title: H2O2, signal, substrate, mutagen and chemorepellent from physiology to biochemistry and disease.
abstract: The history of the study by our group of the generation, the role and the effects of H2O2 in the thyroid, is summarized. The relations with thyroid diseases are discussed: myxedematous cretinism, thyroiditis, thyroid cancer, congenital hypothyroiddism, are discussed. A new role of H2O2 in the chemorepulsion of bacteria is proposed.
authors.affiliation: IRIBHM and Laboratory of Microbiology, School of Medicine, University of Brussels.
authors.forename: J E
authors.initials: JE
authors.lastname: Dumont
authors.forename: X
authors.initials: X
authors.lastname: De Deken
authors.forename: F
authors.initials: F
authors.lastname: Miot
authors.forename: V
authors.initials: V
authors.lastname: Corvilain
authors.forename: B
authors.initials: B
authors.lastname: Contempré
authors.forename: R
authors.initials: R
authors.lastname: Goyens
authors.forename: C
authors.initials: C
authors.lastname: Massart
authors.forename: J
authors.initials: J
authors.lastname: Van Sande
authors.forename: A
authors.initials: A
authors.lastname: Allaoui
authors.forename: A
authors.initials: A
authors.lastname: Botteaux
mesh_terms: D000074623:Dual Oxidases; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D019255:NADPH Oxidases / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000378:metabolism; D016606:Thyroid Nodule / Q000378:metabolism
chemical_list: D006861:Hydrogen Peroxide; D000074623:Dual Oxidases; D019255:NADPH Oxidases; C431513:DUOX1 protein, human