title: Enantioselective total synthesis of (+)-asteriscanolide via Rh(I)-catalyzed [(5+2)+1] reaction.
abstract: The total synthesis of (+)-asteriscanolide starting from two commercially available materials has been accomplished in 19 steps with a 3.8% overall yield. The key reaction is a chiral ene-vinylcyclopropane substrate induced Rh(I)-catalyzed [(5+2)+1] cycloaddition that efficiently constructs the [6.3.0] carbocyclic core with complete asymmetric induction.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry, Peking University, Beijing 100871, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liang
authors.forename: Xing
authors.initials: X
authors.lastname: Jiang
authors.forename: Zhi-Xiang
authors.initials: ZX
authors.lastname: Yu