title: Simple and efficient synthesis of racemic 2-(tert-butoxycarbon-ylamino)-2-methyl-3-(1H-1,2,4-triazol-1-yl)propanoic acid, a new derivative of β-(1,2,4-triazol-1-yl)alanine.
abstract: A simple synthetic approach to racemic N-tert-butyloxycarbonyl-2-methyl-3-(1H-1,2,4-triazol-1-yl)alanine (5) in four steps and 68% overall yield starting from oxazoline derivative 1 is reported. This synthesis involves the alkylation of 1H-1,2,4-triazole with an O-tosyloxazoline derivative, followed by an oxazoline ring-opening reaction and oxidation of the N-protected β‑aminoalcohol by potassium permanganate.
authors.affiliation: Laboratoire de Chimie Organique Fès, Faculté des Sciences Dhar El Mahraz, Université Sidi Mohamed Ben Abdellah, Morocco.
authors.forename: Younas
authors.initials: Y
authors.lastname: Aouine
authors.forename: Hassane
authors.initials: H
authors.lastname: Faraj
authors.forename: Anouar
authors.initials: A
authors.lastname: Alami
authors.forename: Abdelilah
authors.initials: A
authors.lastname: El-Hallaoui
authors.forename: Abdelrhani
authors.initials: A
authors.lastname: Elachqar
authors.forename: Abdelali
authors.initials: A
authors.lastname: Kerbal
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D014230:Triazoles