title: Studies on pharmacological properties of mucus and sting venom of Potamotrygon cf. henlei.
abstract: Stingrays from the Potamotrygon cf. henlei species are widely distributed in high numbers throughout the rivers of central-west Brazil, being the source of numerous envenomations occurring in the dry season, posing a serious public health problem even if not properly reported. The accidents usually involve fishermen and bathers, and to date there is no effective treatment for the injured. Considering these facts and limitations of studies aiming at understanding the effects induced by P. cf. henlei envenoming, this study aimed to describe the principal pharmacological and certain biochemical properties of the mucus and sting venom. We found that mucus and sting venom is toxic to mice having nociceptive, edematogenic and proteolysis activities. Our results also indicate that the inflammatory cellular influx observed could be triggered by the venom and mucus. Furthermore the venom and mucus were partially purified by solid-phase extraction tested for antimicrobial activity in which only the mucus presented activity. It could be inferred from the present study that P. cf. henlei venom possesses a diverse mixture of peptides, enzymes and pharmacologically active components.
authors.affiliation: Universidade Federal de Tocantins, Brazil.
authors.forename: Juliane
authors.initials: J
authors.lastname: Monteiro-dos-Santos
authors.forename: Katia
authors.initials: K
authors.lastname: Conceição
authors.forename: Carla Simone
authors.initials: CS
authors.lastname: Seibert
authors.forename: Elineide Eugênio
authors.initials: EE
authors.lastname: Marques
authors.forename: Pedro Ismael
authors.initials: PI
authors.lastname: Silva
authors.forename: Anderson Brito
authors.initials: AB
authors.lastname: Soares
authors.forename: Carla
authors.initials: C
authors.lastname: Lima
authors.forename: Mônica
authors.initials: M
authors.lastname: Lopes-Ferreira
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001938:Brazil; D004487:Edema / Q000139:chemically induced; D018940:Elasmobranchii / Q000378:metabolism; D005260:Female; D005397:Fish Venoms / Q000737:chemistry* / Q000494:pharmacology*; D005400:Fishes, Poisonous / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D051379:Mice; D009093:Mucus / Q000737:chemistry*; D059226:Nociceptive Pain / Q000139:chemically induced
chemical_list: D000890:Anti-Infective Agents; D005397:Fish Venoms