title: The birth and life of lipid droplets: learning from the hepatitis C virus.
abstract: LDs (lipid droplets) are probably the least well-characterized cellular organelles. Having long been considered simple lipid storage depots, they are now considered to be dynamic organelles involved in many biological processes. However, most of the mechanisms driving LDs biogenesis, growth and intracellular movement remain largely unknown. As for other cellular mechanisms deciphered through the study of viral models, HCV (hepatitis C virus) is an original and relevant model for investigations of the birth and life of these organelles. Recent studies in this model have raised the hypothesis that the HCV core protein induces the redistribution of LDs through the regression and regeneration of these organelles in specific intracellular domains.
authors.affiliation: Laboratoire de Biologie Cellulaire, INSERM U966, Faculté de Médecine, Université François Rabelais and CHRU de Tours, 10 Boulevard Tonnellé, 37032 Tours, France. roingeard@med.univ-tours.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Roingeard
authors.forename: Marion
authors.initials: M
authors.lastname: Depla
mesh_terms: D000818:Animals; D016174:Hepacivirus / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D008055:Lipids / Q000737:chemistry; D015388:Organelles / Q000378:metabolism
chemical_list: D008055:Lipids