title: Class II radical hysterectomy for stage I-IIA cervix cancer: prognostic factors associated to recurrence and survival in a northeast Brazil experience.
abstract: BACKGROUND
  The main aim of this study was describe the author's experience with class II radical hysterectomy and pelvic lymphadenectomy to treat stage I-IIA cervix cancer and reexamine some prognostic factors associated with disease recurrence and patient survival in this data from northeast Brazil.
  
  
  METHODS
  A cross-sectional study was carried out on patients treated at our Centers from January 2001 to December 2008. Statistical analyses were performed using conventional methods.
  
  
  RESULTS
  Eighty-eight patients were selected to analysis. Over the 7.3-year follow-up, 80 (91%) patients were alive and 8 (9%) disease recurrences were observed. Overall 1-, 2-, and 5-year patients survival was 96.5%, 95.3%, and 84%, respectively. Recurrence was associated to tumor size ≥1 cm (P = 0.021) and compromised vaginal margin (P = 0.020). Lower survivals were associated to tumor size ≥1 cm (P = 0.038), compromised vaginal margin (P < 0.001), and lymph node metastasis (P = 0.024). Postoperative complications (n = 11) included wound infection (5.7%), partial wound dehiscence (3.4%), and bladder atony (3.4%).
  
  
  CONCLUSIONS
  Class II radical hysterectomy has provided appropriated disease control of cervix cancer with low morbidity in our experience. Furthermore, tumor size and compromised vaginal margin were significantly associated to recurrence. These factors and lymph node metastasis were also associated to lower 5-year survival according to our analysis.
authors.affiliation: HCP-Hospital de Câncer de Pernambuco, Recife, PE, Brazil.
authors.forename: Artur Lício Rocha
authors.initials: AL
authors.lastname: Bezerra
authors.forename: Mário Rino
authors.initials: MR
authors.lastname: Martins
authors.forename: Simone Maria Muniz da Silva
authors.initials: SM
authors.lastname: Bezerra
authors.forename: José Natal
authors.initials: JN
authors.lastname: Figueiroa
authors.forename: Thales Paulo
authors.initials: TP
authors.lastname: Batista
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D001938:Brazil; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D010386:Pelvic Neoplasms / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery