title: A validated CFD model to predict O₂ and CO₂ transfer within hollow fiber membrane oxygenators.
abstract: Hollow fiber oxygenators provide gas exchange to and from the blood during heart surgery or lung recovery. Minimal fiber surface area and optimal gas exchange rate may be achieved by optimization of hollow fiber shape and orientation (1). In this study, a modified CFD model is developed and validated with a specially developed micro membrane oxygenator (MicroMox). The MicroMox was designed in such a way that fiber arrangement and bundle geometry are highly reproducible and potential flow channeling is avoided, which is important for the validation. Its small size (V(Fluid)=0.04 mL) allows the simulation of the entire bundle of 120 fibers. A non-Newtonian blood model was used as simulation fluid. Physical solubility and chemical bond of O₂ and CO₂ in blood was represented by the numerical model. Constant oxygen partial pressure at the pores of the fibers and a steady state flow field was used to calculate the mass transport. In order to resolve the entire MicroMox fiber bundle, the mass transport was simulated for symmetric geometry sections in flow direction. In vitro validation was achieved by measurements of the gas transfer rates of the MicroMox. All measurements were performed according to DIN EN 12022 (2) using porcine blood. The numerical simulation of the mass transfer showed good agreement with the experimental data for different mass flows and constant inlet partial pressures. Good agreement could be achieved for two different fiber configurations. Thus, it was possible to establish a validated model for the prediction of gas exchange in hollow fiber oxygenators.
authors.affiliation: Department of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany. hormes@hia.rwth-aachen.de
authors.forename: Marcus
authors.initials: M
authors.lastname: Hormes
authors.forename: Ralf
authors.initials: R
authors.lastname: Borchardt
authors.forename: Ilona
authors.initials: I
authors.lastname: Mager
authors.forename: Thomas Schmitz
authors.initials: TS
authors.lastname: Rode
authors.forename: Marek
authors.initials: M
authors.lastname: Behr
authors.forename: Ulrich
authors.initials: U
authors.lastname: Steinseifer
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D003198:Computer Simulation; D004867:Equipment Design; D008962:Models, Theoretical; D010100:Oxygen / Q000097:blood*; D010107:Oxygenators, Membrane; D010313:Partial Pressure; D013552:Swine
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen