title: Painful legs and moving toes.
abstract: The syndrome of painful legs-moving toes (PLMT) is an adult-onset, rare disorder characterized by pain, typically of a neuropathic quality, in the feet or legs, associated with writhing movements of one or more toes. It is the pain which usually brings the patient to medical attention. The syndrome may be unilateral or bilateral. Identical toe movements may occur without pain, referred to as: "painless legs-moving toes," and a similar condition affects the upper limbs: "painful arms-moving fingers." The pathophysiology of PLMT and its variants is not known but most reports suggest an association with a peripheral lesion, usually at the level of the root or nerve, though in many cases no cause is found. It has been suggested that a peripheral lesion causes aberrant input leading to "central reorganization," probably at the level of the spinal cord, and that the latter is responsible for the pain and movement. Treatment is often unsatisfactory and many drugs commonly used for neuropathic pain have been reported anecdotally to help (e.g., gabapentin). Other anecdotal therapies include spinal blocks, spinal cord stimulation, and local injection of botulinum toxin.
authors.affiliation: Department of Neurology, Maryland Parkinson's Disease and Movement Disorders Center, University of Maryland School of Medicine, Baltimore 21201, USA. sreich@som.umaryland.edu
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Reich
mesh_terms: D064107:Aurora Kinase B; D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D006801:Humans; D007866:Leg / Q000503:physiopathology*; D009068:Movement / Q000502:physiology*; D010146:Pain / Q000175:diagnosis / Q000473:pathology*; D017346:Protein Serine-Threonine Kinases; D014034:Toes / Q000503:physiopathology*
chemical_list: D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; C576957:AurB protein, Drosophila; D064107:Aurora Kinase B; D017346:Protein Serine-Threonine Kinases