title: [Mechanisms of contractile action of acetylcholine on hepatic veins].
abstract: In acute experiments on anesthetized rats, acetylcholine (Ach) constricts hepatic venous vessels, causing blood mobilization from the liver, and dilates the sphincters of hepatic veins at the exit from this organ, contributing to the intensification of the outflow of blood deposited in the liver. Vasoconstrictor reactions of capacitive vessels of the liver to Ach are realized through M-cholinoreceptors on endotheliocytes with further involvement of messenger, possibly noradrenaline, which activates alpha-adrenoreceptors on smooth muscle cells (SMC) of capasitive vessels. Dilation of Hv sphincters is carried out due to Ach-induced release of messenger in the vessel wall, probably adrenaline, which in turn activates beta-adrenoreceptors on SMC of the Hv. It is possible, that in such reaction partially involved NO.
authors.forename: P I
authors.initials: PI
authors.lastname: Ianchuk
authors.forename: T P
authors.initials: TP
authors.lastname: Prykhod'ko
authors.forename: O M
authors.initials: OM
authors.lastname: Pasichnichenko
authors.forename: A A
authors.initials: AA
authors.lastname: Tieriekhov
authors.forename: V O
authors.initials: VO
authors.lastname: Tsybenko
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D018674:Adrenergic Antagonists / Q000494:pharmacology; D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004146:Dioxanes / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D006503:Hepatic Veins / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000098:blood supply / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism; D013152:Splanchnic Circulation / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D018674:Adrenergic Antagonists; D004146:Dioxanes; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D001262:Atenolol; D000109:Acetylcholine; C009143:proroxan; D010646:Phentolamine