title: Considerations in membrane resealing after preterm PROM.
abstract: Current management of preterm premature rupture of the membranes centers around the expectant management with antibiotics and steroid therapy. Membrane rupture seems to be the result of a mechanical event. Studying the physical properties of the membranes may help to gain understanding of the nature and causes of membrane rupture. This article reviews membrane mechanics, advances in membrane healing, and strategies in the prevention of membrane rupture. The physiologic mechanisms that lead to membrane rupture have not yet been fully elucidated. Models that test the biomechanics of the membranes should be used to develop strategies for repair or prevention.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, Delaware Center for Maternal Fetal Medicine, Christiana Hospital, Newark, Delaware, USA.
authors.forename: Vanita Dharan
authors.initials: VD
authors.lastname: Jain
authors.forename: Anthony
authors.initials: A
authors.lastname: Sciscione
mesh_terms: D000818:Animals; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D013718:Tensile Strength / Q000502:physiology; D014014:Tissue Adhesives / Q000627:therapeutic use; D014945:Wound Healing / Q000502:physiology*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives