title: An 18-year follow-up of a case of D-penicillamine-induced Elastosis perforans serpiginosa.
abstract: Elastosis perforans serpiginosa (EPS) is a rare complication of chronic therapy with a high-dose of D-penicillamine (1 g daily for more than 5 years), characterized by the elimination of abnormal elastic fibers from the upper dermis through the epidermis. D-penicillamine (DPA) is a heavy metal chelator primarily used for disorders such as cystinuria and Wilson disease. This therapy can lead to induction of EPS through a still unknown mechanism. We report the follow-up of a D-penicillamine-induced EPS in patient with Wilson disease, which prompted us to switch the therapy with trientine (another metal chelator). After 14 years the cutaneous lesions are still visible; therefore, we conclude that the DPA-induced cutaneous damage is irreversible.
authors.forename: M
authors.initials: M
authors.lastname: Carlesimo
authors.forename: A
authors.initials: A
authors.lastname: Narcisi
authors.forename: G
authors.initials: G
authors.lastname: Cortesi
authors.forename: E
authors.initials: E
authors.lastname: Mari
authors.forename: L
authors.initials: L
authors.lastname: Fidanza
authors.forename: G
authors.initials: G
authors.lastname: De Marco
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: G
authors.initials: G
authors.lastname: Camplone
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000009:adverse effects*; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology / Q000628:therapy
chemical_list: D010396:Penicillamine