title: Emerging strategies for the early detection and prevention of head and neck squamous cell cancer.
abstract: Despite significant improvements in therapeutic protocols, head and neck squamous cell carcinoma (HNSCC) remains a major health problem worldwide. The 5-year post-therapeutic survival rate is among the lowest of the major cancers with loco-regional relapse being the main cause of death. Moreover, in most instances, the quality of life of the afflicted patient is severely compromised. The poor prognosis for HNSCC is primarily due to disease detection at advanced stages. Accordingly, development of early detection and preventive strategies are essential. Recent advances in our understanding of the molecular biology and etiology of HNSCC should facilitate development of improved intervention and therapeutic approaches. The present review discusses the potential role of such factors for developing preventive and early diagnostic strategies for HNSCC management.
authors.affiliation: Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA. sdasgupta@vcu.edu
authors.forename: Santanu
authors.initials: S
authors.lastname: Dasgupta
authors.forename: Rupesh
authors.initials: R
authors.lastname: Dash
authors.forename: Swadesh K
authors.initials: SK
authors.lastname: Das
authors.forename: Devanand
authors.initials: D
authors.lastname: Sarkar
authors.forename: Paul B
authors.initials: PB
authors.lastname: Fisher
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000517:prevention & control*; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D018307:Neoplasms, Squamous Cell / Q000175:diagnosis* / Q000517:prevention & control*; D012307:Risk Factors
chemical_list: D009363:Neoplasm Proteins