title: Effects of acute hepatic and renal failure on pharmacokinetics of flunixin meglumine in rats.
abstract: The aim of this study was to investigate the effects of hepatic and renal failure on the pharmacokinetics of flunixin in carbon tetrachloride (CCl(4))- and glycerol-treated rats. After intravenous administration of flunixin (2 mg/kg), the plasma concentration of flunixin was measured by high-performance liquid chromatography. Both acute hepatic and renal failure resulted in significantly increased area under the curve (AUC), prolonged elimination half-life (t(1/2β)), and reduced total body clearance (Cl(tot)) compared with respective controls (P<0.05). In conclusion, hepatic failure as well as renal failure modified the pharmacokinetics of flunixin.
authors.affiliation: Institute of Veterinary Science, Chungnam National University, 220 Gung-done, Yuseong-gu, 305-764 Daejeon, South Korea.
authors.forename: Youn-Hwan
authors.initials: YH
authors.lastname: Hwang
authors.forename: Hyo-In
authors.initials: HI
authors.lastname: Yun
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000378:metabolism*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002251:Carbon Tetrachloride; D003002:Clonixin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D005990:Glycerol; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C014558:flunixin meglumine; D002251:Carbon Tetrachloride; D005990:Glycerol; D003002:Clonixin