title: A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation.
abstract: Renal amyloidosis is typically characterized by nephrotic syndrome, often with massive proteinuria and refractory peripheral edema. We report the case of a patient with renal amyloidosis associated with nephrotic syndrome who maintained remission for 6 years after undergoing high-dose chemotherapy followed by autologous peripheral blood stem-cell transplantation (auto-PBSCT). The patient was a man aged in his 50s who had developed nephrotic syndrome. Bone marrow aspiration and kidney biopsy determined that the cause of the nephrotic syndrome was renal amyloidosis due to multiple myeloma, and the patient was admitted to our department in July 2003. After one course of chemotherapy, auto-PBSCT was performed in March 2004. Following transplantation, serum M-protein was no longer detectable from March 2005, and the patient achieved complete hematological remission. Subsequently, proteinuria decreased, serum albumin levels normalized, and nephrotic syndrome improved. As of 6 years after transplantation, in March 2010, the patient remained in remission, meaning that auto-PBSCT proved extremely effective as a treatment for renal amyloidosis in this case.
authors.affiliation: Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan. kogawa@fmu.ac.jp
authors.forename: Kazuei
authors.initials: K
authors.lastname: Ogawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ikeda
authors.forename: Miki
authors.initials: M
authors.lastname: Furukawa
authors.forename: Kayo
authors.initials: K
authors.lastname: Harada-Shirado
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Mashimo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Hayato
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kimura
authors.forename: Akiko
authors.initials: A
authors.lastname: Shichishima-Nakamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohkawara
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Asahi
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Noji
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohto
authors.forename: Yasuchika
authors.initials: Y
authors.lastname: Takeishi
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000628:therapy*; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D012074:Remission Induction
chemical_list: D006023:Glycoproteins; C023587:protein M (glycoprotein)