title: The dual role of the X-linked FoxP3 gene in human cancers.
abstract: The FoxP3 (forkhead box P3) gene is an X-linked gene that is submitted to inactivation. It is an essential transcription factor in CD4(+)CD25(+)FoxP3 regulatory T cells, which are therapeutic targets in disseminated cutaneous melanoma. Moreover, FoxP3 is an important tumor suppressor gene in carcinomas and has putative cancer suppressor gene function in cutaneous melanoma as well. Therefore understanding the structure and function of the FoxP3 gene is crucial to gaining insight into the biology of melanoma to better develop immunotherapeutics and future therapeutic strategies.
authors.affiliation: Department of Pathology, McGill University, Montreal, QC, Canada.
authors.forename: Margaret
authors.initials: M
authors.lastname: Redpath
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Leon C
authors.initials: LC
authors.lastname: van Kempen
authors.forename: Alan
authors.initials: A
authors.lastname: Spatz
mesh_terms: D000818:Animals; D051858:Forkhead Transcription Factors / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008545:Melanoma / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors