title: Glutathione depression by dihydropyrazine derivative.
abstract: Dihydropyrazine (DHP), which is formed by nonenzymatic glycation, generates various radical species that lead to DNA damage and enzyme inhibition. In this study, we examined the reaction between DHP derivatives and glutathione (GSH). DHP exposure caused more intense growth inhibition of a GSH-deficient mutant Escherichia coli strain compared with the wild-type strain. DHP-exposed mouse fibroblasts showed a decrease in the cellular GSH level. The obtained data suggested that the reaction of DHP with GSH possibly potentiates cellular stress via the depletion of cellular GSH levels.
authors.forename: Shinji
authors.initials: S
authors.lastname: Takechi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ito
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kashige
authors.forename: Takumi
authors.initials: T
authors.lastname: Ishida
authors.forename: Tadatoshi
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D016475:3T3 Cells; D000818:Animals; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D051379:Mice; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D011719:Pyrazines / Q000378:metabolism* / Q000633:toxicity*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D011719:Pyrazines; D017382:Reactive Oxygen Species; D005978:Glutathione