title: Opsoclonus-myoclonus and anti-Hu positive limbic encephalitis in a patient with neuroblastoma.
abstract: Opsoclonus-myoclonus syndrome (OMS) is seen in 2-3% of children with neuroblastoma and is believed to be caused by an autoimmune process elicited by the tumor. Although long-term neurologic sequelae are common in children with OMS, limbic encephalitis has not previously been reported. We report a child who developed limbic encephalitis associated with anti-Hu antibodies, 6 years after her initial diagnosis of neuroblastoma and OMS. This case demonstrates that patients with neuroblastoma and OMS are at risk for developing new paraneoplastic symptoms years after their original diagnosis and emphasizes the need for careful long-term follow-up.
authors.affiliation: Department of Pediatrics, University of Chicago, 900 E. 57th Street, Chicago, IL 60637, USA.
authors.forename: Andres
authors.initials: A
authors.lastname: Morales La Madrid
authors.forename: Charles M
authors.initials: CM
authors.lastname: Rubin
authors.forename: Michael
authors.initials: M
authors.lastname: Kohrman
authors.forename: Peter
authors.initials: P
authors.lastname: Pytel
authors.forename: Susan L
authors.initials: SL
authors.lastname: Cohn
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D020363:Limbic Encephalitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D009447:Neuroblastoma / Q000150:complications*; D053578:Opsoclonus-Myoclonus Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D010386:Pelvic Neoplasms / Q000150:complications*