title: Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
authors.affiliation: Pharmaceuticals Division, F. Hoffmann-La Roche Ltd. , CH- 4070 Basel, Switzerland. simona_m.ceccarelli@roche.com
authors.forename: Simona M
authors.initials: SM
authors.lastname: Ceccarelli
authors.forename: Odile
authors.initials: O
authors.lastname: Chomienne
authors.forename: Marcel
authors.initials: M
authors.lastname: Gubler
authors.forename: Arduino
authors.initials: A
authors.lastname: Arduini
mesh_terms: D000818:Animals; D002331:Carnitine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D002334:Carnitine O-Palmitoyltransferase / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000378:metabolism*; D020134:Catalytic Domain; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D020536:Enzyme Activators / Q000494:pharmacology / Q000627:therapeutic use; D005027:Ethylene Oxide / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000378:metabolism; D009928:Organ Specificity; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid; D013237:Stereoisomerism
chemical_list: D020536:Enzyme Activators; D007527:Isoenzymes; D002334:Carnitine O-Palmitoyltransferase; D005027:Ethylene Oxide; D002331:Carnitine