title: Preparation of tetanus toxoid and ovalbumin loaded gliadin nanoparticles for oral immunization.
abstract: Nanoparticles (NP) incorporating tetanus toxoid and a model antigen ovalbumin were prepared for investigation as delivery vehicles for oral immunization. Gliadin, the seed storage protein of wheat, was used as the carrier because of its biocompatibility, oral bioavailability and mucoadhesive properties. NP with approximately 50% w/w of antigen were size-stable over 3 weeks of testing.
authors.affiliation: Pharmaceutics Division, Central Drug Research Institute (CSIR), M. G. Marg, Lucknow 226001, India.
authors.forename: Heikham
authors.initials: H
authors.lastname: Kajal
authors.forename: Amit
authors.initials: A
authors.lastname: Misra
mesh_terms: D000284:Administration, Oral; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods*; D005903:Gliadin / Q000737:chemistry*; D007114:Immunization / Q000379:methods*; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D010047:Ovalbumin / Q000008:administration & dosage* / Q000737:chemistry; D013744:Tetanus Toxin / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D053769:Nanocapsules; D013744:Tetanus Toxin; D010047:Ovalbumin; D005903:Gliadin