title: Early effects of oral administration of lafutidine with peppermint oil, compared with lafutidine alone, on intragastric pH values.
abstract: OBJECTIVE
  Ideally, medications for the treatment of acid-related diseases should have a rapid onset of action to promote hemostasis and the resolution of symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of lafutidine alone or combined with peppermint oil.
  
  
  METHODS
  Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 4 hours after a single oral administration of lafutidine (10 mg) or the administration of lafutidine (10 mg) with peppermint oil (0.64 mL). Each administration was separated by a 7-day washout period.
  
  
  RESULTS
  No significant difference in the average pH was observed during the 4-hour period after the combined administration of lafutidine and peppermint oil and after the administration of lafutidine alone (median gastric pH: 5.09 versus 5.29; p = 0.3122).
  
  
  CONCLUSIONS
  In H. pylori-negative healthy male subjects, an oral dose of lafutidine combined with peppermint oil did not increase the intragastric pH faster than lafutidine alone.
authors.affiliation: Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iida
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inamori
authors.forename: Tahashi
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Hiroki
authors.initials: H
authors.lastname: Endo
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Hosono
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Akiyama
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Koji
authors.initials: K
authors.lastname: Fujita
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Masato
authors.initials: M
authors.lastname: Yoneda
authors.forename: Tomoko
authors.initials: T
authors.lastname: Koide
authors.forename: Chikako
authors.initials: C
authors.lastname: Tokoro
authors.forename: Ayumu
authors.initials: A
authors.lastname: Goto
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Abe
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kirikoshi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kubota
authors.forename: Satoru
authors.initials: S
authors.lastname: Saito
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
mesh_terms: D000081:Acetamides / Q000008:administration & dosage*; D000284:Administration, Oral; D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D018592:Cross-Over Studies; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D036142:Mentha piperita; D010880:Piperidines / Q000008:administration & dosage*; D010938:Plant Oils / Q000008:administration & dosage*; D011725:Pyridines / Q000008:administration & dosage*; D018709:Statistics, Nonparametric
chemical_list: D000081:Acetamides; D000897:Anti-Ulcer Agents; D010880:Piperidines; D010938:Plant Oils; D011725:Pyridines; C076948:lafutidine; C015424:peppermint oil