title: Synthesis of new 1-phenyl-6H-pyrido[4,3-b]carbazole derivatives with potential cytostatic activity.
abstract: A number of new 1-substituted-6H-pyrido[4,3-b]carbazole derivatives have been synthesized. Nine of the newly obtained compounds were subjected to preliminary in vitro cytostatic activity screening against murine leukemia (L1210), human lung cancer (A549) and human colon cancer (HT29) cell lines. One particular compound 6f exhibited over 20 times better activity against L1210 tumor cell line than the reference ellipticine.
authors.affiliation: Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, Grodzka 9 St., 50-137 Wrocław, Poland. diana@chorg.am.wroc.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Tylińska
authors.forename: Ryszard
authors.initials: R
authors.lastname: Jasztold-Howorko
authors.forename: Henryk
authors.initials: H
authors.lastname: Mastalarz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Szczaurska-Nowak
authors.forename: Paulina
authors.initials: P
authors.lastname: Materek
authors.forename: Joanna
authors.initials: J
authors.lastname: Wietrzyk
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004611:Ellipticines / Q000138:chemical synthesis* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004611:Ellipticines; C034192:ellipticine