title: Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: a randomized controlled clinical trial.
abstract: BACKGROUND
  Platelet-rich fibrin (PRF) is considered a second-generation platelet concentrate that is widely used in osseous regeneration. The present study aims to explore the clinical and radiographic effectiveness of autologous PRF in the treatment of intrabony defects in patients with chronic periodontitis.
  
  
  METHODS
  Fifty-six intrabony defects were treated with either autologous PRF with open-flap debridement or open-flap debridement alone. Clinical parameters such as the probing depth (PD) and periodontal attachment level (PAL) were recorded at baseline and 9 months postoperatively. The defect fill at baseline and 9 months was calculated on standardized radiographs by using image-analysis software.
  
  
  RESULTS
  The mean PD reduction was greater in the test group (4.55 ± 1.87 mm) than in the control group (3.21 ± 1.64 mm), whereas the mean PAL gain was also greater in the test group (3.31 ± 1.76) compared to the control group (2.77 ± 1.44 mm). Furthermore, a significantly greater percentage of mean bone fill was found in the test group (48.26% ± 5.72%) compared to the control group (1.80% ± 1.56%).
  
  
  CONCLUSIONS
  Within the limits of the present study, there was greater PD reduction, PAL gain, and bone fill at sites treated with PRF with conventional open-flap debridement compared to conventional open-flap debridement alone. However, a long-term, multicentered randomized controlled clinical trial is required to know the clinical and radiographic effects of PRF on bone regeneration.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
authors.forename: Anuj
authors.initials: A
authors.lastname: Sharma
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D001792:Blood Platelets; D001861:Bone Regeneration; D016009:Chi-Square Distribution; D055113:Chronic Periodontitis / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D011446:Prospective Studies; D011859:Radiography
chemical_list: D005337:Fibrin