title: Role of the XRCC5/XRCC6 dimer in carcinogenesis and pharmacogenomics.
abstract: Over the past few decades, the incidence of cancer has rapidly increased all over the world and cancer remains a major threat to public health. It is believed that cancer results from a series of genetic alterations that lead to the progressive disorder of the normal mechanisms controlling cell proliferation, differentiation, death and/or genomic stability. The response of the cell to genetic injury and its ability to maintain genomic stability by means of a variety of DNA repair mechanisms are therefore essential in preventing tumor initiation and progression. From the same viewpoint, the relative role of DNA repair as a biomarker for prognosis, predictor of drug and therapy responses or indeed as a target for novel gene therapy, is very promising. In this article, we have summarized the studies investigating the association between the XRCC5/XRCC6 dimer and the susceptibility to multiple cancers and discuss its role in carcinogenesis and its potential application to anticancer drug discovery.
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan, Republic of China. datian@mail.cmuh.org.tw
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.forename: Cheng-Nan
authors.initials: CN
authors.lastname: Wu
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D034961:Antigens, Nuclear / Q000235:genetics / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D053903:DNA Breaks, Double-Stranded; D004265:DNA Helicases / Q000235:genetics* / Q000502:physiology*; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D042822:Genomic Instability; D006801:Humans; D000072200:Ku Autoantigen; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D055503:Protein Multimerization
chemical_list: D016588:Anticarcinogenic Agents; D034961:Antigens, Nuclear; D004268:DNA-Binding Proteins; D004265:DNA Helicases; C106893:XRCC5 protein, human; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen