title: [Pathological findings after radical prostatectomy in men eligible for active surveillance (French trial SURACAP): is the misclassification rate acceptable?].
abstract: OBJECTIVE
  To analyze pathological data of the radical prostatectomy specimen in patients operated for clinically-localized prostate cancer and who meet strict criteria for active surveillance necessary to be included in the French trial SURACAP.
  
  
  METHODS
  The data of patients who underwent a radical prostatectomy at our institution between 1998 and 2010 were reviewed. We only included the patients that met the usual criteria for active surveillance: clinical stage T1-2a tumor, PSA ≤ 10 ng/mL, biopsy Gleason sum inferior or equal to 6 with no pattern of grade 4 or 5, cancer involvement inferior or equal to two biopsy cores, inferior to 3 mm of malignant tissue in each positive biopsy core. From them, only those who were diagnosed from a second line biopsies cores were included for further analysis.
  
  
  RESULTS
  Overall, 48 patient who met the "SURACAP" criteria had a laparoscopic radical prostatectomy at out institution. Mean age was 65.4 years. The mean preoperative PSA was 6.1 ng/mL. Clinical stage of the tumor was T1c in 95% of patients and T2a in 5%. Biopsy Gleason score was 6 (3+3) in 100%. Pathological analysis of the surgical specimen showed that 19% of patients had a seminal vesicle invasion or an extracapsular extension. The Gleason score of the pathological specimen was 6 (3+3) in 57% of patients, 7 (3+4) in 38% and 8 (4+4) in 5% of patients. The Gleason score upgrading was 43% of patients.
  
  
  CONCLUSIONS
  In our experience, 19% of patients who meet the criteria for active surveillance show an extracapsular extension or a seminal vesicle invasion on pathological analysis. Active surveillance is still under evaluation.
authors.affiliation: Service d'urologie, Inserm Unit 955 EQ7, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
authors.forename: E
authors.initials: E
authors.lastname: Xylinas
authors.forename: X
authors.initials: X
authors.lastname: Durand
authors.forename: A
authors.initials: A
authors.lastname: Campeggi
authors.forename: G
authors.initials: G
authors.lastname: Ploussard
authors.forename: Y
authors.initials: Y
authors.lastname: Allory
authors.forename: D
authors.initials: D
authors.lastname: Vordos
authors.forename: A
authors.initials: A
authors.lastname: Hoznek
authors.forename: A
authors.initials: A
authors.lastname: De la Taille
authors.forename: C-C
authors.initials: CC
authors.lastname: Abbou
authors.forename: L
authors.initials: L
authors.lastname: Salomon
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D005602:France; D006801:Humans; D010535:Laparoscopy; D008297:Male; D009361:Neoplasm Invasiveness; D011159:Population Surveillance; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology* / Q000601:surgery; D011468:Prostatectomy; D012669:Seminal Vesicles / Q000473:pathology