title: [Which analgesic after dextropropoxyphene withdrawal? A survey in a sample of general practitioners in southwest of France].
abstract: Following the announcement of the future withdrawal in Europe of drugs containing dextropropoxyphene-paracetamol (DXP-P), we performed a postal survey in a randomly selected sample of 350 general practitioners (GP) from the Midi-Pyrénées area (2.6 million inhabitants) in order to investigate which drug (s) they are willing to prescribe in anticipation of the announced withdrawal. Most of GP prescribed DXP-P in acute and chronic pain. In acute pain, GP would switch to codeine-paracetamol (59.1%) or tramadol alone or associated with paracetamol (79%), whereas they would switch to high dose paracetamol (54.7%) and tramadol alone or associated with paracetamol (74.6%) in chronic pain. Switching to other level 2 analgesic drugs after the withdrawal of dextropropoxyphene should be closely monitored because the safety profile of other drugs.
authors.affiliation: Département Universitaire de Médecine Générale de Midi-Pyrénées, Université de Toulouse, Toulouse, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Bismuth
authors.forename: Eng Laing
authors.initials: EL
authors.lastname: Leng
authors.forename: Stéphane
authors.initials: S
authors.lastname: Oustric
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montastruc
authors.forename: Maryse
authors.initials: M
authors.lastname: Lapeyre-Mestre
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D059787:Acute Pain / Q000188:drug therapy; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000701:Analgesics, Opioid / Q000009:adverse effects*; D059350:Chronic Pain / Q000188:drug therapy; D003061:Codeine / Q000627:therapeutic use; D011431:Dextropropoxyphene / Q000009:adverse effects*; D004338:Drug Combinations; D004363:Drug Utilization; D019538:Health Care Surveys; D006801:Humans; D059408:Pain Management / Q000639:trends*; D057051:Product Recalls and Withdrawals; D011795:Surveys and Questionnaires; D014147:Tramadol / Q000627:therapeutic use
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D004338:Drug Combinations; D000082:Acetaminophen; C011800:acetaminophen, dextropropoxyphene, drug combination; D014147:Tramadol; D011431:Dextropropoxyphene; D003061:Codeine