title: Uteroglobulin-related protein 1 and severity of respiratory syncytial virus infection in children admitted to hospital.
abstract: There are several reports suggesting that genetic factors contribute to the severity of infection with the respiratory syncytial virus (RSV). Infants hospitalized with lower respiratory tract infection (LRTI) due to RSV are at a significantly increased risk for both recurrent wheezing and childhood asthma. Uteroglobin-related protein 1 (UGRP1) is a secretory protein expressed in the airways, and speculated to have anti-inflammatory activity. The presence of the -112G/A polymorphism in the UGRP1 promoter was found to have a significant correlation with asthma phenotype. Also plasma UGRP1 levels were shown to be associated both with this polymorphism and the severity of asthma. The study population consisted of 62 previously healthy infants, ≤12 months of age, who were hospitalized with RSV LRTI, and a control group of 99 healthy adults. Genotyping was performed by restriction fragment length polymorphism. UGRP1 serum levels were determined using ELISA. There were no significant differences in the overall distribution of UGRP1 -112G/A polymorphism genotypes or alleles between the hospitalized infants and healthy adults. A comparison of serum UGRP1 concentration measured at the time of admission and discharge between patients with and without the -112A allele revealed that there was no relation between the presence of the -112A allele and serum UGRP1 in hospitalized infants with RSV infection. Furthermore, there was no relationship between severity of RSV infection and genotype or serum UGRP1 concentration. These results suggest that UGRP1 does not have a major role in the development of severe RSV infection.
authors.affiliation: Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima, Japan. don@fmu.ac.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Katayose
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sakuma
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Sumikoshi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakata
authors.forename: Masatoki
authors.initials: M
authors.lastname: Sato
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ohara
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Abe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Watanabe
authors.forename: Toshiko
authors.initials: T
authors.lastname: Sato
authors.forename: Kei
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Suzutani
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Munakata
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Hosoya
mesh_terms: D000328:Adult; D000483:Alleles; D001249:Asthma / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012135:Respiratory Sounds / Q000235:genetics; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D012136:Respiratory Syncytial Viruses / Q000235:genetics / Q000472:pathogenicity*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D060765:Secretoglobins / Q000097:blood / Q000235:genetics* / Q000276:immunology; D012720:Severity of Illness Index
chemical_list: C449940:SCGB3A2 protein, human; D060765:Secretoglobins