title: Progressive parkinsonism, oculomotor abnormalities and autonomic dysfunction: clinicopathological case.
abstract: A 59-year-old woman presented with asymmetric parkinsonism that was not-responsive to Levodopa therapy. She developed early falls, postural instability, and moderately severe autonomic dysfunction. Eye movement abnormalities were reported 2 years after her first symptoms, and she eventually developed anterocollis. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.
authors.affiliation: Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fabbrini
authors.forename: Marcello
authors.initials: M
authors.lastname: Merello
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Evans
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lees
authors.forename: Janice
authors.initials: J
authors.lastname: Holton
authors.forename: David R
authors.initials: DR
authors.lastname: Williams
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000150:complications* / Q000473:pathology; D020734:Parkinsonian Disorders / Q000150:complications* / Q000473:pathology; D011699:Putamen / Q000473:pathology