title: Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles.
abstract: Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We also showed that rs6929846 of BTN2A1 and rs2569512 of ILF3 were significantly associated with MI in Japanese individuals. In the present study, we examined the relationship between rs6929846 of BTN2A1 or rs2569512 of ILF3 and MI in individuals with low or high serum concentrations of triglycerides, high density lipoprotein (HDL) cholesterol, or low density lipoprotein (LDL) cholesterol, respectively. The study population comprised 5513 unrelated Japanese individuals, including 1537 subjects with MI and 3976 controls. Multivariable logistic regression analyses with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with MI in individuals with low (P=3.1 x 10-5; odds ratio, OR=1.66) or high (P = 1.1 x 10⁻⁶; OR = 2.09) triglycerides; in individuals with low (P = 0.0082; OR = 1.75) or high (P = 2.0 x 10⁻⁹; OR = 1.85) HDL cholesterol; and in individuals with low (P = 3.2 x 10⁻⁷; OR = 1.75) or high (P = 2.8 x 10⁻⁵; OR =2.18) LDL cholesterol. Similar analyses revealed that rs2569512 of ILF3 was significantly associated with MI in individuals with low (P = 0.0066; OR = 1.47) or high (P = 0.0013; OR = 1.88) triglycerides; in individuals with low (P = 0.0059; OR = 1.96) or high (P = 0.0020; OR = 1.51) HDL cholesterol; and in individuals with low (P = 0.0004, OR = 1.62) LDL cholesterol, but not in those with high LDL cholesterol. The results suggest that the relationship between rs6929846 of BTN2A1 or rs2569512 of ILF3 and MI is influenced by the serum concentrations of HDL and LDL cholesterol, respectively. Stratification of subjects according to lipid profiles may thus be useful for the personalized prevention of MI based on genetic information.
authors.affiliation: Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan. yamada@gene.mie-u.ac.jp
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kato
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Oguri
authors.forename: Hideki
authors.initials: H
authors.lastname: Horibe
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kawamiya
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yokoi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Fujimaki
authors.forename: Sachiro
authors.initials: S
authors.lastname: Watanabe
authors.forename: Kei
authors.initials: K
authors.lastname: Satoh
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Masashi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hiroto
authors.initials: H
authors.lastname: Yoshida
authors.forename: Shoji
authors.initials: S
authors.lastname: Shinkai
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D000071797:Butyrophilins; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics*; D050779:Nuclear Factor 90 Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
chemical_list: D000071797:Butyrophilins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C429643:ILF3 protein, human; D008055:Lipids; D008562:Membrane Glycoproteins; D050779:Nuclear Factor 90 Proteins; D014280:Triglycerides