title: [Multiparametric magnetic resonance imaging of the prostate - technique and clinical applications].
abstract: Multiparametric magnetic resonance imaging (MRI) includes 1 H magnetic resonance spectroscopy, diffusion-weighted imaging, and dynamic contrast-enhanced MRI. These new MRI techniques are increasingly being used to supplement conventional T 2 and T 1-weighted MR sequences in prostate imaging. The first part of this review outlines each of these techniques, the most important diagnostic parameters, and the pathophysiological background. The characteristic features of prostate cancer and noncancerous prostate tissue as depicted with each of the three techniques are presented. The second, clinical part outlines the diagnostic applications of the three MRI techniques for the early detection and localization of prostate cancer, staging, and the identification of recurrent cancer and discusses the most recent publications in this field. The review concludes with a look at emerging clinical applications such as the evaluation of biological aggressiveness and tumor volume.
authors.affiliation: Radiologie CCM, Charité - Universitätsmedizin Berlin. tobias.franiel@charite.de
authors.forename: T
authors.initials: T
authors.lastname: Franiel
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D042241:Early Diagnosis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology* / Q000503:physiopathology; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D012016:Reference Values; D012680:Sensitivity and Specificity; D047368:Tumor Burden / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media; D017430:Prostate-Specific Antigen