title: Natriuretic peptide system: an overview of studies using genetically engineered animal models.
abstract: The mammalian natriuretic peptide system, consisting of at least three ligands and three receptors, plays critical roles in health and disease. Examination of genetically engineered animal models has suggested the significance of the natriuretic peptide system in cardiovascular, renal and skeletal homeostasis. The present review focuses on the in vivo roles of the natriuretic peptide system as demonstrated in transgenic and knockout animal models.
authors.affiliation: Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan. kishimot@ri.ncvc.go.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kishimoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tokudome
authors.forename: Kazuwa
authors.initials: K
authors.lastname: Nakao
authors.forename: Kenji
authors.initials: K
authors.lastname: Kangawa
mesh_terms: D000818:Animals; D005818:Genetic Engineering; D023421:Models, Animal; D045265:Natriuretic Peptides / Q000235:genetics / Q000502:physiology*
chemical_list: D045265:Natriuretic Peptides