title: Compositae-associated allergic contact dermatitis from bisabolol.
abstract: BACKGROUND
  Compositae-related chemicals cause allergic contact dermatitis (ACD) in children with atopic dermatitis (AD). Moisturizers can be an overlooked exposure source.
  
  
  OBJECTIVE
  To evaluate ACD in children with recalcitrant AD and a reported history of intolerance to Aquaphor Healing Ointment (AHO) moisturizer.
  
  
  METHODS
  We retrospectively reviewed charts of children patch-tested to the ingredients of AHO moisturizer who had a history of intolerance, as well as of additional patch-tested patients with exposure to bisabolol in their personal hygiene products and without a history of product intolerance.
  
  
  RESULTS
  Seven patients, six of whom had AD, had been referred to our clinic with a history of intolerance to the moisturizer. They were patch-tested with their moisturizer and the components provided by Beiersdorf. Of these, four had positive reactions to their AHO moisturizer and to bisabolol, a Compositae derivative.
  
  
  CONCLUSIONS
  Bisabolol, a sesquiterpene alcohol, should be considered a potential cause of ACD in children with AD and a history of moisturizer intolerance.
authors.affiliation: Division of Pediatric and Adolescent Dermatology, Rady Children’s Hospital, University of California, San Diego, San Diego, CA, USA.
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Jacob
authors.forename: Catalina
authors.initials: C
authors.lastname: Matiz
authors.forename: Elise M
authors.initials: EM
authors.lastname: Herro
mesh_terms: D000293:Adolescent; D019659:Asteraceae / Q000737:chemistry*; D002648:Child; D002675:Child, Preschool; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D000081222:Monocyclic Sesquiterpenes; D009824:Ointments; D010328:Patch Tests; D012189:Retrospective Studies; D012717:Sesquiterpenes / Q000009:adverse effects*
chemical_list: D003879:Dermatologic Agents; D000081222:Monocyclic Sesquiterpenes; D009824:Ointments; D012717:Sesquiterpenes; C004497:bisabolol