title: Intraocular sarcoidosis: association of clinical characteristics of uveitis with findings from 18F-labelled fluorodeoxyglucose positron emission tomography.
abstract: OBJECTIVE
  To assess specific clinical criteria in patients with uveitis that are related to signs of sarcoidosis on (18)F-labelled fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET).
  
  
  METHODS
  Retrospective study of 54 consecutive patients with chronic uveitis for whom a PET scan was done because of suspected sarcoidosis, between July 2004 and December 2009. All the patients underwent a clinical examination, biological tests and a high-resolution CT of the chest.
  
  
  RESULTS
  17 of the 54 patients (31.5%) presented hypermetabolic foci on (18)F-FDG-PET scan consistent with sarcoidosis. Among them eight patients (14.8%) underwent biopsy showing non-caseating granuloma. At the end of the study, 10 patients (18.5%) were considered as having a presumed sarcoidosis and seven patients (12.9%) as having indeterminate sarcoidosis. The increasing age at the diagnosis of uveitis (p=0.01), the presence of posterior synechiae (p=0.01) and a positive high-resolution CT of the chest (p=0.01) were significantly related to an abnormal PET scan.
  
  
  CONCLUSIONS
  Increasing age at the diagnosis of uveitis, the presence of posterior synechiae and the positivity of high-resolution chest CT are associated with (18)F-FDG PET scan signs consistent with sarcoidosis.
authors.affiliation: Department of Ophthalmology, Hôpital Croix-Rousse, 103 Grande Rue de la Croix-Rousse, Lyon, France.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Rahmi
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Deshayes
authors.forename: Delphine
authors.initials: D
authors.lastname: Maucort-Boulch
authors.forename: Loig
authors.initials: L
authors.lastname: Varron
authors.forename: Jean Daniel
authors.initials: JD
authors.lastname: Grange
authors.forename: Laurent
authors.initials: L
authors.lastname: Kodjikian
authors.forename: Pascal
authors.initials: P
authors.lastname: Seve
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006099:Granuloma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014605:Uveitis / Q000000981:diagnostic imaging* / Q000473:pathology; D051598:Whole Body Imaging / Q000379:methods; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18