title: Neurovascular coupling in the human somatosensory cortex: a single trial study.
abstract: Oscillations in the higher frequency range are closely related to regional brain hemodynamic changes. Here we investigated this neurovascular coupling in humans in response to electrical stimulation of the right median nerve. In a single-trial study, we simultaneously recorded hemodynamic fluctuations in the somatosensory cortex by near infrared spectroscopy and brain neuronal oscillations by whole-head magnetoencephalography (MEG). The results from six volunteers showed that neural fluctuations at β or γ-band power were correlated with hemodynamic fluctuation during stimulus conditions. These correlations were prominent with a time delay of 5-7 s. This study provides new direct evidence that hemodynamic onset lags specific neural oscillations in the order of seconds in human awake conditions using noninvasive methods.
authors.affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan. mitsuru@zc4.so-net.ne.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Shitamichi
authors.forename: Sanae
authors.initials: S
authors.lastname: Ueno
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoshimura
authors.forename: Gerard B
authors.initials: GB
authors.lastname: Remijn
authors.forename: Kikuko
authors.initials: K
authors.lastname: Nagao
authors.forename: Toshio
authors.initials: T
authors.lastname: Munesue
authors.forename: Koichi
authors.initials: K
authors.lastname: Iiyama
authors.forename: Tsunehisa
authors.initials: T
authors.lastname: Tsubokawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Haruta
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Inoue
authors.forename: Katsumi
authors.initials: K
authors.lastname: Watanabe
authors.forename: Takanori
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Higashida
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Minabe
mesh_terms: D000328:Adult; D001611:Beta Rhythm / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D003627:Data Interpretation, Statistical; D004558:Electric Stimulation; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008475:Median Nerve / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology*; D010108:Oxyhemoglobins / Q000378:metabolism; D013003:Somatosensory Cortex / Q000098:blood supply / Q000502:physiology*; D019265:Spectroscopy, Near-Infrared
chemical_list: D010108:Oxyhemoglobins