title: [Infectious bone diseases].
abstract: Bacterial infection of the bone is a severe disease with complications, potentially including long-term physical disability. The diagnosis and therapy of osteomyelitis include several elements: histopathology, microbiology, radiologic imagining, as well as antibiotic and surgical therapy. Histopathologists differentiate between acute osteomyelitis (infiltration of cancellous bone with neutrophil granulocytes); specific osteomyelitis (epithelioid-like granulomatous inflammation, tuberculosis, mycotic infections); primary/secondary chronic osteomyelitis (lymphocytic infiltration); and special forms of chronic osteomyelitis (varying histomorphology, Brodie abscess, SAPHO syndrome). Another important task in the histopathological diagnosis of inflammatory bone diseases is to differentiate osteomyelitis from malignant entities (sarcoma, lymphoma). Therefore, biopsy samples should be of sufficient size for safe diagnosis. Clinical information and imaging as well as interdisciplinary teamwork between radiologists, microbiologists, orthopedic surgeons and pathologists is mandatory to verify these diagnoses.
authors.affiliation: Abteilung für Septische und Rekonstruktive Chirurgie der Klinik für Unfall- und Wiederherstellungschirurgie, BG-Kliniken Bergmannstrost Halle, Merseburger Str. 165, 06112, Halle. andreas.tiemann@bergmannstrost.com
authors.forename: A H
authors.initials: AH
authors.lastname: Tiemann
authors.forename: V
authors.initials: V
authors.lastname: Krenn
authors.forename: M G
authors.initials: MG
authors.lastname: Krukemeyer
authors.forename: C
authors.initials: C
authors.lastname: Seyfert
authors.forename: M
authors.initials: M
authors.lastname: Jakobs
authors.forename: D
authors.initials: D
authors.lastname: Baumhoer
authors.forename: G O
authors.initials: GO
authors.lastname: Hofmann
mesh_terms: D000038:Abscess / Q000209:etiology / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000209:etiology / Q000473:pathology*; D001706:Biopsy; D001850:Bone Diseases, Infectious / Q000209:etiology / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010000:Osteitis / Q000209:etiology / Q000473:pathology; D010019:Osteomyelitis / Q000209:etiology / Q000473:pathology; D012307:Risk Factors