title: pH- and Temperature-Responsive P(DMAEMA-GMA)-Alginate Semi-IPN Hydrogels Formed by Radical and Ring-Opening Polymerization for Aminophylline Release.
abstract: A novel poly((2-dimethylamino) ethyl methacrylate-glycidyl methacrylate)-alginate (P(DMAEMA-GMA)alginate) semi-IPN hydrogel was synthesized via radical polymerization of the double bonds and ring-opening of the epoxy groups without using catalyst and cross-linker. (1)H-NMR, FT-IR and DSC data were consistent with the expected structures for the hydrogels. The interior morphology of the hydrogels was also investigated by SEM. The swelling ratio and compressive strength of the hydrogels were measured. The semi-IPN hydrogel had pH and temperature sensitivity, and pH-sensitive points of all hydrogels were found to be at pH 5.0. The release behavior of the model drug, aminophylline, was found to be dependent on the hydrogel composition and environment pH, which manifests that these materials have potential applications as intelligent drug carriers.
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Gao
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
mesh_terms: D000327:Adsorption; D000464:Alginates / Q000737:chemistry*; D000628:Aminophylline / Q000737:chemistry*; D000818:Animals; D002417:Cattle; D004337:Drug Carriers / Q000737:chemistry; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D055595:Mechanical Phenomena; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D011489:Protein Denaturation; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013696:Temperature
chemical_list: D000464:Alginates; D004337:Drug Carriers; D006603:Hexuronic Acids; D020100:Hydrogels; D011108:Polymers; D011109:Polymethacrylic Acids; D012710:Serum Albumin, Bovine; D000628:Aminophylline; D020723:Glucuronic Acid