title: Genotoxicity investigation of ELF-magnetic fields in Salmonella typhimurium with the sensitive SOS-based VITOTOX test.
abstract: We performed a genotoxicity investigation of extremely low-frequency (ELF) magnetic fields (MFs, 50 Hz, 100 and 500 µT, 1 and 2 h exposure) alone and in combination with known chemical mutagens using the VITOTOX test. This test is a very sensitive reporter assay of Salmonella typhimurium bacteria based on the SOS response. Our study showed that ELF-MFs do not induce SOS-based mutagenicity in S. typhimurium bacteria and do not show any synergetic effect when combined with chemical mutagens.
authors.affiliation: Laboratory of Toxicology, O.D. Public Health and Surveillance, Scientific Institute of Public Health, Brussels, Belgium. luc.verschaeve@wiv-isp.be
authors.forename: Luc
authors.initials: L
authors.lastname: Verschaeve
authors.forename: Roel
authors.initials: R
authors.lastname: Anthonissen
authors.forename: Magda
authors.initials: M
authors.lastname: Grudniewska
authors.forename: Jakub
authors.initials: J
authors.lastname: Wudarski
authors.forename: Lieven
authors.initials: L
authors.lastname: Gevaert
authors.forename: Annemarie
authors.initials: A
authors.lastname: Maes
mesh_terms: D004249:DNA Damage; D060526:Magnetic Fields / Q000009:adverse effects*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000008:administration & dosage*; D013014:SOS Response, Genetics / Q000528:radiation effects*; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects*; D012680:Sensitivity and Specificity
chemical_list: D009153:Mutagens