title: Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex.
abstract: Exposure to hypoxia and hyperoxia in a rodent model of perinatal ischemia results in delayed cell death and inflammation. Hyperoxia increases oxidative stress that can trigger inflammatory cascades, neutrophil activation, and brain microvascular injury. Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.
authors.affiliation: University of Texas Medical Branch, Galveston, TX 77555, USA. Regino.perez-polo@utmb.edu
authors.forename: J Regino
authors.initials: JR
authors.lastname: Perez-Polo
authors.forename: Conor B
authors.initials: CB
authors.lastname: Reilly
authors.forename: Harriet C
authors.initials: HC
authors.lastname: Rea
mesh_terms: D000818:Animals; D016923:Cell Death; D051546:Cyclooxygenase 2 / Q000378:metabolism; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D010100:Oxygen / Q000378:metabolism*; D011247:Pregnancy; D011453:Prostaglandins / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011453:Prostaglandins; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2; D010100:Oxygen