title: Synthesis and characterization of novel biodegradable folate conjugated polyurethanes.
abstract: In order to obtain targeting polyurethane micelle drug carriers, a series of biodegradable folate conjugated polyurethanes (FPUs) were synthesized using poly(ethylene glycol) (PEG) and poly(ε-caprolactone) (PCL) as soft segments, L-lysine ethyl ester diisocyanate (LDI) and 1,3-propanediol (PDO) as hard segments, and folic acid-ethylenediamine conjugate (FA-EDA) as an end-capping reagent. The resultant FPUs were fully characterized by (1)H NMR, Fourier-transform infrared (FTIR) spectroscopy, ultraviolet spectrophotometry (UV), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC). These polymers can self-assemble into micelles in aqueous solutions confirmed by dynamic light scattering (DLS), pyrene fluorescence probe techniques, and transmission electron microscopy (TEM). The results indicated that the bulk structures and micellar properties of the prepared polyurethanes could be controlled by varying the PEG content in the soft segments. The present work provides a facile approach to prepare amphiphilic multiblock copolymers with tumor targeting moiety, which is a good candidate as biodegradable carriers for active intracellular drug delivery.
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
authors.forename: Lunquan
authors.initials: L
authors.lastname: Yu
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhou
authors.forename: Mingming
authors.initials: M
authors.lastname: Ding
authors.forename: Jiehua
authors.initials: J
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Tan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.forename: Xueling
authors.initials: X
authors.lastname: He
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D004337:Drug Carriers / Q000138:chemical synthesis*; D005492:Folic Acid / Q000737:chemistry*; D008823:Micelles; D015394:Molecular Structure; D011092:Polyethylene Glycols; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D011140:Polyurethanes; D011092:Polyethylene Glycols; D005492:Folic Acid