title: Tumor microenvironment and progression.
abstract: Tumor blood vessels are heterogeneous, of at least six distinct types, are induced primarily by vascular endothelial growth factor-A (VEGF-A), and provide a potentially useful therapeutic target. Breast cancer is characterized by changes in the microenvironment that result in altered tensional homeostasis. Also, breast cancers arise as the result of epigenetic as well as genetic changes. Tumor blood vessel pericytes result, in part, from bone marrow precursor cells, and VEGF is a negative regulator of glioblastoma tumor cell invasion.
authors.affiliation: Department of Pathology, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. hdvorak@bidmc.harvard.edu
authors.forename: Harold F
authors.initials: HF
authors.lastname: Dvorak
authors.forename: Valerie M
authors.initials: VM
authors.lastname: Weaver
authors.forename: Thea D
authors.initials: TD
authors.lastname: Tlsty
authors.forename: Gabriele
authors.initials: G
authors.lastname: Bergers
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000098:blood supply / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000503:physiopathology; D009369:Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D059016:Tumor Microenvironment / Q000187:drug effects / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A