title: Cerebellar nuclei are activated by high-frequency stimulation of the subthalamic nucleus.
abstract: The cerebellum, primarily considered a pure motor structure, is increasingly considered to play a role in behaviour and cognition. In a similar manner, there is increasing evidence that the basal ganglia are involved in non-motor processes. Recently a direct connection between the cerebellum and the basal ganglia has been shown to exist. High-frequency stimulation (HFS) of the subthalamic nucleus (STN) has become an accepted treatment in advanced Parkinson's disease (PD). We performed HFS of the STN in rats to evaluate the neuronal activation in the deep cerebellar nuclei (DCbN) using c-Fos immunohistochemistry. We found an increased c-Fos expression in the DCbN. Previously, we have shown that STN HFS in rats leads to decreased impulsive behaviour and our findings now suggest a link with increased DCbN activity. This is in line with our previous work showing that decreased DCbN activity is accompanied by disruptive behaviour. We suggest that the DCbN play a role in the selection of relevant information on which a behavioural response is based. The connection between the cerebellum and the basal ganglia may imply a role for the cerebellum in behavioural aspects of disorders of the basal ganglia.
authors.affiliation: Department of Neuroscience, Maastricht University, Maastricht, The Netherlands. v.moers@mumc.nl
authors.forename: Véronique M P
authors.initials: VM
authors.lastname: Moers-Hornikx
authors.forename: Johan S H
authors.initials: JS
authors.lastname: Vles
authors.forename: Sonny K H
authors.initials: SK
authors.lastname: Tan
authors.forename: Kimberly
authors.initials: K
authors.lastname: Cox
authors.forename: Govert
authors.initials: G
authors.lastname: Hoogland
authors.forename: W M Harry
authors.initials: WM
authors.lastname: Steinbusch
authors.forename: Yasin
authors.initials: Y
authors.lastname: Temel
mesh_terms: D000818:Animals; D002529:Cerebellar Nuclei / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D013788:Thalamus / Q000502:physiology*
chemical_list: D016760:Proto-Oncogene Proteins c-fos