title: Synergistic inhibition of R5 HIV-1 by maraviroc and CCR5 antibody HGS004 in primary cells: implications for treatment and prevention.
abstract: CCR5 blockers inhibit CCR5-tropic (R5) HIV-1, including strains resistant to other antiretrovirals. We demonstrate that the CCR5 antibody HGS004 and the CCR5 antagonist maraviroc have potent antiviral synergy against R5 HIV-1, translating into dose reductions of more than 10-fold for maraviroc and more than 150-fold for HGS004. These data, together with the high barrier of resistance to HGS004, suggest that combinations of maraviroc and HGS004 could provide effective preventive and therapeutic strategies against R5 HIV-1.
authors.affiliation: Institute of Human Virology, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Latinovic
authors.forename: Nhut
authors.initials: N
authors.lastname: Le
authors.forename: Marvin
authors.initials: M
authors.lastname: Reitz
authors.forename: Ranajit
authors.initials: R
authors.lastname: Pal
authors.forename: Anthony
authors.initials: A
authors.lastname: DeVico
authors.forename: James S
authors.initials: JS
authors.lastname: Foulke
authors.forename: Robert R
authors.initials: RR
authors.lastname: Redfield
authors.forename: Alonso
authors.initials: A
authors.lastname: Heredia
mesh_terms: D065100:CCR5 Receptor Antagonists; D003510:Cyclohexanes / Q000037:antagonists & inhibitors / Q000276:immunology*; D024882:Drug Resistance, Viral / Q000187:drug effects* / Q000276:immunology; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D015497:HIV-1 / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D000077592:Maraviroc; D019713:Receptors, CCR5 / Q000276:immunology*; D014230:Triazoles / Q000037:antagonists & inhibitors / Q000276:immunology*
chemical_list: D065100:CCR5 Receptor Antagonists; D003510:Cyclohexanes; D019713:Receptors, CCR5; D014230:Triazoles; D000077592:Maraviroc