title: Efficacy of surgery for lung metastases from colorectal cancer synchronous to or following that for liver metastases.
abstract: OBJECTIVE
  To evaluate the validity of surgical therapy for isolated hepatic and pulmonary colorectal metastases.
  
  
  METHODS
  Among 256 patients with liver resection for colorectal cancer metastases, 31 patients underwent resection for lung metastases synchronously or following liver resection.
  
  
  RESULTS
  Twenty-nine patients (93.5%) underwent pulmonary resection for lung metastases after hepatectomy. Two patients (6.5%) with synchronously identified liver and lung metastases underwent staged liver and lung resection. The 5-, and 10-year overall survival rates were 77.5% and 39.5% after the initial liver resection and were 44.7% and 38.2% after the pulmonary resection, respectively. By multivariate analysis, the presence of three or more pulmonary metastases (risk ratio=3.692, 95% confidence interval C I=1.039-13.118, p=0.043) was an independent adverse prognostic factor.
  
  
  CONCLUSIONS
  Surgical resection for both hepatic and pulmonary metastases from colorectal cancer appears feasible and efficacious in patients with <3 pulmonary metastases.
authors.affiliation: Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, 236-0004 3-9 Fukuura, Kanazawa-ku, Yokohama City, Japan. noji1192@yokohama-cu.ac.jp
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nojiri
authors.forename: Kuniya
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nagano
authors.forename: Michio
authors.initials: M
authors.lastname: Ueda
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsuo
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Ota
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimada
authors.forename: Itaru
authors.initials: I
authors.lastname: Endo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D003710:Demography; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008175:Lung Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000601:surgery*; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D016896:Treatment Outcome