title: Pain, neuropathic symptoms, and physical and mental well-being in persons with cancer.
abstract: BACKGROUND
  Neuropathic pain is present in at least 25-40% of people with cancer pain and is thought to be more difficult to control than other types of cancer related pain.
  
  
  OBJECTIVE
  The purpose of this study was to explore differences in the experience of cancer patients who describe their pain using neuropathic descriptors compared to those who do not.
  
  
  METHODS
  A secondary analysis of data from 234 outpatients from a large NCI designated cancer center in west, central Florida was conducted to identify differences in pain, pain interference, symptoms, health related quality of life, and depression between the two groups.
  
  
  RESULTS
  Patients with numbness, tingling, or electric-like sensations reported higher levels of current pain (p= .001), pain at its worst (p= .001), pain on average (p= .019), pain at its least (p= .008), and pain interference (p< .001). They reported problems with dizziness/lightheadedness significantly more often (p=.004) and also reported more severe problems with concentration (p=.047), poorer physical (p=.019) and mental health (p=.024), although no differences in depressive symptoms were found.
  
  
  CONCLUSIONS
  The results of this study indicate that cancer patients with numbness, tingling, or electric-like sensations have significantly higher levels of pain and pain interference, and lower health related quality of life than do patients without these symptoms.
  
  
  CONCLUSIONS
  These results highlight the ongoing need for research evaluating methods of treating neuropathic pain; education regarding assessment and management of neuropathic pain; and aggressive efforts to relieve neuropathic pain in oncology settings.
authors.affiliation: University of South Florida College of Nursing, 12901 Bruce B. Downs Blvd, MDC22, Tampa, FL 33612, USA. ctofthag@health.usf.edu
authors.forename: Cindy S
authors.initials: CS
authors.lastname: Tofthagen
authors.forename: Susan C
authors.initials: SC
authors.lastname: McMillan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000523:psychology; D005260:Female; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000523:psychology; D010146:Pain / Q000209:etiology*; D010147:Pain Measurement; D010292:Paresthesia / Q000209:etiology; D011788:Quality of Life / Q000523:psychology; D012678:Sensation Disorders / Q000209:etiology*; D055815:Young Adult