title: Molecular mechanisms of metastasis.
abstract: The mechanism of metastasis is a complex set of events that build upon each other to achieve successful growth in organ sites beyond the primary tumor. The cumulative events for metastasis of different cancers have both common and specific cancer specific events. This review discusses several key factors in different cancers that are responsible in metastasis, which includes epigenetic regulation of tumor suppressor genes, functional activity of tumor-related chemokine receptors, and circulating tumor cells.
authors.affiliation: Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA. hoon@jwci.org
authors.forename: Dave S B
authors.initials: DS
authors.lastname: Hoon
authors.forename: Robert
authors.initials: R
authors.lastname: Ferris
authors.forename: Ryo
authors.initials: R
authors.lastname: Tanaka
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Chong
authors.forename: Catherine
authors.initials: C
authors.lastname: Alix-Panabières
authors.forename: Klaus
authors.initials: K
authors.lastname: Pantel
mesh_terms: D019175:DNA Methylation; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008545:Melanoma / Q000503:physiopathology; D035683:MicroRNAs; D009062:Mouth Neoplasms / Q000503:physiopathology; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D009360:Neoplastic Cells, Circulating / Q000378:metabolism; D019707:Receptors, Chemokine / Q000378:metabolism*; D012878:Skin Neoplasms / Q000503:physiopathology
chemical_list: D035683:MicroRNAs; D019707:Receptors, Chemokine