title: Electrolytic lesions of the bed nucleus of the stria terminalis disrupt freezing and startle potentiation in a conditioned context.
abstract: Expression of contextual anxiety in a previously shocked context is a widely used model of anxiety, with the main behavioral measures being freezing or startle amplitude. There is extensive evidence that the bed nucleus of the stria terminalis (BST) is involved in several anxiety paradigms, e.g., BST lesions disrupt contextual freezing. Surprisingly, studies investigating the effect on startle potentiation in a conditioned context are still lacking in the literature. In the present study, we found that post-training bilateral electrolytic lesions in the BST completely disrupted the expression of contextual anxiety, as quantified with combined measurements of startle amplitude and freezing.
authors.affiliation: Laboratory of Experimental Functional Neurosurgery, Department of Neurosciences, K.U. Leuven, Minderbroedersstraat 19 bus 1033, 3000 Leuven, Belgium. laura.luyten@med.kuleuven.be
authors.forename: Laura
authors.initials: L
authors.lastname: Luyten
authors.forename: Kris
authors.initials: K
authors.lastname: van Kuyck
authors.forename: Debora
authors.initials: D
authors.lastname: Vansteenwegen
authors.forename: Bart
authors.initials: B
authors.lastname: Nuttin
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D003213:Conditioning, Psychological / Q000502:physiology*; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods; D046352:Freezing Reaction, Cataleptic / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000502:physiology*; D012686:Septal Nuclei / Q000502:physiology*