title: [Evaluation of magnetic resonance signal intensity in bone marrow after administration of super paramagnetic iron oxide (SPIO)].
abstract: Super paramagnetic iron oxide (SPIO) is taken up in the bone marrow and lymph nodes, as well as by the liver. Focusing on the intervertebral disks, which are unaffected by contrast effects, we examined the relationship between magnetic resonance image (MRI) signal intensity after SPIO uptake in the vertebral body and intervertebral disks and investigated MRI signal intensity in bone marrow metastases and osteomyelitic (inflammatory) lesions after SPIO uptake by bone marrow. The lumbar spine was imaged in 5 healthy volunteers (age range, 26-48 years). A specified amount of SPIO was administered intravenously, and signal intensities before and after administration were measured. The signal intensity ratio with respect to the value before administration was calculated, and quantitative signal analysis was conducted. A similar investigation was performed in patients with bone metastasis and osteomyelitis. As a result of the metastasis, the signal intensity ratio showed a low value in comparison with normal marrow, and the osteomyelitis showed a high value in comparison with normal marrow. We report the usefulness of evaluations of changes in marrow signal intensity using SPIO in MRI.
authors.affiliation: Department of Clinical Radiology, Hyogo College of Medicine.
authors.forename: Noriko
authors.initials: N
authors.lastname: Kotoura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Reiichi
authors.initials: R
authors.lastname: Ishikura
authors.forename: Takuya
authors.initials: T
authors.lastname: Enoki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamashita
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakae
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow; D019046:Bone Marrow Neoplasms / Q000175:diagnosis / Q000556:secondary; D003287:Contrast Media; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage; D006801:Humans; D007403:Intervertebral Disc; D008159:Lumbar Vertebrae; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000175:diagnosis; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide