title: Closing in on the Hsp90 chaperone-client relationship.
abstract: The molecular chaperone Hsp90 regulates the activity and stability of a set of client proteins. Despite progress in understanding its mechanism, the interaction of Hsp90 with clients has remained enigmatic. Now, in a recent issue of Molecular Cell, Street and coworkers present results that integrate the client in the Hsp90 chaperone cycle.
authors.affiliation: Center for Integrated Protein Science CIPSM and Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany. klaus.richter@tum.de
authors.forename: Klaus
authors.initials: K
authors.lastname: Richter
authors.forename: Johannes
authors.initials: J
authors.lastname: Buchner