title: [GABAC receptors: structure and functions].
abstract: Data on the structure, localization, physiology and pharmacology of GABA(C) receptors are reviewed. Thece receptors belong to cys-loop receptors and consist of rho1-3 subunits representing pentamers with five subunits that form a chloride channel. They are found in both central nervous system and peripheral organs. The pentamer can be homomeric, consisting of five similar protomers (e.g., p1), or heteromeric (pseudo-homomeric), consisting of rho1 and rho2 subunits. Chloride channel function also depends on the GABA(C) receptor subunit composition. The activation of GABAc receptors is accompanied by a change in the permeability of plasmatic membranes for C1 ions, which is followed by depolarization (presynaptic inhibition) or hyperpolarization (postsynaptic inhibition). There are a great number of the allosteric modulators, agonists and antagonists of GABA(C) receptors.
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
mesh_terms: D000818:Animals; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D006801:Humans; D009154:Mutation; D009928:Organ Specificity; D018079:Receptors, GABA / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*
chemical_list: D018755:GABA Agonists; D018756:GABA Antagonists; C087200:GABA-C receptor; D018079:Receptors, GABA