title: Visfatin levels in Behcet's disease.
abstract: The aim of our study is to determine the serum visfatin levels of patients with Behcet's disease and to investigate the relationship between visfatin, an adipokine released from adipose tissue, levels and activity of Behcet's disease. Fifty-eight patients with Behcet's disease were enrolled to the study. Nineteen of the patients were inactive, and 39 of them were active. We enrolled 30 healthy subjects as being control group. Visfatin and tumor necrosis factor alpha (TNF-α) levels were measured with ELISA method. Visfatin levels were significantly lower in patients with Behcet's disease whose illnesses were active or inactive than the control group (p < 0.05). There was no significant difference between the active patient and inactive patient group. The reason for the lower levels of serum visfatin in active and inactive patients' group could be due to pro-inflammatory cytokines such as TNF-α and IL-6 which suppress genetic expression of visfatin in patients with Behcet's disease, or else.
authors.affiliation: School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Sezen
authors.forename: Seydi
authors.initials: S
authors.lastname: Okumus
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Pehlivan
authors.forename: Ismail
authors.initials: I
authors.lastname: Dilli
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tarakcioğlu
authors.forename: Ahmet Mesut
authors.initials: AM
authors.lastname: Onat
mesh_terms: D001528:Behcet Syndrome / Q000097:blood* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D054409:Nicotinamide Phosphoribosyltransferase