title: [Effective treatment by both anti-androgen therapy and chemotherapy for a patient with advanced salivary duct carcinoma].
abstract: Salivary ductcarcinoma (SDC)is a high-grade malignant tumor arising predominantly in the parotid gland. Androgen receptor(AR)expression was mainly restricted to SDC in salivary cancer. We report successful treatment of a patient with advanced SDC using an endocrine chemotherapy. A 76-year-old man was hospitalized with lumbalgia and swelling of left submandibular region. Radiological examination indicated a tumor in left submandibular gland and metastatic tumors in lumbar vertebra, accompanied by swollen lymph nodes of the neck, mediastinum. Needle biopsies of both vertebral tumor and cervical lymph node revealed SDC. Positive nuclear staining was observed against AR in tumor cells of our patient by immunohistochemical analysis. He obtained a partial response after 1 course of treatment with both anti-androgen therapy and palliative chemotherapy using paclitaxel. In contrast to previous reports of poor response to chemotherapy alone and short-term survival of patients with SDC, our patient has demonstrated that chemotherapy combined with anti-androgen therapy may be an effective modality as a therapeutic regimen for SDC.
authors.affiliation: Dept. of Gastroenterology, Shinnittetsu Muroran General Hospital, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuroda
authors.forename: Tamaki
authors.initials: T
authors.lastname: Sakurai
authors.forename: Michiko
authors.initials: M
authors.lastname: Yamada
authors.forename: Naoki
authors.initials: N
authors.lastname: Uemura
authors.forename: Michihiro
authors.initials: M
authors.lastname: Ono
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Abe
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Fujii
authors.forename: Masahiro
authors.initials: M
authors.lastname: Maeda
authors.forename: Kyuhei
authors.initials: K
authors.lastname: Kohda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Obata
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Ando
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iyama
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D044584:Carcinoma, Ductal / Q000188:drug therapy* / Q000473:pathology; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use*; D012468:Salivary Gland Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000726:Androgen Antagonists; D000972:Antineoplastic Agents, Phytogenic; D007987:Gonadotropin-Releasing Hormone; D017239:Paclitaxel