title: Amelioration of systemic lupus erythematosus by Withangulatin A in MRL/lpr mice.
abstract: We have previously reported the anti-inflammatory potential and the possible underlying mechanisms of Withangulatin A (WA), which is an active component isolated from Physalis angulata L. Here, we demonstrated that WA might improve the life quality, as well as reduced the accumulation of proteinuria symptoms and levels of anti-double-stranded DNA antibodies in MRL/lpr mice. Moreover, WA could improve renal histopathologic characteristics of MRL/lpr mice. Intriguingly, expression of B cell-activating factor (BAFF), BAFF-R and related gene in the spleen were significantly reduced in 10 mg/kg WA-treated mice compared with that in 5 mg/kg WA-treated mice and untreated mice. These findings indicate that WA might have a pleiotropic therapeutic effect through their immunosuppression via inhibiting BAFF signaling, which suggest a potential application of this active constituent in the treatment of SLE.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Sun
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Mingcang
authors.initials: M
authors.lastname: Chen
authors.forename: Renqian
authors.initials: R
authors.lastname: Zhong
authors.forename: Jianwen
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood; D053264:B-Cell Activating Factor / Q000235:genetics / Q000378:metabolism; D053265:B-Cell Activation Factor Receptor / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D005921:Glomerulonephritis / Q000178:diet therapy / Q000209:etiology / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D051379:Mice; D019463:Mice, Inbred MRL lpr; D009929:Organ Size; D011283:Pregnenes / Q000627:therapeutic use*; D011507:Proteinuria / Q000188:drug therapy / Q000209:etiology; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D013163:Splenomegaly / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear; D053264:B-Cell Activating Factor; D053265:B-Cell Activation Factor Receptor; D011283:Pregnenes; C486662:Tnfrsf13c protein, mouse; C505720:Tnfsf13b protein, mouse; C059043:withangulatin A