title: [Blood coagulation parameters in children with acute promyelocytic leukemia, their changes during all-trans retinoic acid treatment, and causes of hemorrhagic and thrombotic events].
abstract: The specific feature of acute promyelocytic leukemia (APL) is blood coagulation impairments that appear as thrombohemorrhagic disorders with a possible fatal outcome. The pathogenesis of bleeding in APL is due to the properties of leukemic promyelocytes; however, little is known about the causes of venous thrombosis in APL. This circumstance determined the objective of the investigation, which was to study the functional state of blood coagulation over time during treatment for APL and to reveal the causes of thromboses in children with this condition. There was a relationship of the Leiden mutation in patients with APL to the development of thrombosis (p = 0.009). Vein catheterization and puncture are other provoking factors of thrombosis.
authors.forename: N V
authors.initials: NV
authors.lastname: Lipaĭ
mesh_terms: D000293:Adolescent; D001777:Blood Coagulation / Q000187:drug effects*; D002648:Child; D005165:Factor V / Q000235:genetics; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000235:genetics / Q000517:prevention & control*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D009154:Mutation; D020246:Venous Thrombosis / Q000097:blood / Q000235:genetics / Q000517:prevention & control*
chemical_list: C095381:factor V Leiden; D005165:Factor V