title: Epidemiology of Transfusion Related Acute Lung Injury in France: Preliminary Results.
abstract: SUMMARY: The French Hemovigilance Network has been established in 1994 and records all adverse events associated with the transfusion of a labile blood products (LBP) regardless of their severity. From 1994 to 2006 35,423,172 LBP were issued, 85,812 adverse transfusion reactions notified, and 139 cases of transfusion related acute lung injury (TRALI) observed. The LBP most at risk is fresh frozen plasma (FFP), followed by platelets concentrates (PC) and packed red cells (PRC). However, because the use of FFP is not frequent in France, it only accounts for about 10% of TRALI, whereas PRC and PC are involved in the remaining cases. In no case, pooled FFP treated with solvent-detergent were involved. Patients' profiles are peculiar with a high disease burden. Therefore, targeting a prevention policy only on FFP would result in a marginal reduction of TRALI in France.
authors.affiliation: Unité d'Hémovigilance, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Renaudier
authors.forename: Syvie
authors.initials: S
authors.lastname: Schlanger
authors.forename: Mai-Phuong
authors.initials: MP
authors.lastname: Vo Mai
authors.forename: Nadra
authors.initials: N
authors.lastname: Ounnoughene
authors.forename: Pascal
authors.initials: P
authors.lastname: Breton
authors.forename: Stéphane
authors.initials: S
authors.lastname: Cheze
authors.forename: Albane
authors.initials: A
authors.lastname: Girard
authors.forename: Lisette
authors.initials: L
authors.lastname: Hauser
authors.forename: Jean François
authors.initials: JF
authors.lastname: Legras
authors.forename: Hélène
authors.initials: H
authors.lastname: Odent-Malaure
authors.forename: Danielle
authors.initials: D
authors.lastname: Rebibo
authors.forename: Chantal
authors.initials: C
authors.lastname: Waller
authors.forename: Béatrice
authors.initials: B
authors.lastname: Willaert
authors.forename: Cyril
authors.initials: C
authors.lastname: Caldani