title: Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington's Disease.
abstract: Huntington's disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating with symptom severity in patients. Here, we studied the behavior of the BAC HD mouse model using an 24/7 automated system; the results indicate significant lengthening of the circadian period in the mutant mice. These results reinforce previous findings in HD models and symptomatic HD patients, indicating that circadian dysfunction is a core feature of HD.
authors.affiliation: PsychoGenics, Inc.; Princeton University; Barnard College; CHDI Foundation; Barnard College and Columbia University and PsychoGenics/Columbia Univ.
authors.forename: Stephen
authors.initials: S
authors.lastname: Oakeshott
authors.forename: Fuat
authors.initials: F
authors.lastname: Balci
authors.forename: Igor
authors.initials: I
authors.lastname: Filippov
authors.forename: Carol
authors.initials: C
authors.lastname: Murphy
authors.forename: Russell
authors.initials: R
authors.lastname: Port
authors.forename: David
authors.initials: D
authors.lastname: Connor
authors.forename: Ahmad
authors.initials: A
authors.lastname: Paintdakhi
authors.forename: Joseph
authors.initials: J
authors.lastname: Lesauter
authors.forename: Liliana
authors.initials: L
authors.lastname: Menalled
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ramboz
authors.forename: Seung
authors.initials: S
authors.lastname: Kwak
authors.forename: David
authors.initials: D
authors.lastname: Howland
authors.forename: Rae
authors.initials: R
authors.lastname: Silver
authors.forename: Dani
authors.initials: D
authors.lastname: Brunner