title: Mucocele-like lesions of the breast: a long-term follow-up study.
abstract: BACKGROUND
  Mucocele-like lesions (MLL) of the breast were originally described as benign lesions composed of multiple cysts lined by uniform flat to cuboidal epithelium with extravasated mucin, but subsequent reports described the coexistence of columnar cell lesions (CCL), atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS). Several reports have investigated whether core biopsy can diagnose MLL reliably; however, there is only one report with a long-term follow-up after excision of MLL. We report here 15 surgically excised MLL with a long-term follow-up.
  
  
  RESULTS
  Fifteen lesions diagnosed as MLL from 13 patients who had undergone excisional biopsy between January 2001 and December 2006 were retrieved and followed-up for 24-99 months (median 63.8). Two lesions were accompanied with CCL, 5 with ADH and 3 with low grade DCIS. Four lesions (2 ADH, 2 DCIS) were additionally resected and their histology revealed 2 ADH, one DCIS and one MLL with CCL. Of 4 lesions (3 ADH, one DCIS) without additional resection, one lesion (ADH) relapsed accompanied with DCIS at 37 months after excision.
  
  
  CONCLUSIONS
  MLL were frequently accompanied with CCL, ADH or low grade DCIS. Complete resection may be recommended in case of MLL with ADH or DCIS because of intralesional heterogeneity and the probabilities of relapse.
authors.affiliation: Hakuaikai Sagara Hospital, 3-31, Matsubara, Kagoshima 892-0833, Japan.
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Ohi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Umekita
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Rai
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Sagara
authors.forename: Shinichi
authors.initials: S
authors.lastname: Baba
authors.forename: Shugo
authors.initials: S
authors.lastname: Tamada
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Sagara
authors.forename: Taeko
authors.initials: T
authors.lastname: Kukita
authors.forename: Takako
authors.initials: T
authors.lastname: Yoshioka
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Hatanaka
authors.forename: Yoshiatsu
authors.initials: Y
authors.lastname: Sagara
authors.forename: Akihide
authors.initials: A
authors.lastname: Tanimoto
mesh_terms: D000328:Adult; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000601:surgery; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D009078:Mucocele / Q000175:diagnosis* / Q000601:surgery; D009364:Neoplasm Recurrence, Local