title: Special delivery: granulin brings CpG DNA to Toll-like receptor 9.
abstract: Foreign DNA activates the innate immune response through Toll-like receptor 9 (TLR9). In this issue of Immunity, Park et al. (2011) present evidence that granulin is a cofactor for TLR9 activation, delivering CpG-oligodeoxynucleotides to TLR9 in endolysosomes.
authors.affiliation: Department of Genetics, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Eva Marie Y
authors.initials: EM
authors.lastname: Moresco
authors.forename: Bruce
authors.initials: B
authors.lastname: Beutler