title: [Effects of agonist and antagonist of cysteinyl leukotriene receptors on differentiation of rat glioma C6 cells].
abstract: To investigate the role of cysteinyl leukotriene (CysLT) receptors in the differentiation of rat glioma C6 cells.
  
  
  
  Rat glioma C6 cells were treated with the agonist LTD(4), the CysLT(1) receptor antagonist montelukast and the differentiation inducer forskolin. Cell morphology and GFAP protein expression were determined after treatments.
  
  
  
  Forskolin (10 μmol/L) induced morphological changes and GFAP protein expression (cell differentiation) in C6 cells, but LTD(4) (0.1-100 nmol/L) did not induce these changes. Montelukast (1 μmol/L) alone did not affect C6 cell differentiation, while it induced the differentiation when combined with the LTD(4) (100 nmol/L).
  
  
  
  The CysLT(2) receptor may modulate the differentiation of rat glioma C6 cells.
authors.affiliation: Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
authors.forename: Bei-Lei
authors.initials: BL
authors.lastname: Cai
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Wang
authors.forename: Shu-Ying
authors.initials: SY
authors.lastname: Yu
authors.forename: Xue-Qin
authors.initials: XQ
authors.lastname: Huang
authors.forename: Xia-Yan
authors.initials: XY
authors.lastname: Zhang
authors.forename: San-Hua
authors.initials: SH
authors.lastname: Fang
authors.forename: Yun-Bi
authors.initials: YB
authors.lastname: Lu
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Zhang
authors.forename: Er-Qing
authors.initials: EQ
authors.lastname: Wei
mesh_terms: D000085:Acetates / Q000494:pharmacology; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D005576:Colforsin / Q000494:pharmacology; D003521:Cyclopropanes; D003545:Cysteine; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D020024:Leukotriene Antagonists / Q000494:pharmacology*; D017998:Leukotriene D4 / Q000494:pharmacology; D015289:Leukotrienes; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D018077:Receptors, Leukotriene / Q000819:agonists*; D013440:Sulfides
chemical_list: D000085:Acetates; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D015289:Leukotrienes; D011804:Quinolines; D018077:Receptors, Leukotriene; D013440:Sulfides; C112381:cysteinyl-leukotriene; D005576:Colforsin; D017998:Leukotriene D4; D003545:Cysteine; C093875:montelukast