title: Drosophila TIEG is a modulator of different signalling pathways involved in wing patterning and cell proliferation.
abstract: Acquisition of a final shape and size during organ development requires a regulated program of growth and patterning controlled by a complex genetic network of signalling molecules that must be coordinated to provide positional information to each cell within the corresponding organ or tissue. The mechanism by which all these signals are coordinated to yield a final response is not well understood. Here, I have characterized the Drosophila ortholog of the human TGF-β Inducible Early Gene 1 (dTIEG). TIEG are zinc-finger proteins that belong to the Krüppel-like factor (KLF) family and were initially identified in human osteoblasts and pancreatic tumor cells for the ability to enhance TGF-β response. Using the developing wing of Drosophila as "in vivo" model, the dTIEG function has been studied in the control of cell proliferation and patterning. These results show that dTIEG can modulate Dpp signalling. Furthermore, dTIEG also regulates the activity of JAK/STAT pathway suggesting a conserved role of TIEG proteins as positive regulators of TGF-β signalling and as mediators of the crosstalk between signalling pathways acting in a same cellular context.
authors.affiliation: Centro de Biología Molecular Severo Ochoa CSIC-UAM, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain. irodriguez@cbm.uam.es
authors.forename: Isabel
authors.initials: I
authors.lastname: Rodriguez
mesh_terms: D000375:Aging; D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D019521:Body Patterning / Q000235:genetics; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000737:chemistry* / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect / Q000235:genetics; D005816:Genetic Complementation Test; D006801:Humans; D053612:Janus Kinases / Q000378:metabolism; D008969:Molecular Sequence Data; D010641:Phenotype; D012097:Repressor Proteins / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation / Q000235:genetics; D014921:Wings, Animal / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism
chemical_list: C506602:Cbt protein, Drosophila; D029721:Drosophila Proteins; D012097:Repressor Proteins; D050791:STAT Transcription Factors; D014157:Transcription Factors; D053612:Janus Kinases