title: Optimization of parameters of the SeDeM Diagram Expert System: Hausner index (IH) and relative humidity (%RH).
abstract: As a methodology for characterizing substances in relation to their viability in direct compression, the SeDeM Diagram Expert System may be considered an open system in terms of the number of parameters applied and the optimization of these parameters. With the experience acquired from applying the SeDeM Diagram, in this study, we propose optimizing the parameters corresponding to the Hausner index (IH) and relative humidity (%HR) in order to simplify the mathematical calculation, so that it provides reliable data that can be extrapolated. The proposed optimization does not involve a conceptual change in the parameters considered nor a significant change in the results obtained compared with the previous calculation methodology initially established for the SeDeM Diagram Expert System, which means that the conclusions obtained by applying this method are equivalent.
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Josep M
authors.initials: JM
authors.lastname: Suñé-Negre
authors.forename: Pilar
authors.initials: P
authors.lastname: Pérez-Lozano
authors.forename: Manel
authors.initials: M
authors.lastname: Roig
authors.forename: Roser
authors.initials: R
authors.lastname: Fuster
authors.forename: Carmen
authors.initials: C
authors.lastname: Hernández
authors.forename: Ramon
authors.initials: R
authors.lastname: Ruhí
authors.forename: Encarna
authors.initials: E
authors.lastname: García-Montoya
authors.forename: Montserrat
authors.initials: M
authors.lastname: Miñarro
authors.forename: Josep R
authors.initials: JR
authors.lastname: Ticó
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004339:Drug Compounding / Q000379:methods*; D005079:Excipients / Q000737:chemistry; D005103:Expert Systems; D006813:Humidity; D008432:Mathematical Computing; D011208:Powders / Q000737:chemistry; D013607:Tablets / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D005079:Excipients; D011208:Powders; D013607:Tablets