title: Resistance class 1 integron in clinical methicillin-resistant Staphylococcus aureus strains in southern China, 2001-2006.
abstract: As a novel antibiotic resistance determinant, investigation of the occurrence and characteristics of class 1 integron was performed on nosocomial methicillin-resistant Staphylococcus aureus (MRSA) strains sampled during 2001-2006. Seventy-six out of 179 (42.5%) of the tested strains were found to carry class 1 integrons, with four unique arrays of gene cassettes detected. This is the first report of the comprehensive identification and typing of class 1 integrons in clinical MRSA isolates over a 6-year period, representing the first evidence for class 1 integrons as possible antibiotic resistance determinants in clinical MRSA strains.
authors.affiliation: College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Xu
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: M E
authors.initials: ME
authors.lastname: Shirtliff
authors.forename: B M
authors.initials: BM
authors.lastname: Peters
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Peng
authors.forename: M J
authors.initials: MJ
authors.lastname: Alam
authors.forename: S
authors.initials: S
authors.lastname: Yamasaki
authors.forename: L
authors.initials: L
authors.lastname: Shi
mesh_terms: D015373:Bacterial Typing Techniques; D002681:China; D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D006801:Humans; D032023:Integrons; D016106:Methicillin Resistance / Q000235:genetics; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics* / Q000302:isolation & purification; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*