title: Oral complications of targeted cancer therapies: a narrative literature review.
abstract: The aim of the present study was to investigate the available literature regarding the oral side effects or adverse events associated with targeted cancer therapy. Common oral toxicities include the terms mucositis, stomatitis, dysphagia, xerostomia, pharyngitis, and taste alterations. Aims of treatment included molecules and pathways involved in carcinogenesis reported in the literature were EGFRI, VEGF, mTOR, mAbs, TKIs, and multi-kinase inhibitors. Common targeted therapies used in clinical practice or under-investigation included cetuximab, panitumumab, erlotinib, sorafenib, sunitinib malate, imatinib mesylate, bevacizumab, trastuzumab, lapatinib, and mTORs. One hundred and forty-three articles were considered relevant and included in this review. The majority of studies did not specifically address oral toxicities or include an oral clinical exam, which may lead to underreported and under-investigated oral toxicities. Further investigation is necessary to determine if the initial impression that targeted therapy produces milder oral toxicities than conventional cancer treatment is accurate.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Radiology and Medicine, New York University, College of Dentistry, New York, NY 10010, USA. alw4@nyu.edu
authors.forename: A L
authors.initials: AL
authors.lastname: Watters
authors.forename: J B
authors.initials: JB
authors.lastname: Epstein
authors.forename: M
authors.initials: M
authors.lastname: Agulnik
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D003680:Deglutition Disorders / Q000139:chemically induced* / Q000628:therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D052016:Mucositis / Q000139:chemically induced* / Q000628:therapy; D010612:Pharyngitis / Q000139:chemically induced* / Q000628:therapy; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D014987:Xerostomia / Q000139:chemically induced* / Q000628:therapy
chemical_list: D000911:Antibodies, Monoclonal; D047428:Protein Kinase Inhibitors