title: 18F-fluorodeoxyglucose uptake in tumor.
abstract: The 18fluorine-fluorodeoxyglucose (18F-FDG), a glucose analog, has been widely used in tumor imaging. The tumoral uptake of 18F-FDG is based upon enhanced glycolysis. Following administration, 18F-FDG is phosphorylated and trapped intracellularly that forms the basis of PET imaging. An important mechanism to transport 18F-FDG into the tumor cell is based upon the action of glucose transporter proteins; furthermore, highly active hexokinase bound to tumor mitochondria helps to trap 18F-FDG into the cell. In addition, enhanced 18F-FDG uptake may be due to relative hypoxia in tumor masses, which activates the anaerobic glycolytic pathway. In spite of these processes, 18F-FDG uptake is relatively nonspecific since all living cells need glucose. Clinical application of 18F-FDG imaging is therefore recommended in carefully selected patients.
authors.affiliation: Center for Nuclear Medicine & Ultrasound, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.
authors.forename: N
authors.initials: N
authors.lastname: Khan
authors.forename: M M
authors.initials: MM
authors.lastname: Islam
authors.forename: S
authors.initials: S
authors.lastname: Mahmood
authors.forename: G A
authors.initials: GA
authors.lastname: Hossain
authors.forename: R K
authors.initials: RK
authors.lastname: Chakraborty
mesh_terms: D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D050491:Glutamate Plasma Membrane Transport Proteins / Q000502:physiology; D006019:Glycolysis; D006593:Hexokinase / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D010766:Phosphorylation; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
chemical_list: D050491:Glutamate Plasma Membrane Transport Proteins; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D006593:Hexokinase