title: Psoriasin: key molecule of the cutaneous barrier?
abstract: Psoriasin (S100 A7) was discovered two decades ago as a protein abundantly expressed in psoriatic keratinocytes. Even though much scientific research has been carried out on the characterization of psoriasin, only recent studies point to an important role of psoriasin as an antimicrobial and immunomodulatory protein in skin and other epithelia. In this review, we provide an overview of the major findings in psoriasin research and discuss novel studies highlighting the role of psoriasin as an important effector molecule of the cutaneous barrier.
authors.affiliation: Department of Dermatology, Venereology and Allergy, University Clinic Schleswig-Holstein, Campus Kiel, Germany. rglaeser@dermatology.uni-kiel.de
authors.forename: Regine
authors.initials: R
authors.lastname: Gläser
authors.forename: Bente
authors.initials: B
authors.lastname: Köten
authors.forename: Maike
authors.initials: M
authors.lastname: Wittersheim
authors.forename: Jürgen
authors.initials: J
authors.lastname: Harder
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D056747:Immunomodulation / Q000235:genetics; D015603:Keratinocytes / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D011565:Psoriasis / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins / Q000235:genetics*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012869:Skin Absorption / Q000235:genetics*; D012871:Skin Diseases / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology; D014947:Wounds and Injuries / Q000235:genetics / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; C089242:S100A7 protein, human