title: Loading and release of amphotericin-B from biodegradable poly(lactic-co-glycolic acid) nanoparticles.
abstract: Amphotericin B (AmB)-loaded poly(lactic-co-glycolic acid, PLGA) nanoparticles (NP) were prepared by solvent displacement. NP of size 160.7 +/- 10.45 nm, with a polydispersity index of 0.093 +/- 0.012 and a zeta-potential of -15.5 +/- 7.2 mV had satisfactory drug entrapment efficiency (42.5 +/- 6.41%). Biphasic drug release characterized by an initial burst followed by subsequent sustained release was observed. Applicability against visceral leishmaniasis and cancer is under investigation.
authors.affiliation: Pharmaceutics Division, Central Drug Research Institute (CSIR), M. G. Marg, Lucknow 226001, India.
authors.forename: Rahul K
authors.initials: RK
authors.lastname: Verma
authors.forename: Sanket
authors.initials: S
authors.lastname: Pandya
authors.forename: Amit
authors.initials: A
authors.lastname: Misra
mesh_terms: D020341:Absorbable Implants; D000042:Absorption; D000666:Amphotericin B / Q000008:administration & dosage / Q000737:chemistry*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004058:Diffusion; D019344:Lactic Acid / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000935:Antifungal Agents; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D000666:Amphotericin B