title: High prevalence of virulence-associated genotypes in Helicobacter pylori clinical isolates in the Region del Maule, Chile.
abstract: The prevalence of Helicobacter pylori infection and the gastric cancer mortality rate in Chile are remarkably high. This study identified some virulence-associated genes in 78 H. pylori clinical isolates from dyspeptic patients from the Region del Maule, which is the region with the higher gastric cancer mortality rate in the country. The cagA, vacA and babA2 genes were detected in 94.9%, 100% and 97.4%, respectively. Two or more EPIYA C motifs were presented in 48.6% of cagA-positive strains, and this was associated with more severe histopathological findings in the gastric mucosa.
authors.affiliation: Biomedical Research Laboratories, Faculty of Medicine, Catholic University of Maule, Talca, Chile.
authors.forename: Ileana
authors.initials: I
authors.lastname: González
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Romero
authors.forename: Boris
authors.initials: B
authors.lastname: Rodríguez
authors.forename: Jorge
authors.initials: J
authors.lastname: Llanos
authors.forename: Erik
authors.initials: E
authors.lastname: Morales
authors.forename: Héctor
authors.initials: H
authors.lastname: Figueroa
authors.forename: Ramón
authors.initials: R
authors.lastname: Perez-Castro
authors.forename: Eliana
authors.initials: E
authors.lastname: Valdés
authors.forename: Cecilia
authors.initials: C
authors.lastname: Cofre
authors.forename: Armando
authors.initials: A
authors.lastname: Rojas
mesh_terms: D018829:Adhesins, Bacterial / Q000235:genetics; D020816:Amino Acid Motifs; D000942:Antigens, Bacterial / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D016009:Chi-Square Distribution; D002677:Chile / Q000453:epidemiology; D005753:Gastric Mucosa / Q000382:microbiology; D005838:Genotype; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D015995:Prevalence; D014774:Virulence
chemical_list: D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; C400429:BabA protein, Helicobacter pylori; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori