title: [Expression of T-bet and its regulation on CD4(+) T cell polarization in aplastic anemia].
abstract: Aplastic anemia (AA) is an autoimmune disease which take hematopoietic tissue as target cells. T lymphocyte-mediated cellular immune abnormality plays a key role in the pathogenesis of AA. Increase and hyperfunction of Thl lymphocytes are main feature of AA disease. The recent studies indicated that T-bet is Th1 cell-specific transcription factor, is crucial factor for polarization of CD4(+) T lymphocytes to Th1. High expression of T-bet in AA patients is an important link in pathogenesis of AA. In this article, T-bet and its relation with AA, including expression of T-bet in AA patients, the regulation of T-bet on polarization of CD4(+) T lymphocytes are reviewed.
authors.affiliation: Department of Hematology, Shanxi Medical University Second Clinical Medical College, Taiyuan 030001, Shanxi Province, China.
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Wang
authors.forename: Wu
authors.initials: W
authors.lastname: Wei
mesh_terms: D000741:Anemia, Aplastic / Q000097:blood* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D018655:Lymphocyte Count; D020825:T-Box Domain Proteins / Q000276:immunology / Q000378:metabolism*; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D000098815:T-bet Transcription Factor
chemical_list: D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor