title: Expression and distribution of S-100, CD83, and costimulatory molecules (CD80 and CD86) in tissues of thyroid papillary carcinoma.
abstract: A higher expression of S-100 in tissue of thyroid papillary carcinoma (TPC) vs. thyroid follicular adenoma (TFA) (p < .001) was observed as well as a higher expression of CD83 in the peri-cancerous tissues vs. TFA (p < .001), oppositely, CD83 was negative in the cancerous net. TPC showed greater decreases in levels of CD80 and CD86 than did the TFA. These findings suggest that impaired immune function, absence of CD83-positive mature and activated dendritic cells in cancer nodules may have a role in the pathogenesis of TPC. The low expression of CD80 and CD86 in TPC may help them evade the immune system.
authors.affiliation: The First Affilaited Hospital of Shantou University Medical School, China. xuwcan@163.com
authors.forename: Wen-Can
authors.initials: WC
authors.lastname: Xu
authors.forename: Zheng-Bing
authors.initials: ZB
authors.lastname: Li
authors.forename: Yong-Ru
authors.initials: YR
authors.lastname: Chen
authors.forename: Xi-Tao
authors.initials: XT
authors.lastname: Li
authors.forename: Jie-Xiong
authors.initials: JX
authors.lastname: Huang
authors.forename: Yu-Guang
authors.initials: YG
authors.lastname: Li
authors.forename: Shen-Ren
authors.initials: SR
authors.lastname: Chen
mesh_terms: D000236:Adenoma / Q000276:immunology*; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D018122:B7-1 Antigen / Q000378:metabolism*; D051940:B7-2 Antigen / Q000378:metabolism*; D002277:Carcinoma; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009418:S100 Proteins / Q000378:metabolism*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000276:immunology; D013997:Time Factors; D019139:Tumor Escape; D000097802:CD83 Antigen
chemical_list: D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D009418:S100 Proteins; D000097802:CD83 Antigen; C497964:CD86 protein, human