title: [Reversible optic neuropathy related to disulfiram].
abstract: OBJECTIVE
  To report a case of bilateral optic neuropathy, possibly caused by disulfiram.
  
  
  METHODS
  Clinical case report.
  
  
  RESULTS
  A 46-year-old patient, treated with disulfiram for the past 4 years for chronic alcoholism, presented with progressive bilateral, painless, severe visual loss, related to optic neuropathy. An extensive work-up did not disclose any other possible cause than a toxic optic neuropathy caused by disulfiram. Discontinuation of disulfiram resulted in rapid, complete visual recovery.
  
  
  CONCLUSIONS
  Disulfiram can cause toxic optic neuropathy, which can recover after discontinuing the medication, even after a long period of intoxication.
authors.affiliation: Service d'ophtalmologie, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 09, France. lecq_anne@yahoo.fr
authors.forename: A
authors.initials: A
authors.lastname: Trélohan
authors.forename: D
authors.initials: D
authors.lastname: Milea
mesh_terms: D000427:Alcohol Deterrents / Q000009:adverse effects*; D000437:Alcoholism / Q000188:drug therapy; D003117:Color Vision Defects / Q000139:chemically induced; D004221:Disulfiram / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000139:chemically induced*; D020127:Recovery of Function / Q000502:physiology; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000427:Alcohol Deterrents; D004221:Disulfiram