title: Interferon successfully inhibited refractory cytomegalovirus infection and resulted in CD4+ T-cells increase in a patient with AIDS.
abstract: We report on a young male HIV-positive patient with cytomegalovirus (CMV) retinitis who received HAART and ganciclovir but could not gain immune restoration. One and a half years later, his CMV reoccurred. He was treated again with ganciclovir treatment combined with foscarnet treatment but failed. Finally, he was treated with recombinant human interferon alpha-2b (IFN-α2b) alone and acquired sustained inhibition to CMV. His CD4+ T-cell count increased to 186 cell/mm3 and gained partial immune restoration. Retinitis progression has stopped.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wen
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000276:immunology; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D003586:Cytomegalovirus Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins