title: [Hypertension and hypokalemia - a reninoma as the cause of suspected liquorice-induced arterial hypertension].
abstract: METHODS
  A 28-year-old woman presented with dizziness and arterial hypertension. She reported a daily intake of 300 mg liquorice.
  
  
  METHODS
  Laboratory analysis revealed hypokalaemia of 2.5 mmol/l and an elevated serum renin activity of 18.6 µg/l/h. Abdominal ultrasound and magnetic resonance imaging showed a circumscribed non-homogenuous round lesion (18 × 22 mm) in the upper third of the right kidney. Selective catheterization of the renal veins revealed increased renin activity in blood from the right renal vein, suggestive of a renin-producing tumor.
  
  
  METHODS
  Initially antihypertensive therapy with the direct renin receptor antagonist aliskiren was started and followed by a partial nephrectomy, which brought about adequate blood pressure and potassium levels.
  
  
  CONCLUSIONS
  The constellation of hypokalaemia and hypertension often leads to important causes of secondary hypertension such as primary hyperaldosteronism or renal artery stenosis. But less frequent causes should also be considered in the differential diagnoses, such as liquorice overindulgence or reninoma.
authors.affiliation: Zentrum für Innere Medizin, Sektion Endokrinologie und Diabetologie, Universitätsklinikum Hamburg-Eppendorf. cl.schulze-zur-wiesch@uke.uni-hamburg.de
authors.forename: C
authors.initials: C
authors.lastname: Schulze zur Wiesch
authors.forename: N
authors.initials: N
authors.lastname: Sauer
authors.forename: J
authors.initials: J
authors.lastname: Aberle
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006035:Glycyrrhiza / Q000633:toxicity*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D007008:Hypokalemia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D033162:Incidental Findings; D007606:Juxtaglomerular Apparatus / Q000473:pathology*; D007680:Kidney Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D056929:Liddle Syndrome / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D009392:Nephrectomy; D012083:Renin / Q000097:blood*; D014057:Tomography, X-Ray Computed
chemical_list: D012083:Renin