title: Asymmetric synthesis of α-amino acids by reduction of N-tert-butanesulfinyl ketimine esters.
abstract: A highly regio- and diastereoselective reduction of various N-tert-butanesulfinyl ketimine esters with L-Selectride resulting in the formation of α-amino acids is reported. This method is quite general and also practical for the preparation of both enantiomers of aryl or aliphatic α-amino acids in high yields.
authors.affiliation: Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. rajender.leleti@novartis.com
authors.forename: Leleti Rajender
authors.initials: LR
authors.lastname: Reddy
authors.forename: Aditya P
authors.initials: AP
authors.lastname: Gupta
authors.forename: Yugang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D004952:Esters; D007097:Imines / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000596:Amino Acids; D004952:Esters; D007097:Imines; D009570:Nitriles; C542835:ketimine