title: [Plasticity of the cellular phenotype].
abstract: The tragical consequences of the Hiroshima and Nagasaki atomic bombs in 1945 were to lead to the discovery of hematopoietic stem cells and their phenotypic plasticity, in response to environmental factors. These concepts were much later extended to the founding cells of other tissues. In the following collection of articles, the mechanisms underlying this plasticity, at the frontiers of developmental biology and oncology, are illustrated in the case of various cell types of neural origin and of some tumours.
authors.affiliation: Laboratoire de Plasticité Gliale, Centre de Psychiatrie et Neurosciences, UMR-S 894/Inserm, Université Paris-Descartes, CHU Sainte Ann, 2 ter rue d'Alésia, 75014 Paris, France. Herve.Chneiweiss@inserm.fr
authors.forename: Hervé
authors.initials: H
authors.lastname: Chneiweiss
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D004777:Environment; D006412:Hematopoietic Stem Cells / Q000528:radiation effects; D006801:Humans; D007564:Japan; D009369:Neoplasms / Q000473:pathology; D009473:Neuronal Plasticity; D054043:Nuclear Weapons; D010641:Phenotype; D011832:Radiation Injuries; D013234:Stem Cells