title: [Diagnostic norms of RAPID neuropsychological battery tests for subjects aged 60 to 89 years with Alzheimer's disease].
abstract: BACKGROUND
  The aim of this study was to propose diagnostic norms for the rapid neuropsychological battery, in the detection of cognitive impairment due to Alzheimer's disease.
  
  
  METHODS
  Three hundred and fifty-two control subjects (mean MMSE : 27.3 ± 2.5) and 676 patients with Alzheimer's disease (mean MMSE : 22.9 ± 2.6) at a mild stage (CDR = 1) were selected according to age (60-69, 70-79 and 80-89 years) and educational level (French primary Education Certificate or lower versus Certificate of Professional Aptitude or the School Leaving Certificate versus the Baccalaureate or higher). Age and education-adjusted cut-off scores were calculated using Receiver Operating Characteristic curves so as to determine the discriminative ability (sensitivity, specificity) of each test from the RAPID neuropsychological battery. Cut-off scores with a specificity set at least at 90% were also proposed.
  
  
  RESULTS
  The Free and Cued Recall Test exhibited good sensitivity (from 87% to 100% for free recall and from 85% to 98% for total recall) and specificity (from 85% to 96% for free recall and from 86% to 100% for total recall). For the other tests, sensitivities and specificities were lower.
  
  
  CONCLUSIONS
  The use of these two types of cut-off scores should help the clinician in the diagnosis of Alzheimer's disease by limiting the risk of false positives and false negatives. The choice of the cut-off scores will depend on the patient's individual clinical context.
authors.affiliation: Service de Neurologie,Centre Mémoire de Ressources et de Recherche de Franche-Comté, CHU Jean-Minjoz, 3 Boulevard Alexander-Fleming, 25000 Besançon, France.
authors.forename: G
authors.initials: G
authors.lastname: Sylvestre
authors.forename: G
authors.initials: G
authors.lastname: Chopard
authors.forename: G
authors.initials: G
authors.lastname: Tio
authors.forename: E
authors.initials: E
authors.lastname: Magnin
authors.forename: L
authors.initials: L
authors.lastname: Rumbach
authors.forename: P
authors.initials: P
authors.lastname: Vandel
authors.forename: J
authors.initials: J
authors.lastname: Galmiche
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D003071:Cognition / Q000502:physiology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004522:Educational Status; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D012372:ROC Curve; D012016:Reference Values; D018401:Sample Size; D014145:Trail Making Test