title: Maxillary sinus augmentation with microstructured tricalcium phosphate ceramic in sheep.
abstract: OBJECTIVE
  The objective of this study was to evaluate the biological performance of osteoinductive microstructured tricalcium phosphate (MSTCP) particles in maxillary sinus floor augmentation surgery in sheep.
  
  
  METHODS
  Sinus floor augmentation was performed in eight Swifter sheep. In each animal, the maxillary sinus floor was unilaterally augmented with MSTCP particles. Computed tomography (CT) imaging and histological analyses were performed after 12 weeks of implantation.
  
  
  RESULTS
  Maxillofacial CT, histology, histomorphometrical analysis and sequential polychrome fluorescent labeling indicated that MSTCP particles provided a scaffold for cell ingrowth and bone formation. After a 12-week implantation period, the sinuses grafted with MSTCP showed an increased bone height of 6 mm and a mean total bone volume of 43%, with significant degradation of MSTCP particles.
  
  
  CONCLUSIONS
  MSTCP particles represent a suitable bone substitute material for maxillary sinus floor augmentation surgery.
authors.affiliation: Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Klijn
authors.forename: J W M
authors.initials: JW
authors.lastname: Hoekstra
authors.forename: J J J P
authors.initials: JJ
authors.lastname: Van Den Beucken
authors.forename: G J
authors.initials: GJ
authors.lastname: Meijer
authors.forename: J A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D018786:Bone Substitutes / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000494:pharmacology*; D005260:Female; D008437:Maxilla / Q000000981:diagnostic imaging / Q000601:surgery; D010012:Osteogenesis; D034561:Sheep, Domestic; D059546:Sinus Floor Augmentation / Q000379:methods*; D013194:Staining and Labeling; D018709:Statistics, Nonparametric; D054457:Tissue Scaffolds; D014057:Tomography, X-Ray Computed
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C018392:tricalcium phosphate