title: [Antigenic peptides for peptide splicing in the proteosome].
abstract: These past years, we focused our researches on the identification of novel, potential peptide targets for cancer immunotherapy. Amongst the peptides we identified, two are composed of fragments originally distant in the parental protein and are produced by a novel mechanism termed peptide splicing. The peptide splicing reaction takes place in the proteasome and occurs by transpeptidation. Here, we describe the discovery of this new mechanism of production of antigenic peptides.
authors.affiliation: Institut Ludwig pour la Recherche contre le Cancer, Branche de Bruxelles et Institut de Duve, Université Catholique de Louvain, Bruxelles, Belgique.
authors.forename: N
authors.initials: N
authors.lastname: Vigneron
mesh_terms: D000818:Animals; D000941:Antigens / Q000378:metabolism*; D051521:Fibroblast Growth Factor 5 / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D019154:Protein Splicing / Q000502:physiology*
chemical_list: D000941:Antigens; C496449:FGF5 protein, human; D010446:Peptide Fragments; D051521:Fibroblast Growth Factor 5; D046988:Proteasome Endopeptidase Complex