title: Inhibitory effect of açaí (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation.
abstract: The palm fruit açaí is known to have potential health benefits due to its antioxidant scavenging capacities. Pretreatment of IgE-sensitized mouse primary cultured mast cells with açaí pulp resulted in the dramatic suppression of antigen-induced degranulation in a dose-dependent manner. Similarly, açaí suppressed IgE-mediated degranulation and transcription of the cytokine genes from a cultured mast cell line of rat basophilic leukemia (RBL)-2H3 cells. Açaí could selectively inhibit FcεRI signaling pathways. Furthermore, the FcεRI-mediated complementary signaling pathway was also suppressed by açaí. These results demonstrate that açaí is a potent inhibitor of IgE-mediated mast cell activation.
authors.affiliation: Laboratory of Biochemistry, Graduate School of Life Science, Kobe Women's University, Kobe, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Horiguchi
authors.forename: Nahoko
authors.initials: N
authors.lastname: Ishiguro
authors.forename: Kazuyasu
authors.initials: K
authors.lastname: Chihara
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ogi
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakashima
authors.forename: Kiyonao
authors.initials: K
authors.lastname: Sada
authors.forename: Naoko
authors.initials: N
authors.lastname: Hori-Tamura
mesh_terms: D000818:Animals; D028023:Arecaceae; D015550:Cell Degranulation; D045744:Cell Line, Tumor; D016207:Cytokines / Q000235:genetics; D005638:Fruit; D015870:Gene Expression; D007073:Immunoglobulin E / Q000276:immunology*; D015471:Leukemia, Basophilic, Acute; D008407:Mast Cells / Q000276:immunology* / Q000502:physiology; D051381:Rats; D017455:Receptors, IgE / Q000276:immunology; D015398:Signal Transduction; D019061:src-Family Kinases / Q000378:metabolism
chemical_list: D016207:Cytokines; C553474:FCER1A protein, rat; D017455:Receptors, IgE; D007073:Immunoglobulin E; C060902:lyn protein-tyrosine kinase; D019061:src-Family Kinases