title: Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: a new indication for propranolol treatment.
abstract: Kaposiform hemangioendothelioma is a rare vascular tumor in children. Especially, in association with the Kasabach-Merritt Phenomenon it can be life threatening. The management of these patients is very difficult and an aggressive treatment regime is required. Several multimodality and chemotherapeutic regimens have been described but with variable success and many side effects. We present a 6-week-old boy with Kaposiform hemangioendothelioma and Kasabach-Merritt Phenomenon. Ongoing propranolol treatment with only 4 initial courses of vincristine resulted in a remission that lasted at least 1 year.
authors.affiliation: Department of Dermatology, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Denise Josephina Johanna
authors.initials: DJ
authors.lastname: Hermans
authors.forename: Ingrid Mathilde
authors.initials: IM
authors.lastname: van Beynum
authors.forename: Rozemarijn Junelle
authors.initials: RJ
authors.lastname: van der Vijver
authors.forename: Leonardus Jan Schultze
authors.initials: LJ
authors.lastname: Kool
authors.forename: Ivo
authors.initials: I
authors.lastname: de Blaauw
authors.forename: Catharina Joanna Maria
authors.initials: CJ
authors.lastname: van der Vleuten
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000209:etiology; D004359:Drug Therapy, Combination; D006390:Hemangioendothelioma / Q000150:complications / Q000188:drug therapy; D018324:Hemangioma, Capillary / Q000188:drug therapy / Q000209:etiology; D006392:Hemangioma, Cavernous / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007223:Infant; D059885:Kasabach-Merritt Syndrome; D008297:Male; D011433:Propranolol / Q000008:administration & dosage*; D012074:Remission Induction; D012514:Sarcoma, Kaposi / Q000150:complications / Q000188:drug therapy; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy; D013921:Thrombocytopenia / Q000150:complications / Q000188:drug therapy; D019043:Vascular Neoplasms / Q000150:complications / Q000188:drug therapy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000319:Adrenergic beta-Antagonists; D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine; D011433:Propranolol