title: [Pathways of arsenic uptake in prokaryotic and eukaryotic cells].
abstract: Mechanisms of arsenic uptake and detoxification are present in all studied organisms. These mechanisms are considerably well described in unicellular organisms such as bacterium Escherichia coli and baker's yeast Saccharomyces cerevisiae, still leaving much to be revealed in multicellular organisms. Full identification of arsenic uptake and detoxification is of great importance. This knowledge can be very helpful in improving effectiveness of arsenic-containing drugs used in chemotherapy of parasitoses as well as in treatment of acute promielyocytic leukemia. Increased proficiency of bioremediation of arsenic-contaminated soils can be obtained by using plants hyperaccumulating arsenic. This kind of plants can be engineered by modulating expression levels of genes encoding arsenic transporters. The same technique may be used to decrease levels of accumulated arsenic in crops. The aim of this paper is to review current knowledge about systems of arsenic uptake in every studied organism--from bacteria to human.
authors.affiliation: Zakład Genetyki, Instytut Genetyki i Mikrobiologii, Wydział Nauk Biologicznych, Uniwersytet Wrocławski, Wrocław.
authors.forename: Paweł
authors.initials: P
authors.lastname: Lis
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Litwin
authors.forename: Ewa
authors.initials: E
authors.lastname: Maciaszczyk-Dziubińska
mesh_terms: D000818:Animals; D020346:Aquaporins / Q000378:metabolism; D001151:Arsenic / Q000493:pharmacokinetics*; D001692:Biological Transport; D052918:Environmental Restoration and Remediation; D004926:Escherichia coli / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy; D010272:Parasitic Diseases / Q000188:drug therapy; D010944:Plants / Q000378:metabolism; D011387:Prokaryotic Cells / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D012989:Soil Pollutants / Q000378:metabolism
chemical_list: D020346:Aquaporins; D012989:Soil Pollutants; D001151:Arsenic