title: Plasma triglycerides after oral glucose load specifically associate with metabolic risk markers in healthy type 2 diabetes offspring.
abstract: OBJECTIVE
  To assess the potential of plasma triglycerides measured after glucose load as biomarker for insulin resistance and cardiovascular risk.
  
  
  METHODS
  An oral glucose tolerance test (OGTT, n=91) was performed in healthy type 2 diabetes offspring. Plasma lipids, lipoproteins, glucose and hormones were quantified in fasting and post-challenge samples.
  
  
  RESULTS
  During the OGTT total plasma triglycerides decreased in most subjects, however, they increased in some individuals and this increase was strongly associated with metabolic risk factors. Subjects with increasing triglycerides (n=18) were more obese and insulin resistant than those with the most pronounced triglyceride decrease (n=18), as indicated by higher HOMA-IR, BMI and waist circumference. Correlation analysis (n=91) demonstrated that the changes of total plasma and VLDL-associated triglycerides between 0 h and 2 h (Δ-TG, Δ-VLDL-T) were strongly associated with risk factors. Δ-TG, and especially Δ-VLDL-T, correlated better than fasting triglycerides with waist circumference, waist-to-hip ratio and fasting glucose. The correlations remained significant after adjustment for gender, age and HDL cholesterol.
  
  
  CONCLUSIONS
  The observed increase of triglycerides after glucose load in subjects with signs of insulin resistance and obesity suggests that post-glucose triglyceride change is a potential novel biomarker for early detection of metabolic risk. The specific association of post-glucose triglyceride change with abdominal obesity and fasting glucose suggests a link to hepatic steatosis and insulin resistance.
authors.affiliation: Department of Biochemistry and Molecular Biology II, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Vossen
authors.forename: Klaus
authors.initials: K
authors.lastname: Tödter
authors.forename: Christiane
authors.initials: C
authors.lastname: Altenburg
authors.forename: Ulrike
authors.initials: U
authors.lastname: Beisiegel
authors.forename: Ludger
authors.initials: L
authors.lastname: Scheja
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis*; D005192:Family Health; D005234:Fatty Liver / Q000473:pathology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010290:Parents; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D014280:Triglycerides