title: A Comparison of Sonographic Assessments and Clinical Questionnaire in the Diagnosis of HIV-Associated Lipodystrophy.
abstract: The study evaluated the use of sonographic measurements as an alternative to assessments based on clinical or other imaging techniques for the diagnosis of body-fat abnormalities. The study enrolled 179 HIV-infected patients, 81 (45.3%) of them diagnosed as lipodystrophy (LD)-positive based on a clinical standard questionnaire. Association between clinical LD and sonographic measurements of face, right upper limb, subcutaneous abdomen, and visceral compartments was evaluated by multiple logistic regression. The predicted probability of the logistic model was 0.64, corresponding to a maximum sensitivity of 69.1% (58%-79%), a specificity of 94.9% (88%-98%), and to positive and negative predictive values of 92% (82%-97%) and 79% (70%-86%), respectively. Kappa measure of concordance was 65% (54%-77%). Low sensitivity poses a problem for the use of sonography to detect LD in the clinical routine as a single exam, speaking in favor of the combined use of clinical and sonographic measurements over time.
authors.affiliation: 1 Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Clínica Médica B, Rua Mariz e Barros, Tijuca, Rio de Janeiro, Brazil.
authors.forename: Dario José Hart Pontes
authors.initials: DJ
authors.lastname: Signorini
authors.forename: Ana Maria Schmidt de Oliveira
authors.initials: AM
authors.lastname: Netto
authors.forename: Sergio
authors.initials: S
authors.lastname: Gabbay
authors.forename: Michelle Carreira Miranda
authors.initials: MC
authors.lastname: Monteiro
authors.forename: Dario Hart
authors.initials: DH
authors.lastname: Signorini
authors.forename: Marion de Fátima Castro de
authors.initials: Mde F
authors.lastname: Andrade
authors.forename: Francisco I
authors.initials: FI
authors.lastname: Bastos
authors.forename: Cláudia Torres
authors.initials: CT
authors.lastname: Codeço
mesh_terms: D000273:Adipose Tissue; D015658:HIV Infections; D039682:HIV-Associated Lipodystrophy Syndrome; D006801:Humans; D008060:Lipodystrophy; D011795:Surveys and Questionnaires