title: Tyrosinase inhibitory potential of natural products isolated from various medicinal plants.
abstract: Seven secondary metabolites, p-hydroxybenzoic acid (1), 3,4-dihydroxybenzoic acid (2), ferulic acid (3), 2,6-dimethoxy-4-hydroxy acetophenone (4), lupeol (5), 2'-O-ethylmurrangatin (6) and hibiscetin heptamethyl ether (7) were the natural products isolated from various medicinal plants. Their structures were identified by spectral comparison with previously reported data. The compounds 1-7 were screened for their tyrosinase-inhibitory activity. The compound p-hydroxybenzoic acid (1) was found to have potent activity against tyrosinase enzyme, whereas lupeol (5) showed significant activity.
authors.affiliation: Department of Chemistry, Federal Urdu University for Arts, Science and Technology,Gulshan-e-Iqbal Campus, Karachi 75300, Pakistan. azizpobox1@yahoo.com
authors.lastname: Azizuddin
authors.forename: A Majeed
authors.initials: AM
authors.lastname: Khan
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000098:Acetophenones / Q000737:chemistry* / Q000494:pharmacology; D003373:Coumaric Acids / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology; D062385:Hydroxybenzoates / Q000494:pharmacology; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D053978:Pentacyclic Triterpenes / Q000494:pharmacology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D000094042:Lupanes
chemical_list: D000098:Acetophenones; D003373:Coumaric Acids; D003374:Coumarins; D047309:Flavones; D062385:Hydroxybenzoates; D014442:Monophenol Monooxygenase; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; C452986:2'-O-ethylmurrangatin; C568201:2,6-dimethoxy-4-hydroxyacetophenone; C568202:hibiscetin heptamethyl ether; C009091:protocatechuic acid; C004999:ferulic acid; C010480:lupeol; D000094042:Lupanes