title: [No association of AhR gene 1661G/A and ARNT gene 567G/C polymorphisms with endometriosis in southern Han Chinese women].
abstract: OBJECTIVE
  To explore the association between the arylhydrocarbon receptor gene (AhR) 1661G/A or arylhydrocarbon nuclear translocatorgene (ARNT) 567G/C polymorphism and endometriosis in southern Han Chinese women.
  
  
  METHODS
  The polymorphisms of AhR gene 1661G/Aand ARNT gene 567G/C in 431 cases of endometriosis and 499 healthy women were genotyped by fluorescence quantitative PCR-based high resolution melting.
  
  
  RESULTS
  The frequencies of genotypes AA, AG, GG and alleles A and G in controls were 12.0%, 41.9%, 46.1%, 33.0% and 67.0%, respectively, which were not significantly different from those in patients with endometriosis (9.7%, 44.6%, 45.7%, 32.0% and 68.0%, respectively). The genotype frequencies of GG, GC, CC and alleles C and G in controls (15.6 %, 51.7%, 32.7%, 58.5%, 41.5%) were not significantly different from those in patients with endometriosis (13.5%, 47.8%, 38.7%, 62.6%, 37.4%), either. And no interaction of AhR 1661G/A and ARNT 567G/C on endometriosis was found.
  
  
  CONCLUSIONS
  No association between AhR 1661G/A and ARNT 567G/C genetic polymorphisms and endometriosis was found in the southern Han Chinese women in this study.
authors.affiliation: Department of Gynecology and Obstetrics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282 P. R. China.
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: WANG
authors.forename: Li-li
authors.initials: LL
authors.lastname: ZONG
authors.forename: Xin
authors.initials: X
authors.lastname: ZHAO
authors.forename: Ting
authors.initials: T
authors.lastname: MAO
authors.forename: Yong-gui
authors.initials: YG
authors.lastname: FU
authors.forename: Jun
authors.initials: J
authors.lastname: ZENG
authors.forename: Xing-qiang
authors.initials: XQ
authors.lastname: RAO
mesh_terms: D000483:Alleles; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000235:genetics*; D002681:China; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics*
chemical_list: D018336:Receptors, Aryl Hydrocarbon; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator