title: Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action.
abstract: We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT(7)R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.
authors.affiliation: Unidad en Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada (CIFA), University of Navarra, Pamplona, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Berrade
authors.forename: Bárbara
authors.initials: B
authors.lastname: Aisa
authors.forename: María J
authors.initials: MJ
authors.lastname: Ramirez
authors.forename: Silvia
authors.initials: S
authors.lastname: Galiano
authors.forename: Salvatore
authors.initials: S
authors.lastname: Guccione
authors.forename: Lise Román
authors.initials: LR
authors.lastname: Moltzau
authors.forename: Finn Olav
authors.initials: FO
authors.lastname: Levy
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Battaglia
authors.forename: Gemma
authors.initials: G
authors.lastname: Molinaro
authors.forename: Ignacio
authors.initials: I
authors.lastname: Aldana
authors.forename: Antonio
authors.initials: A
authors.lastname: Monge
authors.forename: Silvia
authors.initials: S
authors.lastname: Perez-Silanes
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; C088015:benzothiophene