title: Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins.
abstract: The manuscript pertains to the synthesis and in vitro cytotoxic evaluation of a series of N-alkylbromo and N-alkylphthalimido-isatins against four different human cancer cell lines namely Colon: HCT-15; Liver: Hep-2; Lung: A-549 and Leukemia: THP-1 at 10 and 100 μM concentrations. The active compounds based on preliminary studies were evaluated for their IC(50) value against six cell lines viz. Colo-205, HCT-15 (Colon), THP-1 (Leukemia), A-549 (Lung), PC-3 (Prostate) and HeLa (Cervix). The active analogue IS-4 exhibited IC(50) values of 4.57, 10.90, 11.75, 12.40 and 54.20 μM against HeLa, PC-3, HCT-15, THP-1 and Colo-205, respectively.
authors.affiliation: Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
authors.forename: Pardeep
authors.initials: P
authors.lastname: Singh
authors.forename: Sharanjeet
authors.initials: S
authors.lastname: Kaur
authors.forename: Vipan
authors.initials: V
authors.lastname: Kumar
authors.forename: P M S
authors.initials: PM
authors.lastname: Bedi
authors.forename: M P
authors.initials: MP
authors.lastname: Mahajan
authors.forename: Irum
authors.initials: I
authors.lastname: Sehar
authors.forename: Harish Chandra
authors.initials: HC
authors.lastname: Pal
authors.forename: Ajit Kumar
authors.initials: AK
authors.lastname: Saxena
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D001966:Bromine / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007510:Isatin / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D015394:Molecular Structure; D010797:Phthalimides / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D010797:Phthalimides; C037431:phthalimide; D007510:Isatin; D001966:Bromine