title: Second line chemotherapy in patients with enteropathy-associated T cell lymphoma: a retrospective single center analysis.
abstract: Enteropathy-associated T cell lymphoma (EATL) is a rare disease with a dismal prognosis. Due to the low efficacy of chemotherapy and the poor performance status of patients failing first line, no data on second line therapy exist. A retrospective analysis of 19 patients with EATL at our institution identified six patients (31%) undergoing second line chemotherapy after CHOP-like regimens. Three patients had progressive disease (PD) during first line therapy, while the other three patients showed relapse after an initial complete remission (CR). The time from the last cycle of first line chemotherapy to second line therapy was 1-62 months. Two patients received ifosfamide, carboplatin and etoposide (ICE), two were given fludarabine and cyclophosphamide (FC) and one each had dexamethasone, cisplatin and cytarabine (DHAP) and cladribine chemotherapy. One patient progressed after one course of cladribine, while two patients developed intestinal perforation and died after one course of ICE and DHAP, respectively. Three patients achieved a CR lasting 4, +7 and +64 months, with two being alive without evidence of disease. Our data again confirm the poor prognosis of patients with EATL. A small subset of patients, however, apparently benefits from initiation of second line chemotherapy.
authors.affiliation: Department of Internal Medicine I, Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. markus.raderer@meduniwien.ac.at
authors.forename: Markus
authors.initials: M
authors.lastname: Raderer
authors.forename: Marlene
authors.initials: M
authors.lastname: Troch
authors.forename: Barbara
authors.initials: B
authors.lastname: Kiesewetter
authors.forename: Andreas
authors.initials: A
authors.lastname: Püspök
authors.forename: Ulrich
authors.initials: U
authors.lastname: Jaeger
authors.forename: Martha
authors.initials: M
authors.lastname: Hoffmann
authors.forename: Andreas
authors.initials: A
authors.lastname: Chott
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D058527:Enteropathy-Associated T-Cell Lymphoma / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D016896:Treatment Outcome