title: Heterogeneous cardiac proteasomes: mandated by diverse substrates?
abstract: Proteasome biology has taken central stage in cardiac physiology and pathophysiology. The molecular heterogeneity of proteasome subpopulations supports the specificity of proteasome function to degrade diverse substrate repertoires. Unveiling the dynamics of proteasome function should inspire new therapeutic strategies for combating cardiac disease.
authors.affiliation: Departments of Physiology and Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Scruggs
authors.forename: Peipei
authors.initials: P
authors.lastname: Ping
authors.forename: Chenggong
authors.initials: C
authors.lastname: Zong
mesh_terms: D000818:Animals; D006321:Heart / Q000502:physiology*; D006801:Humans; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D013379:Substrate Specificity
chemical_list: D046988:Proteasome Endopeptidase Complex