title: Enantioselective synthesis of β-substituted cyclic ketones via cobalt-catalyzed asymmetric reductive coupling of alkynes with alkenes.
abstract: A CoI(2)/(R)-BINAP, Zn, ZnI(2), H(2)O system efficiently catalyzes the intermolecular asymmetric reductive coupling of alkynes with cyclic enones to afford highly regio- and enantioselective β-alkenyl cyclic ketones. A possible mechanism that involves the formation of a cobaltacyclopentene intermediate from the alkyne and cyclic enone is proposed.
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Chu-Hung
authors.initials: CH
authors.lastname: Wei
authors.forename: Subramaniyan
authors.initials: S
authors.lastname: Mannathan
authors.forename: Chien-Hong
authors.initials: CH
authors.lastname: Cheng