title: Successful treatment of adult onset Langerhans cell histiocytosis with multi-drug combination therapy.
abstract: Adult onset Langerhans cell histiocytosis (LCH) is a rare disorder. Its clinical features have been well described in children, however remain poorly defined in adults. Optimal treatment strategy is still under debate. We have encountered two cases of adult onset LCH, which obtained a durable disease control by combination chemotherapy using prednisone, vinblastine and 6-mercaptopurine. Herein, we report their clinical features together with a review of the current literature.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Japan. erie@kk.iij4u.or.jp
authors.forename: Eri
authors.initials: E
authors.lastname: Matsuki
authors.forename: Yuiko
authors.initials: Y
authors.lastname: Tsukada
authors.forename: Aya
authors.initials: A
authors.lastname: Nakaya
authors.forename: Kenji
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Okamoto
mesh_terms: D000328:Adult; D017668:Age of Onset; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D014747:Vinblastine; D015122:Mercaptopurine; D011241:Prednisone