title: Effect of selenium pre-treatment on plasma antioxidant vitamins A (retinol) and E (α-tocopherol) in static magnetic field-exposed rats.
abstract: In the present study, we evaluate the effect of the co-exposure to static magnetic field (SMF) and selenium (Se) on the antioxidant vitamins A and E levels and some other parameters of oxidative stress in rat. Sub-acute exposure of male adult rats to a uniform SMF (128 mT, 1 h/day during 5 consecutive days) increased plasma activity of glutathione peroxidase (+35%) but decreased α-tocopherol (-67%) and retinol levels (-41%). SMF exposure failed to alter the plasmatic thiobarbituric acid-reactive species (TBARs), total thiol groups and selenium concentrations. Sub-chronic administration of Se (Na(2)SeO(3), 0.2 mg/L, for 30 consecutive days, per os) ameliorated the antioxidant capacities in SMF-treated rats. Our investigation demonstrated that sub-acute exposure to SMF induced oxidative stress, which may be prevented by a pretreatment with selenium.
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Jarzouna, Tunisia. ghodhbanes@yahoo.fr
authors.forename: Soumaya
authors.initials: S
authors.lastname: Ghodbane
authors.forename: Salem
authors.initials: S
authors.lastname: Amara
authors.forename: Josiane
authors.initials: J
authors.lastname: Arnaud
authors.forename: Catherine
authors.initials: C
authors.lastname: Garrel
authors.forename: Henri
authors.initials: H
authors.lastname: Faure
authors.forename: Alain
authors.initials: A
authors.lastname: Favier
authors.forename: Mohsen
authors.initials: M
authors.lastname: Sakly
authors.forename: Hafedh
authors.initials: H
authors.lastname: Abdelmelek
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004574:Electromagnetic Fields / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D064586:Selenic Acid; D018036:Selenium Compounds / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances; D014801:Vitamin A / Q000097:blood*; D024502:alpha-Tocopherol / Q000097:blood*
chemical_list: D000975:Antioxidants; D018036:Selenium Compounds; D017392:Thiobarbituric Acid Reactive Substances; D014801:Vitamin A; D024502:alpha-Tocopherol; D064586:Selenic Acid