title: An adamantane-based building block for DNA networks.
abstract: DNA governs the storage and transfer of genetic information through generations in all living systems with the exception of some viruses. Its physicochemical nature and the Watson-Crick base pairing properties allow molecular constructions at nanometer length, thereby enabling the design of desired structural motifs, which can self-assemble to form large supramolecular arrays and scaffolds. The tailor-made DNAs have been an interesting material for such designed nanoscale constructions. However, the synthesis of specific structures with a desired molecular function is still in its infancy and therefore has to be further explored. To add a new dimension to this approach, we have synthesized a rigid three-way branched adamantane motif, which is capable of forming highly stable DNA networks. The moiety generated could serve as a useful building block for DNA-based nanoconstructions.
authors.affiliation: Department of Chemistry and Konstanz Research School of Chemical Biology, University of Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.
authors.forename: Richa
authors.initials: R
authors.lastname: Pathak
authors.forename: Andreas
authors.initials: A
authors.lastname: Marx
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry
chemical_list: D009841:Oligonucleotides; D004247:DNA; D000218:Adamantane