title: "One-pot" multicomponent approach to indolizines and pyrido[1,2-a]indoles.
abstract: A new synthetic protocol for efficient and regiospecifc assembly of indolizines and pyrido[1,2-a]indoles by coupling of substituted methyl bromides and alkynes with corresponding pyrrole-2-carboxaldehyde and 1H-indole-2-carboxaldehyde has been developed. Additionally, a possible mechanism for the reaction is proposed.
authors.affiliation: Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P R China.
authors.forename: Huajian
authors.initials: H
authors.lastname: Zhu
authors.forename: Joachim
authors.initials: J
authors.lastname: Stöckigt
authors.forename: Yongping
authors.initials: Y
authors.lastname: Yu
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zou
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D006842:Hydrocarbons, Brominated; D007211:Indoles; D007212:Indolizines; D011758:Pyrroles; C051266:pyrrole-2-carboxaldehyde