title: [Expression of macrophage migration inhibition factor (MIF) in serum of patients with prostate cancer and its clinical significance].
abstract: OBJECTIVE
  to investigate the expression of macrophage migration inhibition factor (MIF) in serum of patients with prostate cancer and its clinical significance.
  
  
  METHODS
  the levels of serum MIF were measured by an enzyme linked immunosorbent assay (ELISA) in 36 patients with prostate cancer, 32 patients with benign prostatic hyperplasia (BPH) and 20 healthy male adults as healthy controls.
  
  
  RESULTS
  the MIF levels of patients with prostate cancer were significantly higher than those of the other two groups (p<0.05). The level of MIF was found to relate to the clinical stages and Gleason scores of prostate cancer (P<0.05).
  
  
  CONCLUSIONS
  MIF may play an important role in the oncogenesis and development of prostate cancer. The serum MIF level can be useful as a novel biomarker for the detection of prostate cancer as well as a predictor of disease progression.
authors.affiliation: Department of Urology of Kai Xian People's Hospital, Chongqing 405400, China.
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Tang
authors.forename: Xin
authors.initials: X
authors.lastname: Gou
authors.forename: Qi-xiang
authors.initials: QX
authors.lastname: Liu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000097:blood*; D016022:Case-Control Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis* / Q000097:blood* / Q000378:metabolism; D008297:Male; D011470:Prostatic Hyperplasia / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D008263:Macrophage Migration-Inhibitory Factors