title: [Three preparations of compound Chinese herbal medicines for de-adaptation to high altitude: a randomized, placebo-controlled trial].
abstract: BACKGROUND
  With the increase of troops entering the plateau for a variety of missions, the occurrence of de-adaptation increased significantly when the army returned to the plains, however, until now, there has been no effective treatment for de-adaptation to high altitude.
  
  
  OBJECTIVE
  To observe the interventional effects of compound Chinese herbal preparations (Sankang Capsule, Rhodiola Rosea Capsule and Shenqi Pollen Capsule) on de-adaptation to high altitude, and provide scientific evidence for appropriate treatment methods in the army health care for future missions.
  
  
  METHODS
  A randomized, single-blind, placebo-controlled trial design was used. Soldiers of a returning army unit who exhibited de-adaptation response symptoms were selected for observation after participating in earthquake relief at high altitude. A total of 543 soldiers were divided into a Sankang Capsule group, a Rhodiola Rosea Capsule group, a Shenqi Pollen Capsule group and a placebo group for drug intervention and administered with corresponding drugs. The course of treatment was 15 days. A self-evaluation scale for de-adaptation to high altitude was used to measure the signs and symptoms exhibited by the soldiers.
  
  
  METHODS
  Effective rate of signs and symptoms of de-adaptation to high altitude was analyzed after a 15-day treatment and the differences of improvement rate of symptoms between groups were compared to evaluate the efficacy of the drugs.
  
  
  RESULTS
  All three drugs improved the symptoms of de-adaptation to high altitude. Compared with the placebo group, symptoms of de-adaptation to high altitude in the drug-treated groups were remitted (P<0.05). Compared with placebo, Sankang Capsule mainly had well-marked effects on dizziness, fatigue, palpitations, cough, sputum and sore throat (P<0.05); Rhodiola Rosea Capsule significantly reduced the symptoms of fatigue, drowsiness, chest tightness, palpitations, vertigo, lack of attention and memory loss (P<0.05); Shenqi Pollen Capsule significantly reduced the symptoms of dizziness, fatigue, weakness, chest tightness, palpitations, cough, sputum, sore throat, memory loss, unresponsiveness and limb numbness (P<0.05). The symptom improvement rate of Shenqi Pollen Capsule was significantly higher than those of the other two drugs.
  
  
  CONCLUSIONS
  All the three drugs played an evident role in ameliorating symptoms of de-adaptation, and the use of Shenqi Pollen Capsule was more effective than Rhodiola Rosea Capsule and Sankang Capsule.
authors.affiliation: The 68303 Troop Hospital of People's Liberation Army, Wuwei 733004, Gansu Province, China.
authors.forename: Zi-fu
authors.initials: ZF
authors.lastname: Shi
authors.forename: Qi-quan
authors.initials: QQ
authors.lastname: Zhou
authors.forename: Lu
authors.initials: L
authors.lastname: Xiang
authors.forename: San-ding
authors.initials: SD
authors.lastname: Ma
authors.forename: Cheng-jun
authors.initials: CJ
authors.lastname: Yan
authors.forename: Han
authors.initials: H
authors.lastname: Luo
mesh_terms: D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000188:drug therapy*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008517:Phytotherapy; D029771:Rhodiola / Q000737:chemistry*; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C530156:sankang