title: [Changes of soluble CD40 ligand in patients with hyperlipidemia of blood stasis syndrome and its clinical significance].
abstract: OBJECTIVE
  To observe changes of soluble CD40 ligand (sCD40L) in patients with hyperlipidemia of blood stasis syndrome and its correlation with blood stasis syndrome integral, P-selectin, and high sensitive creatine reactive protein (hs-CRP), to investigate the roles of platelet activation and inflammation in the physiopathologic process of blood-stasis type hyperlipidemia, and to explore the pathogenetic mechanism of blood-stasis syndrome (BSS).
  
  
  METHODS
  Seventy hyperlipidemia patients were assigned to two groups, 39 in the BSS group and 31 in the non-BSS group. Meanwhile, thirty healthy subjects were grouped as the control. Main physiochemical indices, blood levels of sCD40L, P-selectin, hs-CRP were detected in all. The correlations of the aforesaid indices were analyzed.
  
  
  RESULTS
  BSS score in the BSS group was higher than that in the non-BSS group and in the control group. Higher blood levels of P-selectin and sCD40L were shown in the BSS group than in the non-BSS group [(25.13 +/- 5.49) ng/L vs. (21.37 +/- 3.56) ng/L and (2.45 +/- 0.48) ng/L vs. (2.07 +/- 0. 41) ng/L] respectively, and the two indices were higher in hyperlipidemia patients than in healthy persons [(14.91 +/- 2.48) ng/L and (1.63 +/- 0.25) ng/L, P < 0.01]. Correlation analysis showed that in patients with hyperlipidemia, blood level of sCD40L was positively correlated with low-density lipoprotein cholesterol (LDL-C) level (r = 0.503, P < 0.01), P-selectin (r = 0.897, P < 0.01), and the BSS score (r = 0.603, P < 0.01).
  
  
  CONCLUSIONS
  The over-expressed sCD40L indicated persistent inflammatory state in patients with hyperlipidemia of BSS. BSS would further accelerate the chronic inflammation process of hyperlipidemia.
authors.affiliation: Department of Cardiovascular Diseases, Yueyang Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai. jinlu504@hotmail.com
authors.forename: Lu
authors.initials: L
authors.lastname: Jin
authors.forename: Li-ren
authors.initials: LR
authors.lastname: He
authors.forename: De-yu
authors.initials: DY
authors.lastname: Fu
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D023201:CD40 Ligand / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D007249:Inflammation / Q000097:blood; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood
chemical_list: D019007:P-Selectin; D023201:CD40 Ligand; D002097:C-Reactive Protein