title: Fluorescence in situ hybridization mapping of six loci containing genes involved in the dioxin metabolism of domestic bovids.
abstract: Six loci containing genes involved in the dioxin metabolism (ARNT, AHR, CYP1A1, CYP1A2, CYP1B1 and AHRR) were assigned, for the first time, to cattle (Bos taurus, 2n = 60, BTA), river buffalo (Bubalus bubalis, 2n = 50, BBU), sheep (Ovis aries, 2n = 54, OAR) and goat (Capra hircus, 2n = 60, CHI) chromosomes by comparative FISH-mapping and R-banding using bovine BAC-clones. The following chromosome locations were found: ARNT to BTA3q21, BBU6q21, OAR1p21 and CHI3q21, AHR to BTA4q15, BBU8q15, OAR4q15 and CHI4q15; CYP1A1 and CYP1A2 to BTA21q17, BBU20q17, OAR18q17 and CHI21q17; CYP1B1 to BTA11q16, BBU12q22, OAR3p16 and CHI11q16, AHRR to BTA20q24, BBU19q24, OAR16q24 and CHI20q24. All loci were mapped at the same homoeologous chromosomes and chromosome bands of the four bovid species. Comparisons with corresponding human locations were also reported.
authors.affiliation: Laboratory of Animal Cytogenetics and Gene Mapping, National Research Council (CNR), ISPAAM, Via Argine 1085, 80147, Naples, Italy.
authors.forename: Viviana
authors.initials: V
authors.lastname: Genualdo
authors.forename: Veronica
authors.initials: V
authors.lastname: Spalenza
authors.forename: Angela
authors.initials: A
authors.lastname: Perucatti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Iannuzzi
authors.forename: Giulia Pia
authors.initials: GP
authors.lastname: Di Meo
authors.forename: Annamaria
authors.initials: A
authors.lastname: Caputi-Jambrenghi
authors.forename: Gino
authors.initials: G
authors.lastname: Vonghia
authors.forename: Roberto
authors.initials: R
authors.lastname: Rasero
authors.forename: Carlo
authors.initials: C
authors.lastname: Nebbia
authors.forename: Paola
authors.initials: P
authors.lastname: Sacchi
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Iannuzzi
mesh_terms: D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000235:genetics; D002020:Buffaloes / Q000235:genetics; D002417:Cattle; D002871:Chromosome Banding; D002874:Chromosome Mapping; D004147:Dioxins / Q000378:metabolism*; D056426:Genetic Loci; D006041:Goats / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics; D012756:Sheep / Q000235:genetics
chemical_list: D004147:Dioxins; D018336:Receptors, Aryl Hydrocarbon; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D001189:Aryl Hydrocarbon Hydroxylases