title: Structure and cytotoxicity of phidianidines A and B: first finding of 1,2,4-oxadiazole system in a marine natural product.
abstract: Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidianidines exhibit high cytotoxicity against tumor and nontumor mammalian cell lines in in vitro assays.
authors.affiliation: Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Pozzuoli (Na), Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Carbone
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Carlo
authors.initials: C
authors.lastname: Irace
authors.forename: Ernesto
authors.initials: E
authors.lastname: Mollo
authors.forename: Francesco
authors.initials: F
authors.lastname: Castelluccio
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Pascale
authors.forename: Guido
authors.initials: G
authors.lastname: Cimino
authors.forename: Rita
authors.initials: R
authors.lastname: Santamaria
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
authors.forename: Margherita
authors.initials: M
authors.lastname: Gavagnin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D008974:Mollusca / Q000737:chemistry*; D010069:Oxadiazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D026121:Indole Alkaloids; D010069:Oxadiazoles; C559224:phidianidine A; C559225:phidianidine B