title: Measurement and comparison of T1 relaxation times in native and transplanted kidney cortex and medulla.
abstract: OBJECTIVE
  To measure and compare cortical and medullary T1 values in native and transplanted kidneys with a wide range of function as measured by estimated glomerular filtration rate (eGFR).
  
  
  METHODS
  A total of 27 subjects (12 native and 15 transplants) were studied. Two magnetic resonance imaging (MRI) exams of T1 measurement were performed on separate days for reproducibility study. Group-wise comparisons of renal T1 on day 1 were performed between subjects with native and transplanted kidneys and also between subjects based on an eGFR threshold of 60 mL/min/1.73 m(2).
  
  
  RESULTS
  Transplanted kidneys had higher cortical renal T1 (1183 ± 136 msec) than native kidneys (1057 ± 94 msec) with similar results in the medulla. Subjects with an eGFR < 60 mL/min/1.73 m(2) had higher renal T1 than subjects with an eGFR > 60 mL/min/1.73 m(2) (cortical T1: P < 0.0001; medullary T1: P = 0.008). Renal T1 was highly reproducible for both native and transplant groups (with percent differences less than 10%).
  
  
  CONCLUSIONS
  There are differences in cortical and medullary T1 between native and transplanted kidneys at different levels of function.
authors.affiliation: Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705-2275, USA. yhuang52@wisc.edu
authors.forename: Yin
authors.initials: Y
authors.lastname: Huang
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Sadowski
authors.forename: Nathan S
authors.initials: NS
authors.lastname: Artz
authors.forename: Songwon
authors.initials: S
authors.lastname: Seo
authors.forename: Arjang
authors.initials: A
authors.lastname: Djamali
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Grist
authors.forename: Sean B
authors.initials: SB
authors.lastname: Fain
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007672:Kidney Cortex / Q000473:pathology*; D007679:Kidney Medulla / Q000473:pathology*; D016030:Kidney Transplantation / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged