title: Opioid peptides in peripheral pain control.
abstract: Opioids have a long history of therapeutic use as a remedy for various pain states ranging from mild acute nociceptive pain to unbearable chronic advanced or end-stage disease pain. Analgesia produced by classical opioids is mediated extensively by binding to opioid receptors located in the brain or the spinal cord. Nevertheless, opioid receptors are also expressed outside the CNS in the periphery and may become valuable assets in eliciting analgesia devoid of shortcomings typical for the activation of their central counterparts. The discovery of endogenous opioid peptides that participate in the formation, transmission, modulation and perception of pain signals offers numerous opportunities for the development of new analgesics. Novel peptidic opioid receptor analogs, which show limited access through the blood brain barrier may support pain therapy requiring prolonged use of opioid drugs.
authors.affiliation: Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland. alesniak.imdik@gmail.com.
authors.forename: Anna
authors.initials: A
authors.lastname: Lesniak
authors.forename: Andrzej W
authors.initials: AW
authors.lastname: Lipkowski
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D018847:Opioid Peptides / Q000378:metabolism / Q000627:therapeutic use*; D010525:Peripheral Nerves / Q000503:physiopathology*; D011957:Receptors, Opioid / Q000145:classification / Q000502:physiology
chemical_list: D000700:Analgesics; D018847:Opioid Peptides; D011957:Receptors, Opioid