title: Hsa-miR-196a2 Rs11614913 polymorphism contributes to cancer susceptibility: evidence from 15 case-control studies.
abstract: BACKGROUND
  MicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results.
  
  
  RESULTS
  We conducted a meta-analysis of 15 studies that included 9,341 cancer cases and 10,569 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR=1.18, 95% CI=1.03-1.34, P<0.001 for heterogeneity test). In the stratified analyses, we observed that the CC genotype might modulate breast cancer risk (OR=1.11, 95%CI=1.01-1.23, Pheterogeneity=0.210) and lung cancer risk (OR=1.25, 95%CI=1.06-1.46, Pheterogeneity=0.958), comparing with the TC/TT genotype. Moreover, a significantly increased risk was found among Asian populations in a dominant model (TC/CC versus TT, OR=1.24, 95% CI=1.07-1.43, Pheterogeneity=0.006).
  
  
  CONCLUSIONS
  These findings supported that hsa-miR-196a2 rs11614913 polymorphism may contribute to the susceptibility of cancers.
authors.affiliation: Jiangsu Key Lab of Cancer Biomarkers, Prevention & Treatment, Cancer Center, Department of Molecular & Genetic Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chu
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Danni
authors.initials: D
authors.lastname: Shi
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Na
authors.initials: N
authors.lastname: Tong
authors.forename: Xinying
authors.initials: X
authors.lastname: Huo
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Dewei
authors.initials: D
authors.lastname: Luo
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C542543:MIRN196 microRNA, human; D035683:MicroRNAs