title: Ion channels in autoimmune neurodegeneration.
abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only partially effective so far, ion channel modulation as a future strategy was brought into focus. Here, we review the status quo concerning recent findings from ion channel research in MS and its animal model, experimental autoimmune encephalomyelitis.
authors.affiliation: Institute of Physiology-Neuropathophysiology, Westfälische Wilhelms-University, Münster, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Ehling
authors.forename: Stefan
authors.initials: S
authors.lastname: Bittner
authors.forename: Thomas
authors.initials: T
authors.lastname: Budde
authors.forename: Heinz
authors.initials: H
authors.lastname: Wiendl
authors.forename: Sven G
authors.initials: SG
authors.lastname: Meuth
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D056747:Immunomodulation; D007473:Ion Channels / Q000378:metabolism*; D009410:Nerve Degeneration / Q000150:complications / Q000276:immunology / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: D007473:Ion Channels