title: Association study between plasma GDNF and cognitive function in late-onset depression.
abstract: OBJECTIVE
  Improving evidence suggest that neurotrophic growth factor systems might be involved in the pathophysiology of major depressive disorder (MDD). The glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor-β-family, which plays a role in the development and function of hippocampal cells. This study was aimed to test whether GDNF in plasma was abnormal in late-onset depression (LOD), and whether it was associated with the cognitive impairment of LOD.
  
  
  METHODS
  The plasma GDNF levels in LOD patients (n=27) before antidepressant treatment and normal control subjects (n=28) were measured with the ELISA method. All subjects were assessed by neuropsychological tests and Hamilton Depression Rating Scale (HDRS).
  
  
  RESULTS
  The performance of neuropsychological tests of the LOD group except TMT-B was significantly poorer than those of the control group. The plasma GDNF levels in LOD patients were significantly increased compared to control subjects (P<0.05). Furthermore, the increase of plasma GDNF level was significantly positively correlated with Digit Span Test backward score in LOD patients, and negatively associated with TMT-B performance.
  
  
  CONCLUSIONS
  The findings suggest that LOD patients in acute phase have extensive impairments of cognitive function, and higher plasma GDNF might be involved in the pathogenesis of LOD, which may be associated with the cognitive dysfunction in LOD.
authors.affiliation: Department of Psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, PR China.
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Wang
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Hou
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
authors.forename: Gang
authors.initials: G
authors.lastname: Hou
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Hailin
authors.initials: H
authors.lastname: Li
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D003072:Cognition Disorders / Q000150:complications*; D003863:Depression; D003866:Depressive Disorder / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
chemical_list: D000928:Antidepressive Agents; C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor