title: Critical considerations when planning experimental in vivo studies in dental traumatology.
abstract: In vivo studies are sometimes needed to understand healing processes after trauma. For several reasons, not the least ethical, such studies have to be carefully planned and important considerations have to be taken into account about suitability of the experimental model, sample size and optimizing the accuracy of the analysis. Several manuscripts of in vivo studies are submitted for publication to Dental Traumatology and rejected because of inadequate design, methodology or insufficient documentation of the results. The authors have substantial experience in experimental in vivo studies of tissue healing in dental traumatology and share their knowledge regarding critical considerations when planning experimental in vivo studies.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Resource Centre for Rare Oral Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark. jens.ove.andreasen@rh.regionh.dk
authors.forename: Jens O
authors.initials: JO
authors.lastname: Andreasen
authors.forename: Lars
authors.initials: L
authors.lastname: Andersson
mesh_terms: D032761:Animal Experimentation / Q000941:ethics* / Q000592:standards; D000818:Animals; D003782:Dental Pulp / Q000293:injuries; D023421:Models, Animal; D010513:Periodontal Ligament / Q000293:injuries; D012107:Research Design; D013223:Statistics as Topic; D018677:Tooth Injuries / Q000628:therapy*; D014194:Traumatology / Q000379:methods; D014945:Wound Healing