title: Deoxynivalenol exposure assessment in a cohort of pregnant women from Bradford, UK.
abstract: Deoxynivalenol (DON) is a ubiquitous contaminant of cereal crops in temperate regions of the world. It causes growth faltering and immune suppression in animals. Limited information is available on DON exposure in UK subpopulations. The objective of this study was to provide DON exposure assessment in a subset of pregnant women scheduled for an elective caesarean in a large multi-ethnic mother/infant birth cohort from Bradford, UK. Women aged 16-44 years (n = 85) provided a urine sample for DON analysis in the last trimester of pregnancy, and concurrently completed a food-frequency questionnaire (FFQ). The urinary DON biomarker was detected in all measured samples (geometric mean (GM) = 10.3 ng DON mg(-1) creatinine, range = 0.5-116.7 ng mg(-1)). Levels were higher in women classified as South Asian in origin (GM: 15.2 ng mg(-1); 95% CI = 10.7-21.5 ng mg(-1)) compared with non-South Asians (GM = 8.6 ng mg(-1); 95% CI = 6.6-11.8 ng mg(-1)), p = 0.02). Estimated DON intake from FFQ data and typical levels of DON contamination of food suggest that this was mainly due to higher levels of exposure from bread, particularly daily intake of DON from chapattis in South Asians (estimated mean = 2.4 µg day(-1); 95% CI = 1.2, 3.7 µg day(-1)) compared with non-South Asians (estimated mean = 0.2 µg day(-1); 95% CI = 0-0.4 µg day(-1)), p < 0.001. This is the first biomarker demonstration of DON exposure in pregnant women, and several urinary DON levels were the highest ever recorded in any study. A larger survey within this birth cohort is warranted to investigate any potential risk to mothers and their babies, from DON exposure during pregnancy.
authors.affiliation: Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Hepworth
authors.forename: L J
authors.initials: LJ
authors.lastname: Hardie
authors.forename: L K
authors.initials: LK
authors.lastname: Fraser
authors.forename: V J
authors.initials: VJ
authors.lastname: Burley
authors.forename: R S
authors.initials: RS
authors.lastname: Mijal
authors.forename: C P
authors.initials: CP
authors.lastname: Wild
authors.forename: R
authors.initials: R
authors.lastname: Azad
authors.forename: P A
authors.initials: PA
authors.lastname: McKinney
authors.forename: P C
authors.initials: PC
authors.lastname: Turner
mesh_terms: D044466:Asian People; D015415:Biomarkers; D015331:Cohort Studies; D005247:Feeding Behavior; D005260:Female; D005506:Food Contamination; D006801:Humans; D011247:Pregnancy; D014255:Trichothecenes / Q000652:urine*; D006113:United Kingdom
chemical_list: D015415:Biomarkers; D014255:Trichothecenes; C007262:deoxynivalenol