title: Titanium back plate for a PMMA keratoprosthesis: clinical outcomes.
abstract: OBJECTIVE
  To compare the rate of retroprosthetic membrane (RPM) formation in Boston Keratoprosthesis (BKPro) with polymethyl methacrylate (PMMA) versus titanium backplates.
  
  
  METHODS
  Retrospective comparative chart review.
  
  
  METHODS
  Multicenter study population: a total of 78 eyes with keratoprosthesis implants with either PMMA or titanium backplates were included in the study. To be included in the study, all subjects had to have completed a minimum of 6-month follow-up period. Incidence of RPM development at 6-month postoperative period was noted across the study population. PMMA and titanium backplates were then compared by their rate of association with subsequent RPM.
  
  
  RESULTS
  Twenty-three out of 55 eyes (41.8%) with PMMA backplates and three out of 23 eyes (13.0%) with titanium backplates had developed an RPM at 6 months after implantation. The titanium backplates were associated with significantly less RPM formation than PMMA backplates (p = 0.014, Chi-square test).
  
  
  CONCLUSIONS
  Titanium seems to be associated with less RPM formation than PMMA when used as a material for the BKPro back plate.
authors.affiliation: Cornea Service, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Todani
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Ciolino
authors.forename: Jared D
authors.initials: JD
authors.lastname: Ament
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Colby
authors.forename: Roberto
authors.initials: R
authors.lastname: Pineda
authors.forename: Michael W
authors.initials: MW
authors.lastname: Belin
authors.forename: James V
authors.initials: JV
authors.lastname: Aquavella
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
authors.forename: Claes H
authors.initials: CH
authors.lastname: Dohlman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003316:Corneal Diseases / Q000601:surgery*; D016039:Corneal Transplantation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D019904:Polymethyl Methacrylate; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012189:Retrospective Studies; D013997:Time Factors; D014025:Titanium; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019904:Polymethyl Methacrylate; D014025:Titanium