title: New multicomponent cyclization: domino synthesis of pentasubstituted pyridines under solvent-free conditions.
abstract: An efficient methodology for the synthesis of highly functionalized pyridine derivatives starting from readily available common reactants has been developed under microwave irradiation and solvent-free conditions. The new domino reaction enables successful assembly of five new σ bonds including two C-N bonds in a one-pot operation. A new mechanism has been proposed, which involves a novel reaction and sequence consisting of deprotonation-imine formation-anionic carbonyl addition.
authors.affiliation: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, Jiangsu, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
mesh_terms: D018360:Crystallography, X-Ray; D003500:Cyclization; D008872:Microwaves; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011725:Pyridines