title: [Antidepressant effect and mechanism of action of a novel aminouracil derivative].
abstract: The psychotropic activity of a series of new aminouracil derivatives was studied on the widely applied models of pharmacological screening in rats. The most expressed antidepressant effect at the stage of primary pharmacological screening was been revealed for compound PIR-03-52 in a dose of 10 mg/kg. A profound study of the antidepressant activity on models of pathological states, PIR-03-52 exhibited a pronounced antidepressant effect that was comparable with that of a reference drug (imipramine). The given effect is related to the positive influence of PIR-03-52 on the serotoninergic and dopaminergic systems.
authors.forename: D G
authors.initials: DG
authors.lastname: Kovalev
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013315:Stress, Psychological / Q000150:complications / Q000188:drug therapy; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C558415:1-benzoylmethyl-5-(N-pyrrolidino)uracyl; D000928:Antidepressive Agents; D011725:Pyridines; D014498:Uracil; C011166:5-aminouracil