title: Functional disability profiles in amnestic mild cognitive impairment.
abstract: OBJECTIVE
  Instrumental activities of daily living (IADL) can be impaired in mild cognitive impairment (MCI), and the severity of functional disability predicts Alzheimer's disease (AD) in amnestic MCI (aMCI). This study investigated the functional profiles of aMCI in a Chinese population.
  
  
  METHODS
  The Disability Assessment for Dementia scores of 56 subjects with single-domain aMCI (sd-aMCI) and 94 with multiple-domain aMCI (md-aMCI) were compared with normal controls (n = 64) and mild AD patients (n = 102).
  
  
  RESULTS
  Both the sd-aMCI (2.5 ± 2.5) and md-aMCI (3.7 ± 3.5) groups had more impaired IADL items than the controls (0.7 ± 1.7). Their IADL scores were intermediate, between the control and AD groups. sd-aMCI subjects presented deficits in 7 IADL items involving the 'meal preparation', 'telephoning', 'finance', 'medications', 'housework', and 'leisure' subscales. md-aMCI subjects presented deficits in 14 IADL items involving all subscales of daily activities. The Mini-Mental State Examination and Modified Trail-Making Test Part B scores were the major neuropsychological correlates of IADL performance in aMCI.
  
  
  CONCLUSIONS
  IADL can be impaired in both sd-aMCI and md-aMCI. Including the functional ability assessment in the evaluation of aMCI may help clinicians to provide appropriate suggestions to maintain daily functioning.
authors.affiliation: Division of Neurology, Department of Internal Medicine, Far-Eastern Memorial Hospital, New Taipei, Taiwan, ROC.
authors.forename: Yen-Chi
authors.initials: YC
authors.lastname: Yeh
authors.forename: Ker-Neng
authors.initials: KN
authors.lastname: Lin
authors.forename: Wei-Ta
authors.initials: WT
authors.lastname: Chen
authors.forename: Chi-Ying
authors.initials: CY
authors.lastname: Lin
authors.forename: Ting-Bin
authors.initials: TB
authors.lastname: Chen
authors.forename: Pei-Ning
authors.initials: PN
authors.lastname: Wang
mesh_terms: D000203:Activities of Daily Living; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D000647:Amnesia / Q000150:complications* / Q000523:psychology; D044466:Asian People; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000150:complications* / Q000523:psychology; D004185:Disability Evaluation; D018450:Disease Progression; D006801:Humans; D008609:Mental Status Schedule; D011237:Predictive Value of Tests; D012016:Reference Values; D012720:Severity of Illness Index