title: Three new oblongolides from Phomopsis sp. XZ-01, an endophytic fungus from Camptotheca acuminate.
abstract: Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds--oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12)--were isolated from the endophytic fungal strain Phomopsis sp. XZ-01 of Camptotheca acuminate. Their structures were elucidated by spectroscopic analyses, including 1H- and 13C-NMR, 2D NMR (HSQC, HMBC, 1H-1H COSY and NOESY) and HR-FT-MS. Cytotoxic activities of these compounds were evaluated. Some of them showed weak selective activities.
authors.affiliation: School of Pharmaceutical Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China. linting@xmu.edu.cn
authors.forename: Ting
authors.initials: T
authors.lastname: Lin
authors.forename: Guang Hui
authors.initials: GH
authors.lastname: Wang
authors.forename: Xiang
authors.initials: X
authors.lastname: Lin
authors.forename: Zhi Yu
authors.initials: ZY
authors.lastname: Hu
authors.forename: Quan Cheng
authors.initials: QC
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.forename: Xiao Kun
authors.initials: XK
authors.lastname: Zhang
authors.forename: Hai Feng
authors.initials: HF
authors.lastname: Chen
mesh_terms: D029769:Camptotheca / Q000737:chemistry*; D005583:Fourier Analysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry