title: Glucosyloxybenzyl eucomate derivatives from Vanda teres stimulate HaCaT cytochrome c oxidase.
abstract: Eucomic acid [(2R)-2-(p-hydroxybenzyl)malic acid)] (1) and three new glucopyranosyloxybenzyl eucomate derivatives, vandaterosides I (2), II (3), and III (4), were isolated and identified from the stems of Vanda teres. Their cellular antiaging properties were evaluated in a human immortalized keratinocyte cell line (HaCaT) by monitoring their effect on cytochrome c oxidase activity, implicated in mitochondrial respiratory function and cellular energy production. Eucomic acid (1) and vandateroside II (3) increased cytochrome c oxidase activity and/or expression, without enhancing cellular mitochondrial content. These two V. teres biomarkers apparently contributed to stimulate respiratory functions in keratinocytes. Since aging and its pathologies may be ascribed to a decline in mitochondrial functions, these biomarkers have the potential to become new natural ingredients for antiaging preparations to remedy age-related disorders such as skin aging.
authors.affiliation: Faculty of Pharmacy, Strasbourg University, 67400 Illkirch, France. charlotte.simmler@pharma.u-strasbg.fr
authors.forename: Charlotte
authors.initials: C
authors.lastname: Simmler
authors.forename: Cyril
authors.initials: C
authors.lastname: Antheaume
authors.forename: Patrice
authors.initials: P
authors.lastname: André
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bonté
authors.forename: Annelise
authors.initials: A
authors.lastname: Lobstein
mesh_terms: D003576:Electron Transport Complex IV / Q000187:drug effects* / Q000378:metabolism; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D057888:Iridoid Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015603:Keratinocytes / Q000187:drug effects; D008293:Malates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008928:Mitochondria / Q000378:metabolism; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D013785:Thailand
chemical_list: D005960:Glucosides; D057888:Iridoid Glucosides; D008293:Malates; C000608334:vandateroside I; C000608335:vandateroside II; D003576:Electron Transport Complex IV