title: Nanocrystallization of poorly water soluble drugs for parenteral administration.
abstract: Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug. Three different preparations of Amp B were produced by using three different surfactants Tween80, Pluronic F68, Soya Lecithin and assessed for their efficacy and stability. In this study the Amp B nanosuspension formulation, with the smaller particle size, can be effectively produced with the Nanoedge Method. The pharmacokinetic profiles of Amp B when given in the nanosuspension formulation were different compared to the corresponding raw drug.
authors.affiliation: Rayat Institute of Pharmacy, Ropar, Punjab 144533, India.
authors.forename: Foziyah
authors.initials: F
authors.lastname: Zakir
authors.forename: Himanshu
authors.initials: H
authors.lastname: Sharma
authors.forename: Karandeep
authors.initials: K
authors.lastname: Kaur
authors.forename: Basant
authors.initials: B
authors.lastname: Malik
authors.forename: Bhuvaneshwer
authors.initials: B
authors.lastname: Vaidya
authors.forename: Amit K
authors.initials: AK
authors.lastname: Goyal
authors.forename: S P
authors.initials: SP
authors.lastname: Vyas
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D003460:Crystallization / Q000379:methods*; D007263:Infusions, Parenteral; D008657:Metabolic Clearance Rate; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry*; D009928:Organ Specificity; D051381:Rats; D012995:Solubility; D014018:Tissue Distribution; D014867:Water / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D053769:Nanocapsules; D014867:Water; D000666:Amphotericin B