title: Improvement of catalytic properties of Candida rugosa lipase by sol-gel encapsulation in the presence of magnetic calix[4]arene nanoparticles.
abstract: Candida rugosa lipase (CRL) was encapsulated within a chemically inert sol-gel support prepared by polycondensation with tetraethoxysilane (TEOS) and octyltriethoxysilane (OTES) in the presence of N-methylglucamine based calix[4]arene magnetic nanoparticles. The results indicate that the magnetic calix[4]arene based encapsulated lipase particularly has shown high conversion and enantioselectivity. It has also been noticed that the magnetic calix[4]arene based encapsulated lipase has excellent enantioselectivity (E = 460) as compared to the free enzyme (E = 166) with an ee value of >98% for S-Naproxen.
authors.affiliation: Department of Chemistry, Selcuk University, Konya, 42075, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Sayin
authors.forename: Elif
authors.initials: E
authors.lastname: Yilmaz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yilmaz
mesh_terms: D055162:Biocatalysis; D047250:Calixarenes / Q000737:chemistry*; D002175:Candida / Q000201:enzymology*; D005290:Ferric Compounds / Q000737:chemistry; D005782:Gels / Q000138:chemical synthesis / Q000737:chemistry; D008049:Lipase / Q000737:chemistry / Q000378:metabolism*; D008280:Magnetics; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010636:Phenols / Q000737:chemistry*; D013237:Stereoisomerism; D013499:Surface Properties
chemical_list: D005290:Ferric Compounds; D005782:Gels; D010636:Phenols; C121325:calix(4)arene; D047250:Calixarenes; C000499:ferric oxide; D008049:Lipase