title: Radial die-wall pressure as a reliable tool for studying the effect of powder water activity on high speed tableting.
abstract: The effect of moisture as a function of water activity (Aw) on the compaction process is important to understand particle/water interaction and deformation. Studying powder/moisture interaction under pressure with radial die-wall pressure (RDWP) tool was never done. The aim of our study was to use this tool to study this interaction at high compression pressure and speed. Moreover, the effect of changing ejection cam angle (EA) of the machine on ejection force (EF) was investigated. Also, a new tool for prediction of tablet sticking was proposed. Materials with different deformation behaviors stored at low and high moisture conditions were used. Compaction simulation guided by modeling was applied. High Aw resulted in a low residual die-wall pressure (RDP) for all materials, and a high maximum die-wall pressure (MDP) for plastic materials, p < 0.05. This was due to the lubricating and plasticizing effects of water, respectively. However, microcrystalline cellulose showed capping at high Aw and compaction pressure. By increasing compression pressure at high Aw for all materials, effective fall time (EFT) was increased, p < 0.05, showing tendency for sticking. Increasing EA caused an increase of friction and EF for powders, p < 0.05. RDWP was a useful tool to understand particle/moisture interaction under pressure.
authors.affiliation: Industrial Pharmacy Research Group, Department of Pharmaceutical Sciences, University of Basel, Mülhauserstr 51, CH-4056 Basel, Switzerland.
authors.forename: Sameh
authors.initials: S
authors.lastname: Abdel-Hamid
authors.forename: Gabriele
authors.initials: G
authors.lastname: Betz
mesh_terms: D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000737:chemistry; D019245:Compressive Strength; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D004864:Equipment and Supplies; D005079:Excipients / Q000737:chemistry; D006813:Humidity; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D016062:Porosity; D011208:Powders / Q000737:chemistry*; D011312:Pressure; D013607:Tablets / Q000737:chemistry*; D013718:Tensile Strength; D014867:Water / Q000737:chemistry*
chemical_list: D005079:Excipients; D004364:Pharmaceutical Preparations; D011208:Powders; D013607:Tablets; D014867:Water; D002482:Cellulose; C109691:microcrystalline cellulose