title: Synthesis and anti-microbial evaluation of some novel 1,2,4-triazole derivatives.
abstract: Triazoles with different substituent groups are found to possess diverse applications in the field of medicine and industry. A series of 4-(substituted ethanoyl)amino-3-mercapto-5-(4-nitro)phenyl-1,2,4-triazoles (NU-1 to NU-15) were synthesized as novel antimicrobial agents starting from 4-nitrobenzoic acid. The chemical structures of these newly synthesized compounds were elucidated by IR, 1H NMR, 13C NMR, FAB+ -MS spectral data and elemental analysis. Their antimicrobial activities against Staphylococcus aureus (ATCC-25923), Pseudomonas aeruginosa (ATCC-27853), Escherichia coli (ATCC-8739), Bacillus substilis (ATCC-6633), Candida albicans (MTCC-227), Aspergillus niger (MTCC-3323) and Fusarium oxysporum (MTCC-2087) were investigated.
authors.affiliation: Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar (MP)-470003, India. neerajupmanyu2007@gmail.com
authors.forename: Neeraj
authors.initials: N
authors.lastname: Upmanyu
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kumar
authors.forename: Murali-Dhar
authors.initials: MD
authors.lastname: Kharya
authors.forename: Kamal
authors.initials: K
authors.lastname: Shah
authors.forename: Praadep
authors.initials: P
authors.lastname: Mishra
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D052978:Disk Diffusion Antimicrobial Tests; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects / Q000254:growth & development; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D014230:Triazoles; C045575:1,2,4-triazole