title: The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease.
abstract: CD5 is a scavenger-like receptor expressed in association with the antigen-specific receptors on T and B-1a lymphocytes. Recent studies reveal a broader biology for CD5 that includes its role as regulator of cell death and as a receptor for pathogen-associated molecular patterns, in addition to its previously described function as an inhibitory receptor. These findings shed new light into the mechanistic role of CD5 in leukemias and effector cells to exogenous (infectious) or endogenous (autoimmune, tumoral) antigens. The newly identified properties make this receptor a potential candidate to be targeted for therapeutic intervention as well as immune modulation. This review describes the current knowledge on the function of CD5 as an immunomodulatory receptor both in health and in disease.
authors.affiliation: Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Circuito Escolar s/n, Aptdo Postal 70228, Ciudad Universitaria, México, DF 04510, Mexico. soldevi@servidor.unam.mx
authors.forename: Gloria
authors.initials: G
authors.lastname: Soldevila
authors.forename: Chander
authors.initials: C
authors.lastname: Raman
authors.forename: Francisco
authors.initials: F
authors.lastname: Lozano
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018956:CD5 Antigens / Q000276:immunology* / Q000378:metabolism; D002470:Cell Survival; D006801:Humans; D007108:Immune Tolerance; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
chemical_list: D018956:CD5 Antigens