title: A high-sucrose diet induces fatty liver, but not deterioration of diabetes mellitus in Zucker diabetic fatty rats.
abstract: A high-sucrose diet induces insulin resistance and dyslipidemia in normal rats. The purpose of the present study was to investigate effects of a high-sucrose diet to glycolipid metabolism in Zucker Diabetic Fatty (ZDF) rat. Male ZDF rats were fed with a high-sucrose (68%) diet from 6 to 18 weeks of age. In biochemical analyses, the glucose levels did not change as compared with those in standard diet-fed rats, but the total cholesterol levels were elevated during the experimental period. In pathological analyses, the relative liver weight increased by about 2-fold as compared with that in standard diet-fed rats, and severe fatty change was observed by high-sucrose feeding. A high-sucrose diet induces fatty liver, but not deterioration of diabetes mellitus in ZDF rats. High sucrose-fed rats are considered to be very useful to determine the relationship between hepatic insulin resistance and diabetes mellitus.
authors.affiliation: Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyoku, Kyoto 606-8502, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohta
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Miyajima
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamada
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000209:etiology* / Q000378:metabolism; D019422:Dietary Sucrose / Q000008:administration & dosage* / Q000009:adverse effects*; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000209:etiology / Q000378:metabolism; D005234:Fatty Liver / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D006017:Glycolipids / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D009929:Organ Size; D051381:Rats; D011924:Rats, Zucker
chemical_list: D019422:Dietary Sucrose; D006017:Glycolipids; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase