title: Immunologic considerations for generating memory CD8 T cells through vaccination.
abstract: Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration of antigenic, co-stimulatory and inflammatory signals undergo a programmed series of biological changes that ultimately results in the generation of memory cells. Memory CD8 T cells, in contrast to naïve cells, more effectively limit or prevent pathogen re-infection because of both qualitative and quantitative changes that occur following their induction. Unlike vaccination strategies aimed at generating antibody production, the ability to generate protective memory CD8 T cells has proven more complicated and problematic. However, recent experimental results have revealed important principles regarding the molecular and genetic basis for memory CD8 T cell formation, as well as identified ways to manipulate their development through vaccination, resulting in potential new avenues to enhance protective immunity.
authors.affiliation: Department of Microbiology Department of Pathology Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.
authors.forename: Noah S
authors.initials: NS
authors.lastname: Butler
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Nolz
authors.forename: John T
authors.initials: JT
authors.lastname: Harty
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D008954:Models, Biological; D014611:Vaccination / Q000379:methods*; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines