title: Role of natural product diversity in chemical biology.
abstract: Through the natural selection process, natural products possess a unique and vast chemical diversity and have been evolved for optimal interactions with biological macromolecules. Owing to their diversity, target affinity, and specificity, natural products have demonstrated enormous potential as modulators of biomolecular function, been an essential source for drug discovery, and provided design principles for combinatorial library development.
authors.affiliation: Department of Chemistry, Duke University, Durham, NC 27708, USA. jiyong.hong@duke.edu
authors.forename: Jiyong
authors.initials: J
authors.lastname: Hong
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D002621:Chemistry / Q000379:methods; D055808:Drug Discovery; D005786:Gene Expression Regulation; D023281:Genomics / Q000379:methods; D054852:Small Molecule Libraries
chemical_list: D001688:Biological Products; D054852:Small Molecule Libraries