title: Multicomponent synthesis of fused benzimidazolopiperazines.
abstract: We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclization, and an oxidation.
authors.affiliation: Laboratoire Chimie et procédés, UMR 7652-DCSO-Ecole Polytechnique-ENSTA, Ecole Nationale Supérieure de Techniques Avancées, Paris, France. laurent.elkaim@ensta-paristech.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: El Kaïm
authors.forename: Laurence
authors.initials: L
authors.lastname: Grimaud
authors.forename: Srinivas Reddy
authors.initials: SR
authors.lastname: Purumandla
mesh_terms: D000080:Acetals / Q000737:chemistry; D001562:Benzimidazoles / Q000737:chemistry*; D003500:Cyclization; D009596:Nitrophenols / Q000737:chemistry; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000080:Acetals; D001562:Benzimidazoles; D009596:Nitrophenols; D010879:Piperazines; C031000:benzimidazole