title: Gusanlungionosides A-D, potential tyrosinase inhibitors from Arcangelisia gusanlung.
abstract: Four new megastigmane glycosides, named gusanlungionosides A-D (1-4), together with 10 known compounds (5-14), were isolated from the stems of Arcangelisia gusanlung. The structures and absolute configurations of 1-4 were elucidated by comprehensive analysis of their NMR and CD data. Compounds 1-4 exhibited strong inhibitory effects not only on the mushroom tyrosinase activity in vitro but also on melanogenesis in cells.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Yu
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: Hu
authors.forename: Gang
authors.initials: G
authors.lastname: Ding
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Jian-He
authors.initials: JH
authors.lastname: Wei
authors.forename: Zhong-Mei
authors.initials: ZM
authors.lastname: Zou
authors.forename: Myeong-Hyeon
authors.initials: MH
authors.lastname: Wang
mesh_terms: D000363:Agaricales; D000818:Animals; D001483:Base Sequence; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D029583:Menispermaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D045792:Norisoprenoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry
chemical_list: D003512:Cyclohexanones; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006027:Glycosides; D008543:Melanins; D045792:Norisoprenoids; C413264:megastigmane; D014442:Monophenol Monooxygenase