title: Maternal vitamin D and fetal growth in early-onset severe preeclampsia.
abstract: OBJECTIVE
  Recently, vitamin D deficiency has been associated with increased risks for preeclampsia and diagnosis of early-onset, severe preeclampsia (EOSPE). The purpose of this investigation was to examine the association between vitamin D levels and small-for-gestational age (SGA) in patients with EOSPE.
  
  
  METHODS
  Patients with EOSPE were recruited, and demographics, outcomes, and plasma were collected. We assessed 25-hydroxyvitamin D (25[OH]D) by radioimmunoassay and reported our findings in nanograms per milliliter. Results were analyzed by Mann-Whitney U test and Spearman correlation and were reported as median (Q1-Q3).
  
  
  RESULTS
  In patients with EOSPE (n = 56), 25(OH)D was lower in patients with SGA (16.8 ng/mL; range, 8.9-23 ng/mL) vs normal fetal growth (25.3 ng/mL; range, 16-33 ng/mL; P = .02). 25(OH)D was correlated significantly with percentile growth at delivery (ρ = 0.31; P = .02).
  
  
  CONCLUSIONS
  Vitamin D is lower among patients with SGA in EOSPE than those without growth retardation. We suspect that vitamin D may impact fetal growth through placental mechanisms.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Robinson
authors.forename: Carol L
authors.initials: CL
authors.lastname: Wagner
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Hollis
authors.forename: John E
authors.initials: JE
authors.lastname: Baatz
authors.forename: Donna D
authors.initials: DD
authors.lastname: Johnson
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D047109:Fetal Development; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012720:Severity of Illness Index; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D