title: The effects of bromazepam over the temporo-parietal areas during the performance of a visuomotor task: a qEEG study.
abstract: This study investigated the effects of bromazepam on qEEG when 14 healthy subjects were asked to perform a visuomotor task (i.e., motor vehicle driving task). The subjects were exposed to two experimental conditions: the placebo (PL) and 6 mg of bromazepam (Br 6 mg), following a randomized, double-blind design on different days. Specifically, we observe absolute power extracted from qEEG data for theta band. We expected to see a decrease in absolute theta power in the temporal and parietal areas due to the influence of bromazepam for the experimental group when compared with the placebo group. We found a main effect for the condition factor for electrodes T3, T4, P3 and P4. We also observed a main effect for the period factor for electrodes P3 and P4. We observed that the ingestion of 6 mg of bromazepam induces different patterns in theta power at the temporal and parietal sites. We concluded that 6 mg of bromazepam was an important factor in the fluctuation of the activities in the temporal and parietal areas. We then hypothesize about the specific role of this drug during the execution of a visuomotor task and within the sensorimotor integration process.
authors.affiliation: Brain Mapping and Sensory Motor Integration, Institute of Psychiatry of the Federal University of Rio de Janeiro (IPUB/UFRJ), Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Araújo
authors.forename: Sergio
authors.initials: S
authors.lastname: Machado
authors.forename: Flávia
authors.initials: F
authors.lastname: Paes
authors.forename: Marlo
authors.initials: M
authors.lastname: Cunha
authors.forename: Henning
authors.initials: H
authors.lastname: Budde
authors.forename: Mauricio
authors.initials: M
authors.lastname: Cagy
authors.forename: Luis F
authors.initials: LF
authors.lastname: Basile
authors.forename: Oscar
authors.initials: O
authors.lastname: Arias-Carrión
authors.forename: Bruna
authors.initials: B
authors.lastname: Velasques
authors.forename: Roberto
authors.initials: R
authors.lastname: Piedade
authors.forename: Pedro
authors.initials: P
authors.lastname: Ribeiro
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D001960:Bromazepam / Q000494:pharmacology*; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects* / Q000502:physiology; D005260:Female; D018757:GABA Modulators / Q000494:pharmacology; D006801:Humans; D008297:Male; D009068:Movement / Q000187:drug effects* / Q000502:physiology; D010296:Parietal Lobe / Q000187:drug effects* / Q000502:physiology; D013647:Task Performance and Analysis; D013702:Temporal Lobe / Q000187:drug effects* / Q000502:physiology; D014796:Visual Perception / Q000187:drug effects* / Q000502:physiology
chemical_list: D018757:GABA Modulators; D001960:Bromazepam