title: Cannabinoid system and cyclooxygenases inhibitors.
abstract: BACKGROUND
  The cannabinoid system consists of a complex array of receptors, substances with agonist/antagonist properties for those receptors, biosynthetic machineries and mechanisms for cellular uptake and degradation for endocannabinoids. This system is in interrelation with other systems that comprise lipid mediators like prostaglandins/leukotrienes systems. A clear antagonist, additive or synergic effect of nonsteroidal anti-inflammatory drugs (NSAIDs)-cannabinoid associations was not yet demonstrated. Aim. The present study tried to summarize the existent data on NSAIDS-cannabinoid system interactions.
  
  
  RESULTS
  A bibliographic research in Medline, Scirus, Embase was made using as keywords cannabinoid, nonsteroidal anti-inflammatory drugs, aspirin, ibuprofen, flurbiprofen, diclofenac, indomethacin, acetaminophen, coxibs, antinociceptive, antinociception, analgesia
  
  
  CONCLUSIONS
  A systematization of the results focusing on the NSAIDs drugs interaction with the cannabinoid system was presented. Out of all the substances analyzed in the present review, acetaminophen was studied the most regarding its interferences with the cannabinoid system, mainly due to contradictory results.
  
  
  CONCLUSIONS
  Some NSAIDs have additional influences on the cannabinoid system either by inhibiting fatty acid amide hydrolase (FAAH) or by inhibiting a possible intracellular transporter of endocannabinoids. All the NSAIDs that inhibit COX2 can influence the cannabinoid system because a possible important degradative pathway for anandamide and 2-arachidonoyl glycerol might involve COX 2. One of the causes for the variety of experimental results presented might be due to pharmacokinetic mechanisms, depending on the route of administration and the dose
authors.affiliation: Department of Pharmacology and Pharmacotheraphy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. phpaunescu@yahoo.com
authors.forename: H
authors.initials: H
authors.lastname: Păunescu
authors.forename: O A
authors.initials: OA
authors.lastname: Coman
authors.forename: L
authors.initials: L
authors.lastname: Coman
authors.forename: I
authors.initials: I
authors.lastname: Ghiţă
authors.forename: S R
authors.initials: SR
authors.lastname: Georgescu
authors.forename: F
authors.initials: F
authors.lastname: Drăghia
authors.forename: I
authors.initials: I
authors.lastname: Fulga
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism*; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D063385:Cannabinoid Receptor Modulators; D016861:Cyclooxygenase Inhibitors