title: Ocular modifications in a young girl with cryopyrin-associated periodic syndromes responding to interleukin-1 receptor antagonist anakinra.
abstract: An 8-year-old patient with genetically confirmed chronic infantile neurological cutaneous and articular syndrome was treated with interleukin-1 receptor antagonist, anakinra. She initially presented with recurrent episodes of fever, rash, chronic fatigue, frequent headaches, ocular involvement (corneal infiltrate and papillary edema), and permanent increased biologic inflammatory markers. Following treatment with anakinra, all symptoms and inflammation resolved. Ophthalmologic signs normalized. This ophthalmologic description (optic nerve and cornea) has never been illustrated, even if ocular affections are classic in the cryopyrin-associated periodic syndromes.
authors.affiliation: Department of Ophthalmology, APHP, Pitie-Salpetriere Hospital, 75013, Paris, France, celineterradaoph@gmail.com.
authors.forename: Celine
authors.initials: C
authors.lastname: Terrada
authors.forename: Benedicte
authors.initials: B
authors.lastname: Neven
authors.forename: Nathalie
authors.initials: N
authors.lastname: Boddaert
authors.forename: Eric H
authors.initials: EH
authors.lastname: Souied
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Prieur
authors.forename: Pierre
authors.initials: P
authors.lastname: Quartier
authors.forename: Phuc
authors.initials: P
authors.lastname: Lehoang
authors.forename: Bahram
authors.initials: B
authors.lastname: Bodaghi