title: Filovirus vaccines.
abstract: Filoviruses can cause severe and often fatal hemorrhagic fever in humans and non-human primates (NHPs). Although there are currently no clinically proven treatments for filovirus disease, much progress has been made in recent years in the discovery of therapeutics and vaccines against these viruses. A variety of vaccine platforms have been shown to be effective against filovirus infection. This review summarizes the literature in this field, focusing on vaccines that have been shown to protect NHPs from infection. Furthermore, the uses of rodent models in vaccine development, as well as correlates of immunity, are discussed.
authors.affiliation: United States Army Medical Research Institute of Infectious Diseases, National Interagency Biodefense Campus; Fort Detrick, Frederick, MD, USA.
authors.forename: Steven B
authors.initials: SB
authors.lastname: Bradfute
authors.forename: John M
authors.initials: JM
authors.lastname: Dye
authors.forename: Sina
authors.initials: S
authors.lastname: Bavari
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002986:Clinical Trials as Topic; D016563:Filoviridae / Q000276:immunology*; D018702:Filoviridae Infections / Q000517:prevention & control; D005822:Genetic Vectors; D006801:Humans; D014611:Vaccination; D019444:Vaccines, DNA / Q000276:immunology; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*; D014771:Virion / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D019444:Vaccines, DNA; D014765:Viral Vaccines