title: Lipoprotein(a) levels, apo(a) isoform size, and coronary heart disease risk in the Framingham Offspring Study.
abstract: The aim of this study was to assess the independent contributions of plasma levels of lipoprotein(a) (Lp(a)), Lp(a) cholesterol, and of apo(a) isoform size to prospective coronary heart disease (CHD) risk. Plasma Lp(a) and Lp(a) cholesterol levels, and apo(a) isoform size were measured at examination cycle 5 in subjects participating in the Framingham Offspring Study who were free of CHD. After a mean follow-up of 12.3 years, 98 men and 47 women developed new CHD events. In multivariate analysis, the hazard ratio of CHD was approximately two-fold greater in men in the upper tertile of plasma Lp(a) levels, relative to those in the bottom tertile (P < 0.002). The apo(a) isoform size contributed only modestly to the association between Lp(a) and CHD and was not an independent predictor of CHD. In multivariate analysis, Lp(a) cholesterol was not significantly associated with CHD risk in men. In women, no association between Lp(a) and CHD risk was observed. Elevated plasma Lp(a) levels are a significant and independent predictor of CHD risk in men. The assessment of apo(a) isoform size in this cohort does not add significant information about CHD risk. In addition, the cholesterol content in Lp(a) is not a significant predictor of CHD risk.
authors.affiliation: Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Electronic address: stefania.lamon-fava@tufts.edu.
authors.forename: Stefania
authors.initials: S
authors.lastname: Lamon-Fava
authors.affiliation: Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, WA.
authors.forename: Santica M
authors.initials: SM
authors.lastname: Marcovina
authors.affiliation: Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, WA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Albers
authors.affiliation: Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, WA.
authors.forename: Hal
authors.initials: H
authors.lastname: Kennedy
authors.affiliation: Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
authors.forename: Carl
authors.initials: C
authors.lastname: DeLuca
authors.affiliation: Department of Biostatistics, Boston University, Boston, MA.
authors.forename: Charles C
authors.initials: CC
authors.lastname: White
authors.affiliation: Department of Biostatistics, Boston University, Boston, MA.
authors.forename: L Adrienne
authors.initials: LA
authors.lastname: Cupples
authors.affiliation: Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
authors.forename: Judith R
authors.initials: JR
authors.lastname: McNamara
authors.affiliation: Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
authors.forename: Leo J
authors.initials: LJ
authors.lastname: Seman
authors.affiliation: Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
authors.forename: Vanina
authors.initials: V
authors.lastname: Bongard
authors.affiliation: Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Schaefer
mesh_terms: D001054:Apolipoproteins A / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D020033:Protein Isoforms / Q000097:blood; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D020033:Protein Isoforms; D014280:Triglycerides