title: High-dose steroid treatment in a patient with Balò disease diagnosed by means of magnetic resonance imaging.
abstract: Balò disease, also called concentric sclerosis, is a rare variant of multiple sclerosis that has been historically characterized as a monophasic, rapidly progressive, often fatal demyelinating disease. The diagnosis of Balò disease is based on the pathognomonic concentric ring pattern seen on magnetic resonance images. The authors describe the case of a 30-year-old woman with Balò disease who was initially treated with an unconventionally high dose of steroids and had a positive long-term clinical outcome with near-complete resolution of her neurologic symptoms. The authors also report MRI findings of concentric lesions before steroid treatment and resolution of the lesions shortly after and several months after steroid treatment. Given the outcome in this patient, we propose using high doses of steroids in the early treatment of patients with Balò disease. However, further studies are needed.
authors.affiliation: Department of Neurology, Ohio State University in Columbus, USA.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Lanciano
authors.forename: Deborah S
authors.initials: DS
authors.lastname: Lyu
authors.forename: Carl
authors.initials: C
authors.lastname: Hoegerl
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006305:Health Status Indicators; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones; D005938:Glucocorticoids; D008775:Methylprednisolone