title: Increased memory Th17 cells in patients with neuromyelitis optica and multiple sclerosis.
abstract: OBJECTIVE
  To investigate the clinical relevance of memory Th17 cells in patients with neuromyelitis optica (NMO) or multiple sclerosis (MS).
  
  
  METHODS
  The proportion of peripheral memory Th17 cells was determined by flow cytometry. Sera IL-17A and IL-23 levels were detected by ELISA kits.
  
  
  RESULTS
  Memory Th17 proportion and IL-17A level were much higher in patients with NMO or MS and were related to clinical features. After high-dose intravenous methylprednisolone (IVMP) therapy, memory Th17 proportion and IL-17A and IL-23 levels were decreased.
  
  
  CONCLUSIONS
  Memory Th17 is related to the development and relapse of NMO and MS, and IVMP can inhibit memory Th17.
authors.affiliation: MS Clinical Research Center, Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Honghao
authors.initials: H
authors.lastname: Wang
authors.forename: Youming
authors.initials: Y
authors.lastname: Long
authors.forename: Zhengqi
authors.initials: Z
authors.lastname: Lu
authors.forename: Xueqiang
authors.initials: X
authors.lastname: Hu
mesh_terms: D000328:Adult; D016207:Cytokines / Q000378:metabolism; D004185:Disability Evaluation; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism; D053759:Interleukin-23 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D009471:Neuromyelitis Optica / Q000473:pathology*; D012720:Severity of Illness Index; D013223:Statistics as Topic; D058504:Th17 Cells / Q000473:pathology*
chemical_list: D016207:Cytokines; D020381:Interleukin-17; D053759:Interleukin-23