title: Preferential emergence of reduced vancomycin susceptibility in health care-associated methicillin-resistant Staphylococcus aureus isolates during continuous-infusion vancomycin therapy in an in vitro dynamic model.
abstract: Bacterial killing and the development of reduced vancomycin susceptibility during continuous-infusion vancomycin (CIV) therapy were dependent on the area under the concentration-time curve over 24 h divided by the MIC (ƒAUC(24)/MIC), with values of ≥ 240 (equivalent total serum AUC(24)/MICs of ≥ 480) being bactericidal and suppressing emerging resistance in methicillin-resistant Staphylococcus aureus (MRSA). Also, vancomycin therapy was less likely to be bactericidal and 4.4 times more likely to lead to reduced vancomycin susceptibility in health care-associated MRSA than in community-associated MRSA.
authors.affiliation: Faculty of Pharmacy, Department of Medicine, Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada. s_zelenitsky@umanitoba.ca
authors.forename: Sheryl
authors.initials: S
authors.lastname: Zelenitsky
authors.forename: Noha
authors.initials: N
authors.lastname: Alkurdi
authors.forename: Zhanni
authors.initials: Z
authors.lastname: Weber
authors.forename: Robert
authors.initials: R
authors.lastname: Ariano
authors.forename: George
authors.initials: G
authors.lastname: Zhanel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin