title: PI3K and chemotaxis: a priming issue?
abstract: Although the spatiotemporal activation of phosphoinositide 3-kinases (PI3Ks) at the leading edge of chemotaxing cells represents a key marker of polarity, both Dictyostelium discoideum and neutrophils lacking measurable PI3K activity can still migrate directionally under certain conditions. Evidence from various papers suggests that the differentiation state of cells or their priming status can consolidate otherwise contradictory findings.
authors.affiliation: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Philippe V
authors.initials: PV
authors.lastname: Afonso
authors.forename: Carole A
authors.initials: CA
authors.lastname: Parent
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology*; D004023:Dictyostelium / Q000166:cytology / Q000502:physiology; D006801:Humans; D009504:Neutrophils / Q000166:cytology / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D019869:Phosphatidylinositol 3-Kinases