title: Translational/personalized medicine, pharmaco/surgico/radiogenomics, lymphatic spread of cancer, and medical ignoromes.
abstract: In the elusive quest for "personalized" cancer treatments based on pharmacogenomics, diverse challenges must be overcome: questionable validity of "molecular models of life," obstacles to bidirectional translation of scientific advances from bench to bedside to community, and limitations of bioinformatics to recognize and deal with "ignoramics/ignoromes" (expanding unknowns in cancer biology, theranostics, and therapeutic choices). These considerations apply to lymphatic system functioning-lymphatic vessels, lymph, lymph nodes, and lymphocytes-in diseases like cancer.
authors.affiliation: Department of Surgery, University of Arizona College of Medicine, Tucson, Arizona 85724-5200, USA. grace@surgery.arizona.edu
authors.forename: Marlys H
authors.initials: MH
authors.lastname: Witte
mesh_terms: D023281:Genomics; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000628:therapy*; D010597:Pharmacogenetics; D057285:Precision Medicine; D057170:Translational Research, Biomedical