title: Deuterium reveals the dynamics of notch activation.
abstract: Notch activation requires unfolding of a juxtamembrane negative regulatory domain (NRR). Tiyanont et al. (2011) analyzed the dynamics of NRR unfolding in the presence of EGTA. As predicted from the crystal structure and deletion analyses, the lin-Notch repeats unfold first, facilitating access by ADAM proteases. Surprisingly, the heterodimerization domain remains stable.
authors.affiliation: Department of Developmental Biology and Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St. Louis, MO 63110-1095, USA. kopan@wustl.edu
authors.forename: Kopan
authors.initials: K
authors.lastname: Raphael