title: Retrograde transport: two (or more) roads diverged in an endosomal tree?
abstract: Some proteins and lipids traffic from the plasma membrane to the trans Golgi network (TGN)/Golgi apparatus and the endoplasmic reticulum, via the retrograde transport route. Endosomes are an obligatory through station. Whether early, recycling and late endosomes all hand off material to the TGN have remained a matter of debate. In this review, we give a short historical overview on how retrograde transport was discovered and explored. We then summarize and critically discuss data that have been put forward in favour of the existence of trafficking interfaces between each of the different endocytic localizations and the TGN. We finally point out some conceptual and technological challenges that will have to be met to establish definite conclusions for each of these scenarios.
authors.affiliation: Traffic, Signaling, and Delivery Laboratory, Centre de Recherche, Institut Curie, CNRS UMR144, 26 rue d'Ulm, 75248 Paris Cedex 05, France. ludger.johannes@curie.fr
authors.forename: Ludger
authors.initials: L
authors.lastname: Johannes
authors.forename: Christian
authors.initials: C
authors.lastname: Wunder
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D021381:Protein Transport; D021601:trans-Golgi Network / Q000378:metabolism*
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport