title: Cytomegalovirus e127 protein interacts with the inhibitory CD200 receptor.
abstract: CD200 is a cell surface glycoprotein that binds an inhibitory receptor (CD200R) on myeloid cells. CD200 orthologues are present in many species of virus, and we show that the rat cytomegalovirus CD200 orthologue (e127) is expressed at the cell surface on infected cells. It binds the host CD200R with the same affinity as that of the host protein, and thus this protein acts as a close mimic of the host protein and has the potential to downregulate immune responses to the virus.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.
authors.forename: Mildred
authors.initials: M
authors.lastname: Foster-Cuevas
authors.forename: Tina
authors.initials: T
authors.lastname: Westerholt
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ahmed
authors.forename: Marion H
authors.initials: MH
authors.lastname: Brown
authors.forename: A Neil
authors.initials: AN
authors.lastname: Barclay
authors.forename: Sebastian
authors.initials: S
authors.lastname: Voigt
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000378:metabolism*; D005434:Flow Cytometry; D017737:Macrophages, Peritoneal / Q000378:metabolism; D018146:Muromegalovirus / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D011956:Receptors, Cell Surface; D014764:Viral Proteins; C042739:antigens, CD200