title: Primary synovial sarcoma of the uterus.
abstract: We report a case of a 52-year-old female with synovial sarcoma of the uterine corpus. Grossly, the partly polypoid tumor involved the endometrium with invasion into the inner half of the myometrium. Histologically, the tumor showed biphasic structure with the predominance of poorly differentiated small to medium sized round to oval cells. These cells showed high nuclear to cytoplasmic ratio and were arranged in diffuse sheets. Other component consisted of larger epitheloid cells with ample eosinophilic cytoplasm arranged in irregular nests. These cells were only present in a small amount. Immunohistochemically, the tumor cells in both components showed the expression of EMA, S-100 protein, CD99, and NSE. RT-PCR analysis showed the presence of SYT-SSX1 fusion transcript. At present, the patient shows no signs of tumor relapse 56 months after the diagnosis. To the best of our knowledge, this is the first report of synovial sarcoma arising in uterus.
authors.affiliation: Department of Pathology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Studničkova 2, Prague 2, 12800, Czech Republic. pdundr@seznam.cz
authors.forename: Pavel
authors.initials: P
authors.lastname: Dundr
authors.forename: Daniela
authors.initials: D
authors.lastname: Fischerová
authors.forename: Ctibor
authors.initials: C
authors.lastname: Povýšil
authors.forename: Daniel
authors.initials: D
authors.lastname: Tvrdík
authors.forename: David
authors.initials: D
authors.lastname: Cibula
mesh_terms: D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology*; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000235:genetics / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger; C116512:SYT-SSX fusion protein