title: Temporal lobe epilepsy and anti glutamic acid decarboxylase autoimmunity.
abstract: Epilepsy is one of the most impactful diseases on social life. A significant number of epileptic syndromes have been linked to immunological alterations. Elevated levels of antibodies against glutamic acid decarboxylase have been recently found in a significant percentage of patients with temporal lobe epilepsy, the most common epilepsy type. The clinical and pathogenetic relationship of this association is discussed. This link may have important therapeutic implications and merits additional clinical and laboratory research.
authors.affiliation: Department of Neurological Sciences, Epilepsy Center, Federico II University, Via Pansini 5, Naples, Italy. luca.errichiello@gmail.com
authors.forename: Luca
authors.initials: L
authors.lastname: Errichiello
authors.forename: Salvatore
authors.initials: S
authors.lastname: Striano
authors.forename: Federico
authors.initials: F
authors.lastname: Zara
authors.forename: Pasquale
authors.initials: P
authors.lastname: Striano
mesh_terms: D000818:Animals; D000906:Antibodies / Q000502:physiology; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D015551:Autoimmunity / Q000502:physiology*; D004827:Epilepsy / Q000276:immunology / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000276:immunology*; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D000906:Antibodies; D007166:Immunosuppressive Agents; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase