title: Haplotype analysis of prostate stem cell antigen and association with prostate cancer risk.
abstract: OBJECTIVE
  Prostate stem cell antigen has become a promising target as a potential biomarker for prostate cancer, but to our knowledge there are no reports of a genetic variation of the PSCA gene associated with prostate cancer risk. We determined the potential association between specific variations of the PSCA gene and prostate cancer in Korean men.
  
  
  METHODS
  In this hospital based, case-control study 194 patients newly diagnosed with histologically confirmed prostate cancer were enrolled. Visitors for cancer screening served as healthy controls. We genotyped 12 PSCA gene single nucleotide polymorphisms in 194 cases and 169 healthy controls.
  
  
  RESULTS
  Men with the rs1045531 AA genotype were at higher risk for prostate cancer than those with the CC genotype. Individuals with the CCCAGGTACGG haplotype were at significantly increased risk for prostate cancer. When considering clinical factors, rs3736001, which is a nonsynonymous cDNA single nucleotide polymorphism (Glu39Lys), showed an association with prostate specific antigen 10 ng/ml or greater and prostate cancer risk.
  
  
  CONCLUSIONS
  Men with the rs1045531 AA genotype of PSCA were at higher risk for prostate cancer. On haplotype analysis CCCAGGTACGG and CGA haplotype carriers showed a significant association with prostate cancer risk. To our knowledge this is the first report of PSCA genetic variation associated with prostate cancer risk.
authors.affiliation: National Cancer Center, Goyang, Republic of Korea.
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Joung
authors.forename: Yeon-Su
authors.initials: YS
authors.lastname: Lee
authors.forename: Sohee
authors.initials: S
authors.lastname: Park
authors.forename: Hyekyoung
authors.initials: H
authors.lastname: Yoon
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Weon Seo
authors.initials: WS
authors.lastname: Park
authors.forename: Ho Kyung
authors.initials: HK
authors.lastname: Seo
authors.forename: Jinsoo
authors.initials: J
authors.lastname: Chung
authors.forename: Sook-young
authors.initials: SY
authors.lastname: Kim
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Hong
authors.forename: Jeong Seon
authors.initials: JS
authors.lastname: Kim
authors.forename: Kang Hyun
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics*; D016022:Case-Control Studies; D058851:GPI-Linked Proteins / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors
chemical_list: D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; D009363:Neoplasm Proteins; C110843:PSCA protein, human