title: [Efficacy and safety of high dose (≥8 mg/kg/day) daptomycin].
abstract: BACKGROUND
  There is a paucity of data regarding efficacy and safety of high dose (>8mg/kg/day) daptomycin.
  
  
  METHODS
  This ambispective study included all patients that received ≥8 mg/kg/day of daptomycin and had efficacy and safety data.
  
  
  RESULTS
  Sixty-nine patients were included. Fifty-nine patients (85.5%) were recorded as having been cured or improved. Six patients (8.6%) had a raised CPK during follow-up with no clinical signs of myopathy in any of them.
  
  
  CONCLUSIONS
  High dose daptomycin shows good efficacy without concerns about toxicity.
authors.affiliation: Unidad de Enfermedades Infecciosas, Hospital Universitario San Cecilio, Granada, Spain. jordi@ugr.es
authors.forename: Jorge
authors.initials: J
authors.lastname: Parra-Ruiz
authors.forename: Alejandro
authors.initials: A
authors.lastname: Peña-Monje
authors.forename: Cristina
authors.initials: C
authors.lastname: Tomás-Jiménez
authors.forename: José
authors.initials: J
authors.lastname: Pomares-Mora
authors.forename: José
authors.initials: J
authors.lastname: Hernández-Quero
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D017576:Daptomycin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin