title: Risk of aplastic anemia and pesticide and other chemical exposures.
abstract: Risk of aplastic anemia (AA) from occupational exposures to pesticides and industrial chemicals was evaluated in a hospital-based case control study in Thailand (541 cases of AA and 2261 controls). Exposure data were obtained via participants' self-reports and by experts' assessments and the data from these 2 exposure assessment methods were compared. There was an increased risk of AA associated with several classes of pesticides measured by either self-report or expert assessment. The strongest associations were seen in those whose exposures were identified both by self-report and by expert assessment. Comparing very high/high to no exposure, odds ratios (95% confidence intervals) were as follows: for organophosphates 3.20 (1.87-5.46), carbamates 4.75 (1.92-11.75), organochlorines 6.04 (1.31-27.84), and paraquat 2.17 (1.11-4.25). There were correlations among the pesticides because many types were used in the same job, so it was not possible to determine whether these risks were independent or because of confounding of one by another.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Indonesia, Depok, West Java, Indonesia. nurhayati-a@ui.edu
authors.forename: Nurhayati
authors.initials: N
authors.lastname: Prihartono
authors.forename: David
authors.initials: D
authors.lastname: Kriebel
authors.forename: Susan
authors.initials: S
authors.lastname: Woskie
authors.forename: Anamai
authors.initials: A
authors.lastname: Thetkhathuek
authors.forename: Nalinee
authors.initials: N
authors.lastname: Sripaung
authors.forename: Chantana
authors.initials: C
authors.lastname: Padungtod
authors.forename: David
authors.initials: D
authors.lastname: Kaufman
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced*; D002219:Carbamates / Q000009:adverse effects; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure; D010755:Organophosphates / Q000009:adverse effects; D010269:Paraquat / Q000009:adverse effects; D010564:Personnel, Hospital / Q000706:statistics & numerical data; D010575:Pesticides / Q000009:adverse effects*; D012306:Risk; D013785:Thailand; D055815:Young Adult
chemical_list: D002219:Carbamates; D006843:Hydrocarbons, Chlorinated; D010755:Organophosphates; D010575:Pesticides; D010269:Paraquat