title: Vibration-response imaging versus quantitative perfusion scintigraphy in the selection of patients for lung-resection surgery.
abstract: BACKGROUND
  In patients being considered for lung-resection surgery, quantitative perfusion scintigraphy is used to predict postoperative lung function and guide the determination of lung-resection candidacy. Vibration-response imaging has been proposed as a noninvasive, radiation-free,  and simpler method to predict postoperative lung function. We compared vibration-response imaging to quantitative perfusion scintigraphy for predicting postoperative FEV(1) and diffusing capacity of the lung for carbon monoxide (D(LCO)).
  
  
  METHODS
  We enrolled 35 candidates  for lung resection. Twenty-five patients had preoperative FEV(1) and D(LCO) MEASUREMENTS:
  
  
  RESULTS
  The vibration-response-imaging measurements showed strong correlation with the quantitative-perfusion-scintigraphy measurements of predicted postoperative FEV(1)% (r  = 0.87, P < .001), predicted postoperative FEV(1) (r = 0.90, P < .001), and predicted postoperative D(LCO)% (r = 0.90, P < .001). There was a correlation between predicted postoperative FEV(1) (% and L) measured via quantitative perfusion  scintigraphy and the actual postoperative FEV(1) (% and L) (r = 0.47, P = .048, r = 0.73, P < .001). There was no difference between the vibration-response-imaging measurements and the actual postoperative measurements of predicted postoperative FEV(1) (%  and L). There was a correlation between predicted postoperative FEV(1) (% and L) measured via vibration-response imaging and actual postoperative FEV(1) (% and L) (r = 0.52, P = .044, r = 0.79, P < .001). The mean differences between the predicted and actual  postoperative FEV(1) values were 49 mL with vibration-response imaging, versus 230 mL with quantitative perfusion scintigraphy. Neither the vibration-response imaging nor the quantitative perfusion scintigraphy predicted postoperative D(LCO)% values agreed with the actual  postoperative D(LCO)% values.
  
  
  CONCLUSIONS
  Vibration-response imaging may be a good alternative to quantitative perfusion scintigraphy in evaluating lung-resection candidacy.
authors.affiliation: Department of Pulmonary Diseases, Istanbul University, Istanbul, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Comce
authors.forename: Zuleyha
authors.initials: Z
authors.lastname: Bingol
authors.forename: Esen
authors.initials: E
authors.lastname: Kiyan
authors.forename: Serhan
authors.initials: S
authors.lastname: Tanju
authors.forename: Alper
authors.initials: A
authors.lastname: Toker
authors.forename: Pembe
authors.initials: P
authors.lastname: Cagatay
authors.forename: Turhan
authors.initials: T
authors.lastname: Ece
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000601:surgery; D008875:Middle Aged; D018579:Patient Selection; D055420:Perfusion Imaging; D011013:Pneumonectomy; D011184:Postoperative Period; D011652:Pulmonary Circulation / Q000502:physiology; D011875:Radionuclide Angiography; D014732:Vibration