title: Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling.
abstract: Transforming growth factor-β (TGF-β) ligands and bone morphogenetic proteins (BMPs) play myriad roles in many biological processes and diseases. Their pluripotent activities are subject to multiple levels of regulation, including receptor oligomerization, endocytosis, association with co-receptors, cellular scaffolds or membrane domains, as well as transcriptional control. In this review, we focus on TGF-β and BMP receptor homomeric and heteromeric complex formation and their modulation by ligand binding, which regulate signaling on a near-immediate timescale. We discuss the current structural, biochemical and biophysical evidence for the oligomerization of these receptors, and the potential roles of distinct oligomeric interactions in signaling.
authors.affiliation: Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Ehrlich
authors.forename: Daniel
authors.initials: D
authors.lastname: Horbelt
authors.forename: Barak
authors.initials: B
authors.lastname: Marom
authors.forename: Petra
authors.initials: P
authors.lastname: Knaus
authors.forename: Yoav I
authors.initials: YI
authors.lastname: Henis
mesh_terms: D052004:Bone Morphogenetic Protein Receptors / Q000737:chemistry*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D036681:Fluorescence Recovery After Photobleaching / Q000379:methods; D005786:Gene Expression Regulation; D006801:Humans; D008024:Ligands; D010766:Phosphorylation; D011485:Protein Binding; D055503:Protein Multimerization; D018125:Receptors, Transforming Growth Factor beta / Q000737:chemistry*; D015398:Signal Transduction; D015533:Transcriptional Activation; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D019485:Bone Morphogenetic Proteins; D008024:Ligands; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D052004:Bone Morphogenetic Protein Receptors