title: Effect of induction dose, lactation stage and body condition on tiletamine-zolazepam anaesthesia in adult female grey seals (Halichoerus grypus) under field conditions.
abstract: Tiletamine-zolazepam (TZ) was used at a mean (sd) dose of 1.18 (0.15) mg/kg administered intramuscularly to anaesthetise adult female grey seals (Halichoerus grypus) under field conditions at three different stages during their lactation period. A significant correlation was observed between the induction dose and time to induction (r=-0.582, P=0.011). Stage of lactation had a significant effect on condition index (CI), calculated as axial girth divided by length (P<0.001), and time to induction (P=0.009). No effect of CI on induction or recovery time was demonstrated. Respiratory rate decreased during induction and increased significantly (P<0.001) during surgical biopsy of blubber. Recovery occurred after 32.5 (11.9) minutes. Minor complications (tremor, vocalisation and mild dyspnoea) were observed in a small number of cases, none of which required treatment.
authors.affiliation: Royal Veterinary College, North Mymms, Hertfordshire, UK. s.langton@vet.gla.ac.uk
authors.forename: S D
authors.initials: SD
authors.lastname: Langton
authors.forename: S E
authors.initials: SE
authors.lastname: Moss
authors.forename: P P
authors.initials: PP
authors.lastname: Pomeroy
authors.forename: K E
authors.initials: KE
authors.lastname: Borer
mesh_terms: D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000777:Anesthetics / Q000008:administration & dosage*; D000827:Animal Welfare; D000818:Animals; D000835:Animals, Wild; D001824:Body Constitution / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D007262:Infusions, Intravenous / Q000662:veterinary; D007774:Lactation / Q000502:physiology*; D056152:Respiratory Rate / Q000187:drug effects; D046048:Seals, Earless / Q000502:physiology*; D013992:Tiletamine / Q000008:administration & dosage*; D015041:Zolazepam / Q000008:administration & dosage*
chemical_list: D000777:Anesthetics; D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D013992:Tiletamine; D015041:Zolazepam