title: Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: UCMS causes relaxation impairment to ACh.
abstract: Major depression is an independent risk factor for the development of cardiovascular disease. This impact of depression on vascular function seems to be mediated by the endothelial dysfunction, defined as an impairment of endothelium-dependent vasorelaxation, which represents a reliable predictor of atherosclerosis and has been regularly found to be associated with depression. This study aimed at investigating aortic vascular reactivity in mice submitted to the unpredictable chronic mild stress (UCMS) procedure, a reliable model of depression. The results confirm the effectiveness of the UCMS procedure to induce neuroendocrine, physical and behavioral depression-like alterations as well as a significant decrease of acetylcholine-induced vasorelaxation without any effect on phenylephrine-induced vasoconstriction. In this study, we reveal an altered vascular reactivity in an animal model of depression, demonstrating an endothelial dysfunction reminiscent to the one found in depressed patients.
authors.affiliation: INSERM U930 and, Université François Rabelais de Tours, 37200 Tours, France. Isingrini.elsa@voila.fr
authors.forename: Elsa
authors.initials: E
authors.lastname: Isingrini
authors.forename: Alexandre
authors.initials: A
authors.lastname: Surget
authors.forename: Catherine
authors.initials: C
authors.lastname: Belzung
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Freslon
authors.forename: Jefferson
authors.initials: J
authors.lastname: Frisbee
authors.forename: James
authors.initials: J
authors.lastname: O'Donnell
authors.forename: Vincent
authors.initials: V
authors.lastname: Camus
authors.forename: Alexandre
authors.initials: A
authors.lastname: d'Audiffret
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000503:physiopathology*; D001522:Behavior, Animal; D003345:Corticosterone / Q000097:blood; D003863:Depression / Q000097:blood / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010656:Phenylephrine / Q000494:pharmacology; D013315:Stress, Psychological / Q000097:blood / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
chemical_list: D010656:Phenylephrine; D000109:Acetylcholine; D003345:Corticosterone