title: Ayurvedic medicine zinc bhasma: physicochemical evaluation, anti-diabetic activity and safety assessment.
abstract: Bhasmas are unique Ayurvedic metallic preparations used for medicinal purposes since ancient times. With increasing knowledge of risk of nanomaterials, it becomes imperative to assess the safety of nanoparticulate Ayurvedic medicines using toxicity models. In this study, zinc bhasma was characterized using modern physicochemical techniques. In vitro toxicity test revealed no major cytotoxicity at all the dose levels tested. No behavioral abnormality, clinical signs and mortality was seen indicating no adverse effects. SGOT, SGPT and serum urea were also not significantly altered indicating no major organ toxicity. In the current study, zinc bhasma appears safe for human use.
authors.affiliation: Centre for Nanobioscience, Agharkar Research Institute, G. G. Agarkar Road, Pune 411004, India.
authors.forename: Rinku D
authors.initials: RD
authors.lastname: Umrani
authors.forename: Kishore M
authors.initials: KM
authors.lastname: Paknikar
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000188:drug therapy*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects; D008515:Medicine, Ayurvedic; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000009:adverse effects*; D051381:Rats; D013311:Streptozocin; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D013311:Streptozocin