title: Computational fluid dynamics-based hydraulic and hemolytic analyses of a novel left ventricular assist blood pump.
abstract: The advent of various technologies has allowed mechanical blood pumps to become more reliable and versatile in recent decades. In our study group, a novel structure of axial flow blood pump was developed for assisting the left ventricle. The design point of the left ventricular assist blood pump 25 (LAP-25) was chosen at 4 Lpm with 100 mm Hg according to our clinical practice. Computational fluid dynamics was used to design and analyze the performance of the LAP-25. In order to obtain a required hydraulic performance and a satisfactory hemolytic property in the LAP-25 of a smaller size, a novel structure was developed including an integrated shroud impeller, a streamlined impeller hub, and main impeller blades with splitter blades; furthermore, tandem cascades were introduced in designing the diffuser. The results of numerical simulation show the LAP-25 can generate flow rates of 3-5 Lpm at rotational speeds of 8500-10,500 rpm, producing pressure rises of 27.5-148.3 mm Hg with hydraulic efficiency points ranging from 13.4 to 27.5%. Moreover, the fluid field and the hemolytic property of the LAP-25 were estimated, and the mean hemolysis index of the pump was 0.0895% with Heuser's estimated model. In conclusion, the design of the LAP-25 shows an acceptable result.
authors.affiliation: School of Jet Propulsion, Beihang University, China. xiaochen.yang.buaa@gmail.com
authors.forename: Xiao-Chen
authors.initials: XC
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xing-Min
authors.initials: XM
authors.lastname: Gui
authors.forename: Sheng-Shou
authors.initials: SS
authors.lastname: Hu
mesh_terms: D003198:Computer Simulation; D006353:Heart-Assist Devices; D006461:Hemolysis; D006801:Humans; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D016276:Ventricular Function