title: Organocatalyzed enantioselective michael addition of 2-hydroxy-1,4-naphthoquinone to β,γ-unsaturated α-ketophosphonatesθ.
abstract: By employing a cinchonine-based thiourea as catalyst, highly enantioselective Michael addition reactions of 2-hydroxy-1,4-naphthoquinone to β,γ-unsaturated α-ketophosphonates were realized. The reaction afforded the corresponding β-substituted carboxylates in excellent yields with high levels of enantioselectivities (94->99% ee) upon quenching the generated parent structures with DBU and MeOH as a second nucleophile.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Youming
authors.initials: Y
authors.lastname: Wang
authors.forename: Guiping
authors.initials: G
authors.lastname: Wu
authors.forename: Haibin
authors.initials: H
authors.lastname: Song
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Zhou
authors.forename: Chuchi
authors.initials: C
authors.lastname: Tang