title: Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities.
abstract: In order to study the SAR of 5(6)-dihydro-OSW-1, eight 15(α)β-O-glycosyl analogs (26-33) carrying three kinds of disaccharides including [β-d-Xylp-(1-3)-α-l-Arap], [β-d-Xylp-(1-4)-α-l-Arap] and [α-l-Rhap-(1-2)-(α)β-d-Glcp] were designed and synthesized. Their in vitro antitumor activities were tested by the standard MTT assay which disclosed that compound 33 (IC(50)=0.28-0.52 μM) showed potential antitumor activities.
authors.affiliation: Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Peking 100050, PR China.
authors.forename: Yuyao
authors.initials: Y
authors.lastname: Guan
authors.forename: Dan
authors.initials: D
authors.lastname: Zheng
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Haixing
authors.initials: H
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yan
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
authors.forename: Pingping
authors.initials: P
authors.lastname: She
authors.forename: Pingsheng
authors.initials: P
authors.lastname: Lei
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002783:Cholestenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004187:Disaccharides / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002783:Cholestenones; D004187:Disaccharides; D012503:Saponins; C106408:OSW 1