title: The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model.
abstract: OBJECTIVE
  To investigate the levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA) in all the rat endometriosis models.
  
  
  METHODS
  Forty-one rats with endometriotic implants were divided into four groups (1 to 4) and administered infliximab, etanercept, letrozole and control, respectively. There were 11 rats in group 5 (normal). The size of implants, plasma ADMA and nitrate/nitrite (NO(x) ) levels and histological score were assessed.
  
  
  RESULTS
  In groups 1, 2 and 3, plasma ADMA levels were higher than groups 4 and 5, 296.8 ± 66.2, 285.9 ± 35.7, 200.3 ± 41.0, 125.3 ± 16.7, 111.3 ± 6.5 µmol/L, respectively, while NO(x) levels were lower than groups of control and normal 19.6 ± 3.8, 19.8 ± 4.4, 39.3 ± 6.1, 80.5 ± 5.3, and 91.1 ± 5.0 µmol/L, respectively.
  
  
  CONCLUSIONS
  Infliximab, etanercept and letrozole have regressed endometriotic implants, decreased plasma NO(x) levels, and increased plasma ADMA levels.
authors.affiliation: Department of Medical Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Tuncer
authors.initials: T
authors.lastname: Cayci
authors.forename: Emin Ozgur
authors.initials: EO
authors.lastname: Akgul
authors.forename: Yasemin Gulcan
authors.initials: YG
authors.lastname: Kurt
authors.forename: Temel S
authors.initials: TS
authors.lastname: Ceyhan
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Aydin
authors.forename: Onder
authors.initials: O
authors.lastname: Onguru
authors.forename: Halil
authors.initials: H
authors.lastname: Yaman
authors.forename: Erdinc
authors.initials: E
authors.lastname: Cakir
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yasar
authors.forename: Cumhur
authors.initials: C
authors.lastname: Bilgi
authors.forename: Kemal M
authors.initials: KM
authors.lastname: Erbil
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D004195:Disease Models, Animal; D004715:Endometriosis / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D009569:Nitric Oxide / Q000097:blood*; D010532:Peritoneal Diseases / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D001120:Arginine