title: CD4+ memory T cell survival.
abstract: Memory CD4+ T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naïve precursors. How memory CD4+ T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this process. Here we review the factors that allow some effector CD4+ T cells to survive the contraction phase of the primary response and become memory cells, and consider whether parallels can be drawn between T and B cells.
authors.affiliation: Department of Microbiology and the Center for Immunology, University of Minnesota, 2101 Sixth St. SE, Minneapolis, MN 55455, United States.
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Taylor
authors.forename: Marc K
authors.initials: MK
authors.lastname: Jenkins
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D002470:Cell Survival; D006801:Humans; D007156:Immunologic Memory