title: iRhoms: ERADicating the messenger in growth control signaling.
abstract: iRhoms are inactive rhomboid-like pseudoproteases that lack essential catalytic residues. Although iRhoms are highly conserved in metazoan species, little is known about their function. In a recent issue of Cell, Zettl et al. (2011) show that iRhoms regulate growth factor signaling through endoplasmic reticulum-associated protein degradation (ERAD).
authors.affiliation: Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
authors.forename: Stewart Siyan
authors.initials: SS
authors.lastname: Cao
authors.forename: Randal J
authors.initials: RJ
authors.lastname: Kaufman