title: The sister bonding of duplicated chromosomes.
abstract: Sister chromatid cohesion and separation are two fundamental chromosome dynamics that are essential to equal chromosome segregation during cell proliferation. In this review, I will discuss the major steps that regulate these dynamics during mitosis, with an emphasis on vertebrate cells. The implications of these machineries outside of sister chromatid cohesion and separation are also discussed.
authors.affiliation: Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75252-9148, United States. hui.zou@utsouthwestern.edu
authors.forename: Hui
authors.initials: H
authors.lastname: Zou
mesh_terms: D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002503:Centromere / Q000378:metabolism*; D011508:Chondroitin Sulfate Proteoglycans / Q000235:genetics / Q000378:metabolism; D002842:Chromatids / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism*; D020090:Chromosome Segregation / Q000502:physiology*; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D008938:Mitosis; D064247:Separase; D015398:Signal Transduction; D014714:Vertebrates; D000097722:Cohesins; D000098550:Structural Maintenance of Chromosome Protein 1
chemical_list: D000123:Acetyltransferases; D018797:Cell Cycle Proteins; D011508:Chondroitin Sulfate Proteoglycans; D002868:Chromosomal Proteins, Non-Histone; D010450:Endopeptidases; D064247:Separase; D000097722:Cohesins; D000098550:Structural Maintenance of Chromosome Protein 1; C492318:SMC3 protein, human; C479413:ESCO1 protein, human; C500785:ESCO2 protein, human