title: DNA damage discrimination at stalled replication forks by the Rad5 homologs HLTF and SHPRH.
abstract: In this issue of Molecular Cell, Lin et al. (2011) describe how HLTF and SHPRH, the human homologs of yeast Rad5, can discriminate between MMS-induced versus UV-induced DNA damage. The results have important implications for the suppression of damage-specific mutagenesis and for the maintenance of genomic stability.
authors.affiliation: Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02215, USA.
authors.forename: George-Lucian
authors.initials: GL
authors.lastname: Moldovan
authors.forename: Alan D
authors.initials: AD
authors.lastname: D'Andrea