title: Liver transplantation as a treatment for complicated bile duct injury.
abstract: OBJECTIVE
  Bile duct injury during cholecystectomy can be successfully managed by biliary reconstruction in the majority of patients. However it can also lead to potentially severe complications with unpredictable long-term results and in fact a proportion of these cases may even require liver transplantation.
  
  
  METHODS
  In recent years, two cases of complicated bile duct injury after the failure of traditional surgical interventions were admitted to our hospital. Both patients underwent liver transplantation successfully, and the detailed clinical data was analyzed retrospectively.
  
  
  RESULTS
  Bile duct injury (Strasberg type E4) in one patient was caused by laparoscopic cholecystectomy associated with proper hepatic artery injury; after the failure of an initial Roux-en-Y hepaticojejunostomy, the patient underwent classical orthotopic liver transplantation. Bile duct injury (Strasberg type D) in the other patient was caused by abdominal trauma in his childhood. After several unsuccessful surgical interventions, the patient finally developed secondary biliary cirrhosis twelve years later. He therefore underwent a living related liver transplantation. The outcome of both patients was satisfactory.
  
  
  CONCLUSIONS
  Liver transplantation should be considered when bile duct injury has occurs concomitant with severe vascular injury or secondary biliary cirrhosis appears after failure of surgical intervention.
authors.affiliation: Department of Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.
authors.forename: Ji-Qi
authors.initials: JQ
authors.lastname: Yan
authors.forename: Cheng-Hong
authors.initials: CH
authors.lastname: Peng
authors.forename: Bai-Yong
authors.initials: BY
authors.lastname: Shen
authors.forename: Guang-Wen
authors.initials: GW
authors.lastname: Zhou
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Yang
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Chen
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Li
mesh_terms: D000007:Abdominal Injuries / Q000150:complications; D000063:Accidents, Traffic; D000328:Adult; D000713:Anastomosis, Roux-en-Y / Q000009:adverse effects; D001652:Bile Ducts / Q000293:injuries*; D002675:Child, Preschool; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D006499:Hepatic Artery / Q000293:injuries; D006801:Humans; D007049:Iatrogenic Disease; D008103:Liver Cirrhosis / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies