title: Fertility preservation in girls and adolescents before chemotherapy and radiation - review of the literature.
abstract: There has been a significant improvement in survival rates over the last decade as a result of advances in the treatment of cancer in children. One of the consequences of chemotherapy may be damage to the ovarian function, which can lead to loss of fertility. Methods of fertility protection have been developed for adult women as a result of advances in reproductive medicine, which make the option of becoming pregnant after surviving cancer realistic. However, only some of the methods can be used in prepubescent girls and adolescents. In addition, a higher number of miscarriages and premature births have been found in women who underwent pelvic radiotherapy during childhood or adolescence and the children were more commonly growth retarded. The effects of cancer treatment on the ovarian function and later fertility should be discussed at the start of treatment.
authors.affiliation: IVF-Department, Women's University Hospital Tuebingen, Germany. barbara.lawrenz@med.uni-tuebingen.de
authors.forename: B
authors.initials: B
authors.lastname: Lawrenz
authors.forename: M
authors.initials: M
authors.lastname: Henes
authors.forename: E
authors.initials: E
authors.lastname: Neunhoeffer
authors.forename: T
authors.initials: T
authors.lastname: Fehm
authors.forename: P
authors.initials: P
authors.lastname: Lang
authors.forename: C P
authors.initials: CP
authors.lastname: Schwarze
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D015925:Cryopreservation; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D007752:Obstetric Labor, Premature / Q000209:etiology; D054315:Oocyte Retrieval; D010052:Ovariectomy; D010053:Ovary / Q000528:radiation effects; D011247:Pregnancy; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control; D050497:Stillbirth; D017741:Survivors
chemical_list: D000970:Antineoplastic Agents; D007987:Gonadotropin-Releasing Hormone