title: Single nucleotide polymorphisms of integrin alpha-2 and beta-3 genes are not associated with relapse-free and overall survival in colorectal cancer patients.
abstract: BACKGROUND
  Integrins influence tumourigenesis, tumor progression and development of metastases. The impact of polymorphisms in integrin genes on relapse-free survival (RFS) and overall survival (OS) for 433 Caucasian patients with colorectal cancer was analysed in this retrospective study.
  
  
  METHODS
  A Cox regression model including integrin genotype, age, grading, tumour size, number of lymph nodes examined, number of metastatic lymph nodes, stage and application of fluorouracil-based adjuvant chemotherapy was used to estimate their effect.
  
  
  RESULTS
  After a median follow-up of 41 months for RFS and 55 months for OS, no significant correlation between the ITGA2 1648A allele (RFS p=0.618, OS p=0.604), the ITGA2 807T allele (RFS p=0.603, OS p=0.807) and the ITGB3 176C allele (RFS p=0.719, OS p=0.261) and survival was detectable.
  
  
  CONCLUSIONS
  The investigated integrin polymorphisms are not associated with RFS or OS in colorectal cancer patients.
authors.affiliation: Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. guenter.hofmann@medunigraz.at
authors.forename: Günter
authors.initials: G
authors.lastname: Hofmann
authors.forename: Uwe
authors.initials: U
authors.lastname: Langsenlehner
authors.forename: Tanja
authors.initials: T
authors.lastname: Langsenlehner
authors.forename: Matthias
authors.initials: M
authors.lastname: Glehr
authors.forename: Armin
authors.initials: A
authors.lastname: Gerger
authors.forename: Gudrun
authors.initials: G
authors.lastname: Absenger
authors.forename: Joanna
authors.initials: J
authors.lastname: Szkandera
authors.forename: Florentine
authors.initials: F
authors.lastname: Fuerst
authors.forename: Hellmut
authors.initials: H
authors.lastname: Samonigg
authors.forename: Peter
authors.initials: P
authors.lastname: Krippl
authors.forename: Wilfried
authors.initials: W
authors.lastname: Renner
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics*; D039661:Integrin beta3 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000401:mortality; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000964:Antimetabolites, Antineoplastic; D004273:DNA, Neoplasm; C061248:ITGB3 protein, human; D039421:Integrin alpha2; D039661:Integrin beta3; D005472:Fluorouracil