title: Food as a bariatric drug.
abstract: As obesity, type 2 diabetes (T2DM) and the metabolic syndrome sweep across the research and the clinical landscape of medical care, effective pharmacologic remedies for the treatment of obesity have become imperative. The complexities of nutrient impact on neurotransmitter and endocrine modulating chemistry have become increasingly better characterized as have the basic neurochemical pathways that mediate their effects. Food addiction has emerged as an important phenomenon that may help to explain and improve our capabilities of rendering bench lab research into impactful clinical intervention. Against this challenging backdrop of current research and study we introduce the notion that food may in fact, itself, represent a type of drug. In this review chapter of food as a drug, we outline some of the emerging science that argues how proteins, carbohydrates and fats operating on three basic levels of organismic functioning may constitute the most powerful drugs we have available to effectuate weight loss or weight gain over time. In addition, certain foods may not only be more addictive than others, but may actually have a direct effect on pro-inflammatory mediators that determine both metabolic dysfunction as well as overall neuropsychiatric function and well-being.
authors.affiliation: Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL 32610-0183, USA. shriner@ufl.edu
authors.forename: Richard L
authors.initials: RL
authors.lastname: Shriner
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D005502:Food / Q000706:statistics & numerical data*; D006801:Humans; D009765:Obesity / Q000517:prevention & control*; D015431:Weight Loss