title: In vitro amoebicidal activity of borage (Borago officinalis) extract on Entamoeba histolytica.
abstract: Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC₅₀) of the extract for Entamoeba histolytica was 33 μg/mL. The 50% lethal dose of the extract for brine shrimp was greater than 1,000 μg/mL. The IC₅₀ of the extract for Vero cells was 203.9 μg/mL. These results support the use of borage to prevent diseases associated with E. histolytica infection.
authors.affiliation: Faculty of Biological Sciences, Universidad Autonoma de Nuevo Leon, Pedro de Alba y Manuel L. Barragan, Ciudad Universitaria, San Nicolas de los Garza, Nuevo Leon, Mexico.
authors.forename: Catalina
authors.initials: C
authors.lastname: Leos-Rivas
authors.forename: M Julia
authors.initials: MJ
authors.lastname: Verde-Star
authors.forename: Lidia Osuna
authors.initials: LO
authors.lastname: Torres
authors.forename: Azucena
authors.initials: A
authors.lastname: Oranday-Cardenas
authors.forename: Catalina
authors.initials: C
authors.lastname: Rivas-Morales
authors.forename: M Porfiria
authors.initials: MP
authors.lastname: Barron-Gonzalez
authors.forename: Mario R
authors.initials: MR
authors.lastname: Morales-Vallarta
authors.forename: Delia E
authors.initials: DE
authors.lastname: Cruz-Vega
mesh_terms: D000563:Amebicides / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001156:Artemia / Q000187:drug effects; D029683:Borago / Q000737:chemistry*; D002522:Chlorocebus aethiops; D004748:Entamoeba histolytica / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D007928:Lethal Dose 50; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D014709:Vero Cells
chemical_list: D000563:Amebicides; D010936:Plant Extracts