title: [IEX-1: an unique protein in regulating apoptosis].
abstract: Immediate early response gene X-1 (IEX-1) gene was discovered by Charles in 1993, which plays an important role in regulating apoptosis. Previous studies demonstrated that IEX-1 gene was expressed in a variety of human tissues and played an important role in regulating apoptosis and cell growth through a positive or negative way. It can inhibit cell growth and apoptosis. However, it can also promote cell apoptosis. There is evidence that IEX-1 is involved in viral infections and cardiovascular diseases and it is highly expressed in many tumor tissues. The regulatory mechanisms for IEX-1 under normal and pathophysiological conditions are complicated and remain largely unknown. In this paper, we reviewed the recent progress of IEX-1 in different disease models.
authors.affiliation: Institute of Osteocarcinoma, Second Xiangya Hospital, Central South University, Changsha 410011,China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Wu
authors.initials: W
authors.lastname: Zhu
authors.forename: Tao
authors.initials: T
authors.lastname: Xiao
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics* / Q000502:physiology*; D049109:Cell Proliferation; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012516:Osteosarcoma / Q000378:metabolism / Q000473:pathology
chemical_list: D051017:Apoptosis Regulatory Proteins; C099815:IER3 protein, human; D008565:Membrane Proteins