title: Fast measurement of blood T1 in the human jugular vein at 3 Tesla.
abstract: Current T(1) values for blood at 3T largely came from in vitro studies on animal blood or freshly drawn human blood. Measurement of blood T(1) in vivo could provide more specific information, e.g., for individuals with abnormal blood composition. Here, blood T(1) at 3T was measured rapidly (<1 min) in the internal jugular vein using a fast inversion-recovery technique in which multiple inversion time can be acquired rapidly due to constant refreshing of blood. Multishot EPI acquisition with flow compensation yielded high resolution images with minimum partial volume effect. Results showed T(1) = 1852 ± 104 msec among 24 healthy adults, a value higher than for bovine blood phantoms (1584 msec at Hct of 42%). A second finding was that of a significant difference (P < 0.01) between men and women, namely T(1) = 1780 ± 89 msec (n = 12) and T(1) = 1924 ± 58 msec (n = 12), respectively. This difference in normal subjects is tentatively explained by the difference in Hct between genders. Interestingly, however, studies done on sickle cell anemia patients with much lower Hct (23 ± 3%, n = 10) revealed similar venous blood T(1) = 1924 ± 82 msec, indicating other possible physical influences affecting blood T(1).
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. qin@mri.jhu.edu
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.forename: John J
authors.initials: JJ
authors.lastname: Strouse
authors.forename: Peter C M
authors.initials: PC
authors.lastname: van Zijl
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D002648:Child; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007601:Jugular Veins; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen