title: Gram-negative neonatal osteomyelitis: two case reports.
abstract: Neonatal osteomyelitis is a rare and challenging diagnosis, particularly in the early onset period. Neonatal osteomyelitis is predominantly caused by Staphylococcus aureus with single bone involvement. Here, we report two cases of neonatal osteomyelitis in premature infants caused by Klebsiella pneumoniae with multiple bone lesions. Both cases presented with sepsis and meningitis and were initially diagnosed by incidental findings on plain films, with follow-up bone scan imaging. In both cases, diagnosis was timely and treatment was successful. These cases highlight the need to include neonatal osteomyelitis in the differential diagnosis when late-onset or prolonged neonatal sepsis is present, particularly because long-term outcome is dependent on rapid diagnosis and initiation of treatment.
authors.affiliation: Neonatal Department, Children's Hospital of Fudan University, Shanghai, China. zhang-jin-ping@163.com
authors.forename: Jinping
authors.initials: J
authors.lastname: Zhang
authors.forename: Ben H
authors.initials: BH
authors.lastname: Lee
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007710:Klebsiella Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D007711:Klebsiella pneumoniae / Q000302:isolation & purification*; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications / Q000175:diagnosis / Q000382:microbiology; D010019:Osteomyelitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D018805:Sepsis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome