title: Voltammetric determination of copper in selected pharmaceutical preparations--validation of the method.
abstract: It were established and validated the conditions of voltammetric determination of copper in pharmaceutical preparations. The three selected preparations: Zincuprim (A), Wapń, cynk, miedź z wit. C (B), Vigor complete (V) contained different salts and different quantity of copper (II) and increasing number of accompanied ingredients. For the purpose to transfer copper into solution, the samples of powdered tablets of the first and second preparation were undergone extraction and of the third the mineralization procedures. The concentration of copper in solution was determined by differential pulse voltammetry (DP) using comparison with standard technique. In the validation process, the selectivity, accuracy, precision and linearity of DP determination of copper in three preparations were estimated. Copper was determined within the concentration range of 1-9 ppm (1-9 microg/mL): the mean recoveries approached 102% (A), 100% (B), 102% (V); the relative standard deviations of determinations (RSD) were 0.79-1.59% (A), 0.62-0.85% (B) and 1.68-2.28% (V), respectively. The mean recoveries and the RSDs of determination satisfied the requirements for the analyte concentration at the level 1-10 ppm. The statistical verification confirmed that the tested voltammetric method is suitable for determination of copper in pharmaceutical preparation.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka St., 60-780 Poznań, Poland. alutka@umed.poznan.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Lutka
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Maruszewska
mesh_terms: D003300:Copper / Q000032:analysis*; D019587:Dietary Supplements / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011199:Potentiometry; D011208:Powders; D015203:Reproducibility of Results; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D011208:Powders; D013607:Tablets; D003300:Copper