title: Auxin triggers a genetic switch.
abstract: Cell specification in development requires robust gene-regulatory responses to transient signals. In plants, the small signalling molecule auxin has been implicated in diverse developmental processes. Auxin promotes the degradation of AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) inhibitors that prevent AUXIN RESPONSE FACTOR (ARF) transcription factors from regulating their target genes. However, the precise role of auxin in patterning has remained unclear, the view of auxin acting as a morphogen is controversial and the transcriptional control of the ARF genes themselves is barely explored. Here, we demonstrate by experimental and computational analyses that the Arabidopsis ARF protein MONOPTEROS (MP) controls its own expression and the expression of its AUX/IAA inhibitor BODENLOS (BDL), with auxin acting as a threshold-specific trigger by promoting the degradation of the inhibitor. Our results suggest a general mechanism for how the transient accumulation of auxin activates self-sustaining or hysteretic feedback systems of interacting auxin-response proteins that, similarly to other genetic switches, result in unequivocal developmental responses.
authors.affiliation: Department of Cell Biology, Max Planck Institute for Developmental Biology, Spemannstraße 35, D-72076 Tübingen, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Lau
authors.forename: Ive
authors.initials: I
authors.lastname: De Smet
authors.forename: Martina
authors.initials: M
authors.lastname: Kolb
authors.forename: Hans
authors.initials: H
authors.lastname: Meinhardt
authors.forename: Gerd
authors.initials: G
authors.lastname: Jürgens
mesh_terms: D017360:Arabidopsis / Q000235:genetics*; D017343:Genes, Plant; D007210:Indoleacetic Acids / Q000378:metabolism*
chemical_list: D007210:Indoleacetic Acids