title: GEIRA: gene-environment and gene-gene interaction research application.
abstract: The GEIRA (Gene-Environment and Gene-Gene Interaction Research Application) algorithm and subsequent program is dedicated to genome-wide gene-environment and gene-gene interaction analysis. It implements concepts of both additive and multiplicative interaction as well as calculations based on dominant, recessive and co-dominant genetic models, respectively. Estimates of interactions are incorporated in a single table to make the output easily read. The algorithm is coded in both SAS and R. GEIRA is freely available to non-commercial users at http://www.epinet.se. Additional information, including user's manual and example datasets is available online at http://www.epinet.se.
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet, SE-171 77, Box 210, Stockholm, Sweden. Bo.Ding@ki.se
authors.forename: Bo
authors.initials: B
authors.lastname: Ding
authors.forename: Henrik
authors.initials: H
authors.lastname: Källberg
authors.forename: Lars
authors.initials: L
authors.lastname: Klareskog
authors.forename: Leonid
authors.initials: L
authors.lastname: Padyukov
authors.forename: Lars
authors.initials: L
authors.lastname: Alfredsson
mesh_terms: D000465:Algorithms; D004843:Epistasis, Genetic / Q000502:physiology*; D059647:Gene-Environment Interaction; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D020641:Polymorphism, Single Nucleotide