title: Treatment and prophylaxis of invasive candidiasis with anidulafungin, caspofungin and micafungin:review of the literature.
abstract: Working by a distinct cell wall-specific mechanism of action, the echinocandin class of antifungals has substantially expanded the range of available treatments for invasive Candida infections. Anidulafungin, caspofungin and micafungin were investigated versus drugs from earlier antifungal classes in large clinical trials that demonstrated their excellent clinical and microbiological efficacy in the primary treatment of invasive candidiasis. Therefore, and supported by a number of favourable pharmacological characteristics, the echinocandins rapidly became established in guidelines and clinical practice as primary treatment options for moderately to severely ill patients with invasive candidiasis. This article reviews the relevant clinical evidence that forms the basis for the use of echinocandins in the management of invasive candidiasis, and discusses their current role in the context of recent guideline recommendations and treatment optimization strategies.
authors.affiliation: BDH Klinik Greifswald GmbH, Germany. a.gloeckner@bdh-klinik-greifswald.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Glöckner
mesh_terms: D000077612:Anidulafungin; D000935:Antifungal Agents / Q000627:therapeutic use*; D058365:Candidiasis, Invasive / Q000188:drug therapy* / Q000517:prevention & control*; D000077336:Caspofungin; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D054714:Echinocandins / Q000627:therapeutic use*; D017408:Guidelines as Topic; D006801:Humans; D055666:Lipopeptides / Q000627:therapeutic use*; D000077551:Micafungin
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077612:Anidulafungin; D000077336:Caspofungin; D000077551:Micafungin