title: Targeting cancer cells through iron(III) complexes of di(picolyl)amine modified silica core-shell nanospheres.
abstract: In this report, we aim at optimizing the approach of delivering and imaging cancer cell targeting using anti-proliferative nanoparticle complex. Rhodamine B isothiocyanate doped silica-coated (RBITC-SiO₂) were prepared by microemulsion method. Fe(III) complex of di(picolyl)amine was conjugated on to the surface RBITC-SiO₂ to produce final nanosphere (RBITC-SiO₂ @dpa-Fe) with an average hydrodynamic diameter of 74 nm. The Fe(III)-di(picolyl)amine complex modified nanospheres displayed enhanced HeLa cells uptake in vitro suggesting selective cancer cell payload delivery. RBITC-SiO₂ @dpa-Fe also showed reduced off-target cytotoxicity. The conjugate of dpa-Fe(III) complex and fluorescence core-shell nanoparticles RBITC-SiO₂ represents a class of novel multi-functional nanoparticles that combines the advantages of active cancer-targeting through Fe(III) complex mediated intracellular drug delivery and compatibility with fluorescence imaging.
authors.affiliation: School of Chemistry and Chemical Engineer, Jiangsu University, Zhenjiang, 212013, PR China.
authors.forename: Gen-Ping
authors.initials: GP
authors.lastname: Tao
authors.forename: Qiu-Yun
authors.initials: QY
authors.lastname: Chen
authors.forename: Xia
authors.initials: X
authors.lastname: Yang
authors.forename: Kai-Di
authors.initials: KD
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
mesh_terms: D000588:Amines / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D005290:Ferric Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D054118:Nanospheres / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry / Q000494:pharmacology; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000588:Amines; D005290:Ferric Compounds; D012235:Rhodamines; D012822:Silicon Dioxide; C027755:rhodamine isothiocyanate