title: Critical review of controversial issues in the management of advanced pediatric liver tumors.
abstract: Hepatocellular carcinoma (HCC) and hepatoblastoma (HB) are the most common primary tumors of liver in children. The management of patients with locally advanced, unresectable disease or those with extra-hepatic distant metastases provides substantial challenges to pediatric oncologists, hepatologists, and surgeons. Herein, we critically debate the two sides of three specific controversies: (1) the role of chemotherapy in the treatment of advanced pediatric HCC; (2) the indications for liver transplantation in children with HCC, specifically, the appropriateness of using adult Milan criteria; and (3) the role of liver trasplantation in children with unresectable HB that present with metastatic disease. Pediatr Blood Cancer 2011;56:1013-1018. © 2010 Wiley-Liss, Inc.
authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada. abha.gupta@sickkids.ca
authors.forename: Abha A
authors.initials: AA
authors.lastname: Gupta
authors.forename: J Ted
authors.initials: JT
authors.lastname: Gerstle
authors.forename: Vicky
authors.initials: V
authors.lastname: Ng
authors.forename: Ansely
authors.initials: A
authors.lastname: Wong
authors.forename: Annie
authors.initials: A
authors.lastname: Fecteau
authors.forename: Marcio H
authors.initials: MH
authors.lastname: Malogolowkin
authors.forename: Rebecka L
authors.initials: RL
authors.lastname: Meyers
authors.forename: David
authors.initials: D
authors.lastname: Grant
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Grant
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D016031:Liver Transplantation
chemical_list: D000970:Antineoplastic Agents