title: Getting closer to the dirty little secret.
abstract: The molecular mechanism behind alum adjuvanticity is probably the oldest secret of immunology. In this issue of Immunity, Kuroda et al. (2011) and Kool et al. (2011) identify NLRP3 inflammasome-independent signaling to be crucial for the Th2 cell response induced by aluminum salts.
authors.affiliation: Institute of Innate Immunity, Biomedical Center, 1G008, University Hospitals, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Pelka
authors.forename: Eicke
authors.initials: E
authors.lastname: Latz