title: [Balance of proteinases and antiproteinases and smoking tobacco].
abstract: Smoking tobacco can induce formation of inflammable state in respiratory tract and cause lungs damage. Experimental investigations affirm, that the exposure to tobacco smoke causes growth of penetrability of blood-vessels, which favors the enlarged migration of inflammable cells. The growth of exposure to reactive forms of oxygen and concentration changes of cellular antioxidants enzymes, leads to disorders in balance of proteinases and antiproteinases and oxidative stress. As the years go, the disorders mentioned above can lead to deterioration of ventilating efficiency of lungs, and consequently to pronouncement chronic obstructive pulmonary disease (COPD), which becomes serious problem on a world scale.
authors.affiliation: Katedra i Klinika Alergologii, Immunologii Klinicznej i Chorób Wewnętrznych, Collegium Medicum w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu. joannak555@wp.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Kołodziejczyk
authors.forename: Milena
authors.initials: M
authors.lastname: Wojciechowska
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Bartuzi
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dziedziczko
mesh_terms: D006801:Humans; D018384:Oxidative Stress; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology*; D012907:Smoking
chemical_list: D011480:Protease Inhibitors; D010447:Peptide Hydrolases