title: Endocannabinoid type 1 receptor gene (CNR1) polymorphisms (rs806381, rs10485170, rs6454674, rs2023239) and cardiovascular risk factors in postmenopausal women.
abstract: BACKGROUND
  The risk of cardiovascular diseases (CVD) in women increases with menopausal stage. Obesity with metabolic disorders is the most important risk factor for CVD. The incidence of this phenotype of obesity increases in postmenopausal women. The endocannabinoid system plays an important role in regulation of several metabolic pathways. The aim of this work was to investigate whether genetic variations in the cannabinoid receptor gene (CNR1) can affect cardiovascular risk factors (e.g. fat distribution, obesity, fasting glucose, lipid profile, blood pressure, and free androgen and estrogen indexes) in postmenopausal women.
  
  
  METHODS
  The rs806381, rs10485170, rs6454674, and rs2023239 polymorphisms of the CNR1 gene were genotyped in 384 randomly selected postmenopausal Polish women (aged 50-60) using the minisequencing technique.
  
  
  RESULTS
  The rs806381, rs10485170, rs6454674, and rs2023239 polymorphisms were not significantly associated with anthropometric measures (waist circumference, carbohydrate and lipid metabolism, body mass index [BMI], total fat, glucose, insulin, fasting insulin resistance index [FIRI]). However, the rs2023239 polymorphism was associated with the free androgen index (p = 0.03).
  
  
  CONCLUSIONS
  It seems that further genotyping of the endocannabinoid receptor gene cannot be used as a significant marker of predisposition to CVD in postmenopausal women, but it would be interesting to study this interrelation on a larger population of postmenopausal women.
authors.affiliation: Department of Endocrinology and Diabetology, Wroclaw Medical University, Poland. laczman@endo.am.wroc.pl
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Łaczmański
authors.forename: Andrzej
authors.initials: A
authors.lastname: Milewicz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Dunajska
authors.forename: Diana
authors.initials: D
authors.lastname: Jędrzejczuk
authors.forename: Maurycy
authors.initials: M
authors.lastname: Pawlak
authors.forename: Felicja
authors.initials: F
authors.lastname: Lwow
mesh_terms: D001837:Body Weights and Measures; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D015331:Cohort Studies; D063388:Endocannabinoids; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000502:physiology*; D017698:Postmenopause / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D043884:Receptor, Cannabinoid, CB1