title: Facilitation of bacterial adaptation to chlorothalonil-contaminated sites by horizontal transfer of the chlorothalonil hydrolytic dehalogenase gene.
abstract: Horizontal transfer of the chlorothalonil hydrolytic dehalogenase gene (chd) is proposed based on the high conservation of the chd gene and its close association with a novel insertion sequence, ISOcsp1, in 16 isolated chlorothalonil-dechlorinating strains belonging to eight different genera. The ecological role of horizontal gene transfer is assumed to facilitate bacterial adaptation to chlorothalonil-contaminated sites, through detoxification of chlorothalonil to less toxic 2,4,5-trichloro-6-hydroxybenzene-1,3-dicarbonitrile.
authors.affiliation: Department of Microbiology, Key Lab of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, 210095 Nanjing, Jiangsu, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liang
authors.forename: Guangli
authors.initials: G
authors.lastname: Wang
authors.forename: Yanfu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.forename: Shunpeng
authors.initials: S
authors.lastname: Li
authors.forename: Jiandong
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000220:Adaptation, Biological; D001419:Bacteria / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism*; D001711:Biotransformation; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D022761:Gene Transfer, Horizontal; D006867:Hydrolases / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D009570:Nitriles / Q000378:metabolism*; D017422:Sequence Analysis, DNA
chemical_list: D004269:DNA, Bacterial; D009570:Nitriles; D006867:Hydrolases; C005806:tetrachloroisophthalonitrile