title: Microparticles in stored red blood cells as potential mediators of transfusion complications.
abstract: This article reviews evidence for the involvement of cell-derived microparticles (MPs) in transfusion-related adverse events. The controversy concerning possible added risk of older versus fresher stored blood is also reviewed and is consistent with the hypothesis that MPs are involved with adverse events. Although all types of circulating MPs are discussed, the emphasis is on red blood cell-derived MPs (RMPs). The evidence is particularly strong for involvement of RMPs in transfusion-related acute lung injury, but also for postoperative thrombosis. However, this evidence is largely circumstantial. Work in progress to directly test the hypothesis is also briefly reviewed.
authors.affiliation: Wallace H. Coulter Platelet Laboratory, Division of Hematology and Oncology, Department of Medicine, University of Miami School of Medicine, Miami, Florida 33176, USA. wjy@med.miami.edu
authors.forename: Wenche
authors.initials: W
authors.lastname: Jy
authors.forename: Marco
authors.initials: M
authors.lastname: Ricci
authors.forename: Sherry
authors.initials: S
authors.lastname: Shariatmadar
authors.forename: Orlando
authors.initials: O
authors.lastname: Gomez-Marin
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Horstman
authors.forename: Yeon S
authors.initials: YS
authors.lastname: Ahn
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism*; D006801:Humans