title: Suicide in a large population of former psychiatric inpatients.
abstract: OBJECTIVE
  The aim of this study was to identify predictors of completed suicide in a wide sample of psychiatric inpatients receiving retrospective and prospective DSM-IV diagnoses.
  
  
  METHODS
  We followed up 4441 severe psychiatric patients who were hospitalized for some time during a 35-year period in a private hospital setting. We collected sociodemographic, clinical and temperamental data.
  
  
  RESULTS
  Ninety-six patients from the sample committed suicide. There were no sex differences in suicide completion and no differences between major psychiatric disorders, but people who had been hospitalized for anxiety disorders did not commit suicide and people with bipolar disorders were more likely to commit suicide than people with unipolar major depression. Shorter-term treatment with lithium and anticonvulsants, longer-term treatment with antidepressants, history of suicide attempts, suicidal thinking, and single status positively predicted completed suicide. Suicide tended to occur after a mean period of about 14 years of duration of disease. Patients' symptoms during the period preceding suicide were assessed through interviewing patients' physicians or family members. Symptoms occurring in >10% of cases were, in decreasing order, inner tension, racing/crowded thoughts, aggressive behavior, guilt, psychomotor agitation, persecutory ideation, anxiety, and hallucinations. Surprisingly, cyclothymic temperament was less associated with completed suicide as compared to other temperaments.
  
  
  CONCLUSIONS
  Suicide is likely to occur in a milieu of agitation, mixed anxiety and depression, and psychosis. Longer-term mood stabilizer treatment may reduce the rate of completed suicide.
authors.affiliation: Centro Lucio Bini, Rome, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Sani
authors.forename: Leonardo
authors.initials: L
authors.lastname: Tondo
authors.forename: Athanasios
authors.initials: A
authors.lastname: Koukopoulos
authors.forename: Daniela
authors.initials: D
authors.lastname: Reginaldi
authors.forename: Giorgio D
authors.initials: GD
authors.lastname: Kotzalidis
authors.forename: Alexia E
authors.initials: AE
authors.lastname: Koukopoulos
authors.forename: Giovanni
authors.initials: G
authors.lastname: Manfredi
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Mazzarini
authors.forename: Isabella
authors.initials: I
authors.lastname: Pacchiarotti
authors.forename: Alessio
authors.initials: A
authors.lastname: Simonetti
authors.forename: Elisa
authors.initials: E
authors.lastname: Ambrosi
authors.forename: Gloria
authors.initials: G
authors.lastname: Angeletti
authors.forename: Paolo
authors.initials: P
authors.lastname: Girardi
authors.forename: Roberto
authors.initials: R
authors.lastname: Tatarelli
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007297:Inpatients / Q000523:psychology*; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors; D012727:Sex Characteristics; D013405:Suicide / Q000523:psychology* / Q000706:statistics & numerical data
chemical_list: D011619:Psychotropic Drugs