title: Polyethylene glycol-functionalized benzylidene cyclopentanone dyes for two-photon excited photodynamic therapy.
abstract: A series of polyethylene glycol-functionalized benzylidene cyclopentanone dyes with varying lipid/water partition coefficients were synthesized in high yields by a simple process. Detailed characterization and systematic studies of these molecules, including linear and nonlinear photophysical properties, reactive oxygen yields, and in vitro photodynamic therapy (PDT) activities, were conducted. Four of these dyes exhibited good solubility in PBS (>2 mg ml(-1), which is sufficient for clinical venous injection), high reactive oxygen yields, large two-photon absorption and low dark toxicity, under the therapy dosage. Among them, two dyes could be absorbed efficiently by human rectal cancer 1116 cells, and presented strong two-photon excited PDT activity in in vitro cell experiments.
authors.affiliation: Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, PR China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Zhao
authors.forename: Weijia
authors.initials: W
authors.lastname: Wang
authors.forename: Feipeng
authors.initials: F
authors.lastname: Wu
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.forename: Naiyan
authors.initials: N
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.forename: Qianli
authors.initials: Q
authors.lastname: Zou
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001597:Benzylidene Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003517:Cyclopentanes / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008055:Lipids / Q000737:chemistry; D015394:Molecular Structure; D010778:Photochemotherapy; D017785:Photons; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001597:Benzylidene Compounds; D003517:Cyclopentanes; D005456:Fluorescent Dyes; D008055:Lipids; D017319:Photosensitizing Agents; D014867:Water; C007201:cyclopentanone; D011092:Polyethylene Glycols