title: Product selectivity control induced by using liquid-liquid parallel laminar flow in a microreactor.
abstract: Product selectivity control based on a liquid-liquid parallel laminar flow has been successfully demonstrated by using a microreactor. Our electrochemical microreactor system enables regioselective cross-coupling reaction of aldehyde with allylic chloride via chemoselective cathodic reduction of substrate by the combined use of suitable flow mode and corresponding cathode material. The formation of liquid-liquid parallel laminar flow in the microreactor was supported by the estimation of benzaldehyde diffusion coefficient and computational fluid dynamics simulation. The diffusion coefficient for benzaldehyde in Bu(4)NClO(4)-HMPA medium was determined to be 1.32 × 10(-7) cm(2) s(-1) by electrochemical measurements, and the flow simulation using this value revealed the formation of clear concentration gradient of benzaldehyde in the microreactor channel over a specific channel length. In addition, the necessity of the liquid-liquid parallel laminar flow was confirmed by flow mode experiments.
authors.affiliation: Department of Electronic Chemistry, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, 2268502, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Amemiya
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Keishi
authors.initials: K
authors.lastname: Fuse
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Kashiwagi
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kuroda
authors.forename: Toshio
authors.initials: T
authors.lastname: Fuchigami
authors.forename: Mahito
authors.initials: M
authors.lastname: Atobe
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D000498:Allyl Compounds / Q000737:chemistry; D001547:Benzaldehydes / Q000737:chemistry; D004058:Diffusion; D004563:Electrochemistry; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D025202:Molecular Diagnostic Techniques; D015394:Molecular Structure
chemical_list: D000438:Alcohols; D000447:Aldehydes; D000498:Allyl Compounds; D001547:Benzaldehydes; C032175:benzaldehyde; C023698:allyl chloride