title: Synthesis of 2-thio-substituted benzothiazoles via a domino condensation/S-arylation/heterocyclization process.
abstract: Condensation of carbon disulfide with thiols in the presence of K(2)CO(3) generates carbonotrithioate salts in situ, which undergo coupling with 2-iodoanilines and subsequent intramolecular condensation and elimination under assistance of CuBr to afford 2-thio-substituted benzothiazoles. Both aliphatic and aromatic thiols are compatible with this process, delivering the corresponding heterocycles with good diversity.
authors.affiliation: Department of Chemistry, Shanghai University, Shanghai 200444, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Shi
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Yongwen
authors.initials: Y
authors.lastname: Jiang
authors.forename: Dawei
authors.initials: D
authors.lastname: Ma
mesh_terms: D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D003500:Cyclization; D013455:Sulfur / Q000737:chemistry*
chemical_list: D052160:Benzothiazoles; D013455:Sulfur