title: [Effect of low dose propofol on biological behavior of esophageal squamous cell carcinoma cell line Eca109].
abstract: OBJECTIVE
  To detect the effect of low dose propofol on the proliferation, apoptosis, migration, and invasion of esophageal squamous cell carcinoma cell line Eca109.
  
  
  METHODS
  The proliferation, apoptosis, migration, and invasion of esophageal squamous cell carcinoma cell line Eca109 were detected by MTT assay, flow cytometry, transwell assay respectively. The effect of low dose propofol on expression of heme oxygenase-1 (HO-1) was confirmed by Real-time quantitative PCR.
  
  
  RESULTS
  Low dose propofol could inhibit the proliferation, migration, invasion and promate the apoptosis of esophageal squamous cell carcinoma cell line Eca109. And low dose propofol increased the expression of HO-1 mRNA in a dose-dependment manner.
  
  
  CONCLUSIONS
  Low dose propofol affects the biological behavior of esophageal squamous cell carcinoma cell line Eca109, which has a relationship with increasing the expression of HO-1.
authors.affiliation: The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Ling-min
authors.initials: LM
authors.lastname: Zhang
authors.forename: Ming-xin
authors.initials: MX
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Xiao-yi
authors.initials: XY
authors.lastname: Duan
authors.forename: Su-na
authors.initials: SN
authors.lastname: Zhou
authors.forename: Jian-sheng
authors.initials: JS
authors.lastname: Wang
authors.forename: Gui-xia
authors.initials: GX
authors.lastname: Jing
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002294:Carcinoma, Squamous Cell; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004938:Esophageal Neoplasms / Q000473:pathology*; D051547:Heme Oxygenase-1 / Q000235:genetics; D006801:Humans; D009361:Neoplasm Invasiveness; D015742:Propofol / Q000494:pharmacology*
chemical_list: C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1; D015742:Propofol