title: Expression of cytokeratins in the epithelium of canine odontogenic tumours.
abstract: Odontogenic tumours are considered to be relatively rare; however, several histologically distinct types have been identified in dogs. The more common canine odontogenic tumours are peripheral odontogenic fibroma and canine acanthomatous ameloblastoma. The expression of cytokeratins (CKs) has been established for the human dental germ and odontogenic tumours. The aim of the present study was to describe the immunohistochemical expression of a panel of CKs in the epithelium of the canine dental germ, normal gingiva and odontogenic tumours arising in this species. Samples from 20 odontogenic tumours, 12 tooth germs and three normal gingival tissues were obtained. Each sample was stained with haematoxylin and eosin and subjected to immunohistochemistry for CK expression. The typical expression pattern of CKs in the odontogenic epithelium and gingiva of dogs was CK14 and CK5/6. CKs 7, 8, 18 and 20 were generally absent from the canine dental germ, gingiva and odontogenic tumours. Dogs and man therefore exhibit similar CK expression in the odontogenic epithelium.
authors.affiliation: William R. Pritchard Veterinary Medical Teaching Hospital, USA. University of California, Davis, CA 95616, USA.
authors.forename: B
authors.initials: B
authors.lastname: Arzi
authors.forename: B
authors.initials: B
authors.lastname: Murphy
authors.forename: A
authors.initials: A
authors.lastname: Nemec
authors.forename: N
authors.initials: N
authors.lastname: Vapniarsky
authors.forename: D K
authors.initials: DK
authors.lastname: Naydan
authors.forename: F J M
authors.initials: FJ
authors.lastname: Verstraete
mesh_terms: D000564:Ameloblastoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D000818:Animals; D002454:Cell Differentiation; D004283:Dog Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D004848:Epithelium / Q000378:metabolism*; D005350:Fibroma / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D015972:Gene Expression Regulation, Neoplastic; D005881:Gingiva / Q000378:metabolism; D005887:Gingival Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D007382:Intermediate Filaments / Q000378:metabolism; D007633:Keratins / Q000096:biosynthesis* / Q000235:genetics; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009808:Odontogenic Tumors / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D009810:Odontoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D014083:Tooth Germ / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; D007633:Keratins