title: Temporal trends in presentation for outpatient HIV medical care 2000-2010: implications for short-term mortality.
abstract: BACKGROUND
  Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications.
  
  
  OBJECTIVE
  To assess temporal trends in late presentation for outpatient HIV medial care as measured by CD4 count <200 cells/mm(3) and the implications on short-term (1-year) mortality.
  
  
  METHODS
  We conducted a cohort study nested in a prospective HIV clinical cohort including patients establishing initial outpatient HIV treatment between 2000-2010. Time series regression analysis evaluated temporal trends in late presentation for care measured by the proportion of patients with a CD4 count <200 cells/mm(3) or an opportunistic infection at enrollment, and also evaluated trends in short-term mortality.
  
  
  METHODS
  Patients establishing initial outpatient HIV treatment between 2000-2010 at an academic HIV clinic.
  
  
  METHODS
  The proportion of patients with a CD4 count <200 cells/mm(3) or an opportunistic infection at initial presentation and short-term (1-year) mortality following clinic enrollment.
  
  
  RESULTS
  Among 1121 patients, 41% had an initial CD4 count <200 cells/mm(3), 25% had an opportunistic infection and 2.4% died within 1-year of their initial visit. Time series regression analysis demonstrated significant reductions in late presentation for HIV care and decreases in short-term mortality with temporal improvement preceding updated CDC HIV testing recommendations.
  
  
  CONCLUSIONS
  We observed a significant decline in the number of patients presenting for outpatient HIV care with advanced disease, particularly in 2006-2010. A significant trend in improved short-term survival among patients establishing HIV care was also observed, likely related to more timely presentation for outpatient care in more recent years.
authors.affiliation: Department of Internal Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, CCB 142, 908 20th Street So, Birmingham, AL 35294-2050, USA.
authors.forename: Paula S
authors.initials: PS
authors.lastname: Seal
authors.forename: David A
authors.initials: DA
authors.lastname: Jackson
authors.forename: Eric
authors.initials: E
authors.lastname: Chamot
authors.forename: James H
authors.initials: JH
authors.lastname: Willig
authors.forename: Christa R
authors.initials: CR
authors.lastname: Nevin
authors.forename: Jeroan J
authors.initials: JJ
authors.lastname: Allison
authors.forename: James L
authors.initials: JL
authors.lastname: Raper
authors.forename: Mirjam C
authors.initials: MC
authors.lastname: Kempf
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Schumacher
authors.forename: Michael S
authors.initials: MS
authors.lastname: Saag
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mugavero
mesh_terms: D000293:Adolescent; D000328:Adult; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D003695:Delivery of Health Care / Q000639:trends*; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000401:mortality*; D006291:Health Policy; D006801:Humans; D008297:Male; D010045:Outpatients / Q000706:statistics & numerical data*; D010342:Patient Acceptance of Health Care; D011446:Prospective Studies; D015144:Southeastern United States; D015996:Survival Rate; D013997:Time Factors