title: Successful treatment of childhood prolonged refractory status epilepticus with lacosamide.
abstract: Prolonged, refractory status epilepticus is a rare clinical syndrome that is associated with severe morbidity and mortality. Lacosamide is a newly approved medication for treatment of partial onset seizures in adults, which has a novel mechanism of action. Experimental data and recent reports suggest that lacosamide could be effective in status epilepticus. We report a child with prolonged, refractory status epilepticus that persisted for 10 weeks despite treatment with multiple anti-epileptics and anesthetics and was then aborted with lacosamide. This is the first report of the effect of lacosamide in prolonged refractory status epilepticus, and the first report of lacosamide efficacy in status epilepticus in a child.
authors.affiliation: Department of Neurology, University of North Carolina at Chapel Hill, NC 27599-7025, USA. yaelm@neurology.unc.edu
authors.forename: Yael
authors.initials: Y
authors.lastname: Shiloh-Malawsky
authors.forename: Zheng
authors.initials: Z
authors.lastname: Fan
authors.forename: Robert
authors.initials: R
authors.lastname: Greenwood
authors.forename: Michael
authors.initials: M
authors.lastname: Tennison
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D000078334:Lacosamide; D008297:Male; D013226:Status Epilepticus / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide