title: Inflammation-related gene variants as risk factors for pancreatic cancer.
abstract: BACKGROUND
  Recent reports support an association between chronic inflammation and progression to pancreatic cancer (PC).
  
  
  METHODS
  This case-control, candidate gene association study evaluated 1,354 Caucasian patients with pancreatic ductal adenocarcinoma and 1,189 healthy Caucasian controls. We genotyped 1,538 single nucleotide polymorphism (SNP) in 102 genes from inflammatory pathways involving NF-κB. Primary tests of association assumed a multiplicative (log-additive) genotype effect; secondary analyses examined dominant, additive, and recessive SNP effects.
  
  
  RESULTS
  After adjusting for known risk factors for PC, single SNP analysis revealed an association between four SNPs in NOS1 and one in the CD101 gene with PC risk. These results, however, were not replicated in a PC case-control and cohort population.
  
  
  CONCLUSIONS
  NOS1 and CD101 may be associated with a risk of PC; however, these findings did not replicate in other PC populations. Future research is needed into the possible role of NOS1 and CD101 for PC.
  
  
  CONCLUSIONS
  This research shows a lack of association between genetic variation in 102 inflammation-related genes and PC. Future research is needed into the possible role of other inflammation-related genes and PC risk.
authors.affiliation: Division of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA. reidlombardo.kaye@mayo.edu
authors.forename: Kaye M
authors.initials: KM
authors.lastname: Reid-Lombardo
authors.forename: Brooke L
authors.initials: BL
authors.lastname: Fridley
authors.forename: William R
authors.initials: WR
authors.lastname: Bamlet
authors.forename: Julie M
authors.initials: JM
authors.lastname: Cunningham
authors.forename: Michael G
authors.initials: MG
authors.lastname: Sarr
authors.forename: Gloria M
authors.initials: GM
authors.lastname: Petersen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D052248:Nitric Oxide Synthase Type I / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D015703:Antigens, CD; C093213:CD101 antigen, human; D008562:Membrane Glycoproteins; C496320:NOS1 protein, human; D052248:Nitric Oxide Synthase Type I