title: Reconsidering recent myocardial infarction as a contraindication for IV stroke thrombolysis.
abstract: OBJECTIVE
  We reviewed the literature on IV stroke thrombolysis for patients with recent myocardial infarction (MI).
  
  
  METHODS
  We searched PubMed and Ovid databases, relevant trials, and guidelines.
  
  
  RESULTS
  Only 5 thrombolyzed stroke patients with recent MI were reported to have cardiac tamponade. Pathological studies show MI healing is completed by 7 weeks.
  
  
  CONCLUSIONS
  The time window from MI as a contraindication for IV stroke thrombolysis may be narrowed from 3 months in current guidelines to 7 weeks.
authors.affiliation: Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608. gnrdsd@sgh.com.sg
authors.forename: D A
authors.initials: DA
authors.lastname: De Silva
authors.forename: J J F
authors.initials: JJ
authors.lastname: Manzano
authors.forename: H M
authors.initials: HM
authors.lastname: Chang
authors.forename: M C
authors.initials: MC
authors.lastname: Wong
mesh_terms: D002986:Clinical Trials as Topic; D000075202:Contraindications; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D017408:Guidelines as Topic; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications*; D039781:PubMed; D012307:Risk Factors; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents