title: Isoprenylated cyclohexanoids from the basidiomycete Hexagonia speciosa.
abstract: Nine oxygenated cyclohexanoids, speciosins L-T (1-9) as well as a 5H-furan-2-one metabolite, 5'-O-acetylaporpinone A (10), together with known analogs, speciosins A, B, D, E, F, I and K (11-17), and aporpinone A (18), were isolated from a scale-up cultures of the basidiomycete Hexagonia speciosa. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR. Speciosin B (12) showed significant cytotoxicity against several tumor cell lines with IC50 values in the range 0.23-3.30 μM.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Meng-Yuan
authors.initials: MY
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D003511:Cyclohexanols / Q000737:chemistry* / Q000302:isolation & purification; D003512:Cyclohexanones / Q000737:chemistry* / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006844:Hydrocarbons, Cyclic / Q000737:chemistry* / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D054876:Prenylation
chemical_list: D000970:Antineoplastic Agents; D003511:Cyclohexanols; D003512:Cyclohexanones; D006844:Hydrocarbons, Cyclic; C000596531:speciosin B