title: [Ultrastructural changes and regeneration of the endocrine apparatus of the human gastric mucosal glandular epithelium in patients with chronic erosive gastritis].
abstract: The aim of this investigation was to study the structure and regeneration of the endocrine apparatus of the human gastric mucosal glandular epithelium. Using electron microscopy, the mucosal biopsy specimens obtained from 14 patients with chronic erosive Helicobacter pylori-associated gastritis, were studied. The most pronounced changes were seen both in the numbers and ultrastructure of G- and P-endocrinocytes. The changes were detected in the nucleus structure, endocrine granule and polysome content, and he mitochondrial structure. The regeneration of the endocrine cells took place through the differentiation of the committed precursors via the "agranular" cell stage, transformation of the exocrine cells into the endocrine ones, and as a result of the formation of the epithelial cords on the erosion surfaces that consisted of the cells in diverse differentiation stages (from the undifferentiated to specialized cells of all the endocrine and exocrine types).
authors.forename: V F
authors.initials: VF
authors.lastname: Ivanova
authors.forename: A A
authors.initials: AA
authors.lastname: Puzyrev
authors.forename: R V
authors.initials: RV
authors.lastname: Draĭ
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D055098:Endocrine Cells / Q000378:metabolism / Q000382:microbiology / Q000648:ultrastructure*; D005260:Female; D005752:Gastric Mucins / Q000378:metabolism / Q000648:ultrastructure*; D005756:Gastritis / Q000378:metabolism / Q000382:microbiology / Q000473:pathology* / Q000503:physiopathology; D016481:Helicobacter Infections / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism / Q000648:ultrastructure; D012038:Regeneration
chemical_list: D005752:Gastric Mucins