title: [A clinical study on changes of EGF in serum before and after endoscopic surgery in patients with chronic sinusitis disease].
abstract: OBJECTIVE
  To evaluate the changes of epidermal growth factor (EGF) in serum before and after endoscopic surgery in patients with chronic sinusitis, and then to explore its clinical significance.
  
  
  METHODS
  Serum was collected before and after operation and EGF concentrations were measured by the radioimmunoassay at different times.
  
  
  RESULTS
  EGF levels in patients with chronic sinusitis (1.24 +/- 0.41) microg/L were higher than that in control group (0.92 +/- 0.23) microg/L, but there were no significantly difference between them (P > 0.05). The concentrations of EGF were reduced after surgery, and the lowest were evaluated after 4 weeks. Significant difference of EGF concentrations were found between before and 4 weeks after operation (P < 0.01). The concentration of EGF were raised 6 weeks after surgery, and returned to normal after 8 weeks.
  
  
  CONCLUSIONS
  The changes of EGF in serum before and after endoscopic surgery may relate with the epithelization process of sinus mucosa after endoscopic surgery.
authors.affiliation: Department of Otolaryngology, the Centrol Hospital of Xiangyang, Xiangyang, 441021, China. wangpju@sohu.com
authors.forename: Pengju
authors.initials: P
authors.lastname: Wang
authors.forename: Yin
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D004724:Endoscopy; D004815:Epidermal Growth Factor / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012852:Sinusitis / Q000097:blood* / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004815:Epidermal Growth Factor