title: Mixture of cis-3-hexenol and trans-2-hexenal attenuates behavioral and stress responses induced by 2,5-dihydro-2,4,5-trimethylthiazoline and electric footshock stress in rats.
abstract: Green odor (GO), a mixture of cis-3-hexenol and trans-2-hexenal, attenuates stress responses and anxiety to psychological stressors in rodents; however, it remains unknown whether GO affects behavioral and stress responses to risk-related olfactory stimuli and actual noxious stimuli. The present study investigated the effects of green odor on behavioral and plasma adrenocorticotropic hormone (ACTH) responses to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), a component of fox feces, and electric footshock (FS) stress. When rats were simultaneously exposed to TMT and GO, they showed decreases in immobility and plasma ACTH levels compared with TMT alone. GO exposure after TMT increased immobility, but blocked the elevation of plasma ACTH levels compared with rats exposed to distilled water after TMT. This means that GO presentation during TMT attenuated the TMT-induced behavioral response and GO presentation during and after TMT inhibited TMT-induced elevation of plasma ACTH levels. Furthermore, electric FS-induced plasma ACTH elevations were attenuated by simultaneous GO and FS exposure. GO presentation after FS attenuated plasma ACTH elevations and fecal responses. These findings reveal that GO has alleviating effects on olfactory stimulus- and noxious stimulus-induced behavioral and endocrinal responses.
authors.affiliation: Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nikaido
authors.forename: S
authors.initials: S
authors.lastname: Miyata
authors.forename: T
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000447:Aldehydes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001007:Anxiety / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D001522:Behavior, Animal / Q000187:drug effects*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004558:Electric Stimulation / Q000379:methods; D004609:Eliminative Behavior, Animal / Q000187:drug effects; D000441:Hexanols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D055696:Olfactory Perception / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: C411827:2,5-dihydro-2,4,5-trimethylthiazoline; D000447:Aldehydes; D014151:Anti-Anxiety Agents; D000441:Hexanols; D013844:Thiazoles; C051918:3-hexen-1-ol; C051750:2-hexenal; D000324:Adrenocorticotropic Hormone