title: The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods.
abstract: The Protein Structure Initiative's Structural Biology Knowledgebase (SBKB, URL: http://sbkb.org ) is an open web resource designed to turn the products of the structural genomics and structural biology efforts into knowledge that can be used by the biological community to understand living systems and disease. Here we will present examples on how to use the SBKB to enable biological research. For example, a protein sequence or Protein Data Bank (PDB) structure ID search will provide a list of related protein structures in the PDB, associated biological descriptions (annotations), homology models, structural genomics protein target status, experimental protocols, and the ability to order available DNA clones from the PSI:Biology-Materials Repository. A text search will find publication and technology reports resulting from the PSI's high-throughput research efforts. Web tools that aid in research, including a system that accepts protein structure requests from the community, will also be described. Created in collaboration with the Nature Publishing Group, the Structural Biology Knowledgebase monthly update also provides a research library, editorials about new research advances, news, and an events calendar to present a broader view of structural genomics and structural biology.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Gabanyi
authors.forename: Paul D
authors.initials: PD
authors.lastname: Adams
authors.forename: Konstantin
authors.initials: K
authors.lastname: Arnold
authors.forename: Lorenza
authors.initials: L
authors.lastname: Bordoli
authors.forename: Lester G
authors.initials: LG
authors.lastname: Carter
authors.forename: Judith
authors.initials: J
authors.lastname: Flippen-Andersen
authors.forename: Lida
authors.initials: L
authors.lastname: Gifford
authors.forename: Juergen
authors.initials: J
authors.lastname: Haas
authors.forename: Andrei
authors.initials: A
authors.lastname: Kouranov
authors.forename: William A
authors.initials: WA
authors.lastname: McLaughlin
authors.forename: David I
authors.initials: DI
authors.lastname: Micallef
authors.forename: Wladek
authors.initials: W
authors.lastname: Minor
authors.forename: Raship
authors.initials: R
authors.lastname: Shah
authors.forename: Torsten
authors.initials: T
authors.lastname: Schwede
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Tao
authors.forename: John D
authors.initials: JD
authors.lastname: Westbrook
authors.forename: Matthew
authors.initials: M
authors.lastname: Zimmerman
authors.forename: Helen M
authors.initials: HM
authors.lastname: Berman
mesh_terms: D000595:Amino Acid Sequence; D003628:Database Management Systems; D030562:Databases, Protein; D051188:Knowledge Bases; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009862:Online Systems; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D040901:Proteomics; D014584:User-Computer Interface
chemical_list: D011506:Proteins