title: Stability of vitamin B complex in multivitamin and multimineral supplement tablets after space flight.
abstract: The effect of storage in space on the stability of vitamin B complex in two commercial vitamin tablets was examined. Multiple vitamin samples returned after storage on the space shuttle and International Space Station (ISS) along with two ground control and three positive control groups were included in the study. Content of vitamin B(3) in the tablets and in vitro dissolution rate were determined using a modified high performance liquid chromatographic assay from USP/NF 2010. Results indicate that vitamin B(3) in one of the brands tested (#2) may be subject to marginal degradation after storage on ISS for 4 months as indicated by the chromatograms for all six tablets showing a split peak appearing as a notch at the peak tip. Chromatograms were not different for ground and flight samples for Brand #1 suggesting that this may be more suitable for use in space.
authors.affiliation: Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Ave, Boston, MA 02115, USA. monica.chuong@mcphs.edu
authors.forename: Monica C
authors.initials: MC
authors.lastname: Chuong
authors.forename: Dev
authors.initials: D
authors.lastname: Prasad
authors.forename: Barbara
authors.initials: B
authors.lastname: Leduc
authors.forename: Brian
authors.initials: B
authors.lastname: Du
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Putcha
mesh_terms: D001682:Biological Availability; D002845:Chromatography / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D019587:Dietary Supplements; D004355:Drug Stability; D004356:Drug Storage; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000528:radiation effects; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D012995:Solubility; D013026:Space Flight; D018531:Spacecraft; D013696:Temperature; D013997:Time Factors; D014803:Vitamin B Complex / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations; D014803:Vitamin B Complex