title: [Evaluation of influencing factors and different repair mechanism of tympanic membrane perforations].
abstract: OBJECTIVE
  Evaluation of different repair mechanism and influencing factors for Prognosis of tympanic membrane perforations.
  
  
  METHODS
  One hundred and twelve female patients of tympanic membrane perforations were randomly divided into two groups: control group (natural repair group) and treatment group (gelatin sponge patch bonded repair group). The perforation healing were dynamically observed in two groups by endoscope.
  
  
  RESULTS
  The result show that low, medium and high perforations healing rates were 100.00%, 90.48%, 93.33%. The healing time of low, medium and high was (9.0 +/- 2.8) d, (13.0 +/- 2.6) d, (22.0 +/- 4.7) d, the epithelial layer reverse growth in 5 cases. The result show that low, medium and high perforations healing rates were 91.67%, 95.24%, 84.62%. The healing time of low, medium and high was (11.0 +/- 3.7) d, (24.0 +/- 3.8) d, (36.0 +/- 2.1) d, 2 cases were undergone surgeries.
  
  
  CONCLUSIONS
  There are differences in repair mechanism between natural repair and patch bonded repair patch bonded repair can promote granulation hyperplasia, it can help recovering and lessening the patient's conductive hearing loss and occasional tinnitus. granulation hyperplasia and the healing time is closely related. The epithelial layer reverse growth may affect the healing of tympanic membrane perforation.
authors.affiliation: Department of Otolaryngology, the Central Hospital of Yiwu, Yiwu, 322000, China. louzhengcai@yahoo.com.cn
authors.forename: Zhengcai
authors.initials: Z
authors.lastname: Lou
authors.forename: Yunxing
authors.initials: Y
authors.lastname: Hu
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Huaying
authors.initials: H
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D018058:Tympanic Membrane Perforation / Q000209:etiology / Q000628:therapy*; D014945:Wound Healing; D055815:Young Adult