title: Association of OX40 and OX40L gene polymorphisms with acute coronary syndrome in a Han Chinese population.
abstract: OX40 and OX40L, members of the tumor necrosis factor receptor superfamily, are costimulatory molecules involved in the activation and proliferation of T lymphocytes. OX40L plays an important role in the process of atherosclerosis, and variants of OX40/OX40L are associated with myocardial infarction in European populations. Our study examined 235 patients with acute coronary syndrome (ACS) and 220 controls and sought to establish whether polymorphisms in OX40/OX40L are associated with atherosclerosis or myocardial infarction in the Han Chinese population. OX40 rs17568A/G, rs2298212A/G, and OX40L rs3850641A/G polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. The results showed that carriers of the G allele of rs17568A/G had a significantly increased risk of ACS (p = 0.023, adjusted odds ratio = 1.72, 95% confidence interval = 1.08-2.75) after adjusting for age, sex, diabetes, hypertension, and lipids. No significant association between rs2298212A/G or rs3850641A/G and the risk of ACS was found in this study. In conclusion, OX40 gene polymorphism may be associated with a risk of ACS in the Han Chinese population, although the association between OX40L polymorphisms and ACS requires further investigation.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR China.
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Ou
authors.initials: O
authors.lastname: Qiang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zeng
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics*; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D053278:OX40 Ligand / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D053262:Receptors, OX40 / Q000235:genetics*
chemical_list: D053278:OX40 Ligand; D053262:Receptors, OX40; C505716:TNFRSF4 protein, human