title: Magnetic resonance imaging of amyloid plaques in transgenic mouse models of Alzheimer's disease.
abstract: A major objective in the treatment of Alzheimer's disease is amyloid plaque reduction. Transgenic mouse models of Alzheimer's disease provide a controlled and consistent environment for studying amyloid plaque deposition in Alzheimer's disease. Magnetic resonance imaging is an attractive tool for longitudinal studies because it offers non-invasive monitoring of amyloid plaques. Recent studies have demonstrated the ability of magnetic resonance imaging to detect individual plaques in living mice. This review discusses the mouse models, MR pulse sequences, and parameters that have been used to image plaques and how they can be optimized for future studies.
authors.affiliation: Center for Magnetic Resonance Research and Department of Radiology University of Minnesota Medical School, Minneapolis, Minnesota, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Chamberlain
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Wengenack
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Poduslo
authors.forename: Michael
authors.initials: M
authors.lastname: Garwood
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack