title: Antimalarial effects of human immunodeficiency virus protease inhibitors in rhesus macaques.
abstract: The antimalarial activity of the human immunodeficiency virus protease inhibitors indinavir and saquinavir was evaluated in rhesus macaques for the first time. Indinavir effectively suppressed the growth of Plasmodium cynomolgi and Plasmodium knowlesi in vivo after a 7- or 3-day treatment, respectively, with clinically relevant doses, whereas saquinavir showed only weak activity against P. cynomolgi.
authors.affiliation: Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530 Guangdong, China.
authors.forename: Youjia
authors.initials: Y
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Qin
authors.forename: Nanzheng
authors.initials: N
authors.lastname: Peng
authors.forename: Guangjie
authors.initials: G
authors.lastname: Liu
authors.forename: Siting
authors.initials: S
authors.lastname: Zhao
authors.forename: Zhengxiang
authors.initials: Z
authors.lastname: He
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D019469:Indinavir / Q000494:pharmacology*; D008253:Macaca mulatta; D016789:Plasmodium cynomolgi / Q000187:drug effects; D016790:Plasmodium knowlesi / Q000187:drug effects; D019258:Saquinavir / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D017320:HIV Protease Inhibitors; D019469:Indinavir; D019258:Saquinavir