title: Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer.
abstract: Inflammation has been suggested to be involved in cancer development and progression. Many clinical and experimental studies have shown that inflammation could contribute to ovarian carcinogenesis through activation of the NF-κB and AP-1 pathways by chronic inflammatory mediators. Phytochemicals, which are natural compounds derived from fruits and vegetables, have shown anti-inflammatory and anti-cancer effects. Due to their relatively low toxicity and easy accessibility, phytochemicals have been investigated for their chemopreventive potential against various cancers. In this review, we discuss the role of phytochemicals in preventing ovarian cancer through anti-inflammatory mechanisms.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul, 110-744, Republic of Korea.
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Kim
authors.forename: Kidong
authors.initials: K
authors.lastname: Kim
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Han
authors.forename: Jeong Mook
authors.initials: JM
authors.lastname: Lim
authors.forename: Yong Sang
authors.initials: YS
authors.lastname: Song