title: [Infective endocarditis in patients with congenital heart disease].
abstract: The incidence of infective endocarditis (IE) in patients with congenital heart disease (CHD) is higher than in general population; this is a major problem considering the continuous expansion of such group of patients. Generally the more complex is the congenital heart disease the higher is the risk of IE. The aetiology, clinical features, complications, basis for diagnosis and treatment of IE in CHD patients don't differ from those in acquired cardiac disease; however, right-sided IE is more frequent in CHD patients. Due to the complex anatomy or presence of artificial material in many CHD, the transesophageal echocardiogram is extremely useful although echocardiographic assessment remains difficult. Prognosis is better than in other forms of IE with a mortality rate <10%. Primary prevention is crucial: a good oral-dental hygiene and regular dental review are as important as antibiotic prophylaxis; however this awareness in the CHD population is still not satisfactorily spread due to an educational problem. New IE guidelines from International Cardiology Societies emphasize the role of primary prevention and limit antibiotic prophylaxis to the highest risk patients undergoing the highest risk procedures. This article reviews the main reasons justifying the revision of previous IE guidelines, focuses on criteria to select CHD patients requiring antibiotic prophylaxis and gives information about antibiotic therapy to use.
authors.affiliation: Dipartimento di Cardiologia-Cardiochirurgia Pediatrica e Cardiopatie Congenite dell'Adulto, I.R.C.C.S.-Policlinico San Donato, San Donato Milanese, Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Micheletti
authors.forename: D
authors.initials: D
authors.lastname: Negura
authors.forename: L
authors.initials: L
authors.lastname: Piazza
authors.forename: A
authors.initials: A
authors.lastname: Saracino
authors.forename: G
authors.initials: G
authors.lastname: Butera
authors.forename: C
authors.initials: C
authors.lastname: Arcidiacono
authors.forename: M
authors.initials: M
authors.lastname: Carminati
authors.forename: R
authors.initials: R
authors.lastname: Calaciura
authors.forename: M
authors.initials: M
authors.lastname: Chessa
mesh_terms: D000328:Adult; D019072:Antibiotic Prophylaxis; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D002648:Child; D004697:Endocarditis, Bacterial / Q000209:etiology* / Q000517:prevention & control*; D006330:Heart Defects, Congenital / Q000601:surgery; D006331:Heart Diseases / Q000151:congenital* / Q000601:surgery; D006801:Humans; D017410:Practice Guidelines as Topic; D012307:Risk Factors