title: [The analysis of the factors influencing the development of glucocorticoid resistance in the etiopathogenesis of severe bronchial asthma].
abstract: Bronchial asthma is a disease of multi - factored etiology. Current data show that multiple genes may be involved in the pathogenesis of asthma. Corticosteroids (GCS) are the most effective anti-inflammatory therapy for inflammatory disease such as bronchial asthma. There are 2 major types of GCS-resistant asthma to treatment of high doses of inhaled and oral glucocorticoids. Type I GCS-resistant asthma is cytokine-induced or acquired. Type II GCS resistance involves generalized primary cortisol resistance, which affects all tissues and is likely associated with a mutation in the GCR gene or in genes that modulate GCR function. There are clear examples of glucocorticoid gene h-GCR/NR3C1 polymorphisms that can influence responses and sensitivity to glucocorticosteroids. This article may lead to holistic the development analysis of the factors determining the progress of the glucocorticoid resistance in the severe bronchial asthma with special acknowledgement of the influence of polymorphisms of the glucocorticoid receptor gene h-GCR/NR3C1 to formation GCS resistance.
authors.affiliation: Klinika Chorób Wewnetrznych, Astmy i Alergii Uniwersytetu Medycznego w Łodzi, Łódź.
authors.forename: Michał
authors.initials: M
authors.lastname: Panek
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Pietras
authors.forename: Izabela
authors.initials: I
authors.lastname: Kupryś-Lipińska
authors.forename: Paweł
authors.initials: P
authors.lastname: Górski
authors.forename: Piotr
authors.initials: P
authors.lastname: Kuna
authors.forename: Janusz
authors.initials: J
authors.lastname: Szemraj
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D011110:Polymorphism, Genetic; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; C497713:NR3C1 protein, human; D011965:Receptors, Glucocorticoid