title: The influence of viral hepatitis status on long-term HCC outcome in patients with non-cirrhotic livers.
abstract: OBJECTIVE
  To evaluate the influence of viral hepatitis status on the long-term outcome of patients with hepatocellular carcinoma (HCC) in non-cirrhotic livers.
  
  
  METHODS
  Two hundred and seventy-nine patients diagnosed with HCC underwent liver resection. Histologic examination of the resected liver confirmed the absence of cirrhosis in 145 patients. Clinical characteristics and surgical outcome were compared between patients with HCC derived from non-cirrhotic liver with (n=111) and without (n=34) viral hepatitis.
  
  
  RESULTS
  One-, three- and five-year disease-specific survival rates in patients without viral markers (97.0%, 93.9% and 88.1%, respectively) were significantly higher than in patients with positive viral markers (97.2%, 81.0% and 62.3%, respectively) (p=0.0151). The five-year remnant liver recurrence-free survival rate in patients with negative viral markers (64.1%) was significantly higher than in patients with viral markers (44.9%) (p=0.0412).
  
  
  CONCLUSIONS
  Hepatic resection is beneficial for HCC in non-cirrhotic livers patients without viral hepatitis.
authors.affiliation: Yokohama City University Medical Center, Gastroenterological Center, 232-0024 4-57 Urafunecho, Minami-ku, Yokohama City, Japan. noji1192@yokohama-cu.ac.jp
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nojiri
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nagano
authors.forename: Kuniya
authors.initials: K
authors.lastname: Tanaka
authors.forename: Michio
authors.initials: M
authors.lastname: Ueda
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takeda
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kumamoto
authors.forename: Shouichi
authors.initials: S
authors.lastname: Fujii
authors.forename: Chikara
authors.initials: C
authors.lastname: Kunisaki
authors.forename: Itaru
authors.initials: I
authors.lastname: Endo
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology / Q000601:surgery / Q000821:virology*; D018572:Disease-Free Survival; D005260:Female; D006505:Hepatitis / Q000150:complications* / Q000821:virology; D006801:Humans; D007430:Intraoperative Care; D008099:Liver / Q000473:pathology* / Q000601:surgery / Q000821:virology; D008103:Liver Cirrhosis / Q000150:complications* / Q000821:virology; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome