title: The development of neural synchrony and large-scale cortical networks during adolescence: relevance for the pathophysiology of schizophrenia and neurodevelopmental hypothesis.
abstract: Recent data from developmental cognitive neuroscience highlight the profound changes in the organization and function of cortical networks during the transition from adolescence to adulthood. While previous studies have focused on the development of gray and white matter, recent evidence suggests that brain maturation during adolescence extends to fundamental changes in the properties of cortical circuits that in turn promote the precise temporal coding of neural activity. In the current article, we will highlight modifications in the amplitude and synchrony of neural oscillations during adolescence that may be crucial for the emergence of cognitive deficits and psychotic symptoms in schizophrenia. Specifically, we will suggest that schizophrenia is associated with impaired parameters of synchronous oscillations that undergo changes during late brain maturation, suggesting an important role of adolescent brain development for the understanding, treatment, and prevention of the disorder.
authors.affiliation: Department of Neurophysiology, Max-Planck Institute for Brain Research, Frankfurt am Main, Germany. peter.uhlhaas@brain.mpg.de
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Uhlhaas
authors.forename: Wolf
authors.initials: W
authors.lastname: Singer
mesh_terms: D000293:Adolescent; D041923:Adolescent Development; D017668:Age of Onset; D001921:Brain / Q000254:growth & development* / Q000503:physiopathology*; D003423:Critical Period, Psychological; D006801:Humans; D009415:Nerve Net / Q000254:growth & development / Q000503:physiopathology*; D009434:Neural Pathways / Q000254:growth & development / Q000503:physiopathology*; D012559:Schizophrenia / Q000503:physiopathology*