title: Meningoencephalitis Due to HIV Replication Despite Plasmatic Viral Control.
abstract: We report a symptomatic case of HIV replication in CSF (Cerebro Spinal Fluid) despite low plasmatic viral load. The patient, known HIV positive since 3 years, under HAART (Highly Active Antiretroviral therapy), presented an acute meningoencephalitis which was improved by optimization of treatment for a better CNS (Central Nervous System) penetration according to the CHARTER's (CNS HIV Antiretroviral Therapy Effects Research) score. CNS can be considered as a specific compartment for HIV replication and can be involved in acute or chronic neurologic impairment. As showed in this observation, CHARTER score could be helpful to optimize HAART penetration in CNS, but indication and use remain uncertain in current practice.
authors.affiliation: 1 Infectious Diseases Unit, Raymond Poincaré University Hospital, AP-HP, University Versailles Saint Quentin, Garches, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Dinh
authors.forename: Jérôme
authors.initials: J
authors.lastname: Salomon
authors.forename: Damien Le
authors.initials: DL
authors.lastname: Du
authors.forename: Dominique
authors.initials: D
authors.lastname: Mathez
authors.forename: Robert
authors.initials: R
authors.lastname: Carlier
authors.forename: Louis
authors.initials: L
authors.lastname: Bernard
authors.forename: Pierre de
authors.initials: Pd
authors.lastname: Truchis
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1; D006801:Humans; D008590:Meningoencephalitis; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents