title: Dietary, anthropometric, and biochemical determinants of plasma high-density lipoprotein-cholesterol in free-living adults.
abstract: The level of high-density lipoprotein is thought to be critical in inhibiting lesion formation as well as reducing the lipid load of preexisting atherosclerotic lesions. With the aim of determining the main determinants of plasma HDL-cholesterol (HDL-c) in free-living adults, 997 individuals (52.3 ± 10 years, 67% females) were selected for a descriptive cross-sectional study. The used data corresponded to the baseline obtained from participants clinically selected for a lifestyle modification program. Covariables of clinical, anthropometry, food intake, aerobic fitness, and plasma biochemistry were analyzed against plasma HDL-c either as continuous or categorized variables. After adjustments for age, gender, and BMI the excess of abdominal fat along with high carbohydrate-energy intake and altered plasma triglycerides were the stronger predictors of reduced plasma HDL-c. In conclusion lifestyle interventions aiming to normalize abdominal fatness and plasma triglycerides are recommended to restore normal levels of HDL-c in these free-living adults.
authors.affiliation: Department of Public Health, CeMENutri-Centre for Physical and Nutritional Metabolism, Sao Paulo State University (UNESP), District of Rubião Junior s/no, 18618-970 Botucatu, SP, Brazil.
authors.forename: Erick Prado
authors.initials: EP
authors.lastname: de Oliveira
authors.forename: Rodrigo Minoru
authors.initials: RM
authors.lastname: Manda
authors.forename: Gabriel Augusto
authors.initials: GA
authors.lastname: Torezan
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Corrente
authors.forename: Roberto Carlos
authors.initials: RC
authors.lastname: Burini