title: Different association of circulating levels of adipocyte and epidermal fatty acid-binding proteins with metabolic syndrome and coronary atherosclerosis in Chinese adults.
abstract: OBJECTIVE
  Adipocyte and epidermal fatty acid-binding protein (A-FABP, E-FABP) are cytoplasmic proteins which may play an important role in metabolic diseases. In the present study, we investigated the different association of A-FABP and E-FABP with metabolic syndrome (MetS) and coronary artery disease (CAD) in Chinese adults.
  
  
  METHODS
  A total of 459 subjects (233 MetS and 226 non-MetS) who had undergone coronary angiography were enrolled in the present study. Serum A-FABP and E-FABP levels, glucose, lipid profiles and other biochemical markers were measured.
  
  
  RESULTS
  Both serum A-FABP and E-FABP levels were significantly higher in the MetS group than in the non-MetS group (P = 0.040 and 0.045, respectively). Only serum A-FABP levels in the CAD group were significantly higher than in the non-CAD group (12.30 ± 5.45 vs.10.94 ± 4.94 ng/mL, P= 0.008), and significantly increased with the increasing of number of disease vessels (P=0.004). Serum A-FABP levels were also associated with risk of CAD (odds ratio 2.956 [1.295-6.748]; P = 0.010). Adjusting for age, sex, and other conventional risk factors for CAD did not appreciably change the results. No difference was found in serum E-FABP levels between CAD status. Serum E-FABP levels were correlated with fasting and post load 2h plasma glucose, HbA1c, serum total cholesterol and LDL-C concentrations while serum A-FABP levels were correlated with fasting and post load 2h serum insulin concentrations and HOMA-IR (different P<0.05).
  
  
  CONCLUSIONS
  Our data indicated while both serum A-FABP and E-FABP levels had associations with MetS, only A-FABP was significantly associated with increased risk of CAD in Chinese adults.
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU) and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Hong
authors.forename: Weiqiong
authors.initials: W
authors.lastname: Gu
authors.forename: Yifei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qun
authors.initials: Q
authors.lastname: Yan
authors.forename: Meng
authors.initials: M
authors.lastname: Dai
authors.forename: Juan
authors.initials: J
authors.lastname: Shi
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhai
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Li
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood*; D003593:Cytoplasm / Q000378:metabolism; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D012306:Risk; D012307:Risk Factors
chemical_list: C493410:FABP4 protein, human; C493412:FABP5 protein, human; D050556:Fatty Acid-Binding Proteins