title: Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat.
abstract: We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that β-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat.
authors.affiliation: Department of Surgery, Second Hospital of HeBei Medical University, School of Basic Medical Sciences, HeBei Medical University, Shijiazhuang 050000, PR China. biwei8115@sohu.com
authors.forename: Wei
authors.initials: W
authors.lastname: Bi
authors.forename: Yue
authors.initials: Y
authors.lastname: Bi
authors.forename: Ping
authors.initials: P
authors.lastname: Xue
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Wang
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Michele
authors.initials: M
authors.lastname: Baudy-Floc'h
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Ngerebara
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Li
authors.forename: K Michael
authors.initials: KM
authors.lastname: Gibson
authors.forename: Lanrong
authors.initials: L
authors.lastname: Bi
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology; D013237:Stereoisomerism; D014992:Xylenes / Q000037:antagonists & inhibitors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002243:Carbolines; D009842:Oligopeptides; D014992:Xylenes