title: Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patients.
abstract: Coenzyme Q(10) (CoQ(10)) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Low CoQ(10) levels have been detected in patients with Fibromyalgia (FM). The purpose of the present work was to assess the effect of CoQ(10) on symptoms of five patients with FM. Patients were evaluated clinically with Visual Analogical Scale of pain (VAS), and Fibromyalgia Impact Questionnaire (FIQ). Patients with CoQ(10) deficiency showed a statistically significant reduction on symptoms after CoQ(10) treatment during 9 months (300 mg/day). Determination of deficiency and consequent supplementation in FM may result in clinical improvement. Further analysis involving more scientifically rigorous methodology will be required to confirm this observation.
authors.affiliation: Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC, Sevilla, Spain. mdcormor@upo.es
authors.forename: Mario D
authors.initials: MD
authors.lastname: Cordero
authors.forename: Elísabet
authors.initials: E
authors.lastname: Alcocer-Gómez
authors.forename: Manuel
authors.initials: M
authors.lastname: de Miguel
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Cano-García
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Luque
authors.forename: Patricia
authors.initials: P
authors.lastname: Fernández-Riejo
authors.forename: Ana María Moreno
authors.initials: AM
authors.lastname: Fernández
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Sánchez-Alcazar
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use; D005260:Female; D005356:Fibromyalgia / Q000188:drug therapy*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D028361:Mitochondrial Diseases / Q000188:drug therapy*; D018384:Oxidative Stress; D010147:Pain Measurement; D010361:Patients; D010949:Plasma / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D014451:Ubiquinone; C024989:coenzyme Q10