title: MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11.
abstract: MicroRNAs are widely dysregulated in various cancers and integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. Here, we show that miR-26b, which is down-regulated in human breast cancer specimens and cell lines, impairs viability and triggers apoptosis of human breast cancer MCF7 cells. SLC7A11 is identified as a direct target of miR-26b and its expression is remarkably increased in both breast cancer cell lines and clinical samples. Furthermore, SLC7A11 silence mimics miR-26b-aroused viability impairment and apoptosis in MCF7 cells. Our studies reveal a protective role of miR-26b in the molecular etiology of human breast cancer by promoting apoptosis.
authors.affiliation: Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Chinese Academy of Sciences (CAS), Shanghai, China.
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Liu
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Liang
authors.forename: Ci-Xiang
authors.initials: CX
authors.lastname: Zhou
authors.forename: Dan-Xia
authors.initials: DX
authors.lastname: Cao
authors.forename: Ming
authors.initials: M
authors.lastname: He
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Chen
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: He
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D027182:Amino Acid Transport System y+ / Q000235:genetics* / Q000378:metabolism; D017209:Apoptosis / Q000235:genetics*; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000235:genetics; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors
chemical_list: D027182:Amino Acid Transport System y+; D035683:MicroRNAs; C528163:MIRN26 microRNA, human; C118895:SLC7A11 protein, human