title: Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability.
abstract: Secondary malignancies (SMs) in Hodgkin lymphoma (HL) are thought to be related to exposure to alkalating agents, topoisomerase II inhibitors and ionizing radiation, and tend to occur a decade after initial therapy. We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. The MFH and post-surgical reactive tissues exhibited multiple clonal abnormalities. In addition, PHA-stimulated peripheral blood lymphocytes showed increased frequency of non-clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed.
authors.affiliation: Division of Pediatric Hematology Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan.
authors.forename: Shanmuganathan
authors.initials: S
authors.lastname: Chandrakasan
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Ye
authors.forename: Meera
authors.initials: M
authors.lastname: Chitlur
authors.forename: Anwar N
authors.initials: AN
authors.lastname: Mohamed
authors.forename: Raja
authors.initials: R
authors.lastname: Rabah
authors.forename: Andre
authors.initials: A
authors.lastname: Konski
authors.forename: Henry H Q
authors.initials: HH
authors.lastname: Heng
authors.forename: Süreyya
authors.initials: S
authors.lastname: Savaşan
mesh_terms: D000293:Adolescent; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D042822:Genomic Instability; D051677:Histiocytoma, Malignant Fibrous / Q000209:etiology*; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology*; D049268:Positron-Emission Tomography; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014182:Transplantation, Autologous; D016896:Treatment Outcome