title: A metabonomic analysis on health effects of drinking water on male mice (Mus musculus).
abstract: Health effects of drinking water on the male mice (Mus musculus) were investigated by metabonomics after exposure to the Taihu drinking water for 90 days. Metabonomics data combined with the results of conventional serum biochemistry tests and hepatic histopathology showed that the drinking water induced adverse health effects on the male mice. It was found that the serum levels of pyruvate, glutamine, arginine, lysine, N-acetyl glycoproteins, choline and citrate were significantly decreased in the treatment group. These results indicated that Taihu drinking water may induce damages on mice liver via perturbations of energy metabolism, amino acid metabolism and apoptosis. These observations yielded novel insights regarding the environmental health risk of Taihu drinking water.
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing, Jiangsu 210046, China. zhangyannju@gmail.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.forename: Zong-Yao
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Shu-Pei
authors.initials: SP
authors.lastname: Cheng
mesh_terms: D000818:Animals; D002681:China; D004326:Drinking; D004782:Environmental Health / Q000379:methods*; D008107:Liver Diseases / Q000209:etiology*; D008297:Male; D055432:Metabolomics / Q000379:methods*; D051379:Mice; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000633:toxicity*; D014881:Water Supply / Q000592:standards*
chemical_list: D014874:Water Pollutants, Chemical