title: Cell and gene therapy for bone repair.
abstract: Improving bone repair remains an important and challenging issue. Therapeutic approaches to amplify osteogenic cell pool or function include cell and gene therapies. We identified genes that promote human mesenchymal cell differentiation and bone formation. Targeting these or other genes may improve the efficacy of cell therapy for bone repair.
authors.affiliation: Laboratory of Osteoblast Biology and Pathology, Inserm UMR606 and University Paris Diderot, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris cedex 10, France. pierre.marie@inserm.fr
authors.forename: P J
authors.initials: PJ
authors.lastname: Marie
mesh_terms: D001861:Bone Regeneration / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology; D010012:Osteogenesis / Q000235:genetics / Q000502:physiology