title: Xenotransplantation of breast cancers.
abstract: Three experimental systems based on mouse models are currently used to study breast cancer: transgenic mice, carcinogen-induced models, and xenografts of breast cancers. Each of these models has advantages and limitations. This chapter focuses on xenotransplantation of breast cancers and reviews the techniques used so far in establishing this model, the advantages and limitations compared to other experimental systems, and finally, the technical questions that remain to be answered.
authors.affiliation: Department of Research Oncology, School of Medicine, King’s College London, London, UK.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Cariati
authors.forename: Rebecca
authors.initials: R
authors.lastname: Marlow
authors.forename: Gabriela
authors.initials: G
authors.lastname: Dontu
mesh_terms: D000273:Adipose Tissue / Q000601:surgery; D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation / Q000379:methods*; D014183:Transplantation, Heterologous / Q000276:immunology / Q000379:methods*