title: Severe bleeding after antithrombotic therapy in urosepsis masquerading as myocardial infarction.
abstract: Cardiac dysfunction is common in patients with severe sepsis and septic shock. We present a 71-year-old woman with Escherichia coli urosepsis and sepsis-induced myocardial injury masquerading as non-ST elevated myocardial ischemia. Spontaneous psoas hematoma requiring blood transfusion and intracranial hemorrhage developed after antiplatelet and anticoagulant therapies, even in therapeutic doses. The patient was managed conservatively and recovered well with minor residual hemiparesis. Bleeding complications are a common risk of antithrombotic therapy. It is therefore crucial to weigh the impact of efficacy against safety. Old age, female gender, renal insufficiency and sepsis character increased the risk of bleeding in this patient. A misinterpretation of elevated cardiac troponin I may give rise to a diagnostic dilemma and cause unnecessary morbidity.
authors.affiliation: Emergency Department, Taipei Veterans General Hospital, Taiwan.
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Cheng
authors.forename: Hsin-Chin
authors.initials: HC
authors.lastname: Shih
authors.forename: Chorng-Kuang
authors.initials: CK
authors.lastname: How
authors.forename: Yang-Ying
authors.initials: YY
authors.lastname: Lin
authors.forename: David
authors.initials: D
authors.lastname: Hung-Tsang Yen
authors.forename: Mu-Shun
authors.initials: MS
authors.lastname: Huang
mesh_terms: D000368:Aged; D000906:Antibodies / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006406:Hematoma / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D018805:Sepsis / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D028761:Withholding Treatment
chemical_list: D000906:Antibodies; D005343:Fibrinolytic Agents