title: [Effective reversal of muscle relaxation by rocuronium using sugammadex in a patient with myasthenia gravis undergoing laparoscopic cholecystectomy].
abstract: As myasthenia gravis affects neuromuscular transmission, these patients show various responses to neuromuscular blocking drugs. We report a successful use of the sugammadex in a myasthenic patient to reverse rocuronium-induced neuromuscular block. A 69-year-old woman was scheduled for laparoscopic cholecystectomy and total of rocuronium 20 mg was administered. After spontaneous recovery of T1, we administered sugammadex 200mg intravenously, reversing neuromuscular blockade to a train-of-four ratio (T4/T1) of 100% within 30 sec. Sugammadex can be used to reverse rocuronium-induced neuromuscular blockade in patients with myasthenia gravis, thereby avoiding the need for reversal with acetylcholinesterase inhibitors.
authors.affiliation: Department of Anesthesiology, Takarazuka Municipal Hospital, Takarazuka 665-0827.
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Komasawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Noma
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugi
authors.forename: Norihiko
authors.initials: N
authors.lastname: Sukenaga
authors.forename: Hideki
authors.initials: H
authors.lastname: Kakiuchi
mesh_terms: D000368:Aged; D000732:Androstanols / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications* / Q000503:physiopathology; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000627:therapeutic use*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium