title: A multicenter study on extramammary Paget's disease in Korea.
abstract: BACKGROUND
  There has been little research on extramammary Paget's disease (EMPD) conducted in Asia.
  
  
  METHODS
  The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period.
  
  
  RESULTS
  As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180 months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%).
  
  
  CONCLUSIONS
  In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
authors.affiliation: Department of Dermatology, Kyungpook National University, Daegu, Korea.
authors.forename: Seok-Jong
authors.initials: SJ
authors.lastname: Lee
authors.forename: Yoon Seok
authors.initials: YS
authors.lastname: Choe
authors.forename: Hong Dae
authors.initials: HD
authors.lastname: Jung
authors.forename: Sung Ku
authors.initials: SK
authors.lastname: Ahn
authors.forename: Young Chang
authors.initials: YC
authors.lastname: Cha
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Cho
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Choi
authors.forename: Kee Yang
authors.initials: KY
authors.lastname: Chung
authors.forename: Chang Hun
authors.initials: CH
authors.lastname: Huh
authors.forename: Il Hwan
authors.initials: IH
authors.lastname: Kim
authors.forename: Ki-Ho
authors.initials: KH
authors.lastname: Kim
authors.forename: Moon Bum
authors.initials: MB
authors.lastname: Kim
authors.forename: Myung Hwa
authors.initials: MH
authors.lastname: Kim
authors.forename: You Chan
authors.initials: YC
authors.lastname: Kim
authors.forename: Jee Bum
authors.initials: JB
authors.lastname: Lee
authors.forename: Mi Woo
authors.initials: MW
authors.lastname: Lee
authors.forename: Min-Geol
authors.initials: MG
authors.lastname: Lee
authors.forename: Weon Ju
authors.initials: WJ
authors.lastname: Lee
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Shin
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Shin
authors.forename: Kee Suck
authors.initials: KS
authors.lastname: Suh
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Won
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015580:Mohs Surgery / Q000379:methods; D015337:Multicenter Studies as Topic; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D010145:Paget Disease, Extramammary / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult