title: Diabetes in acromegaly, prevalence, risk factors, and evolution: data from the French Acromegaly Registry.
abstract: OBJECTIVE
  The French Acromegaly Registry records data of acromegalic patients' since 1992 in French, Belgian (Liège), and Swiss (Lausanne) centers. We studied the prevalence of diabetes in this population looking for risk factors. Patients from one of the centers (Reims) were then analyzed more thoroughly.
  
  
  METHODS
  This study has been conducted on all the patients recorded from 1999 until 2004 (519 patients). Evolution of cohorts' was reassessed in 2009. Of the different variables recorded in the registry: age, sex, body mass index (BMI), duration of acromegaly, GH, IGF1 and prolactin levels, pituitary tumor size, hormonal deficiencies, presence, duration and treatment of diabetes, hypertension, and rheumatological disease were analyzed.
  
  
  RESULTS
  The prevalence of diabetes in the registry was 22.3%. Diabetic patients were older and had a higher BMI. Compared with the data of the French Social Security, acromegalic patients showed a more precocious apparition of diabetes and prevalence was higher in each age group. Compared with non-diabetic acromegalic subjects, diabetic patients had a more prolonged evolution of acromegaly before diagnosis. The levels of GH and IGF1 were not significantly different between the two groups. Only hypertension was significantly more frequent in diabetic patients.
  
  
  CONCLUSIONS
  In our population, the prevalence of diabetes was estimated to be 22.3%. The GH and IGF1 levels did not appear as predictive factors for the presence of diabetes. On the contrary, age, BMI, and hypertension were significant risk factors as in the general population of type 2 diabetics.
authors.affiliation: Service d'Endocrinologie, Hôpital Robert Debre, CHU de Reims, Rue Du General Koenig, 51092 Reims, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Fieffe
authors.forename: Isabelle
authors.initials: I
authors.lastname: Morange
authors.forename: Patrick
authors.initials: P
authors.lastname: Petrossians
authors.forename: Philippe
authors.initials: P
authors.lastname: Chanson
authors.forename: Vincent
authors.initials: V
authors.lastname: Rohmer
authors.forename: Christine
authors.initials: C
authors.lastname: Cortet
authors.forename: Françoise
authors.initials: F
authors.lastname: Borson-Chazot
authors.forename: Thierry
authors.initials: T
authors.lastname: Brue
authors.forename: Brigitte
authors.initials: B
authors.lastname: Delemer
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D015992:Body Mass Index; D002648:Child; D016208:Databases, Factual; D048909:Diabetes Complications / Q000453:epidemiology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010911:Pituitary Neoplasms / Q000150:complications / Q000453:epidemiology; D012042:Registries; D012307:Risk Factors; D012744:Sex Ratio; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I