title: A pediatric case of cardiomyopathy induced by inappropriate sinus tachycardia: efficacy of ivabradine.
abstract: We report the case of a 16-year-old boy with cardiomyopathy induced by inappropriate sinus tachycardia (IST). The patient was resistant to treatment with conventional rate-decreasing medications. Therapy with the selective sinus node I(f) current inhibitor ivabradine was started. After 3 months of ivabradine therapy, an improvement in ejection fraction and a successful decrease in heart rate were observed. No side effects occurred. We suggest that ivabradine, currently used to treat stable angina, could be considered as a second-line treatment in patients with symptomatic and refractory IST.
authors.affiliation: Department of Cardiology, Monaldi Hospital, Second University of Naples, Naples, Italy. ema.romeo@alice.it
authors.forename: Emanuele
authors.initials: E
authors.lastname: Romeo
authors.forename: Nicola
authors.initials: N
authors.lastname: Grimaldi
authors.forename: Berardo
authors.initials: B
authors.lastname: Sarubbi
authors.forename: Michele
authors.initials: M
authors.lastname: D'Alto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Santarpia
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Scognamiglio
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Russo
authors.forename: Raffaele
authors.initials: R
authors.lastname: Calabrò
mesh_terms: D000293:Adolescent; D001552:Benzazepines / Q000008:administration & dosage / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000037:antagonists & inhibitors; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory; D005500:Follow-Up Studies; D006801:Humans; D000077550:Ivabradine; D008297:Male; D013616:Tachycardia, Sinus / Q000150:complications* / Q000175:diagnosis
chemical_list: D001552:Benzazepines; D054815:Cyclic Nucleotide-Gated Cation Channels; D000077550:Ivabradine