title: Association of polymorphisms and haplotypes of the NBN gene with laryngeal cancer and multiple primary tumors of the head and neck.
abstract: BACKGROUND
  We investigated whether genetic polymorphisms of the DNA repair gene NBN are associated with head and neck cancer risk.
  
  
  METHODS
  We analyzed 6 polymorphisms in 175 patients with a single laryngeal tumor, 104 with multiple primary tumors but 1 malignancy (primary/second) localized in the larynx, 60 patients with multiple primary tumors localized in the head or neck, and 275 controls.
  
  
  RESULTS
  Although frequencies of single nucleotide polymorphism alleles did not show marked differences, we found significant differences in haplotype frequencies between patients and controls. Haplotypes GGTTAA and ACCCGT were associated with an increased risk of laryngeal cancer (p < .0001, p = .002) and haplotypes GGCCAA and GCCCGT with an increased risk of multiple primary tumors (p < .0001, p = .039).
  
  
  CONCLUSIONS
  Specific haplotypes of the NBN gene may be related to increased susceptibility to laryngeal cancer and second primary tumors localized in the head and neck.
authors.affiliation: Department of Molecular Pathology, Institute of Human Genetics of the Polish Academy of Sciences, Strzeszyńska 32 St., 60-479 Poznań, Poland. iwziol@man.poznan.pl
authors.forename: Iwona
authors.initials: I
authors.lastname: Ziółkowska-Suchanek
authors.forename: Maria
authors.initials: M
authors.lastname: Mosor
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wierzbicka
authors.forename: Marta
authors.initials: M
authors.lastname: Fichna
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Rydzanicz
authors.forename: Jerzy
authors.initials: J
authors.lastname: Nowak
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D018797:Cell Cycle Proteins; C112156:NBN protein, human; D009687:Nuclear Proteins