title: Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats.
abstract: Cognitive disorders after epilepsy can have a great impact on the quality of life of epileptic patients, though it has not drawn much attention. Even after identified, it is often undertreated or has gone untreated. Memantine has been approved to treat moderate to severe Alzheimer disease (AD), which is characterized by cognitive impairment. In present study, we determined the effects of memantine on PTZ-kindled rats, which can mimic the postseizure dysfunction that resembles symptoms observed in human epilepsy. We found that memantine can ameliorate the spatial learning and memory of epileptic rats. But contrary to previous claims that memantine can improve cognition in AD patients, without serious side effects on normal learning and memory abilities, we found that rats treated only with memantine exhibited the impaired spatial learning and memory ability. We conclude that memantine can improve cognition related to an excitotoxicity-induced pathologic state, but the potential side effects of memantine on the physiological processes should be considered.
authors.affiliation: Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China. jialeishi@126.com
authors.forename: Li-Jing
authors.initials: LJ
authors.lastname: Jia
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Wang
authors.forename: Zhou-Ping
authors.initials: ZP
authors.lastname: Li
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Zhen
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: An
authors.forename: Rui-Sheng
authors.initials: RS
authors.lastname: Duan
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003292:Convulsants; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects*; D007859:Learning Disabilities / Q000139:chemically induced* / Q000188:drug therapy*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008559:Memantine / Q000494:pharmacology*; D008569:Memory Disorders / Q000139:chemically induced* / Q000188:drug therapy*; D009068:Movement / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology; D010433:Pentylenetetrazole; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000523:psychology*; D013028:Space Perception / Q000187:drug effects; D013550:Swimming / Q000523:psychology
chemical_list: D003292:Convulsants; D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D008559:Memantine; D010433:Pentylenetetrazole