title: A case of refractory pyoderma gangrenosum treated with a combination of Apligraf and systemic immunosuppressive agents.
abstract: Pyoderma gangrenosum (PG) is a rare inflammatory ulcerative skin disease. A case of refractory PG treated with a combination of immunosuppression and Apligraf (Organogenesis, Canton, Massachusetts) is presented. Under infliximab, systemic corticosteroids, and Apligraf, the wound showed a slow but complete healing. The authors demonstrated the potential benefits of Apligraf in the healing of PG.
authors.affiliation: Department of Dermatology, University Hospital Basel, Basel, Switzerland.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Duchini
authors.forename: Peter
authors.initials: P
authors.lastname: Itin
authors.forename: Andreas
authors.initials: A
authors.lastname: Arnold
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D000069285:Infliximab; D055985:Latent Tuberculosis / Q000188:drug therapy; D008297:Male; D017511:Pyoderma Gangrenosum / Q000188:drug therapy*; D017211:Treatment Failure; D014945:Wound Healing; D014947:Wounds and Injuries / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; C117898:Apligraf; D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D003094:Collagen; D000069285:Infliximab