title: [ART with sperm donor after intraconjugal ICSI failure].
abstract: OBJECTIVE
  To evaluate the ART results with sperm donation for couples who do not succeed after IC ICSI treatment for male infertility.
  
  
  METHODS
  Retrospective study of 71 couples (November 1994-February 2009). Two control populations were determined to analyse this two-steps treatment (IC and sperm donation) based on different criteria such as the date of ICSI, the female age at the time of the first attempt and the male indication.
  
  
  RESULTS
  In IC-ICSI, the proportion of azoospermic subjects and/or carrying chromosomal abnormalities was significantly higher in the studied population as compared to control. The fertilization rate (FR) and the embryo quality were significantly lower in the studied population. After donation, 30 couples (42.2%) succeeded in being parents. The donor IA pregnancy rates were similar to those of the control population except for the azoospermic patients with poor results. When IVF/ICSI-D was performed, the pregnancy rates were lower than in the control population.
  
  
  CONCLUSIONS
  Sperm donation constitutes an option for half of the couples initially treated with IC-ICSI for male infertility. For couples who failed in sperm donation, a female implication cannot be excluded, even though not detected.
authors.affiliation: Service d'Histologie-Embryologie-Biologie de la Reproduction-CECOS, Université Paris-Descartes, Hôpital Cochin-Saint-Vincent-de-Paul, AP-HP, 27 rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. marie-clemence.leguy@cch.aphp.fr
authors.forename: M-C
authors.initials: MC
authors.lastname: Leguy
authors.forename: J-C
authors.initials: JC
authors.lastname: Juillard
authors.forename: J-M
authors.initials: JM
authors.lastname: Kunstmann
authors.forename: D
authors.initials: D
authors.lastname: de Ziegler
authors.forename: P
authors.initials: P
authors.lastname: Fauque
authors.forename: C
authors.initials: C
authors.lastname: Chalas
authors.forename: J-P
authors.initials: JP
authors.lastname: Wolf
authors.forename: C
authors.initials: C
authors.lastname: Patrat
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000628:therapy*; D002869:Chromosome Aberrations / Q000706:statistics & numerical data; D033001:Directed Tissue Donation; D005260:Female; D005306:Fertilization; D006801:Humans; D007246:Infertility / Q000628:therapy; D007316:Insemination, Artificial, Heterologous; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa; D014019:Tissue Donors; D017211:Treatment Failure