title: Fibrogenesis in nonalcoholic steatohepatitis.
abstract: Nonalcoholic steatohepatitis includes a wide spectrum of liver injury, ranging from simple inflammation to fibrosis and cirrhosis. Whereas simple steatosis has a benign clinical course, steatohepatitis is a recognized cause of progressive liver fibrosis and can develop, in some circumstances, into cirrhosis. The main cause of fibrogenesis is represented by the activation of myofibroblastic cells, which then start to produce matrix filaments. Matrix-producing cells, although mainly constituted of hepatic stellate cells, may have a different origin in the liver. This article will provide information on the sources of matrix-producing cells and the mechanisms involved in the development of fibrogenesis, with particular attention paid to the pathophysiological implications leading from steatohepatitis to fibrosis and cirrhosis.
authors.affiliation: Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Samuele
authors.initials: S
authors.lastname: De Minicis
authors.forename: Gianluca
authors.initials: G
authors.lastname: Svegliati-Baroni
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism*; D055166:Hepatic Stellate Cells / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism*; D051379:Mice; D058628:Myofibroblasts / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease; D018384:Oxidative Stress / Q000502:physiology; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D054392:Adipokines; D016207:Cytokines; D018160:Receptors, Cytoplasmic and Nuclear; D051193:Toll-Like Receptors