title: Palladium-catalyzed C-H bond functionalization of C6-arylpurines.
abstract: A highly regioselective Pd-catalyzed C(Ar)-H bond activation method was developed for the modification of purines (nucleosides) with different functional groups by using purine as a directing group. This approach provides a new access to a variety of functionalized purines (nucleosides) which are potentially of great importance in medicinal chemistry.
authors.affiliation: College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang 453007, Henan, China. guohm518@hotmail.com
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
authors.forename: Wei-Hao
authors.initials: WH
authors.lastname: Rao
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Niu
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Jiang
authors.forename: Ge
authors.initials: G
authors.lastname: Meng
authors.forename: Jia-Jia
authors.initials: JJ
authors.lastname: Jin
authors.forename: Xi-Ning
authors.initials: XN
authors.lastname: Yang
authors.forename: Gui-Rong
authors.initials: GR
authors.lastname: Qu
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011687:Purines / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D011687:Purines; D010165:Palladium; D002244:Carbon; D006859:Hydrogen