title: Insights into the pathogenesis and treatment of cancer from inborn errors of metabolism.
abstract: Mutations in genes that play fundamental roles in metabolic pathways have been found to also play a role in tumor development and susceptibility to cancer. At the same time, significant progress has been made in the treatment of patients with inborn errors of metabolism (IEM),(1) resulting in increased longevity and the unmasking of cancer predisposition, frequently hepatocellular carcinoma, in these conditions. These patients offer a potential opportunity to deepen our understanding of how intermediary metabolism impacts tumorigenesis. We provide an overview from the perspective of cancers in patients affected with IEM and discuss how dysregulation of these specific metabolic pathways might contribute to the mechanisms of cancer development and treatment.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Ayelet
authors.initials: A
authors.lastname: Erez
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Shchelochkov
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Plon
authors.forename: Fernando
authors.initials: F
authors.lastname: Scaglia
authors.forename: Brendan
authors.initials: B
authors.lastname: Lee
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000209:etiology; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology; D008297:Male; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008661:Metabolism, Inborn Errors / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000628:therapy*
chemical_list: D004272:DNA, Mitochondrial