title: Creation of nanostructures by interference lithography for modulation of cell behavior.
abstract: Emerging evidence of the striking differences that can be induced in the behavior of biological cells through topographical modulation of physically and chemically patterned nanostructured surfaces provides a great impetus for developing novel cellular-scale and sub-cellular-scale nanopatterned substrates and for employing them for exciting new applications in life and medical sciences and biotechnology. However, the lack of availability of cost-effective, large-surface-area nanofabricated substrates of appropriate dimensions and features has proved to be a major impediment for research in this area. Here, we demonstrate a simple and cost-effective method based on interference lithography to produce spatially precise and wide-surface-coverage silicon- and polymer-based nanostructures to study how cells react to nanoscale structures or surfaces.
authors.affiliation: NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore.
authors.forename: M
authors.initials: M
authors.lastname: Zhu
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: M K
authors.initials: MK
authors.lastname: Dawood
authors.forename: G
authors.initials: G
authors.lastname: Wan
authors.forename: C Q
authors.initials: CQ
authors.lastname: Lai
authors.forename: H
authors.initials: H
authors.lastname: Cheng
authors.forename: K C
authors.initials: KC
authors.lastname: Leong
authors.forename: R
authors.initials: R
authors.lastname: Rajagopalan
authors.forename: H P
authors.initials: HP
authors.lastname: Too
authors.forename: W K
authors.initials: WK
authors.lastname: Choi
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049452:Green Fluorescent Proteins / Q000737:chemistry; D051379:Mice; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D012117:Resins, Synthetic / Q000737:chemistry; D012825:Silicon / Q000737:chemistry; D013499:Surface Properties
chemical_list: D012117:Resins, Synthetic; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; C029945:polyimide resin; D012825:Silicon