title: Efficient synthesis of esermethole and its analogues.
abstract: In this work, a general and flexible synthetic route towards the synthesis of pyrroloindoline alkaloids was developed. This new strategy features with a palladium mediated sequential arylation-allylation of o-bromoanilides and leads to the construction of oxindoles bearing a full carbon quaternary center. The cheap triphenylphosphine was proved to be a highly effective ligand for this one pot transformation. On the basis of this new method, esermethole and its analogues were synthesized.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, 650091, PR China.
authors.forename: Yongyun
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Dai
authors.forename: Jianping
authors.initials: J
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhang
mesh_terms: D015394:Molecular Structure; D010830:Physostigmine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C518152:esermethole; D010830:Physostigmine