title: Salidroside attenuates hydrogen peroxide-induced cell damage through a cAMP-dependent pathway.
abstract: Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H(2)O(2))-induced HL-7702 cell damage, inhibit H(2)O(2)-induced cytosolic free Ca2+ ([Ca2+]i) elevation, scavenge reactive oxygen species (ROS) and increase 3'-5'-cyclic adenosine monophosphate (cAMP) level in a dose-dependent manner, but it couldn't influence 3'-5'-cyclic guanosine monophosphate (cGMP) levels. Therefore, these results indicated that the antioxidant effects of salidroside were associated with down-regulation of [Ca2+]i, ROS occur via a cAMP-dependent pathway.
authors.affiliation: Institute of Zoonoses, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China. gshuang1973@126.com
authors.forename: Shuang
authors.initials: S
authors.lastname: Guan
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Wenhui
authors.initials: W
authors.lastname: Qian
authors.forename: Guoren
authors.initials: G
authors.lastname: Huang
authors.forename: Xuming
authors.initials: X
authors.lastname: Deng
authors.forename: Xuelin
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D002460:Cell Line; D000242:Cyclic AMP / Q000096:biosynthesis / Q000378:metabolism*; D006152:Cyclic GMP / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D010636:Phenols / Q000494:pharmacology*
chemical_list: D005960:Glucosides; D010636:Phenols; D006861:Hydrogen Peroxide; D000242:Cyclic AMP; D006152:Cyclic GMP; C009172:rhodioloside