title: Serum levels of the adipokine chemerin are increased in preeclampsia during and 6 months after pregnancy.
abstract: Preeclampsia is a serious cardiovascular complication in pregnancy which is associated with an increased future metabolic and cardiovascular risk for mother and newborn. Recently, chemerin was introduced as a novel adipokine inducing insulin resistance in vitro and in vivo. In the current study, we investigated serum concentrations of chemerin by ELISA in control and preeclampsia patients during pregnancy (
  
  
  METHODS
  n=37, preeclampsia: n=37) and 6 months after delivery (
  
  
  METHODS
  n=35, preeclampsia: n=36). Furthermore, the association between chemerin and markers of renal function, glucose and lipid metabolism, as well as inflammation was studied in pregnant patients. Median maternal chemerin concentrations were significantly elevated in preeclampsia patients (249.5 [range: 123.1-366.9] μg/l) as compared to controls (204.8 [138.5-280.8] μg/l) (p<0.001). Furthermore, chemerin serum levels positively correlated with blood pressure, creatinine, free fatty acids, cholesterol, triglycerides (TG), leptin, adiponectin, and C-reactive protein in univariate analyses. In multivariate analyses, TG and leptin remained independently associated with circulating chemerin. Interestingly, median chemerin concentrations 6 months after delivery remained significantly higher in former preeclampsia patients (196.0 [119.8-368.7] μg/l) as compared to controls (152.2 [102.8-216.4] μg/l). Taken together, maternal chemerin serum concentrations are significantly increased in preeclampsia during and after pregnancy. Furthermore, TG and leptin are independent predictors of circulating chemerin during pregnancy.
authors.affiliation: University of Leipzig, Department of Obstetrics, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Stepan
authors.forename: Anne
authors.initials: A
authors.lastname: Philipp
authors.forename: Ingo
authors.initials: I
authors.lastname: Roth
authors.forename: Susan
authors.initials: S
authors.lastname: Kralisch
authors.forename: Alexander
authors.initials: A
authors.lastname: Jank
authors.forename: Wiebke
authors.initials: W
authors.lastname: Schaarschmidt
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lössner
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kratzsch
authors.forename: Matthias
authors.initials: M
authors.lastname: Blüher
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.forename: Mathias
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D000293:Adolescent; D000328:Adult; D018925:Chemokines / Q000097:blood*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D015999:Multivariate Analysis; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human