title: Rare cause of dysphagy: giant polypoid esophageal well-differentiated liposarcoma.
abstract: Liposarcoma represents one of the most frequent (10-20%) malignant mesenchymal tumors in the adult, affecting mostly the soft tissue of extremities, the trunk or the retroperitoneum. This tumor type occurs exceptionally rarely in the gastrointestinal tract with only few cases described in the literature. In this case we present a 73-year-old male patient who was admitted due to loss of weight, anorexia and postprandial emesis with dysphagy. Gastrographin esophagography failed to make precise diagnostics. CT scan of the upper gastrointestinal tract revealed a large esophageal tumor filling out the whole length of the esophagus. The tumor was removed by parasternocleidomastoidal approach with a stapler. Histopathological examination revealed a well-differentiated liposarcoma (grade I). Well-differentiated liposarcomas are characterised by amplified material of the 12q13-15 chromosomal region, present in the form of giant or ring chromosomes and leading to the overexpression of MDM2 and CDK4 genes. MDM2 and CDK4 proteins can be detected immunhistochemically, which was the case in the reported tumor. Overexpression of these proteins leads to suppression of tumor suppressor genes, leading to increased cell survival.
authors.affiliation: Department of Surgery, University Hospital of Zürich, Zürich, Switzerland.
authors.forename: Ladislav
authors.initials: L
authors.lastname: Mica
authors.forename: Duri
authors.initials: D
authors.lastname: Gianom
authors.forename: Beata
authors.initials: B
authors.lastname: Bode
authors.forename: Peter
authors.initials: P
authors.lastname: Jaklin
authors.forename: Albert
authors.initials: A
authors.lastname: Hollinger