title: The application of nanoparticles in gene therapy and magnetic resonance imaging.
abstract: The combination of nanoparticles, gene therapy, and medical imaging has given rise to a new field known as gene theranostics, in which a nanobioconjugate is used to diagnose and treat the disease. The process generally involves binding between a vector carrying the genetic information and a nanoparticle, which provides the signal for imaging. The synthesis of this probe generates a synergic effect, enhancing the efficiency of gene transduction and imaging contrast. We discuss the latest approaches in the synthesis of nanoparticles for magnetic resonance imaging, gene therapy strategies, and their conjugation and in vivo application.
authors.affiliation: Facultad de Farmacia, Departamento de Química Física II, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Herranz
authors.forename: Elena
authors.initials: E
authors.lastname: Almarza
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodríguez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Salinas
authors.forename: Yamilka
authors.initials: Y
authors.lastname: Rosell
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
authors.forename: Jeff W
authors.initials: JW
authors.lastname: Bulte
authors.forename: Jesús
authors.initials: J
authors.lastname: Ruiz-Cabello
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D046529:Microscopy, Electron, Transmission; D058726:Nanoconjugates / Q000737:chemistry*; D051381:Rats
chemical_list: D058726:Nanoconjugates