title: SUMOylation and de-SUMOylation in response to DNA damage.
abstract: To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).
authors.affiliation: Department of Cardiology, The University of Texas, M.D. Anderson Cancer Center, TX 77030, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Dou
authors.forename: Chao
authors.initials: C
authors.lastname: Huang
authors.forename: Thang
authors.initials: T
authors.lastname: Van Nguyen
authors.forename: Long-Sheng
authors.initials: LS
authors.lastname: Lu
authors.forename: Edward T H
authors.initials: ET
authors.lastname: Yeh
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008957:Models, Genetic; D051135:Rad51 Recombinase / Q000378:metabolism; D011995:Recombination, Genetic; D051716:Replication Protein A / Q000378:metabolism; D058207:Sumoylation
chemical_list: C497167:RPA1 protein, human; D051716:Replication Protein A; D004247:DNA; C495153:RAD51 protein, human; D051135:Rad51 Recombinase