title: [Research progression of PPARgamma to bone remodeling].
abstract: Peroxisome proliferator activated receptor gamma interacts with bone morphogenetic protein, Wnt, TAZ, and insulin-like growth factor-I, which are required for the process of osteoblast differentiation, regulating the mesenchymal stem cells (MSCs) into adipocytes and osteoblasts differentiation, thus impact on the osteoblast-mediated bone formation in bone remodeling, and, through RANKL and other factors directly or indirectly, regulate osteoclast-mediated bone resorption. This article reviews new researches for the influence of peroxisome proliferator activated receptor gamma on osteoblast and osteoclast function in bone remodeling.
authors.affiliation: Department of Endocrinology, The Third Hospital, Hebei Medical University, Shijiazhuang 050051, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Baoxin
authors.initials: B
authors.lastname: Li
authors.forename: Yukun
authors.initials: Y
authors.lastname: Li
mesh_terms: D016723:Bone Remodeling / Q000502:physiology*; D006801:Humans; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D047495:PPAR gamma / Q000502:physiology*
chemical_list: D047495:PPAR gamma