title: Copper-catalyzed cascade synthesis of alkyl 6-aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates.
abstract: A convenient and efficient copper-catalyzed cascade method has been developed for synthesis of benzimidazoisoquinoline derivatives via reactions of readily available substituted 2-(2-halophenyl)benzoimidazoles with alkyl cyanoacetates under mild condition, and the corresponding alkyl 6-aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates were obtained in good to excellent yields. The novel method provides diverse and useful poly N-heterocyclic compounds for combinatorial chemistry and medicinal chemistry.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, P R China.
authors.forename: Juyou
authors.initials: J
authors.lastname: Lu
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
mesh_terms: D000085:Acetates / Q000737:chemistry; D001562:Benzimidazoles / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000085:Acetates; D001562:Benzimidazoles; D007546:Isoquinolines; D003300:Copper