title: Protective effects of ginger toward cadmium-induced testes and kidney lipid peroxidation and hematological impairment in albino rats.
abstract: This study was carried out to investigate the effect of oral dietary supplementation with ginger on cadmium-induced toxic effects on biochemical, hematological, and pathophysiological indices of albino rats. The effect of cadmium and cadmium/ginger treatment on lipid peroxidation was measured by malondialdehyde (MDA) levels in testes and kidney; serum activities of alkaline phosphatase (ALP), acid phosphatase (ACP), and prostatic acid phosphatase (PAP) enzyme were investigated alongside hematological indices. The results showed that cadmium induces a significant increase in both testicular and kidney MDA, whereas cadmium/ginger treatment produced a significant reversal of the effect of lipid peroxidation (P=.004). Cadmium treatment induced 75%, 78%, and 22% increases in activities of ACP, PAP, and ALP, respectively, whereas the cadmium/ginger-treated group reversed these values for enzyme activities (P=.001). Results of organ weight and hematological indices analysis in the cadmium-treated rats showed a decrease in organ weight and distortion of the hemopoietic features, whereas the cadmium/ginger-treated rats showed an improvement in organ weight and hematological indices (P=.04 and .001, respectively). The reversal of the toxic effects of cadmium in the cadmium/ginger-treated albino rats heralds the antioxidant potency of ginger toward cadmium toxicity-associated oxidative stress.
authors.affiliation: Department of Biochemistry, College of Health Sciences, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria.
authors.forename: Frank C
authors.initials: FC
authors.lastname: Onwuka
authors.forename: Osaro
authors.initials: O
authors.lastname: Erhabor
authors.forename: M U
authors.initials: MU
authors.lastname: Eteng
authors.forename: I B
authors.initials: IB
authors.lastname: Umoh
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002104:Cadmium / Q000633:toxicity*; D020939:Zingiber officinale / Q000737:chemistry*; D006401:Hematologic Agents / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D023421:Models, Animal; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D006401:Hematologic Agents; D010936:Plant Extracts; D020011:Protective Agents; D002104:Cadmium; D008315:Malondialdehyde