title: Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum.
abstract: An anticancer-bioassay guided isolation of the ethanol extract and fractions of two plants from the Peruvian rainforest, Mikania decora and Cremastosperma microcarpum, led to the characterization of one abundant diterpene, ent-pimara-8(14),15-dien-19-oic acid (1), three thymol derivatives, 10-acetoxy-8,9-dehydro-6-methoxythymol butyrate (2), 10-acetoxy-8,9-epoxy-6-methoxythymol isobutyrate (3), and acetylschizoginol (4), as well as one neolignan, (±)-trans-dehydrodiisoeugenol (5). Only the latter was isolated from C. microcarpum. These compounds exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 3 and 4 were also investigated for their in vitro antileishmanial and trypanocidal activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes.
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, KY, USA.
authors.forename: José C
authors.initials: JC
authors.lastname: Aponte
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Jin
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Vaisberg
authors.forename: Denis
authors.initials: D
authors.lastname: Castillo
authors.forename: Edith
authors.initials: E
authors.lastname: Málaga
authors.forename: Walter H
authors.initials: WH
authors.lastname: Lewis
authors.forename: Michel
authors.initials: M
authors.lastname: Sauvain
authors.forename: Robert H
authors.initials: RH
authors.lastname: Gilman
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D035742:Mikania / Q000737:chemistry*; D021261:Parasitic Sensitivity Tests; D010568:Peru; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013943:Thymol / Q000737:chemistry / Q000494:pharmacology; D014197:Trees; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D004224:Diterpenes; D017705:Lignans; D010936:Plant Extracts; D013943:Thymol