title: Palladium-catalyzed hydrofunctionalization of vinyl phenol derivatives with heteroaromatics.
abstract: A hydroheteroarylation reaction of vinyl phenols using an alkyl chloride as the sacrificial hydride source is reported. The method tolerates a wide range of heterocycles as the exogenous nucleophile including indoles and pyrroles. The resulting products are easily processed to biologically relevant scaffolds.
authors.affiliation: Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
authors.forename: Tejas P
authors.initials: TP
authors.lastname: Pathak
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Sigman
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D010636:Phenols; D011758:Pyrroles; D014753:Vinyl Compounds; D010165:Palladium