title: Prognostic significance of smac/DIABLO in endometrioid endometrial cancer.
abstract: Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrial pathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examined smac/DIABLO expression in 76 patients with endometrioid endometrial cancers. Presence of smac/DIABLO was quantified by Western blot analysis using nonfixed fresh frozen tissues. Its appearance was found in 55 (72%) of examined tumors. Smac/DIABLO expression significantly correlated with tumor grade (p<0.001). Patients with positive smac/DIABLO tumors had a longer disease-specific survival when compared with those with negative tumors in the 10-year follow-up (p=0.043). The study demonstrated that negative smac/DIABLO expression was a poor prognostic sign.
authors.affiliation: Department of Obstetrics, Gynecology and Obstetrics / Gynecological Care, Medical University of Bialystok, Poland. bdobrzycka@gmail.com
authors.forename: Bozena
authors.initials: B
authors.lastname: Dobrzycka
authors.forename: Slawomir J
authors.initials: SJ
authors.lastname: Terlikowski
authors.forename: Piotr S
authors.initials: PS
authors.lastname: Bernaczyk
authors.forename: Magdalena
authors.initials: M
authors.lastname: Garbowicz
authors.forename: Jacek
authors.initials: J
authors.lastname: Niklinski
authors.forename: Lech
authors.initials: L
authors.lastname: Chyczewski
authors.forename: Marek
authors.initials: M
authors.lastname: Kulikowski
mesh_terms: D000368:Aged; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000378:metabolism*; D011379:Prognosis
chemical_list: D051017:Apoptosis Regulatory Proteins; C412403:DIABLO protein, human; D047908:Intracellular Signaling Peptides and Proteins; D024101:Mitochondrial Proteins