title: A rare case of microgranular acute promyelocytic leukemia associated with ider(17)(q10)t(15;17) in an old-age patient.
abstract: We present a rare case of microgranular variant acute promyelocytic leukemia (APL) associated with ider(17)(q10)t(15;17)(q22;q12) of an old-age patient. The initial chromosome study showed a 46,XX,del(6)(?q21q25),der(15)t(15;17)(q22;q12),ider(17)(q10)t(15;17)[10]/47,sl,+ider(17)(q10)t(15;17)[3]/46,XX[16]. FISH signals from a dual color dual fusion translocation PML-RARA probe were consistent with the results of conventional cytogenetics. Because of the rarity of ider(17)(q10)t(15;17) in microgranular APL, further studies on both gene dosage effect of this chromosomal abnormality and the influence of ider(17)(q10)t(15;17) on clinical features such as prognosis, survival, and treatment response of APL cases are recommended.
authors.affiliation: Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Min Jin
authors.initials: MJ
authors.lastname: Kim
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Cho
authors.forename: Gayoung
authors.initials: G
authors.lastname: Lim
authors.forename: Hoi Soo
authors.initials: HS
authors.lastname: Yoon
authors.forename: Hee Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jin-Tae
authors.initials: JT
authors.lastname: Suh
authors.forename: Juhie
authors.initials: J
authors.lastname: Lee
authors.forename: Woo-In
authors.initials: WI
authors.lastname: Lee
authors.forename: Kyung Sam
authors.initials: KS
authors.lastname: Cho
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
mesh_terms: D001854:Bone Marrow Cells / Q000473:pathology; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein