title: Time course of plasma leptin concentrations after acute spontaneous basal ganglia hemorrhage.
abstract: BACKGROUND
  Brain cortex leptin messenger ribonucleic acid (mRNA) expression and serum leptin level are up-regulated in ischemic mouse brain, as well as in rat brain with traumatic brain injury. Elevated leptin plasma levels predict cerebral hemorrhagic stroke independently of traditional risk factors. The goal of this study was to investigate change in plasma leptin level after intracerebral hemorrhage (ICH) and to evaluate its relation with disease outcome.
  
  
  METHODS
  Eighty-six patients admitted within 6 hrs after ICH and 30 healthy controls were included. Plasma samples were obtained on admission and at days 1, 2, 3, 5, and 7 after ICH. Its concentration was measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  After ICH, plasma leptin level in patients increased during the 6-hour period immediately, peaked in 24 hours, decreased gradually thereafter, and was substantially higher than that in healthy controls during the 7-day period. Plasma leptin levels were highly associated with initial Glasgow coma scores, ICH volumes, presence of intraventricular hemorrhage, and survival rates (all P < 0.05). A multivariate analysis selected plasma leptin level related to plasma C-reactive protein level (standardized coefficient, 0.293; P = 0.003). A multivariate analysis showed baseline plasma leptin level as a good predictor for 1-week mortality (odds ratio, 1.228; 95% confidence interval, 1.070-1.409; P = 0.003). A receiver operating characteristic curve identified that a baseline plasma leptin level greater than 34.1 ng/mL predicted 1-week mortality of patients with 75.0% sensitivity and 85.2% specificity (P < 0.001). Area under curve of GCS score was statistically significantly larger than that of plasma leptin level (P = 0.035), but ICH volume's area under curve not (P = 0.078).
  
  
  CONCLUSIONS
  Increased plasma leptin level is found after ICH and may contribute to inflammatory process of ICH, in association with a poor clinical outcome.
authors.affiliation: Department of Neurosurgery, The First Hangzhou Municipal People's Hospital, Nanjing Medical University, Hangzhou, China. dxqhyy@163.com
authors.forename: Xiao-Qiao
authors.initials: XQ
authors.lastname: Dong
authors.forename: Man
authors.initials: M
authors.lastname: Huang
authors.forename: Yue-Yu
authors.initials: YY
authors.lastname: Hu
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Yu
authors.forename: Zu-Yong
authors.initials: ZY
authors.lastname: Zhang
mesh_terms: D000368:Aged; D020145:Basal Ganglia Hemorrhage / Q000097:blood* / Q000401:mortality / Q000628:therapy; D015415:Biomarkers; D001774:Blood Chemical Analysis; D003131:Combined Modality Therapy; D023381:Endpoint Determination; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015600:Glasgow Coma Scale; D006439:Hemodynamics; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D013534:Survival; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D020738:Leptin