title: [Research progress in molecular determinants of neuraminidase, polymerase basic protein 2 and nonstructural protein 1, related to virulence of influenza A virus--a review].
abstract: It is gradually recognized that host specificity and pathogenicity of influenza A virus could also be affected by proteins other than hemagglutinin (HA) due to its polygenic nature. In this review, detailed description was focused mainly on neuraminidase (NA), polymerase basic protein 2 (PB2) and nonstructural protein 1 (NS1), especially their molecular determinants associated with virulence and host range restriction of influenza A virus.
authors.affiliation: Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
authors.forename: Min
authors.initials: M
authors.lastname: Gu
authors.forename: Daxin
authors.initials: D
authors.lastname: Peng
authors.forename: Xiufan
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D015967:Gene Expression Regulation, Viral; D058507:Host Specificity; D006801:Humans; D009980:Influenza A virus / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D007251:Influenza, Human / Q000821:virology*; D009439:Neuraminidase / Q000235:genetics / Q000378:metabolism*; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*; D014774:Virulence
chemical_list: C085820:INS1 protein, influenza virus; C057027:PB2 protein, Influenzavirus A; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; D012324:RNA-Dependent RNA Polymerase; D009439:Neuraminidase