title: [EBV-associated B-cell lymphoproliferative disorder of the elderly successfully treated with autologous peripheral blood stem cell transplantation and locoregional radiotherapy].
abstract: Age-related EBV-associated B-cell lymphoproliferative disorder is a highly aggressive lymphoma, and a standard therapy for this disease has not yet been established. A 58-year-old male was admitted to our hospital because of fever and lymphadenopathy across the whole body. Neck lymph node biopsy showed hemorrhagic and geographic necrosis with Hodgkin-like large cells against a background of small lymphocytes. The large cells were positive for CD30 and EBER. The patient was diagnosed as having age-related EBV-associated B-cell lymphoproliferative disorder. Although there was no response to CHOP therapy, he obtained partial response after 3 courses of DeVIC therapy. Because his lymphoma was highly aggressive and chemotherapy-resistant, he underwent autologous stem cell transplantation with a conditioning regimen including ranimustine, etoposide, cytarabine, and melphalan. After stem cell transplantation and subsequent radiotherapy to the residual lesion, the patient achieved complete remission. This is the first report of successful autologous stem cell transplantation for a patient with age-related EBV-associated B-cell lymphoproliferative disorder.
authors.affiliation: Department of Hematology, Osaka Red Cross Hospital.
authors.forename: Noriko
authors.initials: N
authors.lastname: Sugino
authors.forename: Chishiho
authors.initials: C
authors.lastname: Nakamura
authors.forename: Sumie
authors.initials: S
authors.lastname: Fujii
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Matsui
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kaneko
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Watanabe
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Miura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Wakasa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Tsudo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001402:B-Lymphocytes; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D004854:Herpesvirus 4, Human; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008232:Lymphoproliferative Disorders / Q000628:therapy* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D018714:Radiotherapy, Adjuvant; D016879:Salvage Therapy; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D005047:Etoposide; D003907:Dexamethasone; D016190:Carboplatin; D007069:Ifosfamide