title: [The role of ADME evaluation in translation research of innovative drug].
abstract: New Chemical Entities (NCEs) development is a systematic long-term project that involves multiple disciplines. The translation research will help to build an advanced R&D system from the basic laboratory research, preclinical studies and clinical evaluation to clinical application of drug, for the purpose of shortening the R&D cycle and accelerate the launch of new drugs. In new drug R&D and its clinical application, drug disposition (absorption, distribution, metabolism, excretion, ADME) properties are important criteria for assessing drug-likeness of candidates. ADME evaluation of NCEs plays an important role in the translation research throughout innovative drug R&D process. Therefore, ADME evaluation at the early stage of drug design and development will be helpful to improve the success rate and reduce costs, and further access to safe, effective drugs.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Liu
authors.forename: Lan
authors.initials: L
authors.lastname: Hong
authors.forename: Lu-Shan
authors.initials: LS
authors.lastname: Yu
authors.forename: Hui-Di
authors.initials: HD
authors.lastname: Jiang
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Chen
authors.forename: Qin
authors.initials: Q
authors.lastname: Meng
authors.forename: Shu-Qing
authors.initials: SQ
authors.lastname: Chen
authors.forename: Su
authors.initials: S
authors.lastname: Zeng
mesh_terms: D000042:Absorption; D001692:Biological Transport; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D010599:Pharmacokinetics; D014018:Tissue Distribution; D057170:Translational Research, Biomedical
chemical_list: D004364:Pharmaceutical Preparations