title: Primary graft dysfunction.
abstract: Primary graft dysfunction (PGD) is the most important cause of early morbidity and mortality following lung transplantation. PGD affects up to 25% of all lung transplant procedures and currently has no proven preventive therapy. Lung transplant recipients who recover from PGD may have impaired long-term function and an increased risk of bronchiolitis obliterans syndrome. This article aims to provide a state-of-the-art review of PGD epidemiology, outcomes, and risk factors, and to summarize current efforts at biomarker development and novel strategies for prevention and treatment.
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. james.lee@uphs.upenn.edu
authors.forename: James C
authors.initials: JC
authors.lastname: Lee
authors.forename: Jason D
authors.initials: JD
authors.lastname: Christie
mesh_terms: D015415:Biomarkers / Q000097:blood; D006801:Humans; D016040:Lung Transplantation; D055031:Primary Graft Dysfunction / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D012307:Risk Factors
chemical_list: D015415:Biomarkers