title: Experimental asexual blood stage malaria immunity.
abstract: Immunity to asexual blood stages of malaria is complex, involving both humoral and cell-mediated immune mechanisms. The availability of murine models of malaria has greatly facilitated the analysis of immune mechanisms involved in resistance to the asexual blood stages. This unit details the materials and methods required for inducing protective immunity toward experimental blood stage malaria parasites by vaccination, repeated infection, and drug cure, as well as adoptive transfer of antigen-specific T cells.
authors.affiliation: The Queensland Institute of Medical Research, Australia.
authors.forename: Fiona H
authors.initials: FH
authors.lastname: Amante
authors.forename: Christian R
authors.initials: CR
authors.lastname: Engwerda
authors.forename: Michael F
authors.initials: MF
authors.lastname: Good
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D019264:Adoptive Transfer / Q000379:methods; D000818:Animals; D000953:Antigens, Protozoan / Q000008:administration & dosage / Q000276:immunology; D000962:Antimalarials / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D015925:Cryopreservation / Q000379:methods; D004195:Disease Models, Animal; D008018:Life Cycle Stages / Q000276:immunology*; D008288:Malaria / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology / Q000473:pathology; D020066:Merozoite Surface Protein 1 / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D018512:Parasitemia / Q000188:drug therapy; D010962:Plasmodium berghei / Q000276:immunology; D010967:Plasmodium yoelii / Q000276:immunology; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D014611:Vaccination / Q000379:methods
chemical_list: D000276:Adjuvants, Immunologic; D000953:Antigens, Protozoan; D000962:Antimalarials; D020066:Merozoite Surface Protein 1; D011994:Recombinant Proteins