title: Infection of mice with Francisella as an immunological model.
abstract: This unit describes the utility of various mouse models of infection for studying pathogenesis and adaptive immune responses to the facultative intracellular bacteria pathogen Francisella tularensis. By judicious use of different combinations of mouse and bacterial strains, as well as different routes of infection, murine tularemia models may be used to explore a complete picture of F. tularensis infection and immunity. Moreover, studies using Francisella, particularly the Live Vaccine Strain (LVS), serve as a convenient and tractable model system that appears to be representative of mammalian host responses to intracellular pathogens in general.
authors.affiliation: National Research Council of Canada, Institute for Biological Sciences, Ottawa, Ontario, Canada.
authors.forename: J Wayne
authors.initials: JW
authors.lastname: Conlan
authors.forename: Wangxue
authors.initials: W
authors.lastname: Chen
authors.forename: Catharine M
authors.initials: CM
authors.lastname: Bosio
authors.forename: Siobhán C
authors.initials: SC
authors.lastname: Cowley
authors.forename: Karen L
authors.initials: KL
authors.lastname: Elkins
mesh_terms: D000825:Animal Structures / Q000276:immunology / Q000382:microbiology; D000818:Animals; D016470:Bacteremia / Q000276:immunology; D001431:Bacteriological Techniques / Q000379:methods; D004195:Disease Models, Animal; D054644:Ear Auricle / Q000276:immunology / Q000382:microbiology; D005604:Francisella tularensis / Q000166:cytology / Q000276:immunology / Q000472:pathogenicity; D041981:Gastrointestinal Tract / Q000276:immunology / Q000382:microbiology; D007158:Immunologic Techniques; D051379:Mice; D008815:Mice, Inbred Strains; D018482:Muscle, Skeletal / Q000276:immunology / Q000382:microbiology; D010529:Peritoneal Cavity / Q000382:microbiology; D012141:Respiratory Tract Infections / Q000276:immunology / Q000382:microbiology; D017192:Skin Diseases, Bacterial / Q000276:immunology / Q000382:microbiology; D014406:Tularemia / Q000209:etiology / Q000276:immunology* / Q000382:microbiology*