title: Improved surface-enhanced Raman scattering on micro-scale Au hollow spheres: synthesis and application in detecting tetracycline.
abstract: Au nanoparticles (NPs) forming a Au shell are coated on the surfaces of Ni microparticles (MPs) through a simple redox-transmetalation reaction, forming Ni/Au core-shell MPs. Then Au hollow spheres (HSs) are prepared by etching the Ni core in 1 mol L(-1) HCl solution. Surface-enhanced Raman scattering (SERS) spectroscopy signals of typical analytes such as rhodamine 6G (R6G) are observed on micro-scale Au HSs, even though the concentration of the analyte is as low as 10(-15) mol L(-1) (R6G). The Au HSs are also applied to detect tetracycline (TC), and a strong SERS signal is observed with the TC concentration of 0.1 μg L(-1). The quantitative analysis can be performed at 1595 and 1320 cm(-1), and a good linear response is also obtained. This work provides a potential and unique technique to detect broad-spectrum polyketide antibiotics in the future, and the detection of TC in foods and milk can also be performed using this SERS-based Au HSs substrate, which will benefit human health.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science & Engineering, University of Science and Technology of China, Hefei, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Qian-Wang
authors.initials: QW
authors.lastname: Chen
authors.forename: Nan
authors.initials: N
authors.lastname: Yan
authors.forename: Hui
authors.initials: H
authors.lastname: Wang