title: Highly enantioselective zinc/BINOL-catalyzed alkynylation of α-ketoimine ester: a new entry to optically active quaternary α-CF3 α-amino acids.
abstract: An effective method for highly enantioselective alkynylation of ketoimine (α-trifluoromethyl ketoimine ester) has been developed via a zinc/BINOL catalyzed process. This protocol provides a useful and facile access to optically active quaternary α-trifluoromethyl α-amino acids and related derivatives of interest in life sciences.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 3, 45 Lingling Road, Shanghai 200032, China.
authors.forename: Gaochao
authors.initials: G
authors.lastname: Huang
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Xingang
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D009284:Naphthols / Q000737:chemistry*; D055620:Optical Phenomena; D013237:Stereoisomerism; D013379:Substrate Specificity; D015032:Zinc / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000596:Amino Acids; C406944:BINOL, naphthol; D007097:Imines; D009284:Naphthols; D015032:Zinc