title: [Surface properties and characteristics of PU-PTHF/MDI/HPC poly(ether)urethane for cardiovascular prosthesis].
abstract: The polyurethanes are very used materials for medical devices. Their segmented block-copolymeric structures endows them a wide range of versatility in terms of tailoring their physical properties, and tissue compatibility.
  
  
  METHODS
  A new polyether-urethane based material (PU-PTHF/MDI/HPC) was studied on bio-integration capacity in cardiovascular applications. In this respect, surface and bulk structure analysis, albumin and fibrinogen adsorption (in noncompetitive and competitive condition) and thrombogenicity have been evaluated. It was found that PU-PTHF/MDI/HPC surfaces had different roughness and bulk interconnected, well developed porous structure. As protein adsorption properties, preferential adsorption for albumin of material was observed.
  
  
  RESULTS
  Thus, 0.280 +/- 0.04 mg/cm2 and 0.260+0.01 mg/ cm2 of albumin adsorb on PU-PTHF/MDI/HPC in noncompetitive and competitive conditions, while fibrinogen adsorption was 0.044 +/- 0.02 mg/cm2 and 0.040 +/- 0.01 mg/cm2. The clot amount test experiment have shown that clot weight of control blood was 24.8 +/- 2.03 mg, the clot weight formed by polyurethane was 28.4 +/- 2.93 mg and the clot weight formed by thrombogenic positive control (collagen membrane) was 42.5 +/- 3.50 mg.
  
  
  CONCLUSIONS
  From our study we could conclude: 1--PU-PTHF/MDI/HPC polyurethane membranes have two-interface structure that could be advantageous for cavitary or tubular medical devices; 2--the protein adsorption results and clot formation test revealed a thromboresistent behavior of PU-PTHF/MDI/HPC, appropriate for cardiovascular applications.
authors.affiliation: Facultatea de Bioinginerie Medicală, Disciplina de Biologie celulară si moleculară,Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi.
authors.forename: Maria
authors.initials: M
authors.lastname: Butnaru
authors.forename: Cristina-Daniela
authors.initials: CD
authors.lastname: Dimitriu
authors.forename: Doina
authors.initials: D
authors.lastname: Macocinschi
mesh_terms: D000327:Adsorption; D000465:Algorithms; D001672:Biocompatible Materials / Q000737:chemistry; D004864:Equipment and Supplies; D006350:Heart Valve Prosthesis; D006801:Humans; D008422:Materials Testing / Q000379:methods; D008567:Membranes, Artificial; D058105:Polymerization; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry*; D013314:Stress, Mechanical; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011140:Polyurethanes; C115016:polyetherurethane