title: Comparison of hypoglycemic activity of fermented mushroom of Inonotus obliquus rich in vanadium and wild-growing I. obliquus.
abstract: The effects of vanadium-enriched and wild Inonotus obliquus were tested on hyperglycemic mice. The vanadium content of the culture medium was 0.6%, reaching a concentration of 3.0 mg/g in the cultured mushroom while in the wild variety is 1/100 of that amount. The toxicity of vanadium at the 3.0 mg/g level is negligible, but its anti-diabetic effects are significantly different to those of the wild variety (p < 0.05). Due to its high bioavailability and low toxicity, vanadium-enriched I. obliquus could be used as a means of vanadium supplementation, with expectation of obtaining higher bioavailability and lower toxicity in animals.
authors.affiliation: School of Traditional Chinese Medicine, Chongqing Medical University, Jieqing Road, Huxi University City, Chongqing, 401331, People's Republic of China.
authors.forename: Yibing
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Haifeng
authors.initials: H
authors.lastname: Cui
authors.forename: Chunyu
authors.initials: C
authors.lastname: Cao
authors.forename: Jianyou
authors.initials: J
authors.lastname: Guo
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
mesh_terms: D000363:Agaricales / Q000737:chemistry* / Q000254:growth & development; D000818:Animals; D001682:Biological Availability; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003470:Culture Media / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D023381:Endpoint Determination; D005260:Female; D005285:Fermentation; D006321:Heart / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D014638:Vanadates / Q000494:pharmacology; D014639:Vanadium / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D003470:Culture Media; D007004:Hypoglycemic Agents; D014639:Vanadium; D014638:Vanadates