title: Effects of pregnancy and bacterial vaginosis on proinflammatory cytokine and secretory leukocyte protease inhibitor concentrations in vaginal secretions.
abstract: We compared vaginal proinflammatory cytokine and secretory leukocyte protease inhibitor (SLPI) concentrations among pregnant and nonpregnant women according to bacterial vaginosis (BV) status. One-hundred and twenty-two women at 12-20 weeks' gestation and 133 nonpregnant controls had vaginal concentrations of interleukin (IL)-1β, IL-6, IL-8, and SLPI measured by enzyme immunoassay. Multivariable linear regression was used to evaluate factors independently associated with vaginal cytokine and SLPI response. Pregnancy and BV were both independently associated with increased vaginal concentrations of IL-1β and IL-8; pregnant women had increased concentrations of SLPI, while women with BV had decreased SLPI concentrations.
authors.affiliation: Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Balkus
authors.forename: Kathy
authors.initials: K
authors.lastname: Agnew
authors.forename: Richard
authors.initials: R
authors.lastname: Lawler
authors.forename: Caroline
authors.initials: C
authors.lastname: Mitchell
authors.forename: Jane
authors.initials: J
authors.lastname: Hitti
mesh_terms: D000293:Adolescent; D000328:Adult; D002582:Cervix Mucus / Q000737:chemistry*; D005260:Female; D006801:Humans; D007378:Interleukins / Q000032:analysis*; D008875:Middle Aged; D015999:Multivariate Analysis; D011247:Pregnancy / Q000276:immunology* / Q000378:metabolism; D011446:Prospective Studies; D053481:Secretory Leukocyte Peptidase Inhibitor / Q000032:analysis*; D014621:Vagina / Q000737:chemistry*; D016585:Vaginosis, Bacterial / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D007378:Interleukins; D053481:Secretory Leukocyte Peptidase Inhibitor