title: Experience with patients with anti-MUSK antibody positive myasthenia gravis.
abstract: The association of muscle tyrosine kinase (Musk) antibody with recurrent bulbar weakness in acetylcholine receptor antibody (Ach-R Ab) negative myasthenia gravis (MG) has been well documented. We describe 2 patients, a middle aged man and a 9-year-old girl, both seronegative for Ach R antibody who had recurrent bulbar weakness and MUSK antibody positivity. Patients made a full recovery from the acute episode with intravenous immunoglobulin (IV Ig) therapy. The peculiar clinical features of this condition and its management are discussed.
authors.affiliation: Internal Medicine and Neurology Services, Lokmanya Tilak Municipal General Hospital and Medical College, Mumbai, India.
authors.forename: Uma
authors.initials: U
authors.lastname: Sundar
authors.forename: Preeti
authors.initials: P
authors.lastname: Shaunbhag
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Lakkas
authors.forename: Makardhwaj
authors.initials: M
authors.lastname: Shrivastava
authors.forename: Amit
authors.initials: A
authors.lastname: Shah
authors.forename: Meghana
authors.initials: M
authors.lastname: Vaidya
authors.forename: Dnyaneswar
authors.initials: D
authors.lastname: Asole
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000906:Antibodies / Q000097:blood*; D001323:Autoantibodies / Q000276:immunology / Q000627:therapeutic use; D002648:Child; D019818:Clavulanic Acid / Q000627:therapeutic use; D005152:Facial Muscles / Q000473:pathology; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology / Q000276:immunology; D009133:Muscular Atrophy / Q000209:etiology; D009157:Myasthenia Gravis / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000906:Antibodies; D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D011950:Receptors, Cholinergic; D019818:Clavulanic Acid; D000658:Amoxicillin; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases