title: The expression of sialic fibronectin correlates with lymph node metastasis of thyroid malignant neoplasmas.
abstract: BACKGROUND
  Papillary thyroid carcinoma (PTC) is often accompanied by lymph node metastasis (LNM), compared with follicular thyroid carcinoma (FTC). Sialic acid is carried by fibronectin (sFN) as the antigen of monoclonal antibody (MoAb) JT-95 detected in 90% of PTC, and a few cases of FTC.
  
  
  METHODS
  JT-95 staining was performed in 9 PTC and 20 follicular type tumors to investigate the relationship between the expression of sFN and the frequency of LNM.
  
  
  RESULTS
  There were 11 cases with LNM from 23 malignant tumors, and no cases of LNM from 6 benign follicular type tumors. The staining scores by JT-95 of the 11 tumors with LNM were 5+ in 4 cases, and 6+ in 7 cases. On the other hand, the scores of 12 malignant tumors without LNM were <4+ in all cases.
  
  
  CONCLUSIONS
  An increase of sFN expression in thyroid malignancies is correlated with LNM.
authors.affiliation: Department of Surgery, Jikei University School of Medicine, Tokyo 105-8461, Japan. takeyama@jikei.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeyama
authors.forename: Shigeya
authors.initials: S
authors.lastname: Kyoda
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Okamoto
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Manome
authors.forename: Michiko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Satoki
authors.initials: S
authors.lastname: Kinoshita
authors.forename: Ken
authors.initials: K
authors.lastname: Uchida
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Morikawa
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000276:immunology / Q000378:metabolism / Q000556:secondary; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000276:immunology / Q000378:metabolism / Q000556:secondary; D005260:Female; D005353:Fibronectins / Q000276:immunology / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000276:immunology / Q000378:metabolism*; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D005353:Fibronectins; D019158:N-Acetylneuraminic Acid