title: Frequency of HCV infection in renal cell carcinoma patients.
abstract: Chronic infections with hepatitis C virus (HCV) are frequently pronounced in the etiology of malignancies especially in hepatocellular carcinoma. The association between HCV and risk of renal cell carcinoma (RCC) development has been stated recently. The authors retrospectively evaluated hepatitis serology for HCV and HBV in patients who had RCC diagnosis between 2005 and 2010 in six oncology centers. Control group was also included from the three different published studies that hepatitis serology studied in healthy people that has been living in the same geographic regions. Histologically confirmed 903 RCC cases and 5,267 healthy subjects were included the study. Median age at diagnosis of RCC was 58 (range: 26-89). There was no increase in HCV positivity in RCC patients compared to healthy control group (1.7 vs. 1.5%; P = 0.77). Frequency of HBsAg positivity was 4.4 and 4.1% in RCC and control groups, respectively (P = 0.65). There is no increase in frequency of HCV and HBsAg positivity in RCC patients. HCV positivity in RCC patients were not different from the healthy people.
authors.affiliation: Department of Medical Oncology, Dr Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Burçin
authors.initials: B
authors.lastname: Budakoğlu
authors.forename: Sercan
authors.initials: S
authors.lastname: Aksoy
authors.forename: Çağatay
authors.initials: Ç
authors.lastname: Arslan
authors.forename: Ümmügül
authors.initials: Ü
authors.lastname: Üyetürk
authors.forename: Nalan Akgül
authors.initials: NA
authors.lastname: Babacan
authors.forename: Muhammet Fuat
authors.initials: MF
authors.lastname: Özcan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yıldız
authors.forename: Başak Bala
authors.initials: BB
authors.lastname: Öven
authors.forename: Nuriye Yıldırım
authors.initials: NY
authors.lastname: Özdemir
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Dizdar
authors.forename: Süleyman
authors.initials: S
authors.lastname: Büyükberber
authors.forename: M Bülent
authors.initials: MB
authors.lastname: Akıncı
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Türker
authors.forename: Berna
authors.initials: B
authors.lastname: Öksüzoğlu
authors.forename: Kadri
authors.initials: K
authors.lastname: Altundag
authors.forename: Nurullah
authors.initials: N
authors.lastname: Zengin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors