title: Towards the design of combination therapy for the treatment of enterovirus infections.
abstract: We report here on a comparative study of the activity of 10 enterovirus inhibitors against poliovirus 1, enterovirus 71 and human rhinovirus 14. Three of the selected molecules (Pleconaril, BTA-798 and V-073) are in clinical development. The in vitro antiviral activity of pairwise combinations of inhibitors indicated that most combinations resulted in an additive to slightly synergistic antiviral activity. However, the combination of ribavirin with a nucleoside polymerase inhibitor resulted in a pronounced antagonistic effect.
authors.affiliation: Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
authors.forename: Hendrik Jan
authors.initials: HJ
authors.lastname: Thibaut
authors.forename: Pieter
authors.initials: P
authors.lastname: Leyssen
authors.forename: Gerhard
authors.initials: G
authors.lastname: Puerstinger
authors.forename: Alexandra
authors.initials: A
authors.lastname: Muigg
authors.forename: Johan
authors.initials: J
authors.lastname: Neyts
authors.forename: Armando Mirko
authors.initials: AM
authors.lastname: De Palma
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004770:Enterovirus / Q000187:drug effects* / Q000502:physiology; D004769:Enterovirus Infections / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000998:Antiviral Agents