title: [Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8)].
abstract: Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8, HHV-8) are members of gamma-herpes virus family. Both viruses infect to B cells and cause malignancies such as lymphoma. Since EBV and HHV-8 are so-called 'oncovirus', their oncogenecities have been focused in the researches on EBV and KSHV for a long time. EBV was discovered in 1964, whereas KSHV was identified in 1994. However, KSHV was analyzed rapidly in these fifteen years. One of the recent progresses in the research on EBV and KSHV is that virus-encoded small RNAs were identified in their genomes and characterized. EBV is the first human virus in whose genome microRNA was identified. The oncogenecity of EBV and KSHV remains unclear. Here, I discuss the pathogenesis by EBV and KSHV with special reference to recent progress in this field.
authors.affiliation: Department of Pathology, National Institute of Infectious Diseases 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan. katano@nih.go.jp
authors.forename: Harutaka
authors.initials: H
authors.lastname: Katano
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000821:virology; D019175:DNA Methylation; D019309:Epstein-Barr Virus Nuclear Antigens; D015967:Gene Expression Regulation, Viral; D016147:Genes, Tumor Suppressor; D016679:Genome, Viral / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D008223:Lymphoma / Q000235:genetics / Q000821:virology*; D035683:MicroRNAs; D012367:RNA, Viral; D012514:Sarcoma, Kaposi / Q000821:virology*; D017735:Virus Latency / Q000235:genetics; D014779:Virus Replication
chemical_list: D019309:Epstein-Barr Virus Nuclear Antigens; C099537:Epstein-Barr virus encoded RNA 1; C106732:Epstein-Barr virus encoded RNA 2; D035683:MicroRNAs; D012367:RNA, Viral; C417029:EBV-encoded nuclear antigen 1