title: The electrical conductivity of in vivo human uterine fibroids.
abstract: The purpose of this study was to determine the value of electrical conductivity that can be used for numerical modelling in vivo radiofrequency ablation (RFA) treatments of human uterine fibroids. No experimental electrical conductivity data have previously been reported for human uterine fibroids. In this study electrical data (voltage) from selected in vivo clinical procedures on human uterine fibroids were used to numerically model the treatments. Measured versus calculated power dissipation profiles were compared to determine uterine fibroid electrical conductivity. Numerical simulations were conducted utilising a wide range of values for tissue thermal conductivity, heat capacity and blood perfusion coefficient. The simulations demonstrated that power dissipation was insensitive to the exact values of these parameters for the simulated geometry, treatment duration, and power level. Consequently, it was possible to determine tissue electrical conductivity without precise knowledge of the values for these parameters. Results of this study showed that an electrical conductivity for uterine fibroids of 0.305 S/m at 37°C and a temperature coefficient of 0.2%/°C can be used for modelling Radio Frequency Ablation of human uterine fibroids at a frequency of 460 kHz for temperatures from 37°C to 100°C.
authors.affiliation: Halt Medical, Inc., Brentwood, CA, USA.
authors.forename: Russ
authors.initials: R
authors.lastname: DeLonzor
authors.forename: Richard K
authors.initials: RK
authors.lastname: Spero
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Williams
mesh_terms: D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods; D003198:Computer Simulation; D004553:Electric Conductivity; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D008954:Models, Biological; D013696:Temperature; D014594:Uterine Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery