title: Polymeric coating of surface modified nitinol stent with POSS-nanocomposite polymer.
abstract: Stent angioplasty is a successful treatment for arterial occlusion, particularly in coronary artery disease. The clinical communities were enthusiastic about the use of drug-eluting stents; however, these stents have a tendency to be a contributory factor towards late stage thrombosis, leading to mortality in a significant number of patients per year. This work presents an innovative approach in self-expanding coronary stents preparation. We developed a new nanocomposite polymer based on polyhedral oligomeric silsesquioxanes (POSS) and poly(carbonate-urea)urethane (PCU), which is an antithrombogenic and a non-biodegradable polymer with in situ endothelialization properties. The aim of this work is to coat a NiTi stent alloy with POSS-PCU. In prolonged applications in the human body, the corrosion of the NiTi alloy can result in the release of deleterious ions which leads to unwanted biological reactions. Coating the nitinol (NiTi) surface with POSS-PCU can enhance surface resistance and improve biocompatibility. Electrohydrodynamic spraying was used as the polymer deposition process and thus a few experiments were carried out to compare this process with casting. Prior to deposition the NiTi has been surface modified. The peel strength of the deposit was studied before and after degradation of the coating. It is shown that the surface modification enhances the peel strength by 300%. It is also indicated how the adhesion strength of the POSS-PCU coating changes post-exposure to physiological solutions comprised of hydrolytic, oxidative, peroxidative and biological media. This part of the study shows that the modified NiTi presents far greater resistance to decay in peel strength compared to the non-modified NiTi.
authors.affiliation: University College London, Centre for Nanotechnology and Regenerative Medicine, London, UK.
authors.forename: Raheleh
authors.initials: R
authors.lastname: Bakhshi
authors.forename: Arnold
authors.initials: A
authors.lastname: Darbyshire
authors.forename: James Eaton
authors.initials: JE
authors.lastname: Evans
authors.forename: Zhong
authors.initials: Z
authors.lastname: You
authors.forename: Jian
authors.initials: J
authors.lastname: Lu
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Seifalian
mesh_terms: D000497:Alloys / Q000737:chemistry; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry; D054855:Drug-Eluting Stents; D006801:Humans; D053761:Nanocomposites / Q000009:adverse effects / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry; D017646:Organosilicon Compounds / Q000737:chemistry; D010084:Oxidation-Reduction / Q000187:drug effects; D011108:Polymers / Q000009:adverse effects / Q000737:chemistry*; D012709:Serum Albumin / Q000187:drug effects; D000075462:Serum Albumin, Human; D012712:Serum Globulins / Q000187:drug effects; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D017646:Organosilicon Compounds; D011108:Polymers; D012709:Serum Albumin; D012712:Serum Globulins; C040654:titanium nickelide; C008930:plasma protein fraction; D009532:Nickel; D014025:Titanium; D000075462:Serum Albumin, Human