title: Influence of the consumption pattern of magnesium from magnesium-rich mineral water on magnesium bioavailability.
abstract: It is generally considered that the absorption of Mg is inversely related to the ingested dose. The objective of the present study was to determine if the mode of administration (bolus v. consumption throughout the day) could influence Mg bioavailability from Mg-rich natural mineral water comparing the same nutritional Mg amount (126 mg). Using a 2 d cross-over design, twelve healthy men were asked to drink 1·5 litres Mg-rich mineral water either as 2 × 750 ml or 7 × 212 ml throughout the day. Two stable isotopes ((25)Mg and (26)Mg) were used to label the water in order to distinguish both regimens. Fractional apparent Mg absorption was determined by faecal monitoring and Mg retention was determined by measuring urinary excretion of Mg isotopes. Higher Mg absorption (50·7 (SD 12·7) v. 32·4 (SD 8·1) %; P = 0·0007) and retention (47·5 (SD 12·9) v. 29·0 (SD 7·5) %; P = 0·0008) from Mg-rich mineral water were observed when it was consumed in seven servings compared with larger servings. Thus, regular water consumption throughout the day is an effective way to increase Mg bioavailability from Mg-rich mineral water.
authors.affiliation: Nestlé Research Center, Lausanne, Switzerland. magalie.sabatier@rdls.nestle.com
authors.forename: Magalie
authors.initials: M
authors.lastname: Sabatier
authors.forename: Antoine
authors.initials: A
authors.lastname: Grandvuillemin
authors.forename: Peter
authors.initials: P
authors.lastname: Kastenmayer
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Aeschliman
authors.forename: Florilène
authors.initials: F
authors.lastname: Bouisset
authors.forename: Maurice J
authors.initials: MJ
authors.lastname: Arnaud
authors.forename: Gilles
authors.initials: G
authors.lastname: Dumoulin
authors.forename: Alain
authors.initials: A
authors.lastname: Berthelot
mesh_terms: D000328:Adult; D001682:Biological Availability; D018592:Cross-Over Studies; D004326:Drinking; D005243:Feces / Q000737:chemistry; D005247:Feeding Behavior; D006801:Humans; D007408:Intestinal Absorption; D007554:Isotopes / Q000652:urine; D008274:Magnesium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D008900:Mineral Waters / Q000008:administration & dosage*; D013194:Staining and Labeling; D055815:Young Adult
chemical_list: D007554:Isotopes; D008900:Mineral Waters; D008274:Magnesium