title: Low-energy cranberry juice decreases lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome.
abstract: Cranberries, high in polyphenols, have been associated with several cardiovascular health benefits, although limited clinical trials have been reported to validate these findings. We tested the hypothesis that commercially available low-energy cranberry juice (Ocean Spray Cranberries, Inc, Lakeville-Middleboro, Mass) will decrease surrogate risk factors of cardiovascular disease, such as lipid oxidation, inflammation, and dyslipidemia, in subjects with metabolic syndrome. In a randomized, double-blind, placebo-controlled trial, participants identified with metabolic syndrome (n = 15-16/group) were assigned to 1 of 2 groups: cranberry juice (480 mL/day) or placebo (480 mL/day) for 8 weeks. Anthropometrics, blood pressure measurements, dietary analyses, and fasting blood draws were conducted at screen and 8 weeks of the study. Cranberry juice significantly increased plasma antioxidant capacity (1.5 ± 0.6 to 2.2 ± 0.4 μmol/L [means ± SD], P < .05) and decreased oxidized low-density lipoprotein and malondialdehyde (120.4 ± 31.0 to 80.4 ± 34.6 U/L and 3.4 ± 1.1 to 1.7 ± 0.7 μmol/L, respectively [means ± SD], P < .05) at 8 weeks vs placebo. However, cranberry juice consumption caused no significant improvements in blood pressure, glucose and lipid profiles, C-reactive protein, and interleukin-6. No changes in these parameters were noted in the placebo group. In conclusion, low-energy cranberry juice (2 cups/day) significantly reduces lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome.
authors.affiliation: Nutritional Sciences, 301 Human Environmental Sciences, Oklahoma State University, Stillwater, OK 74078-6141, USA. arpita.basu@okstate.edu
authors.forename: Arpita
authors.initials: A
authors.lastname: Basu
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Betts
authors.forename: Jennifer
authors.initials: J
authors.lastname: Ortiz
authors.forename: Brandi
authors.initials: B
authors.lastname: Simmons
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Wu
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Lyons
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000032:analysis; D001628:Beverages; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis; D004311:Double-Blind Method; D005260:Female; D005638:Fruit / Q000737:chemistry; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D024821:Metabolic Syndrome / Q000188:drug therapy*; D008875:Middle Aged; D008517:Phytotherapy; D012307:Risk Factors; D029799:Vaccinium macrocarpon / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D015850:Interleukin-6; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde; D002097:C-Reactive Protein