title: Pathologic Rupture of the Spleen as the Presenting Symptom of Primary Splenic Non-Hodgkin Lymphoma.
abstract: Pathologic splenic rupture is defined as the spontaneous rupture of a diseased spleen and is quite rare. It is usually associated with oncologic, infectious, and hematologic diseases and more seldom with other rare causes. Pathologic splenic rupture related to hematologic malignancy seems to be rare with only 136 cases reported from 1861 until 1996 and a few cases thereafter. Non-Hodgkin lymphoma and acute myeloid leukemia are most frequently reported followed by chronic myeloid leukemia and lymphoblastic acute leukemia. However, even in cases of non-Hodgkin lymphoma, pathologic splenic rupture as the presenting symptom of the disease is rare as is the presence of primary splenic lymphoma. Conservative treatment is not an option, while operative intervention and emergency splenectomy is the only feasible treatment. We present a very rare case of pathologic rupture of primary splenic lymphoma which was the presenting symptom of the disease.
authors.affiliation: First Surgical Department, General Regional Hospital 'George Papanikolaou', Thessaloniki, Greece. telonakos@hotmail.com.
authors.forename: Orestis
authors.initials: O
authors.lastname: Ioannidis
authors.affiliation: Department of Pathology, General Regional Hospital 'George Papanikolaou', Thessaloniki, Greece.
authors.forename: Styliani
authors.initials: S
authors.lastname: Papaemmanouil
authors.affiliation: Department of Anatomy, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Paraskevas
authors.affiliation: First Surgical Department, General Regional Hospital 'George Papanikolaou', Thessaloniki, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Chatzopoulos
authors.affiliation: First Surgical Department, General Regional Hospital 'George Papanikolaou', Thessaloniki, Greece.
authors.forename: Anastasios
authors.initials: A
authors.lastname: Kotronis
authors.affiliation: First Surgical Department, General Regional Hospital 'George Papanikolaou', Thessaloniki, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papadimitriou
authors.affiliation: First Surgical Department, General Regional Hospital 'George Papanikolaou', Thessaloniki, Greece.
authors.forename: Athina
authors.initials: A
authors.lastname: Konstantara
authors.affiliation: First Surgical Department, General Regional Hospital 'George Papanikolaou', Thessaloniki, Greece.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Makrantonakis
authors.affiliation: First Surgical Department, General Regional Hospital 'George Papanikolaou', Thessaloniki, Greece.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Kakoutis
mesh_terms: D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D011379:Prognosis; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D013161:Splenic Rupture / Q000175:diagnosis* / Q000601:surgery