title: What is the role of antigen-processing mechanisms in autologous tolerogenic dendritic cell therapy in organ transplantation?
abstract: Injection of autologous tolerogenic dendritic cells is a promising strategy to diminish the burden of harmful immunosuppression in clinical transplantation. We discuss the immunoregulatory mechanisms triggered by this approach. Tolerogenic dendritic cells have long been associated with decreased antigen-processing capacities. However, different lines of evidence led us to propose that injected autologous dendritic cells may need to process donor antigens from graft passenger leukocytes. It is known that drugs such as calcineurin inhibitors can interfere with antigen processing. Indeed, this issue is of the most importance to rationalize the translation of autologous tolerogenic dendritic cell therapy to the clinic.
authors.affiliation: INSERM, UMR 643, Nantes, F44093, France. mhill@nantes.inserm.fr
authors.forename: Marcelo
authors.initials: M
authors.lastname: Hill
authors.forename: Mercedes
authors.initials: M
authors.lastname: Segovia
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Cuturi
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D064987:Cell- and Tissue-Based Therapy; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000637:transplantation; D006680:HLA Antigens / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance; D056747:Immunomodulation; D016377:Organ Transplantation; D014182:Transplantation, Autologous
chemical_list: D006680:HLA Antigens