title: Streptothricin derivatives from Streptomyces sp. I08A 1776.
abstract: Five new streptothricin derivatives with a carbamoyl group substituted at C-12 (1-5) and three known analogues have been isolated from the culture broth of Streptomyces sp. I08A 1776 by ion exchange and hydrophilic interaction chromatographic techniques. Their structures were determined by spectroscopic and chemical methods. Compound 3 was a streptothricin derivative possessing a cis-streptolidine moiety. Its absolute configuration was defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Compound 5 and streptothricin E (6) displayed antibacterial and antifungal activity with MIC values in the range 1-64 μg/mL.
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Maoluo
authors.initials: M
authors.lastname: Gan
authors.forename: Xudong
authors.initials: X
authors.lastname: Zheng
authors.forename: Lishe
authors.initials: L
authors.lastname: Gan
authors.forename: Yan
authors.initials: Y
authors.lastname: Guan
authors.forename: Xueqin
authors.initials: X
authors.lastname: Hao
authors.forename: Yishuang
authors.initials: Y
authors.lastname: Liu
authors.forename: Shuyi
authors.initials: S
authors.lastname: Si
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Liyan
authors.initials: L
authors.lastname: Yu
authors.forename: Chunling
authors.initials: C
authors.lastname: Xiao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*; D013309:Streptothricins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013309:Streptothricins