title: Targeting death receptor induced apoptosis and necroptosis: a novel therapeutic strategy to prevent neuronal damage in retinal detachment.
abstract: Retinal detachment (RD) is a common cause of human visual impairment. Detachment of photoreceptors from the retinal pigment epithelium causes photoreceptor loss and subsequent vision decline. Death receptor (DR)-induced apoptosis play critical role in activating apoptosis in photoreceptor cells. Z-VAD-FMK inhibits the DR-induced retinal neuronal apoptosis but promotes neuronal death through necroptosis pathway, an alternative programmed cell death, which can be inhibited by Nec-1. Thus, we may achieve a better result by simultaneous inhibition of DR-induced apoptosis and necroptosis, which provides us with a new direction in the treatment of RD.
authors.affiliation: Department of Ophthalmology, Affiliated First People's Hospital of Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: K
authors.initials: K
authors.lastname: Dong
authors.forename: X
authors.initials: X
authors.lastname: Sun
mesh_terms: D017209:Apoptosis; D006801:Humans; D009336:Necrosis; D009474:Neurons / Q000473:pathology*; D053218:Receptors, Death Domain / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D012163:Retinal Detachment / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D053218:Receptors, Death Domain