title: Quantitative Perfusion Scintigraphy or Anatomic Segment Method in lung cancer resection.
abstract: BACKGROUND
  Quantitative Perfusion Scintigraphy (QPS) and Anatomic Segment Method (ASM) are two techniques for estimating postoperative pulmonary function. QPS is gold standard, but holds disadvantages.
  
  
  OBJECTIVE
  Could ASM substitute QPS in the preoperative work-up of NSCLC?
  
  
  METHODS
  Retrospective study in patients with NSCLC or mesothelioma undergoing resection. FEV1 and DL,CO were estimated by QPS and ASM and compared to pulmonary function measured 3 months after resection. Correlation tests and Bland-Altman analyses were performed.
  
  
  RESULTS
  40 patients (23 lobectomies, 14 pneumonectomies). Both methods correlated similarly with postoperative FEV(1) (QPSρ=0.69; ASMρ=0.75) and DL,CO (QPSρ=0.70; ASMρ=0.74). Correlation between both methods was high (ppoFEV(1)ρ=0.89; ppoDL,COρ=0.89). The same principles applied in a subgroup analysis of patients with COPD. Bland-Altman analyses showed that ASM underestimated postoperative FEV(1) and DL,CO more than QPS in all groups.
  
  
  CONCLUSIONS
  QPS and ASM are remarkably similar in predicting postoperative pulmonary function. As ASM underestimates pulmonary function more, it could be a safe alternative from a cost-benefit point of view. Based on these results, it appears that QPS could be restricted to patients in whom ASM suggests functional inoperability, although further prospective studies are necessary.
authors.affiliation: Faculty of Medicine and Health Sciences, Ghent University, Belgium. T.Holvoet@UGent.be
authors.forename: Tom
authors.initials: T
authors.lastname: Holvoet
authors.forename: Jan P
authors.initials: JP
authors.lastname: van Meerbeeck
authors.forename: Christophe
authors.initials: C
authors.lastname: Van De Wiele
authors.forename: Bihiyga
authors.initials: B
authors.lastname: Salhi
authors.forename: Eric
authors.initials: E
authors.lastname: Derom
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D054893:Cone-Beam Computed Tomography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D055420:Perfusion Imaging; D019990:Perioperative Care; D011013:Pneumonectomy; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D012129:Respiratory Function Tests / Q000379:methods; D012189:Retrospective Studies