title: [Cholinesterase blockers in anesthesiology: a replenishment of former arsenal].
abstract: Cholinesterase blockers are widely used in various fields of clinical medicine. In anesthesiology they are used for the means of decurarisation, as well as for performance of central segmental blockades. In recent years, along with the most frequently used neostigmine again an opportunity arose to use the well-known galantamine. A brief overview of the pharmacological properties of galantamine is completed by the study of its efficacy and safety in 30 patients (first group) who underwent general anesthesia with total myoplegia at a range of abdominal surgeries. The comparison group (second group) included 30 patients who were applied neostigmine. The method of clinical functional evaluation, the accelerometry and frontal electromyography confirmed that galantamine although inferior to neostigmine in efficiency, has a higher safety threshold.
authors.forename: A A
authors.initials: AA
authors.lastname: Buniatian
authors.forename: V I
authors.initials: VI
authors.lastname: Stamov
authors.forename: V M
authors.initials: VM
authors.lastname: Mizikov
authors.forename: A V
authors.initials: AV
authors.lastname: Peĭkarova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000776:Anesthesiology / Q000379:methods*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D005702:Galantamine / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects*; D009388:Neostigmine / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019148:Neuromuscular Blockade / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002800:Cholinesterase Inhibitors; D005702:Galantamine; D009388:Neostigmine