title: Tuberculosis infections and tumor necrosis factor alpha antagonists.
abstract: The treatment of rheumatologic diseases with tumor necrosis factor-alpha antagonists has become common practice. Studies have demonstrated an increased risk of active tuberculosis with use of tumor necrosis factor-alpha antagonists. We aim to better define the risk of tuberculosis infection associated with tumor necrosis factor-alpha antagonists and to review the literature on the treatment of latent tuberculosis.
authors.affiliation: Rush University Medical Center and John H. Stroger Jr Hospital of Cook County, Chicago, IL, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Gan
authors.forename: Augustine M
authors.initials: AM
authors.lastname: Manadan
authors.forename: Winston
authors.initials: W
authors.lastname: Sequiera
authors.forename: Joel A
authors.initials: JA
authors.lastname: Block
mesh_terms: D000068879:Adalimumab; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000627:therapeutic use; D000068800:Etanercept; D005060:Europe / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D000069285:Infliximab; D055985:Latent Tuberculosis / Q000188:drug therapy; D008403:Mass Screening; D011792:Quebec / Q000453:epidemiology; D018124:Receptors, Tumor Necrosis Factor; D014376:Tuberculosis / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D014481:United States / Q000453:epidemiology
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D000995:Antitubercular Agents; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D018124:Receptors, Tumor Necrosis Factor; D000069285:Infliximab; D000068879:Adalimumab; D000068800:Etanercept