title: Total hip replacement in a patient with acquired haemophilia A: a case report and literature review.
abstract: Acquired hemophilia A (AHA) is a very rare disease of idiopathic type, or secondary to neoplastic disease, the use of some drugs, or pregnancy. Owing to the rarity of the disease, no comparative clinical studies are currently available on the results of different intraoperative and postoperative pharmacological preventive strategies in arthroplasty surgery. We report the first case of a total hip replacement procedure for a fracture of the femoral neck performed in a patient affected by AHA. Treatment with recombinant factor VII was administered, at the dosage of 170 μg/kg preoperatively and continued postoperatively at 120-90 μg/kg every 2-6 h. The outcome described supports the use of the protocol adopted, demonstrating that the treatment duration was well adapted to this highly invasive surgical procedure.
authors.affiliation: Department of Clinical Methodology and Surgical Techniques, Orthopedics Section, Faculty of Medicine and Surgery of University of Bari, General Hospital, Piazza Giulio Cesare 11, Bari, Italy. angelanotarnicola@yahoo.it
authors.forename: Angela
authors.initials: A
authors.lastname: Notarnicola
authors.forename: Vito
authors.initials: V
authors.lastname: Pesce
authors.forename: Antonio
authors.initials: A
authors.lastname: Scaraggi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maccagnano
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vicenti
authors.forename: Biagio
authors.initials: B
authors.lastname: Moretti
mesh_terms: D019644:Arthroplasty, Replacement, Hip; D005167:Factor VII / Q000008:administration & dosage / Q000627:therapeutic use; D005269:Femur / Q000601:surgery; D050723:Fractures, Bone / Q000601:surgery; D006467:Hemophilia A; D006801:Humans; D019990:Perioperative Care
chemical_list: D005167:Factor VII