title: Evaluation of Lysimachia christinae Hance extracts as anticholecystitis and cholagogic agents in animals.
abstract: BACKGROUND
  Lysimachia christinae Hance is one of the herbs commonly used in traditional Chinese medicine for the treatment of cholecystitis and cholagogic efficiency.
  
  
  OBJECTIVE
  The water extract of Lysimachia christinae Hance was investigated to see if it possesses cholecystitis and cholagogic effects through traditional pathways.
  
  
  METHODS
  Lithocholic acid (LCA) and Escherichia coli were used to induce cholecystitis in adult guinea pigs. The present study evaluated the cholagogic effects of LCHE treatment on bile secretion and bile emptying in Sprague-Dawley rats and male Kunming mice.
  
  
  RESULTS
  The results showed that LCHE not only produced excellent anticholecystitis effects but also improved lesion severity in gallbladders induced by LCA. Similarly, LCHE administered to animals in the high-dose group exhibited an antibacterial effect in acute cholecystitis, and treatment with a mid-range or a high dose of LCHE resulted in an antipyretic effect, however, three doses of LCHE treatment groups had no effect on pathological change induced by Escherichia coli in gallbladder. Treatment with a high dose of LCHE significantly promoted bile secretion (0-90min, P<0.01), and treatment with a mid-range dose also significantly promoted bile secretion (30-60min P<0.05). Furthermore, treatment with a high dose of LCHE significantly promoted bile emptying (P<0.01).
  
  
  CONCLUSIONS
  Our results demonstrate that LCHE exhibits a marked anticholecystitis and cholagogic activity in animals, which supports previous claims of its use in traditional Chinese medicine.
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400044, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Yang
authors.forename: Bo-Chu
authors.initials: BC
authors.lastname: Wang
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.forename: Wei-Qi
authors.initials: WQ
authors.lastname: Liu
authors.forename: Jun-Zhen
authors.initials: JZ
authors.lastname: Qian
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Jia
authors.initials: J
authors.lastname: Deng
authors.forename: Gurinder K
authors.initials: GK
authors.lastname: Singh
authors.forename: Hui
authors.initials: H
authors.lastname: Su
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D001659:Biliary Tract / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D002764:Cholecystitis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004926:Escherichia coli; D005260:Female; D006168:Guinea Pigs; D008095:Lithocholic Acid; D008297:Male; D051379:Mice; D029623:Primulaceae; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D002756:Cholagogues and Choleretics; D004365:Drugs, Chinese Herbal; D008095:Lithocholic Acid