title: Novel mast cell-stabilising amine derivatives of 3,4 dihydronaphthalen-1(2H)-one and 6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one.
abstract: In an investigation of 4-amino-3,4-dihydronaphthalen-1(2H)-ones as novel modulators of allergic and inflammatory phenomena, we have investigated a series of cyclic analogues. Tertiary amines of structural types 9, 10, 20 and 21 were synthesised and evaluated for mast cell stabilising activity. In vitro and in vivo studies showed that of these compounds, the cyclohexenylamino derivatives of tetralone and benzosuberone of series 20 and 21 exhibited interesting activity both in vitro and in vivo.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, University of Dublin, Trinity College, Ireland.
authors.forename: James W
authors.initials: JW
authors.lastname: Barlow
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Orla
authors.initials: O
authors.lastname: Woods
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Byrne
authors.forename: John J
authors.initials: JJ
authors.lastname: Walsh
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D018926:Anti-Allergic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: C568112:3,4 dihydronaphthalen-1(2H)-one; C568218:6,7,8,9-tetrahydro-5H-benzo(7)annulen-5-one; D000588:Amines; D018926:Anti-Allergic Agents; D001643:Bridged Bicyclo Compounds; D009281:Naphthalenes