title: Pathophysiological functions of the CagA oncoprotein during infection by Helicobacter pylori.
abstract: Infection with Helicobacter pylori cagA-positive strains plays an essential role in the development of gastric carcinoma. This review summarizes the pathophysiological functions of the cagA gene product, CagA, particularly focusing on the molecular mechanisms underlying CagA translocation into the host cells as well as CagA-mediated deregulation of host cell signaling.
authors.affiliation: Division of Microbiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. naokokam@m.u-tokyo.ac.jp
authors.forename: Naoko
authors.initials: N
authors.lastname: Murata-Kamiya
mesh_terms: D000942:Antigens, Bacterial / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D002277:Carcinoma / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D008954:Models, Biological; D015513:Oncogene Proteins / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000382:microbiology* / Q000473:pathology; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D015513:Oncogene Proteins; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori