title: Synthesis of 2-aziridinyl phosphonates by modified Gabriel-Cromwell reaction and their antibacterial activities.
abstract: A set of new aziridinyl phosphonates (4a-g) were synthesized by using the Gabriel-Cromwell reaction and its modified version developed in this study and their structures confirmed by HRMS, IR, and NMR spectra. All the compounds were screened for their antibacterial activity. They all showed comparable moderate to good growth inhibitory activity in reference to ampicillin and streptomycin.
authors.affiliation: Department of Chemistry, Middle East Technical University, 06531 Ankara, Turkey. dogano@metu.edu.tr
authors.forename: Özdemir
authors.initials: Ö
authors.lastname: Doğan
authors.forename: Hakan
authors.initials: H
authors.lastname: Babiz
authors.forename: Ayşe Gül
authors.initials: AG
authors.lastname: Gözen
authors.forename: Songül
authors.initials: S
authors.lastname: Budak
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001388:Aziridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013307:Streptomycin / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001388:Aziridines; D063065:Organophosphonates; D000667:Ampicillin; D013307:Streptomycin