title: Teicoplanin pharmacokinetics during albumin dialysis.
abstract: Teicoplanin (TP) pharmacokinetics was assessed in a critically ill patient during albumin dialysis (AD), which was performed with the molecular adsorbent recirculating system. After a 1200-mg loading dose (24 mg/kg), doses of 1200 and 1000 mg (20 mg/kg) on day 2 and 3, respectively, were administered during two cycles of AD. The mean TP peak and trough concentrations amounted to 99.3 and 21.4 µg/mL, respectively, during AD. A mean half-life of 5.5 h, an apparent volume of distribution of 0.302 L/kg, and a mean total TP clearance of 39 mL/h/kg were calculated. Ninety minutes after the start of AD, the extracorporeal clearance was 3560 mL/h. Within 8 h of AD therapy, the serum concentrations decreased by about 75%. Despite a considerable elimination of TP by AD, therapeutic serum levels could be maintained during the entire treatment by administration of high doses and close monitoring of TP serum concentrations.
authors.affiliation: Clinical Pharmacokinetics Unit, Laboratory of Inflammation Research, Department of Internal Medicine I, Innsbruck Medical University, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Weiler
authors.forename: Gerda
authors.initials: G
authors.lastname: Falkensammer
authors.forename: Christoph
authors.initials: C
authors.lastname: Seger
authors.forename: Michael
authors.initials: M
authors.lastname: Joannidis
authors.forename: Romuald
authors.initials: R
authors.lastname: Bellmann
mesh_terms: D000328:Adult; D000418:Albumins / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000097:blood*; D016638:Critical Illness; D005260:Female; D006801:Humans; D006435:Renal Dialysis; D018805:Sepsis / Q000628:therapy; D017334:Teicoplanin / Q000097:blood*
chemical_list: D000418:Albumins; D000900:Anti-Bacterial Agents; D017334:Teicoplanin