title: [L-carnitine treatment and fish odor syndrome: an unwaited adverse effect].
abstract: BACKGROUND
  Levocarnitine treatment is usually well tolerated, with essentially dose-dependent diarrhea as the main induced adverse effect.
  
  
  METHODS
  We report a case of fish odor syndrome during levocarnitine treatment which resolved after levocarnitine discontinuation.
  
  
  CONCLUSIONS
  This adverse effect seems to be correlated with excedent carnitine intake and might be expressed when the elimination pathway becomes saturated or in a situation of deficiency enzymatic metabolism.
authors.affiliation: Centre Régional de Pharmacovigilance de Nice, CHU de Nice, Hôpital Cimiez, 4 avenue Victoria, BP 1179, 06003 Nice cedex 1, France. Rocher.f@chu-nice.fr
authors.forename: F
authors.initials: F
authors.lastname: Rocher
authors.forename: C
authors.initials: C
authors.lastname: Caruba
authors.forename: F
authors.initials: F
authors.lastname: Broly
authors.forename: C
authors.initials: C
authors.lastname: Lebrun
mesh_terms: D002331:Carnitine / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008661:Metabolism, Inborn Errors / Q000139:chemically induced / Q000652:urine; D008744:Methylamines / Q000652:urine; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy; D009812:Odorants; D012521:Sarcosine / Q000031:analogs & derivatives / Q000652:urine
chemical_list: D008744:Methylamines; C025138:dimethylglycine; C005855:trimethyloxamine; C023336:trimethylamine; D002331:Carnitine; D012521:Sarcosine