title: [Nasopharyngeal carriage of pneumococcal serotypes in healthy pre-school aged children after 7-valent pneumococcal vaccine].
abstract: OBJECTIVE
  To determine the characteristics influencing pneumococcal serotype colonization in healthy pre-school aged children, the distribution of serotypes and their antimicrobial susceptibility, after the introduction of pneumococcal 7-valent conjugate vaccine (VNC-7 v). SUJETOS AND METHODS: Nasopharyngeal samples were collected from children under 6 years of age attending well-child examinations in the province of Zaragoza (Spain). Logistic regression was used to study different variables related to the status of the carriers.
  
  
  RESULTS
  Of the 371 children studied 30.7% were found to be carriers. With a vaccine coverage rate of 66%, factors related with presence of pneumococcal carriage were found to be the number of siblings (OR 1.44; CI 95% 1.05-1.97 for each sibling), attending a school or child day care centre (OR 3.99; CI 95% 2.00-7.96) and suffering from a minor upper respiratory tract infection (URTI) (OR 1.72; CI 95% 1.02-2.90). Only 8.7% corresponded to VNC-7 v serotypes. The most common non VNC-7 v serotypes isolated were 19A, 6A, 15B, 11, and 15A. Significantly greater resistance was detected among VNC-7 v serotypes.
  
  
  CONCLUSIONS
  Children in the setting of this study carried pneumococci more commonly when they have siblings, attend school or day care, or suffer from minor URTI. In the VNC-7 v vaccine era, VNC-7 v serotypes have become rare occurrences (8.7%) and emerging serotypes present better susceptibility to antibiotics.
authors.affiliation: Centro de Salud J.R. Muñoz Fernández, Zaragoza, España. cgarciavera@gmail.com
authors.forename: César
authors.initials: C
authors.lastname: García-Vera
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: Ruiz Andrés
authors.forename: Teresa
authors.initials: T
authors.lastname: Arana Navarro
authors.forename: Isabel
authors.initials: I
authors.lastname: Moneo Hernández
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Castillo Laita
authors.forename: Rosa
authors.initials: R
authors.lastname: Macipe Costa
authors.forename: María José
authors.initials: MJ
authors.lastname: Revillo Pinilla
mesh_terms: D002353:Carrier State; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D009666:Nose / Q000382:microbiology*; D010614:Pharynx / Q000382:microbiology*; D022242:Pneumococcal Vaccines; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects; D018074:Vaccines, Conjugate
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate