title: Multifocal electroretinogram and optical coherent tomography: prediction of visual outcome after epiretinal membrane removal.
abstract: OBJECTIVE
  The aim was to evaluate the value of multifocal electroretinogram (mfERG) and optical coherence tomography (OCT) in predicting post-operative visual acuity (post-VA) after removal of an idiopathic epiretinal membrane (ERM).
  
  
  METHODS
  Fifty-one eyes of 51 patients with an idiopathic macular ERM were examined by OCT and mfERG before three-port pars plana vitrectomy with removal of the ERM. The parameters of the OCT images and mfERGs, pre-operative visual acuity (pre-VA) and the duration of symptoms (DS) were compared with the post-VA.
  
  
  RESULTS
  The pre-VA (r = 0.570, p < 0.001) and the duration of the symptoms (r = 0.389, p < 0.035; n = 35) were significantly correlated with the post-VA. The central retinal thickness (CRT) was significantly correlated with the pre-VA (r = 0.379, p < 0.01) and the post-VA (r = 0.318, p < 0.03). The amplitudes of macular electroretinogram (amERGs) were not significantly correlated with the pre-VA or post-VA. The CRT to amERG ratio (CRT/amERG) was correlated with the post-VA (r = 0.429, p < 0.002) but not with the pre-VA (p > 0.1). Comparative analyses among groups of cases based on CRT/amERG showed significant differences in the post-VA but not in the pre-VA and the duration of symptoms.
  
  
  CONCLUSIONS
  As with the large CRT/amERG, the pre-operative morphologically thickened and electroretinographically reduced retinas have a greater likelihood of being affected by the irreversible photoreceptor damages that could have been masked or modified by other factors before the removal of the ERM. Because the CRT/amERG values are obtained objectively, they should be valuable in predicting the post-operative visual function along with the pre-VA and the duration of symptoms.
authors.affiliation: Department of Ophthalmology, Fujita Health University Banbuntane Hotokukai Hospital, Aichi, Japan Department of Ophthalmology, Fujita Health University School of Medicine, Aichi, Japan. ysmd@za2.so-net.ne.jp
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Shimada
authors.forename: Shizuka
authors.initials: S
authors.lastname: Sakurai
authors.forename: Kousaku
authors.initials: K
authors.lastname: Naito
authors.forename: Taro
authors.initials: T
authors.lastname: Sugino
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kojima
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Hori
authors.forename: Masayuki
authors.initials: M
authors.lastname: Horiguchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004596:Electroretinography / Q000379:methods*; D019773:Epiretinal Membrane / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome; D014792:Visual Acuity