title: Asymmetric aza-Henry reaction of chiral fluoroalkyl α,β-unsaturated N-tert-butanesulfinyl ketoimines: an efficient approach to enantiopure fluoroalkylated α,β-diamines and α,β-diamino acids.
abstract: The aza-Henry reaction of chiral fluoroalkyl α,β-unsaturated N-tert-butanesulfinyl ketoimines and nitromethane was achieved in the presence of 0.2 equivalent of anhydrous potassium carbonate to give the corresponding adducts diastereoselectively in high yields. Transformations which highlighted the synthetic potential of these aza-Henry adducts were also performed.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhen-Jiang
authors.initials: ZJ
authors.lastname: Liu
authors.forename: Jin-Tao
authors.initials: JT
authors.lastname: Liu
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry*; D054879:Halogenation; D007097:Imines / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000596:Amino Acids; D001372:Aza Compounds; D003959:Diamines; D007097:Imines