title: Association study of the β2-adrenergic receptor gene polymorphisms and hypertension in the Northern Han Chinese.
abstract: BACKGROUND
  The β2-adrenergic receptor (ADRB2) gene has been widely researched as a candidate gene for essential hypertension (EH), but no consensus has been reached in different ethnicities. The aim of the present study was to evaluate the possible association between the ADRB2 gene polymorphisms and the EH risk in the Northern Han Chinese population.
  
  
  RESULTS
  This study included 747 hypertensive subjects and 390 healthy volunteers as control subjects in the Northern Han Chinese. Genotyping was performed to identify the C-47T, A46G and C79G polymorphisms of the ADRB2 gene. G allelic frequency of A46G polymorphism was significantly higher in hypertensive subjects (P = 0.011, OR = 1.287, 95%CI [1.059-1.565]) than that in controls. Significant association could also be found in dominant genetic model (GG+AG vs. AA, P = 0.006, OR = 1.497, 95%CI [1.121-1.998]), in homozygote comparison (GG vs. AA, P = 0.025, OR = 1.568, 95%CI [1.059-2.322]), and in additive genetic model (GG vs. AG vs. AA, P = 0.012, OR = 1.282, 95%CI [1.056-1.555]). Subgroup analyses performed by gender suggested that this association could be found in male, but not in female. Stratification analyses by obesity showed that A46G polymorphism was related to the prevalence of hypertension in the obese population (GG vs. AG vs. AA, P<0.001, OR = 1.645, 95%CI [1.258-2.151]). Significant interaction was found between A46G genotypes and body mass index on EH risk. No significant association could be found between C-47T or C79G polymorphism and EH risk. Linkage disequilibrium was detected between the C-47T, A46G and C79G polymorphisms. Haplotype analyses observed that the T-47-A46-C79 haplotype was a protective haplotype for EH, while the T-47-G46-C79 haplotype increased the risk.
  
  
  CONCLUSIONS
  We revealed that the ADRB2 A46G polymorphism might increase the risk for EH in the Northern Han Chinese population.
authors.affiliation: Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, People's Republic of China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Lou
authors.forename: Jielin
authors.initials: J
authors.lastname: Liu
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.forename: Zuoguang
authors.initials: Z
authors.lastname: Wang
authors.forename: Kuo
authors.initials: K
authors.lastname: Liu
authors.forename: Hai
authors.initials: H
authors.lastname: Wu
authors.forename: Qiuli
authors.initials: Q
authors.lastname: Niu
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Guo
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Li
authors.forename: Shaojun
authors.initials: S
authors.lastname: Wen
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
chemical_list: C553443:ADRB2 protein, human; D018343:Receptors, Adrenergic, beta-2