title: [Variability in blood pressure and arterial hypertension].
abstract: Blood pressure variability in hypertension is an independent risk factor of cardiovascular complications, especially of stroke. Antihypertensive drugs/classes with powerful antihypertensive effect and suppression of blood pressure variability might have additional impact on the cardiovascular risk in clinical practice. Current evidence suggests that calcium channel blockers (CCB) decrease blood pressure variability more than all other antihypertensive classes. Combination of CCB with ACE-inhibitors suppresses blood pressure variability more than diuretics plus beta-blockers. Within-visit blood pressure variability (measured as coefficient of standard deviation) seems to be relatively simple and strong predictor of stroke and cardiovascular events.
authors.affiliation: Centrum pro hypertenzi III. interní kliniky 1. Iékarské fakulty UK a VFN Praha. jwidi@lf1.cuni.cz
authors.forename: J
authors.initials: J
authors.lastname: Widimský
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002318:Cardiovascular Diseases; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers