title: Severe hemolytic crisis after ceftriaxone administration.
abstract: Ceftriaxone is a commonly administered antibiotic, and hemolytic crisis is a dangerous potential adverse event. We describe 2 children with sickle cell disease who developed severe hemolytic crisis after ceftriaxone administration. Both subsequently demonstrated the presence of anticeftriaxone antibodies that may have been responsible for the massive hemolysis.
authors.affiliation: Division of Emergency Medicine, Children’s Hospital of Philadelphia, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA. goyal@email.chop.edu
authors.forename: Monika
authors.initials: M
authors.lastname: Goyal
authors.forename: Aaron
authors.initials: A
authors.lastname: Donoghue
authors.forename: Sandra
authors.initials: S
authors.lastname: Schwab
authors.forename: Nicole
authors.initials: N
authors.lastname: Hasbrouck
authors.forename: Soreena
authors.initials: S
authors.lastname: Khojasteh
authors.forename: Kevin
authors.initials: K
authors.lastname: Osterhoudt
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002443:Ceftriaxone / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006461:Hemolysis; D006801:Humans; D008297:Male; D012720:Severity of Illness Index
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone