title: Microsomal triglyceride transfer protein and nonalcoholic fatty liver disease.
abstract: Nonalcoholic fatty liver disease is currently one of the most common forms of liver disease, covering cases from simple steatosis without inflammation, to cases of steatohepatitis and fibrosis, and may lead to liver cirrhosis and hepatocellular carcinoma. The pathophysiology of nonalcoholic fatty liver disease is based on multiple events; changes in the secretion of lipoproteins can lead to steatosis. Liver lipid secretion is mediated by apoB100 and microsomal triglyceride transfer protein (MTP). The pharmacological suppression of MTP is suggested as a possible treatment for hyperlipidemia, although the upregulation of this protein can be a treatment for nonalcoholic steatohepatitis.
authors.affiliation: Department of Gastroenterology, University of Sao Paulo School of Medicine, Av. Dr. Enéas de Carvalho Aguiar n° 255, Instituto Central, # 9159, 05403-000 Sao Paulo, Brazil.
authors.forename: Isabel V A
authors.initials: IV
authors.lastname: Pereira
authors.forename: José T
authors.initials: JT
authors.lastname: Stefano
authors.forename: Cláudia P M S
authors.initials: CP
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D053299:Apolipoprotein B-100 / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D005227:Fatty Acids / Q000096:biosynthesis; D005234:Fatty Liver / Q000378:metabolism / Q000503:physiopathology; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000378:metabolism; D008297:Male; D051379:Mice; D065626:Non-alcoholic Fatty Liver Disease; D011110:Polymorphism, Genetic; D015398:Signal Transduction
chemical_list: D053299:Apolipoprotein B-100; D002352:Carrier Proteins; D005227:Fatty Acids; D007328:Insulin; D008074:Lipoproteins; C106092:microsomal triglyceride transfer protein