title: Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues.
abstract: Selective disposition of nanocarriers into target tissue is an essential issue in drug delivery. Critical size of nanocarriers (∼150 nm) discriminating the permeability into normal and tumor tissues was determined by the use of size-tunable, polyion complex hollow vesicles (PICsome) as a ruler.
authors.affiliation: Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Anraku
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kishimura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Oba
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kataoka
mesh_terms: D000818:Animals; D002232:Carbocyanines / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D002232:Carbocyanines; D004337:Drug Carriers; C085321:cyanine dye 5; D011092:Polyethylene Glycols