title: Pharmacokinetic study of rhizoma Curcumae oil and rhizoma Curcumae oil-β-cyclodextrin inclusion complex in pigs after oral administration.
abstract: Pharmacokinetics of rhizoma Curcumae oil-pure drug (RCO-PD) and its β-cyclodextrin inclusion complex (RCO-βCD) were studied in a randomized two-way crossover design following a single oral administration of the two formulations. Germacrone concentrations in plasma were determined by high-performance liquid chromatography with UV detector. The concentrations vs. time data were analyzed by a noncompartmental pharmacokinetic method. The result showed that germacrone in both groups was rapidly absorbed followed by a slow elimination. The main parameters in RCO-PD group were as follows: t(1/2λz) 6.63±1.08 h, C(max) 2.50±0.34 μg/mL, MRT 7.19±0.93 h, and AUC(0-∞) 13.92±2.75 mg/L·h, while in RCO-βCD group, t(1/2λz) 6.77 ± 0.67 h, C(max) 2.98±0.24 μg/mL, MRT 8.87±0.76 h, and AUC(0-∞) 21.60 ± 1.95 mg/L·h, respectively. The above results indicated that C(max), T(max), AUC(0-t), AUC(0-∞), and MRT in RCO-βCD group were significantly different from RCO-PD group, and the relative bioavailability of RCO-βCD group is significantly higher while compared to RCO-PD group (F=156%, with its 90% confidence interval of 145-169%).
authors.affiliation: Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China. sunyx@scau.edu.cn
authors.forename: S
authors.initials: S
authors.lastname: Yong-Xue
authors.forename: L
authors.initials: L
authors.lastname: Yongjin
authors.forename: Z
authors.initials: Z
authors.lastname: Dongping
authors.forename: W
authors.initials: W
authors.lastname: Gang
authors.forename: L
authors.initials: L
authors.lastname: Zhichang
authors.forename: Z
authors.initials: Z
authors.lastname: Haiyan
mesh_terms: D000818:Animals; D019540:Area Under Curve; D018592:Cross-Over Studies; D030024:Curcuma / Q000737:chemistry*; D005260:Female; D006207:Half-Life; D008297:Male; D010938:Plant Oils / Q000008:administration & dosage / Q000493:pharmacokinetics*; D027343:Rhizome / Q000737:chemistry*; D013552:Swine / Q000097:blood / Q000378:metabolism*; D047392:beta-Cyclodextrins / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D010938:Plant Oils; D047392:beta-Cyclodextrins; C031215:betadex