title: Prevalence of thyroid autoantibodies in hepatitis C and hepatitis B infection in China.
abstract: OBJECTIVE
  To explore the correlation between anti-thyroid autoantibodies and hepatitis C virus (HCV) infection.
  
  
  METHODS
  We collected 462 samples with positive thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb). Matched for age and gender, 380 subjects with negative TPOAb and TgAb were selected as controls. A third-generation enzyme linked immunosorbent assay (ELISA) was used to examine the presence of anti-HCV antibody. We also examined RNA HCV expression of subjects with positive anti-HCV antibody. Separate groups of 195 subjects with hepatitis C, 150 healthy subjects, and 150 subjects with hepatitis B were tested for thyroid-related markers.
  
  
  RESULTS
  The HCV infection rate was 1.30% in 462 subjects with positive thyroid autoantibodies, and 0.53% in 380 subjects who were negative for thyroid autoantibodies. There was no significant difference in the HCV infection rate between the two groups (χ(2)=1.322, p>0.05). In subjects with hepatitis C, 30.77% were TPOAb positive and 30.77% were TgAb positive; subjects with hepatitis C appeared to show significantly higher positivity of antithyroid autoantibodies when compared with healthy subjects and those with hepatitis B (χ(2)=21.496, χ(2)=30.454, p<0.01).
  
  
  CONCLUSIONS
  The HCV infection rate did not seem to be higher in subjects with abnormal thyroid autoimmunity. However, the positivity of thyroid autoantibodies appeared to be increased in subjects with hepatitis C, suggesting that thyroid-related markers should be examined in hepatitis C patients.
authors.affiliation: Department of Endocrinology, Institute of Endocrinology, First Affiliated Hospital of China Medical University, The Liaoning Provincial Key Laboratory of Endocrine diseases, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Shan
authors.forename: Yushu
authors.initials: Y
authors.lastname: Li
authors.forename: Chenling
authors.initials: C
authors.lastname: Fan
authors.forename: Chenyang
authors.initials: C
authors.lastname: Li
authors.forename: Weiping
authors.initials: W
authors.lastname: Teng
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D033862:Iron-Binding Proteins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D013954:Thyroglobulin / Q000276:immunology; D013959:Thyroid Diseases / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D018937:Hepatitis C Antibodies; D033862:Iron-Binding Proteins; D012367:RNA, Viral; C006606:anti-thyroglobulin; C056626:thyroid microsomal antibodies; D013954:Thyroglobulin; C056658:TPO protein, human; D007453:Iodide Peroxidase