title: [Experimental study on Qi deficiency and blood stasis induced by muti-factor stimulation in rats].
abstract: OBJECTIVE
  Animal model of Qi deficiency and blood stasis was established by muti-factor stimulation in rats.
  
  
  METHODS
  Healthy SD rats were chronically stimulated randomly by muti-factor methods (chronic sleep deprivation and feed with moderately high lipid and sugar food). Then the indices of hemorheology, plasma total lipids, vasoactive molecules, blood pressure (BP) and ventricular pressure (VP) were measured.
  
  
  RESULTS
  The results as well as the analysis of etiology and pathology suggested that model rats could objectively reflect the clinical characteristics of Qi deficiency and blood stasis syndrome. Blood viscosity at low level, plasma content of angiotensin II (Ang II) and endothelin (ET) significantly increased in model rats, while BP and VP significantly decreased (P < 0.05). On the other hand, Buyang Huanwu decoction could lower down the level of AngII in serum and blood viscosity at low level in rats induced by some stimulus, whereas BP and VP elevated significantly (P < 0.05).
  
  
  CONCLUSIONS
  Animal model of Qi deficiency and blood stasis induced by muti-factor stimulation including chronic sleep deprivation and feed with moderately high lipid and sugar food could facilitate further study on blood stasis syndrome and screening of Chinese herbal drugs in promoting blood circulation and removing blood stasis.
authors.affiliation: China Academy of Traditional Chinese Medicine, Xiyuan Hospital, Beijing 100091, China.
authors.forename: Jianxun
authors.initials: J
authors.lastname: Ren
authors.forename: Chengren
authors.initials: C
authors.lastname: Lin
authors.forename: Jianxun
authors.initials: J
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Wang
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage; D018056:Hemorheology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D019413:Qi; D011897:Random Allocation; D051381:Rats; D016710:Yin Deficiency / Q000097:blood* / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
chemical_list: D004365:Drugs, Chinese Herbal; D008055:Lipids