title: Common molecular cytogenetic pathway in papillary tumors of the pineal region (PTPR).
abstract: Primary papillary tumors of the central nervous system and particularly the pineal region are rare. Papillary tumor of the pineal region (PTPR) is a recently described neoplasm that has been formally recognized in the 2007 World Health Organization Classification of Tumors of the Nervous System. Because of their rarity, further pheno- and genotypical observations as well as therapeutic experience are necessary to differentiate PTPR from other primary or secondary papillary tumors of this region. We herein present three cases of PTPR characterized by local recurrence in two of them. Primary and recurrent tumors were analyzed by immunohistochemistry and comparative genomic hybridization (CGH). From our results clonal chromosomal aberrations can be postulated which seem to be a feasible tool to differentiate PTPRs from other primary or secondary papillary tumors of this region.
authors.affiliation: Departments of Neurosurgery Pathology, Georg August University Göttingen, Germany. agutenberg@med.uni-goettingen.de
authors.forename: Angelika
authors.initials: A
authors.lastname: Gutenberg
authors.forename: Almuth
authors.initials: A
authors.lastname: Brandis
authors.forename: Bujung
authors.initials: B
authors.lastname: Hong
authors.forename: Bastian
authors.initials: B
authors.lastname: Gunawan
authors.forename: Christina
authors.initials: C
authors.lastname: Enders
authors.forename: Inga-Marie
authors.initials: IM
authors.lastname: Schaefer
authors.forename: Ralf
authors.initials: R
authors.lastname: Burger
authors.forename: Helmut
authors.initials: H
authors.lastname: Ostertag
authors.forename: Michael
authors.initials: M
authors.lastname: Gaab
authors.forename: Joachim K
authors.initials: JK
authors.lastname: Krauss
authors.forename: Laszlo
authors.initials: L
authors.lastname: Füzesi
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D055028:Comparative Genomic Hybridization; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology; D019635:Neurosurgical Procedures; D010870:Pineal Gland / Q000473:pathology*; D010871:Pinealoma / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D011878:Radiotherapy