title: Aldosterone paradox: differential regulation of ion transport in distal nephron.
abstract: The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions between several players, revealing the complex mechanism behind the aldosterone paradox. We review the mechanisms involved in differential regulation of ion transport that allow the fine tuning of salt and K(+) balance.
authors.affiliation: Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Arroyo
authors.forename: Caroline
authors.initials: C
authors.lastname: Ronzaud
authors.forename: Dagmara
authors.initials: D
authors.lastname: Lagnaz
authors.forename: Olivier
authors.initials: O
authors.lastname: Staub
authors.forename: Gerardo
authors.initials: G
authors.lastname: Gamba
mesh_terms: D000450:Aldosterone / Q000502:physiology*; D000818:Animals; D006801:Humans; D017136:Ion Transport / Q000502:physiology; D007686:Kidney Tubules, Distal / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D012965:Sodium Chloride / Q000378:metabolism
chemical_list: D012965:Sodium Chloride; D000450:Aldosterone; D011188:Potassium