title: Cytotoxic bibenzyls, and germacrane- and pinguisane-type sesquiterpenoids from Indonesian, Tahitian and Japanese liverworts.
abstract: Cytotoxic bibenzyls, and germacrane- and pinguisane-type sesquiterpenoids have been isolated from unidentified Indonesian and Tahitian Frullania sp. and Japanese Porella perrottetiana by using a combination of chromatographic methods. The structure activity relationship (SAR) study showed that the presence of a phthalide group in bibenzyls, an alpha-methylene-gamma-lactone in germacrane-type sesquiterpenoids, and beta-hydroxycarbonyl in pinguisane-type sesquiterpenoids play an important role in providing cytotoxic activity against both human promyelocytic leukemia (HL-60) and human pharyngeal squamous carcinoma (KB) cell lines. The structure of each isolated compound was elucidated by using spectroscopic methods and the cytotoxicity was determined by using the WST-8 colorimetric assay.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: Ismiarni
authors.initials: I
authors.lastname: Komala
authors.forename: Takuya
authors.initials: T
authors.lastname: Ito
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Nagashima
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yagi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D018922:HL-60 Cells; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D007202:Indicators and Reagents; D007214:Indonesia; D007564:Japan; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010936:Plant Extracts; D011114:Polynesia; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001593:Benzyl Compounds; D007202:Indicators and Reagents; D010936:Plant Extracts; D045788:Sesquiterpenes, Germacrane