title: Advances in methods for therapeutic peptide discovery, design and development.
abstract: Drug discovery and development are intense, lengthy and interdisciplinary processes. Traditionally, drugs were discovered by synthesizing compounds in time-consuming multi-step experimental investigations followed by in vitro and in vivo biological screening. Promising candidates were then further studied for their pharmacokinetic properties, metabolism and potential toxicity. Today, the process of drug discovery has been revolutionized due to the advances in genomics, proteomics, and bioinformatics. Efficient technologies such as combinatorial chemistry, high throughput screening (HTS), virtual screening, de novo design and structure-based drug design contribute greatly to drug discovery. Peptides are emerging as a novel class of drugs for cancer therapy, and many efforts have been made to develop peptide-based pharmacologically active compounds. This paper presents a review of current advances and novel approaches in experimental and computational drug discovery and design. We also present a novel bioactive peptide analogue, designed using the Resonant Recognition Model (RRM), and discuss its potential use for cancer therapeutics.
authors.affiliation: School of Electrical and Computer Engineering, Health Innovations Research Institute, RMIT University, Melbourne 3001 Australia. elena.pirogova@rmit.edu.au
authors.forename: E
authors.initials: E
authors.lastname: Pirogova
authors.forename: T
authors.initials: T
authors.lastname: Istivan
authors.forename: E
authors.initials: E
authors.lastname: Gan
authors.forename: I
authors.initials: I
authors.lastname: Cosic
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015195:Drug Design; D055808:Drug Discovery; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D018613:Microscopy, Confocal; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000188:drug therapy; D010455:Peptides / Q000627:therapeutic use*
chemical_list: D010455:Peptides; D007770:L-Lactate Dehydrogenase