title: Metachromins U-W: cytotoxic merosesquiterpenoids from an Australian specimen of the sponge Thorecta reticulata.
abstract: Three new merosesquiterpenoids, metachromins U, V, and W (1-3), were isolated from a specimen of the marine sponge Thorecta reticulata collected off Hunter Island, Tasmania, Australia. Structures of the new compounds were elucidated through extensive NMR investigations and comparison with literature values. The cytotoxicities of 1-3 were assessed against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a mammalian cell line (CHO-K1). All compounds were found to have 50% growth inhibition activities in the range 2.1-130 μM, with 2 being the most active (GI50 2.1-10 μM).
authors.affiliation: Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville, QLD 4810, Australia.
authors.forename: Simon P B
authors.initials: SP
authors.lastname: Ovenden
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Nielson
authors.forename: Catherine H
authors.initials: CH
authors.lastname: Liptrot
authors.forename: Richard H
authors.initials: RH
authors.lastname: Willis
authors.forename: Dianne M
authors.initials: DM
authors.lastname: Tapiolas
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wright
authors.forename: Cherie A
authors.initials: CA
authors.lastname: Motti
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C560322:metachromin U; C560323:metachromin V; C560324:metachromin W