title: Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses.
abstract: Double-stranded RNA (dsRNA), the genetic material for many RNA viruses, induces robust host immune responses via pattern recognition receptors, which include Toll-like receptor 3 (TLR3), retinoic acid-inducible gene-I-like receptors (RLRs) and the multi-protein NLRP3 inflammasome complex. The engagement of dsRNA receptors or inflammasome activation by viral dsRNA initiates complex intracellular signaling cascades that play essential roles in inflammation and innate immune responses, as well as the resultant development of adaptive immunity. This review focuses on signaling pathways mediated by TLR3, RLRs and the NLRP3 inflammasome, as well as the potential use of agonists and antagonists that target these pathways to treat disease.
authors.affiliation: Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, United States.
authors.forename: Man
authors.initials: M
authors.lastname: Yu
authors.forename: Stewart J
authors.initials: SJ
authors.lastname: Levine
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D053487:DEAD-box RNA Helicases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology*; D011070:Poly I-C / Q000627:therapeutic use; D012328:RNA Viruses / Q000276:immunology; D012330:RNA, Double-Stranded / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D051196:Toll-Like Receptor 3 / Q000276:immunology*
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D012330:RNA, Double-Stranded; D051196:Toll-Like Receptor 3; D053487:DEAD-box RNA Helicases; D011070:Poly I-C