title: Aminomutases: mechanistic diversity, biotechnological applications and future perspectives.
abstract: Aminomutases carry out the chemically challenging exchange of a hydrogen atom and an amine substituent present on neighboring carbon atoms. In recent years, aminomutases have been intensively investigated for their biophysical, structural and mechanistic characteristics. The reactions catalyzed by these enzymes have considerable potential for biotechnological applications. Here, we present an overview of this diverse group of enzymes, with a focus on enzymatic mechanisms and recent developments in their use in applied biocatalysis.
authors.affiliation: Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
authors.forename: Bian
authors.initials: B
authors.lastname: Wu
authors.forename: Wiktor
authors.initials: W
authors.lastname: Szymański
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Heberling
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
authors.forename: Dick B
authors.initials: DB
authors.lastname: Janssen
mesh_terms: D000588:Amines / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D014644:Genetic Variation; D006859:Hydrogen / Q000378:metabolism; D019751:Intramolecular Transferases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D053858:Metabolic Networks and Pathways; D008958:Models, Molecular
chemical_list: D000588:Amines; D006859:Hydrogen; D019751:Intramolecular Transferases