title: Incidence of Trypanosoma cruzi transmission through breastfeeding during acute experimental Chagas disease.
abstract: OBJECTIVE
  To verify the incidence of T. cruzi transmission through breastfeeding during acute experimental Chagas' disease.
  
  
  METHODS
  Fifteen female Swiss mice were mated and, after pregnancy confirmation, placed in individual cages. A few hours after birth, the females were inoculated with 0.1 mL of blood containing approximately 3 x 10(5) trypomastigote forms of Y strain of T. cruzi and continued breastfeeding for 25 days.
  
  
  RESULTS
  In 142 offspring examined no infection through breast-feeding was observed.
  
  
  CONCLUSIONS
  The low number of trypomastigote forms ingested by the newborn mice combined with biological and biochemical characteristics of blood trypomastigotes may explain the lack of transmission in this experiment.
authors.affiliation: Faculdade de Medicina de Marília, Rua Dona Maria Feres, 165 Bairro Fragata Marilia, SP, Brazil. luciapam@famema.br
authors.forename: Luciamare Perinetti Alves
authors.initials: LP
authors.lastname: Martins
authors.forename: Roberto Esteves Pires
authors.initials: RE
authors.lastname: Castanho
authors.forename: Adriano Barbosa
authors.initials: AB
authors.lastname: Nogueira
authors.forename: Otavio Turolo da
authors.initials: OT
authors.lastname: Silva
authors.forename: Alex Silva de
authors.initials: AS
authors.lastname: Gusmão
mesh_terms: D000208:Acute Disease; D000818:Animals; D001942:Breast Feeding / Q000009:adverse effects*; D014355:Chagas Disease / Q000635:transmission*; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000469:parasitology*