title: Fatal acute pancreatitis associated with reactive AA amyloidosis in rheumatoid arthritis with end-stage renal disease: a report of three cases.
abstract: We report three cases of fatal pancreatitis associated with systemic AA amyloidosis in rheumatoid arthritis (RA). All of the patients showed end-stage renal failure, and hemodialysis was introduced during the course of treatment. Autopsy was performed on two of the three patients, and this revealed amyloid deposition on the vascular walls in the pancreas. It was strongly suggested that the acute pancreatitis in all three patients was attributable to deposition of amyloid in vascular and pancreatic tissues. Acute pancreatitis is considered to be a rare complication of end-stage amyloidosis associated with RA, and is frequently fatal. It is important to treat RA patients intensively to avoid such deposition of amyloid.
authors.affiliation: Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Japan. kurodat@med.niigata-u.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kuroda
authors.forename: Hiroe
authors.initials: H
authors.lastname: Sato
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Wada
authors.forename: Shuichi
authors.initials: S
authors.lastname: Murakami
authors.forename: Takako
authors.initials: T
authors.lastname: Saeki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakano
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
mesh_terms: D000208:Acute Disease; D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000150:complications*; D001344:Autopsy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000628:therapy; D008875:Middle Aged; D010179:Pancreas / Q000098:blood supply / Q000378:metabolism; D010195:Pancreatitis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006435:Renal Dialysis; D000685:Serum Amyloid A Protein / Q000378:metabolism
chemical_list: D000685:Serum Amyloid A Protein