title: Prevalence of any size adenomas and advanced adenomas in 40- to 49-year-old individuals undergoing screening colonoscopy because of a family history of colorectal carcinoma in a first-degree relative.
abstract: BACKGROUND
  Per current guidelines, patients with a first-degree relative (FDR) with colorectal cancer (CRC) should get screened at least at age 40. Data about the prevalence of adenomas and advanced adenomas (AAs) in these patients are lacking.
  
  
  OBJECTIVE
  To examine the prevalence of adenomas and AAs in 40- to 49-year-old individuals undergoing screening colonoscopy for family history of CRC.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  Asymptomatic patients 40 to 49 years of age undergoing their first screening colonoscopy at the University of Michigan during the period 1999 to 2009 because of an FDR with CRC.
  
  
  METHODS
  Prevalence of adenomas (any size), AAs, and risk factors associated with adenomas.
  
  
  RESULTS
  Among 640 study patients, the prevalence of adenomas (any size) was 15.4% and 3.3% for AAs. Adenoma prevalence was lower if the FDR with CRC was younger than 60 years of age versus an FDR with CRC older than 60 years of age (12.4% vs 19%, P = .034). Male sex (odds ratio 2.6; 95% CI, 1.06-4.4) and advancing age (odds ratio 1.16; 95% CI, 1.03-1.31) were associated with adenomas.
  
  
  CONCLUSIONS
  Limited data on risk factor exposure and insufficient sample size to assess risk factors for AAs.
  
  
  CONCLUSIONS
  Among 40- to 49-year-old patients undergoing screening colonoscopy because of an FDR with CRC, the prevalence of adenomas and AAs is low. Further research should determine whether these individuals have a higher prevalence of adenomas compared with average-risk individuals.
authors.affiliation: Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Akshay K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Jewel
authors.initials: J
authors.lastname: Samadder
authors.forename: Eric
authors.initials: E
authors.lastname: Elliott
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sethi
authors.forename: Philip
authors.initials: P
authors.lastname: Schoenfeld
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology*; D000328:Adult; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D008824:Michigan; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors