title: Selective anticancer activity of β-lactams derived from polyaromatic compound.
abstract: Currently available anticancer drugs are cytotoxic to normal as well as to neoplastic cells, therefore the synthesis of β-lactams as new and novel anticancer agents is extremely significant. We previously developed synthetic methods for the preparation of β-lactams and anticancer agents resulting from polyaromatic amines. There have also been reports on the synthesis and biological evaluation of novel racemic β-lactams as anticancer agents. In cell cycle analysis, these compounds demonstrated a G2 blockage against sensitive tumor cell lines. In the present study, useful and selective biological activities of chrysene β-lactams are described.
authors.affiliation: Department of Chemistry, The University of Texas Pan American, Edinburg, TX 78539, USA. banik@panam.edu.
authors.forename: Bimal K
authors.initials: BK
authors.lastname: Banik
authors.forename: Frederick F
authors.initials: FF
authors.lastname: Becker