title: Relationship of glomerular filtration rate and serum CK activity after resistance exercise in women.
abstract: The aim of study was to assess the correlation between the changes in serum CK activity after a resistance exercise and renal function measured by glomerular filtration rate (eGFR). Twenty-nine trained women (32 ± 10 years; 157 ± 4 cm; 58.8 ± 6.4 kg) performed a resistance exercise session with 17 exercises with 3 × 12 repetitions in a circuit training fashion. Subjects provided blood samples prior to exercise session (PRE), and at 24, 48, and 72 h following exercise session for creatine kinase (CK) and creatinine. 24-Urine samples were collected before and 72 h after exercises. eGFR was obtained by the three most recommended methods (MDRD; MCQE; Cockcroft-Gault). After the exercise session, serum CK activity increase up 1.68 times (P < 0.01). Serum creatinine increased 25.5% (P = 0.0000) while urinary creatinine decreased on average 6.4% (P = 0.0422). eGFR decreased in all formulas: MDRD by 21.5%, MCQE by 14.2%, and C-G by 17% (all with P < 0.01). Ccr also decreased (-22.9%, P < 0.01). The index of correlation was significant for MDRD (r = -0.924; P < 0.01), C-G (r = -0.884; P < 0.01), and MQCE (r = -0.644; P < 0.05). In conclusion, we observed a significant negative correlation between CK activity and the eGFR indices of renal function.
authors.affiliation: Department of Physical Education, Universitary Foundation of Itaperuna, Itaperuna, Brazil. marcomachado1@gmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Machado
authors.forename: Elida N
authors.initials: EN
authors.lastname: Zini
authors.forename: Samara D
authors.initials: SD
authors.lastname: Valadão
authors.forename: Mayra Z
authors.initials: MZ
authors.lastname: Amorim
authors.forename: Tiago Z
authors.initials: TZ
authors.lastname: Barroso
authors.forename: Wilkes
authors.initials: W
authors.lastname: de Oliveira
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D009211:Myoglobin / Q000097:blood; D012016:Reference Values
chemical_list: D015415:Biomarkers; D009211:Myoglobin; D003404:Creatinine