title: Anaplastic transformation of differentiated thyroid carcinoma.
abstract: Anaplastic thyroid cancer (ATC) is one of the most aggressive malignancies that arise from transformation of pre-existing differentiated thyroid cancer (DTC). However, the carcinogenic mechanism of anaplastic transformation remains unclear. We describe a case for huge goiter diagnosed as papillary thyroid carcinoma, which underwent thyroidectomy. The final histology showed anaplastic transformation. The clinical and possible etiological aspects are discussed.
authors.affiliation: Department of Surgery, College of Medicine and King Khalid University Hospital King Saud University, Riyadh, Saudi Arabia.
authors.forename: Gamal
authors.initials: G
authors.lastname: Khairy