title: [Progress of polymorphism in microRNA and microRNA target sites].
abstract: MicroRNAs (miRNAs), which are evolutionarily well-conserved, 21- to 23-nucleotide-long, small non-coding RNAs, are widely involved in the regulation of multiple biological processes, such as development, organogenesis, cell proliferation, cell differentiation, and apoptosis. Recent studies have shown that polymorphism in miRNAs and their target sites are closely related to various diseases, such as tumor and cardiological diseases. This review introduces recent progresses on polymorphism in microRNAs and their targeting sites and the related diseases.
authors.affiliation: Key Laboratory of Environment and Genes Related to Diseases Ministry of Education, the Central Laboratory for Biomedical Research, Medical School, Xi'an Jiaotong University, Xi 'an 710061, China. llying@mail.xjtu.edu.cn
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Liu
authors.forename: Ji-Ru
authors.initials: JR
authors.lastname: Xu
authors.forename: Tu-Sheng
authors.initials: TS
authors.lastname: Song
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
mesh_terms: D019175:DNA Methylation; D004194:Disease / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D009154:Mutation; D011110:Polymorphism, Genetic
chemical_list: D035683:MicroRNAs