title: Combined effects of Gm or Km immunoglobulin allotypes and age on antibody responses to Plasmodium falciparum VarO rosetting variant in Benin.
abstract: Clinical protection of Beninese children against Plasmodium falciparum malaria was shown to be influenced by immunoglobulin (IG) Gm and Km allotypes, and related to seroreactivity with the rosette-forming VarO-antigenic variant. IgG to the VarO-infected erythrocyte surface, IgG1 and IgG3 to PfEMP1-NTS-DBL1α(1)-VarO were higher in the under 4-year-old children carrying the Gm 5,6,13,14;1,17 phenotype. In contrast, surface-reactive IgG, total IgG, IgG1 and IgG3 to NTS-DBL1α(1)- and DBL2βC2-VarO domains were lower in the above 4-year-old children harbouring the Km1 allotype. These data outline an age-related association of antibodies against malaria antigens and IG allotype distribution.
authors.affiliation: Institut de Recherche pour le Développement, UMR 216 Mère et enfant face aux infections tropicales, 4 avenue de l'Observatoire, 75006 Paris, France. florence.migot-nabias@ird.fr
authors.forename: Florence
authors.initials: F
authors.lastname: Migot-Nabias
authors.forename: Adjimon G
authors.initials: AG
authors.lastname: Lokossou
authors.forename: Inès
authors.initials: I
authors.lastname: Vigan-Womas
authors.forename: Evelyne
authors.initials: E
authors.lastname: Guitard
authors.forename: Micheline
authors.initials: M
authors.lastname: Guillotte
authors.forename: Julien M
authors.initials: JM
authors.lastname: Noukpo
authors.forename: Odile
authors.initials: O
authors.lastname: Mercereau-Puijalon
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Dugoujon
authors.forename: André
authors.initials: A
authors.lastname: Garcia
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000704:Analysis of Variance; D000913:Antibodies, Protozoan / Q000276:immunology*; D001541:Benin / Q000453:epidemiology; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000145:classification / Q000276:immunology*; D007131:Immunoglobulin Km Allotypes / Q000145:classification / Q000276:immunology*; D007223:Infant; D016014:Linear Models; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D007129:Immunoglobulin Gm Allotypes; D007131:Immunoglobulin Km Allotypes; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum