title: Anterior craniofacial resection for malignant paranasal tumors: a monoinstitutional experience of 366 cases.
abstract: BACKGROUND
  The purpose of this study was to evaluate the results of a mono-institutional series of patients treated with anterior craniofacial resection for malignant paranasal sinus tumors.
  
  
  METHODS
  We analyzed all patients with malignant paranasal sinus tumors treated with anterior craniofacial resection at our institution between 1987 and 2007. All tumors were classified according to both the American Joint Committee on Cancer (AJCC)-2002 and the Istituto Nazionale Tumori (INT) classifications.
  
  
  RESULTS
  The sample included 366 patients. There was intraorbital spread in 108 cases. The skull base was eroded in 127 patients, with dura or brain involvement in 93 patients. The 10-year disease-specific survival was 53.1%. Histologic subtype, INT stage, surgical margins, and postsurgical radiotherapy were significant, independent predictors for both local relapse and disease-specific survival (DSS). The AJCC-2002 classification was not significant when tested in place of INT stage.
  
  
  CONCLUSIONS
  Our data indicated that craniofacial resection and postsurgical radiotherapy remain the primary option for malignant tumors involving the anterior skull base.
authors.affiliation: Cranio-Maxillo-Facial Unit, Fondazione I.R.C.C.S. Istituto Nazionale dei Tumori, Milano, Italy. gcantu43@gmail.com
authors.forename: Giulio
authors.initials: G
authors.lastname: Cantu
authors.forename: Carlo L
authors.initials: CL
authors.lastname: Solero
authors.forename: Rosalba
authors.initials: R
authors.lastname: Miceli
authors.forename: Flavia
authors.initials: F
authors.lastname: Mattana
authors.forename: Stefano
authors.initials: S
authors.lastname: Riccio
authors.forename: Sarah
authors.initials: S
authors.lastname: Colombo
authors.forename: Madia
authors.initials: M
authors.lastname: Pompilio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lombardo
authors.forename: Paolo
authors.initials: P
authors.lastname: Formillo
authors.forename: Pasquale
authors.initials: P
authors.lastname: Quattrone
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D005145:Face / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D012886:Skull / Q000601:surgery; D019292:Skull Base Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D016019:Survival Analysis