title: Helicobacter pylori infection reduces the risk of esophageal squamous cell carcinoma: a case-control study in iran.
abstract: BACKGROUND
  Some studies have indicated a protective role of H.pylori against risk of esophageal squamous cell carcinoma (ESCC). The purpose of this study was to explore this possible relationship in a case-control study.
  
  
  METHODS
  One hundred consecutive patients diagnosed with ESCC and 100 healthy people were entered with informed consent. All were asked to provide a blood sample and serum immunoglobulin G (IgG) antibodies against HP-CSAs were measured with an enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  There was significant reverse association between H. pylori positivity and tumour development (OR=0.28, 95% CI: 0.15-0.54), but not with a Cag A positive status.
  
  
  CONCLUSIONS
  Our findings provide further evidence that H. pylori infection decreases the risk of ESCC but that this is not linked to a Cag A positive status.
authors.affiliation: Infectious Disease Research Center, Iran. Amin_phg@yahoo.com
authors.forename: Manouchehr
authors.initials: M
authors.lastname: Khoshbaten
authors.forename: Ali
authors.initials: A
authors.lastname: Zadimani
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Bonyadi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mohammadzadeh
authors.forename: Latif
authors.initials: L
authors.lastname: Gachkar
authors.forename: Mohamad Amin
authors.initials: MA
authors.lastname: Pourhoseingholi
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D000942:Antigens, Bacterial / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D004938:Esophageal Neoplasms / Q000097:blood* / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D005260:Female; D016481:Helicobacter Infections / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; C080866:cagA protein, Helicobacter pylori