title: Nominal association between a polymorphism in DGKH and bipolar disorder detected in a meta-analysis of East Asian case-control samples.
abstract: OBJECTIVE
  Recent genome-wide association studies (GWAS) of bipolar disorder (BD) have detected new candidate genes, including DGKH, DFNB31 and SORCS2. However, the results of these GWAS were not necessarily consistent, indicating the importance of replication studies. In this study, we tested the genetic association of DGKH, DFNB31 and SORCS2 with BD.
  
  
  METHODS
  We genotyped 18 single-nucleotide polymorphisms (SNP) in DGKH, DFNB31 and SORCS2 using Japanese samples (366 cases and 370 controls). We also performed a meta-analysis of four SNP in DGKH, using the previously published allele frequency data of Han-Chinese case-control samples (1139 cases and 1138 controls).
  
  
  RESULTS
  IN the association analysis using Japanese samples, a SNP in SORCS2 (rs10937823) showed nominal genotypic association. However, we could not find any association in an additional analysis of tag SNP around rs10937823. In the meta-analysis of SNP in DGKH, rs9315897, which was not significantly associated with BD in the previous Chinese study, showed nominal association.
  
  
  CONCLUSIONS
  Although the association was not strong, the result of this study would support the association between DGKH and BD.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takata
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Iwayama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamada
authors.forename: Leo
authors.initials: L
authors.lastname: Gotoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitsuyasu
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miura
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
authors.forename: Takeo
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Kanba
mesh_terms: D044466:Asian People / Q000235:genetics; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D019852:Diacylglycerol Kinase / Q000235:genetics*; D005202:Asia, Eastern; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics
chemical_list: D008565:Membrane Proteins; D011956:Receptors, Cell Surface; C509461:SORCS2 protein, human; C477219:WHRN protein, human; D019852:Diacylglycerol Kinase