title: General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance.
abstract: BACKGROUND
  Cognitive control impairments in schizophrenia are thought to arise from dysfunction of interconnected networks of brain regions, but interrogating the functional dynamics of large-scale brain networks during cognitive task performance has proved difficult. We used functional magnetic resonance imaging to generate event-related whole-brain functional connectivity networks in participants with first-episode schizophrenia and healthy control subjects performing a cognitive control task.
  
  
  METHODS
  Functional connectivity during cognitive control performance was assessed between each pair of 78 brain regions in 23 patients and 25 control subjects. Network properties examined were region-wise connectivity, edge-wise connectivity, global path length, clustering, small-worldness, global efficiency, and local efficiency.
  
  
  RESULTS
  Patients showed widespread functional connectivity deficits in a large-scale network of brain regions, which primarily affected connectivity between frontal cortex and posterior regions and occurred irrespective of task context. A more circumscribed and task-specific connectivity impairment in frontoparietal systems related to cognitive control was also apparent. Global properties of network topology in patients were relatively intact.
  
  
  CONCLUSIONS
  The first episode of schizophrenia is associated with a generalized connectivity impairment affecting most brain regions but that is particularly pronounced for frontal cortex. Superimposed on this generalized deficit, patients show more specific cognitive-control-related functional connectivity reductions in frontoparietal regions. These connectivity deficits occur in the context of relatively preserved global network organization.
authors.affiliation: Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK. ornitoa@unimelb.edu.au
authors.forename: Alex
authors.initials: A
authors.lastname: Fornito
authors.forename: Jong
authors.initials: J
authors.lastname: Yoon
authors.forename: Andrew
authors.initials: A
authors.lastname: Zalesky
authors.forename: Edward T
authors.initials: ET
authors.lastname: Bullmore
authors.forename: Cameron S
authors.initials: CS
authors.lastname: Carter
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology*; D010296:Parietal Lobe / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*; D012565:Schizophrenic Psychology