title: Histamine H(3) receptor (H(3)R) antagonists and inverse agonists in the treatment of sleep disorders.
abstract: After the discovery and characterization of the H(3)R and H(4)R receptors, they have become widely anticipated as potential therapeutic agents in the treatment of sleep disorders. In preliminary studies, histamine H(3) receptor (H(3)R) antagonists and inverse agonists have demonstrated promise in the treatment of sleep disorders associated with excessive daytime sleepiness. This review article summarizes the current research in this area and characteristics of H(3)R and H(3)R antagonists and inverse agonists in development.
authors.affiliation: Sound Sleep Health, Seattle, WA 98125, USA. mbroderick@soundsleephealth.com
authors.forename: Meredith
authors.initials: M
authors.lastname: Broderick
authors.forename: Tony
authors.initials: T
authors.lastname: Masri
mesh_terms: D000818:Animals; D006970:Disorders of Excessive Somnolence / Q000188:drug therapy* / Q000378:metabolism; D015195:Drug Design; D054314:Drug Inverse Agonism; D017442:Histamine Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D054828:Histamine H3 Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D018100:Receptors, Histamine H3 / Q000187:drug effects / Q000378:metabolism; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000378:metabolism
chemical_list: D017442:Histamine Agonists; D054828:Histamine H3 Antagonists; D018100:Receptors, Histamine H3