditis (RIE) and bacteremia secondary to these infections. The recommended dosage in patients with previous renal impairment is 4 mg/kg/48 hours in SSTI. There are no data published for SSTI and RIE followed by bacteremia. Based on pharmacokinetic models, the recommended dosage in patients under hemodialysis is 4 mg/kg after dialysis. The present article aims to review of the latest published data on daptomycin use in patients with renal impairment and to relate these findings to preliminary data from the EUCORE registry in Spain.
authors.affiliation: Servicio de Farmacología Clínica, Clínica Universidad de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, España. jrazanza@unav.es
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Azanza
authors.forename: Emilio G
authors.initials: EG
authors.lastname: Quetglas
mesh_terms: D000368:Aged; D000617:Aminoglycosides / Q000009:adverse effects / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy; D017576:Daptomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D016208:Databases, Factual / Q000706:statistics & numerical data; D004697:Endocarditis, Bacterial / Q000150:complications / Q000188:drug therapy; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008657:Metabolic Clearance Rate; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data; D009135:Muscular Diseases / Q000139:chemically induced; D010530:Peritoneal Dialysis; D012042:Registries / Q000706:statistics & numerical data; D006435:Renal Dialysis; D012189:Retrospective Studies; D018461:Soft Tissue Infections / Q000150:complications / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D017576:Daptomycin