title: Molecular characterization of an early invasive Staphylococcus epidermidis prosthetic joint infection.
abstract: Historically regarded as a skin commensal, Staphylococcus epidermidis has been increasingly implicated in invasive foreign body infections such as catheter-related bloodstream infections, indwelling device infections, and prosthetic joint infections. We report a case of an aggressive, difficult-to-eradicate, invasive prosthetic hip infection occurring early after hardware implant and associated with a high-grade bacteremia and assess its salient molecular characteristics. The clinical and molecular characteristics of this isolate mirror the pathogenesis and persistence commonly seen with invasive methicillin-resistant S. aureus and may be attributed to the combination of resistance genes (SCCmec type IV), putative virulence factors (arcA and opp3a), cytolytic peptide production (α-type phenol-soluble modulins), and biofilm adhesion, interaction, and maturation (bhp, aap, and β-type phenol-soluble modulins).
authors.affiliation: Section of Infectious Diseases, Department of Internal Medicine, Jersey Shore University Medical Center, Neptune, New Jersey, USA.
authors.forename: Marnie E
authors.initials: ME
authors.lastname: Rosenthal
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Dever
authors.forename: Calin S
authors.initials: CS
authors.lastname: Moucha
authors.forename: Kalyan D
authors.initials: KD
authors.lastname: Chavda
authors.forename: Michael
authors.initials: M
authors.lastname: Otto
authors.forename: Barry N
authors.initials: BN
authors.lastname: Kreiswirth
mesh_terms: D016470:Bacteremia / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics; D018441:Biofilms; D005260:Female; D006621:Hip Joint / Q000382:microbiology*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics*; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D037521:Virulence Factors / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors