title: Photoprotective effects of topical formulations containing a combination of Ginkgo biloba and green tea extracts.
abstract: The beneficial photoprotective effects of topical formulations containing combined extracts of Ginkgo biloba (GB) and green tea (GT) have not been investigated. The present study aims to assess the photoprotective effects of topical formulations containing GB and GT combined or not by applications on the dorsal skin of hairless mice prior to UVA/B irradiation. After 20 h, skin barrier damage (TEWL), erythema, histological alterations and sunburn cell formation were evaluated. The results showed that only extract supplemented formulations protected the skin against the UV-induced damage. Formulations containing GB provided total protection of the skin barrier function avoiding UV radiation damage such as TEWL and erythema and were more effective than those containing GT. However, it is suggested that formulations containing combined GB and GT may provide substantial photoprotective effects since different aspects of skin damage were influenced by each extract.
authors.affiliation: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Department of Pharmaceutical Sciences, Av. do Café s/n, Ribeirão Preto, Brazil. pmcampos@usp.br
authors.forename: Susi Elaine
authors.initials: SE
authors.lastname: Dal Belo
authors.forename: Lorena Rigo
authors.initials: LR
authors.lastname: Gaspar
authors.forename: Patrícia Maria Berardo Gonçalves
authors.initials: PM
authors.lastname: Maia Campos
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004890:Erythema / Q000473:pathology; D020441:Ginkgo biloba / Q000737:chemistry*; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D010936:Plant Extracts / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D013471:Sunburn / Q000517:prevention & control*; D013473:Sunscreening Agents / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D010936:Plant Extracts; D013473:Sunscreening Agents; D013662:Tea