title: Recombinant antibody libraries and selection technologies.
abstract: Active immunization has benefited human health perhaps more than any other biomedical advancement. Today, passive immunization is profoundly changing the practice of medicine by enabling antibody targeting of toxic, self, and other antigens not conducive to active immunization. Recombinant antibody libraries have contributed greatly to this progress and will continue to do so. The ability to construct and display a variety of antibody libraries, including naive, immune, semi-synthetic, and synthetic ones coupled with rapid screening and selection technologies, is in large measure responsible for the thousands of monoclonal antibody therapeutics in development.
authors.affiliation: Sorrento Therapeutics, Inc., 6042 Cornerstone Court West, San Diego, CA 92121, USA.
authors.forename: Heyue
authors.initials: H
authors.lastname: Zhou
authors.forename: Yan-Liang
authors.initials: YL
authors.lastname: Zhang
authors.forename: Guodi
authors.initials: G
authors.lastname: Lu
authors.forename: Henry
authors.initials: H
authors.lastname: Ji
authors.forename: Charles P
authors.initials: CP
authors.lastname: Rodi
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000235:genetics* / Q000276:immunology* / Q000627:therapeutic use; D015723:Gene Library; D006801:Humans; D007158:Immunologic Techniques; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000906:Antibodies; D011994:Recombinant Proteins