title: Use of granulocyte colony-stimulating factor for neutropenia after orthotopic liver transplantation: report of two cases.
abstract: Early postoperative infections are one of the major causes of morbidity and mortality following orthotopic liver transplantation. The severity of these infections may be increased in patients with neutropenia. There are no guidelines on the use of granulocyte colony-stimulating factor (G-CSF) for the treatment of neutropenia in posttransplant liver recipients. However, it has been recommended by several authors. We have herein presented two patients who were treated effectively with G-CSF. Both patients developed severe neutropenia (<500/mm(3)) on the third postoperative day, and received intravenous G-CSF administration for 3 days. The neutrophil counts gradually increased and additional infusions were not needed. The immunosuppressive and prophylactic treatments were not altered. G-CSF administration was used effectively for 3 days in our two patients. No evidence of infectious or acute rejection episode was encountered during or following G-CSF treatment.
authors.affiliation: Department of Gastrointestinal Surgery, Kartal Kosuyolu Yuksek Ihtisas Teaching and Research Hospital.
authors.forename: A E
authors.initials: AE
authors.lastname: Atici
authors.forename: E B
authors.initials: EB
authors.lastname: Bostanci
authors.forename: I
authors.initials: I
authors.lastname: Ozer
authors.forename: M
authors.initials: M
authors.lastname: Ulas
authors.forename: M
authors.initials: M
authors.lastname: Akdogan
authors.forename: M
authors.initials: M
authors.lastname: Akoglu
mesh_terms: D000328:Adult; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor