title: [Association between apolipoprotein A5 gene polymorphism and coronary heart disease in the Han population from Xinjiang].
abstract: OBJECTIVE
  The aim is to investigate the association between coronary heart disease (CHD) and c.553G>T polymorphism of apolipoprotein A5 (ApoA5) gene and the influence of serum lipid level in the Han ethnic population of Xinjiang.
  
  
  METHODS
  The polymorphism of ApoA5 gene in 486 patients with CHD and 501 controls was analyzed by methods of polymerase chain reaction and restriction fragment length polymorphism analysis. Level of serum lipid in each patient was detected at the same time.
  
  
  RESULTS
  There was significant difference in the distribution of genotypes between CHD group and controls group (χ(2)=8.757, P=0.013). Non-conditioned logistic regression analyses, after adjusted for age, gender, smoking, total serum cholesterol, presence of hypertension and diabetes, revealed that individuals who carried T allele (TT + GT genotype) had an increased risk of CHD, compared to GG genotype (OR=1.753, 95%CI: 1.030-2.983, P<0.05). There was also a remarkable difference noticed in the level of serum triglyceride by genotypes in CHD group and control group (t=-5.242, P<0.01; t=-3.499, P=0.001). Individuals in the two groups who carried T allele had higher level of serum triglyceride than those carried GG genotype. Individuals in CHD group who carried T allele had higher level of serum total cholesterol than those carried GG genotype (t=-2.465, P=0.014).
  
  
  CONCLUSIONS
  It seemed that the c.553G>T polymorphism of ApoA5 gene had influenced on the level of serum triglyceride and the total cholesterol among Han population in Xinjiang. c.553G>T polymorphism was associated with the development of CHD, while T allele might be an influencing risk factor on CHD.
authors.affiliation: Key Laboratory of Cardiovascular Disease Research of Xinjiang, Urumqi 830054, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Yuan
authors.forename: Yi-tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Yi-ning
authors.initials: YN
authors.lastname: Yang
authors.forename: Zhen-yan
authors.initials: ZY
authors.lastname: Fu
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Li
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Bang-dang
authors.initials: BD
authors.lastname: Chen
mesh_terms: D000368:Aged; D000483:Alleles; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A