title: Mechanistic considerations in the development and use of azine, diazine and azole N-oxides in palladium-catalyzed direct arylation.
abstract: Azines, diazines or thiazole N-oxides are highly reactive substrates in palladium-catalyzed direct arylation reaction. For these reactions, the results are inconsistent with an SEAr reaction pathway and may best fit with a concerted metalation-deprotonation-like (CMD) mechanism.
authors.affiliation: Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON, Canada, KIN 6N5. keith.fagnou@uottawa.ca
authors.forename: Keith
authors.initials: K
authors.lastname: Fagnou
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis*; D006859:Hydrogen / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D010087:Oxides / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis; D026941:Sodium Channel Blockers / Q000138:chemical synthesis; D013379:Substrate Specificity
chemical_list: D006841:Hydrocarbons, Aromatic; D008670:Metals; D010087:Oxides; D047428:Protein Kinase Inhibitors; D026941:Sodium Channel Blockers; D010165:Palladium; D006859:Hydrogen