title: Relation of uric acid with components of metabolic syndrome before and after Roux-en-Y gastric bypass in morbidly obese subjects.
abstract: OBJECTIVE
  The purpose of the study was to investigate the prevalence of hyperuricemia in morbidly obese subjects before and after Roux-en-Y gastric bypass (RYGBP) and its relationship with metabolic syndrome abnormalities.
  
  
  METHODS
  We evaluated 420 morbidly obese patients. Pre and postoperative (8 months after RYGBP) blood samples were drawn. Obese patients underwent laparoscopic RYGBP and after eight months all the tests were repeated.
  
  
  RESULTS
  The overall prevalence of hyperuricemia was 34.28%. Hyperuricemia was more common in men than in women (51.72 vs. 29.72%; p = 0.0002). Men with hyperuricemia were more likely to have diabetes (p = 0.034) and more elevated fasting plasma glucose levels (p = 0.027). Women with hyperuricemia were more likely to have hypertension (p = 0.003), metabolic syndrome (p = 0.001), elevated triglycerides (p = 0.001) and GGT (p = 0.009), and decreased HDL (p = 0.011). After surgery, uric acid levels decreased from 5.60 ± 1.28 to 4.23 ± 1.20 (p < 0.0001). The prevalence of hyperuricemia decreased from 33.6% to 6.4% (p < 0.0001), in men from 48.3% to 17.2% (p < 0.0001) and in women from 29.7% to 3.6% (p < 0.0001).
  
  
  CONCLUSIONS
  Concentrations of uric acid were associated with the prevalence of metabolic abnormalities in this sample of morbidly obese patients. Also, weight loss after RYGBP can reduce uric acid levels and the prevalence of hyperuricemia.
authors.affiliation: Division of Clinical and Surgical Treatment of Obesity, Faculdade de Medicina do ABC, Santo André, SP, Brazil. aryserpa@terra.com.br
authors.forename: Ary
authors.initials: A
authors.lastname: Serpa Neto
authors.forename: Felipe Martin Bianco
authors.initials: FM
authors.lastname: Rossi
authors.forename: Leonardo Guedes Moreira
authors.initials: LG
authors.lastname: Valle
authors.forename: Gabriel Kushiyama
authors.initials: GK
authors.lastname: Teixeira
authors.forename: Marçal
authors.initials: M
authors.lastname: Rossi
mesh_terms: D000293:Adolescent; D000328:Adult; D004812:Epidemiologic Methods; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D011184:Postoperative Period; D057234:Preoperative Period; D017678:Sex Distribution; D014527:Uric Acid / Q000097:blood*; D015431:Weight Loss / Q000502:physiology; D055815:Young Adult
chemical_list: D014527:Uric Acid