title: Two pediatric osteosarcoma cases with delayed methotrexate excretion: its clinical course and management.
abstract: High-dose methotrexate (MTX) chemotherapy extends the duration of hospitalization and introduces the risks of serious complications related to delayed MTX excretion. The treatment of delayed MTX excretion is largely dependent on invasive measures such as hemodialysis because the clinical data regarding the efficacy or safety of carboxypetidase G(2) is limited. We report here on the cases of two pediatric osteosarcoma patients with delayed MTX excretion and who were successfully managed using supportive measures. Potential life-threatening complications were prevented by administering high doses of leucovorin.
authors.affiliation: Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea.
authors.forename: Kang Min
authors.initials: KM
authors.lastname: Lee
authors.forename: Hee Woo
authors.initials: HW
authors.lastname: Lee
authors.forename: Seung Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Hyeon Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Kim
authors.forename: Joongbum
authors.initials: J
authors.lastname: Cho
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Kim
authors.forename: Jung Sub
authors.initials: JS
authors.lastname: Lim
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Lee
authors.forename: Jun Ah
authors.initials: JA
authors.lastname: Lee