title: Expression of rh glycoproteins in the Mammalian kidney.
abstract: Ammonia metabolism is a fundamental process in the maintenance of life in all living organisms. Recent studies have identified ammonia transporter family proteins in yeast (Mep), plants (Amt), and mammals (Rh glycoproteins). In mammalian kidneys, where ammonia metabolism and transport are critically important for the regulation of systemic acid-base homeostasis, basolateral Rh B glycoprotein and apical/basolateral Rh C glycoprotein are expressed along the distal nephron segments. Data from experimental animal models and knockout mice suggest that the Rh glycoproteins appear to mediate important roles in urinary ammonia excretion.
authors.affiliation: Department of Anatomy, Ewha Womans University School of Medicine, Seoul, Korea.
authors.forename: Ki-Hwan
authors.initials: KH
authors.lastname: Han
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Kim
authors.forename: I David
authors.initials: ID
authors.lastname: Weiner