title: Elevated muscle enzymes and muscle biopsy in idiopathic hypoparathyroidism patients.
abstract: OBJECTIVE
  To study idiopathic hypoparathyroidism (IHP) myopathy and its pathogenesis by histology method.
  
  
  METHODS
  We retrospectively analyzed the clinical data of nine IHP patients during the years 2006-2010.
  
  
  RESULTS
  We found that: 1) there was an inverse relationship between the decreased serum calcium level and the elevated muscle enzymes level; 2) the IHP patients had mild-to-moderate muscle cells vacuolar degeneration and focal hyaline degeneration by hematoxylin-eosin (HE) staining; 3) except for 2 patients, the others' muscles striations were undetectable by phosphotungstic acid hematoxylin staining; 4) 2 patients with extremely high level of creatine kinase and relatively longer disease duration had muscle atrophy, multiple focal muscle fiber hyaline degeneration and sarcolemma cells hyperplasia by HE staining; 5) all patients had different degree of immune complex deposition along the muscle cell membranes by immunofluorescence staining.
  
  
  CONCLUSIONS
  The patients with IHP had some histological changes in skeletal muscles but with no specificity. The changes in muscles and the elevated serum muscle enzymes were related to hypocalcemia. The severity of changes in muscles was related to the duration of hypocalcemia and not only to its degree.
authors.affiliation: Endocrinology Department, General Hospital of Tianjin Medical University, Tianjin, China. daiandzhang@sina.com
authors.forename: C L
authors.initials: CL
authors.lastname: Dai
authors.forename: C
authors.initials: C
authors.lastname: Dai
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Sun
authors.forename: Z
authors.initials: Z
authors.lastname: Sun
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: M C
authors.initials: MC
authors.lastname: Qiu
authors.forename: M
authors.initials: M
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002130:Calcium Phosphates / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D006996:Hypocalcemia / Q000378:metabolism* / Q000473:pathology*; D007011:Hypoparathyroidism / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000201:enzymology / Q000473:pathology; D018482:Muscle, Skeletal / Q000201:enzymology* / Q000473:pathology*; D012508:Sarcolemma / Q000378:metabolism; D014617:Vacuoles / Q000473:pathology; D055815:Young Adult
chemical_list: D002130:Calcium Phosphates; D003402:Creatine Kinase