title: [Effect of ghrelin on duodenal migrating myoelectric complex in rats with chronic renal failure].
abstract: OBJECTIVE
  To investigate the effect of ghrelin on duodenal migrating myoelectric complex (MMC) in rats with chronic renal failure (CRF).
  
  
  METHODS
  Thirty healthy male SD rats were randomly assigned into sham-operated group (n=6) and CRF group (n=24), and the latter group was divided into 4 subgroups according to ghrelin doses administered with or without pretreatment with the receptor antagonist D-Lys(3)-GHRP-6. After a 18-h fasting, the rats with or without pretreatment with D-Lys(3)-GHRP-6 were given subcutaneous injections of ghrelin at different doses to observe the changes in duodenal MMC recorded using a multi lead physiological recording system.
  
  
  RESULTS
  Ghrelin significantly increased the MMC cycle duration and dose-dependently enhanced the frequency, amplitude and percentage of phase III MMC cycle. This effect was inhibited by the pretreatment with ghrelin receptor antagonist D-Lys(3)-GHRP-6.
  
  
  CONCLUSIONS
  Ghrelin can promote gastrointestinal motilities of rats with CRF, and the receptor of ghrelin can regulate the activity of MMC.
authors.affiliation: Department of Nephrology, Second Hospital of Xi an Jiaotong University, Xi an 710004, China. pipifu@126.com
authors.forename: Rong-Guo
authors.initials: RG
authors.lastname: Fu
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zhou
authors.forename: Gang-Lian
authors.initials: GL
authors.lastname: Yao
authors.forename: Yan
authors.initials: Y
authors.lastname: Ou
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: Qi
authors.forename: Bao-Song
authors.initials: BS
authors.lastname: Gui
mesh_terms: D000818:Animals; D004386:Duodenum / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D054439:Ghrelin / Q000494:pharmacology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D016065:Myoelectric Complex, Migrating; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D054439:Ghrelin