title: Uptake of biomedical interventions for prevention of sexually transmitted HIV.
abstract: OBJECTIVE
  To examine the population-level effects of introducing and/or expanding biomedical interventions for prevention of human immunodeficiency virus (HIV) sexually transmitted infections through mathematical modeling.
  
  
  RESULTS
  Successes of several ground-breaking clinical trials have invigorated the field of HIV prevention with new enthusiasm and opportunities for research into and application of biomedical HIV prevention. Mathematical modeling has advanced in tandem with valuable contributions to both investigative science and public health. New models provide qualitative and quantitative insights regarding the epidemiological impact of the uptake of biomedical interventions, singly and/or in combination including treatment of sexually transmitted infections, condom use, male circumcision, antiretroviral treatment and pre-exposure prophylaxis and vaccine for HIV prevention.
  
  
  CONCLUSIONS
  Biomedical interventions are critical for reversing the HIV pandemic. Mathematical modeling is invaluable for informed biomedical HIV prevention research, policy and practice.
authors.affiliation: Department of Infectious Diseases, Cleveland Clinic Foundation, Cleveland, Ohio, USA. abbasu@ccf.org
authors.forename: Ume L
authors.initials: UL
authors.lastname: Abbas
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018890:Chemoprevention / Q000379:methods; D002944:Circumcision, Male; D002986:Clinical Trials as Topic; D017280:Condoms / Q000706:statistics & numerical data; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005260:Female; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D008297:Male; D015233:Models, Statistical; D015229:Sexually Transmitted Diseases, Viral / Q000517:prevention & control* / Q000635:transmission
chemical_list: D016915:AIDS Vaccines; D019380:Anti-HIV Agents