title: [Meta-analysis on the incidence and risk factors of herpes simplex virus type 2 infection].
abstract: OBJECTIVE
  To determine the global incidence and risk factors of herpes simplex virus type 2 (HSV-2).
  
  
  METHODS
  Meta-analysis was performed to systematically and quantitatively review all the original research papers and reports that were published in 1990 - 2010 on the global incidence of HSV-2. Pooled incidence, pooled hazard ratios, publication bias, heterogeneity and sensitivity analysis for those studies were calculated or conducted using Stata 10.0.
  
  
  RESULTS
  HSV-2 incidence varied considerably across different countries, regions and/or populations, with a range from 1.0 to 23.1/100 person-years (PYs). Africa and United States were highly epidemic with HSV-2 while females and HIV-infected people were at higher risk of HSV-2 infection, whereas HSV-1 infection status was not significantly associated with acquisition of HSV-2 infection.
  
  
  CONCLUSIONS
  HSV-2 incidence varied considerably among countries, regions and populations, which called for different and tailored control strategies. More research was also needed in China to examine the HSV-2 incidence and risk factors in different regions and populations.
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, the Key Laboratory of Public Health Safety of Ministry of Education, Shanghai, China.
authors.forename: Xiao-dan
authors.initials: XD
authors.lastname: Shao
authors.forename: Tie-jun
authors.initials: TJ
authors.lastname: Zhang
authors.forename: Na
authors.initials: N
authors.lastname: He
mesh_terms: D006561:Herpes Simplex / Q000453:epidemiology*; D018258:Herpesvirus 2, Human; D006801:Humans; D015994:Incidence; D012307:Risk Factors