title: Drug-induced cholestasis.
abstract: Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.
authors.affiliation: Division of Gastroenterology, Centennial Hills Hospital Medical Center, Las Vegas, NV, USA.
authors.forename: Manmeet S
authors.initials: MS
authors.lastname: Padda
authors.forename: Mayra
authors.initials: M
authors.lastname: Sanchez
authors.forename: Abbasi J
authors.initials: AJ
authors.lastname: Akhtar
authors.forename: James L
authors.initials: JL
authors.lastname: Boyer
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002779:Cholestasis / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism
chemical_list: D002352:Carrier Proteins