title: Calix[4]arenes with two different chemical modifications at the bridges.
abstract: Hexabromocalix[4]arene derivatives (3a and 3b) possessing pairs of dibromomethylene and bromomethylene groups located at distal or proximal positions of the calix scaffold were prepared via photochemical bromination of tetramethoxycalix[4]arene. The dibromomethylene groups undergo hydrolysis to afford calix[4]arenes possessing pairs of carbonyl groups and bromomethylene groups located at distal or proximal bridges (4a and 4b, respectively). The bromomethylene groups of 4 undergo reactions with nucleophiles under S(N)1 conditions to afford a wide array of derivatives possessing two different chemical modifications at the bridges.
authors.affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
authors.forename: Lev
authors.initials: L
authors.lastname: Kuno
authors.forename: Silvio E
authors.initials: SE
authors.lastname: Biali
mesh_terms: D000477:Alkylating Agents / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D047250:Calixarenes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D054879:Halogenation; D008968:Molecular Conformation; D010636:Phenols / Q000737:chemistry*
chemical_list: D000477:Alkylating Agents; D001386:Azides; D002264:Carboxylic Acids; D010636:Phenols; C121325:calix(4)arene; D047250:Calixarenes