title: IgG-F-actin antibodies in celiac disease and dermatitis herpetiformis.
abstract: Anti-actin antibodies are found in 52-85% of patients with autoimmune hepatitis or chronic active hepatitis and in 22% of patients with primary biliary cirrhosis. In patients with celiac disease, anti-actin antibodies correlate with the degree of villous atrophy. Studies on their involvement in celiac disease and dermatitis herpetiformis in Romania have not been done. The purpose of this study was to evaluate of the quality of IgG anti-F-actin antibodies (IgG-AAA) tests compared with IgA tissue transglutaminase antibodies (IgA-TgA) having IgA endomysial antibody (IgA-EmA) as gold standard in celiac disease and dermatitis herpetiformis and to see if there is any relationship between them. The study included 70 pediatric patients with celiac disease under gluten-free diets and 10 adult patients with dermatitis herpetiformis, during 2010. The IgG-AAA antibodies levels were determined by ELISA. Assessing the qualities of IgG-AAA compared to IgA-TgA, we obtained the following values sensitivity (Se) 27.8%, specificity (Sp) 79.4%, respectively Se 88.9%, Sp 79.4% in celiac disease and Se 33.3%, Sp 100%, respectively Se 100%, Sp 100% in dermatitis herpetiformis. Also, there was a prevalence of 24.3% and 30% of IgG-AAA in the two groups of patients, but no statistically significant associations were found. Therefore, we concluded that IgG-AAA can not replace IgA-TgA in children patients with celiac disease under gluten-free diets and in adult patients with dermatitis herpetiformis. AAA-IgG serum activity in both diseases exist, but without a relationship of association with them.
authors.affiliation: Department of Immunology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Gabriel.Samasca@umfcluj.ro
authors.forename: Gabriel
authors.initials: G
authors.lastname: Samaşca
authors.forename: Adrian
authors.initials: A
authors.lastname: Băican
authors.forename: Tudor
authors.initials: T
authors.lastname: Pop
authors.forename: Alexandru
authors.initials: A
authors.lastname: Pîrvan
authors.forename: Nicolae
authors.initials: N
authors.lastname: Miu
authors.forename: Mariana
authors.initials: M
authors.lastname: Andreica
authors.forename: Victor
authors.initials: V
authors.lastname: Cristea
authors.forename: Doru
authors.initials: D
authors.lastname: Dejica
mesh_terms: D000199:Actins / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002446:Celiac Disease / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003874:Dermatitis Herpetiformis / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D012383:Romania; D011503:Transglutaminases / Q000276:immunology; D055815:Young Adult
chemical_list: D000199:Actins; D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011503:Transglutaminases