title: Two-dimensional gel electrophoresis in peritoneal fluid samples identifies differential protein regulation in patients suffering from peritoneal or ovarian endometriosis.
abstract: Endometriosis is determined by local and systemic proinflammatory dysregulation and therefore differential protein expression in peritoneal fluid (PF). Of highest interest is lesion formation and the establishment and persistence of endometriosis. In this study we analyzed well-characterized PF samples of patients with ovarian or peritoneal endometriosis and compared them to control samples. We found 11 proteins differentially regulated, of which some might play a key role in the pathogenesis of endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Medical Faculty of RWTH Aachen University, Aachen, Germany. mwoelfler@ukaachen.de
authors.forename: Monika M
authors.initials: MM
authors.lastname: Wölfler
authors.forename: Ivo M
authors.initials: IM
authors.lastname: Meinhold-Heerlein
authors.forename: Linda
authors.initials: L
authors.lastname: Söhngen
authors.forename: Werner
authors.initials: W
authors.lastname: Rath
authors.forename: Ruth
authors.initials: R
authors.lastname: Knüchel
authors.forename: Joseph
authors.initials: J
authors.lastname: Neulen
authors.forename: Nicolai
authors.initials: N
authors.lastname: Maass
authors.forename: Corinna
authors.initials: C
authors.lastname: Henkel
mesh_terms: D000293:Adolescent; D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D015180:Electrophoresis, Gel, Two-Dimensional; D004715:Endometriosis / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D005858:Germany; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000175:diagnosis / Q000378:metabolism*; D010532:Peritoneal Diseases / Q000175:diagnosis / Q000378:metabolism*; D011506:Proteins / Q000032:analysis*; D040901:Proteomics / Q000379:methods*; D053719:Tandem Mass Spectrometry; D055815:Young Adult
chemical_list: D015415:Biomarkers; D011506:Proteins