title: CNS depressant activities of roots of Coccos nucifera in mice.
abstract: The ethanol extract of Coccos nucifera (EECN) was tested for possible pharmacological effects on experimental animals. EECN significantly potentiated the sleeping time of mice induced by standard hypnotics viz. pentobarbital sodium, diazepam, and meprobamate in a dose dependent manner. EECN showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. It also potentiated analgesia induced by morphine and pethidine in mice. Pretreatment with EECN caused significant protection against pentylenetetrazole-induced convulsions. The behavioral studies on mice indicate CNS depressant activity of the ethanol extract of C. nucifera.
authors.affiliation: College of Pharmacy, Institute of Foreign Trade & Management, Lodhipur Rajput, Delhi Road, Moradabad-244 001, U.P., India. drdilip71@gmail.com
authors.forename: Dilipkumar
authors.initials: D
authors.lastname: Pal
authors.forename: Abhijit
authors.initials: A
authors.lastname: Sarkar
authors.forename: Sumanta
authors.initials: S
authors.lastname: Gain
authors.forename: Sandip
authors.initials: S
authors.lastname: Jana
authors.forename: Soumit
authors.initials: S
authors.lastname: Mandal
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000494:pharmacology* / Q000633:toxicity; D003059:Cocos; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010433:Pentylenetetrazole; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D018517:Plant Roots; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects; D012997:Solvents / Q000737:chemistry
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D019342:Acetic Acid; D010433:Pentylenetetrazole