title: [Preparation and in vitro release characteristics of curcumin in nanosuspensions].
abstract: OBJECTIVE
  To prepare curcumin albumin nanosuspensions and study its release characteristics in vitro.
  
  
  METHODS
  Curcumin albumin nanosuspensions were prepared by solvent evaporation method. The nanosuspensions were characterized in terms of morphology, size, encapsulation efficiency and in vitro drug release.
  
  
  RESULTS
  The mean size of albumin nanosuspensions before lyophilization was 245.2 nm and 240.3 nm after reconstitution. The distribution of particle size was uniform. The encapsulation efficiency was (42.39 +/- 0.91)%. In vitro release study revealed that the 72 h accumulative release percentage reached 96%.
  
  
  CONCLUSIONS
  The method described to prepare curcumin albumin nanosuspensions is simple. It might be a novel vehicle potentially for nanoparticle drug delivery system of curcumin.
authors.affiliation: Chongqing Key Laboratory of Biochemistry & Molecular Pharmnacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Liangke
authors.initials: L
authors.lastname: Zhang
authors.forename: Pei
authors.initials: P
authors.lastname: Yuan
authors.forename: Chengyuan
authors.initials: C
authors.lastname: Wang
mesh_terms: D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007700:Kinetics; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size
chemical_list: D004365:Drugs, Chinese Herbal; D003474:Curcumin