title: Syntheses and biological activities of 1,4-iminoalditol derivatives as alpha-L-fucosidase inhibitors.
abstract: A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of alpha-L-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.
authors.affiliation: Dept. Organic Chemistry, Faculty of Chemistry, University of Seville, P.O. Box 1203, E-41071 Seville, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Moreno-Clavijo
authors.forename: Ana T
authors.initials: AT
authors.lastname: Carmona
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Moreno-Vargas
authors.forename: Lidia
authors.initials: L
authors.lastname: Molina
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Robina
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D050113:Imino Furanoses / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D005644:alpha-L-Fucosidase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D050113:Imino Furanoses; D005644:alpha-L-Fucosidase