title: New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies.
abstract: It is well known that Bone morphogenetic proteins (BMPs) induce bone formation and that some BMPs, including BMP2 and BMP7, are clinically used in orthopedics. Signaling by BMPs plays an important role in a variety of cell-types in bone such as osteoblasts, chondrocytes, and osteoclasts. It is recently reported using an osteoblast-targeted deletion of BMP signaling that BMP signaling in osteoblasts physiologically induces bone resorption by enhancing osteoclastogenesis via the RANKL-OPG pathway and reduces bone mass. In this review, the physiological function of BMP signaling in bone will be focused, and the current outcomes from mouse genetic studies will be discuss.
authors.affiliation: Center for Excellence in Hip Disorders, Texas Scottish Rite Hospital for Children, Dallas, TX, USA. Nobby.Kamiya@tsrh.org
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kamiya
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mishina
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins