title: The cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations.
abstract: OBJECTIVE
  Studies of the association between the cyclin D1 (CCND1) G870A genetic polymorphism and risk of colorectal cancer (CRC) have generated conflicting results. In order to derive a more precise estimation, a meta-analysis was here performed.
  
  
  METHODS
  An extensive search of relevant studies was carried out as a meta-analysis of twenty studies with 5,975 cases and 8,333 controls.
  
  
  RESULTS
  Overall, a significantly elevated colorectal cancer risk was associated with variant allele 870A when all studies were pooled (AA vs. GG: OR = 1.23, 95%CI = 1.04-1.44; GA vs. GG: OR = 1.13, 95% CI = 1.01-1.26; dominant model: OR = 1.16, 95%CI = 1.03-1.31). In the subgroup analysis by ethnicity, significantly increased risks were detected among Caucasians (AA vs. GG: OR = 1.27, 95%CI = 1.04-1.44; and dominant model: OR = 1.17, 95%CI = 1.02-1.34). With stratification into sporadic CRC and hereditary nonpolyposis colorectal cancer (HNPCC), the former demonstrated increased cancer susceptibility (AA vs. GG: OR = 1.24, 95%CI = 1.04-1.48; dominant model: OR = 1.17, 95%CI = 1.04-1.33). However, no significant associations were found in either Asians or HNPCC patients for any genetic model.
  
  
  CONCLUSIONS
  The results suggest that the cyclin D1 870A allele is a low-penetrant risk factor for development of sporadic colorectal cancer, especially among Caucasians.
authors.affiliation: Department of Medical Oncology, Nanjing Medical University, China.
authors.forename: Lou Qian
authors.initials: LQ
authors.lastname: Zhang
authors.forename: Xin En
authors.initials: XE
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Jun Qing
authors.initials: JQ
authors.lastname: Shang
authors.forename: Jianling
authors.initials: J
authors.lastname: Bai
authors.forename: Fu Yin
authors.initials: FY
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Guan
authors.forename: Jian Nong
authors.initials: JN
authors.lastname: Zhou
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000208:ethnology / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D019938:Cyclin D1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1