title: Prenylated Polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07.
abstract: Six new prenylated polyhydroxy-p-terphenyl metabolites, named prenylterphenyllins A-C (1-3) and prenylcandidusins A-C (5-7), and one new polyhydroxy-p-terphenyl with a simple tricyclic C-18 skeleton, named 4''-dehydro-3-hydroxyterphenyllin (4), were obtained together with eight known analogues (8-15) from Aspergillus taichungensis ZHN-7-07, a root soil fungus isolated from the mangrove plant Acrostichum aureum. Their structures were determined by spectroscopic methods, and their cytotoxicity was evaluated using HL-60, A-549, and P-388 cell lines. Compounds 1 and 8 exhibited moderate activities against all three cell lines (IC50 1.53-10.90 μM), whereas compounds 4 and 6 displayed moderate activities only against the P-388 cell line (IC50 of 2.70 and 1.57 μM, respectively).
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
authors.forename: Shengxin
authors.initials: S
authors.lastname: Cai
authors.forename: Shiwei
authors.initials: S
authors.lastname: Sun
authors.forename: Huinan
authors.initials: H
authors.lastname: Zhou
authors.forename: Xianglan
authors.initials: X
authors.lastname: Kong
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D018517:Plant Roots / Q000382:microbiology; D054876:Prenylation; D043982:Rhizophoraceae / Q000382:microbiology; D013730:Terphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013730:Terphenyl Compounds