title: Does Kaposi's sarcoma predict multicentric Castleman disease in the presence of generalized lymphadenopathy?
abstract: Multisystemic Castleman disease (MCD) can be associated with HHV8 infection, which involves the mantle zone of follicles. This condition results in an increase number of HHV8-positive (HHV8+) plasmablasts that multiply and amalgamate to form plasmablastic B-cell lymphoma. All previously reported cases of HIV-positive patients with MCD were coinfected with HHV8. Twelve cases of HIV- MCD that are HHV8+ were encountered in the literature, three of them developed lymphoma, and none of those cases were reported to have Kaposi's sarcoma (KS). We report a unique case of HIV-negative elderly woman with preexisting KS that presented to the hospital with recurring nausea, vomiting, and fever, assessment revealed diffuse lymphadenopathy. Axillary lymph node biopsy showed HHV8+ MCD with foci of microlymphoma. Despite the treatment with high-dose steroids, she developed multisystem failure that lead to her death.
authors.affiliation: Staten Island University Hospital, 475 Seaview Ave, Staten Island, NY 10305, USA. homam.md11@yahoo.com
authors.forename: Homam
authors.initials: H
authors.lastname: Alkaied
authors.forename: Kassem
authors.initials: K
authors.lastname: Harris
authors.forename: Dany
authors.initials: D
authors.lastname: Elsayegh
authors.forename: Inga
authors.initials: I
authors.lastname: Khachaturova
authors.forename: Michael
authors.initials: M
authors.lastname: Awasum
authors.forename: Seema
authors.initials: S
authors.lastname: Varma
mesh_terms: D000368:Aged; D005871:Castleman Disease / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D005260:Female; D019288:Herpesvirus 8, Human / Q000472:pathogenicity*; D006801:Humans; D008206:Lymphatic Diseases / Q000150:complications* / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000473:pathology