title: Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells.
abstract: Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.
authors.affiliation: Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
authors.forename: Sabitha
authors.initials: S
authors.lastname: Aligeti
authors.forename: Nameer B
authors.initials: NB
authors.lastname: Kirma
authors.forename: Peter A
authors.initials: PA
authors.lastname: Binkley
authors.forename: Robert S
authors.initials: RS
authors.lastname: Schenken
authors.forename: Rajeshwar Rao
authors.initials: RR
authors.lastname: Tekmal
mesh_terms: D000704:Analysis of Variance; D019898:Autocrine Communication; D002448:Cell Adhesion; D002460:Cell Line; D002465:Cell Movement; D049109:Cell Proliferation; D018920:Coculture Techniques; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000235:genetics / Q000378:metabolism*; D010537:Peritoneum / Q000378:metabolism / Q000473:pathology; D034622:RNA Interference; D013997:Time Factors
chemical_list: D016173:Macrophage Colony-Stimulating Factor