title: Synthesis and antidyslipidemic activity of chalcone fibrates.
abstract: A series of chalcone based PPAR-α agonists were synthesized and evaluated for their antidyslipidemic activity in high fructose high fat fed dyslipidemic Syrian golden hamsters. Most of the compounds exhibited antidyslipidemic activity. The compounds 4c and 4f have been identified as most potent antidyslipidemics. A definite structure-activity relationship was observed while varying the nature as well as the position of the substituent.
authors.affiliation: Medicinal and Process Chemistry, Central Drug Research Institute, MG Marg, Lucknow 226001, India.
authors.forename: Poonam
authors.initials: P
authors.lastname: Shukla
authors.forename: Swayam P
authors.initials: SP
authors.lastname: Srivastava
authors.forename: Rohit
authors.initials: R
authors.lastname: Srivastava
authors.forename: Arun K
authors.initials: AK
authors.lastname: Rawat
authors.forename: Arvind K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Ram
authors.initials: R
authors.lastname: Pratap
mesh_terms: D000818:Animals; D002599:Chalcone / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006224:Cricetinae; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D050171:Dyslipidemias / Q000188:drug therapy; D058607:Fibric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D058607:Fibric Acids; D000960:Hypolipidemic Agents; D002599:Chalcone