title: Gag-specific CD4+ T-cell responses are associated with virological control of paediatric HIV-1 infection.
abstract: HIV-specific Elispot responses were investigated in 57 antiretroviral therapy-naive children, of median age 9.9 years. CD8(+) T-cell responses were detected in 96% children; Nef was the immunodominant protein. Responses broadened over time, but there was no association between magnitude, breadth or specificity of response and viraemia. Gag-specific CD4(+) T-cell responses, detectable in 26% children, correlated inversely with viraemia (R = -0.43, P < 0.001), suggesting that preservation of this cell population may be an important goal of therapeutic/vaccine strategies.
authors.affiliation: Department of Paediatrics, University of Oxford, UK. andy.prendergast@gmail.com
authors.forename: Andrew
authors.initials: A
authors.lastname: Prendergast
authors.forename: Hannah
authors.initials: H
authors.lastname: Goodliffe
authors.forename: Margaret
authors.initials: M
authors.lastname: Clapson
authors.forename: Robyn
authors.initials: R
authors.lastname: Cross
authors.forename: Gareth
authors.initials: G
authors.lastname: Tudor-Williams
authors.forename: Anna
authors.initials: A
authors.lastname: Riddell
authors.forename: Justin
authors.initials: J
authors.lastname: Daniels
authors.forename: Amanda
authors.initials: A
authors.lastname: Williams
authors.forename: Philip
authors.initials: P
authors.lastname: Goulder
mesh_terms: D000293:Adolescent; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015750:Genes, gag / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D019562:Viral Load