title: Immediate release of ibuprofen from Fujicalin®-based fast-dissolving self-emulsifying tablets.
abstract: BACKGROUND
  Drug release from a solid form of self-emulsifying drug delivery system (SEDDS) has greatly been limited due to strong adsorption and physical interaction with carriers. To facilitate drug release process in the stomach, an acid-soluble powderizing carrier, Fujicalin(®) was evaluated together with different disintegrants and hydrophilic lubricants.
  
  
  METHODS
  Immediate-release self-emulsifying tablets (IR-SETs) of ibuprofen (IBU) was prepared with solidified SEDDS of IBU, various disintegrants, and lubricants, and drug release was evaluated to develop IR-SET that can release IBU with a similar IBU release rate to that obtained with liquid SEDDS.
  
  
  RESULTS
  The liquid SEDDS consisted of Capryol 90, Cremophor EL, Labrasol, and IBU at a ratio of 3:4:3:3, and was solidified with various adsorbents. The powderized SEDDS was tabletted by a direct compression. Fujicalin(®)-based SEDDS tablets demonstrated remarkably higher dissolution rate of IBU compared with Neusilin(®) and Neosyl(®)-based SEDDS tablets. The IR-SET formula of IBU prepared with Fujicalin(®) as an adsorbent, Polyplasdone(®) as a disintegrant, and sodium bicarbonate as a co-disintegrant showed over 90% of initially loaded dose of IBU released within 5 min in a stimulated gastric juice (pH 1.2), exhibiting almost equivalent rate of IBU release to that shown by liquid SEDDS. The particle size analysis revealed no significant differences in droplet sizes of the microemulsions formed from liquid (116 nm) and IR-SET (110 nm).
  
  
  CONCLUSIONS
  The novel IR-SET can be promising as a fast-releasing SEDDS tablet of IBU for fast onset of action.
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea.
authors.forename: Myung Joo
authors.initials: MJ
authors.lastname: Kang
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Jung
authors.forename: Woo Heon
authors.initials: WH
authors.lastname: Song
authors.forename: Jun Sang
authors.initials: JS
authors.lastname: Park
authors.forename: Sung-Up
authors.initials: SU
authors.lastname: Choi
authors.forename: Kyung Taek
authors.initials: KT
authors.lastname: Oh
authors.forename: Hyung-Kyoon
authors.initials: HK
authors.lastname: Choi
authors.forename: Young Wook
authors.initials: YW
authors.lastname: Choi
authors.forename: Jaehwi
authors.initials: J
authors.lastname: Lee
authors.forename: Beom-Jin
authors.initials: BJ
authors.lastname: Lee
authors.forename: Sang-Cheol
authors.initials: SC
authors.lastname: Chi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D001682:Biological Availability; D002130:Calcium Phosphates / Q000737:chemistry*; D016503:Drug Delivery Systems; D045703:Emulsifying Agents / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D013607:Tablets
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002130:Calcium Phosphates; D045703:Emulsifying Agents; D004655:Emulsions; D013607:Tablets; C452280:fujicalin; D007052:Ibuprofen