title: Superior long-term outcomes after surgery in child-pugh class a patients with single small hepatocellular carcinoma compared to radiofrequency ablation.
abstract: OBJECTIVE
  There are insufficient data comparing long-term prognoses after radiofrequency ablation (RFA) and surgery.
  
  
  METHODS
  We compared the baseline characteristics and survival rates of patients (single, ≤3 cm, and Child-Pugh class A) treated surgically (n = 215) and with RFA (n = 255) from January 2000 to December 2007 at our institution.
  
  
  RESULTS
  The surgery group was characterized by younger age, higher prevalence of HBsAg, less cirrhosis, and an increased chance of Child-Pugh score of 5 and CLIP score of 1, compared to the RFA group. During the median follow-up period of 42 months (range 1-109), the 3-, 5- and 7-year overall survival rates in the surgery group were 98, 94, and 94%, respectively, which were significantly higher than those in the RFA group (92, 87, and 76%, respectively, P = 0.002). The 3- and 5-year recurrence-free survival rates were 72 and 66%, respectively, in the surgery group, which were significantly higher than those in the RFA group (34 and 24%, respectively, P < 0.001). The superiority of the survival rates in the surgery group persisted in most patients throughout the subgroup analysis, based on the Child-Pugh score and CLIP score. Multivariate analysis showed that age and surgery as a procedure type were the significant predictive factors for both overall survival [HR = 1.04 (CI 1.001-1.08), P = 0.047 for age; HR = 2.97 (CI 1.19-7.45), P = 0.02 for surgery] and recurrence-free survival [HR = 1.02 (CI 1.01-1.04), P = 0.01 for age; HR = 2.44 (CI 1.76-3.37), P < 0.001 for surgery].
  
  
  CONCLUSIONS
  The long-term outcome after surgery for Child-Pugh class A and single small HCC is superior to that after RFA.
authors.affiliation: Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Won Kyoung
authors.initials: WK
authors.lastname: Yun
authors.forename: Moon Seok
authors.initials: MS
authors.lastname: Choi
authors.forename: Dongil
authors.initials: D
authors.lastname: Choi
authors.forename: Hyun-Chul
authors.initials: HC
authors.lastname: Rhim
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Joh
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Jang
authors.forename: Joon Hyeok
authors.initials: JH
authors.lastname: Lee
authors.forename: Kwang Cheol
authors.initials: KC
authors.lastname: Koh
authors.forename: Seung Woon
authors.initials: SW
authors.lastname: Paik
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Yoo