title: Solubility enhancement and physicochemical characterization of carvedilol solid dispersion with Gelucire 50/13.
abstract: The objective of the study was enhancement of dissolution of poorly soluble carvedilol by solid dispersions (SDs) with Gelucire 50/13 using solvent evaporation method. The solubility of carvedilol showed linear increase with increasing concentrations of Gelucire indicating A(L) type solubility diagrams. SDs characterized for physicochemical characteristics using differential scanning calorimetry and X-ray diffractometry revealed transformation of crystalline form of drug to amorphous form which was confirmed by scanning electron micrographs. Further fourier transform infrared spectroscopy results suggested there is no drug carrier interaction. From the dissolution parameters such as mean dissolution time, dissolution efficiency and drug release rate, improved dissolution characteristics for SDs were observed compared with physical mixture and pure drug. Thus SDs of carvedilol in Gelucire 50/13 showed enhanced solubility and dissolution rate compared to pure drug.
authors.affiliation: Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, Vidyanagar, Warangal, AP, India.
authors.forename: Raja Hemanth Kumar
authors.initials: RH
authors.lastname: Potluri
authors.forename: Suresh
authors.initials: S
authors.lastname: Bandari
authors.forename: Raju
authors.initials: R
authors.lastname: Jukanti
authors.forename: Prabhakar Reddy
authors.initials: PR
authors.lastname: Veerareddy
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002227:Carbazoles / Q000008:administration & dosage / Q000737:chemistry*; D000077261:Carvedilol; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry*; D005223:Fats / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D009821:Oils / Q000737:chemistry*; D011412:Propanolamines / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D014961:X-Ray Diffraction
chemical_list: D000959:Antihypertensive Agents; D002227:Carbazoles; D004337:Drug Carriers; D005223:Fats; D009821:Oils; D011412:Propanolamines; D000077261:Carvedilol; C071184:Gelucire 50-13