title: Endovenous laser ablation: the role of intraluminal blood.
abstract: OBJECTIVE
  In this histological study, the role of the intraluminal blood during endovenous laser ablation was assessed.
  
  
  METHODS
  In 12 goats, 24 lateral saphenous veins were treated with a 1500-nm diode laser. Four goats were treated in an anti-Trendelenburg position (group 1). The next four goats were treated in a Trendelenburg position (group 2) and the remaining four goats in the Trendelenburg position with additional injection of tumescent liquid (group 3). Postoperatively, the veins were removed after 1 week and sent for histological examination. We measured the number of perforations. Vein wall necrosis and the perivenous tissue destruction were quantified using a graded scale.
  
  
  RESULTS
  The 'calculated total vein wall destruction' was significantly higher in the third group (81.83%), as compared with groups one (61.25%) (p < 0.001) and two (65.92%) (p < 0.001). All three groups showed a significant difference in the perivenous tissue destruction scale (p < 0.001) with the lowest score occurring in the third group. Vein wall perforations were significantly more frequent in groups one and two as compared with the third group (T-test respectively p < 0.001, p = 0.02).
  
  
  CONCLUSIONS
  A higher intraluminal blood volume results in reduced total vein wall destruction. Injection of tumescent liquid prevents the perivenous tissue destruction and minimises the number of perforations.
authors.affiliation: Department of Vascular Surgery Sint-Andriesziekenhuis, Tielt, Belgium. marc.vuylsteke@me.com
authors.forename: M E
authors.initials: ME
authors.lastname: Vuylsteke
authors.forename: Th
authors.initials: T
authors.lastname: Martinelli
authors.forename: J
authors.initials: J
authors.lastname: Van Dorpe
authors.forename: J
authors.initials: J
authors.lastname: Roelens
authors.forename: S
authors.initials: S
authors.lastname: Mordon
authors.forename: I
authors.initials: I
authors.lastname: Fourneau
mesh_terms: D000818:Animals; D001810:Blood Volume; D006041:Goats; D018475:Head-Down Tilt; D007275:Injections, Intravenous; D053685:Laser Therapy / Q000009:adverse effects / Q000295:instrumentation; D054023:Lasers, Semiconductor; D009336:Necrosis; D012501:Saphenous Vein / Q000473:pathology / Q000601:surgery*; D012965:Sodium Chloride / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D012965:Sodium Chloride