title: Esophageal pH monitoring with the BRAVO capsule: experience in a single tertiary medical center.
abstract: OBJECTIVE
  The aim of the present study was to report the global experience with placement, complication rate, and recording of esophageal pH using the BRAVO capsule at our institution.
  
  
  METHODS
  We recorded the rate of any technical problems and complications during placement in all of the patients (ages 4-22 years) who received this device during a 2-year period. All of the patients undergoing esophagogastroduodenoscopy with the placement of BRAVO pH capsule were included in this analysis. We also examined the pH data recorded on days 1 and 2 for significant day-to-day variability during 2 days of pH monitoring.
  
  
  RESULTS
  Two hundred eighty-nine BRAVO pH probes were placed from January 1, 2006 to December 31, 2008. At least 1 day of data was obtained in 278 patients (96.2%). Two days of data were obtained in 274 patients (94.8%). Of all of the reported complications, 1% occurred before deployment of the capsule, 4% occurred during deployment of the capsule, and 9% occurred after successful deployment of the capsule. One patient experienced a superficial esophageal tear that was associated with failure of the capsule to release from the delivery system. No patient requested removal of the capsule and all of the capsules detached within 14 days. In 9.12% of our patients, reflux index was normal on day 1 and abnormal on day 2. There was no statistically significant difference between reflux index recorded on day 1 versus day 2 (P = 0.686).
  
  
  CONCLUSIONS
  The BRAVO pH capsule is easy to place, safe, and well tolerated by children. Performing a 48-hour study detected abnormal reflux in an additional 9% of our patients.
authors.affiliation: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Indiana University School of Medicine, Indianapolis, IN 46202, USA. jmcabrer@iupui.edu
authors.forename: José
authors.initials: J
authors.lastname: Cabrera
authors.forename: Miriam
authors.initials: M
authors.lastname: Davis
authors.forename: Debbie
authors.initials: D
authors.lastname: Horn
authors.forename: Marian
authors.initials: M
authors.lastname: Pfefferkorn
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Croffie
mesh_terms: D000293:Adolescent; D002214:Capsules; D002648:Child; D002675:Child, Preschool; D016145:Endoscopy, Digestive System / Q000379:methods; D050782:Esophageal pH Monitoring / Q000295:instrumentation*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D011446:Prospective Studies; D013686:Telemetry / Q000295:instrumentation* / Q000379:methods; D055815:Young Adult
chemical_list: D002214:Capsules