title: Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010.
abstract: Successful treatment of gonorrhoea is the mainstay of public health control. Cefixime and ceftriaxone, highly active third generation cephalosporins, are today the recommended first-line agents in most countries and azithromycin is a second-line agent. However, there is increasing evidence of decreasing susceptibility and emergence of therapeutic failures. In this report two cases of clinical failure to cefixime are described, one of which additionally shows failure to azithromycin and selection of a less susceptible strain during treatment.
authors.affiliation: Sexually Transmitted Bacteria Reference Laboratory, Health Protection Agency, London, United Kingdom. catherine.ison@hpa.org.uk
authors.forename: C A
authors.initials: CA
authors.lastname: Ison
authors.forename: J
authors.initials: J
authors.lastname: Hussey
authors.forename: K N
authors.initials: KN
authors.lastname: Sankar
authors.forename: J
authors.initials: J
authors.lastname: Evans
authors.forename: S
authors.initials: S
authors.lastname: Alexander
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D020682:Cefixime / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D004739:England / Q000453:epidemiology; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification; D012747:Sexual Partners; D017211:Treatment Failure; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin; D020682:Cefixime