title: Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz.
abstract: Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I, atractylenolide II and atractylenolide III had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future.
authors.affiliation: Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Rd., Hangzhou 310003, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Jiang
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
mesh_terms: D047072:Aromatase Inhibitors / Q000494:pharmacology*; D031174:Atractylodes / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D047072:Aromatase Inhibitors; D010936:Plant Extracts