title: Cognitive and psychosocial development in children with familial hypomagnesaemia.
abstract: OBJECTIVE
  Familial hypomagnesaemia (FH) is a rare genetic condition. Neuromuscular and cardiovascular manifestations are well described, whereas cognitive and psychosocial development of children with FH is generally overlooked.
  
  
  METHODS
  Nine patients with FH were evaluated with psychiatric examination and psychometric tests for cognitive and psychosocial outcome.
  
  
  RESULTS
  Nine children (median age 10.1 yrs, range 3-16.3 yrs, 5 boys and 4 girls) with FH participated. Psychiatric symptoms were hyperactivity, irritability, sleep and speech problems and finger sucking. Common psychiatric diagnoses were Attention Deficit Hyperactivity Disorder, borderline intelligence, mild mental retardation and speech disorders. Parent-rated Child Behavior Checklist and Child Health Questionnaire mean scores were between 0.32-0.79, and 0.4-2.12, respectively; indicating the worsened psychosocial well-being besides considerable psychiatric diagnoses.
  
  
  CONCLUSIONS
  Cognitive and psychosocial outcome in FH may influence morbidity, quality of life and social performance. Neuropsychiatric evaluation should be a routine part of management of children with FH.
authors.affiliation: Marmara University, Department of Pediatric Endocrinology and Diabetes, Istanbul, Turkey.
authors.forename: Tulay
authors.initials: T
authors.lastname: Guran
authors.forename: Ayse
authors.initials: A
authors.lastname: Arman
authors.forename: Teoman
authors.initials: T
authors.lastname: Akcay
authors.forename: Esengul
authors.initials: E
authors.lastname: Kayan
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Atay
authors.forename: Serap
authors.initials: S
authors.lastname: Turan
authors.forename: Abdullah
authors.initials: A
authors.lastname: Bereket
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000150:complications*; D005190:Family; D005260:Female; D006801:Humans; D053565:Hypercalciuria / Q000150:complications* / Q000235:genetics / Q000473:pathology / Q000523:psychology*; D008607:Intellectual Disability / Q000150:complications*; D007361:Intelligence Tests; D008274:Magnesium / Q000097:blood*; D008297:Male; D001523:Mental Disorders / Q000150:complications*; D009397:Nephrocalcinosis / Q000150:complications* / Q000235:genetics / Q000473:pathology / Q000523:psychology*; D010290:Parents; D011569:Psychiatric Status Rating Scales; D015499:Renal Tubular Transport, Inborn Errors / Q000150:complications* / Q000235:genetics / Q000473:pathology / Q000523:psychology*
chemical_list: D008274:Magnesium