title: Suppression of A549 lung cancer cell migration by precursor let-7g microRNA.
abstract: Let-7g miRNAs, short non-coding RNAs approximately 21 nucleotides long, repress protein translation by binding to the 3'UTR of target mRNAs. Aberrant expression of let-7g is associated with the poor prognosis of lung cancer patients. Compared to normal lung cells, let-7g expression is absent in non-small cell lung cancer (NSCLC) cells. Furthermore, K-Ras and HMGA2 are well known as targets of let-7g. In this study, we evaluated the potential role of precursor (pre)-let-7g in lung cancer cell metastasis, focusing on the two targets of let-7g, HMGA2 and K-Ras. We found that pre-let-7g inhibited the migration of A549 lung cancer cells through HMGA2-mediated E2F1 down-regulation. Thus, our results suggest that pre-let-7g could be used as a suitable target for the suppression of lung cancer cell migration.
authors.affiliation: Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
authors.forename: Sungjin
authors.initials: S
authors.lastname: Park
authors.forename: Arash
authors.initials: A
authors.lastname: Minai-Tehrani
authors.forename: Cheng-Xiong
authors.initials: CX
authors.lastname: Xu
authors.forename: Seung-Hee
authors.initials: SH
authors.lastname: Chang
authors.forename: Min-Ah
authors.initials: MA
authors.lastname: Woo
authors.forename: Mi-Suk
authors.initials: MS
authors.lastname: Noh
authors.forename: Eun-Sun
authors.initials: ES
authors.lastname: Lee
authors.forename: Hwang-Tae
authors.initials: HT
authors.lastname: Lim
authors.forename: Gil-Hwan
authors.initials: GH
authors.lastname: An
authors.forename: Kee-Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Ha-Jung
authors.initials: HJ
authors.lastname: Sung
authors.forename: George R
authors.initials: GR
authors.lastname: Beck
authors.forename: Myung-Haing
authors.initials: MH
authors.lastname: Cho