title: The life cycle of centrioles.
abstract: Centrioles organize the centrosome and nucleate the ciliary axoneme, and the centriole life cycle has many parallels to the chromosome cycle. The centriole cycle in animals begins at fertilization with the contribution of two centrioles by the male gamete. In the ensuing cell cycles, the duplication of centrioles is controlled temporally, spatially, and numerically. As a consequence of the duplication mechanism, the two centrioles in a typical interphase cell are of different ages and have different functions. Here, we discuss how new centrioles are assembled, what mechanisms limit centriole number, and the consequences of the inherent asymmetry of centriole duplication and segregation.
authors.affiliation: Department of Biology, Stanford University, Stanford, California 94305, USA.
authors.forename: E
authors.initials: E
authors.lastname: Hatch
authors.forename: T
authors.initials: T
authors.lastname: Stearns
mesh_terms: D000818:Animals; D002502:Centrioles / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D013997:Time Factors