title: Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites - case report and a literature review.
abstract: In recent years the the set of diagnostic tools in colorectal cancers has been extended by the assessment of the KRAS gene status. Currently it is a necessary step in order to qualify patients for the targeted therapy. The results of the analysis of several studies revealed a high rate of compliance of the KRAS gene mutational status in primary and metastatic tumors. In this paper we present a rare case of incompatibility of the KRAS mutations in the primary tumor located in the colon and metastatic changes in the liver.
authors.affiliation: Department of Gastrointestinal Cancer, Cancer Center-Institute, Warsaw, Poland. ekosakowska@coi.waw.pl
authors.forename: Ewa Anna
authors.initials: EA
authors.lastname: Kosakowska
authors.forename: Rafał
authors.initials: R
authors.lastname: Stec
authors.forename: Radosław
authors.initials: R
authors.lastname: Charkiewicz
authors.forename: Marta
authors.initials: M
authors.lastname: Skoczek
authors.forename: Lech
authors.initials: L
authors.lastname: Chyczewski
mesh_terms: D001483:Base Sequence; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D009362:Neoplasm Metastasis; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins / Q000235:genetics*
chemical_list: C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; D066246:ErbB Receptors; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins