title: [Using cycloferon in complex therapy of patients with cutaneous vasculitis (clinical and immunological rationale)].
abstract: The immunological status was assessed in a group of patients with superficial and profound cutaneous vasculitis diagnoses. It was established that, in both forms of vasculitis, the same type of immune reactions such as activation of cellular and humoral immunity links took place on the background of leucocytosis and lymphocytosis. The violation of T-helper/T-suppressor (Th/Ts) correlation was accompanied by intense stimulation of the helper lymphocyte subpopulation in both forms of vasculitis. In addition, some differences were observed in pathogenesis of the two forms of vasculitis, which were manifested by (i) a marked increase in the level of Ts cells in patients with superficial and a decrease in this level in patients with profound cutaneous vasculitis. In cases of a more serious profound form of vasculitis, it was found that a more intense stimulation of the humoral and fagocyte links of immune regulation took place. The inclusion of cycloferon into the complex therapy led to expressed immunomodulation effect, increase in the clinical therapeutic effect, reduction of the terms of hospitalization, and prolongation of the periods of disease remission.
authors.forename: L A
authors.initials: LA
authors.lastname: Novikova
authors.forename: O B
authors.initials: OB
authors.lastname: Dem'ianova
mesh_terms: D000166:Acridines / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D012720:Severity of Illness Index; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D055815:Young Adult
chemical_list: D000166:Acridines; D007155:Immunologic Factors; C026430:10-carboxymethyl-9-acridanone