title: Toll-like receptor 2 gene polymorphisms in a Korean population: association with chronic rhinosinusitis.
abstract: OBJECTIVE
  To investigate the role of single-nucleotide polymorphisms (SNPs) in the gene encoding Toll-like receptor (TLR) 2 in Korean patients with chronic rhinosinusitis (CRS) and controls.
  
  
  METHODS
  A case-control study.
  
  
  METHODS
  Subjects (N = 214) were all adults (>20 years old) and were divided into patients with CRS (n = 106) and controls (n = 108). Five SNPs (rs1898830, rs3804099, rs3804100, R677W, and rs5743708) were selected and genotyped in a case-control study with the single-base-pair primer extension (SNaPshot) assay.
  
  
  RESULTS
  The case-control study revealed that 2 SNPs in TLR2, rs3804099 (odds ratio [OR] = 2.88; 95% confidence interval [CI] = 1.17-7.09; P = .022) and rs3804100 (OR = 3.76; 95% CI = 1.42-9.96; P = .008), showed significant differences in minor allele frequency between CRS patients and controls. These 2 SNPs were correlated with CRS risk in Korean patients.
  
  
  CONCLUSIONS
  Two SNPs in TLR2 may be associated with increased risk of CRS in Korean subjects.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Catholic University of Korea, Seoul, Korea.
authors.forename: Chan-Soon
authors.initials: CS
authors.lastname: Park
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Cho
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Park
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D011446:Prospective Studies; D012313:RNA / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology; D012220:Rhinitis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D012852:Sinusitis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D051195:Toll-Like Receptor 2 / Q000097:blood / Q000235:genetics*
chemical_list: D051195:Toll-Like Receptor 2; D012313:RNA