title: Adult stem cells and bioengineering strategies for the treatment of cerebral ischemic stroke.
abstract: The adult central nervous system (CNS) contains a population of neural stem cells, yet unlike many other tissues, has a very limited capacity for self-repair. Promoting tissue repair and functional recovery following CNS injury or disease is a high priority as there are currently no effective treatments towards this end for the treatment of disorders such as stroke, traumatic brain injury and spinal cord injury. Recent advances in stem cell biology have offered a number of enticing potential avenues and we will discuss these possibilities along with the associated challenges as they pertain to stroke. We will consider exogenous therapies involving the transplantation of adult stem cells, and the mobilization of endogenous stem cells, as well as drug delivery and tissue engineering strategies that enhance and complement the cell based strategies.
authors.affiliation: Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore.
authors.forename: Fenggang
authors.initials: F
authors.lastname: Yu
authors.forename: Cindi M
authors.initials: CM
authors.lastname: Morshead
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology / Q000637:transplantation*; D000818:Animals; D057005:Bioengineering; D002544:Cerebral Infarction / Q000503:physiopathology / Q000628:therapy*; D016503:Drug Delivery Systems; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology / Q000637:transplantation; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology / Q000627:therapeutic use; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology; D009416:Nerve Regeneration; D058953:Neural Stem Cells / Q000187:drug effects / Q000502:physiology; D009832:Olfactory Nerve / Q000166:cytology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins