title: A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila.
abstract: In this study, we show that the haplo-enhancer effect of JIL-1 has the ability to counterbalance the haplo-suppressor effect of both Su(var)3-9 and Su(var)2-5 on position-effect variegation, providing evidence that a finely tuned balance between the levels of JIL-1 and the major heterochromatin components contributes to the regulation of gene expression.
authors.affiliation: Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Jack
authors.initials: J
authors.lastname: Girton
authors.forename: Jørgen
authors.initials: J
authors.lastname: Johansen
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Johansen
mesh_terms: D000483:Alleles; D000818:Animals; D000090266:Chromobox Protein Homolog 5; D055012:Chromosomal Position Effects; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics; D022041:Euchromatin / Q000737:chemistry / Q000235:genetics; D006570:Heterochromatin / Q000737:chemistry / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D029721:Drosophila Proteins; D022041:Euchromatin; D006570:Heterochromatin; D012097:Repressor Proteins; C089148:Su(var)3-9 protein, Drosophila; D000090266:Chromobox Protein Homolog 5; C507306:JIL-1 protein, Drosophila; D017346:Protein Serine-Threonine Kinases