title: Genetics of atopic dermatitis.
abstract: Atopic dermatitis (AD) is a multifactorial disease, with a strong genetic predisposition. Genome-wide studies as well as candidate gene studies revealed several susceptibility loci. Since the observation of a strong association of "loss of function" mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease.
authors.affiliation: Department of Dermatology and Allergy, University of Bonn, Germany.
authors.forename: Caroline
authors.initials: C
authors.lastname: Bussmann
authors.forename: Stephan
authors.initials: S
authors.lastname: Weidinger
authors.forename: Natalija
authors.initials: N
authors.lastname: Novak
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics; D000483:Alleles; D004252:DNA Mutational Analysis; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000235:genetics*; D004200:Diseases in Twins / Q000235:genetics; D000091344:Filaggrin Proteins; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007073:Immunoglobulin E / Q000097:blood; D007381:Intermediate Filament Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D012867:Skin / Q000276:immunology
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D007073:Immunoglobulin E