title: [Effect of GDF15 on iron overloading and erythropoiesis].
abstract: Ineffective erythropoiesis is recognized as the principal reason of non-transfusional iron overload. In the process of expanded erythropoiesis, the apoptosis of erythroblasts induces the up-regulation of GDF15. GDF15 suppresses hepcidin production by the hepatocytes. Subsequently, low hepcidin levels increase iron absorption from the intestine resulting in iron overload. Physiological dose of GDF15 can promote the growth and differentiation of erythroid progenitors, but the high dose of GDF15 can suppress the secretion of hepcidin. The regulation of GDF15 may also be related to iron levels, epigenetic regulation and hypoxia. In this article the GDF15 and its expression and distribution, roles of GDF15 in erythropoiesis and iron overload, as well as the regulation factors of GDF15 are reviewed.
authors.affiliation: Department of Hematology, Shanghai Jiaotong University, Shanghai 200233, China.
authors.forename: You-Shan
authors.initials: YS
authors.lastname: Zhao
authors.forename: Chun-Kang
authors.initials: CK
authors.lastname: Chang
mesh_terms: D004920:Erythropoiesis; D055436:Growth Differentiation Factor 15 / Q000378:metabolism*; D006801:Humans; D019190:Iron Overload
chemical_list: D055436:Growth Differentiation Factor 15