title: [Correction of negative influence of long-term hypergastrinemia on gastric acid secretion].
abstract: We investigated the influence of long-term diminishing of gastric acid secretion in rats by H(+)-K(+)-ATPase omeprasole on the gastrin blood level and the basal gastric acid secretion. We performed an experimental analysis of possible prophylactic drugs of structural and functional changes in gastric mucosa evoked by hypergastrinemia. It was shown that following 28 days of omeprazole injections the blood gastrin level and the output of basal acid secretion increased by 189.3% and 173.9-283.7%, respectively. It was concluded that an augmentation of the output of basal acid secretion results from the development of parietal cells hyperplasia evoked by trophic action of gastrin. We also show here that agonists of nuclear peroxisome proliferator activator receptors pioglytasone and melanin effectively prevent the changes in gastric acid secretion as an index of morphological changes.
authors.forename: O I
authors.initials: OI
authors.lastname: Tsyriuk
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D005755:Gastrins / Q000097:blood*; D006965:Hyperplasia / Q000517:prevention & control; D008297:Male; D008543:Melanins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D009853:Omeprazole / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000077205:Pioglitazone; D011377:Proglumide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000897:Anti-Ulcer Agents; D005755:Gastrins; D008543:Melanins; D045162:Thiazolidinediones; D011377:Proglumide; D009853:Omeprazole; D000077205:Pioglitazone