title: The 712A/G polymorphism of Brain-derived neurotrophic factor is associated with Parkinson's disease but not Major Depressive Disorder in a Chinese Han population.
abstract: BACKGROUND
  Overlaps in clinical, pathological and molecular characteristics of Parkinson's disease (PD) and Major Depressive Disorder (MD-D) have promoted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. Experimental and clinical data suggest that genetic variations in Brain-derived neurotrophic factor (BDNF) gene may increase the risk for PD and MD-D.
  
  
  METHODS
  Two hundred and sixty-six PD, 83 MD-D and 400 controls were recruited for this study, assessed using a battery of neuropsychological tests, and genotyped for 11757C/G, 712A/G, 196A/G, and 270C/T in BDNF gene.
  
  
  RESULTS
  712A/G was associated with 2.50-fold time risk of PD. By combining genotypes AG/AA with 712 GG genotype as reference (OR=1) in stratification analysis, AG/AA genotypes were associated with PD (OR=2.94, 95% CI=1.88-4.61). Accordingly, the A allele was significantly overrepresented in PD compared with the G allele (OR=3.16, 95% CI=2.08-4.81). This distribution in females and males were similar.
  
  
  CONCLUSIONS
  Our results suggested a novel association between BDNF 712A/G AG/AA genotypes and PD in a Chinese Han population.
authors.affiliation: Department of Medical Psychology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210029, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.forename: Suwan
authors.initials: S
authors.lastname: Guo
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Hua
authors.forename: Weiguo
authors.initials: W
authors.lastname: Liu
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002681:China; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D019208:Brain-Derived Neurotrophic Factor