title: Immunotherapy with pluripotent stem cell-derived dendritic cells.
abstract: In vivo transfer of dendritic cells (DC) has proven efficient in the priming of T cells and is regarded as a powerful means of providing anti-cancer immunotherapy. Clinical trials of anti-cancer therapy with DC pulsed with peptide antigens have been carried out in many institutions, although dramatic therapeutic effect has not been observed in most of the trials. Negative regulation of the immune response by DC might be applicable to treatment of autoimmune diseases and transplantation medicine. Currently, the DC used for anti-cancer vaccine therapy are generated from the peripheral blood monocytes of the patients. However, there is a limitation in the number of available monocytes and the potential of monocytes to differentiate into DC varies depending on the individual blood donors. To resolve the issue of the cell source for DC therapy, several groups have developed methods to generate DC from pluripotent stem cells. This review introduces methods to generate functional DC from pluripotent stem cells of mouse and human.
authors.affiliation: Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. senjusat@gpo.kumamoto-u.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Senju
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Matsunaga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukushima
authors.forename: Shinya
authors.initials: S
authors.lastname: Hirata
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Motomura
authors.forename: Daiki
authors.initials: D
authors.lastname: Fukuma
authors.forename: Hidetake
authors.initials: H
authors.lastname: Matsuyoshi
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nishimura
mesh_terms: D000818:Animals; D015551:Autoimmunity; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation*; D053595:Embryonic Stem Cells / Q000378:metabolism; D006801:Humans; D056747:Immunomodulation; D007165:Immunosuppression Therapy; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology