title: Complex flow patterns in a real-size intracranial aneurysm phantom: phase contrast MRI compared with particle image velocimetry and computational fluid dynamics.
abstract: The aim of this study was to validate the flow patterns measured by high-resolution, time-resolved, three-dimensional phase contrast MRI in a real-size intracranial aneurysm phantom. Retrospectively gated three-dimensional phase contrast MRI was performed in an intracranial aneurysm phantom at a resolution of 0.2 × 0.2 × 0.3 mm(3) in a solenoid rat coil. Both steady and pulsatile flows were applied. The phase contrast MRI measurements were compared with particle image velocimetry measurements and computational fluid dynamics simulations. A quantitative comparison was performed by calculating the differences between the magnitude of the velocity vectors and angles between the velocity vectors in corresponding voxels. Qualitative analysis of the results was executed by visual inspection and comparison of the flow patterns. The root-mean-square errors of the velocity magnitude in the comparison between phase contrast MRI and computational fluid dynamics were 5% and 4% of the maximum phase contrast MRI velocity, and the medians of the angle distribution between corresponding velocity vectors were 16° and 14° for the steady and pulsatile measurements, respectively. In the phase contrast MRI and particle image velocimetry comparison, the root-mean-square errors were 12% and 10% of the maximum phase contrast MRI velocity, and the medians of the angle distribution between corresponding velocity vectors were 19° and 15° for the steady and pulsatile measurements, respectively. Good agreement was found in the qualitative comparison of flow patterns between the phase contrast MRI measurements and both particle image velocimetry measurements and computational fluid dynamics simulations. High-resolution, time-resolved, three-dimensional phase contrast MRI can accurately measure complex flow patterns in an intracranial aneurysm phantom.
authors.affiliation: Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. pim.vanooij@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: van Ooij
authors.forename: A
authors.initials: A
authors.lastname: Guédon
authors.forename: C
authors.initials: C
authors.lastname: Poelma
authors.forename: J
authors.initials: J
authors.lastname: Schneiders
authors.forename: M C M
authors.initials: MC
authors.lastname: Rutten
authors.forename: H A
authors.initials: HA
authors.lastname: Marquering
authors.forename: C B
authors.initials: CB
authors.lastname: Majoie
authors.forename: E
authors.initials: E
authors.lastname: VanBavel
authors.forename: A J
authors.initials: AJ
authors.lastname: Nederveen
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D003287:Contrast Media; D057446:Hydrodynamics; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D019047:Phantoms, Imaging; D011673:Pulsatile Flow / Q000502:physiology; D051381:Rats; D015203:Reproducibility of Results; D012212:Rheology / Q000379:methods*
chemical_list: D003287:Contrast Media