title: Drinking water fluoride and blood pressure? An environmental study.
abstract: The relationship between intakes of fluoride (F) from drinking water and blood pressure has not yet been reported. We examined the relationship of F in ground water resources (GWRs) of Iran with the blood pressure of Iranian population in an ecologic study. The mean F data of the GWRs (as a surrogate for F levels in drinking water) were derived from a previously conducted study. The hypertension prevalence and the mean of systolic and diastolic blood pressures (SBP & DBP) of Iranian population by different provinces and genders were also derived from the provincial report of non-communicable disease risk factor surveillance of Iran. Statistically significant positive correlations were found between the mean concentrations of F in the GWRs and the hypertension prevalence of males (r = 0.48, p = 0.007), females (r = 0.36, p = 0.048), and overall (r = 0.495, p = 0.005). Also, statistically significant positive correlations between the mean concentrations of F in the GWRs and the mean SBP of males (r = 0.431, p = 0.018), and a borderline correlation with females (r = 0.352, p = 0.057) were found. In conclusion, we found the increase of hypertension prevalence and the SBP mean with the increase of F level in the GWRs of Iranian population.
authors.affiliation: Department of Environmental Health Engineering, Tehran University of Medical Sciences, Qods Street, PO Box 14155-6446, Tehran, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Amini
authors.forename: Seyed Mahmood
authors.initials: SM
authors.lastname: Taghavi Shahri
authors.forename: Mohamad
authors.initials: M
authors.lastname: Amini
authors.forename: Majid
authors.initials: M
authors.lastname: Ramezani Mehrian
authors.forename: Yaser
authors.initials: Y
authors.lastname: Mokhayeri
authors.forename: Masud
authors.initials: M
authors.lastname: Yunesian
mesh_terms: D001794:Blood Pressure / Q000187:drug effects*; D002648:Child; D060766:Drinking Water / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D062665:Epidemiological Monitoring; D005260:Female; D005457:Fluoridation / Q000009:adverse effects*; D005459:Fluorides / Q000032:analysis*; D005843:Geography; D060587:Groundwater / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000453:epidemiology; D007492:Iran / Q000453:epidemiology; D008297:Male; D011159:Population Surveillance; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D060766:Drinking Water; D005459:Fluorides