title: Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma.
abstract: Background. The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors. Objective. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL). Methods. Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls. The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines. Results. Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls. All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression. AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13. Conclusions. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL.
authors.affiliation: Department of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA, CA 90095-1740, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Widney
authors.forename: Dorina
authors.initials: D
authors.lastname: Gui
authors.forename: Laura M
authors.initials: LM
authors.lastname: Popoviciu
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Said
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Breen
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.forename: Christina M R
authors.initials: CM
authors.lastname: Kitchen
authors.forename: Juan M
authors.initials: JM
authors.lastname: Alcantar
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Smith
authors.forename: Roger
authors.initials: R
authors.lastname: Detels
authors.forename: Otoniel
authors.initials: O
authors.lastname: Martínez-Maza