title: Relevance of timing for determination of posaconazole plasma concentrations.
abstract: For posaconazole, drug monitoring is suggested, but the relevance of timing for the determination of posaconazole concentration (PC) remains unclear. We investigated the variation of PC before and 4 and 8 h after the administration of 400 mg of posaconazole. Mean concentrations were 645, 678, and 616 ng/ml. The differences between trough and maximum concentrations were below 20% in 17 and below 30% in 20 of 25 patients. Hence, untimed posaconazole plasma concentrations give reliable information for most patients.
authors.affiliation: Department of Internal Medicine II, Division of Infectious Diseases, University of Wuerzburg Medical Center, Oberduerrbacher Str. 6, 97080 Wuerzburg, Germany. Heinz_W@klinik.uni-wuerzburg.de
authors.forename: Werner J
authors.initials: WJ
authors.lastname: Heinz
authors.forename: Janina
authors.initials: J
authors.lastname: Zirkel
authors.forename: Anna
authors.initials: A
authors.lastname: Kuhn
authors.forename: Diana
authors.initials: D
authors.lastname: Schirmer
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lenker
authors.forename: Daniela
authors.initials: D
authors.lastname: Keller
authors.forename: Hartwig
authors.initials: H
authors.lastname: Klinker
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole