title: Recent progress in SERS biosensing.
abstract: This perspective gives an overview of recent developments in surface-enhanced Raman scattering (SERS) for biosensing. We focus this review on SERS papers published in the last 10 years and to specific applications of detecting biological analytes. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids, lipids, peptides, and proteins, as well as for in vivo and cellular sensing. Current SERS substrate technologies along with a series of advancements in surface chemistry, sample preparation, intrinsic/extrinsic signal transduction schemes, and tip-enhanced Raman spectroscopy are discussed. The progress covered herein shows great promise for widespread adoption of SERS biosensing.
authors.affiliation: Department of Chemistry, University of Minnesota, Twin Cities, USA.
authors.forename: Kyle C
authors.initials: KC
authors.lastname: Bantz
authors.forename: Audrey F
authors.initials: AF
authors.lastname: Meyer
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Wittenberg
authors.forename: Hyungsoon
authors.initials: H
authors.lastname: Im
authors.forename: Ozge
authors.initials: O
authors.lastname: Kurtuluş
authors.forename: Si Hoon
authors.initials: SH
authors.lastname: Lee
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Lindquist
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Oh
authors.forename: Christy L
authors.initials: CL
authors.lastname: Haynes
mesh_terms: D000906:Antibodies / Q000737:chemistry / Q000276:immunology; D052157:Aptamers, Nucleotide / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry; D004798:Enzymes / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D000906:Antibodies; D052157:Aptamers, Nucleotide; D004798:Enzymes; D010455:Peptides; D011506:Proteins; D004247:DNA