title: Acute juvenile cataract in newly diagnosed type 1 diabetic patients: a description of six cases.
abstract: Cataract represents one of the most frequent eye complications in type 1 and type 2 patients; contrarily, acute cataract in young diabetic patients occurs very rarely. The aim of this study was to describe six cases of acute cataract in adolescents at the onset of type 1 diabetes. Eight hundred and twenty-six patients with type 1 diabetes were retrospectively studied. A multivariate analysis was applied to verify the weight of the following laboratory findings taken on admission (independent variables): glycemia, glycated hemoglobin (HbA1c), pH, base excess (BE),and on the occurrence of cataract (dependent variable). Six patients (0.7%) presented with acute lens opacities. Cataract development was significantly correlated with HbA1c and glycemia. The relative risk increases about twice for each percentage point from 12.8 to 14.1% of HbA1c; glycemic blood levels represent a moderate risk factor for cataractogenesis. Ketoacidosis and BE were not significantly correlated.
authors.affiliation: Department of Pediatrics, Second University of Naples, Naples, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Iafusco
authors.forename: Francesco
authors.initials: F
authors.lastname: Prisco
authors.forename: Mario R
authors.initials: MR
authors.lastname: Romano
authors.forename: Roberto
authors.initials: R
authors.lastname: Dell'omo
authors.forename: Teodosio
authors.initials: T
authors.lastname: Libondi
authors.forename: Ciro
authors.initials: C
authors.lastname: Costagliola
mesh_terms: D000293:Adolescent; D000328:Adult; D002386:Cataract / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult