title: Simulating human cardiac electrophysiology on clinical time-scales.
abstract: In this study, the feasibility of conducting in silico experiments in near-realtime with anatomically realistic, biophysically detailed models of human cardiac electrophysiology is demonstrated using a current national high-performance computing facility. The required performance is achieved by integrating and optimizing load balancing and parallel I/O, which lead to strongly scalable simulations up to 16,384 compute cores. This degree of parallelization enables computer simulations of human cardiac electrophysiology at 240 times slower than real time and activation times can be simulated in approximately 1 min. This unprecedented speed suffices requirements for introducing in silico experimentation into a clinical workflow.
authors.affiliation: Division of Imaging Sciences, School of Medicine, Kings College London London, UK.
authors.forename: Steven
authors.initials: S
authors.lastname: Niederer
authors.forename: Lawrence
authors.initials: L
authors.lastname: Mitchell
authors.forename: Nicolas
authors.initials: N
authors.lastname: Smith
authors.forename: Gernot
authors.initials: G
authors.lastname: Plank