title: Development of echinocandin resistance in Clavispora lusitaniae during caspofungin treatment.
abstract: Clavispora lusitaniae is an opportunistic human pathogen responsible for 0.6 to 2% of candidemia. This species is intrinsically susceptible to echinocandins. Nevertheless, in this study, development of echinocandin resistance in C. lusitaniae isolates was observed during caspofungin treatment. This resistance resulted from missense mutation in the echinocandin target Fks1 gene.
authors.affiliation: Institut Pasteur, National Reference Center for Mycoses and Antifungals, Molecular Mycology Unit, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Desnos-Ollivier
authors.forename: Olivier
authors.initials: O
authors.lastname: Moquet
authors.forename: Taieb
authors.initials: T
authors.lastname: Chouaki
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Guérin
authors.forename: Françoise
authors.initials: F
authors.lastname: Dromer
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution / Q000235:genetics; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000077336:Caspofungin; D004252:DNA Mutational Analysis; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000008:administration & dosage / Q000494:pharmacology*; D005964:Glucosyltransferases / Q000235:genetics; D006801:Humans; D055666:Lipopeptides; D008297:Male; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology*; D004718:Saccharomycetales / Q000187:drug effects*; D017422:Sequence Analysis, DNA
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D054714:Echinocandins; D055666:Lipopeptides; D005964:Glucosyltransferases; D000077336:Caspofungin