title: Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis.
abstract: BACKGROUND
  It is well known that lipids abnormally accumulate in the alveoli during idiopathic pulmonary alveolar proteinosis (PAP). It is unclear, however, whether lipids also abnormally accumulate in serum. This study investigated the serum lipid panels in idiopathic PAP patients and explored the relationships between serum levels and the severity of idiopathic PAP.
  
  
  RESULTS
  Clinical data including the level of serum lipids were evaluated in 33 non-diabetic idiopathic PAP patients and 157 healthy volunteers. Serum levels of triglyceride were higher in PAP patients than in healthy subjects (median: 192.00 mg/dl (P25: 104.36, P75: 219.00) vs 119.56 mg/dl (P25: 78.81, P75: 193.03), P < 0.05), while high-density lipoprotein cholesterol (HDL-C) levels were lower in patients than in the control group (42.50 ± 10.30 vs 51.34 ± 12.06 mg/dl, P < 0.01). Forced expiratory volume in one second and forced vital capacity in hypertriglyceridemia patients were lower than those in patients with normal triglyceride. Serum LDL-C and HDL-C ratio correlated negatively with PaO2 (r = -0.403, P < 0.05) and positively with lactate dehydrogenase (r = 0.381, P < 0.05).
  
  
  CONCLUSIONS
  PAP associates with high triglyceride and low HDL levels in the serum, and these lipids provide potential intervention strategy for treatment.
authors.affiliation: Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Xinlun
authors.initials: X
authors.lastname: Tian
authors.forename: Jinmei
authors.initials: J
authors.lastname: Luo
authors.forename: Kai-Feng
authors.initials: KF
authors.lastname: Xu
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.forename: Jiong
authors.initials: J
authors.lastname: Zhou
authors.forename: Ruie
authors.initials: R
authors.lastname: Feng
authors.forename: Yaosong
authors.initials: Y
authors.lastname: Gui
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Wenbing
authors.initials: W
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yuanjue
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011649:Pulmonary Alveolar Proteinosis / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D011650:Pulmonary Alveoli / Q000378:metabolism*; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood; D014797:Vital Capacity
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D010100:Oxygen