title: [Prolonged convulsion after intoxication of alachlor herbicide (Lasso): a case report].
abstract: We experienced a case of alachlor herbicide (Lasso) intoxication. A 57-year-old man was transported to our hospital by ambulance after ingesting 450 mL of Lasso. He was unconscious and had difficulty in breathing. Gastric lavage was performed after tracheal intubation and the patient was placed on mechanical ventilation. Activated charcoal and laxative were administrated. Even after admission, disturbance of consciousness persisted. He had liver and kidney disorders but these did not progress to multiple organ failure. He experienced convulsions from day 4 and was administered anticonvulsants. Convulsion was intractable and needed long-term treatment. His general condition improved until discharge. He was weaned from mechanical ventilation and recovered consciousness, but he still displayed tremors. The herbicide (Lasso) is a combination of alachlor and monochlorobenzene. Studies have shown that alachlor is neurotoxic and monochlorobenzene accumulates in the brain. In case of intoxication with the herbicide Lasso, treatment is required for ameliorating neurotoxic effects and intractable convulsion as well as liver and kidney disorders, gastrointestinal mucosal damage, hematopoietic disorder, and acute circulatory failure.
authors.affiliation: Tsuyama Central Hospital Emergency Center and Critical Care Unit.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Naito
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nagae
authors.forename: Shuji
authors.initials: S
authors.lastname: Okahara
authors.forename: Hiroki
authors.initials: H
authors.lastname: Maeyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Okada
authors.forename: Shingo
authors.initials: S
authors.lastname: Hagioka
authors.forename: Naoki
authors.initials: N
authors.lastname: Morimoto
mesh_terms: D000081:Acetamides / Q000506:poisoning*; D000927:Anticonvulsants / Q000008:administration & dosage; D002998:Clonazepam / Q000008:administration & dosage; D005751:Gastric Lavage; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000517:prevention & control; D012121:Respiration, Artificial; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D013874:Thiopental / Q000008:administration & dosage; D014635:Valproic Acid / Q000008:administration & dosage
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D006540:Herbicides; C000188:alachlor; D002998:Clonazepam; D014635:Valproic Acid; D013874:Thiopental