title: Synthesis of functionalized ellipticinium and ellipticine derivatives via electrophilic cyclization.
abstract: An efficient methodology for the synthesis of highly functionalized ellipticinium and ellipticine derivatives starting from the corresponding 2-bromocarbazoles via an AgOTf or CuI catalyzed electrophilic cyclization of 2-alkynyl-3-carbazolylaldimines is reported.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad 500046, India.
authors.forename: T Krishna
authors.initials: TK
authors.lastname: Chaitanya
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Nagarajan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003500:Cyclization; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004611:Ellipticines / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D059005:Topoisomerase II Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004611:Ellipticines; D059005:Topoisomerase II Inhibitors; D004250:DNA Topoisomerases, Type II