title: [Progress of nanometer vector polyethylenimine applied in gene therapy].
abstract: Polyethylenimine (PEI) is a kind of nanometer nonviral vector frequently applied in gene transfection. It is simple and easy to prepare and to modify and relatively safe compared to viral vectors. In recent years, PEI has been utilized in many research areas for gene delivery to stem cells in vitro or targeted gene delivery to cells in the brain. This review reveals that the cytotoxicity and low transfection efficiency of PEI requires to be improved. However brain-targeted modification indicates the promising prospect of PEI for gene therapy in cerebrovascular diseases.
authors.affiliation: Department of Pathophysiology, Zhongshan School of Medicine, SUN Yat-sen University, Guangzhou 510080, China.
authors.forename: Xiaoai
authors.initials: X
authors.lastname: Chen
authors.forename: Yubin
authors.initials: Y
authors.lastname: Deng
mesh_terms: D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D033581:Stem Cell Transplantation / Q000379:methods*; D014162:Transfection / Q000379:methods
chemical_list: D011094:Polyethyleneimine