title: Idiopathic neonatal necrotising fasciitis caused by community-acquired MSSA encoding Panton Valentine Leukocidin genes.
abstract: Neonatal necrotising fasciitis is very rare in comparison to the adult presentation of the disease and a Plastic Surgeon may only encounter one such case during his or her career. Often this is initially misdiagnosed and managed as simple cellulitis. It generally affects previously healthy babies, the site is often the lower back area and a history of minor skin trauma may be elicited. The causative organism is usually Streptococcus or polymicrobial, as is the case in the adult population. We present the case of a previously healthy 11-day-old infant with idiopathic, rapidly progressive necrotising fasciitis of the back, cause by Methicillin sensitive Staphylococcus aureus (MSSA) infection. The strain was isolated and found to encode the Panton-Valentine Leukocidin genes, which have been associated with particularly severe necrotising infections in other sites, with high mortality. These strains are the subject of specific treatment and eradication guidance in the UK but awareness of this and the importance of obtaining detailed culture typing is likely to be low amongst Plastic Surgeons.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland. rledunlop@gmail.com
authors.forename: Rebecca L E
authors.initials: RL
authors.lastname: Dunlop
authors.forename: Patricia
authors.initials: P
authors.lastname: Eadie
mesh_terms: D001427:Bacterial Toxins / Q000235:genetics; D015373:Bacterial Typing Techniques; D002081:Buttocks; D003131:Combined Modality Therapy; D017714:Community-Acquired Infections / Q000382:microbiology* / Q000628:therapy; D005098:Exotoxins / Q000235:genetics; D019115:Fasciitis, Necrotizing / Q000382:microbiology* / Q000628:therapy; D022761:Gene Transfer, Horizontal / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D007956:Leukocidins / Q000235:genetics; D008297:Male; D016106:Methicillin Resistance / Q000235:genetics; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000628:therapy; D013211:Staphylococcus aureus / Q000235:genetics
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin