title: Associations of physical activity with quality of life and functional ability in breast cancer patients during active adjuvant treatment: the Pathways Study.
abstract: Physical activity can improve quality of life (QOL) in breast cancer survivors but little is known about associations of physical activity and QOL during active cancer therapy. We examine associations between activity levels and QOL in a large cohort of breast cancer patients. Women with invasive, non-metastatic breast cancer (n=2,279) were enrolled between 2006 and 2009 from a managed care organization; assessment were done during active therapy. A physical activity frequency questionnaire was used to calculate the average weekly metabolic equivalent task (MET) hours spent in moderate and vigorous activity during active treatment. QOL was measured by the Functional Assessment of Cancer Therapy-Breast Cancer. Linear regression models tested cross-sectional associations of QOL and functional well-being with physical activity and covariates [socio-demographics, comorbidity, body mass index (BMI), clinical variables, social support, and assessment timing]. Physical activity had a significant positive unadjusted association with all QOL sub-scales (except emotional well-being) (all P values < 0.01). Overall QOL was 4.6 points higher for women in the highest quartile of moderate and vigorous activity versus women in the lowest quartile (P<0.001). In regression models, higher activity was associated with better overall QOL and functional well-being, controlling for covariates (P<0.05). Increasing BMI was also independently but inversely associated with overall QOL (P<0.001) but did not explain the relationship of activity and QOL. White women reported the higher levels of activity than minority women and activity was associated with QOL for Whites but not for minority women. Greater physical activity is associated with small but clinically meaningful increases in QOL during active breast cancer care therapy for Whites but this effect is not seen for minority women. If confirmed in longitudinal analyses, these differences may have implications for disparities research.
authors.affiliation: Cancer Control Program, Lombardi Cancer Center and Department of Oncology, Georgetown University Medical Center, 3300 Whitehaven St. NW, Ste 4100, Washington, DC, 20007, USA. mandelbj@georgetown.edu
authors.forename: Jeanne S
authors.initials: JS
authors.lastname: Mandelblatt
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Luta
authors.forename: Marilyn L
authors.initials: ML
authors.lastname: Kwan
authors.forename: Solomon B
authors.initials: SB
authors.lastname: Makgoeng
authors.forename: Isaac J
authors.initials: IJ
authors.lastname: Ergas
authors.forename: Janise M
authors.initials: JM
authors.lastname: Roh
authors.forename: Barbara
authors.initials: B
authors.lastname: Sternfeld
authors.forename: Lucile L
authors.initials: LL
authors.lastname: Adams-Campbell
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Kushi
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000208:ethnology / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D002140:California / Q000453:epidemiology; D017024:Chemotherapy, Adjuvant; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D004644:Emotions; D005260:Female; D006801:Humans; D016014:Linear Models; D008408:Mastectomy; D008875:Middle Aged; D009043:Motor Activity; D011446:Prospective Studies; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D018570:Risk Assessment; D012307:Risk Factors; D012944:Social Support; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome