title: [A hair prosthesis consisting of allogeneic hair and polypropylene mimicking follicular units: long-term result and histocompatibility in rabbits].
abstract: OBJECTIVE
  To develop a follicular unit-like construct with allogeneic hair, evaluate its histocompatibility and long-term stability after transplantation, and explore the possibility of its clinical application.
  
  
  METHODS
  Human hair and medical polypropylene was processed according to the structure of follicular units and prepared into hair prostheses for transplantation. The histocompatibility of polypropylene and human hair in New Zealand rabbits was observed by HE staining and scanning electron microscope, and the loss rate of the hair was recorded to evaluate the long-term result of transplantation.
  
  
  RESULTS
  Mild inflammatory cell infiltration around polypropylene and human hair was observed early after the transplantation, accompanied with local epithelial cell proliferation. The prosthesis mimicking the follicular units still showed good histocompatibility one year after the transplantation without degradation of the hair. The loss rate of the hair was averaged (4.1∓4.0)% at one year after the transplantation, and the total appearance of the prosthesis remained satisfactory.
  
  
  CONCLUSIONS
  Allogeneic human hair and polypropylene in the hair prosthesis show good histocompatibility in rabbits. The prosthesis allows good cosmetic effect after transplantation with low rate of hair loss, demonstrating its potential in clinical application.
authors.affiliation: Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. jiangxisunyu@sina.com
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Zhi-Qi
authors.initials: ZQ
authors.lastname: Hu
authors.forename: Chuan-Bo
authors.initials: CB
authors.lastname: Feng
authors.forename: Feng
authors.initials: F
authors.lastname: Lu
authors.forename: Ge
authors.initials: G
authors.lastname: Liu
authors.forename: Zhi-Dan
authors.initials: ZD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D006197:Hair / Q000637:transplantation*; D018859:Hair Follicle / Q000637:transplantation*; D006801:Humans; D008422:Materials Testing; D011126:Polypropylenes; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D011126:Polypropylenes