title: Coronary artery bypass surgery provokes Alzheimer's disease-like changes in the cerebrospinal fluid.
abstract: Several biomarkers are used in confirming the diagnosis of cognitive disorders. This study evaluates whether the level of these markers after heart surgery correlates with the development of cognitive dysfunction, which is a frequent complication of cardiac interventions. Concentrations of amyloid-β peptide, tau, and S100β in the cerebro-spinal fluid were assessed, as well as cognitive functions were evaluated before and after coronary artery bypass grafting, utilizing immuno-assays and psychometric tests, respectively. A drastic rise in the level of S100β was observed one week after the surgery, a mark of a severe generalized cerebral injury. The level of amyloid-β peptide significantly decreased, whereas the concentration of tau markedly increased six months postoperatively. Gradual cognitive decline was also present. These findings clearly demonstrate post-surgical cognitive impairment associated with changes in biomarkers similar to that seen in Alzheimer's disease, suggesting a unifying pathognomic factor between the two disorders. A holistic approach to coronary heart disease and Alzheimer's type dementia is proposed.
authors.affiliation: Asklepios-Med(private practice and research center), Szeged, Hungary. palotas@asklepiosmed.eu
authors.forename: András
authors.initials: A
authors.lastname: Palotás
authors.forename: Helton J
authors.initials: HJ
authors.lastname: Reis
authors.forename: Gábor
authors.initials: G
authors.lastname: Bogáts
authors.forename: Barna
authors.initials: B
authors.lastname: Babik
authors.forename: Mihály
authors.initials: M
authors.lastname: Racsmány
authors.forename: Linda
authors.initials: L
authors.lastname: Engvau
authors.forename: Eva
authors.initials: E
authors.lastname: Kecskeméti
authors.forename: Anna
authors.initials: A
authors.lastname: Juhász
authors.forename: Luciene B
authors.initials: LB
authors.lastname: Vieira
authors.forename: Antônio L
authors.initials: AL
authors.lastname: Teixeira
authors.forename: Marat A
authors.initials: MA
authors.lastname: Mukhamedyarovi
authors.forename: Albert A
authors.initials: AA
authors.lastname: Rizvanov
authors.forename: Mehmet E
authors.initials: ME
authors.lastname: Yalvaç
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Guimarães
authors.forename: Cláudia N
authors.initials: CN
authors.lastname: Ferreira
authors.forename: Andrey L
authors.initials: AL
authors.lastname: Zefirov
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Kiyasov
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Janka
authors.forename: János
authors.initials: J
authors.lastname: Kálmán
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003072:Cognition Disorders / Q000134:cerebrospinal fluid / Q000175:diagnosis; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000134:cerebrospinal fluid / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D010865:Pilot Projects; D011183:Postoperative Complications / Q000134:cerebrospinal fluid / Q000175:diagnosis; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000134:cerebrospinal fluid; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D009414:Nerve Growth Factors; D010446:Peptide Fragments; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C075222:amyloid beta-protein (1-42); D016875:tau Proteins