title: Gastric motor disturbances in patients with idiopathic rapid gastric emptying.
abstract: BACKGROUND
  The mechanisms of 'idiopathic' rapid gastric emptying, which are associated with functional dyspepsia and functional diarrhea, are not understood. Our hypotheses were that increased gastric motility and reduced postprandial gastric accommodation contribute to rapid gastric emptying.
  
  
  METHODS
  Fasting and postprandial (300kcal nutrient meal) gastric volumes were measured by magnetic resonance imaging (MRI) in 20 healthy people and 17 with functional dyspepsia; seven had normal and 10 had rapid gastric emptying. In 17 healthy people and patients, contractility was analyzed by spectral analysis of a time-series of gastric cross-sectional areas. Logistic regression models analyzed whether contractile parameters, fasting volume, and postprandial volume change could discriminate between health and patients with normal or rapid gastric emptying.
  
  
  RESULTS
  While upper gastrointestinal symptoms were comparable, patients with rapid emptying had a higher (P=0.002) body mass index than normal gastric emptying. MRI visualized propagating contractions at ∼3cpm in healthy people and patients. Compared with controls (0.32±0.04, Mean±SEM), the amplitude of gastric contractions in the entire stomach was higher (OR 4.1, 95% CI 1.2-14.0) in patients with rapid (0.48±0.06), but not normal gastric emptying (0.20±0.06). Similar differences were observed in the distal stomach. However, the propagation velocity, fasting gastric volume, and the postprandial volume change were not significantly different between patients and controls.
  
  
  CONCLUSIONS
  MRI provides a non-invasive and refined assessment of gastric volumes and contractility in humans. Increased gastric contractility may contribute to rapid gastric emptying in functional dyspepsia.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. bharucha.adil@mayo.edu
authors.forename: A E
authors.initials: AE
authors.lastname: Bharucha
authors.forename: A
authors.initials: A
authors.lastname: Manduca
authors.forename: D S
authors.initials: DS
authors.lastname: Lake
authors.forename: J
authors.initials: J
authors.lastname: Fidler
authors.forename: P
authors.initials: P
authors.lastname: Edwards
authors.forename: R C
authors.initials: RC
authors.lastname: Grimm
authors.forename: A R
authors.initials: AR
authors.lastname: Zinsmeister
authors.forename: S J
authors.initials: SJ
authors.lastname: Riederer
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004415:Dyspepsia / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D009929:Organ Size; D019518:Postprandial Period; D012044:Regression Analysis; D013270:Stomach / Q000473:pathology / Q000503:physiopathology*