title: PANDER KO mice on high-fat diet are glucose intolerant yet resistant to fasting hyperglycemia and hyperinsulinemia.
abstract: The recent creation of the PANDER (pancreatic-derived factor) knockout (PANKO) and acute mouse models have revealed a biological function in the regulation of glycemic levels via promotion of hepatic glucose production (HGP) and pancreatic β-cell insulin secretion. Therefore, we hypothesized that the absence of PANDER may afford some degree of protection from high-fat diet (HFD) induced fasting hyperglycemia. On HFD, fasting glycemic levels were significantly lower in the PANKO mice. Also, fasting insulin levels and the in vivo insulin response following glucose injection were inhibited in PANKO mice. The lowered fasting glycemic levels are attributed to decreased HGP due to the absence of PANDER. Overall, our findings further indicate PANDER impacts glycemic levels and may represent a potential but complicated therapeutic target.
authors.affiliation: Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, United States.
authors.forename: Claudia E
authors.initials: CE
authors.lastname: Robert-Cooperman
authors.forename: Camella G
authors.initials: CG
authors.lastname: Wilson
authors.forename: Brant R
authors.initials: BR
authors.lastname: Burkhardt
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D016207:Cytokines / Q000172:deficiency* / Q000235:genetics; D004041:Dietary Fats / Q000008:administration & dosage / Q000633:toxicity; D004797:Enzyme-Linked Immunosorbent Assay; D005215:Fasting / Q000097:blood; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance / Q000097:blood* / Q000209:etiology / Q000235:genetics; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000097:blood* / Q000209:etiology / Q000235:genetics; D006946:Hyperinsulinism / Q000097:blood* / Q000209:etiology / Q000235:genetics; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D004041:Dietary Fats; D007328:Insulin; C504749:PANDER protein, mouse; D005947:Glucose