title: 1H, 13C and 15N chemical shift assignments of IPSEΔNLS.
abstract: The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/alpha-1) is a major immunogenic component of schistosomes. It potently triggers the release of interleukin-4 from basophilic granulocytes in an IgE-dependent manner, suggesting a key function in the modulation of the host's immune response to Schistosoma mansoni infection. Here we present the near complete assignment of an IPSE/alpha-1 variant, IPSEΔNLS, which comprises the core domain of the protein.
authors.affiliation: Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.
authors.forename: N Helge
authors.initials: NH
authors.lastname: Meyer
authors.forename: Gabriele
authors.initials: G
authors.lastname: Schramm
authors.forename: Michael
authors.initials: M
authors.lastname: Sattler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004527:Egg Proteins / Q000737:chemistry*; D015801:Helminth Proteins / Q000737:chemistry*; D007554:Isotopes / Q000737:chemistry; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000737:chemistry; D012550:Schistosoma mansoni / Q000737:chemistry
chemical_list: D004527:Egg Proteins; D015801:Helminth Proteins; C474807:IPSE protein, Schistosoma mansoni; D007554:Isotopes; D011994:Recombinant Proteins