title: New genes involved in hepatic steatosis.
abstract: OBJECTIVE
  To summarize currently available information about the mechanisms involved in liver fat accumulation.
  
  
  RESULTS
  The contribution of functional genomics approaches, such as those represented by high-throughput analysis and genetically modified mice, may envision a complex network involving fatty acid, triglyceride and phospholipid metabolisms and lipid droplet dynamics. Likewise, it may pose an exquisite regulation exerted through insulin, glucocorticoids, thyroid hormones, transcription factors and microRNAs, orchestrated with sexual differences and able to respond to environmental factors such as nutritional or viral influences among others.
  
  
  CONCLUSIONS
  The information gathered will facilitate further research to complete gaps of interacting pieces among regulators and new contributing agents emerging from high-throughput analyses. With this new paradigm, new biomarkers able to discriminate the progression of hepatic steatosis into human steatohepatitis will eventually emerge, and hopefully new therapeutic approaches will be developed.
authors.affiliation: Departamento de Farmacología y Fisiología, Facultad de Ciencias de Salud y del Deporte, Instituto de Investigación Sanitaria de Aragón, Universidad de Zaragoza, Zaragoza, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Lou-Bonafonte
authors.forename: Carmen
authors.initials: C
authors.lastname: Arnal
authors.forename: Jesús
authors.initials: J
authors.lastname: Osada
mesh_terms: D000818:Animals; D005234:Fatty Liver / Q000235:genetics* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D053858:Metabolic Networks and Pathways / Q000235:genetics