title: [A case of small-cell lung carcinoma accompanied by the syndrome of inappropriate secretion of antidiuretic hormone and Lambert-Eaton myasthenic syndrome].
abstract: Although the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and Lambert-Eaton myasthenic syndrome (LEMS) are often individually accompanied by small-cell lung carcinoma, simultaneous occurrence of the 2 syndromes is rare. A 61-year-old man was admitted to our hospital because of fatigue and myasthenia in the extremities, and small-cell lung carcinoma with pulmonary metastasis was diagnosed, together with SIADH and LEMS. These syndromes markedly ameliorated following tumor shrinkage, with 4 cycles of chemotherapy consisting of carboplatin and etoposide. On progression of the tumor thereafter, neither syndrome recurred. A literature review disclosed that these syndromes frequently resolve with tumor shrinkage.
authors.affiliation: Department of Respirology, Graduate School of Medicine, Chiba University.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Takeru
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hironori
authors.initials: H
authors.lastname: Ashinuma
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Amano
authors.forename: Fuminobu
authors.initials: F
authors.lastname: Kuroda
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tada
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takiguchi
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi
mesh_terms: D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000150:complications*; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D055752:Small Cell Lung Carcinoma / Q000150:complications*