title: Histomorphometric analysis following augmentation of the posterior mandible using cancellous bone-block allograft.
abstract: The present study was conducted to histologically and histomorphometrically evaluate the application of cancellous bone-block allografts for the augmentation of the posterior atrophic mandible. Twenty-four consecutive patients underwent augmentation with cancellous bone-block allografts in the posterior mandible. A bony deficiency of at least 3 mm horizontally and/or vertically according to CT para-axial reconstruction served as inclusion criteria. Following 6 months, 85 implants were placed and a cylindrical sample core was collected. All specimens were prepared for histological and histomorphometrical examination. Implant survival rate was 95.3%. Follow-up ranged 12-66 months (mean 43 ± 19 months). The mean newly formed bone was 44 ± 28%, that of the residual cancellous bone-block allograft 29 ± 24%, and of the marrow and connective tissue 27 ± 21%. Statistically significant histomorphometric differences regarding newly formed bone (69% vs. 31%, p = 0.05) were found between younger (< 45 years) and older (> 45 years) patients, respectively. Histomorphometric differences regarding residual cancellous bone-block allograft (17% vs. 35%) and of the marrow and connective tissue (14% vs. 34%) were not statistically significant. Cancellous bone-block allograft is biocompatible and osteoconductive, permitting new bone formation following augmentation of extremely atrophic posterior mandible with a two-stage implant placement procedure. New bone formation was age-dependent.
authors.affiliation: Department of Oral Rehabilitation, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, 4 Klachkin Street, Tel Aviv, Israel. nissandr@post.tau.ac.il
authors.forename: Joseph
authors.initials: J
authors.lastname: Nissan
authors.forename: Vered
authors.initials: V
authors.lastname: Marilena
authors.forename: Ora
authors.initials: O
authors.lastname: Gross
authors.forename: Ofer
authors.initials: O
authors.lastname: Mardinger
authors.forename: Gavriel
authors.initials: G
authors.lastname: Chaushu
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D016025:Bone Transplantation; D015921:Dental Implants; D003793:Dental Restoration, Permanent; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D008875:Middle Aged; D019647:Oral Surgical Procedures / Q000379:methods*; D011859:Radiography; D014184:Transplantation, Homologous
chemical_list: D015921:Dental Implants