title: Design and evaluation of ocusert for controlled delivery of flurbiprofen sodium.
abstract: OBJECTIVE
  The basic objective of this study is to develop the Flurbiprofen sodium soluble ocusert to increase patient compliance by improving local delivery of the drug.
  
  
  METHODS
  Three different polymers were used in combination to prepare the rate controlling membrane. The drug reservoir was prepared by using hydroxy propyl methyl cellulose. Ocuserts were evaluated for their physicochemical parameters. The optimized formulations were further evaluated for accelerated stability studies, eye irritancy tests, and for in vivo drug release studies.
  
  
  RESULTS
  Ocuserts were found stable at room temperature and showed a strong positive correlation between in vitro and in vivo drug release.
  
  
  CONCLUSIONS
  An appropriate combination of hydrophilic and hydrophobic polymers provides better control of drug delivery.
authors.affiliation: Institute of Pharmacy, Bundelkhand University, Jhansi, UP, India. kulhari.h@rediffmail.com
authors.forename: Hitesh
authors.initials: H
authors.lastname: Kulhari
authors.forename: Deep
authors.initials: D
authors.lastname: Pooja
authors.forename: Harihar
authors.initials: H
authors.lastname: Narayan
authors.forename: Lokesh
authors.initials: L
authors.lastname: Meena
authors.forename: S K
authors.initials: SK
authors.lastname: Prajapati
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D015195:Drug Design; D004341:Drug Evaluation; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D010349:Patient Compliance; D011817:Rabbits; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; C050528:Eudragit RS; D065347:Hypromellose Derivatives; D005480:Flurbiprofen; C013517:ethyl cellulose; D002482:Cellulose; D008747:Methylcellulose