title: Administration of clozapine to a mother rat potentiates pup ultrasonic vocalization in response to separation and re-separation: contrast with haloperidol.
abstract: The present study examined how haloperidol (typical) and clozapine (atypical) treatment to mother rats affected their pups' ultrasonic vocalization (USV) response to maternal separation and re-separation (termed "maternal potentiation"). Clozapine (10 mg/kg, sc) but not haloperidol (0.2 mg/kg, sc) significantly enhanced the maternal potentiation of 40 kHz USVs in pups that were briefly reunited with their dams. This novel paradigm provides an indirect way of assessing the impact of antipsychotic treatment on the quality of maternal care. It may also be useful in examining the impact of antipsychotic treatment on social bonding between infants and mothers.
authors.affiliation: Department of Psychology, University of Nebraska-Lincoln, Lincoln, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Katherine
authors.initials: K
authors.lastname: Heupel
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003024:Clozapine / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008425:Maternal Behavior / Q000187:drug effects; D008426:Maternal Deprivation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014828:Vocalization, Animal / Q000187:drug effects*
chemical_list: D003024:Clozapine; D006220:Haloperidol