title: Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster.
abstract: Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.
authors.affiliation: Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia. amoskalev@ib.komisc.ru
authors.forename: Alexey
authors.initials: A
authors.lastname: Moskalev
authors.forename: Mikhail
authors.initials: M
authors.lastname: Shaposhnikov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D008136:Longevity / Q000187:drug effects*; D008297:Male; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D011759:Pyrrolidines / Q000494:pharmacology*; D013859:Thiocarbamates / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D016328:NF-kappa B; D011759:Pyrrolidines; D013859:Thiocarbamates; C020972:pyrrolidine dithiocarbamic acid