title: [Clinical analysis of malignant submandibular tumor].
abstract: The 14 cases of malignant submandibular tumor whose treatment outcome we analyzed between 1989 and 2008 included 5 of adenoid cystic carcinoma, 3 of squamous cell carcinoma, 2 each of mucoepidermoid carcinoma, and carcinoma ex pleomorphic adenoma, and 1 each of carcinosarcoma and large-cell carcinoma. One subject was diagnosed with T1, 7 with T2, 4 with T3, and 2 with T4. Lymph node involvement occurred in 5, -1 with N1 and 4 with N2. None had distant metastasis on the first visit. Seven were treated by surgery alone, 3 by surgery followed by radiotherapy, 2 by surgery followed by radio-and chemotherapy, and 1 by optimized supportive care. The surgical resection area was decided by tumor extension. Neck dissection was done in 9. Overall 5-year survival for all cases based on the Kaplan-Meier method was 57%. All with carcinoma ex pleomorphic adenoma, carcinosarcoma, or large-cell carcinoma remain alive. For those with adenoid cystic carcinoma 5-year survival is 80%, with mucoepidermoid carcinoma 50%, with squamous cell carcinoma 0%, and with carcinosarcoma 0%, respectively. The 5-year survival for stage I subjects was 100%, for stage II 83%, for stage III 50%, and for stage IV 0%. Surgical resection and postoperative radiotherapy were done in cases of minimal extraglandular extension or microscopically positive margins, with satisfactory results. Treatment efficacy for high-grade and advanced stage, however, requires more improvement.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kitao
authors.forename: Akihiro
authors.initials: A
authors.lastname: Homma
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Oridate
authors.forename: Seigo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Suzuki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kano
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Mizumachi
authors.forename: Shigenari
authors.initials: S
authors.lastname: Taki
authors.forename: Naoya
authors.initials: N
authors.lastname: Inamura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuda
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013362:Sublingual Gland Neoplasms / Q000628:therapy*; D016896:Treatment Outcome