title: Adverse events associated with laparoscopy vs laparotomy in the treatment of endometrial cancer.
abstract: OBJECTIVE
  The objective of the study was to compare adverse event rates between laparoscopic vs open surgery for endometrial cancer.
  
  
  METHODS
  This was a retrospective cohort study comparing 107 women who underwent laparoscopy with 269 age- and body mass index-matched women who underwent laparotomy for treatment of endometrial cancer.
  
  
  RESULTS
  Adverse event rates were similar between cohorts (37% laparoscopy vs 43% laparotomy, P=.248). Laparotomies had higher rates of cellulitis (16% vs 7%, P=.018) and open wound infection (9% vs 2%, P=.02), whereas laparoscopy had higher rates of sensory peripheral nerve deficit (5% vs 0%, P=.008) and lymphedema (7% vs 1%, P=.003). Laparoscopy was associated with longer mean operating room times but with shorter hospital stays and lower mean blood loss.
  
  
  CONCLUSIONS
  Laparoscopy was associated with decreased rates of surgical site infections but had an increased risk of peripheral sensory nerve deficits and lymphedema when compared with laparotomy.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA.
authors.forename: Jason C
authors.initials: JC
authors.lastname: Barnett
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Havrilesky
authors.forename: Amy E
authors.initials: AE
authors.lastname: Bondurant
authors.forename: Nicole D
authors.initials: ND
authors.lastname: Fleming
authors.forename: Paula S
authors.initials: PS
authors.lastname: Lee
authors.forename: Angeles Alvarez
authors.initials: AA
authors.lastname: Secord
authors.forename: Andrew
authors.initials: A
authors.lastname: Berchuck
authors.forename: Fidel A
authors.initials: FA
authors.lastname: Valea
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects / Q000379:methods*; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods; D007813:Laparotomy / Q000009:adverse effects* / Q000379:methods; D007902:Length of Stay / Q000639:trends; D008197:Lymph Node Excision / Q000379:methods / Q000706:statistics & numerical data; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D010149:Postoperative Pain / Q000453:epidemiology / Q000503:physiopathology; D012189:Retrospective Studies; D018570:Risk Assessment; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome