title: Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates circulating in China by multilocus PCR and electrospray ionization mass spectrometry.
abstract: We used multilocus PCR and electrospray ionization mass spectrometry (PCR/ESI-MS) to determine the genotype and drug resistance profiles for 96 Mycobacterium tuberculosis isolates circulating in regions of high and low tuberculosis (TB) endemicity in China. The dominant principal genetic group (PGG) circulating in China was PGG1, and drug-resistant gene mutations were more diversified in the region of low rather than high TB endemicity.
authors.affiliation: Department of Infectious Diseases, Huashan Hospital,and Institute of Biomedical Sciences, Fudan University, Shanghai, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Wang
authors.forename: Christian
authors.initials: C
authors.lastname: Massire
authors.forename: Haijing
authors.initials: H
authors.lastname: Li
authors.forename: Lendell L
authors.initials: LL
authors.lastname: Cummins
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Jialin
authors.initials: J
authors.lastname: Jin
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Fan
authors.forename: Sen
authors.initials: S
authors.lastname: Wang
authors.forename: Lingyun
authors.initials: L
authors.lastname: Shao
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.forename: Shufang
authors.initials: S
authors.lastname: Meng
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Chanyi
authors.initials: C
authors.lastname: Lu
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Blyn
authors.forename: Rangarajan
authors.initials: R
authors.lastname: Sampath
authors.forename: David J
authors.initials: DJ
authors.lastname: Ecker
authors.forename: Wenhong
authors.initials: W
authors.lastname: Zhang
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Tang
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D002681:China / Q000453:epidemiology; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D019353:Endemic Diseases; D005838:Genotype; D006801:Humans; D058889:Molecular Typing / Q000379:methods*; D020125:Mutation, Missense; D009169:Mycobacterium tuberculosis / Q000737:chemistry* / Q000235:genetics* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction / Q000379:methods*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial