title: Hesperetin inhibits the maturation and function of monocyte-derived dendritic cells from patients with asthma.
abstract: Dendritic cells (DCs) are crucial regulators of allergic diseases. Hesperetin, an important bioactive compound in Chinese traditional medicine, has antioxidant and anti-allergic properties. In this study, we examined whether hesperetin influences surface molecule expression, cytokine production, the capacity to induce T cell proliferation, and the underlying signaling pathway in monocyte-derived DCs from patients with allergic asthma. The results show that hesperetin significantly suppressed Der p 1-induced HLA-DR, CD86 and CD83 expression in DCs. However, the secretion of IL-10 was not affected. Hesperetin-treated DCs exhibited a reduced ability to stimulate autologous CD4+ T cells, accompanied by less Th2 polarization. In addition, the Der p 1-induced phosphorylation of IκBα and the translocation of NF-κB p65 were inhibited in the presence of hesperetin. These novel findings provide insight into the immunopharmacological role of hesperetin in DC-based allergic diseases.
authors.affiliation: Department of Respiratory Medicine, The 454th Hospital of Chinese PLA, Nanjing 210002, P.R. China.
authors.forename: Xiaouan
authors.initials: X
authors.lastname: Gu
authors.forename: Linfu
authors.initials: L
authors.lastname: Zhou
authors.forename: Qiang
authors.initials: Q
authors.lastname: Du
authors.forename: Desheng
authors.initials: D
authors.lastname: Jiang
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Yang
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Ji
authors.forename: Kaisheng
authors.initials: K
authors.lastname: Yin