title: Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study.
abstract: OBJECTIVE
  To clarify the association of clinical and prognostic features with dermatomyositis (DM)-specific autoantibodies (Abs) in adult Japanese patients with DM.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Kanazawa University Graduate School of Medical Science Department of Dermatology and collaborating medical centers. Patients A total of 376 consecutive adult Japanese patients with DM who visited our hospital or collaborating medical centers between 2003 and 2008.
  
  
  METHODS
  Clinical and laboratory characteristics of adult Japanese patients with DM and DM-specific Abs that include Abs against Mi-2, 155/140, and CADM-140.
  
  
  RESULTS
  In patients with DM, anti-Mi-2, anti-155/140, and anti-CADM-140 were detected in 9 (2%), 25 (7%), and 43 (11%), respectively. These DM-specific Abs were mutually exclusive and were detected in none of 34 patients with polymyositis, 326 with systemic sclerosis, and 97 with systemic lupus erythematosus. Anti-Mi-2 was associated with classical DM without interstitial lung disease or malignancy, whereas anti-155/140 was associated with malignancy. Patients with anti-CADM-140 frequently had clinically amyopathic DM and rapidly progressive interstitial lung disease. Cumulative survival rates were more favorable in patients with anti-Mi-2 compared with those with anti-155/140 or anti-CADM-140 (P < .01 for both comparisons). Nearly all deaths occurred within 1 year after diagnosis in patients with anti-CADM-140. Conclusion Dermatomyositis-specific Abs define clinically distinct subsets and are useful for predicting clinical outcomes in patients with DM.
authors.affiliation: Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Hamaguchi
authors.forename: Masataka
authors.initials: M
authors.lastname: Kuwana
authors.forename: Kana
authors.initials: K
authors.lastname: Hoshino
authors.forename: Minoru
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kaji
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsushita
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Komura
authors.forename: Motonobu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Masanari
authors.initials: M
authors.lastname: Kodera
authors.forename: Norihiro
authors.initials: N
authors.lastname: Suga
authors.forename: Akira
authors.initials: A
authors.lastname: Higashi
authors.forename: Koji
authors.initials: K
authors.lastname: Ogusu
authors.forename: Kiyohiro
authors.initials: K
authors.lastname: Tsutsui
authors.forename: Akira
authors.initials: A
authors.lastname: Furusaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanabe
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Sasaoka
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Muro
authors.forename: Mika
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Naoko
authors.initials: N
authors.lastname: Ishiguro
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ayano
authors.forename: Eiji
authors.initials: E
authors.lastname: Muroi
authors.forename: Keita
authors.initials: K
authors.lastname: Fujikawa
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Umeda
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kawase
authors.forename: Eriko
authors.initials: E
authors.lastname: Mabuchi
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Sodemoto
authors.forename: Mariko
authors.initials: M
authors.lastname: Seishima
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Yamada
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Takehara
authors.forename: Manabu
authors.initials: M
authors.lastname: Fujimoto
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001323:Autoantibodies / Q000097:blood / Q000187:drug effects / Q000276:immunology*; D003430:Cross-Sectional Studies; D003882:Dermatomyositis / Q000188:drug therapy / Q000276:immunology* / Q000401:mortality; D005260:Female; D005938:Glucocorticoids / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000276:immunology / Q000401:mortality; D008297:Male; D008775:Methylprednisolone / Q000276:immunology / Q000627:therapeutic use; D008875:Middle Aged; D011239:Prednisolone / Q000276:immunology / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D005938:Glucocorticoids; D011239:Prednisolone; D008775:Methylprednisolone