title: Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice.
authors.forename: E
authors.initials: E
authors.lastname: Beurel
authors.forename: L
authors.initials: L
authors.lastname: Song
authors.forename: R S
authors.initials: RS
authors.lastname: Jope
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology*; D003863:Depression / Q000188:drug therapy; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D055879:Gene Knock-In Techniques; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D000071679:Glycogen Synthase Kinase 3 beta; D006380:Helplessness, Learned; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology*; D007649:Ketamine / Q000494:pharmacology*; D018021:Lithium Chloride / Q000494:pharmacology; D051379:Mice; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D010766:Phosphorylation / Q000187:drug effects; D010768:Phosphoserine / Q000378:metabolism*; D017354:Point Mutation; D011499:Protein Processing, Post-Translational / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D009419:Nerve Tissue Proteins; D010768:Phosphoserine; D007649:Ketamine; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3; C448021:glycogen synthase kinase 3 alpha; D018021:Lithium Chloride