title: A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis.
abstract: A new iridoid, named methylscutelloside (1) together with 19 known compounds belonging to the iridoids (2-4), monoterpenoids (5), flavonoids (6-8), triterpenoids (9-14), and phenylethanoids (15-20) were isolated from the flowers of Buddleja officinalis. Their chemical structures were elucidated on the basis of physicochemical properties, and by spectroscopic methods including 1D, 2D NMR, and MS. All isolated compounds were tested in vitro for their effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Tran Hong
authors.initials: TH
authors.lastname: Quang
authors.forename: Nguyen Thi Thanh
authors.initials: NT
authors.lastname: Ngan
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: Tung
authors.forename: Yohan
authors.initials: Y
authors.lastname: Kim
authors.forename: Jung-Jin
authors.initials: JJ
authors.lastname: Lee
authors.forename: Chang-Seon
authors.initials: CS
authors.lastname: Myung
authors.forename: Nguyen Manh
authors.initials: NM
authors.lastname: Cuong
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects*; D032861:Buddleja / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D035264:Flowers / Q000737:chemistry*; D039823:Iridoids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
chemical_list: D039823:Iridoids; D010936:Plant Extracts