title: Cuban Meningococcal BC Vaccine: Experiences & Contributions from 20 Years of Application.
abstract: This paper reviews 20 years of experience and scientific contributions of the Cuban meningococcal BC vaccine (VA-MENGOC-BC®) obtained by the Finlay Institute in Havana, Cuba. The vaccine is the first of its type in the world that is safe, effective, and commercially available for preventing meningococcal disease caused by serogroup B meningococcus; it is also effective against serogroup C. VA-MENGOC-BC® has shown satisfactory results, with no serious adverse events, after application of approximately 55 million doses in some 15 countries. Also included is background information on meningococcal disease, as well as the main characteristics of VA-MENGOC-BC®, the strategy used for controlling meningococcal disease and its prevention in Cuba, and a summary of the main scientific results obtained in basic research, development, clinical evaluation, and post-marketing results (safety, efficacy-effectiveness, post-vaccination adverse events, etc.) in Cuba and elsewhere.
authors.affiliation: fsotolongo@finlay.edu.cu. Finlay Institute, Havana, Cuba.
authors.forename: Franklin
authors.initials: F
authors.lastname: Sotolongo
authors.forename: Concepción
authors.initials: C
authors.lastname: Campa
authors.forename: Victoria
authors.initials: V
authors.lastname: Casanueva
authors.forename: Esther María
authors.initials: EM
authors.lastname: Fajardo
authors.forename: Iván Edelberto
authors.initials: IE
authors.lastname: Cuevas
authors.forename: Noel
authors.initials: N
authors.lastname: González