title: Serum biochemical analysis to indicate pathogenic risk on mouse Mus musculus exposure to source of drinking water.
abstract: The 18 biochemical parameters of serum were measured to analyze the pathogenic risks of the Yangtze River Source of Drinking Water in Nanjing area (YZR-SDW-NJ) on mouse Mus musculus for protection of human health in this research. The male mice Mus musculus were sampled and fed with YZR-SDW-NJ for 90 days then the eighteen serum biochemical levels were measured with Automatic Biochemical Analysis/RerLi 600. And the parameter data were treated by One-Way ANOVA statistic approach. The results showed that five parameter levels for the sample group mice were different from those for the control group significantly (0.01 < P or 0.05 < P). Four 4 of the 5 altered parameter levels were decreased including glutamate pyruvate transaminase 38% lower, glutamine-oxaloacetic transaminase 24% lower, triglyceride 76% lower and cystatin C 73% lower, only creatinine level was 26% higher than that in the control group. The data suggest that YZR-SDW-NJ had toxicity on the mouse and the organic pollutants in YZR-SDW-NJ might lead to liver, kidney, cardiovascular and metabolic pathogenic risks on the human beings. The results might be cited as evidence to control pollutants in the source water for the protection of NJ people's health.
authors.affiliation: Department of Comparative Medicine, Jinling Hospital, 305 Zhongshang Donglu, Nanjing, 210002, China.
authors.forename: Shi Feng
authors.initials: SF
authors.lastname: Yun
authors.forename: Xiao Yun
authors.initials: XY
authors.lastname: Tian
authors.forename: Shu Pei
authors.initials: SP
authors.lastname: Cheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ai Min
authors.initials: AM
authors.lastname: Li
authors.forename: Li Bo
authors.initials: LB
authors.lastname: Zhang
authors.forename: Xu Xiang
authors.initials: XX
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.forename: Lian Qin
authors.initials: LQ
authors.lastname: Guo
authors.forename: Yun Zhong
authors.initials: YZ
authors.lastname: Shi
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D002681:China; D002947:Cities; D004784:Environmental Monitoring / Q000379:methods; D005618:Fresh Water / Q000737:chemistry; D008297:Male; D051379:Mice; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000633:toxicity; D018570:Risk Assessment; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*; D014881:Water Supply / Q000032:analysis* / Q000706:statistics & numerical data
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D014874:Water Pollutants, Chemical; D000410:Alanine Transaminase