title: WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor.
abstract: Interleukin-21 (IL-21) is a pleiotropic cytokine that regulates T-cell, B-cell, NK-cell, and myeloid-cell functions. IL-21 binds with its cognate receptor complex, which consists of the IL-21 receptor (IL-21R) and the common gamma chain. We identified a novel IL-21R-binding molecule, WSB-1, which contains WD-40 repeats and a SOCS-box domain. WSB-1 associates with the middle part of intracytoplasmic region of IL-21R and enhances the maturation of IL-21R from N-linked glycosylated form to fully glycosylated mature form. Furthermore, WSB-1 moderates IL-21R degradation. Taken together, our present study suggests that WSB-1 has a role in the tuning of the maturation and degradation of IL-21R.
authors.affiliation: Department of Immunology, Yamagata University, Faculty of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Nara
authors.forename: Tadashi
authors.initials: T
authors.lastname: Onoda
authors.forename: Mizanur
authors.initials: M
authors.lastname: Rahman
authors.forename: Akemi
authors.initials: A
authors.lastname: Araki
authors.forename: Farha Matin
authors.initials: FM
authors.lastname: Juliana
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Hironobu
authors.initials: H
authors.lastname: Asao
mesh_terms: D002460:Cell Line; D003001:Cloning, Molecular; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006031:Glycosylation; D057809:HEK293 Cells; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D011485:Protein Binding; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D053655:Receptors, Interleukin-21 / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D012333:RNA, Messenger; D053655:Receptors, Interleukin-21; C120287:WSB1 protein, human