title: Cochlear function in 1-year-old term infants born with hypoxia-ischaemia or low Apgar scores.
abstract: OBJECTIVE
  To examine the influence of perinatal hypoxia-ischaemia (HI) or low Apgar scores on distortion product otoacoustic emissions (DPOAEs) in infants at 1 year and detect any postnatal changes.
  
  
  METHODS
  Eighty-eight term infants born with perinatal HI or low Apgar scores alone were recruited at 1 year of age. The ears with type A tympanogram (normal) were studied with DPOAEs at 10 frequencies between 0.5 kHz and 10 kHz.
  
  
  RESULTS
  DPOAE pass rates were decreased at all frequencies 1-10 kHz, particularly 1 and 2 kHz in both infants born with HI and those with low Apgar scores (χ(2) = 3.80-15.09, P < 0.05-0.01). Overall pass rates in the two groups were also decreased (X(2) = 10.78 and 12.12, P < 0.01 and 0.01). No marked differences were found between infants born with HI and those with low Apgar score. Compared with those recorded at 1 and 6 months, DPOAE pass rates at 1 year were increased slightly in infants born with HI, but showed no marked changes in those born with low Apgar scores.
  
  
  CONCLUSIONS
  DPOAE pass rates, mainly at 1 and 2 kHz, were decreased at 1 year in infants born with perinatal HI and low Apgar scores, suggesting a relative poor cochlear function. Further studies are needed to ascertain the hearing acuity.
authors.affiliation: Children's Hospital, Fudan University, Shanghai, China. zedong.jiang@paediatrics.ox.ac.uk
authors.forename: Ze D
authors.initials: ZD
authors.lastname: Jiang
authors.forename: Zeng
authors.initials: Z
authors.lastname: Zang
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Wilkinson
mesh_terms: D001034:Apgar Score; D003051:Cochlea / Q000503:physiopathology*; D034381:Hearing Loss / Q000209:etiology*; D006320:Hearing Tests; D006801:Humans; D000860:Hypoxia / Q000150:complications*; D007223:Infant; D007231:Infant, Newborn; D007511:Ischemia / Q000150:complications*; D017084:Otoacoustic Emissions, Spontaneous