title: [Clinical study on cytokine induced killer cells therapy to laryngeal cancer after radiotherapy].
abstract: OBJECTIVE
  To observe the immunity changes of patients after CIK cells being transfused back, and then to discuss the effects of CIK cells on curing laryngeal cancers.
  
  
  METHODS
  Forty eight laryngeal cancer patients with low immune function were collected. The immunity index in the peripheral blood of patients before/after radiotherapy and after CIK cells therapy were measured and compared with normal one.
  
  
  RESULTS
  After radiotherapy, the percentage of CD3+, CD4+ cells declined, the percentage of CD8+ cells increased; the rate of CD4+ /CD8+ declined and the rate of Th1/Th2 reversed. There were no significant difference between the immunity indexes before and after radiotherapy (P < 0.05). After CIK cell therapy, the above indexes were improved (P < 0.05), but the values didn't returned to normal. After radiotherapy and after CIK therapy, the value of B cell didn't changed obviously (P > 0.05), while the percentage of NK cells changed obviously (P < 0.05).
  
  
  CONCLUSIONS
  Radiotherapy can restrain the immune function of the patients with laryngeal cancers. CIK therapy is safe and might improve the recent immune function of the patients.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, the Third Affiliated Hospital of Kunming College, Kunming, 650118, China.
authors.forename: Shiwen
authors.initials: S
authors.lastname: Zhang
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: He
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Li
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Ren
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy; D003131:Combined Modality Therapy; D055612:Cytokine-Induced Killer Cells / Q000276:immunology*; D006801:Humans; D016219:Immunotherapy, Adoptive; D007694:Killer Cells, Natural / Q000276:immunology; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging