title: How does neuromodulation work.
abstract: Although sacral neuromodulation (SNM) is approved and successfully used for different urological and proctologic functional diseases for the long-term treatment, less is known about the working mechanisms underlying SNM. This review highlights SNM clinical application, the current data of LUT neuroanatomy and neurophysiology, SNM techniques and its prospective working mechanisms. Functional imaging techniques have facilitated a more detailed insight into the neural network between the central nervous system (CNS) and the lower urinary tract (LUT). In addition to the well-known factors of the spinal micturition pathway, several pontine (e.g. pontine micturition centre) and suprapontine (e.g. cingulate cortex) regions and their interactions have been identified. An attribution of CNS activity levels to different LUT conditions is possible for the first time. Based on this information, different SNM actions could also have been allocated to different ascending/descending pathways and supraspinal regions, whereas acute SNM especially affects regions of learning activity, chronic SNM might result in CNS plasticity even though clinical effectiveness fades after SNM deactivation. Studies to treat fecal incontinence or to prevent detrusor overactivity in complete spinal cord injured patients support the importance of sympathetic pathways for the action of SNM. Despite increasing knowledge about SNM influence on the CNS, the complexity of its underlying working mechanisms is not understood at all. Further investigations with improved functional imaging techniques will enhance our SNM background.
authors.affiliation: Department of Urology, Eberhard Karl University of Tuebingen, Tuebingen, Germany.
authors.forename: Bastian
authors.initials: B
authors.lastname: Amend
authors.forename: Klaus E
authors.initials: KE
authors.lastname: Matzel
authors.forename: Paul
authors.initials: P
authors.lastname: Abrams
authors.forename: William C
authors.initials: WC
authors.lastname: de Groat
authors.forename: Karl-Dietrich
authors.initials: KD
authors.lastname: Sievert
mesh_terms: D002490:Central Nervous System / Q000503:physiopathology; D004599:Electric Stimulation Therapy; D019317:Evidence-Based Medicine; D005242:Fecal Incontinence / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D008160:Lumbosacral Plexus / Q000503:physiopathology*; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D009473:Neuronal Plasticity; D012018:Reflex; D013997:Time Factors; D016896:Treatment Outcome; D014551:Urinary Tract / Q000294:innervation*; D014570:Urologic Diseases / Q000503:physiopathology / Q000628:therapy*