title: Phosphane-free green protocol for selective nitro reduction with an iron-based catalyst.
abstract: Iron phthalocyanine with iron sulfate has been successfully applied for high chemo- and regioselective reduction of aromatic nitro compounds to give the corresponding amines in a green solvent system without using any toxic ligand. The catalytic systems were also compatible with a large range of other reducible functional groups, such as keto, acid, amide, ester, halogen, lactone, nitrile, N-benzyl, O-benzyl, hydroxy, and heterocycles. In the present study, dinitro compounds have been regioselectively reduced to the corresponding amines with high yield. In most of the cases the conversion and selectivity was greater than 99% as determined by GC-MS analysis.
authors.affiliation: Natural Plant Products Division, Institute of Himalayan Bioresource Technology (Council of Scientific & Industrial Research), Palampur, Himachal Pradesh, 176 061, India.
authors.forename: Upendra
authors.initials: U
authors.lastname: Sharma
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Verma
authors.forename: Neeraj
authors.initials: N
authors.lastname: Kumar
authors.forename: Vishal
authors.initials: V
authors.lastname: Kumar
authors.forename: Manju
authors.initials: M
authors.lastname: Bala
authors.forename: Bikram
authors.initials: B
authors.lastname: Singh
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D005296:Ferrous Compounds; D006571:Heterocyclic Compounds; D006834:Hydrazines; D007211:Indoles; D010720:Phosphines; C493990:iron phthalocyanine; D007501:Iron; C044646:phosphine