title: Longitudinal change in renal function after radical nephrectomy in Japanese patients with renal cortical tumors.
abstract: OBJECTIVE
  We investigated the longitudinal change in renal function after radical nephrectomy in Japanese patients with renal cortical tumors and compared it with that after partial nephrectomy.
  
  
  METHODS
  This retrospective study included 416 Japanese patients who underwent radical (341) or partial (75) nephrectomy between 1994 and 2009. We investigated the postoperative duration of freedom from new onset of an estimated glomerular filtration rate of less than 60 and 45 ml/minute/1.73 m(2), and the longitudinal change in renal function after surgery.
  
  
  RESULTS
  The 3-year probability of freedom from new onset of an estimated glomerular filtration rate of less than 60 ml/minute/1.73 m(2) after radical and partial nephrectomy was 63% and 89%, respectively (p <0.001). The corresponding incidence of an estimated glomerular filtration rate of less than 45 ml/minute/1.73 m(2) was 89% and 95%, respectively (p = 0.247). The estimated glomerular filtration rate decreased by 36% and 13% 1 year after radical and partial nephrectomy, respectively. During the next 5-year followup the estimated glomerular filtration rate after radical nephrectomy slightly but significantly increased by 5% but after partial nephrectomy it did not change significantly.
  
  
  CONCLUSIONS
  Radical nephrectomy is an independent risk factor for new onset of an estimated glomerular filtration rate of less than 60 ml/minute/1.73 m(2) in Japanese patients. However, relatively few patients have new onset of an estimated glomerular filtration rate of less than 45 ml/minute/1.73 m(2) even after radical nephrectomy. In Japanese patients renal function deteriorates immediately after radical nephrectomy but improves slightly but significantly thereafter.
authors.affiliation: Department of Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan. mntykym.uro@tmd.ac.jp
authors.forename: Minato
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Fujii
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Iimura
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Saito
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Koga
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Masuda
authors.forename: Satoru
authors.initials: S
authors.lastname: Kawakami
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kihara
mesh_terms: D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D007680:Kidney Neoplasms / Q000601:surgery*; D009392:Nephrectomy / Q000379:methods*; D012189:Retrospective Studies