title: Solvent-free synthesis of chiral Schiff-base ligands based on ferrocene under microwave irradiation and application to enantioselective nitroaldol (Henry) reaction.
abstract: Chiral Schiff-bases 3a-f based on ferrocene were designed and synthesized using solvent-free methods by mixing ferrocene carbaldehyde 1 with amino alcohols and amines 2a-f under microwave irradiation and classical method for the enantioselective nitroaldol (Henry) reaction. The Schiff-bases were obtained in shorter reaction times and improved yield under microwave irradiation method over classical method. The highest enantioselectivity was observed in ligand 3e (95% ee) when CH(2)Cl(2) was used as solvent.
authors.affiliation: Department of Chemistry, University of Dicle, Diyarbakır, Turkey. gozturk@dicle.edu.tr
authors.forename: Gülşen
authors.initials: G
authors.lastname: Öztürk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Çolak
authors.forename: Nadir
authors.initials: N
authors.lastname: Demirel