title: Hybridization-sensitive fluorescence control in the near-infrared wavelength range.
abstract: A series of near-infrared fluorescent probes were designed based on the concept of emission control caused by interdye excitonic interaction. The fluorescent probes showed very weak emission in the unhybridized state, whereas they emitted near-infrared fluorescence after hybridization with the complementary nucleic acid. The hybridization-dependent switching of fluorescence emission made it possible to monitor mRNA in human cells in the range of near-infrared wavelengths.
authors.affiliation: Advanced Science Institute, RIKEN, Wako, Saitama 351-0198, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Ikeda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yanagisawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakamura
authors.forename: Dan Ohtan
authors.initials: DO
authors.lastname: Wang
authors.forename: Mizue
authors.initials: M
authors.lastname: Yuki
authors.forename: Akimitsu
authors.initials: A
authors.lastname: Okamoto
mesh_terms: D002478:Cells, Cultured; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D012333:RNA, Messenger / Q000032:analysis; D013237:Stereoisomerism
chemical_list: D005456:Fluorescent Dyes; D012333:RNA, Messenger