title: Synthesis of β- and γ-carbolines via ruthenium and rhodium catalysed [2+2+2] cycloadditions of yne-ynamides with methylcyanoformate.
abstract: A flexible approach towards substituted β- and γ-carbolines based on transition metal catalysed [2+2+2] cycloaddition reactions between functionalised yne-ynamides and methylcyanoformate is described. The versatility of this new reaction sequence is demonstrated by its application in the total synthesis of the marine natural product eudistomin U.
authors.affiliation: University of Mainz, Mainz, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Nissen
authors.forename: Vincent
authors.initials: V
authors.lastname: Richard
authors.forename: Carole
authors.initials: C
authors.lastname: Alayrac
authors.forename: Bernhard
authors.initials: B
authors.lastname: Witulski
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002243:Carbolines / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D005561:Formates / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D002243:Carbolines; D005561:Formates; C030544:formic acid; C088110:eudistomin U; C055572:gamma-carboline; D012428:Ruthenium; D012238:Rhodium