title: Immunologic profile of excessive body weight.
abstract: The purpose of this paper is to identify immunologic hallmarks of excessive bodyweight. The analysis is based on 176 adults (106 women, 70 men) who participated in a nested case-control study in Italy. All participants were healthy at the time of blood collection and aged between 36 and 75 years. We employed multivariate analysis of variance and a nonparametric Bayesian additive regression tree approach along with a receiver operating characteristic (ROC) curve analysis to determine the immunologic signature of excessive body weight (i.e., obesity and overweight). Interleukin 8 (IL-8), IL-10, interferon γ, and inducible protein 10 were shown to be predictive of excessive body weight with an area under the ROC curve of 71% (p < 0.0002). We propose that by using this profile-based approach to define immunologic signatures, it might be possible to identify unique immunologic hallmarks of specific types of obesity.
authors.affiliation: School of Public Health, Imperial College London, London, UK.
authors.forename: Mansour Taghavi Azar
authors.initials: MT
authors.lastname: Sharabiani
authors.forename: Roel
authors.initials: R
authors.lastname: Vermeulen
authors.forename: Chiara
authors.initials: C
authors.lastname: Scoccianti
authors.forename: Fatemeh Saberi
authors.initials: FS
authors.lastname: Hosnijeh
authors.forename: Liliana
authors.initials: L
authors.lastname: Minelli
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Paolo
authors.initials: P
authors.lastname: Chiodini
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
mesh_terms: D015415:Biomarkers / Q000097:blood; D001835:Body Weight / Q000276:immunology; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000276:immunology*; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D018799:Intercellular Adhesion Molecule-1