title: [The expression of integrinανβ6 and MMP-9 in gastric cancer and the correlation with clinicopathologic characteristic].
abstract: OBJECTIVE
  to investigate the expression of integrinανβ6 and MMP-9 in gastric cancer and the correlation with clinicopathologic characteristic.
  
  
  METHODS
  the expression of integrinανβ6 and MMP-9 protein was detected with immunohistochemical EnVision plus non-hiotin technique in 94 cases of gastric cancer and pericarcinoma tissues. The correlation with clinicopathologic characteristic were analyzed.
  
  
  RESULTS
  the positive expression rates of integrinανβ6 and MMP-9 protein in gastric cancer were significantly higher that tat in pericarcinoma tissues (P<0.01). The expression of integrinανβ6 were positively related to Lauren type, tumor clinical stage, differentiation degree and lymph node metascasis (N stage) (P<0.01). The expression of MMP-9 were positively related Lauren type, tumor clinical stage, differentiation degree, depth of invasion and lymph node metascasis (N stage)(P<0.01). The expression of integrinανβ6 was positively correlated with MMP-9 (r=0.672, P<0.01). Trough Cox multivariate regression analysis, Lauren type, lymph node metascasis (N stage), the expression of integrinανβ6 and MMP-9 showed significant associations with 5-year survival rate.
  
  
  CONCLUSIONS
  the overexpression of integrinανβ6 and MMP-9 in gastric cancer is closely correlated with tumor invasion and metastasis. They may be as prognostic markers and target proteins.
authors.affiliation: Department of General Surgery, Chinese Petroleum Central Hospital, Langfang 065000, China. Konglei1973@sohu.com
authors.forename: Lei
authors.initials: L
authors.lastname: Kong
authors.forename: Jing-wu
authors.initials: JW
authors.lastname: Sun
authors.forename: Cai-hong
authors.initials: CH
authors.lastname: Zhang
mesh_terms: D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D016023:Integrins / Q000096:biosynthesis*; D008207:Lymphatic Metastasis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D015996:Survival Rate
chemical_list: D000951:Antigens, Neoplasm; D016023:Integrins; C073878:integrin alphavbeta6; D020780:Matrix Metalloproteinase 9