title: Association between serum cystatin C, monocytes and other inflammatory markers.
abstract: BACKGROUND
  Cystatin C is a marker of renal function that appears to be associated with inflammation. The aim of the present study was to investigate whether there is any relationship between cystatin C, total and differential leukocyte count and other inflammatory markers.
  
  
  METHODS
  Cystatin C, creatinine, high sensitivity C-reactive protein (hs-CRP), haptoglobin, ferritin, serum albumin, glucose, total cholesterol, HDL and triglycerides together with total and differential leukocyte count were determined in 490 adults (46 ± 16 years, 40% men) who underwent a typical health examination. Glomerular filtration rate was estimated by the simplified Modification of Diet in Renal Disease formula. Anthropometric and lifestyle characteristics were also recorded.
  
  
  RESULTS
  After adjustment for demographic risk factors, comorbid health conditions and renal function, a positive and independent relationship of serum cystatin C levels with peripheral monocyte blood count (regression coefficient ± SE: 12 ± 3.38, P < 0.001) and white blood count (0.616 ± 0.278, P= 0.027) was evident. In this multiple linear regression analysis, other inflammatory markers (i.e. hs-CRP, haptoglobin, ferritin, albumin) did not seem to affect cystatin C blood levels.
  
  
  CONCLUSIONS
  The results of this study demonstrated that monocytes, which play an important role in chronic inflammation and atherosclerosis, were independently related with cystatin C concentrations. This finding may provide a plausible link for the usefulness of cystatin C in predicting increased cardiovascular risk.
authors.affiliation: Department of Internal Medicine, Polykliniki General Hospital, Athens, Greece.
authors.forename: A A
authors.initials: AA
authors.lastname: Evangelopoulos
authors.forename: N G
authors.initials: NG
authors.lastname: Vallianou
authors.forename: V
authors.initials: V
authors.lastname: Bountziouka
authors.forename: C
authors.initials: C
authors.lastname: Katsagoni
authors.forename: E
authors.initials: E
authors.lastname: Bathrellou
authors.forename: E D
authors.initials: ED
authors.lastname: Vogiatzakis
authors.forename: M S
authors.initials: MS
authors.lastname: Bonou
authors.forename: J
authors.initials: J
authors.lastname: Barbetseas
authors.forename: P C
authors.initials: PC
authors.lastname: Avgerinos
authors.forename: D B
authors.initials: DB
authors.lastname: Panagiotakos
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D002908:Chronic Disease; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism* / Q000473:pathology; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D018836:Inflammation Mediators