title: Lack of association between synapsin II (SYN2) gene polymorphism and susceptibility epilepsy: a case-control study and meta-analysis.
abstract: OBJECTIVE
  The SYN2 rs3773364 A>G polymorphism has been proposed to be involved in susceptibility to epilepsy, but research results have been inconclusive. The aim of this study was to investigate the association between the SYN2 rs3773364 A>G polymorphism and susceptibility against epilepsy in a case-control study and a meta-analysis.
  
  
  METHODS
  The SYN2 rs3773364 A>G polymorphism was successfully genotyped in 1182 samples (618 epilepsy patients) of Chinese, Indian, and Malay ethnicities. Meta-analysis of the related studies, including this case-control study, was performed under alternative genetic models.
  
  
  RESULTS
  Data from the case-control study indicated no allelic and genotypic association of this locus with susceptibility to epilepsy in the tri-ethnic Malaysian population. Similar finding was obtained by stratified analysis by epilepsy syndrome for idiopathic epilepsy. These results were verified by meta-analysis of the related pooled data.
  
  
  CONCLUSIONS
  Our study indicated that SYN2 rs3773364 A>G polymorphism is not a risk factor for susceptibility to epilepsy.
authors.affiliation: Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. batoolsadat@yahoo.com
authors.forename: Batoul Sadat
authors.initials: BS
authors.lastname: Haerian
authors.forename: Kheng Seang
authors.initials: KS
authors.lastname: Lim
authors.forename: Hui Jan
authors.initials: HJ
authors.lastname: Tan
authors.forename: Chee Piau
authors.initials: CP
authors.lastname: Wong
authors.forename: Sau Wei
authors.initials: SW
authors.lastname: Wong
authors.forename: Chong Tin
authors.initials: CT
authors.lastname: Tan
authors.forename: Azman Ali
authors.initials: AA
authors.lastname: Raymond
authors.forename: Zahurin
authors.initials: Z
authors.lastname: Mohamed
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D004827:Epilepsy / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008296:Malaysia / Q000208:ethnology; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D016704:Synapsins / Q000235:genetics*; D044465:White People / Q000208:ethnology / Q000235:genetics
chemical_list: D016704:Synapsins