title: The relationship between body mass index and outcomes in leukemic patients undergoing allogeneic hematopoietic stem cell transplantation.
abstract: Hematopoietic stem cell transplantation (HSCT) is being used increasingly in an attempt to cure many hematological disorders. Obesity has become a world wide phenomenon and is a known risk factor for numerous medical conditions, but its role in transplant outcomes remained controversial. Total of 192 patients with acute leukemia who underwent sibling HLA matched HSCT were analyzed to find the effect of pre-transplant body mass index (BMI) on transplant outcomes such as time to engraftment, infections, graft vs. host disease (GvHD), and overall survival (OS) for the period of three yr (April 2006-March 2009). There was a significant correlation between higher pre-transplant BMI and shorter engraftment time (p = 0.010); but no relation between BMI and GvHD, infection, and OS was found. The results of this study showed that patients with higher BMI may have a shorter engraftment time; but lower, although not significant, survival rate compared to non-obese patients.
authors.affiliation: Faculty of Pharmacy, Department of Clinical Pharmacy, Tehran University of Medical Sciences Hematology-Oncology, Tehran, Iran.
authors.forename: Molouk
authors.initials: M
authors.lastname: Hadjibabaie
authors.forename: Hamed
authors.initials: H
authors.lastname: Tabeefar
authors.forename: Kamran
authors.initials: K
authors.lastname: Alimoghaddam
authors.forename: Masood
authors.initials: M
authors.lastname: Iravani
authors.forename: Kaveh
authors.initials: K
authors.lastname: Eslami
authors.forename: Hooshyar
authors.initials: H
authors.lastname: Honarmand
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Javadi
authors.forename: Farnaz
authors.initials: F
authors.lastname: Khatami
authors.forename: Asieh
authors.initials: A
authors.lastname: Ashouri
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Ghavamzadeh
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000209:etiology* / Q000401:mortality; D019337:Hematologic Neoplasms / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D055815:Young Adult