title: Refractory schizophrenia, clozapine and epilepsy : management strategies.
abstract: This case of refractory schizophrenia in a 28 year old male showed significant improvement with clozapine. But therapeutic doses of clozapine were associated with generalised tonic clonic seizures (GTCS). Addition of sodium valproate allowed adequate control of schizophrenic symptoms as well as seizures. EEG abnormality correlated surprisingly well with development of GTCS and subsequent improvement with anticonvulsant. Factors that lead to seizure-vulnerability in clozapine treated patients are discussed.
authors.affiliation: PRATHAMA GUHA, M.D., Resident, Central Institute of Psychiatry, Ranchi - 834006.
authors.forename: P
authors.initials: P
authors.lastname: Guha
authors.forename: H S
authors.initials: HS
authors.lastname: Nizamie