title: Exercise, stress resistance, and central serotonergic systems.
abstract: Voluntary exercise reduces the incidence of stress-related psychiatric disorders in humans and prevents serotonin-dependent behavioral consequences of stress in rodents. Evidence reviewed herein is consistent with the hypothesis that exercise increases stress resistance by producing neuroplasticity at multiple sites of the central serotonergic system, which all help to limit the behavioral impact of acute increases in serotonin during stressor exposure.
authors.affiliation: Department of Integrative Physiology and Center for Neuroscience, University of Colorado-Boulder, CO, USA. ben.greenwood@colorado.edu
authors.forename: Benjamin N
authors.initials: BN
authors.lastname: Greenwood
authors.forename: Monika
authors.initials: M
authors.lastname: Fleshner
mesh_terms: D000818:Animals; D015444:Exercise / Q000502:physiology*; D006380:Helplessness, Learned; D006801:Humans; D008125:Locus Coeruleus / Q000502:physiology; D008297:Male; D051379:Mice; D009473:Neuronal Plasticity / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000502:physiology; D013315:Stress, Psychological / Q000523:psychology*
chemical_list: D012701:Serotonin