title: [Targeted inactivation of gamma-synuclein gene affects anxiety and exploratory behaviour of mice].
abstract: Gamma(gamma)-synuclein is a member of synuclein family of cytoplasmic and predominantly neuronal proteins found only in vertebrates. Gamma-synuclein is abundant in axons and presynaptic terminals of neurons localized in brain regions involved in emotions, learning and memory. However, the role of gamma-synuclein in these brain functions was not previously assessed. We have demonstrated for the first time that the loss of gamma-synuclein results in a significant increase in the level of orientation response in novel environment and decrease in the level of state anxiety.
authors.forename: V S
authors.initials: VS
authors.lastname: Kokhan
authors.forename: A V
authors.initials: AV
authors.lastname: Bolkunov
authors.forename: A A
authors.initials: AA
authors.lastname: Ustiugov
authors.forename: G I
authors.initials: GI
authors.lastname: Van'kin
authors.forename: T A
authors.initials: TA
authors.lastname: Shelkovnikova
authors.forename: O M
authors.initials: OM
authors.lastname: Redkozubova
authors.forename: T V
authors.initials: TV
authors.lastname: Strekalova
authors.forename: V L
authors.initials: VL
authors.lastname: Bukhman
authors.forename: N N
authors.initials: NN
authors.lastname: Ninkina
authors.forename: S O
authors.initials: SO
authors.lastname: Bachurin
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000523:psychology*; D005106:Exploratory Behavior; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D051845:gamma-Synuclein / Q000235:genetics / Q000502:physiology*
chemical_list: D051845:gamma-Synuclein