title: Early plasmapheresis followed by high-dose γ-globulin treatment saved a severely Rho-incompatible pregnancy.
abstract: An alloimmunized pregnancy induces anemia in the fetus and can ultimately lead to fetal hydrops and intrauterine fetal death. A woman with a severe Rho-incompatible pregnancy had experienced frequent pregnancies with fetomaternal transfusion without receiving RhIg and had high anti-D antibody titers present from early pregnancy. We succeeded in long-term inhibition of antibody production using plasmapheresis followed by high-dose γ-globulin treatment in early pregnancy.
authors.affiliation: Department of Women's Health, National Center for Child Health and Development, Setagaya-ku, Tokyo 157-8535, Japan.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Isojima
authors.forename: Michi
authors.initials: M
authors.lastname: Hisano
authors.forename: Teruaki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sago
authors.forename: Atsuko
authors.initials: A
authors.lastname: Murashima
authors.forename: Koushi
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D000328:Adult; D004899:Erythroblastosis, Fetal / Q000276:immunology / Q000628:therapy; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood; D008297:Male; D010956:Plasmapheresis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000276:immunology / Q000628:therapy*; D012203:Rh Isoimmunization / Q000276:immunology / Q000628:therapy*; D012204:Rh-Hr Blood-Group System / Q000276:immunology; D018029:Rho(D) Immune Globulin / Q000008:administration & dosage
chemical_list: D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin