title: [Hormones of adipose tissue in diabetes mellitus and its complications (review of literature and the authors'own data)].
abstract: The contemporary ideas on endocrine function of the adipose tissue and its role in pathogenesis of diabetes mellitus and insulin resistance associated with it and the metabolic syndrome are shown in the review. A change in the life style (excessive and irrational nutrition, insufficient physical loading, psychological disorders) and also the reduction of genetic and immunologic controlling mechanisms contribute to the development of obesity, that is now considered as low-grade inflammation. An increased number of small size adipocytes and macrophages of the adipose tissue begin to secrete an increase number of proinflammatory adipocytokines and chemokines that result in the inflammatory and metabolic stress accompanied by the stimulation of signal pathways, leading to increased insulin requirement, on the one hand, and promoting to the beta-cell death, on the other hand. The role of some adipocytokines such as IL-6, TNF-alpha, leptin, adiponectin, visfatin and resistin was demonstrated in these processes.
authors.forename: K P
authors.initials: KP
authors.lastname: Zak
authors.forename: I N
authors.initials: IN
authors.lastname: Kondratskaia
authors.forename: V V
authors.initials: VV
authors.lastname: Popova
mesh_terms: D054392:Adipokines / Q000276:immunology / Q000378:metabolism*; D000273:Adipose Tissue / Q000276:immunology / Q000378:metabolism*; D048909:Diabetes Complications / Q000276:immunology / Q000378:metabolism; D003920:Diabetes Mellitus / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance / Q000276:immunology
chemical_list: D054392:Adipokines