title: The physiological roles of Sirt1 in skeletal muscle.
abstract: Skeletal muscle aging is associated with increased inflammation and oxidative stress, a decrease in the ability to rebuild muscle after injury and in response to exercise. In this perspective, we discuss the mechanisms regulating Sirt1 activity and expression in skeletal muscles, emphasizing their implications in muscle physiology and the impairment of muscle function with age.
authors.affiliation: Division of Pulmonary, Critical Care and Sleep, Department of Medicine, Baylor College of Medicine, One Baylor Plaza 825E, Houston TX 77030, USA.
authors.forename: Patricia S
authors.initials: PS
authors.lastname: Pardo
authors.forename: Aladin M
authors.initials: AM
authors.lastname: Boriek
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging / Q000502:physiology; D000818:Animals; D051766:Early Growth Response Protein 1 / Q000235:genetics / Q000378:metabolism; D015444:Exercise / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018482:Muscle, Skeletal / Q000473:pathology / Q000502:physiology* / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D056564:Sirtuin 1 / Q000502:physiology*; D013314:Stress, Mechanical
chemical_list: C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; C447939:SIRT1 protein, human; D056564:Sirtuin 1