title: O6 -methylguanine DNA methyltransferase gene promoter methylation in high-grade gliomas: a review of current status.
abstract: Assessment of promoter methylation of the O 6 -methylguanine DNA methyltransferase (MGMT) gene has recently gained importance in molecular profiling of high-grade gliomas. It has emerged not only as an important prognostic marker but also as a predictive marker for response to temozolomide in patients with newly diagnosed glioblastoma. Further, recent studies indicate that MGMT promoter methylation has strong prognostic relevance even in anaplastic (grade III) gliomas, irrespective of therapy (chemotherapy or radiotherapy). This article provides an overview of its use as a predictive and prognostic biomarker, as well as the methods employed for its assessment and use in therapeutic decision making.
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Vaishali
authors.initials: V
authors.lastname: Suri
authors.forename: Prerana
authors.initials: P
authors.lastname: Jha
authors.forename: Mehar Chand
authors.initials: MC
authors.lastname: Sharma
authors.forename: Chitra
authors.initials: C
authors.lastname: Sarkar
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D019175:DNA Methylation; D005910:Glioma / Q000235:genetics*; D006801:Humans; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic
chemical_list: D019853:O(6)-Methylguanine-DNA Methyltransferase