title: Effect of zoledronic acid on acro-osteolysis and osteoporosis in a patient with Hajdu-Cheney syndrome.
abstract: Hajdu-Cheney syndrome is a rare, autosomal dominant skeletal dysplasia marked by acro-osteolysis of the distal phalanges and severe osteoporosis. Although there are more than 60 reports published to date, proper treatment and subsequent outcome have been scarce. Herein, we report a progress of anti-resorptive therapy with zoledronic acid, in a woman with Hajdu-Cheney syndrome. Results suggest that anti-resorptive therapy may be important in delaying the progress of osteoporosis and preventing fractures, but not necessarily acro-osteolysis itself.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul 102-752, Korea.
authors.forename: Sena
authors.initials: S
authors.lastname: Hwang
authors.forename: Dong Yoeb
authors.initials: DY
authors.lastname: Shin
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Moon
authors.forename: Eun Jig
authors.initials: EJ
authors.lastname: Lee
authors.forename: Sung-Kil
authors.initials: SK
authors.lastname: Lim
authors.forename: Ok Hwa
authors.initials: OH
authors.lastname: Kim
authors.forename: Yumie
authors.initials: Y
authors.lastname: Rhee
mesh_terms: D030981:Acro-Osteolysis / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D031845:Hajdu-Cheney Syndrome / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy*; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid