title: Processive ubiquitin chain formation by the anaphase-promoting complex.
abstract: Progression through mitosis requires the sequential ubiquitination of cell cycle regulators by the anaphase-promoting complex, resulting in their proteasomal degradation. Although several mechanisms contribute to APC/C regulation during mitosis, the APC/C is able to discriminate between its many substrates by exploiting differences in the processivity of ubiquitin chain assembly. Here, we discuss how the APC/C achieves processive ubiquitin chain formation to trigger the sequential degradation of cell cycle regulators during mitosis.
authors.affiliation: University of California at Berkeley, Department of Molecular and Cell Biology, Berkeley, CA 94720-3202, United States.
authors.forename: Hermann-Josef
authors.initials: HJ
authors.lastname: Meyer
authors.forename: Michael
authors.initials: M
authors.lastname: Rape
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008322:Mammals; D008938:Mitosis; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding / Q000235:genetics; D059748:Proteolysis; D013379:Substrate Specificity; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism*; D044763:Ubiquitin-Conjugating Enzymes / Q000235:genetics / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D025801:Ubiquitin; D044763:Ubiquitin-Conjugating Enzymes; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D046988:Proteasome Endopeptidase Complex