title: Xanthone natural products via N-heterocyclic carbene catalysis: total synthesis of atroviridin.
abstract: The total synthesis of atroviridin has been accomplished by a linear route involving the N-heterocyclic carbene (NHC)-catalyzed aroylation of the fluorobenzene derivative, Claisen cyclization of the O-propargylated benzophenones, and intramolecular 1,4-addition of the quinone intermediates. The result provides a viable route to xanthone natural products.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. suzuyumi@u-shizuoka-ken.ac.jp
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fukuta
authors.forename: Shinya
authors.initials: S
authors.lastname: Ota
authors.forename: Masayo
authors.initials: M
authors.lastname: Kamiya
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sato
mesh_terms: D016227:Benzoquinones / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D044004:Xanthones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D016227:Benzoquinones; D001688:Biological Products; D006571:Heterocyclic Compounds; D044004:Xanthones; C560830:atroviridin; C030011:carbene; C004532:quinone; D008697:Methane