title: Can the contra-lateral limb be used as a control with respect to analyses of bone remodelling?
abstract: Bone loss may result from remodelling initiated by implant stress protection. Quantifying remodelling requires bone density distributions which can be obtained from computed tomography scans. Pre-operative scans of large animals however are rarely possible. This study aimed to determine if the contra-lateral bone is a suitable control for the purpose of quantifying bone remodelling. CT scans of 8 pairs of ovine tibia were used to determine the likeness of left and right bones. The deviation between the outer surfaces of the bone pairs was used to quantify geometric similarity. The density differences were determined by dividing the bones into discrete volumes along the shaft of the tibia. Density differences were also determined for fractured and contra-lateral bone pairs to determine the magnitude of implant related remodelling. Left and right ovine tibiae were found to have a high degree of similarity with differences of less than 1.0mm in the outer surface deviation and density difference of less than 5% in over 90% of the shaft region. The density differences (10-40%) as a result of implant related bone remodelling were greater than left-right differences. Therefore, for the purpose of quantifying bone remodelling in sheep, the contra-lateral tibia may be considered an alternative to a pre-operative control.
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, 4059 Brisbane, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Krishnakanth
authors.forename: B
authors.initials: B
authors.lastname: Schmutz
authors.forename: R
authors.initials: R
authors.lastname: Steck
authors.forename: S
authors.initials: S
authors.lastname: Mishra
authors.forename: M A
authors.initials: MA
authors.lastname: Schütz
authors.forename: D R
authors.initials: DR
authors.lastname: Epari
mesh_terms: D000818:Animals; D015519:Bone Density; D016723:Bone Remodeling; D012015:Reference Standards; D012756:Sheep; D013977:Tibia / Q000000981:diagnostic imaging* / Q000502:physiology* / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000592:standards*