title: Added value of an oropharyngeal swab in detection of viruses in children hospitalized with lower respiratory tract infection.
abstract: Paired nasopharyngeal and oropharyngeal swabs collected from 533 children hospitalized with lower respiratory tract infection were assessed by multiplex reverse transcription-PCR. Oropharyngeal swabs increased the number of viral infections detected by 15%, compared to collection of a nasopharyngeal swab alone. This advantage was most pronounced for detection of influenza, parainfluenza, and adenovirus.
authors.affiliation: KEMRI Wellcome Trust Research Programme, Kilifi, Kenya. llhammitt@gmail.com
authors.forename: Laura L
authors.initials: LL
authors.lastname: Hammitt
authors.forename: Sidi
authors.initials: S
authors.lastname: Kazungu
authors.forename: Steve
authors.initials: S
authors.lastname: Welch
authors.forename: Anne
authors.initials: A
authors.lastname: Bett
authors.forename: Clayton O
authors.initials: CO
authors.lastname: Onyango
authors.forename: Rory N
authors.initials: RN
authors.lastname: Gunson
authors.forename: J Anthony G
authors.initials: JA
authors.lastname: Scott
authors.forename: D James
authors.initials: DJ
authors.lastname: Nokes
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009305:Nasopharynx / Q000821:virology; D009960:Oropharynx / Q000821:virology*; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000821:virology*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods*; D014773:Virology / Q000379:methods; D014777:Virus Diseases / Q000175:diagnosis* / Q000821:virology*; D014780:Viruses / Q000302:isolation & purification*