title: Active platelet 5-ht uptake in depressives treated with impramine and ect.
abstract: Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed.
authors.affiliation: P.K. DALAL, M.D., Associate Professor, Department Psychiatry, K.G.'s Medical College, Lucknow.
authors.forename: P K
authors.initials: PK
authors.lastname: Dalal
authors.forename: N
authors.initials: N
authors.lastname: Lal
authors.forename: J K
authors.initials: JK
authors.lastname: Trivedi
authors.forename: P K
authors.initials: PK
authors.lastname: Seth
authors.forename: A K
authors.initials: AK
authors.lastname: Agarwal
authors.forename: A
authors.initials: A
authors.lastname: Khalid