title: [Effect of ursodeoxycholic acid for reducing the deficit of vitamin D status and bone mineral density at gallstones].
abstract: OBJECTIVE
  To study the effect of ursodeoxycholic acid on vitamin D levels and bone mineral density (BMD) in patients with gallstone disease (GSD).
  
  
  METHODS
  BMD assessed by dual-energy X-ray densitometry in 53 patients with gallstone disease, of whom 21 patients received litolitic therapy at a daily dose of 10 mg/kg for 1,5-2 years. The control group consisted of 15 persons matched by sex and age.
  
  
  RESULTS
  Patients with gallstone disease treated with UDCA (ursosan), vitamin D deficiency was found in 5%, and in patient that didn't receive litolitic therapy--in 69% of cases.
  
  
  CONCLUSIONS
  Ursotherapy in patients with gallstone disease reduces vitamin D deficiency and is an effective measure to prevent osteopenia.
authors.forename: E S
authors.initials: ES
authors.lastname: Koricheva
authors.forename: A A
authors.initials: AA
authors.lastname: Il'chenko
authors.forename: V N
authors.initials: VN
authors.lastname: Drozdov
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D001851:Bone Diseases, Metabolic / Q000517:prevention & control; D002756:Cholagogues and Choleretics / Q000008:administration & dosage*; D005260:Female; D042882:Gallstones / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage*; D014808:Vitamin D Deficiency / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid