title: In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements.
abstract: This study reports for the first time in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). The experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it the first known biocompatible and bioinert CPC. These bioinert CPCs might be useful for applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.
authors.affiliation: American Dental Association Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, MD 20899, U.S.A.
authors.forename: Shozo
authors.initials: S
authors.lastname: Takagi
authors.forename: Stan
authors.initials: S
authors.lastname: Frukhtbeyn
authors.forename: Laurence C
authors.initials: LC
authors.lastname: Chow
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Sugawara
authors.forename: Kenji
authors.initials: K
authors.lastname: Fujikawa
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Ogata
authors.forename: Makoto
authors.initials: M
authors.lastname: Hayashi
authors.forename: Binnai
authors.initials: B
authors.lastname: Ogiso