title: The relationship of PON1 QR 192 and LM 55 polymorphisms with serum paraoxonase activities of Turkish diabetic patients.
abstract: Paraoxonase (PON1) is a serum esterase responsible for the protection against xenobiotics toxicity such as paraoxon. Alterations in PON1 concentrations have been reported in a variety of diseases including diabetes mellitus (DM). It has been shown that the serum PON1 concentration and activity are decreased in patients with both type 1 and type 2 DM. This study aimed to investigate the lipid profiles and the relationship between PON1 activity and PON1, QR192 and LM55 polymorphisms in Turkish type 2 diabetic patients and non-diabetic control subjects. According to our results, RR variant had significantly higher PON activity than QQ and QR variants (p < 0.01) and LL variant had significantly higher PON activity than MM variant in both control and patient groups (p < 0.05). In conclusion, we found that PON1 192RR and 55LL genotypes are associated with higher PON activity than QQ and MM genotypes. This may be more protective to lipid peroxidation.
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan, Ankara, Turkey.
authors.forename: Durdu
authors.initials: D
authors.lastname: Altuner
authors.forename: Ilker
authors.initials: I
authors.lastname: Ates
authors.forename: Sinan H
authors.initials: SH
authors.lastname: Suzen
authors.forename: Gonul Varan
authors.initials: GV
authors.lastname: Koc
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Aral
authors.forename: Asuman
authors.initials: A
authors.lastname: Karakaya
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D008055:Lipids; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human