title: The emerging role of APC/CCdh1 in development.
abstract: The function of APC/C (anaphase-promoting complex/cyclosome) was initially implicated with the onset of anaphase during mitosis, where its association with Cdc20 targets securin for destruction, thereby allowing the separation of two duplicated daughter genomes. When combined with Cdh1, APC regulates G1/S transition and DNA replication during cell cycle. Beyond cell cycle control, results from recent biochemical and mouse genetic studies have attracted our attention to the unexpected impact of APC/C(Cdh1) in cellular differentiation, genomic integrity and pathogenesis of various diseases. This review will aim to summarize current understanding of APC/C(Cdh1) in regulating crucial events during development.
authors.affiliation: Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States.
authors.forename: Dong
authors.initials: D
authors.lastname: Hu
authors.forename: Xinxian
authors.initials: X
authors.lastname: Qiao
authors.forename: George
authors.initials: G
authors.lastname: Wu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wan
mesh_terms: D000705:Anaphase / Q000502:physiology*; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D016193:G1 Phase / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D042822:Genomic Instability; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D051379:Mice; D055495:Neurogenesis / Q000502:physiology; D009866:Oogenesis / Q000502:physiology; D011485:Protein Binding; D016192:Resting Phase, Cell Cycle / Q000502:physiology*; D043743:Ubiquitin-Protein Ligase Complexes / Q000235:genetics / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; C577488:CDC20 protein, human; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D044767:Ubiquitin-Protein Ligases