title: Luminescence amplification strategies integrated with microparticle and nanoparticle platforms.
abstract: The amplification of luminescence signals is often the key to sensitive and powerful detection protocols. Besides optimized fluorescent probes and labels, functionalized nano- and microparticles have received strongly increasing attention in this context during the past decade. This contribution introduces the main signalling concepts for particle-based amplification strategies and stresses, especially the important role that metal and semiconductor nanoparticles play in this field. Besides resonance energy transfer, metal-enhanced emission and the catalytic generation of luminescence, the impact of multi-chromophoric objects such as dye nanocrystals, dendrimers, conjugated polymers or mesoporous hybrid materials is assessed. The representative examples discussed cover a broad range of analytes from metal ions and small organic molecules to oligonucleotides and enzyme activity.
authors.affiliation: Div I.5, BAM Bundesanstalt für Materialforschung und -prüfung, Richard-Willstätter-Str. 11, 12489, Berlin, Germany.
authors.forename: Shengchao
authors.initials: S
authors.lastname: Zhu
authors.forename: Tobias
authors.initials: T
authors.lastname: Fischer
authors.forename: Wei
authors.initials: W
authors.lastname: Wan
authors.forename: Ana B
authors.initials: AB
authors.lastname: Descalzo
authors.forename: Knut
authors.initials: K
authors.lastname: Rurack
mesh_terms: D002384:Catalysis; D050091:Dendrimers / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D008081:Liposomes; D049449:Luminescence; D053758:Nanoparticles / Q000737:chemistry*; D045663:Quantum Dots
chemical_list: D050091:Dendrimers; D008081:Liposomes; D006046:Gold