title: The Rat Genome Database pathway portal.
abstract: The set of interacting molecules collectively referred to as a pathway or network represents a fundamental structural unit, the building block of the larger, highly integrated networks of biological systems. The scientific community's interest in understanding the fine details of how pathways work, communicate with each other and synergize, and how alterations in one or several pathways may converge into a disease phenotype, places heightened demands on pathway data and information providers. To meet such demands, the Rat Genome Database [(RGD) http://rgd.mcw.edu] has adopted a multitiered approach to pathway data acquisition and presentation. Resources and tools are continuously added or expanded to offer more comprehensive pathway data sets as well as enhanced pathway data manipulation, exploration and visualization capabilities. At RGD, users can easily identify genes in pathways, see how pathways relate to each other and visualize pathways in a dynamic and integrated manner. They can access these and other components from several entry points and effortlessly navigate between them and they can download the data of interest. The Pathway Portal resources at RGD are presented, and future directions are discussed. Database URL: http://rgd.mcw.edu.
authors.affiliation: Human and Molecular Genetics Center, Medical College of Wisconsin, WI, 53226-3548, USA. vpetri@mcw.edu
authors.forename: Victoria
authors.initials: V
authors.lastname: Petri
authors.forename: Mary
authors.initials: M
authors.lastname: Shimoyama
authors.forename: G Thomas
authors.initials: GT
authors.lastname: Hayman
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Smith
authors.forename: Marek
authors.initials: M
authors.lastname: Tutaj
authors.forename: Jeff
authors.initials: J
authors.lastname: de Pons
authors.forename: Melinda R
authors.initials: MR
authors.lastname: Dwinell
authors.forename: Diane H
authors.initials: DH
authors.lastname: Munzenmaier
authors.forename: Simon N
authors.initials: SN
authors.lastname: Twigger
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Jacob
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D053263:Gene Regulatory Networks / Q000235:genetics; D016678:Genome / Q000235:genetics*; D006801:Humans; D020407:Internet; D008297:Male; D058977:Molecular Sequence Annotation; D011471:Prostatic Neoplasms / Q000235:genetics; D051381:Rats; D015398:Signal Transduction / Q000235:genetics*