title: Major prospects for exploring canine vector borne diseases and novel intervention methods using 'omic technologies.
abstract: Canine vector-borne diseases (CVBDs) are of major socioeconomic importance worldwide. Although many studies have provided insights into CVBDs, there has been limited exploration of fundamental molecular aspects of most pathogens, their vectors, pathogen-host relationships and disease and drug resistance using advanced, 'omic technologies. The aim of the present article is to take a prospective view of the impact that next-generation, 'omics technologies could have, with an emphasis on describing the principles of transcriptomic/genomic sequencing as well as bioinformatic technologies and their implications in both fundamental and applied areas of CVBD research. Tackling key biological questions employing these technologies will provide a 'systems biology' context and could lead to radically new intervention and management strategies against CVBDs.
authors.affiliation: Department of Veterinary Science, The University of Melbourne, Werribee, Victoria, Australia. robinbg@unimelb.edu.au
authors.forename: Robin B
authors.initials: RB
authors.lastname: Gasser
authors.forename: Cinzia
authors.initials: C
authors.lastname: Cantacessi
authors.forename: Bronwyn E
authors.initials: BE
authors.lastname: Campbell
authors.forename: Andreas
authors.initials: A
authors.lastname: Hofmann
authors.forename: Domenico
authors.initials: D
authors.lastname: Otranto
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary; D035843:Biomedical Research / Q000639:trends; D019295:Computational Biology / Q000379:methods; D004283:Dog Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control*; D004285:Dogs; D020869:Gene Expression Profiling; D016678:Genome; D006374:Helminthiasis, Animal / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D011529:Protozoan Infections, Animal / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D017282:Tick-Borne Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D014730:Veterinary Medicine / Q000639:trends*