title: Two cases of single-stage lip and nostril reconstruction in holoprosencephaly.
abstract: Holoprosencephaly is a rare disorder of embryological development that presents with midline clefting of the lip. The incidence has been estimated at approximately 1 in 15,000. Previously, infants with severe holoprosencephaly were thought to die within 1-2 years of birth and seldom to benefit from surgery. Survival has increased with improved perinatal care and support services. Parents often request complete cheiloplasty, because the presence of a columella greatly influences aesthetic outcome. The authors report two cases of simultaneous columella reconstruction with cheiloplasty.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Wakayama Medical University, Wakayama, Japan. n-morita@wakayama-med.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Morita
authors.forename: Y
authors.initials: Y
authors.lastname: Morita
authors.forename: Y
authors.initials: Y
authors.lastname: Taenaka
authors.forename: N
authors.initials: N
authors.lastname: Kimoto
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
authors.forename: T
authors.initials: T
authors.lastname: Oomata
mesh_terms: D002971:Cleft Lip / Q000601:surgery; D002972:Cleft Palate / Q000601:surgery; D005260:Female; D016142:Holoprosencephaly / Q000601:surgery*; D006801:Humans; D007223:Infant; D008046:Lip / Q000601:surgery*; D008297:Male; D055171:Nasal Cartilages / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*