title: Deletion of the late cornified envelope genes LCE3C and LCE3B is associated with psoriasis in a Chinese population.
abstract: A common deletion comprising LCE3B and LCE3C, members of the late cornified envelope (LCE) gene cluster, has been shown to be significantly associated with psoriasis in several Caucasian populations. The expression of LCE can be induced by skin barrier disruption, leading to psoriatic lesions. To identify whether deletion of genes in the LCE region is a genetic risk factor in the pathogenesis of psoriasis, we genotyped the LCE3C and LCE3B deletion and single-nucleotide polymorphism rs4112788, which is in strong linkage disequilibrium with the LCE gene cluster, via direct sequencing in 468 psoriasis patients and 768 controls in a Chinese population. We found that deletion of the two LCE genes was associated with psoriasis (odds ratio=1.917; 95% confidence interval=1.291-2.847, P=0.001), a conclusion that was similar to that of another independent Chinese cohort study. The deletion was not significantly associated with the age of disease onset, and there was no significant epistatic interaction between deletion and PSORS1 risk allele on 6p21.3. Our study confirms an association between the deletion of LCE3C and LCE3B and psoriasis in a Chinese population.
authors.affiliation: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Miaozhu
authors.initials: M
authors.lastname: Li
authors.forename: Yumei
authors.initials: Y
authors.lastname: Wu
authors.forename: Guoliang
authors.initials: G
authors.lastname: Chen
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Yang
authors.forename: Daizhan
authors.initials: D
authors.lastname: Zhou
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zhang
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.forename: Yinwei
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Lu
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data*; D002648:Child; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D055233:Cornified Envelope Proline-Rich Proteins / Q000235:genetics*; D004843:Epistasis, Genetic / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000208:ethnology* / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D055233:Cornified Envelope Proline-Rich Proteins; C549748:LCE3B protein, human; C524768:LCE3C protein, human