title: [Remaxol restores the liver antioxidant protection system in experimental cyclophosphan-induced injury].
abstract: It is established that remaxol influences the main links of cells antioxidant system in case of experimental drug-induced liver damage. The injection of remaxol to animals with hepatotoxic damage increases the level of restored glutathione and maintains the concentration of SH groups of proteins in liver tissues on the level typical of intact animals. Remaxol helps to keep intact the energetic substrates of hepatocytes by saving the activity of glucose-6-phosphatedehydrogenase (which increases restored NADPH and glutathione enzymes), thus preventing the oxidative destruction of glutathione reductase and glutathione S-transferase. The antioxidant effect has been also confirmed by the study of catalase and glutathione peroxidase activity, the concentration of which under the action of remaxol increased above the normal level. Additional evidence is a remaxol-induced decrease in concentration of the final products of lipid peroxidation.
authors.forename: A L
authors.initials: AL
authors.lastname: Kovalenko
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Petrov
authors.forename: D S
authors.initials: DS
authors.lastname: Sukhanov
authors.forename: T N
authors.initials: TN
authors.lastname: Savateeva
authors.forename: M G
authors.initials: MG
authors.lastname: Romantsov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D019069:Cell Respiration / Q000187:drug effects; D003520:Cyclophosphamide / Q000633:toxicity*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D013386:Succinates / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; C555877:Remaxol; D013386:Succinates; D003520:Cyclophosphamide; D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase