title: The functional role of long non-coding RNA in human carcinomas.
abstract: Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.
authors.affiliation: British Columbia Cancer Agency Research Centre, Vancouver, Canada. egibb@bccrc.ca
authors.forename: Ewan A
authors.initials: EA
authors.lastname: Gibb
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Brown
authors.forename: Wan L
authors.initials: WL
authors.lastname: Lam
mesh_terms: D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated