title: Further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010).
abstract: The activity of three anthelmintics (fenbendazole-FBZ; oxibendazole-OBZ; and pyrantel pamoate-PRT) was ascertained against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010) in field tests. A total of 316 foals were treated, and 168 (53.2%) were passing ascarid eggs on the day of treatment. Evaluation of drug efficacy was determined qualitatively by comparing the number of foals passing ascarid eggs in their feces before and after treatment. The main purpose was to obtain data on current activity of these compounds against ascarids. Additionally, the objective was to compare these findings with those from earlier data on the efficacy of these three compounds on nematodes in foals in this geographical area. Efficacies (average) for the foals ranged for FBZ (10 mg/kg) from 50% to 100% (80%), for OBZ (10 mg/kg) from 75% to 100% (97%), and for PRT at 1× (6.6 mg base/kg) from 0% to 71% (2%) and at 2× (13.2 mg base/kg) 0% to 0% (0%). Although the efficacy varied among the drugs, combined data for all farms indicated a significant reduction of ascarid infections for FBZ (p < 0.0001) and OBZ (p < 0.0001) but not for PRT (p = 0.0953).
authors.affiliation: Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546-0099, USA. elyons1@uky.edu
authors.forename: Eugene T
authors.initials: ET
authors.lastname: Lyons
authors.forename: Sharon C
authors.initials: SC
authors.lastname: Tolliver
authors.forename: Tetiana A
authors.initials: TA
authors.lastname: Kuzmina
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Collins
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use; D017191:Ascaridida Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology / Q000662:veterinary; D001199:Ascaridoidea / Q000187:drug effects* / Q000502:physiology; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D005243:Feces; D005273:Fenbendazole / Q000494:pharmacology* / Q000627:therapeutic use; D006734:Horse Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D006736:Horses; D007629:Kentucky; D010270:Parasite Egg Count / Q000662:veterinary; D011716:Pyrantel Pamoate / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; C011321:oxibendazole; D005273:Fenbendazole; D011716:Pyrantel Pamoate