title: Effects of oral supplementation of L-arginine in the treatment of pulmonary hypertension secondary to pulmonary embolism: a case report.
abstract: We tried L-arginine for the treatment of pulmonary hypertension secondary to pulmonary embolism. The plasma brain natriuretic peptide (BNP) level inversely correlated with the plasma concentration of L-arginine. After oral supplementation of L-arginine, patient's symptoms (shortness of breath and general malaise), state of congestive heart failure, and exercise capacity all improved. L-arginine may be effective in the treatment of pulmonary hypertension secondary to pulmonary embolism.
authors.affiliation: Pharmacy Fukushima Medical University Hospital, Fukushima, Japan. h-ogapi@fmu.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogata
authors.forename: Tomoko
authors.initials: T
authors.lastname: Takahashi
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Tosiyuki
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Maruyama
authors.forename: Machiko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Edo
mesh_terms: D000284:Administration, Oral; D001120:Arginine / Q000008:administration & dosage*; D019587:Dietary Supplements; D005260:Female; D006333:Heart Failure / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011655:Pulmonary Embolism / Q000150:complications*
chemical_list: D020097:Natriuretic Peptide, Brain; D001120:Arginine