title: Incremental third-party costs associated with COPD exacerbations: a retrospective claims analysis.
abstract: BACKGROUND
  Exacerbations are a major contributor to the large burden of treating chronic obstructive pulmonary disease (COPD). Estimates of exacerbation costs in the United States are limited.
  
  
  OBJECTIVE
  To estimate incremental costs associated with COPD exacerbation, particularly severe exacerbation, in the United States.
  
  
  METHODS
  COPD patients with at least one exacerbation were identified in the Thomson Reuters MarketScan administrative claims database. A COPD exacerbation was defined as patient use of oral or parenteral corticosteroids on the same day or within 7 days following a claim with a COPD diagnosis. Severe exacerbation was further defined if the exacerbation was associated with hospitalization or death. Healthcare costs and exacerbations were evaluated at quarterly intervals starting from patients' first observed claim with COPD diagnostic code in the database. Incremental costs associated with exacerbation were estimated as cost differences between quarters with exacerbation and quarters without exacerbation.
  
  
  RESULTS
  A total of 2644,174 patient-quarters, derived from 228,978 COPD patients, were included in the analysis. The average patient was followed an average of 2.9 years. The mean total cost was $17,016 per patient-quarter with severe exacerbation, $6628 per patient-quarter with non-severe exacerbation, an average of $8726 per patient-quarters with any exacerbation compared to $4762 per patient-quarter with no exacerbation. After adjusting for patient demographics, the mean incremental total cost was $11,261 per patient-quarter with severe exacerbation, $1509 per patient-quarter for non-severe exacerbation, and $3439 per patient-quarter with any exacerbation compared with patient-quarters with no exacerbation.
  
  
  CONCLUSIONS
  The method used for defining exacerbations does not capture mild exacerbations. Additional limitations exist due to the nature of claims data.
  
  
  CONCLUSIONS
  Exacerbations, especially severe ones, result in a significant economic burden for third-party payers. Effective management of COPD and prevention of exacerbations may lead to improved patient outcomes and reduction in total healthcare costs for long-term management of COPD.
authors.affiliation: Analysis Group Inc., Boston, MA, USA.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Yu
authors.forename: Hongbo
authors.initials: H
authors.lastname: Yang
authors.forename: Eric Q
authors.initials: EQ
authors.lastname: Wu
authors.forename: Juliana
authors.initials: J
authors.lastname: Setyawan
authors.forename: Michelle
authors.initials: M
authors.lastname: Mocarski
authors.forename: Steven
authors.initials: S
authors.lastname: Blum
mesh_terms: D000368:Aged; D005260:Female; D017048:Health Care Costs; D006801:Humans; D007345:Insurance Claim Review; D007348:Insurance, Health / Q000191:economics*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000191:economics* / Q000503:physiopathology*; D014481:United States