title: Uridine correlates with the concentration of fructosamine and HbA1c in children with type 1 diabetes.
abstract: OBJECTIVE
  Treating uridine as a product of UTP degradation and hypoxanthine as a degradation product of ATP, we assessed the concentration of uridine and hypoxanthine in the blood of children with newly diagnosed type 1 diabetes. We also sought to define the relationship between indicators of the degree of metabolic control of diabetes (fructosamine, HbA1c) and the concentration of the tested catabolites.
  
  
  METHODS
  This study was carried out on 33 children aged 12.26 ± 4.49 with newly diagnosed type 1 diabetes during their first hospitalization. The concentration of uridine and hypoxanthine was determined by high-performance liquid chromatography (HPLC).
  
  
  RESULTS
  The results showed significantly elevated levels of hypoxanthine and uridine in the blood. We further show that blood uridine level is associated with purine metabolism and hyperglycaemia, and we demonstrate a significant positive correlation between the concentration of uridine and (i) the percentage of HbA1c and (ii) fructosamine levels, which indicate the role of hyperglycaemia in the pathogenesis of pyrimidine nucleotide metabolism in type 1 diabetes prior to diagnosis.
  
  
  CONCLUSIONS
  The results confirm the existence of a relationship between the degree of metabolic control of diabetes and pyrimidine metabolism. Presumably, the analysis of uridine could be used as an adjunct marker of the severity of diabetic complications in newly diagnosed patients.
authors.affiliation: Department of Physiology, Faculty of Natural Sciences of Szczecin University, Poland. wiola@univ.szczecin.pl
authors.forename: W
authors.initials: W
authors.lastname: Dudzinska
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D019270:Fructosamine / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D019271:Hypoxanthine / Q000097:blood*; D012720:Severity of Illness Index; D014529:Uridine / Q000097:blood*
chemical_list: D015415:Biomarkers; D019270:Fructosamine; D006442:Glycated Hemoglobin; D019271:Hypoxanthine; D014529:Uridine; C517652:hemoglobin A1c protein, human