title: Epigenetic mechanisms in Alzheimer's disease.
abstract: Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-causing changes in phenotype by altering transcriptional activity in multiple genes spanning multiple biologic pathways. Although previous epigenetic research has focused primarily on dividing cells, particularly in cancer, recent studies have shown rapid, dynamic, and persistent epigenetic modifications in neurons that have significant neuroendocrine, neurophysiologic, and neurodegenerative consequences. Here, we provide a review of the major mechanisms for epigenetic modification and how they are reportedly altered in aging and Alzheimer's disease (AD). Because of their reach across the genome, epigenetic mechanisms may provide a unique integrative framework for the pathologic diversity and complexity of AD.
authors.affiliation: Banner Sun Health Research Institute, Sun City, AZ 85372, USA.
authors.forename: Diego
authors.initials: D
authors.lastname: Mastroeni
authors.forename: Andrew
authors.initials: A
authors.lastname: Grover
authors.forename: Elaine
authors.initials: E
authors.lastname: Delvaux
authors.forename: Charisse
authors.initials: C
authors.lastname: Whiteside
authors.forename: Paul D
authors.initials: PD
authors.lastname: Coleman
authors.forename: Joseph
authors.initials: J
authors.lastname: Rogers
mesh_terms: D000375:Aging / Q000235:genetics* / Q000502:physiology; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D044127:Epigenesis, Genetic / Q000502:physiology*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006657:Histones / Q000235:genetics / Q000502:physiology; D006801:Humans
chemical_list: D006657:Histones