title: Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles.
abstract: Amino acid-derived propargylic amides are cyclised in a one-pot, Au(III)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323, Harry Hines Blvd., Dallas, Texas 75390, USA.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Paradise
authors.forename: Pooja R
authors.initials: PR
authors.lastname: Sarkar
authors.forename: Mina
authors.initials: M
authors.lastname: Razzak
authors.forename: Jef K
authors.initials: JK
authors.lastname: De Brabander
mesh_terms: D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000596:Amino Acids; D010080:Oxazoles; D006046:Gold