title: Chiral Sc-catalyzed asymmetric Michael reactions of thiols with enones in water.
abstract: Asymmetric Michael reactions of thiols with enones were catalyzed by a Sc(OTf)(3)-chiral bipyridine complex at room temperature in water without using any organic solvents, to afford the desired sulfides in high yields with high enantioselectivities.
authors.affiliation: Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ueno
authors.forename: Taku
authors.initials: T
authors.lastname: Kitanosono
authors.forename: Masaru
authors.initials: M
authors.lastname: Sakai
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D012538:Scandium / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000475:Alkenes; D007659:Ketones; D008698:Mesylates; D013438:Sulfhydryl Compounds; C436603:scandium triflate; D014867:Water; D012538:Scandium