title: Anthropometric, clinical and laboratory comparison of four phenotypes of polycystic ovary syndrome based on Rotterdam criteria.
abstract: OBJECTIVE
  To compare all phenotypes of polycystic ovary syndrome (PCOS) for anthropometrical, hormonal, and metabolic differences according to Rotterdam criteria.
  
  
  METHODS
  Women with PCOS (Rotterdam definition; n = 127) and women without PCOS used as controls (n = 44). There were four phenotypes of PCOS: 56/127 (44.09%) of the patients were polycystic ovaries on ultrasound (PCO) + oligo or anovulation (O) + biochemical and/or clinical hyperandrogenism (HA), 29/127 (22.84%) were HA+O, 24/127 (18.90%) were PCO+O and 18/127 (14.17%) were HA+PCO. And 42/127 (33.07%) patients represented the new phenotypes (PCO+O and HA+PCO). Phenotypical, hormonal and metabolic parameters were compared between the groups.
  
  
  RESULTS
  Waist-to-hip ratio, luteinizing hormone-to-follicle stimulating hormone ratio, testosterone, androstenedione, dehydroepiandrostenedione were lower in women with PCO+O and controls than the other three phenotypes. The highest score regarding hirsutismus was found in the HA+O phenotype and the lowest score in the PCO+O phenotype. Prevalence of metabolic syndrome and degree of insulin resistance in PCO+O phenotype was closer to control subjects than the other three phenotypes.
  
  
  CONCLUSIONS
  Anthropometrical, hormonal, and metabolic differences suggest that PCO+O phenotype is closer to control group than the other PCOS phenotypes.
authors.affiliation: Nenehatun Obstetrics and Gynecology Hospital, Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yilmaz
authors.forename: Unal
authors.initials: U
authors.lastname: Isaoglu
authors.forename: Ilhan Bahri
authors.initials: IB
authors.lastname: Delibas
authors.forename: Sedat
authors.initials: S
authors.lastname: Kadanali
mesh_terms: D000293:Adolescent; D000328:Adult; D000858:Anovulation / Q000209:etiology*; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology*; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology; D056128:Obesity, Abdominal / Q000453:epidemiology* / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D015995:Prevalence; D011446:Prospective Studies; D045165:Testosterone Congeners / Q000097:blood; D014421:Turkey / Q000453:epidemiology; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D006065:Gonadotropins, Pituitary; D045165:Testosterone Congeners