title: A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-β ligand-receptor binding.
abstract: With single-molecule fluorescence imaging and single-molecule force measurement, we have found that the natural compound Naringenin exerts an inhibition effect on TGF-β ligand-receptor interaction, the initial step of TGF-β signaling.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Key Laboratory of Molecular Nanostructures and Nanotechnology, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Xu
authors.forename: Tie
authors.initials: T
authors.lastname: Xia
authors.forename: Fangjin
authors.initials: F
authors.lastname: Chen
authors.forename: Chunling
authors.initials: C
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Liang
authors.forename: Luhua
authors.initials: L
authors.lastname: Lai
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Fang
mesh_terms: D044950:Flavanones / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D018625:Microscopy, Atomic Force; D057054:Molecular Imaging; D011485:Protein Binding / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D044950:Flavanones; D008024:Ligands; D016212:Transforming Growth Factor beta; C005273:naringenin