title: Choline dendrimers as generic scaffolds for the non-covalent synthesis of multivalent protein assemblies.
abstract: A modular self-assembly strategy is presented that allows the non-covalent synthesis of multivalent protein dendrimers using the strong interaction between choline-functionalized dendrimers and the choline binding protein C-LytA. Choline dendrimers displaying fusion proteins of C-LytA and the collagen binding protein CNA35 represent attractive multivalent targeting ligands for collagen imaging.
authors.affiliation: Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Avda Universidad s/n, Elche 03202, Spain.
authors.forename: Víctor M
authors.initials: VM
authors.lastname: Hernández-Rocamora
authors.forename: Sanne W A
authors.initials: SW
authors.lastname: Reulen
authors.forename: Bas
authors.initials: B
authors.lastname: de Waal
authors.forename: E W
authors.initials: EW
authors.lastname: Meijer
authors.forename: Jesus M
authors.initials: JM
authors.lastname: Sanz
authors.forename: Maarten
authors.initials: M
authors.lastname: Merkx
mesh_terms: D000581:Amidohydrolases / Q000737:chemistry / Q000378:metabolism; D002794:Choline / Q000737:chemistry*; D003094:Collagen / Q000378:metabolism; D050091:Dendrimers / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D050091:Dendrimers; D011506:Proteins; D011993:Recombinant Fusion Proteins; D003094:Collagen; D000581:Amidohydrolases; C019665:amidase; D002794:Choline