title: Mechanisms of resolution of inflammation: a focus on cardiovascular disease.
abstract: The inflammatory response is an integral part of the innate immune mechanism that is triggered in response to a real or perceived threat to tissue homeostasis, with a primary aim of neutralizing infectious agents and initiating repair to damaged tissue. By design, inflammation is a finite process that resolves as soon as the threat of infection abates and sufficient repair to the tissue is complete. Resolution of inflammation involves apoptosis and subsequent clearance of activated inflammatory cells--a tightly regulated event. Chronic inflammation is a characteristic feature in virtually all inflammatory diseases, including atherosclerosis, and it is becoming increasingly clear that derangement of the processes usually involved in resolution of inflammation is an underlying feature of chronic inflammatory conditions. This review will draw on evidence from a range of diseases in which dysregulated inflammation is important, with particular emphasis on cardiovascular disease.
authors.affiliation: Lipidomic Research Facility, UHI Department of Diabetes and Cardiovascular Science, Highland Diabetes Institute, Centre for Health Science, Old Perth Road, Inverness IV2 3JH, Scotland. Ben.Maskrey@uhi.ac.uk
authors.forename: Benjamin H
authors.initials: BH
authors.lastname: Maskrey
authors.forename: Ian L
authors.initials: IL
authors.lastname: Megson
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Whitfield
authors.forename: Adriano G
authors.initials: AG
authors.lastname: Rossi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D017209:Apoptosis; D002318:Cardiovascular Diseases / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D009569:Nitric Oxide / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators; D009569:Nitric Oxide; D018844:Cyclin-Dependent Kinases