title: Particular human leukocyte antigen alleles are associated with biochemical traits in the Japanese population.
abstract: We analyzed genetic associations among 7 biochemical traits (fasting plasma glucose, HbA1c, total cholesterol, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol, triglyceride, and uric acid) and 6 HLA loci using 1,616 individuals who visited the Health Evaluation and Promotion Center at Tokai University Hospital. Significant differences between the individuals carrying particular HLA alleles and those not carrying the alleles in certain biochemical traits were observed by Mann-Whitney U test. In female subjects, DPB1*03:01 was significantly associated with HbA1c (p = 0.0000665), and DRB1*14:03 was associated with total cholesterol concentration (p = 0.0015). In male subjects, C*14:02 demonstrated significant associations with fasting plasma glucose with p values of 0.0041. By contrast, Fisher's exact test indicated that female DRB1*14:03 was associated with a high concentration of total cholesterol (p = 000323, odds ratio [OR] = 4.32, 95% confidence interval [95% CI] = 1.83-10.36), whereas female DPB1*02:01 had a protective effect against a high concentration of LDL cholesterol (p =0.0043, OR = 0.41, 95% CI = 0.19-0.79). These associations have a statistical power of more than 0.8 and still retain significance after Bonferroni correction.
authors.affiliation: Department of Molecular Life Sciences, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Mitsunaga
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Homma
authors.forename: Akira
authors.initials: A
authors.lastname: Narita
authors.forename: Koichi
authors.initials: K
authors.lastname: Kashiwase
authors.forename: Yuko
authors.initials: Y
authors.lastname: Okudaira
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shiina
authors.forename: Ituro
authors.initials: I
authors.lastname: Inoue
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008875:Middle Aged; D040641:Quantitative Trait Loci / Q000235:genetics*
chemical_list: D006680:HLA Antigens