title: [A case of squamous cell carcinoma of the lung with bilateral diffuse uveal melanocytic proliferation (BDUMP) diagnosed by visual disturbance].
abstract: A 50-year-old man presented with visual disturbance at a local ophthalmology clinic. He was given a diagnosis of uveitis and treated with oral corticosteroids; however, his visual disturbance did not improve and he was admitted to our hospital. A chest CT scan showed a pulmonary nodule in the upper lobe of the right lung, and right hilar and mediastinal lymphadenopathy. Transbronchial biopsy yielded a diagnosis of squamous cell carcinoma, and an ophthalmologic examination revealed bilateral diffuse uveal melanocytic proliferation (BDUMP). BDUMP is a rare manifestation of paraneoplastic syndrome, and the characteristics of the condition have not yet been clarified in detail. BDUMP carries a very poor visual prognosis, and in the present case, the patient's visual disturbance progressed rapidly despite systemic chemotherapy and corticosteroid therapy.
authors.affiliation: Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shinmura
authors.forename: Daichi
authors.initials: D
authors.lastname: Hamasaki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Koichi
authors.initials: K
authors.lastname: Takagi
authors.forename: Yukari
authors.initials: Y
authors.lastname: Sadamura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Momi
authors.forename: Ikkou
authors.initials: I
authors.lastname: Higashimoto
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Inoue
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D008875:Middle Aged; D010257:Paraneoplastic Syndromes; D014602:Uvea / Q000473:pathology*; D014786:Vision Disorders / Q000209:etiology*