title: Why does depression hurt? Ancestral primary-process separation-distress (PANIC/GRIEF) and diminished brain reward (SEEKING) processes in the genesis of depressive affect.
authors.affiliation: Department of VCAPP, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6351, USA. jpanksepp@vetmed.wsu.edu
authors.forename: Jaak
authors.initials: J
authors.lastname: Panksepp
authors.forename: Douglas
authors.initials: D
authors.lastname: Watt
mesh_terms: D000339:Affect; D000818:Animals; D005075:Biological Evolution; D001921:Brain / Q000503:physiopathology*; D002047:Buprenorphine / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D004195:Disease Models, Animal; D006117:Grief; D006801:Humans; D008959:Models, Neurological; D010200:Panic; D012201:Reward
chemical_list: D002047:Buprenorphine