title: Impact of preterm PROM and its complications on long-term infant outcomes.
abstract: There is increasing evidence that preterm premature rupture of membranes (PPROM) is associated with increased risk for adverse neurodevelopmental outcomes through multiple mechanisms, including preterm birth and its antecedent etiologies. Intrauterine infection is a particularly important risk factor for adverse neurodevelopmental outcomes after PPROM. This review focuses on the long-term neurodevelopmental outcomes after PPROM, the possible etiologic mechanisms of neurological injury, and the effect of antenatal and perinatal interventions using available evidence.
authors.affiliation: Department of Obstetrics and Gynecology at University of Utah, Salt Lake City, Utah, USA. erin.clark@hsc.utah.edu
authors.forename: Erin A S
authors.initials: EA
authors.lastname: Clark
authors.forename: Michael
authors.initials: M
authors.lastname: Varner
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D016207:Cytokines / Q000009:adverse effects / Q000378:metabolism; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000378:metabolism; D008278:Magnesium Sulfate / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000209:etiology*; D011247:Pregnancy; D047928:Premature Birth; D011379:Prognosis; D013997:Time Factors; D015149:Tocolytic Agents / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D016207:Cytokines; D015149:Tocolytic Agents; D008278:Magnesium Sulfate