title: Drug discovery in enteroviral infections.
abstract: Enteroviruses (EVs) are common and significant human pathogens in Asia. EV infections can cause a wide spectrum of acute diseases, including CNS complications. These EV infection-related CNS syndromes include acute flaccid paralysis, aseptic meningitis, encephalitis, and even death. Currently, there is no vaccine available for most EVs except for poliovirus; furthermore, there is a lack of clinical antiviral drugs for treating EV-related infections. These shortages reveal the need to develop potent compounds for treating enteroviral infections. This study summarizes the development of drugs for EV-related infections based on molecular targets blocking various steps in the viral replication cycle.
authors.affiliation: Research Center for Emerging Viral Infections, Chang-Gung University, Taiwan.
authors.forename: Tzu-Chun
authors.initials: TC
authors.lastname: Chen
authors.forename: Shin-Ru
authors.initials: SR
authors.lastname: Shih
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D055808:Drug Discovery / Q000379:methods*; D004770:Enterovirus / Q000502:physiology*; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents