title: Mechanism of isoflavone aglycone's effect on cognitive performance of senescence-accelerated mice.
abstract: This study investigated the effect of isoflavone aglycone (IA) on the learning and memory performance of senescence-accelerated mice, and explored its neural protective mechanism. Results showed that SAM-P/8 senescence-accelerated mice treated with IA performed significantly better in the Y-maze cognitive test than the no treatment control (P<0.05). The cortex AchE activity, serum SOD and GSH-Px activities were notably higher (P<0.05). MDA concentration and the β-secretase activity in the hippocampal tissue were both lower (P<0.05). Additionally, the number of hippocampal neurons was increased and cell morphology was significantly improved. Data suggested that IA could indirectly increase concentration of the cholinergic neural transmitter Ach through regulation of AchE, therefore improving the central cholinergic function and enhancing the learning and memory ability. By reducing the β-secretase activity, IA could decrease the formation and deposition of insoluble Adebris, relieve the resulted toxicity and damage to neurons, and thereby effectively protect the nervous system.
authors.affiliation: Jinan University, 601 Huang Pu Road, Guangzhou, Guangdong 510632, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Guifang
authors.initials: G
authors.lastname: Jin
authors.forename: Dongdong
authors.initials: D
authors.lastname: Ren
authors.forename: Sijing
authors.initials: S
authors.lastname: Luo
authors.forename: Tianhong
authors.initials: T
authors.lastname: Zhou
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000375:Aging / Q000187:drug effects / Q000378:metabolism / Q000523:psychology; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003071:Cognition / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D007529:Isoflavones; D010936:Plant Extracts; D013482:Superoxide Dismutase; D000110:Acetylcholinesterase; D053829:Amyloid Precursor Protein Secretases