title: A combination of grape extract, green tea extract and L-carnitine improves high-fat diet-induced obesity, hyperlipidemia and non-alcoholic fatty liver disease in mice.
abstract: To develop a therapeutic agent for obesity-related metabolic disorders, a mixture of dietary components was prepared, including grape extract, green tea extract and l-carnitine (RGTC), and its effects on obesity, hyperlipidemia and non-alcoholic fatty liver disease examined. The RGTC dramatically inhibited the high-fat diet (HFD)-induced increase in body weight and fat in C57BL/6 mice, whereas food consumption was not affected by RGTC treatment. The RGTC also concentration-dependently suppressed the HFD-induced increase in plasma lipids, such as low-density lipoprotein cholesterol and triglycerides. In addition, increases in liver weight and liver steatosis were returned to normal by RGTC treatment in HFD-fed C57BL/6 mice. The plasma levels of glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase were also significantly down-regulated by RGTC treatment. These results suggest that RGTC suppressed HFD-induced obesity, hyperlipidemia and non-alcoholic fatty liver disease, suggesting that RGTC supplementation might be a promising adjuvant therapy for the treatment of these metabolic disorders.
authors.affiliation: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Republic of Korea.
authors.forename: Jong Soon
authors.initials: JS
authors.lastname: Kang
authors.forename: Won Kyung
authors.initials: WK
authors.lastname: Lee
authors.forename: Won Kee
authors.initials: WK
authors.lastname: Yoon
authors.forename: Nayang
authors.initials: N
authors.lastname: Kim
authors.forename: Sang-Ki
authors.initials: SK
authors.lastname: Park
authors.forename: Hyoung Kook
authors.initials: HK
authors.lastname: Park
authors.forename: Sun Yung
authors.initials: SY
authors.lastname: Ly
authors.forename: Sang-Bae
authors.initials: SB
authors.lastname: Han
authors.forename: Jieun
authors.initials: J
authors.lastname: Yun
authors.forename: Chang Woo
authors.initials: CW
authors.lastname: Lee
authors.forename: Kiho
authors.initials: K
authors.lastname: Lee
authors.forename: Ki Hoon
authors.initials: KH
authors.lastname: Lee
authors.forename: Song-Kyu
authors.initials: SK
authors.lastname: Park
authors.forename: Hwan Mook
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D002331:Carnitine / Q000494:pharmacology*; D059305:Diet, High-Fat; D005234:Fatty Liver / Q000188:drug therapy*; D006949:Hyperlipidemias / Q000188:drug therapy*; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry; D027843:Vitis / Q000737:chemistry
chemical_list: D020738:Leptin; D008055:Lipids; D010936:Plant Extracts; D013662:Tea; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002331:Carnitine