title: Gender differences in patients undergoing coronary stenting in current stent era.
abstract: BACKGROUND
  Prior studies have demonstrated worse results of women in both hospital and short-term outcomes post-percutaneous coronary intervention. However, with advanced devices like drug-eluting stents (DESs) available, there are no consistent data revealing gender impact in outcome. This study examined whether gender affected hospital outcome and showed one-year single-center patient results of coronary stenting.
  
  
  METHODS
  The study group included 969 consecutive patients (250 women and 719 men) undergoing coronary stenting for stable or unstable angina. Clinical events were assessed for at least 1 year post-procedure.
  
  
  RESULTS
  Compared to men, women were older, presented more often with diabetes, hypertension, dyslipidemia, and lower creatinine clearance rate (Ccr); they had less percutaneous transluminal coronary angioplasty (PTCA) history, smaller vessel size, and shorter lesions. The hospital major adverse cardiovascular event (MACE) rate was 2.8% of women and 0.97% of men (P = 0.037). The one-year MACE rate was 10.0% of women and 10.4% of men (P = 0.874). After adjusting other covariates, women still had significantly higher hospital MACE rates (P = 0.034) and odds ratios (0.18; 95% confidence interval: 0.036-0.874). In women (n = 250), there was no statistically significant difference in hospital or one-year MACE between bare metal stent (BMS) and DES groups. Meanwhile, in men (n = 719), DES had a significant one-year improvement of MACE compared to BMS (P = 0.004). The female hospital MACE rate was five times greater than male results. However, there were similar one-year outcomes between women and men. DES currently have an advantage in long-term outcome.
  
  
  CONCLUSIONS
  Currently, with the use of BMS and DES, adverse hospital post-procedure cardiovascular event rate has occurred more often in women than in men. However, the MACE rate differences between women and men resolved with one year follow-up.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Taiwan, China.
authors.forename: Max
authors.initials: M
authors.lastname: Woo
authors.forename: Chang-qing
authors.initials: CQ
authors.lastname: Fan
authors.forename: Yung-Lung
authors.initials: YL
authors.lastname: Chen
authors.forename: Hesham
authors.initials: H
authors.lastname: Husein
authors.forename: Hsiu-Yu
authors.initials: HY
authors.lastname: Fang
authors.forename: Cheng-Jui
authors.initials: CJ
authors.lastname: Lin
authors.forename: Chiung-Jen
authors.initials: CJ
authors.lastname: Wu
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000628:therapy; D000789:Angina, Unstable / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D016896:Treatment Outcome