title: Dysregulated neutrophil--endothelial interaction in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides: implications for pathogenesis and disease intervention.
abstract: The interplay between neutrophils and endothelial cells allows ANCA to become pathogenic and results in uncontrolled inflammation in the vessel wall. This review presents an overall view on neutrophil-endothelial interaction during inflammation with a focus on ANCA-associated vasculitis, and summarizes the effector mechanisms which cause vascular damage in AAV. In addition, potential elements for disease intervention based on this process are discussed.
authors.affiliation: Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Nan
authors.initials: N
authors.lastname: Hu
authors.forename: Johanna
authors.initials: J
authors.lastname: Westra
authors.forename: Cees G M
authors.initials: CG
authors.lastname: Kallenberg
mesh_terms: D000818:Animals; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000276:immunology* / Q000503:physiopathology* / Q000628:therapy; D015815:Cell Adhesion Molecules / Q000276:immunology; D002450:Cell Communication / Q000276:immunology; D042783:Endothelial Cells / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation; D009504:Neutrophils / Q000276:immunology*; D014652:Vascular Diseases / Q000276:immunology / Q000503:physiopathology
chemical_list: D015815:Cell Adhesion Molecules