title: Age-related macular degeneration and the other double helix. The Cogan Lecture.
abstract: The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNAs (dsRNAs) in neovascular AMD and cytotoxic functions for endogenous dsRNAs in atrophic AMD. These findings provide new insights into the pathogenesis and therapy of both forms of AMD.
authors.affiliation: Department of Ophthalmology and Vision Sciences, University of Kentucky, 740 S. Limestone Street, Lexington, KY 40536-0284, USA. jamba2@email.uky.edu
authors.forename: Jayakrishna
authors.initials: J
authors.lastname: Ambati
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D001363:Awards and Prizes; D020256:Choroidal Neovascularization / Q000628:therapy*; D005431:Florida; D049674:History, 21st Century; D006801:Humans; D008268:Macular Degeneration / Q000628:therapy; D009885:Ophthalmology / Q000266:history; D012330:RNA, Double-Stranded / Q000627:therapeutic use*; D034741:RNA, Small Interfering / Q000627:therapeutic use; D012958:Societies, Scientific
chemical_list: D020533:Angiogenesis Inhibitors; D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering