title: Saffron (Crocus sativus) aqueous extract and its constituent crocin reduces stress-induced anorexia in mice.
abstract: In the present study, the effects of an ethanol and aqueous extract of saffron Crocus sativus and its constituents safranal and crocin on the stress-induced reduction in food intake, weight gain and anorexic time in mice were investigated. Male albino mice (20-25 g) were irregularly exposed to a trial of electroshock stress for 7 days. Then, the anorexic time as well as the animal's food intake and weight were recorded. In addition, blood samples were obtained on days 1 and 7 for corticosterone determination. Intraperitoneal (i.p.) administration of the aqueous but not the ethanol extract (10, 50 and 100 mg/kg) significantly reduced the anorexic time. The results were similar for crocin (1, 5 and 10 mg/kg; i.p.). In addition, a reduction in weight gain was observed in the controls as well as in the groups that received alcohol extract or safranal. However, this was not observed in animals treated with aqueous extract or crocin. The plasma corticosterone level did not increase in the aqueous extract and crocin treated animals. It can be concluded that the saffron aqueous extract and its constituent crocin reduce side effects of electroshock stress in mice.
authors.affiliation: Department of Biology, Faculty of Science, Islamic AZAD University, North Tehran Branch, Tehran, Iran.
authors.forename: Bahar-al-Sadat
authors.initials: BA
authors.lastname: Halataei
authors.forename: Maryam
authors.initials: M
authors.lastname: Khosravi
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Arbabian
authors.forename: Hedayat
authors.initials: H
authors.lastname: Sahraei
authors.forename: Leila
authors.initials: L
authors.lastname: Golmanesh
authors.forename: Homeira
authors.initials: H
authors.lastname: Zardooz
authors.forename: Cyrus
authors.initials: C
authors.lastname: Jalili
authors.forename: Hassan
authors.initials: H
authors.lastname: Ghoshooni
mesh_terms: D000818:Animals; D000855:Anorexia / Q000188:drug therapy*; D001835:Body Weight; D002338:Carotenoids / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood; D027622:Crocus / Q000737:chemistry*; D053138:Cyclohexenes / Q000494:pharmacology; D004597:Electroshock; D002149:Energy Intake; D000431:Ethanol; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013312:Stress, Physiological; D013729:Terpenes / Q000494:pharmacology; D015431:Weight Loss
chemical_list: D053138:Cyclohexenes; D010936:Plant Extracts; D013729:Terpenes; D002338:Carotenoids; D000431:Ethanol; C087963:safranal; C029036:crocin; D003345:Corticosterone