title: Mitochondria as potential targets in antidiabetic therapy.
abstract: A growing body of evidence suggests that mitochondrial abnormalities are involved in diabetes and associated complications. This chapter gives an overview about the effects of diabetes in mitochondrial function of several tissues including the pancreas, skeletal and cardiac muscle, liver, and brain. The realization that mitochondria are at the intersection of cells' life and death has made them a promising target for drug discovery and therapeutic interventions. Here, we also discuss literature that examined the potential protective effect of insulin, insulin-sensitizing drugs, and mitochondrial-targeted antioxidants.
authors.affiliation: Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517, Coimbra, Portugal. pismoreira@gmail.com
authors.forename: Paula I
authors.initials: PI
authors.lastname: Moreira
authors.forename: Catarina R
authors.initials: CR
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism; D020799:Pancrelipase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D007004:Hypoglycemic Agents; D007328:Insulin; D020799:Pancrelipase