title: [Melatonin in the system of neurohormonal regulation in man. Part 1].
abstract: Part I of this systematic review is devoted to the history of melatonin (MT) studies, mechanisms of MT action, and its clinical importance as a universal modulator of physiological functions applicable to the treatment of numerous disorders, in the first place respiratory diseases. MT participates in regulation of arterial pressure and myocardial contractility, it increases antioxidative potential, plays an important role in regulation of circadian rhythms, sleep and adaptation to jet lag. Antioxidative, antitumorigenic, immunomodulatory, antidepressive, anti-anxiety, and hypnogenic activities of exogenous MT coupled to the absence of toxicity make it an attractive agent for the treatment of many human diseases especially in old age.
authors.forename: V I
authors.initials: VI
authors.lastname: Baksheev
authors.forename: N M
authors.initials: NM
authors.lastname: Kolomoets
mesh_terms: D002319:Cardiovascular System / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D008550:Melatonin / Q000502:physiology*; D009420:Nervous System / Q000378:metabolism*; D012137:Respiratory System / Q000378:metabolism*
chemical_list: D008550:Melatonin