title: What are CX3CR1+ mononuclear cells in the intestinal mucosa?
abstract: Intestinal dendritic cells (DC) and macrophages play a key role for the maintenance of intestinal integrity by initiating innate and adaptive immune responses. Although DC and macrophages have been viewed as distinct lineages, the reliability of surface markers for the definition of DC and macrophages has recently been questioned. Here, I will discuss the ontogeny and function of CX(3)CR1(+) mononuclear cells in the small and large intestine.
authors.affiliation: Department of Internal Medicine I, Ulm University, Ulm, Germany. jan-hendrik.niess@uniklinik-ulm.de
authors.forename: Jan Hendrik
authors.initials: JH
authors.lastname: Niess
mesh_terms: D000818:Animals; D000073883:CX3C Chemokine Receptor 1; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000737:chemistry* / Q000276:immunology*; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D008264:Macrophages / Q000737:chemistry* / Q000276:immunology*; D019707:Receptors, Chemokine / Q000032:analysis*
chemical_list: D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D019707:Receptors, Chemokine