title: Inactivated H9N2 avian influenza virus vaccine with gel-primed and mineral oil-boosted regimen could produce improved immune response in broiler breeders.
abstract: The frequent economic losses incurred with H9N2 low pathogenic avian influenza viruses (LPAI) infection have raised serious concerns for the poultry industry. A 1-dose regimen with inactivated H9N2 LPAI vaccine could not prevent vaccinated poultry from becoming infected and from shedding wild viruses. A study was conducted to determine whether a 2-dose regimen of inactivated H9N2 LPAI vaccine could enhance the immunologic response in chickens. Such gel-primed and mineral oil-boosted regimen has produced encouraging results associated with improved immune responses to an H9N2 LPAI. This strategy could be cost effective and helpful for preventing avian influenza virus in the poultry industry.
authors.affiliation: College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul, Republic of Korea.
authors.forename: D-H
authors.initials: DH
authors.lastname: Lee
authors.forename: J-S
authors.initials: JS
authors.lastname: Kwon
authors.forename: H-J
authors.initials: HJ
authors.lastname: Lee
authors.forename: Y-N
authors.initials: YN
authors.lastname: Lee
authors.forename: W
authors.initials: W
authors.lastname: Hur
authors.forename: Y-H
authors.initials: YH
authors.lastname: Hong
authors.forename: J-B
authors.initials: JB
authors.lastname: Lee
authors.forename: S-Y
authors.initials: SY
authors.lastname: Park
authors.forename: I-S
authors.initials: IS
authors.lastname: Choi
authors.forename: C-S
authors.initials: CS
authors.lastname: Song
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002645:Chickens; D005782:Gels; D007115:Immunization Schedule; D007117:Immunization, Secondary; D053127:Influenza A Virus, H9N2 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D005585:Influenza in Birds / Q000517:prevention & control*; D008899:Mineral Oil; D013047:Specific Pathogen-Free Organisms; D015164:Vaccines, Inactivated
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D005782:Gels; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D008899:Mineral Oil