title: [Association between high sensitivity C-reactive protein levels in serum and the 5-year-accumulative-risk of diabetes].
abstract: OBJECTIVE
  To analyze the association between hs-CRP (high-sensitivity C-reactive protein) levels in serum and the 5-year-accumulative-risk of diabetes in a general population.
  
  
  METHODS
  Participants were from the cohort of Peking University residential community in the Chinese Multi-provincial Cohort Study (CMCS). Two surveys on cardiovascular risk factors and the measurements of serum hs-CRP levels were conducted in 2002 and 2007, respectively. Individuals with incomplete information and those having infectious diseases at baseline were excluded. A total of 1045 participants aged 45 to 74 years and free of diabetes at baseline were included in this analysis.
  
  
  RESULTS
  The age-standardized 5-year accumulative incidence rate of diabetes was 8.8% (male: 9.8%, female: 8.2%) and increased significantly with the level of hs-CRP in both women and men (P<0.01). After adjustment for age, hypertension, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, triglycerides, fasting glucose, smoking status and central obesity, people with hs-CRP≥3 mg/L had a 3.30 times higher risk of developing diabetes in men and 2.58 times for women when compared to those with hs-CRP<1 mg/L. The areas under the receiver operating characteristic curves of baseline hs-CRP level in predicting the incidence of diabetes were 0.619 (95%CI: 0.536-0.701) in men and 0.667 (95%CI: 0.585-0.749) in women.
  
  
  CONCLUSIONS
  Serum hs-CRP levels could predict the incidence of diabetes, indicating that inflammation might have great importance in the onset of diabetes.
authors.affiliation: Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.
authors.forename: Hai-hang
authors.initials: HH
authors.lastname: Liu
authors.forename: Dong
authors.initials: D
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Lan-ping
authors.initials: LP
authors.lastname: Qin
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Jia-yi
authors.initials: JY
authors.lastname: Sun
authors.forename: Miao
authors.initials: M
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Yue
authors.initials: Y
authors.lastname: Qi
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein