title: Gold(I)-catalyzed intermolecular hydroarylation of allenes with nucleophilic arenes: scope and limitations.
abstract: The addition of nucleophilic methoxyarenes to allenes proceeds at room temperature in dichloromethane with a catalytic amount of phosphite-gold(I) precatalyst and silver additive. The addition is regioselective for the allene terminus, and generates E-allylation products without the need for prefunctionalization of the synthons as organometallics or allyl bromides. Coordinating heteroaromatics and sterically hindered allenes do not participate in the reaction.
authors.affiliation: Caudill Laboratories, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Tarselli
authors.forename: Ann
authors.initials: A
authors.lastname: Liu
authors.forename: Michel R
authors.initials: MR
authors.lastname: Gagné