title: Design and development of Amphotericin B bearing polycaprolactone microparticles for macrophage targeting.
abstract: Antileishmanial efficacy of Amphotericin B bearing polycaprolactone (PCL) microparticles was investigated. The microparticles were prepared, optimized and subjected to in vitro characterization for shape (spherically structured), particle size (9.83 +/- 1.12 microm), entrapment efficiency (43.54 +/- 3.98%) and in vitro drug release. The study revealed that PCL microparticles bearing Amphotericin B can be effectively used to target leishmanial parasites residing in macrophages.
authors.affiliation: Pharmaceutics Division, Central Drug Research Institute, (Council of Scientific and Industrial Research, India), P.O. Box 173, M. G. Marg, Lucknow 226001, India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Singh
authors.forename: Amit
authors.initials: A
authors.lastname: Gupta
authors.forename: Anil
authors.initials: A
authors.lastname: Jaiswal
authors.forename: Anuradha
authors.initials: A
authors.lastname: Dube
authors.forename: Saurabh
authors.initials: S
authors.lastname: Mishra
authors.forename: Manish K
authors.initials: MK
authors.lastname: Chaurasia
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage* / Q000737:chemistry; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000737:chemistry; D006224:Cricetinae; D004339:Drug Compounding / Q000379:methods; D015195:Drug Design; D007891:Leishmania / Q000187:drug effects* / Q000502:physiology*; D008264:Macrophages / Q000187:drug effects* / Q000469:parasitology*; D008647:Mesocricetus; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D015996:Survival Rate
chemical_list: D000981:Antiprotozoal Agents; D053769:Nanocapsules; D000666:Amphotericin B