title: Controlling biofilm with evidence-based dentifrices.
abstract: This review summarizes research that has assessed the effectiveness of various antimicrobial-containing dentifrices in preventing and/or reducing a number of oral health problems facing our patients today. The results of these studies indicate that, when compared with a conventional fluoride dentifrice, the triclosan/copolymer/fluoride dentifrice is the one with the most evidence to support its ability to deliver significant oral health benefits with no adverse effects. The benefits maybe summarized as follows: improved levels ofsupragingival plaque control; improved gingival health; reducedlikelihood of gingivitis progressing to periodontitis; arrest progression of periodontitis; prevention of supragingival calculus; and reduction in oral malodor. With increased interest in the association of oral health with systemic health, this dentifrice is well-positioned to help reduce the likelihood of gingivitis establishing itself and possibly developing into periodontitis (Figure 1). It also has the potential to have beneficial effects on general health because of its anti-inflammatory properties. Based on the results presented in this article, it is clear that the general population can derive significant clinical benefits from the daily use of a triclosan/copolymer/fluoride dentifrice. The dental profession should feel confident to recommend its use to patients to improve oral health and maintain or promote overall health.
authors.affiliation: Department of Periodontics and Endodontics, State University of New York (SUNY) at Buffalo, Buffalo, New York, USA.
authors.forename: Sebastian G
authors.initials: SG
authors.lastname: Ciancio
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002712:Chlorides / Q000627:therapeutic use; D003731:Dental Caries / Q000628:therapy; D003773:Dental Plaque / Q000628:therapy*; D003802:Dentifrices / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008298:Maleates / Q000627:therapeutic use*; D010518:Periodontitis / Q000628:therapy*; D011095:Polyethylenes / Q000627:therapeutic use*; D012824:Silicic Acid / Q000627:therapeutic use; D014002:Tin Fluorides / Q000627:therapeutic use; D014100:Toothpastes / Q000627:therapeutic use; D014260:Triclosan / Q000627:therapeutic use*; D017967:Zinc Compounds / Q000627:therapeutic use
chemical_list: D000891:Anti-Infective Agents, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002712:Chlorides; D003802:Dentifrices; D004338:Drug Combinations; D008298:Maleates; D011095:Polyethylenes; D014002:Tin Fluorides; D014100:Toothpastes; D017967:Zinc Compounds; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D014260:Triclosan; C016837:zinc chloride; C043105:poly(methyl vinyl ether-co-maleic anhydride)