title: Host mouse strain is not selective for a laboratory adapted strain of Schistosoma mansoni.
abstract: We genotyped pooled adult worms of Schistosoma mansoni from infected CF1, C57BL/6, BALB/c, and BALB/c interferon gamma knockout mice in order to establish if mouse strain differences selected for parasite genotypes. We also compared differentiation in eggs collected from liver and intestines to determine if there was differential distribution of parasite strains in the vertebrate host that might account for any genotype selection. We found that mouse strains with differing immune responses did not differ in resistance to infection and did not select for parasite genotypes. Schistosoma mansoni egg allele frequencies were also equally distributed in tissues and the difference between adult and egg allele frequencies was negligible.
authors.affiliation: Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA. walter.blank@case.edu
authors.forename: Walter A
authors.initials: WA
authors.lastname: Blank
authors.forename: Shi Fan
authors.initials: SF
authors.lastname: Liu
authors.forename: Jayendra
authors.initials: J
authors.lastname: Prasad
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Blanton
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D001700:Biomphalaria; D018509:DNA, Helminth; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D007074:Immunoglobulin G / Q000097:blood; D007371:Interferon-gamma / Q000235:genetics; D007422:Intestines / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012550:Schistosoma mansoni / Q000145:classification* / Q000235:genetics / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000469:parasitology*; D012744:Sex Ratio
chemical_list: D000909:Antibodies, Helminth; D018509:DNA, Helminth; D007074:Immunoglobulin G; D007371:Interferon-gamma