title: The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.
abstract: Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
authors.forename: Christine C
authors.initials: CC
authors.lastname: Yang
authors.forename: Diana
authors.initials: D
authors.lastname: Chen
authors.forename: Siu Sylvia
authors.initials: SS
authors.lastname: Lee
authors.forename: Ludivine
authors.initials: L
authors.lastname: Walter
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D034281:Dynamins / Q000235:genetics / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D008136:Longevity / Q000502:physiology; D010641:Phenotype; D015398:Signal Transduction
chemical_list: D029742:Caenorhabditis elegans Proteins; D007328:Insulin; D034281:Dynamins; C568498:dynamin-related protein 1, C elegans