title: Molecular epidemiology of rabies virus circulating in South Korea, 1998-2010.
abstract: We analyzed the nucleotide sequences of the G-L (glycoprotein-large protein) intergenic non-coding region of 33 strains of the rabies virus (RABV) isolated in South Korea in 1998-2010 and compared the sequences with those of previously reported non-Korean strains. The similarities of the nucleotide sequences of the G-L region among all Korean RABV isolates ranged from 97.1 to 100%. Based on the phylogenetic analysis of the G-L region, the Korean RABV isolates were classified into three distinct subgroups with high similarity and were most closely related to the non-Korean NeiMeng1025C isolate, which was isolated from a rabid raccoon dog in eastern China, suggesting that the Korean RABV isolates originate from a rabid raccoon dog in northeastern Asia. Our results indicated that G-L region, as a useful phylogenetic indicator, is equivalent to the nucleoprotein (N) or glycoprotein (G) gene for study of RABV molecular epidemiology and that the Korean RABV isolates showing a few substitutions in the G-L region are continuously circulating in South Korea.
authors.affiliation: National Veterinary Research and Quarantine Service, MIFAFF, Anyang 430–757, Korea. yangdk@korea.kr
authors.forename: Dong-Kun
authors.initials: DK
authors.lastname: Yang
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Shin
authors.forename: Yoon-I
authors.initials: YI
authors.lastname: Oh
authors.forename: Hee-Kyung
authors.initials: HK
authors.lastname: Kang
authors.forename: Kyung-Woo
authors.initials: KW
authors.lastname: Lee
authors.forename: Soo-Dong
authors.initials: SD
authors.lastname: Cho
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Song
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology* / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D004283:Dog Diseases / Q000453:epidemiology* / Q000821:virology; D004285:Dogs; D006023:Glycoproteins / Q000235:genetics; D017720:Molecular Epidemiology; D010802:Phylogeny; D011818:Rabies / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D011820:Rabies virus / Q000235:genetics* / Q000302:isolation & purification; D056910:Republic of Korea / Q000453:epidemiology; D014764:Viral Proteins / Q000235:genetics
chemical_list: D004279:DNA, Viral; D006023:Glycoproteins; D014764:Viral Proteins; C097625:L protein, Rabies virus; D012321:DNA-Directed RNA Polymerases