title: Dragon's Blood extract has antithrombotic properties, affecting platelet aggregation functions and anticoagulation activities.
abstract: BACKGROUND
  Dragon's Blood from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China), as a traditional Chinese medicinal herb, was shown to have certain antithrombotic effects. A new preparation process was used to extract effective components from Dragon's Blood. A 95% ethanol extract A (EA) and a precipitate B (PB) fraction were obtained and compared. Reliability of the preparation process was validated by pharmacodynamic experiments.
  
  
  METHODS
  A rat/mouse thrombosis and blood stasis model was developed for this study, and EA and PB effects on thrombosis, platelet functions and blood coagulation activities were analyzed.
  
  
  RESULTS
  It was observed that the EA fraction had significantly better inhibitory effects than the PB fraction on thrombosis (p<0.05), platelet aggregation function (p<0.01) and anticoagulation activity (p<0.05-0.01).
  
  
  CONCLUSIONS
  The results obtained here showed that EA fraction from Dragon's Blood contained pharmacologically effective compounds with antithrombotic effects, partially improving platelet function and anticoagulation activity.
authors.affiliation: School of Life Science, Beijing Institute of Technology (BIT), 5 South Zhongguancun Street, Haidian District, Beijing 100081, PR China.
authors.forename: Nian
authors.initials: N
authors.lastname: Xin
authors.forename: Yu-Juan
authors.initials: YJ
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Rong-Ji
authors.initials: RJ
authors.lastname: Dai
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Meng
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Michael
authors.initials: M
authors.lastname: Schlappi
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Deng
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D000991:Antithrombins / Q000494:pharmacology*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C525191:dragon's blood