title: Supramolecular architectures self-assembled from asymmetrical hetero cyclopeptides.
abstract: In this study, two asymmetrical cyclopeptides (CP1 and CP2) were designed and synthesized. The self-assembly behaviors of the asymmetrical cyclopeptides at varying pHs were investigated in terms of transmission electron microscopy (TEM), circular dichroism (CD), and Fourier transform infrared (FT-IR) spectroscopy. It was found that the self-assembly of CP1 resulted in the formation of nanofibers with α-helix conformation, while CP2 self-assembled into well-ordered nanorods with anti-parallel β-sheet conformation. The strategy demonstrated here presents great potential for preparation of well-defined nanostructures via rationally designing the molecular structures of cyclopeptides.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, China.
authors.forename: Si-Yong
authors.initials: SY
authors.lastname: Qin
authors.forename: Xiao-Ding
authors.initials: XD
authors.lastname: Xu
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Chen
authors.forename: Jing-Xiao
authors.initials: JX
authors.lastname: Chen
authors.forename: Ze-Yong
authors.initials: ZY
authors.lastname: Li
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D002942:Circular Dichroism; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D010456:Peptides, Cyclic