title: [Effects of different ventilation modes for one-lung ventilation anesthesia on respiratory function and F(A)/F(I) changes during sevoflurane inhalation].
abstract: OBJECTIVE
  To investigate the effects of different ventilation modes for one lung ventilation anesthesia on arterial blood-gas, airway pressure, intrapulmonary shunt, and F(A)/F(I) changes in patients receiving sevoflurane inhalation.
  
  
  METHODS
  Thirty ASA class II-III patients with lung cancer undergoing pulmonary lobectomy were randomized into 3 equal groups. The patients in group A received volume-controlled ventilation (VCV) without positive end-expiratory pressure (PEEP) (VT=8 ml/kg, Rf=12/min), and those in group B, after a preceding VCV stabilize the airway pressure, had pressure-controlled ventilation with maintenance of an identical peak pressure (Ppeak) (Rf=12/min, PEEP=0). In group C, the patients received small tidal volume ventilation with PEEP (VT=6 ml/kg, Rf=16/min, PEEP=5 cm H(2)O). Blood gas analysis was carried out at 10 min after TLV and at 20, 45 and 70 min after one lung ventilation (OLV); the heart rate (HR), mean arterial pressure (MAP), SpO(2) and Ppeak were also recorded and blood samples collected from the artery and jugular vein at these time points. Inhalation of 1.5% sevoflurane for 20 min started at 20 min of OLV.
  
  
  RESULTS
  Compared with those in TLV, the Ppeak increased, lung compliance decreased, arterial oxygenation (PaO(2)) decreased and intrapulmonary shunt (Qs/Qt) increased during OLV. Group B showed the fastest increase of F(A)/F(I) in the initial 8 min, followed by groups A and C, but the curves became similar with the passage of time.
  
  
  CONCLUSIONS
  During OLV, the 3 ventilation modes result in similar F(A)/F(I) changes during sevoflurane inhalation but PCV can increase pulmonary compliance.
authors.affiliation: Department of Anesthesiology, Jinhua Central Hospital, Jinhua 321000, China. ye-cathy@126.com
authors.forename: Fang-Fan
authors.initials: FF
authors.lastname: Ye
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000758:Anesthesia; D062186:Arterial Pressure; D005260:Female; D006801:Humans; D008170:Lung Compliance; D008175:Lung Neoplasms / Q000503:physiopathology*; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D061810:One-Lung Ventilation / Q000379:methods*; D011175:Positive-Pressure Respiration; D011659:Pulmonary Gas Exchange; D000077149:Sevoflurane; D055815:Young Adult
chemical_list: D008738:Methyl Ethers; D000077149:Sevoflurane