title: Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population.
abstract: Methamphetamine (MAP) dependence is a highly heritable and aberrant dopaminergic signaling that has been implicated in the disease. Glial cell line-derived neurotrophic factor (GDNF), which plays an important role in the survival of dopaminergic neurons, may be involved in this disorder. In this study, we examined the association between GDNF and MAP dependence using a Japanese population-based sample. We selected eight single nucleotide polymorphisms (SNPs) in the GDNF locus for the association analysis. When patients with MAP dependence were divided into two subgroups consisting of multi-substance and MAP-only users, we detected a significant association between these two groups and the tagging SNP, rs2910704 (after Bonferroni's correction; allele P=0.034). Thus, GDNF is likely to be related to the severity of MAP use in the Japanese population.
authors.affiliation: Division of Clinical Science and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, Aichi, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Hinako
authors.initials: H
authors.lastname: Usui
authors.forename: Nagahide
authors.initials: N
authors.lastname: Takahashi
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshimi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Saito
authors.forename: Branko
authors.initials: B
authors.lastname: Aleksic
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Yamada
authors.forename: Naohisa
authors.initials: N
authors.lastname: Uchimura
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sora
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
mesh_terms: D000483:Alleles; D019969:Amphetamine-Related Disorders / Q000453:epidemiology / Q000235:genetics*; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D004298:Dopamine / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D016324:Sequence Tagged Sites; D015398:Signal Transduction / Q000502:physiology
chemical_list: D051100:Glial Cell Line-Derived Neurotrophic Factor; D004298:Dopamine