title: Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors.
authors.affiliation: Department of Medicinal Chemistry, New Drug Discovery Division, Zydus Research Centre, Sarkhej-Bavla, N.H. 8A Moraiya, Ahmedabad 382210, India.
authors.forename: Dipam
authors.initials: D
authors.lastname: Patel
authors.forename: Mukul
authors.initials: M
authors.lastname: Jain
authors.forename: Shailesh R
authors.initials: SR
authors.lastname: Shah
authors.forename: Rajesh
authors.initials: R
authors.lastname: Bahekar
authors.forename: Pradip
authors.initials: P
authors.lastname: Jadav
authors.forename: Brijesh
authors.initials: B
authors.lastname: Darji
authors.forename: Yernaidu
authors.initials: Y
authors.lastname: Siriki
authors.forename: Debdutta
authors.initials: D
authors.lastname: Bandyopadhyay
authors.forename: Amit
authors.initials: A
authors.lastname: Joharapurkar
authors.forename: Samadhan
authors.initials: S
authors.lastname: Kshirsagar
authors.forename: Harilal
authors.initials: H
authors.lastname: Patel
authors.forename: Mubeen
authors.initials: M
authors.lastname: Shaikh
authors.forename: Kalapatapu V V M
authors.initials: KV
authors.lastname: Sairam
authors.forename: Pankaj
authors.initials: P
authors.lastname: Patel
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008958:Models, Molecular; D011485:Protein Binding; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D014230:Triazoles; C012771:benzotriazole; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1