title: Obesity and chronic kidney disease in patients with chronic heart failure: an insight from the China Heart Survey.
abstract: BACKGROUND
  Obesity and decreased kidney function have been shown to be prevalent in Western patients with heart failure; however, whether this phenomenon exists in Chinese patients with chronic heart failure (CHF) is not known.
  
  
  RESULTS
  One thousand and nine patients with CHF from the China Heart Survey were assessed. The prevalence of chronic kidney disease (CKD) was 34.2%, and there was a stepwise increase in the prevalence of CKD with New York Heart Association (NYHA) classes (P < 0.001). Moreover, patients with CKD had a significantly elevated risk for developing severe extent of CHF (OR = 1.69, 95% CI: 1.27-2.24, P < 0.001). The prevalence of obesity and central obesity was 35.7% and 62.5%, respectively. Notably, there was a downward trend in the prevalence of obesity with advanced NYHA classes (trend test, P = 0.003). Multivariate analysis further supported the finding that obesity, but not central obesity, was inversely associated with the extent of CHF (OR = 0.72, 95% CI: 0.55-0.94, P = 0.017).
  
  
  CONCLUSIONS
  Renal dysfunction is common in Chinese patients with CHF and is independently associated with advanced NYHA classes. Obesity was inversely associated with the extent of CHF, which further supports the notion that obesity confers improved prognosis in patients with heart failure.
authors.affiliation: Clinical Research Institute, School of Public Health, Fudan University, 130 Dong-An Rd., Shanghai 200032, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Shi
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Qingwu
authors.initials: Q
authors.lastname: Jiang
authors.forename: Dayi
authors.initials: D
authors.lastname: Hu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000453:epidemiology