title: Rheumatoid arthritis and periodontitis; a possible link via citrullination.
abstract: Rheumatoid Arthritis (RA) and chronic and aggressive periodontitis are chronic inflammatory disorders characterized by deregulation of the host inflammatory response. Increased secretion of pro-inflammatory mediators results in soft and hard tissue destruction of the synovium and periodontium respectively. Both diseases share risk factors and have pathological pathways in common, resulting in loss of function and disability as a final clinical outcome. This article discusses possible interactions, particularly related to the periodontal pathogen Porphyromonas gingivalis, which could explain the observed association between these two prevalent diseases.
authors.affiliation: Center for Dentistry and Oral Hygiene, Department of Periodontology, University Medical Center Groningen, University of Groningen, The Netherlands. m.j.de.smit@med.umcg.nl
authors.forename: M J
authors.initials: MJ
authors.lastname: de Smit
authors.forename: E
authors.initials: E
authors.lastname: Brouwer
authors.forename: A
authors.initials: A
authors.lastname: Vissink
authors.forename: A J
authors.initials: AJ
authors.lastname: van Winkelhoff
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology* / Q000473:pathology; D002956:Citrulline / Q000378:metabolism*; D006801:Humans; D010518:Periodontitis / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology* / Q000473:pathology; D016966:Porphyromonas gingivalis / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D002956:Citrulline