title: Effects of long-term use of depo-medroxyprogesterone acetate on lipid metabolism in Nepalese women.
abstract: Various synthetic progestogens that are used as contraceptives have been reported to influence lipid and lipoprotein fractions differently. Depo-medroxyprogesterone acetate (DMPA), a synthetic progestogen, is used by Nepalese women as a contraceptive agent. Our study aims to determine the effects of long-term use of DMPA on lipid metabolism. We performed this study on 60 healthy Nepalese women who had been using DMPA for more than 2 yr and age- and weight-matched control subjects who were not using hormonal contraceptives. Fasting blood samples were collected from the subjects for the estimation of total cholesterol (TC) and triglyceride (TG) levels, and the levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were estimated using the Friedewald's equation. TC and LDL-C levels in DMPA users were significantly higher than those in non-users. Our study concluded that DMPA use induces lipid metabolism changes that can increase the risk of cardiovascular diseases.
authors.affiliation: Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal. binod3aug@gmail.com
authors.forename: Binod Kumar
authors.initials: BK
authors.lastname: Yadav
authors.forename: Rajesh Kumar
authors.initials: RK
authors.lastname: Gupta
authors.forename: Prajwal
authors.initials: P
authors.lastname: Gyawali
authors.forename: Rojeet
authors.initials: R
authors.lastname: Shrestha
authors.forename: Bibek
authors.initials: B
authors.lastname: Poudel
authors.forename: Manoj
authors.initials: M
authors.lastname: Sigdel
authors.forename: Bharat
authors.initials: B
authors.lastname: Jha
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000032:analysis; D008078:Cholesterol, LDL / Q000032:analysis; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D017258:Medroxyprogesterone Acetate / Q000009:adverse effects*; D009390:Nepal; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003271:Contraceptive Agents, Female; D014280:Triglycerides; D002784:Cholesterol; D017258:Medroxyprogesterone Acetate