title: A single blind controlled comparison of tramadol/paracetamol combination and paracetamol in hand and foot surgery. A prospective study.
abstract: The objective of this study was to compare the efficacy and effectiveness between an analgesic combination of tramadol/paracetamol (37.5+325 mg), and paracetamol monotherapy (1000 mg) for acute postoperative pain after hand and foot surgery. The study design was a single blind randomized controlled trial. A total of 114 patients who underwent hand and foot surgery under brachial plexus block were randomized to receive either paracetamol monotherapy (group P, n=57) or tramadol/paracetamol (group TP, n=57) postoperatively. The number of patients who required an extra-dose of analgesic pain score, and adverse affects were compared between the two groups. Analgesic requirement was significantly lower in those in the TP group when compared with the P group. In the TP group, the pain score after surgery was significantly lower than in the P group. Adverse effects did not significantly differ between the two groups. There were no serious adverse events in either group. The association of tramadol and paracetamol appears to have more efficacy when compared with paracetamol monotherapy for acute postoperative pain after hand and foot surgery.
authors.affiliation: Department of Plastic and Reconstructive Surgery, La Sapienza University of Rome, 00161 Rome, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Spagnoli
authors.forename: M I
authors.initials: MI
authors.lastname: Rizzo
authors.forename: A
authors.initials: A
authors.lastname: Palmieri
authors.forename: V
authors.initials: V
authors.lastname: Sorvillo
authors.forename: L
authors.initials: L
authors.lastname: Quadrini
authors.forename: N
authors.initials: N
authors.lastname: Scuderi
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D004890:Erythema / Q000139:chemically induced; D005260:Female; D005528:Foot / Q000601:surgery*; D006225:Hand / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D011537:Pruritus / Q000139:chemically induced; D016037:Single-Blind Method; D013514:Surgical Procedures, Operative / Q000009:adverse effects / Q000379:methods; D014147:Tramadol / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000082:Acetaminophen; D014147:Tramadol