title: Review of pharmaceutical applications of N-methyl-2-pyrrolidone.
abstract: N-Methyl-2-pyrrolidone (NMP) or Pharmasolve is very strong solubilizing agent and it has important applications in different fields of industry. This review presents NMP physicochemical characteristics, application especially in pharmaceutical sciences, pharmacokinetic and toxicity. Characteristics of NMP such as physicochemical properties, solubilization efficacy, toxicity and adverse effects were compared with other common solvents used in the pharmaceutical industries. This review reveals that NMP is an acceptable pharmaceutical solvent and its efficacy, toxicity, and side effects are comparable with other common solvent.
authors.affiliation: Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. ajouyban@hotmail.com
authors.forename: Abolghasem
authors.initials: A
authors.lastname: Jouyban
authors.forename: Mohammad A A
authors.initials: MA
authors.lastname: Fakhree
authors.forename: Ali
authors.initials: A
authors.lastname: Shayanfar
mesh_terms: D000818:Animals; D005079:Excipients / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry; D011760:Pyrrolidinones / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D012995:Solubility; D012997:Solvents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D005079:Excipients; D004364:Pharmaceutical Preparations; D011760:Pyrrolidinones; D012997:Solvents; C038678:N-methylpyrrolidone