title: Cells as factories for humanized encapsulation.
abstract: Biocompatibility is of paramount importance for drug delivery, tumor labeling, and in vivo application of nanoscale bioprobes. Until now, biocompatible surface processing has typically relied on PEGylation and other surface coatings, which, however, cannot minimize clearance by macrophages or the renal system but may also increase the risk of chemical side effects. Cell membranes provide a generic and far more natural approach to the challenges of encapsulation and delivery in vivo. Here we harness for the first time living cells as "factories" to manufacture cell membrane capsules for encapsulation and delivery of drugs, nanoparticles, and other biolabels. Furthermore, we demonstrate that the built-in protein channels of the new capsules can be utilized for controlled release of encapsulated reagents.
authors.affiliation: Max Planck Institute of Colloids and Interfaces, D-14424, Potsdam, Germany.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Mao
authors.forename: Regis
authors.initials: R
authors.lastname: Cartier
authors.forename: Anja
authors.initials: A
authors.lastname: Hohl
authors.forename: Maura
authors.initials: M
authors.lastname: Farinacci
authors.forename: Anca
authors.initials: A
authors.lastname: Dorhoi
authors.forename: Tich-Lam
authors.initials: TL
authors.lastname: Nguyen
authors.forename: Paul
authors.initials: P
authors.lastname: Mulvaney
authors.forename: John
authors.initials: J
authors.lastname: Ralston
authors.forename: Stefan H E
authors.initials: SH
authors.lastname: Kaufmann
authors.forename: Helmuth
authors.initials: H
authors.lastname: Möhwald
authors.forename: Dayang
authors.initials: D
authors.lastname: Wang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002214:Capsules; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D016503:Drug Delivery Systems; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D008856:Microscopy, Fluorescence / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D002214:Capsules; D011092:Polyethylene Glycols