title: [Thyroid hormone and cerebellum development: direct and indirect effects?].
abstract: Thyroid hormone (T₃) exerts an important influence on neurodevelopment, which can be analysed by using the postnatal development of rodent cerebellum as a model. T₃ acts on all types of neuronal and glial cells, which express at least the TRα1 nuclear receptor, and, for some of them, the TRβ1 isoform. However, as T₃ also activates the secretion of neurotrophins, it can also affect cellular differentiation in an indirect manner. Ongoing experiments, based on mouse genetics and genome wide analysis of gene expression, provide a promising way to study the basic mechanisms of neurodevelopment. This review describes new mouse genetics models and recent advance in this field.
authors.affiliation: Pôle neurodéveloppement, laboratoire de biologie moléculaire et cellulaire, institut de génomique fonctionnelle de Lyon, école normale supérieure de Lyon, UMR CNRS 5242, 46, allée d'Italie, 69364 Lyon cedex 07, France.
authors.forename: F
authors.initials: F
authors.lastname: Chatonnet
authors.forename: T
authors.initials: T
authors.lastname: Fauquier
authors.forename: F
authors.initials: F
authors.lastname: Picou
authors.forename: R
authors.initials: R
authors.lastname: Guyot
authors.forename: F
authors.initials: F
authors.lastname: Flamant
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000254:growth & development*; D020869:Gene Expression Profiling; D023281:Genomics; D051379:Mice; D023421:Models, Animal; D009414:Nerve Growth Factors / Q000378:metabolism; D055495:Neurogenesis; D037021:Thyroid Hormone Receptors alpha / Q000235:genetics*; D014284:Triiodothyronine / Q000235:genetics*
chemical_list: D009414:Nerve Growth Factors; D037021:Thyroid Hormone Receptors alpha; D014284:Triiodothyronine