title: Ganodermasides C and D, two new anti-aging ergosterols from spores of the medicinal mushroom Ganoderma lucidum.
abstract: Two new anti-aging compounds, ganodermasides C and D, were isolated and their structures elucidated. They are novel ergosterols possessing a 4,6,8(14),22-tetraene-3-one unit with unique hydroxylation at C-9. Both of them significantly extended the replicative lifespan of the K6001 yeast strain. Ganodermasides C and D regulated the expression of the gene for UTH1 to prolong the replicative lifespan of yeast.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Yufang
authors.initials: Y
authors.lastname: Weng
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.forename: Lan
authors.initials: L
authors.lastname: Xiang
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuura
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qianming
authors.initials: Q
authors.lastname: Huang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Qi
mesh_terms: D000375:Aging / Q000187:drug effects*; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020940:Reishi / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000502:physiology; D013172:Spores, Fungal / Q000737:chemistry*
chemical_list: D004875:Ergosterol