title: [Schoenlein-Henoch purpura as a presentation of squamous cell bronchial carcinoma].
abstract: Schoenlein-Henoch purpura is a systemic vasculitis involving the small vessels. In adults it is rare and is sometimes associated with malignancies such as bronchial carcinoma. We report the case of a 74-year-old male ex smoker who was admitted with necrotic skin lesions associated with a nephrotic syndrome, and was found to have a right upper lobe squamous cell bronchial carcinoma. The renal biopsy led to a diagnosis of IgA nephropathy related to Schoenlein-Henoch purpura. Curative surgical resection of the bronchial carcinoma (ypT2N0M0) was associated with remission of the purpura. The synchronous diagnosis of bronchial carcinoma and Schoenlein-Henoch purpura suggests a potential relationship between these two pathologies. Our observation and other published data strongly suggest a direct link on account of: the synchronous diagnosis, the clinical and biological remission of the Schoenlein-Henoch purpura after curative treatment of the bronchial carcinoma. It is important to recognise both the therapeutic and prognostic significance of this connection.
authors.affiliation: Service des maladies respiratoires, IFR 53, hôpital Maison-Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims, France. aangelier@chu-reims.fr
authors.forename: A-S
authors.initials: AS
authors.lastname: Angelier
authors.forename: L
authors.initials: L
authors.lastname: Petit
authors.forename: A
authors.initials: A
authors.lastname: Wynckel
authors.forename: V
authors.initials: V
authors.lastname: Vuiblet
authors.forename: P
authors.initials: P
authors.lastname: Birembaut
authors.forename: O
authors.initials: O
authors.lastname: Toubas
authors.forename: F
authors.initials: F
authors.lastname: Lebargy
authors.forename: G
authors.initials: G
authors.lastname: Deslee
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D005922:Glomerulonephritis, IGA / Q000209:etiology; D006801:Humans; D011695:IgA Vasculitis / Q000209:etiology*; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D016896:Treatment Outcome