title: Immunoinflammatory markers and disease activity in systemic lupus erythematosus: something old, something new.
abstract: This study assessed the utility of some novel inflammatory markers compared with traditional laboratory markers in patients with systemic lupus erythematosus (SLE). In a cohort of 43 SLE patients (19 with inactive and 24 with active SLE) and 20 healthy controls, serial measures of soluble vascular cell adhesion molecule (sVCAM-1) were significantly associated with SLE disease activity, scored using the British Isles Lupus Assessment Group index. Inflammatory markers neopterin and soluble intercellular adhesion molecule (sICAM-1) appeared to be clinically useful for isolated assessments of disease activity. Both antibodies to double-stranded DNA (anti-dsDNA) and sVCAM-1 were relatively good markers of disease activity and could help to predict remission or monitorthe therapeutic response in SLE.
authors.affiliation: Department of Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt. elwy.mohamed@yahoo.com
authors.forename: M A
authors.initials: MA
authors.lastname: Elwy
authors.forename: Z A
authors.initials: ZA
authors.lastname: Galal
authors.forename: H E
authors.initials: HE
authors.lastname: Hasan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D015331:Cohort Studies; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D019798:Neopterin / Q000097:blood; D012720:Severity of Illness Index; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D015415:Biomarkers; D003176:Complement C3; D003181:Complement C4; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D019798:Neopterin