title: Systems biology model repository for macrophage pathway simulation.
abstract: CONCLUSIONS
  The Macrophage Pathway Knowledgebase (MACPAK) is a computational system that allows biomedical researchers to query and study the dynamic behaviors of macrophage molecular pathways. It integrates the knowledge of 230 reviews that were carefully checked by specialists for their accuracy and then converted to 230 dynamic mathematical pathway models. MACPAK comprises a total of 24 009 entities and 12 774 processes and is described in the Cell System Markup Language (CSML), an XML format that runs on the Cell Illustrator platform and can be visualized with a customized Cytoscape for further analysis.
  
  
  BACKGROUND
  MACPAK can be accessed via an interactive web site at http://macpak.csml.org. The CSML pathway models are available under the Creative Commons license.
authors.affiliation: Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. masao@hgc.jp
authors.forename: Masao
authors.initials: M
authors.lastname: Nagasaki
authors.forename: Ayumu
authors.initials: A
authors.lastname: Saito
authors.forename: André
authors.initials: A
authors.lastname: Fujita
authors.forename: Georg
authors.initials: G
authors.lastname: Tremmel
authors.forename: Kazuko
authors.initials: K
authors.lastname: Ueno
authors.forename: Emi
authors.initials: E
authors.lastname: Ikeda
authors.forename: Euna
authors.initials: E
authors.lastname: Jeong
authors.forename: Satoru
authors.initials: S
authors.lastname: Miyano
mesh_terms: D003198:Computer Simulation; D051188:Knowledge Bases; D008070:Lipopolysaccharides / Q000502:physiology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D018448:Models, Immunological; D015398:Signal Transduction; D012984:Software; D049490:Systems Biology
chemical_list: D008070:Lipopolysaccharides