title: A dual-catalysis/anion-binding approach to the kinetic resolution of allylic amines.
abstract: A dual-catalysis approach enables the small-molecule catalyzed kinetic resolution of allylic amines by acylation. By employing 2 mol % of each 4-(pyrrolidino)pyridine (PPY) and a readily available chiral hydrogen-bonding cocatalyst, the first nonenzymatic kinetic resolution of allylic amines was accomplished with s factors of up to 20.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.
authors.forename: Eric G
authors.initials: EG
authors.lastname: Klauber
authors.forename: Nisha
authors.initials: N
authors.lastname: Mittal
authors.forename: Tejas K
authors.initials: TK
authors.lastname: Shah
authors.forename: Daniel
authors.initials: D
authors.lastname: Seidel
mesh_terms: D000588:Amines / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D002384:Catalysis; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000588:Amines; D000838:Anions