title: [Synthetic peptide vaccines].
abstract: This review considers the stages of the development of synthetic peptide vaccines against infectious agents, novel approaches and technologies employed in this process, including bioinformatics, genomics, proteomics, large-scale peptide synthesis, high-throughput screening methods, the use of transgenic animals for modelling human infections. An important role for the development and selection of efficient adjuvants for peptide immunogens is noted. Examples of synthetic peptide vaccine developments against three infectious diseases (malaria, hepatitis C, and foot-and-mouth disease) are given.
authors.forename: A A
authors.initials: AA
authors.lastname: Moĭsa
authors.forename: E F
authors.initials: EF
authors.lastname: Kolesanova
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D005536:Foot-and-Mouth Disease / Q000276:immunology / Q000517:prevention & control*; D006526:Hepatitis C / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000138:chemical synthesis / Q000276:immunology* / Q000494:pharmacology; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology* / Q000494:pharmacology; D014614:Vaccines, Synthetic / Q000276:immunology / Q000494:pharmacology; D014761:Viral Hepatitis Vaccines / Q000138:chemical synthesis / Q000276:immunology* / Q000494:pharmacology
chemical_list: D017780:Malaria Vaccines; D010455:Peptides; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines