title: T-cell receptor specificity of CD8(+) Tregs in allotransplantation.
abstract: Recent studies in the field of CD8(+) Tregs have allowed a better identification and characterization of this subset of regulatory cells. Their key role in the regulation of allogeneic responses is now well established. To take full advantage of CD8(+) Treg cells in future therapeutic applications, a better knowledge is required, particularly concerning the contribution of the T-cell receptor (TCR) in cell function as well as the role and importance of its antigenic specificity. Here, we focused on the CD8(+)CD45RC(low) Tregs, which in rats induce an indefinite long-term allograft acceptance. We summarized recent findings on their interaction properties with antigen-presenting cells. Identification of the antigenic targets and TCR repertoire of CD8(+) Tregs will allow a better understanding of their recognition properties and will highlight the potential of such of specific population in cell-based treatment.
authors.affiliation: INSERM U643, Nantes, F44000, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Picarda
authors.forename: Ignacio
authors.initials: I
authors.lastname: Anegon
authors.forename: Carole
authors.initials: C
authors.lastname: Guillonneau
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016827:CD8 Antigens / Q000096:biosynthesis; D002450:Cell Communication; D006801:Humans; D016219:Immunotherapy, Adoptive; D023421:Models, Animal; D051381:Rats; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D037182:T-Cell Antigen Receptor Specificity; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D014181:Transplantation Immunology; D023001:Transplantation Tolerance; D014184:Transplantation, Homologous
chemical_list: D016827:CD8 Antigens; D011948:Receptors, Antigen, T-Cell