title: Oleanane-type triterpene saponins and cassaine-type diterpenoids from Erythrophleum fordii.
abstract: Phytochemical investigation of the EtOH extract of the leaves of Erythrophleum fordii led to the isolation of two oleanane-type triterpene saponins (1-2) and five cassaine-type diterpenoids (4-8) along with one known methyl 3 β-hydroxy-erythrosuamate (3). Their structures were established by extensive NMR, as well as ESI-MS analyses and acid hydrolysis. Biological evaluation of compounds 3- 8 against five human cancer cell lines revealed that compounds 5-7 exhibited potent cytotoxic activity with IC₅₀ values ranging from 1.51 to 8.68 µM.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, and Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Du
authors.forename: Lei
authors.initials: L
authors.lastname: Fang
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Shishan
authors.initials: S
authors.lastname: Yu
authors.forename: Shuanggang
authors.initials: S
authors.lastname: Ma
authors.forename: Haining
authors.initials: H
authors.lastname: Lv
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Yuanyan
authors.initials: Y
authors.lastname: Liu
authors.forename: Jiaming
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
mesh_terms: D045784:Abietanes; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D045784:Abietanes; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D012503:Saponins; C579606:methyl 3beta-hydroxy-erythrosuamate; D009828:Oleanolic Acid; C010696:cassaine