title: New antiplasmodial indole alkaloids from Hunteria zeylanica.
abstract: Two new indole alkaloids, bisnicalaterine D (1), consisting of an eburnane and a corynanthe type of skeletons, and nicalaterine A (2) were isolated from the bark of Hunteria zeylanica. Their structures were elucidated by various spectroscopic data such as NMR and CD spectra. A series of bisnicalaterines and nicalaterine A showed potent antiplasmodial activity against Plasmodium falciparum 3D7.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Alfarius E
authors.initials: AE
authors.lastname: Nugroho
authors.forename: Masatomo
authors.initials: M
authors.lastname: Sugai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hosoya
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Wiwied
authors.initials: W
authors.lastname: Ekasari
authors.forename: Aty
authors.initials: A
authors.lastname: Widyawaruyanti
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D002942:Circular Dichroism; D018922:HL-60 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D026121:Indole Alkaloids