title: Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels.
abstract: OBJECTIVE
  To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Academic and academically affiliated assisted reproductive technology (ART) programs.
  
  
  METHODS
  Seventy-three women undergoing ART with elevated early follicular FSH levels.
  
  
  METHODS
  None.
  
  
  METHODS
  Number of oocytes retrieved during ART cycle, number of day 3 embryos, and cycle cancellation and clinical pregnancy rates.
  
  
  RESULTS
  Random AMH levels were strongly correlated with the number of oocytes retrieved during an ART cycle among women with elevated FSH (r=0.55). Women with elevated FSH who had a random serum AMH level of 0.6 ng/mL or higher had twice the number of oocytes retrieved (11±1.3 vs. 5.6±0.6), a greater number of day 3 embryos (5.7±0.9 vs. 3±0.5), and approximately a third of the cycle cancellation rate (14% vs. 41%) compared with women with a random serum AMH below 0.6 ng/mL. The clinical pregnancy rate was also higher among women with a random serum AMH≥0.6 ng/mL (28% vs. 14%), however, the difference was not statistically significant.
  
  
  CONCLUSIONS
  A random serum AMH level is useful in setting expectations for ART prognosis in women with elevated early follicular-phase serum FSH levels.
authors.affiliation: Albert Einstein College of Medicine, Montefiore's Institute for Reproductive Medicine and Health, Bronx, New York 10461, USA. erbuyuk@yahoo.com
authors.forename: Erkan
authors.initials: E
authors.lastname: Buyuk
authors.forename: David B
authors.initials: DB
authors.lastname: Seifer
authors.forename: Joshua
authors.initials: J
authors.lastname: Younger
authors.forename: Richard V
authors.initials: RV
authors.lastname: Grazi
authors.forename: Harry
authors.initials: H
authors.lastname: Lieman
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000097:blood*; D005498:Follicular Phase / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D009518:New York; D054315:Oocyte Retrieval; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; D054304:Anti-Mullerian Hormone