title: Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study.
abstract: BACKGROUND
  We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men.
  
  
  METHODS
  Healthy men (n = 576, 30 ~ 79 years old) were genotyped for rs174537 near FADS1 (FEN1-10154G>T), FADS2 (rs174575C>G, rs2727270C>T), and FADS3 (rs1000778C>T) SNPs. Dietary intake, serum phospholipid FA composition and HOMA-IR were measured.
  
  
  RESULTS
  Fasting insulin and HOMA-IR were significantly higher in the rs174575G allele carriers than the CC homozygotes, but lower in the rs2727270T allele carriers than the CC homozygotes. The proportion of linoleic acid (18:2ω-6, LA) was higher in the minor allele carriers of FEN1-10154G>T, rs174575C>G and rs2727270C>T than the major homozygotes, respectively. On the other hand, the proportions of dihomo-γ-linolenic acid (20:3ω-6, DGLA) and arachidonic acid (20:4ω-6, AA) in serum phospholipids were significantly lower in the minor allele carriers of FEN1-10154 G>T carriers and rs2727270C>T than the major homozygotes respectively. AA was also significantly lower in the rs1000778T allele carriers than the CC homozygotes. HOMA-IR positively correlated with LA and DGLA and negatively with AA/DGLA in total subjects. Interestingly, rs174575G allele carriers showed remarkably higher HOMA-IR than the CC homozygotes when subjects had higher proportions of DLGA (≥1.412% in total serum phospholipid FA composition) (P for interaction = 0.009) or of AA (≥4.573%) (P for interaction = 0.047).
  
  
  CONCLUSIONS
  HOMA-IR is associated with FADS gene cluster as well as with FA composition in serum phospholipids. Additionally, HOMA-IR may be modulated by the interaction between rs174575C>G and the proportion of DGLA or AA in serum phospholipids.
authors.affiliation: Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea.|Clinical Nutrigenetics/Nutrigenomics Lab, Dept of Food and Nutrition, Yonsei University, Seoul, Korea.
authors.forename: Oh Yoen
authors.initials: OY
authors.lastname: Kim
authors.affiliation: Clinical Nutrigenetics/Nutrigenomics Lab, Dept of Food and Nutrition, Yonsei University, Seoul, Korea.
authors.forename: Hyo Hee
authors.initials: HH
authors.lastname: Lim
authors.affiliation: Clinical Nutrigenetics/Nutrigenomics Lab, Dept of Food and Nutrition, Yonsei University, Seoul, Korea.
authors.forename: Long In
authors.initials: LI
authors.lastname: Yang
authors.affiliation: Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea.|Clinical Nutrigenetics/Nutrigenomics Lab, Dept of Food and Nutrition, Yonsei University, Seoul, Korea.
authors.forename: Jey Sook
authors.initials: JS
authors.lastname: Chae
authors.affiliation: Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea.|Clinical Nutrigenetics/Nutrigenomics Lab, Dept of Food and Nutrition, Yonsei University, Seoul, Korea.
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee