title: Genetic diversity and multiple introductions of porcine reproductive and respiratory syndrome viruses in Thailand.
abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is prevalent in Thailand, causing a huge impact on the country's swine industry. Yet the diversity and origin of these Thai PRRSVs remained vague. In this context, we collected all the Thai PRRSV sequences described earlier and incorporated them into the global diversity. The results indicated that PRRSVs in Thailand were originated from multiple introductions involving both Type 1 and Type 2 PRRSVs. Many of the introductions were followed by extensive geographic expansion, causing regional co-circulation of diverse PRRSV variants in three major pig-producing provinces. Based on these results, we suggest (1) to avoid blind vaccination and to apply vaccines tailor-made for target diversity, (2) to monitor pig importation and transportation, and (3) to implement a better biosecurity to reduce horizontal transmissions as three potentially effective strategies of controlling PRRS in Thailand.
authors.affiliation: School of Biological Sciences, University of Hong Kong, Hong Kong SAR, China.
authors.forename: Hein M
authors.initials: HM
authors.lastname: Tun
authors.forename: Mang
authors.initials: M
authors.lastname: Shi
authors.forename: Charles L Y
authors.initials: CL
authors.lastname: Wong
authors.forename: Suparlark N N
authors.initials: SN
authors.lastname: Ayudhya
authors.forename: Alongkorn
authors.initials: A
authors.lastname: Amonsin
authors.forename: Roongroje
authors.initials: R
authors.lastname: Thanawonguwech
authors.forename: Frederick C C
authors.initials: FC
authors.lastname: Leung
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods; D014644:Genetic Variation; D005838:Genotype; D017720:Molecular Epidemiology; D010802:Phylogeny; D058974:Phylogeography; D019318:Porcine Reproductive and Respiratory Syndrome / Q000453:epidemiology* / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000235:genetics; D013552:Swine; D013785:Thailand / Q000453:epidemiology
chemical_list: D012367:RNA, Viral