title: Anti-inflammatory and cytotoxic activities of chichipegenin, peniocerol, and macdougallin isolated from Myrtillocactus geometrizans (Mart. ex Pfeiff.) Con.
abstract: The oleanane-type triterpene chichipegenin and the sterols peniocerol and macdougallin, isolated from Myrtillocactus geometrizans, showed anti-inflammatory activities in both the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema model and the carrageenan-induced rat paw edema model. All tested compounds inhibited the TPA-induced edema in a dose-dependent manner, with ED50 values less than or equal to that shown by indomethacin. Among them, peniocerol was the most active compound. However, only peniocerol and macdougallin reduced carrageenan-induced rat paw edema. On the other hand, peniocerol and macdougallin showed cytotoxicity against several human cancer cell lines. These results indicate that compounds isolated from M. geometrizans possess antiinflammatory and cytotoxic properties, and the presence of chichipegenin in the aerial parts could justify the medicinal uses attributed to the plant.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Coyoacán, C. P. 04510, México, D. F., México.
authors.forename: Juan Rodrigo
authors.initials: JR
authors.lastname: Salazar
authors.forename: Mariano
authors.initials: M
authors.lastname: Martínez-Vazquez
authors.forename: Carlos L
authors.initials: CL
authors.lastname: Cespedes
authors.forename: Teresa
authors.initials: T
authors.lastname: Ramírez-Apan
authors.forename: Antonio
authors.initials: A
authors.lastname: Nieto-Camacho
authors.forename: Juan
authors.initials: J
authors.lastname: Rodríguez-Silverio
authors.forename: Francisco
authors.initials: F
authors.lastname: Flores-Murrieta
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D029421:Cactaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D008297:Male; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*; D013261:Sterols / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D013261:Sterols; C558189:chichipegenin; C558191:macdougallin; C558190:peniocerol; D009828:Oleanolic Acid