title: Two new 5,8-quinoflavans from the leaf of Ilex centrochinensis.
abstract: Two new 5,8-quinoflavans were isolated from the leaf of Ilex centrochinensis, and their structures were elucidated as (2R)-7,3',4'-trimethoxy-5,8-quinoflavan and (2S)-7-methoxy-4'-hydroxy-5,8-quinoflavan on the basis of spectroscopic methods, especially 1D and 2D NMR, CD, and mass spectral analyses. Both of them exhibited weak cytotoxic activity against HuH7 cell lines and no cytotoxic activity against CaCO-2 cell lines.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Lu-Jun
authors.initials: LJ
authors.lastname: Li
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Pi
authors.forename: Han-Li
authors.initials: HL
authors.lastname: Ruan
authors.forename: Ji-Zhou
authors.initials: JZ
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018938:Caco-2 Cells; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D030017:Ilex / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
chemical_list: C558556:(2R)-7,3',4'-trimethoxy-5,8-quinoflavan; C558557:(2S)-7-methoxy-4'-hydroxy-5,8-quinoflavan; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids