title: The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese.
abstract: Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH patients and 194 healthy controls from Jiangsu area (south of China). Individuals all carried the GG wild genotype, no GA or AA genotypes were found. Our results suggest that IL-6-597G/A polymorphism is extremely rare and unlikely to be contributing significantly to disease susceptibility in southern Han Chinese.
authors.affiliation: Department of Cardiology, Ningxia People's Hospital, 148 West Huaiyuan Road, Yinchuan 750021, People's Republic of China.
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Gao
authors.forename: Min
authors.initials: M
authors.lastname: Pan
authors.forename: Chu
authors.initials: C
authors.lastname: Chen
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Ge
authors.forename: Min-Hui
authors.initials: MH
authors.lastname: Jiang
authors.forename: Hong
authors.initials: H
authors.lastname: Luan
authors.forename: Jin-Guo
authors.initials: JG
authors.lastname: Zheng
authors.forename: Xin-Tao
authors.initials: XT
authors.lastname: Deng
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Pan
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zhu
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6