title: Ovarian hilus cell hyperplasia as the cause of virilization in 45,X Turner's syndrome.
abstract: OBJECTIVE
  To describe a rare case of 45,X Turner's syndrome with elevated T and clitoromegaly caused by ovarian hilus cell hyperplasia.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Tertiary care pediatric hospital.
  
  
  METHODS
  An 11-and-a-half-year-old girl with 45,X karyotype showed signs of accelerated growth and clitoromegaly and was found to have elevated serum T. Fluorescence in situ hybridization was used to confirm her karyotype as monosomy X and absence of the SRY gene. Elevated gonadotropins indicated absence of ovarian function.
  
  
  METHODS
  Laparoscopic bilateral gonadectomy.
  
  
  METHODS
  Serum T level.
  
  
  RESULTS
  Pathology showed ovarian hilus cell hyperplasia within the removed gonads. Serum T levels returned to normal after gonadectomy.
  
  
  CONCLUSIONS
  Ovarian hilus cell hyperplasia is an extremely rare cause of virilization in Turner's syndrome. Gonadectomy should be considered for patients with confirmed 45,X karyotype who exhibit virilization.
authors.affiliation: Washington Hospital Center, Washington, DC 20010, USA. Lauren.F.Damle@medstar.net
authors.forename: Lauren F
authors.initials: LF
authors.lastname: Damle
authors.forename: Veronica
authors.initials: V
authors.lastname: Gomez-Lobo
authors.forename: Amy R
authors.initials: AR
authors.lastname: Andrus
authors.forename: Paul B
authors.initials: PB
authors.lastname: Kaplowitz
mesh_terms: D002648:Child; D041321:Chromosomes, Human, X; D005260:Female; D006801:Humans; D006965:Hyperplasia; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D010535:Laparoscopy; D009006:Monosomy; D010053:Ovary / Q000473:pathology* / Q000601:surgery; D013739:Testosterone / Q000097:blood*; D016896:Treatment Outcome; D014424:Turner Syndrome / Q000097:blood / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D015854:Up-Regulation; D014770:Virilism / Q000097:blood / Q000235:genetics* / Q000473:pathology / Q000601:surgery
chemical_list: D013739:Testosterone