title: [Action of red polarized light on the acupuncture point E-36 increases analgesic effect of corvitin].
abstract: In experiments on mice of lines C57BL/6J and CBA/CaLac, the possibility of strengthening of analgesic effect of corvitin by the action of red polarized light (PL) on the acupoint (AP) E-36 was studied. The pain behavioral response (licking of the painful area) was caused by injection of 5% formalin in hind limb (0.25 microl subcutaneously). The duration of pain response was studied before and after systemic introduction of corvitin (10 mg/kg, intraperitoneal) or joint use of corvitin and red PL (10 minute session). It is established, that after application of red PL on the antinociceptive AP E-36 in all animals an authentic strengthening of antinociceptive effect of corvitin takes place. In C57BL/6J mice, application of corvitin alone weakened the pain response by 29.7% and during combined use of red PL and corvitin, it grew up to 53.1%. Mice of line CBA/CaLac were less sensitive both to corvitin, and PL. In this line, corvitin used alone reduced the duration of pain response by 14%, and by 32.4% during combined use with red PL. Non-traumatic, without side effects, the method of influence by low-intensive PL can be recommended to patients accepting corvitin for strengthening its efficiency.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Tamarova
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Lymans'kyĭ
authors.forename: O I
authors.initials: OI
authors.lastname: Kostiuk
authors.forename: V A
authors.initials: VA
authors.lastname: Mitruzaeva
authors.forename: L I
authors.initials: LI
authors.lastname: Lymans'ka
mesh_terms: D015669:Acupuncture Points; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000528:radiation effects; D003131:Combined Modality Therapy; D005419:Flavonoids / Q000008:administration & dosage / Q000627:therapeutic use*; D008027:Light; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010146:Pain / Q000188:drug therapy; D059408:Pain Management; D010147:Pain Measurement; D017288:Pain Threshold; D013045:Species Specificity
chemical_list: D000700:Analgesics; D005419:Flavonoids; C558416:corvitin