title: Diffuse large B-cell lymphoma carrying both t(3 ; 7)(q27 ; p12) and t(8 ; 14)(q24 ; q32).
abstract: We report a 60-year-old man with diffuse large B-cell lymphoma harboring both t(3 ; 7)(q27 ; p12) and t(8 ; 14)(q24 ; q32). Although he received six courses of conventional combination chemotherapy plus rituximab, early relapse occurred. Four courses of an intensive salvage regimen and high-dose chemotherapy with autologous peripheral blood stem cell transplantation were performed. The patient has remained in complete remission for over 24 months. This case is noteworthy because both genetic abnormalities are implicated in lymphomagenesis.
authors.affiliation: Department of Hematology, Mito Medical Center, National Hospital Organization, Japan.
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Katsura
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Ohta
authors.forename: Chikashi
authors.initials: C
authors.lastname: Yoshida
authors.forename: Haruo
authors.initials: H
authors.lastname: Ohtani
authors.forename: Takuya
authors.initials: T
authors.lastname: Komeno
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D016259:Genes, myc; D006801:Humans; D051740:Ikaros Transcription Factor / Q000235:genetics; D007621:Karyotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D050596:Oncogene Fusion; D036102:Peripheral Blood Stem Cell Transplantation; D051560:Proto-Oncogene Proteins c-bcl-6; D012074:Remission Induction; D000069283:Rituximab; D016879:Salvage Therapy; D014178:Translocation, Genetic; D014182:Transplantation, Autologous
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; C497239:IKZF1 protein, human; D051560:Proto-Oncogene Proteins c-bcl-6; D051740:Ikaros Transcription Factor; D000069283:Rituximab