title: [TRAIL gene polymorphism and genetic susceptibility to prostate cancer in the Chinese Han population of Nanjing].
abstract: OBJECTIVE
  To investigate the correlation between the polymorphism of the tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and the genetic susceptibility to prostate cancer (PCa) in the Chinese Han population in Nanjing.
  
  
  METHODS
  We performed a case control study on 187 cases of PCa and 237 cancer-free healthy controls. Peripheral blood genome DNA was extracted from the subjects for analysis of the polymorphism of the TRAIL-716 locus by polymerase chain reaction-ligase detection reaction (PCR-LDR). The correlations between the susceptibility to PCa and different genotypes were compared.
  
  
  RESULTS
  An SNP (-716A/G) was found in the promoter of the TRAIL gene. AA, AG and GG genotypes were identified. Logistic regression analysis suggested that AG, GG and AG + GG genotypes had no significant correlation with the risk of PCa (OR = 0.89, 95% CI = 0.54 -1.47; OR = 0.94, 95% CI = 0.69 -1.27; OR = 0.87, 95% CI = 0.54 - 1.41).
  
  
  CONCLUSIONS
  The TRAIL-716 polymorphism is not directly related with the genetic susceptibility to PCa in the Chinese Han population of Nanjing.
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Mi
authors.forename: Jiu-ming
authors.initials: JM
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Shao
authors.forename: Zhi-chao
authors.initials: ZC
authors.lastname: Min
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Hua
authors.forename: Ning-han
authors.initials: NH
authors.lastname: Feng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics*
chemical_list: D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human