title: Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water.
abstract: The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats. Using DNA microarrays, 548 upregulated and 695 downregulated genes were detected in the liver after 4 weeks of administration of hydrogen water. Gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including hydroxymethylglutaryl CoA reductase, were significantly enriched in the upregulated genes.
authors.affiliation: Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan. aynakai@mail.ecc.u-tokyo.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakai
authors.forename: Bunpei
authors.initials: B
authors.lastname: Sato
authors.forename: Shota
authors.initials: S
authors.lastname: Ushiama
authors.forename: Shinji
authors.initials: S
authors.lastname: Okada
authors.forename: Keiko
authors.initials: K
authors.lastname: Abe
authors.forename: Soichi
authors.initials: S
authors.lastname: Arai
mesh_terms: D000818:Animals; D004326:Drinking; D006859:Hydrogen / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015854:Up-Regulation / Q000187:drug effects*; D014867:Water / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D014867:Water; D006859:Hydrogen