title: Altered affinity of the platelet vesicular monoamine transporter 2 to dihydrotetrabenazine in children with major depression.
abstract: Platelet vesicular monoamine transporter (VMAT2) binding characteristics were assessed, using high affinity dihydrotetrabenazine ([(3)H]TBZOH) binding, in 14 children with major depression (MDD) and 16 matched controls. All participants underwent a thorough diagnostic evaluation and the levels of depression and anxiety were measured. K (d) values were significantly lower in children with MDD versus controls (2.93 ± 0.84 vs. 3.63 ± 0.56 nM, respectively, t = 2.4, df = 18.4, p = 0.025). B (max) values did not differ significantly. This preliminary finding indicates a possible structural change in platelet VMAT2 in children with MDD.
authors.affiliation: Geha Mental Health Center, Petach Tikva, Israel. zalsman@post.tau.ac.il
authors.forename: Gil
authors.initials: G
authors.lastname: Zalsman
authors.forename: Moshe
authors.initials: M
authors.lastname: Rehavi
authors.forename: Netta
authors.initials: N
authors.lastname: Roz
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Laor
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.forename: Paz
authors.initials: P
authors.lastname: Toren
mesh_terms: D000293:Adolescent; D001792:Blood Platelets / Q000378:metabolism; D002648:Child; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011485:Protein Binding / Q000502:physiology; D011869:Radioligand Assay; D013747:Tetrabenazine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D014316:Tritium; D050493:Vesicular Monoamine Transport Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: C493452:SLC18A2 protein, human; D050493:Vesicular Monoamine Transport Proteins; D014316:Tritium; C032811:dihydrotetrabenazine; D013747:Tetrabenazine