title: Synthesis of patterned nanogold and mesoporous CoFe2O4 nanoparticle assemblies and their application in clinical immunoassays.
abstract: Herein, we describe a facile and feasible synthesis method for patterning nanogold particles onto magnetic mesoporous CoFe(2)O(4) nanostructures (Au-MMNs) by using poly(vinyl pyrrolidone) (PVP) as cross-linker. Initially, mesoporous CoFe(2)O(4) nanoparticles were initially synthesized with a thermal decomposition method by using mesoporous silica nanoparticles as templates, and then nanometre-sized gold particles were produced through the in situ reduction of the Au(III) on the PVP-functionalized CoFe(2)O(4). The as-prepared Au-MMNs were characterized by transmission electron microscopy (TEM), N(2) adsorption-desorption isotherms, UV-visible adsorption spectrometer, vibrating sample magnetometer (VSM) and X-ray photoelectron spectroscopy (XPS). Furthermore, we also demonstrate the conjugation capacity of the synthesized Au-MMNs toward biomolecules by using quartz crystal microbalance (QCM), and the possible application in the electrochemical immunoassays. Experimental results indicated that the resulting Au-MMNs display good conjugation capability toward the biomolecules, and excellent analytical properties for determination of target molecules.
authors.affiliation: Key Laboratory of Analysis and Detection for Food Safety (Ministry of Education), Department of Chemistry, Fuzhou University, Fuzhou, 350108, China.
authors.forename: Bingqian
authors.initials: B
authors.lastname: Liu
authors.forename: Qunfang
authors.initials: Q
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Yuling
authors.initials: Y
authors.lastname: Cui
authors.forename: Huafeng
authors.initials: H
authors.lastname: Chen
authors.forename: Guonan
authors.initials: G
authors.lastname: Chen
authors.forename: Dianping
authors.initials: D
authors.lastname: Tang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003035:Cobalt / Q000737:chemistry*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005290:Ferric Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D007118:Immunoassay / Q000295:instrumentation*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D003035:Cobalt; D006046:Gold