title: Laboratory detection and diagnosis of filoviruses.
abstract: Ebola virus (EBOV) and Marburg virus (MARV), belonging to the Filoviridae family, emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates. As high as 50-90% mortality, filoviruses can cause significant threats to public health. However, so far no specific and efficient vaccine has been available, nor have other treatment methods proved to be effective. It is of great importance to detect these pathogens specific, rapidly and sensitively in order to control future filovirus outbreaks. Here, recent progresses in the development of detection and diagnosis methods for EBOV and MARV are summarized.
authors.affiliation: Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Yun-peng
authors.initials: YP
authors.lastname: Wang
authors.forename: Xian-en
authors.initials: XE
authors.lastname: Zhang
authors.forename: Hong-ping
authors.initials: HP
authors.lastname: Wei
mesh_terms: D000818:Animals; D019411:Clinical Laboratory Techniques / Q000295:instrumentation; D029043:Ebolavirus / Q000235:genetics / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D019142:Hemorrhagic Fever, Ebola / Q000175:diagnosis* / Q000662:veterinary* / Q000821:virology; D006801:Humans; D008379:Marburg Virus Disease / Q000175:diagnosis* / Q000821:virology; D029024:Marburgvirus / Q000235:genetics / Q000302:isolation & purification*; D008854:Microscopy, Electron; D016133:Polymerase Chain Reaction