title: Single wall carbon nanotubes block ion passage in mechano-sensitive ion channels by interacting with extracellular domain.
abstract: Mechanosensitive ion channel transduce physical stresses to cells by the response of electro-chemicals exchange. The purpose of this study was to improve understanding of ion channel inhibition process by SWCNTs. PatchDock and FireDock results suggest that the SWCNTs interact with the extracellular domain of the ion channels. SWCNTs can be considered as the new class of ion channel inhibitors.
authors.affiliation: Sub-DIC Bioinformatics, National Institute of Technology Raipur, Chhattisgarh 492010, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Patel
authors.forename: Suchi
authors.initials: S
authors.lastname: Smita
authors.forename: Qamar
authors.initials: Q
authors.lastname: Rahman
authors.forename: Shailendra K
authors.initials: SK
authors.lastname: Gupta
authors.forename: Mukesh K
authors.initials: MK
authors.lastname: Verma
mesh_terms: D000818:Animals; D003198:Computer Simulation; D045604:Extracellular Fluid / Q000737:chemistry*; D006801:Humans; D015640:Ion Channel Gating; D008051:Lipid Bilayers / Q000737:chemistry*; D040542:Mechanotransduction, Cellular; D008954:Models, Biological; D008956:Models, Chemical; D037742:Nanotubes, Carbon / Q000737:chemistry*; D017434:Protein Structure, Tertiary
chemical_list: D008051:Lipid Bilayers; D037742:Nanotubes, Carbon