title: Palladium-catalyzed oxidative coupling of trialkylamines with aryl iodides leading to alkyl aryl ketones.
abstract: A new, simple method for selectively synthesizing alkyl aryl ketones has been developed by palladium-catalyzed oxidative coupling of trialkylamines with aryl iodides. In the presence of PdCl(2)(MeCN)(2), TBAB, and ZnO, a variety of aryl iodides underwent an oxidative coupling reaction with tertiary amines and water to afford the corresponding alkyl aryl ketones in moderate to excellent yields. It is noteworthy that this method is the first example of using trialkylamines as the carbonyl sources for constructing alkyl aryl ketone skeletons.
authors.affiliation: College of Chemistry and Materials Science, Wenzhou University, Wenzhou 325035, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Yao
authors.forename: Chen-Liang
authors.initials: CL
authors.lastname: Deng
authors.forename: Ri-Yuan
authors.initials: RY
authors.lastname: Tang
authors.forename: Xing-Guo
authors.initials: XG
authors.lastname: Zhang
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li
mesh_terms: D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007454:Iodides / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D007454:Iodides; D007659:Ketones; D010165:Palladium