title: Urea/thiourea derivatives of quinazolinone-lysine conjugates: synthesis and structure-activity relationships of a new series of antimicrobials.
abstract: Synthesis of a series of urea/thiourea/acetamide/sulphonamide derivatives of quinazolinones conjugated lysine has been reported. Structures of the products have been determined by standard spectroscopical studies. All the compounds have been screened for their antibacterial studies and structure-activity relationship has been developed. The activity profile revealed that the compounds containing urea and thiourea functionalities along with fluoro group have exerted a highly potent activity. Thus, the title compounds represent a novel class of potent antimicrobial agents.
authors.affiliation: Department of Studies in Chemistry, Manasagangotri, University of Mysore, Mysore 570 006, Karnataka, India.
authors.forename: G P
authors.initials: GP
authors.lastname: Suresha
authors.forename: R
authors.initials: R
authors.lastname: Suhas
authors.forename: Wethroe
authors.initials: W
authors.lastname: Kapfo
authors.forename: D Channe
authors.initials: DC
authors.lastname: Gowda
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008239:Lysine / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D052999:Quinazolinones / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D052999:Quinazolinones; D014508:Urea; D008239:Lysine