title: Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis.
abstract: Bergenin pentacetate (2), a peracetate derivative of biologically active lead compound Bergenin (1) isolated from Bergenia stracheyi was subjected to lipase catalyzed regioselective alcoholysis to obtain 3,4,10,11-tetracetate of Bergenin (3). The free hydroxyl group of 3 was derivatised using higher carboxylic acids to obtain acyl derivatives (4-7). These compounds synthesized via chemoenzymatic route were characterized using 1H NMR, 13C NMR and mass spectral data and evaluated for DPPH radical scavenging, antimicrobial and xanthine oxidase inhibitory activities. The studies revealed that biological activity of Bergenin can be optimized by selective modification of its structure.
authors.affiliation: Department of Chemistry, Islamia College of Science and Commerce, Srinagar 190002, J&K, India. nighat052000@yahoo.com.au
authors.forename: Nighat
authors.initials: N
authors.lastname: Nazir
authors.forename: Surrinder
authors.initials: S
authors.lastname: Koul
authors.forename: Mushtaq Ahmad
authors.initials: MA
authors.lastname: Qurishi
authors.forename: Muzaffar Hussain
authors.initials: MH
authors.lastname: Najar
authors.forename: Mohammed Iqbal
authors.initials: MI
authors.lastname: Zargar
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001578:Benzopyrans / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D055162:Biocatalysis; D001713:Biphenyl Compounds / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000378:metabolism; D008049:Lipase / Q000737:chemistry / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010851:Picrates / Q000378:metabolism; D031995:Saxifragaceae / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001578:Benzopyrans; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D014969:Xanthine Oxidase; D008049:Lipase; C006741:bergenin