title: Hepatic arterial embolization with doxorubicin-loaded superabsorbent polymer microspheres in a rabbit liver tumor model.
abstract: OBJECTIVE
  The pharmacokinetic profile after hepatic arterial embolization with superabsorbent microspheres (QuadraSpheres) loaded with doxorubicin was studied.
  
  
  METHODS
  Rabbits with hepatic VX2 tumors were treated with intra-arterial administration of QuadraSpheres loaded with doxorubicin, or transarterial chemoembolization (TACE) using doxorubicin, Lipiodol and Embospheres, or hepatic arterial infusion (HAI) of doxorubicin. Tumor specimens were evaluated by fluorescence microscopy, and plasma and tumor concentrations of doxorubicin were measured.
  
  
  RESULTS
  The peak plasma concentration of doxorubicin was lower in the QuadraSphere group (309.9 ng/ml) than in the HAI (673.4 ng/ml) or TACE (360.5 ng/ml) groups, suggesting higher tumor retention in the QuadraSphere group. Intratumoral doxorubicin levels declined to negligible levels at 1 and 3 days after treatment, respectively, in the HAI and TACE groups. In the QuadraSphere groups, intratumoral doxorubicin level declined after day 1, but was still detectable at 14 days after treatment and was higher than that in the other groups at 1, 3, and 7 days. Intratumoral doxorubicin fluorescence was detected at all time points in the QuadraSphere group, but only at 1 day after treatment in the TACE group.
  
  
  CONCLUSIONS
  Hepatic arterial administration of doxorubicin-loaded QuadraSpheres enables the sustained release of doxorubicin to hepatic tumors.
authors.affiliation: Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. sgupta@mdanderson.org
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupta
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Wright
authors.forename: Joe
authors.initials: J
authors.lastname: Ensor
authors.forename: Carolyn S
authors.initials: CS
authors.lastname: Van Pelt
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Dixon
authors.forename: Vikas
authors.initials: V
authors.lastname: Kundra
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016461:Chemoembolization, Therapeutic; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers; D004998:Ethiodized Oil / Q000008:administration & dosage; D005780:Gelatin / Q000008:administration & dosage*; D006499:Hepatic Artery; D008111:Liver Function Tests; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology / Q000628:therapy*; D008297:Male; D008856:Microscopy, Fluorescence; D008863:Microspheres; D011108:Polymers; D011817:Rabbits
chemical_list: D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D011108:Polymers; C496735:trisacryl gelatin microspheres; D004998:Ethiodized Oil; D004317:Doxorubicin; D005780:Gelatin