title: [Parathyroïd adenoma induced by long term lithium therapy: case report and review].
abstract: We report a case of a parathyroid adenoma during a long term lithium treatment without therapeutic overdose.
  
  
  METHODS
  A 73-years-old woman presented a demonstrative biological syndrome with hypercalcemia, elevated parathormone, normal urinary cyclic AMP, normocalciuria.
  
  
  CONCLUSIONS
  This lithium induced hyperparathyroidism differs from the classic primary hyperparathyroidism with parthyroid adenoma where urinary cyclic AMP excretion is elevated and where there is hypercalciuria. Lithium is blocking the negative feedback of calcium on parathormone secretion and stimulates the growth of parathyroid adenoma. Treatment is surgical and consists in adenoma ablation. Calcemia follow up is indicated in patients with long term lithium therapy
authors.affiliation: Hôpital d'Instruction des Armées Laveran, Service ORL et chirurgie cervico-faciale, 13000 Marseille, France. oliviercoulet@hotmail.com
authors.forename: O
authors.initials: O
authors.lastname: Coulet
authors.forename: M
authors.initials: M
authors.lastname: Achache
authors.forename: R
authors.initials: R
authors.lastname: Derkenne
authors.forename: E
authors.initials: E
authors.lastname: Javelle
authors.forename: P
authors.initials: P
authors.lastname: Le Bougeant
authors.forename: S
authors.initials: S
authors.lastname: Molinier
authors.forename: M
authors.initials: M
authors.lastname: Tomasi
mesh_terms: D000236:Adenoma / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications; D006961:Hyperparathyroidism / Q000139:chemically induced / Q000150:complications; D018020:Lithium Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D010282:Parathyroid Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D011877:Radionuclide Imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D014150:Antipsychotic Agents; D018020:Lithium Compounds