title: Synthesis, characterization and biological evaluation of some 16E-arylidene androstane derivatives as potential anticancer agents.
abstract: A series of new 16E-arylidene androstane derivatives were synthesized and characterized. The new compounds were screened for their anticancer activities against the human cancer cell lines SW480, A549, HepG2 and HeLa in vitro using the MTT assay. The results of the in vitro study showed that a number of compounds have shown IC(50) values lower than 20 μM against the four cancer cell lines.
authors.affiliation: State Key Laboratory of Virology, College of Pharmacy, Wuhan University, Wuhan 430072, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Guo
authors.forename: Haotian
authors.initials: H
authors.lastname: Wu
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.forename: Yuling
authors.initials: Y
authors.lastname: Xiao
authors.forename: Hans-Josef
authors.initials: HJ
authors.lastname: Altenbach
authors.forename: Guofu
authors.initials: G
authors.lastname: Qiu
authors.forename: Hao
authors.initials: H
authors.lastname: Hu
authors.forename: Zhongyuan
authors.initials: Z
authors.lastname: Wu
authors.forename: Xianran
authors.initials: X
authors.lastname: He
authors.forename: Dingshan
authors.initials: D
authors.lastname: Zhou
authors.forename: Xianming
authors.initials: X
authors.lastname: Hu
mesh_terms: D000731:Androstanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship
chemical_list: D000731:Androstanes; D000970:Antineoplastic Agents; C033936:androstane