title: Achieving STOP TB Partnership goals: perspectives on development of new diagnostics, drugs and vaccines for tuberculosis.
abstract: Global eradication of tuberculosis (TB) depends on identification and treatment of all active TB cases and of the two billion people who are estimated to be latently infected with Mycobacterium tuberculosis. The past decade has seen a renaissance of scientific activities and funder investment into development of new TB drugs, diagnostics, biomarkers and vaccines. This viewpoint critically summarises the promising portfolio of more accurate TB diagnostics, new TB drugs and vaccines that have been endorsed by the STOP TB Partnership. Increasing numbers of Phase 2 and 3 drug, vaccine and diagnostic clinical trials in high-TB endemic areas reflect substantial progress towards attaining Global STOP-TB Partnership targets. Achievement of STOP-TB Partnership goals will crucially depend on political will and serious investment by funders and developing country governments into improving delivery of better health services and living conditions for their people. Long-term sustainability of any newer tools implemented at point of care is essential.
authors.affiliation: Ministry of Health, Lusaka, Zambia.
authors.forename: Peter
authors.initials: P
authors.lastname: Mwaba
authors.forename: Ruth
authors.initials: R
authors.lastname: McNerney
authors.forename: Martin Peter
authors.initials: MP
authors.lastname: Grobusch
authors.forename: Justin
authors.initials: J
authors.lastname: O'Grady
authors.forename: Matthew
authors.initials: M
authors.lastname: Bates
authors.forename: Nathan
authors.initials: N
authors.lastname: Kapata
authors.forename: Markus
authors.initials: M
authors.lastname: Maeurer
authors.forename: Alimuddin
authors.initials: A
authors.lastname: Zumla
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D001431:Bacteriological Techniques / Q000379:methods; D002986:Clinical Trials as Topic; D003584:Cytological Techniques / Q000379:methods; D003906:Developing Countries; D024881:Drug Resistance, Bacterial; D014943:Global Health; D006040:Goals; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000276:immunology; D058873:Pandemics; D019095:Point-of-Care Systems / Q000639:trends; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D032581:Tuberculosis Vaccines / Q000276:immunology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D000995:Antitubercular Agents; D032581:Tuberculosis Vaccines