title: Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults: a translational study.
abstract: BACKGROUND
  Despite oxidized low density lipoprotein (ox-LDL) plays important roles in the pro-inflammatory and atherosclerotic processes, the relationships with metabolic and oxidative stress biomarkers have been only scarcely investigated in young adult people. Thus, the aim of this study was to assess plasma ox-LDL concentrations and the potential association with oxidative stress markers as well as with anthropometric and metabolic features in healthy young adults.
  
  
  METHODS
  This study enrolled 160 healthy subjects (92 women/68 men; 23±4 y; 22.0±2.9 kg/m2). Anthropometry, body composition, blood pressure, lifestyle features, biochemical data, and oxidative stress markers were assessed with validated tools. Selenium, copper, and zinc nail concentrations were measured by atomic absorption spectrophotometry.
  
  
  RESULTS
  Total cholesterol (TC), LDL-c and uric acid concentrations, TC-to-HDL-c ratio, and glutathione peroxidase (GPx) activity were positive predictors of ox-LDL concentrations, while nail selenium level (NSL) was a negative predictor, independently of gender, age, smoking status, physical activity. Those individuals included in the highest tertile of GPx activity (≥611 nmol/[mL/min]) and of NSL (≥430 ng/g of nail) had higher and lower ox-LDL concentrations, respectively, independently of the same covariates plus truncal fat or body mass index, and total cholesterol or LDL-c concentrations.
  
  
  CONCLUSIONS
  Ox-LDL concentrations were significantly associated with lipid biomarkers, GPx activity, uric acid concentration, and NSL, independently of different assayed covariates, in young healthy adults. These findings jointly suggest the early and complex relationship between lipid profile and redox status balance.
authors.affiliation: Nutrition Center, Federal University of Sergipe, Aracaju, Brazil.
authors.forename: Kiriaque B F
authors.initials: KB
authors.lastname: Barbosa
authors.forename: Ana Carolina P
authors.initials: AC
authors.lastname: Volp
authors.forename: Helen Hermana M
authors.initials: HH
authors.lastname: Hermsdorff
authors.forename: Iñigo
authors.initials: I
authors.lastname: Navarro-Blasco
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Zulet
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martínez
authors.forename: Josefina
authors.initials: J
authors.lastname: Bressan
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006262:Health; D006801:Humans; D008019:Life Style; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D015999:Multivariate Analysis; D009262:Nails / Q000378:metabolism; D018384:Oxidative Stress; D012643:Selenium / Q000378:metabolism; D057170:Translational Research, Biomedical; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008055:Lipids; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D005979:Glutathione Peroxidase; D012643:Selenium