title: Current serum lipoprotein levels and FMRI response to working memory in midlife.
abstract: OBJECTIVE
  Given that high cholesterol levels at midlife are a risk factor for future cognitive decline, the goal of the current study was to determine if cholesterol-related alterations in the cerebrovascular response to cognition could be detected at midlife.
  
  
  METHODS
  Forty adults, aged 40-60 years, performed a 2-Back working memory task during fMRI. The associations between serum total cholesterol, HDL-cholesterol, and total cholesterol/HDL-cholesterol concentrations to task-related activation intensity were modeled using multivariate multiple regression (two-tailed p < 0.02).
  
  
  RESULTS
  Higher levels of total cholesterol/HDL-cholesterol related to reduced working memory-related activation intensity in the left inferior parietal lobe, right superior frontal gyrus, and right middle frontal gyrus.
  
  
  CONCLUSIONS
  These data provide preliminary support for a deleterious effect of elevated total cholesterol/HDL-cholesterol ratio on cerebrovascular support for cognition in midlife.
authors.affiliation: Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA.
authors.forename: Mitzi M
authors.initials: MM
authors.lastname: Gonzales
authors.forename: Takashi
authors.initials: T
authors.lastname: Tarumi
authors.forename: Danielle E
authors.initials: DE
authors.lastname: Eagan
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Fedora O
authors.initials: FO
authors.lastname: Biney
authors.forename: Andreana P
authors.initials: AP
authors.lastname: Haley
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003071:Cognition; D003072:Cognition Disorders / Q000097:blood / Q000453:epidemiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000502:physiology; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL