title: Caged molecular beacons: controlling nucleic acid hybridization with light.
abstract: We have constructed a novel class of light-activatable caged molecular beacons (cMBs) that are caged by locking two stems with a photo-labile biomolecular interaction or covalent bond. With the cMBs, the nucleic acid hybridization process can be easily controlled with light, which offers the possibility for a high spatiotemporal resolution study of intracellular mRNAs.
authors.affiliation: State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
authors.forename: Chunming
authors.initials: C
authors.lastname: Wang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhu
authors.forename: Yanling
authors.initials: Y
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Lin
authors.forename: Chaoyong James
authors.initials: CJ
authors.lastname: Yang
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
mesh_terms: D001710:Biotin / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D007700:Kinetics; D008027:Light; D009693:Nucleic Acid Hybridization / Q000379:methods*; D010782:Photolysis; D011092:Polyethylene Glycols / Q000737:chemistry; D012333:RNA, Messenger / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D012333:RNA, Messenger; D011092:Polyethylene Glycols; D001710:Biotin