title: CNS activities of ethanol extract of aerial parts of Hygrophila difformis in mice.
abstract: The ethanol extract of aerial parts of Hygrophila difformis (EEHD) was tested for possible pharmacological effects on experimental animals. EEHD significantly potentiated the sleeping time of mice induced by standard hypnotics, viz. pentobarbital sodium, diazepam, and meprobamate in a dose dependent manner. EEHD showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. It also potentiated analgesia induced by morphine and pethidine in mice. Pretreatment with EEHD caused significant protection against strychnine and leptazol-induced convulsions. The behavioral studies on mice indicate CNS depressant activity of the ethanol extract of H. difformis.
authors.affiliation: Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj -757 086, Orissa, India. drdilip2003@yahoo.co.in
authors.forename: Dilipkumar
authors.initials: D
authors.lastname: Pal
authors.forename: Krishanu
authors.initials: K
authors.lastname: Samanta
mesh_terms: D027901:Acanthaceae; D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000494:pharmacology* / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry*; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D017288:Pain Threshold / Q000187:drug effects; D010433:Pentylenetetrazole; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects; D012997:Solvents / Q000737:chemistry*; D013331:Strychnine; D013997:Time Factors
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D013331:Strychnine; D019342:Acetic Acid; D010433:Pentylenetetrazole