title: [Sodium bicarbonate to slow the progression of chronic kidney disease].
abstract: Metabolic acidosis is a prevalent complication in moderate and late stages of chronic kidney disease (CKD). It is established that the correction of metabolic acidosis may improve metabolic bone disorders and protein degradation in the skeletal muscle, two characteristic complications of patients with advanced CKD. In the last 18 months, three randomized controlled trials have drawn the attention on a novel indication to correct metabolic acidosis in these patients, i.e., halting CKD progression. These data show that sodium bicarbonate, a cheap and easily manageable treatment, may delay the progression of CKD and the need of a renal replacement therapy such as dialysis or kidney transplantation.
authors.affiliation: Service de néphrologie, Département de médecine interne, CHUV, Lausanne.
authors.forename: A
authors.initials: A
authors.lastname: Rossier
authors.forename: R
authors.initials: R
authors.lastname: Bullani
authors.forename: M
authors.initials: M
authors.lastname: Burnier
authors.forename: D
authors.initials: D
authors.lastname: Teta
mesh_terms: D000138:Acidosis / Q000188:drug therapy* / Q000209:etiology; D002021:Buffers; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D017693:Sodium Bicarbonate / Q000627:therapeutic use*
chemical_list: D002021:Buffers; D017693:Sodium Bicarbonate