title: Inflammatory myofibroblastic tumours of the respiratory tract: paediatric case series with varying clinical presentations.
abstract: OBJECTIVE
  To highlight the clinical importance of inflammatory myofibroblastic tumours of the respiratory tract in children, and to present a case series of three children which illustrates this tumour's variable clinical presentation.
  
  
  METHODS
  The series includes: a nine-year-old girl with a diagnosis of juvenile idiopathic arthritis, who presented with finger clubbing and was found to have an inflammatory myofibroblastic tumour in her right upper lobe; a 15-year-old adolescent with a left main stem bronchial inflammatory myofibroblastic tumour, who presented with breathlessness and chest pain; and a 12-year-old girl with a tracheal inflammatory myofibroblastic tumour who presented with stridor. In each case, the tumour was resected surgically.
  
  
  CONCLUSIONS
  Inflammatory myofibroblastic tumour are a rare but clinically important and pathologically distinct lesion of the respiratory tract in children. The cases in this series highlight some of the varied clinical presentations of inflammatory myofibroblastic tumours, and illustrate some of this tumour's different anatomical locations within the paediatric respiratory tract.
authors.affiliation: Department of Respiratory Paediatrics, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK. m.j.brodlie@ncl.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Brodlie
authors.forename: S C
authors.initials: SC
authors.lastname: Barwick
authors.forename: K M
authors.initials: KM
authors.lastname: Wood
authors.forename: M C
authors.initials: MC
authors.lastname: McKean
authors.forename: A
authors.initials: A
authors.lastname: Welch
mesh_terms: D000293:Adolescent; D000077548:Anaplastic Lymphoma Kinase; D018501:Antirheumatic Agents / Q000627:therapeutic use; D018771:Arthralgia / Q000209:etiology; D001171:Arthritis, Juvenile / Q000175:diagnosis; D001999:Bronchoscopy; D002648:Child; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006104:Granuloma, Plasma Cell / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D008727:Methotrexate / Q000627:therapeutic use; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D012008:Recurrence; D012135:Respiratory Sounds / Q000209:etiology; D012140:Respiratory Tract Diseases / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery*; D012878:Skin Neoplasms / Q000601:surgery; D013194:Staining and Labeling; D013848:Thigh / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D018501:Antirheumatic Agents; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases; D008727:Methotrexate