title: Galectin-3 gene (LGALS3) +292C allele is a genetic predisposition factor for rheumatoid arthritis in Taiwan.
abstract: Galectin-3 is a beta-galactoside-binding lectin which is involved in modulating inflammation and apoptosis. Elevated expression of galectin-3 has been demonstrated in synovium of rheumatoid arthritis (RA). The aim of our study is to investigate the genetic polymorphisms of galectin-3 in association with RA. Polymorphisms of galectin-3 gene (LGALS3) were compared between 151 RA patients and 182 healthy subjects in Taiwan. Variants at two LGALS3 single nucleotide polymorphism (SNP) sites (rs4644 and rs4652, corresponding to LAGLS3 +191 and +292) were genotyped by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) and sequence-specific oligonucleotide probe hybridization, respectively. The allelic carriage of LGALS3 +292C was increased in patients with RA (66.9% in RA vs. 52.7% in controls, odds ratio=1.8, 95% confidence interval=1.2-2.8, p=0.009). These results implicate that the genetic polymorphisms in galectin-3 gene may contribute to development of RA.
authors.affiliation: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China.
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Hu
authors.forename: Sheng-Kai
authors.initials: SK
authors.lastname: Chang
authors.forename: Chien-Sheng
authors.initials: CS
authors.lastname: Wu
authors.forename: Wei-I
authors.initials: WI
authors.lastname: Tsai
authors.forename: Ping-Ning
authors.initials: PN
authors.lastname: Hsu
mesh_terms: D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000235:genetics*; D005260:Female; D037502:Galectin 3 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan / Q000453:epidemiology
chemical_list: D037502:Galectin 3; D015345:Oligonucleotide Probes