title: High plasma level of factor VIII: an important risk factor for venous thromboembolism.
abstract: BACKGROUND
  Elevated levels of factor VIII (FVIII) have been suggested as important for the pathogenesis of venous thromboembolism (VTE). The objective of this study was to explore the association between elevated FVIII level and VTE in Japan.
  
  
  RESULTS
  68 patients with objectively documented VTE and 40 controls were included. In the patients, the FVIII level was measured for a mean follow-up period of 52.6 months (3-348 months) after the onset of VTE, in order to avoid an acute-phase response. The VTE patients had a higher mean FVIII level than the controls (154.5 ± 55.8 IU/dl vs. 114.3 ± 16.0 IU/dl, P < 0.0001). According to multivariate analysis, FVIII levels above the 50(th) percentile (124 IU/dl) conferred an odds ratio of 4.9 (95% confidence intervals (CI) 1.9-12.4; P < 0.001) and those above the 75(th) percentile (150 IU/dl) conferred an odds ratio of 31.9 (95%CI 4.0-252.3; P < 0.001).
  
  
  CONCLUSIONS
  Elevated plasma FVIII level is a risk factors for VTE in Japanese people, and FVIII levels above the 75(th) percentile are associated with a significant odds ratio for the occurrence of VTE.
authors.affiliation: Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.forename: Norikazu
authors.initials: N
authors.lastname: Yamada
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Ogihara
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tsuji
authors.forename: Ken
authors.initials: K
authors.lastname: Ishikura
authors.forename: Mashio
authors.initials: M
authors.lastname: Nakamura
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ito
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D015854:Up-Regulation; D054556:Venous Thromboembolism / Q000097:blood / Q000208:ethnology / Q000209:etiology*
chemical_list: D015415:Biomarkers; D005169:Factor VIII