title: Regulatory T cells and Foxp3.
abstract: Regulatory T (Treg) cells play central role in regulation of immune responses to self-antigens, allergens, and commensal microbiota as well as immune responses to infectious agents and tumors. Transcriptional factor Foxp3 serves as a lineage specification factor of Treg cells. Paucity of Treg cells due to loss-of-function mutations of the Foxp3 gene is responsible for highly aggressive, fatal, systemic immune-mediated inflammatory lesions in mice and humans. Recent studies of Foxp3 expression and function provided critical novel insights into biology of Treg cells and into cellular mechanisms of the immune homeostasis.
authors.affiliation: Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. rudenska@mskcc.org
authors.forename: Alexander Y
authors.initials: AY
authors.lastname: Rudensky
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D019070:Cell Lineage; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics / Q000276:immunology*; D051379:Mice; D009154:Mutation / Q000235:genetics; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors