title: [Acute cardiac failure due to itraconazole].
abstract: BACKGROUND
  Itraconazole is an azole derivative used for the treatment of aspergillosis. Cardiac failure is a rare complication of treatment. Most cases occur in patients with cardiovascular risk factors, or taking multiple medications, and a causal relationship is not well-established.
  
  
  METHODS
  We report the case of a patient, without cardiovascular risk factors, presenting with cardiac failure during treatment with itraconazole. Pre-treatment stress testing and echocardiography were normal. Resolution was complete without sequelae.
  
  
  CONCLUSIONS
  Cardiac failure can occur in association with itraconazole despite normal cardiological investigations before treatment.
authors.affiliation: Service de pneumologie, hôpital d'Instruction des Armées Clermont-Tonnerre, rue du Colonel-Fonferrier, Brest, France. nicolas.paleiron@free.fr
authors.forename: N
authors.initials: N
authors.lastname: Paleiron
authors.forename: N
authors.initials: N
authors.lastname: Bizien
authors.forename: U
authors.initials: U
authors.lastname: Vinsonneau
authors.forename: M
authors.initials: M
authors.lastname: Andre
authors.forename: F
authors.initials: F
authors.lastname: Grassin
mesh_terms: D000208:Acute Disease; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001228:Aspergillosis / Q000188:drug therapy*; D004562:Electrocardiography; D006333:Heart Failure / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole