title: Ivermectin-related adverse clinical events in patients treated for Mansonella ozzardi infections.
abstract: We report the occurrence of serious reactions after treatment with oral ivermectin in two patients with Mansonella ozzardi infections. Both had systemic and respiratory symptoms and recovered without sequelae. Follow-up revealed clearance of microfilaremia in both cases, with relapse in one of them. These reactions are well described in the treatment of other filarial infections, but have not yet been reported in the treatment of M. ozzardi. We are now reporting the first such known reactions with this helminthiasis.
authors.affiliation: Instituto de Investigaciones en Enfermedades Tropicales, Sede regional Orán, Universidad Nacional de Salta, San Ramón de la Nueva Orán, Argentina. alekrol@hotmail.com
authors.forename: Alejandro J
authors.initials: AJ
authors.lastname: Krolewiecki
authors.forename: Silvana P
authors.initials: SP
authors.lastname: Cajal
authors.forename: Carlos
authors.initials: C
authors.lastname: Villalpando
authors.forename: José F
authors.initials: JF
authors.lastname: Gil
mesh_terms: D000368:Aged; D000818:Animals; D001118:Argentina; D023341:Chills / Q000139:chemically induced*; D003131:Combined Modality Therapy; D004417:Dyspnea / Q000139:chemically induced*; D005260:Female; D005334:Fever / Q000139:chemically induced*; D005369:Filaricides / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007559:Ivermectin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008366:Mansonella / Q000187:drug effects; D008368:Mansonelliasis / Q000188:drug therapy* / Q000469:parasitology; D008842:Microfilariae / Q000187:drug effects; D018512:Parasitemia / Q000188:drug therapy* / Q000469:parasitology; D008517:Phytotherapy; D012008:Recurrence
chemical_list: D005369:Filaricides; D007559:Ivermectin