title: Celsior versus University of Wisconsin preserving solutions for liver transplantation: postreperfusion syndrome and outcome of a 5-year prospective randomized controlled study.
abstract: BACKGROUND
  Celsior solution (CS) is a high-sodium, low-potassium, low-viscosity extracellular solution that has been used for liver graft preservation in recent years, although experience with it is still limited. We performed an open-label randomized active-controlled trial comparing CS with the University of Wisconsin solution (UW) for liver transplantation (LT), with a follow-up period of 5 years.
  
  
  METHODS
  Adult transplant recipients (n=102) were prospectively randomized to receive either CS (n=51) or UW (n=51). The two groups were comparable with respect to donor and recipient characteristics. The primary outcome measure was the incidence of postreperfusion syndrome (PRS). Secondary outcome measures included primary nonfunction (PNF) or primary dysfunction (PDF), liver retransplantation, and graft and patient survival. Other secondary outcome measures were days in the intensive care unit (ICU) and the rates of acute rejection, chronic rejection, infectious complications, postoperative reoperations, and vascular and biliary complications.
  
  
  RESULTS
  In all, 14 posttransplant variables revealed no significant differences between the groups. There were no cases of PNF or PDF. The incidence of PRS was 5.9% in the CS group and 21.6% in the UW group (P=0.041). After reperfusion, CS revealed greater control of serum potassium (P=0.015), magnesium levels (P=0.005), and plasma glucose (P=0.042) than UW. Respective patient survivals at 3, 12, and 60 months were 95.7, 87.2, and 82.0% for the CS group and 95.7, 83.3, and 66.6% for the UW group (P=0.123).
  
  
  CONCLUSIONS
  While retaining the same degree of safety and effectiveness as UW for LT, CS may yield postliver graft reperfusion benefits, as shown in this study by a significant reduction in the incidence of PRS and greater metabolic control.
authors.affiliation: Department of Surgery, University of Zaragoza, Domingo Miral s/n, 50009, Zaragoza, Spain. agarciagil@telefonica.net
authors.forename: Francisco A
authors.initials: FA
authors.lastname: García-Gil
authors.forename: María T
authors.initials: MT
authors.lastname: Serrano
authors.forename: Lorena
authors.initials: L
authors.lastname: Fuentes-Broto
authors.forename: Juan
authors.initials: J
authors.lastname: Arenas
authors.forename: José J
authors.initials: JJ
authors.lastname: García
authors.forename: Antonio
authors.initials: A
authors.lastname: Güemes
authors.forename: Vanesa
authors.initials: V
authors.lastname: Bernal
authors.forename: Ana
authors.initials: A
authors.lastname: Campillo
authors.forename: Carlos
authors.initials: C
authors.lastname: Sostres
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Araiz
authors.forename: Pablo
authors.initials: P
authors.lastname: Royo
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Simón
mesh_terms: D000241:Adenosine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000493:Allopurinol; D004187:Disaccharides; D004573:Electrolytes; D005260:Female; D005500:Follow-Up Studies; D005971:Glutamates; D005978:Glutathione; D006639:Histidine; D006801:Humans; D007328:Insulin; D016031:Liver Transplantation; D008297:Male; D008353:Mannitol; D008875:Middle Aged; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011887:Raffinose; D015427:Reperfusion Injury / Q000517:prevention & control*; D013577:Syndrome; D013997:Time Factors; D055815:Young Adult
chemical_list: C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D006639:Histidine; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose