title: Supplementary motor cortex involvement in reading epilepsy revealed by magnetic source imaging.
abstract: Reading epilepsy (RE) is an idiopathic reflex epilepsy syndrome characterized by perioral myoclonic jerks (PMJs) during reading associated with left-dominant frontotemporal spike-wave discharges (SWDs). To better understand the pathophysiology of this syndrome, we studied a 45-year-old patient using magnetic source imaging (MSI). The patient underwent two whole-head magnetoencephalography (MEG) recordings (Elekta Neuromag Oy) within 2 months while reading aloud. Forty-two SWDs associated with PMJs were recorded and averaged with respect to SWDs peak power. Epileptic discharges were then reconstructed using conventional equivalent current dipoles (ECDs) modeling, distributed sources sLORETA modeling, and beamformer approach. These methods identified two brain sources located in the left supplementary motor cortex (SMC) and the left primary sensorimotor face area (PSMFA). The spatiotemporal pattern of the sources was characterized by a cross-talk between these two brain regions, with an initial source in the left SMC. This MSI investigation suggests that RE-PMJs are associated with reading-induced activation of hyperexcitable neurons in the left SMC, followed by secondary propagation to the left PSMFA producing the myoclonus.
authors.affiliation: Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB-Hôpital Erasme, Brussels, Belgium. maopdebe@ulb.ac.be
authors.forename: Marc
authors.initials: M
authors.lastname: Op de beeck
authors.forename: Benjamin
authors.initials: B
authors.lastname: Legros
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gaspard
authors.forename: Mathieu
authors.initials: M
authors.lastname: Bourguignon
authors.forename: Fabrice
authors.initials: F
authors.lastname: Jurysta
authors.forename: Patrick
authors.initials: P
authors.lastname: Van Bogaert
authors.forename: Serge
authors.initials: S
authors.lastname: Goldman
authors.forename: Veikko
authors.initials: V
authors.lastname: Jousmäki
authors.forename: Xavier
authors.initials: X
authors.lastname: De Tiège
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001931:Brain Mapping; D003987:Dibenzothiazepines / Q000009:adverse effects / Q000627:therapeutic use; D004576:Electromyography / Q000379:methods / Q000706:statistics & numerical data; D020195:Epilepsy, Reflex / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods / Q000706:statistics & numerical data*; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D000069348:Quetiapine Fumarate; D012560:Schizophrenia, Catatonic / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate