title: Cancer theranostics: the rise of targeted magnetic nanoparticles.
abstract: Interest in utilizing magnetic nanoparticles (MNP) for biomedical applications has increased considerably over the past two decades. This excitement has been driven in large part by the success of MNPs as contrast agents in magnetic resonance imaging. The recent investigative trend with respect to cancer has continued down a diagnostic path, but has also turned toward concurrent therapy, giving rise to the distinction of MNPs as potential "theranostics". Here we review both the key technical principles of MNPs and ongoing advancement toward a cancer theranostic MNP. Recent progress in diagnostics, hyperthermia treatments, and drug delivery are all considered. We conclude by identifying current barriers to clinical translation of MNPs and offer considerations for their future development.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Cole
authors.forename: Victor C
authors.initials: VC
authors.lastname: Yang
authors.forename: Allan E
authors.initials: AE
authors.lastname: David
mesh_terms: D035843:Biomedical Research / Q000639:trends; D004337:Drug Carriers / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D004337:Drug Carriers; D058185:Magnetite Nanoparticles