title: Multiple effects of angiopoietin-2 blockade on tumors.
abstract: In this issue of Cancer Cell, Mazzieri, Pucci, and colleagues describe the marked effects of inhibiting the proangiogenic cytokine, Angiopoietin-2, on tumor angiogenesis and progression in spontaneous tumor models, as well as the proangiogenic functions of TIE2-expressing macrophages.
authors.affiliation: Academic Unit of Inflammation and Tumour Targeting, The University of Sheffield Medical School, Sheffield, UK. claire.lewis@sheffield.ac.uk
authors.forename: Claire E
authors.initials: CE
authors.lastname: Lewis
authors.forename: Napoleone
authors.initials: N
authors.lastname: Ferrara