title: Tissue cadmium accumulation is associated with basal metabolic rate in mice.
abstract: The objective of this study was to examine relations between basal metabolic rate (BMR) and cadmium (Cd) accumulation in the liver, kidneys, and duodenum in mice. The 5-month-old mice selected for high (H) and low (L) BMR were exposed for 8 weeks to 0, 10, and 100 μg Cd/mL of drinking water. The H-BMR mice showed significantly higher concentrations of Cd in the liver (47-79%), kidneys (61-70%), and duodenum (74-100%) than L-BMR animals. The tissue Cd accumulation also positively correlated with the duodenal iron which, in turn, was positively associated with BMR (Spearman R                         (s) = 0.81, P = 0.0004). The data indicate that tissue accumulation of Cd in mice is linked to BMR; the correlation between tissue Cd and duodenal iron suggests an involvement of iron transport pathway in the accumulation of Cd.
authors.affiliation: Institute of Biology, University of Białystok, Świerkowa 20B, 15-950, Białystok, Poland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Maciak
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Włostowski
authors.forename: Aneta
authors.initials: A
authors.lastname: Salińska
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Bonda-Ostaszewska
mesh_terms: D000818:Animals; D001481:Basal Metabolism / Q000187:drug effects*; D001835:Body Weight / Q000502:physiology; D002104:Cadmium / Q000378:metabolism* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D060766:Drinking Water; D004386:Duodenum / Q000378:metabolism; D007501:Iron / Q000502:physiology; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D009752:Nutritional Status; D009929:Organ Size / Q000502:physiology; D013054:Spectrophotometry, Atomic
chemical_list: D060766:Drinking Water; D002104:Cadmium; D007501:Iron