title: Expression and nutritional regulation of the (pro)renin receptor in rat visceral adipose tissue.
abstract: BACKGROUND
  Early life nutritional environment plays an important role in the development of visceral adipose tissue and interacts with nutritional regulations in adulthood, leading to metabolic dysregulations.
  
  
  OBJECTIVE
  We hypothesized that the renin-angiotensin system may play a role in the programming-induced development of visceral adipose tissue.
  
  
  METHODS
  We studied, using a model of programming of overweight and glucose intolerance, obtained by post-natal overfeeding with consecutive highfat diet, the status of plasma renin activity and mesenteric adipose renin-angiotensin system, including the recently identified (pro)renin receptor, in adult rats.
  
  
  RESULTS
  Post-natal overfeeding or high-fat feeding lead to overweight with increased visceral fat mass and adipocytes surface. When both paradigms were associated, adipocytes surface showed a disproportionate increase. A strong immunoreactivity for (pro)renin receptor was found in stromal cells. Plasma renin activity increased in programmed animals whereas (pro)renin receptor expressing cells density was stimulated by high-fat diet. There was a positive, linear relationship between plasma renin activity and (pro)renin receptor expressing cells density and adipocytes surface.
  
  
  CONCLUSIONS
  Our experiments demonstrate that association of post-natal overfeeding and high-fat diet increased plasma renin activity and adipose (pro)renin receptor expression. Such phenomenon could explain, at least in part, the associated disproportionate adipocyte hypertrophy and its accompanying increased glucose intolerance.
authors.affiliation: Aix-Marseille University, Laboratoire d'Histologie-Embryologie, Marseille, France.
authors.forename: V
authors.initials: V
authors.lastname: Achard
authors.forename: V
authors.initials: V
authors.lastname: Tassistro
authors.forename: S
authors.initials: S
authors.lastname: Boullu-Ciocca
authors.forename: M
authors.initials: M
authors.lastname: Grino
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002452:Cell Count; D059305:Diet, High-Fat / Q000379:methods; D005260:Female; D005786:Gene Expression Regulation; D050152:Intra-Abdominal Fat / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009752:Nutritional Status / Q000502:physiology*; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000378:metabolism; D012083:Renin / Q000096:biosynthesis*; D000093342:Prorenin Receptor
chemical_list: D011956:Receptors, Cell Surface; D012083:Renin; D000093342:Prorenin Receptor