title: [Interrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes].
abstract: 95 men aged 45-65, suffering from type 2 diabetes for 0.1-20 years (4.5 +/- 1.4) were examined. Hypoandrogenia (serum testosterone < 10,4 nmol/ml) was noted in 37% of investigated patients. Hyperuricemia (HUA), defined by serum uric acid (UA) content more than 450 pmol/L, was detected in 34% of subjects. In 74% of patients there was a high level of 24h UA urine excretion (UA(u) > 4.43 mmol), suggesting a hyperproduction of UA. Because the level of uricemia is defined by UA production and extretion, we outline two main types of alterations in UA metabolism: normouricemic, hyperuricosuric and hyperuricemic. In normouricemic and hyperuricosuric men UA excretion growth in parallel with the rate of kidney filtration, obesity, glycemia. High urate elimination index (UEI) suggests a decrease of UA reabsorption in kidney. The results allow us to suggest a significance of insulin and testosterone influence on regulation of UA metabolism in aged men with type 2 diabetes and insulin resistance syndrome.
authors.forename: N M
authors.initials: NM
authors.lastname: Hurina
authors.forename: O V
authors.initials: OV
authors.lastname: Korpacheva-Zinych
authors.forename: A A
authors.initials: AA
authors.lastname: Shuprovych
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D013739:Testosterone / Q000097:blood*; D014527:Uric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D007328:Insulin; D014527:Uric Acid; D013739:Testosterone