title: Parametric images of myocardial viability using a single 15O-H2O PET/CT scan.
abstract: Perfusable tissue index (PTI) is a marker of myocardial viability and requires acquisition of transmission, (15)O-CO, and (15)O-H(2)O scans. The aim of this study was to generate parametric PTI images from a (15)O-H(2)O PET/CT scan without an additional (15)O-CO scan.
  
  
  METHODS
  Data from 20 patients undergoing both (15)O-H(2)O and (15)O-CO scans were used, assessing correlation between PTI based on (15)O-CO (PTI(CO)) and on fitted blood volume fractions (PTI(Vb)). In addition, parametric PTI(Vb) images of 10 patients undergoing (15)O-H(2)O PET/CT scans were generated using basis-function methods and compared with PTI(Vb) obtained using nonlinear regression. Simulations were performed to study the effects of noise on PTI(Vb).
  
  
  RESULTS
  Correlation between PTI(CO) and PTI(Vb) was high (r(2) = 0.73). Parametric PTI(Vb) correlated well with PTI(Vb) obtained using nonlinear regression (r(2) = 0.91). Simulations showed low sensitivity to noise (coefficient of variation < 10% at 20% noise).
  
  
  CONCLUSIONS
  Parametric PTI images can be generated from a single (15)O-H(2)O PET/CT scan.
authors.affiliation: Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands. h.harms@vumc.nl
authors.forename: Hendrik J
authors.initials: HJ
authors.lastname: Harms
authors.forename: Stefan
authors.initials: S
authors.lastname: de Haan
authors.forename: Paul
authors.initials: P
authors.lastname: Knaapen
authors.forename: Cornelis P
authors.initials: CP
authors.lastname: Allaart
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Lammertsma
authors.forename: Mark
authors.initials: M
authors.lastname: Lubberink
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014022:Tissue Survival; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014867:Water
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water