title: Association of TNF-α promoter-308 A/G polymorphism with susceptibility to systemic lupus erythematosus: a meta-analysis.
abstract: Published data on the association between tumor necrosis factor-alpha (TNF-α) promoter-308 A/G polymorphism and systemic lupus erythematosus (SLE) risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 28 studies including 2,992 cases and 4,326 controls (5,924 cases and 8,484 controls in A versus G comparison) were involved in this meta-analysis. Meta-analysis was performed for genotypes A/A (recessive effect), A/A+A/G (dominant effect), and A allele in fixed or random effects models. In addition, we also performed a "model-free" analysis by considering the G/G genotype as the reference and estimated the OR for the A/A versus G/G and A/G versus G/G genotype. Overall, an association of TNF-α promoter-308 A/G polymorphism with SLE was found (A versus G: OR = 1.686, 95% CI = 1.400-2.032, P < 0.001; A/A versus A/G+G/G: OR = 3.043, 95% CI = 2.185-4.238, P < 0.001; A/A+A/G versus G/G: OR = 1.822, 95% CI = 1.379-2.407, P < 0.001; A/A versus G/G: OR = 3.686, 95% CI = 2.628-5.172, P < 0.001; A/G versus G/G: OR = 1.691, 95% CI = 1.291-2.215, P < 0.001). However, stratification by ethnicity indicated that the risk A allele was not associated with SLE in Asian (A versus G: OR = 1.207, 95% CI = 0.856-1.702, P = 0.283) and African population (A versus G: OR = 1.225, 95% CI = 0.597-2.516, P = 0.580). In summary, this meta-analysis indicated that TNF-α promoter-308-A/G polymorphism is associated with susceptibility to SLE.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, People's Republic of China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Leng
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Wei-Zi
authors.initials: WZ
authors.lastname: Qin
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Chen
authors.forename: Zhen-Qiu
authors.initials: ZQ
authors.lastname: Zha
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Tao
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D014409:Tumor Necrosis Factor-alpha