title: [Study on differences between pharmacokinetics and chromatopharmacodynamics for Chinese materia medica formulae].
abstract: OBJECTIVE
  To study on the differences between chromatopharmacokinetics (pharmacokinetics with fingerprint chromatography) and chromatopharmacodynamics (pharmacodynamics with fingerprint chromatography) of Chinese materia medica formulae to answer the question whether the pharmacokinetic parameters of multiple composites can be utilized to guide the medication of multiple composites.
  
  
  METHODS
  On the base of established four chromatopharmacology (pharmacology with chromatographic fingerprint), the pharmacokinetics, and pharmacodynamics were analyzed comparably on their mathematical model and parameter definition.
  
  
  RESULTS
  On the basis of quantitative pharmacology, the function expressions and total statistical parameters, such as total zero moment, total first moment, total second moment of the pharmacokinetics, and pharmacodynamics were analyzed to the common expressions and elucidated results for single and multiple components in Chinese materia medica formulae. Total quantitative pharmacokinetic, i.e., chromatopharmacokinetic parameter were decided by each component pharmacokinetic parameters, whereas the total quantitative pharmacodynamic, i.e., chromatopharmacodynamic parameter were decided by both of pharmacokinetic and pharmacodynamic parameters of each components. The pharmacokinetic parameters were corresponded to pharmacodynamic parameters with an existing stable effective coefficient when the constitutive ratio of each composite was a constant.
  
  
  CONCLUSIONS
  The effects of Chinese materia medica were all controlled by pharmacokinetic and pharmacodynamic coefficient. It is a special case that the pharmacokinetic parameter could independently guide the clinical medication for single component whereas the chromatopharmacokinetic parameters are not applied to the multiple drug combination system, and not be used to solve problems of chromatopharmacokinetic of Chinese materia medica formulae.
authors.affiliation: Property and pharmacodaynamic Key laboratory of TCMM, State Administration of Traditional Chinese Medicine, Department of Pharmaceutics, Hunan University of Tradition Chinese Medicine, Changsha 410208, China. pharmsharking@tom.com
authors.forename: Fuyuan
authors.initials: F
authors.lastname: He
authors.forename: Kaiwen
authors.initials: K
authors.lastname: Deng
authors.forename: Huan
authors.initials: H
authors.lastname: Zou
authors.forename: Yun
authors.initials: Y
authors.lastname: Qiu
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Honghao
authors.initials: H
authors.lastname: Zhou
mesh_terms: D002845:Chromatography; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics*; D008419:Materia Medica / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D008419:Materia Medica