title: Clinical Neisseria gonorrhoeae isolates in the United States with resistance to azithromycin possess mutations in all 23S rRNA alleles and the mtrR coding region.
abstract: We identified strains of Neisseria gonorrhoeae in San Diego County, California, that possess high levels of resistance to azithromycin (8.0-16.0 μg/ml MIC). These isolates contain a combination of mutations in both the 23S rRNA loci and mtrR genes. This is the first description of such isolates in the United States.
authors.affiliation: San Francisco Department of Public Health Laboratory, San Francisco, California 94102, USA.
authors.forename: Abel
authors.initials: A
authors.lastname: Wu
authors.forename: Sean
authors.initials: S
authors.lastname: Buono
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Katz
authors.forename: Mark W
authors.initials: MW
authors.lastname: Pandori
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017963:Azithromycin / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D009154:Mutation; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D009876:Operon / Q000235:genetics; D011401:Promoter Regions, Genetic; D012338:RNA, Ribosomal, 23S / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D012338:RNA, Ribosomal, 23S; D012097:Repressor Proteins; C087450:mtrR protein, Neisseria gonorrhoeae; D017963:Azithromycin