title: Prediction of symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage with an artificial neural network: feasibility and comparison with logistic regression models.
abstract: OBJECTIVE
  To create a simple artificial neural network (ANN) to predict the occurrence of symptomatic cerebral vasospasm (SCV) after aneurysmal subarachnoid hemorrhage (aSAH) based on clinical and radiographic factors and test its predictive ability against existing multiple logistic regression (MLR) models.
  
  
  METHODS
  A retrospective database of patients admitted to a single academic medical center with confirmed aSAH between January 2002 and January 2007 (91 patients) was input to a back-propagation ANN program freely available to academicians on the Internet. The resulting ANN was prospectively tested against two previously published MLR prediction models for all patients admitted the following year (22 patients). The models were compared for their predictive accuracy with receiver operating characteristic (ROC) curve analysis.
  
  
  RESULTS
  All models were accurate with their prediction of patients with SCV. The ANN had superior predictive value compared with the MLR models, with a significantly improved area under ROC curve (0.960 ± 0.044 vs 0.933 ± 0.54 and 0.897 ± 0.069 for MLR models).
  
  
  CONCLUSIONS
  A simple ANN model was more sensitive and specific than MLR models in prediction of SCV in patients with aSAH. The conception of ANN modeling for cerebral vasospasm is introduced for a neurosurgical audience. With advanced ANN modeling, the clinician may expect to build improved models with more powerful prediction capabilities.
authors.affiliation: From the Division of Neurosurgery, Departmentof Surgery, University of Vermont, Burlington,Vermont, USA. Travis.Dumont@vtmednet.org
authors.forename: Travis M
authors.initials: TM
authors.lastname: Dumont
authors.forename: Anand I
authors.initials: AI
authors.lastname: Rughani
authors.forename: Bruce I
authors.initials: BI
authors.lastname: Tranmer
mesh_terms: D003198:Computer Simulation / Q000639:trends*; D003943:Diagnostic Techniques, Neurological / Q000639:trends*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D020301:Vasospasm, Intracranial / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology