title: Assessment of the sedative effects of buprenorphine administered with 10 μg/kg detomidine in horses.
abstract: The aim of this randomised, observer-blinded, crossover study was to compare the effects of six treatments, administered intravenously to six horses: saline and saline (S/S); detomidine and saline (D/S); detomidine and 5 µg/kg buprenorphine (D/B5); detomidine and 7.5 µg/kg buprenorphine (D/B7.5); detomidine and 10 µg/kg buprenorphine (D/B10); and detomidine and 25 µg/kg butorphanol (D/BUT). The detomidine dose was 10 µg/kg for all treatments in which it was included. Sedation was subjectively assessed and recorded on a visual analogue scale. Peak sedation, duration of sedation and the area under the curve (AUC) for sedation scores were investigated using a univariate general linear model with post-hoc Tukey tests (P<0.05). Peak sedation and duration of sedation were statistically significantly different between treatments (P<0.001). No sedation was apparent after administration of S/S. The AUC was significantly different between treatments (P=0.010), with S/S being significantly different from D/S, D/BUT, D/B5 and D/B7.5, but not D/B10 (P=0.051).
authors.affiliation: Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, North Somerset BS40 5DU. emma.love@bristol.ac.uk
authors.forename: E J
authors.initials: EJ
authors.lastname: Love
authors.forename: P M
authors.initials: PM
authors.lastname: Taylor
authors.forename: J
authors.initials: J
authors.lastname: Murrell
authors.forename: H R
authors.initials: HR
authors.lastname: Whay
authors.forename: A E
authors.initials: AE
authors.lastname: Waterman-Pearson
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002047:Buprenorphine / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D006736:Horses / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007093:Imidazoles / Q000008:administration & dosage; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D011897:Random Allocation; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D007093:Imidazoles; D002047:Buprenorphine; C041255:detomidine