title: Identification of a tetraene-containing product of the indanomycin biosynthetic pathway.
abstract: The indanomycin biosynthetic gene (idm) cluster was recently identified from Streptomyces antibioticus NRRL 8167. The disruption of one of these genes, idmH, and the increased production of a previously unreported metabolite in this mutant is reported. The structure of this compound was elucidated and was shown to possess a linear tetraene. This metabolite is not a logical biosynthetic intermediate of indanomycin but instead is likely an alternate product of the pathway.
authors.affiliation: School of Chemistry and Biochemistry and the Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
authors.forename: Kathryn R
authors.initials: KR
authors.lastname: Rommel
authors.forename: Chaoxuan
authors.initials: C
authors.lastname: Li
authors.forename: Wendy L
authors.initials: WL
authors.lastname: Kelly
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000378:metabolism; D001407:Bacillus / Q000187:drug effects; D053898:Biosynthetic Pathways / Q000235:genetics; D016984:Enterococcus faecium / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry* / Q000378:metabolism*; D011714:Pyrans / Q000737:chemistry* / Q000378:metabolism*; D013303:Streptomyces antibioticus / Q000235:genetics* / Q000378:metabolism; D011758:Pyrroles
chemical_list: D000900:Anti-Bacterial Agents; D011090:Polyenes; D011714:Pyrans; C114124:indanomycin; D011758:Pyrroles