title: The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability.
abstract: The taccalonolides are novel antimitotic microtubule stabilizers that have a unique mechanism of action independent of a direct interaction with tubulin. Cytotoxicity and clonogenic assays show that taccalonolide A and radiation act in an additive manner to cause cell death. The taxanes and epothilones have utility when combined with radiotherapy and these findings further suggest the additive effects of microtubule targeting agents with radiation on cellular proliferation are independent of direct tubulin binding and are instead a result of the downstream effects of these agents. These studies suggest that diverse antimitotic agents, including the taccalonolides, may have utility in chemoradiotherapy.
authors.affiliation: Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States. Electronic address: risingera@uthscsa.edu.
authors.forename: April L
authors.initials: AL
authors.lastname: Risinger
authors.affiliation: Department of Otolaryngology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
authors.forename: Mohan
authors.initials: M
authors.lastname: Natarajan
authors.affiliation: Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
authors.forename: Charles R
authors.initials: CR
authors.lastname: Thomas
authors.affiliation: Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States. Electronic address: Mooberry@uthscsa.edu.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Mooberry
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D049109:Cell Proliferation / Q000187:drug effects* / Q000528:radiation effects*; D003131:Combined Modality Therapy; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008870:Microtubules / Q000187:drug effects / Q000528:radiation effects; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D013256:Steroids / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014410:Tumor Stem Cell Assay
chemical_list: D013256:Steroids; C475870:taccalonolide A; C475869:taccalonolide E