title: Metabolic effects of the ingestion of different fructose sources in rats.
abstract: BACKGROUND
  Fructose is a simple carbohydrate that should be ingested in a restricted manner. However, current data suggest increased daily consumption of fructose which may lead to an increased incidence of diseases such as obesity, diabetes and co-morbidities associated with excess weight. Thus, the objective of the present study was to assess the effect of the ingestion of different fructose sources on weight gain, glycemia and serum triglyceride levels in rats.
  
  
  METHODS
  The study was conducted on male Wistar rats divided into 5 groups according to the source and concentration of fructuse (ingested AD LIBITUM in liquid form).
  
  
  RESULTS
  Drink intake was increased and chow consumption was reduced in all groups compared to control ( P<0.05). The animals of the groups receiving 10 and 20% fructose solutions showed increased triglyceride levels and the 20% group also showed weight gain. The exaggerate consumption of fructose promotes a reduced consumption of chow, an increase in serum triglyceride levels, and weight gain in some animals.
authors.affiliation: Postgraduation in Medical Sciences, Department of Medicine, Faculty of Medicine of Ribeirão Preto-USP. clarissameirelles@usp.br
authors.forename: C J C S
authors.initials: CJ
authors.lastname: Meirelles
authors.forename: L A
authors.initials: LA
authors.lastname: Oliveira
authors.forename: A A
authors.initials: AA
authors.lastname: Jordão
authors.forename: A M
authors.initials: AM
authors.lastname: Navarro
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D003920:Diabetes Mellitus / Q000097:blood / Q000209:etiology; D005632:Fructose / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D009765:Obesity / Q000097:blood / Q000209:etiology; D051381:Rats; D017208:Rats, Wistar; D013549:Sweetening Agents / Q000009:adverse effects / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood*
chemical_list: D013549:Sweetening Agents; D014280:Triglycerides; D005632:Fructose