title: [Expression and clinical significance of human nuclear distribution C in nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of human nuclear distribution (hNudC) in nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  Immunohistochemical and western blot method were used to determine the expression of human nuclear distribution C in 80 cases of NPC and 30 cases of chronic inflammation of nasopharyngeal mucosa. The amounts of positive cells were analyzed . The relationship between the gene expression and clinic pathological features was analyzed too.
  
  
  RESULTS
  The positive expression rate of human nuclear distribution C in NPC was 83.75%, which was higher than that in chronic inflammation of nasopharyngeal mucosa 23.33% (P < 0.05). The expression of human nuclear distribution C was positively correlated with the clinic pathological stages in NPC (P < 0.05), and positive expression rate of hNudC protein was increased with the progress of NPC clinical stage (P < 0.05).
  
  
  CONCLUSIONS
  Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia. This protein is important indicators to predict the progression of patients.
authors.affiliation: Guangzhou Women and Children's Medical Center, Guangzhou, 510080, China. frankcyq2002@yahoo.com.cn
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Lin
authors.forename: Hua
authors.initials: H
authors.lastname: Peng
authors.forename: Hangui
authors.initials: H
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D018797:Cell Cycle Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000378:metabolism*; D011379:Prognosis; D055815:Young Adult
chemical_list: D018797:Cell Cycle Proteins; C512648:NUDC protein, human; D009687:Nuclear Proteins