title: Comparison of chromosomal aberrations in primary colorectal carcinomas to their pulmonary metastases.
abstract: Pulmonary metastases (PM) are frequent in colorectal carcinoma (CRC). However, little is known about the chromosomal imbalances in CRC that accompany metastatic pulmonary disease. We investigated tumor specimens of CRC (n=30) and their corresponding PM by comparative genomic hybridization (CGH). There were no substantial differences in the degree of chromosomal instability between CRC and PM, neither in average number of copy alterations (ANCA; 6.6 ± 0.8 and 7.7 ± 0.9) nor in gains (2.6 ± 0.5 and 2.6 ± 0.4), losses (3.6 ± 0.5 and 4.8 ± 0.6), or amplifications (0.4 ± 0.1 and 0.3 ± 0.1). Basically, similar patterns of chromosomal imbalances could be identified in both CRC and corresponding PM, most frequently including chromosomal gains at 7, 8q, 13q, and 20q, as well as losses at 4, 8p, 18q, and 20p. CRC and corresponding PM differed in frequencies for losses at chromosome arm 5q (3 vs. 26%; P=0.012). Losses at 4q and 11q in CRC were significantly associated with lower 5-year survival rates (80 vs. 24%, P=0.026 and 74 vs. 17%, P=0.007, respectively), and they may represent candidates for adverse prognostic markers in primary CRC.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University Medical Center of Göttingen, Germany. bdanner@med.uni-goettingen.de
authors.forename: Bernhard C
authors.initials: BC
authors.lastname: Danner
authors.forename: Jan S
authors.initials: JS
authors.lastname: Gerdes
authors.forename: Klaus
authors.initials: K
authors.lastname: Jung
authors.forename: Björn
authors.initials: B
authors.lastname: Sander
authors.forename: Christina
authors.initials: C
authors.lastname: Enders
authors.forename: Torsten
authors.initials: T
authors.lastname: Liersch
authors.forename: Ralf
authors.initials: R
authors.lastname: Seipelt
authors.forename: Angelika
authors.initials: A
authors.lastname: Gutenberg
authors.forename: Bastian
authors.initials: B
authors.lastname: Gunawan
authors.forename: Friedrich A
authors.initials: FA
authors.lastname: Schöndube
authors.forename: Laszlo
authors.initials: L
authors.lastname: Füzesi
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D055028:Comparative Genomic Hybridization / Q000379:methods; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000556:secondary*; D008297:Male; D008875:Middle Aged