title: [New drug approvals over three decades from 1980 to 2009 in Japan--their therapeutic targets and biochemical properties].
abstract: We analyzed the therapeutic target molecules and biochemical properties of 893 new drugs with new molecular entities approved over three decades from 1980 to 2009 in Japan. According to our analysis of the therapeutic targets, 26.2% of new drugs were enzymes. Membrane receptors were found to be the second-most frequent molecular targets of the new drugs, representing 25.3% of the new drugs approved. The biochemical properties of the drugs were found to have changed over time. Though the total number of new drugs approved from the year 2000 was smaller than that in the 1980s and 1990s, the number of new protein drugs approved in the 2000s, largely recombinant bioactive substances and monoclonal antibodies, increased significantly compared with those approved in the 1980s and 1990s. The results obtained in this study indicated changes in the therapeutic targets, biochemical properties and therapeutic areas of new drugs approved over the last 30 years and suggest the aspects of the future development of new drugs.
authors.affiliation: Department of Pharmacotherapy, Nihon Pharmaceutical University, Kita-adachi-gun, Saitama, Japan. m.muramatsu@nichiyaku.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Muramatsu
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Arisue
mesh_terms: D001669:Biochemical Phenomena; D017277:Drug Approval / Q000706:statistics & numerical data; D015195:Drug Design; D007564:Japan; D058990:Molecular Targeted Therapy / Q000639:trends*; D018160:Receptors, Cytoplasmic and Nuclear; D013997:Time Factors
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear