title: Xylarenones C-E from an endophytic fungus isolated from Alibertia macrophylla.
abstract: Xylarenones C-E (2-4), three new eremophilane sesquiterpenes, have been isolated from solid substrate cultures of a Camarops-like endophytic fungus isolated from Alibertia macrophylla. The structures were elucidated by analysis of spectroscopic data. Compounds were evaluated in subtilisin and pepsin protease assays, and compound 2 showed potent inhibitory activity against both proteases.
authors.affiliation: NuBBE, Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista, Rua Professor Francisco Degni s/n, Araraquara, São Paulo, Brazil.
authors.forename: Camila Martins
authors.initials: CM
authors.lastname: de Oliveira
authors.forename: Geraldo Humberto
authors.initials: GH
authors.lastname: Silva
authors.forename: Luis Octávio
authors.initials: LO
authors.lastname: Regasini
authors.forename: Otávio
authors.initials: O
authors.lastname: Flausino
authors.forename: Silvia Noelí
authors.initials: SN
authors.lastname: López
authors.forename: Bárbara Marcondes
authors.initials: BM
authors.lastname: Abissi
authors.forename: Roberto Gomes de Souza
authors.initials: RG
authors.lastname: Berlinck
authors.forename: Lara Durães
authors.initials: LD
authors.lastname: Sette
authors.forename: Rafaella Costa
authors.initials: RC
authors.lastname: Bonugli-Santos
authors.forename: André
authors.initials: A
authors.lastname: Rodrigues
authors.forename: Vanderlan da Silva
authors.initials: Vda S
authors.lastname: Bolzani
authors.forename: Angela Regina
authors.initials: AR
authors.lastname: Araujo
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000737:chemistry* / Q000235:genetics; D001483:Base Sequence; D001938:Brazil; D004271:DNA, Fungal / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010434:Pepsin A / Q000037:antagonists & inhibitors*; D019666:Rubiaceae / Q000382:microbiology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013381:Subtilisins / Q000037:antagonists & inhibitors*; D013552:Swine
chemical_list: D004271:DNA, Fungal; D012717:Sesquiterpenes; C561332:xylarenone C; C561333:xylarenone D; C561334:xylarenone E; D013381:Subtilisins; D010434:Pepsin A