title: Cutaneous metastases in neonates: a review.
abstract: Two hundred eight neonates with malignant tumors and cutaneous metastases were reviewed. Malignancies most often associated with cutaneous metastases, in order of rank, were leukemia, multisystem Langerhans cell histiocytosis, neuroblastoma, rhabdoid tumor, rhabdomyosarcoma, primitive neuroectodermal tumor, choriocarcinoma, and adrenocortical carcinoma. Bluish skin nodules producing the "blueberry muffin baby"-like appearance were the most common dermatologic finding in 171, or 82% of 208 neonates. The tendency of newborns to present with skin nodules is one of the significant differences between malignancies in younger and older children. Patients with rhabdoid tumor and rhabdomyosarcoma had the lowest survival rates, 4% and 15%, respectively, compared with leukemia, 37.5%, and neuroblastoma, 58%. Overall survival was 39%.
authors.affiliation: Department of Pathology, Rady Children's Hospital San Diego, San Diego, California 92123, USA. hisaacs@ucsd.edu
authors.forename: Hart
authors.initials: H
authors.lastname: Isaacs
mesh_terms: D002822:Choriocarcinoma / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D017254:Leukemic Infiltration / Q000473:pathology*; D009447:Neuroblastoma / Q000473:pathology*; D017599:Neuroectodermal Tumors / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000473:pathology*; D012878:Skin Neoplasms / Q000556:secondary*