title: Toward more "ideal" polyketide natural product synthesis: a step-economical synthesis of zincophorin methyl ester.
abstract: A highly efficient and step-economical synthesis of zincophorin methyl ester has been achieved. The unprecedented step economy of this zincophorin synthesis is principally due to an application of the tandem silylformylation-crotylsilylation/Tamao oxidation-diastereoselective tautomerization reaction, which achieves in a single step what would typically require a significant multistep sequence.
authors.affiliation: Department of Chemistry, Columbia University, New York, New York 10027, USA.
authors.forename: Tyler J
authors.initials: TJ
authors.lastname: Harrison
authors.forename: Stephen
authors.initials: S
authors.lastname: Ho
authors.forename: James L
authors.initials: JL
authors.lastname: Leighton
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000191:economics*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D002264:Carboxylic Acids; D018942:Macrolides; C488419:zincophorin methyl ester