title: Novel biodegradable composite wound dressings with controlled release of antibiotics: results in a guinea pig burn model.
abstract: Approximately 70% of all people with severe burns die from related infections despite advances in treatment regimens and the best efforts of nurses and doctors. Silver ion-eluting wound dressings are available for overcoming this problem. However, there are reports of deleterious effects of such dressings due to cellular toxicity that delays the healing process, and the dressing changes needed 1-2 times a day are uncomfortable for the patient and time consuming for the stuff. An alternative concept in wound dressing design that combines the advantages of occlusive dressings with biodegradability and intrinsic topical antibiotic treatment is described herewith. The new composite structure presented in this article is based on a polyglyconate mesh and a porous poly-(dl-lactic-co-glycolic acid) matrix loaded with gentamicin developed to provide controlled release of antibiotics for three weeks. In vivo evaluation of the dressing material in contaminated deep second degree burn wounds in guinea pigs (n=20) demonstrated its ability to accelerate epithelialization by 40% compared to an unloaded format of the material and a conventional dressing material. Wound contraction was reduced significantly, and a better quality scar tissue was formed. The current dressing material exhibits promising results, does not require frequent bandage changes, and offers a potentially valuable and economic approach to treating the life-threatening complication of burn-related infections.
authors.affiliation: Dept. of Biomedical Engineering, Faculty of Engineering, Tel-Aviv University, Tel-Aviv 69978, Israel.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Elsner
authors.forename: Dana
authors.initials: D
authors.lastname: Egozi
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Ullmann
authors.forename: Israela
authors.initials: I
authors.lastname: Berdicevsky
authors.forename: Adaya
authors.initials: A
authors.lastname: Shefy-Peleg
authors.forename: Meital
authors.initials: M
authors.lastname: Zilberman
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000494:pharmacology*; D002056:Burns / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D003286:Contracture / Q000473:pathology; D003692:Delayed-Action Preparations / Q000494:pharmacology; D004195:Disease Models, Animal; D005839:Gentamicins / Q000494:pharmacology*; D006168:Guinea Pigs; D009779:Occlusive Dressings; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D005839:Gentamicins