title: Facile and unified approach to skeletally diverse, privileged scaffolds.
abstract: A novel strategy has been developed to generate a diverse array of privileged scaffolds from readily available tetrahydropyridine precursors that may be prepared by a multicomponent assembly process followed by a ring-closing metathesis. The functionality embedded in these key intermediates enables their facile elaboration into more complex structures of biological relevance by a variety of ring-forming processes and refunctionalizations.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
authors.forename: James J
authors.initials: JJ
authors.lastname: Sahn
authors.forename: Justin Y
authors.initials: JY
authors.lastname: Su
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D011725:Pyridines