title: Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction.
abstract: A total synthesis of LL-Z1640-2 (2), a potent and selective kinase inhibitor, has been completed. The key step of the convergent synthesis utilized a late-stage intramolecular Nozaki-Hiyama-Kishi (NHK) reaction to close the macrocycle at the C6'-C7' bond.
authors.affiliation: NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Leclair
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Boxer
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Thomas
authors.forename: David J
authors.initials: DJ
authors.lastname: Maloney