title: Synthesis and in vitro antitumor activity of new butenolide-containing dithiocarbamates.
abstract: Three series of butenolide-containing dithiocarbamates were designed and synthesized. Their anti-tumor activity in vitro was evaluated. Among them compound I-14 exhibited broad spectrum anti-cancer activity against five human cancer cell lines with IC(50) <30 μM. Structure-activity relationship analysis showed that the introduction of dithiocarbamate side chains on the C-3 position of butenolide was crucial for anti-tumor activity.
authors.affiliation: New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, PR China.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Wang
authors.forename: Hai-Wei
authors.initials: HW
authors.lastname: Xu
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Guo
authors.forename: Jia-Xin
authors.initials: JX
authors.lastname: Zheng
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
authors.forename: Xiao
authors.initials: X
authors.lastname: Guo
authors.forename: Chen-Xin
authors.initials: CX
authors.lastname: Zheng
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Liu
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013859:Thiocarbamates; C004511:butenolide; D015107:4-Butyrolactone