title: Anti-inflammatory and cytotoxic neoflavonoids and benzofurans from Pterocarpus santalinus.
abstract: Five new benzofurans, pterolinuses A-E (1-5), six new neoflavonoids, pterolinuses F-J (8-13), and five known compounds (6, 7, 14-16) were isolated from an extract of Pterocarpus santalinus heartwood. All new structures were elucidated by spectroscopic methods, and configurations were confirmed by CD spectral data and optical rotation values. The isolates were evaluated for anti-inflammatory and cytotoxic activities. Six compounds (1, 2, 4, 6, 7, and 15) showed significant inhibition in at least one anti-inflammatory assay. Compound 2 showed the best selective effect against superoxide anion generation in human neutrophils with, an IC50 value of 0.19 μg/mL, and was 6.2-fold more potent than the positive control LY294002. Compound 14 showed the highest cytotoxicity against Ca9-22 cancer cells, with an IC50 value of 0.46 μg/mL.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
authors.forename: Shou-Fang
authors.initials: SF
authors.lastname: Wu
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Sheng-Yang
authors.initials: SY
authors.lastname: Wang
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Lee
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Chen
authors.forename: Chin-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002867:Chromones / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007194:India; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009025:Morpholines / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D035721:Pterocarpus / Q000737:chemistry*; D013481:Superoxides / Q000037:antagonists & inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D002867:Chromones; D005419:Flavonoids; D009025:Morpholines; D013481:Superoxides; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one