title: Comparison of diazinon toxicity to embryos of Xenopus laevis and Danio rerio; degradation of diazinon in water.
abstract: The aim of this study was to determine the toxic effect of diazinon (organophosphate insecticide) to embryos of Xenopus laevis and Danio rerio. The 96-h LC₅₀ values showed higher toxicity of diazinon for X. leavis in standard solution (9.84 mg/L) compared to the pond water (12.64 mg/L). Teratogenic index for diazinon was 1.3 and 1.6, respectively. The 96-h LC₅₀ diazinon values demonstrated similar sensitivity of embryos D. rerio (8.21-9.34 mg/L) and X. laevis in standard test solutions. Our results reflect that direct application of diazinon into the water can be associated with significant risks to aquatic organisms.
authors.affiliation: Department of Veterinary Public Health and Toxicology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1-3, 61242 Brno, Czech Republic. modrah@vfu.cz
authors.forename: Helena
authors.initials: H
authors.lastname: Modra
authors.forename: Dagmar
authors.initials: D
authors.lastname: Vrskova
authors.forename: Stanislava
authors.initials: S
authors.lastname: Macova
authors.forename: Jana
authors.initials: J
authors.lastname: Kohoutkova
authors.forename: Jana
authors.initials: J
authors.lastname: Hajslova
authors.forename: Ivana
authors.initials: I
authors.lastname: Haluzova
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Svobodova
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D003976:Diazinon / Q000378:metabolism / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004625:Embryo, Nonmammalian / Q000187:drug effects* / Q000378:metabolism; D007306:Insecticides / Q000378:metabolism / Q000633:toxicity*; D014871:Water Microbiology; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000633:toxicity*; D014982:Xenopus laevis / Q000196:embryology / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism
chemical_list: D007306:Insecticides; D014874:Water Pollutants, Chemical; D003976:Diazinon