title: Diagnostic utility of enzyme-linked immunospot assay for interferon-γ in a patient with tuberculous arthritis and pyomyositis.
abstract: The indolent and nonspecific presentations of tuberculous arthritis and pyomyositis render their diagnosis a great challenge for clinicians. We describe a 78-year-old man with swelling and pain of right knee for 6 months. The patient was empirically treated for tuberculosis because positive enzyme-linked immunospot assay for interferon-γ of blood was reported at 2 days after aspiration of synovial fluid, which was negative for acid-fast stain but subsequently grew Mycobacterium tuberculosis 6 weeks later. He recovered uneventfully with 1-year antituberculous combination therapy.
authors.affiliation: Department of Intensive Care Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Che-Kim
authors.initials: CK
authors.lastname: Tan
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Lai
authors.forename: Sheng-Hsiang
authors.initials: SH
authors.lastname: Lin
authors.forename: Yu-Tsung
authors.initials: YT
authors.lastname: Huang
authors.forename: Chun-Hsing
authors.initials: CH
authors.lastname: Liao
authors.forename: Po-Ren
authors.initials: PR
authors.lastname: Hsueh
mesh_terms: D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage; D019411:Clinical Laboratory Techniques / Q000379:methods*; D058501:Enzyme-Linked Immunospot Assay / Q000379:methods*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000302:isolation & purification*; D052880:Pyomyositis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D011859:Radiography; D016896:Treatment Outcome; D014394:Tuberculosis, Osteoarticular / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology
chemical_list: D000995:Antitubercular Agents; D007371:Interferon-gamma