title: Peripheral antioxidant markers in mild cognitive impairment and its progression to dementia.
abstract: Mild cognitive impairment (MCI) is recognized as a prodromal phase of dementing disorders, and it has been suggested that oxidative stress may play a role in the pathogenesis of Alzheimer's disease (AD), and in predicting progression of MCI to AD. In the present article, on the basis of an increasing body of evidence from cross-sectional and longitudinal studies, we discussed the issue of the possible impact of antioxidant compounds from diet and supplementation on MCI and its progression to AD.
authors.affiliation: Geriatric Unit and Gerontology-Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. geriat.dot@geriatria.uniba.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Panza
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Solfrizzi
authors.forename: Davide
authors.initials: D
authors.lastname: Seripa
authors.forename: Bruno P
authors.initials: BP
authors.lastname: Imbimbo
authors.forename: Alberto
authors.initials: A
authors.lastname: Pilotto
authors.forename: Vincenza
authors.initials: V
authors.lastname: Frisardi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D008137:Longitudinal Studies; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species