title: Corpus callosum differences associated with persistent stuttering in adults.
abstract: Recent studies have implicated anatomical differences in speech-relevant brain regions of adults who stutter (AWS) compared to normally fluent adults (NFA). The present study focused on the region of the corpus callosum (CC) which is involved in interhemispheric processing between the left and right cerebral hemispheres. Two-dimensional segmentation of area and voxel-based morphometry were used to evaluate the corpus callosum. Results revealed that the rostrum and anterior midbody of the CC were larger in AWS than NFA. In addition, the overall callosa area was larger in AWS than NFA. The group comparison of white matter volume showed a cluster of increased white matter volume predominantly encompassing the rostrum across the midline portion in AWS. These results potentially reflect anatomical changes associated with differences in the hemispheric distribution of language processes that have been reported previously in AWS.
authors.affiliation: Department of Speech and Hearing Science, University of Illinois at Urbana-Champaign, 901 S. Sixth Street, Champaign, IL 61820, USA. choo1@illinois.edu
authors.forename: Ai Leen
authors.initials: AL
authors.lastname: Choo
authors.forename: Shelly Jo
authors.initials: SJ
authors.lastname: Kraft
authors.forename: William
authors.initials: W
authors.lastname: Olivero
authors.forename: Nicoline G
authors.initials: NG
authors.lastname: Ambrose
authors.forename: Harish
authors.initials: H
authors.lastname: Sharma
authors.forename: Soo-Eun
authors.initials: SE
authors.lastname: Chang
authors.forename: Torrey M
authors.initials: TM
authors.lastname: Loucks
mesh_terms: D000328:Adult; D003337:Corpus Callosum / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012720:Severity of Illness Index; D013342:Stuttering / Q000473:pathology*; D055815:Young Adult