title: Control of peptide nanotube diameter by chemical modifications of an aromatic residue involved in a single close contact.
abstract: Supramolecular self-assembly is an attractive pathway for bottom-up synthesis of novel nanomaterials. In particular, this approach allows the spontaneous formation of structures of well-defined shapes and monodisperse characteristic sizes. Because nanotechnology mainly relies on size-dependent physical phenomena, the control of monodispersity is required, but the possibility of tuning the size is also essential. For self-assembling systems, shape, size, and monodispersity are mainly settled by the chemical structure of the building block. Attempts to change the size notably by chemical modification usually end up with the loss of self-assembly. Here, we generated a library of 17 peptides forming nanotubes of monodisperse diameter ranging from 10 to 36 nm. A structural model taking into account close contacts explains how a modification of a few Å of a single aromatic residue induces a fourfold increase in nanotube diameter. The application of such a strategy is demonstrated by the formation of silica nanotubes of various diameters.
authors.affiliation: Unité Mixte de Recherche 6251, Centre National de la Recherche Scientifique and Université Rennes 1, F-35 Rennes, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Tarabout
authors.forename: Stéphane
authors.initials: S
authors.lastname: Roux
authors.forename: Frédéric
authors.initials: F
authors.lastname: Gobeaux
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fay
authors.forename: Emilie
authors.initials: E
authors.lastname: Pouget
authors.forename: Cristelle
authors.initials: C
authors.lastname: Meriadec
authors.forename: Melinda
authors.initials: M
authors.lastname: Ligeti
authors.forename: Daniel
authors.initials: D
authors.lastname: Thomas
authors.forename: Maarten
authors.initials: M
authors.lastname: IJsselstijn
authors.forename: François
authors.initials: F
authors.lastname: Besselievre
authors.forename: David-Alexandre
authors.initials: DA
authors.lastname: Buisson
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Verbavatz
authors.forename: Michel
authors.initials: M
authors.lastname: Petitjean
authors.forename: Céline
authors.initials: C
authors.lastname: Valéry
authors.forename: Lionel
authors.initials: L
authors.lastname: Perrin
authors.forename: Bernard
authors.initials: B
authors.lastname: Rousseau
authors.forename: Franck
authors.initials: F
authors.lastname: Artzner
authors.forename: Maité
authors.initials: M
authors.lastname: Paternostre
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Cintrat
mesh_terms: D024322:Amino Acids, Aromatic / Q000737:chemistry; D008854:Microscopy, Electron; D008958:Models, Molecular; D015394:Molecular Structure; D036103:Nanotechnology; D045333:Nanotubes, Peptide / Q000737:chemistry* / Q000648:ultrastructure*; D010456:Peptides, Cyclic / Q000737:chemistry; D053838:Scattering, Small Angle; D012822:Silicon Dioxide / Q000737:chemistry; D013004:Somatostatin / Q000031:analogs & derivatives / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D024322:Amino Acids, Aromatic; D045333:Nanotubes, Peptide; D010456:Peptides, Cyclic; C060347:lanreotide; D013004:Somatostatin; D012822:Silicon Dioxide