title: Cyanine dyes as optical contrast agents for ophthalmological surgery.
abstract: Cyanine dyes were prepared as optical contrast media for supporting the surgery of the lamina limitans interna (LLI) of the retina and other structures of the human eye. Their absorption spectra were adapted both to the spectral sensitivity of the human eye and to standard illumination. The contrast could be further amplified by the application of the strong fluorescence of the dyes used. The binding of the dyes to various surfaces was studied. No toxic effects could be detected for the applied dyes.
authors.affiliation: Department of Chemisty, LMU University of Munich, Butenandtstrasse 13, Munich, Germany. Langhals@lrz.uni-muenchen.de
authors.forename: Heinz
authors.initials: H
authors.lastname: Langhals
authors.forename: Ana
authors.initials: A
authors.lastname: Varja
authors.forename: Peter
authors.initials: P
authors.lastname: Laubichler
authors.forename: Marcus
authors.initials: M
authors.lastname: Kernt
authors.forename: Kirsten
authors.initials: K
authors.lastname: Eibl
authors.forename: Christos
authors.initials: C
authors.lastname: Haritoglou
mesh_terms: D000818:Animals; D002232:Carbocyanines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D015394:Molecular Structure; D013508:Ophthalmologic Surgical Procedures; D011485:Protein Binding; D012160:Retina / Q000601:surgery*; D013552:Swine
chemical_list: C560301:3,3'-di-(2-carboxyethyl)-1,1,1',1'-tetramethyl-1H-disulfobenz(e)indocarbocyanin; D002232:Carbocyanines; D003287:Contrast Media; D005456:Fluorescent Dyes