title: Prognostic implications of cimetidine on advanced serous ovarian carcinoma related to cyclooxygenase-2 expression.
abstract: This study was performed to identify the contribution of cimetidine to chemotherapy for epithelial ovarian carcinoma. Cimetidine was administered two weeks before surgery in combination with platinum-based chemotherapy, and the treatment was continued for two years. Cyclooxygenase-2 (COX-2) expression was also evaluated. The chemotherapy regimens did not affect patient prognosis. The effect of cimetidine was more marked in patients who showed overexpression of COX-2. Platinum-based chemotherapy combined with cimetidine, as a first-line therapy, may improve the prognosis of patients with advanced serous ovarian carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. kniwa@gifu-u.ac.jp.
authors.forename: Kenji
authors.initials: K
authors.lastname: Niwa
authors.forename: Kokyo
authors.initials: K
authors.lastname: Onogi
authors.forename: Yun
authors.initials: Y
authors.lastname: Wu
authors.forename: Hideki
authors.initials: H
authors.lastname: Mori
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Inoue
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Tamaya