title: Potentially functional polymorphisms in IL-23 receptor and risk of esophageal cancer in a Chinese population.
abstract: Interleukin-23 (IL-23)/IL-23 receptor (IL-23R) is essential for Th17 cell-mediated immune response, involved in autoimmune diseases and cancer pathogenesis. Two potentially functional genetic single nucleotide polymorphisms (SNPs; IL-23R rs6682925 T>C and rs1884444 T>G) were found to contribute to cancer susceptibility. In our study, we conducted a case-control study including 1,645 patients with esophageal cancer and 1,694 cancer-free controls in a Chinese population to assess the association between the two SNPs and the risk of esophageal cancer. We found that IL-23R rs6682925 TC/CC and rs1884444 TG/GG variant genotypes were associated with significantly increased risk of esophageal cancer [rs1884444: adjusted odds ratio (OR) = 1.16, 95% confidence intervals (CIs) =1.01-1.33; rs6682925: adjusted OR = 1.23, 95% CIs = 1.07-1.42], compared to their corresponding wild-type homozygotes. Furthermore, the increased risks associated with the two SNPs were independent from smoking and alcohol drinking status. These findings indicated that genetic variants in IL-23R may contribute to esophageal cancer risk in our Chinese population.
authors.affiliation: Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Chu
authors.forename: Weike
authors.initials: W
authors.lastname: Cao
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Shandong
authors.initials: S
authors.lastname: Pan
authors.forename: Yong
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yao
authors.initials: Y
authors.lastname: Liu
authors.forename: Haiyong
authors.initials: H
authors.lastname: Gu
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Hu
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*; D012307:Risk Factors
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin