title: Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi.
abstract: The antifungal activities of dihydrosanguinarine and dihydrochelerythrine, isolated from the leaves of Macleaya microcarpa, were evaluated on 12 plant pathogenic fungi; the two compounds exhibited the highest antifungal activity against Botrytis cinerea Pers. Among the 11 tested plant pathogenic fungi in vitro, the two compounds showed the highest antifungal activity against B. cinerea Pers, with 95.16% and 98.32% mycelial growth inhibition at 50 µg mL⁻¹, respectively. In addition, the two compounds inhibited spore germination in vitro in a concentration-dependent manner. They also showed potent protective and curative effects against Erysiphe graminis and B. cinerea in vivo. This is the first report on the antifungal activity of dihydrosanguinarine and dihydrochelerythrine against pathogenic plant fungi.
authors.affiliation: Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Science, Danzhou 571737, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Ying-Qian
authors.initials: YQ
authors.lastname: Liu
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D053119:Benzophenanthridines / Q000737:chemistry / Q000494:pharmacology*; D020171:Botrytis / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology*; D028101:Papaveraceae / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D053119:Benzophenanthridines; D007546:Isoquinolines; C524982:dihydrochelerythrine; C501843:dihydrosanguinarine