title: A fuzzy-based data transformation for feature extraction to increase classification performance with small medical data sets.
abstract: OBJECTIVE
  Medical data sets are usually small and have very high dimensionality. Too many attributes will make the analysis less efficient and will not necessarily increase accuracy, while too few data will decrease the modeling stability. Consequently, the main objective of this study is to extract the optimal subset of features to increase analytical performance when the data set is small.
  
  
  METHODS
  This paper proposes a fuzzy-based non-linear transformation method to extend classification related information from the original data attribute values for a small data set. Based on the new transformed data set, this study applies principal component analysis (PCA) to extract the optimal subset of features. Finally, we use the transformed data with these optimal features as the input data for a learning tool, a support vector machine (SVM). Six medical data sets: Pima Indians' diabetes, Wisconsin diagnostic breast cancer, Parkinson disease, echocardiogram, BUPA liver disorders dataset, and bladder cancer cases in Taiwan, are employed to illustrate the approach presented in this paper.
  
  
  RESULTS
  This research uses the t-test to evaluate the classification accuracy for a single data set; and uses the Friedman test to show the proposed method is better than other methods over the multiple data sets. The experiment results indicate that the proposed method has better classification performance than either PCA or kernel principal component analysis (KPCA) when the data set is small, and suggest creating new purpose-related information to improve the analysis performance.
  
  
  CONCLUSIONS
  This paper has shown that feature extraction is important as a function of feature selection for efficient data analysis. When the data set is small, using the fuzzy-based transformation method presented in this work to increase the information available produces better results than the PCA and KPCA approaches.
authors.affiliation: Department of Industrial and Information Management, National Cheng Kung University, 1, University Road, Tainan 70101, Taiwan. lidc@mail.ncku.edu.tw
authors.forename: Der-Chiang
authors.initials: DC
authors.lastname: Li
authors.forename: Chiao-Wen
authors.initials: CW
authors.lastname: Liu
authors.forename: Susan C
authors.initials: SC
authors.lastname: Hu
mesh_terms: D002965:Classification / Q000379:methods*; D016208:Databases, Factual; D017143:Fuzzy Logic; D006801:Humans; D009369:Neoplasms / Q000145:classification; D025341:Principal Component Analysis; D013223:Statistics as Topic; D013624:Taiwan; D014922:Wisconsin