title: Differential levels of resistance to disease induction and development of relapsing experimental autoimmune encephalomyelitis in two H-2b-restricted mouse strains.
abstract: Besides the major histocompatibility complex (MHC) genes, background genes are believed to influence the encephalitogenicity of SJL(H-2(s)) and B10.S (H-2(s)) mice responding to myelin basic protein (MBP). A new mouse strain was constructed to study the effects of the SJL genetic background in mice responding to H-2(b)-restricted neuroantigens. Although the SJL.B (H-2(b)) mouse remained resistant to MBP in active EAE induction, the disease severity was uniformly higher in MOG-induced active EAE and in MBP-induced adoptive EAE when compared to those of B6 (H-2(b)) mice. Treatment of mice with anti-CD25 antibodies prior to immunization caused 60% of SJL.B mice to become susceptible to MBP-induced EAE while only 14% of B6 mice were converted. In addition, MOG-induced EAE in SJL.B mice followed a remitting-relapsing disease course while B6 mice only exhibited monophasic or chronic episodes. The new SJL.B mouse strain provides a valuable tool for studying EAE resistance and remitting-relapsing disease in H-2(b) mice.
authors.affiliation: Department of Immunology and Microbiology, Wayne State University, School of Medicine, Detroit, MI 48201, USA.
authors.forename: Jinzhu
authors.initials: J
authors.lastname: Li
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Zhao
authors.forename: Robert
authors.initials: R
authors.lastname: Skoff
authors.forename: Michael K
authors.initials: MK
authors.lastname: Shaw
authors.forename: Harley Y
authors.initials: HY
authors.lastname: Tse
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D004676:Myelin Basic Protein / Q000276:immunology / Q000633:toxicity; D010446:Peptide Fragments / Q000276:immunology / Q000633:toxicity; D013045:Species Specificity; D013997:Time Factors
chemical_list: D000906:Antibodies; D016207:Cytokines; D006183:H-2 Antigens; D053645:Interleukin-2 Receptor alpha Subunit; D004676:Myelin Basic Protein; D010446:Peptide Fragments