title: [Delayed medical consequences of the Chernobyl accident in Armenia. Assessment of life quality and accelerated biological aging of accident liquidators].
abstract: In this paper, some final results of 25-year investigations carried out in Scientific Centre for Radiation Medicine and Burns MH RA (SCRMB) on the Armenian cohort of the Chernobyl accident consequences liquidators are shown. These results show that health conditions of the liquidators became worse during the whole observation period. A considerable development of both pathological states atypical of radiation damages and diseases, which may be considered as radiation-induced ones, was determined. Rise of the sickness rate of almost all organism systems, first of all, nervous, cardiovascular, respiratory and digestive ones, was observed. In 70% of liquidators the main disease was primarily detected after working on CNPP. In the intervening years, the average number of diagnoses per 1 liquidator increased from 1.5 in 1987 to 7-8 in the recent time. In addition to the detected diseases, particular functional shifts in neuropsychological and vegetative status of the liquidators were observed. The overwhelming majority of them have increased tonicity of the sympathetic vegetative nervous system, asthenic and depressive syndromes occurring in the form of weakness, somnolence, mood instability, mental capacity decrease, and memory defects. In the paper, the results of investigations aimed at clarification of changes in biological aging processes of the liquidators and assessment of their "life quality" features in terms of physical, psychical and social welfare are considered. Biological aged-related passportization in a definite part of liquidators elucidated an accelerated aging rate. The studies were performed with the help of SF-36 inquirer and indicated that health status aggravation of the liquidators also affected their life satisfaction. The "life quality" indices of the liquidators significantly concede the overall average standards by both physical health and psychical and social welfare scales.
authors.forename: N M
authors.initials: NM
authors.lastname: Oganesian
authors.forename: N R
authors.initials: NR
authors.lastname: Davidian
authors.forename: E G
authors.initials: EG
authors.lastname: Gevorkian
authors.forename: A G
authors.initials: AG
authors.lastname: Karapetian
authors.forename: M I
authors.initials: MI
authors.lastname: Miridzhanian
authors.forename: K V
authors.initials: KV
authors.lastname: Asrian
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000528:radiation effects*; D001136:Armenia; D016022:Case-Control Studies; D047852:Chernobyl Nuclear Accident; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011788:Quality of Life; D011832:Radiation Injuries / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D013997:Time Factors; D014455:Ukraine; D055815:Young Adult