title: Transcatheter patch occlusion of ventricular septal defect in Down syndrome.
abstract: Closure of perimembranous ventricular septal defects in patients with Down syndrome, either surgically or by Amplatzer occluders, carries a high risk of complete heart block. We report 5 closures using the transcatheter patch, a wireless bioabsorbable device without any reported heart block to date. The median defect size was 11 mm. Small devices were used in 4 patients and a medium size in 1. The patch was released after 48 hours in 3 patients and immediately in the other 2. Of the 5 patients, 3 were followed up for >5 years and 2 for 1 year. None of these patients had atrioventricular block during their follow-up. In conclusion, the transcatheter patch might be superior in terms of cardiac conduction system protection in patients with Down syndrome after ventricular septal defect closure.
authors.affiliation: Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Zeinaloo
authors.forename: Benjamine
authors.initials: B
authors.lastname: Macuil
authors.forename: Keyhan Sayadpour
authors.initials: KS
authors.lastname: Zanjani
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Sideris
mesh_terms: D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000473:pathology / Q000628:therapy*; D006801:Humans; D011140:Polyurethanes; D019736:Prostheses and Implants
chemical_list: D011140:Polyurethanes