title: Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial.
abstract: On five commercial cattle rearing sites across Europe, a total of 802 young cattle at high risk of developing bovine respiratory disease (BRD) associated with the bacterial pathogens Mannheimia haemolytica or Pasteurella multocida and/or Mycoplasma bovis were enrolled into a multicentre, controlled field trial. Half were treated with a single dose of gamithromycin at 6 mg/kg bodyweight by subcutaneous injection and half received an injection of a saline placebo as the control. All animals were observed daily for 14 days for signs of BRD as defined by set criteria. The proportion of metaphylactic preventive treatment successes, defined as animals surviving to day 14 without signs of BRD, in the gamithromycin-treated group (86 per cent) was significantly (P=0.0012) higher than in the saline-treated controls (61 per cent). Morbidity among the treated animals was reduced by 64 per cent compared with the controls.
authors.affiliation: Merial, Centre de Recherche de Saint Vulbas, Parc Industriel de la Plaine de l'Aine, Allee des Cypres, 01150 Saint Vulbas, France. derek.baggott@merial.com
authors.forename: D
authors.initials: D
authors.lastname: Baggott
authors.forename: A
authors.initials: A
authors.lastname: Casartelli
authors.forename: F
authors.initials: F
authors.lastname: Fraisse
authors.forename: C
authors.initials: C
authors.lastname: Manavella
authors.forename: R
authors.initials: R
authors.lastname: Marteau
authors.forename: S
authors.initials: S
authors.lastname: Rehbein
authors.forename: M
authors.initials: M
authors.lastname: Wiedemann
authors.forename: S
authors.initials: S
authors.lastname: Yoon
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D048090:Bovine Respiratory Disease Complex / Q000188:drug therapy* / Q000382:microbiology*; D002417:Cattle; D005260:Female; D018942:Macrolides / Q000627:therapeutic use*; D008297:Male; D016978:Mannheimia haemolytica / Q000187:drug effects; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D045682:Mycoplasma bovis / Q000187:drug effects; D010326:Pasteurella Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D016979:Pasteurella multocida / Q000187:drug effects; D048089:Pneumonia of Calves, Enzootic / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C552399:gamithromycin