title: Development of type I gastric carcinoid in patients with chronic atrophic gastritis.
abstract: BACKGROUND
  Long-term observational studies assessing the incidence of type I gastric carcinoid (typeIGC) in patients with chronic atrophic gastritis are few.
  
  
  OBJECTIVE
  To evaluate the occurrence of typeIGC at diagnosis and during follow-up and to identify patient features associated with the presence of typeIGC in a cohort of chronic atrophic gastritis patients.
  
  
  METHODS
  Three hundred and sixty-seven chronic atrophic gastritis patients [245 women, age 54 (18-79) years] underwent regular follow-up by gastroscopy. The incidence of typeIGC was determined in chronic atrophic gastritis patients with at least 2 years of follow-up (n = 214). Baseline clinical and histological features were analysed as factors associated with the presence of typeIGC by univariate analysis.
  
  
  RESULTS
  Type I gastric carcinoid was diagnosed in nine (2.4%) patients at the moment when chronic atrophic gastritis was diagnosed. After 1463 person-years, six patients developed typeIGC with an annual incidence rate (person-year) of 0.4%. Patients with typeIGC had significantly higher levels of gastrin, chromogranin A and more frequently the presence of body polyps and ECL-dysplasia compared with chronic atrophic gastritis patients without typeIGC.
  
  
  CONCLUSIONS
  This cohort study shows that typeIGC is a rare complication in patients with chronic atrophic gastritis, and the presence of body polyps and ECL-dysplasia at gastroscopic/histologic evaluation is strongly associated with the presence of typeIGC.
authors.affiliation: Dipartimento Medico-Chirurgico di Scienze Cliniche, Tecnobiomediche e Medicina Traslazionale, Sant'Andrea Hospital, School of Medicine, University Sapienza, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Vannella
authors.forename: A
authors.initials: A
authors.lastname: Sbrozzi-Vanni
authors.forename: E
authors.initials: E
authors.lastname: Lahner
authors.forename: C
authors.initials: C
authors.lastname: Bordi
authors.forename: E
authors.initials: E
authors.lastname: Pilozzi
authors.forename: V D
authors.initials: VD
authors.lastname: Corleto
authors.forename: J F
authors.initials: JF
authors.lastname: Osborn
authors.forename: G
authors.initials: G
authors.lastname: Delle Fave
authors.forename: B
authors.initials: B
authors.lastname: Annibale
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000145:classification / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005757:Gastritis, Atrophic / Q000473:pathology*; D005773:Gastroscopy / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000145:classification / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*; D055815:Young Adult