title: Special delivery: targeted therapy with small RNAs.
abstract: Harnessing RNA interference using small RNA-based drugs has great potential to develop drugs designed to knock down expression of any disease-causing gene, thereby greatly expanding the universe of possible drug targets. However, delivering small RNAs into specific tissues and cells is still a hurdle. Here, we review recent progress in overcoming systemic, local and cellular barriers to RNA drug delivery, focusing on strategies for targeted uptake.
authors.affiliation: Laboratory of Nanomedicine, Department of Cell Research and Immunology, GS Wise Faculty of Life Science and Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel. peer@post.tau.ac.il
authors.forename: D
authors.initials: D
authors.lastname: Peer
authors.forename: J
authors.initials: J
authors.lastname: Lieberman
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D015195:Drug Design; D055785:Gene Knockdown Techniques; D018390:Gene Targeting; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000627:therapeutic use*
chemical_list: D034741:RNA, Small Interfering