title: Chemical alignment of DNA origami to block copolymer patterned arrays of 5 nm gold nanoparticles.
abstract: We have used block copolymer patterned arrays of 5 nm gold nanoparticles (AuNPs) for chemically aligned surface attachment of DNA origami. Addition of single-stranded DNA-thiol to AuNPs allowed a base paired attachment of sticky end modified DNA origami. Results indicate a stable, selective attachment between the DNA origami and ssDNA modified AuNPs. Yield data showed 74% of AuNP binding sites forming an attachment with a DNA origami rectangle, and control surfaces showed less than 0.5% nonspecific adsorption.
authors.affiliation: Department of Physics and Astronomy, Brigham Young University, Provo, Utah 84602, United States.
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Pearson
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Pound
authors.forename: Adam T
authors.initials: AT
authors.lastname: Woolley
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Linford
authors.forename: John N
authors.initials: JN
authors.lastname: Harb
authors.forename: Robert C
authors.initials: RC
authors.lastname: Davis
mesh_terms: D000327:Adsorption; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008823:Micelles; D008956:Models, Chemical; D015233:Models, Statistical; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004277:DNA, Single-Stranded; D008823:Micelles; D011108:Polymers; D013438:Sulfhydryl Compounds; D006046:Gold; D004247:DNA