title: Evidence that the marine-derived multi-mineral Aquamin has anti-inflammatory effects on cortical glial-enriched cultures.
abstract: It is well established that neuroinflammation contributes to brain aging, and that cortical cells are particularly vulnerable. Lipopolysaccharide stimulates the release of the pro-inflammatory cytokines, tumor necrosis factor-alpha and interleukin-1beta from glial cells which consequently induces an impairment in neuronal cell function. The food supplement, Aquamin, is a natural, multi-mineral derived from the red algae Lithothamnion corallioides, rich in calcium, magnesium and 72 other trace minerals. The aim of this study was to evaluate the anti-inflammatory potential of Aquamin in lipopolysaccharide-stimulated, glial-enriched primary cultures of rat cortex. It is reported that Aquamin prevented lipopolysaccharide-induced secretion of tumor necrosis factor-alpha and interleukin-1beta from cortical glia. These data suggest that nutritional supplements such as Aquamin may play an important role in impeding the detrimental effects of excessive inflammation in the brain.
authors.affiliation: Department of Anatomy and Neuroscience, University College Cork, Ireland.
authors.forename: Sinead
authors.initials: S
authors.lastname: Ryan
authors.forename: Denise M
authors.initials: DM
authors.lastname: O'Gorman
authors.forename: Yvonne M
authors.initials: YM
authors.lastname: Nolan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology*; D019587:Dietary Supplements; D007249:Inflammation / Q000188:drug therapy*; D053583:Interleukin-1beta / Q000187:drug effects; D008070:Lipopolysaccharides / Q000494:pharmacology; D008903:Minerals / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D009457:Neuroglia / Q000187:drug effects*; D008517:Phytotherapy; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000461:Rhodophyta / Q000737:chemistry*; D012624:Seaweed; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; C572820:Aquamin; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D008903:Minerals; D028321:Plant Preparations; D014409:Tumor Necrosis Factor-alpha