title: [Prediction of maternofetal infection in preterm premature rupture of membranes: serum maternal markers].
abstract: Premature rupture of membranes is a common situation in obstetrics that links the amniotic cavity and the bacterial cervicovaginal flora. The main risk in case of preterm premature rupture of membranes is the occurrence of an amniochorial infection, which increases neonatal morbidity and mortality. One main purpose in cases of preterm premature rupture of membranes is to identify infection early to adapt the clinical care. Among the marker used in practice, CRP has a sensitivity between 56% and 86% and specificity between 55% and 82% for predicting clinical chorioamnionitis. These values are respectively 21% to 56% and 76% to 95% for the prediction of early neonatal infection. The white blood cell count, also used in routine, has a poor predictive value of clinical chorioamnionitis although a high specificity when the threshold is of 16 giga/l. Among the pro-inflammatory cytokines, interleukin-6 has been the most studied. Its predictive value for chorioamnionitis or neonatal infection is higher but its clinical usefulness is limited by the various threshold used in the studies and the lack of routine measure. Procalcitonin appears to have low predictive values for detecting amniochorial infection but has finally been little studied. Ways to improve prediction of infection in cases of premature rupture of membranes are either looking for new markers or the analysis of local markers (vaginal secretions and amniotic fluid).
authors.affiliation: Inserm 953, Unité de Recherche Épidémiologique en Santé Périnatale et en Santé des Femmes et des Enfants, 82 avenue Denfert-Rochereau, 75014 Paris, France. thomas.popof@wanadoo.fr
authors.forename: T
authors.initials: T
authors.lastname: Popowski
authors.forename: F
authors.initials: F
authors.lastname: Goffinet
authors.forename: F
authors.initials: F
authors.lastname: Batteux
authors.forename: F
authors.initials: F
authors.lastname: Maillard
authors.forename: G
authors.initials: G
authors.lastname: Kayem
mesh_terms: D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D002821:Chorioamnionitis / Q000175:diagnosis / Q000382:microbiology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology*; D047928:Premature Birth / Q000097:blood / Q000382:microbiology*; D011498:Protein Precursors / Q000097:blood; D012680:Sensitivity and Specificity; D014621:Vagina / Q000382:microbiology
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D015850:Interleukin-6; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide