title: Triterpenoids and diterpenoids from Viburnum chingii.
abstract: Two new oleanane triterpenoids (1-2) and one new vibsane-type diterpenoid (3), together with 7 known compounds (4-10), were isolated from the leaves of Viburnum chingii. The structures of compounds 1-3 were elucidated by means of spectroscopic methods including extensive 1D- and 2D-NMR technique. Cytotoxicity of compounds 1-10 were tested against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 cell lines. Compound 3 showed significant cytotoxicity against HL-60, SK-BR-3, and PANC-1 cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
authors.forename: Xuan-Qin
authors.initials: XQ
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Xiao
authors.initials: X
authors.lastname: Cheng
authors.forename: Kou
authors.initials: K
authors.lastname: Wang
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Li
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Pan
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009828:Oleanolic Acid / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D027925:Viburnum / Q000737:chemistry*; D000094042:Lupanes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D009828:Oleanolic Acid; D014315:Triterpenes; C559416:1alpha,3beta-dihydroxy-11a -methoxy-olean-12-ene; C559417:1alpha,3beta-dihydroxy-olean-9(11),12-dien; C559418:2alpha,3beta -dihydroxy-20(29)-lupene; D000094042:Lupanes