title: The effect of sodium metabisulfite on visual evoked potentials in rats with hypercholesterolemia.
abstract: This study aimed to investigate the effects of hypercholesterolemia on visual evoked potentials (VEPs) and sulfite additional effects. Rats were assigned as follows: control (C), sulfite (S), hypercholesterolemia (H), vitamin E (E), sulfite + vitamin E (SE), hypercholesterolemia + sulfite (HS), hypercholesterolemia + vitamin E (HE), and hypercholesterolemia + sulfite + vitamin E (HSE). Hypercholesterolemic diet led significant increase in plasma cholesterol levels of rats. Brain thiobarbituric acid reactive substances (TBARS) levels were significantly increased in S, E, SE, HE and HSE groups compared with C. TBARS levels were increased in HE and HSE groups as compared to HS group. Nitrite levels were decreased in S, SE, H, HS and HSE groups compared with C. Nitrite level was notably increased in the HE group compared with H group. Sulfite exposure prolonged N1 and P3 latencies of VEP in group S compared with C. Prolonged VEP latencies by sulfite were significantly decreased by vitamin E in SE group. Cholesterol rich diet increased VEP latencies in comparison with control latencies. Sulfite gave rise to an additional increase in P3 latency in HS group compared with H group. Vitamin E-treated animals had notably shortened latencies of VEP components in HE and HSE groups according to the H and HS groups, respectively.
authors.affiliation: Department of Physiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Feyza
authors.initials: F
authors.lastname: Savcioglu
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ozsoy
authors.forename: Gulay
authors.initials: G
authors.lastname: Hacioglu
authors.forename: Vural
authors.initials: V
authors.lastname: Kucukatay
authors.forename: Piraye
authors.initials: P
authors.lastname: Yargicoglu
authors.forename: Aysel
authors.initials: A
authors.lastname: Agar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000009:adverse effects; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D006937:Hypercholesterolemia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D016877:Oxidants / Q000037:antagonists & inhibitors / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D010775:Photic Stimulation; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D013447:Sulfites / Q000037:antagonists & inhibitors / Q000633:toxicity*; D014795:Visual Pathways / Q000187:drug effects* / Q000503:physiopathology; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D009573:Nitrites; D016877:Oxidants; D013447:Sulfites; D014810:Vitamin E; C005200:sodium metabisulfite; D002784:Cholesterol