title: Silicium dioxide nanoparticles as carriers for photoactivatable CO-releasing molecules (PhotoCORMs).
abstract: Silicium dioxide nanoparticles of about 20 nm diameter containing azido groups at the surface were prepared by emulsion copolymerization of trimethoxymethylsilane and (3-azidopropyl)triethoxysilane and studied by transmission electron microscopy (TEM). A photoactivatable CO-releasing molecule (PhotoCORM) based on [Mn(CO)(3)(tpm)](+) (tpm = tris(pyrazolyl)methane) containing an alkyne-functionalized tpm ligand was covalently linked to the silicium dioxide nanoparticles via the copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC "click" reaction). The surface functionalization of the particles with azido groups and manganese CORMs was analyzed by UV-vis, IR, (1)H and (13)C CP-MAS NMR spectroscopies as well as energy-dispersive X-ray spectroscopy (EDX). The myoglobin assay was used to demonstrate that the CORM-functionalized nanoparticles have photoinducible CO-release properties very similar to the free complex. In the future, such functionalized silicium dioxide nanoparticles might be utilized as delivery agents for CORMs in solid tumors.
authors.affiliation: Lehrstuhl für Anorganische Chemie I-Bioanorganische Chemie, Ruhr-Universität Bochum, Universitätsstrasse 150, D-44801 Bochum, Germany.
authors.forename: Gregor
authors.initials: G
authors.lastname: Dördelmann
authors.forename: Hendrik
authors.initials: H
authors.lastname: Pfeiffer
authors.forename: Alexander
authors.initials: A
authors.lastname: Birkner
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schatzschneider
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000818:Animals; D001386:Azides / Q000737:chemistry; D002248:Carbon Monoxide / Q000378:metabolism / Q000494:pharmacology; D002384:Catalysis / Q000187:drug effects / Q000528:radiation effects; D003300:Copper / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods; D006736:Horses; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese / Q000737:chemistry / Q000378:metabolism; D046529:Microscopy, Electron, Transmission; D009211:Myoglobin / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D055668:Photochemical Processes / Q000187:drug effects / Q000528:radiation effects; D058105:Polymerization; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry* / Q000378:metabolism*; D046590:Spectroscopy, Electron Energy-Loss; D014466:Ultraviolet Rays
chemical_list: D000475:Alkenes; D001386:Azides; D009211:Myoglobin; D012821:Silanes; D008345:Manganese; D012822:Silicon Dioxide; D003300:Copper; D002248:Carbon Monoxide; C522569:triethoxysilane