title: Thematic Analysis™: a chemogenomic approach to GPCR drug discovery.
abstract: Thematic Analysis™ is a chemogenomic tool which has been developed and used to aid the process of GPCR drug discovery. This review covers the scientific rationale behind the development of this tool and provides examples of the successful application of the chemogenomic method in both hit finding and hit to lead stages of the drug discovery process.
authors.affiliation: Crosspatch, 3 Bossington Oast, Adisham, Canterbury, Kent, UK.
authors.forename: Roger
authors.initials: R
authors.lastname: Crossley
authors.forename: Jacqueline Anne
authors.initials: JA
authors.lastname: Macritchie
authors.forename: Martin John
authors.initials: MJ
authors.lastname: Slater
mesh_terms: D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D023281:Genomics; D006801:Humans; D008024:Ligands; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D043562:Receptors, G-Protein-Coupled