title: Antiepileptic intranasal Amiloride loaded mucoadhesive nanoemulsion: development and safety assessment.
abstract: Current investigation aimed to develop a novel Amiloride loaded mucoadhesive nanoemulsion formulation for nose-to-brain delivery. Furthermore, nasal irritation study and histopathological examination of the nasal mucosa were also carried out to assess nonirritant nature of the nanoemulsion. The optimized formulation, surface epithelium lining and the granular cellular structure of the nasal mucosa were totally intact, whereas KCl caused major changes in the ultrastructure of mucosa. Amiloride loaded mucoadhesive nanoemulsion formulations are non toxic on nasal mucosa and can be administered by intranasal route for effective treatment of epilepsy.
authors.affiliation: Nanoformulation Research Laboratory, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
authors.forename: Nitin
authors.initials: N
authors.lastname: Jain
authors.forename: Sohail
authors.initials: S
authors.lastname: Akhter
authors.forename: Gaurav K
authors.initials: GK
authors.lastname: Jain
authors.forename: Zeenat I
authors.initials: ZI
authors.lastname: Khan
authors.forename: Roop K
authors.initials: RK
authors.lastname: Khar
authors.forename: Farhan J
authors.initials: FJ
authors.lastname: Ahmad
mesh_terms: D000281:Administration, Intranasal; D000584:Amiloride / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D004655:Emulsions; D006041:Goats; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D009297:Nasal Mucosa / Q000187:drug effects*; D014014:Tissue Adhesives / Q000009:adverse effects / Q000138:chemical synthesis*
chemical_list: D000927:Anticonvulsants; D004655:Emulsions; D053769:Nanocapsules; D014014:Tissue Adhesives; D000584:Amiloride