title: Control of nuclear receptor function by local chromatin structure.
abstract: Steroid hormone receptors regulate gene transcription in a highly tissue-specific manner. The local chromatin structure underlying promoters and hormone response elements is a major component involved in controlling these highly restricted expression patterns. Chromatin remodeling complexes, as well as histone and DNA modifying enzymes, are directed to gene-specific regions and create permissive or repressive chromatin environments. These structures further enable proper communication between transcription factors, co-regulators and basic transcription machinery. The regulatory elements active at target genes can be either constitutively accessible to receptors or subject to rapid receptor-dependent modification. The chromatin states responsible for these processes are in turn determined during development and differentiation. Thus access of regulatory factors to elements in chromatin provides a major level of cell selective regulation.
authors.affiliation: Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD 20892-5055, USA.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wiench
authors.forename: Tina B
authors.initials: TB
authors.lastname: Miranda
authors.forename: Gordon L
authors.initials: GL
authors.lastname: Hager
mesh_terms: D000818:Animals; D002843:Chromatin / Q000502:physiology* / Q000648:ultrastructure*; D005786:Gene Expression Regulation; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*
chemical_list: D002843:Chromatin; D018160:Receptors, Cytoplasmic and Nuclear