title: [Modifications of the glucose curves and gastric voiding of children with Dumping syndrome after laparoscopic Nissen surgery].
abstract: BACKGROUND
  There has been an important evolution of surgical treatment in recent years due to the progressive generalization of laparoscopic surgery. All of the available techniques can be done laparoscopically with similar results to those of open surgery. In 1978, Villet et al. described the Dumping syndrome (DS) as a frequent complication of Nissen fundoplication. DS is a group of signs and symptoms that appear shortly after surgery, including abdominal pain, paleness, sweating, diarrhea, nausea, even weight loss. These symptoms can be differentiated into early dumping that occurs between 30 to 60 minutes after eating and late dumping that occurs 92-240 minutes after the postprandial period.
  
  
  METHODS
  A total of 8 patients (3 boys and 5 girls) have been studied. Their ages ranged from 3 to 12 years (mean 9 years), and they were diagnosed of dumping syndrome after performing the laparoscopic Nissen-Rossetti. All underwent a gastric voiding study by scintigraphy after administration of a volume of milk adjusted to their weight labeled with 99Tc-DTPA and oral glucose overload test with 1.75 g/kg of glucose, determining the baseline glycemia and every 30 minutes post-intake, at 0, 30 and 90 minutes. Insulin was also measured to obtain the glucose/insulin ratio. This study was conducted for all patient diagnosed of dumping syndrome before and after laparoscopic Nissen-Rossetti surgery.
  
  
  RESULTS
  The following results were obtained: Glucose Curve: 1. Maximum glycemia. PreNissen. The mean of the maximum glycemia values before surgery was 133.9+/-32.11 mg/dl. Post-Nissen. Mean maximum glycemias after surgery was 208.5 +/- 45.07 mg/dl with a range of 147-276 mg/dl. These differences of maximum glycemia were clearly significant with a p <0.002. Minimum glycemia. The mean value of the minimum glycemias after the surgery, compared with the previous value, did not show significant differences: 62.6+/- 11.51 mg/dl versus 71.8 +/- 28.04 mg/dl. Glucose/insulin ratio. The hyperinsulinism values after the intervention studied by means of the glucose/insulin ratio were abnormal in 70.5% (defined as ratio under 3). The mean value was also characteristic of hyperinsulinism (2.3 +/- 1.62). The mean value of the coefficient prior to the surgery was 4.6 with a deviation of 3.04, the differences not being statistically significant with a p= 0.097. Measurement of gastric voiding: The T1/2 (decay) value in post-Nissen patients was significantly lower than in pre-Nissen patients. The postsurgical mean and standard deviation was 29.74 +/- 7.92 min, while in the presurgical group, the mean and standard deviation was 73.75 +/- 28.34 min with p< 0.011; statistically significant.
  
  
  CONCLUSIONS
  From the values obtained, we can state that a significant increase in maximum glycemia has been found in all children after surgery who were diagnosed of dumping syndrome and a significant decrease in the mean time of gastric voiding and therefore an increase in the acceleration of gastric voiding after the performance of the Nissen regarding the previous values. The dumping syndrome is a frequent side effect that we must keep in mind in patients who have been previously operated for anti-reflex surgery, the symptoms being greater in most of the transitory cases. Furthermore, it is important to keep in mind because it has an easy treatment that reverts the symptoms in a short time
authors.affiliation: Servicio de Cirugía Pediátrica, Infantil Hospital General Universitario de Alicante. oscarsanchezparis@me.com
authors.forename: O
authors.initials: O
authors.lastname: Sánchez Paris
authors.forename: O
authors.initials: O
authors.lastname: Manrique Moral
authors.forename: J
authors.initials: J
authors.lastname: Mira Navarro
authors.forename: J
authors.initials: J
authors.lastname: Verdú
authors.forename: A
authors.initials: A
authors.lastname: Encinas Goenechea
authors.forename: M E
authors.initials: ME
authors.lastname: Martin Hortigüela
authors.forename: F
authors.initials: F
authors.lastname: Clemente Yago
authors.forename: N
authors.initials: N
authors.lastname: Garramone Trinchieri
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004377:Dumping Syndrome / Q000097:blood* / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D018662:Fundoplication / Q000009:adverse effects* / Q000379:methods; D005746:Gastric Emptying; D006801:Humans; D010535:Laparoscopy; D008297:Male
chemical_list: D001786:Blood Glucose