title: New sources of drugs for hematologic malignancies.
abstract: Advancing novel therapeutic agents for the treatment of malignancy into the marketplace is an increasingly costly and lengthy process. As such, new strategies for drug discovery are needed. Drug repurposing represents an opportunity to rapidly advance new therapeutic strategies into clinical trials at a relatively low cost. Known on-patent or off-patent drugs with unrecognized anticancer activity can be rapidly advanced into clinical testing for this new indication by leveraging their known pharmacology, pharmacokinetics, and toxicology. Using this approach, academic groups can participate in the drug discovery field and smaller biotechnology companies can "de-risk" early-stage drug discovery projects. Here, several scientific approaches used to identify drug repurposing opportunities are highlighted, with a focus on hematologic malignancies. In addition, a discussion of the regulatory issues that are unique to drug repurposing and how they impact developing old drugs for new indications is included. Finally, the mechanisms to enhance drug repurposing through increased collaborations between academia, industry, and nonprofit charitable organizations are discussed.
authors.affiliation: Princess Margaret Hospital, Ontario Cancer Institute, Toronto, ON, Canada.
authors.forename: Mahadeo A
authors.initials: MA
authors.lastname: Sukhai
authors.forename: Paul A
authors.initials: PA
authors.lastname: Spagnuolo
authors.forename: Scott
authors.initials: S
authors.lastname: Weir
authors.forename: James
authors.initials: J
authors.lastname: Kasper
authors.forename: Lavonne
authors.initials: L
authors.lastname: Patton
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Schimmer
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D055808:Drug Discovery / Q000191:economics / Q000379:methods* / Q000639:trends; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents