title: Mumps complications and effects of mumps vaccination, England and Wales, 2002-2006.
abstract: We analyzed data from hospital admissions and enhanced mumps surveillance to assess mumps complications during the largest mumps outbreak in England and Wales, 2004-2005, and their association with mumps vaccination. When compared with nonoutbreak periods, the outbreak was associated with a clear increase in hospitalized patients with orchitis, meningitis, and pancreatitis. Routine mumps surveillance and hospital data showed that 6.1% of estimated mumps patients were hospitalized, 4.4% had orchitis, 0.35% meningitis, and 0.33% pancreatitis. Enhanced surveillance data showed 2.9% of mumps patients were hospitalized, 6.1% had orchitis, 0.3% had meningitis, and 0.25% had pancreatitis. Risk was reduced for hospitalization (odds ratio [OR] 0.54, 95% confidence interval [CI] 0.43-0.68), mumps orchitis (OR 0.72, 95% CI 0.56-0.93) and mumps meningitis (OR 0.28, 95% CI 0.14-0.56) when patient had received 1 dose of measles, mumps, and rubella vaccine. The protective effect of vaccination on disease severity is critical in assessing the total effects of current and future mumps control strategies.
authors.affiliation: Health Protection Agency Centre for Infections, London, UK. cheefu.yung@gmail.com
authors.forename: Chee Fu
authors.initials: CF
authors.lastname: Yung
authors.forename: Nick
authors.initials: N
authors.lastname: Andrews
authors.forename: Antoaneta
authors.initials: A
authors.lastname: Bukasa
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Brown
authors.forename: Mary
authors.initials: M
authors.lastname: Ramsay
mesh_terms: D004196:Disease Outbreaks / Q000517:prevention & control*; D004739:England / Q000453:epidemiology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects / Q000276:immunology*; D008587:Meningitis, Viral / Q000209:etiology; D009107:Mumps / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control; D009920:Orchitis / Q000209:etiology; D010195:Pancreatitis / Q000209:etiology; D014611:Vaccination; D014852:Wales / Q000453:epidemiology
chemical_list: D022542:Measles-Mumps-Rubella Vaccine