title: An improved Larock synthesis of quinolines via a Heck reaction of 2-bromoanilines and allylic alcohols.
abstract: A modified Larock method has been developed for the one-pot synthesis of substituted quinolines via a Heck reaction of 2-bromoanilines and allylic alcohols followed by dehydrogenation with diisopropyl azodicarboxylate (DIAD).
authors.affiliation: Department of Chemistry and Novartis Center for Continuous Manufacturing, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States. matthew.stone@merckgroup.com
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Stone
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry; D017605:Bromine Compounds / Q000737:chemistry*; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis*
chemical_list: D000814:Aniline Compounds; D001391:Azo Compounds; D017605:Bromine Compounds; D020005:Propanols; D011804:Quinolines; C006463:allyl alcohol