title: Melidianolic acid A and B, new antimalarial acyclic diterpenes from Aphanamixis grandifolia.
abstract: Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 microg/mL, respectively.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Adil
authors.initials: A
authors.lastname: Astulla
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Abdul
authors.initials: A
authors.lastname: Rahman
authors.forename: Idha
authors.initials: I
authors.lastname: Kusumawati
authors.forename: Wiwied
authors.initials: W
authors.lastname: Ekasari
authors.forename: Aty
authors.initials: A
authors.lastname: Widyawaruyanti
authors.forename: Noor Cholies
authors.initials: NC
authors.lastname: Zaini
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D029582:Meliaceae / Q000737:chemistry*; D008968:Molecular Conformation; D009904:Optical Rotation; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts; C558333:melidianolic acid A; C558334:melidianolic acid B