title: A concise approach for the total synthesis of pseudolaric acid A.
abstract: A new strategy for the stereoselective total synthesis of natural product pseudolaric acid A (1) was accomplished in 16 steps from commercially available starting material, featuring a samarium diiodide (SmI(2))-mediated intramolecular alkene-ketyl radical cyclization and a ring-closing metathesis (RCM) reaction to stereoselectively cast the unusual trans-fused [5-7]-bicyclic core of pseudolaric acid A (1).
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Chuang-chuang
authors.initials: CC
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D007454:Iodides / Q000737:chemistry; D015394:Molecular Structure; D028201:Pinaceae / Q000737:chemistry; D012493:Samarium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D004224:Diterpenes; D007454:Iodides; D012493:Samarium; C058390:pseudolaric acid A; C409809:samarium diiodide