title: The role of platelet-rich plasma in inguinal wound healing in vascular surgery patients.
abstract: The objective was to determine whether incision application of platelet-rich plasma (PRP) will decrease postoperative wound complications in vascular surgery patients. A prospective, randomized trial randomized 81 incisions in 51 patients who underwent femoral artery exposure for elective revascularization procedures or endovascular abdominal aneurysm repairs. Incidence of diabetes, chronic renal failure, prosthetic grafts, body mass index (BMI), and steroid use did not differ. Using the ASEPSIS wound classification system, we found no difference in incidence of wound infection. Wound complications occurred in 9 (23%) of 40 of PRP group and 9 (22%) of 41 of non-PRP. Severe wound complications developed in 5 (13%) PRP and 6 (5%) of non-PRP (P = NS). In multivariate analysis, there were no predictors for wound infection. Groin wound complications rates are common in this patient group. Platelet-rich plasma did not decrease the incidence of groin wound complications in our patients.
authors.affiliation: Division of Vascular Surgery, London Health Sciences Centre and The University of Western Ontario, London, Ontario, Canada. Klawlor@uwo.ca
authors.forename: D Kirk
authors.initials: DK
authors.lastname: Lawlor
authors.forename: Guy
authors.initials: G
authors.lastname: Derose
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Harris
authors.forename: Marge B
authors.initials: MB
authors.lastname: Lovell
authors.forename: Teresa V
authors.initials: TV
authors.lastname: Novick
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Forbes
mesh_terms: D000368:Aged; D005263:Femoral Artery / Q000601:surgery*; D006119:Groin / Q000601:surgery; D006801:Humans; D009864:Ontario; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013530:Surgical Wound Infection / Q000209:etiology* / Q000517:prevention & control; D013997:Time Factors; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects*; D058106:Wound Closure Techniques; D014945:Wound Healing