title: Acute cerebral infarction and extra pontine myelinolysis in children with new onset type 1 diabetes mellitus.
abstract: Neurological complications of diabetic ketoacidosis (DKA) are still associated with significant mortality and morbidity. We report on two children who suffered from acute cerebral infarction (CI) and extra pontine myelinolysis (EPM) at onset of type 1 diabetes. Initially, clinical management had not been performed according to generally accepted guidelines. Putative risk factors that may have predisposed for the development of acute cerebrovascular complications are discussed. Not only cerebral edema (CE) but also other severe neurological complications such as CI should be suspected when neurological deterioration occurs during DKA. We conclude that not only an exceeded rehydration therapy but also a rapidly reduced serum osmolality due to an unbalanced rapid blood sugar decrease and serum sodium increase may have lead to the neurological disease. We propose that a reserved and well-defined rehydration strategy in the first 6 (-12) h of therapy is crucial for recovery and can reduce neurological complications of patients with DKA.
authors.affiliation: Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Petzold
authors.forename: Thomas
authors.initials: T
authors.lastname: Kapellen
authors.forename: Manuela
authors.initials: M
authors.lastname: Siekmeyer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hirsch
authors.forename: Heike
authors.initials: H
authors.lastname: Bartelt
authors.forename: Werner
authors.initials: W
authors.lastname: Siekmeyer
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
mesh_terms: D000293:Adolescent; D001929:Brain Edema / Q000209:etiology; D002544:Cerebral Infarction / Q000209:etiology*; D002675:Child, Preschool; D003711:Demyelinating Diseases / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D016883:Diabetic Ketoacidosis / Q000150:complications*; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects; D006801:Humans; D008297:Male; D011149:Pons