title: Rehabilitating a brain with Alzheimer's: a proposal.
abstract: Alzheimer's disease (AD) is the most common neurodegenerative disorder, originating sporadically in the population aged over 65 years, and advanced age is the principal risk factor leading to AD development. In spite of the large amount of research going on around the globe and all the information now available about AD, there is still no origin or triggering process known so far. Drugs approved for the treatment of AD include tacrine, donepezil, rivastigmine, galantamine, and memantine. These may delay or slow down the degenerative process for a while, but they can neither stop nor reverse its progression. Because that this might be due to a lack of effect of these drugs on degenerating neurons, even when they are able to potentiate the brain in nondegenerative conditions, we propose here an alternative therapy consisting of initial repair of neuronal membranes followed by conventional drug therapies. The rehabilitation of neurons in a degeneration process would enable the drugs to act more effectively on them and improve the effects of treatment in AD patients.
authors.affiliation: Programa de Neurobiología, Universidad Veracruzana, Xalapa, Mexico. garanda@uv.mx
authors.forename: Gonzalo Emiliano
authors.initials: GE
authors.lastname: Aranda-Abreu
authors.forename: María Elena
authors.initials: ME
authors.lastname: Hernández-Aguilar
authors.forename: Jorge
authors.initials: J
authors.lastname: Manzo Denes
authors.forename: Luis Isauro
authors.initials: LI
authors.lastname: García Hernández
authors.forename: Marisol
authors.initials: M
authors.lastname: Herrera Rivero
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000534:rehabilitation*; D002648:Child; D005260:Female; D006801:Humans; D009410:Nerve Degeneration / Q000188:drug therapy / Q000534:rehabilitation; D018697:Nootropic Agents / Q000627:therapeutic use*; D008517:Phytotherapy; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D018697:Nootropic Agents; D014815:Vitamins