title: Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer.
abstract: BACKGROUND
  This study investigates the association between polymorphism in the E-cadherin/CDH1 promoter region and the risk and progression of oral cancer.
  
  
  METHODS
  Genetic polymorphisms of CDH1-160 and -347 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 347 noncancer controls and in 251 patients with oral cancer.
  
  
  RESULTS
  The statistical analysis showed that subjects with at least 1 varied GA allele of CDH1-347 polymorphic genotypes or combinations of the CDH1-160 CA/-347 GGA, CDH1-160 CC/-347 GGA, or CDH1-160 CC/-347 GAGA genotypes had a significantly higher risk, whereas subjects with CDH1-160 C/A or A/A had a significantly lower risk of developing oral cancer than those with wild-type genotypes. Furthermore, elderly patients with the CDH1-347 G/GA or GA/GA genotype were associated with a higher incidence in lymph node metastasis than were those with the G/G genotype.
  
  
  CONCLUSIONS
  These results suggest that CDH1-347 polymorphisms are associated with increased risks of oral cancer, and may be a predictive factor for tumor lymph node metastasis.
authors.affiliation: Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Ming-Hsien
authors.initials: MH
authors.lastname: Chien
authors.forename: Lin Shih-Shen
authors.initials: LS
authors.lastname: Chou
authors.forename: Tsung-Te
authors.initials: TT
authors.lastname: Chung
authors.forename: Chien-Huang
authors.initials: CH
authors.lastname: Lin
authors.forename: Ming-Yung
authors.initials: MY
authors.lastname: Chou
authors.forename: Meng-Shih
authors.initials: MS
authors.lastname: Weng
authors.forename: Shun-Fa
authors.initials: SF
authors.lastname: Yang
authors.forename: Mu-Kuan
authors.initials: MK
authors.lastname: Chen
mesh_terms: D000328:Adult; D054458:Amplified Fragment Length Polymorphism Analysis; D015703:Antigens, CD; D044466:Asian People / Q000235:genetics; D015820:Cadherins / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013624:Taiwan
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins