title: [Immunomodulators for topical application to prevent and manage chronic adenoiditis in children].
abstract: The authors report the results of a study on the efficacy of topical application of the immunomodulator IRS 19 in children presenting with chronic adenoiditis and grade I-III hypertrophy of adenoid vegetation. The use of this preparation is shown to faster and more efficaciously normalize the volume of the lymphoid tissue than irrigation of the nasopharynx with saline solutions. Moreover, the treatment of chronic adenoiditis with IRS 19 promoted normalization of biocenosis of the nasopharyngeal secretion and significantly decreased the abundance of pathogenic microflora. Specifically, the overall frequency of exacerbations and the frequency of exacerbations of adenoiditis decreased three- and two-fold respectively while the duration of the disease shortened. It is recommended that the topical immunomodulator IRS 19 should be included in the programs of planned seasonal treatment of children suffering chronic adenoiditis (to be applied at least 2-3 times annually).
authors.forename: T I
authors.initials: TI
authors.lastname: Garashchenko
authors.forename: I V
authors.initials: IV
authors.lastname: Zelenkova
authors.forename: M V
authors.initials: MV
authors.lastname: Alferova
mesh_terms: D000234:Adenoids / Q000187:drug effects / Q000473:pathology*; D000287:Administration, Topical; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D006984:Hypertrophy / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control; D007155:Immunologic Factors / Q000008:administration & dosage*; D009304:Nasopharyngitis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D007155:Immunologic Factors