title: [Research progress in the relationship between TRPV1 and visceral hypersensitivity in functional gastrointestinal diseases].
abstract: Transient receptor potential vanilloid 1(TRPV1) is a nonselective cation channel with high permeability for Ca(2+). It may play a role in the development and maintenance of visceral pain and hypersensitivity states, which has generated a major interest in the development of specific vanilloid antagonists. In this review, a summary of the contribution of TRPV1 in the development of visceral hypersensitivity in functional dyspepsia and irritable bowel syndrome is presented with the structure, location, and related molecular mechanisms.
authors.affiliation: Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Li
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Duan
mesh_terms: D004415:Dyspepsia / Q000378:metabolism*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism*; D059265:Visceral Pain / Q000209:etiology / Q000378:metabolism*
chemical_list: D050916:TRPV Cation Channels; C494482:TRPV1 protein, human