title: Relationship between cardiac adrenergic image and exercise testing in heart failure.
abstract: BACKGROUND
  The exercise treadmill test can be used in ventricular dysfunction patients for functional capacity or predicting prognosis. The cardiac image with 123I MIBG shows cardiac sympathetic activation.
  
  
  OBJECTIVE
  To evaluate the relationship between exercise treadmill test variables and cardiac image changes in 123I MIBG.
  
  
  METHODS
  23 patients with LVEF ≤ 45% performed scintigraphy cardiac with 123I MIBG and divided into two groups. G1: Washout rate < 27%; G2: ≥ 27%. Systolic blood pressure (SBP), heart rate (HR) and functional capacity were evaluated. It was performed Student t test or Mann-Whitney U test, Spearman coefficient and linear regression.
  
  
  RESULTS
  SBP at exercise peak (G1: 181.00 ± 28.01; G2: 153.27 ± 27.71 mmHg, p = 0.027), SBP variation [G1: 64(47.5-80.5); G2: 36(25-47) mmHg, p = 0.015], the HR at exercise peak (G1: 136.91 ± 19.66; G2: 118.45 ± 13.98 bpm, p = 0.018) and chronotropic response (G1: 70.42 ± 17.94; G2: 49.47 ± 14.89%, p = 0.006), and functional capacity [G1: 8.37(6.47-10.27); G2: 4.42(2.46-6.38) METs, p = 0.003] were smaller in G2 group. There was negative correlation between Washout rate and SBP at exercise peak (r = -0.505, p = 0.014), variation in SBP (r = -0.493, p = 0.017) and functional capacity (r = -0.646, p = 0.001). Nevertheless, SBP at exercise peak (r = -0.422, p = 0.016) and functional capacity (r = -0.804, p = 0.004) were the only variables associated with Washout rate, after linear regression.
  
  
  CONCLUSIONS
  In heart failure patients, the SBP at exercise peak and functional capacity were the variables associated with Washout rate.
authors.affiliation: Universidade Federal Fluminense, Niterói, RJ, Brazil. lmessias@cardiol.br
authors.forename: Leandro
authors.initials: L
authors.lastname: Rocha Messias
authors.forename: Maria Ângela M
authors.initials: MÂ
authors.lastname: de Queiroz Carreira
authors.forename: Sandra Marina
authors.initials: SM
authors.lastname: Ribeiro de Miranda
authors.forename: Jader
authors.initials: J
authors.lastname: Cunha de Azevedo
authors.forename: Isabela
authors.initials: I
authors.lastname: Ambrósio Gava
authors.forename: Ronaldo
authors.initials: R
authors.lastname: Campos Rodrigues
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Maróstica
authors.forename: Antônio Claudio
authors.initials: AC
authors.lastname: Lucas da Nóbrega
authors.forename: Claudio
authors.initials: C
authors.lastname: Tinoco Mesquita
mesh_terms: D019797:3-Iodobenzylguanidine; D001794:Blood Pressure / Q000502:physiology; D005080:Exercise Test / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D018709:Statistics, Nonparametric
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine