title: New acrylamide and oxazolidin derivatives from a termite-associated Streptomyces sp.
abstract: Two new compounds, named 2-formylpyrrole-4-acrylamide (1) and dihydrostreptazolin (2) were isolated from the fermentation broth of BY-4, an actinomycetes residing in the gut of Odontotermes formosanus. The structures of 1 and 2 were elucidated by extensive spectral analysis (1H, 13C, 2D NMR, and HR-ESIMS). The isolated compounds were assayed for cytotoxic and antimicrobial activities.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 210093 Nanjing, PR China.
authors.forename: Shu Feng
authors.initials: SF
authors.lastname: Bi
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Yong Chun
authors.initials: YC
authors.lastname: Song
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
mesh_terms: D000178:Acrylamides / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D020049:Isoptera / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry*
chemical_list: C558324:2-formylpyrrole-4-acrylamide; D000178:Acrylamides; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D010080:Oxazoles; D010880:Piperidines; D011758:Pyrroles; C558325:dihydrostreptazolin