title: Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-arylsulfonamide and N-aryl-(4-methoxy-1H-benzo[d]imidazol)-7-sulfonamide analogs of combretastatin A-4.
abstract: Two series of novel benzoimidazole sulfonamides as combretastatin A-4 analogs were synthesized. The cytotoxicities of the title compounds were evaluated against five different cancer cell lines. Among the tested compounds, four compounds displayed cytotoxicities against the HCT8 cell line. Compound 6a has shown the strongest potency against the tested human tumor cell lines with an IC₅₀ value ranging from submicromolar to micromolar level.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Cui
authors.forename: Zhan-Mei
authors.initials: ZM
authors.lastname: Li
authors.forename: Hong-Rui
authors.initials: HR
authors.lastname: Song
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Dong
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Chen
authors.forename: Bai-Ling
authors.initials: BL
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D029765:Combretum / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007093:Imidazoles; C558739:N-aryl-(4-methoxy-1H-benzo(d)imidazol)-7-sulfonamide; D013267:Stilbenes; D013449:Sulfonamides; C058728:fosbretabulin