title: Structural biology of Mycobacterium tuberculosis proteins: the Indian efforts.
abstract: Among the many different objectives of large scale structural genomics projects are expanding the protein fold space, enhancing understanding of a model or disease-related organism, and providing foundations for structure-based drug discovery. Systematic analysis of protein structures of Mycobacterium tuberculosis has been ongoing towards meeting some of these objectives. Indian participation in these efforts has been enthusiastic and substantial. The proteins of M. tuberculosis chosen for structural analysis by the Indian groups span almost all the functional categories. The structures determined by the Indian groups have led to significant improvement in the biochemical knowledge on these proteins and consequently have started providing useful insights into the biology of M. tuberculosis. Moreover, these structures form starting points for inhibitor design studies, early results of which are encouraging. The progress made by Indian structural biologists in determining structures of M. tuberculosis proteins is highlighted in this review.
authors.affiliation: Molecular and Structural Biology Division, Central Drug Research Institute, CSIR, Chattar Manzil Palace, MG Road, Lucknow 226001, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Arora
authors.forename: Nagasuma R
authors.initials: NR
authors.lastname: Chandra
authors.forename: Amit
authors.initials: A
authors.lastname: Das
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Gopal
authors.forename: Shekhar C
authors.initials: SC
authors.lastname: Mande
authors.forename: Balaji
authors.initials: B
authors.lastname: Prakash
authors.forename: Ravishankar
authors.initials: R
authors.lastname: Ramachandran
authors.forename: Rajan
authors.initials: R
authors.lastname: Sankaranarayanan
authors.forename: K
authors.initials: K
authors.lastname: Sekar
authors.forename: Kaza
authors.initials: K
authors.lastname: Suguna
authors.forename: Anil K
authors.initials: AK
authors.lastname: Tyagi
authors.forename: Mamannamana
authors.initials: M
authors.lastname: Vijayan
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D019295:Computational Biology; D018360:Crystallography, X-Ray; D016680:Genome, Bacterial; D006801:Humans; D007194:India; D008967:Molecular Biology; D009169:Mycobacterium tuberculosis / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins