title: Disulfide core cross-linked PEGylated polypeptide nanogel prepared by a one-step ring opening copolymerization of N-carboxyanhydrides for drug delivery.
abstract: A novel disulfide core cross-linked PEGylated polypeptide nanogel has been synthesized by a one-step ring opening copolymerization of γ-benzyl L-glutamate N-carboxyanhydride and L-cystine N-carboxyanhydride using an amino group-terminated poly(ethylene glycol) methyl ether as initiator. Characterization of products confirms the formation of a core cross-linked PEGylated nanogel with disulfide linkages with a size of about 250 nm, and these studies also confirm that this nanogel can easily be broken by glutathione. Cell viability experiments show the good biocompatibility of the as-prepared polymer. Studies relating to loading and controlled release of indomethacin under reduction-sensitive conditions reveal that the nanogel is a good candidate for drug delivery systems.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the micrometer-scale and Department of Chemical Physics, University of Science and Technology of China, Hefei, 230026, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xing
authors.forename: Bin
authors.initials: B
authors.lastname: Lai
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Ye
authors.forename: Lifeng
authors.initials: L
authors.lastname: Yan
mesh_terms: D000812:Anhydrides / Q000737:chemistry; D003553:Cystine / Q000031:analogs & derivatives / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry*; D016503:Drug Delivery Systems; D005971:Glutamates / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007213:Indomethacin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D000080385:Nanogels; D049329:Nanostructures / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011094:Polyethyleneimine / Q000138:chemical synthesis* / Q000737:chemistry; D058105:Polymerization; D013050:Spectrometry, Fluorescence
chemical_list: D000812:Anhydrides; D004220:Disulfides; D005971:Glutamates; D000080385:Nanogels; D010455:Peptides; C568828:cystine-N-carboxy anhydride; C568827:gamma-benzylglutamyl-N-carboxy anhydride; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D003553:Cystine; D011094:Polyethyleneimine; D005978:Glutathione; D007213:Indomethacin