title: Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells.
abstract: Regulator of G-protein signaling protein (RGS)-2 is a modulator of anxiety and dysregulation of oxidative stress is implicated in anxiety. Also, RGS2 expression is reported to be induced by oxidative stress. Thus, if oxidative stress induces RGS2 expression and lack of RGS2 causes anxiety, then mechanisms that link RGS2 and oxidative stress potentially critical to anxiety must be revealed. Our study is the first to suggest role of RGS2 in regulation of enzymes involved in antioxidant defense namely glyoxalase-1 and glutathione reductase-1 via activation of p38 MAPK and PKC pathways in an Sp-1 dependent manner.
authors.affiliation: Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas, USA. ssalim@uh.edu
authors.forename: Samina
authors.initials: S
authors.lastname: Salim
authors.forename: Mohammad
authors.initials: M
authors.lastname: Asghar
authors.forename: Manish
authors.initials: M
authors.lastname: Taneja
authors.forename: Iiris
authors.initials: I
authors.lastname: Hovatta
authors.forename: Yuh-Lin
authors.initials: YL
authors.lastname: Wu
authors.forename: Kaustuv
authors.initials: K
authors.lastname: Saha
authors.forename: Nada
authors.initials: N
authors.lastname: Sarraj
authors.forename: Brian
authors.initials: B
authors.lastname: Hite
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015153:Blotting, Western; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D016373:DNA, Antisense / Q000235:genetics; D004789:Enzyme Activation / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects; D005980:Glutathione Reductase / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007791:Lactoylglutathione Lyase / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D050050:Protein Carbonylation / Q000187:drug effects; D011493:Protein Kinase C / Q000378:metabolism; D020710:RGS Proteins / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000187:drug effects; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016373:DNA, Antisense; D016877:Oxidants; D020710:RGS Proteins; C105345:Rgs2 protein, mouse; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D011493:Protein Kinase C; D048051:p38 Mitogen-Activated Protein Kinases; D007791:Lactoylglutathione Lyase