title: Interaction of DNA and a series of aromatic donor-viologen acceptor molecules with and without the presence of CB[8].
abstract: A series of 1-ethyl-1'-arylmethyl-4,4'-bipyridinium compounds is synthesized, where the aryl is phenyl (BEV), 2-naphthyl (NEV), 2-anthracenyl (AEV) or 1-pyrenyl (PEV). Among them, PEV and AEV can bind with calf thymus DNA mainly through intercalation and groove-binding modes, and both of them can be observed to photocleave plasmid pBR 322 DNA significantly under irradiation with a xenon arc lamp. After inclusion of cucurbit[8]uril (CB[8]), all of the aromatic donor-viologen acceptor compounds exhibit efficient DNA photocleavage ability. The reason is that CB[8] can inhibit the intramolecular backwards electron transfer in the aromatic donor-viologen acceptor molecule, prolonging the lifetime of the charge separated excited state to some extent. These studies bring a new subject in DNA photocleavage research and a potential application of the host-guest supramolecular system.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, E 224 West Campus, 2 Linggong, Road, Dalian, 116024, China.
authors.forename: Tongyan
authors.initials: T
authors.lastname: Zhang
authors.forename: Shiguo
authors.initials: S
authors.lastname: Sun
authors.forename: Fengyu
authors.initials: F
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Pang
authors.forename: Jiangli
authors.initials: J
authors.lastname: Fan
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Peng
mesh_terms: D000818:Animals; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage; D007093:Imidazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010782:Photolysis; D014755:Viologens / Q000737:chemistry*; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D004247:DNA; D007093:Imidazoles; D014755:Viologens; C507198:cucurbit(8)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils; C427203:calf thymus DNA