title: Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration.
abstract: Neurodegenerative processes associated with Alzheimer's disease (AD) are accompanied by reactive astrogliosis and microglia activation and a role for chronic inflammation in the brain degeneration of these patients has been suggested. Moreover impaired immune functions in AD brains might also influence the disease's progression. Therefore, it is of interest to further characterized inflammatory molecules in the peripheral blood of patients with AD and its relationship with cognitive decline. A complex picture emerged in this pilot study and IL-8, IFN-gamma, MCP-1 and VEGF levels were increased in AD. Levels of P-selectin and L-selectin were decreased in AD and lowest in AD patients with highest cognitive decline. Our findings suggest that these molecules may induce alterations of endothelial regulation and influence neurodegenerative processes of AD.
authors.affiliation: Department of Human Morphology and Biomedical Sciences "Città Studi", Clinical Pathology Unit, Medical Faculty, University of Milan, Via Luigi MAngiagalli 31, 20133, Milan, Italy. mmcorsi@unimi.it
authors.forename: Massimiliano M
authors.initials: MM
authors.lastname: Corsi
authors.forename: Federico
authors.initials: F
authors.lastname: Licastro
authors.forename: Elisa
authors.initials: E
authors.lastname: Porcellini
authors.forename: Giada
authors.initials: G
authors.lastname: Dogliotti
authors.forename: Emanuela
authors.initials: E
authors.lastname: Galliera
authors.forename: John L
authors.initials: JL
authors.lastname: Lamont
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Innocenzi
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Fitzgerald
mesh_terms: D000544:Alzheimer Disease / Q000097:blood* / Q000473:pathology; D001921:Brain / Q000473:pathology*; D018932:Chemokine CCL2 / Q000097:blood; D003072:Cognition Disorders / Q000097:blood / Q000473:pathology; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D019041:L-Selectin / Q000097:blood*; D008297:Male; D019007:P-Selectin / Q000097:blood*; D010865:Pilot Projects; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D016209:Interleukin-8; D019007:P-Selectin; D042461:Vascular Endothelial Growth Factor A; D019041:L-Selectin; D007371:Interferon-gamma