title: Reevaluating the role of LTD in cerebellar motor learning.
abstract: Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or αCamKII) necessary for induction of PF-PC LTD and thereby determine if cerebellar motor learning is impaired. Here, we tested three mutant mice that target the expression of PF-PC LTD by blocking internalization of AMPA receptors. Using three different cerebellar coordination tasks (adaptation of the vestibulo-ocular reflex, eyeblink conditioning, and locomotion learning on the Erasmus Ladder), we show that there is no motor learning impairment in these mutant mice that lack PF-PC LTD. These findings demonstrate that PF-PC LTD is not essential for cerebellar motor learning.
authors.affiliation: Department of Neuroscience, Dr Molewaterplein 50, Erasmus MC, 3015 GE Rotterdam, The Netherlands.
authors.forename: Martijn
authors.initials: M
authors.lastname: Schonewille
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Gao
authors.forename: Henk-Jan
authors.initials: HJ
authors.lastname: Boele
authors.forename: Maria F Vinueza
authors.initials: MF
authors.lastname: Veloz
authors.forename: Wardell E
authors.initials: WE
authors.lastname: Amerika
authors.forename: Antonia A M
authors.initials: AA
authors.lastname: Simek
authors.forename: Marcel T
authors.initials: MT
authors.lastname: De Jeu
authors.forename: Jordan P
authors.initials: JP
authors.lastname: Steinberg
authors.forename: Kogo
authors.initials: K
authors.lastname: Takamiya
authors.forename: Freek E
authors.initials: FE
authors.lastname: Hoebeek
authors.forename: David J
authors.initials: DJ
authors.lastname: Linden
authors.forename: Richard L
authors.initials: RL
authors.lastname: Huganir
authors.forename: Chris I
authors.initials: CI
authors.lastname: De Zeeuw
mesh_terms: D000818:Animals; D001767:Blinking / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology*; D055879:Gene Knock-In Techniques; D007858:Learning / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*