title: Toxicology and risk assessment of 5-Hydroxymethylfurfural in food.
abstract: 5-Hydroxymethylfurfural (5-HMF) as a product of the Maillard reaction is found in many foods. Estimated intakes range between 4 and 30  mg per person and day, while an intake of up to 350  mg can result from, e.g., beverages made from dried plums. In vitro genotoxicity was positive when the metabolic preconditions for the formation of the reactive metabolite 5-sulphoxymethylfurfural were met. However, so far in vivo genotoxicity was negative. Results obtained in short-term model studies for 5-HMF on the induction of neoplastic changes in the intestinal tract were negative or cannot be reliably interpreted as "carcinogenic". In the only long-term carcinogenicity study in rats and mice no tumours or their precursory stages were induced by 5-HMF aside from liver adenomas in female mice, the relevance of which must be viewed as doubtful. Hence, no relevance for humans concerning carcinogenic and genotoxic effects can be derived. The remaining toxic potential is rather low. Various animal experiments reveal that no adverse effect levels are in the range of 80-100  mg/kg body weight and day. Safety margins are generally sufficient. However, 5-HMF exposure resulting from caramel colours used as food additives should be further evaluated.
authors.affiliation: Department of Food Safety, Federal Institute for Risk Assessment, Germany. klaus-erich.appel@bfr.bund.de
authors.forename: Klaus
authors.initials: K
authors.lastname: Abraham
authors.forename: Rainer
authors.initials: R
authors.lastname: Gürtler
authors.forename: Katharina
authors.initials: K
authors.lastname: Berg
authors.forename: Gerhard
authors.initials: G
authors.lastname: Heinemeyer
authors.forename: Alfonso
authors.initials: A
authors.lastname: Lampen
authors.forename: Klaus E
authors.initials: KE
authors.lastname: Appel
mesh_terms: D000818:Animals; D001628:Beverages / Q000032:analysis; D003110:Colonic Neoplasms / Q000139:chemically induced; D005421:Flavoring Agents / Q000633:toxicity; D005503:Food Additives / Q000633:toxicity; D005504:Food Analysis; D005662:Furaldehyde / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D051379:Mice; D009152:Mutagenicity Tests; D011230:Precancerous Conditions / Q000139:chemically induced; D051381:Rats; D018570:Risk Assessment
chemical_list: D005421:Flavoring Agents; D005503:Food Additives; C008046:5-hydroxymethylfurfural; D005662:Furaldehyde