title: Microbial transformation of deoxyandrographolide by Fusarium graminearum AS 3.4598.
abstract: Biotransformation of deoxyandrographolide (1) by Fusarium graminearum AS 3.4598 was investigated in this paper. And five transformed products of 1 by F. graminearum AS 3.4598 were obtained. Their chemical structures were characterized as 3-oxo-8α,17β-epoxy-14-deoxyandrographolide (2), 3-oxo-14-deoxyandrographolide (3), 3-oxo-17,19-dihydroxyl-8,13-ent-labdadien-15,16-olide (4), 1β-hydroxyl-14-deoxyandrographolide (5), and 7β-hydroxyl-14-deoxyandrographolide (6) by spectral methods including 2D NMR. Among them, products 2, 4, and 5 are new.
authors.affiliation: Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing, China.
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Xin
authors.forename: Xun
authors.initials: X
authors.lastname: Cui
authors.forename: Changyuan
authors.initials: C
authors.lastname: Wang
authors.forename: Bao-Jing
authors.initials: BJ
authors.lastname: Zhang
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Ma
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Huang
authors.forename: Sha
authors.initials: S
authors.lastname: Deng
authors.forename: Yan
authors.initials: Y
authors.lastname: Tian
authors.forename: Hou-Li
authors.initials: HL
authors.lastname: Zhang
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Yang
mesh_terms: D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D005670:Fusarium / Q000378:metabolism*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: C114791:14-deoxyandrographolide; D004224:Diterpenes