title: Relationship between prevalence of device-associated infections and alcohol-based hand-rub consumption: a multi-level approach.
abstract: Using a multi-level logistic regression model, we determined whether there was any relationship between alcohol-based hand-rub consumption and prevalence of device-associated infections (DAIs) in French healthcare facilities (HCFs). Two national databases were used: the 2006 French prevalence survey of nosocomial infections, and the 2006 French infection control indicator database which includes alcohol-based hand-rub consumption as an indicator (ICSHA: indicateur de consommation de solution hydro-alcoolique). Only patients with at least one medical device (urinary catheter, vascular catheter or tracheal tube) who were present in an HCF for at least two days were included in the analysis. A multi-level statistical analysis was performed to assess the joint effect of patient-level and hospital-level variables. In all, 814 HCFs, each with a minimum of 15 study patients, were included, giving a total of 53,459 patients. The overall prevalence of DAI was 6.7% (95% confidence interval: 6.4-6.9). The median value of ICSHA was 37.2%. There was no association between DAI prevalence and ICSHA, but all patient-level variables were associated with DAI prevalence. Patient-level variables explain 25% of the hospital-level variation in DAI prevalence, although 60% of this variation remains unexplained when both patient and hospital variables are included in the model. To further assess any association between DAI prevalence and hand hygiene, additional studies on hand hygiene practices specifically associated with invasive medical device manipulation are required.
authors.affiliation: Service d'Hygiène Hospitalière, Centre Hospitalier Universitaire Besançon, France.
authors.forename: C
authors.initials: C
authors.lastname: Slekovec
authors.forename: H
authors.initials: H
authors.lastname: Gbaguidi-Haore
authors.forename: B
authors.initials: B
authors.lastname: Coignard
authors.forename: X
authors.initials: X
authors.lastname: Bertrand
authors.forename: D
authors.initials: D
authors.lastname: Talon
mesh_terms: D000368:Aged; D000438:Alcohols / Q000627:therapeutic use*; D055499:Catheter-Related Infections / Q000453:epidemiology* / Q000517:prevention & control; D002404:Catheterization / Q000009:adverse effects; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002408:Catheters, Indwelling / Q000009:adverse effects*; D003428:Cross Infection / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D005602:France / Q000453:epidemiology; D006235:Hand Disinfection / Q000379:methods*; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D017053:Infection Control / Q000379:methods; D008297:Male; D008875:Middle Aged; D053717:Pneumonia, Ventilator-Associated / Q000453:epidemiology* / Q000517:prevention & control; D015995:Prevalence; D014546:Urinary Catheterization / Q000009:adverse effects; D012122:Ventilators, Mechanical / Q000009:adverse effects*
chemical_list: D000438:Alcohols