title: Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole.
abstract: A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Yang
authors.forename: Xue-Quan
authors.initials: XQ
authors.lastname: Wang
authors.forename: Gao-Lan
authors.initials: GL
authors.lastname: Zhang
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; D007093:Imidazoles