title: LDL-cholesterol lowering activity of a blend of rice bran oil and safflower oil (8:2) in patients with hyperlipidaemia: a proof of concept, double blind, controlled, randomised parallel group study.
abstract: Cardiovascular diseases have emerged as major health burden worldwide in recent times. Low density lipoprotein cholesterol (LDL-C) serves as the primary marker for cardiovascular diseases. Reports suggest that rice bran oil has antihyperlipidaemic properties. However, current evidence suggests that no single oil can provide the recommended dietary fat ratio. Hence the present study was undertaken in patients with hyperlipidaemia to study effects of substitution of the cooking oil with a blend of 80% rice bran oil and 20% safflower oil on LDL-C levels. The selected patients (n = 73) were randomly assigned either to the study oil group (blend under study) or control oil group (the oil which the patient was using before). The lipid profile was monitored monthly in these patients for 3 months during which they consumed the oil as per the randomisation. At each follow up, LDL-C levels showed a significant reduction from baseline in the study oil group and reduction was more than that observed in the control group. It was also observed that the percentage of the respondents was higher in the study oil group. At the end of the study period, 82% patients from this group had LDL levels less than 150 mg% as against 57% in the control group. Thus, the substitution of usual cooking oil with a blend of rice bran oil and safflower oil (8:2) was found to exert beneficial effects on the LDL-C levels shifting them to low-risk lipid category.
authors.affiliation: Department of Pharmacology and Therapeutics, Seth GS Medical College and KEM Hospital, Mumbai 400012.
authors.forename: Harshad
authors.initials: H
authors.lastname: Malve
authors.forename: Prafulla
authors.initials: P
authors.lastname: Kerkar
authors.forename: Nidheesh
authors.initials: N
authors.lastname: Mishra
authors.forename: Sanjita
authors.initials: S
authors.lastname: Loke
authors.forename: N N
authors.initials: NN
authors.lastname: Rege
authors.forename: Ankita
authors.initials: A
authors.lastname: Marwaha-Jaspal
authors.forename: Kiran J
authors.initials: KJ
authors.lastname: Jainani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL / Q000187:drug effects*; D003296:Cooking; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010938:Plant Oils; D011446:Prospective Studies; D000073879:Rice Bran Oil; D012450:Safflower Oil; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D010938:Plant Oils; D012450:Safflower Oil; D000073879:Rice Bran Oil