title: A highly effective bifunctional ligand for radioimmunotherapy applications.
abstract: A novel bifunctional ligand (3p-C-NETA) for antibody-targeted radioimmunotherapy (RIT) of β-emitting radioisotopes (90)Y and (177)Lu was efficiently synthesized via an unexpected regiospecific ring opening of an aziridinium ion. 3p-C-NETA instantly formed a very stable complex with (90)Y or (177)Lu. 3p-C-NETA is an excellent bifunctional ligand for RIT.
authors.affiliation: Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, 3101 S. Dearborn St, LS 182, Chicago, IL, USA. chong@iit.edu
authors.forename: Hyun-Soon
authors.initials: HS
authors.lastname: Chong
authors.forename: Hyun A
authors.initials: HA
authors.lastname: Song
authors.forename: Chi Soo
authors.initials: CS
authors.lastname: Kang
authors.forename: Thien
authors.initials: T
authors.lastname: Le
authors.forename: Xiang
authors.initials: X
authors.lastname: Sun
authors.forename: Mamta
authors.initials: M
authors.lastname: Dadwal
authors.forename: Hyunbeom
authors.initials: H
authors.lastname: Lee
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Lan
authors.forename: Yunwei
authors.initials: Y
authors.lastname: Chen
authors.forename: Anzhi
authors.initials: A
authors.lastname: Dai
mesh_terms: D001610:Beta Particles / Q000627:therapeutic use; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D008024:Ligands; D016499:Radioimmunotherapy; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: C529856:(2-(4,7-biscarboxymethyl(1,4,7)triazacyclonona-1-yl-ethyl)carbonylmethylamino)acetic acid; D003432:Cross-Linking Reagents; D006571:Heterocyclic Compounds; D008024:Ligands