title: Necrotizing infundibulo-hypophysitis: an entity too rare to be true?
abstract: We report a young woman with sudden and severe retroorbital headache, neck pain, and a large sellar mass extending to the suprasellar cistern. A presumptive diagnosis of non-secreting pituitary macroadenoma undergoing apoplexy was made and transphenoidal surgery performed. Histopathology revealed mononuclear infiltration and marked non-hemorrhagic necrosis of the anterior pituitary consistent with a diagnosis of necrotizing infundibulo-hypophysitis. The possible pathogenesis of this rare variant of hypophysitis is discussed.
authors.affiliation: Department of Neurosurgery, University Medical Center, Georg August University, 37099, Göttingen, Germany. agutenberg@med.uni-goettingen.de
authors.forename: Angelika
authors.initials: A
authors.lastname: Gutenberg
authors.forename: Patrizio
authors.initials: P
authors.lastname: Caturegli
authors.forename: Imke
authors.initials: I
authors.lastname: Metz
authors.forename: Ramon
authors.initials: R
authors.lastname: Martinez
authors.forename: Alexander
authors.initials: A
authors.lastname: Mohr
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Brück
authors.forename: Veit
authors.initials: V
authors.lastname: Rohde
mesh_terms: D005260:Female; D006801:Humans; D009336:Necrosis / Q000175:diagnosis*; D010900:Pituitary Diseases / Q000175:diagnosis*; D010904:Pituitary Gland, Posterior / Q000473:pathology