title: [Regulative mechanism of Chinese herbal medicine on cell signaling pathway in kidney].
abstract: In kidney, the role of cell proliferation, differentiation, apoptosis, inflammatory mediators and cytokines expression is closely related with cell signaling pathways, including tyrosine kinase pathway, transforming growth factor-beta/Smad pathway, Rho/Rho-associated coiled-coil forming protein kinase pathway, phosphoinositol pathway, cyclic nucleotide pathway, nuclear factor kappaB pathway and so on. Some Chinese herbs and their extracts, such as rhubarb and triptolide, as well as some Chinese herbal prescriptions, such as astragalus-angelica mixture and Chailing decoction, not only could ameliorate proliferation, differentiation and apoptosis of renal cell by regulating cell signaling pathways, but also could control target gene transcription, expression and its biological effects through inhibiting the phosphorylation of key signaling molecules.
authors.affiliation: Nanjing Drum Tower Hospital Clinical College of Traditional Chinese Medicine and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China. wachjun2000@163.com
authors.forename: Chaojun
authors.initials: C
authors.lastname: Wang
authors.forename: Yigang
authors.initials: Y
authors.lastname: Wan
authors.forename: Xunyang
authors.initials: X
authors.lastname: Luo
authors.forename: Chenhui
authors.initials: C
authors.lastname: Dou
authors.forename: Qing
authors.initials: Q
authors.lastname: Feng
authors.forename: Qiaojing
authors.initials: Q
authors.lastname: Yan
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal