title: TET2 mutations in secondary acute myeloid leukemias: a French retrospective study.
abstract: Ten-eleven translocation 2 (TET2) mutations have been involved in myeloid malignancies. This retrospective study aims at evaluating the frequency and impact of TET2 mutations in 247 secondary acute myeloid leukemia cases referred to as myelodysplasia-related changes (n=201) or therapy-related (n=46) leukemias. Mutation of at least one copy of the TET2 gene was detected in 49 of 247 (19.8%) patients who presented with older age, higher hemoglobin level, higher neutrophil and monocyte counts, and lower platelet count. TET2 mutations were significantly less frequent in therapy-related (8.7%) than myelodysplasia-related changes (22.3%; P=0.035) leukemias and strongly associated with normal karyotype (P<0.001). TET2 mutations did not significantly associate with NPM1, FLT3-ITD or FLT3-D835, WT1, or N- or K-RAS mutations. Complete remission was achieved in 57% of evaluable patients who had received intensive chemotherapy. In this group, TET2 mutations did not influence the complete remission rate or overall survival.
authors.affiliation: Service d'Hématologie Biologique, GH Broca-Cochin-Hôtel-Dieu, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Kosmider
authors.forename: Eric
authors.initials: E
authors.lastname: Delabesse
authors.forename: Véronique Mansat
authors.initials: VM
authors.lastname: de Mas
authors.forename: Pascale
authors.initials: P
authors.lastname: Cornillet-Lefebvre
authors.forename: Odile
authors.initials: O
authors.lastname: Blanchet
authors.forename: Alain
authors.initials: A
authors.lastname: Delmer
authors.forename: Christian
authors.initials: C
authors.lastname: Recher
authors.forename: Sophie
authors.initials: S
authors.lastname: Raynaud
authors.forename: Didier
authors.initials: D
authors.lastname: Bouscary
authors.forename: Franck
authors.initials: F
authors.lastname: Viguié
authors.forename: Catherine
authors.initials: C
authors.lastname: Lacombe
authors.forename: Olivier A
authors.initials: OA
authors.lastname: Bernard
authors.forename: Norbert
authors.initials: N
authors.lastname: Ifrah
authors.forename: François
authors.initials: F
authors.lastname: Dreyfus
authors.forename: Michaëla
authors.initials: M
authors.lastname: Fontenay
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004268:DNA-Binding Proteins / Q000235:genetics*; D049308:Dioxygenases; D005260:Female; D005602:France; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D016609:Neoplasms, Second Primary / Q000235:genetics* / Q000401:mortality; D000090243:Nucleophosmin; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012189:Retrospective Studies; D016019:Survival Analysis; D025721:WT1 Proteins / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; C000716967:NPM1 protein, human; D011518:Proto-Oncogene Proteins; D025721:WT1 Proteins; D000090243:Nucleophosmin; D049308:Dioxygenases; C541081:TET2 protein, human