title: A mathematical model of human thymidine kinase 2 activity.
abstract: The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.
authors.affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA. txr24@case.edu
authors.forename: T
authors.initials: T
authors.lastname: Radivoyevitch
authors.forename: B
authors.initials: B
authors.lastname: Munch-Petersen
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Eriksson
mesh_terms: D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D013937:Thymidine Kinase / Q000378:metabolism*
chemical_list: C105339:thymidine kinase 2; D013937:Thymidine Kinase