title: The role of bacterial biofilm in persistent infections and control strategies.
abstract: Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In hosts, biofilm formation may trigger drug resistance and inflammation, resulting in persistent infections. The clinical aspects of biofilm formation and leading strategies for biofilm inhibitors will be discussed in this mini-review.
authors.affiliation: Key Laboratory of Medical Molecular Virology of Ministry of Education and Ministry of Public Health, Shanghai Medical School of Fudan University, Shanghai 200032, China. lichen_bk@fudan.edu.cn
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Wen
mesh_terms: D018829:Adhesins, Bacterial / Q000187:drug effects / Q000502:physiology*; D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors / Q000235:genetics*; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000494:pharmacology; D001424:Bacterial Infections / Q000382:microbiology* / Q000601:surgery; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D002908:Chronic Disease; D003546:Cysteine Endopeptidases / Q000235:genetics*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000382:microbiology*; D053038:Quorum Sensing / Q000187:drug effects / Q000502:physiology; D014946:Wound Infection / Q000382:microbiology / Q000601:surgery
chemical_list: D018829:Adhesins, Bacterial; D023181:Antimicrobial Cationic Peptides; D001426:Bacterial Proteins; D015853:Cysteine Proteinase Inhibitors; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases