title: Atherogenic changes of low-density lipoprotein susceptibility to oxidation, and antioxidant enzymes in pulmonary tuberculosis.
abstract: OBJECTIVE
  Tuberculosis remains one of the most common infectious diseases and a leading cause of mortality world wide. There is some evidence for the possible involvement of Mycobacterium tuberculosis in atherosclerosis. We aim to investigate total antioxidant capacity (TAC), red blood cell superoxide dismutase (SOD) activity, whole blood glutathione peroxidase (GPX) activity, low-density lipoprotein (LDL) susceptibility to oxidation, and malondialdehyde (MDA) levels in patients with pulmonary tuberculosis (PTB).
  
  
  METHODS
  Forty-five males with active PTB (case group) and 45 healthy age-matched males (control group) were enrolled in the study. TAC, SOD and GPX activities were determined by commercial ELISA kits. MDA levels were measured using the thiobarbituric acid method. LDL susceptibility to oxidation was assessed by measuring lag phase duration.
  
  
  RESULTS
  TAC, SOD and GPX activities, and lag phase duration in the case group were significantly lower than the control group (p=.002, p=.004, p=.008, and p=.004, respectively; independent), while the MDA levels was higher in case group (p=.024).
  
  
  CONCLUSIONS
  Our findings suggest a higher susceptibility of LDL to oxidation and higher levels of lipid peroxidation, and therefore, a possible higher risk of atherosclerosis in patients with PTB.
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. dr.nezami@gmail.com
authors.forename: Nariman
authors.initials: N
authors.lastname: Nezami
authors.forename: Amir
authors.initials: A
authors.lastname: Ghorbanihaghjo
authors.forename: Nadereh
authors.initials: N
authors.lastname: Rashtchizadeh
authors.forename: Hassan
authors.initials: H
authors.lastname: Argani
authors.forename: Arash
authors.initials: A
authors.lastname: Tafrishinejad
authors.forename: Sona
authors.initials: S
authors.lastname: Ghorashi
authors.forename: Babak
authors.initials: B
authors.lastname: Hajhosseini
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D050197:Atherosclerosis / Q000473:pathology*; D016022:Case-Control Studies; D004912:Erythrocytes / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000378:metabolism; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000378:metabolism* / Q000382:microbiology
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D010100:Oxygen