title: Orchestrating the synaptic network by tyrosine phosphorylation signalling.
abstract: The establishment of a functional brain requires coordinated and stereotyped formation of synapses between neurons. For this, trans-synaptic molecular cues (synaptic organizers) are exchanged between a neuron and its target to organize appropriate synapses. The understanding of signalling mechanisms by which such synaptic organizers lead to synapse formation is just being elucidated. However, recent studies revealed that some of these cues act through receptor protein tyrosine kinases (RPTKs) or phosphatases (RPTPs). Synaptogenic RPTKs and RPTPs pattern synaptic network through affecting local protein-protein binding dynamics, changing the phosphorylation state of signalling cascades, or promoting gene expression. Each RPTK or RPTP has distinct roles in synapse formation, serving at different synapses or showing differential synaptogenic effects. Thus, tyrosine phosphorylation signalling plays critical roles in building the orchestrated synaptic circuitry in the brain.
authors.affiliation: Molecular & Behavioral Neuroscience Institute, Medical Scientist Training Program, Neuroscience Graduate Program and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-2200, USA.
authors.forename: Ania
authors.initials: A
authors.lastname: Dabrowski
authors.forename: Hisashi
authors.initials: H
authors.lastname: Umemori
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D013569:Synapses / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*
chemical_list: D014443:Tyrosine; D020794:Receptor Protein-Tyrosine Kinases; D017027:Protein Tyrosine Phosphatases