title: A review of sodium oxybate and baclofen in the treatment of sleep disorders.
abstract: Studies examining GABA(B) receptor agonists have reported effects on sleep including decreased sleep onset latency (SOL), increased sleep consolidation and increases in slow wave sleep (SWS). γ-hydroxybutyrate (GHB) is proposed to act as a GABA(B) receptor agonist; however, the mechanism of action of GHB is controversial. In addition, the GABA(B) receptor agonist, baclofen, has also been proposed to exert similar effects on sleep. The aim of this paper is to provide a review of the human clinical studies of sodium oxybate and baclofen regarding sleep and the treatment of sleep disorders including narcolepsy and insomnia, as well as other disorders involving disrupted sleep such as fibromyalgia.
authors.affiliation: Stanford Sleep Medicine Center, Redwood City, CA 94063-5704, USA. mbrown8@stanford.edu
authors.forename: Mark A
authors.initials: MA
authors.lastname: Brown
authors.forename: Christian
authors.initials: C
authors.lastname: Guilleminault
mesh_terms: D000818:Animals; D001418:Baclofen / Q000494:pharmacology / Q000627:therapeutic use*; D058786:GABA-B Receptor Agonists / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009290:Narcolepsy / Q000188:drug therapy / Q000378:metabolism; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy / Q000378:metabolism; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000378:metabolism; D012978:Sodium Oxybate / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D058786:GABA-B Receptor Agonists; D012978:Sodium Oxybate; D001418:Baclofen