title: Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection.
abstract: OBJECTIVE
  Characterize responses to non-nucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral treatment (ART) initiated during acute HIV infection (AHI).
  
  
  METHODS
  This was a prospective, single-arm evaluation of once-daily, co-formulated emtricitabine/tenofovir/efavirenz initiated during AHI.
  
  
  METHODS
  The primary endpoint is the proportion of responders with HIV RNA less than 200 copies/ml by week 24. We examined time to viral suppression and CD8 cell activation in relation to baseline participant characteristics. We compared time to viral suppression and viral dynamics using linear mixed-effects models between acutely infected participants and chronically infected controls.
  
  
  RESULTS
  Between January 2005 and May 2009, 61 AHI participants were enrolled. Of participants whose enrollment date allowed 24 and 48 weeks of follow-up, 47 of 51 (92%) achieved viral suppression to less than 200 copies/ml by week 24, and 35 of 41 (85.4%) to less than 50 copies/ml by week 48. The median time from ART initiation to suppression below 50 copies/ml was 93 days (range 14-337). Higher HIV RNA levels at ART initiation (P = 0.02), but not time from estimated date of infection to ART initiation (P = 0.86), were associated with longer time to viral suppression. The median baseline frequency of activated CD8+CD38+HLA-DR+ T cells was 67% (range 40-95), and was not significantly associated with longer time to viral load suppression (P = 0.15). Viremia declined to less than 50 copies/ml more rapidly in AHI than chronically infected participants. Mixed-model analysis demonstrated similar phase I HIV RNA decay rates between acute and chronically infected participants, and more rapid viral decline in acutely infected participants in phase II.
  
  
  CONCLUSIONS
  Once-daily emtricitabine/tenofovir/efavirenz initiated during AHI achieves rapid and sustained HIV suppression during this highly infectious period.
authors.affiliation: University of North Carolina at Chapel Hill, NC 27599, USA. cynthia_gay@med.unc.edu
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Gay
authors.forename: Ashley J
authors.initials: AJ
authors.lastname: Mayo
authors.forename: Chelu K
authors.initials: CK
authors.lastname: Mfalila
authors.forename: Haitao
authors.initials: H
authors.lastname: Chu
authors.forename: Anna C
authors.initials: AC
authors.lastname: Barry
authors.forename: JoAnn D
authors.initials: JD
authors.lastname: Kuruc
authors.forename: Kara S
authors.initials: KS
authors.lastname: McGee
authors.forename: Melissa
authors.initials: M
authors.lastname: Kerkau
authors.forename: Joe
authors.initials: J
authors.lastname: Sebastian
authors.forename: Susan A
authors.initials: SA
authors.lastname: Fiscus
authors.forename: David M
authors.initials: DM
authors.lastname: Margolis
authors.forename: Charles B
authors.initials: CB
authors.lastname: Hicks
authors.forename: Guido
authors.initials: G
authors.lastname: Ferrari
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Eron
mesh_terms: D000208:Acute Disease; D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D000480:Alkynes; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D048588:Benzoxazines / Q000627:therapeutic use*; D003521:Cyclopropanes; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000379:methods; D000068679:Emtricitabine; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use*; D011446:Prospective Studies; D012367:RNA, Viral / Q000187:drug effects; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D000068698:Tenofovir; D016896:Treatment Outcome; D019562:Viral Load; D055815:Young Adult
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D063065:Organophosphonates; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D003841:Deoxycytidine; D000068698:Tenofovir; D000068679:Emtricitabine; D000225:Adenine; C098320:efavirenz