title: A more comprehensive and highly practical solution to enantioselective aldehyde crotylation.
abstract: The enantioselective crotylation of aldehydes with 1,2-diaminochlorocrotylsilane reagents is effectively catalyzed by Sc(OTf)(3). The one significant limitation on the utility of these reagents--substrate scope--has thus been addressed. The net result is the most comprehensive and highly practical method for enantioselective aldehyde crotylation yet advanced.
authors.affiliation: Department of Chemistry, Columbia University, New York, New York 10027, USA.
authors.forename: Hyunwoo
authors.initials: H
authors.lastname: Kim
authors.forename: Stephen
authors.initials: S
authors.lastname: Ho
authors.forename: James L
authors.initials: JL
authors.lastname: Leighton
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D012821:Silanes; C507609:crotylsilane