title: New psoriasis susceptibility genes: momentum for skin-barrier disruption.
abstract: The epidermal differentiation complex gene cluster is on chromosome region 1q21.3, where the PSORS4 locus was mapped. A common deletion of two LCE genes (LCE3C_LCE3B-del) was associated with psoriasis. Individuals homozygous for the deletion have an impaired response of the skin barrier to exogenous agents, facilitating the systemic skin inflammation characteristic of psoriasis.
authors.affiliation: Genética Molecular, Hospital Universitario Central Asturias-Servicio de Salud del Principado de Asturias, Oviedo, Spain. eliecer.coto@sespa.princast.es
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.forename: Jorge
authors.initials: J
authors.lastname: Santos-Juanes
authors.forename: Pablo
authors.initials: P
authors.lastname: Coto-Segura
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
mesh_terms: D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D055233:Cornified Envelope Proline-Rich Proteins / Q000235:genetics; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006801:Humans; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D017384:Sequence Deletion
chemical_list: D055233:Cornified Envelope Proline-Rich Proteins