title: Nanoparticles targeting HLA-G for gene therapy in cancer.
abstract: Cancer cells are aided by immune-tolerant functions of HLA-G to escape the immune surveillance. In general, cancer cells can express membranous HLA-G, secrete soluble HLA-G, produce HLA-G positive exosomes, and can be subjected to proteolytic cleavage by matrix metalloproteinases releasing shedding HLA-G1 in stressful conditions. Thus, the downregulation of HLA-G either in transcripts or proteins may affect positively cancer therapy. The aim of this study was to examine the molecular nanoparticles targeting HLA-G. Special focus was accorded to RNA interference particles. Although numerous studies have reported the importance of HLA-G gene expression modulation by nanoparticles, no studies have investigated clinically their efficiency in this modulation.
authors.affiliation: Laboratory of Biochemistry, Research Unit 02/UR/09-01, Higher Institute of Biotechnology of Monastir, BP 74, Avenue Tahar Haddad, 5000 Monastir, Tunisia. ines.zidi@techemail.com
authors.forename: Ines
authors.initials: I
authors.lastname: Zidi
authors.forename: Nidhal
authors.initials: N
authors.lastname: Ben Amor
mesh_terms: D015316:Genetic Therapy; D059951:HLA-G Antigens / Q000737:chemistry* / Q000235:genetics*; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D011379:Prognosis
chemical_list: D059951:HLA-G Antigens