title: Disseminated congenital toxoplasma infection with a type II strain.
abstract: Disseminated congenital toxoplasmosis mimicking septic shock is unusual. We report a fatal case of disseminated congenital toxoplasmosis that was acquired after a third trimester maternal primary infection. The child had severe pneumonitis, purpura, and hepatitis. After 5 days of treatment, quantitative polymerase chain reaction analysis showed that parasite loads in the serum and in tracheal aspirates had decreased. The child died of refractory hypoxemia. Genotyping revealed a type II strain.
authors.affiliation: Neonatal Intensive Care Unit, Institut de Puériculture, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Kieffer
authors.forename: Virginie
authors.initials: V
authors.lastname: Rigourd
authors.forename: Patrick
authors.initials: P
authors.lastname: Ikounga
authors.forename: Bettina
authors.initials: B
authors.lastname: Bessieres
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Magny
authors.forename: Philippe
authors.initials: P
authors.lastname: Thulliez
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000913:Antibodies, Protozoan / Q000276:immunology; D016054:DNA, Protozoan / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000276:immunology / Q000469:parasitology; D014122:Toxoplasma / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*
chemical_list: D000890:Anti-Infective Agents; D000913:Antibodies, Protozoan; D016054:DNA, Protozoan