title: Lithothamnin A, the first bastadin-like metabolite from the red alga Lithothamnion fragilissimum.
abstract: Lithothamnin A (1) is a new bastadin-like metabolite and represents the first report of this class of molecules from the red alga Lithothamnion fragilissimum. Lithothamnin A contains several novel structural features that distinguish it from other bastadins. These unique structural features include novel aromatic substitution patterns and the presence of a meta-meta linkage between aromatic rings, in addition to the meta-para linkage seen in the bastadins. Lithothamnin A is modestly cytotoxic in a panel of six human tumor cell lines.
authors.affiliation: Molecular Targets Laboratory, Molecular Discovery Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702-1202, United States.
authors.forename: Albert W W
authors.initials: AW
authors.lastname: Van Wyk
authors.forename: Karina M
authors.initials: KM
authors.lastname: Zuck
authors.forename: Tawnya C
authors.initials: TC
authors.lastname: McKee
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D055768:Halogenated Diphenyl Ethers; D006801:Humans; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D055768:Halogenated Diphenyl Ethers; D010456:Peptides, Cyclic; C560171:lithothamnin A