title: A novel VIM-type metallo-beta-lactamase (VIM-14) in a Pseudomonas aeruginosa clinical isolate from a neonatal intensive care unit.
abstract: A Pseudomonas aeruginosa highly resistant to carbapenems was isolated in a neonatal intensive care unit in Palermo, Italy. The strain was found to carry a novel VIM-type enzyme, classified as VIM-14. The novel enzyme differs from VIM-4 in a G31S mutation. VIM-14 was harboured in a class 1 integron with a new organization. The integron carried the genes aac7, blaVIM-14, blaOXA-20 and aac4 in that order.
authors.affiliation: Dipartimento di Patologia e Diagnostica, Università di Verona, Verona, Italy. annarita.mazzariol@univr.it
authors.forename: A
authors.initials: A
authors.lastname: Mazzariol
authors.forename: C
authors.initials: C
authors.lastname: Mammina
authors.forename: R
authors.initials: R
authors.lastname: Koncan
authors.forename: V
authors.initials: V
authors.lastname: Di Gaetano
authors.forename: P
authors.initials: P
authors.lastname: Di Carlo
authors.forename: D
authors.initials: D
authors.lastname: Cipolla
authors.forename: G
authors.initials: G
authors.lastname: Corsello
authors.forename: G
authors.initials: G
authors.lastname: Cornaglia
mesh_terms: D001483:Base Sequence; D015780:Carbapenems / Q000494:pharmacology; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D032023:Integrons / Q000187:drug effects; D007363:Intensive Care Units, Neonatal; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D015780:Carbapenems; D004269:DNA, Bacterial; D001618:beta-Lactamases