title: Use of swLORETA to localize the cortical sources of target- and distracter-elicited P300 components.
abstract: OBJECTIVE
  Cognitive event-related potentials (especially P300) have long been used to explore attentional processes. The aim of this study was to identify the cortical areas involved in P300 generation during a selective attention task.
  
  
  METHODS
  128 channel electroencephalograms were recorded in 15 healthy controls performing a three-stimulus visual oddball paradigm, in order to identify distracter- and target-elicited P300 components. For each subject, the P300 sources were localized using standardized weighted low-resolution electromagnetic tomography (swLORETA). One sample and paired T-tests were performed using SPM5®.
  
  
  RESULTS
  Common sources for both P300 components were observed within a large frontoparietal network, including the frontal eye field and dorsal parietal cortex (i.e. the attentional dorsal frontoparietal network). More inferior parietal areas, prefrontal and cingulate cortices (i.e. the attentional ventral frontoparietal network) were also involved in the generation of target-elicited P300.
  
  
  CONCLUSIONS
  These results suggest that distracter- and target-elicited P300 are both generated by the dorsal frontoparietal network. Moreover, target processing recruits a specific ventral network.
  
  
  CONCLUSIONS
  Our data agree with the literature reports using other methods and should help to improve our knowledge of the cerebral networks underlying attentional processes.
authors.affiliation: Université Lille Nord de France, UDSL, Ibis Rue Georges Lefevre 59000 Lille, France. pebocq@hotmail.fr
authors.forename: Perrine
authors.initials: P
authors.lastname: Bocquillon
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Bourriez
authors.forename: Ernesto
authors.initials: E
authors.lastname: Palmero-Soler
authors.forename: Nacim
authors.initials: N
authors.lastname: Betrouni
authors.forename: Elise
authors.initials: E
authors.lastname: Houdayer
authors.forename: Philippe
authors.initials: P
authors.lastname: Derambure
authors.forename: Kathy
authors.initials: K
authors.lastname: Dujardin
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D055590:Electromagnetic Phenomena; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods* / Q000592:standards; D008297:Male; D009415:Nerve Net / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods*; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D014054:Tomography / Q000379:methods* / Q000592:standards; D055815:Young Adult