title: [Association of peripheral blood hypoxia-inducible factor-1α with metastasis of colorectal cancer].
abstract: OBJECTIVE
  To explore the relationship between hypoxia-inducible factor-1α (HIF-1α) mRNA levels in the peripheral blood and the metastasis of colorectal cancer.
  
  
  METHODS
  HIF-1α mRNA in the peripheral blood was detected by RT-PCR in 40 patients with colorectal cancer and 20 healthy subjects.
  
  
  RESULTS
  Seventeen patients with colorectal cancer showed positivity for HIF-1α mRNA, showing a significantly higher positivity rate (42.5%) than the healthy subjects (P<0.05). The expression of HIF-1α mRNA is closely related to the staging of colorectal cancer (CRC).
  
  
  CONCLUSIONS
  HIF-1α mRNA may serve as a potential marker in the detection of metastasis of colorectal cancer.
authors.affiliation: Department of Emergency Medicine, Nanfang Hospital Southern Medical University, Guangzhou 510515, China.
authors.forename: Chun-Qiu
authors.initials: CQ
authors.lastname: Pan
authors.forename: Shu-Ling
authors.initials: SL
authors.lastname: Han
authors.forename: Bi-Xiang
authors.initials: BX
authors.lastname: Yu
authors.forename: Can-Hui
authors.initials: CH
authors.lastname: Zeng
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D012333:RNA, Messenger / Q000235:genetics
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D012333:RNA, Messenger