title: Genetic associations of autopsy-confirmed vascular dementia subtypes.
abstract: OBJECTIVE
  Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease.
  
  
  METHODS
  Samples were genotyped for APOE, MTHFR and ICAM. Aβ levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD.
  
  
  RESULTS
  Associations were found between the APOE-ε4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher Aβ1-42 levels and decreased ChAT activity. MTHFR was more associated with SIVD, mixed dementia, and lower ChAT activity.
  
  
  CONCLUSIONS
  The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates.
authors.affiliation: Wolfson CARD, King's College London, London, UK. emma.3.jones@kcl.ac.uk
authors.forename: Emma L
authors.initials: EL
authors.lastname: Jones
authors.forename: Rajesh N
authors.initials: RN
authors.lastname: Kalaria
authors.forename: Sally I
authors.initials: SI
authors.lastname: Sharp
authors.forename: John T
authors.initials: JT
authors.lastname: O'Brien
authors.forename: Paul T
authors.initials: PT
authors.lastname: Francis
authors.forename: Clive G
authors.initials: CG
authors.lastname: Ballard
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001057:Apolipoproteins E / Q000235:genetics*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D015140:Dementia, Vascular / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000235:genetics / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D018799:Intercellular Adhesion Molecule-1; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D002795:Choline O-Acetyltransferase