title: Significance of smoking status regarding outcomes after radical prostatectomy.
abstract: OBJECTIVE
  We aimed to investigate significance of smoking regarding pathologic and biochemical outcomes following radical prostatectomy (RP).
  
  
  METHODS
  We reviewed data of 1,165 patients who underwent RP without any neoadjuvant or adjuvant therapy at our institution. Patients were categorized into two groups for our analysis: smoking (current smoker at admission for surgery) and nonsmoking (never smoked or former smokers) group. Association of smoking status with adverse pathologic features and biochemical recurrence-free survival were analyzed according to patients' body mass index (BMI) as well as in total patients.
  
  
  RESULTS
  In multivariate analyses, smoking was not found to be significantly associated with various adverse pathologic features and biochemical recurrence-free survival among total patients (all P > 0.05). However, when only the patients with BMI ≥ 25 kg/m(2) were analyzed, smoking at RP was observed to be an independent preoperative predictor of high (≥ 8) pathologic Gleason score (P = 0.025) and biochemical recurrence-free survival (P = 0.016) in multivariate analyses.
  
  
  CONCLUSIONS
  Although smoking was not observed to be significantly associated with worse pathologic and biochemical outcome among overall patients who underwent RP, smoking was found to be a significant preoperative predictor of more aggressive disease and worse biochemical outcome among those with relatively higher BMI.
authors.affiliation: Department of Urology, Seoul National University Bundang Hospital, 300, Gumi-dong, Bundang-gu, Seongnam, Kyunggi-do 463-707, Korea.
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Oh
authors.forename: Sung Kyu
authors.initials: SK
authors.lastname: Hong
authors.forename: Chang Wook
authors.initials: CW
authors.lastname: Jeong
authors.forename: Seok-Soo
authors.initials: SS
authors.lastname: Byun
authors.forename: Sang Eun
authors.initials: SE
authors.lastname: Lee
mesh_terms: D000368:Aged; D015992:Body Mass Index; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000097:blood*; D018365:Neoplasm, Residual; D011379:Prognosis; D016016:Proportional Hazards Models; D011467:Prostate / Q000473:pathology / Q000601:surgery; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects*
chemical_list: D017430:Prostate-Specific Antigen