title: Polymorphisms of the matrix metalloproteinases associated with prostate cancer.
abstract: Prostate cancer (PCa) is the most common type of malignant tumor in Brazilian males. Single nucleotide polymorphisms (SNPs) have been demonstrated to be present in the promoter region of matrix metalloproteinase (MMP) genes and have been associated with the development and progression of some cancers. In this study, our aim was to investigate the association between the polymorphisms of MMP1, 2, 7, and 9 and susceptibility, and their correlation with the classic prognostic parameters of PCa. For genes MMP1, 2 and 9, the frequencies of the polymorphic homozygote genotypes were higher in the control group than in the PCa group (P<0.0001). We conclude that the MMP1, 2 and 9 polymorphisms are more common in the control group than in patients with PCa, and may have a protective effect in the development of this neoplasia.
authors.affiliation: Laboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil. sasareis@gmail.com.
authors.forename: Sabrina Thalita
authors.initials: ST
authors.lastname: Dos Reis
authors.forename: Fabiola Elizabeth
authors.initials: FE
authors.lastname: Villanova
authors.forename: Priscila Maria
authors.initials: PM
authors.lastname: De Andrade
authors.forename: José
authors.initials: J
authors.lastname: Pontes
authors.forename: Iran Amorim
authors.initials: IA
authors.lastname: Silva
authors.forename: Flávio Canelas
authors.initials: FC
authors.lastname: Canavez
authors.forename: Adriana
authors.initials: A
authors.lastname: Sañudo
authors.forename: Miguel
authors.initials: M
authors.lastname: Srougi
authors.forename: Kátia Ramos Moreira
authors.initials: KR
authors.lastname: Leite