title: Genetic variations in CD14 promoter and acute lymphoblastic leukemia susceptibility in a Chinese population.
abstract: Recent findings suggest that CD14 may play a role in tumor development. Previous case-control studies have revealed that CD14 -260C/T and -651 C/T polymorphisms contribute to the risk of human diseases. However, the relationship between these two functional polymorphisms and susceptibility to acute lymphoblastic leukemia (ALL) has not been explored. In this study, we performed a case-control study in a Chinese population. We found that an increased risk of ALL was associated with the -260 TT (odds ratio [OR]=1.85, 95% confidence interval [CI]=1.26-2.63) genotype compared with the CT or CC genotype. No significant association was found between -651 CC genotype and ALL (OR=1.13, 95% CI=0.77-1.69). Moreover, the increased risk was only associated with the -260 TT genotype in B-ALL (OR=1.99, 95% CI=1.34-3.01) but not in T-ALL (OR=1.48, 95% CI=0.79-2.84). The findings suggest that CD14-260C/T polymorphism can contribute to B-ALL risk in a Chinese population.
authors.affiliation: Soochow University Laboratory of Cancer Molecular Genetics, Department of Hematology, Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yu
authors.forename: Chun
authors.initials: C
authors.lastname: Zhang
authors.forename: Aining
authors.initials: A
authors.lastname: Sun
authors.forename: Lan
authors.initials: L
authors.lastname: Jiang
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
authors.forename: Yonghe
authors.initials: Y
authors.lastname: You
authors.forename: Depei
authors.initials: D
authors.lastname: Wu
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D016172:DNA Fingerprinting; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000235:genetics*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012307:Risk Factors
chemical_list: D018950:Lipopolysaccharide Receptors