title: [Severe hypertriglyceridemia and macrophage activation syndrome: a case report].
abstract: We report the case of a 36-year-old patient admitted for Macrophage Activation Syndrome (MAS), revealed by inflammatory dermo-hypodermal lesions, tumor syndrome, pancytopenia, biological cholestasis, increased lactate dehydrogenase rates and hemophagocytosis in skin biopsies. The patient also exhibited an exponential increase in triglycerides serum levels that reached 22 g/L. The patient died after multiple organ failure. This case illustrates the value of the hypertriglyceridemia in the diagnosis and monitoring of hemophagocytic syndrome but also highlights the difficulty in understanding its pathophysiology especially with several elements that contribute to its aggravation during the evolution of this syndrome.
authors.affiliation: Unité de biochimie clinique, Laboratoire d'analyses médicales, Centre hospitalier universitaire Mohammed VI ; Faculté de médecine et pharmacie, Université cadi Ayyad, Marrakech, Maroc. taliali1@yahoo.fr
authors.forename: Abdelali
authors.initials: A
authors.lastname: Tali
authors.forename: Amal
authors.initials: A
authors.lastname: Addebbous
authors.forename: Meryem
authors.initials: M
authors.lastname: Rachid
authors.forename: Laila
authors.initials: L
authors.lastname: Zougaghi
authors.forename: Nadia
authors.initials: N
authors.lastname: Akhdari
authors.forename: Amal
authors.initials: A
authors.lastname: Said
authors.forename: Laila
authors.initials: L
authors.lastname: Chabaa
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000175:diagnosis*; D055501:Macrophage Activation Syndrome / Q000175:diagnosis*; D009102:Multiple Organ Failure / Q000209:etiology; D012720:Severity of Illness Index