title: Subepithelial connective tissue graft for treatment of gingival recessions with and without enamel matrix derivative: a multicenter, randomized controlled clinical trial.
abstract: The aim of this multicenter, randomized controlled trial was to compare the clinical outcomes of a connective tissue graft (CTG) alone or in combination with enamel matrix derivative (CTG + EMD) in the treatment of Miller Class I and II gingival recessions. The 56 selected defects were evaluated for probing depth, recession depth, keratinized tissue width, and probing attachment level, and were measured at baseline and 12 months after treatment. The mean recession reduction was 3.9 ± 0.8 mm for EMD-treated sites (test) and 3.6 ± 1.5 mm for the control group (P = .22), corresponding to a mean root coverage of 90% and 80% for test and control groups, respectively (P = .05). Complete root coverage was obtained in 62% of test sites compared to 47% in the control group (P = .27). Both procedures provided good soft tissue coverage. The better results of the test group did not achieve a statistically significant level.
authors.affiliation: Unit of Peridontology, Department of Surgical, Reconstructive and Diagnostic Science, University of Milan, IRCCS Cà Grande Policlinico, Milan, Italy. giulio@studiorasperini.it
authors.forename: Giulio
authors.initials: G
authors.lastname: Rasperini
authors.forename: Mario
authors.initials: M
authors.lastname: Roccuzzo
authors.forename: Luca
authors.initials: L
authors.lastname: Francetti
authors.forename: Raffaele
authors.initials: R
authors.lastname: Acunzo
authors.forename: Dario
authors.initials: D
authors.lastname: Consonni
authors.forename: Maurizio
authors.initials: M
authors.lastname: Silvestri
mesh_terms: D000328:Adult; D003238:Connective Tissue / Q000637:transplantation; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000473:pathology / Q000637:transplantation*; D005889:Gingival Recession / Q000145:classification / Q000601:surgery*; D006801:Humans; D007633:Keratins; D008297:Male; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D013524:Surgical Flaps; D019237:Tooth Cervix / Q000473:pathology / Q000601:surgery; D014092:Tooth Root / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins; D007633:Keratins