title: [Effect of radio-ecological conditions in the ChNPP exclusion zone on morphofunctional state and responsiveness of organs and tissues of laboratory animals].
abstract: The state of hematopoietic, reproductive and endocrine systems of the organisms of male rats and their offspring in generations (F0-F1-F2) was studied, and the sensitivity of an organism to the action of carcinogen (Af mice) after a stay in the ChNPP exclusion zone was analyzed. It was ascertained that the most significant changes of the morphofunctional state of the animals were observed in the II generation (F2), which remained for a long period under the conditions of radioactive contamination. We have revealed an increased number of leukocytes, neutrophils, lymphocytes, and, especially, monocytes as against while the decrease in the number of erythrocytes and haemoglobin content; the decrease of thyroid function and cortical layer of the adrenals as opposed to while the increase in the relative weight of testes and their epididymides and the decrease in the number of spermatocytes and spermatozoa in the testis tissue. The exposure of Af mice in the exclusion zone increases the processes of mutagenesis and carcinogenesis, and changes the organism response to standardized action of chemical carcinogen. The increase in the exposure time of animals intensifies metabolic processes in a cell and increases their sensitivity to the action of xenobiotics.
authors.forename: E F
authors.initials: EF
authors.lastname: Konoplia
authors.forename: G G
authors.initials: GG
authors.lastname: Vereshchako
authors.forename: G A
authors.initials: GA
authors.lastname: Gorokh
authors.forename: A F
authors.initials: AF
authors.lastname: Malenchenko
authors.forename: S N
authors.initials: SN
authors.lastname: Sushko
authors.forename: O L
authors.initials: OL
authors.lastname: Fedosenko
authors.forename: N V
authors.initials: NV
authors.lastname: Gun'kova
authors.forename: A E
authors.initials: AE
authors.lastname: Kozlov
authors.forename: A O
authors.initials: AO
authors.lastname: Savin
authors.forename: E M
authors.initials: EM
authors.lastname: Kadukova
authors.forename: A D
authors.initials: AD
authors.lastname: Naumov
authors.forename: N I
authors.initials: NI
authors.lastname: Timokhina
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D002118:Calcium / Q000097:blood; D002286:Carcinoma, Ehrlich Tumor / Q000209:etiology*; D047852:Chernobyl Nuclear Accident; D003043:Cocarcinogenesis; D004307:Dose-Response Relationship, Radiation; D004703:Endocrine System / Q000254:growth & development / Q000528:radiation effects; D004912:Erythrocytes / Q000528:radiation effects; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009929:Organ Size / Q000528:radiation effects; D010758:Phosphorus / Q000097:blood; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood* / Q000235:genetics / Q000473:pathology; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000235:genetics / Q000473:pathology; D051381:Rats; D012098:Reproduction / Q000528:radiation effects; D012669:Seminal Vesicles / Q000254:growth & development / Q000528:radiation effects; D016019:Survival Analysis; D013737:Testis / Q000254:growth & development / Q000528:radiation effects
chemical_list: D010758:Phosphorus; D002118:Calcium