title: Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues.
abstract: Two new peloruside congeners (3 and 4) were isolated from wild and aquacultured collections of the New Zealand marine sponge Mycale hentscheli. Small-scale reactions on peloruside A (1) have been performed, which along with the isolation of 3 and 4, give further insight into the bioactive pharmacophore of 1.
authors.affiliation: Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand.
authors.forename: A Jonathan
authors.initials: AJ
authors.lastname: Singh
authors.forename: Mina
authors.initials: M
authors.lastname: Razzak
authors.forename: Paul
authors.initials: P
authors.lastname: Teesdale-Spittle
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Gaitanos
authors.forename: Anja
authors.initials: A
authors.lastname: Wilmes
authors.forename: Ian
authors.initials: I
authors.lastname: Paterson
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Goodman
authors.forename: John H
authors.initials: JH
authors.lastname: Miller
authors.forename: Peter T
authors.initials: PT
authors.lastname: Northcote
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D017756:Aquaculture; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D005434:Flow Cytometry; D018922:HL-60 Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008870:Microtubules / Q000187:drug effects; D009520:New Zealand; D011161:Porifera / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones; C414085:peloruside A