title: Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the "Monzino 80-plus" prospective study.
abstract: The association among single nucleotide polymorphisms in inflammatory genes as interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β) or tumor necrosis factor alpha (TNF-α) and dementia has been explored mostly in Alzheimer's disease, while few data addressing their association with dementia in very old people are available. We performed a prospective, door-to-door population-based study of 80 years or older residents in eight municipalities of Varese province, Italy (the Monzino 80-plus study). No difference was found by a cross-sectional approach comparing IL-1α rs1800587, IL-1β rs3087258 and TNF-α rs1799724 genotypic and allelic frequencies between those affected and not affected by dementia. After a 5-year follow-up, the elderly carriers of T-allele of TNF-α rs1799724 were at an increased risk of dementia (p = 0.03). This association was no more significant adjusting for the apolipoprotein E epsilon-4 allele (APOE-ε4, p = 0.26), which was an independent predictor of dementia onset (p = 0.0002). In short, in this Italian population of oldest olds, dementia was associated to the APOE-ε4 allele only.
authors.affiliation: Laboratory of Biology of Neurodegenerative Disorders, Mario Negri Institute for Pharmacological Research, Milan, Italy. diego.albani@marionegri.it
authors.forename: Diego
authors.initials: D
authors.lastname: Albani
authors.forename: Mauro
authors.initials: M
authors.lastname: Tettamanti
authors.forename: Sara
authors.initials: S
authors.lastname: Batelli
authors.forename: Letizia
authors.initials: L
authors.lastname: Polito
authors.forename: Sabrina
authors.initials: S
authors.lastname: Dusi
authors.forename: Eleonora
authors.initials: E
authors.lastname: Ateri
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Forloni
authors.forename: Ugo
authors.initials: U
authors.lastname: Lucca
mesh_terms: D000368:Aged; D004247:DNA / Q000235:genetics*; D003704:Dementia / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D053582:Interleukin-1alpha / Q000235:genetics* / Q000378:metabolism; D053583:Interleukin-1beta / Q000235:genetics* / Q000378:metabolism; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance; D011446:Prospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000378:metabolism
chemical_list: D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D004247:DNA