title: [Evolutionary-biological peculiarities of transglutaminase. Structure, physiological functions, application].
abstract: Transglutaminasc (protein-glutamine gamma-glutamyltransferase, EC 2.3.2.13, TG) catalyzes reactions of the acyl transfer, which introduce the epsilon-(gamma-glutamyl)lysine bonds between proteins to create polymers of high mol. mass. Properties of the TG enzyme are described. Its structure is considered: there are characterized items of the TG life cycle and stability, its biological (physiological) role, and significance in pathology and medicine as well as obtaining of the purified enzyme preparations and their use. There are compared TG from different sources: of animal and microbial origin. Mechanism of catalysis of microbial TG is discussed. There are presented characteristics of isoenzymes from different biological sources.
authors.forename: A G
authors.initials: AG
authors.lastname: Shleĭkin
authors.forename: N P
authors.initials: NP
authors.lastname: Danilov
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology; D005075:Biological Evolution; D002384:Catalysis; D002446:Celiac Disease / Q000201:enzymology; D049109:Cell Proliferation; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000201:enzymology; D019636:Neurodegenerative Diseases / Q000201:enzymology; D010944:Plants / Q000201:enzymology; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D013379:Substrate Specificity; D011503:Transglutaminases / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D011503:Transglutaminases