title: [Hormonal control of pituitary adenomas by transsphenoidal surgery: results of the first five years of experience].
abstract: OBJECTIVE
  To evaluate the initial results of a surgical team in the hormonal control of secreting pituitary adenomas.
  
  
  METHODS
  In five years 51 functioning adenomas were operated (31 GH-secreting, 14 ACTH-secreting, 5 PRL-secreting and 1 TSH-secreting). Hormonal control was defined as GH < 2,5 ng/mL, normal free-urinary cortisol, lower prolactin and normal T3 and FT4.
  
  
  RESULTS
  Control rates were 36% in acromegaly, and 57% in Cushing's disease. Two prolactinomas normalized prolactin levels. Thyroid hormone levels were normalized in the TSH-secreting adenoma. Control of hypercortisolism was positively correlated with years of experience (p = 0.01).
  
  
  CONCLUSIONS
  Our results, although restricted to the beginning of our experience, lie below the reported range of other surgical series with much longer experience. During these years, there was a significant improvement in initial post surgery urinary cortisol levels in Cushing's disease as a function of surgical experience.
authors.affiliation: Disciplina de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Erika Ribeiro
authors.initials: ER
authors.lastname: Barbosa
authors.forename: Samuel Tau
authors.initials: ST
authors.lastname: Zymberg
authors.forename: Rodrigo de Paula
authors.initials: Rde P
authors.lastname: Santos
authors.forename: Helio Rubens
authors.initials: HR
authors.lastname: Machado
authors.forename: Julio
authors.initials: J
authors.lastname: Abucham
mesh_terms: D000172:Acromegaly / Q000097:blood; D000328:Adult; D000368:Aged; D003480:Cushing Syndrome / Q000097:blood / Q000652:urine; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D007016:Hypophysectomy / Q000379:methods*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010907:Pituitary Hormones / Q000097:blood; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D015175:Prolactinoma / Q000097:blood / Q000601:surgery; D018709:Statistics, Nonparametric; D013972:Thyrotropin / Q000097:blood; D013997:Time Factors; D055815:Young Adult
chemical_list: D010907:Pituitary Hormones; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013972:Thyrotropin; D006854:Hydrocortisone