title: Enantioselective organocatalytic Michael-hemiketalization catalyzed by a trans-bifunctional indane thiourea catalyst.
abstract: An efficient, convenient and enantioselective Michael-hemiketalization reaction has been developed for the synthesis of naphthoquinones. In this work, a novel trans-bifunctional indane thiourea catalyst has been reported to promote this process to afford high yields (up to 99%) and high to excellent enantiomeric excesses (90-98% ee).
authors.affiliation: Department of Chemistry, National University of Singapore, Singapore.
authors.forename: Yaojun
authors.initials: Y
authors.lastname: Gao
authors.forename: Qiao
authors.initials: Q
authors.lastname: Ren
authors.forename: Swee-Meng
authors.initials: SM
authors.lastname: Ang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D006860:Hydrogen Bonding; D007659:Ketones / Q000737:chemistry*; D009285:Naphthoquinones / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity; D013890:Thiourea / Q000737:chemistry*
chemical_list: D007659:Ketones; D009285:Naphthoquinones; D013890:Thiourea