title: [Modification of seaweed polysaccharide-agarose and its application as skin dressing (III)--skin regeneration with agarose grafting hyaluronic acid sponge].
abstract: In this paper, a kind of skin dressing, agarose- grafting- hyaluronic acid (Ag-g-HA) sponge was applied to test the modified agarose based scaffold for skin regeneration. The bFGF loading agarose-grafting hyaluronan scaffold had homogenous porosities, and the loaded bFGF was bioactive in 2 weeks. The Ag-g-HA sponge was applied into skin of mice, and it was found that the dressing promoted skin regeneration and no infection and leakage in lesion site took place. H&E staining results showed that the repaired skin was similar to autologous skin. These demonstrate that Ag-g-HA sponge has a promise in skin regeneration.
authors.affiliation: Biomedical Engineering Institute, Jinan University, Guangzhou 510632, China.
authors.forename: Jianyan
authors.initials: J
authors.lastname: Huang
authors.forename: Lingmin
authors.initials: L
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Chu
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Shunqing
authors.initials: S
authors.lastname: Tang
mesh_terms: D000818:Animals; D001458:Bandages; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000502:physiology; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use; D011897:Random Allocation; D012624:Seaweed / Q000737:chemistry; D012685:Sepharose / Q000302:isolation & purification / Q000627:therapeutic use*; D015503:Surgical Sponges; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D011134:Polysaccharides; D016222:Fibroblast Growth Factor 2; D006820:Hyaluronic Acid; D012685:Sepharose