title: Carcinoma infection and immune systems of Ehrlich ascites carcinoma-bearing mice treated with structurally similar sulfonium compounds.
abstract: The effects of intraperitoneal administration of dimethylsulfonioacetate (DMSA), dimethlsulfoniopropionate (DMSP), and methylmethionine (MeMet) solutions (10 mM each) on the body weights and the hematological parameters (red and white blood cells) of Ehrlich ascites carcinoma (EAC)-bearing mice were examined for up to 10 d. Body weights significantly increased in the EAC-bearing mice treated with and without MeMet in contrast to those with DMSA and DMSP. This increase was attributed to the increased amounts of ascitic fluid. EAC-bearing mice with and without MeMet both showed abnormal values of hematological parameters, while those with DMSA and DMSP exhibited almost normal levels on the 10th day.
authors.affiliation: Department of Nutrition, Faculty of Nutrition, Koshien University, Japan. fantasista999@gmail.com
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakajima
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nakajima
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D007107:Immune System / Q000187:drug effects*; D008297:Male; D051379:Mice; D013452:Sulfonium Compounds / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D013452:Sulfonium Compounds