title: [Clinical experience with daptomycin use in Spain. Global findings from EU-CORE database].
abstract: The European Cubicin(®) Outcome Registry and Experience (EU-CORE) is a retrospective, non-interventional, multicenter database of daptomycin use in several European countries. This database provides information on the routine use of this antibiotic to treat various infections caused by Gram-positive microorganisms. This article describes the demography, clinical characteristics, and outcomes of patients treated in Spanish hospitals participating in the EUCORE database, as well as the types of infection and causal pathogens involved. Overall, most indications and dosing regimens of daptomycin were within the health authorities' approved criteria, although the antibiotic was sometimes used for other clinical situations and at doses higher than those currently established. Daptomycin was mainly used as rescue therapy, and the efficacy and safety of the drug were very high. The experience gained with the EUCORE database suggests that daptomycin may be suitable for application in potentially severe infections caused by several species of Gram-positive microorganisms.
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Universitario Vall d'Hebron, Barcelona, España. balmirante@vhebron.net
authors.forename: Benito
authors.initials: B
authors.lastname: Almirante
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology; D015897:Comorbidity; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology; D017576:Daptomycin / Q000627:therapeutic use*; D016208:Databases, Factual / Q000706:statistics & numerical data*; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000453:epidemiology; D016983:Enterococcus / Q000187:drug effects; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy / Q000453:epidemiology; D011358:Product Surveillance, Postmarketing; D012042:Registries / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D016879:Salvage Therapy; D018461:Soft Tissue Infections / Q000188:drug therapy / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin