title: Prooxidant-antioxidant balance in stroke patients and 6-month prognosis.
abstract: BACKGROUND
  Oxidative stress is thought to play an important role in the pathogenesis of stroke.
  
  
  METHODS
  In the present study, we assessed the extent of oxidative stress in the sera of 120 patients in the first 24 hours after the onset of stroke and 80 healthy control subjects using a novel assay of prooxidant-antioxidant balance (PAB) that can measure the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby giving a redox index.
  
  
  RESULTS
  In stroke patients median serum PAB values were significantly higher than that of the control group [125.50 (103.36 - 151.80) vs 43.40 (29.77 - 77.01), p < 0.001]. However, no significant difference was observed between subgroups of patients with transient ischemic attack (TIA), cerebral infarction or cerebral hemorrhage (p > 0.05). Median Serum PAB values were not significantly different in patients with different outcomes based on their 6-month prognosis (p > 0.05).
  
  
  CONCLUSIONS
  We conclude that serum PAB values are elevated in patients with stroke, indicating a heightened state of oxidative stress, but do not distinguish between stroke types or predict 6-month prognosis.
authors.affiliation: Biochemistry and Nutrition Research Center & Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Parizadeh
authors.forename: Mahmoud Reza
authors.initials: MR
authors.lastname: Azarpazhooh
authors.forename: Naser
authors.initials: N
authors.lastname: Mobarra
authors.forename: Mohsen
authors.initials: M
authors.lastname: Nematy
authors.forename: Dariush Hamidi
authors.initials: DH
authors.lastname: Alamdari
authors.forename: Shima
authors.initials: S
authors.lastname: Tavalaie
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.forename: Bahareh
authors.initials: B
authors.lastname: Hassankhani
authors.forename: Gordon
authors.initials: G
authors.lastname: Ferns
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
mesh_terms: D000975:Antioxidants / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000097:blood*; D020521:Stroke / Q000097:blood*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species