title: Rapid determination of enantiomeric excess of α-chiral cyclohexanones using circular dichroism spectroscopy.
abstract: Ketone handedness was discriminated using circular dichroism (CD) spectroscopy by monitoring the metal-to-ligand charge transfer (MLCT) bands of complexes between [Cu(I)((S)-1)(CH(3)CN)(2)]PF(6) and derivatized α-chiral cyclohexanones (4). This method was able to quantify the enantiomeric excess of unknown samples using a calibration curve, giving an absolute error of ±7%. The analysis was fast, allowing potential application of this assay in high-throughput screening (HTS).
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
authors.forename: Diana
authors.initials: D
authors.lastname: Leung
authors.forename: Eric V
authors.initials: EV
authors.lastname: Anslyn
mesh_terms: D002942:Circular Dichroism; D003512:Cyclohexanones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013997:Time Factors
chemical_list: D003512:Cyclohexanones