title: Serum interleukin-6 may modulate periodontal inflammation in type 1 diabetic subjects.
abstract: OBJECTIVE
  To evaluate the associations between serum inflammatory biomarkers and periodontal inflammation in subjects with type 1 diabetes mellitus (T1DM). Our hypothesis was that local host responses may be modulated by the serum inflammatory mediators.
  
  
  METHODS
  Plaque, bleeding on probing and probing pocket depth (PD) were examined in 80 T1DM subjects at the baseline and in 58 subjects 8 weeks after periodontal therapy. The levels of glycosylated haemoglobin, serum interleukin (IL)-6, ultrasensitive C-reactive protein and the lipid profile were measured at the baseline and after therapy. Stratification of the sample separately by smoking and body mass index (BMI) was performed. Adjusted associations between the levels of systemic biomarkers and periodontal parameters were studied using multiple regression models.
  
  
  RESULTS
  The level of serum IL-6 was associated with the extent of bleeding and PD≥4 mm at the baseline in non-smokers and in subjects with BMI≤26 kg/m(2). These associations were also evident after periodontal therapy. Subjects with a high after-therapy IL-6 level presented poorer periodontal healing than those with a low level.
  
  
  CONCLUSIONS
  The observed associations may be considered to be suggestive of a modulatory effect of IL-6 on host responses in T1DM subjects.
authors.affiliation: Department of Periodontology and Geriatric Dentistry, University of Oulu, Oulu, Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Passoja
authors.forename: Matti
authors.initials: M
authors.lastname: Knuuttila
authors.forename: Liisa
authors.initials: L
authors.lastname: Hiltunen
authors.forename: Riitta
authors.initials: R
authors.lastname: Karttunen
authors.forename: Onni
authors.initials: O
authors.lastname: Niemelä
authors.forename: Taina
authors.initials: T
authors.lastname: Raunio
authors.forename: Olli
authors.initials: O
authors.lastname: Vainio
authors.forename: Pirjo
authors.initials: P
authors.lastname: Hedberg
authors.forename: Tellervo
authors.initials: T
authors.lastname: Tervonen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003773:Dental Plaque / Q000145:classification / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000145:classification / Q000628:therapy; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D010514:Periodontal Pocket / Q000145:classification / Q000628:therapy; D010518:Periodontitis / Q000097:blood* / Q000145:classification / Q000628:therapy; D012907:Smoking / Q000097:blood
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D018836:Inflammation Mediators; D015850:Interleukin-6; C508600:IL6 protein, human