title: Granulomatous colitis of boxer dogs.
abstract: Granulomatous colitis (GC) is a rare, breed-specific inflammatory bowel disease of young Boxer dogs. GC has been refractory to treatment and associated with high mortality rates, but culture-independent molecular analysis has transformed therapy and prognosis by uncovering a correlation between GC and Escherichia coli invasion within colonic mucosal macrophages. GC-associated invasive E coli are similar to a newly identified E coli pathotype, "adherent and invasive E coli," that are increasingly associated with Crohn's disease in humans. Successful treatment of GC requires antimicrobials that are effective against E coli and penetrate intracellularly. Enrofloxacin is widely regarded as the antibiotic of choice.
authors.affiliation: Department of Veterinary Clinical Sciences, Cornell University, Tower Road, Ithaca, NY 14853-6401, USA. mdc57@cornell.edu
authors.forename: Melanie
authors.initials: M
authors.lastname: Craven
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Mansfield
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Simpson
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D003424:Crohn Disease / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D004285:Dogs; D004926:Escherichia coli / Q000302:isolation & purification / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy / Q000662:veterinary*; D020022:Genetic Predisposition to Disease; D008264:Macrophages / Q000382:microbiology