title: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging of bone marrow in healthy individuals.
abstract: BACKGROUND
  Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) displays microcirculation and permeability by application of contrast-media and diffusion-weighted imaging (DWI) is a tool for quantification of cellularity in the investigated area. Recently published examples cover breast cancer, CNS tumors, head and neck cancer, gastrointestinal cancer, prostate cancer as well as hematologic malignancies.
  
  
  OBJECTIVE
  To investigated the influence of age, sex, and localization of the investigated region on findings of DCE-MRI and DWI.
  
  
  METHODS
  DCE-MRI-parameters amplitude A and exchange rate constant kep as well as the DWI-parameter ADC of the bone marrow of the lumbar vertebral column of 30 healthy individuals covering the typical range of age of tumor patients were evaluated. ADC was calculated using b=0 and a maximal b value of either 400 or 750 s/mm(2).
  
  
  RESULTS
  Amplitude A of DCE-MRI decreased with age (P = 0.01) and amplitude A, exchange rate constant kep as well as ADC based on b = 400 s/mm(2) and b = 750 s/mm(2,) respectively, decreased significantly from the first to the fifth lumbar vertebra with P = 0.02, P = 0.05, P = 0.003, and P = 0.002, respectively.
  
  
  CONCLUSIONS
  Quantitative parameters of functional imaging techniques in bone marrow are influenced by the age of the examined individual and the anatomical location of the investigated region.
authors.affiliation: Department of Radiology, German Cancer Research Center, Heidelberg, Germany. j.hillengass@dkfz.de
authors.forename: Jens
authors.initials: J
authors.lastname: Hillengass
authors.forename: Bram
authors.initials: B
authors.lastname: Stieltjes
authors.forename: Tobias
authors.initials: T
authors.lastname: Bäuerle
authors.forename: Fabienne
authors.initials: F
authors.lastname: McClanahan
authors.forename: Christiane
authors.initials: C
authors.lastname: Heiss
authors.forename: Thomas
authors.initials: T
authors.lastname: Hielscher
authors.forename: Barbara
authors.initials: B
authors.lastname: Wagner-Gund
authors.forename: Verena
authors.initials: V
authors.lastname: Habetler
authors.forename: Hartmut
authors.initials: H
authors.lastname: Goldschmidt
authors.forename: Heinz-Peter
authors.initials: HP
authors.lastname: Schlemmer
authors.forename: Stefan
authors.initials: S
authors.lastname: Delorme
authors.forename: Christian M
authors.initials: CM
authors.lastname: Zechmann
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000033:anatomy & histology*; D003287:Contrast Media / Q000008:administration & dosage; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D008159:Lumbar Vertebrae / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA