title: Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis.
abstract: BACKGROUND
  The clinical consequences of chronic Stenotrophomonas maltophilia infection in cystic fibrosis (CF) patient are still unclear.
  
  
  METHODS
  All patients treated in the Copenhagen CF centre (N=278) from 1 January 2008 to 31 December 2009 were included. Each patient chronically infected with S. maltophilia for at least 2 years without any other chronic Gram-negative infection were matched to two non-infected CF controls.
  
  
  RESULTS
  Twenty-one patients were chronically infected with S. maltophilia during the 2-year study period. Fifteen were infected for at least 2 years. The patients in the S. maltophilia group had a steeper decline (-3.2%/year vs. -0.3%/year) in FEV(1) compared to the non-infected CF controls (P=0.03). The rate of decline was the same as observed 3 years before the patients became chronically infected.
  
  
  CONCLUSIONS
  Chronic infection with S. maltophilia does not lead to a steeper decline in lung function when compared to the period before chronic infection.
authors.affiliation: Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. christinadalboege@gmail.com
authors.forename: C S
authors.initials: CS
authors.lastname: Dalbøge
authors.forename: C R
authors.initials: CR
authors.lastname: Hansen
authors.forename: T
authors.initials: T
authors.lastname: Pressler
authors.forename: N
authors.initials: N
authors.lastname: Høiby
authors.forename: H K
authors.initials: HK
authors.lastname: Johansen
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015331:Cohort Studies; D060085:Coinfection; D003550:Cystic Fibrosis / Q000382:microbiology* / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000382:microbiology / Q000503:physiopathology*; D012129:Respiratory Function Tests; D020615:Stenotrophomonas maltophilia / Q000276:immunology / Q000302:isolation & purification*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial