title: [Hypoxic preconditioning is a phenomenon increasing tolerance of cardiomyocytes to hypoxia-reoxygenation].
abstract: The work covers the problem of hypoxic preconditioning (HP) carried out in isolated cardiomyocytes. Papers on delayed HP in vivo are comparatively few, and only some single works are devoted to early preconditioning in vivo. It has been established that the HP limits necrosis and apoptosis of cardiomyocytes and improves contractility of the isolated heart after ischemia (hypoxia) and reperfusion (reoxygenation). It was found that adenosine was a trigger of iP in vitro. It was proved that NO* was a trigger of HP both in vitro and in vivo. It was shown that reactive oxygen species also were triggers of hypoxic preconditioning. It was shown that ERK1/2 and p38 kinase played important role in delayed HP in vitro.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Lishmanov
authors.forename: F
authors.initials: F
authors.lastname: Kolar
authors.forename: A G
authors.initials: AG
authors.lastname: Portnichenko
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Podoksenov
authors.forename: I G
authors.initials: IG
authors.lastname: Khaliulin
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: J M
authors.initials: JM
authors.lastname: Pei
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000503:physiopathology; D032383:Myocytes, Cardiac / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D009569:Nitric Oxide; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D048051:p38 Mitogen-Activated Protein Kinases