title: [Analysis of morphological manifestations of the inflammatory reaction in wistar rat spinal cord in experimental model].
abstract: Morphological changes in the spinal cord of rats with different intensity of pathological symptoms were studied at the peak of the experimental encephalomyelitis development. Light-microscopical and immunohistochemical methods were used. Distribution of proliferating cell nuclear antigen (PCNA), astrocyte marker - glial fibrillar acidic protein (GFAP), and microglia and macrophage marker Iba-1, was studied. Heterogeneity in morphological manifestations of the experimental allergic encephalomyelitis was shown. Four typical patterns of morphological manifestations of the disease were demonstrated depending on the preferential involvement of pia mater, vessels, spinal cell nuclei or conductive tracts in the pathological process.
authors.forename: E G
authors.initials: EG
authors.lastname: Gilerovich
authors.forename: E A
authors.initials: EA
authors.lastname: Fedorova
authors.forename: I N
authors.initials: IN
authors.lastname: Abdurasulova
authors.forename: M N
authors.initials: MN
authors.lastname: Karpenko
authors.forename: A V
authors.initials: AV
authors.lastname: Sokolov
authors.forename: E T
authors.initials: ET
authors.lastname: Zakharova
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Zhitnukhin
authors.forename: D É
authors.initials: DÉ
authors.lastname: Korzhevskiĭ
authors.forename: V B
authors.initials: VB
authors.lastname: Vasil'ev
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000096:biosynthesis / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D005260:Female; D008840:Microfilament Proteins; D009187:Myelitis / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000276:immunology; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
chemical_list: C100745:Aif1 protein, rat; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; D018809:Proliferating Cell Nuclear Antigen