title: Investigation of serum tumor markers in the diagnosis of gastric cancer.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the value of the tumor marker biochip C12 system in gastric cancer.
  
  
  METHODS
  A retrospective study of 183 patients with gastric cancer undergoing resection of gastric carcinoma was performed. Correlations between tumor markers and clinicopathologic features were evaluated univariately and multivariately. The most beneficial combination of key tumor markers in gastric cancer diagnosis was selected using chi-squared test.
  
  
  RESULTS
  The total positive rate of tumor markers for patients with gastric cancer was 42.6%. Multivariate logistic regression analysis revealed that the serum result of CA19-9 and CA125 were correlated with N stage, the serum result of CA242 was correlated with T stage and N stage, while the serum result of CEA was correlated with clinical stage and tumor histological differentiation (p < 0.05). Combinations of three tumor markers with high positive rates were CA242 + CEA + CA19-9 and CA242 + CEA + CA125, positive rates of which were 35.0% and 34.4% respectively with no statistical significance compared with twelve tumor markers combination (chi-squared test, p > 0.05).
  
  
  CONCLUSIONS
  The tumor marker biochip system has important diagnostic value in gastric cancer. CA19-9, CA242, CEA and CA125 were four key markers in tumor diagnosis.
authors.affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Fan
authors.forename: Bin
authors.initials: B
authors.lastname: Xiong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C074601:CA 242 antigen; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen