title: Early stages of mesothelioma, screening and biomarkers.
abstract: The early diagnosis of mesothelioma is notoriously difficult, both from a clinical and pathological perspective. Patients often undergo several medical investigations without definitive diagnosis. The discovery of biomarkers that can be assessed in pleural effusions, histological samples, and serum may assist with the difficult early diagnosis of mesothelioma. In this chapter we focus on those markers that have been examined in the setting of either early diagnosis of mesothelioma in symptomatic individuals or that have been proposed as suitable for screening of asbestos-exposed individuals, with an emphasis on cytology and histology.
authors.affiliation: Department of Anatomical Pathology, Flinders University of South Australia, Adelaide, SA, Australia. sonja.klebe@health.sa.gov.au
authors.forename: Sonja
authors.initials: S
authors.lastname: Klebe
authors.forename: Douglas W
authors.initials: DW
authors.lastname: Henderson
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020346:Aquaporins / Q000032:analysis; D001194:Asbestos / Q000633:toxicity; D014408:Biomarkers, Tumor / Q000032:analysis*; D018394:CA-125 Antigen / Q000097:blood; D019002:CD56 Antigen / Q000032:analysis; D042241:Early Diagnosis; D058851:GPI-Linked Proteins / Q000032:analysis; D020869:Gene Expression Profiling; D051272:Glucose Transporter Type 1 / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis; D008565:Membrane Proteins / Q000097:blood; D008654:Mesothelioma / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D018396:Mucin-1 / Q000032:analysis; D009367:Neoplasm Staging; D053495:Osteopontin / Q000097:blood; D010997:Pleural Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000627:therapeutic use
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020346:Aquaporins; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D019002:CD56 Antigen; D058851:GPI-Linked Proteins; D051272:Glucose Transporter Type 1; D006023:Glycoproteins; C451759:MUC16 protein, human; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D018396:Mucin-1; D016159:Tumor Suppressor Protein p53; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human; D053495:Osteopontin; D001194:Asbestos