title: Lancifoliaine, a new bisbenzylisoquinoline from the bark of Litsea lancifolia.
abstract: A new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids--N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine--were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine, complete ¹³C-NMR data of N-allyl-laurolitsine (2) was also reported. The alkaloidal structures were elucidated by means of high field 1D- and 2D-NMR IR, UV, and LCMS-IT-TOF spectral data. N-Allyllaurolitsine (2) showed a moderate vasorelaxant activity on isolated rat aorta.
authors.affiliation: Centre for Natural Products and Drug Discovery, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Syazreen Nadia
authors.initials: SN
authors.lastname: Sulaiman
authors.forename: Mat Ropi
authors.initials: MR
authors.lastname: Mukhtar
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: Hazrina
authors.initials: H
authors.lastname: Hazni
authors.forename: Azeana
authors.initials: A
authors.lastname: Zahari
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Zaima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032862:Litsea / Q000737:chemistry*; D008297:Male; D024301:Plant Bark / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013057:Spectrum Analysis / Q000379:methods*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D007546:Isoquinolines