title: MicroRNA-451 in chronic myeloid leukemia: miR-451-BCR-ABL regulatory loop?
abstract: Chronic myeloid leukemia (CML) is caused by constituve activity of BCR-ABL tyrosine kinase. Despite of high efficiency of imatinib, selective BCR-ABL inhibitor, about 30% of patients develop resistance. Novel markers and targets for therapy are thus necessary. MicroRNAs are small intereference RNAs whose role in physiological and malignant hematopoiesis has been shown. This study is focused on miR-451 in CML. Following our observation of miR-451 downregulation in CML, we further show its relation to BCR-ABL activity. Our data together with current literature indicate a more complex relationship of miR-451 and BCR-ABL in CML.
authors.affiliation: Department of Molecular Genetics, Institute of Hematology and Blood Transfusion, Prague, Czech Republic. tereza.lopotova@uhkt.cz
authors.forename: Tereza
authors.initials: T
authors.lastname: Lopotová
authors.forename: Markéta
authors.initials: M
authors.lastname: Záčková
authors.forename: Hana
authors.initials: H
authors.lastname: Klamová
authors.forename: Jana
authors.initials: J
authors.lastname: Moravcová
mesh_terms: D016044:Fusion Proteins, bcr-abl / Q000037:antagonists & inhibitors*; D016313:Genes, abl / Q000502:physiology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*
chemical_list: C531201:MIRN451 microRNA, human; D035683:MicroRNAs; D016044:Fusion Proteins, bcr-abl