title: [The human variome project and its progress].
abstract: The main goal of post genomics is to explain how the genome, the map of which has been constructed in the Human Genome Project, affacts activities of life. This leads to generate multiple "omics": structural genomics, functional genomics, proteomics, metabonomics, et al. In Jun. 2006, Melbourne, Australia, Human Genome Variation Society (HGVS) initiated the Human Variome Project (HVP) to collect all the sequence variation and polymorphism data worldwidely. HVP is to search and determine those mutations related with human diseases by association study between genetype and phenotype on the scale of genome level and other methods. Those results will be translated into clinical application. Considering the potential effects of this project on human health, this paper introduced its origin and main content in detail and discussed its meaning and prospect.
authors.affiliation: College of Life Science, Nankai University, Tianjin 300071, China. gao_shan@mail.nankai.edu.cn
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Guang-You
authors.initials: GY
authors.lastname: Duan
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
mesh_terms: D030541:Databases, Genetic; D014644:Genetic Variation; D023281:Genomics; D016045:Human Genome Project; D006801:Humans; D012984:Software