title: The ECRG1 290Arg/Gln polymorphism is related to risk of esophageal squamous cell carcinoma in Kashmir.
abstract: ECRG1 (esophageal cancer related gene 1) is a novel candidate member of the tumor suppressor gene family previously found to be down regulated in human esophageal cancer (ESCC). So far no evidence regarding the role of the ECRG1 gene in this cancer has been reported from the Kashmir valley, located on the border of the high risk 'esophageal cancer belt'. A case control study was therefore carried out with genomic DNA from 165 newly diagnosed ESCC patients (cases) and 200 control subjects. DNA was analyzed for ECRG1 polymorphisms by RFLP PCR, gel electrophoresis and direct sequencing. A statistically significantly increased risk of ESCC was found to be associated with the ECRG1 Arg/Gln and Gln/Gln genotype occurrence compared to the Arg/Arg genotype (odds ratio (OR) 1.698, 95% confidence interval (CI) 1.112-2.593); P= 0.0138) was observed. Statistically significant results were also obtained between the ECRG1 polymorphism and histophathological grade, smoking, dysphagia, low fruit/vegetable intake and salt tea consumption.
authors.affiliation: Department of Biochemistry, University of Kashmir, Hazratbal, India.
authors.forename: Sabha
authors.initials: S
authors.lastname: Rasool
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Ganai
authors.forename: Showkat Ahmad
authors.initials: SA
authors.lastname: Kadla
authors.forename: Abdul Gani
authors.initials: AG
authors.lastname: Ahanger
authors.forename: Falak
authors.initials: F
authors.lastname: Qazi
authors.forename: Tanzeela
authors.initials: T
authors.lastname: Khan
authors.forename: Vamiq
authors.initials: V
authors.lastname: Rasool
authors.forename: Akbar
authors.initials: A
authors.lastname: Masood
mesh_terms: D044466:Asian People / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D016001:Confidence Intervals; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D057057:Serine Proteases / Q000235:genetics*
chemical_list: D008565:Membrane Proteins; C446704:TMPRSS11A protein, human; D057057:Serine Proteases