title: [Hard palate B cell lymphoma with spontaneous regression].
abstract: BACKGROUND
  Non-Hodgkin lymphomas are common cancers that can develop in the upper aero-digestive tract. We describe a case of a large B-cell palatine lymphoma with spontaneous clinical regression.
  
  
  METHODS
  A 58-year-old female patient presented with a sub-mucosal lesion of the hard palate. CT scan and magnetic resonance imaging revealed a lesion invading the right posterior palatine canal. At the second consultation, 15 days after performing the biopsy, the lesion had disappeared. PET scan proved the absence of lesion. Lymph node biopsy supported the diagnosis of large B-cell lymphoma.
  
  
  CONCLUSIONS
  Large B-cell lymphoma of the hard palate is a rare disease. Only 27 cases have been described in the international literature. The anatomopathological analysis is often difficult to perform. The final diagnosis is often made by immunochemistry. The usual treatment is R-CHOP chemotherapy (cyclophosphamide, adriamycin, vincristine, prednisone combined to rituximab) with a 5-year survival rate at 55%.
authors.affiliation: Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, CHU Saint-Pierre, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Brachet
authors.forename: L
authors.initials: L
authors.lastname: de Leval
authors.forename: L
authors.initials: L
authors.lastname: Deleval
authors.forename: G
authors.initials: G
authors.lastname: Chantrain
authors.forename: I
authors.initials: I
authors.lastname: Loeb
authors.forename: S
authors.initials: S
authors.lastname: Saussez
mesh_terms: D001706:Biopsy; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous / Q000473:pathology*; D010157:Palatal Neoplasms / Q000473:pathology*; D021362:Palate, Hard / Q000473:pathology*; D049268:Positron-Emission Tomography; D013365:Submandibular Gland Neoplasms / Q000473:pathology; D014057:Tomography, X-Ray Computed