title: [Induction of amnesia evoked by memory reconsolidation disruption with glutamate or serotonin receptor antagonists depends on protein synthesis activation].
abstract: Effects of DNQX (ionotropic AMPA/cainate glutamate receptor antagonist) and metiotepin (serotonin receptor antagonist) and cycloheximide (protein synthesis inhibitor) on long-term memory reconsolidation processes were studied in snail Helix lucorum with definite type of food aversion conditioned reflex. DNQX or cycloheximide injected immediately before reminding disrupt retrieval of the food aversion 24 hours after conditioning, and repeated trials of learning with the same food as at initial trials did not form the food aversion 2 weeks later. Metiotepin + reminding also discrupt recalling of food aversion 24 hours after conditioning, while food aversion was repaired after repeated trials 2 weeks later. Simultaneous injections of DNQX + cycloheximide or metiotepin + cycloheximide immediately before reminding do not discrupt the food aversion. We suggest that unrecovered and recovered forms of amnesia induced by AMPA/cainate glutamate receptor antagonists or serotonin receptor antagonist, respectively, need specific protein molecules de novo.
authors.forename: V P
authors.initials: VP
authors.lastname: Nikitin
authors.forename: S V
authors.initials: SV
authors.lastname: Solntseva
mesh_terms: D000647:Amnesia / Q000139:chemically induced* / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000009:adverse effects* / Q000494:pharmacology; D006372:Helix, Snails / Q000378:metabolism*; D008568:Memory / Q000187:drug effects*; D014176:Protein Biosynthesis / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D011810:Quinoxalines / Q000009:adverse effects* / Q000494:pharmacology; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*; D011985:Receptors, Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D011500:Protein Synthesis Inhibitors; D011810:Quinoxalines; D018091:Receptors, AMPA; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C056723:FG 9041; D003513:Cycloheximide