title: The effect of probiotics on gastric mucosal permeability in humans administered with aspirin.
abstract: OBJECTIVE
  To examine whether a probiotic strain, Lactobacillus gasseri OLL2716 (LG21), can protect the gastric mucosal integrity from aspirin using urinary sucrose excretion (USE) test.
  
  
  METHODS
  In the study using high-dose aspirin, the USE tests were carried out in 29 volunteers before and after LG21 treatment for 4 weeks. In the study using patients undergoing low-dose aspirin therapy, USE tests were performed in 37 subjects who took LG21 for 16 weeks. Stool occult blood was examined by the guaiac method.
  
  
  RESULTS
  In the former study, the elevation in the USE value after aspirin loading significantly decreased after LG21 treatment (Median ± SD; 0.244 ± 0.237 vs. 0.208 ± 0.112%, p = 0.018). In the latter study, the USE value significantly decreased in the period with LG21 treatment (p = 0.033), while no significant difference was found in the period without LG21 (p = 0.113). The number of positive occult blood tests decreased during LG21 treatment.
  
  
  CONCLUSIONS
  The regular ingestion of LG21 may protect the integrity of the gastric mucosal permeability against aspirin.
authors.affiliation: Laboratory for Infectious Diseases, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Akama
authors.forename: Ryo
authors.initials: R
authors.lastname: Nishino
authors.forename: Seiya
authors.initials: S
authors.lastname: Makino
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Kamikaseda
authors.forename: Jun
authors.initials: J
authors.lastname: Nagano
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Koga
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D007778:Lactobacillus / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009780:Occult Blood; D010539:Permeability / Q000187:drug effects; D019936:Probiotics; D013395:Sucrose / Q000652:urine
chemical_list: D013395:Sucrose; D001241:Aspirin