title: Antitumour activity of Prosopis cineraria (L.) Druce against Ehrlich ascites carcinoma-induced mice.
abstract: The antitumour activity of the hydroalcoholic extract of the leaf (PCL) and stem bark (PCB) of Prosopis cineraria (L.) in Swiss albino mice was evaluated against an Ehrlich ascites carcinoma (EAC) tumour model. The activity was assessed using survival time, peritoneal cells, haematological studies, lipid peroxidation, antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, solid tumour mass and in vitro cytotoxicity. PCL and PCB were found to be potent and possessed significant cytotoxicity towards EAC tumour cells.
authors.affiliation: Department of Pharmacognosy, Maharaji College of Pharmacy, Chennai 600090, Tamil Nadu, India. uystella_mpharm@yahoo.co.in
authors.forename: Stellaa
authors.initials: S
authors.lastname: Robertson
authors.forename: N
authors.initials: N
authors.lastname: Narayanan
authors.forename: B
authors.initials: B
authors.lastname: Raj Kapoor
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D029862:Prosopis / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts