title: Doxorubicin encapsulated nanocarriers for targeted delivery to estrogen responsive breast cancer.
abstract: The encapsulation of anticancer agent in carrier system protects healthy tissues from its cytotoxic effects. In the present study estrogen receptor targeted liposomes encapsulating doxorubicin was designed to enhance the efficiency of delivery of doxorubicin to its destination site. The liposomal formulations showed change in the biodistribution profile. Targeted formulation accumulates more in breast and uterine tissues. ER-targeted formulation of antineoplastic agents could be potentially useful for treatment of ER positive tumors such as breast and uterus.
authors.affiliation: Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar 470003, M.P, India.
authors.forename: Shivani
authors.initials: S
authors.lastname: Rai
authors.forename: Rishi
authors.initials: R
authors.lastname: Paliwal
authors.forename: Suresh P
authors.initials: SP
authors.lastname: Vyas
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D002460:Cell Line; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry*; D011960:Receptors, Estrogen / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D053769:Nanocapsules; D011960:Receptors, Estrogen; D004317:Doxorubicin