title: Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method.
abstract: A series of novel N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives has been synthesized. All the newly synthesized compounds were evaluated for their anti-HIV activity using MTT method. Most of these compounds showed moderate to potent activity against wild-type HIV-1 with an EC(50) ranging from >7 EC(50) [μg/ml] to <100 EC(50) [μg/ml]. Among them, N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide 6v was identified as the most promising compound (EC(50)=<7 μg/ml). Among all the compounds, three compounds 6m, 6v and 6u have been exhibits potent anti-HIV activity against MT-4 cells.
authors.affiliation: Department of Chemistry, Saurashtra University, Rajkot 360005, India.
authors.forename: Dhairya
authors.initials: D
authors.lastname: Bhavsar
authors.forename: Jalpa
authors.initials: J
authors.lastname: Trivedi
authors.forename: Shrey
authors.initials: S
authors.lastname: Parekh
authors.forename: Mahesh
authors.initials: M
authors.lastname: Savant
authors.forename: Shailesh
authors.initials: S
authors.lastname: Thakrar
authors.forename: Abhay
authors.initials: A
authors.lastname: Bavishi
authors.forename: Ashish
authors.initials: A
authors.lastname: Radadiya
authors.forename: Hardevsinh
authors.initials: H
authors.lastname: Vala
authors.forename: Jignesh
authors.initials: J
authors.lastname: Lunagariya
authors.forename: Manisha
authors.initials: M
authors.lastname: Parmar
authors.forename: Ladwa
authors.initials: L
authors.lastname: Paresh
authors.forename: Roberta
authors.initials: R
authors.lastname: Loddo
authors.forename: Anamik
authors.initials: A
authors.lastname: Shah
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D044966:Anti-Retroviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure
chemical_list: D000081:Acetamides; D044966:Anti-Retroviral Agents; D001578:Benzopyrans; D052160:Benzothiazoles