title: VIZ-GRAIL: visualizing functional connections across disease loci.
abstract: BACKGROUND
  As disease loci are rapidly discovered, an emerging challenge is to identify common pathways and biological functionality across loci. Such pathways might point to potential disease mechanisms. One strategy is to look for functionally related or interacting genes across genetic loci. Previously, we defined a statistical strategy, Gene Relationships Across Implicated Loci (GRAIL), to identify whether pair-wise gene relationships defined using PubMed text similarity are enriched across loci. Here, we have implemented VIZ-GRAIL, a software tool to display those relationships and to depict the underlying biological patterns.
  
  
  RESULTS
  Our tool can seamlessly interact with the GRAIL web site to obtain the results of analyses and create easy to read visual displays. To most clearly display results, VIZ-GRAIL arranges genes and genetic loci to minimize intersecting pair-wise gene connections. VIZ-GRAIL can be easily applied to other types of functional connections, beyond those from GRAIL. This method should help investigators appreciate the presence of potentially important common functions across loci.
  
  
  BACKGROUND
  The GRAIL algorithm is implemented online at http://www.broadinstitute.org/mpg/grail/grail.php. VIZ-GRAIL source-code is at http://www.broadinstitute.org/mpg/grail/vizgrail.html.
authors.affiliation: Divisions of Genetics and Rheumatology, Brigham and Women's Hospital, Boston, MA 02115, USA. soumya@broadinstitute.org
authors.forename: Soumya
authors.initials: S
authors.lastname: Raychaudhuri
mesh_terms: D000465:Algorithms; D003196:Computer Graphics; D004194:Disease / Q000235:genetics*; D005796:Genes; D056426:Genetic Loci; D012984:Software