title: Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City.
abstract: BACKGROUND
  Recent time-series studies have indicated that both cardiovascular disease (CVD)mortality and hospitalizations are associated with particulate matter (PM). However, seasonal patterns of PM associations with these outcomes are not consistent, and PM components responsible for these associations have not been determined. We investigated this issue in New York City (NYC), where PM originates from regional and local combustion sources.
  
  
  OBJECTIVE
  In this study, we examined the role of particulate matter with aerodynamic diameter ≤ 2.5 µm (PM(2.5)) and its key chemical components on both CVD hospitalizations and on mortality in NYC.
  
  
  METHODS
  We analyzed daily deaths and emergency hospitalizations for CVDs among persons ≥ 40 years of age for associations with PM(2.5), its chemical components, nitrogen dioxide (NO(2)), carbon monoxide, and sulfur dioxide for the years 2000-2006 using a Poisson time-series model adjusting for temporal and seasonal trends, temperature effects, and day of the week. We estimated excess risks per interquartile-range increases at lags 0 through 3 days for warm (April through September) and cold (October through March) seasons.
  
  
  RESULTS
  The CVD mortality series exhibit strong seasonal trends, whereas the CVD hospitalization series show a strong day-of-week pattern. These outcome series were not correlated with each other but were individually associated with a number of PM(2.5) chemical components from regional and local sources, each with different seasonal patterns and lags. Coal-combustion-related components (e.g., selenium) were associated with CVD mortality in summer and CVD hospitalizations in winter, whereas elemental carbon and NO(2) showed associations with these outcomes in both seasons.
  
  
  CONCLUSIONS
  Local combustion sources, including traffic and residual oil burning, may play a year-round role in the associations between air pollution and CVD outcomes, but transported aerosols may explain the seasonal variation in associations shown by PM(2.5) mass.
authors.affiliation: New York University School of Medicine, Tuxedo, New York 10987, USA. ki7@nyu.edu
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ito
authors.forename: Robert
authors.initials: R
authors.lastname: Mathes
authors.forename: Zev
authors.initials: Z
authors.lastname: Ross
authors.forename: Arthur
authors.initials: A
authors.lastname: Nádas
authors.forename: George
authors.initials: G
authors.lastname: Thurston
authors.forename: Thomas
authors.initials: T
authors.lastname: Matte
mesh_terms: D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000032:analysis* / Q000633:toxicity; D000397:Air Pollution / Q000706:statistics & numerical data*; D002248:Carbon Monoxide / Q000032:analysis / Q000633:toxicity; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000401:mortality; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008875:Middle Aged; D009519:New York City / Q000453:epidemiology; D009585:Nitrogen Dioxide / Q000032:analysis / Q000633:toxicity; D010316:Particle Size; D052638:Particulate Matter / Q000032:analysis* / Q000633:toxicity; D013458:Sulfur Dioxide / Q000032:analysis
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D013458:Sulfur Dioxide; D002248:Carbon Monoxide; D009585:Nitrogen Dioxide