title: Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population.
abstract: To identify association of IL18-607 C/A and -137 G/C polymorphism with susceptibility to gout in Chinese Han male population, We evaluate the genetic contribution of the IL18-607 C/A and -137 G/C polymorphism in 202 gout male patients and 493 gout-free control of Chinese Han population by allele-specific polymerase chain reaction assay. Our results reveal no significant association between the polymorphisms -607C/A and -137G/C in IL18 with gout. Our study might suggest that -607 C/A and -137 G/C polymorphisms in the promoter of IL18 are not associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population.
authors.affiliation: Gout Laboratory, Medical School Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Changgui
authors.initials: C
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Yuan
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Han
authors.forename: Nan
authors.initials: N
authors.lastname: Chu
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006073:Gout / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D020382:Interleukin-18