title: Rescue extracorporeal life support for acute verapamil and propranolol toxicity in a neonate.
abstract: Extracorporeal life support (ECLS) to manage acute antiarrhythmic drugs toxicity in neonates has never been reported. Here presented is a case of venoarterial extracorporeal membrane oxygenation support in a newborn with refractory low cardiac output as a result of acute Ca-channel and β-receptor antagonist toxicity for treatment of paroxysmal supraventricular tachycardia (SVT). Shortly after onset of ECLS, the baby recovered sinus rhythm and subsequent bouts of SVT were controlled by amiodarone infusion and repeated DC shocks. Weaning was possible on the 5th day after implant, once recovery of the left ventricular function and optimization of the antiarrhythmic medication were achieved. In neonates with severe but potentially reversible cardiac dysfunction caused by drug toxicity, ECLS can maintain cardiac output and vital organ perfusion while allowing time for drug redistribution, metabolism, and clearance.
authors.affiliation: Division of Cardiac Surgery, University of Verona, O.C.M. Piazzale Stefani 1, Verona, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: De Rita
authors.forename: Luca
authors.initials: L
authors.lastname: Barozzi
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Franchi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Faggian
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mazzucco
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Luciani
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000633:toxicity*; D002121:Calcium Channel Blockers / Q000633:toxicity*; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011433:Propranolol / Q000633:toxicity*; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*; D014700:Verapamil / Q000633:toxicity*
chemical_list: D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D011433:Propranolol; D014700:Verapamil