title: Dosimetric comparison of RapidArc with fixed gantry intensity-modulated radiotherapy treatment for multiple liver metastases radiotherapy.
abstract: We wanted to compare the dosimetric difference and treatment efficiency of RapidArc and fixed gantry intensity-modulated radiotherapy treatment (IMRT) for multiple liver metastases. Computed tomography datasets of 10 patients were studied retrospectively. IMRT plans were generated using 5 fields and RapidArc using either 1 or 2 arcs. The dose distribution of planning target volume (PTV), organs at risk (OARs), and the normal tissue were compared. Monitor units and treatment time were scored to measure expected treatment efficiency. Both RapidArc and IMRT plans resulted in equivalent target coverage. There was no statistically significant difference for the maximum and the minimum dose of PTV. RapidArc plans achieved an improved conformity index compared with IMRT (RA1 = 1.68 ± 0.27, RA2 = 1.61 ± 0.25, IMRT = 1.80 ± 0.37). For OARs, all techniques respected planning objectives. RapidArc plans had a lower dose in V(40) of small bowel than IMRT, but were higher in mean dose of kidneys. Concerning the V(5), V(10), and V(15) of healthy tissue, RapidArc plans were higher than IMRT. However, the V(20), V(25), and V(30) of healthy tissue in RapidArc plans were lower than IMRT. Monitor units per fraction of RapidArc plans were about 40% or 46% of IMRT. Compared with IMRT plans, treatment time of RapidArc plans were reduced by 60% or 70%. All techniques respected planning objectives. RapidArc showed statistical improvements in conformity index and healthy tissue sparing with uncompromised target coverage. This, in combination with fewer monitor units and short delivery time, can lead to clinically significant advances for the treatment of multiple liver metastases.
authors.affiliation: School of Information Science and Engineering of Shandong University, Shandong Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yin
authors.forename: Changsheng
authors.initials: C
authors.lastname: Ma
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.forename: Jinhu
authors.initials: J
authors.lastname: Chen
authors.forename: Yidong
authors.initials: Y
authors.lastname: Ma
authors.forename: Tonghai
authors.initials: T
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
mesh_terms: D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary; D011874:Radiometry; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000295:instrumentation / Q000379:methods*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome