title: Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis.
abstract: BACKGROUND
  Diagnosing polycystic ovary syndrome (PCOS) in adolescence is clinically challenging. The prevalence of clinical, ultrasound and biochemical features of PCOS in a community-based adolescent population using current diagnostic criteria has not previously been described.
  
  
  METHODS
  This was a prospective cohort study with 244 unselected post-menarchal girls, mean age 15.2 years, of whom 91% were Caucasian. Subjects were recruited from a large population-based birth cohort (the Raine cohort). Clinical hyperandrogenism (HA) was quantified using Ferriman-Gallwey scores. In the early follicular phase (Day 2-6), we measured circulating androgens and sex hormone-binding globulin by immunoassay, and ovarian morphology was assessed by transabdominal ultrasound examination. BMI and waist-hip ratio were measured.
  
  
  RESULTS
  Normal ranges for early follicular phase androgens in adolescence were derived for this population. The top 5 and 10% of circulating free testosterone levels were 45.6 and 34.5 pmol/l, respectively. Fifty-one percent of girls reported menstrual irregularity. Clinical HA was uncommon, being observed in only 3.5% of girls. Mean ovarian volume was greater than that reported by others in adult women and 35% of girls had polycystic ovary morphology on transabdominal ultrasound. Taking the upper 5% of free testosterone as HA, 42 girls (18.5%) would have met the Rotterdam criteria for PCOS, 11 girls (5%) the Androgen Excess Society criteria and 7 girls (3.1%) the National Institutes of Health criteria.
  
  
  CONCLUSIONS
  Menstrual irregularity is common in adolescence and does not relate to clinical or biochemical HA. Diagnostic criteria for PCOS which include ovarian volume and morphology may be of limited use in adolescence.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia. martha.hickey@thewomens.org.au
authors.forename: M
authors.initials: M
authors.lastname: Hickey
authors.forename: D A
authors.initials: DA
authors.lastname: Doherty
authors.forename: H
authors.initials: H
authors.lastname: Atkinson
authors.forename: D M
authors.initials: DM
authors.lastname: Sloboda
authors.forename: S
authors.initials: S
authors.lastname: Franks
authors.forename: R J
authors.initials: RJ
authors.lastname: Norman
authors.forename: R
authors.initials: R
authors.lastname: Hart
mesh_terms: D000293:Adolescent; D000728:Androgens / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008599:Menstruation Disturbances / Q000175:diagnosis*; D010053:Ovary / Q000000981:diagnostic imaging; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D014463:Ultrasonography
chemical_list: D000728:Androgens