title: Isolated prenatal choroid plexus cysts do not affect child development.
abstract: OBJECTIVE
  To examine the effect of isolated prenatal choroid plexus cysts (CPCs) on child cognitive, behavioral, motor, and autonomic development at 18 months of age.
  
  
  METHODS
  A prospective design was implemented to identify CPC cases and controls in mid-pregnancy. Cases (n = 25) and controls (n = 45) participated in a follow-up visit when children were 18 months of age. Child mental and motor development was assessed using standard developmental assessments, socioemotional and behavioral functioning during testing was rated by examiners, and accelerometers provided measures of motor activity and energy expenditure. Cardiac patterns were collected using a three-lead electrocardiogram (ECG) and quantified as indicators of autonomic control of the heart, including vagal tone.
  
  
  RESULTS
  No significant differences were found in any outcome measure between children with prenatal CPC detection and those without.
  
  
  CONCLUSIONS
  Findings should provide reassurance to practitioners and parents that isolated CPCs in fetuses with normal karyotypes do not affect child development after birth.
authors.affiliation: Department of Population and Family Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. jdipietr@jhsph.edu
authors.forename: Janet A
authors.initials: JA
authors.lastname: DiPietro
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Cristofalo
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Voegtline
authors.forename: Jude
authors.initials: J
authors.lastname: Crino
mesh_terms: D000328:Adult; D001288:Attention; D001341:Autonomic Nervous System / Q000503:physiopathology; D001927:Brain Diseases / Q000151:congenital* / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D016022:Case-Control Studies; D020863:Central Nervous System Cysts / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D002657:Child Development; D002831:Choroid Plexus / Q000503:physiopathology*; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009043:Motor Activity; D011247:Pregnancy; D011446:Prospective Studies; D011597:Psychomotor Performance; D016216:Ultrasonography, Prenatal