title: Spatial expression of the genome: the signal hypothesis at forty.
abstract: The signal hypothesis, formulated by Günter Blobel and David Sabatini in 1971, and elaborated by Blobel and his colleagues between 1975 and 1980, fundamentally expanded our view of cells by introducing the concept of topogenic signals. Cells were no longer just morphological entities with compartmentalized biochemical functions; they were now active participants in the creation and perpetuation of their own form and identity, the decoders of linear genetic information into three dimensions.
authors.affiliation: Department of Surgery, The University of Chicago, 5841 South Maryland Avenue, MC 5032, SBRI J557, Chicago, Illinois 60637-1470, USA. kmatlin@uchicago.edu.
authors.forename: Karl S
authors.initials: KS
authors.lastname: Matlin
mesh_terms: D004721:Endoplasmic Reticulum / Q000378:metabolism*; D008957:Models, Genetic; D014176:Protein Biosynthesis / Q000235:genetics*; D021382:Protein Sorting Signals / Q000235:genetics*; D012270:Ribosomes / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D021382:Protein Sorting Signals