title: Organocatalytic enantioselective Michael addition of malononitrile to nitroolefins catalyzed by bifunctional thiourea.
abstract: A novel enantioselective Michael addition of malononitrile to trans-β-nitroolefins in the presence of bifunctional amine thiourea organocatalyst is developed. The Michael reaction catalyzed by amine thioureas containing both central and axial chiral elements proceeded smoothly and provided the desired adducts with high yields (up to 96% yield) and moderate enantioselectivities (up to 83% enantiomeric excess).
authors.affiliation: College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang, Henan, People's Republic of China. ghm@henannu.edu.cn
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Li
authors.forename: Gui-Rong
authors.initials: GR
authors.lastname: Qu
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: Yuan