title: Evaluation of Rosa damascena mouthwash in the treatment of recurrent aphthous stomatitis: a randomized, double-blinded, placebo-controlled clinical trial.
abstract: OBJECTIVE
  As the exact etiology of recurrent aphthous stomatitis remains unknown, its treatment has primarily been palliative to relieve the pain, associated inflammation, and duration of the lesions by using antibacterial mouthrinses, analgesics, and immunomodulators. Nevertheless, no treatment has been universally effective in management of recurrent aphthous stomatitis, which necessitates the search for novel therapeutic agents. The aim of this study was to assess the clinical efficacy of the aqueous extract of Rosa damascena, which has reported anti-inflammatory and antinociceptive properties, in the treatment of recurrent aphthous stomatitis.
  
  
  METHODS
  This was a randomized, double-blind, placebo-controlled investigation. Fifty patients were enrolled in this 2-week study; the clinical efficacy of the mouthwash on pain, size, and number of ulcers in the test group was compared with that of the placebo group on days 4, 7, 11, and 14.
  
  
  RESULTS
  There were no statistically significant differences between baseline parameters. However, statistical analysis indicated a significant difference on days 4 and 7 between the placebo and test groups for all parameters.
  
  
  CONCLUSIONS
  This study showed that mouthwash containing Rosa damascena extract was more effective than the placebo in the treatment of recurrent aphthous stomatitis.
authors.affiliation: Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Vakilabad Blvd, Mashhad, Iran. hoseinpourh@mums.ac.ir
authors.forename: Hassan
authors.initials: H
authors.lastname: Hoseinpour
authors.forename: Sean A F
authors.initials: SA
authors.lastname: Peel
authors.forename: Hassan
authors.initials: H
authors.lastname: Rakhshandeh
authors.forename: Ali
authors.initials: A
authors.lastname: Forouzanfar
authors.forename: Morteza
authors.initials: M
authors.lastname: Taheri
authors.forename: Omid
authors.initials: O
authors.lastname: Rajabi
authors.forename: Mostafa
authors.initials: M
authors.lastname: Saljoghinejad
authors.forename: Keyvan
authors.initials: K
authors.lastname: Sohrabi
mesh_terms: D000328:Adult; D000700:Analgesics / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D010147:Pain Measurement; D008517:Phytotherapy / Q000379:methods*; D010919:Placebos; D010936:Plant Extracts / Q000627:therapeutic use*; D012008:Recurrence; D027826:Rosa; D013281:Stomatitis, Aphthous / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects; D055815:Young Adult
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009067:Mouthwashes; D010919:Placebos; D010936:Plant Extracts