title: Defining rare variants by their frequencies in controls may increase type I error.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lemire
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003198:Computer Simulation; D005787:Gene Frequency; D014644:Genetic Variation; D055106:Genome-Wide Association Study / Q000706:statistics & numerical data*; D006801:Humans; D015228:Hypertriglyceridemia / Q000235:genetics; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide