title: Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326.
abstract: An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay system. The structure of 1 was determined in detail by NMR and circular dichroism spectroscopy, X-ray analysis, and chemical reaction experiments.
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea.
authors.forename: Jae-Hyuk
authors.initials: JH
authors.lastname: Jang
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Asami
authors.forename: Jun-Pil
authors.initials: JP
authors.lastname: Jang
authors.forename: Sun-Ok
authors.initials: SO
authors.lastname: Kim
authors.forename: Dong Oh
authors.initials: DO
authors.lastname: Moon
authors.forename: Kee-Sun
authors.initials: KS
authors.lastname: Shin
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hashizume
authors.forename: Makoto
authors.initials: M
authors.lastname: Muroi
authors.forename: Tamio
authors.initials: T
authors.lastname: Saito
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
authors.forename: Bo Yeon
authors.initials: BY
authors.lastname: Kim
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
authors.forename: Jong Seog
authors.initials: JS
authors.lastname: Ahn
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018267:Carcinoma, Acinar Cell / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D047630:Depsipeptides / Q000737:chemistry / Q000494:pharmacology*; D005670:Fusarium / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009361:Neoplasm Invasiveness
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides; C522435:fusaristatin A