title: Quinoxaline 1,4-di-N-oxide and the potential for treating tuberculosis.
abstract: New drugs active against drug-resistant tuberculosis are urgently needed to extend the range of TB treatment options to cover drug resistant infections. Quinoxaline derivatives show very interesting biological properties (antibacterial, antiviral, anticancer, antifungal, antihelmintic, insecticidal) and evaluation of their medicinal chemistry is still in progress. In this review we report the properties and the recent developments of quinoxaline 1,4-di-N-oxide derivatives as potential anti-tuberculosis agents. Specific agents are reviewed that have excellent antitubercular drug properties, are active on drug resistant strains and non-replicating mycobacteria. The properties of select analogs that have in vivo activity in the low dose aerosol infection model in mice will be reviewed.
authors.affiliation: Unidad de Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada, University of Navarra, C/ Irunlarrea s/n, Pamplona, Spain. estherviccem@gmail.com
authors.forename: Esther
authors.initials: E
authors.lastname: Vicente
authors.forename: Raquel
authors.initials: R
authors.lastname: Villar
authors.forename: Silvia
authors.initials: S
authors.lastname: Pérez-Silanes
authors.forename: Ignacio
authors.initials: I
authors.lastname: Aldana
authors.forename: Robert C
authors.initials: RC
authors.lastname: Goldman
authors.forename: Antonio
authors.initials: A
authors.lastname: Mong
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D051379:Mice; D011810:Quinoxalines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D011810:Quinoxalines; C003282:quindoxin