title: Synthesis of a natural gamma-butyrolactone from nerylacetone by Acremonium roseum and Fusarium oxysporum cultures.
abstract: Natural gamma-butyrolactone - (4R, 5R)-5-(4'-methyl-3'pentenyl)-4-hydroxy-5-methyl-dihydrofuran-2-one (2) was isolated as the product of microbial transformation of nerylacetone (1) by fungal strains. This product was obtained as the enantiomer (+) in high yields 24% and 61% with ee=94% and 82% by the biotransformation in the cultures of Acremonium roseum AM336 and Fusarium oxysporum AM13 respectively.
authors.affiliation: Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland. anna.gliszczynska@wp.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Gliszczyńska
authors.forename: Marta
authors.initials: M
authors.lastname: Switalska
authors.forename: Joanna
authors.initials: J
authors.lastname: Wietrzyk
authors.forename: Czesław
authors.initials: C
authors.lastname: Wawrzeńczyk
mesh_terms: D015107:4-Butyrolactone / Q000737:chemistry / Q000378:metabolism*; D000096:Acetone / Q000031:analogs & derivatives* / Q000737:chemistry; D000164:Acremonium / Q000737:chemistry / Q000378:metabolism*; D001711:Biotransformation; D045744:Cell Line, Tumor; D002849:Chromatography, Gas; D004354:Drug Screening Assays, Antitumor; D005670:Fusarium / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D013778:Tetrazolium Salts; D013844:Thiazoles; D000096:Acetone; C022616:thiazolyl blue; C558323:nerylacetone; D015107:4-Butyrolactone