title: [MicroRNAs in pathophysiology of renal disease: an increasing interest].
abstract: MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs, evolutionarily conserved, that post-transcriptionnaly regulate gene expression by promoting degradation or repressing translation of the targetted messenger RNA. Recent data suggest the implication of miRNAs in renal development, and in renal diseases pathophysiology including fibrogenesis, regulation of innate and adaptive immunity, autoimmune diseases and acute rejection of the renal allograft. Herein, we review the implication of miRNAs in renal pathophysiology.
authors.affiliation: Inserm UMR-S775, Université René Descartes, Centre universitaire des Saints- Pères, 45, rue des Saints-Pères, 75006, Paris, France.
authors.forename: Lucile
authors.initials: L
authors.lastname: Amrouche
authors.forename: Raja
authors.initials: R
authors.lastname: Bonifay
authors.forename: Dany
authors.initials: D
authors.lastname: Anglicheau
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015415:Biomarkers; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology; D005355:Fibrosis; D006084:Graft Rejection / Q000276:immunology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D007668:Kidney / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D016030:Kidney Transplantation; D051379:Mice; D035683:MicroRNAs / Q000502:physiology* / Q000627:therapeutic use; D008954:Models, Biological; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability / Q000502:physiology; D043244:Ribonuclease III / Q000502:physiology
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D043244:Ribonuclease III