title: Two case reports of Clostridium difficile bacteremia, one with the epidemic NAP-1 strain.
abstract: Clostridium difficile bacteremia is rare. Here, we report two cases of C. difficile bacteremia in patients with significant underlying gastrointestinal pathology. In one case, the bacteremia was caused by the North American pulsed-field gel electrophoresis (PFGE) type 1 (NAP-1) strain, which is responsible for recent outbreaks of C. difficile infections of increased severity.
authors.affiliation: Clinical Microbiology, Department of Pathology, The Ohio State University Medical Center, University Hospitals East, 1492 E. Broad Street, Columbus, OH 43205, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hemminger
authors.forename: J-M
authors.initials: JM
authors.lastname: Balada-Llasat
authors.forename: M
authors.initials: M
authors.lastname: Raczkowski
authors.forename: M
authors.initials: M
authors.lastname: Buckosh
authors.forename: P
authors.initials: P
authors.lastname: Pancholi
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000583:Amikacin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D016360:Clostridioides difficile / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D015897:Comorbidity; D006801:Humans; D008297:Male; D009820:Ohio; D016896:Treatment Outcome; D014640:Vancomycin / Q000627:therapeutic use; D047090:beta-Lactams / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D014640:Vancomycin; D000583:Amikacin