title: C-C (alkynylation) vs C-O (ether) bond formation under Pd/C-Cu catalysis: synthesis and pharmacological evaluation of 4-alkynylthieno[2,3-d]pyrimidines.
abstract: The Pd/C-CuI-PPh(3) catalytic system facilitated C-C bond formation between 4-chlorothieno[2,3-d]pyrimidines and terminal alkynes in methanol with high selectivity without generating any significant side products arising from C-O bond formation between the chloro compounds and methanol. A variety of novel 4-alkynylthieno[2,3- d]pyrimidines were prepared via alkynylation of 4-chlorothieno[2,3-d]pyrimidines in good to excellent yields. Some of the compounds synthesized were tested for cytotoxic activity in vitro.
authors.affiliation: Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad-500 046, India.
authors.forename: Dhilli Rao
authors.initials: DR
authors.lastname: Gorja
authors.forename: K Shiva
authors.initials: KS
authors.lastname: Kumar
authors.forename: K
authors.initials: K
authors.lastname: Mukkanti
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal