title: Combination of synthetic and natural products as pesticides (CSYNAP): a new class of antifungal agents.
abstract: In the present communication some dehydrated dialdol products such as 1, 5 - Diphenyl pent - 1, 4 - diene - 3 - one (A1); 1, 9 - Diphenylnon - 1, 3, 6, 8 - tetraene - 5 - one (A2); 1, 5 - di (2 - hydroxyphenyl) pent - 1, 4 - diene - 3 - one (A3); 1, 5 - difuran pent - 1, 4 - diene - 3 - one (A4); 1, 5 - di [4 - bis (N, Ndimethyl) phenyl] pent - 1, 4 - diene - 3 - one (A5) were screened for their antifungal activity. To reduce their adverse effect on the environment, for the first time, we have attempted to screen the antifungal activity of these synthetic compounds in conjunction with selected natural products. The natural products that were used in our study include Nicotine tobaccum and Neem oil (Azadirachta indica). A set of 15 samples was tested against highly pathogenic and of extensive host range fungi Sclerotium rolfsii, Rhizactonia bataticola, Fusarium udum. The filter paper disc assay to monitor antifungal effect revealed significant and interesting results. We found that the use of the combination of natural and synthetic pesticides is more effective and environmentally healthy compared to just synthetic chemicals and/or less available natural products. These results obtained from the combined use of natural and synthetic chemicals lead us to suggest to a new class of less toxic but more effective pesticides. We call it group as CSYNAP, i. e. Combination of SYnthetic and NAtural products as Pesticides.
authors.affiliation: Department of Applied Chemistry, Delhi College of Engineering, Bawana Road, Delhi- 110042, India.
authors.forename: Archna
authors.initials: A
authors.lastname: Rani
authors.forename: Sapna
authors.initials: S
authors.lastname: Jain
authors.forename: Prem
authors.initials: P
authors.lastname: Dureja
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Tripathi
authors.forename: Kamalendra
authors.initials: K
authors.lastname: Singh
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects; D005989:Glycerides / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012232:Rhizoctonia / Q000187:drug effects; D013729:Terpenes / Q000494:pharmacology; D014026:Nicotiana / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D001688:Biological Products; D005989:Glycerides; D013729:Terpenes; C002443:neem oil