title: [Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay].
abstract: M. tuberculosis is a possible cause of uveitis; the diagnosis is often difficult. The aim of this study is to evaluate, in this context, the application of an interferon gamma assay, the SpotTB™. The prospective study, in patients presenting with uveitis without obvious cause and not resolving with local treatment, compared the therapeutic approach (giving antituberculous treatment or not) with and without the result of the SpotTB™. The analyses included 23 patients: 78% had received BCG; 78% had isolated ocular involvement; 22% had associated mediastinal lymphadenopathy. The results of the IDR and the SpotTB™ were concordant in 61%, discordant in 22% and non-evaluable in 17% of cases. In the patients with isolated ocular involvement the SpotTB™ avoided treatment in five and reinforced the decision not to treat in 13 others. In the patients with mediastinal lymphadenopathy, the SpotTB™ reinforced the diagnosis of sarcoidosis in four cases (one lost from view). In conclusion, when infection with M. tuberculosis is considered in the aetiology of uveitis the SpotTB™ allows, in a significant number of cases, the avoidance of antituberculous treatment.
authors.affiliation: Service de pneumologie, hôpital Saint-Antoine, 184 rue du Faubourg-Saint-Antoine, Paris cedex 12, France.
authors.forename: A
authors.initials: A
authors.lastname: Lino
authors.forename: V
authors.initials: V
authors.lastname: Lalande
authors.forename: A
authors.initials: A
authors.lastname: Guetta
authors.forename: B
authors.initials: B
authors.lastname: Lebeau
authors.forename: E
authors.initials: E
authors.lastname: Heron
authors.forename: C
authors.initials: C
authors.lastname: Chouaid
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D001500:BCG Vaccine; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011933:Reagent Kits, Diagnostic; D012507:Sarcoidosis / Q000175:diagnosis; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014374:Tuberculin Test; D014392:Tuberculosis, Ocular / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D014606:Uveitis, Anterior / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D014608:Uveoparotid Fever / Q000175:diagnosis
chemical_list: D000995:Antitubercular Agents; D001500:BCG Vaccine; D011933:Reagent Kits, Diagnostic; D007371:Interferon-gamma