title: A 57-year-old female with a cerebellar mass.
abstract: A 57-year-old female presented with recurrent episodes of nausea and vomit, as well as instability during walking. The patient had a history of uterine leiomyosarcoma, for which she underwent a hysterectomy and oophorectomy 8 months ago. CT scan revealed a calcified mass that was located in the left cerebellar hemisphere which was resected. Histologically, multiple tissue fragments displayed infiltration of cerebellar tissue by polymorphic spindle-shaped cells. The Ki-67 proliferation index was approximately 20%. The morphological and immunohistochemical data, in association with the past clinical history, were consistent with cerebellar metastasis of uterine leiomyosarcoma. Although adjuvant radiotherapy was introduced, the patient died of cardiopulmonary arrest 6 weeks after the surgical procedure. The present case adds to the body of literature being the second report of uterine leiomyosarcoma metastatic to the cerebellum.
authors.affiliation: Department of Pathology, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Venizelos
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Anagnostou
authors.forename: Thomas
authors.initials: T
authors.lastname: Papathomas
authors.forename: Vasilios
authors.initials: V
authors.lastname: Spandos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Marinopoulos
authors.forename: Parmenion
authors.initials: P
authors.lastname: Tsitsopoulos
authors.forename: Christos
authors.initials: C
authors.lastname: Tsonidis
mesh_terms: D002528:Cerebellar Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D011859:Radiography; D014594:Uterine Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery