title: Drug resistance: a periplasmic ménage à trois.
abstract: The paradigm tripartite efflux transporter AcrA-AcrB-TolC confers multiple drug resistance to Escherichia coli. Tikhonova et al. (2011) now examine how the three components connect to unity and highlight the critical role of AcrA membrane proximal domain conformation for successful assembly.
authors.affiliation: Institute of Biochemistry and Cluster of Excellence Frankfurt-Macromolecular Complexes, Goethe-University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Oswald
authors.forename: Klaas M
authors.initials: KM
authors.lastname: Pos