title: Hemodynamic changes quantified in abdominal aortic aneurysms with increasing exercise intensity using mr exercise imaging and image-based computational fluid dynamics.
abstract: Abdominal aortic aneurysm (AAA) is a vascular disease resulting in a permanent, localized enlargement of the abdominal aorta. We previously hypothesized that the progression of AAA may be slowed by altering the hemodynamics in the abdominal aorta through exercise [Dalman, R. L., M. M. Tedesco, J. Myers, and C. A. Taylor. Ann. N.Y. Acad. Sci. 1085:92-109, 2006]. To quantify the effect of exercise intensity on hemodynamic conditions in 10 AAA subjects at rest and during mild and moderate intensities of lower-limb exercise (defined as 33 ± 10% and 63 ± 18% increase above resting heart rate, respectively), we used magnetic resonance imaging and computational fluid dynamics techniques. Subject-specific models were constructed from magnetic resonance angiography data and physiologic boundary conditions were derived from measurements made during dynamic exercise. We measured the abdominal aortic blood flow at rest and during exercise, and quantified mean wall shear stress (MWSS), oscillatory shear index (OSI), and particle residence time (PRT). We observed that an increase in the level of activity correlated with an increase of MWSS and a decrease of OSI at three locations in the abdominal aorta, and these changes were most significant below the renal arteries. As the level of activity increased, PRT in the aneurysm was significantly decreased: 50% of particles were cleared out of AAAs within 1.36 ± 0.43, 0.34 ± 0.10, and 0.22 ± 0.06 s at rest, mild exercise, and moderate exercise levels, respectively. Most of the reduction of PRT occurred from rest to the mild exercise level, suggesting that mild exercise may be sufficient to reduce flow stasis in AAAs.
authors.affiliation: Department of Mechanical Engineering, Stanford University, Stanford, CA, USA.
authors.forename: Ga-Young
authors.initials: GY
authors.lastname: Suh
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Les
authors.forename: Adam S
authors.initials: AS
authors.lastname: Tenforde
authors.forename: Shawn C
authors.initials: SC
authors.lastname: Shadden
authors.forename: Ryan L
authors.initials: RL
authors.lastname: Spilker
authors.forename: Janice J
authors.initials: JJ
authors.lastname: Yeung
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Cheng
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Herfkens
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Dalman
authors.forename: Charles A
authors.initials: CA
authors.lastname: Taylor
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003198:Computer Simulation; D005260:Female; D006439:Hemodynamics; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D005082:Physical Exertion; D011859:Radiography