title: [Significance of Nogo-A expression of atrophic muscle fibers in diagnosis of amyotrophic lateral sclerosis].
abstract: OBJECTIVE
  To investigate significance of Nogo-A in atrophic muscle fibers in diagnosis of amyotrophic lateral sclerosis (ALS).
  
  
  METHODS
  Forty cases which were diagnosed definitely by clinical, pathological or DNA analysis were included. All of the cases underwent muscle biopsies in order to carry out Nogo-A immunostaining.
  
  
  RESULTS
  Nogo-A expression was detected in the atrophic muscle fibers but in either neurogenic disease or myogenic disease, the atrophic muscle fibers demonstrated expression of Nogo-A. As compared with the stainings of NADH-TR and ATPase, it was showed that Nogo-A positive fibers were mainly type I fibers.
  
  
  CONCLUSIONS
  Our results show that the presence of Nogo-A in diseased human muscle biopsies is not limited to ALS, therefore it cannot be the standard for ALS diagnosis.
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: A-ping
authors.initials: AP
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Qin
authors.initials: Q
authors.lastname: Liao
authors.forename: Lu
authors.initials: L
authors.lastname: Tang
authors.forename: Dong-shen
authors.initials: DS
authors.lastname: Fan
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000378:metabolism*; D001284:Atrophy; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology; D009185:Myelin Proteins / Q000096:biosynthesis*; D000070798:Nogo Proteins
chemical_list: D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human