title: 2-Aryl-1,4-naphthoquinone-1-oxime methyl ethers: their cytotoxic activity.
abstract: Preliminary examination for the structure-activity relationship of quinone monooxime derivatives on cytotoxicity against HeLa S3 cell and further trials using eight different cell lines suggested that 2-aryl-6,7-methylenedioxy-1,4-naphthoquinone-1-oxime methyl ethers, carrying 2-methoxy-4,5-methylenedioxyphenyl, 7-methoxy-2-methylbenzofuran-4-yl, and 2-methoxycarbonyl-3,4-dimethoxyphenyl as the 2-aryl substituent, were potential candidates for anti-cancer drugs.
authors.affiliation: Department of Medicinal Organic Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi, Inage, Chiba, Japan. benti@faculty.chiba-u.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Tatsuru
authors.initials: T
authors.lastname: Saito
authors.forename: Ayako
authors.initials: A
authors.lastname: Kurosawa
authors.forename: Toshiko
authors.initials: T
authors.lastname: Watanabe
authors.forename: Sakiko
authors.initials: S
authors.lastname: Maruyama
authors.forename: Yuh-ichiro
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Ryota
authors.initials: R
authors.lastname: Yamada
authors.forename: Hiroko
authors.initials: H
authors.lastname: Okuzawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sato
authors.forename: Koichi
authors.initials: K
authors.lastname: Ueno
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008738:Methyl Ethers / Q000737:chemistry*; D009285:Naphthoquinones / Q000737:chemistry* / Q000633:toxicity; D010091:Oximes / Q000737:chemistry* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D008738:Methyl Ethers; D009285:Naphthoquinones; D010091:Oximes; C035342:1,4-naphthoquinone