title: Echocardiographic estimation of left atrial pressure in beagle dogs with experimentally-induced mitral valve regurgitation.
abstract: Non-invasive and immediate estimation of left atrial pressure (LAP) is very useful for the management of mitral regurgitation (MR), and many reports have assessed echocardiographic estimations of LAP to date. However, it has been unclear of which examination and evaluate article possess the best accuracy for the MR severity. The present research aims to establish the echocardiographic estimation equation of LAP that is well applicable for clinical MR dogs. After the chordae tendineae rupture was experimentally induced via left atriotomy in six healthy beagle dogs (three males and three females, two years old, weighing between 9.8 to 12.8 kg), a radio telemetry transmitter catheter was inserted, which allows the continuous recordings of LAP without the use of sedation. Approximately 5 weeks after the surgery, echocardiographic examination, indirect blood pressure measurement, measurement of plasma atrial natriuretic peptide (ANP) and LAP measurement by way of the radio telemetry system was performed simultaneously. Subsequently, simple linear regression equations between LAP and each variable were obtained, and the equations were evaluated whether to be applicable for clinical MR dogs. As a result, the ratio of early diastolic mitral flow to early diastolic lateral mitral annulus velocity (E/Ea) had the strongest correlation as maximum LAP=7.03*(E/Ea)-54.86 (r=0.74), and as mean LAP=4.94*(E/Ea)-40.37 (r=0.70) among the all variables. Therefore, these two equations associated with E/Ea should bring more precise and instant estimations of maximum and mean LAP in clinical MR dogs.
authors.affiliation: Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan. taisuke@vet.ne.jp
authors.forename: Taisuke
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Ryuji
authors.initials: R
authors.lastname: Fukushima
authors.forename: Shuji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Miyaishi
authors.forename: Taiki
authors.initials: T
authors.lastname: Nishimura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hira
authors.forename: Lina
authors.initials: L
authors.lastname: Hamabe
authors.forename: Ryou
authors.initials: R
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D016279:Atrial Function, Left; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure; D004283:Dog Diseases / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004285:Dogs; D015150:Echocardiography, Doppler; D005260:Female; D016014:Linear Models; D008297:Male; D008944:Mitral Valve Insufficiency / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D013686:Telemetry / Q000662:veterinary
chemical_list: D009320:Atrial Natriuretic Factor