title: Development of cellular therapy for the treatment of stress urinary incontinence.
abstract: Stress urinary incontinence (SUI) is highly prevalent and associated with a reduced quality of life. An intact rhabdosphincter at the mid-urethra is mandatory to maintain urinary continence. Adult stem cell injection therapy for the regenerative repair of an impaired sphincter is currently at the forefront of incontinence research. The implanted cells will fuse with muscle and release trophic factors promoting nerve and muscle integration. Hereby, we review the use of mesenchymal stem cell therapy for SUI and the experience with the development of muscle-derived stem cells.
authors.affiliation: Department of Urology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Hung-Jen
authors.initials: HJ
authors.lastname: Wang
authors.forename: Yao-Chi
authors.initials: YC
authors.lastname: Chuang
authors.forename: Michael B
authors.initials: MB
authors.lastname: Chancellor
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D001854:Bone Marrow Cells; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D009132:Muscles / Q000166:cytology* / Q000294:innervation; D032446:Myoblasts / Q000637:transplantation; D014521:Urethra / Q000294:innervation / Q000503:physiopathology*; D014550:Urinary Incontinence, Stress / Q000503:physiopathology* / Q000628:therapy*