title: [Postoperative delirium is associated with cognitive dysfunction one week after coronary artery bypass grafting surgery].
abstract: OBJECTIVE
  To investigate the relationship between postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) after coronary artery bypass graft in Chinese population.
  
  
  METHODS
  One hundred and seven patients who were referred for elective coronary artery bypass grafting (CABG) surgery were enrolled in this prospective cohort study. Baseline and perioperative variables as well as occurrence of postoperative complications were recorded. POD was diagnosed using the Confusion Assessment Method for the Intensive Care Unit twice daily during the first seven postoperative days. A neuropsychological test battery that included 7 tests with 9 subscales was administered at baseline and on the seventh day after surgery. POCD was defined using the same definition that was used in the ISPOCD1 study.
  
  
  RESULTS
  The incidence of POD was 47.7% (51/107) while that of POCD was 55.3% (57/103). Multivariate Logistic regression analyses identified four independent risk factors of POD, i.e., increasing age (OR 1.174, 95% CI 1.085-1.269, P<0.001), preoperative history of diabetes mellitus (OR 4.224, 95% CI 1.543-11.563, P=0.005), occurrence of postoperative complications (OR 3.667, 95% CI 1.152-11.670, P=0.028), and prolonged duration of intensive care unit stay (OR 1.024, 95% CI 1.005-1.044, P=0.016). And two independent risk factors of POCD were identified, i.e., increasing age (OR 1.065, 95% CI 1.001-1.134, P=0.047) and prolonged duration of POD (OR 1.744, 95% CI 1.173-2.593, P=0.006).
  
  
  CONCLUSIONS
  POD and POCD are common cognitive complications after CABG surgery in Chinese population. Prolonged duration of POD is an independent risk factor of the occurrence of POCD.
authors.affiliation: Department of Anesthesiology and Surgical Intensive Care, Peking University First Hospital, Beijing 100034, China.
authors.forename: Dong-liang
authors.initials: DL
authors.lastname: Mu
authors.forename: Dong-xin
authors.initials: DX
authors.lastname: Wang
authors.forename: Li-huan
authors.initials: LH
authors.lastname: Li
authors.forename: Guo-jin
authors.initials: GJ
authors.lastname: Shan
authors.forename: Yu
authors.initials: Y
authors.lastname: Su
authors.forename: Qin-jun
authors.initials: QJ
authors.lastname: Yu
authors.forename: Chun-xia
authors.initials: CX
authors.lastname: Shi
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003693:Delirium / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors