title: [Effects of long-term therapy with angiotensin-converting enzyme inhibitor and carvedilol on the heart remodeling process after non-Q-wave myocardial infarction].
abstract: This 2-year comparative study of EchoCG data dynamics included 230 CHD patients after primary non-Q-wave myocardial infarction of whom 76 were treated with A CE inhibitor perindopril throughout the study period (group 1) and 72 with perindopril and carvedilol (non-selective alpha-1, beta-1,2 adrenergic receptor blocker) (group 2). The control group was comprised of 82 patients that could not use either medicine for a variety of reasons. These patients developed signs of post-infarction left ventricular remodeling (enhanced MS and LVMM index, left ventricular spherization, cavity enlargement, systolic and diastolic LF dysfunction). Combined therapy arrested the remodeling process within 12 months after onset, reduced systolic MS, and promoted the tendency toward restoration of the LV geometric shape, size, diastolic and systolic function.
authors.forename: R G
authors.initials: RG
authors.lastname: Bakaev
authors.forename: A V
authors.initials: AV
authors.lastname: Strutynskiĭ
authors.forename: A N
authors.initials: AN
authors.lastname: Kallaeva
authors.forename: A B
authors.initials: AB
authors.lastname: Glazunov
authors.forename: M A
authors.initials: MA
authors.lastname: Voronina
authors.forename: D A
authors.initials: DA
authors.lastname: Pekhtereva
authors.forename: N K
authors.initials: NK
authors.lastname: Moshkova
authors.forename: E A
authors.initials: EA
authors.lastname: Chudnovskaia
authors.forename: B M
authors.initials: BM
authors.lastname: Kochetkov
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D004359:Drug Therapy, Combination; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D020913:Perindopril / Q000627:therapeutic use; D011412:Propanolamines / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D020913:Perindopril