title: Adenoviral infection presenting as an isolated central nervous system disease without detectable viremia in two children after stem cell transplantation.
abstract: We report two cases of adenoviral meningoencephalitis in children following allogeneic stem cell transplantation. These cases showed four similarities: isolated neurological involvement, infiltrating hyperintensities next to the third ventricle on the cerebral magnetic resonance image, the absence of concomitant detectable adenoviral viremia, and a severe clinical outcome.
authors.affiliation: Unité d'immunologie, Hématologie et Rhumatologie Pédiatriques, Hôpital Necker Enfants malades, 149 rue de Sèvres, 75015 Paris, France. pierre.frange@nck.aphp.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Frange
authors.forename: Régis
authors.initials: R
authors.lastname: Peffault de Latour
authors.forename: Cécile
authors.initials: C
authors.lastname: Arnaud
authors.forename: Nathalie
authors.initials: N
authors.lastname: Boddaert
authors.forename: Mehdi
authors.initials: M
authors.lastname: Oualha
authors.forename: Véronique
authors.initials: V
authors.lastname: Avettand-Fenoel
authors.forename: Françoise
authors.initials: F
authors.lastname: Bernaudin
authors.forename: Claire
authors.initials: C
authors.lastname: Aguilar
authors.forename: Christine
authors.initials: C
authors.lastname: Barnerias
authors.forename: Marianne
authors.initials: M
authors.lastname: Leruez-Ville
authors.forename: Fabien
authors.initials: F
authors.lastname: Touzot
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
authors.forename: Alain
authors.initials: A
authors.lastname: Fischer
authors.forename: Stéphane
authors.initials: S
authors.lastname: Blanche
mesh_terms: D000257:Adenoviridae Infections / Q000175:diagnosis* / Q000821:virology; D000260:Adenoviruses, Human / Q000302:isolation & purification*; D000293:Adolescent; D001769:Blood / Q000821:virology; D001921:Brain / Q000000981:diagnostic imaging; D002555:Cerebrospinal Fluid / Q000821:virology; D002648:Child; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008279:Magnetic Resonance Imaging; D008590:Meningoencephalitis / Q000175:diagnosis* / Q000821:virology; D011859:Radiography; D033581:Stem Cell Transplantation / Q000009:adverse effects*