title: Neuroprotective labdane diterpenes from Fritillaria ebeiensis.
abstract: By bioactivity-guided isolation, two labdane diterpenes (1 and 2) have been isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated as 6α,7β-dihydroxy-labda-8(17),12(E),14-triene (1) and 6-oxo-2α-hydroxy-labda-7,12(E), 14-triene (2), on the basis of spectroscopic data analysis (IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR). Both of the isolates showed neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Cuizhou
authors.initials: C
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Guo
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Song
authors.forename: Zhanping
authors.initials: Z
authors.lastname: Sun
authors.forename: Liping
authors.initials: L
authors.lastname: Gui
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Ma
mesh_terms: D016923:Cell Death / Q000187:drug effects*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031410:Fritillaria / Q000737:chemistry*; D006801:Humans; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots
chemical_list: C568438:6-oxo-2alpha-hydroxy-labda-7,12(E),14-triene; C568437:6alpha,7beta-dihydroxy-labda-8(17),12(E),14-triene; D004224:Diterpenes; D018696:Neuroprotective Agents; D010936:Plant Extracts