title: Developing a genetically informative measure of alcohol consumption using past-12-month indices.
abstract: OBJECTIVE
  The goal of this study was to develop a factor score derived from measures of past-12-month alcohol consumption.
  
  
  METHODS
  Data were drawn from two studies-the Adult and Family Development Project (N = 734) and the Missouri Adolescent Female Twin Study (N = 3,787). Data on four indices of alcohol consumption (quantity, frequency, frequency of drinking to intoxication, and frequency of five or more drinks/day) were factor analyzed, and differences in factor loadings across gender, race/ethnicity, and study were tested. Correlations between these factors were computed across three assessments and between parent and offspring self-reports. Finally, using the classical twin design, variance in the past-12-month alcohol consumption factor was decomposed into additive genetic (A), shared environmental (C), and nonshared environmental (E) influences, and the extent to which these factors overlap with those influencing lifetime heaviest drinking were examined.
  
  
  RESULTS
  Factor loadings across all groups were high (.69-.95), with some evidence for differing factor loadings across gender, race/ethnicity, and study. The across-wave correlations for the factor ranged from .22 to .62. The within-wave correlation between parental and offspring drinking was .25, suggesting the importance of familial influences, which genetic analyses attributed to both additive genetic (31%) and shared environmental (17%) factors. The overlap between genetic influences on past-12-month and lifetime heaviest drinking was 0.97.
  
  
  CONCLUSIONS
  A factor score derived from past-12-month drinking measures is heritable and is largely influenced by those genetic factors that influence heaviest drinking, at least in young adults. It also shows moderate across-wave stability. This will allow for large- and small-scale genomic studies to use past-12-month drinking measures in data analysis of similar cohorts.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, CB 8134, St. Louis, Missouri 63110, USA. arpana@wustl.edu
authors.forename: Arpana
authors.initials: A
authors.lastname: Agrawal
authors.forename: Michael T
authors.initials: MT
authors.lastname: Lynskey
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Heath
authors.forename: Laurie
authors.initials: L
authors.lastname: Chassin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000235:genetics; D000435:Alcoholic Intoxication / Q000453:epidemiology*; D005163:Factor Analysis, Statistical; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010290:Parents; D044469:Racial Groups / Q000706:statistics & numerical data; D012307:Risk Factors; D012737:Sex Factors; D014427:Twins; D055815:Young Adult