title: Total asymmetric synthesis of monosaccharides and analogues.
abstract: Since the discovery of the 'formose reaction' by Butlerow, total synthesis of carbohydrates has undergone rapid development. The most important methods for the asymmetric synthesis of monosaccharides and analogues of biological importance are presented. Nowadays any natural and non-natural monosaccharide can be prepared pure in both enantiomeric forms starting from inexpensive starting materials. Metal-based asymmetric catalysis and organocatalysis have been successfully applied, alone or in combination with chemoenzymatic methods. Alternative methods rely upon substrate- or reagent-controlled diastereo- and enantioselective reactions. Suitably protected carbohydrates have been prepared by total synthesis, thus allowing their direct use in the preparation of oligosaccharides and analogues.
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Prof. Garcia González, Spain. robina@us.es
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Robina
authors.forename: Ana T
authors.initials: AT
authors.lastname: Carmona
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Moreno-Vargas
authors.forename: Elena
authors.initials: E
authors.lastname: Moreno-Clavijo
mesh_terms: D015394:Molecular Structure; D009005:Monosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D009005:Monosaccharides