title: Intracellular proteins displayed on the surface of tumor cells as targets for therapeutic intervention with antibody-related agents.
abstract: The identification of targets which are located intracellularly in normal cells and are exposed on the surface of malignant cells is an issue in the target selection process for the development of anticancer agents. Targets with these characteristics should increase the specificity of intervention and the corresponding therapeutic window. We discuss targets such as heat-shock protein 70 (HSP70) and heat-shock protein 90 (HSP90), glucose-regulated protein 78 (GRP78), actin, cytokeratins, vimentin, nucleolin, nucleosomes, estrogen receptor-alpha variant 36 (ER-α36) and feto-acinar pancreatic protein (FAPP). Involvement of these targets in cellular processes, tumor specificity and tractability with antibody-related agents, are discussed.
authors.affiliation: Roche Diagnostics, Division Pharma, Penzberg, Germany. ulrich.weidle@roche.com
authors.forename: Ulrich H
authors.initials: UH
authors.lastname: Weidle
authors.forename: Daniela
authors.initials: D
authors.lastname: Maisel
authors.forename: Stefan
authors.initials: S
authors.lastname: Klostermann
authors.forename: Christian
authors.initials: C
authors.lastname: Schiller
authors.forename: Elisabeth H
authors.initials: EH
authors.lastname: Weiss
mesh_terms: D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D002462:Cell Membrane / Q000378:metabolism*; D000091342:Endoplasmic Reticulum Chaperone BiP; D047628:Estrogen Receptor alpha / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011506:Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D000906:Antibodies; C506487:ESR1 protein, human; D000091342:Endoplasmic Reticulum Chaperone BiP; D047628:Estrogen Receptor alpha; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins; D011506:Proteins