title: Effects of carboxymethyl chitosan on the blood system of rats.
abstract: Carboxymethyl chitosan (CM-chitosan), a derivative of chitosan, was extensively studied in the biomedical materials field for its beneficial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CM-chitosan in the blood system are lacking. In this study CM-chitosan was implanted into the abdominal cavity of rats to determine blood indexes at different times and to evaluate the effects of CM-chitosan on the blood system of rats. Coagulation function was reflected by thrombin time (TT), prothrombin time (PT), activated partial thromboplatin time (APTT), fibrinogen (FIB) and platelet factor 4 (PF4) indexes; anti-coagulation performance was assessed by the index of antithrombinIII (ATIII); fibrinolytic function was reflected by plasminogen (PLG) and fibrin degradation product (FDP) indexes; and blood viscosity (BV) and plasma viscosity (PV) indexes reflected hemorheology. Results showed that CM-chitosan has no significant effects on the blood system of rats, and provides experimental basis for CM-chitosan to be applied in the field of biomedical materials.
authors.affiliation: College of Marine Life Sciences, Ocean University of China, Qingdao 266003, People's Republic of China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Fu
authors.forename: Baoqin
authors.initials: B
authors.lastname: Han
authors.forename: Wen
authors.initials: W
authors.lastname: Dong
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yang
authors.forename: You
authors.initials: Y
authors.lastname: Lv
authors.forename: Wanshun
authors.initials: W
authors.lastname: Liu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects*; D048271:Chitosan / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D011517:Prothrombin Time; D051381:Rats; D011919:Rats, Inbred Strains; D013918:Thrombin Time
chemical_list: D001672:Biocompatible Materials; C514968:carboxymethyl-chitosan; D048271:Chitosan