title: Expanding the chiral pool: oxidation of meta-bromobenzoic acid by R. eutrophus B9 allows access to new reaction manifolds.
abstract: Metabolism of meta-bromobenzoic acid by the blocked mutant Ralstonia eutrophus B9 affords an enantiopure dearomatised halodiene-diol which we demonstrate is a versatile chiron for organic synthesis. The presence of the halogen leads to reactivity that is distinct to that observed for the non-halogenated analogue and also serves as a synthetic handle for further functionalisation.
authors.affiliation: Doctoral Training Centre in Sustainable Chemical Technologies, University of Bath, Bath, UK.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Griffen
authors.forename: Amélie M
authors.initials: AM
authors.lastname: Le Coz
authors.forename: Gabriele
authors.initials: G
authors.lastname: Kociok-Köhn
authors.forename: Monika Ali
authors.initials: MA
authors.lastname: Khan
authors.forename: Alan J W
authors.initials: AJ
authors.lastname: Stewart
authors.forename: Simon E
authors.initials: SE
authors.lastname: Lewis
mesh_terms: D001970:Bromobenzoates / Q000737:chemistry* / Q000378:metabolism*; D020118:Cupriavidus necator / Q000378:metabolism*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D001970:Bromobenzoates