title: Birth of a healthy infant after intracytoplasmic sperm injection using pentoxifylline-activated sperm from a patient with Kartagener's syndrome.
abstract: OBJECTIVE
  To describe the delivery of a healthy female infant after intracytoplasmic sperm injection (ICSI) using pentoxifylline-activated sperm from a patient with Kartagener's syndrome.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Private assisted reproductive technology clinic in Japan.
  
  
  METHODS
  A couple with male factor infertility due to Kartagener's syndrome.
  
  
  METHODS
  Intracytoplasmic sperm injection using ejaculated sperm activated by pentoxifylline.
  
  
  METHODS
  Semen characteristics, sperm ultrastructure, fertilization, pregnancy, and birth after ICSI.
  
  
  RESULTS
  The fertilization rate was 7 of 12 (58.3%), and the blastocyst formation rate was 4 of 7 (57.1%); all blastocysts were vitrified. After a single blastcyst transfer, a pregnancy ensued and progressed to term; a healthy female infant was delivered.
  
  
  CONCLUSIONS
  With ejaculated sperm, which was activated by pentoxifylline, successful fertilization was accomplished by ICSI; thus, fertilization, vitrification, pregnancy, and delivery are attainable with sperm obtained from men with Kartagener's syndrome.
authors.affiliation: Kyono ART Clinic, Sendai, Japan.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Hattori
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nakajo
authors.forename: Chizuru
authors.initials: C
authors.lastname: Ito
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Toyama
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Toshimori
authors.forename: Koichi
authors.initials: K
authors.lastname: Kyono
mesh_terms: D000328:Adult; D004542:Ejaculation; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007619:Kartagener Syndrome / Q000150:complications* / Q000503:physiopathology; D050498:Live Birth; D008297:Male; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D010431:Pentoxifylline / Q000627:therapeutic use*; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D010431:Pentoxifylline