title: Incidence, risk factors for amputation among patients with diabetic foot ulcer in a Chinese tertiary hospital.
abstract: OBJECTIVE
  The aim of this study was to evaluate the incidence of amputation among patients with diabetic foot ulcer (DFU) and risk factors for amputations.
  
  
  METHODS
  This is a retrospective study of 450 inpatients treated in a multi-discipline based diabetic centre, 306th Hospital of PLA during the period of January 2000-September 2009. Hospital admission and discharge information including patient profile, grade of DFU, co-morbidities and complications, laboratory data and final outcome were collected. The risk factors for amputation were determined using univariate and stepwise logistic regression analysis.
  
  
  RESULTS
  The overall amputation rate among DFU was 21.5%. Significant univariate risk factors for amputation were peripheral vascular disease (PVD), white blood cell (WBC) counts, neutrophil granulocyte percentage, hemoglobin, triglyceride, cholesterol, LDL-C, HDL-C and serum sCRP. Upon stepwise logistic regression analysis, only PVD (odds ratio 4.529, 95% CI 1.500-13.676), WBC (odds ratio 1.146, 95% CI 1.075-1.222), sCRP (odds ratio 1.041, 95% CI 1.002-1.082) and triglyceride (odds ratio -0.488, 95% CI 0.433-0.869) were significant risk factors.
  
  
  CONCLUSIONS
  The risk factors for amputation were presence of PVD, increased WBC, sCRP and decreased triglyceride.
authors.affiliation: Diabetes Centre, 306th Hospital of PLA, No. 9 Anxiangbeilu, Chaoyang District, Beijing 100101, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Ting
authors.initials: T
authors.lastname: Xiao
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Wang
authors.forename: Hongbin
authors.initials: H
authors.lastname: Gu
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Liu
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Liu
authors.forename: Zuqian
authors.initials: Z
authors.lastname: Lu
authors.forename: Xiaopin
authors.initials: X
authors.lastname: Yang
authors.forename: Yin
authors.initials: Y
authors.lastname: Lan
authors.forename: Zhangrong
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D017719:Diabetic Foot / Q000453:epidemiology* / Q000601:surgery*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult