title: Evaluation of male-mediated reproductive toxic effects of methamidophos in the mouse.
abstract: The reproductive toxicity of the insecticide methamidophos was studied in male mice. Adult male mice were treated by gavage with methamidophos at doses of 0, 1, 2 and 3 mg kg(-1) day(-1) for 4 weeks before mating with untreated females. Brain and skeletal muscle acetylcholinesterase activity was inhibited in the middle- and high-treated groups. Methamidophos treatment was associated with a decreased number of live foetuses and an increased number of dead and resorption foetuses at 2 and 3 mg kg(-1) day(-1) treated groups. The per cent morphologically normal spermatozoa were affected in the 2 and 3 mg kg(-1) day(-1) dose groups; however, sperm motility and count were decreased in the same treated groups compared to the control. Histological examination of brain, muscles, testes and epididymis revealed histological abnormalities in a dose-dependent manner. The current study demonstrated adverse effects of male methamidophos exposure on pregnancy outcome with effects on sperm parameters at 2 and 3 mg kg(-1) day(-1) .
authors.affiliation: Department of Pesticide Chemistry and Toxicology, Alexandria University, Alexandria, Egypt. aminafarag2002@yahoo.com
authors.forename: A T
authors.initials: AT
authors.lastname: Farag
authors.forename: A H
authors.initials: AH
authors.lastname: Radwan
authors.forename: M H
authors.initials: MH
authors.lastname: Eweidah
authors.forename: R H
authors.initials: RH
authors.lastname: Elmazoudy
authors.forename: Abd El-Khaliek
authors.initials: Ael-K
authors.lastname: El-Sebae
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects; D000818:Animals; D004435:Eating / Q000187:drug effects; D004822:Epididymis / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012098:Reproduction / Q000187:drug effects*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; C014655:methamidophos; D000110:Acetylcholinesterase