title: Backbone alignment modeling of the structure-activity relationships of opioid ligands.
abstract: Opioid studies are an important area of modern medicinal chemistry research. In this study we have provided innovative considerations to some long-standing problems in opioid studies, specifically the opioid pharmacophore and the potential binding modes of opioid ligands. Based on a new peptide backbone-alignment concept that we have developed along with this study, we discuss a wide variety of opioid ligands with respect to their structure-activity relationships.
authors.affiliation: ABC Resources , Plainsboro, New Jersey 08536, United States.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Wu
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Hruby
mesh_terms: D000701:Analgesics, Opioid / Q000737:chemistry*; D004743:Enkephalin, Leucine / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D009020:Morphine / Q000737:chemistry*; D018847:Opioid Peptides / Q000737:chemistry*; D011957:Receptors, Opioid / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000701:Analgesics, Opioid; D008024:Ligands; D018847:Opioid Peptides; D011957:Receptors, Opioid; D004743:Enkephalin, Leucine; D009020:Morphine