title: Lymphangiogenesis and hemangiogenesis: potential targets for therapy.
abstract: This review updates historical background from century-old observations on embryonic lymphatic system development through current understanding of the molecular basis of lymphvasculogenesis/lymphangiogenesis ("molecular lymphology"), highlighting similarities and differences with analogous blood vasculature processes. Topics covered include molecular mechanisms in lymphatic development, structural adaptations of the lymphatic vasculature to particulate and cellular transport and trafficking, lymphogenous route of clinical cancer spread, preservation of delineated lymphatic pathways during cancer operations, and anti-lymphangiogenesis in cancer therapy.
authors.affiliation: Department of Surgery, University of Arizona College of Medicine, Tucson, Arizona 85724-5200, USA. grace@surgery.arizona.edu
authors.forename: Marlys H
authors.initials: MH
authors.lastname: Witte
authors.forename: Michael T
authors.initials: MT
authors.lastname: Dellinger
authors.forename: Donald M
authors.initials: DM
authors.lastname: McDonald
authors.forename: S David
authors.initials: SD
authors.lastname: Nathanson
authors.forename: Francesco M
authors.initials: FM
authors.lastname: Boccardo
authors.forename: Corradino C C
authors.initials: CC
authors.lastname: Campisi
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Sleeman
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Gershenwald
mesh_terms: D020533:Angiogenesis Inhibitors; D006801:Humans; D042583:Lymphangiogenesis / Q000502:physiology; D008207:Lymphatic Metastasis / Q000503:physiopathology; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic
chemical_list: D020533:Angiogenesis Inhibitors