title: Nodulogenesis and goitrogenesis.
abstract: Goitrogenisis is the consequence of a relative iodine deficiency interacting with a genetic predisposition for maladaptation to iodine deficiency. In the long run, the iodine deficiency induces increased H₂O₂ production that leads to an increased mutagenesis, resulting in somatic mutations with a proliferative advantage and thus the induction of thyroid nodules.
authors.affiliation: Department for Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. Ralf.Paschke@medizin.uni-leipzig.de
authors.forename: R
authors.initials: R
authors.lastname: Paschke
mesh_terms: D005260:Female; D020022:Genetic Predisposition to Disease; D006044:Goiter, Nodular / Q000235:genetics*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007455:Iodine / Q000172:deficiency*; D008297:Male; D016296:Mutagenesis; D016606:Thyroid Nodule / Q000235:genetics*
chemical_list: D007455:Iodine; D006861:Hydrogen Peroxide