title: Podoplanin expression in odontomas: clinicopathological study and immunohistochemical analysis of 86 cases.
abstract: Podoplanin, a sialomucin-like transmembrane glycoprotein, is currently used as a specific marker for lymphatic vessels. However, podoplanin expression has also been linked to tooth development. To investigate the expression of podoplanin in odontomas, 86 tissue samples were classified and then analyzed using immunohistochemical methods. Formalin-fixed, paraffin-embedded specimens were collected and classified, followed by immunohistochemical examination. The majority of the odontomas (66.3%) were the compound type, and the remainder (33.7%) were the complex type. The patients ranged in age from 2 to 89 years (mean, 23.9 years), and 45 (52.3%) of them were male and 41 (47.7%) were female. The most common location for complex odontomas was the molar region of the mandibular bone, and that for compound odontomas was the maxillary incisor region. Immunohistochemistry revealed that developing and mature odontoblasts, Tomes' fibers, and pulp cells near podoplanin-positive odontoblasts were positive for podoplanin. In addition, podoplanin positivity was evident in secretory ameloblasts, but not in mature ameloblasts. The pattern of podoplanin expression in odontomas corresponds to development of the tooth germ, and appears to be influenced by the stage of differentiation of the lesion, suggesting that the protein may participate in the process of differentiation.
authors.affiliation: Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan. patriciagoa@yahoo.com.mx
authors.forename: Patricia
authors.initials: P
authors.lastname: González-Alva
authors.forename: Harumi
authors.initials: H
authors.lastname: Inoue
authors.forename: Yuji
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Hozumi
authors.initials: H
authors.lastname: Tsuchiya
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Noguchi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Fumio
authors.initials: F
authors.lastname: Ide
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Ishihara
authors.forename: Tadashi
authors.initials: T
authors.lastname: Katayama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Sakashita
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kusama
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008875:Middle Aged; D009810:Odontoma / Q000378:metabolism* / Q000473:pathology; D014083:Tooth Germ / Q000254:growth & development; D055815:Young Adult; D000098853:Podoplanin
chemical_list: D008562:Membrane Glycoproteins; C117468:PDPN protein, human; D000098853:Podoplanin