title: Ovarian squamous cell carcinoma which metastasized 8 years after cervical conization for early microinvasive cervical cancer: a case report.
abstract: Squamous cell cervical carcinoma that metastasized to the ovary is common in patients with bulky tumors or locally advanced disease; however, ovarian squamous cell carcinoma that metastasized after cervical conization surgery for early microinvasive uterine cervical carcinoma is very rare. We present a case of ovarian squamous cell carcinoma that metastasized 8 years after cervical conization surgery for early microinvasive cervical carcinoma. She had no sign of recurrence in the uterine cervix. We detected human papillomavirus type 16 DNA in both cervical tissue and ovarian tissue, suggesting that ovarian squamous cell carcinoma is derived from microinvasive cervical cancer. Although there are very few cases of early microinvasive squamous cell carcinoma that metastasized to the ovary with delayed recurrence, we should pay attention strictly not only to the cervical condition but also to the ovarian condition on regular post-operative follow-up.
authors.affiliation: Department of Obstetrics and Gynecology, University of Toyama, 2630, Sugitani, Toyama-shi, Toyama 930-0194, Japan. hidaka@med.u-toyama.ac.jp
authors.forename: Takao
authors.initials: T
authors.lastname: Hidaka
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Nakashima
authors.forename: Toru
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nomoto
authors.forename: Shin
authors.initials: S
authors.lastname: Ishizawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Tsuneyama
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Takano
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000556:secondary* / Q000601:surgery* / Q000821:virology; D017024:Chemotherapy, Adjuvant; D019092:Conization; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000235:genetics / Q000302:isolation & purification*; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery* / Q000821:virology; D017239:Paclitaxel / Q000008:administration & dosage; D010166:Palliative Care / Q000379:methods*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000601:surgery* / Q000821:virology; D018714:Radiotherapy, Adjuvant; D012086:Reoperation; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery* / Q000821:virology; D057832:Watchful Waiting
chemical_list: D014408:Biomarkers, Tumor; C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004279:DNA, Viral; D009363:Neoplasm Proteins; D016190:Carboplatin; D017239:Paclitaxel