title: Mimecan is involved in aortic hypertrophy induced by sinoaortic denervation in rats.
abstract: This study was designed to investigate whether mimecan was involved in aortic hypertrophy induced by sinoaortic denervation in rats. 8 weeks after sinoaortic denervation, when compared to sham-operated rats, sinoaortic denervated rats exhibited aortic hypertrophy and down-regulation of mimecan. Through classic univariate correlation analysis, it was found that mimecan mRNA was negatively related to extent of aortic hypertrophy. Treatment of primary cultured vascular smooth muscle cells with the Ang II (1 μM), which was found locally increased in the aortae of sinoaortic denervated rats, resulted in a reduction of mimecan expression. In vitro, knockdown of mimecan in vascular smooth muscle cells promoted cell proliferation induced by 15% of fetal bovine serum or Ang II (1 μM). We concluded that down-regulation of mimecan was involved in aortic hypertrophy induced by sinoaortic denervation in rats.
authors.affiliation: Department of Cardiovascular Diseases, Changhai Hospital, Second Military Medical University, 800 Xiang Yin Road, Shanghai, 200433, China.
authors.forename: Xiao-Song
authors.initials: XS
authors.lastname: Gu
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Lei
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Shi
authors.forename: Wen-ling
authors.initials: WL
authors.lastname: Lian
authors.forename: Xiang
authors.initials: X
authors.lastname: Yang
authors.forename: Xing
authors.initials: X
authors.lastname: Zheng
authors.forename: Yong-Wen
authors.initials: YW
authors.lastname: Qin
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000473:pathology; D003714:Denervation / Q000379:methods*; D006023:Glycoproteins / Q000494:pharmacology*; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012849:Sinoatrial Node / Q000294:innervation*
chemical_list: D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; C512905:Ogn protein, rat