title: Neurobiological characterization of bipolar affective disorders : a focus on tardive dyskinesia and soft neurological signs in relation to serum dopamine Beta hydroxylase activity.
abstract: In this study, the prognostic determinants were investigated involving bipolar patients classified into two groups-one with favourable course and outcome, and the other with clearly unfavourable prognosis, based on certain recommended criteria, with intermediate prognosis were excluded. As compared to the poor prognosis group, the good prognosis group had lower social dysfunctions, lower ratings on psychopathotogy fewer indicators of neurodysfunction in form of neurological soft signs (NSS) and tardive dyskinesia (TD). The poor prognosis group was characterized by: (i) older age at onset; (ii) more manic than depressive episodes (5:1) and (HI) lower levels of serum dopamine-β-hydroxylase activity (DBH). The association between poor prognosis bipolar disorder having neuroleptic intolerance (TD and NSS) with low serum DBH, suggests that it is genetically governed. Further research in this direction seems in order, particularly the follow up of first episode manic disorders.
authors.affiliation: UTPAL GOSWAMI, M.D., Professor of Psychiatry & Drug de-addiction Centre, Lady Hardinge Medical College & Associated Hospital, New Delhi - 110 001.
authors.forename: U
authors.initials: U
authors.lastname: Goswami
authors.forename: S
authors.initials: S
authors.lastname: Basu
authors.forename: U
authors.initials: U
authors.lastname: Khastgir
authors.forename: U
authors.initials: U
authors.lastname: Kumar
authors.forename: R
authors.initials: R
authors.lastname: Chandrasekaran
authors.forename: B N
authors.initials: BN
authors.lastname: Gangadhar
authors.forename: R
authors.initials: R
authors.lastname: Sagar
authors.forename: J S
authors.initials: JS
authors.lastname: Bapna
authors.forename: S M
authors.initials: SM
authors.lastname: Channabasavanna
authors.forename: P B
authors.initials: PB
authors.lastname: Moore
authors.forename: I N
authors.initials: IN
authors.lastname: Ferrier