title: Effect of acute kidney injury requiring extended dialysis on 28 day and 1 year survival of patients undergoing interventional lung assist membrane ventilator treatment.
abstract: BACKGROUND
  Extracorporeal lung assist devices are increasingly used in the intensive care unit setting to improve extracorporeal gas exchange mainly in patients with acute respiratory distress syndrome. ARDS is frequently accompanied by acute kidney injury; however it is so far unknown how the combination of these two conditions affects long term survival of critically ill patients.
  
  
  METHODS
  In a retrospective analysis of a tertiary care hospital we evaluated all patients undergoing interventional lung assist (iLA) treatment between January 1st 2005 and December 31st 2009. Data from all 61 patients (31 F/30 M), median age 40 (28 to 52) years were obtained by chart review. Follow up data up to one year were obtained.
  
  
  RESULTS
  Of the 61 patients undergoing iLA membrane ventilator treatment 21 patients had acute kidney injury network (AKIN) stage 3 and were treated by extended dialysis (ED). Twenty-eight day survival of all patients was 33%. While patients without ED showed a 28 day survival of 40%, the survival of patients with ED was only 19%. Patients on ED were not different in respect to age, weight, Horowitz index and underlying disease.
  
  
  CONCLUSIONS
  AKI requiring ED therapy in patients undergoing iLA treatment increases mortality in ICU patients. Patients in whom iLA was placed as a bridge to lung transplantation and that were successfully transplanted showed the best outcome. Future studies have to clarify whether it is possible to identify patients that truly benefit from the combination of these two extracorporeal treatment methods.
authors.affiliation: Department Nephrology and Hypertension, Medical School Hannover, Germany. kielstein@yahoo.com
authors.forename: Jan T
authors.initials: JT
authors.lastname: Kielstein
authors.forename: Soeren
authors.initials: S
authors.lastname: Tolk
authors.forename: Carsten
authors.initials: C
authors.lastname: Hafer
authors.forename: Anna
authors.initials: A
authors.lastname: Heiden
authors.forename: Olaf
authors.initials: O
authors.lastname: Wiesner
authors.forename: Christian
authors.initials: C
authors.lastname: Kühn
authors.forename: Johannes
authors.initials: J
authors.lastname: Hadem
authors.forename: Marius M
authors.initials: MM
authors.lastname: Hoeper
authors.forename: Stefan
authors.initials: S
authors.lastname: Fischer
mesh_terms: D058186:Acute Kidney Injury / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy*; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007362:Intensive Care Units; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D012122:Ventilators, Mechanical