title: Specificity of Drosophila cytonemes for distinct signaling pathways.
abstract: Cytonemes are types of filopodia in the Drosophila wing imaginal disc that are proposed to serve as conduits in which morphogen signaling proteins move between producing and target cells. We investigated the specificity of cytonemes that are made by target cells. Cells in wing discs made cytonemes that responded specifically to Decapentaplegic (Dpp) and cells in eye discs made cytonemes that responded specifically to Spitz (the Drosophila epidermal growth factor protein). Tracheal cells had at least two types: one made in response to Branchless (a Drosophila fibroblast growth factor protein, Bnl), to which they segregate the Bnl receptor, and another to which they segregate the Dpp receptor. We conclude that cells can make several types of cytonemes, each of which responds specifically to a signaling pathway by means of the selective presence of a particular signaling protein receptor that has been localized to that cytoneme.
authors.affiliation: Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.
authors.forename: Sougata
authors.initials: S
authors.lastname: Roy
authors.forename: Frank
authors.initials: F
authors.lastname: Hsiung
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Kornberg
mesh_terms: D000818:Animals; D054910:Compound Eye, Arthropod / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D004330:Drosophila / Q000166:cytology / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D018869:Heat-Shock Response; D053823:Hedgehog Proteins / Q000378:metabolism; D007814:Larva; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011554:Pseudopodia / Q000378:metabolism* / Q000648:ultrastructure; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D015398:Signal Transduction; D014132:Trachea / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D014921:Wings, Animal / Q000166:cytology / Q000254:growth & development / Q000648:ultrastructure
chemical_list: D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D008024:Ligands; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D011993:Recombinant Fusion Proteins; C102644:bnl protein, Drosophila; C064196:dpp protein, Drosophila; C076026:spi protein, Drosophila; C077245:hh protein, Drosophila; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; C090169:tkv protein, Drosophila; C102301:BTL protein, Drosophila; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases