title: Synthesis and hybridization data of oligonucleotide analogs with triazole internucleotide linkages, potential antiviral and antitumor agents.
abstract: Triazolyl-functionalized oligonucleotide (ON) analogs have received much attention as potential antitumor and antiviral agents. The most promising of such analogs are those exhibiting high binding affinity toward native DNA/RNA, since they may prove to be efficient antisense or siRNA agents. To date, relatively few ON analogs with triazole internucleotide linkages have been described. In this paper, we report an improved synthesis of a modified dinucleoside phosphoramidite and hybridization data of ON analogs with four-bond triazole internucleotide linkages. We believe these data are essential for comprehensive analysis of the relation between the length of triazole internucleotide linkages and duplex stability.
authors.affiliation: Engelhardt Institute of Molecular Biology, Vavilov str., 32, 119991 Moscow, Russia.
authors.forename: Anna
authors.initials: A
authors.lastname: Varizhuk
authors.forename: Alexandr
authors.initials: A
authors.lastname: Chizhov
authors.forename: Vladimir
authors.initials: V
authors.lastname: Florentiev
mesh_terms: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004247:DNA / Q000737:chemistry; D015394:Molecular Structure; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000378:metabolism; D009943:Organophosphorus Compounds; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009841:Oligonucleotides; D009943:Organophosphorus Compounds; D014230:Triazoles; C434331:phosphoramidite; D012313:RNA; D004247:DNA