title: Mass spectrometry imaging for drugs and metabolites.
abstract: Mass spectrometric imaging (MSI) is a powerful analytical technique that provides two- and three-dimensional spatial maps of multiple compounds in a single experiment. This technique has been routinely applied to protein, peptide, and lipid molecules with much less research reporting small molecule distributions, especially pharmaceutical drugs. This review's main focus is to provide readers with an up-to-date description of the substrates and compounds that have been analyzed for drug and metabolite composition using MSI technology. Additionally, ionization techniques, sample preparation, and instrumentation developments are discussed.
authors.affiliation: Department of Chemistry and School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705–2222, USA.
authors.forename: Tyler
authors.initials: T
authors.lastname: Greer
authors.forename: Robert
authors.initials: R
authors.lastname: Sturm
authors.forename: Lingjun
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation* / Q000379:methods*; D004364:Pharmaceutical Preparations; D010599:Pharmacokinetics
chemical_list: D004364:Pharmaceutical Preparations