title: Motor callosal disconnection in early relapsing-remitting multiple sclerosis.
abstract: In relapsing-remitting multiple sclerosis (RRMS) the corpus callosum (CC) is often and early affected by macroscopic lesions when investigated by conventional MRI. We sought to determine to which extent microstructural and effective disconnection of the CC are already present in RRMS patients at the earliest stages of the disease prior to evidence of macroscopic CC lesion. We compared 16 very early RRMS patients (median expanded disability status scale (EDSS), 1.5; range, 0-2.0) to an age-matched group of healthy controls and focused analysis to the motor CC, i.e. that part of the CC relaying interhemispheric motor information. A combined functional magnetic resonance imaging/diffusion tensor imaging fiber-tracking procedure was applied to identify the callosal motor fibers (CMFs) connecting the hand areas of the primary motor cortices of the two hemispheres. Fractional anisotropy (FA) within the motor CC (FA-CC) assessed the CMF microstructural integrity. Bifocal paired transcranial magnetic stimulation (TMS) tested short-interval interhemispheric inhibition (S-IHI), an established measure of CMF effective connectivity. FA-CC and S-IHI were significantly reduced in early RRMS compared to healthy controls. Furthermore, a significant linear correlation between microstructure (FA-CC) and function (S-IHI) in the controls was broken down in the patients. These abnormalities were obtained in the absence of macroscopic CMF lesion in conventional MRI, and whilst motor hand/arm function in the nine-hole-peg test and corticospinal conduction time were normal. Findings suggest that reductions in FA and S-IHI may serve as surrogate markers of motor callosal disconnection at the earliest stages of RRMS prior to development of macroscopic lesion.
authors.affiliation: Department of Neurology, Goethe-University Frankfurt, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Wahl
authors.forename: Annemarie
authors.initials: A
authors.lastname: Hübers
authors.forename: Birgit
authors.initials: B
authors.lastname: Lauterbach-Soon
authors.forename: Elke
authors.initials: E
authors.lastname: Hattingen
authors.forename: Patrick
authors.initials: P
authors.lastname: Jung
authors.forename: Leonardo G
authors.initials: LG
authors.lastname: Cohen
authors.forename: Ulf
authors.initials: U
authors.lastname: Ziemann
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002648:Child; D003337:Corpus Callosum / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007223:Infant; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000473:pathology*; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult