title: Aminothiocarbamate-catalyzed asymmetric bromolactonization of 1,2-disubstituted olefinic acids.
abstract: An efficient and enantioselective bromolactonization of 1,2-disubstituted olefinic acids using an amino-thiocarbamate catalyst has been developed, resulting in the formation of δ-lactones containing two chiral centers with up to 99% yield, 95% ee.
authors.affiliation: Department of Chemistry, National University of Singapore, Singapore.
authors.forename: Chong Kiat
authors.initials: CK
authors.lastname: Tan
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.forename: Ying-Yeung
authors.initials: YY
authors.lastname: Yeung
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D006842:Hydrocarbons, Brominated; D007783:Lactones