title: [Controversy in the treatment of acid-base abnormalities].
abstract: Sodium bicarbonate has been standard therapy for the treatment of acidosis. In lactic acidosis and hypercapnic acidosis, however, there is no clinical data supporting its effectiveness. We reviewed the literature of the efficacy of sodium bicarbonate on lactic acidosis and hypercapnic acidosis. On both conditions, we have no solid evidence supporting its beneficial effect. Conversely, acidosis or hypercapnia might be protective in acute lung and systemic organ injury. Therefore, the unprepared use of bicarbonate might be harmful in terms of fluid and sodium overload and excess lactate concentrations. According to current literature, we cannot recommend sodium bicarbonate administration for patients with lactic acidosis and hypercapnic acidosis.
authors.affiliation: Department of Anesthesia and Perioperative Medicine, Kobe University Hospital Anesthesiology, Kobe 650-0017.
authors.forename: Mayu
authors.initials: M
authors.lastname: Ooi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Maekawa
mesh_terms: D000137:Acid-Base Imbalance / Q000188:drug therapy*; D000138:Acidosis / Q000188:drug therapy; D019317:Evidence-Based Medicine; D006801:Humans; D006935:Hypercapnia / Q000188:drug therapy; D017693:Sodium Bicarbonate / Q000009:adverse effects*
chemical_list: D017693:Sodium Bicarbonate