title: Single-dose antibiotic prophylaxis for urinary catheter removal does not reduce the risk of urinary tract infection in surgical patients: a randomized double-blind placebo-controlled trial.
abstract: We conducted a double-blind, placebo-controlled randomized trial to assess the effect of single-dose prophylaxis using co-trimoxazole (960 mg) (n = 46) or ciprofloxacin (500 mg) (n = 43) vs. placebo (n = 51) before urinary catheter removal on significant bacteriuria (SBU) (primary outcome) and urinary tract infection (UTI) in surgical patients with scheduled bladder drainage for 3-14 days. SBU was determined directly after catheter removal, and UTI 12-14 days after catheter removal. After 12-14 days, incidences of SBU were 19%, 19% and 33% for patients receiving ciprofloxacin, co-trimoxazole and placebo, respectively (p ns), and incidences of UTI were 3%, 0% and 3% for patients receiving ciprofloxacin, co-trimoxazole and placebo, respectively (p ns).
authors.affiliation: Department of Medical Microbiology and Immunology, St Antonius Hospital, Nieuwegein, the Netherlands.
authors.forename: B C
authors.initials: BC
authors.lastname: van Hees
authors.forename: P L M
authors.initials: PL
authors.lastname: Vijverberg
authors.forename: L E
authors.initials: LE
authors.lastname: Hoorntje
authors.forename: E H H
authors.initials: EH
authors.lastname: Wiltink
authors.forename: P M N Y H
authors.initials: PM
authors.lastname: Go
authors.forename: M
authors.initials: M
authors.lastname: Tersmette
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D001437:Bacteriuria / Q000453:epidemiology / Q000517:prevention & control*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010919:Placebos / Q000008:administration & dosage; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D010919:Placebos; D002939:Ciprofloxacin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination