title: [Function of the antioxidant system in rats exposed to cadmium].
abstract: Lipid peroxidation (LPO) and antioxidant system functioning in the blood, liver and small intestine mucosal cells of rats under cadmium chloride intake and administration of the liposomal form of the biologically active supplement (BAS FLP-MD) have been studied. It is shown that cadmium chloride administration (1 mg/kg, 14 days) leads to the activation of the oxidative processes in the cells and decrease of the antioxidant enzyme activities including mitochondrial enzymes. The revealed inhibition of the hepatic superoxide dismutase (SOD) activity considerably determined by the effect on mitochondrial Cu, Zn-SOD. The effect of one-shot and long-term cadmium intake on the conjugation system and decrease of the tissue glutathione level were shown. BAS FLP-MD intake normalizes the oxidative processes possibly due to stabilization of the cellular components.
authors.forename: S V
authors.initials: SV
authors.lastname: Khyzhniak
authors.forename: A O
authors.initials: AO
authors.lastname: Prokhorova
authors.forename: V A
authors.initials: VA
authors.lastname: Hryshchenko
authors.forename: L I
authors.initials: LI
authors.lastname: Stepanova
authors.forename: L V
authors.initials: LV
authors.lastname: Sorokina
authors.forename: V A
authors.initials: VA
authors.lastname: Tomchuk
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002104:Cadmium / Q000633:toxicity*; D002374:Catalase / Q000097:blood / Q000378:metabolism; D019587:Dietary Supplements; D004785:Environmental Pollutants / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004785:Environmental Pollutants; D017392:Thiobarbituric Acid Reactive Substances; D002104:Cadmium; D002374:Catalase; D013482:Superoxide Dismutase