title: Cellular response to metal oxide nanoparticles in bacteria.
abstract: The exponential growth in the production and consumption of engineered nanoparticles (ENPs) has raised concern about their environmental fate. ENPs accumulation in ecosystems is likely to pose threat to specific and non-specific targets. In this study a novel approach using flow cytometry was validated for detection of ENPs (ZnO and TiO2) uptake in live bacteria for several generations. These ENPs also induced frameshift mutation in S. typhimurium strains of Ames test, thus underscoring their possible carcinogenic potential.
authors.affiliation: Nanomaterial Toxicology Group, Indian Institute of Toxicology Research (CSIR), P.O. Box 80, M.G. Marg, Lucknow 226001, India.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Kumar
authors.forename: Alok K
authors.initials: AK
authors.lastname: Pandey
authors.forename: Shashi S
authors.initials: SS
authors.lastname: Singh
authors.forename: Rishi
authors.initials: R
authors.lastname: Shanker
authors.forename: Alok
authors.initials: A
authors.lastname: Dhawan
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004926:Escherichia coli / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000633:toxicity*; D009154:Mutation / Q000187:drug effects*; D010087:Oxides / Q000633:toxicity*
chemical_list: D010087:Oxides