title: The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment.
abstract: Tumor-associated inflammation is a consequence and a driver of tumorigenesis. Three papers in this issue of Cancer Cell demonstrate the importance of tumor-elicited inflammation in the development and progression of pancreatic ductal adenocarcinoma and esophageal squamous carcinoma. Disruption of tissue homeostasis culminates in activation of STAT3, generating a pro-tumorigenic inflammatory microenvironment.
authors.affiliation: Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Sergei I
authors.initials: SI
authors.lastname: Grivennikov
authors.forename: Michael
authors.initials: M
authors.lastname: Karin