title: Clinical correlates of quality of life in Tourette syndrome.
abstract: Tourette syndrome (TS) is a neurodevelopmental disorder involving tics, which is frequently accompanied by comorbid obsessive compulsive (OCD) or attention deficit hyperactivity disorder (ADHD). Individuals with TS often report poor quality of life (QoL) in comparison with the general population. This study investigated the clinical correlates of QoL in young people with TS using a self-report multidimensional QoL measure, and a range of clinical scales used to assess tic severity and the symptoms of anxiety, depression, OCD, ADHD and other emotional and behavioral symptoms. Symptoms of depression, OCD, and ADHD appeared to have a widespread negative impact on QoL, but poorer QoL was not associated with increased tic severity. Greater emotional and behavioral difficulties, including symptoms of OCD, were among the best predictors of poor QoL in young people with TS.
authors.affiliation: Department of Neuropsychiatry, The Barberry National Centre for Mental Health, Birmingham, United Kingdom. clare.eddy@bsmhft.nhs.uk
authors.forename: Clare M
authors.initials: CM
authors.lastname: Eddy
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Cavanna
authors.forename: Mariangela
authors.initials: M
authors.lastname: Gulisano
authors.forename: Antonella
authors.initials: A
authors.lastname: Agodi
authors.forename: Martina
authors.initials: M
authors.lastname: Barchitta
authors.forename: Paola
authors.initials: P
authors.lastname: Calì
authors.forename: Mary M
authors.initials: MM
authors.lastname: Robertson
authors.forename: Renata
authors.initials: R
authors.lastname: Rizzo
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012044:Regression Analysis; D012720:Severity of Illness Index; D013223:Statistics as Topic; D005879:Tourette Syndrome / Q000503:physiopathology* / Q000523:psychology*