title: Effects of comfort food on food intake, anxiety-like behavior and the stress response in rats.
abstract: It has been suggested that access to high caloric food attenuates stress response. The present paper investigates whether access to commercial chow enriched with glucose and fat, here referred to as comfort food alters behavioral, metabolic, and hormonal parameters of rats submitted to three daily sessions of foot-shock stress. Food intake, anxiety-like behaviors, and serum levels of insulin, leptin, corticosterone, glucose and triglycerides were determined. The rats submitted to stress decreased the intake of commercial chow, but kept unaltered the intake of comfort food. During the elevated plus maze (EPM) test, stressed rats increased the number of head dipping, entries into the open arms, as well as the time spent there, and decreased the number of stretched-attend posture and risk assessment. These effects of stress were independent of the type of food consumed. Non-stressed rats ingesting comfort food decreased risk assessment as well. Stress and comfort food increased time spent in the center of the open field and delayed the first crossing to a new quadrant. Stress increased the plasma level of glucose and insulin, and reduced triglycerides, although consumption of comfort food increases glucose, triglyceride and leptin levels; no effect on leptin level was associated to stress. The stress induced increase in serum corticosterone was attenuated when rats had access to comfort food. It was concluded that foot-shock stress has an anorexigenic effect that is independent of leptin and prevented upon access to comfort food. Foot-shock stress also has an anxiolytic effect that is potentiated by the ingestion of comfort food and that is evidenced by both EPM and open field tests.
authors.affiliation: Department of Biosciences, Federal University of São Paulo, Santos, SP, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Ortolani
authors.forename: L M
authors.initials: LM
authors.lastname: Oyama
authors.forename: E M
authors.initials: EM
authors.lastname: Ferrari
authors.forename: L L
authors.initials: LL
authors.lastname: Melo
authors.forename: R C
authors.initials: RC
authors.lastname: Spadari-Bratfisch
mesh_terms: D000818:Animals; D001007:Anxiety / Q000097:blood / Q000503:physiopathology*; D001786:Blood Glucose / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000187:drug effects* / Q000502:physiology; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D007328:Insulin; D020738:Leptin; D014280:Triglycerides; D003345:Corticosterone