title: Evaluation of safety of lipomer doxycycline hydrochloride (lipomer DH).
abstract: The nanoparticulate formulation of lipomer doxycycline hydrochloride (lipomer DH) has been synthesized for the treatment of Brucellosis to increase efficacy of the drug. The present study was undertaken to determine the intravenous safety of blank lipomer and Lipomer DH in terms of maximum tolerated dose in rats. It was observed that blank lipomer and lipomer DH were safe when administered intravenously at doses 2000 mg/kg Bw and 18 mg/kg bw respectively.
authors.affiliation: National Center for Preclinical Reproductive and Genetic Toxicology, National Institute for Research in Reproductive Health, Parel, Mumbai 400012, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Dhumal
authors.forename: Mahesh
authors.initials: M
authors.lastname: Soni
authors.forename: Padma
authors.initials: P
authors.lastname: Devarajan
authors.forename: Abdul
authors.initials: A
authors.lastname: Samad
authors.forename: Rajiv
authors.initials: R
authors.lastname: Gaikwad
authors.forename: Geeta
authors.initials: G
authors.lastname: Vanage
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D004318:Doxycycline / Q000737:chemistry / Q000633:toxicity*; D007928:Lethal Dose 50; D008081:Liposomes / Q000737:chemistry* / Q000633:toxicity*; D051381:Rats; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: D000900:Anti-Bacterial Agents; D008081:Liposomes; D004318:Doxycycline