title: Experimental pharmacodynamics and analgesic efficacy of liposome-encapsulated hydromorphone in dogs.
abstract: The purpose of this study was to determine the experimental side effects of liposome-encapsulated hydromorphone (LE-Hydro) in beagles and to evaluate LE-Hydro analgesia in dogs undergoing ovariohysterectomies (OVH). Beagles were injected subcutaneously with 1-3 mg/kg LE-Hydro or 0.1 mg/kg hydromorphone. Dogs were evaluated for sedation, temperature, respiratory rate, and heart rate. OVH dogs were injected with 2 mg/kg LE-Hydro subcutaneously or 0.2 mg/kg morphine and 0.05 mg/kg acepromazine intramuscularly. Side effects of LE-Hydro were within clinically acceptable limits. The analgesic efficacy was superior in dogs administered LE-Hydro at 12 hr postsurgically. LE-Hydro provided adequate, durable analgesia in dogs undergoing OVH.
authors.affiliation: Research Animal Resources Center, University of Wisconsin-Madison, Madison, WI, USA. lisakh@rarc.wisc.edu
authors.forename: Lisa
authors.initials: L
authors.lastname: Krugner-Higby
authors.forename: Lesley
authors.initials: L
authors.lastname: Smith
authors.forename: Brynn
authors.initials: B
authors.lastname: Schmidt
authors.forename: Laura
authors.initials: L
authors.lastname: Wunsch
authors.forename: Andrea
authors.initials: A
authors.lastname: Smetana
authors.forename: Carolyn
authors.initials: C
authors.lastname: Brown
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Heath
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D019540:Area Under Curve; D002626:Chemistry, Pharmaceutical; D004285:Dogs / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D004091:Hydromorphone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D007044:Hysterectomy / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D008657:Metabolic Clearance Rate; D010052:Ovariectomy / Q000662:veterinary; D010147:Pain Measurement / Q000662:veterinary; D011182:Postoperative Care / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D004091:Hydromorphone