title: [The immunological conflict in the transfusion-related acute lung injury or TRALI].
abstract: Despite its underrated incidence, transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related morbidity and mortality worldwide. The pulmonary edema in TRALI occurs in the course of the transfusion of apheresis products or erythrocyte concentrates. Its pathogenesis is attributed to the infusion of donor antibodies that recognize leucocyte antigens in the transfused host, with subsequent sequestration of leucocytes in the pulmonary vessels. It is also associated with the passive transfer of lipids and other biological response modifiers that accumulate during the storage or processing of blood components. The innate immunity and inflammatory kinins are key components. The knowledge of its etiopathogenesis must come into play for improving prevention and diagnosis and for application of adapted care of the patient.
authors.affiliation: GREPI/AGIM CNRS FRE 3405, CHU de Grenoble, BP 217, 38043 Grenoble, France. christian.drouet@efs.sante.fr
authors.forename: C
authors.initials: C
authors.lastname: Drouet
authors.forename: K
authors.initials: K
authors.lastname: Khoy
authors.forename: D
authors.initials: D
authors.lastname: Masson
authors.forename: B
authors.initials: B
authors.lastname: Bardy
authors.forename: C
authors.initials: C
authors.lastname: Giannoli
authors.forename: V
authors.initials: V
authors.lastname: Dubois
mesh_terms: D055371:Acute Lung Injury / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D016913:Blood Component Transfusion / Q000009:adverse effects; D001793:Blood Preservation / Q000009:adverse effects; D042783:Endothelial Cells / Q000473:pathology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000097:blood; D015994:Incidence; D007518:Isoantibodies / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D008055:Lipids / Q000097:blood; D018448:Models, Immunological; D009504:Neutrophils / Q000276:immunology; D011654:Pulmonary Edema / Q000453:epidemiology / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D012306:Risk; D016176:T-Lymphocyte Subsets / Q000276:immunology; D051193:Toll-Like Receptors / Q000097:blood; D065227:Transfusion Reaction
chemical_list: D006680:HLA Antigens; D007155:Immunologic Factors; D007518:Isoantibodies; D008055:Lipids; D051193:Toll-Like Receptors