title: Brain changes may develop early in people with Alzheimer's risk marker.  Changes in brain activity appear to occur before amyloid plaques emerge in people with a form of the APOE4 gene.
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D053327:Apolipoprotein E4 / Q000235:genetics; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D005819:Genetic Markers; D006801:Humans
chemical_list: D053327:Apolipoprotein E4; D005819:Genetic Markers