title: Correlation between pretreatment or follow-up CT findings and therapeutic effect of autologous peripheral blood stem cell transplantation for interstitial pneumonia associated with systemic sclerosis.
abstract: OBJECTIVE
  To evaluate what is useful among various parameters including CT findings, laboratory parameters (%VC, %DLco, KL-6), patients related data (age, sex, duration of disease) to discriminate between responder and non-responder in patients who received autologous peripheral blood stem cell transplantation (auto-PBSCT) for interstitial pneumonia (IP) with systemic sclerosis (SSc).
  
  
  METHODS
  Auto-PBSCT and follow-up of at least one year by chest CT, serum KL-6, %VC, and %DLco were performed in 15 patients for IP with SSc. Analyzed CT findings included extent of ground-glass opacity (GGO), intralobular reticular opacity, number of segments that showed traction bronchiectasis, and presence of honeycombing. We regarded the therapeutic response of patients as responders when TLC or VC increase over 10% or DLco increase more than 15%, otherwise we have classified as non-responder. We applied univariate and multivariate analyses to find the significant indicators to discriminate responders from non-responders. P<0.05 was considered statistically significant.
  
  
  RESULTS
  Univariate and multivariate analyses showed that the significant parameter to discriminate responders from non-responders were pretreatment KL-6, presence of honeycombing, extent of GGO, and early change in extent of GGO. Among them, extent of GGO and early change in extent of GGO were the strongest discriminators between responders and non-responders (P=0.001, 0.001, respectively).
  
  
  CONCLUSIONS
  Several CT findings and pretreatment KL-6 may be useful to discriminate between responder and non-responder in patients who received auto-PBSCT for IP with SSc.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. yabuuchi@shs.kyushu-u.ac.jp
authors.forename: Hidetake
authors.initials: H
authors.lastname: Yabuuchi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: Shunya
authors.initials: S
authors.lastname: Sunami
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamitani
authors.forename: Shuji
authors.initials: S
authors.lastname: Sakai
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Hatakenaka
authors.forename: Koji
authors.initials: K
authors.lastname: Nagafuji
authors.forename: Takahiko
authors.initials: T
authors.lastname: Horiuchi
authors.forename: Mine
authors.initials: M
authors.lastname: Harada
authors.forename: Koichi
authors.initials: K
authors.lastname: Akashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016015:Logistic Models; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome