title: Corneal invasion by hemangiosarcoma in a horse.
abstract: A 15-year-old gray Arabian gelding presented for evaluation of a lateral limbal mass extending across approximately 30% of the cornea. Grossly, the raised mass appeared nonpigmented, smooth, and irregular in shape, with an area of central necrosis and serosanguinous discharge. The mass was removed via lamellar keratectomy and histopathologic evaluation revealed features characteristic of hemangiosarcoma (HSA), including irregular vascular channels lined by a plump spindle cell population. Immunohistochemistry results showed that the neoplastic cells lining the vascular channels present diffuse and strong cytoplasmic reaction with von Willebrand Factor and the perivascular spindle cells exhibit moderate cytoplasmic reaction for smooth muscle actin. A lack of cytokeratin staining definitively excluded a diagnosis of atypical squamous cell carcinoma. Smooth muscle actin staining of the perivascular cells adjacent to the neoplastic endothelial cells is not a feature commonly described in HSA and has not been reported in previous cases of equine HSA. The horse remained in good health 21 months postkeratectomy and has exceeded the survival time of previously documented equine ocular HSA cases where more extreme surgical excision was performed.
authors.affiliation: Cornell University, College of Veterinary Medicine, Equine and Farm Animal Hospital, Ithaca, New York 14853-6401, USA. tpinndvm@gmail.com
authors.forename: Toby L
authors.initials: TL
authors.lastname: Pinn
authors.forename: Tim
authors.initials: T
authors.lastname: Cushing
authors.forename: Lorie Moore
authors.initials: LM
authors.lastname: Valentino
authors.forename: Seth A
authors.initials: SA
authors.lastname: Koch
mesh_terms: D000818:Animals; D005134:Eye Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D006394:Hemangiosarcoma / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D006734:Horse Diseases / Q000473:pathology* / Q000601:surgery; D006736:Horses; D008297:Male