title: Structure identification of Euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway.
abstract: In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC(50) values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.
authors.affiliation: Department of Pharmaceutical Sciences, School of Basic Science, Guangzhou Medical College, Guangzhou 510182, China. jianyez2003@yahoo.com.cn
authors.forename: Jian-Ye
authors.initials: JY
authors.lastname: Zhang
authors.forename: Yong-Ju
authors.initials: YJ
authors.lastname: Liang
authors.forename: Hu-Biao
authors.initials: HB
authors.lastname: Chen
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Zheng
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Mi
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Zhao
authors.forename: Xiao-Kun
authors.initials: XK
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Li-Wu
authors.initials: LW
authors.lastname: Fu
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D004224:Diterpenes