title: [Regulatory role of heparin compounds with low molecular blood ligands in plasma and thrombocyte hemostasis].
abstract: Analysis of the literature and our own research on the physiological effects of complex compounds of heparin with low molecular ligands (amino acids, regulatory peptides) is presented. It is proved that anticoagulative effects in blood flow were conditioned by the interaction of heparin with glioproline, immunopeptides, and other low molecular substances with formation of complex compounds. The presence of structural regions of binding of heparin and other components is established. It is indicated that in the blood of animals heparin complexes with low molecular ligands possess protective anticoagulative and antithrombotic effects. We made an attempt to reveal the possible mechanism of anticoagulative-fibrinolytic and antithrombotic action of complex compounds of heparin in the organism.
authors.forename: L A
authors.initials: LA
authors.lastname: Liapina
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Obergan
authors.forename: V E
authors.initials: VE
authors.lastname: Pastorova
mesh_terms: D000596:Amino Acids / Q000097:blood* / Q000737:chemistry; D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D006493:Heparin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D008024:Ligands; D008970:Molecular Weight; D010455:Peptides / Q000097:blood* / Q000737:chemistry; D015539:Platelet Activation / Q000187:drug effects* / Q000502:physiology; D011485:Protein Binding
chemical_list: D000596:Amino Acids; D000925:Anticoagulants; D008024:Ligands; D010455:Peptides; D006493:Heparin