title: Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis.
abstract: Tuberculosis is a leading cause of death worldwide. Resistance of Mycobacterium to antibiotics can make treatments less effective in some cases. We tested selected oligopeptoids--previously reported as mimics of natural host defense peptides--for activity against Mycobacterium tuberculosis and assessed their cytotoxicity. A tetrameric, alkylated, cationic peptoid (1-C13(4mer)) was most potent against M. tuberculosis and least cytotoxic, whereas an unalkylated analogue, peptoid 1(4mer), was inactive. Peptoid 1-C13(4mer) thus merits further study as a potential antituberculosis drug.
authors.affiliation: Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
authors.forename: Rinki
authors.initials: R
authors.lastname: Kapoor
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Eimerman
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Hardy
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Cirillo
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Contag
authors.forename: Annelise E
authors.initials: AE
authors.lastname: Barron
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009163:Mycobacterium bovis / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D034444:Peptoids / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D034444:Peptoids