title: Antituberculosis cycloartane triterpenoids from Radermachera boniana.
abstract: Three new triterpenoids, bonianic acids A (1) and B (2) and 3-O-acetyluncaric acid (3), were isolated from the leaves and twigs of Radermachera boniana, together with six known compounds, ursolic acid (4), oleanolic acid (5), 3-epi-oleanolic acid (6), 3α-O-acetyl-α-boswellic acid (7), ergosterol peroxide (8), and β-sitostenone (9). Ergosterol peroxide (8) and bonianic acids A (1) and B (2) exhibited significant activity against Mycobacterium tuberculosis H37Rv strain.
authors.affiliation: Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay, Hanoi, Vietnam.
authors.forename: Ngan B
authors.initials: NB
authors.lastname: Truong
authors.forename: Cuong V
authors.initials: CV
authors.lastname: Pham
authors.forename: Huong T M
authors.initials: HT
authors.lastname: Doan
authors.forename: Hung V
authors.initials: HV
authors.lastname: Nguyen
authors.forename: Cuong M
authors.initials: CM
authors.lastname: Nguyen
authors.forename: Hiep T
authors.initials: HT
authors.lastname: Nguyen
authors.forename: Hong-jie
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Harry H S
authors.initials: HH
authors.lastname: Fong
authors.forename: Scott G
authors.initials: SG
authors.lastname: Franzblau
authors.forename: Djaja D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: Minh V
authors.initials: MV
authors.lastname: Chau
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029402:Bignoniaceae / Q000737:chemistry*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000097245:Ursolic Acid
chemical_list: D000995:Antitubercular Agents; D014315:Triterpenes; D000097245:Ursolic Acid; C560317:3-O-acetyluncaric acid; C560315:bonianic acid A; C560316:bonianic acid B; C085352:cycloartane