title: Genome-wide association scan of korean autism spectrum disorders with language delay: a preliminary study.
abstract: OBJECTIVE
  Communication problems are a prevalent symptom of autism spectrum disorders (ASDs), which have a genetic background. Although several genome-wide studies on ASD have suggested a number of candidate genes, few studies have reported the association or linkage of specific endophenotypes to ASDs.
  
  
  METHODS
  Forty-two Korean ASD patients who showed a language delay were enrolled in this study with their parents. We performed a genome-wide scan by using the Affymetrix SNP Array 5.0 platform to identify candidate genes responsible for language delay in ASDs.
  
  
  RESULTS
  We detected candidate single-nucleotide polymorphisms (SNPs) in chromosome 11, rs11212733 (p-value=9.76×10(-6)) and rs7125479 (p-value=1.48×10(-4)), as a marker of language delay in ASD using the transmission disequilibrium test and multifactor dimensionality reduction test.
  
  
  CONCLUSIONS
  Although our results suggest that several SNPs are associated with language delay in ASD, rs11212733 we were not able to observe any significant results after correction of multiple comparisons. This may imply that more samples may be required to identify genes associated with language delay in ASD.
authors.affiliation: Department of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Soo-Churl
authors.initials: SC
authors.lastname: Cho
authors.forename: Hee Jeong
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Mira
authors.initials: M
authors.lastname: Park
authors.forename: In Hee
authors.initials: IH
authors.lastname: Cho
authors.forename: Boong-Nyun
authors.initials: BN
authors.lastname: Kim
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Min-Sup
authors.initials: MS
authors.lastname: Shin
authors.forename: Tae-Won
authors.initials: TW
authors.lastname: Park
authors.forename: Jung-Woo
authors.initials: JW
authors.lastname: Son
authors.forename: Un-Sun
authors.initials: US
authors.lastname: Chung
authors.forename: Hyo-Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Young-Hui
authors.initials: YH
authors.lastname: Yang
authors.forename: Je-Ouk
authors.initials: JO
authors.lastname: Kang
authors.forename: So Young
authors.initials: SY
authors.lastname: Yang
authors.forename: Soon Ae
authors.initials: SA
authors.lastname: Kim