title: A highly conjugated dihydroxylated C28 steroid from a myxobacterium.
abstract: In the course of our search for novel secondary metabolites, the CHCl3-MeOH extract of the novel myxobacterial strain Sorangiineae SBNa008 was shown to be active against human SW480 colon adinocarcinoma cells. Bioassay-guided fractionation of the extract yielded a highly conjugated novel, sterol 9α,11α-dihydroxyergosta-4,6,8(14),22-tetraen-3-one, 1. The structure and the relative stereochemistry of 1 were established from interpretation of spectroscopic data and X-ray crystallography.
authors.affiliation: Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, Campus C2 3, 66123 Saarbrücken, Germany.
authors.forename: Dnyaneshwar
authors.initials: D
authors.lastname: Gawas
authors.forename: Ronald
authors.initials: R
authors.lastname: Garcia
authors.forename: Volker
authors.initials: V
authors.lastname: Huch
authors.forename: Rolf
authors.initials: R
authors.lastname: Müller
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry*
chemical_list: C560172:9alpha,11alpha-dihydroxyergosta-4,6,8(14),22-tetraen-3-one; D000970:Antineoplastic Agents; C015190:ergostane; D004875:Ergosterol