title: Stable water-dispersed organic nanoparticles: preparation, optical properties, and cell imaging application.
abstract: Water-dispersed organic nanoparticles (NPs) constructed by the conjugated molecule 2,5,2',5'-tetra(4'-N,N-diphenylaminostyryl)biphenyl (DPA-TSB) with a high luminescence and large two-photon absorption (TPA) section were fabricated via the reprecipitation method. The average size of the NPs can be controlled from 40 nm to 80 nm by adjusting the reprecipitation conditions. The NPs in water dispersions showed high aggregative and optical stability, which were due to contributions from the special cruciform configuration and amorphous nature of DPA-TSB molecules. The cellular uptake behavior of DPA-TSB NPs was investigated to show their cell staining capabilities as nanoprobes using a confocal microscopy test in vitro. The results demonstrated that DPA-TSB NPs were readily internalized into cytoplasm with no apparent toxicity for up to 24 h, implying excellent imaging capabilities.
authors.affiliation: State Key Lab of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, PR China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Yang
authors.forename: Dan
authors.initials: D
authors.lastname: Lu
authors.forename: Leilei
authors.initials: L
authors.lastname: Tian
authors.forename: Feng
authors.initials: F
authors.lastname: He
authors.forename: Geng
authors.initials: G
authors.lastname: Chen
authors.forename: Fangzhong
authors.initials: F
authors.lastname: Shen
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Ma
mesh_terms: D003102:Colloids / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008853:Microscopy / Q000379:methods*; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D009930:Organic Chemicals; D010316:Particle Size; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
chemical_list: D003102:Colloids; D003287:Contrast Media; D046911:Macromolecular Substances; D009930:Organic Chemicals; D014867:Water