title: Effect of aspirin pre- and postburn on survival of experimental intermediate burns in rats.
abstract: BACKGROUND
  Burns are a major health care problem. Early treatment increases survival of intermediate burn zones, thus decreasing morbidity, mortality, surgery, and hospitalization. Previously, aspirin was shown to improve burn perfusion and increase failing flap survival.
  
  
  OBJECTIVE
  Owing to similarities between failing flaps and intermediate burn zones, we conducted this study to evaluate the effect of aspirin on intermediate burn zone survival.
  
  
  METHODS
  An intermediate burn was created in 30 rats randomly divided into three experimental groups: pre- and postburn aspirin groups and a control group. Final burn survival was evaluated on day 7.
  
  
  RESULTS
  No statistical difference was observed between the test and control groups. Both aspirin regimens failed to improve intermediate burn survival.
  
  
  CONCLUSIONS
  Presumably, administration of aspirin could not prevent the noxious tissue events of burn injury that cause cell death. Possibly, different dosages or modes of administering aspirin could have a beneficial effect on burn wound survival.
authors.affiliation: Department of Plastic Sugery, Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Hadad
authors.forename: Melvyn
authors.initials: M
authors.lastname: Westreich
authors.forename: Tal
authors.initials: T
authors.lastname: Friedman
authors.forename: Avshalom
authors.initials: A
authors.lastname: Shalom
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D002056:Burns / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000293:injuries*; D014022:Tissue Survival / Q000187:drug effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin