title: Biodegradable poly(ethylene carbonate) nanoparticles as a promising drug delivery system with "stealth" potential.
abstract: The goal of this study was to investigate the suitability of poly(ethylene carbonate) (PEC) nanoparticles as a novel drug delivery system, fulfilling the requirements for a long circulation time. Particles were obtained with a narrow size distribution and nearly neutral zeta potential. Adsorption studies with human plasma proteins revealed that PEC nanoparticles bind much less proteins in comparison to polystyrene (PS) nanoparticles. Cell experiments with fluorescently labeled PEC showed no uptake of the nanoparticles by macrophages. These novel PEC nanospheres with their unique surface properties are a promising candidate for long circulating drug delivery systems in vivo.
authors.affiliation: Department of Pharmaceutics and Biopharmacy, Philipps-Universität, Ketzerbach 63, D-35037 Marburg, Germany.
authors.forename: Nadja
authors.initials: N
authors.lastname: Bege
authors.forename: Thomas
authors.initials: T
authors.lastname: Renette
authors.forename: Mirko
authors.initials: M
authors.lastname: Jansch
authors.forename: Regina
authors.initials: R
authors.lastname: Reul
authors.forename: Olivia
authors.initials: O
authors.lastname: Merkel
authors.forename: Holger
authors.initials: H
authors.lastname: Petersen
authors.forename: Catherine
authors.initials: C
authors.lastname: Curdy
authors.forename: Rainer H
authors.initials: RH
authors.lastname: Müller
authors.forename: Thomas
authors.initials: T
authors.lastname: Kissel
mesh_terms: D000327:Adsorption; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D051379:Mice; D054118:Nanospheres / Q000737:chemistry*; D010316:Particle Size; D011095:Polyethylenes / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D013499:Surface Properties
chemical_list: D001798:Blood Proteins; D004337:Drug Carriers; D005456:Fluorescent Dyes; D011095:Polyethylenes; C039212:polyethylene carbonate