title: Glucocorticoids in the treatment of neonatal meconium aspiration syndrome.
abstract: Meconium aspiration syndrome is a serious neonatal disease with complex pathophysiology. With respect to the contribution of meconium-induced lung edema, inflammation and vasoconstriction on the course of the disease, glucocorticoids are increasingly used in the treatment of MAS despite the fact that principal questions on the choice of GCs derivative, mode of delivery and dosing have not been answered yet. To bring a complex insight into the topic, this article reviews the pathomechanisms of MAS, mechanisms of action of GCs, as well as the advantages and disadvantages of GCs administration in experimental models and newborns with MAS.
authors.affiliation: Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Mala Hora 4, SK-03601 Martin, Slovakia. mokra@jfmed.uniba.sk
authors.forename: Daniela
authors.initials: D
authors.lastname: Mokra
authors.forename: Juraj
authors.initials: J
authors.lastname: Mokry
mesh_terms: D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008471:Meconium Aspiration Syndrome / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids