title: Chemical study and antimalarial, antioxidant, and anticancer activities of Melaleuca armillaris (Sol Ex Gateau) Sm essential oil.
abstract: This study investigated the chemical composition (by using gas chromatography/flame ionization detection and gas chromatography/mass spectrometry, an antioxidant [1,1-diphenyl-2-picrylhydrazyl] [DPPH] radical-scavenging assay, and a 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonate [ABTS] radical cation-scavenging assay) and the antimalarial and cytotoxic activities of essential oil extracted from leaves of Melaleuca armillaris. Thirty-two components representing more than 98% of the total composition of the essential oil were identified. The main components were 1,8-cineole (85.8%), camphene (5.05%), and α-pinene (1.95%). The antioxidant activity by ABTS assay showed a mean (± standard deviation) 50% inhibitory concentration (IC(50)) value of 247.3 ± 3.9 mg/L, and the DPPH assay yielded an IC(50) value of 2183.6 ± 44.3 mg/L. The antimalarial study indicated that the essential oil had mild activity against the chloroquine-resistant Plasmodium falciparum FcB1 strain (IC(50), 27 ± 2 mg/L). The cytotoxic activity of this essential oil was tested against MCF7 human breast cancer cells and was found to be high (IC(50), 12 ± 1 mg/L).
authors.affiliation: Research Unit of Modeling, Analysis, and Control Systems, ENIG, Gabes, Tunisia.
authors.forename: Naziha
authors.initials: N
authors.lastname: Chabir
authors.forename: Mehrez
authors.initials: M
authors.lastname: Romdhane
authors.forename: Alexis
authors.initials: A
authors.lastname: Valentin
authors.forename: Béatrice
authors.initials: B
authors.lastname: Moukarzel
authors.forename: Hajer Naceur Ben
authors.initials: HN
authors.lastname: Marzoug
authors.forename: Nadia Ben
authors.initials: NB
authors.lastname: Brahim
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mars
authors.forename: Jalloul
authors.initials: J
authors.lastname: Bouajila
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D052160:Benzothiazoles / Q000032:analysis; D000081008:Bicyclic Monoterpenes; D001713:Biphenyl Compounds / Q000032:analysis; D002849:Chromatography, Gas / Q000379:methods; D003511:Cyclohexanols / Q000032:analysis; D000077591:Eucalyptol; D005410:Flame Ionization / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D031650:Melaleuca / Q000737:chemistry*; D039821:Monoterpenes / Q000032:analysis; D009822:Oils, Volatile / Q000494:pharmacology*; D010851:Picrates / Q000032:analysis; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013451:Sulfonic Acids / Q000032:analysis; D013729:Terpenes / Q000032:analysis
chemical_list: D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D052160:Benzothiazoles; D000081008:Bicyclic Monoterpenes; D001713:Biphenyl Compounds; D003511:Cyclohexanols; D039821:Monoterpenes; D009822:Oils, Volatile; D010851:Picrates; D010936:Plant Extracts; D013451:Sulfonic Acids; D013729:Terpenes; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C019286:camphene; C005451:alpha-pinene; D000077591:Eucalyptol