title: Development and evolution: two determinants of cortical connectivity.
abstract: The production of genotypic and phenotypic diversity (differentiation) is the final outcome of both development and evolution, of nervous systems and of their components. Cortical axons, in particular, differentiate into a variety of phenotypes which are responsible for computational transformations of messages exchanged among neurons. One aspect of this differentiation concerns axon diameters whose diversity in development, but also within and across species, is enhanced by the addition of a relatively small proportion of thicker axons to some axonal pathways. This, combined with differences in the length of pathways and in brain volumes, has rescaled and expanded the temporal range of interneuronal communication. In both development and evolution, this and other aspects of axonal phenotypes, namely the structure and distribution of axonal arbors, differentiate by the combined action of cell intrinsic (genetic) variation, overproduction, and selection by the environment.
authors.affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Giorgio.Innocenti@ki.se
authors.forename: Giorgio M
authors.initials: GM
authors.lastname: Innocenti
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D005075:Biological Evolution; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D009024:Morphogenesis / Q000502:physiology; D010641:Phenotype