title: Diffusion tensor magnetic resonance imaging tractography in progressive supranuclear palsy.
abstract: BACKGROUND
  Diffusion tensor magnetic resonance imaging tractography allows quantification of in vivo white matter tract damage.
  
  
  METHODS
  Using tractography, diffusion tensor magnetic resonance imaging metrics were obtained from the superior and middle cerebellar peduncles and major cerebral white matter tracts in 5 patients with progressive supranuclear palsy and 13 controls.
  
  
  RESULTS
  Patients showed severe intrinsic damage to the superior cerebellar peduncle, corpus callosum, and cingulum bilaterally. Only decreased axial diffusivity was found in the left middle cerebellar peduncle.
  
  
  CONCLUSIONS
  Diffusion tensor magnetic resonance imaging tractography holds promise for providing accurate in vivo cartography of progressive supranuclear palsy tissue damage.
authors.affiliation: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Canu
authors.forename: Federica
authors.initials: F
authors.lastname: Agosta
authors.forename: Francesca
authors.initials: F
authors.lastname: Baglio
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Galantucci
authors.forename: Raffaello
authors.initials: R
authors.lastname: Nemni
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D018709:Statistics, Nonparametric; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis*