title: [Anxiosedative properties of heteryl(aryl)-containing hexahydrobenzofuranon derivatives].
abstract: The anxiosedative properties of 2-hydroxyimino-3-indolylyl(aryl)-4-oxo-2,3,4,5,6,7-hexahydrobenzofuranon derivatives have been studied using the open-field test, elevated plus-maze test, and conflict drinking procedure as developed by Vogel. It is established that all derivatives with both indole and aryl substituents produce a sedative effect. However, an anxiolytic effect is determined by the presence of indole substituent in the third position of the hexahydrobenzofuran molecule.
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
authors.forename: V V
authors.initials: VV
authors.lastname: Bagmetova
authors.forename: O V
authors.initials: OV
authors.lastname: Ivanova
authors.forename: V M
authors.initials: VM
authors.lastname: Berestovitskaia
authors.forename: O S
authors.initials: OS
authors.lastname: Vasil'eva
authors.forename: E S
authors.initials: ES
authors.lastname: Ostrogliadov
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D003220:Conflict, Psychological; D004327:Drinking Behavior / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D014151:Anti-Anxiety Agents; D001572:Benzofurans; D006993:Hypnotics and Sedatives