title: Solvent-free or low-solvent large-scale preparation of chloropyrimidine and analogues.
abstract: Chloropyrimidine or other N-containing aromatic heterocyclic analogues can be efficiently prepared from the corresponding hydroxylated precursors under solvent-free or low-solvent conditions with equimolar or less chlorinating reagents. This high-yielding protocol allows successful preparations of multigram and kilogram batches of these important synthetic intermediates.
authors.affiliation: College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201600, China. zhihuasun@sues.edu.cn
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Sun
authors.forename: Han
authors.initials: H
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Wen
authors.forename: Ya
authors.initials: Y
authors.lastname: Li
authors.forename: Erkang
authors.initials: E
authors.lastname: Fan
mesh_terms: D055772:Green Chemistry Technology / Q000379:methods*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: C542779:2-chloropyrimidine; D011743:Pyrimidines; D012997:Solvents