title: Boronated unnatural cyclic amino acids as potential delivery agents for neutron capture therapy.
abstract: Boron delivery characteristics of cis and trans isomers of a boronated unnatural amino acid, 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC) were tested in the B16 mouse model for human melanoma. Both ABCPC isomers delivered comparable boron to B16 melanoma tumor cells as L-p-boronophenylalanine (BPA). Secondary ion mass spectrometry (SIMS) analysis revealed the presence of boron throughout the tumor from these compounds, and a near homogeneous distribution between the nucleus and cytoplasm of B16 cells grown in vitro. These encouraging observations support further studies of these new boron carriers in BNCT.
authors.affiliation: Departments of Radiology and Chemistry, The University of Tennessee, Knoxville, TN, USA.
authors.forename: George W
authors.initials: GW
authors.lastname: Kabalka
authors.forename: Aarif L
authors.initials: AL
authors.lastname: Shaikh
authors.forename: Rolf F
authors.initials: RF
authors.lastname: Barth
authors.forename: Tianyao
authors.initials: T
authors.lastname: Huo
authors.forename: Weilian
authors.initials: W
authors.lastname: Yang
authors.forename: Pamela M
authors.initials: PM
authors.lastname: Gordnier
authors.forename: Subhash
authors.initials: S
authors.lastname: Chandra
mesh_terms: D000598:Amino Acids, Cyclic / Q000737:chemistry*; D000818:Animals; D001895:Boron / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy; D005260:Female; D008546:Melanoma, Experimental / Q000532:radiotherapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D018629:Spectrometry, Mass, Secondary Ion
chemical_list: D000598:Amino Acids, Cyclic; D001895:Boron