title: Administrative database research infrequently used validated diagnostic or procedural codes.
abstract: OBJECTIVE
  Administrative database research (ADR) frequently uses codes to identify diagnoses or procedures. The association of these codes with the condition it represents must be measured to gauge misclassification in the study. Measure the proportion of ADR studies using diagnostic or procedural codes that measured or referenced code accuracy.
  
  
  METHODS
  Random sample of 150 MEDLINE-cited ADR studies stratified by year of publication. The proportion of ADR studies using codes to define patient cohorts, exposures, or outcomes that measured or referenced code accuracy and Bayesian estimates for probability of disease given code operating characteristics were measured.
  
  
  RESULTS
  One hundred fifteen ADR studies (76.7% [95% confidence interval (CI), 69.3-82.8]) used codes. Of these studies, only 14 (12.1% [7.3-19.5]) measured or referenced the association of the code with the entity it supposedly represented. This proportion did not vary by year of publication but was significantly higher in journals with greater impact factors. Of five studies reporting code sensitivity and specificity, the estimated probability of code-related condition in code-positive patients was less than 50% in two.
  
  
  CONCLUSIONS
  In ADR, diagnostic and procedural codes are commonly used but infrequently validated. People with a code frequently do not have the condition it represents.
authors.affiliation: Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. carlv@ohri.ca
authors.forename: Carl
authors.initials: C
authors.lastname: van Walraven
authors.forename: Carol
authors.initials: C
authors.lastname: Bennett
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Forster
mesh_terms: D016208:Databases, Factual / Q000592:standards; D006298:Health Services Administration / Q000592:standards; D006302:Health Services Research / Q000379:methods / Q000592:standards*; D006801:Humans; D038801:International Classification of Diseases / Q000592:standards*; D008499:Medical Records / Q000592:standards