title: Dysfunctional attitudes and the serotonin transporter promoter polymorphism (5-HTTLPR).
abstract: Dysfunctional attitudes may be one phenotype by which genes increase risk for depression. Building on research demonstrating associations between serotonin abnormalities and dysfunctional attitudes, we examined the covariation between dysfunctional attitudes and the serotonin transporter gene-linked polymorphic region (5-HTTLPR). In a sample of nondepressed young adults (N=131), people with one or two copies of the low-expressing alleles reported stronger endorsement of dysfunctional attitudes regarding performance evaluation than people who were homozygous for the high-expressing alleles; there was no association between the 5-HTTLPR polymorphism and dysfunctional attitudes regarding approval by others. These results add to the literature linking the 5-HTTLPR polymorphism and cognitive vulnerabilities for depression.
authors.affiliation: University of Colorado at Boulder, Department of Psychology and Neuroscience, Boulder, CO 80309-0345, USA. mark.whisman@colorado.edu
authors.forename: Mark A
authors.initials: MA
authors.lastname: Whisman
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Johnson
authors.forename: Andrew
authors.initials: A
authors.lastname: Smolen
mesh_terms: D000293:Adolescent; D000483:Alleles; D000704:Analysis of Variance; D001290:Attitude; D003863:Depression / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins