title: Ultramicroscopy of bone at oral implant sites: a comparison of ED and control patients. Part 1-defining the protocol.
abstract: OBJECTIVE
  The aim of this study was to develop a protocol to analyze the microstructure of mandibular and maxillary bone in association with implant placement in ectodermal dysplasia (ED) and anodontia conditions compared to patients not suffering from such conditions.
  
  
  METHODS
  This study was not additionally invasive, since the bone harvesting was completed at the time and site of implant placement. Bone samples were allocated into two groups (ED and control patients) and specified by the site of bone harvesting. Microcomputed tomography (micro-CT) analysis at 5-Μm resolution was conducted on each bone sample. Computer analysis applying specialized CT analysis and software allowed evaluation of the three-dimensional microstructure of alveolar and basal bone samples for comparison of structural parameters.
  
  
  RESULTS
  Ten bone samples (five alveolar and five basal) were harvested. Preliminary data confirmed the structural features and significant differences between alveolar and basal bone. Basal bone had greater absolute and percent bone volume, greater bone surface, and a lower trabecular bone pattern factor than alveolar bone.
  
  
  CONCLUSIONS
  Preliminary data were derived from bone harvested from both the maxilla and mandible of control patients, while bone samples from ED patients were harvested from only the anterior mandible. Further bone samples will provide more data on whether broader areas of bone harvesting, age, or sex affect the quality and quantity of the bone and influence implant treatment outcomes.
authors.affiliation: The University of Sydney Westmead Centre for Oral Health, Westmead, Australia.
authors.forename: Patcharawan
authors.initials: P
authors.lastname: Silthampitag
authors.forename: Iven
authors.initials: I
authors.lastname: Klineberg
authors.forename: Allan S
authors.initials: AS
authors.lastname: Jones
authors.forename: Bruce
authors.initials: B
authors.lastname: Austin
authors.forename: Kwan Yat
authors.initials: KY
authors.lastname: Zee
authors.forename: Christine
authors.initials: C
authors.lastname: Wallace
authors.forename: Stefan
authors.initials: S
authors.lastname: Scholz
authors.forename: Anthony
authors.initials: A
authors.lastname: Naim
authors.forename: Khaled
authors.initials: K
authors.lastname: Zoud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000539:Alveolar Process / Q000000981:diagnostic imaging; D000848:Anodontia / Q000000981:diagnostic imaging; D015519:Bone Density / Q000502:physiology; D015921:Dental Implants; D004476:Ectodermal Dysplasia / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging*; D008437:Maxilla / Q000000981:diagnostic imaging*; D008875:Middle Aged; D009911:Oral Hygiene Index; D009929:Organ Size; D010512:Periodontal Index; D012984:Software; D013499:Surface Properties; D014076:Tooth Diseases / Q000145:classification; D014716:Vertical Dimension; D055114:X-Ray Microtomography / Q000379:methods*; D055815:Young Adult
chemical_list: D015921:Dental Implants