title: Adult survivors of invasive pneumococcal disease exhibit defective B cell function.
abstract: Adults who have recovered from an episode of invasive pneumococcal disease demonstrate defective B cell activation in response to αδ-dex, a polyclonal polysaccharide mimic, compared with matched control subjects. The defect is not overcome by CD4(+) T cell assistance and may explain the relatively poor response to pneumococcal vaccination in survivors of invasive pneumococcal disease.
authors.affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, South Yorkshire, UK.
authors.forename: Tom C
authors.initials: TC
authors.lastname: Darton
authors.forename: James B
authors.initials: JB
authors.lastname: Wing
authors.forename: Andrew
authors.initials: A
authors.lastname: Lees
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Heath
authors.forename: Robert C
authors.initials: RC
authors.lastname: Read
mesh_terms: D000293:Adolescent; D000328:Adult; D000955:Antigens, T-Independent / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D016470:Bacteremia / Q000276:immunology* / Q000382:microbiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000276:immunology* / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000472:pathogenicity*; D055815:Young Adult
chemical_list: D000955:Antigens, T-Independent