title: HIV transmission: time for translational studies to bridge the gap.
abstract: More than 7000 new HIV infections are documented each day worldwide. In this Perspective, we dissect new results from a large clinical trial showing that genital and plasma HIV-1 RNA loads predict the risk of heterosexual transmission and that genital tract viral RNA load does so independently of plasma viral load. Furthermore, beyond its defined study end points, this well-conducted trial identified new research directions that should be pursued in smaller intensive basic and translational studies.
authors.affiliation: Center for HIV Prevention Research, Division of Digestive Diseases and UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. PAnton@mednet.ucla.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Anton
authors.forename: Betsy C
authors.initials: BC
authors.lastname: Herold
mesh_terms: D005260:Female; D005836:Genitalia, Female / Q000821:virology; D015658:HIV Infections / Q000635:transmission*; D020010:Heterosexuality / Q000502:physiology; D006801:Humans; D008297:Male