title: Insulin resistance influences central opioid activity in polycystic ovary syndrome.
abstract: This pilot study describes a relationship between insulin resistance and μ-opioid neurotransmission in limbic appetite and mood-regulating regions in women with polycystic ovary syndrome (PCOS), suggesting that insulin-opioid interactions may contribute to behavioral and reproductive pathologies of PCOS. We found that [1] patients with PCOS who are insulin-resistant (n = 7) had greater limbic μ-opioid receptor availability (nondisplaceable binding potential) than controls (n = 5); [2] receptor availability was correlated with severity of insulin resistance; and [3] receptor availability normalized after insulin-regulating treatment.
authors.affiliation: Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Berent-Spillson
authors.forename: Tiffany
authors.initials: T
authors.lastname: Love
authors.forename: Rodica
authors.initials: R
authors.lastname: Pop-Busui
authors.forename: MaryFran
authors.initials: M
authors.lastname: Sowers
authors.forename: Carol C
authors.initials: CC
authors.lastname: Persad
authors.forename: Kathryn P
authors.initials: KP
authors.lastname: Pennington
authors.forename: Aimee D
authors.initials: AD
authors.lastname: Eyvazaddeh
authors.forename: Vasantha
authors.initials: V
authors.lastname: Padmanabhan
authors.forename: Jon-Kar
authors.initials: JK
authors.lastname: Zubieta
authors.forename: Yolanda R
authors.initials: YR
authors.lastname: Smith
mesh_terms: D000328:Adult; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002250:Carbon Radioisotopes; D016022:Case-Control Studies; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007333:Insulin Resistance; D008279:Magnetic Resonance Imaging; D008687:Metformin / Q000627:therapeutic use; D008824:Michigan; D010865:Pilot Projects; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D049268:Positron-Emission Tomography; D017450:Receptors, Opioid, mu / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult; D001615:beta-Endorphin / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; D007004:Hypoglycemic Agents; D017450:Receptors, Opioid, mu; D001615:beta-Endorphin; D008687:Metformin; C017114:carfentanil; D005283:Fentanyl