title: Therapeutic application of histone deacetylase inhibitors for stroke.
abstract: Histone deacetylases (HDACs) play a key role in the homeostasis of histone acetylation and gene transcription. Histone hypoacetylation and transcriptional dysfunction have been identified in a large number of neurological diseases, including ischemic and hemorrhagic stroke. HDAC inhibitors (HDACi) have emerged as a promising therapeutic intervention in neurodegenerative disorders. Here we review and discuss recent observations in the application of the HDACi to combat the effects of stroke in animal and cell culture models. These agents raise histone acetylation levels, adjust the transcription of associated genes, and exert neuroprotective benefits against stroke. Clinical randomized trials should be performed to further investigate the benefits of HDACi for stroke patients.
authors.affiliation: Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, No.12 Mid. Wulumuqi Road, Shanghai 200040, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Lv
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
authors.forename: Xiang
authors.initials: X
authors.lastname: Han
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Dong
mesh_terms: D000818:Animals; D002543:Cerebral Hemorrhage / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D002986:Clinical Trials as Topic; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D015394:Molecular Structure; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D020521:Stroke / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
chemical_list: D056572:Histone Deacetylase Inhibitors; D006657:Histones; D007527:Isoenzymes; D006655:Histone Deacetylases