title: Trends in gastrointestinal bleeding in the Region of Valencia (2000-2005). Relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medication.
abstract: OBJECTIVE
  To describe 2000-2005 time trends of prescription for NSAIDs, proton pump inhibitors (PPIs) and hospital admissions for gastrointestinal (GI) bleeding.
  
  
  METHODS
  Time series analysis of gastrointestinal (GI) bleeding admission and drugs' Defined Daily Dose per 1000 people per day (DDD/1000/day) in the Region of Valencia, Spain, from January 2000 to December 2005.
  
  
  RESULTS
  Dispensation of NSAIDs went from 42.7 DDD/1000 people/day in 2000 to 58.3 DDD/1000 people/day in 2005. During the same period, dispensation of PPIs went from 26.3 DDD/1000 people/day to 68.5 DDD/1000 people/day (both are statistically significant). The rate of hospitalisations for gastrointestinal bleeding during this period oscillated between 142 and 126 admission per 100 000 inhabitants/year. No year showed significant differences compared to 2000.
  
  
  CONCLUSIONS
  A substantial increase in the NSAID use from 2000 to 2005 was not accompanied by changes in GI bleeding hospitalisation rates in Valencia, but GI bleeding rates continued to be high, suggesting a need to improve NSAIDs use.
authors.affiliation: Centro Superior de Investigación en Salud Pública, Valencia, Spain. peiro_bor@gva.es
authors.forename: S
authors.initials: S
authors.lastname: Peiró Moreno
authors.forename: P
authors.initials: P
authors.lastname: Cervera-Casino
authors.forename: G
authors.initials: G
authors.lastname: Sanfélix-Gimeno
authors.forename: J
authors.initials: J
authors.lastname: Librero López
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000600:supply & distribution; D003132:Commerce / Q000706:statistics & numerical data; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000600:supply & distribution; D013030:Spain / Q000453:epidemiology; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D054328:Proton Pump Inhibitors