title: Relapsing herpes simplex encephalitis resulting in Kluver-Bucy syndrome.
abstract: Relapsing herpes simplex encephalitis (HSE) rarely occurs after acyclovir treatment. We treated a patient with relapsing HSE of the contralateral temporal lobe, resulting in Klüver-Bucy syndrome, after a full-dose acyclovir treatment. This case suggests that physicians should consider sudden behavioral and emotional changes after HSE treatment as a possible indication of relapsing HSE, as well as possible temporal lobe epilepsy, and the need to administer longer acyclovir treatment for select patients.
authors.affiliation: Department of Neurology, Myongji Hospital, Kwandong University College of Medicine, Republic of Korea.
authors.forename: Bon D
authors.initials: BD
authors.lastname: Ku
authors.forename: Sung Sang
authors.initials: SS
authors.lastname: Yoon
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D020803:Encephalitis, Herpes Simplex / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D020232:Kluver-Bucy Syndrome / Q000175:diagnosis* / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir