title: A comparative infection study of pigeon and avian paramyxovirus type 1 viruses in pigeons: evaluation of clinical signs, virus shedding and seroconversion.
abstract: The pathogenesis of pigeon paramyxovirus type 1 (PPMV-1) isolate AV324/96 and of its recombinant derivative, rgAV324, was studied in pigeons. For comparison, the virulent chicken virus FL-Herts, which is a recombinant derivative of strain Herts/33, was also included. After inoculation by the combined intraocular, intranasal and intratracheal route, clinical signs, virus shedding and serological responses were examined. Clinical signs were observed only in the FL-Herts-infected group. All virus-inoculated pigeons had positive tracheal swabs until 5 days post infection. However, only the AV324/96-infected and rgAV324-infected birds, and not the FL-Herts-infected birds, shed virus in the cloaca. The AV324/96-infected pigeons showed higher mean antibody titres than the rgAV324-infected birds, whereas the antibody titres of the FL-Herts-infected group were rather low. The results show that the pigeon strain AV324 is not virulent for pigeons, but underlines the potential risk of poultry becoming infected by PPMV-1 shed by non-symptomatic pigeons.
authors.affiliation: Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands.
authors.forename: J C F M
authors.initials: JC
authors.lastname: Dortmans
authors.forename: G
authors.initials: G
authors.lastname: Koch
authors.forename: P J M
authors.initials: PJ
authors.lastname: Rottier
authors.forename: B P H
authors.initials: BP
authors.lastname: Peeters
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D002645:Chickens / Q000821:virology; D002988:Cloaca / Q000821:virology; D010856:Columbidae / Q000821:virology*; D009521:Newcastle Disease / Q000276:immunology / Q000473:pathology / Q000821:virology*; D009522:Newcastle disease virus / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology*; D011200:Poultry / Q000821:virology; D011201:Poultry Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology*; D014132:Trachea / Q000821:virology; D014774:Virulence; D017201:Virus Shedding / Q000502:physiology*
chemical_list: D000914:Antibodies, Viral