title: Cell therapy of burns.
abstract: Severe burns remain a life-threatening local and general inflammatory condition often with serious sequelae, despite remarkable progress in their treatment over the past three decades. Cultured epidermal autografts, the first and still most up-to-date cell therapy for burns, plays a key role in that progress, but drawbacks to this need to be reduced by using cultured dermal-epidermal substitutes. This review focuses on what could be, in our view, the next major breakthrough in cell therapy of burns - use of mesenchymal stromal cells (MSCs). After summarizing current knowledge, including our own clinical experience with MSCs in the pioneering field of cell therapy of radiation-induced burns, we discuss the strong rationale supporting potential interest in MSCs in treatment of thermal burns, including limited but promising pre-clinical and clinical data in wound healing and acute inflammatory conditions other than burns. Practical options for future therapeutic applications of MSCs for burns treatment, are finally considered.
authors.affiliation: Burn Treatment Center, Percy Military Hospital, Clamart, France.
authors.forename: T
authors.initials: T
authors.lastname: Leclerc
authors.forename: C
authors.initials: C
authors.lastname: Thepenier
authors.forename: P
authors.initials: P
authors.lastname: Jault
authors.forename: E
authors.initials: E
authors.lastname: Bey
authors.forename: J
authors.initials: J
authors.lastname: Peltzer
authors.forename: M
authors.initials: M
authors.lastname: Trouillas
authors.forename: P
authors.initials: P
authors.lastname: Duhamel
authors.forename: L
authors.initials: L
authors.lastname: Bargues
authors.forename: M
authors.initials: M
authors.lastname: Prat
authors.forename: M
authors.initials: M
authors.lastname: Bonderriter
authors.forename: J-J
authors.initials: JJ
authors.lastname: Lataillade
mesh_terms: D000818:Animals; D002056:Burns / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods / Q000639:trends; D017154:Stromal Cells / Q000637:transplantation