title: Cytotoxicity and photocytotoxicity of structure-defined water-soluble C60/micelle supramolecular nanoparticles.
abstract: Well-defined, water-soluble C(60)/micelle hierarchical colloids with varied amounts of C(60) sitting on the surface of micellar cores were prepared via the self-assembly of PS-b-PDMA block copolymer micelles and C(60). The composites can generate a significant amount of reactive oxygen upon irradiation with red light. Cell studies showed that the colloids were either strongly associated with, or internalized by, the cells after 2 h incubation, but did not show obvious toxicity in the dark. In contrast, efficient cell killing was observed when the colloid-incubated cells were exposed to red light. This indicates that the supramolecular colloids are promising as photosensitizers for photodynamic cancer therapy.
authors.affiliation: School of Chemistry, University of Leeds, Leeds, UK.
authors.forename: Tanapak
authors.initials: T
authors.lastname: Metanawin
authors.forename: Tian
authors.initials: T
authors.lastname: Tang
authors.forename: Rongjun
authors.initials: R
authors.lastname: Chen
authors.forename: David
authors.initials: D
authors.lastname: Vernon
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Wang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D037741:Fullerenes; D008823:Micelles; D017319:Photosensitizing Agents; D014867:Water; C069837:fullerene C60