title: Intra-abdominal metastasis of an intracranial germinoma via ventriculo-peritoneal shunt in a 13-year-old female.
abstract: A 13-year-old patient presented with massive intra-abdominal metastasis and spontaneous acute tumour lysis syndrome, 17-months after VP shunt placement for metastatic pineal germinoma treated with cranio-spinal-irradiation. Hyperhydration/rasburicase improved renal function, allowing chemotherapy with subsequent surgery. The patient remains event-free 34-months later. Risk of intra-abdominal metastasis from VP shunts is discussed.
authors.affiliation: Department of Paediatric Haematology and Oncology, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. mjm16@cam.ac.uk
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Murray
authors.forename: Lucy E
authors.initials: LE
authors.lastname: Metayer
authors.forename: Conor L
authors.initials: CL
authors.lastname: Mallucci
authors.forename: Juliet P
authors.initials: JP
authors.lastname: Hale
authors.forename: James C
authors.initials: JC
authors.lastname: Nicholson
authors.forename: Ramez W
authors.initials: RW
authors.lastname: Kirollos
authors.forename: G A Amos
authors.initials: GA
authors.lastname: Burke
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001201:Ascites / Q000209:etiology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D018237:Germinoma / Q000175:diagnosis* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D009366:Neoplasm Seeding; D010871:Pinealoma / Q000175:diagnosis* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D015275:Tumor Lysis Syndrome / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents