title: [Liver histology and surgical outcomes after preoperative chemotherapy in colorectal cancer liver metastases].
abstract: We aimed to assess hepatic histopathological responses to preoperative chemotherapy in patients with colorectal liver metastasis. We selected all patients(n=34)with colorectal liver metastases between September 2006 and March 2009. The preoperative chemotherapy group was significantly associated with tumor regression, inflammatory response, sinusoidal dilatation compared with non-chemotherapy group. There was no difference in the rate of postoperative complications and hospital stay. Prolonged preoperative systemic chemotherapy alters liver parenchyma, but it does not increase postoperative complications. This should be taken into consideration before deciding a major liver resection in patients who have received preoperative chemotherapy.
authors.affiliation: Dept. of Surgery, Kurume University School of Medicine, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Hisaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Horiuchi
authors.forename: Shinji
authors.initials: S
authors.lastname: Uchida
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ogata
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Akagi
authors.forename: Nobuya
authors.initials: N
authors.lastname: Ishibashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kawahara
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Maruyama
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Mikagi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kawashima
authors.forename: Manami
authors.initials: M
authors.lastname: Fujishita
authors.forename: Daimei
authors.initials: D
authors.lastname: Eto
authors.forename: Munehiro
authors.initials: M
authors.lastname: Yoshidomi
authors.forename: Rin
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Yano
authors.forename: Hisafumi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shirozu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011183:Postoperative Complications; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents