title: [Effect of Ziyinqingsang decoction on interleukin-4 and -5 levels in peripheral blood mononuclear cells of children in acute stage of cough variant asthma].
abstract: OBJECTIVE
  To observe the effect of Ziyinqingsang decoction on the levels of interleukin-4 (IL-4) and IL-5 in the peripheral blood mononuclear cells (PBMCs) in children with cough variant asthma (CVA) in the acute stage.
  
  
  METHODS
  Thirty children with CVA in the acute stage were given Ziyinqingsang decoction for 2 weeks. The IL-4 and IL-5 levels in the PBMCs were determined using ELISA before and after the treatment, and the changes of the clinical symptoms were observed.
  
  
  RESULTS
  The levels of IL-4 and IL-5 in the PBMCs was 89.69∓13.82 ng/l and 12.17∓0.43 ng/ml before the treatment, which were significantly reduced to 72.18∓14.89 ng/l and 5.81∓0.31 ng/ml after the treatment (P<0.05). The symptoms including coughing, pharyngodynia, and pharyngo-itch were all improved obviously (P<0.05).
  
  
  CONCLUSIONS
  Ziyinqingsang decoction ameliorates the symptoms of CVA in the acute stage probably by decreasing the levels of IL-4 and IL-5 in the PBMCs of the children.
authors.affiliation: Department of Traditional Chinese Medicine, General Hospital of PLA, Beijing 100853, China. 301zhangyin@sina.com
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Feng
authors.forename: Ke
authors.initials: K
authors.lastname: Cao
mesh_terms: D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D002648:Child; D003371:Cough / Q000097:blood* / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015847:Interleukin-4 / Q000097:blood*; D015848:Interleukin-5 / Q000097:blood*; D007963:Leukocytes, Mononuclear; D008297:Male; D008517:Phytotherapy
chemical_list: D004365:Drugs, Chinese Herbal; D015848:Interleukin-5; D015847:Interleukin-4