title: Serial assessment of the coagulation status of dogs with immune-mediated haemolytic anaemia using thromboelastography.
abstract: This study investigated the coagulation status of dogs with immune-mediated haemolytic anaemia (IMHA) over time. Thirty animals with primary IMHA were blood sampled on three occasions over a 5 day period and assays performed included prothrombin time, activated partial thromboplastin time, D-dimer and fibrinogen concentration, antithrombin activity and recalcified unactivated thromboelastography (TEG). Based on TEG, dogs with IMHA were significantly hypercoagulable vs. controls (P<0.001) and over the 5 day period, 3/4 of the TEG parameters reflected increased clotting kinetics (P ≤ 0.02). The 30 day survival of these patients was 80% and, at hospital admission, the TEG maximum amplitude (MA) was significantly higher in survivors than non-survivors (P=0.015). Each unit increase in MA was associated with an increased odds of 30 day survival of 1.13 (95%; CI 1.02-1.25). Based on TEG, most dogs with IMHA were hypercoagulable on admission and their clotting kinetics increased with time. Relative hypocoagulability identified by TEG at initial assessment was found to be a negative prognostic indicator.
authors.affiliation: Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK. rob.goggs@bristol.ac.uk
authors.forename: R
authors.initials: R
authors.lastname: Goggs
authors.forename: B
authors.initials: B
authors.lastname: Wiinberg
authors.forename: M
authors.initials: M
authors.lastname: Kjelgaard-Hansen
authors.forename: D L
authors.initials: DL
authors.lastname: Chan
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000662:veterinary*; D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D008297:Male; D013916:Thrombelastography / Q000379:methods / Q000662:veterinary*