title: Combination of platelet-rich plasma with degradable bioactive borate glass for segmental bone defect repair.
abstract: Porous scaffold biomaterials may offer a clinical alternative to bone grafts; however, scaffolds alone are typically insufficient to heal large bone defects. Numerous studies have demonstrated that osteoinductive growth factor significantly improves bone repair. In this study, a strategy combining degradable bioactive borate glass (BG) scaffolds with platelet-rich plasma (PRP) was tested. The bone defect was filled with BG alone, BG combined with autologous PRP or left empty. Bone formation was analyzed at 4, 8 and 12 weeks using both histology and radiology. The PRP treated group yielded better bone formation than the pure BG scaffold as determined by both histology and microcomputer tomography after 12 weeks. In conclusion, PRP improved bone healing in a diaphyseal rabbit model on BG. The combination of PRP and BG may be an effective approach to repair critical defects.
authors.affiliation: Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao-tong University, School of Medicine, 600 Yishan Road, Shanghai 200233, PR China.
authors.forename: Ya-Dong
authors.initials: YD
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D018786:Bone Substitutes / Q000627:therapeutic use*; D001881:Borates; D005898:Glass; D008297:Male; D010012:Osteogenesis / Q000502:physiology*; D053657:Platelet-Rich Plasma; D011817:Rabbits; D054457:Tissue Scaffolds; D014945:Wound Healing / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D001881:Borates