title: [Anakinra in refractory adult onset Still's disease].
abstract: BACKGROUND
  Adult onset Still's disease (AOSD) is a rare--but potentially dangerous and difficult to treat--generalized auto-inflammatory disease which shares some similarities with the systemic form of juvenile idiopathic arthritis (SoJIA or Still's disease).
  
  
  METHODS
  AOSD was diagnosed in 2 young adult women of 21 and 23 years old. The disease was found to be resistant to treatment in these patients. The patients were treated successively with NSAIDs, glucocorticoids, methotrexate and anti tumour necrosis factor(TNF)-α antagonists, with only partial effects or none at all. Treatment with the interleukin-1 receptor antagonist anakinra was subsequently started, which led to remission of AOSD.
  
  
  CONCLUSIONS
  These cases illustrate the clinical spectrum of AOSD and the possibility of an important addition to the therapeutic arsenal for treatment of refractory AOSD.
authors.affiliation: Atrium Medisch Centrum Parkstad, afd. Reumatologie, Heerlen, the Netherlands. wardvercoutere@yahoo.com
authors.forename: Ward
authors.initials: W
authors.lastname: Vercoutere
authors.forename: Mirian
authors.initials: M
authors.lastname: Starmans-Kool
authors.forename: Ralph M
authors.initials: RM
authors.lastname: Peeters
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018501:Antirheumatic Agents; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1