title: Fischerisin A and B, cytotoxic sesquiterpenoid-geranylhydroquinones from Ligularia fischeri.
abstract: During the course of screening natural sesquiterpenoids for new antitumor agents, two novel compounds, fischerisin A (1) and fischerisin B (2), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by interpretation of their IR, high resolution-mass spectrometry (HR-MS), 1D- and 2D-NMR data. Fischerisin A and B are the first representatives of a novel sesquiterpenoid-geranylhydroquinone hybrid, and both compounds exhibited in vitro cytotoxicity against cultured human oral epidermoid carcinoma (KB) and human breast cancer (MCF-7) cell lines with IC(50) values of 9.7 and 10.2 µM, and 9.8 and 17.8 µM, respectively.
authors.affiliation: Marine College, Shandong University at Weihai, P.R. China. wdxie@sdu.edu.cn
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Xie
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Cheng-Wu
authors.initials: CW
authors.lastname: Weng
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Liu
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Row
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D013055:Spectrophotometry, Infrared; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; D013729:Terpenes; C559421:fischerisin A; C559422:fischerisin B; C026301:geranylhydroquinone