title: Mild decarboxylative activation of malonic acid derivatives by 1,1'-carbonyldiimidazole.
abstract: Malonic acid derivatives undergo unusually mild decarboxylation when treated with N,N'-carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles in an efficient one-pot process.
authors.affiliation: Development Science and Technology, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States.
authors.forename: Danny
authors.initials: D
authors.lastname: Lafrance
authors.forename: Paul
authors.initials: P
authors.lastname: Bowles
authors.forename: Kyle
authors.initials: K
authors.lastname: Leeman
authors.forename: Robert
authors.initials: R
authors.lastname: Rafka
mesh_terms: D003653:Decarboxylation; D004952:Esters / Q000737:chemistry; D005030:Ethylenes / Q000138:chemical synthesis; D007093:Imidazoles / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis; D008314:Malonates / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D004952:Esters; D005030:Ethylenes; D007093:Imidazoles; D007659:Ketones; D008314:Malonates; C006900:N,N-carbonyldiimidazole; C030290:malonic acid; C008223:ketene