title: Taccasubosides A-D, four new steroidal glycosides from Tacca subflabellata.
abstract: By analyzing the steroidal content of fresh whole plants of Tacca subflabellata (Taccaceae), we isolated one sapogenin and eight glycosides with four kinds of steroidal skeletons including four new glycosides, named taccasubosides A-D (1-4), together with five known compounds. Among them, compound 1 is the first pentacyclic sterol glycoside with 6-6-6-5-6 fused rings. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analysis, including that of 2D NMR data, and the results of acidic hydrolysis. The cytotoxicity of the selected steroidal glycosides (1-4, 8, and 9) was evaluated in vitro against five human cancer cell lines. Compound 9 showed significant inhibitory activity against all five cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Ni
authors.forename: Xing-Rao
authors.initials: XR
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Hua
authors.forename: Ping-Lei
authors.initials: PL
authors.lastname: Fang
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Kong
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Pan
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Chang-Xiang
authors.initials: CX
authors.lastname: Chen
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
mesh_terms: D045744:Cell Line, Tumor; D027743:Dioscoreaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D006027:Glycosides