title: Transport of single cells using an actin bundle-myosin bionanomotor transport system.
abstract: The potential of using actin bundles for the transport of liposomes and single cells across myosin-coated surfaces is investigated. Compared to that observed with filamentous actin, the liposome transport using actin bundles was more linear in nature and able to occur over longer distances. Bundles, but not filamentous actin, were capable of moving single cells. Cargo unloading from bundles was achieved by incubation with Triton X-100. These data suggest that actin bundling may improve the ability of the myosin motor system for nanotransport applications.
authors.affiliation: Department of Biological Sciences, Marshall University, Huntington, WV, USA.
authors.forename: Hideyo
authors.initials: H
authors.lastname: Takatsuki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Rice
authors.forename: Madhukar B
authors.initials: MB
authors.lastname: Kolli
authors.forename: Siva K
authors.initials: SK
authors.lastname: Nalabotu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kohama
authors.forename: Parviz
authors.initials: P
authors.lastname: Famouri
authors.forename: Eric R
authors.initials: ER
authors.lastname: Blough
mesh_terms: D000199:Actins / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D001692:Biological Transport; D019921:Biotinylation; D002645:Chickens; D004926:Escherichia coli / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D008081:Liposomes / Q000648:ultrastructure; D008856:Microscopy, Fluorescence; D024462:Myosin Type II / Q000378:metabolism*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D011817:Rabbits
chemical_list: D000199:Actins; D008081:Liposomes; D024462:Myosin Type II