title: Changes in resting connectivity during recovery from severe traumatic brain injury.
abstract: In the present study we investigate neural network changes after moderate and severe traumatic brain injury (TBI) through the use of resting state functional connectivity (RSFC) methods. Using blood oxygen level dependent functional MRI, we examined RSFC at 3 and 6 months following resolution of posttraumatic amnesia. The goal of this study was to examine how regional off-task connectivity changes during a critical period of recovery from significant neurological disruption. This was achieved by examining regional changes in the intrinsic, or "resting", BOLD fMRI signal in separate networks: 1) regions linked to goal-directed (or external-state) networks and 2) default mode (or internal-state) networks. Findings here demonstrate significantly increased resting connectivity internal-state networks in the TBI sample during the first 6 months following recovery. The most consistent finding was increased connectivity in both internal and external state networks to the insula and medial temporal regions during recovery. These findings were dissociable from repeat measurements in a matched healthy control sample.
authors.affiliation: Department of Psychology, Penn State University, University Park, PA 16802, USA. fhillary@psu.edu
authors.forename: F G
authors.initials: FG
authors.lastname: Hillary
authors.forename: J
authors.initials: J
authors.lastname: Slocomb
authors.forename: E C
authors.initials: EC
authors.lastname: Hills
authors.forename: N M
authors.initials: NM
authors.lastname: Fitzpatrick
authors.forename: J D
authors.initials: JD
authors.lastname: Medaglia
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: D C
authors.initials: DC
authors.lastname: Good
authors.forename: G R
authors.initials: GR
authors.lastname: Wylie
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D020127:Recovery of Function / Q000502:physiology*; D012146:Rest; D013997:Time Factors; D055815:Young Adult
chemical_list: D010100:Oxygen