title: [Hyperferritinemia, ferropenia and metabolic syndrome in a patient with a new mutation of gene TFR2 and another in gene FTL. A family study].
abstract: OBJECTIVE
  Hyperferritinemia is a common finding in clinical practice. This condition can be congenital or acquired, although it is not always associated with iron overload. Genetic hyperferritinemia is associated with iron overload, hereditary hemochromatosis, or cataracts that progress without iron overload (hereditary hyperferritinemia-cataract syndrome). Metabolic syndrome is associated with hyperferritinemia and mild iron overload, with no increase in transferrin saturation. We report a family with hyperferritinemia.
  
  
  METHODS
  We present the study of a family with dual hyperferritinemia (congenital and acquired) and an analysis of the genes involved in iron metabolism.
  
  
  RESULTS
  Patients with hereditary hyperferritinemia-cataract syndrome have the mutation c.-167C>T in the FTL gene; patients with metabolic syndrome present a new mutation in the TFR2 gene (c.1259G>A, p.Arg420His).
  
  
  CONCLUSIONS
  The phenotypic and genotypic diversity of hyperferritinemia makes it a diagnostic challenge for clinicians. Basic research and clinical research should be combined to ensure better patient care.
authors.affiliation: Unidad de Ferropatología y Radicalosis, Departamento de Medicina Interna, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, Madrid, España. adelcastillo.hgugm@salud.madrid.org
authors.forename: Alejandro
authors.initials: A
authors.lastname: Del Castillo-Rueda
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Moreno-Carralero
authors.forename: Nuria
authors.initials: N
authors.lastname: Cuadrado-Grande
authors.forename: Manuel
authors.initials: M
authors.lastname: Méndez
authors.forename: María Josefa
authors.initials: MJ
authors.lastname: Morán-Jiménez
mesh_terms: D000328:Adult; D000465:Algorithms; D001052:Apoferritins / Q000235:genetics*; D002386:Cataract / Q000151:congenital* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006801:Humans; D000090463:Iron Deficiencies; D019189:Iron Metabolism Disorders / Q000151:congenital* / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D009154:Mutation; D010375:Pedigree; D011990:Receptors, Transferrin / Q000235:genetics*
chemical_list: C507433:FTL protein, human; D011990:Receptors, Transferrin; C503640:TFR2 protein, human; D001052:Apoferritins