title: Lipid bilayer reorganization under extreme pH conditions.
abstract: Supported lipid bilayers containing phosphatidylcholine headgroups are observed to undergo reorganization from a 2D fluid, lipid bilayer assembly into an array of complex 3D structures upon exposure to extreme pH environments. These conditions induce a combination of molecular packing and electrostatic interactions that can create dynamic morphologies of highly curved lipid membrane structures. This work demonstrates that fluid, single-component lipid bilayer assemblies can create complex morphologies, a phenomenon typically only associated with lipid bilayers of mixed composition.
authors.affiliation: Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, New Mexico 87185, United States. mgoertz@sandia.gov
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Goertz
authors.forename: Nikita
authors.initials: N
authors.lastname: Goyal
authors.forename: Gabriel A
authors.initials: GA
authors.lastname: Montano
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Bunker
mesh_terms: D006863:Hydrogen-Ion Concentration; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D008560:Membrane Fluidity; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D008051:Lipid Bilayers; D008565:Membrane Proteins