title: Mitochondrial regulation of cell death in the Drosophila ovary.
abstract: Interactions between the Bcl-2 family proteins and the mitochondrial fission and fusion machinery regulate cell death in mammals and worms. In Drosophila, the Bcl-2 family proteins have not been shown to be major regulators of cell death. However, emerging evidence suggests that mitochondrial remodeling may be important in Drosophila cell death. We recently demonstrated a series of events that occur during follicle removal in the Drosophila ovary that included mitochondrial remodeling and clustering, followed by uptake and degradation in the follicle cells. Importantly, the Bcl-2 family proteins, mitochondrial dynamics, and autophagic proteins regulate these events.
authors.affiliation: Department of Biology, Boston University, Boston, MA, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Tanner
authors.forename: Kim
authors.initials: K
authors.lastname: McCall
mesh_terms: D000818:Animals; D016923:Cell Death; D004330:Drosophila / Q000166:cytology* / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism; D005260:Female; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D009866:Oogenesis; D010053:Ovary / Q000166:cytology* / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins