title: [Study of frequency of TCR-mutant T-helper lymphocytes and level of immunocompetent cells with mFasL apoptosis marker under conditions of ionizing radiation].
abstract: Were investigated the parameters of apoptosis of immune cells, the cell subpopulation composition and frequency of TCR-mutant lymphocytes in the peripheral blood of persons exposed to radiation. Increased number of peripheral mFasL-positive mononuclear cells and the accumulation of TCR-mutant T lymphocytes in a wide range of doses were found in the patients. It is doubtless that the effect of ionizing radiation is accompanied by a simulation of Fas-ligand expression on the surface of peripheral mononuclear cells and modification of the activating signal to apoptosis through the molecule CD4, CD8, CD3. The results can be caused by proapoptotic effect of radiation.
authors.forename: N V
authors.initials: NV
authors.lastname: Beliaeva
mesh_terms: D054508:Acute Radiation Syndrome / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D017209:Apoptosis / Q000276:immunology / Q000528:radiation effects*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D047852:Chernobyl Nuclear Accident; D053222:Fas Ligand Protein / Q000378:metabolism*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000528:radiation effects; D018655:Lymphocyte Count; D009154:Mutation; D011829:Radiation Dosage; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D016176:T-Lymphocyte Subsets; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects*; D014455:Ukraine
chemical_list: D015415:Biomarkers; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D011948:Receptors, Antigen, T-Cell