title: Comparative study of hops-containing products on human cytochrome P450-mediated metabolism.
abstract: The potential for 15 different ales (6), ciders (2 apple and 1 pear), and porters (6) and 2 non-alcoholic products to affect cytochrome P450 (CYP)-mediated biotransformation and P-glycoprotein-mediated efflux of rhodamine was examined. As in our previous study, a wide range of recovered nonvolatile suspended solids dry weights were noted. Aliquots were also found to have varying effects on biotransformation and efflux. Distinct differences in product ability to affect the safety and efficacy of therapeutic products confirmed our initial findings that some porters (stouts) have a potential to affect the safety and efficacy of health products metabolized by CYP2D6 and CYP3A4 isozymes. Most products, except 2 of the ciders and the 2 non-alcoholic products, also have the potential to affect the safety of CYP2C9 metabolized medications and supplements. Further studies are required to determine the clinical significance of these findings.
authors.affiliation: Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. brian.foster@hc-sc.gc.ca
authors.forename: Brian C
authors.initials: BC
authors.lastname: Foster
authors.forename: John T
authors.initials: JT
authors.lastname: Arnason
authors.forename: Ammar
authors.initials: A
authors.lastname: Saleem
authors.forename: Teresa W
authors.initials: TW
authors.lastname: Tam
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Jingqin
authors.initials: J
authors.lastname: Mao
authors.forename: Suzanne
authors.initials: S
authors.lastname: Desjardins
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000434:Alcoholic Beverages / Q000032:analysis*; D001189:Aryl Hydrocarbon Hydroxylases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D065729:Cytochrome P-450 CYP2C9; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism*; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism*; D065692:Cytochrome P-450 CYP3A Inhibitors; D004791:Enzyme Inhibitors / Q000032:analysis / Q000494:pharmacology; D006801:Humans; D027582:Humulus / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D065692:Cytochrome P-450 CYP3A Inhibitors; D004791:Enzyme Inhibitors; D010936:Plant Extracts; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; D019389:Cytochrome P-450 CYP2D6; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human