title: Eudesmanolides from Taraxacum mongolicum and their inhibitory effects on the production of nitric oxide.
abstract: A new eudesmanolide, 1β,3β-dihydroxy-eudesman-11(13)-en-6α,12-olide (1) was isolated and identified from Taraxacum mongolicum, together with two known compounds, 1β,3β-dihydroxyeudesman-6α,12-olide (2) and loliolide (3). The structure of 1 was established by analysis of its physical and spectroscopic data. 1 was found to have an inhibitory activity on nitric oxide production with an IC(50) of 38.9 μM in activated RAW 264.7 cells.
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Kim
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Choo
authors.forename: In-Ja
authors.initials: IJ
authors.lastname: Ryoo
authors.forename: Jong-Seok
authors.initials: JS
authors.lastname: Ahn
authors.forename: Ick-Dong
authors.initials: ID
authors.lastname: Yoo
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D020128:Inhibitory Concentration 50; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045787:Sesquiterpenes, Eudesmane / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D031205:Taraxacum / Q000737:chemistry*
chemical_list: C559721:1,3-dihydroxyeudesman-11(13)-en-6,12-olide; C559722:1,3-dihydroxyeudesman-6,12-olide; D001572:Benzofurans; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C476916:eudesmanolide; D009569:Nitric Oxide; C030425:loliolide