title: A single bout of exercise promotes sustained left ventricular function improvement after isoproterenol-induced injury in mice.
abstract: We have investigated whether acute (swimming) exercise is sufficient to have sustained beneficial effects against cardiac functional decline observed after high-dose isoproterenol administration. Mice were subjected to one bout of swimming for 30 min ("swim" group). Twenty-four hours later, they were given isoproterenol (160 mg/kg) to cause injury. Two control groups were included, a shallow "water" group, for which no swimming took place, and a "cage" group; they were both given isoproterenol as in the "swim" group. Cardiac function was assessed by tissue Doppler imaging (TDI) 24 h, 2 weeks, and 4 weeks post-isoproterenol. Left ventricular (LV) systolic function including endocardial velocity and radial strain rate declined significantly in all groups at all time points after isoproterenol, compared with their pre-isoproterenol treatment values. The "swim" group, however, had significantly higher LV systolic function compared with either of the control groups at 24 h, and this improvement persisted 2 and 4 weeks post-treatment. There were no significant differences between the control groups at any time point. In conclusion, a single bout of swimming has sustained beneficial effects against injury, as measured by TDI, after administration of isoproterenol.
authors.affiliation: Department of Physiology, University of Manitoba, Winnipeg, Canada.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Jimenez
authors.forename: Davinder S
authors.initials: DS
authors.lastname: Jassal
authors.forename: Elissavet
authors.initials: E
authors.lastname: Kardami
authors.forename: Peter A
authors.initials: PA
authors.lastname: Cattini
mesh_terms: D000818:Animals; D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006335:Heart Injuries / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009206:Myocardium / Q000473:pathology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D013550:Swimming / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D007545:Isoproterenol