title: Analytical strategies for assessment of human metabolites in preclinical safety testing.
abstract: Strategies for the detection, identification, and quantification of in vivo drug metabolites from non-radiolabeled studies are reviewed with an emphasis on the utilization of accurate-mass-based data mining tools. New approaches to the determination of coverage of human drug metabolites in preclinical species without using radiolabeled drugs or synthetic standards are also discussed.
authors.affiliation: Merck Research Laboratories, Kenilworth, NJ 07033, USA.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Ma
authors.forename: Swapan K
authors.initials: SK
authors.lastname: Chowdhury
mesh_terms: D001711:Biotransformation; D002853:Chromatography, Liquid; D006801:Humans; D013058:Mass Spectrometry; D018675:Toxicity Tests