title: A Hot Cross Bun sign from diffusion tensor imaging and tractography perspective.
abstract: A "Hot Cross Bun" sign on T2-weighted MRI was described as a result of selective loss of myelinated transverse pontocerebellar fibers and neurons in the pontine raphe with preservation of the pontine tegmentum and corticospinal tracts (CST). However, neuropathologic studies showed contradicting results with no sparing of the CST. This is a pictorial and quantitative demonstration of the sign on diffusion tensor imaging and tractography, which provides the imaging evidence that is consistent with neuropathologic findings.
authors.affiliation: Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. kokbeng.loh@gmail.com
authors.forename: Kok Beng
authors.initials: KB
authors.lastname: Loh
authors.forename: Kartini
authors.initials: K
authors.lastname: Rahmat
authors.forename: Shen-Yang
authors.initials: SY
authors.lastname: Lim
authors.forename: Norlisah
authors.initials: N
authors.lastname: Ramli
mesh_terms: D000328:Adult; D002531:Cerebellum / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D019578:Multiple System Atrophy / Q000473:pathology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009474:Neurons / Q000473:pathology; D011149:Pons / Q000473:pathology*; D011712:Pyramidal Tracts / Q000473:pathology*