title: Immune response to cancer and its regulation in regional lymph nodes.
abstract: Regional draining lymph nodes (LNs) play a pivotal role in initiating immune responses. However, the presence of metastases may compromise their normal immunological function. Preclinical studies indicate that despite metastases, early tumor-draining LNs are still a rich source of sensitized T cells. Recently, we found that dendritic (DC)-tumor fusion hybrids were capable of stimulating therapeutic T-cell generation in the LN. However, this response is regulated by a tumor-specific suppression mechanism(s). Reversal of these dysfunctions would help the success of immunotherapy.
authors.affiliation: Department of Pediatrics, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
authors.forename: Rongxiu
authors.initials: R
authors.lastname: Zheng
authors.forename: Suyu
authors.initials: S
authors.lastname: Shu
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D006822:Hybrid Cells / Q000276:immunology*; D007165:Immunosuppression Therapy; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D016176:T-Lymphocyte Subsets / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines