title: New insights into the pathogenesis and treatment of Waldenstrom macroglobulinemia.
abstract: OBJECTIVE
  Waldenstrom macroglobulinemia is a distinct low-grade lymphoproliferative disease. There have been recent significant advances in understanding the underlying pathogenesis of this disease, including genetic and epigenetic regulators of tumor progression.
  
  
  RESULTS
  Current studies have shown that the tumor microenvironment plays a critical role in cell proliferation, dissemination, and drug resistance.
  
  
  CONCLUSIONS
  This review provides an update of the advances in the pathogenesis of factors both intrinsic (in the tumor clone) and extrinsic (in the bone marrow microenvironment) that regulate tumor progression in Waldenstrom macroglobulinemia. We next discuss novel agents that have been recently tested in clinical trials based on the advances observed in the pathogenesis of Waldenstrom macroglobulinemia.
authors.affiliation: Medical Oncology, Pharmacy Department, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Ghayas C
authors.initials: GC
authors.lastname: Issa
authors.forename: Houry
authors.initials: H
authors.lastname: Leblebjian
authors.forename: Aldo M
authors.initials: AM
authors.lastname: Roccaro
authors.forename: Irene M
authors.initials: IM
authors.lastname: Ghobrial
mesh_terms: D057890:Epigenomics; D006801:Humans; D008258:Waldenstrom Macroglobulinemia / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000628:therapy*