title: The core human mitochondrial transcription initiation complex: It only takes two to tango.
abstract: We recently demonstrated that the core transcription initiation complex in human mitochondria is a two-component system (POLRMT and h-mtTFB2). Human mtTFA/TFAM, previously proposed to be a requisite initiation complex member, is dispensable for promoter-specific initiation in vitro. We propose that it instead regulates relative promoter activity and/or overall nucleoid transcription and replication potential.
authors.affiliation: Department of Pathology Yale University School of Medicine; New Haven, CT USA.
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Shutt
authors.forename: Megan
authors.initials: M
authors.lastname: Bestwick
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Shadel