title: Blocking HIF1α activity eliminates hematological cancer stem cells.
abstract: Selective targeting of cancer stem cells (CSCs) has the potential to prevent cancer relapse. Wang et al. (2011) report that hypoxia-inducible factor 1α (HIF1α) represses Notch signaling to maintain CSC subsets from lymphoma, and that blocking HIF1α activity eliminates lymphoma and human acute myeloid leukemia (AML) CSCs.
authors.affiliation: Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Ben S
authors.initials: BS
authors.lastname: Lam
authors.forename: Gregor B
authors.initials: GB
authors.lastname: Adams