title: Synthesis of rare sugars with L-fuculose-1-phosphate aldolase (FucA) from Thermus thermophilus HB8.
abstract: We report herein a one-pot four-enzyme approach for the synthesis of the rare sugars d-psicose, d-sorbose, l-tagatose, and l-fructose with aldolase FucA from a thermophilic source (Thermus thermophilus HB8). Importantly, the cheap starting material DL-GP (DL-glycerol 3-phosphate), was used to significantly reduce the synthetic cost.
authors.affiliation: National Glycoengineering Research Center and the State Key Laboratory of Microbial Technology, Shandong University, Jinan, Shandong 250100, China.
authors.forename: Zijie
authors.initials: Z
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Cai
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Qi
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Styslinger
authors.forename: Guohui
authors.initials: G
authors.lastname: Zhao
authors.forename: Peng George
authors.initials: PG
authors.lastname: Wang
mesh_terms: D000446:Aldehyde-Lyases / Q000378:metabolism*; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D016963:Thermus thermophilus / Q000201:enzymology*
chemical_list: D002241:Carbohydrates; D000446:Aldehyde-Lyases; C036027:L-fuculosephosphate aldolase