title: Nocardioazines: a novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits P-glycoprotein.
abstract: An Australian marine sediment-derived isolate, Nocardiopsis sp. (CMB-M0232), yielded a new class of prenylated diketopiperazine, indicative of the action of a uniquely regioselective diketopiperazine indole prenyltransferase. The bridged scaffold of nocardioazine A proved to be a noncytotoxic inhibitor of the membrane protein efflux pump P-glycoprotein, reversing doxorubicin resistance in a multidrug resistant colon cancer cell.
authors.affiliation: Institute for Molecular Bioscience, The University of Queensland , St. Lucia, Queensland 4072, Australia.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Raju
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Piggott
authors.forename: Xiao-Cong
authors.initials: XC
authors.lastname: Huang
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Capon
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000192:Actinomycetales / Q000737:chemistry*; D001315:Australia; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004122:Dimethylallyltranstransferase / Q000378:metabolism*; D004317:Doxorubicin / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000187:drug effects; D008386:Marine Biology; D008958:Models, Molecular
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D054659:Diketopiperazines; C559562:nocardioazine A; C559563:nocardioazine B; D004317:Doxorubicin; D004122:Dimethylallyltranstransferase