title: Syntheses of marchantins C, O and P as promising highly bioactive compounds.
abstract: Recently, remarkable microtubule inhibitor and anti-tumor activities of the bis(bibenzyl) marchantin C--isolated from liverworts like Marchantia polymorpha since 1983--were found. In this paper we describe the efficient total synthesis of this subtype of bis(bibenzylic) compounds with two biarylether connections. Two selectively methylated derivatives known as natural compounds marchantin O and P were synthesized for the first time by modification of the arene subunits and can now be considered as promising highly bioactive compounds.
authors.affiliation: Department of Chemistry, Saarland University, Saarbrücken, Germany. anspeich@mx.uni-saarland.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Speicher
authors.forename: Judith
authors.initials: J
authors.lastname: Holz
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hoffmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D001632:Bibenzyls / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D047008:Marchantia / Q000737:chemistry*; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010647:Phenyl Ethers / Q000138:chemical synthesis* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D007202:Indicators and Reagents; D010647:Phenyl Ethers; D010936:Plant Extracts; C459129:marchantin C; C558321:marchantin O; C558322:marchantin P