title: Leiomyolipoma of the orbit.
abstract: Orbital leiomyolipoma is a rare benign tumor characterized by a mixture of mature smooth muscle cells and adipocytes. The authors present a case which, to the best of their knowledge, is the second case of leiomyolipoma of the orbit reported in the ophthalmic literature. A 65-year-old patient presented with a painful and swollen left eye, the symptoms having been present for 1 week. Imaging (CT, MRI follow up) confirmed the presence of a nearly 2-cm lesion medial to the lacrimal gland. A biopsy was planned, and 3 specimens were taken for histologic examination. Histology showed diffusely intermingling smooth muscle cells and mature adipocytes; immunohistochemistry demonstrated positive staining for smooth muscle actin and negativity for HMB45, MART-1, and Cytokeratin AE1/3. Although it is very rare, ophthalmologists should consider leiomyolipoma in the differential diagnosis of orbital tumors. The long-term prognosis for patients affected by this benign tumor is good.
authors.affiliation: Department of Ophthalmology, University of Würzburg, Würzburg, Germany. maria.borrelli@gmail.com
authors.forename: Maria
authors.initials: M
authors.lastname: Borrelli
authors.forename: Diana
authors.initials: D
authors.lastname: Buhlbuck
authors.forename: Annette
authors.initials: A
authors.lastname: Strehl
authors.forename: Andreas
authors.initials: A
authors.lastname: Rosenwald
authors.forename: Laszlo
authors.initials: L
authors.lastname: Solymosi
authors.forename: Thomas
authors.initials: T
authors.lastname: Günthner-Lengsfeld
authors.forename: Gerd
authors.initials: G
authors.lastname: Geerling
mesh_terms: D000368:Aged; D003607:Dacryocystitis / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis*; D008067:Lipoma / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D009918:Orbital Neoplasms / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed