title: Topoisomerases, chromatin and transcription termination.
abstract: In eukaryotes transcription is complicated by the DNA being packed in nucleosomes and by supercoils induced by opening of the DNA double helix during elongation. Here we discuss our recent genome-wide work regarding topoisomerases and their role in chromatin remodeling during the transcription cycle and we report a novel function for topoisomerases in transcription termination.
authors.affiliation: Chromatin and Gene Expression; Babraham Institute; Babraham, Cambridge, UK.
authors.forename: Mickaël
authors.initials: M
authors.lastname: Durand-Dubief
authors.forename: J Peter
authors.initials: JP
authors.lastname: Svensson
authors.forename: Jenna
authors.initials: J
authors.lastname: Persson
authors.forename: Karl
authors.initials: K
authors.lastname: Ekwall