title: The biology of immunoglobulin free light chains and kidney injury.
abstract: Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality. All compartments of the kidney may be affected, from the glomerulus to the tubulointerstitium, in a wide variety of disease patterns. Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury.
authors.affiliation: Renal Institute of Birmingham, University Hospital Birmingham, Birmingham, UK. k.basnayake@bham.ac.uk
authors.forename: Kolitha
authors.initials: K
authors.lastname: Basnayake
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Stringer
authors.forename: Colin A
authors.initials: CA
authors.lastname: Hutchison
authors.forename: Paul
authors.initials: P
authors.lastname: Cockwell
mesh_terms: D000818:Animals; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000737:chemistry / Q000378:metabolism*; D007668:Kidney / Q000276:immunology* / Q000473:pathology; D007674:Kidney Diseases / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D010265:Paraproteinemias / Q000150:complications / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D010950:Plasma Cells / Q000276:immunology* / Q000473:pathology; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D007147:Immunoglobulin Light Chains