title: Different vulnerability indicators for psychosis and their neuropsychological characteristics in the Northern Finland 1986 Birth Cohort.
abstract: This study is one of very few that has investigated the neuropsychological functioning of both familial and clinical high risk subjects for psychosis. Participants (N = 164) were members of the Northern Finland 1986 Birth Cohort in the following four groups: familial risk for psychosis (n = 62), clinical risk for psychosis (n = 20), psychosis (n = 13), and control subjects (n = 69). The neurocognitive performance of these groups was compared across 19 cognitive variables. The two risk groups did not differ significantly from controls, but differed from the psychosis group in fine motor function. Neuropsychological impairments were not evident in a non-help-seeking high-risk sample.
authors.affiliation: Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, Oulu, Finland.
authors.forename: Sari
authors.initials: S
authors.lastname: Mukkala
authors.forename: Tuula
authors.initials: T
authors.lastname: Ilonen
authors.forename: Tanja
authors.initials: T
authors.lastname: Nordström
authors.forename: Jouko
authors.initials: J
authors.lastname: Miettunen
authors.forename: Jukka
authors.initials: J
authors.lastname: Loukkola
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Barnett
authors.forename: Graham K
authors.initials: GK
authors.lastname: Murray
authors.forename: Erika
authors.initials: E
authors.lastname: Jääskeläinen
authors.forename: Pirjo
authors.initials: P
authors.lastname: Mäki
authors.forename: Anja
authors.initials: A
authors.lastname: Taanila
authors.forename: Irma
authors.initials: I
authors.lastname: Moilanen
authors.forename: Peter B
authors.initials: PB
authors.lastname: Jones
authors.forename: Markus
authors.initials: M
authors.lastname: Heinimaa
authors.forename: Juha
authors.initials: J
authors.lastname: Veijola
mesh_terms: D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D015331:Cohort Studies; D056344:Executive Function / Q000502:physiology; D005192:Family Health; D005260:Female; D005387:Finland; D006801:Humans; D007360:Intelligence / Q000502:physiology; D007858:Learning; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications* / Q000523:psychology*; D055815:Young Adult