title: Pharmacogenomics of serious adverse drug reactions in pediatric oncology.
abstract: Adverse drug reactions (ADRs) rank as one of the top ten leading causes of death and illness in the developed world. In cancer therapy, more patients are surviving cancer than ever before, but 40% of cancer survivors suffer life-threatening or permanently disabling severe ADRs and are left with long-term sequelae. ADRs are often more frequent and more severe in children, and the consequences for children who experience a severe ADR can be catastrophic. Pharmacogenomics has the potential to improve the safety of these drugs. This review highlights severe ADRs that can occur in cancer therapy that are more frequent and more severe in children, and the pharmacogenomics research that aims to understand, predict, and ultimately prevent these severe reactions.
authors.affiliation: Department of Medical Genetics, University of British Columbia (UBC), Centre for Molecular Medicine and Therapeutics,
authors.forename: Colin J D
authors.initials: CJ
authors.lastname: Ross
authors.forename: Henk
authors.initials: H
authors.lastname: Visscher
authors.forename: S Rod
authors.initials: SR
authors.lastname: Rassekh
authors.forename: Lucila I
authors.initials: LI
authors.lastname: Castro-Pastrana
authors.forename: Evan
authors.initials: E
authors.lastname: Shereck
authors.forename: Bruce
authors.initials: B
authors.lastname: Carleton
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hayden
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002945:Cisplatin / Q000009:adverse effects; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects; D009369:Neoplasms / Q000188:drug therapy*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D010597:Pharmacogenetics; D014750:Vincristine / Q000009:adverse effects; D014859:Warfarin / Q000009:adverse effects
chemical_list: D018943:Anthracyclines; D000970:Antineoplastic Agents; D014750:Vincristine; D014859:Warfarin; D002945:Cisplatin; D008727:Methotrexate