title: Methotrexate in local treatment of cervical heterotopic pregnancy with successful perinatal outcome: case report.
abstract: This case report describes a case of heterotopic cervical ectopic pregnancy in a nulliparous woman that was successfully treated with single-dose local, intra-amniotic methotrexate injection in the gestational sac. Pregnancy was achieved spontaneously. The patient had previously undergone hysteroscopic myomectomy. By using local, single-dose treatment we avoided the continued effects of the drug on the intrauterine pregnancy and the possible adverse effect of systemically applied methotrexate. The treatment resulted in the term vaginal delivery of a healthy child and preserved the patient's fertility for future pregnancies.
authors.affiliation: Department of Minimally Invasive Gynecology, University Hospital Osijek, J. Huttlera 4, Osijek, Croatia. d-vidosavljevic@inet.hr
authors.forename: Sinisa
authors.initials: S
authors.lastname: Sijanovic
authors.forename: Domagoj
authors.initials: D
authors.lastname: Vidosavljevic
authors.forename: Ivanka
authors.initials: I
authors.lastname: Sijanovic
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000328:Adult; D000650:Amnion; D002584:Cervix Uteri / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007267:Injections; D050498:Live Birth; D008727:Methotrexate / Q000008:administration & dosage*; D011247:Pregnancy; D018607:Pregnancy Reduction, Multifetal / Q000379:methods*; D011261:Pregnancy Trimester, First; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000628:therapy*; D016216:Ultrasonography, Prenatal
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate