title: What does biologically meaningful mean? A perspective on gene regulatory network validation.
abstract: Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.
authors.affiliation: Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. marian.walhout@umassmed.edu
authors.forename: Albertha J M
authors.initials: AJ
authors.lastname: Walhout
mesh_terms: D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks / Q000235:genetics*; D006801:Humans; D008954:Models, Biological; D012107:Research Design / Q000706:statistics & numerical data; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D014157:Transcription Factors