title: Bioactive properties of Tynanthus panurensis (Bureau) Sanwith bark extract, the Amazonian "clavo huasca".
abstract: Tynanthus panurensis (Bureau) Sanwith (Bignoniaceae) is a liana vine used in traditional Amazonian medicine as a tonic and energizer as well as a treatment for rheumatism. These traditional indications prompted this study of the antioxidant and anti-inflammatory activities of T. panurensis bark extract (ETP). Phytochemical analysis of ETP showed the presence of saponins and a high concentration of phenols and flavonoids. A battery of in vitro tests revealed that the extract has free radical-scavenging antioxidant properties and reduces microsomal lipid peroxidation, uric acid synthesis, and tumor necrosis factor-α production. The anti-inflammatory properties of ETP were further confirmed in vivo in a rat carrageenan edema model, in which the extract exhibited a potent activity. These results support the idea that T. panurensis bark extract could be beneficial for treating inflammation and are in agreement with one of the main traditional uses of this plant.
authors.affiliation: Department of Pharmaceutical and Food Sciences, Universidad CEU-San Pablo, Madrid, Spain.
authors.forename: Lidia
authors.initials: L
authors.lastname: Morales
authors.forename: Nuria
authors.initials: N
authors.lastname: Acero
authors.forename: Antonio
authors.initials: A
authors.lastname: Galán
authors.forename: Carmen
authors.initials: C
authors.lastname: Perez-García
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Alguacil
authors.forename: Dolores
authors.initials: D
authors.lastname: Muñoz-Mingarro
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D029402:Bignoniaceae / Q000737:chemistry*; D004487:Edema / Q000276:immunology / Q000517:prevention & control; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018922:HL-60 Cells; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008519:Medicine, Traditional; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013020:South America; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D014969:Xanthine Oxidase