title: Ubiquitylation of DNA polymerase λ.
abstract: DNA polymerase (pol) λ, one of the 15 cellular pols, belongs to the X family. It is a small 575 amino-acid protein containing a polymerase, a dRP-lyase, a proline/serine rich and a BRCT domain. Pol λ shows various enzymatic activities including DNA polymerization, terminal transferase and dRP-lyase. It has been implicated to play a role in several DNA repair pathways, particularly base excision repair (BER), non-homologous end-joining (NHEJ) and translesion DNA synthesis (TLS). Similarly to other DNA repair enzymes, pol λ undergoes posttranslational modifications during the cell cycle that regulate its stability and possibly its subcellular localization. Here we describe our knowledge about ubiquitylation of pol λ and the impact of this modification on its regulation.
authors.affiliation: Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
authors.forename: Enni
authors.initials: E
authors.lastname: Markkanen
authors.forename: Barbara
authors.initials: B
authors.lastname: van Loon
authors.forename: Elena
authors.initials: E
authors.lastname: Ferrari
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hübscher
mesh_terms: D001665:Binding Sites / Q000235:genetics; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000378:metabolism; D019951:DNA Polymerase beta / Q000235:genetics / Q000378:metabolism*; D004260:DNA Repair; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D054875:Ubiquitination
chemical_list: D004268:DNA-Binding Proteins; C101467:XRCC4 protein, human; D004247:DNA; C415367:DNA polymerase beta2; D019951:DNA Polymerase beta; D011088:DNA Ligases; D000072481:DNA Ligase ATP