title: Phase transitions in oleic acid and in human breast tissue as studied by Raman spectroscopy and Raman imaging.
abstract: We present the results of differential scanning calorimetry (DSC) and Raman studies in the temperature range of 293-77 K on vibrational properties of the oleic acid and the human breast tissue as a function of temperature. We have found that vibrational properties are very sensitive indicators to specify phases and phase transitions at the molecular level. We have found that water content confined in the cancerous tissue is markedly different from that in the noncancerous tissue. The OH stretching vibrations of water are useful as potential Raman biomarkers to distinguish between the cancerous and the noncancerous human breast tissues. Our results provide experimental evidence on the role of lipid profile and cell hydration as factors of particular significance in differentiation of the noncancerous and cancerous breast tissues.
authors.affiliation: Laboratory of Laser Molecular Spectroscopy, Institute of Applied Radiation Chemistry, Technical University of Lodz, Wroblewskiego 15, 93-590 Lodz, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Brozek-Pluska
authors.forename: Joanna
authors.initials: J
authors.lastname: Jablonska-Gajewicz
authors.forename: Radzislaw
authors.initials: R
authors.lastname: Kordek
authors.forename: Halina
authors.initials: H
authors.lastname: Abramczyk
mesh_terms: D001940:Breast / Q000737:chemistry*; D001943:Breast Neoplasms / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry; D005260:Female; D006801:Humans; D019301:Oleic Acid / Q000737:chemistry*; D044367:Phase Transition; D025341:Principal Component Analysis; D013059:Spectrum Analysis, Raman
chemical_list: D019301:Oleic Acid