title: Microwave beamforming for non-invasive patient-specific hyperthermia treatment of pediatric brain cancer.
abstract: We present a numerical study of an array-based microwave beamforming approach for non-invasive hyperthermia treatment of pediatric brain tumors. The transmit beamformer is designed to achieve localized heating-that is, to achieve constructive interference and selective absorption of the transmitted electromagnetic waves at the desired focus location in the brain while achieving destructive interference elsewhere. The design process takes into account patient-specific and target-specific propagation characteristics at 1 GHz. We evaluate the effectiveness of the beamforming approach using finite-difference time-domain simulations of two MRI-derived child head models from the Virtual Family (IT'IS Foundation). Microwave power deposition and the resulting steady-state thermal distribution are calculated for each of several randomly chosen focus locations. We also explore the robustness of the design to mismatch between the assumed and actual dielectric properties of the patient. Lastly, we demonstrate the ability of the beamformer to suppress hot spots caused by pockets of cerebrospinal fluid (CSF) in the brain. Our results show that microwave beamforming has the potential to create localized heating zones in the head models for focus locations that are not surrounded by large amounts of CSF. These promising results suggest that the technique warrants further investigation and development.
authors.affiliation: Department of Electrical and Computer Engineering, University of Wisconsin-Madison, WI, USA. bmatthew@wisc.edu
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Burfeindt
authors.forename: Earl
authors.initials: E
authors.lastname: Zastrow
authors.forename: Susan C
authors.initials: SC
authors.lastname: Hagness
authors.forename: Barry D
authors.initials: BD
authors.lastname: Van Veen
authors.forename: Joshua E
authors.initials: JE
authors.lastname: Medow
mesh_terms: D001921:Brain / Q000528:radiation effects; D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D019047:Phantoms, Imaging; D057285:Precision Medicine / Q000379:methods*