title: Macrocyclic chelator assembled RGD multimers for tumor targeting.
abstract: Macrocyclic chelators have been extensively used for complexation of metal ions. A widely used chelator, DOTA, has been explored as a molecular platform to assemble multiple bioactive peptides in this paper. The multivalent DOTA-peptide bioconjugates demonstrate promising tumor targeting ability.
authors.affiliation: Molecular Imaging Program at Stanford, Department of Radiology, Stanford University Medical Center, California 94305, USA.
authors.forename: Xiaofen
authors.initials: X
authors.lastname: Zhang
authors.forename: Hongguang
authors.initials: H
authors.lastname: Liu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Miao
authors.forename: Richard
authors.initials: R
authors.lastname: Kimura
authors.forename: Feiyue
authors.initials: F
authors.lastname: Fan
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000737:chemistry*; D003952:Diagnostic Imaging; D016503:Drug Delivery Systems; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D009842:Oligopeptides / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D002614:Chelating Agents; D006573:Heterocyclic Compounds, 1-Ring; D047028:Macrocyclic Compounds; D009842:Oligopeptides; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; C047981:arginyl-glycyl-aspartic acid