title: Oral antibiotics for infections due to multidrug-resistant Gram-negative organisms.
abstract: We determined minimum inhibitory concentrations of rifampicin, nitrofurantoin, amoxicillin-clavulanic acid, and cefdinir, plus a combination of amoxicillin-clavulanic acid and cefdinir by broth microdilution for mainly wound isolates of Escherichia coli and Klebsiella pneumoniae. E. coli and K. pneumoniae susceptibilities increased by combining amoxicillin-clavulanic acid and cefdinir.
authors.affiliation: Infectious Disease Service, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, Texas 78234, USA. Clinton.Murray@amedd.army.mil
authors.forename: Jessie S
authors.initials: JS
authors.lastname: Glasser
authors.forename: Ana E
authors.initials: AE
authors.lastname: Markelz
authors.forename: Wendy C
authors.initials: WC
authors.lastname: Zera
authors.forename: Miriam L
authors.initials: ML
authors.lastname: Beckius
authors.forename: Katrin
authors.initials: K
authors.lastname: Mende
authors.forename: Clinton K
authors.initials: CK
authors.lastname: Murray
mesh_terms: D000284:Administration, Oral; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077525:Cefdinir; D002511:Cephalosporins / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D009582:Nitrofurantoin / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D014946:Wound Infection / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D019980:Amoxicillin-Potassium Clavulanate Combination; D009582:Nitrofurantoin; D000077525:Cefdinir; D012293:Rifampin