title: Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists.
abstract: We discovered novel peroxisome proliferator-activated receptor δ agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPARδ transactivation activity. Furthermore, it stimulated the differentiation of oligodendrocyte precursor cells in vitro. This indicates that this potential drug may be effective for the treatment of demyelinating disorders such as multiple sclerosis.
authors.affiliation: Discovery Research Laboratories, Nippon Chemiphar Co. Ltd, Hikokawado, Misato, Saitama, Japan. sakuma@os.rim.or.jp
authors.forename: Shogo
authors.initials: S
authors.lastname: Sakuma
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Endo
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanda
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Satomi
authors.initials: S
authors.lastname: Yamasaki
authors.forename: Tomio
authors.initials: T
authors.lastname: Yamakawa
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D006801:Humans; D007555:Isoxazoles / Q000737:chemistry* / Q000494:pharmacology*; D009836:Oligodendroglia / Q000166:cytology / Q000187:drug effects; D047494:PPAR delta / Q000819:agonists* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: C441200:1,2-benzisoxazole; D007555:Isoxazoles; D047494:PPAR delta