title: A pilot study of normative data for macular thickness and volume measurements using cirrus high-definition optical coherence tomography.
abstract: OBJECTIVE
  To establish preliminary normative data for macular thickness (MT) and macular volume (MV) by Cirrus high-definition optical coherence tomography (Carl Zeiss Meditec, Dublin, CA).
  
  
  METHODS
  Retrospective case series of 192 eyes of 192 subjects (age, 20-90 years) without retinal disease or surgery with best-corrected visual acuity ≥ 20/25, intraocular pressure <21 mmHg, and cup-to-disc ratio ≤ 0.5 were enrolled. Retinal thicknesses in nine Early Treatment Diabetic Retinopathy Study subfields (including central subfield thickness [CST]), MT, and MV were measured with Cirrus high-definition optical coherence tomography. Effects of age, gender, lens status, and diabetic status on these measurements were analyzed.
  
  
  RESULTS
  The mean ± SD CST, MT, and MV were 262.4 ± 22.8 μm, 281.3 ± 14.5 μm, and 10.1 ± 0.6 mm3, respectively. Although CST and age were not associated (P = 0.45), both mean MT and mean MV declined with age (P < 0.0001). Central subfield thickness (P = 0.002), mean MT (P = 0.021), and MV (P = 0.041) were higher in men compared with women. Neither lens status nor diabetic status affected CST, MT, or MV.
  
  
  CONCLUSIONS
  A pilot study showed that preliminary normative CST, MT, and MV values were obtained by Cirrus high-definition optical coherence tomography. The authors propose that CST ranges from 216.8 μm to 308 μm in normal eyes. Older age and female gender were associated with thinner MT.
authors.affiliation: Retina Division, Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095-7000, USA.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Liu
authors.forename: Allen Y
authors.initials: AY
authors.lastname: Hu
authors.forename: Andrew
authors.initials: A
authors.lastname: Kaines
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.forename: Steven D
authors.initials: SD
authors.lastname: Schwartz
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hubschman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012016:Reference Values; D012160:Retina / Q000033:anatomy & histology*; D012189:Retrospective Studies; D012737:Sex Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult