title: Lithium acetylides as alkynylating reagents for the enantioselective alkynylation of ketones catalyzed by lithium binaphtholate.
abstract: Chiral lithium binaphtholate effectively catalyzed the enantioselective alkynylation of ketones using lithium acetylide as an alkynylating agent. This is the first example of the catalytic enantioselective addition of lithium acetylide to carbonyl compounds without the aid of other metal sources.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, Japan. nakajima@gpo.kumamoto-u.ac.jp
authors.forename: Kana
authors.initials: K
authors.lastname: Tanaka
authors.forename: Kenji
authors.initials: K
authors.lastname: Kukita
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ichibakase
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kotani
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakajima
mesh_terms: D000114:Acetylene / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D009284:Naphthols / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D007659:Ketones; D009284:Naphthols; D008094:Lithium; D000114:Acetylene