title: T-cell-rich B-cell lymphoma (TCRBCL): limitations in fine-needle aspiration cytodiagnosis.
abstract: Exclusive reports on fine needle aspiration (FNA) cytodiagnosis of T-cell-rich B-cell lymphoma (TCRBCL) are scarce in literature. This report reflects the diagnostic difficulties associated with cytodiagnosis of this rare variant of diffuse large B-cell lymphoma. The study is based on 11 cases with age ranging from 16 to 63 years and a median of 50 years. Male to female ratio was 6:5. Ten cases presented with lymphadenopathy and one had lymphadenopathy as well as extranodal solid tumor. The initial cytodiagnosis was suggestive of TCRBCL in one case, TCRBCL/Hodgkin's lymphoma (HL) in three cases, TCRBCL/HL/anaplastic large cell lymphoma (ALCL) in two cases, TCRBCL/ALCL in one case, and TCRBCL/non-Hodgkin lymphoma (NHL) T-cell/ALCL in one case. There was also a cytologically diagnosed HL case, which on review turned out to be HL/TCRBCL. Histopathological diagnosis was HL in all these nine cases. There were two histologically diagnosed TCRBCL cases during this period, with cytodiagnoses of NHL other than TCRBCL in one and HL in the other. While highlighting the difficulties associated with the cytodiagnosis of TCRBCL, this study conveys a word of caution that adequate immunocytochemical studies should be performed before diagnosing this rare neoplasm with a varied cytomorphology.
authors.affiliation: Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait. dilip76@hotmail.com
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Das
authors.forename: Shahed K
authors.initials: SK
authors.lastname: Pathan
authors.forename: Fatma J
authors.initials: FJ
authors.lastname: Mothaffer
authors.forename: Bency
authors.initials: B
authors.lastname: John
authors.forename: Mrinmay K
authors.initials: MK
authors.lastname: Mallik
authors.forename: Zafar A
authors.initials: ZA
authors.lastname: Sheikh
authors.forename: Bahiyah E
authors.initials: BE
authors.lastname: Haji
authors.forename: Thasneem
authors.initials: T
authors.lastname: Amir
authors.forename: Issam M
authors.initials: IM
authors.lastname: Francis
mesh_terms: D000293:Adolescent; D000328:Adult; D044963:Biopsy, Fine-Needle; D003581:Cytodiagnosis / Q000379:methods*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006689:Hodgkin Disease / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000175:diagnosis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000473:pathology*; D055815:Young Adult