title: The blue man: a novel cutaneous manifestation of systemic amyloidosis.
abstract: Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.
authors.affiliation: Division of Internal Medicine, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA. campbell.mark@mayo.edu
authors.forename: Mark
authors.initials: M
authors.lastname: Campbell
authors.forename: Allison
authors.initials: A
authors.lastname: Rosenthal
authors.forename: Madappa
authors.initials: M
authors.lastname: Kundranda
authors.forename: Amanda
authors.initials: A
authors.lastname: Pickert
authors.forename: David
authors.initials: D
authors.lastname: Dicaudo
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dogan
authors.forename: Joseph
authors.initials: J
authors.lastname: Mikhael
mesh_terms: D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D012871:Skin Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology*
chemical_list: D000682:Amyloid; D007145:Immunoglobulin kappa-Chains; C035222:amyloid protein AL