title: Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3.
abstract: Various cytokines are involved in the regulation of the immune system and inflammation. Dysregulation of cytokine signaling can cause a variety of diseases, including allergy, autoimmune diseases, inflammation, and cancer. Most cytokines use the so-called janus kinase/signal transducer and activator of transcription pathway, and this pathway is negatively regulated by suppressors of cytokine signaling (SOCS) proteins. SOCS proteins bind to janus kinase and to certain cytokine receptors and signaling molecules, thereby suppressing further signaling events. Studies have shown that SOCS proteins are key physiological regulators of inflammation. Recent studies have also demonstrated that SOCS1 and SOCS3 are important regulators of adaptive immunity.
authors.affiliation: Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Taiga
authors.initials: T
authors.lastname: Tamiya
authors.forename: Ikko
authors.initials: I
authors.lastname: Kashiwagi
authors.forename: Reiko
authors.initials: R
authors.lastname: Takahashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Yasukawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshimura
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000276:immunology; D018836:Inflammation Mediators / Q000378:metabolism*; D053612:Janus Kinases / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
chemical_list: D018836:Inflammation Mediators; D050791:STAT Transcription Factors; D050826:Suppressor of Cytokine Signaling Proteins; D053612:Janus Kinases