title: Pachydermatous eosinophilic dermatitis.
abstract: A case is presented of a female Caucasian patient with chronic peripheral blood eosinophilia and unusual skin manifestations. Within a couple of years, the patient developed multiple hyperkeratotic and hyperpigmented papules and plaques all over the body, palmoplantar keratoderma, pachydermia of acral parts of the body, and generalized pruritus. Generalized lymphadenopathy appeared. Other relevant symptoms were persistent peripheral blood hypereosinophilia and increased level of total IgE. The patient was diagnosed with a very rare condition, pachydermatous eosinophilic dermatitis, and was administered combined therapy with dapsone, oral methylprednisolone and fexophenadine. After one month of treatment, the skin changes markedly improved.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland. jsalomon@op.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Salomon
authors.forename: Rafał
authors.initials: R
authors.lastname: Białynicki-Birula
authors.forename: Zdzisław
authors.initials: Z
authors.lastname: Woźniak
authors.forename: Eugeniusz
authors.initials: E
authors.lastname: Baran
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001707:Biopsy, Needle; D003872:Dermatitis / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D007645:Keratoderma, Palmoplantar / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D007642:Keratosis / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D006633:Histamine Antagonists; D017255:Acitretin