title: [Preeclampsia: oxidative stress, inflammation and endothelial dysfunction].
abstract: Preeclampsia is a systemic syndrome characterized by inflammatory and antiangiogenic states. The pathogenesis of preeclampsia involves deficient trophoblast invasion that is responsible for altered uterine blood flow and placental oxidative stress. The damaged placenta produces higher concentrations of sFlt-1, a soluble receptor for VEGF and PlGF that is released in the maternal circulation and is involved in endothelial dysfunction. Actually, all processes involved in inflammation, endothelial dysfunction and oxidative stress are strongly correlated and act in a synergistic way. Recent data have shown that an increase in serum concentrations of sFlt-1 initiates 5 to 6 weeks before the clinical manifestations of preeclampsia and these alterations correlate with a decrease in serum concentrations of PlGF. Therefore, both sFlt-1 and PlGF have been suggested to be useful for an early-diagnosis of preeclampsia. The knowledge about the role of antiangiogenic factors in the pathogenesis of preeclampsia has raised the possibility of a therapy involving these factors.In this article we revisited the pathogenesis of preeclampsia addressing its antiangiogenic and inflammatory states.In conclusion, we correlated these alterations with the higher risk for cardiovascular diseases presented by these women in future life.
authors.affiliation: Departamento de Obstetrícia, Universidade Federal de São Paulo, São Paulo, Brasil. leminas@ig.com.br
authors.forename: Leandro Gustavo
authors.initials: LG
authors.lastname: de Oliveira
authors.forename: Ananth
authors.initials: A
authors.lastname: Karumanchi
authors.forename: Nelson
authors.initials: N
authors.lastname: Sass
mesh_terms: D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000150:complications*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011256:Pregnancy Outcome