title: Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease.
abstract: Cognitively normal (NL) individuals with a maternal history of late-onset Alzheimer's disease (MH) show reduced brain glucose metabolism on FDG-PET as compared to those with a paternal history (PH) and those with negative family history (NH) of Alzheimer's disease (AD). This FDG-PET study investigates whether metabolic deficits in NL MH are associated with advancing maternal age at birth. Ninety-six NL individuals with FDG-PET were examined, including 36 MH, 24 PH, and 36 NH. Regional-to-whole brain gray matter standardized FDG uptake value ratios were examined for associations with parental age across groups using automated regions-of-interest and statistical parametric mapping. Groups were comparable for clinical and neuropsychological measures. Brain metabolism in AD-vulnerable regions was lower in MH compared to NH and PH, and negatively correlated with maternal age at birth only in MH. There were no associations between paternal age and metabolism in any group. Evidence for a maternally inherited, maternal age-related mechanism provides further insight on risk factors and genetic transmission in late-onset AD.
authors.affiliation: New York University School of Medicine, New York, NY 10016, USA. lisa.mosconi@nyumc.org
authors.forename: Lisa
authors.initials: L
authors.lastname: Mosconi
authors.forename: Wai
authors.initials: W
authors.lastname: Tsui
authors.forename: John
authors.initials: J
authors.lastname: Murray
authors.forename: Pauline
authors.initials: P
authors.lastname: McHugh
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Schantel
authors.initials: S
authors.lastname: Williams
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pirraglia
authors.forename: Lidia
authors.initials: L
authors.lastname: Glodzik
authors.forename: Susan
authors.initials: S
authors.lastname: De Santi
authors.forename: Shankar
authors.initials: S
authors.lastname: Vallabhajosula
authors.forename: Mony J
authors.initials: MJ
authors.lastname: de Leon
mesh_terms: D000328:Adult; D032721:Adult Children; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D009035:Mothers; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012307:Risk Factors