title: [Transversal study on the prevalence of Metabolic Bone Disease (MBD) and Home Parenteral Nutrition (HPN) in Spain: data from NADYA group].
abstract: Patients with intestinal failure who receive HPN are at high risk of developing MBD. The origin of this bone alteration is multifactorial and depends greatly on the underlying disease for which the nutritional support is required. Data on the prevalence of this disease in our environment is lacking, so NADYA-SEMPE group has sponsored this transversal study with the aim of knowing the actual MBD prevalence.
  
  
  METHODS
  Retrospective data from 51 patients from 13 hospitals were collected. The questionnaire included demographic data as well as the most clinically relevant for MBD data. Laboratory data (calciuria, PTH, 25 -OH -vitamin D) and the results from the first and last bone densitometry were also registered.
  
  
  RESULTS
  Bone mineral density had only been assessed by densitometry in 21 patients at the moment HPN was started. Bone quality is already altered before HPN in a significant percentage of cases (52%). After a mean follow up of 6 years, this percentage increases up to 81%. Due to retrospective nature of the study and the low number of subjects included it has not been possible to determine the role that HPN plays in MBD etiology. Only 35% of patients have vitamin D levels above the recommended limits and the majority of them is not on specific supplementation.
  
  
  CONCLUSIONS
  HPN is associated with very high risk of MBD, therefore, management protocols that can lead to early detection of the problem as well as guiding for follow up and treatment of these patients are needed.
authors.affiliation: Hospital Universitario Central de Asturias, Oviedo, España. ceferinofaedo@yahoo.es
authors.forename: C
authors.initials: C
authors.lastname: Martínez
authors.forename: N
authors.initials: N
authors.lastname: Virgili
authors.forename: C
authors.initials: C
authors.lastname: Cuerda
authors.forename: L
authors.initials: L
authors.lastname: Chicharro
authors.forename: P
authors.initials: P
authors.lastname: Gómez
authors.forename: J M
authors.initials: JM
authors.lastname: Moreno
authors.forename: J
authors.initials: J
authors.lastname: Álvarez
authors.forename: E
authors.initials: E
authors.lastname: Martí
authors.forename: P
authors.initials: P
authors.lastname: Matía
authors.forename: M A
authors.initials: MA
authors.lastname: Penacho
authors.forename: C
authors.initials: C
authors.lastname: Garde
authors.forename: D
authors.initials: D
authors.lastname: De Luis
authors.forename: M
authors.initials: M
authors.lastname: Gonzalo
authors.forename: G
authors.initials: G
authors.lastname: Lobo
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000453:epidemiology* / Q000209:etiology*; D003720:Densitometry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D018529:Nutritional Support; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology; D016331:Parenteral Nutrition, Home / Q000009:adverse effects*; D012189:Retrospective Studies; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology; D014808:Vitamin D Deficiency / Q000453:epidemiology / Q000209:etiology; D055815:Young Adult