title: [The activity of 2',5'-oligoadenylate-synthetase in rat spleen lymphocytes in the chronic ethanol intoxication and administration of zinc acetate].
abstract: It was shown that the activity of interferon-induced enzyme 2',5'-oligoadenylate-synthetase is suppressed in rat spleen lymphocytes under the chronic alcohol intoxication. The values of enzyme activity were minimal under the long-term action of etanol (21 day). The combined administration of zinc acetate and etanol to rats causes the increase of enzyme activity, the effect is most expressed on the late stages of alcohol intoxication development.
authors.forename: V O
authors.initials: VO
authors.lastname: Chaĭka
authors.forename: I V
authors.initials: IV
authors.lastname: Kompanets'
authors.forename: O P
authors.initials: OP
authors.lastname: Hadiliia
authors.forename: O I
authors.initials: OI
authors.lastname: Kharchenko
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism*; D000437:Alcoholism / Q000201:enzymology* / Q000276:immunology / Q000517:prevention & control; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D019345:Zinc Acetate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000431:Ethanol; D015088:2',5'-Oligoadenylate Synthetase; D019345:Zinc Acetate