title: Flavans from the leaf of Ilex centrochinensis.
abstract: Phytochemical investigation of the leaf of Ilex centrochinensis led to the isolation and characterization of four flavans, one flavanone (5), and one flavone (6), including a new compound whose structure was elucidated as (2S)-5,3',4'-trihydroxy-7-methoxyflavan (1) and a new natural product whose structure was elucidated as (2S)-5-hydroxy-7,3',4'-trimethoxyflavan (4) on the basis of spectroscopic methods especially 1D and 2D NMR, CD, and mass spectral analyses. Compounds 1 and 4 exhibited weak cytotoxic activity against Huh7 cell line and no cytotoxic activity against Caco-2 cell line.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Lu-Jun
authors.initials: LJ
authors.lastname: Li
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Pi
authors.forename: Han-Li
authors.initials: HL
authors.lastname: Ruan
authors.forename: Ji-Zhou
authors.initials: JZ
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018938:Caco-2 Cells; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D030017:Ilex / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
chemical_list: C558752:(2S)-5,3',4'-trihydroxy-7-methoxyflavan; C558753:(2S)-5-hydroxy-7,3',4'-trimethoxyflavan; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids