title: Attitudes toward genetic research review: results from a survey of human genetics researchers.
abstract: BACKGROUND
  Researchers often relate personal experiences of difficulties and challenges with Institutional Review Board (IRB) review of their human genetic research protocols. However, there have been no studies that document the range and frequency of these concerns among researchers conducting human genetic/genomic studies.
  
  
  METHODS
  An online anonymous survey was used to collect information from human genetic researchers regarding views about IRB review of genetic protocols. Logistic regression was used to test specific hypotheses. Results from the national online survey of 351 human genomic researchers are summarized in this report.
  
  
  RESULTS
  Issues involving considerable discussion with IRBs included reconsent of subjects (51%), protection of participants' personal information (39%) and return of results to participants (34%). Over half of the participants had experienced one or more negative consequences of the IRB review process and approximately 25% had experienced one or more positive consequences. Respondents who had served on an IRB were about 80% more likely to report positive consequences of IRB review than their colleagues who had never served on an IRB (p = 0.03). Survey responses were mixed on the need for reconsent before data sharing and risks related to participant reidentification from genomic data.
  
  
  CONCLUSIONS
  The results from this study provide important perspectives of researchers regarding genetic research review and show lack of consensus on key research ethics issues in genomic research.
authors.affiliation: Department of Epidemiology, University of Washington, Seattle, WA 98115, USA. keddy@uw.edu
authors.forename: K L
authors.initials: KL
authors.lastname: Edwards
authors.forename: A A
authors.initials: AA
authors.lastname: Lemke
authors.forename: S B
authors.initials: SB
authors.lastname: Trinidad
authors.forename: S M
authors.initials: SM
authors.lastname: Lewis
authors.forename: H
authors.initials: H
authors.lastname: Starks
authors.forename: M T
authors.initials: MT
authors.lastname: Quinn Griffin
authors.forename: G L
authors.initials: GL
authors.lastname: Wiesner
mesh_terms: D001290:Attitude; D001675:Bioethics; D003219:Confidentiality; D003625:Data Collection; D028744:Ethics Committees, Research; D005260:Female; D036281:Genetic Research / Q000941:ethics*; D005823:Genetics / Q000639:trends*; D023281:Genomics; D006801:Humans; D007258:Informed Consent; D008297:Male; D018907:Privacy; D012044:Regression Analysis; D012108:Research Personnel; D012984:Software