title: Palladium-catalyzed regioselective silaboration of pyridines leading to the synthesis of silylated dihydropyridines.
abstract: The addition of silylboronic esters to pyridine takes place in toluene at 50 °C in the presence of a palladium catalyst to give N-boryl-4-silyl-1,4-dihydropyridines in high yield. The regioselective 1,4-silaboration also proceeds in the reaction of 2-picoline and 3-substituted pyridines, whereas 4-substituted pyridines undergo 1,2-silaboration to give N-boryl-2-silyl-1,2-dihydropyridines regioselectively.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Oshima
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Ohmura
authors.forename: Michinori
authors.initials: M
authors.lastname: Suginome