title: [Photochemical inactivation of pathogens in platelets and plasma: five years of clinical use in routine and hemovigilance. Towards a change of paradigm in transfusion safety].
abstract: The transfusion of labile blood products is vital and essential for patients in absence of alternative treatment. Patients and doctors have always feared transfusion-transmitted infections by blood, blood components and blood-derived drugs. Photochemical inactivation of platelet concentrates and plasma, using a technique associating amotosalen and UVA, has been used for five years in a French region for the whole population and a large spectrum of patients, with efficacy and safety. It would seem wise to introduce labile blood products, submitted to pathogen inactivation by a technique already approved by a regulatory agency and not to wait for a perfect system including red blood cells concentrates. Universal implementation of pathogen inactivation in labile blood products is a major and key step to improve safety against infection in transfusion.
authors.affiliation: Établissement français du sang Alsace, 10, rue Spielmann, BP 36, 67065 Strasbourg cedex, France. jeanpierre.cazenave@efs-alsace.fr
authors.forename: J-P
authors.initials: JP
authors.lastname: Cazenave
mesh_terms: D001771:Blood Banks / Q000592:standards; D016913:Blood Component Transfusion / Q000009:adverse effects / Q000592:standards*; D001792:Blood Platelets / Q000187:drug effects / Q000382:microbiology / Q000469:parasitology / Q000528:radiation effects / Q000821:virology; D058731:Blood Safety / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends; D017848:Blood-Borne Pathogens / Q000187:drug effects* / Q000528:radiation effects*; D002986:Clinical Trials as Topic; D005602:France; D011564:Furocoumarins / Q000494:pharmacology; D006801:Humans; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000494:pharmacology*; D010949:Plasma / Q000187:drug effects / Q000382:microbiology / Q000469:parasitology / Q000528:radiation effects / Q000821:virology; D017713:Platelet Transfusion / Q000009:adverse effects / Q000592:standards; D012955:Societies, Medical / Q000592:standards; D014466:Ultraviolet Rays; D038301:Virus Inactivation / Q000187:drug effects / Q000528:radiation effects
chemical_list: D011564:Furocoumarins; D017319:Photosensitizing Agents; C118577:amotosalen