title: Cancer therapy based on oncogene addiction.
abstract: Tumor cells contain multiple mutations, yet they often depend on continued expressed of a single oncoprotein for survival. Targeting these proteins has led to dramatic responses. Unfortunately, patients usually progress, through drug resistance or adaptive resistance through reprogramming of signaling networks. The Ras-MAPK pathway provides examples of these successes and failures, and has revealed unexpected degrees of oncogene addiction and signaling complexity that are likely to be useful lessons for the future of targeted therapy.
authors.affiliation: UCSF Helen Diller Family Comprehensive Cancer Center, University of California-San Francisco, San Francisco, California 94158-9001, USA. mccormick@cc.ucsf.edu
authors.forename: Frank
authors.initials: F
authors.lastname: McCormick
mesh_terms: D019008:Drug Resistance, Neoplasm; D006801:Humans; D020930:MAP Kinase Kinase Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D020935:MAP Kinase Signaling System / Q000187:drug effects*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D015513:Oncogene Proteins / Q000037:antagonists & inhibitors*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D048490:raf Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D015513:Oncogene Proteins; D047428:Protein Kinase Inhibitors; D048490:raf Kinases; D020930:MAP Kinase Kinase Kinases; D018631:ras Proteins