title: Lack of association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis: a meta-analysis.
abstract: OBJECTIVE
  Genetic background may influence susceptibility pulmonary tuberculosis. The evidence for an association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis remains inconclusive. In order to provide a more precise estimate of this association, a meta-analysis was performed.
  
  
  METHODS
  Databases, including PUBMED, OVID, ScienceDirect, SpringerLink, EBSCO and EMBASE were searched for publications that met the inclusion criteria. A fixed effect model was used to estimate pooled OR with 95% CI for the association between susceptibility to pulmonary tuberculosis and the P2X7 receptor A1513C polymorphism. The chi-squared-based Q-test was used to test the heterogeneity hypothesis. Begg's test and Egger's test were used to check publication bias.
  
  
  RESULTS
  Six published case-control studies that investigated the association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis in 2525 subjects were included in this meta-analysis. The heterogeneity hypothesis test did not reveal any heterogeneity. Begg's test and Egger's test did not detect obvious publication bias among the included studies. This meta-analysis indicated that there was no significant association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis (AC vs AA model: OR 1.12, 95% CI: 0.93-1.35; CC vs AA model: OR 1.45, 95% CI: 0.92-2.28; AC + CC vs AA model: OR 1.15, 95% CI: 0.96-1.13; CC vs AC + AA model: OR 1.42, 95% CI: 0.90-2.23).
  
  
  CONCLUSIONS
  This meta-analysis of six studies involving 2525 subjects suggested that the P2X7 receptor A1531C polymorphism is not associated with susceptibility to pulmonary tuberculosis.
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China.
authors.forename: Xiwen
authors.initials: X
authors.lastname: Wang
authors.forename: Huaping
authors.initials: H
authors.lastname: Xiao
authors.forename: Haibing
authors.initials: H
authors.lastname: Lan
authors.forename: Chen
authors.initials: C
authors.lastname: Mao
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D017594:Publication Bias; D058486:Receptors, Purinergic P2X7 / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D058486:Receptors, Purinergic P2X7