title: Florid, papillary endosalpingiosis of the axillary lymph nodes.
abstract: A 55-year-old woman underwent radical mastectomy and axillary node dissection because of an invasive ductal carcinoma with neuroendocrine features. Histologically, all 22 sampled lymph nodes had widespread cystic inclusions lined by a regular, serous-type epithelium positive for cytokeratin-7, WT-1, CA125, and estrogen receptors. Papillary projections were found in the lumen of some cysts. The lesions were consistent with florid, papillary endosalpingiosis (FPE), a hitherto unreported condition in a supradiaphragmatic location. Metastases from papillary carcinomas of ovary, breast, or thyroid were excluded considering the lesion's immunophenotype (negative for mammaglobin and TTF-1) and the absence of both atypical features and a concurrent abdominal serous tumor. In only one node, lesions co-existed with a metastasis of breast carcinoma. Supradiaphragmatic FPE represents a pitfall in the differential diagnosis of metastases, especially in sentinel nodes, since it may increase their size and reveal an unusual ultrasonographic image. Clinicopathologic findings and a focused immunohistochemical study led to the correct diagnosis of this benign lesion.
authors.affiliation: Department of Pathology, University of Medicine of Targu Mures, Str. Gh. Marinescu Nr. 50, Targu Mures, Romania. stolnicu@gmx.net
authors.forename: Simona
authors.initials: S
authors.lastname: Stolnicu
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Preda
authors.forename: Szabo
authors.initials: S
authors.lastname: Kinga
authors.forename: Cristina
authors.initials: C
authors.lastname: Marian
authors.forename: Romeo
authors.initials: R
authors.lastname: Nicolau
authors.forename: Sorin
authors.initials: S
authors.lastname: Andrei
authors.forename: Alina
authors.initials: A
authors.lastname: Nicolae
authors.forename: Francisco F
authors.initials: FF
authors.lastname: Nogales
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008206:Lymphatic Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D021701:Sentinel Lymph Node Biopsy