title: Perioperative hyperoxygenation and wound site infection following surgery for acute appendicitis: a randomized, prospective, controlled trial.
abstract: OBJECTIVE
  To assess the influence of hyperoxygenation on surgical site infection by using the most homogeneous study population.
  
  
  METHODS
  A randomized, prospective, controlled trial.
  
  
  METHODS
  Department of surgery in a government hospital.
  
  
  METHODS
  A total of 210 patients who underwent open surgery for acute appendicitis. In the study group, patients received 80% oxygen during anesthesia, followed by high-flow oxygen for 2 hours in the recovery room. The control group received 30% oxygen, as usual.
  
  
  METHODS
  Open appendectomy via incision in the right lower quadrant of the abdomen.
  
  
  METHODS
  Surgical site infection, mainly assessed by the ASEPSIS (additional treatment, serous discharge, erythema, purulent discharge, separation of deep tissues, isolation of bacteria, and stay in hospital prolonged >14 days) system score.
  
  
  RESULTS
  Surgical site infections were recorded in 6 of 107 patients (5.6%) in the study group vs 14 of 103 patients (13.6%) in the control group (P = .04). Significant differences in the ASEPSIS score were also found. The mean hospital stay was longer in the control group (2.92 days) compared with the study group (2.51 days) (P = .01).
  
  
  CONCLUSIONS
  The use of supplemental oxygen is advantageous in operations for acute appendicitis by reducing surgical site infection rate and hospital stay.
  
  
  BACKGROUND
  clinicaltrials.gov Identifier: NCT01002365.
authors.affiliation: Department of Surgery, Western Galilee Hospital, PO Box 21, Nahariya, Israel. amitai@netvision.net.il
authors.forename: Amitai
authors.initials: A
authors.lastname: Bickel
authors.forename: Michael
authors.initials: M
authors.lastname: Gurevits
authors.forename: Ronny
authors.initials: R
authors.lastname: Vamos
authors.forename: Simon
authors.initials: S
authors.lastname: Ivry
authors.forename: Arieh
authors.initials: A
authors.lastname: Eitan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001062:Appendectomy / Q000009:adverse effects; D001064:Appendicitis / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage*; D059035:Perioperative Period; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010100:Oxygen