title: Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease.
abstract: BACKGROUND
  Paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons.
  
  
  METHODS
  To determine whether genetic variation in the coding region of the paired-like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease.
  
  
  RESULTS
  We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early-onset Parkinson's disease and familial Parkinson's disease.
authors.affiliation: Center for Experimental Medicine and Department of Neurology, the Third Xiangya Hospital, and Department of Physiology, Xiangya Medical School, Central South University, Changsha, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Le
authors.forename: Joseph
authors.initials: J
authors.lastname: Jankovic
authors.forename: Hua-Rong
authors.initials: HR
authors.lastname: Yang
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Xu
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Xie
authors.forename: Zhi
authors.initials: Z
authors.lastname: Song
authors.forename: Hao
authors.initials: H
authors.lastname: Deng
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors; C433629:homeobox protein PITX3