title: Epidemiology of pertussis in a country with high vaccination coverage.
abstract: BACKGROUND
  Pertussis has been a preventable disease in Catalonia since 1965, but the annual number of cases remains high. The aim of this study was to analyze the epidemiology of pertussis in Catalonia and its implications for control purposes.
  
  
  METHODS
  An epidemiological study was carried out in Catalonia between 2004 and 2008. Pertussis cases reported to the Department of Health were collected and disease reports were filled out with the case information. Incidence rates, rate ratios (RR) and their 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  963 cases were reported: 555 (57.6%) were confirmed and 408 (42.4%) were suspected cases. The reported incidence rate was 2.01 × 10(-5) person years in 2004 and 4.34 in 2008. The biggest increase in cases between 2004 and 2008 was observed in the ≥35 years age group (RR: 6.98; 95%CI: 2.11-36.36). 303 (31.5%) patients were hospitalized, of whom 93.7% were aged <1 year. Clinical differences were observed in paroxysmal cough (83.8% in suspected and 76.4% in confirmed cases, p=0.005), posttussive vomiting (47.1% and 36.1%, respectively, p=0.001), apnoea (13.7% and 21.3%, respectively, p=0.003) and fever (20.1% and 12.4%, respectively, p=0.001).
  
  
  CONCLUSIONS
  Pertussis incidence rates increased during the study period, with the greatest increase occurring in the ≥35 years age group. A booster dose of vaccine in young people could reduce the circulation of B. pertussis in adolescents and adults and indirectly reduce the incidence in children.
authors.affiliation: CIBER de Epidemiología y Salud Pública (CIBERESP), Spain. inma.crespo@hotmail.com
authors.forename: Inma
authors.initials: I
authors.lastname: Crespo
authors.forename: Neus
authors.initials: N
authors.lastname: Cardeñosa
authors.forename: Pere
authors.initials: P
authors.lastname: Godoy
authors.forename: Gloria
authors.initials: G
authors.lastname: Carmona
authors.forename: M Rosa
authors.initials: MR
authors.lastname: Sala
authors.forename: Irene
authors.initials: I
authors.lastname: Barrabeig
authors.forename: Josep
authors.initials: J
authors.lastname: Alvarez
authors.forename: Sofia
authors.initials: S
authors.lastname: Minguel
authors.forename: Neus
authors.initials: N
authors.lastname: Camps
authors.forename: Joan
authors.initials: J
authors.lastname: Caylà
authors.forename: Joan
authors.initials: J
authors.lastname: Batalla
authors.forename: Gemma
authors.initials: G
authors.lastname: Codina
authors.forename: Angela
authors.initials: A
authors.lastname: Domínguez
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage*; D013030:Spain / Q000453:epidemiology; D014611:Vaccination / Q000706:statistics & numerical data*; D014917:Whooping Cough / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D010567:Pertussis Vaccine