title: Combined treatment of uveal melanoma liver metastases.
abstract: Uveal melanoma (UM) is the most prevalent intraocular malignant tumor in the Western world. The prognosis of survival in the presence of metastatic disease is 2-7 months, depending on the treatment applied. - This article presents a case of metastatic UM with successful complex treatment of liver metastases. - A 49-year old female, underwent removal of the right eyeball in 1996 due to a histologically confirmed uveal melanoma. After 11 years, CT revealed a mass in the left kidney and multiple metastases in the liver. After left nephrectomy, 6 chemotherapy courses with dacarbazine were performed. The increasing liver metastases were observed. Additional 4 intraarterial (i/a) chemotherapy courses were administered using cisplatin, doxorubicin, fluorouracil, and interferon alfa. After few courses increase in CTC Grade 4 liver transaminases was seen. A partial response was observed, and in December 2008 the patient underwent surgery removing all liver metastases by 7 wedge or atypical resections. All margins were tumor-free. 21 months after liver resections and 14 years since dia?gnosis, the patient is alive without evidence of disease. - Successful treatment of metastatic uveal melanoma was due to a timely application of a combination of several treatment methods and good prognostic factors of the patient.
authors.affiliation: Centre of Hematology, Oncology and Transfusion Medicine, Vilnius University Hospital Santariskiu Clinics, Santariskiu 2, LT-08661, Vilnius, Lithuania. birute.brasiuniene@santa.lt
authors.forename: Birute
authors.initials: B
authors.lastname: Brasiuniene
authors.forename: V
authors.initials: V
authors.lastname: Sokolovas
authors.forename: V
authors.initials: V
authors.lastname: Brasiunas
authors.forename: A
authors.initials: A
authors.lastname: Barakauskiene
authors.forename: K
authors.initials: K
authors.lastname: Strupas
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007680:Kidney Neoplasms / Q000556:secondary / Q000601:surgery; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery*; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D009392:Nephrectomy; D011379:Prognosis; D014057:Tomography, X-Ray Computed; D014604:Uveal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D000098943:Uveal Melanoma