title: High eosinophil levels and poor evolution in occupational asthma due to cyanoacrylate exposure.
abstract: We present the case of a 41-year-old woman who developed occupational asthma (OA) due to cyanoacrylate while working in a company that manufactured and marketed plastic products. Specific inhalation challenge confirmed the diagnosis of OA to cyanoacrylate. The patient expressed marked eosinophilic inflammation and marked deterioration of pulmonary function while in persistent contact with the causal agent. The possible etiologic mechanisms implicated in the origin of this type of OA are discussed. Patients diagnosed with this condition are advised to avoid exposure to cyanoacrylates.
authors.affiliation: Pulmonology Department, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
authors.forename: Ruben
authors.initials: R
authors.lastname: Andujar
authors.forename: María-Jesús
authors.initials: MJ
authors.lastname: Cruz
authors.forename: Ana
authors.initials: A
authors.lastname: Villar
authors.forename: Ferran
authors.initials: F
authors.lastname: Morell
authors.forename: Xavier
authors.initials: X
authors.lastname: Muñoz
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004784:Environmental Monitoring; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure; D010969:Plastics / Q000009:adverse effects; D012129:Respiratory Function Tests; D013183:Sputum / Q000166:cytology / Q000378:metabolism
chemical_list: D003487:Cyanoacrylates; D010969:Plastics