title: Clinical and molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli causing bacteremia in the Rotterdam Area, Netherlands.
abstract: We investigated the clinical and molecular characteristics of bacteremia caused by extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli over a 2-year period (2008 to 2009) in the Rotterdam region (including 1 teaching hospital and 2 community hospitals) of Netherlands. The majority of patients presented with community onset urinary and intra-abdominal infections, with an increase in prevalence during 2009. The majority of E. coli isolates produced CTX-M-15, and 4 sequence types (ST38, ST131, ST405, and ST648) predominated. There were significant differences in clinical and molecular characteristics between the 2 community hospitals.
authors.affiliation: 1Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, Netherlands.
authors.forename: Akke K
authors.initials: AK
authors.lastname: van der Bij
authors.forename: Gisele
authors.initials: G
authors.lastname: Peirano
authors.forename: Wil H F
authors.initials: WH
authors.lastname: Goessens
authors.forename: Eric R
authors.initials: ER
authors.lastname: van der Vorm
authors.forename: M
authors.initials: M
authors.lastname: van Westreenen
authors.forename: Johann D D
authors.initials: JD
authors.lastname: Pitout
mesh_terms: D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology*; D004926:Escherichia coli / Q000201:enzymology* / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases