title: Microarray analysis in gynaecology and its findings: a systematic review.
abstract: Microarray technology is a promising method for investigating gynaecological benign pathology. This systematic review examined various parameters of the design of these studies, the methods used and the gene outcome in these diseases. Electronic searches were performed in Medline (up to April 2009). An overall representation of important genes for each disease detected was performed. The results showed genes were up-regulated or down-regulated. However, studies suffer from several flaws in their design, the sample size employed and the reporting method. In conclusion, a significant amount of work has been performed on benign gynaecological diseases using microarray technology. New trial designs need to be employed that incorporate microarray reporting standards. New research directions should evolve based on these results.
authors.affiliation: Department of Physiology, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Verginadis
authors.forename: I P
authors.initials: IP
authors.lastname: Kosmas
authors.forename: Y
authors.initials: Y
authors.lastname: Simos
authors.forename: A
authors.initials: A
authors.lastname: Velalopoulou
authors.forename: I
authors.initials: I
authors.lastname: Korkontzelos
authors.forename: A
authors.initials: A
authors.lastname: Anogeianaki
authors.forename: K
authors.initials: K
authors.lastname: Charalampopoulos
mesh_terms: D000818:Animals; D005260:Female; D052776:Female Urogenital Diseases / Q000235:genetics*; D020869:Gene Expression Profiling; D006801:Humans; D046228:Microarray Analysis; D013673:Technology Assessment, Biomedical