title: [Antinicrobial, antiexudative and immunotropic properties of chlorhexidine bigluconate in combination with zinc oxide, succinic and ascorbic acids].
abstract: Optimal combination of chlorhexidine bigluconate with ascorbic acid, succinic acid, and zinc oxide was found as a result of comparative trials. The composition shows antioxidative effects and is capable of initiating antibody producing and phagocytosis. This combination can be used as an active substance of orodispersible tablets for the treatment respiratory tract infections.
authors.forename: T N
authors.initials: TN
authors.lastname: Savateeva-Liubimova
authors.forename: E E
authors.initials: EE
authors.lastname: Lesiovskaia
authors.forename: K V
authors.initials: KV
authors.lastname: Sivak
authors.forename: K I
authors.initials: KI
authors.lastname: Stosman
authors.forename: G S
authors.initials: GS
authors.lastname: Stroĭkova
authors.forename: T A
authors.initials: TA
authors.lastname: Rassokha
authors.forename: L I
authors.initials: LI
authors.lastname: Rudenko
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000917:Antibody Formation; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D004926:Escherichia coli / Q000187:drug effects; D005122:Exudates and Transudates / Q000187:drug effects*; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects; D019802:Succinic Acid / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013607:Tablets; D015034:Zinc Oxide / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D004338:Drug Combinations; D007155:Immunologic Factors; D013607:Tablets; D019802:Succinic Acid; C010882:chlorhexidine gluconate; D001205:Ascorbic Acid; D002710:Chlorhexidine; D015034:Zinc Oxide