title: Osmotically controlled drug delivery system with associated drugs.
abstract: Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain molecules may have low oral bioavailability because of solubility or permeability limitations. Development of an extended release dosage form also requires reasonable absorption throughout the gastro-intestinal tract (GIT). Among the available techniques to improve the bioavailability of these drugs fabrication of osmotic drug delivery system is the most appropriate one. Osmotic drug delivery systems release the drug with the zero order kinetics which does not depend on the initial concentration and the physiological factors of GIT. This review brings out new technologies, fabrication and recent clinical research in osmotic drug delivery.
authors.affiliation: Sagar Institute of Research & Technology-Pharmacy, SIRT- Campus Bhopal, India. guptabrahma@gmail.com
authors.forename: Brahma Prakash
authors.initials: BP
authors.lastname: Gupta
authors.forename: Navneet
authors.initials: N
authors.lastname: Thakur
authors.forename: Nishi P
authors.initials: NP
authors.lastname: Jain
authors.forename: Jitendra
authors.initials: J
authors.lastname: Banweer
authors.forename: Surendra
authors.initials: S
authors.lastname: Jain
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006801:Humans; D009997:Osmotic Pressure; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations