title: Cyclic estrous-like behavior in a spayed cat associated with excessive sex-hormone production by an adrenocortical carcinoma.
abstract: A 15-year-old, spayed female domestic shorthair cat was evaluated for 1-year duration of cyclic intermittent estrous behavior. Diagnostic testing performed before referral, including baseline progesterone concentration, human chorionic gonadotropin (hCG) hormone stimulation test and surgical exploratory laparotomy, had remained inconclusive for a remnant ovary. Evaluation of sex hormones before and after adrenocorticotropic hormone (ACTH) administration revealed increased basal concentrations of androstenedione, estradiol, progesterone, and 17α-hydroxyprogesterone and normal ACTH-stimulated hormone concentrations. Enlargement of the right adrenal gland was identified by abdominal ultrasound. The cat underwent an adrenalectomy and histopathology of the excised adrenal gland was consistent with an adrenocortical carcinoma. Clinical signs resolved immediately following surgery, and most hormone concentrations declined to within or below the reference interval (RI) by 2 months after surgery.
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West-Lafayette, IN 47907, USA.
authors.forename: Erika N
authors.initials: EN
authors.lastname: Meler
authors.forename: J Catharine
authors.initials: JC
authors.lastname: Scott-Moncrieff
authors.forename: Augustine T
authors.initials: AT
authors.lastname: Peter
authors.forename: Sara
authors.initials: S
authors.lastname: Bennett
authors.forename: Jose
authors.initials: J
authors.lastname: Ramos-Vara
authors.forename: S Kathleen
authors.initials: SK
authors.lastname: Salisbury
authors.forename: James F
authors.initials: JF
authors.lastname: Naughton
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000601:surgery / Q000662:veterinary*; D018268:Adrenocortical Carcinoma / Q000097:blood / Q000601:surgery / Q000662:veterinary*; D000735:Androstenedione / Q000097:blood; D000818:Animals; D002371:Cat Diseases / Q000097:blood* / Q000601:surgery; D002415:Cats; D004958:Estradiol / Q000097:blood; D030762:Estrous Cycle / Q000097:blood*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D011374:Progesterone / Q000097:blood; D016896:Treatment Outcome
chemical_list: D012739:Gonadal Steroid Hormones; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D019326:17-alpha-Hydroxyprogesterone