title: 64-multidetector computed tomographic angiography of the canine coronary arteries.
abstract: Canine coronary artery angiography (CTA) was performed in four anesthetized healthy dogs using 64-multidetector computed tomography. Esmolol, a β-1 adrenergic receptor antagonist, and sodium nitroprusside, an arteriolar and venous dilator, were administered to enhance visualization of the coronary arteries by reducing heart rate and creating vasodilation. The left main coronary artery with its three main branches and the right coronary artery were visualized and subdivided in 13 segments for evaluation. Optimal reconstruction interval, expressed as percentage of the R-to-R interval, was determined at 5% in 2.9%, 35% in 1%, 75% in 21.2%, 85% in 43.3%, and 95% in 31.7% of the segments. Overall image quality was good in 41.3% of the segments and excellent in 14.4%. There was blur in 98.1%, motion in 17.3%, and stair step in 6.7% of the evaluated segments, but these artifacts did not interfere with anatomic depiction of the arteries. Cross-sectional anatomy of the coronary arteries as evaluated from the coronary CTA agreed well with gross anatomic evaluation and published information. The use of esmolol did not lead to the target heart rate of 60-65 beats/min. Nitroprusside had no significant effect on visualized length or diameter of the coronary artery branches. Coronary CTA is useful for the anatomic depiction of coronary artery branches in the dog.
authors.affiliation: Department of Surgical Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA. drees@svm.vetmed.wisc.edu
authors.forename: Randi
authors.initials: R
authors.lastname: Drees
authors.forename: Alex
authors.initials: A
authors.lastname: Frydrychowicz
authors.forename: Scott B
authors.initials: SB
authors.lastname: Reeder
authors.forename: Marie E
authors.initials: ME
authors.lastname: Pinkerton
authors.forename: Rebecca
authors.initials: R
authors.lastname: Johnson
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000008:administration & dosage; D000818:Animals; D003287:Contrast Media; D017023:Coronary Angiography / Q000662:veterinary*; D003331:Coronary Vessels / Q000187:drug effects; D004285:Dogs; D009599:Nitroprusside / Q000008:administration & dosage; D011412:Propanolamines / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed / Q000662:veterinary*; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D003287:Contrast Media; D011412:Propanolamines; D014665:Vasodilator Agents; D009599:Nitroprusside; C036604:esmolol