title: Myth: necrotizing enterocolitis: probiotics will end the disease, and surgical intervention improves the outcome.
abstract: Necrotizing enterocolitis remains an important contributor to neonatal morbidity and mortality. Recent studies suggest that probiotic supplementation may reduce the risk of the disease in premature infants, and some authors recommend that this approach is ready to be utilized as standard-of-care. Once necrotizing enterocolitis is diagnosed and progresses toward peritonitis or perforation, surgical intervention is thought to improve the outcome, and investigators have suggested that peritoneal drainage is as effective as an exploratory laparotomy. In this chapter, we review the current state of knowledge, and suggest that additional studies are necessary to confirm that probiotics will end this disease, and that surgical intervention may not significantly improve the outcome after diagnosis in these compromised patients.
authors.affiliation: Department of Pediatrics, Northshore University Health System, Evanston, IL 60201, USA. mcaplan@northshore.org
authors.forename: M
authors.initials: M
authors.lastname: Caplan
authors.forename: B
authors.initials: B
authors.lastname: Frost
mesh_terms: D020345:Enterocolitis, Necrotizing / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000601:surgery; D019936:Probiotics / Q000627:therapeutic use*; D016896:Treatment Outcome