title: Association of hypertriglyceridemia with insulin resistance in healthy Miniature Schnauzers.
abstract: OBJECTIVE
  To determine whether hypertriglyceridemia in Miniature Schnauzers is associated with insulin resistance.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  28 Miniature Schnauzers with hypertriglyceridemia and 31 Miniature Schnauzers for which serum triglyceride concentrations were within the reference range (control dogs).
  
  
  METHODS
  All dogs had no history of chronic disease, were free of clinical signs for at least 3 months prior to blood collection, and were not receiving any medications known to affect lipid metabolism or serum insulin concentration. Food was withheld from each dog for ≥ 12 hours; a 5- to 10-mL blood sample was collected and allowed to clot to obtain serum. Serum insulin and glucose concentrations were measured, and the homeostasis model assessment (HOMA) score was calculated (ie, [basal serum insulin concentration {mU/L} × basal serum glucose concentration {mmol/L}]/22.5).
  
  
  RESULTS
  Median serum insulin concentration was significantly higher in hypertriglyceridemic Miniature Schnauzers (21.3 mU/L) than it was in control dogs (12.5 mU/L). The percentage of dogs with high serum insulin concentrations was significantly greater in the hypertriglyceridemic group (28.6%) than it was in the control group (6.5%; odds ratio, 5.8; 95% confidence interval, 1.1 to 30.2). Median HOMA score for hypertriglyceridemic Miniature Schnauzers (4.9) was significantly higher than that for control dogs (2.8).
  
  
  CONCLUSIONS
  Results indicated that hypertriglyceridemia in Miniature Schnauzers is often associated with insulin resistance. Further studies are needed to determine the prevalence and clinical importance of insulin resistance in hypertriglyceridemic Miniature Schnauzers.
authors.affiliation: Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. pxenoulis@gmail.com
authors.forename: Panagiotis G
authors.initials: PG
authors.lastname: Xenoulis
authors.forename: Melinda D
authors.initials: MD
authors.lastname: Levinski
authors.forename: Jan S
authors.initials: JS
authors.lastname: Suchodolski
authors.forename: Jörg M
authors.initials: JM
authors.lastname: Steiner
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000209:etiology*; D004285:Dogs; D005260:Female; D015228:Hypertriglyceridemia / Q000097:blood / Q000662:veterinary*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male