title: ATG16L1 gene polymorphisms are associated with palmoplantar pustulosis.
abstract: Genes in autophagy pathway play an important role in innate and adaptive immunity. The aim of the study was to assess the impact of ATG16L1 gene on susceptibility of palmoplantar pustulosis. Four single nucleotide polymorphisms (SNPs) within the ATG16L1 region (rs2241880, rs2241879, rs7587633, and rs13005285) were genotyped in 241 control subjects and 38 palmoplantar pustulosis (PPP) patients of Estonian descent. The data analysis revealed a significantly higher frequency distribution of the rs2241880 G (odds ratio [OR] = 1.88, p = 0.0073) and rs2241879 A (OR = 1.87, p = 0.0079) allele in the PPP group when compared with the control group. The frequency distribution of the GACG haplotype was significantly higher (OR = 1.82, p = 0.016) in the PPP group when compared with the control group. The current study provides evidence of an association of the ATG16L1 gene in susceptibility to palmoplantar pustulosis, and supports the notion that the ATG16L1 gene as a member of the autophagy pathway most likely plays an important role in immune response.
authors.affiliation: Department of Physiology, University of Tartu, Tartu, Estonia. drkmb@email.com
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Douroudis
authors.forename: Külli
authors.initials: K
authors.lastname: Kingo
authors.forename: Tanel
authors.initials: T
authors.lastname: Traks
authors.forename: Ranno
authors.initials: R
authors.lastname: Rätsep
authors.forename: Helgi
authors.initials: H
authors.lastname: Silm
authors.forename: Eero
authors.initials: E
authors.lastname: Vasar
authors.forename: Sulev
authors.initials: S
authors.lastname: Kõks
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011565:Psoriasis / Q000235:genetics*
chemical_list: C518959:ATG16L1 protein, human; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins