title: Amino acids as the nitrogen-containing motifs in copper-catalyzed domino synthesis of N-heterocycles.
abstract: A copper-catalyzed domino method for synthesis of quinazolinones has been developed using readily available α-amino acids as the nitrogen-containing motifs. The domino process underwent Ullmann-type N-arylation, decarboxylation, aerobic oxidation, and intramolecular addition. This method should provide a new and useful strategy for construction of N-heterocycles.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction; D052999:Quinazolinones / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001549:Benzamides; D006571:Heterocyclic Compounds; D052999:Quinazolinones; D003300:Copper; D009584:Nitrogen