title: [Study of nucleolar organizer regions in prostate cancer].
abstract: OBJECTIVE
  To compare the qualitative and quantitative AgNOR scores per nucleus of histological grades.
  
  
  METHODS
  Thirty-five needle biopsies from patients with prostate cancer (PC) aged 60 to 75 years were investigated. The morphologic parameters examined on histological specimens were: microscopic patterns, Gleason's histological grades (GLG), and AgNOR scores by automated image analyzer and quantitative AgNOR counts according to the classification, fine granules, large granules, and total granule counts.
  
  
  RESULTS
  Our data suggest a significant correlation between GLG, AgNOR scores, and the percentage of both AgNOR fine and large granules. In HPIN, AgNOR count was evidently higher (5.56) as compared to normal acinar epithelium, slightly exceeding the level found in well-differentiated carcinoma (5.3). In our cases, the highest AgNOR counts were found in poorly differentiated carcinomas (9.81). AgNOR density in ductal carcinomas (7.61) was close to that in moderately differentiated carcinomas (7.35).
  
  
  CONCLUSIONS
  This simple method may aid diagnostic judgement when interpreting needle biopsies of malignancy and act as a prognostic marker useful for identifying PC of low and high malignancy.
authors.affiliation: Spitalul clinic nr.2 C.I. Parhon Iaşi, Laboratorul de Anatomie patologică, Iaşi Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
authors.forename: Silvia-Lărămioara
authors.initials: SL
authors.lastname: Roznovan
authors.forename: Doina Lucia
authors.initials: DL
authors.lastname: Frâncu
authors.forename: Cornelia
authors.initials: C
authors.lastname: Amălinei
authors.forename: Doiniţa
authors.initials: D
authors.lastname: Rădulescu
mesh_terms: D000368:Aged; D000465:Algorithms; D034961:Antigens, Nuclear / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001707:Biopsy, Needle; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure*; D044584:Carcinoma, Ductal / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009697:Nucleolus Organizer Region / Q000737:chemistry* / Q000648:ultrastructure*; D011237:Predictive Value of Tests; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure*; D012680:Sensitivity and Specificity
chemical_list: D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; C051963:nucleolar organizer region associated proteins