title: Synthesis of cis-1,2-dihaloalkenes featuring palladium-catalyzed coupling of haloalkynes and α,β-unsaturated carbonyls.
abstract: A highly regio- and stereoselective method for the synthesis of cis-1,2-dihaloalkenes through Pd-catalyzed coupling of haloalkynes and α,β-unsaturated carbonyls has been reported. Excellent stereoselectivities (Z/E up to >98:2) were observed in most cases. This method was subsequently applied to synthesize the functionalized conjugated enyne via the mono-Sonogashira coupling reaction of cis-1-chloro-2-iodoalkene.
authors.affiliation: Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China.
authors.forename: Dongxu
authors.initials: D
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Cao
authors.forename: Zheliang
authors.initials: Z
authors.lastname: Yuan
authors.forename: Haiting
authors.initials: H
authors.lastname: Cai
authors.forename: Renwei
authors.initials: R
authors.lastname: Zheng
authors.forename: Lichun
authors.initials: L
authors.lastname: Kong
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000447:Aldehydes; D000475:Alkenes; D000480:Alkynes; D006219:Halogens; D007659:Ketones; D010165:Palladium