title: [Daptomycin in home hospitalization].
abstract: Outpatient Parenteral Antimicrobial Therapy (OPAT) is widely used in the United States and has advantages for both patients and hospitals. In the last few years, several European countries such as the United Kingdom and Italy have begun to show interest in OPAT, developing this therapeutic modality through distinct healthcare structures. In Spain, the most widely used resources are hospital at home units. Daptomycin is an antibiotic that is administered in a single daily dose, which allows its rapid infusion, and does not require monitoring of plasma levels. These two factors greatly facilitate the ambulatory treatment of severe infections due to Gram-positive microorganisms. The results of clinical trials, case series and post-commercialization registries support the safety and efficacy of the use of daptomycin in OPAT.
authors.affiliation: Unidad de Hospitalización a Domicilio, Hospital General Universitario Gregorio Marañón, Madrid, España. vgonzalez.hgugm@salud.madrid.org
authors.forename: Víctor José
authors.initials: VJ
authors.lastname: González Ramallo
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D017046:Cost Savings; D017576:Daptomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D018575:Home Care Services, Hospital-Based / Q000191:economics; D018718:Home Infusion Therapy / Q000191:economics / Q000706:statistics & numerical data; D006701:Home Nursing / Q000191:economics; D006760:Hospitalization / Q000191:economics; D006801:Humans; D007902:Length of Stay / Q000191:economics / Q000706:statistics & numerical data; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data; D011358:Product Surveillance, Postmarketing / Q000706:statistics & numerical data; D013030:Spain
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin