title: Risk factors for neurodevelopmental deficits in congenital hypothyroidism after early substitution treatment.
abstract: Neurodevelopment in children with congenital hypothyroidism who receive early treatment is generally good. However, subtle neurological deficits still exist in some patients. The aim of this investigation was to evaluate factors that may influence neurodevelopmental outcome in congenital hypothyroidism patients. The developmental quotient (DQ) of 155 children with congenital hypothyroidism was evaluated at 24 months of age, using Gesell Developmental Schedules (GDS), and compared with that of 310 healthy controls. Mean DQ scores in congenital hypothyroidism patients were 7.5 points lower for adaptive behavior than in control patients (p < 0.01). Patients with severe congenital hypothyroidism had the lowest DQ scores compared with two other congenital hypothyroidism subgroups and controls (p < 0.01). Children with congenital hypothyroidism who also had a low level of serum T(4) at diagnosis or exhibited a longer thyroid stimulating hormone (TSH) normalization time had lower adaptive behavior scores (p < 0.0003). Bivariate correlation and multiple regression analyses found that the severity of congenital hypothyroidism and parental socioeconomic status correlated with DQ scores. TSH normalization time was negatively related to adaptive behavior scores (p < 0.01). Neurodevelopmental deficits in children with congenital hypothyroidism correlate with the severity of congenital hypothyroidism, TSH normalization time, and parental socioeconomic status.
authors.affiliation: Department of Pediatrics, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Huo
authors.forename: Zhan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Dehua
authors.initials: D
authors.lastname: Zhao
authors.forename: Hezhou
authors.initials: H
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Xinxia
authors.initials: X
authors.lastname: Wang
authors.forename: Hongqi
authors.initials: H
authors.lastname: Feng
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Wang
authors.forename: Changlian
authors.initials: C
authors.lastname: Zhu
mesh_terms: D002657:Child Development; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000097:blood / Q000150:complications*; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007360:Intelligence; D007859:Learning Disabilities / Q000209:etiology*; D008297:Male; D015997:Neonatal Screening; D010290:Parents; D012307:Risk Factors; D012923:Social Class; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D016896:Treatment Outcome
chemical_list: D013972:Thyrotropin; D013974:Thyroxine