title: Services for prediction of drug susceptibility for HIV proteases and reverse transcriptases at the HIV drug research centre.
abstract: CONCLUSIONS
  The HIV Drug Research Centre (HIVDRC) has established Web services for prediction of drug susceptibility for HIV proteases and reverse transcriptases. The services are based on two proteochemometric models which accepts a protease or reverse transcriptase sequence in amino acid form, and outputs the predicted drug susceptibility values. The predictions are based on a comprehensive analysis where all the relevant inhibitors are included, resulting in models with excellent predictive capabilities.
  
  
  METHODS
  The services are implemented as interoperable Web services (REST and XMPP), with supporting web pages to allow for individual analyses. A set of plugins were also developed which make the services available from the Bioclipse workbench for life science. Services are available at http://www.hivdrc.org/services.
authors.affiliation: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. ola.spjuth@farmbio.uu.se
authors.forename: Ola
authors.initials: O
authors.lastname: Spjuth
authors.forename: Martin
authors.initials: M
authors.lastname: Eklund
authors.forename: Maris
authors.initials: M
authors.lastname: Lapins
authors.forename: Muhammad
authors.initials: M
authors.lastname: Junaid
authors.forename: Jarl E S
authors.initials: JE
authors.lastname: Wikberg
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology; D015195:Drug Design; D024882:Drug Resistance, Viral; D006678:HIV / Q000187:drug effects; D016333:HIV Protease / Q000737:chemistry* / Q000235:genetics; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D054303:HIV Reverse Transcriptase / Q000737:chemistry* / Q000235:genetics; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase; D016333:HIV Protease