title: Primary malignant melanoma of the esophagus: a clinicopathologic study of a case with comprehensive literature review.
abstract: Primary malignant melanoma originating in the digestive tract is particularly rare, mainly affecting the anorectum and oral cavity. Primary malignant melanoma of the esophagus has been the subject mostly of case reports. This tumor has a dismal prognosis with a frequency estimated to be approximately 0.1% to 0.2% of all esophageal malignancies. According to the review by Volpin et al of November 2002, 238 cases of primary malignant melanoma of the esophagus have been published up to early 2001. We present an additional case of primary malignant melanoma of the esophagus of the amelanotic variant in a 69-year-old man. The patient was preoperatively investigated by esophageal endoscopy and endoscopic ultrasound. The surgically resected tumor specimen was examined histologically and supplemented by immunohistochemical and ultrastructural analysis. Intra-abdominal relapse occurred after 8 months at the site of surgery, necessitating repeat resection. The patient died of advanced intra-abdominal disease 14 months after the primary diagnosis. A comprehensive computerized (PubMed/Medline) review of the world literature was also carried out and 99 additional cases (after the review by Volpin et al) were found, 9 of them from the 1990s which escaped previous tabulations, and 90 from the years 2000 to 2010, amounting to a grand total of 337 ever published.
authors.affiliation: Department of Pathology, Division of Anatomic Pathology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy. bismi@libero.it
authors.forename: Michele
authors.initials: M
authors.lastname: Bisceglia
authors.forename: Francesco
authors.initials: F
authors.lastname: Perri
authors.forename: Antonio
authors.initials: A
authors.lastname: Tucci
authors.forename: Matteo
authors.initials: M
authors.lastname: Tardio
authors.forename: Gaetano
authors.initials: G
authors.lastname: Panniello
authors.forename: Giulia
authors.initials: G
authors.lastname: Vita
authors.forename: Gianandrea
authors.initials: G
authors.lastname: Pasquinelli
mesh_terms: D000368:Aged; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D004947:Esophagus / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local