title: Association of thyroid autoimmunity with acne in adult women.
abstract: BACKGROUND
  During the last decades an increase has been observed regarding acne in adults and especially women.
  
  
  OBJECTIVE
  To evaluate the association between thyroid disorder and the presence of post-adolescent acne in adult women, comparing with healthy controls.
  
  
  METHODS
  107 adult women with post-adolescent acne and 60 healthy controls were included. Complete blood count and standard biochemical profile of C-Reactive Protein (CRP) and levels of thyroid hormones and antibodies [triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), free T3 (FT3), free T4 (FT4), antithyroglobulin antibodies (anti-TG) and anti-thyroid peroxidase antibodies (anti-TPO)] were determined in all subjects of both the acne and control groups. A thyroid ultrasound was also performed.
  
  
  RESULTS
  There was a statistically significant difference (P=0.008) in the prevalence of positive anti-TG antibodies, with 25.2% of the acne group and 8.3% of the control group having elevated (>40 U/mL) anti-TG levels, respectively. Adult women with acne had a statistically significant increased relative risk to have high levels of anti-TG in comparison with healthy controls (odds ratio 3.89, P=0.011). This association was independent of age. Values for TSH, FT4, FT3, T4 and anti-TPO did not significantly differ between the two groups. No significant difference was found regarding the thyroid ultrasound findings. Although there was no significant difference between cases and controls regarding CRP levels, it is interesting that we observed a significant elevation in CRP in those acne patients who had positive antithyroglobulin antibodies.
  
  
  CONCLUSIONS
  It is likely that thyroid autoimmunity might be more frequent in the adult acne patients and this should be kept in mind when screening women with post-adolescent acne.
authors.affiliation: Department of Dermatology, A. Sygros Hospital, Athens University School of Medicine, Athens, Greece. siniavergou@gmail.com
authors.forename: T
authors.initials: T
authors.lastname: Vergou
authors.forename: E
authors.initials: E
authors.lastname: Mantzou
authors.forename: P
authors.initials: P
authors.lastname: Tseke
authors.forename: A E
authors.initials: AE
authors.lastname: Moustou
authors.forename: A
authors.initials: A
authors.lastname: Katsambas
authors.forename: M
authors.initials: M
authors.lastname: Alevizaki
authors.forename: C
authors.initials: C
authors.lastname: Antoniou
mesh_terms: D000152:Acne Vulgaris / Q000209:etiology / Q000276:immunology*; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D015551:Autoimmunity; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D013961:Thyroid Gland / Q000276:immunology*; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood
chemical_list: D001323:Autoantibodies; D013963:Thyroid Hormones; D013972:Thyrotropin; D002097:C-Reactive Protein