title: Composition, and antimicrobial and remarkable antiprotozoal activities of the essential oil of rhizomes of Aframomum sceptrum K. Schum. (Zingiberaceae).
abstract: The essential oil from the rhizomes of Aframomum sceptrum (Zingiberaceae) was analyzed by GC/MS, and its major constituents were found to be β-pinene (12.7%), caryophyllene oxide (10.0%), and cyperene (6.0%). The oil was also evaluated for antimicrobial activities, in comparison with β-pinene, caryophyllene oxide, and the leaf essential oil of Melaleuca alternifolia (Myrtaceae). The A. sceptrum essential oil exhibited bacteriostatic activity against the Gram-positive bacteria Bacillus subtilis, Staphylococcus epidermidis, and S. aureus, but not against Gram-negative bacteria. Moreover, it showed mild fungicidal activity against Candida albicans and Aspergillus fumigates, and remarkable antiprotozoal activity against Trypanosoma brucei brucei (MLC of 1.51 μl/ml) and Trichomonas vaginalis (IC(50) of 0.12±0.02 and MLC of 1.72 μl/ml).
authors.affiliation: Chimie des substances naturelles et chimiothérapie antiparasitaire, CNRS UMR 8076 BioCIS, Faculté de Pharmacie, Université Paris-Sud, F-92296 Châtenay-Malabry. pierre.champy@u-psud.fr
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Cheikh-Ali
authors.forename: Marcelline
authors.initials: M
authors.lastname: Adiko
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bouttier
authors.forename: Christian
authors.initials: C
authors.lastname: Bories
authors.forename: Timothée
authors.initials: T
authors.lastname: Okpekon
authors.forename: Erwan
authors.initials: E
authors.lastname: Poupon
authors.forename: Pierre
authors.initials: P
authors.lastname: Champy
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002417:Cattle; D005658:Fungi / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009181:Mycoses / Q000188:drug therapy; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000081223:Polycyclic Sesquiterpenes; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014354:Trypanosomiasis, Bovine / Q000188:drug therapy; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C010789:beta-pinene; C515179:caryophyllene oxide