title: Stem cells in brain tumorigenesis and their impact on therapy.
abstract: The concept that the genesis of new cells in the adult mammalian brain is negligible has long influenced our perception and understanding of the origin and development of central nervous system (CNS) tumors. The discovery that neurons and glia are produced throughout life from neural stem cells provides new possibilities for candidate precursor cells of CNS neoplasms. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis. As such, opportunities become available to identify new therapeutic strategies.
authors.affiliation: Clinical and Translational Oncology Group, Fundacion Santa Fe de Bogota, Calle 119 No. 7 - 75, Bogota D.C., Colombia. a_cardonaz@yahoo.com
authors.forename: Andrés Felipe
authors.initials: AF
authors.lastname: Cardona
authors.forename: Carmen
authors.initials: C
authors.lastname: Balañá
authors.forename: Diana
authors.initials: D
authors.lastname: Torres
authors.forename: Henry
authors.initials: H
authors.lastname: Becerra
authors.forename: León Darío
authors.initials: LD
authors.lastname: Ortíz
authors.forename: Camilo E
authors.initials: CE
authors.lastname: Fadul
mesh_terms: D000071916:AC133 Antigen; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D005910:Glioma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008322:Mammals; D008527:Medulloblastoma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D058953:Neural Stem Cells / Q000378:metabolism / Q000473:pathology; D055495:Neurogenesis; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D010455:Peptides / Q000378:metabolism; D015398:Signal Transduction; D055153:Stem Cell Niche
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; D010455:Peptides