title: Associations of long-chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates.
abstract: The purpose of this study was to examine the maternal and cord long-chain polyunsaturated fatty acid (LCPUFA) concentrations and their associations with birth outcome in term deliveries. Pregnant women (n = 253) delivering at term were divided into two groups based on their babies' birth weights (1) normal birth weight (NBW), that is, ≥2.5 kg (n = 190) and (2) low-birth weight (LBW), that is, <2.5 kg (n = 63). Each group is further divided into two groups according to the baby's sex, that is, male NBW (M-NBW), female NBW (F-NBW), male LBW (M-LBW), and female LBW (F-LBW) groups. Maternal plasma docosahexaenoic acid and erythrocyte arachidonic acid (AA) levels were lower (P < 0.05 for both), while cord plasma docosahexaenoic acid and erythrocyte AA levels were higher (P < 0.05 for both) in LBW group when compared to the NBW group. Maternal erythrocyte AA levels were positively associated with birth weight (P = 0.001), while cord plasma docosahexaenoic acid levels were negatively (P = 0.05) associated with birth weight. Reduced maternal and increased cord LCPUFA levels exist in mothers delivering LBW babies, especially in mothers delivering female babies, indicative of sex-specific effects.
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India.
authors.forename: Anitha
authors.initials: A
authors.lastname: Kilari
authors.forename: Savita
authors.initials: S
authors.lastname: Mehendale
authors.forename: Kamini
authors.initials: K
authors.lastname: Dangat
authors.forename: Hemlata
authors.initials: H
authors.lastname: Pisal
authors.forename: Sadhana
authors.initials: S
authors.lastname: Joshi
mesh_terms: D000328:Adult; D016718:Arachidonic Acid / Q000097:blood*; D001724:Birth Weight; D004281:Docosahexaenoic Acids / Q000097:blood*; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007194:India; D007231:Infant, Newborn; D008297:Male; D036801:Parturition / Q000097:blood*; D010949:Plasma / Q000737:chemistry; D011247:Pregnancy; D012737:Sex Factors; D055815:Young Adult
chemical_list: D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid