title: A diet rich in monounsaturated fatty acids improves the lipid profile of mice previously on a diet rich in saturated fatty acids.
abstract: This study investigated whether switching from a diet rich in saturated fatty acids (SAFAs) to a diet rich in monounsaturated fatty acids (MUFAs) or to one with equal amounts of MUFAs-SAFAs favorably affects the lipid profile of hypercholesterolemic mice. C57BL/6 mice (n = 82) were allocated into 4 groups. The first group (control, n = 10) was fed standard chow. The 3 remaining groups (n = 24 mice/group) were fed a SAFA-rich diet for 8 weeks and were then allocated for 16 weeks to either a MUFA-rich diet, an equal in MUFAs-SAFAs-rich diet, or continued the previous SAFA-rich diet. After 8 weeks, mice consuming SAFA-rich diet had increased weight, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) levels (P < .05 vs baseline). At week 24, MUFA-rich and MUFA-SAFA rich diets decreased TC and low-density lipoprotein cholesterol (LDL-C) levels (P < .05) compared with week 8. In conclusion, switching to MUFA-rich diets or substituting half of the SAFAs with MUFAs can reverse diet-induced-hypercholesterolemia.
authors.affiliation: First Department of Propaedeutic Medicine, Laiko General Hospital, Athens University Medical School, Athens, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Arapostathi
authors.forename: Irene P
authors.initials: IP
authors.lastname: Tzanetakou
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Kokkinos
authors.forename: Nicholas K
authors.initials: NK
authors.lastname: Tentolouris
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Vlachos
authors.forename: Ismini A
authors.initials: IA
authors.lastname: Donta
authors.forename: Kalliopi N
authors.initials: KN
authors.lastname: Perrea
authors.forename: Despina N
authors.initials: DN
authors.lastname: Perrea
authors.forename: Nicholaos L
authors.initials: NL
authors.lastname: Katsilambros
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016896:Treatment Outcome
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D008055:Lipids