title: A case of intraductal papillary neoplasm of the bile duct with stromal invasion.
abstract: Intraductal papillary neoplasm of the bile duct (IPNB) represents biliary papillary tumors mainly growing and is considered to be of relatively low-grade malignancy. Here we report a case of IPNB in whom the poorly differentiated component deeply infiltrated the bile duct wall. A 77-year-old male had an invasive carcinoma of the bile duct 3 cm in size. He underwent right hemihepatectomy with combined resection of the extrahepatic bile duct. Papillary growing tumor was observed in the common bile duct and the right posterior Glisson's pedicle was invaded. Histologic finding showed papillary adenocarcinoma in the surface layer superficially extending to the epithelium of the surrounding bile duct. In the subserosal layer, the tumor represented poorly differentiated adenocarcinoma. The tumor was diagnosed as invasive bile duct carcinoma arising from IPNB.
authors.affiliation: Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nanashima
authors.forename: Yorihisa
authors.initials: Y
authors.lastname: Sumida
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tomoshige
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeshita
authors.forename: Kenichirou
authors.initials: K
authors.lastname: Shibata
authors.forename: Terumitsu
authors.initials: T
authors.lastname: Sawai
authors.forename: Toru
authors.initials: T
authors.lastname: Yasutake
authors.forename: Naoe
authors.initials: N
authors.lastname: Kinoshita
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yasuni
authors.initials: Y
authors.lastname: Nakanuma
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagayasu