title: Nuclear delivery mechanism of herpes simplex virus type 1 genome.
abstract: Herpes simplex virus type 1 (HSV-1) is a widespread human pathogen infecting more than 80% of the population worldwide. Its replication involves an essential, poorly understood multistep process, referred to as uncoating. Uncoating steps are as follows: (1) The incoming capsid pinpoints the nuclear pore complex (NPC). (2) It opens up at the NPC and releases the highly pressurized viral genome. (3) The viral genome translocates through the NPC. In the present review, we highlight recent advances in this field and propose mechanisms underlying the individual steps of uncoating. We presume that the incoming HSV-1 capsid pinpoints the NPC by hydrophobic interactions and opens up upon binding to NPC proteins. Genome translocation is initially pressure-driven.
authors.affiliation: Institute of Physiology II, University of Münster, Robert-Koch-Str. 27b, 48147 Münster, Germany.
authors.forename: Ivan
authors.initials: I
authors.lastname: Liashkovich
authors.forename: Wali
authors.initials: W
authors.lastname: Hafezi
authors.forename: Joachim M
authors.initials: JM
authors.lastname: Kühn
authors.forename: Hans
authors.initials: H
authors.lastname: Oberleithner
authors.forename: Victor
authors.initials: V
authors.lastname: Shahin
mesh_terms: D002213:Capsid / Q000378:metabolism; D016679:Genome, Viral / Q000235:genetics*; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D022022:Nuclear Pore / Q000378:metabolism