title: The effect of nitrous oxide on intracuff pressure of the size 2 ProSeal Laryngeal Mask Airway.
abstract: OBJECTIVE
  To investigate intracuff pressure changes in the ProSeal Laryngeal Mask Airway (PLMA) during 50% nitrous oxide (N₂O) anesthesia.
  
  
  METHODS
  Prospective, randomized study.
  
  
  METHODS
  Operating room of a university-affiliated hospital.
  
  
  METHODS
  40 ASA 1 and 2 children, aged 2 to 6 years, weighing 10-20 kg, undergoing elective inguinal herniorrhaphy with general anesthesia.
  
  
  METHODS
  Patients were assigned to two groups (n = 20). Patients in Group A were anesthetized with 50% N(2)O in oxygen and sevoflurane, while patients in Group B were anesthetized with 50% air in oxygen and sevoflurane. PLMA cuffs were inflated with air. PLMA intracuff pressures starting from a baseline pressure of 30 mmHg were recorded using a pressure transducer for 30 minutes. The occurrence of postoperative throat discomfort was recorded.
  
  
  RESULTS
  In Group A, who inhaled 50% N₂O for 30 minutes, intracuff pressures reached 86.7 ± 10.4 mmHg, while in Group B, who inhaled 50% air for 30 minutes, intracuff pressures were 29.7 ± 1.0 mmHg. The postoperative throat complication rate in Group A was 45%, which was significantly higher than in Group B (5%).
  
  
  CONCLUSIONS
  PLMA intracuff pressure increased significantly during 50% N₂O anesthesia. The children's postoperative throat complication rate also was increased.
authors.affiliation: Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
authors.forename: Ben-Zhen
authors.initials: BZ
authors.lastname: Chen
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Luo
authors.forename: Lu
authors.initials: L
authors.lastname: Jiang
authors.forename: Ru-Rong
authors.initials: RR
authors.lastname: Wang
authors.forename: Jingxia
authors.initials: J
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Tan
mesh_terms: D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D017214:Laryngeal Masks / Q000009:adverse effects*; D009609:Nitrous Oxide / Q000009:adverse effects*; D010612:Pharyngitis / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology; D011312:Pressure; D011446:Prospective Studies
chemical_list: D018685:Anesthetics, Inhalation; D009609:Nitrous Oxide