title: Influence of preinfarction angina on the release kinetics of endothelial progenitor cells and cytokines during the week after infarction.
abstract: BACKGROUND
  Preinfarction angina, a possible form of ischaemic preconditioning, improves the prognosis in patients who experience a major ischaemic event; though the associated pathophysiology is not yet fully understood. The aim of this study was to determine the possible involvement of endothelial progenitor cells (EPC), the vascular endothelial growth factor (VEGF) and the hepatocyte growth factor (HGF) in the development of preinfarction angina.
  
  
  RESULTS
  We studied 41 patients (60·5 ± 12 years; 34% women) and 14 healthy controls; 43·9% of the patients had preinfarction angina. No differences were found in the baseline characteristics of the two groups. Although the EPC, VEGF and HGF were raised as compared with the control group, no significant differences were found according to the presence or absence of preinfarction angina in the levels of EPC (baseline, P = 0·25; day 3, P = 0·11; day 7, P = 0·32), VEGF (baseline, P = 0·96; day 3, P = 0·06; day 7, P = 0·57) or HGF (baseline, P = 0·18; day 3, P = 1; day 7, P = 0·86). An association was seen in the patients who had preinfarction angina between the EPC levels at baseline and on days 3 and 7 and the HGF on admission with the time from the angina to the STEMI (β = -0·070; β = -0·066; β = -0·081; β = -80·16; P < 0·05), showing a reduction in the level of EPC cells for each hour passed since the event.
  
  
  CONCLUSIONS
  No differences were found in the release kinetics of EPC, VEGF or HGF after a first infarction according to whether the patients had angina during the week before the infarction.
authors.affiliation: Área del Corazón, Hospital Clínico Universitario Virgen de la Victoria de Malaga, Campus de Teatinos, Malaga, Spain. jimeneznavarro@secardiologia.es
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Jiménez-Navarro
authors.forename: Juan
authors.initials: J
authors.lastname: Caballero-Borrego
authors.forename: Noela
authors.initials: N
authors.lastname: Rodriguez-Losada
authors.forename: Fernando
authors.initials: F
authors.lastname: Cabrera-Bueno
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Marchal
authors.forename: Javier
authors.initials: J
authors.lastname: Estebaranz
authors.forename: Antonio
authors.initials: A
authors.lastname: Muñoz-García
authors.forename: Macarena
authors.initials: M
authors.lastname: Perán
authors.forename: Rita
authors.initials: R
authors.lastname: Pérez
authors.forename: Gemma
authors.initials: G
authors.lastname: Ramírez
authors.forename: José M
authors.initials: JM
authors.lastname: Hernández-García
authors.forename: Antonia
authors.initials: A
authors.lastname: Aránega
authors.forename: Eduardo
authors.initials: E
authors.lastname: de Teresa Galván
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000503:physiopathology*; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000378:metabolism*; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D016130:Immunophenotyping; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D013223:Statistics as Topic; D013234:Stem Cells / Q000378:metabolism*; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D017228:Hepatocyte Growth Factor