title: Risk predisposition for Crohn disease: a "ménage à trois" combining IRGM allele, miRNA and xenophagy.
abstract: Susceptibility to Crohn disease (CD), an inflammatory bowel disease, is influenced by common variants at many loci like the exonic synonymous IRGM SNP (rs10065172, NM_001145805.1, c.313C>T). We recently showed that miR-196 is overexpressed in the inflammatory intestinal epithelia of individuals with CD and downregulates the IRGM protective (c.313C) but not the risk-associated (c.313T) allele. Eventually, loss of: IRGM/miRNA regulation compromises xenophagy. These results highlight a critical "ménage à trois" in risk susceptibility combining IRGM allele, miRNA and xenophagy.
authors.affiliation: INSERM ERI-21 and Université de Nice Sophia Antipolis, Faculté of Médecine, Nice, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Brest
authors.forename: Pierre
authors.initials: P
authors.lastname: Lapaquette
authors.forename: Baharia
authors.initials: B
authors.lastname: Mograbi
authors.forename: Arlette
authors.initials: A
authors.lastname: Darfeuille-Michaud
authors.forename: Paul
authors.initials: P
authors.lastname: Hofman
mesh_terms: D000483:Alleles; D001343:Autophagy / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D019204:GTP-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D012307:Risk Factors
chemical_list: D035683:MicroRNAs; D019204:GTP-Binding Proteins; C513539:IRGM protein, human