title: Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice.
abstract: Liposomal encapsulation of doxorubicin (DXR) improves tumor accumulation and reduces adverse effects. One possible strategy for further optimization of this delivery technology would be to design the liposome carrier to release its content within the tumor tissue in response to specific stimuli such as ultrasound (US). In this study, the tumor uptake properties and therapeutic efficacy of 1,2 distearoyl-sn-glycero-3-phosphatidylethanolamine-based liposomes containing DXR were investigated in nude mice bearing tumor xenografts. The liposomal DXR formulation alone showed no inhibitory effect on tumor growth. However, upon exposure to low frequency US in situ inhibition of tumor growth was demonstrated.
authors.affiliation: Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
authors.forename: Eirik
authors.initials: E
authors.lastname: Hagtvet
authors.forename: Tove J
authors.initials: TJ
authors.lastname: Evjen
authors.forename: Dag Rune
authors.initials: DR
authors.lastname: Olsen
authors.forename: Sigrid L
authors.initials: SL
authors.lastname: Fossheim
authors.forename: Esben A
authors.initials: EA
authors.lastname: Nilssen
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D008081:Liposomes; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D015612:Phonophoresis / Q000379:methods*; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D014018:Tissue Distribution; D023041:Xenograft Model Antitumor Assays
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D008081:Liposomes; D010714:Phosphatidylethanolamines; C038089:1,2-distearoylphosphatidylethanolamine; D004317:Doxorubicin