title: Enhanced translocation of poly(dt)45 through an α-hemolysin nanopore by binding with antibody.
abstract: The translocation time of poly(dT)(45) through an α-hemolysin pore was reduced in the presence of a DNA-binding Fab fragment. The Fab acts as a rudder to steer the DNA into the pore.
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry & Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, PR China.
authors.forename: Yi-Lun
authors.initials: YL
authors.lastname: Ying
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Lee
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Long
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry; D004566:Electrodes; D006460:Hemolysin Proteins / Q000737:chemistry* / Q000378:metabolism; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry* / Q000276:immunology; D058608:Nanopores; D011071:Poly T / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding
chemical_list: D006460:Hemolysin Proteins; D007140:Immunoglobulin Fab Fragments; D011071:Poly T; D004247:DNA