title: Crohn's disease and small bowel adenocarcinoma: a population-based case-control study.
abstract: BACKGROUND
  Although Crohn's disease (CD) is thought to predispose to adenocarcinomas of the small bowel, the association has not been well studied in an older population.
  
  
  OBJECTIVE
  The objective of our study was to evaluate the association of CD with small bowel cancer in a population-based case-control study.
  
  
  METHODS
  All cases of small bowel cancer in persons 67 and older in the Surveillance, Epidemiology and End Results catchment area and in the Medicare claims data base were compared with cancer-free controls residing in the same geographic area. We used multivariable logistic regression models adjusted for demographic and other factors.
  
  
  RESULTS
  We identified 923 cases of small bowel cancer and 142,273 controls. Although we found a strong association between CD and small bowel cancer (OR = 12.07; 95% CI: 6.07-20.80; P < 0.001), the prevalence of CD in patients with small bowel cancer was low (1.6%).
  
  
  CONCLUSIONS
  Although CD is a significant risk factor for small bowel cancers among individuals older than 67, the absolute risk is small.
  
  
  CONCLUSIONS
  Older individuals with CD can be reassured that although there is an association between CD and small bowel cancer, the absolute risk remains small.
authors.affiliation: Section of Gastroenterology, Department of Medicine, VA Medical Center and University of Minnesota, Minneapolis, Minnesota 55417, USA. shaukat@umn.edu
authors.forename: Aasma
authors.initials: A
authors.lastname: Shaukat
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Virnig
authors.forename: David
authors.initials: D
authors.lastname: Howard
authors.forename: Shanthi V
authors.initials: SV
authors.lastname: Sitaraman
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Liff
authors.forename: Frank A
authors.initials: FA
authors.lastname: Lederle
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology*; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003424:Crohn Disease / Q000150:complications* / Q000453:epidemiology; D004379:Duodenal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D007421:Intestine, Small / Q000473:pathology*; D007580:Jejunal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D011379:Prognosis; D012307:Risk Factors; D018426:SEER Program