title: Synthesis of some chalcones and pyrazolines carrying morpholinophenyl moiety as potential anti-inflammatory agents.
abstract: Chalcones of 2a-f and their corresponding products, pyrazolines 3a-f, were synthesized and evaluated for their anti-inflammatory activity against carrageenan edema in albino rats at a dose of 10 mg/kg. All the compounds of this series showed promising anti-inflammatory activity. The most active compounds of this series, 2a, 2b, and 2d, were found to be most potent. They showed higher percentage of inhibition of edema than the standard drug indomethacin.
authors.affiliation: Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. omneyafawzy@yahoo.com
authors.forename: Omneya M
authors.initials: OM
authors.lastname: Khalil
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D003500:Cyclization; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy; D008297:Male; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D047188:Chalcones; D009025:Morpholines; D011720:Pyrazoles