title: Altered brain dynamics during voluntary movement in individuals with Down syndrome.
abstract: Individuals with Down syndrome have well known cognitive and sensorimotor impairments, however, the underlying neural processes are poorly understood. The objective of this study was to investigate the underlying spatial localization and functional connectivity during voluntary movements of the right index finger. Adults with Down syndrome and healthy control adults participated in this study. Cortical responses were recorded with a 151-channel magnetoencephalographic system. In the Down syndrome group, we observed two distinct patterns of brain activation, an ipsilateral pattern and a contralateral pattern in the low-frequency band. The two distinct patterns of neural activation and the altered underlying network dynamics have not been reported previously, and may reflect differences in sensorimotor organization.
authors.affiliation: Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada. naznin.virji-babul@ubc.ca
authors.forename: Naznin
authors.initials: N
authors.lastname: Virji-Babul
authors.forename: Alexander
authors.initials: A
authors.lastname: Moiseev
authors.forename: Nadya
authors.initials: N
authors.lastname: Moiseeva
authors.forename: Wenqi
authors.initials: W
authors.lastname: Sun
authors.forename: Urs
authors.initials: U
authors.lastname: Ribary
authors.forename: Ira
authors.initials: I
authors.lastname: Lott
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D004314:Down Syndrome / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology*; D009483:Neuropsychological Tests / Q000592:standards; D011597:Psychomotor Performance / Q000502:physiology; D014836:Volition / Q000502:physiology*; D055815:Young Adult