title: Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia.
abstract: Hypercholesterolemia is one of the most representative disorders of the common diseases. To evaluate the prevalence of hypothyroidism in the population of adult hypercholesterolemia, we prospectively examined the thyroid function in patients with untreated or treated hypercholesterolemia as a multi-center survey. Subjects were the patients who were treated with some antilipemic agents or the untreated patients whose total cholesterol (TC) was over 220 mg/dL and/or LDL-cholesterol (LDL-C) over 140 mg/dL. Among 737 cases recruited, 725 cases (300 males and 425 females) participated in the survey including the thyroid function test. The patient's backgrounds include hypertension (51%), diabetes mellitus (49%), fatty liver (17%), smoking (15%), and habitual drinking (10%). The 72% of the patients were treated with some antilipemic agents and the mean values of TC, LDL-C, triglyceride (TG), HDL-cholesterol (HDL-C), and LDL-C/HDL-C ratio (L/H) were 204.5 mg/dL, 119.6 mg/dL, 144.4 mg/dL, 60.7 mg/dL and 2.25, respectively. The primary hypothyroidism was seen in 27 cases (3.7%) (11 males, 16 females) with subclinical hypothyroidism in 17 cases (2.4%) and overt hypothyroidism in 10 cases (1.4%). The central hypothyroidism was seen in 4 cases (0.6%). The prevalence of hypothyroidism was 4.3% in patients with hypercholesterolemia. Taking account of the large number of patients with dyslipidemia and importance of avoiding unnecessary administration and associated adverse effects, evaluation of the thyroid function could be warranted in patients with dyslipidemia although cost-benefit issues waits further investigation.
authors.affiliation: Clinical Research Institute, Division of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan. ttagami@kyotolan.hosp.go.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tagami
authors.forename: Hironori
authors.initials: H
authors.lastname: Kimura
authors.forename: Sumire
authors.initials: S
authors.lastname: Ohtani
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Shiro
authors.initials: S
authors.lastname: Hata
authors.forename: Miho
authors.initials: M
authors.lastname: Saito
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Rika
authors.initials: R
authors.lastname: Araki
authors.forename: Masami
authors.initials: M
authors.lastname: Tanaka
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yonezawa
authors.forename: Morio
authors.initials: M
authors.lastname: Sawamura
authors.forename: Takuyuki
authors.initials: T
authors.lastname: Ise
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ogo
authors.forename: Takuro
authors.initials: T
authors.lastname: Shimbo
authors.forename: Akira
authors.initials: A
authors.lastname: Shimatsu
authors.forename: Mitsuhide
authors.initials: M
authors.lastname: Naruse
mesh_terms: D000328:Adult; D000368:Aged; D050171:Dyslipidemias / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007037:Hypothyroidism / Q000188:drug therapy / Q000453:epidemiology*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine