title: RsaI polymorphism of the ERβ gene in women with endometriosis.
abstract: We examined the frequency of RsaI polymorphism of the ERβ gene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymorphisms of the ERβ gene and p53 were assessed by PCR and analyzed on 2% agarose gel stained with ethidium bromide. The AG polymorphism genotype frequency in patients with endometriosis was 59.3%, with 40.7% GG. In the control group, the frequency of AG was 6.5%, with 93.5% GG. The frequency of heterozygous AG was nine times higher in patients with endometriosis than in the control group (P < 0.0001).
authors.affiliation: Núcleo de Pesquisas Replicon, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil. ritagenetica@yahoo.com.br
authors.forename: R C P C
authors.initials: RC
authors.lastname: Silva
authors.forename: I R
authors.initials: IR
authors.lastname: Costa
authors.forename: B M
authors.initials: BM
authors.lastname: Bordin
authors.forename: C T X
authors.initials: CT
authors.lastname: Silva
authors.forename: S R
authors.initials: SR
authors.lastname: Souza
authors.forename: C L R
authors.initials: CL
authors.lastname: Júnior
authors.forename: A B
authors.initials: AB
authors.lastname: Frare
authors.forename: K K V O
authors.initials: KK
authors.lastname: Moura
mesh_terms: D000328:Adult; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D004715:Endometriosis / Q000201:enzymology / Q000235:genetics*; D047629:Estrogen Receptor beta / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D047629:Estrogen Receptor beta; D015252:Deoxyribonucleases, Type II Site-Specific; C040158:GTAC-specific type II deoxyribonucleases