title: Subfoveal choroidal thickness in fellow eyes of patients with central serous chorioretinopathy.
abstract: OBJECTIVE
  To evaluate the subfoveal choroidal thickness in the fellow eyes of patients with CSC, a disease often associated with choroidal vascular hyperpermeability even in eyes without subretinal fluid.
  
  
  METHODS
  In this observational cross-sectional study, we measured the bilateral subfoveal choroidal thickness in patients with unilateral CSC using enhanced depth imaging spectral-domain optical coherence tomography. Areas of choroidal vascular hyperpermeability were visualized with indocyanine green angiography.
  
  
  RESULTS
  Sixty-six consecutive Japanese patients (50 men, 16 women; mean age, 52.8 years) with unilateral CSC were examined. The subfoveal choroid in symptomatic eyes was significantly thicker than that in fellow eye (414 ± 109 μm vs. 350 ± 116 μm, P < 0.001, respectively). The subfoveal choroid of eyes with choroidal vascular hyperpermeability was 410 ± 92 μm, which differed significantly (P < 0.001) from the choroid (239 ± 59 μm) of fellow eyes without choroidal vascular hyperpermeability.
  
  
  CONCLUSIONS
  The subfoveal choroid in the fellow eyes of patients with CSC was thicker in the eyes with choroidal vascular hyperpermeability. Enhanced depth imaging spectral-domain optical coherence tomography can assess the effects of choroidal vascular hyperpermeability by measuring the choroidal thickness noninvasively.
authors.affiliation: Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan. imaruko@fmu.ac.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Maruko
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Iida
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Sugano
authors.forename: Akira
authors.initials: A
authors.lastname: Ojima
authors.forename: Tetsuju
authors.initials: T
authors.lastname: Sekiryu
mesh_terms: D002199:Capillary Permeability; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000503:physiopathology; D002829:Choroid / Q000098:blood supply / Q000473:pathology*; D004396:Coloring Agents; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green