title: Liver involvement with acute myeloid leukemia.
abstract: Liver involvement with acute myeloid leukemia (AML) is rarely reported. The majority of published cases suggest a cholestatic picture and obstructive jaundice at presentation. On the contrary, our patient presented with transaminitis without cholestasis. Elevated liver function tests persisted in our patient despite cholecystectomy; however, they normalized with chemotherapy administration, suggesting that AML was the causative effect of the hepatitis-like picture. Our review of the literature revealed that most reported cases of AML with liver involvement had short-lived remissions and an overall ominous prognosis. In our opinion, patients who have liver involvement with AML should be offered alternative investigational therapies with a low hepatic toxicity profile.
authors.affiliation: Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, Ill., USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Mathews
authors.forename: Timothy
authors.initials: T
authors.lastname: Laurie
authors.forename: Kenneth
authors.initials: K
authors.lastname: O'Riordan
authors.forename: Chadi
authors.initials: C
authors.lastname: Nabhan