title: [Congenital acute monoblastic leukemia: about one case and differential diagnosis].
abstract: Congenital leukemia is a rare disease in the newborns. It poses, however, many problems both for the clinician and for the biologist. Although of unknown etiology, the development of neonatal acute leukemia suggests a chromosomal rearrangement. Several specific chromosome rearrangements, common in cases of congenital leukemia, have been identified; it implies frequently the MLL gene. The differential diagnosis is difficult and includes different diseases frequently found in the neonatal period. We report the case of a newborn developing acute monocytic leukemia one hour after birth. Cytogenetics revealed a rearrangement of the MLL gene. The child was treated according to the protocol ELAM 02. Unfortunately, she developed multiple organ failure a few days later and died at 5 weeks.
authors.affiliation: Cliniques du Sud-Luxembourg, Arlon, Belgique. m.dekeyser@hotmail.com
authors.forename: Mélanie
authors.initials: M
authors.lastname: Dekeyser
authors.forename: Nicolas
authors.initials: N
authors.lastname: Hougardy
authors.forename: Catherine
authors.initials: C
authors.lastname: Denoncin
authors.forename: Christophe
authors.initials: C
authors.lastname: Chantrain
authors.forename: Pierre
authors.initials: P
authors.lastname: Goffinet
authors.forename: Frédéric
authors.initials: F
authors.lastname: Grandjean
mesh_terms: D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007948:Leukemia, Monocytic, Acute / Q000151:congenital* / Q000175:diagnosis*