title: Elevated risk of papillary thyroid cancer in Korean patients with Hashimoto's thyroiditis.
abstract: Hashimoto's thyroiditis (HT) and higher levels of thyroid-stimulating hormone (TSH) have been proposed as risk factors for papillary thyroid cancer (PTC), but this issue is still being debated. The purpose of this study was whether HT was related to the risk of PTC over TSH.
  
  
  
  We enrolled 1329 patients (1028 with PTC, 52 with follicular thyroid cancer, and 249 with benign disease) of 1490 patients who underwent thyroidectomy.
  
  
  
  The TSH concentration was not different among patients with PTC or benign disease. Our study showed that men (odds ratio [OR] = 1.54; p = .049) and the presence of HT (OR = 2.96; p <.001) increased the risk of PTC. Moreover, HT was associated with multifocal cancer (p = .005) and smaller tumor size (p = .031), but it did not influence the extrathyroidal invasion or nodal metastasis.
  
  
  
  Clinicians who deal with thyroid nodules should pay particular attention to HT because it is a stronger predictor for PTC than other risk factors.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Kim
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Park
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Kim
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Park
authors.forename: Do Joong
authors.initials: DJ
authors.lastname: Park
authors.forename: Soon-Hyun
authors.initials: SH
authors.lastname: Ahn
authors.forename: Do Joon
authors.initials: DJ
authors.lastname: Park
authors.forename: Hak C
authors.initials: HC
authors.lastname: Jang
authors.forename: Bo Youn
authors.initials: BY
authors.lastname: Cho
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D001323:Autoantibodies / Q000097:blood; D002291:Carcinoma, Papillary / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D050031:Hashimoto Disease / Q000453:epidemiology*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012737:Sex Factors; D013954:Thyroglobulin / Q000276:immunology; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D016606:Thyroid Nodule / Q000453:epidemiology / Q000601:surgery; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D001323:Autoantibodies; D013972:Thyrotropin; D013954:Thyroglobulin; D007453:Iodide Peroxidase; D013974:Thyroxine