title: Inhibin-α immunohistochemical expression in mature and immature canine Sertoli and Leydig cells.
abstract: Formalin-fixed, paraffin-embedded sections from 32 canine pairs of testes were immunohistochemically examined for Inhibin-α (INHα). Samples were subdivided into two groups (group 1, neonates; group 2, puppies and adults) and results statistically compared. Inhibin-α was significantly expressed only in Sertoli cells of neonatal testes, while in Leydig cells it was expressed without significant difference between groups. These results suggest that, in dogs, INHα expression switches from Sertoli to Leydig cells during testicular maturation and that, in adult, Leydig cells represent the main source of INHα.
authors.affiliation: Faculty of Veterinary Medicine, Department of Veterinary Pathology, Hygiene and Public Health, Università degli Studi di Milano, Via Celoria, Milan, Italy. valeria.grieco@unimi.it
authors.forename: V
authors.initials: V
authors.lastname: Grieco
authors.forename: B
authors.initials: B
authors.lastname: Banco
authors.forename: A
authors.initials: A
authors.lastname: Ferrari
authors.forename: A
authors.initials: A
authors.lastname: Rota
authors.forename: M
authors.initials: M
authors.lastname: Faustini
authors.forename: M C
authors.initials: MC
authors.lastname: Veronesi
mesh_terms: D000375:Aging; D000818:Animals; D004285:Dogs / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D007150:Immunohistochemistry / Q000662:veterinary*; D007265:Inhibins / Q000235:genetics / Q000378:metabolism*; D007985:Leydig Cells / Q000378:metabolism*; D008297:Male; D012708:Sertoli Cells / Q000378:metabolism*
chemical_list: C094377:inhibin-alpha subunit; D007265:Inhibins