title: Lipid drug conjugate (LDC) nanoparticles as autolymphotrophs for oral delivery of methotrexate.
abstract: The objective of the study was to develop lipid drug conjugate nanoparticles (LDC-NPs) of anticancer drug methotrexate (MTX) for oral delivery that faces problems of low and variable bioavailability. The MTX loaded LDC-NPs significantly enhanced bioavailability and reduced MTX associated gastrointestinal toxicity even in higher doses recommended for anticancer therapy.
authors.affiliation: Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar 470003, M.P., India.
authors.forename: Rishi
authors.initials: R
authors.lastname: Paliwal
authors.forename: Shivani
authors.initials: S
authors.lastname: Rai
authors.forename: Suresh P
authors.initials: SP
authors.lastname: Vyas
mesh_terms: D000284:Administration, Oral; D000818:Animals; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008055:Lipids / Q000737:chemistry*; D008727:Methotrexate / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D008055:Lipids; D053769:Nanocapsules; D008727:Methotrexate