title: Renal function in children with congenital neurogenic bladder.
abstract: OBJECTIVE
  Preservation of renal function in children with congenital neurogenic bladder is an important goal of treatment for the disease. This study analyzed the evolution of renal function in patients with congenital neurogenic bladder.
  
  
  METHODS
  We reviewed the records of 58 pediatric patients with respect to the following attributes: gender, age, etiology of neurogenic bladder, reason for referral, medical/surgical management, episodes of treated urinary tract infections, urodynamics, DMSA scintigraphy, weight, height, blood pressure, glomerular filtration rate, microalbuminuria and metabolic acidosis. Statistical analysis was performed, adopting the 5% significance level.
  
  
  RESULTS
  The mean age at presentation was 4.2 ± 3.5 years. Myelomeningocele was the most frequent etiology (71.4%). Recurrent urinary tract infection was the reason for referral in 82.8% of the patients. Recurrent urinary tract infections were diagnosed in 84.5% of the patients initially; 83.7% of those patients experienced improvement during follow-up. The initial mean glomerular filtration rate was 146.7 ± 70.1 mL/1.73 m²/min, and the final mean was 193.6 ± 93.6 mL/1.73 m²/min, p = 0.0004. Microalbuminuria was diagnosed in 54.1% of the patients initially and in 69% in the final evaluation. Metabolic acidosis was present in 19% of the patients initially and in 32.8% in the final assessment.
  
  
  CONCLUSIONS
  Patient referral to a pediatric nephrologist was late. A reduction in the number of urinary tract infections was observed with adequate treatment, but microalbuminuria and metabolic acidosis occurred frequently despite adequate management.
authors.affiliation: Instituto da Criança, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. karenpo@terra.com.br
authors.forename: Karen Previdi
authors.initials: KP
authors.lastname: Olandoski
authors.forename: Vera
authors.initials: V
authors.lastname: Koch
authors.forename: Flavio Eduardo
authors.initials: FE
authors.lastname: Trigo-Rocha
mesh_terms: D000138:Acidosis / Q000473:pathology; D000293:Adolescent; D000419:Albuminuria / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004812:Epidemiologic Methods; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D012017:Referral and Consultation / Q000706:statistics & numerical data; D001750:Urinary Bladder, Neurogenic / Q000151:congenital* / Q000209:etiology / Q000503:physiopathology