title: Antiviral activity of methylelaiophylin, an alpha-glucosidase inhibitor.
abstract: Methylelaiophylin isolated from Streptomyces melanosporofaciens was selected as an alpha-glucosidase inhibitor with an IC50 value of 10 micrometer. It showed mixedtype inhibition of alpha-glucosidase with a Ki value of 5.94 micrometer. In addition, methylelaiophylin inhibited the intracellular trafficking of hemagglutinin-neuramidase (HN), a glycoprotein of Newcastle disease virus (NDV), in baby hamster kidney (BHK) cells. Methylelaiophylin inhibited the cell surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells.
authors.affiliation: Faculty of Biotechnology, College of Applied Life Science, Jeju National University, Jeju, Korea.
authors.forename: Doseung
authors.initials: D
authors.lastname: Lee
authors.forename: Jin-Kyu
authors.initials: JK
authors.lastname: Woo
authors.forename: Donghern
authors.initials: D
authors.lastname: Kim
authors.forename: Minyoung
authors.initials: M
authors.lastname: Kim
authors.forename: Somi K
authors.initials: SK
authors.lastname: Cho
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Se Pill
authors.initials: SP
authors.lastname: Park
authors.forename: Hyo Yeon
authors.initials: HY
authors.lastname: Lee
authors.forename: Key Zung
authors.initials: KZ
authors.lastname: Riu
authors.forename: Dong-Sun
authors.initials: DS
authors.lastname: Lee
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D006224:Cricetinae; D065089:Glycoside Hydrolase Inhibitors; D015707:HN Protein / Q000378:metabolism; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000302:isolation & purification / Q000494:pharmacology*; D009522:Newcastle disease virus / Q000187:drug effects* / Q000254:growth & development; D021381:Protein Transport / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D065089:Glycoside Hydrolase Inhibitors; D015707:HN Protein; D018942:Macrolides; C033279:elaiophylin