title: [An association study of COMT gene polymorphisms with schizophrenia].
abstract: OBJECTIVE
  To investigate the association between 8 polymorphisms in the catechol-O-methyl transferase gene (COMT) and schizophrenia in Yuedong-Chaoshan region of China.
  
  
  METHODS
  Eight single nucleotide polymorphism (SNPs), namely rs4680, rs4818, rs165599, rs737865, rs2075507, rs6267, rs6269 and rs4633, in the COMT gene were genotyped in 279 schizophrenia patients and 100 healthy controls.
  
  
  RESULTS
  There was no significant difference between any single SNP and schizophrenia. However, association might exist between haplotypes (G)-G-A-A [(rs4680)-rs165599-rs2075507-rs6269] and A-A-C-(G) [rs2075507-rs6269-rs4633-(rs6267)] and schizophrenia.
  
  
  CONCLUSIONS
  In the population of Yuedong region of China, the eight SNPs (rs4680, rs4818, rs165599, rs737865, rs2075507, rs6267, rs6269 and rs4633) in the COMT gene are unlikely to play a major role in the susceptibility to schizophrenia. There might be protective haplotypes in the COMT gene against schizophrenia.
authors.affiliation: Guangdong Academy of Medical Science, Guangdong Provincial People's Hospital, Guangdong Provincial Mental Health Institute, Guangzhou, Guangdong, 510120 P. R. China.
authors.forename: Fan-zhi
authors.initials: FZ
authors.lastname: KONG
authors.forename: Zhi-zhen
authors.initials: ZZ
authors.lastname: PENG
authors.forename: Ting-yun
authors.initials: TY
authors.lastname: JIANG
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: HONG
mesh_terms: D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*; D055815:Young Adult
chemical_list: D002394:Catechol O-Methyltransferase