title: Concepts of connectivity and human epileptic activity.
abstract: This review attempts to place the concept of connectivity from increasingly sophisticated neuroimaging data analysis methodologies within the field of epilepsy research. We introduce the more principled connectivity terminology developed recently in neuroimaging and review some of the key concepts related to the characterization of propagation of epileptic activity using what may be called traditional correlation-based studies based on EEG. We then show how essentially similar methodologies, and more recently models addressing causality, have been used to characterize whole-brain and regional networks using functional MRI data. Following a discussion of our current understanding of the neuronal system aspects of the onset and propagation of epileptic discharges and seizures, we discuss the most advanced and ambitious framework to attempt to fully characterize epileptic networks based on neuroimaging data.
authors.affiliation: Department of Clinical and Experimental Epilepsy, University College London Institute of Neurology London, UK.
authors.forename: Louis
authors.initials: L
authors.lastname: Lemieux
authors.forename: Jean
authors.initials: J
authors.lastname: Daunizeau
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Walker