title: Is antigen specificity the key to efficient adoptive T-cell therapy?
abstract: Adoptive transfer of T cells remains a promising approach in melanoma. Initial clinical trials performed with polyclonal tumor-infiltrating lymphocyte gave limited clinical results. Nonetheless, encouraging results have been reported in adjuvant setting (stage III melanoma), and when tumor-infiltrating lymphocytes were associated with lymphodepleting regimens. Specificity of adoptive cell therapy has been achieved with the infusion of antigen specific cytotoxic T-lymphocyte clones, associated with some clinical responses. Antigen specificity can also be obtained by the allogeneic transfer of high-avidity T-cell receptors into autologous T cells. We propose an alternative strategy based on the selection of antigen-specific T cells with magnetic beads coated with HLA-peptide multimers. Future improvements of adoptive melanoma immunotherapy may be achieved by its association with other therapeutic strategies such as targeted therapy against signaling pathways.
authors.affiliation: Unite Mixte de Recherche Institut National de la Sante et de la Recherche Medicale, Unite 892, Centre de Recherche en Canerologie Nantes-Angers, Nantes, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Labarriere
authors.forename: Amir
authors.initials: A
authors.lastname: Khammari
authors.forename: Francois
authors.initials: F
authors.lastname: Lang
authors.forename: Brigitte
authors.initials: B
authors.lastname: Dreno
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology*; D002986:Clinical Trials as Topic; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D016246:Lymphocytes, Tumor-Infiltrating / Q000166:cytology / Q000276:immunology / Q000637:transplantation*; D008545:Melanoma / Q000276:immunology / Q000628:therapy*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology / Q000628:therapy*; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology / Q000637:transplantation*; D016896:Treatment Outcome
chemical_list: D000951:Antigens, Neoplasm; D011948:Receptors, Antigen, T-Cell