title: Current use of hepatitis B immune globulin for prevention of de novo hepatitis B in recipients receiving anti-HBc-positive livers.
abstract: Livers from donors positive for antibody against anti-HBc can potentially transmit de novo hepatitis B (DNH) to their recipients. Despite a good outcome, prophylaxis is usually offered to such recipients. There is no consensus on the standard prophylactic regimen and hence prophylaxis varies among different transplant centres. Nonetheless, hepatitis B immune globulin (HBIG) is considered the mainstay of such prophylaxis, either alone or in combination with an oral antiviral treatment. We aim to provide a concise review of the current use of HBIG in prevention of DNH. We also address a few important questions regarding HBIG use.
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, TX, USA, jenjung.pan@uth.tmc.edu.
authors.forename: Jen-Jung
authors.initials: JJ
authors.lastname: Pan
authors.forename: Nirav
authors.initials: N
authors.lastname: Thosani
authors.forename: Victor I
authors.initials: VI
authors.lastname: Machicao
authors.forename: Michael B
authors.initials: MB
authors.lastname: Fallon