title: Paullones as inhibitors of protein kinases.
abstract: Paullones are a class of molecules structurally based on the 7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one parent scaffold. Many of these structures are inhibitors of certain protein kinases, namely cyclin-dependent kinases and glycogen synthase kinase-3. Being well referenced in the literature on the one hand and commercially available on the other hand, paullones have been used as biochemical tools in basic research and drug development for more than a decade. This review gives an overview over the published reports regarding chemistry, biological activity and pharmacological applications of paullone derivatives.
authors.affiliation: Technische Universität Braunchweig, Institut für Pharmazeutische Chemie, Braunschweig, Germany.
authors.forename: Nadine
authors.initials: N
authors.lastname: Tolle
authors.forename: Conrad
authors.initials: C
authors.lastname: Kunick
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011494:Protein Kinases / Q000378:metabolism*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D001552:Benzazepines; D047428:Protein Kinase Inhibitors; C547599:paullone; D011494:Protein Kinases