title: Isolated premature pubarche: report of anthropometric and metabolic profile of a Brazilian cohort of girls.
abstract: OBJECTIVE
  Isolated premature pubarche (PP) is commonly caused by premature adrenarche (PA), and links between PA, children born small for gestational age (SGA) and insulin resistance have already been made in some populations.
  
  
  METHODS
  We assessed anthropometric data, pubertal landmarks and metabolic profile at diagnosis and during the study in 52 girls with the diagnosis of isolated PP from a Brazilian cohort.
  
  
  RESULTS
  The prevalence of obesity (25%), dyslipidemia (63.5%) and born SGA children (21.2%) was greater among PP girls than in the reference population (4, 46.8 and 10%, respectively). There was no increase in the prevalence of insulin resistance and no correlation with birth weight, onset of PP or other pubertal signs. The Z score of heights at PP diagnosis was greater than the Z score of mid-parental height, but achieved final height (n = 16 girls, p = 0.002) was similar to normal population standards and to the predicted final height based on bone age at PP diagnosis (p = 0.08). Thelarche and menarche occurred at normal age, just earlier than expected.
  
  
  CONCLUSIONS
  The prevalence of children born SGA, obese and dyslipidemic, but not of hyperinsulinemic children, was high in our cohort of PP girls. Puberty started earlier than usual but within the normal range.
authors.affiliation: Department of Endocrinology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. kferran@hucff.ufrj.br
authors.forename: Karina
authors.initials: K
authors.lastname: de Ferran
authors.forename: Isla Aguiar
authors.initials: IA
authors.lastname: Paiva
authors.forename: Leonardo dos Santos
authors.initials: Ldos S
authors.lastname: Garcia
authors.forename: Maurício de Pinho
authors.initials: Mde P
authors.lastname: Gama
authors.forename: Marilia Martins
authors.initials: MM
authors.lastname: Guimarães
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001837:Body Weights and Measures; D001938:Brazil; D002648:Child; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008572:Menarche / Q000502:physiology; D055442:Metabolome / Q000502:physiology; D011629:Puberty, Precocious / Q000097:blood / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology*; D012189:Retrospective Studies; D055815:Young Adult