title: Comparative efficacy of inhaled albuterol between two hand-held delivery devices in horses with recurrent airway obstruction.
abstract: BACKGROUND
  Studies investigating the clinical efficacy of albuterol administered with the same propellant and commercially available delivery devices in horses with recurrent airway obstruction (RAO) are not currently available.
  
  
  OBJECTIVE
  To determine the efficacy of aerosolised albuterol administered to horses with RAO by means of 2 commercially available, hand-held delivery devices.
  
  
  METHODS
  Ten horses with RAO were kept in a dusty environment and fed mouldy hay to induce airway obstruction. Lung mechanics were measured before and after the procedure. ΔP(max) was measured 5 min after administration of 180 µg of albuterol from a pressurised metered dose inhaler, using an aerosol delivery device chosen randomly. This process was repeated every 5 min until maximal bronchodilation was achieved. After a 24 h washout period, lung mechanics data were again collected using the other aerosol delivery device.
  
  
  RESULTS
  Aerosolised albuterol induced a significant and rapid bronchodilation in the horses using both aerosol delivery devices. No statistically significant difference in pulmonary function was observed in response to albuterol therapy between the 2 devices. The dose required to achieve 50% of maximal bronchodilation was not statistically different between the 2 devices (173.35 ± 78.35 µg with Device 1 and 228.49 ± 144.99 µg with Device 2, P = 0.26). The decrease in lung resistance tended to be more pronounced after albuterol administration with Device 1 (P = 0.066).
  
  
  CONCLUSIONS
  Aerosolised albuterol is an effective bronchodilator in horses with recurrent airway obstruction. There is no statistically significant difference between the 2 commercially available aerosol delivery devices in terms of efficacy.
  
  
  CONCLUSIONS
  Aerosolised albuterol is effectively delivered using currently available devices leading to maximal bronchodilation in horses with RAO at an average dose of 540 µg.
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, Indiana, USA.
authors.forename: F R
authors.initials: FR
authors.lastname: Bertin
authors.forename: K M
authors.initials: KM
authors.lastname: Ivester
authors.forename: L L
authors.initials: LL
authors.lastname: Couëtil
mesh_terms: D000280:Administration, Inhalation; D000402:Airway Obstruction / Q000188:drug therapy / Q000662:veterinary*; D000420:Albuterol / Q000008:administration & dosage*; D000818:Animals; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008297:Male; D036501:Metered Dose Inhalers / Q000592:standards / Q000662:veterinary*; D012129:Respiratory Function Tests / Q000662:veterinary; D018709:Statistics, Nonparametric
chemical_list: D001993:Bronchodilator Agents; D000420:Albuterol