title: Substrate effects on interactions of lipid bilayer assemblies with bound nanoparticles.
abstract: Understanding the interactions of nanoparticles with lipid membranes is crucial in establishing the mechanisms that govern assembly of membrane-based nanocomposites, nanotoxicology, and biomimetic inspired self-assembly. In this study, we explore binding of charged nanoparticles to lipid bilayers, both as liposomes and substrate supported assemblies. We find that the presence of a solid-support, regardless of curvature, eliminates the ability of zwitterionic fluid phase lipids to bind charged nanoparticles.
authors.affiliation: Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM, USA. mgoertz@sandia.gov
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Goertz
authors.forename: Nikita
authors.initials: N
authors.lastname: Goyal
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Bunker
authors.forename: Gabriel A
authors.initials: GA
authors.lastname: Montaño
mesh_terms: D001665:Binding Sites; D032701:Biomimetics / Q000379:methods; D008051:Lipid Bilayers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D008051:Lipid Bilayers