title: In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes.
abstract: Conventional reactions of the versatile multidentate ligand 5-methyl-1,2,4-triazolo[1,5-a] pyrimidin-7(4H)-one (HmtpO) with metallic(II) perchlorate salts lead to three novel multidimensional complexes [Cu(HmtpO)(2)(H(2)O)(3)](ClO(4))(2)·H(2)O (1), {[Cu(HmtpO)(2)(H(2)O)(2)](ClO(4))(2) ·2HmtpO}(n) (2) and {[Co(HmtpO)(H(2)O)(3)](ClO(4))(2)·2H(2)O}(n) (3). We have tested the antiparasital activity in vitro and in vivo of the three new complexes against Trypanosoma cruzi showing very promising results and overcoming clearly the reference drug commonly used for the Chagas disease treatment, benznidazole.
authors.affiliation: Departamento de Química Inorgánica, Universidad de Granada, Severo Ochoa s/n, Granada, Spain.
authors.forename: Ana B
authors.initials: AB
authors.lastname: Caballero
authors.forename: Clotilde
authors.initials: C
authors.lastname: Marín
authors.forename: Antonio
authors.initials: A
authors.lastname: Rodríguez-Diéguez
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Ramírez-Macías
authors.forename: Elisa
authors.initials: E
authors.lastname: Barea
authors.forename: Manuel
authors.initials: M
authors.lastname: Sánchez-Moreno
authors.forename: Juan M
authors.initials: JM
authors.lastname: Salas
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy; D002522:Chlorocebus aethiops; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D005260:Female; D008024:Ligands; D051379:Mice; D008807:Mice, Inbred BALB C; D046529:Microscopy, Electron, Transmission; D009593:Nitroimidazoles / Q000737:chemistry; D010472:Perchlorates / Q000737:chemistry; D011744:Pyrimidinones / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D009593:Nitroimidazoles; D010472:Perchlorates; D011744:Pyrimidinones; D014230:Triazoles; D014344:Trypanocidal Agents; C494474:perchlorate; C009999:benzonidazole