title: [Glutamate decarboxylase and GABA-aminotransferase activity in brain mitochondria under conditions of ethanol exposure in postnatal ontogenesis].
abstract: The activity of the enzymes of GABA- GDK and GABA-T metabolism in the brain mitochondria in 6 periods of postnatal development under the conditions of high dose of ethanol was studied. It has been revealed that after the impact of high dose of ethanol (3.5 g/kg of 25% solution, intraperitoneally) the enzymes' activities in initial mitochondrial fractions of cerebral cortex, cerebellum, hypothalamus and brain stem increases. The activity of GABA-T in 10- and 21-days animals significantly decreases, while in other periods on the contrary it increases.
authors.forename: S A
authors.initials: SA
authors.lastname: Mikailova
authors.forename: A N
authors.initials: AN
authors.lastname: Faradzhev
authors.forename: M I
authors.initials: MI
authors.lastname: Safarov
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D051381:Rats
chemical_list: D000431:Ethanol; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase