title: Interaction of 5-HTTLPR genotype and unipolar major depression in the emergence of aggressive/hostile traits.
abstract: OBJECTIVE
  The 5-HTTLPR polymorphism has been associated both with depression and aggression/hostility. The multidirectional association between depression, aggression and the s allele may be important, since all these phenomena are related to suicidal behavior. Our aim was to investigate the association between 5-HTTLPR and aggressive/hostile traits in depressed patients and controls.
  
  
  METHODS
  137 depressive and 118 control women completed the Buss-Durkee Hostility Inventory and were genotyped for 5-HTTLPR. BDHI scores in the different groups were investigated by Generalized Linear Model Analysis. Association between dependent and independent variables in the model was tested by the likelihood ratio Chi-square statistic.
  
  
  RESULTS
  Diagnosis and genotype showed a significant association with several aggressive/hostile traits. Interaction of the two main effects was also significant in case of several subscales. Post hoc analyses indicated a significant association between BDHI subscales and s allele only in the depressed group.
  
  
  CONCLUSIONS
  Only women were studied and since gender differences are present both in aggressive behavior and putatively in the behavioral effects of 5-HTTLPR genotype, our findings pertain only to females.
  
  
  CONCLUSIONS
  Our results indicate a robust relationship between aggression/hostility and 5-HTTLPR genotype, but this association is more marked in the presence of depression. The presence of the s allele thus not only contributes to a higher risk of depression, but in depressives also leads to higher aggression/hostility. Our results have important implications for suicide research, since the s allele is associated with violent suicide, and this association may be mediated through the emergence of increased aggression/hostility in depressed patients carrying the s allele.
authors.affiliation: Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center, Semmelweis University, Budapest, Hungary. kendermagos@yahoo.com
authors.forename: Xenia
authors.initials: X
authors.lastname: Gonda
authors.forename: Konstantinos N
authors.initials: KN
authors.lastname: Fountoulakis
authors.forename: Gabor
authors.initials: G
authors.lastname: Csukly
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Bagdy
authors.forename: Dorottya
authors.initials: D
authors.lastname: Pap
authors.forename: Eszter
authors.initials: E
authors.lastname: Molnár
authors.forename: Andras
authors.initials: A
authors.lastname: Laszik
authors.forename: Judit
authors.initials: J
authors.lastname: Lazary
authors.forename: Andrea
authors.initials: A
authors.lastname: Sarosi
authors.forename: Gabor
authors.initials: G
authors.lastname: Faludi
authors.forename: Maria
authors.initials: M
authors.lastname: Sasvari-Szekely
authors.forename: Anna
authors.initials: A
authors.lastname: Szekely
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Rihmer
mesh_terms: D000328:Adult; D000374:Aggression; D000483:Alleles; D016022:Case-Control Studies; D003863:Depression / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics* / Q000523:psychology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006791:Hostility; D006801:Humans; D001523:Mental Disorders / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011569:Psychiatric Status Rating Scales; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D013405:Suicide
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins