title: The influence of Nifadin, Niprisan and Niprd/92/001/1-1 (AM-1) on the pharmacokinetics of metronidazole in rats.
abstract: The single oral dose pharmacokinetics of metronidazole was studied alone and after co-administration with phytomedicines, Nifadin, Niprisan and Niprd/92/001/1-1 (AM-1), in rats. Plasma metronidazole concentrations were measured using high-performance liquid chromatography method developed earlier in our laboratory. The data were fitted into a WinNonlin standard non-compartmental programme. The co-administration of the herbal medicines with metronidazole produced an increase in the serum concentration of metronidazole at each sampling time. The highest increase of 184% occurring at the time of peak concentration (1 h) was obtained with AM-1, followed by 145% with Niprisan, the least was 131% with Nifadin. Significant increase was also observed in some other parameters, such as area under the serum concentration-time curve (AUC0-24) and maximum serum concentration (Cmax), while the apparent volume of distribution (Vd) and plasma clearance (C1) reduced significantly (P < 0.05). It was concluded that the gastric presence of the herbal medicines impaired the absorption and elimination Niadin alone) of metronidazole in rats significantly (P < 0.05).
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, A.B.U., Zaria, Nigeria. mojitaibat@yahoo.com
authors.forename: M T
authors.initials: MT
authors.lastname: Bakare-Odunola
authors.forename: K B
authors.initials: KB
authors.lastname: Mustapha
authors.forename: M
authors.initials: M
authors.lastname: Garba
authors.forename: O O
authors.initials: OO
authors.lastname: Obodozie
authors.forename: I S
authors.initials: IS
authors.lastname: Enemali
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D000962:Antimalarials / Q000494:pharmacology; D041743:Herb-Drug Interactions; D008297:Male; D008795:Metronidazole / Q000493:pharmacokinetics*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000890:Anti-Infective Agents; D000962:Antimalarials; C557335:NIPRD-AM1; C558147:Nifadin; C445122:Niprisan; D010936:Plant Extracts; D008795:Metronidazole