title: Crosslinking of trimethylene carbonate and D, L-lactide (co-) polymers by gamma irradiation in the presence of pentaerythritol triacrylate.
abstract: High-molecular-weight (co)polymers of trimethylene carbonate and D,L-lactide are efficiently crosslinked using PETA during gamma irradiation. Form-stable networks with gel contents of 86 ± 5 to 96 ± 1 are obtained from non-crystalline (co)polymers. Glass transition temperatures and elastic moduli of the networks can be varied by adjusting the copolymer composition. The PETA-containing (co)polymer networks are not cytotoxic. Upon incubation in macrophage cultures for 14 d, all (co)polymer films and PETA-containing network films erode to varying extents, showing that these materials can be degraded by cell-mediated erosion processes. This method is very useful for the facile preparation of TMC- and DLLA-containing form-stable networks from high-molecular-weight polymers.
authors.affiliation: Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
authors.forename: Erhan
authors.initials: E
authors.lastname: Bat
authors.forename: Theo G
authors.initials: TG
authors.lastname: van Kooten
authors.forename: Jan
authors.initials: J
authors.lastname: Feijen
authors.forename: Dirk W
authors.initials: DW
authors.lastname: Grijpma
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004146:Dioxanes / Q000737:chemistry*; D005720:Gamma Rays; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D011409:Propylene Glycols / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D000179:Acrylates; D001672:Biocompatible Materials; D004146:Dioxanes; D011108:Polymers; D011409:Propylene Glycols; C443643:trimethylene carbonate; C091880:dilactide; C027992:pentaerythrityl triacrylate