title: Association between the ratio of triglycerides to high-density lipoprotein cholesterol and chronic kidney disease in Korean adults: the 2005 Korean National Health and Nutrition Examination Survey.
abstract: BACKGROUND
  The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases. The purpose of this study was to examine the association between TG/HDL-C and chronic kidney disease (CKD) in a nationally representative sample of Korean adults.
  
  
  METHODS
  This cross-sectional study included 5,503 subjects (≥19 years of age) who participated in the 2005 Korean National Health and Nutrition Examination Survey. CKD was defined as an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m(2) as calculated by the abbreviated formula from the Modification of Diet in Renal Disease study.
  
  
  RESULTS
  The overall prevalence of CKD in our sample was 9.0%. eGFR was negatively correlated with logarithm-transformed TG/HDL-C in Pearson's correlation. The prevalence of CKD in increasing TG/HDL-C quintiles was 4.4, 6.6, 9.5, 11.9, and 12.8%. In comparison with the lowest quintile of TG/HDL-C (<1.38), the odds ratio (95% confidence interval) for CKD in the highest quintile of TG/HDL-C (≥4.50) was 2.15 (1.38-3.37), after adjustment for multiple covariates (p value for trend = 0.036).
  
  
  CONCLUSIONS
  TG/HDL-C was independently associated with increased prevalence of CKD in a sample of Korean adults.
authors.affiliation: Department of Family Medicine, Wonju College of Medicine, Yonsei University, Wonju, South Korea.
authors.forename: Hee-Taik
authors.initials: HT
authors.lastname: Kang
authors.forename: Jae-Yong
authors.initials: JY
authors.lastname: Shim
authors.forename: Yong-Jae
authors.initials: YJ
authors.lastname: Lee
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: John A
authors.initials: JA
authors.lastname: Linton
authors.forename: Jong-Koo
authors.initials: JK
authors.lastname: Kim
authors.forename: Hye-Ree
authors.initials: HR
authors.lastname: Lee
mesh_terms: D000328:Adult; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology; D008076:Cholesterol, HDL / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D005919:Glomerular Filtration Rate; D006306:Health Surveys; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D007677:Kidney Function Tests; D007723:Korea / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D012372:ROC Curve; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D014280:Triglycerides