title: Selection of HLA-B57-associated Gag A146P mutant by HLA-B∗48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese.
abstract: We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138-147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140-147(GI8) to be the optimal epitope rather than LI10 and that GI8-specific T cells failed to recognize the A146P mutant virus-infected cells. The sequence analysis of Gag146 in 261 chronically HIV-1-infected Japanese showed the accumulation of the A146P mutation in HLA-B∗48:01(+) individuals. These findings together indicate that the A146P mutant is accumulating in Japanese by selection by GI8-specific CTLs.
authors.affiliation: Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Naruto
authors.forename: Hayato
authors.initials: H
authors.lastname: Murakoshi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Chikata
authors.forename: Madoka
authors.initials: M
authors.lastname: Koyanagi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kawashima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Gatanaga
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oka
authors.forename: Masafumi
authors.initials: M
authors.lastname: Takiguchi
mesh_terms: D015331:Cohort Studies; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007564:Japan; D009154:Mutation; D010455:Peptides; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D017423:Sequence Analysis, RNA; D018709:Statistics, Nonparametric; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*
chemical_list: D015235:HLA-B Antigens; C103707:HLA-B57 antigen; D010455:Peptides; D012367:RNA, Viral; D054301:gag Gene Products, Human Immunodeficiency Virus