title: Iridoids from leaves of Gelsemium elegans.
abstract: Six iridoids, geleganoids, designated A-F, and five iridoid glycosides, geleganosides A and B together with three previously reported compounds, were isolated from leaves of Gelsemium elegans. Their structures were elucidated by spectroscopic and chemical analyses. The relative configuration of geleganoid A was confirmed by X-ray crystallographic diffraction analysis, and the absolute configuration of geleganoid B was determined by a modified Mosher's method. Selected compounds were evaluated for PC12 cell neurite outgrowth activity, but they were inactive.
authors.affiliation: The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Zhangjiang, Shanghai 201210, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, China.
authors.forename: Bin-Feng
authors.initials: BF
authors.lastname: Zhang
authors.affiliation: The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Zhangjiang, Shanghai 201210, China; Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China.
authors.forename: Qiu-Ping
authors.initials: QP
authors.lastname: Zhang
authors.affiliation: The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Zhangjiang, Shanghai 201210, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Liu
authors.affiliation: The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Zhangjiang, Shanghai 201210, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, China.
authors.forename: Gui-Xin
authors.initials: GX
authors.lastname: Chou
authors.affiliation: The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Zhangjiang, Shanghai 201210, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, China.
authors.forename: Zheng-Tao
authors.initials: ZT
authors.lastname: Wang
mesh_terms: D000818:Animals; D031450:Gelsemium / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D057889:Iridoid Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D016716:PC12 Cells; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats
chemical_list: D006027:Glycosides; D057889:Iridoid Glycosides