title: Protective effect of Fucoxanthin against UVB-induced skin photoaging in hairless mice.
abstract: Fucoxanthin, a major carotenoid in brown algae, has various beneficial effects. In this study, we evaluated the effect of topical fucoxanthin on UVB-induced skin photoaging in hairless mice. The dorsal skins were treated topically with a 0.001% fucoxanthin solution 2 h each time before UVB irradiation (5 times a week) for 10 weeks. The formation of wrinkles in UVB-irradiated skin treated with vehicle alone significantly increased, as compared with the non-irradiated control. Treatment with fucoxanthin tended to suppress UVB-induced wrinkle formation, but there was no significant difference between wrinkle formation in the control group and the fucoxanthin treatment group. However, topical treatment with fucoxanthin significantly lessened UVB-induced epidermal hypertrophy, VEGF, and MMP-13 expression in the epidermis and thiobarbituric acid reactive substances (TBARS) in the skin. These results indicate that topical treatment with fucoxanthin prevents skin photoaging in UVB-irradiated hairless mice, possibly via antioxidant and antiangiogenic effects.
authors.affiliation: Graduate School of Agriculture, Kyoto University, Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Urikura
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sugawara
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirata
mesh_terms: D000287:Administration, Topical; D000818:Animals; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008812:Mice, Hairless; D015595:Skin Aging / Q000187:drug effects* / Q000235:genetics / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D024341:Xanthophylls / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D024341:Xanthophylls; C025164:fucoxanthin