title: Reporting of myelotoxicity associated with emerging regimens for the treatment of selected solid tumors.
abstract: In this article, we reviewed and quantified reporting of the risk of myelotoxicity, specifically febrile neutropenia (FN), and the related use of supportive care with colony-stimulating factor (CSF) or antibiotics in clinical trials published between January 2005 and June 2009, evaluating emerging regimens for the treatment of selected solid tumors. Our analysis showed that clinically significant neutropenia and neutropenia-related events were generally described in the studies evaluated (grade 3/4 neutropenia incidence, 72%; FN incidence, 53%). However, use of CSF and antibiotics was infrequently and inconsistently reported (trials reporting prophylactic CSF and antibiotics use: in the methods section, 38% and 10%, respectively; in the results section, 19% and 1%, respectively). These results highlight the need for a standardized approach to reporting neutropenic outcomes and use of supportive care measures. This can assist clinicians in prospectively managing relevant toxicities associated with these emerging regimens and thereby facilitate their safe and effective use in clinical practice.
authors.affiliation: Mount Medical Centre, 41, 146 Mounts Bay Rd, Perth, Western Australia 6000, Australia. arlenechan@me.com
authors.forename: Arlene
authors.initials: A
authors.lastname: Chan
authors.forename: Shailendra
authors.initials: S
authors.lastname: Verma
authors.forename: Sibylle
authors.initials: S
authors.lastname: Loibl
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Crawford
authors.forename: Mi Rim
authors.initials: MR
authors.lastname: Choi
authors.forename: Lyndah
authors.initials: L
authors.lastname: Dreiling
authors.forename: Ted
authors.initials: T
authors.lastname: Vandenberg
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced* / Q000209:etiology