title: HLA-G as predisposing for metastasis.
abstract: HLA-G, a very conserved non-classical class I human leukocyte antigen, is highly expressed in cancer pathologies. Recent evidences about HLA-G implication in immune tolerance announce the probable association between HLA-G and metastasis. We highlighted here possible mechanisms for link between HLA-G regulation and cascade metastasis including initiation, progression, and virulence steps. A thorough understanding of HLA-G implications in metastasis through future clinical studies, may probably lead to the improvement of cancer therapies and the limitation of relapses and metastasis.
authors.affiliation: Laboratory of Biochemistry, Research Unit 02/UR/09-01, Higher Institute of Biotechnology of Monastir, Tunisia. ines.zidi@techemail.com
authors.forename: Ines
authors.initials: I
authors.lastname: Zidi
authors.forename: Nidhal
authors.initials: N
authors.lastname: Ben Amor
mesh_terms: D006680:HLA Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D009362:Neoplasm Metastasis / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I