title: Fourteen-year-old girl with recurrent luteal-phase-dependent episodes of high fever.
abstract: Recurrent episodes of high fever during the luteal phase are exceedingly rare. A 14-year-old girl with a 1-year history of recurrent febrile episodes associated with the menstrual cycle was referred to our department. Febrile episode (39-41°C) occurred for 10 to 12 days concomitantly with the luteal phase of each ovulatory cycle. To suppress the ovulatory cycle, gonadotropin releasing hormone agonist was administered for 5 months, and then febrile attack disappeared (34.5-36.2°C). Before and during gonadotropin releasing hormone agonist therapy, serum levels of inflammatory cytokines (interleukin [IL]-1β, IL-2, IL-6, IL-8, IL-10, and tumor necrosis factor-α) were unchanged and all of these were within the normal ranges. In our case, luteal-phase-dependent febrile episodes may not be attributable to the intervention of inflammatory cytokines as major fever mediators.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Oki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Iwamoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Douchi
mesh_terms: D000293:Adolescent; D016207:Cytokines / Q000097:blood; D005260:Female; D005334:Fever / Q000097:blood / Q000209:etiology* / Q000517:prevention & control*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D008183:Luteal Phase / Q000097:blood; D034445:Ovulation Inhibition; D055502:Secondary Prevention; D012720:Severity of Illness Index
chemical_list: D016207:Cytokines; D007987:Gonadotropin-Releasing Hormone