title: Promises of apoptosis-inducing peptides in cancer therapeutics.
abstract: Until recently, most research efforts aimed at developing anti-cancer tools were focusing on small molecules. Alternative compounds are now being increasingly assessed for their potential anti-cancer properties, including peptides and their derivatives. One earlier limitation to the use of peptides was their limited capacity to cross membranes but this limitation was alleviated with the characterization of cell-permeable sequences. Additionally, means are designed to target peptides to their malignant targets. Most anti-cancer peptidic compounds induce apoptosis of tumor cells by modulating the activity of Bcl-2 family members that control the release of death factors from the mitochondria or by inhibiting negative regulators of caspases, the proteases that mediate the apoptotic response in cells. Some of these peptides have been shown to inhibit the growth of tumors in mouse models. Hopefully, pro-apoptotic anti-tumor peptides will soon be tested for their efficacy in patients with cancers.
authors.affiliation: Department of Physiology, Lausanne University, 1005 Lausanne, Switzerland.
authors.forename: David
authors.initials: D
authors.lastname: Barras
authors.forename: Christian
authors.initials: C
authors.lastname: Widmann
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D015195:Drug Design; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D010455:Peptides / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D010455:Peptides