title: Reversible brain death after cardiopulmonary arrest and induced hypothermia.
abstract: OBJECTIVE
  To describe a patient with transient reversal of findings of brain death after cardiopulmonary arrest and attempted therapeutic hypothermia.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Intensive care unit of an academic tertiary care hospital.
  
  
  METHODS
  A 55-yr-old man presented with cardiac arrest preceded by respiratory arrest. Cardiopulmonary resuscitation was performed, spontaneous perfusion restored, and therapeutic hypothermia was attempted for neural protection. After rewarming to 36.5°C, neurologic examination showed no eye opening or response to pain, spontaneous myoclonic movements, sluggishly reactive pupils, absent corneal reflexes, and intact gag and spontaneous respirations. Over 24 hrs, remaining cranial nerve function was lost. The neurologic examination was consistent with brain death. Apnea test and repeat clinical examination after a duration of 6 hrs confirmed brain death. Death was pronounced and the family consented to organ donation. Twenty-four hrs after brain death pronouncement, on arrival to the operating room for organ procurement, the patient was found to have regained corneal reflexes, cough reflex, and spontaneous respirations. The care team faced the challenge of offering an adequate explanation to the patient's family and other healthcare professionals involved.
  
  
  METHODS
  Induced hypothermia and brain death determination.
  
  
  RESULTS
  This represents the first published report in an adult patient of reversal of a diagnosis of brain death made in full adherence to American Academy of Neurology guidelines. Although the reversal was transient and did not impact the patient's prognosis, it impacted his eligibility for organ donation and cast doubt about the ability to determine irreversibility of brain death findings in patients treated with hypothermia after cardiac arrest.
  
  
  CONCLUSIONS
  We strongly recommend caution in the determination of brain death after cardiac arrest when induced hypothermia is used. Confirmatory testing should be considered and a minimum observation period after rewarming before brain death testing ensues should be established.
authors.affiliation: Department of Neurology, Neuroscience Critical Care, Emory University School of Medicine, Atlanta, GA, USA. awebb03@emory.edu
authors.forename: Adam C
authors.initials: AC
authors.lastname: Webb
authors.forename: Owen B
authors.initials: OB
authors.lastname: Samuels
mesh_terms: D001926:Brain Death / Q000175:diagnosis*; D016887:Cardiopulmonary Resuscitation; D006323:Heart Arrest / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged