title: Pathogen yield and antimicrobial resistance patterns of chronic rhinosinusitis patients presenting to a tertiary rhinology centre.
abstract: OBJECTIVE
  To examine the yield and resistance profile of pathogens in chronic rhinosinusitis (CRS) patients receiving culture-directed management and to pay particular attention to the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in this population.
  
  
  METHODS
  Retrospective review of a CRS microbiology database.
  
  
  METHODS
  Consecutive CRS patients seen at the St. Paul's Sinus Centre between June 2007 and August 2008.
  
  
  METHODS
  Canadian tertiary sinus centre.
  
  
  METHODS
  To determine the pathogens isolated, the frequency of these pathogens, and their resistance profiles.
  
  
  RESULTS
  The most common bacterial pathogens isolated were Staphylococcus aureus, accounting for 39% of cultured samples, followed by Haemophilus influenzae (29%), Pseudomonas aeruginosa (15%), Streptococcus pneumoniae (12%), and Moraxella catarrhalis (11%). Only three cases of MRSA were found, one in a patient with cystic fibrosis.
  
  
  CONCLUSIONS
  MRSA does not appear to pose a significant risk of morbidity in our patient population. However, ongoing concern regarding the increasing prevalence of S. aureus and antimicrobial resistance in chronic sinonasal disease highlights the importance of using culture-directed antimicrobial therapy with the goal of minimizing future resistance patterns.
authors.affiliation: Department of Surgery, University of British Columbia, St. Paul's Sinus Centre, St. Paul's Hospital, Vancouver, BC.
authors.forename: Krista A
authors.initials: KA
authors.lastname: Genoway
authors.forename: Carl M
authors.initials: CM
authors.lastname: Philpott
authors.forename: Amin R
authors.initials: AR
authors.lastname: Javer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000302:isolation & purification*; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012220:Rhinitis / Q000188:drug therapy / Q000382:microbiology*; D012852:Sinusitis / Q000188:drug therapy / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents