title: [Effect of streptozotocin on the glycemic and lipid profiles and oxidative stress in hamsters].
abstract: OBJECTIVE
  This study evaluated the effects of streptozotocin on glycemic and lipid profiles and oxidative stress status in hamsters.
  
  
  METHODS
  Male Golden Syrian hamsters were divided in diabetic group (D) which received a streptozotocin single injection (STZ - 50 mg/kg), and control group (C) which received a single injection of the vehicle citrate buffer. Animals were euthanized after 10 days of experiment and blood, liver and kidneys were collected.
  
  
  RESULTS
  The diabetic group had higher levels of glucose, triacylglycerols and cholesterol in serum and thiobarbituric acid reactive substances (TBARS) concentration increased in the liver and kidneys. Diabetes induced a significant increase in glutathione concentration in the liver and decreased paraoxonase and superoxide dismutase activities.
  
  
  CONCLUSIONS
  Hamsters provide a novel animal model for diabetes mellitus and oxidative stress, similar to the human syndrome, which may be suitable for the testing of antidiabetic compounds.
authors.affiliation: Núcleo de Pesquisas em Ciências Biológicas, Programa de Pós-graduação em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brasil. maisasilv@yahoo.com.br
authors.forename: Maísa
authors.initials: M
authors.lastname: Silva
authors.forename: Wanderson Geraldo de
authors.initials: WG
authors.lastname: Lima
authors.forename: Marcelo Eustáquio
authors.initials: ME
authors.lastname: Silva
authors.forename: Maria Lucia
authors.initials: ML
authors.lastname: Pedrosa
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008647:Mesocricetus; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D013311:Streptozocin / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D013311:Streptozocin; D013482:Superoxide Dismutase