title: Effects of diphenyl diselenide on lipid profile and hepatic oxidative stress parameters in ovariectomized female rats.
abstract: OBJECTIVE
  Ovarian hormone decline after menopause is linked to many pathophysiological reactions. Female rats submitted to ovariectomy are employed as a model of post-menopausal condition. This study investigated the effects of diphenyl diselenide (PhSe)(2) on body weight gain, intra-abdominal fat deposition, plasma lipid profile and hepatic oxidative stress in ovariectomized rats.
  
  
  METHODS
  Female adult Wistar rats were ovariectomized (OVX rats) or sham-operated and divided into four groups: (i) sham-operated, (ii) (PhSe)(2), (iii) OVX and (iv) OVX + (PhSe)(2). (PhSe)(2) (5 mg/kg; 5 ml/kg, p.o.) was administered once a day for 30 days to groups (ii) and (iv). After that, rats were anaesthetized for blood sample gathering and submitted to euthanasia.
  
  
  RESULTS
  (PhSe)(2) (5 mg/kg) was effective in preventing the rise in body weight gain and intra-abdominal fat deposition induced in OVX rats. Although (PhSe)(2) was not effective in avoiding the increase in plasma total cholesterol and non-HDL levels induced in OVX rats, (PhSe)(2) reduced plasma triglycerides and augmented HDL levels in OVX rats. (PhSe)(2) also increased hepatic ascorbic acid levels, reduced glutathione content, glutathione S-transferase activity and restored catalase activity in liver of OVX rats.
  
  
  CONCLUSIONS
  These findings suggest that (PhSe)(2) could be a promising alternative to minimize menopause related symptoms.
authors.affiliation: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Juliana Trevisan
authors.initials: JT
authors.lastname: da Rocha
authors.forename: Simone
authors.initials: S
authors.lastname: Pinton
authors.forename: Alexandre
authors.initials: A
authors.lastname: Mazzanti
authors.forename: Cinthia Melazzo
authors.initials: CM
authors.lastname: Mazzanti
authors.forename: Diego Vilibaldo
authors.initials: DV
authors.lastname: Beckemann
authors.forename: Cristina Wayne
authors.initials: CW
authors.lastname: Nogueira
authors.forename: Gilson
authors.initials: G
authors.lastname: Zeni
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D001555:Benzene Derivatives / Q000494:pharmacology*; D005260:Female; D006728:Hormones / Q000172:deficiency; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D023421:Models, Animal; D009765:Obesity / Q000517:prevention & control; D016566:Organoselenium Compounds / Q000494:pharmacology*; D010052:Ovariectomy; D018384:Oxidative Stress / Q000187:drug effects*; D017698:Postmenopause / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects* / Q000502:physiology
chemical_list: D000975:Antioxidants; D001555:Benzene Derivatives; D006728:Hormones; D008055:Lipids; D016566:Organoselenium Compounds; C061132:diphenyldiselenide; D001205:Ascorbic Acid