title: Different risk factor profiles between silent brain infarction and symptomatic lacunar infarction.
abstract: OBJECTIVE
  It is generally assumed that silent brain infarction (SBI) and symptomatic lacunar infarction (sLAC) share common vascular risk factors and their pathogeneses are known to be similar. However, few studies have conducted a risk factor profile analysis of the two diseases in a single study design.
  
  
  METHODS
  This study included 64 subjects with SBI lesions, 140 patients with sLAC, and 342 controls by retrospective investigation of brain MRI. Topographic findings and vascular risk factor profiles were compared.
  
  
  CONCLUSIONS
  Compared to the controls, the SBI group was found to be associated with hypertension (p = 0.002) and elevated plasma total homocysteine level (p = 0.02). The sLAC group was found to be associated with hypertension (p = 0.001), diabetes (p = 0.004), smoking (p = 0.002), ischemic heart disease (p = 0.01) and hyperlipidemia (p = 0.04). In the present study, risk factor profiles of the SBI and sLAC were not exactly the same, indicating a different pathogenesis between the two diseases.
authors.affiliation: Department of Neurology, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.
authors.forename: Mi-Hwa
authors.initials: MH
authors.lastname: Kim
authors.forename: Ju-Sun
authors.initials: JS
authors.lastname: Moon
authors.forename: So-Young
authors.initials: SY
authors.lastname: Park
authors.forename: Se-A
authors.initials: SA
authors.lastname: An
authors.forename: Ok-Joon
authors.initials: OJ
authors.lastname: Kim
authors.forename: Nam-Keun
authors.initials: NK
authors.lastname: Kim
authors.forename: Seung-Hun
authors.initials: SH
authors.lastname: Oh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D020520:Brain Infarction / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors