title: Association between apolipoprotein E gene polymorphism and the dose for warfarin maintenance.
abstract: OBJECTIVE
  To investigate the association between the apolipoprotein E (apoE) gene polymorphism and the dose for warfarin individual maintenance.
  
  
  METHODS
  The genotypes of 249 patients with warfarin treatment in maintenance doses were determined by PCR/DHPLC assay. The doses for warfarin maintenance were compared among patients with different genotypes.
  
  
  RESULTS
  In the total of 249 patients, the frequencies of 2/ε2, ε2/ε3, ε2/ε4, ε3/ε3, ε3/ε4, ε4/ε4 genotype were 1.20%, 15.66%, 1.80%, 72.29%, 9.24%, 0.80%, respectively; the allele frequencies of ε2, ε3, ε4 were 9.44%, 84.74%, 5.82%, respectively. The warfarin dose of group ε2 (ε2/ε2, ε2/ε3) was (3.24 ± 1.36) mg/d, slightly higher than that of group ε3 (ε3/ε3, 2.91 ± 1.14 mg/d) or group ε4 [ε4/ε4, ε3/ε4, (2.98 ± 1.05) mg/d], but the difference of the warfarin doses among the 3 groups did not reach statistical significance (F=1.848,P>0.05).
  
  
  CONCLUSIONS
  ApoE polymorphism may be not a major genetic factor that influences the individual dose for warfarin maintenance.
authors.affiliation: Department of Laboratory Medicine, Guizhou Provincial People's Hospital, Guiyang 550002, China. hsw713@sina.com
authors.forename: Shengwen
authors.initials: S
authors.lastname: Huang
authors.forename: Baolin
authors.initials: B
authors.lastname: Chen
authors.forename: Daokang
authors.initials: D
authors.lastname: Xiang
authors.forename: Ling
authors.initials: L
authors.lastname: Huang
authors.forename: Bangquan
authors.initials: B
authors.lastname: An
authors.forename: Guifang
authors.initials: G
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage; D001057:Apolipoproteins E / Q000235:genetics*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D006349:Heart Valve Diseases / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014859:Warfarin / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D001057:Apolipoproteins E; D014859:Warfarin