title: Overview on platelet preservation: better controls over storage lesion.
abstract: Platelet storage lesion (PSL), correlating with reduced in vivo recovery/survival and hemostatic capacity after transfusion, is characterized essentially by morphological and molecular evidence of platelet activation and energy consumption in the medium. Processes that limit shelf-life are multifactorial, and include both necrosis and apoptosis. PSL is greatly influenced by factors including duration of storage, temperature, ratio of platelet number to media volume, solution composition with respect to energy content and buffering capacity, and gas permeability of the container. Recent progress for slowing PSL has been made with storage media that more effectively fuel ATP production and buffer the inevitable effects of metabolism. Improved oxygen-permeability of containers also helps to maintain aerobic-dominant glycolysis. Patients stand to benefit from platelet products of higher intrinsic quality that store well until the moment of transfusion.
authors.affiliation: Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan. hit-ohto@fmu.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohto
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Nollet
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001792:Blood Platelets / Q000166:cytology* / Q000378:metabolism*; D001793:Blood Preservation / Q000379:methods*; D006801:Humans; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D017713:Platelet Transfusion; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D011310:Preservatives, Pharmaceutical; D000255:Adenosine Triphosphate; D010100:Oxygen