title: [Pineal gland melatonin-producing function in elderly patients with hypertensive disease: age peculiarities].
abstract: This work was aimed at study changes of the epiphyseal melatonin-producing function in elderly patients with hypertensive disease, as well as the relationships of those changes with the degree of arterial hypertension and 24-hour arterial pressure profile disorders. Examination of 18 young (20-34 years) and 20 elderly (60-74 years) healthy people has documented the decrease of melatonin-producing function in aging. In the group of 100 hypertensive disease patients, the nocturnal 6-hydro-oxymelatonin-sulafate (6-HMS) excretion was significantly lower (by 26.5%) than in their healthy age-matched individuals, thus evidencing for more pronounced disturbance of the melatonin-producing function in the former. It is noteworthy that lower melatonin-producing function of the epiphysis was revealed in the patients with the higher level of average 24-hour arterial pressure value and in the patients with a disturbed 24-hour arterial pressure profile "non-dippers".
authors.forename: V B
authors.initials: VB
authors.lastname: Shatilo
authors.forename: E V
authors.initials: EV
authors.lastname: Bondarenko
authors.forename: I A
authors.initials: IA
authors.lastname: Antoniuk-Shcheglova
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D008550:Melatonin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D008875:Middle Aged; D010870:Pineal Gland / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: C054513:6-sulfatoxymelatonin; D008550:Melatonin