title: Esophageal cancer surgery in patients older than 75: long term results.
abstract: OBJECTIVE
  The purpose of this study was to evaluate short and long term results after esophageal cancer resection in patients older than 75.
  
  
  METHODS
  We retrospectively analyzed the database of esophageal cancer surgically treated in our department between January 2003 and December 2009 to identify patients older than 75. The preoperative, operative, postoperative and long term characteristics were analyzed.
  
  
  RESULTS
  Among 137 patient, 23 were older than 75. The histological subtype was adenocarcinoma in 100%. The surgical techniques were a "Lewis-Santy" procedure in 43%, a trans-hiatal resection in 22%, a "Sweet" procedure in 13%, a stripping in 13% and a McKeown procedure in 9%. The in-hospital postoperative mortality was 13%. The in-hospital postoperative morbidity (Dindo-Clavien Grade >2, deceased patients included) was 26%. In univariate analysis, no statistically significant risk factor of morbidity was found. A Charlson Comorbidity Index >2 was, in univariate analysis, the sole risk factor of postoperative mortality (p = 0.0362). The mean hospital stay was 22 +/- 12 days. The median survival was 24.2 months. The 5-year overall survival was 39% and the 5-year disease free survival was 26%.57% of long-term deaths were not cancer related.
  
  
  CONCLUSIONS
  Esophageal surgery performed in selected patients older than 75 has an acceptable morbidity and mortality but when a severe complication occurs, it leads to death in half of the cases. Surgery enables a long term survival benefit. This study confirmed our attitude of not considering age as a contra-indication for esophageal surgery but rather considering general status, self-reliance and associated comorbidities for patients' selection.
authors.affiliation: Abdominal, Senologic, Endocrine and Transplantation Surgery Department, CHU Liege. chhonore@hotmail.com
authors.forename: Ch
authors.initials: Ch
authors.lastname: Honoré
authors.forename: A
authors.initials: A
authors.lastname: Al-Azzeh
authors.forename: N
authors.initials: N
authors.lastname: Gilson
authors.forename: D
authors.initials: D
authors.lastname: Van Daele
authors.forename: M
authors.initials: M
authors.lastname: Polus
authors.forename: M
authors.initials: M
authors.lastname: Meurisse
authors.forename: A
authors.initials: A
authors.lastname: De Roover
authors.forename: P
authors.initials: P
authors.lastname: Honoré
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000075202:Contraindications; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods; D005260:Female; D006801:Humans; D007902:Length of Stay; D012189:Retrospective Studies; D016896:Treatment Outcome