title: Angustimine and angustifolimine: two new alkaloids from Daphniphyllum angustifolium.
abstract: Two new alkaloids, angustimine (1) featuring an unprecedented skeleton, and angustifolimine (2) being a rare diamino Daphniphyllum alkaloid, were isolated from Daphniphyllum angustifolium. Their structures were elucidated by extensive spectroscopic analysis. The biosynthetic origin of 1 was postulated. Cytotoxic activities of 1 and 2 were tested, and all of them were inactive.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Chuan-Rui
authors.initials: CR
authors.lastname: Zhang
authors.forename: Cheng-Qi
authors.initials: CQ
authors.lastname: Fan
authors.forename: Shi-Hui
authors.initials: SH
authors.lastname: Dong
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Liu
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Zhou
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; C559811:angustifolimine; C559810:angustimine