title: Dronedarone-induced digoxin toxicity: new drug, new interactions.
abstract: Dronedarone is a relatively new antiarrhythmic drug approved for paroxysmal or persistent atrial fibrillation. Dronedarone can inhibit P-glycoprotein-mediated digoxin clearance and increase steady-state digoxin level 2.5 times. It is important to closely monitor plasma digoxin levels or administer a lower loading dose of digoxin in patients taking dronedarone concomitantly. We report a case of digoxin toxicity in a patient taking concomitant dronedarone as a result of interaction between digoxin and dronedarone.
authors.affiliation: Department of Medicine, Maimonides Medical Center, Brooklyn, NY.
authors.forename: Ajay
authors.initials: A
authors.lastname: Vallakati
authors.forename: Preeti A
authors.initials: PA
authors.lastname: Chandra
authors.forename: Manali
authors.initials: M
authors.lastname: Pednekar
authors.forename: Robert
authors.initials: R
authors.lastname: Frankel
authors.forename: Jacob
authors.initials: J
authors.lastname: Shani
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000187:drug effects / Q000378:metabolism*; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy; D004077:Digoxin / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D000077764:Dronedarone; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000889:Anti-Arrhythmia Agents; D004077:Digoxin; D000077764:Dronedarone; D000638:Amiodarone