title: [Synthesis of thienopyridine derivatives and its anti-platelet activity in vivo].
abstract: To explore novel ADP receptor inhibitors with anti-thrombotic activity, eighteen compounds were synthesized and their structures were confirmed by 1H NMR and MS. The results showed that the activity of compound C1 was superior to ticlopidine in platelet aggregation inhibition tests in vivo and worthy for further investigation. Compounds A4, B2, C4 and C7 possessed moderate platelet aggregation inhibitory activities.
authors.affiliation: Graduate School, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Yun-Song
authors.initials: YS
authors.lastname: Zhou
authors.forename: Ping-Bao
authors.initials: PB
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Ji-Fang
authors.initials: JF
authors.lastname: Chen
authors.forename: Nan
authors.initials: N
authors.lastname: Yue
authors.forename: Deng-Ke
authors.initials: DK
authors.lastname: Liu
mesh_terms: D000818:Animals; D008297:Male; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D058921:Purinergic P2Y Receptor Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D058924:Thienopyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D058924:Thienopyridines