title: Squamous cell carcinoma in a thyroglossal duct cyst and 99mTc-MIBI findings.
abstract: The incidence of carcinomas in thyroglossal duct cysts is extremely low. The vast majority are papillary carcinomas, with only 14 cases of squamous cell carcinomas reported in the literature. A 78 years old male patient presented with an asymptomatic large mass in his anterior neck, considerably immobile, with inflamed overlying skin. Imaging studies confirmed the cystic nature-doughnut shape of the lesion, giving evidence of malignant infiltration of the surrounding tissues, without lymph node enlargement. Fine needle aspiration was positive for a possible squamous cell malignancy. A wide Sistrunk procedure was performed and the mass was excised along with the strap muscles and the infiltrated overlying skin. Histopathology confirmed the diagnosis of a moderately differentiated squamous cell carcinoma. In conclusion, scintigraphy with (99m)Tc-MIBI showed the characteristic doughnut sign. The rarity of this diagnosis along with differential diagnosis dilemmas are the key points of this presentation.
authors.affiliation: 3rd University Nuclear Medicine Department, Papageorgiou Hospital, Efkarpia ring road, 56403 Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Iakovou
authors.forename: Iordanis
authors.initials: I
authors.lastname: Konstantinidis
authors.forename: Argyrios
authors.initials: A
authors.lastname: Doumas
authors.forename: Vasilios
authors.initials: V
authors.lastname: Nikolaidis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Karatzas
authors.forename: Ioannis
authors.initials: I
authors.lastname: Efstratiou
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D017256:Technetium Tc 99m Sestamibi; D013955:Thyroglossal Cyst / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy
chemical_list: D017256:Technetium Tc 99m Sestamibi