title: Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II)(2)Cys(6) transcriptional activator and induced by kojic acid at the transcriptional level.
abstract: A gene encoding the Zn(II)(2)Cys(6) transcriptional factor is clustered with two genes involved in biosynthesis of a secondary metabolite, kojic acid (KA), in Aspergillus oryzae. We determined that the gene was essential for KA production and the transcriptional activation of KA biosynthetic genes, which were triggered by the addition of KA.
authors.affiliation: National Institute of Advanced Industrial Science and Technology, AIST Tsukuba Central 6, Tsukuba, Ibaraki, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Marui
authors.forename: Noriko
authors.initials: N
authors.lastname: Yamane
authors.forename: Sumiko
authors.initials: S
authors.lastname: Ohashi-Kunihiro
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ando
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Terabayashi
authors.forename: Motoaki
authors.initials: M
authors.lastname: Sano
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ohashi
authors.forename: Eiji
authors.initials: E
authors.lastname: Ohshima
authors.forename: Kuniharu
authors.initials: K
authors.lastname: Tachibana
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Higa
authors.forename: Marie
authors.initials: M
authors.lastname: Nishimura
authors.forename: Hideaki
authors.initials: H
authors.lastname: Koike
authors.forename: Masayuki
authors.initials: M
authors.lastname: Machida
mesh_terms: D001236:Aspergillus oryzae / Q000235:genetics / Q000378:metabolism*; D003545:Cysteine / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D004271:DNA, Fungal / Q000378:metabolism; D005656:Fungal Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects*; D005800:Genes, Fungal; D011753:Pyrones / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000096:biosynthesis; D015533:Transcriptional Activation / Q000187:drug effects
chemical_list: D004271:DNA, Fungal; D005656:Fungal Proteins; D011753:Pyrones; D015534:Trans-Activators; D014157:Transcription Factors; C011890:kojic acid; D003545:Cysteine