title: [Roles of signal transduction pathway in non-Hodgkin's lymphoma].
abstract: The study of signal pathway has become a hotspot and a key in life science. In recent years, it has been found that many signaling pathways are associated with the occurrence, development, prognosis and drug resistance of many malignancies, including non-Hodgkin's lymphoma (NHL). Understanding the biological function of the signaling pathway and its relation with NHL, selectively controlling its biological activities may provide a new way for the treatment of NHL. In order to further investigate the function of signal pathways in pathogenesis, development and treatment of NHL, this review summarizes briefly the advances in the signal pathways related with the NHL including NF-κB, PI3K-AKT, Notch, Hh, MAPK, JAK-STAT, Wnt and cAMP.
authors.affiliation: Department of Hematology, Shandong University, Jinan 250021, Sandong Province, China.
authors.forename: Xi-Yuan
authors.initials: XY
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
mesh_terms: D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism*; D015398:Signal Transduction