title: Repair of bone cavities in dog's mandible filled with inorganic bovine bone and bioactive glass associated with platelet rich plasma.
abstract: The aim of this study was to evaluate the effect of platelet rich plasma (PRP) associated to bovine inorganic bone (Bio-Oss(®); Geistlich) or bioactive glass (Bio-Gran(®); Orthovita, Implant Innovations) on bone healing. Bone cavities were prepared in both sides of the mandible of 4 adult male dogs. The cavities were divided into 4 groups according to the filling material as follows: control, PRP, PRP/Bio-Oss, PRP/Bio-Gran. The animals were sacrificed after 120 days and histological and histomorphometrical analysis was performed. The control group showed 80.6% of bone formation in the longitudinal sections at 6 mm depth and 83.7% at 13 mm depth. The transverse sections displayed 74.2% at both 6 and 13 mm depths. The PRP group showed 21.1% of bone formation in the longitudinal sections at 6 mm depth, and 23.1% at 13 mm depth. The transverse sections presented 28.98% of bone formation at 6 mm depth and 41.2% at 13 mm depth. The PRP/Bio-Gran group showed 25.1% of bone formation in the longitudinal sections at 6 mm depth and 30.4% at 13 mm depth. In the transverse sections, the bone formation was 43.0% at 6 mm depth and 39.7% at 13 mm depth. The PRP/Bio-Oss group showed 35.5% of bone formation in the longitudinal sections at 6 mm depth and 42% at 13 mm depth. In the transversal sections, the bone formation was 26.8% and 31.2% at the depths of 6 and 13 mm, respectively. PRP alone or associated with bovine inorganic bone or bioglass had no significant effect in bone healing.
authors.affiliation: Department of Surgery and Integrated Clinic, Araçatuba Dental School, Univ. Estadual Paulista, SP, Brazil. apfbassi@ig.com.br
authors.forename: Ana Paula Farnezi
authors.initials: AP
authors.lastname: Bassi
authors.forename: Paulo Sérgio Perri de
authors.initials: PS
authors.lastname: Carvalho
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D002417:Cattle; D004285:Dogs; D005898:Glass; D008297:Male; D008334:Mandible; D008903:Minerals / Q000494:pharmacology; D053657:Platelet-Rich Plasma
chemical_list: C077540:Bio-Oss; D001672:Biocompatible Materials; C073544:Biogran; D018786:Bone Substitutes; D008903:Minerals