title: Asymmetric organocatalytic cascade Michael/hemiketalization/retro-Henry reaction of β,γ-unsaturated ketoesters with α-nitroketones.
abstract: An unprecedented enantioselective organocatalytic Michael/hemiketalization/retro-Henry cascade sequence is described, which catalyzed by a simple bifunctional indane amine-thiourea catalyst. This process provides a new route to the enantioselective synthesis of 5-nitro-pent-2-enoates, a precursor to α-ketolactam.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Yaojun
authors.initials: Y
authors.lastname: Gao
authors.forename: Qiao
authors.initials: Q
authors.lastname: Ren
authors.forename: Woon-Yew
authors.initials: WY
authors.lastname: Siau
authors.forename: Jian
authors.initials: J
authors.lastname: Wang