title: No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis.
abstract: Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.
authors.affiliation: Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan. hashimor@psy.med.osaka-u.ac.jp
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ohi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Fukumoto
authors.forename: Hidenaga
authors.initials: H
authors.lastname: Yamamori
authors.forename: Kouzin
authors.initials: K
authors.lastname: Kamino
authors.forename: Takashi
authors.initials: T
authors.lastname: Morihara
authors.forename: Masao
authors.initials: M
authors.lastname: Iwase
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kazui
authors.forename: Shusuke
authors.initials: S
authors.lastname: Numata
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Ueno
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohmori
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D001324:Autoantigens / Q000235:genetics*; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D001324:Autoantigens; D018797:Cell Cycle Proteins; C086074:PCM1 protein, human