title: Variability in activity and results from drug assessments by pharmacy and therapeutics committees in Spanish hospitals.
abstract: OBJECTIVE
  To quantify the Spanish Pharmacy and Therapeutics Committees (P&TC) activity with regard to assessing and selecting drugs and describing variability in decisions made to include them.
  
  
  METHODS
  Descriptive, cross-sectional study based on a questionnaire aimed to 513 hospitals with more than 75 beds. We included questions referring to the P&TC resolutions, the therapeutic positioning and assessment reports. Recruitment was carried out between November 2007 and January 2008. Variability among P&TC conclusions were presented in five categories or levels of coincidence.
  
  
  RESULTS
  One hundred and seventy-five hospitals participated, with a response rate of 34% (54% of beds). The mean (SD) number of drug-indications assessed per hospital was 10.35 (7.45). The proportion of assessments that conclude with drug inclusion or rejection was 75.3 and 21.4%, respectively. 16.2% concluded with therapeutic equivalence. Conditions for use were established for 64% of them, and 33% were included in a clinical guide. With regard to variability, 81.0% of assessments coincided with the conclusion to include or reject the drug. A contradictory decision was made for 19.0%.
  
  
  CONCLUSIONS
  Drug assessment and selection activity in hospitals involve an amount of work. The proportion of drugs approved is similar in different types of hospitals. There is extensive variability as regards deciding upon inclusion and is similar to studies conducted in other countries. They indicate that a standardising methodology would be recommendable.
authors.affiliation: Servicio de Farmacia, Hospital Universitario Son Dureta, Palma de Mallorca, España. francesc.puigventos@ssib.es
authors.forename: F
authors.initials: F
authors.lastname: Puigventós Latorre
authors.forename: B
authors.initials: B
authors.lastname: Santos-Ramos
authors.forename: A
authors.initials: A
authors.lastname: Ortega Eslava
authors.forename: M E
authors.initials: ME
authors.lastname: Durán-García
mesh_terms: D003430:Cross-Sectional Studies; D006761:Hospitals; D010607:Pharmacy Service, Hospital; D010606:Pharmacy and Therapeutics Committee / Q000592:standards; D017410:Practice Guidelines as Topic; D013030:Spain; D011795:Surveys and Questionnaires