title: Proteins and renal fibrosis: low-protein diets induce Kruppel-like factor-15, limiting renal fibrosis.
abstract: The mechanisms underlying beneficial influences of low-protein diets on the progressive nature of chronic kidney disease are incompletely understood. Gao et al. identify a downregulation of Kruppel-like factor-15 (KLF15) associated with increased renal fibrosis. The KLF15 downregulation and renal fibrosis are reversed with dietary protein restriction, especially when ketoacids are added. The results suggest that KLF15 may play a role in suppressing renal fibrosis and could contribute to the benefits of dietary protein restriction.
authors.affiliation: Nephrology Division, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Wang
authors.forename: William E
authors.initials: WE
authors.lastname: Mitch
mesh_terms: D000818:Animals; D002908:Chronic Disease; D018753:Diet, Protein-Restricted; D005355:Fibrosis / Q000517:prevention & control; D007651:Keto Acids / Q000008:administration & dosage*; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000178:diet therapy*; D051741:Kruppel-Like Transcription Factors / Q000502:physiology*; D051381:Rats
chemical_list: D007651:Keto Acids; C520013:Klf15 protein, rat; D051741:Kruppel-Like Transcription Factors