title: Differential diagnosis between fibroadenoma, giant fibroadenoma and phyllodes tumour: sonographic features and core needle biopsy.
abstract: OBJECTIVE
  The aim of this study was to analyse mammographic and ultrasound (US) features of fibroadenoma and phyllodes tumour and assess the diagnostic accuracy of mammography, US and US-guided core needle biopsy (CNB) in the differential diagnosis of these two lesions.
  
  
  METHODS
  The results of the pathological analysis of excision biopsy of 83 lesions (67 fibroadenomas and 16 phyllodes tumours) were correlated with the findings of mammography, US and US-guided CNB performed on 83 women with a mean age of 45.4 years (range 18-75 years).
  
  
  RESULTS
  Sensitivity, specificity and positive predictive values compared with histology were 45%, 50% and 79% for mammography, 34%, 69% and 82% for US and 81%, 97% and 87% for US-guided CNB (p=0.001).
  
  
  CONCLUSIONS
  The almost complete overlap between mammographic and US parameters of fibroadenomas and phyllodes tumours and the absence of pathognomonic features preclude the differential diagnosis between the two histological types. US-guided CNB is a valuable tool in the differential diagnosis between fibroadenoma and phyllodes tumour.
authors.affiliation: Dipartimento di Internistica Clinica e Sperimentale "Magrassi-Lanzara", Sezione di Radiodiagnostica e Radioterapia, Seconda Università degli Studi di Napoli, P.zza Miraglia 2, 80138 Napoli, Italy. ggatta@sirm.org
authors.forename: G
authors.initials: G
authors.lastname: Gatta
authors.forename: F
authors.initials: F
authors.lastname: Iaselli
authors.forename: V
authors.initials: V
authors.lastname: Parlato
authors.forename: G
authors.initials: G
authors.lastname: Di Grezia
authors.forename: R
authors.initials: R
authors.lastname: Grassi
authors.forename: A
authors.initials: A
authors.lastname: Rotondo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D018226:Fibroadenoma / Q000000981:diagnostic imaging*; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D003557:Phyllodes Tumor / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional; D016217:Ultrasonography, Mammary