title: Objective tinnitus from palatal myoclonus. Use of botulinum toxin: a case report.
abstract: Objective tinnitus can have many different etiologies, palatal myoclonus being one of the less frequent. This type of tinnitus is generated by involuntary rhythmic contraction of the soft palate, which generates an audible click for the patient and for the explorer. Botulinum toxin achieves temporary muscle paralysis through presynaptic inhibition of the acetylcholine level at the neuromuscular union. We present a patient with long-term objective tinnitus, along with this patient's response to botulinum toxin injection.
authors.affiliation: Servicio Otorrinolaringología, Hospital Clínico Universitario, Valencia, España. noeconill@hotmail.es
authors.forename: Noemi
authors.initials: N
authors.lastname: Conill Tobías
authors.forename: Carlos
authors.initials: C
authors.lastname: de Paula Vernetta
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: García Callejo
authors.forename: Jaime
authors.initials: J
authors.lastname: Marco Algarra
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007267:Injections; D009207:Myoclonus / Q000150:complications*; D010156:Palatal Muscles / Q000187:drug effects / Q000503:physiopathology*; D010160:Palate, Soft / Q000503:physiopathology*; D012008:Recurrence; D014012:Tinnitus / Q000188:drug therapy* / Q000209:etiology
chemical_list: D018680:Cholinergic Antagonists; D019274:Botulinum Toxins, Type A; D000109:Acetylcholine