title: [Synthesis and hypoglycemic activity of bis(L-malato)oxovanadium(IV)].
abstract: In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV) was prepared and its potential as a novel hypoglycemic agent was studied in the streptozotocin-diabetic rats. We show that the oral administration of bis(L-malato)oxovanadium(IV) with drink water significantly reduced glucose concentration in blood and urine, as well as the level of glycated proteins in the streptozotocin-diabetic rats.
authors.forename: V K
authors.initials: VK
authors.lastname: Gorodetskiĭ
authors.forename: A I
authors.initials: AI
authors.lastname: Tochilkin
authors.forename: N F
authors.initials: NF
authors.lastname: Beliaeva
authors.forename: I R
authors.initials: IR
authors.lastname: Kovel'man
authors.forename: B F
authors.initials: BF
authors.lastname: Korovkin
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008293:Malates / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014638:Vanadates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008293:Malates; D014638:Vanadates; C030298:malic acid