title: Treatment of a serotype-1 hepatitis C virus infection using interferon-beta in a patient with a high RNA titer who had been receiving long-term hemodialysis therapy.
abstract: A serotype-1 hepatitis C virus (HCV) infection in a 67-year-old hemodialysis patient was treated using interferon (IFN)-beta. Although the patient had a high RNA titer (5.1 log IU/mL) and had been receiving long-term hemodialysis therapy (30 years), the initial 4-week IFN-beta administration enabled a rapid virological response without any major adverse effects. However, the final outcome after 24 weeks of IFN beta treatment was classified as unchanged based on the criteria of the Conference on Intractable Hepatitis. Here, we describe our experience treating HCV infection using IFN-beta and discuss the indications for such therapy.
authors.affiliation: Sangenjaya Hospital, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Otsubo
authors.forename: Takahiko
authors.initials: T
authors.lastname: Kawata
authors.forename: Masayo
authors.initials: M
authors.lastname: Takasaki
authors.forename: Miwa
authors.initials: M
authors.lastname: Ishihara
authors.forename: Syuitsu
authors.initials: S
authors.lastname: Ueda
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Kimiko
authors.initials: K
authors.lastname: Otsubo
authors.forename: Takashi
authors.initials: T
authors.lastname: Akiba
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
authors.forename: Masanori
authors.initials: M
authors.lastname: Hirano
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000097:blood / Q000628:therapy*; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D016899:Interferon-beta / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D012367:RNA, Viral / Q000097:blood*; D006435:Renal Dialysis; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D016899:Interferon-beta