title: Antitussive effect of bakumondoto a fixed kampo medicine (six herbal components) for treatment of post-infectious prolonged cough: controlled clinical pilot study with 19 patients.
abstract: Bakumondoto (TJ-29) is a traditional herbal medicine that has been used in Japan for the treatment of bronchitis, bronchial asthma, and cough. This study investigated the effect of TJ-29 for the treatment of post-infectious prolonged cough. We performed a multicenter randomized controlled trial treating patients without (group A, n=11) or with TJ-29 (group B, n=8) for a total of 2 weeks using a beta 2 stimulant as the basal agent. Efficacy and safety were compared by a cough diary, VAS and sleeping questionnaire. At 4 and 5 days after treatment, the cough score of group B showed significant improvement compared with group A, demonstrating an early antitussive effect. At the assessment 2 weeks after treatment start, both groups showed similar levels of improvement in the cough score. No significant difference was observed in the VAS and the sleeping questionnaire items. In conclusion, oral TJ-29 administration could be useful and safe for the treatment of post-infectious prolonged cough.
authors.affiliation: Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan. kirifune@m.ehime-u.ac.jp
authors.forename: Kazunori
authors.initials: K
authors.lastname: Irifune
authors.forename: Hironobu
authors.initials: H
authors.lastname: Hamada
authors.forename: Ryoji
authors.initials: R
authors.lastname: Ito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Katayama
authors.forename: Akira
authors.initials: A
authors.lastname: Watanabe
authors.forename: Aki
authors.initials: A
authors.lastname: Kato
authors.forename: Seigo
authors.initials: S
authors.lastname: Miyoshi
authors.forename: Naohiko
authors.initials: N
authors.lastname: Hamaguchi
authors.forename: Ryo
authors.initials: R
authors.lastname: Toyozawa
authors.forename: Sachiko
authors.initials: S
authors.lastname: Hamaguchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abe
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Nishimura
authors.forename: Jitsuo
authors.initials: J
authors.lastname: Higaki
mesh_terms: D000328:Adult; D000368:Aged; D000996:Antitussive Agents / Q000627:therapeutic use*; D003371:Cough / Q000188:drug therapy* / Q000209:etiology; D018592:Cross-Over Studies; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D020835:Medicine, Kampo; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods*; D010865:Pilot Projects; D012141:Respiratory Tract Infections / Q000150:complications
chemical_list: D000996:Antitussive Agents; D004365:Drugs, Chinese Herbal; C083181:bakumondo-to