title: Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors.
abstract: We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.
authors.affiliation: School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
authors.forename: Osama
authors.initials: O
authors.lastname: Chahrour
authors.forename: Ashraf
authors.initials: A
authors.lastname: Abdalla
authors.forename: Frankie
authors.initials: F
authors.lastname: Lam
authors.forename: Carol
authors.initials: C
authors.lastname: Midgley
authors.forename: Shudong
authors.initials: S
authors.lastname: Wang
mesh_terms: D050256:Antimitotic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D013329:Structure-Activity Relationship; D013343:Styrenes / Q000737:chemistry*; D013441:Sulfinic Acids / Q000737:chemistry
chemical_list: D050256:Antimitotic Agents; D000970:Antineoplastic Agents; D013343:Styrenes; D013441:Sulfinic Acids; C044255:sulfonyl chloride