title: Effects of age on dopamine D2 receptor availability in striatal subdivisions: a high-resolution positron emission tomography study.
abstract: The purpose of the present study was to examine the relationship between age and dopamine D(2) receptor availability in striatal subdivisions of young and middle-aged healthy subjects using high-resolution positron emission tomography (PET) with [(11)C]raclopride to better characterize the nature of age-related decrements in striatal D(2) receptor availability. Twenty-four healthy volunteers completed 3-Tesla magnetic resonance imaging and high-resolution [(11)C]raclopride PET scans. The analyses using linear and exponential models revealed that age had a significant negative correlation with D(2) receptor availability in the post-commissural putamen (postPU) and that D(2) receptor binding in the postPU decreased significantly more with age than in the ventral striatum, suggesting subregional differences in age-related changes in D(2) receptor binding. The postPU, which belongs to the sensorimotor striatum, may be particularly vulnerable to the effects of age in young and middle-aged subjects.
authors.affiliation: Department of Psychiatry, Gil Hospital, Gachon University of Medicine and Science, Incheon, Republic of Korea.
authors.forename: Jong-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Young-Don
authors.initials: YD
authors.lastname: Son
authors.forename: Hang-Keun
authors.initials: HK
authors.lastname: Kim
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Lee
authors.forename: Seo-Eun
authors.initials: SE
authors.lastname: Cho
authors.forename: Young-Bo
authors.initials: YB
authors.lastname: Kim
authors.forename: Zang-Hee
authors.initials: ZH
authors.lastname: Cho
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D055815:Young Adult
chemical_list: D017448:Receptors, Dopamine D2