title: Synthesis of Pyrrolo[1,2-a]quinoxalines via gold(I)-mediated cascade reactions.
abstract: In this study, we developed an efficient tandem process of hydroamination and hydroarylation using a gold catalyst to enable and study the reactions between pyrrole-substituted anilines and alkynes. The gold(I)-catalyzed reactions were achieved in toluene at 80 °C over a reaction time of 1−6 h. These reactions are applicable to a variety of aromatic amino compounds and both the terminal and internal alkynes. Substituted pyrrolo[1,2-a]quinoxalines were obtained in moderate to excellent yields. A presumed mechanism involving intermolecular C−N bond formation and intramolecular nucleophilic reaction via a cationic gold complex has been proposed on the basis of the deuterium labeling studies.
authors.forename: Guannan
authors.initials: G
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Daizong
authors.initials: D
authors.lastname: Lin
authors.forename: Jinfang
authors.initials: J
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Hualiang
authors.initials: H
authors.lastname: Jiang
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
mesh_terms: D006046:Gold / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature
chemical_list: D011758:Pyrroles; D011810:Quinoxalines; C531444:pyrrolo(1,2-a)quinoxaline; D006046:Gold