title: [The application of chromatography and spectrometry for the analysis of ketorolac and diclofenac in biological fluids].
abstract: The objective of the present work was to study conditions for isolation of ketorolac and diclofenac from biological fluids. A method of their extraction with a mixture of organic solvents has been developed and the conditions for the identification of these compounds are proposed with the use of high performance liquid chromatography (HPLC), UV spectroscopy, and gas chromatography with electron capture detection (GC/ECD). The possibilities of using HPLC, UV spectrometry, and GC/ECD for quantitative determination of ketorolac and diclofenac are illustrated.
authors.forename: A A
authors.initials: AA
authors.lastname: Vatalev
authors.forename: A V
authors.initials: AV
authors.lastname: Kireeva
authors.forename: S V
authors.initials: SV
authors.lastname: Volchenko
authors.forename: V N
authors.initials: VN
authors.lastname: Kuklin
mesh_terms: D002849:Chromatography, Gas / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004008:Diclofenac / Q000097:blood*; D006801:Humans; D020910:Ketorolac / Q000097:blood*; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
chemical_list: D004008:Diclofenac; D020910:Ketorolac