title: Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach.
abstract: Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts.
authors.affiliation: Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Araya
authors.forename: Huaping
authors.initials: H
authors.lastname: Zhang
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Prisinzano
authors.forename: Lester A
authors.initials: LA
authors.lastname: Mitscher
authors.forename: Barbara N
authors.initials: BN
authors.lastname: Timmermann
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D002396:Catechols / Q000737:chemistry* / Q000302:isolation & purification; D005233:Fatty Alcohols / Q000737:chemistry* / Q000302:isolation & purification; D020939:Zingiber officinale / Q000737:chemistry*; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D011687:Purines / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry*
chemical_list: D002396:Catechols; D005233:Fatty Alcohols; D011687:Purines; D006139:Guaiacol; C007845:gingerol; D000225:Adenine; C030985:purine