title: Association of sperm morphology and the sperm deformity index (SDI) with poly (ADP-ribose) polymerase (PARP) cleavage inhibition.
abstract: Apoptosis was induced in immature and mature sperm in the presence or absence of poly (ADP-ribose) polymerase (PARP) inhibitor. The association of cleaved (cPARP) with sperm morphology was examined using sperm deformity index (SDI) score. The SDI scores are associated with PARP cleavage as an early marker of apoptosis.
authors.affiliation: Liverpool Women's Hospital, University of Liverpool, United Kingdom.
authors.forename: Nabil
authors.initials: N
authors.lastname: Aziz
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Sharma
authors.forename: Reda
authors.initials: R
authors.lastname: Mahfouz
authors.forename: Rajesh
authors.initials: R
authors.lastname: Jha
authors.forename: Ashok
authors.initials: A
authors.lastname: Agarwal
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001549:Benzamides / Q000494:pharmacology; D053148:Caspase 3 / Q000378:metabolism; D048430:Cell Shape / Q000187:drug effects; D053938:DNA Fragmentation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D020287:In Situ Nick-End Labeling; D008297:Male; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D013077:Sperm Head / Q000201:enzymology / Q000473:pathology; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology*; D019311:Staurosporine / Q000494:pharmacology
chemical_list: D001549:Benzamides; D004791:Enzyme Inhibitors; D016877:Oxidants; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D047428:Protein Kinase Inhibitors; C025160:3-aminobenzamide; D006861:Hydrogen Peroxide; D011065:Poly(ADP-ribose) Polymerases; D011493:Protein Kinase C; C505407:CASP3 protein, human; D053148:Caspase 3; D019311:Staurosporine