title: [Pathology of neuroendocrine neoplasms].
abstract: During the last 5 years the European Neuroendocrine Tumor Society (ENETS) has developed basic recommendations for a standardized pathological diagnosis and classification of neuroendocrine neoplasms (NEN) of the gastroenteropancreatic system. These were included in the novel classification of tumors of the digestive system by the World Health Organization (WHO 2010) and the TNM classification of the union for international cancer control (2009). This review presents the pathology diagnosis regarding (1) basic diagnosis, (2) clinically relevant optional diagnosis, (3) proliferation-based grading, (4) nomenclature and (5) TNM classification. It is emphasized that a standardized diagnosis of NEN, together with clinical and radiological findings, is crucial for prognostic stratification and optimal therapy of patients with NEN. Therefore a close interdisciplinary collaboration is essential.
authors.affiliation: Institut für Pathologie, Endokrines Tumorzentrum am Universitätsklinikum Düsseldorf, Moorenstrasse 5, Düsseldorf, Germany. martin.anlauf@med.uni-duesseldorf.de
authors.forename: M
authors.initials: M
authors.lastname: Anlauf
authors.forename: P
authors.initials: P
authors.lastname: Gerlach
authors.forename: M
authors.initials: M
authors.lastname: Schott
authors.forename: A
authors.initials: A
authors.lastname: Raffel
authors.forename: M
authors.initials: M
authors.lastname: Krausch
authors.forename: W T
authors.initials: WT
authors.lastname: Knoefel
authors.forename: M
authors.initials: M
authors.lastname: Pavel
authors.forename: G
authors.initials: G
authors.lastname: Klöppel
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D049109:Cell Proliferation; D004067:Digestive System Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000145:classification / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D009626:Terminology as Topic
chemical_list: D014408:Biomarkers, Tumor