title: A new quinoline epoxide from the Australian plant Drummondita calida.
abstract: A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the purification of a new quinoline alkaloid, (2' R)-2',3'-epoxy- N-methylatanine (1), along with eight known natural products, skimmianin, γ-fagarine, maculosidine, evolitrine, dictamnine, pteleine, N-methylatanine, and werneria chromene. Compound 1 displayed 74 % inhibition at 80 µM against a chloroquine -resistant Plasmodium falciparum strain (Dd2).
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Australia.
authors.forename: Xinzhou
authors.initials: X
authors.lastname: Yang
authors.forename: Yunjiang
authors.initials: Y
authors.lastname: Feng
authors.forename: Sandra
authors.initials: S
authors.lastname: Duffy
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: David
authors.initials: D
authors.lastname: Camp
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001315:Australia; D002461:Cell Line, Transformed; D002470:Cell Survival; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D004852:Epoxy Compounds; D010936:Plant Extracts; D011804:Quinolines; C037219:quinoline