title: Clinical question: What is the best approach to managing glucocorticoid-induced osteoporosis?
abstract: Glucocorticoid-induced osteoporosis is common, and the resulting fractures cause significant morbidity and mortality. Rapid bone loss and increased fracture risk occur soon after the initiation of glucocorticoid therapy and are dose dependent. The increase in fracture risk is partly independent of bone mineral density, probably as a result of changes in bone material properties and increased risk of falling. Fracture risk can be assessed using the FRAX algorithm, although risk may be underestimated in patients taking higher doses of glucocorticoids. Because of the rapidity of bone loss and increase in fracture risk after the start of glucocorticoid therapy, primary prevention should be advised in high-risk individuals, for example older women and men, individuals with a previous fracture history and those with low bone mineral density. Bisphosphonates are the front-line choice for the prevention of fracture in the majority of glucocorticoid-treated patients, with teriparatide as a second-line option. Calcium and vitamin D supplements should be co-prescribed unless there is evidence of an adequate dietary calcium intake and vitamin D status.
authors.affiliation: Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. jec1001@cam.ac.uk
authors.forename: Juliet
authors.initials: J
authors.lastname: Compston
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D019468:Disease Management; D005260:Female; D050723:Fractures, Bone / Q000139:chemically induced / Q000517:prevention & control; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced* / Q000150:complications
chemical_list: D050071:Bone Density Conservation Agents; D005938:Glucocorticoids