title: Indocyanine green angiography findings in acute retinal necrosis syndrome.
abstract: BACKGROUND
  Acute retinal necrosis syndrome is clinically defined by the presence of peripheral necrotizing retinitis associated with severe occlusive vasculitis caused primarily by herpes simplex virus and varicella zoster virus. Previously considered as an exclusively retinal pathology, choroidal involvement, as demonstrated by indocyanine green angiography, has not been extensively studied.
  
  
  METHODS
  Indocyanine green angiography was performed in 4 patients with ARN. Observed angiographic patterns included: 1. a characteristic triangular area of hypo-perfusion, 2. hypofluorescent lobular patches and areas of fuzzy choroidal vascular hyperfluorescence, and 3. isolated hypofluorescent lobular patches of the contralateral eye.
  
  
  RESULTS
  Marked choroidal hypo-perfusion on indocyanine green angiography was associated with extensive retinal ischemia. Treatment included a combination of antiviral agents and corticosteroids complemented by prophylactic acetylsalicylate.
  
  
  CONCLUSIONS
  Indocyanine green angiography may provide important information regarding choroidal vascular involvement in ARN. It may also permit the timely identification of sub-clinical contralateral eye involvement.
authors.affiliation: Jules Gonin Eye Hospital, University of Lausanne, Department of Ophthalmology, Lausanne, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Bissig
authors.forename: K
authors.initials: K
authors.lastname: Balaskas
authors.forename: J D
authors.initials: JD
authors.lastname: Vaudaux
authors.forename: Y
authors.initials: Y
authors.lastname: Guex-Crosier
mesh_terms: D000328:Adult; D000792:Angiography / Q000379:methods*; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D015882:Retinal Necrosis Syndrome, Acute / Q000473:pathology*; D012680:Sensitivity and Specificity
chemical_list: D007208:Indocyanine Green