title: Aromatase and its inhibition in behaviour, obsessive compulsive disorder and parkinsonism.
abstract: Oestrogens regulate normal behaviour and have been implicated in modulating pathological behaviour such as obsessive compulsive disorder and neurological disorder such as Parkinsonism. Therefore, by regulating the expression of the oestrogen-synthesising enzyme, aromatase, we may identify what behaviour is regulated by oestrogen. Inhibition of aromatase either genetically or pharmacologically has been reported to induce sexual behaviour impairment, compulsive behaviour and susceptibility to neurodegeneration.
authors.affiliation: Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria 3010, Australia. wah.chin.boon@florey.edu.au
authors.forename: Wah Chin
authors.initials: WC
authors.lastname: Boon
authors.forename: Malcolm K
authors.initials: MK
authors.lastname: Horne
mesh_terms: D000818:Animals; D001141:Aromatase / Q000235:genetics / Q000378:metabolism*; D047072:Aromatase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D004967:Estrogens / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007858:Learning / Q000187:drug effects; D051379:Mice; D018345:Mice, Knockout; D009771:Obsessive-Compulsive Disorder / Q000139:chemically induced* / Q000201:enzymology; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000201:enzymology; D012726:Sexual Behavior, Animal / Q000187:drug effects
chemical_list: D047072:Aromatase Inhibitors; D004967:Estrogens; D001141:Aromatase