title: Synthesis of the stereogenic triad of the halicyclamine A core.
abstract: We describe herein our progress toward the synthesis of halicyclamine A, which possesses very interesting biological activities and has never been synthesized. For this purpose, we proposed a stereoselective Diels-Alder reaction as a key step for the establishment of the stereogenic triad of the bis(piperidinyl) core of this molecule. A series of NMR studies was then conducted to establish the correct stereochemical assignment subsequent to the Diels-Alder reaction.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323.
authors.forename: Gary A
authors.initials: GA
authors.lastname: Molander
authors.forename: Frédéric
authors.initials: F
authors.lastname: Cadoret