title: The role of brachytherapy in the definitive management of prostate cancer.
abstract: Over the past two decades, brachytherapy has played an ever expanding role in the definitive radiotherapy of prostate cancer. Brachytherapy surpasses external beam radiotherapy in its ability to deliver intense intraprostatic dose escalation. Although initially low dose rate permanent seed brachytherapy was favored for favorable risk prostate cancers, and high dose rate temporary brachytherapy for intermediate and advanced disease, both types of brachytherapy now have a place across all the risk groups of localized prostate cancer. This article will review indications and patient selection, planning and technical aspects, toxicity and efficacy for both low and high dose rate prostate brachytherapy.
authors.affiliation: British Columbia Cancer Agency, Center for the Southern Interior, Kelowna, British Columbia, Canada. jcrook@bccancer.bc.ca
authors.forename: J
authors.initials: J
authors.lastname: Crook
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D001706:Biopsy; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D058958:Organs at Risk; D010165:Palladium / Q000008:administration & dosage / Q000627:therapeutic use; D018579:Patient Selection; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D011785:Quality Assurance, Health Care; D011868:Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D016032:Randomized Controlled Trials as Topic; D014057:Tomography, X-Ray Computed; D014555:Urination Disorders / Q000209:etiology
chemical_list: D007457:Iodine Radioisotopes; D011868:Radioisotopes; D010165:Palladium