title: Glucose transporter expression of intraductal papilloma of the breast detected by fluorodeoxyglucose positron emission tomography.
abstract: A 40-year-old woman discovered through palpation a tumor in the upper lateral quadrant of the left mammary gland. Mammography, ultrasonography (US), and magnetic resonance imaging (MRI) showed a 10 mm diameter tumor. Fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) showed abnormal accumulation in the detected tumor, and the maximum standardized uptake value was 2.2. The patient underwent tumor resection. The postoperative histopathological finding was intraductal papilloma. The intraductal papilloma showed strong expression of glucose transporter (GLUT)-4 on membrane and/or cytoplasm, and weak expression of GLUT-1 and GLUT-3 by immunohistochemistry. This case suggests that other glucose transporters (e.g., GLUT-4), other pathological factors, and cytokines may have a close relation with (18)F-FDG accumulation in intraductal papilloma more than GLUT-1 or GLUT-3 expression.
authors.affiliation: Division of Nuclear Medicine, PET Center and Department of Radiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume 830-0011, Japan.
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hayato
authors.initials: H
authors.lastname: Kaida
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ishibashi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawahara
authors.forename: Maiko
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Naofumi
authors.initials: N
authors.lastname: Hayabuchi
mesh_terms: D000328:Adult; D001940:Breast / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D018300:Papilloma, Intraductal / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000601:surgery; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed; D016217:Ultrasonography, Mammary
chemical_list: D051246:Glucose Transport Proteins, Facilitative; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18