title: Formulation and evaluation of domperidone loaded mineral oil entrapped emulsion gel (MOEG) buoyant beads.
abstract: Alginate based mineral oil entrapped emulsion gel (MOEG) buoyant beads of domperidone were prepared by emulsion gelation technique. The prepared beads were evaluated for particle size, surface morphology, buoyancy, actual drug content and entrapment efficiency. Effect of different oils (castor oil, olive oil and linseed oil) and oil concentrations (10%, 15% and 20%, w/w) on uniformity, homogeneity and integrity of the beads was also studied. Density of the formulated beads was found to be ranging between 0.101 and 0.182 g/cm3. The results of the in vitro drug release indicated that linseed oil showed to be good release retardant compared to castor oil and olive oil. Moreover, the beads formulated using 15%, w/w linseed oil were more uniform in shape, exhibited maximum buoyancy and minimal oil leakage. Diffusion exponent (n) value varied from 0.4855 to 0.7710 indicating anomalous drug release behavior involving swelling, diffusion and/or erosion of the polymer matrix.
authors.affiliation: Chitkara College of Pharmacy, Chandigarh-Patiala National Highway, Rajpura-140401, Patiala, Punjab, India. inderbirsingh2906@gmail.com
authors.forename: Inderbir
authors.initials: I
authors.lastname: Singh
authors.forename: Pradeep
authors.initials: P
authors.lastname: Kumar
authors.forename: Harinderjit
authors.initials: H
authors.lastname: Singh
authors.forename: Malvika
authors.initials: M
authors.lastname: Goyal
authors.forename: Vikas
authors.initials: V
authors.lastname: Rana
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002368:Castor Oil / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D004294:Domperidone / Q000737:chemistry*; D018492:Dopamine Antagonists / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D004655:Emulsions; D005782:Gels; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007700:Kinetics; D008043:Linseed Oil / Q000737:chemistry; D008899:Mineral Oil / Q000737:chemistry*; D000069463:Olive Oil; D010316:Particle Size; D010938:Plant Oils / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000464:Alginates; D018492:Dopamine Antagonists; D004337:Drug Carriers; D004655:Emulsions; D005782:Gels; D006603:Hexuronic Acids; D000069463:Olive Oil; D010938:Plant Oils; D004294:Domperidone; D008043:Linseed Oil; D002368:Castor Oil; D008899:Mineral Oil; D020723:Glucuronic Acid