title: Influence of two barrier membranes on staged guided bone regeneration and osseointegration of titanium implants in dogs: part 1. Augmentation using bone graft substitutes and autogenous bone.
abstract: OBJECTIVE
  To assess the influence of two barrier membranes and two bone graft substitutes mixed with autogenous bone (AB) on staged guided bone regeneration and osseointegration of titanium implants in dogs.
  
  
  METHODS
  Four saddle-type defects each were prepared in the upper jaw of six fox hounds and randomly filled with a natural bone mineral (NBM)+AB and a biphasic calcium phosphate (SBC)+AB and allocated to either an in situ gelling polyethylene glycol (PEG) or a collagen membrane (CM). At 8 weeks, modSLA titanium implants were inserted and left to heal in a submerged position. At 8+2 weeks, dissected blocks were processed for histomorphometrical analysis (e.g., treated area [TA], bone-to-implant contact [BIC]).
  
  
  RESULTS
  The mean TA values (mm(2) ) and BIC values (%) tended to be higher in the PEG groups(TA: NBM+AB [10.4 ± 2.5]; SBC+AB [10.4 ± 5.8]/BIC: NBM+AB [86.4 ± 20.1]; SBC+AB [80.1 ± 21.5]) when compared with the corresponding CM groups (TA: NBM+AB [9.7 ± 4.8]; SBC+AB [7.8 ± 4.3]/BIC: NBM+AB [71.3 ± 20.8]; SBC+AB [72.4 ± 20.3]). A significant difference was observed for the mean TA values in the SBC+AB groups.
  
  
  CONCLUSIONS
  It was concluded that all augmentation procedures investigated supported bone regeneration and staged osseointegration of modSLA titanium implants. However, the application of PEG may be associated with increased TA values.
authors.affiliation: Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany. frank.schwarz@med.uni-dueseldorf.de
authors.forename: Frank
authors.initials: F
authors.lastname: Schwarz
authors.forename: Ilja
authors.initials: I
authors.lastname: Mihatovic
authors.forename: Vladimir
authors.initials: V
authors.lastname: Golubovic
authors.forename: Andrea
authors.initials: A
authors.lastname: Hegewald
authors.forename: Jürgen
authors.initials: J
authors.lastname: Becker
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000494:pharmacology; D002130:Calcium Phosphates / Q000494:pharmacology; D003094:Collagen; D003758:Dental Implantation, Endosseous / Q000379:methods*; D004285:Dogs; D048091:Guided Tissue Regeneration / Q000379:methods*; D008437:Maxilla / Q000601:surgery; D008567:Membranes, Artificial; D016348:Osseointegration; D011092:Polyethylene Glycols / Q000494:pharmacology; D011897:Random Allocation; D018709:Statistics, Nonparametric; D013499:Surface Properties; D013524:Surgical Flaps; D014025:Titanium
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D008567:Membranes, Artificial; D011092:Polyethylene Glycols; D003094:Collagen; D014025:Titanium