title: Long-term stability of surgical bone regenerative procedures of peri-implantitis lesions in a prospective case-control study over 3 years.
abstract: OBJECTIVE
  To evaluate the extent of bone fill over 3 years following the surgical treatment of peri-implantitis with bone grafting with or without a membrane.
  
  
  METHODS
  In a non-submerged wound-healing mode, 15 subjects with 27 implants were treated with a bone substitute (Algipore(®)) alone and 17 subjects with 29 implants were treated with the bone substitute and a resorbable membrane (Osseoquest(®)). Implants with radiographic bone loss ≥1.8 mm following the first year in function and with bleeding and/or pus on probing were included. Following surgery, subjects were given systemic antibiotics (10 days) and rinsed with chlorhexidine. After initial healing, the subjects were enrolled in a strict maintenance programme.
  
  
  RESULTS
  Statistical analysis failed to demonstrate changes in bone fill between 1 and 3 years both between and within procedure groups. The mean defect fill at 3 years was 1.3 ± (SD) 1.3 mm if treated with the bone substitute alone and 1.6 ± (SD) 1.2 mm if treated with an adjunct resorbable membrane, (p=0.40). The plaque index decreased from approximately 40-10%, remaining stable during the following 2 years.
  
  
  CONCLUSIONS
  Defect fill using a bone substitute with or without a membrane technique in the treatment of peri-implantitis can be maintained over 3 years.
authors.affiliation: Department of Periodontology, Public Dental Health Service, Kristianstad, Sweden.
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Roos-Jansåker
authors.forename: Christel
authors.initials: C
authors.lastname: Lindahl
authors.forename: G Rutger
authors.initials: GR
authors.lastname: Persson
authors.forename: Stefan
authors.initials: S
authors.lastname: Renvert
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D001861:Bone Regeneration; D018786:Bone Substitutes; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D057873:Peri-Implantitis / Q000601:surgery*; D011446:Prospective Studies; D011859:Radiography; D055502:Secondary Prevention; D016037:Single-Blind Method; D018709:Statistics, Nonparametric
chemical_list: C483718:Algipore; D018786:Bone Substitutes; D008567:Membranes, Artificial