title: Bordetella petrii infection with long-lasting persistence in human.
abstract: We report the repeated isolation of Bordetella petrii in the sputum of a 79-year-old female patient with diffuse bronchiectasis and persistence of the bacterium for >1 year. The patient was first hospitalized due to dyspnea, which developed into severe cough with purulent sputum that yielded B. petrii on culture. After this first episode, the patient was hospitalized an additional 4 times with bronchorrhea symptoms. The isolates collected were analyzed by using biochemical, genotypic, and proteomic tools. Expression of specific proteins was analyzed by using serum samples from the patient. The B. petrii isolates were compared with other B. petrii isolates collected from humans or the environment and with isolates of B. pertussis, B. parapertussis, B. bronchiseptica, and B. holmesii, obtained from human respiratory tract infections. Our observations indicate that B. petrii can persist in persons with chronic pulmonary obstructive disease as has been previously demonstrated for B. bronchiseptica.
authors.affiliation: Centre Hospitalier, Cahors, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Le Coustumier
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Njamkepo
authors.forename: Vincent
authors.initials: V
authors.lastname: Cattoir
authors.forename: Sophie
authors.initials: S
authors.lastname: Guillot
authors.forename: Nicole
authors.initials: N
authors.lastname: Guiso
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism; D001884:Bordetella / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D001885:Bordetella Infections / Q000382:microbiology*; D002876:Chromosomes, Bacterial / Q000235:genetics; D005260:Female; D016680:Genome, Bacterial / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017421:Sequence Analysis; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012336:RNA, Ribosomal, 16S