title: Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus.
abstract: OBJECTIVE
  Many investigations have focused the association between TNF 308 G/A polymorphism and risk for type 2 diabetes mellitus (T2DM). However, the sample sizes of most of the studies were small. The aim of this study is to evaluate the precise association between this variant and risk for T2DM in a large-scale meta-analysis.
  
  
  METHODS
  All publications were searched on the association between TNF 308 G/A polymorphism and T2DM. The key words were as follows: diabetes, tumor necrosis factor and polymorphism/variant/genotype. This meta-analysis was assessed by Review manager 5.0.
  
  
  RESULTS
  There were 18 studies identified. The odds ratios (ORs) and 95% confidence intervals (CI) for GA+AA versus GG genotype of TNF 308 G/A polymorphism were 1.03 (0.95-1.12), 1.03 (0.94-1.13) and 1.03 (0.78-1.36) in overall, Caucasian and Asian populations, respectively. The sensitivity analysis further strengthened the validity of this association. No publication bias or heterogeneity was observed in this study.
  
  
  CONCLUSIONS
  In summary, there was no significant association detected between the TNF 308 G/A polymorphism and risk for T2DM.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
authors.forename: Ren-Nan
authors.initials: RN
authors.lastname: Feng
authors.forename: Chen
authors.initials: C
authors.lastname: Zhao
authors.forename: Chang-Hao
authors.initials: CH
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha