title: Serum levels of advanced oxidation protein products, malonyldialdehyde, and total radical trapping antioxidant parameter in patients with chronic hepatitis C.
abstract: OBJECTIVE
  Oxidative stress increases in chronic hepatitis C, and antioxidant defense mechanisms are impaired. The aims of this study were to compare chronic hepatitis C patients and healthy subjects according to oxidative stress and antioxidant system markers, and to determine the relationship between oxidative stress and hepatosteatosis.
  
  
  METHODS
  This is an observational study in a tertiary center. Twenty-nine biopsy-proven chronic hepatitis C patients, with no prior anti-viral treatment and persistently elevated serum transaminase levels for 6 months, were included. The control group included 46 healthy subjects. Advanced oxidation protein products and malonyldialdehyde levels were measured. Total radical-trapping antioxidant parameter was calculated.
  
  
  RESULTS
  Baseline characteristics were similar in the patient and control groups. In chronic hepatitis C patients, serum levels of advanced oxidation protein products were significantly higher than in the control group (235.0±142.8 vs 116.7±79.5, p<0.001). Serum levels of malonyldialdehyde were also significantly higher than in the control group (9.3±2.1 vs 6.5±1.1, p<0.001). However, there was no significant difference in total radical-trapping antioxidant parameter. The total radical-trapping antioxidant parameter/advanced oxidation protein products index was significantly lower in chronic hepatitis C patients than in healthy controls (p<0.05). There was no significant correlation between advanced oxidation protein products and malonyldialdehyde and hepatosteatosis.
  
  
  CONCLUSIONS
  We conclude that oxidative stress occurs in chronic hepatitis C, and antioxidant defense mechanisms are inadequate. Serum levels of advanced oxidation protein products and malonyldialdehyde are higher in chronic hepatitis C patients when compared to healthy individuals, and may be useful markers in chronic hepatitis C.
authors.affiliation: Departments of, Gastroenterology, Gazi University School of Medicine, Ankara. serenozenir@yahoo.com
authors.forename: Seren
authors.initials: S
authors.lastname: Ozenırler
authors.forename: Gülbanu
authors.initials: G
authors.lastname: Erkan
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gülbahar
authors.forename: Ozge
authors.initials: O
authors.lastname: Bostankolu
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ozbaş Demırel
authors.forename: Ayşe
authors.initials: A
authors.lastname: Bılgıhan
authors.forename: Gülen
authors.initials: G
authors.lastname: Akyol
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D016166:Free Radical Scavengers / Q000097:blood*; D019698:Hepatitis C, Chronic / Q000378:metabolism*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001798:Blood Proteins; D016166:Free Radical Scavengers; D008315:Malondialdehyde