title: Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme.
abstract: Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9+2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.
authors.affiliation: Emory University School of Medicine, Department of Cell Biology, Atlanta, GA 30322, USA. mwirschell@gmail.com
authors.forename: Maureen
authors.initials: M
authors.lastname: Wirschell
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Yamamoto
authors.forename: Lea
authors.initials: L
authors.lastname: Alford
authors.forename: Avanti
authors.initials: A
authors.lastname: Gokhale
authors.forename: Anne
authors.initials: A
authors.lastname: Gaillard
authors.forename: Winfield S
authors.initials: WS
authors.lastname: Sale
mesh_terms: D000818:Animals; D054468:Axoneme / Q000201:enzymology* / Q000378:metabolism; D002923:Cilia / Q000201:enzymology* / Q000378:metabolism; D017124:Conserved Sequence; D006801:Humans; D009068:Movement; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry / Q000378:metabolism*; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011494:Protein Kinases; D010744:Phosphoric Monoester Hydrolases