title: Small molecule microarrays: the first decade and beyond.
abstract: The turn of the century witnessed the development of small molecule, protein, cell and tissue microarrays, heralding a new era of discovery-driven research using a host of different chemical libraries, biomolecules and tissue types. This highlight takes stock of this first decade of small molecule microarrays (SMMs) and describes how the technology has matured into a robust screening platform. We also highlight the many interesting and unique applications appearing using small molecule microarrays, in order to project forward to possible areas in which SMMs could contribute further to over the next five to ten years.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive34, Singapore 117543. chmyaosq@nus.edu.sg.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive34, Singapore 117543. chmyaosq@nus.edu.sg.
authors.forename: Jingyan
authors.initials: J
authors.lastname: Ge
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive34, Singapore 117543. chmyaosq@nus.edu.sg and Department of Biological Sciences, National University of Singapore, Singapore 117543 and Defence Medical and Environmental Research Institute, DSO National Laboratories 27 Medical Drive, Singapore 117510. mahesh@dso.org.sg.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Uttamchandani
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive34, Singapore 117543. chmyaosq@nus.edu.sg and Department of Biological Sciences, National University of Singapore, Singapore 117543 and NUS MedChem Program of the Office of the Life Sciences, National University of Singapore, Singapore 117543.
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D008024:Ligands; D040081:Protein Array Analysis / Q000379:methods*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry; D054852:Small Molecule Libraries / Q000737:chemistry*
chemical_list: D008024:Ligands; D011506:Proteins; D054852:Small Molecule Libraries