title: A mathematical model of medial collateral ligament repair: migration, fibroblast proliferation and collagen formation.
abstract: The partial rupture of ligament fibres leads to an injury known as grade 2 sprain. Wound healing after injury consists of four general stages: swelling, release of platelet-derived growth factor (PDGF), fibroblast migration and proliferation and collagen production. The aim of this paper is to present a mathematical model based on reaction-diffusion equations for describing the repair of the medial collateral ligament when it has suffered a grade 2 sprain. We have used the finite element method to solve the equations of this. The results have simulated the tissue swelling at the time of injury, predicted PDGF influence, the concentration of fibroblasts migrating towards the place of injury and reproduced the random orientation of immature collagen fibres. These results agree with experimental data reported by other authors. The model describes wound healing during the 9 days following such injury.
authors.affiliation: Group of Mathematical Modeling and Numerical Methods, GNUM-UN, National University of Colombia, Bogotá, Colombia.
authors.forename: D A
authors.initials: DA
authors.lastname: Garzón-Alvarado
authors.forename: R P
authors.initials: RP
authors.lastname: Cárdenas Sandoval
authors.forename: J C
authors.initials: JC
authors.lastname: Vanegas Acosta
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D008022:Ligaments / Q000166:cytology* / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000378:metabolism
chemical_list: D010982:Platelet-Derived Growth Factor; D003094:Collagen