title: Assessment of ocular pharmacokinetics and safety of Ganciclovir loaded nanoformulations.
abstract: Ganciclovir (GCV) plays an important role in the treatment of ocular viral infections. A high dose results in dose-related toxicity including bone marrow suppression and neutropenia. The aim of the present study was to investigate the comparative potential of different mucoadhesive nano formulations for the topical ocular delivery of Ganciclovir. GCV mucoadhesive Nanoemulsions (GCV-NEs), chitosan nanoparticles (GCV-NPs), GCV mucoadhesive niosomal dispersion (GCV-NDs) were prepared by the reverse-phase evaporation technique. All of the three formulations were evenly round in shape with mean particle size in the range of 23-200 nm. These results indicated the nonirritant and nontoxic nature of the developed formulations. The achieved results may be useful for formulation development of GCV, which could be effective in the treatment of ocular infections by topical instillation.
authors.affiliation: Nanoformulation Research Laboratory, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
authors.forename: Sohail
authors.initials: S
authors.lastname: Akhter
authors.forename: Sushama
authors.initials: S
authors.lastname: Talegaonkar
authors.forename: Zeenat I
authors.initials: ZI
authors.lastname: Khan
authors.forename: Gaurav K
authors.initials: GK
authors.lastname: Jain
authors.forename: Roop K
authors.initials: RK
authors.lastname: Khar
authors.forename: Farhan J
authors.initials: FJ
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects; D001082:Aqueous Humor / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004339:Drug Compounding / Q000379:methods; D015774:Ganciclovir / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics*; D053769:Nanocapsules / Q000009:adverse effects / Q000737:chemistry*; D011817:Rabbits
chemical_list: D000998:Antiviral Agents; D053769:Nanocapsules; D015774:Ganciclovir