title: Chromatin in the nuclear landscape.
abstract: Chromatin affects many, if not all aspects, of nuclear organization and function. For this reason, we have focused our attention on elucidating some of the basic mechanisms regulating the formation and maintenance of chromatin, specifically concerning Polycomb repressive complex 2 (PRC2) and PR-Set7. PRC2 is responsible for catalyzing trimethylation of lysine 27 of histone H3 and thus has a critical role in the formation of facultative heterochromatin. PR-Set7 is responsible for catalyzing monomethylation of lysine 20 of histone H4 and is required for proper cell cycle progression and DNA damage response. We have also expanded our work to establish novel techniques and approaches to determine how chromatin is spatially regulated within the nuclear landscape.
authors.affiliation: Howard Hughes Medical Institute and Department of Biochemistry, School of Medicine, New York University, New York, New York 10016, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Beck
authors.forename: R
authors.initials: R
authors.lastname: Bonasio
authors.forename: S
authors.initials: S
authors.lastname: Kaneko
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.forename: R
authors.initials: R
authors.lastname: Margueron
authors.forename: H
authors.initials: H
authors.lastname: Oda
authors.forename: K
authors.initials: K
authors.lastname: Sarma
authors.forename: R J
authors.initials: RJ
authors.lastname: Sims
authors.forename: J
authors.initials: J
authors.lastname: Son
authors.forename: P
authors.initials: P
authors.lastname: Trojer
authors.forename: D
authors.initials: D
authors.lastname: Reinberg
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002843:Chromatin / Q000378:metabolism*; D004249:DNA Damage; D006570:Heterochromatin / Q000378:metabolism; D006801:Humans; D063146:Polycomb-Group Proteins; D017434:Protein Structure, Tertiary; D012097:Repressor Proteins / Q000378:metabolism
chemical_list: D002843:Chromatin; D006570:Heterochromatin; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins