title: Fluconazole-, amphotericin-B-, caspofungin-, and anidulafungin-resistant Candida ciferrii: an unknown cause of systemic mycosis in a child.
abstract: Candida ciferrii, which is known as an agent of superficial yeast infection and onychomycosis, has rarely been isolated as an agent of candidemia. Limited reports have suggested different patterns of antifungal sensitivity. We report a rare candidemia case caused by c.ciferrii in an 8-year-old child in which isolated candida species were resistant to amphotericin-B (MIC > 1 μg/ml), fluconazole, (MIC ≥ 64 μg/ml), caspofungin (MIC ≥ 32 μg/ml), and anidulafungin (MIC ≥ 32 μg/ml) but sensitive to voriconazole (MIC ≤ 0.12 μg/ml). As far as we aware, this was the first recorded C. ciferrii candidemia case in children.
authors.affiliation: Department of Pediatrics, Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Agın
authors.forename: Yüce
authors.initials: Y
authors.lastname: Ayhan
authors.forename: Ilker
authors.initials: I
authors.lastname: Devrim
authors.forename: Gamze
authors.initials: G
authors.lastname: Gülfidan
authors.forename: Sener
authors.initials: S
authors.lastname: Tulumoglu
authors.forename: Ertan
authors.initials: E
authors.lastname: Kayserili
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification*; D058387:Candidemia / Q000175:diagnosis* / Q000382:microbiology*; D002648:Child; D026141:Drug Resistance, Multiple, Fungal; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents