title: Comparison and correlates of three preference-based health-related quality-of-life measures among overweight and obese women with urinary incontinence.
abstract: OBJECTIVE
  To compare three preference-based health-related quality-of-life (HRQL) measures and examine independent correlates of HRQL among overweight and obese women with urinary incontinence (UI) enrolled in a weight loss intervention trial.
  
  
  METHODS
  Participants completed baseline questionnaires, which included the Health Utilities Index 3 (HUI3) and Medical Outcomes Study Short Form-36 (SF-36). The SF-36 was used to derive SF-6D and estimated Quality of Well-Being (eQWB) scores. Height, weight, medical history, incontinence measures, and level of physical activity also were assessed. The intraclass correlation coefficient (ICC) was computed, and differences in mean scores across HRQL measures were examined. Potential correlates of HUI3, SF-6D, and eQWB scores were evaluated using multivariable generalized linear models.
  
  
  RESULTS
  Mean ± SD scores for the HUI3, SF-6D, and eQWB were 0.81 ± 0.18, 0.75 ± 0.10, and 0.71 ± 0.06, respectively. Significant differences were observed across measures (P < 0.0001), and the overall ICC was 0.36. In multivariable analyses, BMI was negatively associated with HUI3 (P = 0.003) and eQWB (P < 0.001), and UI episode frequency was negatively associated with eQWB (P = 0.015) and SF-6D (P < 0.001).
  
  
  CONCLUSIONS
  Significant differences in mean utilities across the HUI3, SF-6D, and eQWB indicate that these measures do not assess identical dimensions of HRQL. Both BMI and UI episode frequency were related to HRQL in this cohort; however, the magnitude of the relationship depended on the preference-based measure used. These findings highlight the need to consider the method used to generate HRQL values for calculating quality-adjusted life-years in cost-utility analyses, since choice of method may have a substantial impact on the outcome of the analysis.
authors.affiliation: Department of Psychology, Baruch College, CUNY, 55 Lexington Avenue, B8-215, New York, NY 10010, USA. Angela.Pinto@baruch.cuny.edu
authors.forename: Angela Marinilli
authors.initials: AM
authors.lastname: Pinto
authors.forename: Miriam
authors.initials: M
authors.lastname: Kuppermann
authors.forename: Sanae
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Eric
authors.initials: E
authors.lastname: Vittinghoff
authors.forename: Rena R
authors.initials: RR
authors.lastname: Wing
authors.forename: John W
authors.initials: JW
authors.lastname: Kusek
authors.forename: William H
authors.initials: WH
authors.lastname: Herman
authors.forename: Leslee L
authors.initials: LL
authors.lastname: Subak
mesh_terms: D000407:Alabama; D001521:Behavior Therapy / Q000379:methods; D015992:Body Mass Index; D015897:Comorbidity; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000523:psychology* / Q000628:therapy; D019057:Quality-Adjusted Life Years; D015203:Reproducibility of Results; D012237:Rhode Island; D018434:Sickness Impact Profile; D014549:Urinary Incontinence / Q000209:etiology / Q000523:psychology* / Q000628:therapy; D061217:Weight Reduction Programs / Q000379:methods*