title: Transient splenial lesion of the corpus callosum in H1N1 influenza virus-associated encephalitis/encephalopathy.
abstract: A 26-year-old man was admitted to our hospital because of high fever, drowsiness, memory disturbance, and disorientation due to H1N1 influenza virus-associated encephalitis/encephalopathy. All of his symptoms rapidly improved following methylprednisolone pulse therapy. The diffusion-weighted image of brain magnetic resonance imaging (MRI) revealed a large transient hyperintense signal lesion on the central splenium of the corpus callosum. This MRI finding in conjunction with a complete clinical recovery has been previously observed in cases of clinically mild seasonal influenza-associated encephalitis/encephalopathy, and can be also a useful clue for the diagnosis of new type of influenza, H1N1 influenza virus infection complicated by encephalitis/encephalopathy.
authors.affiliation: Department of Neurology, Fujita Health University School of Medicine, Japan. shindi@fujita-hu.ac.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Ito
authors.forename: Sayuri
authors.initials: S
authors.lastname: Shima
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ueda
authors.forename: Naoki
authors.initials: N
authors.lastname: Kawamura
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Asakura
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Mutoh
mesh_terms: D000328:Adult; D003337:Corpus Callosum / Q000473:pathology*; D003402:Creatine Kinase / Q000097:blood; D038524:Diffusion Magnetic Resonance Imaging; D018792:Encephalitis, Viral / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications / Q000473:pathology*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000201:enzymology / Q000209:etiology
chemical_list: D003402:Creatine Kinase; D008775:Methylprednisolone