title: On the reducible character of Haldane-Radić enzyme kinetics to conventional and logistic Michaelis-Menten models.
abstract: The conceptual and practical issues regarding the reduction of the Haldane-Radić enzymic mechanism, specific for cholinesterase kinetics, to the consecrated or logistically modified Michaelis-Menten kinetics, specific for some mutant enzymes, are here clarified as due to the limited initial substrate concentration, through detailed initial rate and progress curve analysis, even when other classical conditions for such equivalence are not entirely fulfilled.
authors.affiliation: Laboratory of Computational and Structural Physical Chemistry, Chemistry Department, West University of Timişoara, Pestalozzi Street No.16, Timisoara, RO-300115, Romania. mv_putz@yahoo.com
authors.forename: Mihai V
authors.initials: MV
authors.lastname: Putz
mesh_terms: D000818:Animals; D002802:Cholinesterases / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster; D006868:Hydrolysis; D007700:Kinetics; D016015:Logistic Models; D009154:Mutation
chemical_list: D002802:Cholinesterases