title: Dearomatization strategies in the synthesis of complex natural products.
abstract: Evolution in the field of the total synthesis of natural products has led to exciting developments over the last decade. Numerous chemoselective and enantioselective methodologies have emerged from total syntheses, resulting in efficient access to many important natural product targets. This Review highlights recent developments concerning dearomatization, a powerful strategy for the total synthesis of architecturally complex natural products wherein planar, aromatic scaffolds are converted to three-dimensional molecular architectures.
authors.affiliation: Department of Chemistry, Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA.
authors.forename: Stéphane P
authors.initials: SP
authors.lastname: Roche
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry; D010636:Phenols / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D005663:Furans; D007211:Indoles; D010636:Phenols; D011758:Pyrroles