title: Predictors of global left ventricular function in metabolic syndrome.
abstract: BACKGROUND
  The metabolic syndrome (MS) represents a cluster of cardiovascular risk factors that act synergistically.
  
  
  OBJECTIVE
  The aim of this study was to determine which parameters were independently associated with the global left ventricular (LV) function in subjects with MS estimated with the Tei index.
  
  
  METHODS
  The study included 234 subjects with MS and 96 controls adjusted by age. MS was defined by the presence of three or more of ATP- NCEP III criteria. All subjects underwent laboratory blood tests and two-dimensional, pulsed and tissue Doppler echocardiography. Appropriate tissue Doppler time intervals for the estimation of the Tei index were also assessed.
  
  
  RESULTS
  The Tei index was increased in subjects with MS (0.35 ± 0.05 vs 0.49 ± 0.10, p < 0.001). Multiple regression analysis of the clinical parameters showed that systolic blood pressure (β= 0.289, p < 0.001), fasting glucose (β= 0.205, p = 0.009), LV mass index (β= 0.301, p < 0.001), E/e'(septal) (β= 0.267, p < 0.001), and e'(septal) (β= -0.176, p = 0.011) were independently associated with the global left ventricular function estimated by Tei index.
  
  
  CONCLUSIONS
  MS has a significant impact on LV global function. Systolic blood pressure, fasting glucose, LV mass index, E/e'(septal), and e'(septal) were independently associated with the LV global function.
authors.affiliation: Clinic for Cardiology, Clinical Centre of Serbia, Belgrade, Serbia. lole@scnet.rs
authors.forename: Branislava Aleksa
authors.initials: BA
authors.lastname: Ivanovic
authors.forename: Marijana Vaso
authors.initials: MV
authors.lastname: Tadic
authors.forename: Dragan Vojislav
authors.initials: DV
authors.lastname: Simic
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D001786:Blood Glucose