title: Positive patch- and photopatch-test reactions to methylene bis-benzotriazolyl tetramethylbutylphenol in patients with both atopic dermatitis and chronic actinic dermatitis.
abstract: Ultraviolet filters are the most common topical photoallergens. Although currently not available on the US market, methylene bis-benzotriazolyl tetramethylbutylphenol (referred to as bisoctrizole on product labels) represents a new class of UV filters that have both organic and inorganic properties and are widely available in different preparations in Europe, South America, and Asia. We report two patients with atopic dermatitis and chronic actinic dermatitis who had positive patch- and photopatch-test reactions, which suggested both an allergic contact and a photoallergic contact dermatitis from bisoctrizole. Neither patient could identify previous or current contact with the chemical; nonetheless, it is possible that either the allergic contact or photoallergic contact dermatitis from bisoctrizole led to their chronic actinic dermatitis.
authors.affiliation: Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.
authors.forename: Mercedes E
authors.initials: ME
authors.lastname: Gonzalez
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Soter
authors.forename: David E
authors.initials: DE
authors.lastname: Cohen
mesh_terms: D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D003876:Dermatitis, Atopic / Q000150:complications; D017454:Dermatitis, Photoallergic / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods; D010636:Phenols / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000150:complications; D013473:Sunscreening Agents / Q000009:adverse effects*; D014227:Triazines / Q000009:adverse effects*
chemical_list: D010636:Phenols; D013473:Sunscreening Agents; D014227:Triazines; C500403:methylene bis-benzotriazolyl tetramethylphenol