title: Clinical features of punctate inner choroidopathy in Chinese patients.
abstract: OBJECTIVE
  To characterize the clinical features of punctate inner choroidopathy (PIC) in Chinese patients.
  
  
  METHODS
  A retrospective chart review of all patients admitted with PIC from June 1999 to October 2009.
  
  
  RESULTS
  Of the 75 patients (112 eyes) diagnosed with PIC, 72% were women, 80% were myopic, and 49% exhibited bilateral involvement. The mean age at presentation was 32 years. Blurred central vision (64%) and scotoma (40%) were the most common symptoms. Multifocal PIC lesions were mostly restricted to the posterior pole (95%). The acute lesions were yellow and demonstrated hyperfluorescence (61%) or mild hyperfluorescence (36%) on fluorescein angiography, mostly (75%) <200 μm in diameter and <10 in number. Indocyanine angiography showed subclinical hypofluorescent spots in 32% of the affected eyes. Choroidal neovascularization developed in 63% of affected eyes. Papilledema (3%) and segmental retinal phlebitis (2%) were rare. Intact follow-up data of 27 patients (43 eyes) were available. Acute lesions turned into punched-out atrophic lesions within 3 months. New visible lesions developed in 5 eyes within 1 year after symptom onset. New choroidal neovascularization developed in five eyes. The mean best-corrected visual acuity significantly improved at last follow-up (P = 0.039).
  
  
  CONCLUSIONS
  Punctate inner choroidopathy in Chinese is not rare and primarily affects young myopic women. It features multifocal, small, yellow lesions that develop within a short period, principally in the posterior pole, with subsequent atrophy. Complicated choroidal neovascularization is frequent. General visual prognosis is moderately good.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
authors.forename: Xiongze
authors.initials: X
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Wen
authors.forename: Chengguo
authors.initials: C
authors.lastname: Zuo
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Shizhou
authors.initials: S
authors.lastname: Huang
authors.forename: Guangwei
authors.initials: G
authors.lastname: Luo
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology; D002681:China / Q000453:epidemiology; D002829:Choroid / Q000473:pathology; D015862:Choroid Diseases / Q000175:diagnosis* / Q000208:ethnology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications; D012189:Retrospective Studies; D014786:Vision Disorders / Q000175:diagnosis / Q000208:ethnology; D014792:Visual Acuity; D055815:Young Adult