title: FLNA and PGK1 are two potential markers for progression in hepatocellular carcinoma.
abstract: OBJECTIVE
  Hepatocellular carcinoma (HCC) is one of the most deadly diseases; metastasis and recurrence are the most important factors that affect the therapy of HCC chronically. Until now, the prognosis for the metastasis of HCC had not improved. Recently, several proteins that are related to metastasis and invasion of HCC were identified, but the effective markers still remain to be elucidated.
  
  
  METHODS
  In this study, comparative proteomics was used to study the differentially expressed proteins in two HCC cell lines MHCC97L and HCCLM9, which have low and high metastatic potentials, respectively.
  
  
  RESULTS
  Our findings indicated that filamin A (FLNA) and phosphoglycerate kinase 1 (PGK1) were two significantly differentially expressed proteins, with high expression in HCCLM9 cells, and may influence the metastasis of HCC cells.
  
  
  CONCLUSIONS
  Taken together with the confirmation of expression on the mRNA level, we propose the use of FLNA and PGK1 as potential markers for the progression of HCC.
authors.affiliation: Core Facility of Genetically Engineered Mice, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Ai
authors.forename: Huizhe
authors.initials: H
authors.lastname: Huang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lv
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Tang
authors.forename: Mianzhi
authors.initials: M
authors.lastname: Chen
authors.forename: Tielin
authors.initials: T
authors.lastname: Chen
authors.forename: Weiwei
authors.initials: W
authors.lastname: Duan
authors.forename: Huan
authors.initials: H
authors.lastname: Sun
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Li
authors.forename: Ruizhi
authors.initials: R
authors.lastname: Tan
authors.forename: Yuhang
authors.initials: Y
authors.lastname: Liu
authors.forename: Jingjing
authors.initials: J
authors.lastname: Duan
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Wei
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D003285:Contractile Proteins / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D004591:Electrophoresis, Polyacrylamide Gel; D064448:Filamins; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D010735:Phosphoglycerate Kinase / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D014357:Trypsin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D003285:Contractile Proteins; D064448:Filamins; D008840:Microfilament Proteins; D012333:RNA, Messenger; D010735:Phosphoglycerate Kinase; D014357:Trypsin