title: The Ninth Annual American Association of cancer research international conference on frontiers in cancer prevention research.
abstract: The Ninth Annual AACR Frontiers in Cancer PREVENTION Research conference was held in Philadelphia in November 7-10, 2010. Its thematic focus was "
  
  
  CONCLUSIONS
  From Basic Science to Public Health Benefit." Telomere plasticity, the microenvironment, inflammation, transformation to the metastatic phenotype, and pathways to obesity were highlighted as important elements of carcinogenesis amenable to intervention. The integration of information from novel technologies related to physical biology, molecular and genetic profiles, and imaging along with behavioral and clinical parameters have advanced risk stratification and early detection. Cancer prevention represents a powerful testing ground for the development of individually tailored intervention and for increasing the efficiency of drug discovery. Advances in clinical trials relate to more efficient design strategies, have shown first-in-human targeting capabilities, and have developed powerful strategies to overcome accrual barriers. Tailored intervention strategies now show high efficacy on large cohorts across several cancer types. These successes are expected to increase.
authors.affiliation: Department of Medicine, the Robert H LurieCancer Center of Northwestern University, Chicago, Illinois, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Sophia S
authors.initials: SS
authors.lastname: Wang
authors.forename: Megan A
authors.initials: MA
authors.lastname: Healey
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Faupel-Badger
authors.forename: Jason A
authors.initials: JA
authors.lastname: Wilken
authors.forename: Tracy
authors.initials: T
authors.lastname: Battaglia
authors.forename: Eva
authors.initials: E
authors.lastname: Szabo
authors.forename: Jenny T
authors.initials: JT
authors.lastname: Mao
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Bergan
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D008495:Medical Oncology / Q000639:trends*; D009369:Neoplasms / Q000517:prevention & control*; D012106:Research