title: Severity of obstructive sleep apnea syndrome and high-sensitivity C-reactive protein reduced after relocation pharyngoplasty.
abstract: OBJECTIVE
  To report improvement of obstructive sleep apnea syndrome (OSAS) and changes of high-sensitivity C-reactive protein (hs-CRP) concentrations after relocation pharyngoplasty (RP), a high variant of uvulopalatopharyngoplasty.
  
  
  METHODS
  Prospective comparative study.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Thirty consecutive OSAS patients without a preexisting diagnosis of cardiovascular disease who underwent RP were assessed for body mass index (BMI), Epworth Sleepiness Scale (ESS), sleep apnea-hypopnea index (AHI), and serum levels of hs-CRP at baseline and 6 months postoperatively.
  
  
  RESULTS
  Of the subjects, the mean values of age, BMI, ESS, AHI, and hs-CRP were 39.5 ± 7.0 years, 27.5 ± 4.5 kg/m(2), 10.8 ± 4.2, 46.2 ± 22.9 events/hour, and 2.06 ± 1.78 mg/L, respectively. After 6 months postoperatively, RP reduced the ESS (Δ = -4.3 ± 4.5, P < .001) and AHI (Δ = -28.3 ± 21.1, P < .001) and levels of hs-CRP (Δ = -0.67 ± 1.36, P = .012) significantly, whereas BMI measurements were indifferent (Δ = -0.42 ± 1.28, P = .073). Moreover, the changes of AHI and hs-CRP were particularly remarkable in patients with very severe OSAS (AHI ≥60).
  
  
  CONCLUSIONS
  Although many OSAS patients remain in the mild-moderate category, equivalent improvements in excessive daytime sleepiness and reductions of hs-CRP concentrations indicate that reduction of AHI is not all that matters after RP.
authors.affiliation: Department of Otolaryngology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Li-Ang
authors.initials: LA
authors.lastname: Lee
authors.forename: Chung-Guei
authors.initials: CG
authors.lastname: Huang
authors.forename: Ning-Hung
authors.initials: NH
authors.lastname: Chen
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Wang
authors.forename: Tuan-Jen
authors.initials: TJ
authors.lastname: Fang
authors.forename: Hsueh-Yu
authors.initials: HY
authors.lastname: Li
mesh_terms: D000258:Adenovirus Infections, Human; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010614:Pharynx / Q000601:surgery*; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000601:surgery*
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein