title: Determination of atropisomeric configurations of macrocyclic bisbibenzyls by HPLC-CD/UV and quantum chemical calculations.
abstract: Isoriccardin C (1) and riccardin D (2), isolated from the liverwort Reboulia hemisphaerica, were first characterized to be a mixture of two enantiomeric atropisomers by online chiral high-performance liquid chromatography-circular dichroism (HPLC-CD) analysis. Exemplarily for bisbibenzyls of the diarylether-biphenyl type, the absolute atropisomeric configurations of compunds 1 and 2 were determined by the analysis of their CD data coupled with quantum chemical CD calculations.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, China.
authors.forename: Li-Ning
authors.initials: LN
authors.lastname: Wang
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Xie
authors.forename: Xiao-Song
authors.initials: XS
authors.lastname: Zhu
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Fan
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000465:Algorithms; D001713:Biphenyl Compounds / Q000737:chemistry*; D002396:Catechols / Q000737:chemistry* / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D035926:Hepatophyta / Q000737:chemistry*; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000737:chemistry* / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D001713:Biphenyl Compounds; D002396:Catechols; D004365:Drugs, Chinese Herbal; D010647:Phenyl Ethers; D013267:Stilbenes; C459128:isoriccardin C; C547185:riccardin D; C010574:biphenyl