title: Synthesis and antimicrobial activity of some novel dicationic sulphonophanes.
abstract: The synthesis of some novel imidazole-based dicationic sulfonophanes incorporating various spacer units is described. All the sulphonophanes exhibit good antibacterial and antifungal activity against five bacterial strains Bacillus subtilis, Staphylococcus aureus, Vibrio cholera, Escherichia coli, Proteus vulgaris and human pathogenic fungus Candida albicans.
authors.affiliation: Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India. perumalrajakumar@gmail.com
authors.forename: Perumal
authors.initials: P
authors.lastname: Rajakumar
authors.forename: Chinnadurai
authors.initials: C
authors.lastname: Satheeshkumar
authors.forename: Gunasekaran
authors.initials: G
authors.lastname: Mohanraj
authors.forename: Narayanasamy
authors.initials: N
authors.lastname: Mathivanan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002412:Cations; D002939:Ciprofloxacin / Q000494:pharmacology; D003022:Clotrimazole / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D011514:Proteus vulgaris / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology; D014734:Vibrio cholerae / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002412:Cations; D007093:Imidazoles; D013450:Sulfones; D002939:Ciprofloxacin; D003022:Clotrimazole