title: New treatment of free-radical scavenger in adrenoleukodystrophy.
abstract: OBJECTIVE
  Adrenoleukodystrophy (ALD) is an X-linked disorder and characterized by the accumulation of saturated very long-chain fatty acids. Treatment is still unsatisfactory. Our objective is to report on the effect of the free-radical scavenger, edaravone, in a patient with ALD.
  
  
  METHODS
  The patient was given edaravone intravenously twice. D-ROM in cerebral spinal fluid decreased dramatically, and a shortening of neuronal transmission time as estimated on somatosensory evoked potential was observed. After terminating the treatment, his symptoms progressively reappeared.
  
  
  CONCLUSIONS
  This is the first report of the use of edaravone in ALD. The drug is apparently effective in improving symptoms of ALD and should be evaluated more formally.
authors.affiliation: Department of Paediatrics, Tokyo Medical University, Tokyo, Japan. hisashi@tokyo-med.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Kawashima
authors.forename: S
authors.initials: S
authors.lastname: Nishimata
authors.forename: C
authors.initials: C
authors.lastname: Ishii
authors.forename: G
authors.initials: G
authors.lastname: Yamanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Kashiwagi
authors.forename: K
authors.initials: K
authors.lastname: Takekuma
authors.forename: A
authors.initials: A
authors.lastname: Hoshika
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000326:Adrenoleukodystrophy / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D000983:Antipyrine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002648:Child; D000077553:Edaravone; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D016166:Free Radical Scavengers / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009474:Neurons / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000134:cerebrospinal fluid; D009435:Synaptic Transmission / Q000187:drug effects; D034941:Upper Extremity / Q000294:innervation
chemical_list: D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D000077553:Edaravone; D000983:Antipyrine