title: Multidrug-resistant pneumococci (serotype 8) causing invasive disease in HIV+ patients.
abstract: From July 2007 to June 2009, all pneumococci causing invasive pneumococcal disease in our hospital were serotyped. Antimicrobial susceptibility was determined by microdilution. Molecular typing was performed by pulsed-field gel electrophoresis and by multilocus sequence typing. Among 251 invasive pneumococci, serotype 8 was the most frequent (13.5%). All serotype 8 strains were susceptible to penicillin; however, 61.8% (21/34) were co-resistant to erythromycin, levofloxacin and tetracycline and identical to the Sweden(15A) -ST63 clone. Serotype 8 was significantly more frequent among human immunodeficiency virus (HIV)-infected patients (36.5%). The high prevalence of this non-conjugate vaccine multiresistant serotype 8 is a cause for concern mainly in HIV-infected patients.
authors.affiliation: Unidad de Microbiología Clínica, Laboratorio Regional de Salud Pública de Comunidad de Madrid, Madrid, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Sanz
authors.forename: E
authors.initials: E
authors.lastname: Cercenado
authors.forename: M
authors.initials: M
authors.lastname: Marín
authors.forename: B
authors.initials: B
authors.lastname: Ramos
authors.forename: C
authors.initials: C
authors.lastname: Ardanuy
authors.forename: I
authors.initials: I
authors.lastname: Rodríguez-Avial
authors.forename: E
authors.initials: E
authors.lastname: Bouza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D015995:Prevalence; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents