title: Use of laser phototherapy on a delayed wound healing of oral mucosa previously submitted to radiotherapy: case report.
abstract: Radiotherapy produces both acute and delayed effects on mucosal tissues, disturbing their healing. This report shows a successful treatment with laser phototherapy (LPT) on a delayed wound healing in oral mucosa previously submitted to radiotherapy with a follow up of 3 years. A 47-year-old patient treated 6 months earlier for tongue squamous cell carcinoma by surgery and radiotherapy presented with a mass in the operated area. Biopsy showed chronic inflammatory infiltrate around a residual polyglactin suture. After 2 months there was a painful mucosal dehiscence on the biopsy site. LPT was performed using a semiconductor laser with 660-nm wavelength (InGaAlP) and spot size of 0·04 cm(2) . The parameters applied were 40 mW, 4 Jcm(2) /point, 0·16 J/point, 2·4 J/session. The irradiation was performed punctually, through contact mode in 15 points (4 seconds/point), on top of and around the lesion, during ten sessions. The wound healed completely after ten sessions. This treatment proved to be conservative and effective, inducing healing of a chronic wound in a tissue previously submitted to radiotherapy.
authors.affiliation: Stomatology Department, School of Dentistry, University of São Paulo (USP), São Paulo, Brazil.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Ramalho
authors.forename: Ana C
authors.initials: AC
authors.lastname: Luiz
authors.forename: Carlos
authors.initials: C
authors.lastname: de Paula Eduardo
authors.forename: Jan
authors.initials: J
authors.lastname: Tunér
authors.forename: Roberto P
authors.initials: RP
authors.lastname: Magalhães
authors.forename: Marina
authors.initials: M
authors.lastname: Gallottini Magalhães
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000532:radiotherapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology / Q000528:radiation effects*; D019226:Oral Ulcer / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000473:pathology / Q000532:radiotherapy*; D013997:Time Factors; D014062:Tongue Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D014945:Wound Healing / Q000528:radiation effects*