title: [Treatment of ischemia-reperfusion injury of flap].
abstract: OBJECTIVE
  To review the treatment methods and techniques of ischemia-reperfusion injury of flap.
  
  
  METHODS
  Recent basic research literature concerning ischemia-reperfusion injury of flap was reviewed and analyzed in terms of treatment techniques.
  
  
  RESULTS
  Ischemia-reperfusion injury is one of the leading causes of flap necrosis postoperatively. Interventions against any link of the ischemia-reperfusion injury progress could effectively reduce the damage and improve the survival rate of flaps.
  
  
  CONCLUSIONS
  Including production of reactive oxygen species, neutrophil infiltration etc are thought to be the main mechanisms of ischemia-reperfusion injury. Treatment including medicine administration and physical intervention against any specific link of ischemia-reperfusion injury can interfere or block the whole progress, which reduce the damage of ischemia-reperfusion injury and improve the survival rate of animal flap models eventually.
authors.affiliation: Department of Orthopedics, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R.China.
authors.forename: Wenqi
authors.initials: W
authors.lastname: Gu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yimin
authors.initials: Y
authors.lastname: Chai
mesh_terms: D000818:Animals; D006801:Humans; D009336:Necrosis; D015427:Reperfusion Injury / Q000628:therapy*; D013524:Surgical Flaps / Q000098:blood supply*