title: Local delivery strategies in epilepsy: a focus on adenosine.
abstract: Local delivery of compounds directly into the brain may become an attractive treatment option for several neurological diseases. Higher therapeutic drug levels may be reached at the targeted brain region and in this way systemic side effects avoided. This paper provides an overview of the currently investigated experimental and clinical local delivery strategies in the brain ranging from delivery via pump mechanisms to more advanced techniques with cell and gene therapy. The second part focuses on local brain delivery strategies for epilepsy with special attention to adenosine. Adenosine is a good candidate for local delivery techniques for epilepsy because of its proven anticonvulsive effect and it cannot be given systemically because of systemic side effects. An overview of the current published studies with local delivery of adenosine is given.
authors.affiliation: Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Gent University Hospital, Belgium. Annelies.VanDycke@UGent.be
authors.forename: Annelies
authors.initials: A
authors.lastname: Van Dycke
authors.forename: Robrecht
authors.initials: R
authors.lastname: Raedt
authors.forename: Kristl
authors.initials: K
authors.lastname: Vonck
authors.forename: Paul
authors.initials: P
authors.lastname: Boon
mesh_terms: D000241:Adenosine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D004827:Epilepsy / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans
chemical_list: D000241:Adenosine