title: Spontaneous high-frequency action potential.
abstract: Action potential, which is the foundation of physiology and electrophysiology, is most vital in physiological research. This work starts by detecting cardiac electrophysiology (tachyarrhythmias), combined with all spontaneous discharge phenomena in vivo such as wound currents and spontaneous neuropathic pain, elaborates from generation, induction, initiation, to all of the features of spontaneous high-frequency action potential-SSL action potential mechanism, i.e., connecting-end hyperpolarization initiates spontaneous depolarization and action potential in somatic membrane. This work resolves the conundrums of in vivo spontaneous discharge in tachyarrhythmias, wounds, denervation supersensitivity, neurogenic pain (hyperalgesia and allodynia), epileptic discharge and diabetic pain in pathophysiological and clinical researches that have puzzled people for a hundred years.
authors.affiliation: Department of Biochemistry and Molecular Biology, Medical Research Center and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Haiying
authors.initials: H
authors.lastname: Shen
authors.forename: Wonchae
authors.initials: W
authors.lastname: Choe
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology; D002462:Cell Membrane / Q000378:metabolism; D018031:Connexin 43 / Q000378:metabolism; D004594:Electrophysiology; D004827:Epilepsy / Q000503:physiopathology; D006329:Heart Conduction System / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000503:physiopathology; D009437:Neuralgia / Q000503:physiopathology; D011188:Potassium / Q000378:metabolism; D013610:Tachycardia / Q000503:physiopathology
chemical_list: D018031:Connexin 43; D011188:Potassium