title: Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system.
abstract: Inflammatory processes are central to reproductive events including ovulation, menstruation, implantation and labour, while inflammatory dysregulation is a feature of numerous reproductive pathologies. In recent years, there has been much research into the endogenous mechanisms by which inflammatory reactions are terminated and tissue homoeostasis is restored, a process termed resolution. The identification and characterisation of naturally occurring pro-resolution mediators including lipoxins and annexin A1 has prompted a shift in the field of anti-inflammation whereby resolution is now observed as an active process, triggered as part of a normal inflammatory response. This review will address the process of resolution, discuss available evidence for expression of pro-resolution factors in the reproductive tract and explore possible roles for resolution in physiological reproductive processes and associated pathologies.
authors.affiliation: MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.
authors.forename: James L
authors.initials: JL
authors.lastname: Hutchinson
authors.forename: Shalini P
authors.initials: SP
authors.lastname: Rajagopal
authors.forename: Kurt J
authors.initials: KJ
authors.lastname: Sales
authors.forename: Henry N
authors.initials: HN
authors.lastname: Jabbour
mesh_terms: D000818:Animals; D017305:Annexin A1 / Q000378:metabolism; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015777:Eicosanoids / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D005836:Genitalia, Female / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D044042:Receptors, Formyl Peptide / Q000378:metabolism; D044067:Receptors, Lipoxin / Q000378:metabolism; D012098:Reproduction; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D017305:Annexin A1; D000893:Anti-Inflammatory Agents; D015777:Eicosanoids; C105101:FPR2 protein, human; D015525:Fatty Acids, Omega-3; D005938:Glucocorticoids; D044042:Receptors, Formyl Peptide; D044067:Receptors, Lipoxin