title: Open-label uridine for treatment of depressed adolescents with bipolar disorder.
abstract: This report is an open-label case series of seven depressed adolescents with bipolar disorder treated with uridine for 6 weeks. Treatment response was measured with the Children's Depression Rating Scale-Revised and the Clinical Global Impressions scale. Uridine was associated with decreased depressive symptoms, and was well tolerated by study participants. Further systematic studies of uridine are warranted.
authors.affiliation: The Brain Institute, University of Utah, Salt Lake City, Utah 84108, USA. doug.kondo@hsc.utah.edu
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Kondo
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Sung
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Hellem
authors.forename: Kristen K
authors.initials: KK
authors.lastname: Delmastro
authors.forename: Eun-Kee
authors.initials: EK
authors.lastname: Jeong
authors.forename: Namkug
authors.initials: N
authors.lastname: Kim
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Shi
authors.forename: Perry F
authors.initials: PF
authors.lastname: Renshaw
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy*; D003863:Depression / Q000188:drug therapy*; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D009705:Nucleosides / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D014529:Uridine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D009705:Nucleosides; D014529:Uridine