title: Detection of A B acute lymphoblastic leukaemia blast-specific mutation in HLA-B*39:01.
abstract: Human leucocyte antigen (HLA) modifications observed in blast cells in haematologic malignancies can play an important role in disease progression and its therapy. Here we describe an insertion/deletion mutation in the second exon of HLA-B*39:01 that occurred in the blast cells of a patient with B-ALL. This mutation was not present in the nonleukemic cells, in which HLA-B*39:01 was normally expressed.
authors.affiliation: Czech National Marrow Donors Registry, HLA Laboratory, Pilsen, Czech Republic Department of Haematology and Oncology, University Hospital Pilsen, Czech Republic. venigova@kostnidren.cz
authors.forename: P
authors.initials: P
authors.lastname: Venigová
authors.forename: P
authors.initials: P
authors.lastname: Jindra
authors.forename: V
authors.initials: V
authors.lastname: Koza
mesh_terms: D001773:Blood Cells / Q000473:pathology; D005091:Exons; D005260:Female; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology
chemical_list: D015235:HLA-B Antigens