title: Prediction of recovery time from hypoglycemia in patients with insulin overdose.
abstract: Insulin overdose results in prolonged hypoglycemia. We hypothesized that if a huge amount of insulin is subcutaneously injected, the duration of hypoglycemia depends on the dose of insulin rather than the type of insulin. We conducted a literature review of insulin overdose and 33 cases were included in this study. We assessed the correlation between recovery time from hypoglycemia and insulin dose. As a result, there was a significant correlation between recovery time from hypoglycemia and insulin dose (r=0.88, p<0.0001) and this correlation was expressed as y=0.045x; where y is time (h) and x is insulin dose (U), corresponding to that if 1000 U insulin is injected, hypoglycemia will persist for ~45 h. This equation may be useful to predict the duration of glucose supplementation for treatment of insulin overdose.
authors.affiliation: Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Ohyama
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Saisho
authors.forename: Ayako
authors.initials: A
authors.lastname: Muraki
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kawai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
mesh_terms: D000328:Adult; D000368:Aged; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin / Q000008:administration & dosage / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D007328:Insulin