title: Sporadic dementia of Alzheimer's type induced by streptozotocin promotes anxiogenic behavior in mice.
abstract: Alzheimer disease, a form of dementia in which loss of memory is the first and the most characteristic symptom, is frequently accompanied by affective symptoms. Intracerebroventricular (i.c.v.) injection of streptozotocin (STZ) to rodents has been reported as an appropriate model for sporadic dementia of Alzheimer's type (SDAT), characterized by a progressive impairment of memory. However, very little or nothing is known about non-cognitive behavioral effects (e.g. anxiety-like behavior) in the STZ model. In this context, the hypothesis to be tested in this study is if i.c.v. injection of STZ (0.1mg/site, 4 μl) induces anxiety-like behavior in mice. The findings of the present study indicate that i.c.v. injection of STZ in mice resulted in an anxiogenic behavior. Mice spent less time and decreased the number of entries in the open arms in the elevated plus-maze task. The latency to the first entry in the dark side in the light-dark box task was reduced by STZ. No difference was found in anxiety-like behavior between early and late time (i.e., at 7 and 21 days after infusion, respectively). These results indicate that i.c.v. STZ injection caused an anxiogenic behavior in mice.
authors.affiliation: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios. Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
authors.forename: Simone
authors.initials: S
authors.lastname: Pinton
authors.forename: Juliana Trevisan
authors.initials: JT
authors.lastname: da Rocha
authors.forename: Bibiana Mozzaquatro
authors.initials: BM
authors.lastname: Gai
authors.forename: Cristina Wayne
authors.initials: CW
authors.lastname: Nogueira
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000139:chemically induced / Q000523:psychology*; D000818:Animals; D001007:Anxiety / Q000097:blood / Q000139:chemically induced / Q000523:psychology*; D001362:Avoidance Learning / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D002755:Choice Behavior / Q000187:drug effects; D004195:Disease Models, Animal; D007276:Injections, Intraventricular; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013311:Streptozocin; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D013311:Streptozocin