title: Risk factors for squamous cell carcinoma of the skin with two illustrative cases and literature review.
abstract: Non-melanoma skin cancers, including basal cell carcinoma and squamous cell carcinoma are most frequently observed neoplasms worldwide. Their incidence has steadily been growing. Cutaneous squamous cell carcinoma is more common than basal cell carcinoma in dark complexion individuals. Every year, more than one million new cases of non-melanoma skin cancers (NMSC) are identified in the United States, which is roughly estimated to account for 50% of all cancers in this country. In this article, two illustrative cases are presented, which demonstrate the risk factors for cutaneous squamous cell carcinoma development, emphasizing the relationships and synergistic interactions in the process of carcinogenesis.
authors.affiliation: Department of Dermatology, Military Institute of Health Services, Warsaw, Poland.
authors.forename: Witold
authors.initials: W
authors.lastname: Owczarek
authors.forename: Sebastian
authors.initials: S
authors.lastname: Majewski
authors.forename: Robert A
authors.initials: RA
authors.lastname: Schwartz
mesh_terms: D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008875:Middle Aged; D009367:Neoplasm Staging; D011044:Poland / Q000453:epidemiology; D011379:Prognosis; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D016019:Survival Analysis; D016896:Treatment Outcome; D014466:Ultraviolet Rays / Q000009:adverse effects