title: Hearing Evaluation in Patients with Exfoliative and Primary Open-Angle Glaucoma.
abstract: OBJECTIVE
  The aim of this prospective study was to audiologically evaluate consecutive glaucoma patients with or without exfoliation.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Glaucoma Unit and Audiology Department at a university hospital.
  
  
  METHODS
  Consecutive subjects with exfoliative glaucoma (XFG) or primary open-angle glaucoma (POAG) aged between 50 and 70 years were enrolled. Auditory thresholds at 0.5, 1.0, 2.0, 4.0, and 8.0 Hz were measured bilaterally. Cochlear activity was assessed by recording distortion product otoacoustic emissions (DPOEs). Functional changes in the retrocochlear auditory pathway were evaluated by auditory brainstem responses (ABRs).
  
  
  RESULTS
  One hundred and ten patients with XFG and 85 patients with POAG who presented in a glaucoma clinic were investigated. The mean age of study patients was 66.2 ± 5.6 years; range, 50-70 years). The odds of pathologic ABR central transmission time (interpeak latencies I-III, III-V, and I-V and waves I, III, and V) were 4.34 times higher in patients with XFG than in patients with POAG (95% confidence interval [CI], 2.22-8.49; P < .001). This significant association remained after adjusting for sex and age (odds ratio [OR] 4.12; 95% CI, 2.07-8.22; P < .001). Furthermore, the odds of ABR remained significantly higher in patients with XFG than in patients with POAG (OR 4.36; 95% CI, 2.10-9.06; P < .001) after controlling for systemic diseases (arterial hypertension, coronary heart disease, high cholesterol, and stroke).
  
  
  CONCLUSIONS
  In the first study to compare XFG and POAG monitoring of the peripheral and central auditory pathway, it has been documented that XFG patients show a greater prevalence of retrocochlear pathology.
authors.affiliation: 1st Academic ENT Department, AHEPA Hospital, Thessaloniki, Greece. vanasoc@hotmail.com
authors.forename: Vassiliki P
authors.initials: VP
authors.lastname: Paliobei
authors.forename: Georgios K
authors.initials: GK
authors.lastname: Psillas
authors.forename: Dimitrios G
authors.initials: DG
authors.lastname: Mikropoulos
authors.forename: Anna-Bettina
authors.initials: AB
authors.lastname: Haidich
authors.forename: Jannis
authors.initials: J
authors.lastname: Constantinidis
authors.forename: Anastasios G P
authors.initials: AG
authors.lastname: Konstas
mesh_terms: D000368:Aged; D001301:Audiometry, Pure-Tone; D001306:Auditory Pathways / Q000503:physiopathology; D001309:Auditory Threshold / Q000502:physiology; D001933:Brain Stem / Q000503:physiopathology; D015897:Comorbidity; D003299:Cooperative Behavior; D003430:Cross-Sectional Studies; D016057:Evoked Potentials, Auditory, Brain Stem; D017889:Exfoliation Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D033183:Interdisciplinary Communication; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous; D010348:Patient Care Team; D011446:Prospective Studies; D012181:Retrocochlear Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology