title: [Hypertension in the aged: some peculiarities of pathogenesis].
abstract: Complex investigation of the structural myocardial and common carotid artery reconstruction was held to reveal some features of hypertension in the aged. The state of lipid metabolism, parameters of the oxidant system and inflammation markers were determined in healthy people (n = 30) and patients with hypertension (n = 132) of 60-74 years old. The results were discussed according to the view that adipose tissue mass elevation may be a reason for the age-associated process of the myocardial and blood vessel reconstruction from adaptive into the pathologic one. The myocardial wall is thickened because of the cardiomyocites proliferation and carotid arterial wall because of inflammation and lipid peroxidation activation. Hydrogen peroxide and nitric oxide may be regarded as markers of the oxidative stress on the background of age dependent changes of homeostasis.
authors.forename: N K
authors.initials: NK
authors.lastname: Gorshunova
authors.forename: E V
authors.initials: EV
authors.lastname: Tereshina
authors.forename: D N
authors.initials: DN
authors.lastname: Ukraintseva
mesh_terms: D050154:Adiposity; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D007249:Inflammation / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D012307:Risk Factors; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide; D006861:Hydrogen Peroxide