title: Mitochondrial dysfunction in nonalcoholic steatohepatitis.
abstract: The pathogenesis of nonalcoholic steatohepatitis (NASH) is poorly understood and the mechanisms are still being elucidated. Mitochondrial dysfunction participates at different levels in NASH pathogenesis since it impairs fatty liver homeostasis and induces overproduction of free radicals that in turn trigger lipid peroxidation and cell death. In this article, we review the role of mitochondria in fat metabolism, energy homeostasis and reactive oxygen species production, with a focus on the role of mitochondrial impairment and uncoupling proteins in the pathophysiology of NASH progression. The potential effects of some molecules targeted to mitochondria are also discussed.
authors.affiliation: CURE (Centre for Liver Disease Research and Treatment), Department of Medical and Occupational Sciences, University of Foggia, 70124 Foggia, Italy. g.serviddio@unifg.it
authors.forename: Gaetano
authors.initials: G
authors.lastname: Serviddio
authors.forename: Francesco
authors.initials: F
authors.lastname: Bellanti
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Vendemiale
authors.forename: Emanuele
authors.initials: E
authors.lastname: Altomare
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D004579:Electron Transport; D004734:Energy Metabolism; D005234:Fatty Liver / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism* / Q000648:ultrastructure; D028361:Mitochondrial Diseases / Q000378:metabolism*; D065626:Non-alcoholic Fatty Liver Disease; D018384:Oxidative Stress; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate