title: Effectiveness of vital staining with iodine solution in reducing local recurrence after resection of dysplastic or malignant oral mucosa.
abstract: The purpose of this retrospective study was to assess the effect of vital staining with iodine solution in reducing local recurrence after resection of dysplastic or malignant oral mucosa. The historical control group had dysplastic or malignant mucosal lesions resected solely on the evidence of direct inspection and palpation. In the vital staining group tissue was resected only after vital staining with iodine solution. Seven of 25 patients in the conventional group developed recurrent dysplastic or cancerous oral mucosa around the primary site, while no patient among 23 reported recurrence in the vital staining group (p<0.01). Kaplan-Meier assessment showed that the 5-year primary control rate was 100% in the vital staining group and 75% in the conventional group. Although this retrospective study has some limitations, the results suggest that vital staining with iodine may be useful in reducing the incidence of recurrence of dysplastic or cancerous epithelium at a primary site. Further well-controlled study is essential.
authors.affiliation: Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumato 390-8621, Japan. hkurita@shinshu-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurita
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kamata
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Li
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Tetsu
authors.initials: T
authors.lastname: Shimane
authors.forename: Takeshi
authors.initials: T
authors.lastname: Koike
mesh_terms: D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007454:Iodides / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology / Q000601:surgery*; D009062:Mouth Neoplasms / Q000473:pathology / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D019647:Oral Surgical Procedures; D012189:Retrospective Studies
chemical_list: D000891:Anti-Infective Agents, Local; D007454:Iodides; C010389:Lugol's solution