title: Rhabdomyolysis-induced acute renal failure due to itraconazole and simvastatin association.
abstract: We present the case of an 82-year-old man admitted to our hospital for muscle weakness. He was under simvastatin 20 mg per day and was given pulse itraconazole therapy 8 days before the onset of symptoms for onychomycosis. He developed severe rhabdomyolysis inducing an acute renal failure necessitating renal replacement therapy. He eventually fully recovered. Given the possible concurrent use of simvastatin and itraconazole, awareness of this potential interaction is clinically important.
authors.affiliation: Intensive Care Department, Brugmann University Hospital, Brussels, Belgium.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Roques
authors.forename: Maria
authors.initials: M
authors.lastname: Lytrivi
authors.forename: Daniel
authors.initials: D
authors.lastname: Rusu
authors.forename: Jacques
authors.initials: J
authors.lastname: Devriendt
authors.forename: David
authors.initials: D
authors.lastname: De Bels
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D017964:Itraconazole / Q000009:adverse effects*; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000150:complications; D019821:Simvastatin / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017964:Itraconazole; D019821:Simvastatin