title: Inhibition of ganglioside biosynthesis as a novel therapeutic approach in insulin resistance.
abstract: A new concept "Life style-related diseases, such as type 2 diabetes, are a membrane microdomain disorder caused by aberrant expression of gangliosides" has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in microdomains microdomains and propose the new therapeutic strategy "membrane microdomain ortho-signaling therapy".
authors.affiliation: Division of Glycopathology and CREST, Japan. jin@tohoku-pharm.ac.jp
authors.forename: Jin-Ichi
authors.initials: J
authors.lastname: Inokuchi
mesh_terms: D000818:Animals; D015415:Biomarkers; D021941:Caveolae / Q000502:physiology; D003920:Diabetes Mellitus / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D005679:G(M3) Ganglioside / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology; D005732:Gangliosides / Q000037:antagonists & inhibitors* / Q000096:biosynthesis* / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007333:Insulin Resistance / Q000502:physiology*; D024821:Metabolic Syndrome / Q000097:blood / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D015415:Biomarkers; D005679:G(M3) Ganglioside; D005732:Gangliosides; D007004:Hypoglycemic Agents