title: CXCL10 expressing hematopoietic-derived cells are requisite in defense against HSV-1 infection in the nervous system of CXCL10 deficient mice.
abstract: The chemokine CXCL10 is crucial for the control of viral replication through the regulation of mobilization of antigen-specific T cells to sites of infection. CXCL10 is highly expressed both at sites of inflammation as well as constitutively within lymphoid organs by both bone marrow (BM)-derived and non-BM-derived cells. However, the relative immunologic importance of CXCL10 expressed by these divergent sources relative to HSV-1 infection is unknown. Using mouse chimeras reconstituted with either wild type or CXCL10 deficient mouse BM, we show BM-derived, radiation-sensitive cells from wild type mice were solely responsible for resistance to HSV-1 in the trigeminal ganglia and brain stem. The resistance was not reflected by a deficiency in the recruitment of effector cells to sites of inflammation or expression of chemokines or IFN-gamma and likely results from additional, yet-to-be-determined factors emanating from wild type, BM-derived cells.
authors.affiliation: Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
authors.forename: Todd R
authors.initials: TR
authors.lastname: Wuest
authors.forename: Manoj
authors.initials: M
authors.lastname: Thapa
authors.forename: Min
authors.initials: M
authors.lastname: Zheng
authors.forename: Daniel J J
authors.initials: DJ
authors.lastname: Carr
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000378:metabolism / Q000473:pathology / Q000821:virology; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000172:deficiency*; D018925:Chemokines / Q000378:metabolism; D004195:Disease Models, Animal; D005434:Flow Cytometry / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006561:Herpes Simplex / Q000473:pathology* / Q000601:surgery; D018259:Herpesvirus 1, Human; D007694:Killer Cells, Natural / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012668:Trigeminal Ganglion / Q000378:metabolism / Q000473:pathology / Q000821:virology
chemical_list: D054357:Chemokine CXCL10; D018925:Chemokines; C485433:Cxcl10 protein, mouse