title: Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: difference in metabolism as a possible mechanism.
authors.affiliation: Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kijima
authors.forename: Tomohito
authors.initials: T
authors.lastname: Shimizu
authors.forename: Shinpei
authors.initials: S
authors.lastname: Nonen
authors.forename: Mitsugi
authors.initials: M
authors.lastname: Furukawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Otani
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Minami
authors.forename: Ryo
authors.initials: R
authors.lastname: Takahashi
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Hirata
authors.forename: Izumi
authors.initials: I
authors.lastname: Nagatomo
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kida
authors.forename: Sho
authors.initials: S
authors.lastname: Goya
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujio
authors.forename: Junichi
authors.initials: J
authors.lastname: Azuma
authors.forename: Isao
authors.initials: I
authors.lastname: Tachibana
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawase
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D066246:ErbB Receptors / Q000235:genetics; D000069347:Erlotinib Hydrochloride; D005260:Female; D000077156:Gefitinib; D006801:Humans; D007564:Japan; D008099:Liver / Q000187:drug effects*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics; D009154:Mutation; D011799:Quinazolines / Q000009:adverse effects* / Q000494:pharmacology*; D000637:Transaminases / Q000096:biosynthesis; D016896:Treatment Outcome
chemical_list: D011799:Quinazolines; D000069347:Erlotinib Hydrochloride; D000637:Transaminases; D066246:ErbB Receptors; D000077156:Gefitinib