title: Regio- and stereoselective synthesis of 2-amino-1,3-diene derivatives by ruthenium-catalyzed coupling of ynamides and ethylene.
abstract: A ruthenium-catalyzed hydrovinylation-type cross-coupling of ynamides and ethylene proceeds via ruthenacyclopentene to give 2-aminobuta-1,3-diene derivatives in a highly regioselective manner. It was also demonstrated that 2-aminobuta-1,3-diene derivatives reacted with various dienophiles or singlet oxygen to give a cyclic enamide derivative.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. nozomi-s@pharm.hokudai.ac.jp
authors.forename: Nozomi
authors.initials: N
authors.lastname: Saito
authors.forename: Keiichi
authors.initials: K
authors.lastname: Saito
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000466:Alkadienes / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D005030:Ethylenes / Q000737:chemistry*; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000466:Alkadienes; D000480:Alkynes; D000577:Amides; D005030:Ethylenes; D012428:Ruthenium; C036216:ethylene