title: Syntheses, structures and antimicrobial activities of bis(imino)acenaphthene (BIAN) imidazolium salts.
abstract: The syntheses of four new bis(imino)acenaphthene (BIAN) imidazolium chlorides are reported, three of which have been structurally characterized. The synthesis of a new, structurally authenticated BIAN ligand is also described. We report the results of the use of these BIAN imidazolium salts as antimicrobials against the pathogens S. aureus, B. subtilis, E. coli and P. aeruginosa. The antimicrobial efficacies were particularly high for the N-(2,6-diisopropylphenyl)- and N-(mesityl)-substituted BIAN imidazolium salts (MIC values < 0.6 μg/mL).
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station, A5300, Austin, TX 78712, USA.
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Butorac
authors.forename: Salem S
authors.initials: SS
authors.lastname: Al-Deyab
authors.forename: Alan H
authors.initials: AH
authors.lastname: Cowley
mesh_terms: D000073:Acenaphthenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D018360:Crystallography, X-Ray; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000073:Acenaphthenes; D000900:Anti-Bacterial Agents; D007093:Imidazoles; C042552:acenaphthene