title: [Benzimidazo-pyrimidino-imidazo-thiadiazines pharmacologically active].
abstract: The compounds with thiadiazine structure have numerous biological properties. They are known for antimycotic, antimicrobial, antiviral, vasodilatatory, antiarytmic, bronhodilatatory and antiagregant actions.
  
  
  METHODS
  In order to study the influence of the different substituents on pharmacological properties of the thiadiazine compounds new benzimidazo-pyrimidino-imidazo-thiadiazine derivatives with potential biological actions have been synthesized.
  
  
  RESULTS
  The optimal conditions of reaction have been established and the chemical structure of the synthesized compounds has been confirmed by elemental analysis and IR spectroscopy.
  
  
  CONCLUSIONS
  The calculated formula according to the elemental analysis results and the spectral characteristics are in good agreement with the expected structures proposed.
authors.affiliation: Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Farmacie, Disciplina de Chimie Farmaceutică.
authors.forename: Georgeta
authors.initials: G
authors.lastname: Rusu
authors.forename: Lenuţa
authors.initials: L
authors.lastname: Profire
authors.forename: Gh
authors.initials: G
authors.lastname: Dănilă
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D001554:Benzene / Q000737:chemistry* / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000737:chemistry / Q000494:pharmacology; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013829:Thiadiazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D001993:Bronchodilator Agents; D007093:Imidazoles; D010975:Platelet Aggregation Inhibitors; D011743:Pyrimidines; D013829:Thiadiazines; D014665:Vasodilator Agents; D001554:Benzene