title: Adverse effects of TiO2 and ZnO nanoparticles in soil nematode, Caenorhabditis elegans.
abstract: During the last decade, advancement of nanotechnology has revolutionized various fields such as electronics, optics, materials science as well as architecture, and medicine. However, their health and environmental impact is not fully understood. TiO2 and ZnO nanoparticles (NPs), which are abundantly used for commercial purposes, pose a great risk to environment. In this context, we examined the adverse effects of TiO2 and ZnO NPs of < 25 nm and < 100 nm sizes to nematode Caenorhabditis elegans. < 25 nm TiO2 and ZnO NPs showed LC50 of 77 mg/L and 0.32 mg/L respectively, while < 100 nm TiO2 NPs were non-toxic and LC50 of 2 mg/L was obtained for < 100 nm ZnO NPs. Our studies indicate that in both cases, smaller particle sizes are more toxic than larger NPs and ZnO NPs are more toxic than TiO2 NPs. Further, we observed low LC50 values for ZnO NPs, probably reflecting the sensitivity of C. elegans as a model for eco-toxicity studies of NPs.
authors.affiliation: Nanomaterial Toxicology Group, Indian Institute of Toxicology Research (CSIR), P.O. Box 80, Mahatma Gandhi Marg, Lucknow 226001, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Khare
authors.forename: Madhavi
authors.initials: M
authors.lastname: Sonane
authors.forename: Rakesh
authors.initials: R
authors.lastname: Pandey
authors.forename: Shakir
authors.initials: S
authors.lastname: Ali
authors.forename: Kailash C
authors.initials: KC
authors.lastname: Gupta
authors.forename: Aruna
authors.initials: A
authors.lastname: Satish
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000502:physiology*; D007928:Lethal Dose 50; D053758:Nanoparticles / Q000633:toxicity*; D013534:Survival; D016019:Survival Analysis; D015996:Survival Rate; D014025:Titanium / Q000633:toxicity*; D015034:Zinc Oxide / Q000633:toxicity*
chemical_list: C009495:titanium dioxide; D014025:Titanium; D015034:Zinc Oxide