title: IL-10 promoter genetic polymorphisms and risk of Kawasaki disease in Taiwan.
abstract: Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the association between genetic variants in IL-10 promoter (-1082, -819, and -592) and risk of KD. A total of 134 trios were included for the family-based association study. A significantly preferential transmission of the C allele at loci -819 T > C and -592 A > C for KD cases was observed (P permutation = 0.029 and P permutation = 0.034, respectively). There was a significant increase in the transmission of haplotype CC (p = 0.016) at the above two loci (OR, 1.632; 95% CI, 1.090-2.443; P permutation = 0.019). We also carried out a follow-up case-control study that included 146 KD cases and 315 unrelated healthy children. The haplotype CC (-819, -592) showed an increased risk of KD (but statistically non-significant; OR, 1.332; 95% CI, 0.987-1.797; p = 0.061). In diplotype analysis, a trend was found between number of CC haplotype and risk of KD (but non-significant, p =0.061). In conclusion, CC genotype and CC/CC diplotype at IL-10-819T > C and -592A > C were significantly associated with risk of KD in case-parent trio study, which were replicated partially in our follow-up case-control study.
authors.affiliation: Department of Pediatric Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Kai-Sheng
authors.initials: KS
authors.lastname: Hsieh
authors.forename: Tsung-Jen
authors.initials: TJ
authors.lastname: Lai
authors.forename: Yu-Tung
authors.initials: YT
authors.lastname: Hwang
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Lin
authors.forename: Ken-Pen
authors.initials: KP
authors.lastname: Weng
authors.forename: Yi-Ten
authors.initials: YT
authors.lastname: Chiu
authors.forename: Tsyr-Yuh
authors.initials: TY
authors.lastname: Ho
authors.forename: Chi-Shan
authors.initials: CS
authors.lastname: Chen
authors.forename: Yow-Ling
authors.initials: YL
authors.lastname: Shiue
authors.forename: Michael
authors.initials: M
authors.lastname: Hsiao
authors.forename: Shih-Feng
authors.initials: SF
authors.lastname: Tsai
authors.forename: Luo-Ping
authors.initials: LP
authors.lastname: Ger
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D056726:Genetic Association Studies; D006239:Haplotypes; D040941:Heredity; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D013624:Taiwan
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10