title: Genome-wide association studies in pediatric endocrinology.
abstract: Genome-wide association (GWA) studies are a powerful tool for understanding the genetic underpinnings of human disease. In this article, we briefly review the role and findings of GWA studies in type 1 diabetes, stature, pubertal timing, obesity, and vitamin D deficiency. We then discuss the present and future implications of these findings with regards to disease prediction, uncovering basic biology, and the development of novel therapeutic agents.
authors.affiliation: Division of Endocrinology, Children's Hospital Boston, Boston, MA 02115, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Dauber
authors.forename: Joel N
authors.initials: JN
authors.lastname: Hirschhorn
mesh_terms: D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D004704:Endocrinology / Q000379:methods* / Q000639:trends; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D009765:Obesity / Q000235:genetics; D010372:Pediatrics / Q000379:methods* / Q000639:trends; D011627:Puberty / Q000235:genetics / Q000502:physiology; D014808:Vitamin D Deficiency / Q000235:genetics