title: [Early detection of prostate cancer in Senegalese men 40-50 years old].
abstract: OBJECTIVE
  To detect prostate cancer in young black men and compare our results with those of western studies.
  
  
  METHODS
  The authors conducted a prospective multicenter study from February 2008 to May 2009 on 220 men aged 40 to 49 years. All patients with an abnormal prostate suspicious of cancer and/or a PSA greater than 2.5 ng/ml had a prostate biopsy.
  
  
  RESULTS
  The mean age of patients was 44.99 years. The mean PSA was 26.62 ng/ml and ranged from 0.3 to 5600 ng/ml, with a median PSA of 0.88 ng/ml. Eleven patients had a PSA greater than 2.5 ng/ml and three had abnormal prostates suspicious of cancer. Twelve patients had a prostate biopsy. Histologic studies of the specimens found one case of prostate adenocarcinoma (Gleason 4+4) and two cases of high grade prostate intraepithelial neoplasia (HGPIN), all within the 46 to 50 years age group.
  
  
  CONCLUSIONS
  Due to the absence of prostate cancer within the 40 to 45 years age group, we would not recommend the screening of prostate cancer within this age group. This is only a preliminary study, and should be completed with the search for familial forms of prostate cancer. Also, a regular follow-up of patients already presenting with PSA greater than 2.5 ng/ml or HGPIN should be considered.
authors.affiliation: Service d'urologie-andrologie, CHU Aristide-Le-Dantec, avenue Pasteur, BP 35354, Dakar, Sénégal. sarramoc@yahoo.fr
authors.forename: S
authors.initials: S
authors.lastname: Alioune
authors.forename: S
authors.initials: S
authors.lastname: Yaya
authors.forename: T
authors.initials: T
authors.lastname: Ibou
authors.forename: F
authors.initials: F
authors.lastname: Boubacar
authors.forename: D
authors.initials: D
authors.lastname: Babacar
authors.forename: F P
authors.initials: FP
authors.lastname: Ahmed
authors.forename: B
authors.initials: B
authors.lastname: Mamadou
authors.forename: T
authors.initials: T
authors.lastname: Meissa
authors.forename: D B
authors.initials: DB
authors.lastname: Assane
mesh_terms: D000328:Adult; D042241:Early Diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D012675:Senegal / Q000453:epidemiology
chemical_list: D017430:Prostate-Specific Antigen