title: Cellular mechanisms of high frequency oscillations in epilepsy: on the diverse sources of pathological activities.
abstract: A major goal in epilepsy research is to understand the cellular basis of pathological forms of network oscillations, particularly those classified as high-frequency activity. What are the underlying mechanisms, and how do they arise? The topic of this review is the pattern of high-frequency oscillations that have been recorded in epileptic tissue, and how they might differ from physiological activity. We discuss recent experimental and clinical data with a major focus on the diverse sources of extracellular signals and the contribution of different neuronal populations, including GABAergic interneurons and glutamatergic principal cells.
authors.affiliation: Instituto Cajal, CSIC, Ave. Doctor Arce 37, Madrid 28002, Spain. lmprida@cajal.csic.es
authors.forename: Liset
authors.initials: L
authors.lastname: Menendez de la Prida
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Trevelyan
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D058256:Brain Waves / Q000187:drug effects / Q000502:physiology*; D003198:Computer Simulation; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology*; D018682:GABA Agents / Q000494:pharmacology; D059330:GABAergic Neurons / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D008959:Models, Neurological; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology
chemical_list: D018682:GABA Agents