title: Fgfr3 regulates development of the caudal telencephalon.
abstract: The fibroblast growth factor receptor 3 (Fgfr3) is expressed in a rostral(low) to caudal(high) gradient in the developing cerebral cortex. Therefore, we hypothesized that Fgfr3 contributes to the correct morphology and connectivity of the caudal cortex. Overall, the forebrain structures appeared normal in Fgfr3(-/-) mice. However, cortical and hippocampal volumes were reduced by 26.7% and 16.3%, respectively. Hypoplasia was particularly evident in the caudo-ventral region of the telencephalon where proliferation was mildly decreased at embryonic day 18.5. Dysplasia of GABAergic neurons in the amygdala and piriform cortex was seen following GAD67 immunohistochemistry. Dye-tracing studies and diffusion magnetic resonance imaging and tractography detected a subtle thalamocortical tract deficit, and significant decreases in the stria terminalis and lateral arms of the anterior commissure. These results indicate the subtle role of Fgfr3 in formation of caudal regions of the telencephalon affecting some brain projections.
authors.affiliation: The University of Queensland, Queensland Brain Institute, Brisbane, Australia.
authors.forename: Randal X
authors.initials: RX
authors.lastname: Moldrich
authors.forename: Cecilia
authors.initials: C
authors.lastname: Mezzera
authors.forename: William M
authors.initials: WM
authors.lastname: Holmes
authors.forename: Sailaja
authors.initials: S
authors.lastname: Goda
authors.forename: Sam J
authors.initials: SJ
authors.lastname: Brookfield
authors.forename: Alastair J
authors.initials: AJ
authors.lastname: Rankin
authors.forename: Emily
authors.initials: E
authors.lastname: Barr
authors.forename: Nyoman
authors.initials: N
authors.lastname: Kurniawan
authors.forename: Deborah
authors.initials: D
authors.lastname: Dewar
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Richards
authors.forename: Guillermina
authors.initials: G
authors.lastname: López-Bendito
authors.forename: Tomoko
authors.initials: T
authors.lastname: Iwata
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D002540:Cerebral Cortex / Q000196:embryology / Q000378:metabolism; D015536:Down-Regulation; D047108:Embryonic Development / Q000235:genetics / Q000502:physiology; D006624:Hippocampus / Q000196:embryology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008954:Models, Biological; D009434:Neural Pathways / Q000378:metabolism / Q000502:physiology; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology; D009929:Organ Size / Q000235:genetics; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D013687:Telencephalon / Q000196:embryology* / Q000378:metabolism
chemical_list: C496366:Fgfr3 protein, mouse; D051498:Receptor, Fibroblast Growth Factor, Type 3