title: Effects of donepezil on behavioral manifestations of thalamic infarction: a single-case observation.
abstract: OBJECTIVE
  To examine the effect of donepezil for the treatment of cognitive and behavioral disorders associated with thalamic lesions in a 45-year-old male who suffered an infarct in the left thalamus.
  
  
  BACKGROUND
  Recent studies suggest that donepezil may improve executive functions impairments due to subcortical ischemic lesions.
  
  
  METHODS
  The effects of donepezil were analyzed in a single-case of thalamic infarction with cognitive and behavioral alterations in an open label study.
  
  
  RESULTS
  Significant behavioral modifications related to improved performances in executive functions were observed with the treatment.
  
  
  CONCLUSIONS
  The results suggest that donepezil may have significant effect on executive functions that can alter behavioral outcomes after thalamic infarctions.
authors.affiliation: Cognitive Neurology and Dementia Unit, Neurology Service, El Salvador Hospital Santiago, Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Riveros
authors.forename: Hughes
authors.initials: H
authors.lastname: Chabriat
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Flores
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Alvarez
authors.forename: Andrea
authors.initials: A
authors.lastname: Slachevsky