title: Normal fasting plasma glucose and risk of type 2 diabetes.
abstract: OBJECTIVE
  To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes.
  
  
  METHODS
  Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors.
  
  
  RESULTS
  During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The final model demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL.
  
  
  CONCLUSIONS
  Our data suggest that FPG between 91 and 99 mg/dL is a strong independent predictor of type 2 diabetes and should be used to identify people to be further investigated and aided with preventive measures.
authors.affiliation: University Department of Laboratory Medicine, University Milano Bicocca, Hospital of Desio, Milano, Italy. paolo.brambilla@uds.unimib.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Brambilla
authors.forename: Elisa
authors.initials: E
authors.lastname: La Valle
authors.forename: Rosanna
authors.initials: R
authors.lastname: Falbo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Limonta
authors.forename: Stefano
authors.initials: S
authors.lastname: Signorini
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Cappellini
authors.forename: Paolo
authors.initials: P
authors.lastname: Mocarelli
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012306:Risk
chemical_list: D001786:Blood Glucose