title: SK2 channel expression and function in cerebellar Purkinje cells.
abstract: Small-conductance calcium-activated K(+) channels (SK channels) regulate the excitability of neurons and their responsiveness to synaptic input patterns. SK channels contribute to the afterhyperpolarization (AHP) following action potential bursts, and curtail excitatory postsynaptic potentials (EPSPs) in neuronal dendrites. Here we review evidence that SK2 channels are expressed in rat cerebellar Purkinje cells during development and throughout adulthood, and play a key role in diverse cellular processes such as the regulation of the spike firing frequency and the modulation of calcium transients in dendritic spines. In Purkinje cells as well as in other types of neurons, SK2 channel plasticity seems to provide an important mechanism allowing these cells to adjust their intrinsic excitability and to alter the probabilities for the induction of synaptic learning correlates, such as long-term potentiation (LTP).
authors.affiliation: Laboratoire Physiologie Cellulaire de la Synapse, CNRS, Bordeaux Neuroscience Institute, University of Bordeaux, 33077 Bordeaux Cedex, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Hosy
authors.forename: Claire
authors.initials: C
authors.lastname: Piochon
authors.forename: Eva
authors.initials: E
authors.lastname: Teuling
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Rinaldo
authors.forename: Christian
authors.initials: C
authors.lastname: Hansel
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D049229:Dendritic Spines / Q000502:physiology; D000081410:Germinal Center Kinases; D017774:Long-Term Potentiation / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis / Q000502:physiology*; D011689:Purkinje Cells / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000378:metabolism; D000099317:Hippo Kinases
chemical_list: D000081410:Germinal Center Kinases; D017346:Protein Serine-Threonine Kinases; C481222:Slk protein, rat; D000099317:Hippo Kinases