title: [Analysis of frequency-domain and window effect for cellular inner and outer membranes subjected to pulsatile electric field].
abstract: Based on multi-layer dielectric model of spherical biological cell, a simulating method of frequency characteristics of inner and outer membranes is presented in this paper. Frequency-domain analysis showed that inner and outer membranes subjected to pulsed electric field exhibit band-pass and low-pass filter characteristics, respectively. A calculating method of the transmembrane potential of inner and outer membranes induced by time-varying electric field was introduced, and the window effect between electric field and transmembrane potential was also analyzed. When the duration is reduced from microsecond to sub-microsecond, and to nanosecond, the target induced was from the outer membrane to inner membrane gradually. At the same time, the field intensity should be increased to induce corresponding bioelectric effects. Window effect provides theoretical guidance to choosing reasonable parameters for application of pulsatile electric field in tumor treatment.
authors.affiliation: State Key Laboratory of Power Transmission Equipment & System Security and New Technology, Chongqing University, Chongqing 400044, China. yaochenguo@cqu.edu.cn
authors.forename: Chenguo
authors.initials: C
authors.lastname: Yao
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Chengxiang
authors.initials: C
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Mi
authors.forename: Caixin
authors.initials: C
authors.lastname: Sun
mesh_terms: D002462:Cell Membrane / Q000502:physiology* / Q000528:radiation effects*; D003198:Computer Simulation; D004574:Electromagnetic Fields; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology* / Q000528:radiation effects*; D008954:Models, Biological