title: Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.
abstract: BACKGROUND
  Several factors can affect oocyte quality and therefore pregnancy outcome in assisted reproductive technology (ART) cycles. Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin).
  
  
  OBJECTIVE
  In the present study, we aim to evaluate the pregnancy outcomes after the administration of myo-inositol combined with melatonin in women who failed to conceive in previous in vitro fertilization (IVF) cycles due to poor oocyte quality.
  
  
  METHODS
  Forty-six women were treated with 4 g/day myo-inositol and 3 mg/day melatonin (inofolic® and inofolic® Plus, Lo.Lipharma, Rome) for 3 months and then underwent a new IVF cycle.
  
  
  RESULTS
  After treatment, the number of mature oocytes, the fertilization rate, the number of both, total and top-quality embryos transferred were statistically higher compared to the previous IVF cycle, while there was no difference in the number of retrieved oocyte. After treatment, a total of 13 pregnancies occurred, 9 of them were confirmed echographically; four evolved in spontaneous abortion.
  
  
  CONCLUSIONS
  The treatment with myo-inositol and melatonin improves ovarian stimulation protocols and pregnancy outcomes in infertile women with poor oocyte quality.
authors.affiliation: AGUNCO Obstetrics and Gynecology Centre, via G. Cassiani, Rome, 15-00155, Italy. vunfer@gmail.com
authors.forename: Vittorio
authors.initials: V
authors.lastname: Unfer
authors.forename: Emanuela
authors.initials: E
authors.lastname: Raffone
authors.forename: Piero
authors.initials: P
authors.lastname: Rizzo
authors.forename: Silvia
authors.initials: S
authors.lastname: Buffo
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000008:administration & dosage; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007294:Inositol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009865:Oocytes / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D017329:Triptorelin Pamoate / Q000008:administration & dosage
chemical_list: D043373:Follicle Stimulating Hormone, Human; D017329:Triptorelin Pamoate; D007294:Inositol; D008550:Melatonin