title: [Evaluation of clinical, laboratorial and ultrasonographic predicting factors of malignancy in thyroid nodules].
abstract: OBJECTIVE
  To evaluate the risk of malignancy in thyroid nodules through clinical, laboratory, ultrasonographic and cytological aspects.
  
  
  METHODS
  741 nodules of 407 patients.
  
  
  RESULTS
  The cytology was benign (60,5%), indeterminate (23,3%), malignant (8,3%) or nondiagnostic (7,6%). The prevalence of cancer in indeterminate citology was 18,5% (16% in follicular lesions, 44% in suspicious). The diagnosis of malignancy was 17,2% (n = 70). The frequency of cancer in women (15,2%) was lower than in men (27,9%). There was an inverse relation between age and cancer risk. There was no statistical significance in the prevalence of cancer according to number, size of nodules or TSH levels. Hypoechogenicity and microcalcifications on ultrasound were risk factors.
  
  
  CONCLUSIONS
  The risk of malignancy was higher in men, hypoechoic nodules, with microcalcifications and was inversely related to age. The TSH level was not an independent factor predictive of malignancy.
authors.affiliation: Disciplina de Endocrinologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil. anario01@hotmail.com
authors.forename: Ana Luiza Silva
authors.initials: AL
authors.lastname: Rio
authors.forename: Rosa Paula Mello
authors.initials: RP
authors.lastname: Biscolla
authors.forename: Danielle Macellaro
authors.initials: DM
authors.lastname: Andreoni
authors.forename: Cléber Pinto
authors.initials: CP
authors.lastname: Camacho
authors.forename: Cláudia Cristina Doimo
authors.initials: CC
authors.lastname: Nakabashi
authors.forename: Maria da Conceição de Oliveira Carneiro
authors.initials: Mda C
authors.lastname: Mamone
authors.forename: Elza Setsuku
authors.initials: ES
authors.lastname: Ikejiri
authors.forename: Luiza K
authors.initials: LK
authors.lastname: Matsumura
authors.forename: Jairo Tabacow
authors.initials: JT
authors.lastname: Hidal
authors.forename: Rui Monteiro de Barros
authors.initials: RM
authors.lastname: Maciel
authors.forename: Reinaldo Perrone
authors.initials: RP
authors.lastname: Furlanetto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000379:methods; D002114:Calcinosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002277:Carcinoma / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D002648:Child; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography; D055815:Young Adult