title: Early bone formation around immediately loaded FBR-coated implants after 8, 10 and 12 weeks: a human histologic evaluation of three retrieved implants.
abstract: The surface characteristics of dental implants play an important role in the osseointegration process. Over the years implant surfaces have been subjected to different treatments, including turning, plasma spraying, coating, sand blasting, acid etching, and anodization. FBR coating is a fully resorbable calcium phosphate (CaP) coating made of brushite, obtained by electrochemical deposition on titanium plasma-sprayed (TPS) implants; this bioactive layer may be totally resorbable in 6-12 weeks and once the FBR coating has been resorbed, the newly formed bone is in contact with the roughness of the TPS surface. Human biopsy of immediately-loaded implants is certainly the most definitive means of determining the occurrence of osseointegration. In this case series the histologic and histomorphometric features of the bone-implant interface are analyzed and discussed in 3 immediately restored implants, retrieved from human subjects at 8, 10 and 12 weeks, respectively. All 3 implants were osseointegrated, with a bone to implant contact (BIC) ranging from 54.4% to 70.1%. The FBR coating was resorbed and replaced by new bone. Osteoconduction was especially noticeable between the implant threads, where the pristine bone was removed during implant bed preparation. The results suggest that the resorption window of 6-12 weeks for the CaP coating seems to be confirmed at least in the human mandible, and that immediately loaded FBR-coated implants placed in the posterior mandible can achieve osseointegration within 6-12 weeks of loading.
authors.affiliation: Faculty of Medicine, Dentistry and Maxillofacial Surgery Clinic, University of Verona, Verona, Italy. research.univr@hotmail.it
authors.forename: L
authors.initials: L
authors.lastname: Malchiodi
authors.forename: P
authors.initials: P
authors.lastname: Ghensi
authors.forename: A
authors.initials: A
authors.lastname: Cucchi
authors.forename: P
authors.initials: P
authors.lastname: Trisi
authors.forename: S
authors.initials: S
authors.lastname: Szmukler-Moncler
authors.forename: G
authors.initials: G
authors.lastname: Corrocher
authors.forename: R
authors.initials: R
authors.lastname: Gerosa
mesh_terms: D000328:Adult; D000368:Aged; D001861:Bone Regeneration; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D005260:Female; D006801:Humans; D057893:Immediate Dental Implant Loading; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis; D012189:Retrospective Studies; D013499:Surface Properties; D013997:Time Factors
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants