title: Palladium-catalyzed allylic C-H bond functionalization of olefins.
abstract: Transition metal-mediated carbon-hydrogen bond cleavage and functionalization is a mechanistically interesting and synthetically attractive process. One of the important cases is the removal of a allylic hydrogen from an olefin by a Pd" salt to yield a pi-allylpalladium complex, followed by nucleophilic attack to efficient produce allylic derivatives. In contrast to the well-known allylic acetoxylation of cyclohexene, the reaction of open-chain olefins is fairly poor until recent several years. Some palladium catalytic systems have been reported to achieve allylic C-H functionalization, including acetoxylation, amination and alkylation of terminal alkenes. In the most of cases, ligand is crucial to the success of the transformation. This review surveys the recent development of palladium-catalyzed allylic C-H functionalziation of alkenes. These results promise a significant increase in the scope of olefin transformation.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, 200032, China. gliu@mail.sioc.ac.cn
authors.forename: Guosheng
authors.initials: G
authors.lastname: Liu
authors.forename: Yichen
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000478:Alkylation; D000586:Amination; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D003516:Cycloparaffins / Q000138:chemical synthesis*; D006859:Hydrogen / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D003516:Cycloparaffins; D018942:Macrolides; D010165:Palladium; D006859:Hydrogen