title: A vaccine prepared from a non-pathogenic H5N1 influenza virus strain from the influenza virus library conferred protective immunity to chickens against the challenge with antigenically drifted highly pathogenic avian influenza virus.
abstract: Inactivated influenza virus vaccine prepared from a non-pathogenic influenza virus strain A/duck/Hokkaido/Vac-1/2004 (H5N1) from the virus library conferred protective immunity to chickens against the challenge of antigenically drifted highly pathogenic avian influenza virus (HPAIV), A/whooper swan/Hokkaido/1/2008 (H5N1). The efficacy of the vaccine was comparable to that prepared from genetically modified HPAIV strain deltaRRRRK rg-A/ whooper swan/Mongolia/3/2005 (H5N1), which is more antigenically related to the challenge virus strain, in chickens.
authors.affiliation: Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
authors.forename: Rozanah Asmah Abdul
authors.initials: RA
authors.lastname: Samad
authors.forename: Naoki
authors.initials: N
authors.lastname: Nomura
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Tsuda
authors.forename: Rashid
authors.initials: R
authors.lastname: Manzoor
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kajihara
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tomabechi
authors.forename: Takashi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Norihide
authors.initials: N
authors.lastname: Kokumai
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ohgitani
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Okamatsu
authors.forename: Ayato
authors.initials: A
authors.lastname: Takada
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sakoda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kida
mesh_terms: D000818:Animals; D046090:Anseriformes / Q000276:immunology / Q000821:virology*; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D000918:Antibody Specificity; D002645:Chickens; D003429:Cross Reactions; D004279:DNA, Viral / Q000235:genetics; D004196:Disease Outbreaks / Q000517:prevention & control; D004372:Ducks / Q000276:immunology / Q000821:virology*; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology / Q000502:physiology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D005585:Influenza in Birds / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D008986:Mongolia; D016865:Reassortant Viruses / Q000254:growth & development / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007252:Influenza Vaccines