title: Synthesis and biological evaluation of new flavonoid fatty acid esters with anti-adipogenic and enhancing glucose consumption activities.
abstract: Oleoyl Formononetin (OF) has good weight loss activity and hypolipidemic activity, could improve insulin sensitivity and suppress adipogenesis. To acquire better biological activities, three series of flavonoid fatty acid esters were designed and synthesized by optimizing the structure of OF. Their bioactivities were assayed in vitro. Some of these novel compounds could effectively inhibit preadipocyte proliferation and adipogenesis. Moreover, they could enhance glucose consumption in adipocytes notably.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Tongjiaxiang, Nanjing, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.forename: Hua
authors.initials: H
authors.lastname: Xiang
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Zeng
authors.forename: Xiao-bo
authors.initials: XB
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
authors.forename: De-ying
authors.initials: DY
authors.lastname: Chen
authors.forename: Ren-ling
authors.initials: RL
authors.lastname: Ma
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects; D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D019440:Anti-Obesity Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005227:Fatty Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D051379:Mice; D008958:Models, Molecular; D009765:Obesity / Q000188:drug therapy
chemical_list: D019440:Anti-Obesity Agents; D004952:Esters; D005227:Fatty Acids; D005419:Flavonoids; D005947:Glucose