title: Primary high-grade B-cell lymphoma of the breast with concurrent IGH-BCL2 and MYC-IGL translocations in an adolescent patient.
abstract: BCL2 and MYC are oncogenes often deregulated in lymphomas. Concurrent IGH-BCL2 and MYC translocations result in a highly aggressive behavior of these tumors. Both primary breast lymphoma and lymphoma with concurrent BCL2-IGH and MYC translocations are rare and are primarily seen in adult patients. As a result of limited clinician experience and the condition's rarity, it poses a great challenge to pediatric pathologists and oncologists in terms of making an accurate diagnosis and choosing better treatment regimens. In this article, we report a case of an adolescent patient who presented with high-grade breast lymphoma with concurrent BCL2-IGH and MYC-IGL translocations, and we review the clinical, pathological, and genetic features; management strategies; and outcomes associated with this unusual neoplasm.
authors.affiliation: Department of Pathology, The Children's Hospital, Aurora, CO, USA. liang.xiayuan@tchden.org
authors.forename: Xiayuan
authors.initials: X
authors.lastname: Liang
authors.forename: Ashley
authors.initials: A
authors.lastname: Jones
authors.forename: Roger H
authors.initials: RH
authors.lastname: Giller
authors.forename: Karen
authors.initials: K
authors.lastname: Swisshelm
authors.forename: Loris
authors.initials: L
authors.lastname: McGavran
authors.forename: Lynne
authors.initials: L
authors.lastname: Meltesen
authors.forename: Billie
authors.initials: B
authors.lastname: Carstens
authors.forename: Amy N
authors.initials: AN
authors.lastname: McGranahan
authors.forename: Edythe A
authors.initials: EA
authors.lastname: Albano
mesh_terms: D059786:Abnormal Karyotype; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D050438:Genes, Immunoglobulin Heavy Chain / Q000235:genetics*; D050439:Genes, Immunoglobulin Light Chain / Q000235:genetics*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D014178:Translocation, Genetic; D055815:Young Adult
chemical_list: D004273:DNA, Neoplasm; C489427:MYC protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc