title: Extreme obesity and associated cardiovascular disease verified at autopsy: time trends over 3 decades.
abstract: Extreme obesity is a strong predictor of premature death, but the prevalence of cardiovascular disease in morbidly obese populations is largely unknown. The aim of the present study was to find out whether there has been an increase in extreme obesity with body mass index 40.0 kg/m(2) or greater in medicolegal autopsy material in a known geographical area in Finland during a period of 3 decades and to examine the prevalence and time trends of associated cardiovascular disease in this obesity category. Autopsy reports of 235 cases examined in 1975 to 2006 were analyzed. The number of extremely obese individuals increased from 0.6% of the yearly amount of autopsies in the 1970s and 1980s to 2.8% and 2.5% in 2005 and 2006, respectively. The most frequent cause of death was cardiomyopathy or cardiomegaly (28.9%), followed by coronary heart disease (24.3%). Either coronary arteries were lesion-free, or only fatty streaks had been observed in 46.8% of the women and in 43.1% of the men. No significant changes in the average body mass index or severity of coronary atherosclerosis were observed. Younger individuals younger than 40 years began to appear more often after 1995. An increased trend of extreme obesity in a region where autopsy frequency is high may refer to a general increase of this obesity category. A large number of extremely obese people are resistant to coronary atherosclerosis, but cardiac hypertrophy may be accompanied by several mechanisms leading to sudden death even among the youngest extremely obese individuals.
authors.affiliation: Department of Forensic Medicine, Institute of Diagnostics, University of Oulu, Finland. Marja-Leena.Kortelainen@oulu.fi
authors.forename: Marja-Leena
authors.initials: ML
authors.lastname: Kortelainen
authors.forename: Katja
authors.initials: K
authors.lastname: Porvari
mesh_terms: D050153:Abdominal Fat; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015992:Body Mass Index; D002492:Central Nervous System Depressants / Q000097:blood; D003331:Coronary Vessels / Q000473:pathology*; D003920:Diabetes Mellitus / Q000453:epidemiology; D000431:Ethanol / Q000097:blood; D005260:Female; D005387:Finland / Q000453:epidemiology; D049429:Forensic Pathology; D006331:Heart Diseases / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000473:pathology; D009767:Obesity, Morbid / Q000453:epidemiology*; D009929:Organ Size; D055815:Young Adult
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol