title: Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy.
abstract: Plasmablastic lymphoma is a rare and aggressive malignancy strongly associated with HIV infection. The refractory/relapsed disease rate is high, and the survival rate is characteristically poor. There are no satisfactory salvage regimens for relapsed cases. We successfully performed autologous stem cell transplantation using a regimen consisting of MCNU (ranimustine), etoposide, cytarabine, and melphalan in a Japanese patient with relapsed AIDS-related plasmablastic lymphoma of the oral cavity. Highly active antiretroviral therapy continued during the therapy. Therapy-related toxicity was tolerable, and a total of 40 Gy of irradiation was administered after autologous stem cell transplantation. The patient has remained in complete remission for 16 months since transplantation.
authors.affiliation: Division of Hematology, Internal Medicine, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo;
authors.forename: Hiroki
authors.initials: H
authors.lastname: Goto
authors.forename: Shotaro
authors.initials: S
authors.lastname: Hagiwara
authors.forename: Risen
authors.initials: R
authors.lastname: Hirai
authors.forename: Takahiko
authors.initials: T
authors.lastname: Miyama
authors.forename: Haruhito
authors.initials: H
authors.lastname: Honda
authors.forename: Amane
authors.initials: A
authors.lastname: Tagashira
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iizuka
authors.forename: Makoto
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Katsuji
authors.initials: K
authors.lastname: Teruya
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oka
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Miwa