title: Anti-inflammatory plasma cytokines in children and adolescents with Down syndrome.
abstract: Cytokines participate in many physiological processes including the regulation of immune and inflammatory responses. Production of some important cytokines in children with Down syndrome (DS) is depressed or increased. In this study we analysed the selected anti- inflammatory cytokines: interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-13 (IL-13) in plasma of children and adolescents with DS. The study group consisted of 20 patients with Down syndrome and 33 healthy subjects at the age of 5-17 years. Levels of: IL-4, IL-10 and IL-13 in plasma samples were determined by specific enzyme- linked immunosorbent assay (ELISA) techniques according to manufacturer's instructions. IL-4 was detectable in 25% subjects with Down syndrome and in 28.6% healthy subjects. IL-13 was detectable in 15% patients with Down syndrome and in 15.2% healthy subjects, respectively. IL-10 was detectable in 1 of 20 patients with Down syndrome and in 2 of 33 healthy subjects only. No significant correlations between measurable cytokine levels and age and gender were found. No significant increased concentration of selected anti- inflammatory cytokines were detected.
authors.affiliation: Department of Pediatric Neurology and Rehabilitation, Medical University of Białystok, Poland. jsmig1@poczta.onet.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Smigielska-Kuzia
authors.forename: Leszek
authors.initials: L
authors.lastname: Boćkowski
authors.forename: Wojciech
authors.initials: W
authors.lastname: Sobaniec
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sendrowski
authors.forename: Beata
authors.initials: B
authors.lastname: Zelazowska-Rutkowska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Cholewa
mesh_terms: D000293:Adolescent; D002648:Child; D016207:Cytokines / Q000097:blood*; D004314:Down Syndrome / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D018793:Interleukin-13 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008297:Male
chemical_list: D016207:Cytokines; D018793:Interleukin-13; D016753:Interleukin-10; D015847:Interleukin-4