title: Serum levels of osteocalcin are inversely associated with the metabolic syndrome and the severity of coronary artery disease in Chinese men.
abstract: OBJECTIVE
  Osteocalcin is a bone-derived protein and has been shown to play an important role in regulating glucose and fat metabolism. We therefore investigated the association of serum levels of osteocalcin with the metabolic syndrome (MS) and coronary atherosclerosis in Chinese men.
  
  
  METHODS
  Serum osteocalcin levels were measured by an electrochemiluminescence immunoassay in 181 men who underwent coronary angiography, and their association with the MS and the severity of coronary artery disease (CAD) were studied.
  
  
  RESULTS
  Osteocalcin levels in patients with the MS were significantly lower compared with those in non-MS subjects (P < 0·001) and decreased correspondingly with the increasing number of components of the MS (P < 0·001). Multiple logistic regression analysis demonstrated that osteocalcin was independently associated with the MS (OR = 0·060, 95%CI: 0·005-0·651). In multiple stepwise regression analysis, waist circumference (P = 0·001) and fasting plasma glucose (P = 0·002) were independently associated with serum osteocalcin. Subgroup analysis in 60 subjects with normal glucose tolerance showed that serum osteocalcin decreased significantly in patients with CAD compared with those without CAD (P = 0·029) and decreased significantly as the number of stenotic vessels increased (P = 0·033). Furthermore, serum osteocalcin showed an independent correlation with coronary atherosclerosis index (standardized β = -0·497, P = 0·003).
  
  
  CONCLUSIONS
  Serum osteocalcin is inversely associated with the MS as well as the severity of coronary atherosclerosis in Chinese men, supporting the new concept that bone has the reciprocal regulation with energy metabolism.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.forename: Mi
authors.initials: M
authors.lastname: Zhou
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Lu
authors.forename: Huating
authors.initials: H
authors.lastname: Li
authors.forename: Ye
authors.initials: Y
authors.lastname: Wang
authors.forename: Leiqing
authors.initials: L
authors.lastname: Sun
authors.forename: Meifang
authors.initials: M
authors.lastname: Gao
authors.forename: Meng
authors.initials: M
authors.lastname: Wei
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis; D016723:Bone Remodeling; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D006801:Humans; D007118:Immunoassay; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D012044:Regression Analysis; D012720:Severity of Illness Index; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D015675:Osteocalcin