title: Regenerative chemical biology: current challenges and future potential.
abstract: The enthusiasm surrounding the clinical potential of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) is tempered by the fact that key issues regarding their safety, efficacy, and long-term benefits have thus far been suboptimal. Small molecules can potentially relieve these problems at major junctions of stem cell biology and regenerative therapy. In this review we will introduce recent advances in these important areas and the first generation of small molecules used in the regenerative context. Current chemical biology studies will provide the archetype for future interdisciplinary collaborations and improve clinical benefits of cell-based therapies.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 383 PRB, Nashville, TN 37232, USA.
authors.forename: Ada
authors.initials: A
authors.lastname: Ao
authors.forename: Jijun
authors.initials: J
authors.lastname: Hao
authors.forename: Charles C
authors.initials: CC
authors.lastname: Hong
mesh_terms: D000818:Animals; D001695:Biology / Q000379:methods*; D002454:Cell Differentiation; D006801:Humans; D044968:Regenerative Medicine / Q000379:methods*; D054852:Small Molecule Libraries / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D054852:Small Molecule Libraries