title: Treatment of long bone non-unions with polytherapy: indications and clinical results.
abstract: The incidence of long bone non-unions has been estimated to range between 5 and 10%. Autologous bone graft usually harvested from the iliac crest continues to be the gold standard for biological enhancement of atrophic non-unions. However, its use has been hampered by minor and major donor site complications. Moreover despite possessing the properties of osteogenecity, osteoconductivity and some osteoinductivity the overall results of treatment have not been consistent with disappointing success rates at times. The concept of polytherapy for the treatment of non-unions, namely the simultaneous application of the three fundamental elements of the diamond concept, osteoprogenitor cells, growth factor and osteoconductive scaffold, appears to be an attractive alternative but more studies are desirable to validate this strategy.
authors.affiliation: COR, Orthopaedic Institute, G Pini, University of Milan, Milan, Italy. gmc@studiocalori.it
authors.forename: G M
authors.initials: GM
authors.lastname: Calori
authors.forename: E
authors.initials: E
authors.lastname: Mazza
authors.forename: M
authors.initials: M
authors.lastname: Colombo
authors.forename: C
authors.initials: C
authors.lastname: Ripamonti
authors.forename: L
authors.initials: L
authors.lastname: Tagliabue
mesh_terms: D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods; D017102:Fracture Healing / Q000502:physiology*; D005599:Fractures, Ununited / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D019485:Bone Morphogenetic Proteins