title: Wernicke's encephalopathy induced by total parental nutrition.
abstract: Wernicke's encephalopathy is an acute neurological syndrome due to thiamine deficiency, which is characterized by a typical triad of mental status changes, oculomotor dysfunction and ataxia. Despite the fact that Wernicke's encephalopathy, in developed countries, is frequently associated with chronic alcoholism, there have been a number of published cases associating this encephalopathy with parenteral feeding without vitamin supplementation. Diagnosis is primarily a clinical one, and can be supported by laboratory tests and imaging studies; treatment should start as soon as possible, for the morbidity and mortality (almost 20%) associated with this syndrome is high. Thiamine supplementation, along with other vitamins, is recommended for patients in risk of developing this syndrome.
authors.affiliation: Servicio de Medicina Interna, Hospital Infanta Cristina, Badajoz, España.
authors.forename: J T
authors.initials: JT
authors.lastname: Sequeira Lopes da Silva
authors.forename: R
authors.initials: R
authors.lastname: Almaraz Velarde
authors.forename: F
authors.initials: F
authors.lastname: Olgado Ferrero
authors.forename: M
authors.initials: M
authors.lastname: Robles Marcos
authors.forename: D
authors.initials: D
authors.lastname: Pérez Civantos
authors.forename: J M
authors.initials: JM
authors.lastname: Ramírez Moreno
authors.forename: L M
authors.initials: LM
authors.lastname: Luengo Pérez
mesh_terms: D000328:Adult; D003422:Critical Care; D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D010438:Peptic Ulcer Hemorrhage / Q000150:complications / Q000628:therapy; D012771:Shock, Hemorrhagic / Q000209:etiology / Q000628:therapy; D013788:Thalamus / Q000473:pathology; D013831:Thiamine / Q000008:administration & dosage / Q000627:therapeutic use; D013832:Thiamine Deficiency / Q000150:complications / Q000175:diagnosis; D014057:Tomography, X-Ray Computed; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use; D014899:Wernicke Encephalopathy / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
chemical_list: D014815:Vitamins; D013831:Thiamine