title: ABCB1 genotype and CSF beta-amyloid in Alzheimer disease.
abstract: The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood-brain barrier, where it mediates the efflux of β-amyloid (Aβ) from the brain. In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of Aβ. No strong evidence for association was found.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA. ruko@uw.edu
authors.forename: R
authors.initials: R
authors.lastname: Kohen
authors.forename: J B
authors.initials: JB
authors.lastname: Shofer
authors.forename: O
authors.initials: O
authors.lastname: Korvatska
authors.forename: E C
authors.initials: EC
authors.lastname: Petrie
authors.forename: L Y
authors.initials: LY
authors.lastname: Wang
authors.forename: G D
authors.initials: GD
authors.lastname: Schellenberg
authors.forename: E R
authors.initials: ER
authors.lastname: Peskind
authors.forename: C W
authors.initials: CW
authors.lastname: Wilkinson
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000235:genetics*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D016229:Amyloid beta-Peptides