title: In vitro and in vivo activities of E-101 solution against Acinetobacter baumannii isolates from U.S. military personnel.
abstract: We evaluated the in vitro and in vivo activity of a novel topical myeloperoxidase-mediated antimicrobial, E-101 solution, against 5 multidrug-resistant Acinetobacter baumannii isolates recovered from wounded American soldiers. Time-kill studies demonstrated rapid bactericidal activity against all A. baumannii strains tested in the presence of 3% blood. The in vitro bactericidal activity of E-101 solution against A. baumannii strains was confirmed in a full-thickness excision rat model. Additional in vivo studies appear warranted.
authors.affiliation: Indiana University Health Pathology Laboratory, Indianapolis, Indiana 46202, USA. gdenys@iuhealth.org
authors.forename: G A
authors.initials: GA
authors.lastname: Denys
authors.forename: J C
authors.initials: JC
authors.lastname: Davis
authors.forename: P D
authors.initials: PD
authors.lastname: O'Hanley
authors.forename: J T
authors.initials: JT
authors.lastname: Stephens
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy*; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000472:pathogenicity*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D008297:Male; D008826:Microbial Sensitivity Tests; D008889:Military Personnel; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000900:Anti-Bacterial Agents