title: Melatonin receptor 1A gene polymorphism associated with polycystic ovary syndrome.
abstract: OBJECTIVE
  Melatonin receptor 1A (MTNR1A) gene is a regulator of circadian rhythms and reproductive processes. The MTNR1A gene is also a potential candidate gene of polycystic ovary syndrome (PCOS). The aim of the present study was to determine whether or not the MTNR1A gene polymorphism is associated with a predisposition to PCOS.
  
  
  METHODS
  The single nucleotide polymorphism (SNP) rs2119882 in the MTNR1A gene was detected in 482 patients with PCOS and 522 healthy Chinese Han women. Subsequently, the association of MTNR1A gene variants with plasma glucose, insulin levels during oral glucose tolerance tests (OGTTs) and hormone levels was investigated.
  
  
  RESULTS
  The frequencies of genotypes and allelotypes of SNP rs2119882 differed significantly between PCOS cases and healthy controls (p < 0.001 and p = 0.002, respectively). SNP rs2119882 was associated with higher fasting plasma glucose concentrations (p = 0.021) and OGTT-induced insulin release at 0, 30, 60, and 120 min (all p < 0.05) in PCOS cases, as well as an increased homeostasis model assessment for insulin resistance (p = 0.005).
  
  
  CONCLUSIONS
  SNP rs2119882 is associated with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Affiliated Hospital of Medical College of Qingdao University, Qingdao, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Shi
authors.forename: Li
authors.initials: L
authors.lastname: You
authors.forename: Laicheng
authors.initials: L
authors.lastname: Wang
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001786:Blood Glucose; D016022:Case-Control Studies; D002681:China; D017931:DNA Primers; D005260:Female; D020022:Genetic Predisposition to Disease; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D044122:Receptor, Melatonin, MT1 / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D017931:DNA Primers; D007328:Insulin; D044122:Receptor, Melatonin, MT1