title: Interaction of C60 fullerene with the proteins involved in DNA mismatch repair pathway.
abstract: Fullerenes are fascinating symmetric carbon nanostructures with a potential to bind DNA and proteins. Computational studies were performed to investigate the interaction of fullerenes with the proteins involved in DNA mismatch repair (MMR) pathway. Significant interactions of fullerene with PMS2, RFC3 and PCNA proteins were observed. These findings suggested that fullerene interferes in the human MMR process hence the subsequent disturbance may confer a large increase in spontaneous mutability and a strong predisposition to tumor development.
authors.affiliation: Nanomaterial Toxicology Group, Indian Institute of Toxicology Research (CSIR), P.O. Box 80, M. G. Marg, Lucknow 226001, India.
authors.forename: Shishir Kumar
authors.initials: SK
authors.lastname: Gupta
authors.forename: Lokesh
authors.initials: L
authors.lastname: Baweja
authors.forename: Deepak
authors.initials: D
authors.lastname: Gurbani
authors.forename: Alok K
authors.initials: AK
authors.lastname: Pandey
authors.forename: Alok
authors.initials: A
authors.lastname: Dhawan
mesh_terms: D020137:Base Pair Mismatch; D001665:Binding Sites; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure*; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D008956:Models, Chemical; D008958:Models, Molecular; D011485:Protein Binding
chemical_list: D004268:DNA-Binding Proteins; D004247:DNA