title: A polymorphism in the 3'-utr of cyclooxygenase-2 and the risk of gastric cancer.
abstract: A polymorphism within the 3'-UTR 8473T↷C of the cyclooxygenase-2 (COX-2) gene, which plays a role in gastrointestinal cancer development, has been associated with susceptibility to malignant disease. Here, we report on the interaction between the COX-2 3'-UTR T↷C polymorphism and gastric cancer development. DNA from 121 Japanese patients with gastric cancer and 126 age-matched control patients was examined for the COX-2 polymorphism by PCR-RFLP. Odds ratios and the 95% confidence interval (CI) were calculated. Homozygous carriage of the COX-2 8473C allele tended to be associated with an increased risk of gastric cancer compared to the T allele homozygotes of the subjects (OR=3.70; 95% CI, 0.96-14.25). The CC allele was associated with a significant increased risk of diffuse-type gastric cancer (OR=5.29; 95% CI, 1.18-23.70). These findings suggest that the COX-2 3'-UTR 8473T↷C polymorphism could be used as a marker for genetic susceptibility to gastric cancer in Japanese populations.
authors.affiliation: Department of Gastroenterology, Fujita Health University School of Medicine, Aichi 470-1192, Japan. shibat03@fujita-hu.ac.jp.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shibata
authors.forename: Tomiyasu
authors.initials: T
authors.lastname: Arisawa
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Tahara
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hirata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano