title: Entry and exit mechanisms at the cis-face of the Golgi complex.
abstract: Vesicular transport of protein and lipid cargo from the endoplasmic reticulum (ER) to cis-Golgi compartments depends on coat protein complexes, Rab GTPases, tethering factors, and membrane fusion catalysts. ER-derived vesicles deliver cargo to an ER-Golgi intermediate compartment (ERGIC) that then fuses with and/or matures into cis-Golgi compartments. The forward transport pathway to cis-Golgi compartments is balanced by a retrograde directed pathway that recycles transport machinery back to the ER. How trafficking through the ERGIC and cis-Golgi is coordinated to maintain organelle structure and function is poorly understood and highlights central questions regarding trafficking routes and organization of the early secretory pathway.
authors.affiliation: Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
authors.forename: Andrés
authors.initials: A
authors.lastname: Lorente-Rodríguez
authors.forename: Charles
authors.initials: C
authors.lastname: Barlowe
mesh_terms: D022181:COP-Coated Vesicles / Q000378:metabolism / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D008561:Membrane Fusion; D050576:Membrane Fusion Proteins / Q000502:physiology; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D055571:Secretory Pathway; D033921:Vesicular Transport Proteins / Q000737:chemistry / Q000502:physiology
chemical_list: D050576:Membrane Fusion Proteins; D033921:Vesicular Transport Proteins; C406327:transport protein particle, TRAPP