title: Low dose intoxication and a crisis of regulatory models. Chemical mutagens in the Deutsche Forschungsgemeinschaft (DFG), 1963-1973.
abstract: Regulation and the prevention of danger are among the main characteristics of the modern state. However, the idea and the conceptualization of what danger is have changed over time. The genealogy of these changes shows that the history of social change and the history of knowledge are well connected. The 1970s marked the start of a social transformation of Western industrialized societies. This article proposes that this transformation was connected with basic epistemic reconfigurations and that the genealogy of risk played a significant role. This thesis is explored through the example of DFG advisory politics. Beginning in the 1960s, the DFG expert commissions that had been established to make policy and regulation recommendations began to focus more and more on the health effects of environmental pollution. The Commission for Questions of Mutagenicity played a particularly interesting role because its recommendations resulted in the foundation of a research institution run by the DFG, the Central Laboratory for Mutagenicity Testing (CML). The challenges faced by the CML in mutagenic research and testing effected a crisis of the expert-based advisory politics of the Mutagenicity Commission and a fundamental shift in the way scientific (regulatory) knowledge was perceived and valued politically. The pattern of this crisis calls to mind the constellation of the "risk society", but as will be shown, the (re)balancing of science and politics/society presented here is more adequately understood within the framework of political epistemology.
authors.affiliation: Abteilung für Geschichte der Naturwissenschaften mit Schwerpunkt Pharmaziegeschichte, Technische Universität Braunschweig. a.schwerin@tu-bs.de
authors.forename: Alexander
authors.initials: A
authors.lastname: von Schwerin
mesh_terms: D000047:Academies and Institutes / Q000266:history*; D004305:Dose-Response Relationship, Drug; D004787:Environmental Pollution / Q000266:history*; D005860:Germany, West; D049673:History, 20th Century; D006801:Humans; D007221:Industry / Q000266:history*; D009152:Mutagenicity Tests / Q000266:history*; D009153:Mutagens / Q000266:history*; D011041:Poisoning / Q000266:history*; D012958:Societies, Scientific / Q000266:history*
chemical_list: D009153:Mutagens