title: Organic chemistry and immunochemical strategies in the design of potent carbohydrate-based vaccines.
abstract: A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting specific competent immune cell receptors. Amongst several potential vaccine candidates dedicated against diseases, this short report will focused on those most advance and state of the art organic chemistry involved therein. One case has led to the first example of a commercial vaccine entirely prepared from a synthetic carbohydrate antigen against infections caused by the Gram-negative bacteria Haemophilus influenza type b responsible for pneumonia and acute bacterial meningitis in infants. Other commendable examples will illustrate the immunochemical strategies engaged in the development of anticancer carbohydrate-based vaccines.
authors.affiliation: PharmaQAM-Department of Chemistry Université du Québec à Montréal P.O. Box 8888, Succ. Centre-ville, Montreal Quebec, Canada H3C 3P8. roy.rene@uqam.ca
authors.forename: René
authors.initials: R
authors.lastname: Roy
authors.forename: Tze Chieh
authors.initials: TC
authors.lastname: Shiao
mesh_terms: D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology; D002625:Chemistry, Organic; D015195:Drug Design; D007120:Immunochemistry; D018448:Models, Immunological; D008969:Molecular Sequence Data; D014612:Vaccines / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology
chemical_list: D002241:Carbohydrates; D014612:Vaccines