title: Functional polymorphism of interferon-γ (IFN-γ) gene +874T/A polymorphism is associated with pulmonary tuberculosis in Zahedan, Southeast Iran.
abstract: Concerning the key role of interferon-γ (IFN-γ) in the protective immunity against Mycobacterium tuberculosis, we aimed to find the possible association between single nucleotide polymorphism of IFN-γ +874T/A (rs61923114) and pulmonary tuberculosis (PTB). This case-control study was performed on 142 PTB patients and 166 healthy subjects. Genotype analysis was done using amplification refractory mutation system-PCR (ARMS-PCR). We found that the AA genotype of +874A/T IFN-γ is a risk factor for PTB (OR = 3.333, 95% CI = 1.537-7.236, p=0.002). The results showed that the +874A allele frequency was higher in PTB than in normal subjects (OR = 1.561, 95% CI = 1.134-2.480, p=0.007). In conclusion, significant association was found between the IFN-γ +874T/A polymorphism (rs61923114) and susceptibility to PTB in a sample of Iranian population.
authors.affiliation: Department of Clinical Biochemistry, Zahedan University of Medical Sciences, Zahedan, Iran. mhd.hashemi@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Hashemi
authors.forename: B
authors.initials: B
authors.lastname: Sharifi-Mood
authors.forename: M
authors.initials: M
authors.lastname: Nezamdoost
authors.forename: A
authors.initials: A
authors.lastname: Moazeni-Roodi
authors.forename: M
authors.initials: M
authors.lastname: Naderi
authors.forename: H
authors.initials: H
authors.lastname: Kouhpayeh
authors.forename: M
authors.initials: M
authors.lastname: Taheri
authors.forename: S
authors.initials: S
authors.lastname: Ghavami
mesh_terms: D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D007492:Iran; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D007371:Interferon-gamma