title: Backscattering interferometry: an alternative approach for the study of hydrogen bonding interactions in organic solvents.
abstract: Intermolecular interactions involving hydrogen bonds are responsible for catalysis and recognition. Traditional methods used to study hydrogen-bonding interactions are generally limited to relatively large volumes and high substrate concentrations. Backscattering Interferometry (BSI) provides a microfluidic platform to study these interactions in nonaqueous media at micromolar to nanomolar concentrations in picoliter volumes by monitoring changes in the refractive index.
authors.affiliation: Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, United States.
authors.forename: Esther N
authors.initials: EN
authors.lastname: Pesciotta
authors.forename: Darryl J
authors.initials: DJ
authors.lastname: Bornhop
authors.forename: Robert A
authors.initials: RA
authors.lastname: Flowers
mesh_terms: D006860:Hydrogen Bonding; D007368:Interferometry / Q000379:methods; D044085:Microfluidics; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry*
chemical_list: D012997:Solvents