title: Colonic necrosis in a young patient receiving oral kayexalate in sorbitol: case report and literature review.
abstract: Kayexalate (sodium polystyrene sulfonate) is a cation-exchange resin used to treat patients with hyperkalemia. Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal. However, this well-documented complication is often underrecognized both clinically and pathologically. We propose a typical case along with colonoscopic photos and microscopic pictures. Additionally, we also present a review of the literature on this rare drug-induced side effect.
authors.affiliation: Department of Anatomical Pathology, Far Eastern Memorial Hospital, Taipei, Taiwan.
authors.forename: Yueh-Hung
authors.initials: YH
authors.lastname: Chou
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Wang
authors.forename: Min-Shu
authors.initials: MS
authors.lastname: Hsieh
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003106:Colon / Q000473:pathology*; D003113:Colonoscopy; D003460:Crystallization; D006801:Humans; D008297:Male; D009336:Necrosis; D011137:Polystyrenes / Q000009:adverse effects*; D013012:Sorbitol / Q000008:administration & dosage / Q000009:adverse effects*; D013194:Staining and Labeling
chemical_list: D011137:Polystyrenes; D013012:Sorbitol; C003321:polystyrene sulfonic acid