title: [Changes in the activity of the ciliary apparatus of the cerebral aqueduct ependymal cells induced by some cerebrospinal fluid neurotransmitters].
abstract: In vitro investigation of the effect of the neurotransmitter amino acids on motile activity of the ciliary apparatus of cerebral (Sylvian) aqueduct ependymal cells in the newborn rats has shown that the addition of glutamate, GABA, glycine, and taurine to the nutrient medium induced deceleration and, finally, complete disappearance of motile activity of the ciliary apparatus. Inhibition and blocking of the ciliary activity induced by the neurotransmitters, especially by high concentrations of glutamate, indicate the existence of respective receptors on the membrane of the cerebral aqueduct ependymal cells. This involvement of the receptors was confirmed in the experiments with the preliminary introduction of ion channel blockers (ketamine, strychnine, and bicuculine) into the culture medium that resulted in the attenuation of neurotransmitter destructive effect and the prolongation of motile activity of the ciliary apparatus.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D002923:Cilia / Q000378:metabolism; D004805:Ependyma / Q000166:cytology / Q000378:metabolism*; D049990:Membrane Transport Modulators / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats
chemical_list: D049990:Membrane Transport Modulators; D018377:Neurotransmitter Agents