title: Association between polymorphism rs6983267 and gastric cancer risk in Chinese population.
abstract: OBJECTIVE
  To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk.
  
  
  METHODS
  A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer.
  
  
  RESULTS
  The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively).
  
  
  CONCLUSIONS
  This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.
authors.affiliation: Department of Gastroenterology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
authors.forename: Jing
authors.initials: J
authors.lastname: Fang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Hai-Hui
authors.initials: HH
authors.lastname: Sheng
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
authors.forename: Hai-Na
authors.initials: HN
authors.lastname: Chai
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
authors.forename: Ke-Hao
authors.initials: KH
authors.lastname: Zhang
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Yang
authors.forename: Heng-Jun
authors.initials: HJ
authors.lastname: Gao
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*