title: Brown tumor--a rare manifestation of renal osteodystrophy and severe secondary hyperparathyroidism: case report.
abstract: Multifactorial disorders in mineral metabolism and bone structure occur early in the course of chronic kidney disease. The new term of 'chronic kidney disease--mineral and bone disorders' has been used to encompass a broad syndrome in which various abnormalities in bone and mineral metabolism are present in patients with chronic kidney disease. Brown tumors are an uncommon type of bone lesions that represent a focal manifestation of high-turnover bone disease. In our report, we describe a patient with chronic kidney disease on chronic hemodialysis that presented with multiple osseous lesions of the right elbow, right scapula and ribs. This case illustrates the importance of taking brown tumor in consideration in differential diagnosis and management of patients with an osseous mass and chronic kidney disease, where a failure to establish an accurate diagnosis can lead to unnecessary further diagnostic procedures and even extensive surgery, increasing the morbidity of these patients. Prevention, early diagnosis and treatment of secondary hyperparathyroidism are important in reducing the prevalence of high-turnover bone disease and consequential bone lesions including brown tumors.
authors.affiliation: Department of Gastroenterology, Sestre milosrdnice University Hospital, Zagreb, Croatia. neven.barsic@gmail.com
authors.forename: Neven
authors.initials: N
authors.lastname: Barsić
authors.forename: Kresimir
authors.initials: K
authors.lastname: Cala
authors.forename: Drasko
authors.initials: D
authors.lastname: Pavlović
mesh_terms: D001859:Bone Neoplasms / Q000150:complications / Q000175:diagnosis*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000150:complications; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary