title: Novel benzimidazo[2,1-c][1,4]thiazinone derivatives with potent activity against HSV-1.
abstract: The synthesis of new 2-carboxymethylsulfanylmethyl-1H-benzimidazole and 1,3-dihydro-4H-benzo[4',5']imidazo[2,1-c][1,4]thiazine-4-one-8-carboxylic acid derivatives was investigated. The antiviral activity of compounds 1-14 was tested against the herpes simplex virus 1. Compounds 5 and 14 showed potent activity as they inhibited virus propagation by 94.7% and 91.3% at a dose of 50 µg, respectively. Compounds 5 and 14 showed higher potency than Acyclovir at doses of 20 µg and 50 µg.
authors.affiliation: Chemistry of Natural and Microbial Products Department, National Research Center, Cairo, Egypt. sh12galal@yahoo.com.
authors.forename: Shadia A
authors.initials: SA
authors.lastname: Galal
authors.forename: Shweekar I
authors.initials: SI
authors.lastname: El-Naem
authors.forename: Ahmed O H
authors.initials: AO
authors.lastname: El-Nezhawy
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Ali
authors.forename: Hoda I
authors.initials: HI
authors.lastname: El-Diwani
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018929:Cell Culture Techniques; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D056945:Hep G2 Cells; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D015394:Molecular Structure; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles; D013843:Thiazines