title: [New aspects of using dihydropyridine calcium antagonists during coronary bypass surgery].
abstract: OBJECTIVE
  To study the contractile properties of the human radial artery (RA) and to provide a comparative clinical assessment of the results of autoarterial coronary bypass surgery (AACBS) using calcium antagonists (CA).
  
  
  METHODS
  Human RA smooth muscle samples (n = 49) taken at AACBS were experimentally studied. Mechanography was used to record the contractile responses of isolated smooth muscle samples to the contractile properties of a RA segment exposed to the liquid vasodilators nifedipine, papaverine, and sodium nitroprusside. The study enrolled 106 patients who had undergone surgical revascularization applying 2 autoarteries or more. Dihydropyridine CAs, such as adulat, norvask, and felodip, were administered by the developed protocol.
  
  
  RESULTS
  Adalat experimentally showed a pronounced dose-dependence of vasodilation and long-term aftereffects, which allows the CA to be regarded as the most attractive agent for the intraoperative preparation of an autoarterial shunt.
  
  
  CONCLUSIONS
  The systemic use of a dihydropyridine CA in a clinical trial could reduce the incidence of early autoarterial conduit dysfunction and improve prognosis in the patients.
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Vecherskiĭ
authors.forename: S L
authors.initials: SL
authors.lastname: Andreev
authors.forename: B Iu
authors.initials: BIu
authors.lastname: Murashev
mesh_terms: D017311:Amlodipine / Q000008:administration & dosage; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D008875:Middle Aged; D016896:Treatment Outcome; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D002121:Calcium Channel Blockers; D017311:Amlodipine