title: Bone quantitative ultrasound at hand phalanges of women following breast cancer surgery.
abstract: Breast cancer surgery and its adjunctive therapy follow in lymphedema, decreased limb mobility and bone deterioration. The aim was to establish relation of postsurgical limb lymphedema with bone properties assessed by quantitative ultrasound (QUS) measurement of hand phalanges in postmenopausal women after breast cancer surgery. In all, 63 women aged 62.81 ± 8.83 years, after breast cancer surgery were compared with control group of 418 age-matched women. Their skeletal status was assessed by QUS measurements at proximal phalanges using DBM Sonic 1200. There were no statistically significant differences in QUS measurements (Ad-SoS) between groups of operated subjects and the controls, between limbs (operated vs. nonoperated side, with and without lymphedema), and regarding method of surgery. Ad-SoS was greater in estrogen-treated patients than in nontreated ones at the side with no breast surgery (1994.11 ± 67.83 vs. 1943.27 ± 58.34; P = 0.046). Ad-SoS was lower in patients with adjunctive antiestrogen therapy than without this therapy at the side of surgery (1937.35 ± 54.71 vs. 1966.78 ± 59.18; P = 0.0449), and nonbreast surgery side (1934.55 ± 52.06 vs. 1973.31 ± 57.17; P = 0.0066). Breast cancer surgery followed by concomitant therapies does not influence significantly QUS at hand phalanges. This was proven regarding method of surgery, side of surgery, and lymphedema. Additional hormonal treatment can influence phalangeal QUS in breast cancer survivors.
authors.affiliation: Department of Endocrinology, Diabetology and Isotope Therapy, Medical University, Wrocław, Poland. bolan@endo.am.wroc.pl
authors.forename: Marek
authors.initials: M
authors.lastname: Bolanowski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Chwałczyńska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Pluskiewicz
mesh_terms: D000368:Aged; D001837:Body Weights and Measures / Q000379:methods; D015519:Bone Density / Q000502:physiology; D001943:Breast Neoplasms / Q000534:rehabilitation* / Q000601:surgery*; D002277:Carcinoma / Q000534:rehabilitation* / Q000601:surgery*; D016022:Case-Control Studies; D020847:Estrogen Receptor Modulators / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D050278:Finger Phalanges / Q000000981:diagnostic imaging* / Q000187:drug effects; D005500:Follow-Up Studies; D050276:Hand Bones / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology; D011184:Postoperative Period; D014463:Ultrasonography
chemical_list: D020847:Estrogen Receptor Modulators