title: [Preoperative analysis of platelet aggregability in carotid surgery].
abstract: To evaluate the relationship between preoperative analysis of platelet aggregability and perioperative complications, we analyzed 42 patients who underwent carotid endarterectomy or carotid artery stenting. The effect of antiplatelet drugs was tested by whole blood aggregometry. ADP (adenosine-diphosphoric acid) and collagen were used as agonists. According to platelet aggregability, patients were classified into 4 groups (class A: highly inhibited, class B: moderately inhibited, class C: normally inhibited, class D: non-inhibited). Seven (32%) of 22 patients were stratified as clopidogrel nonresponders, whereas four (10%) of 40 patients were aspirin nonresponders. Hemorrhagic complications were registered in four patients. All of them were classified as class A. Ischemic complications occurred in two patients, one was classified as class C, the other was class D. Preoperative analysis of platelet aggregability could be useful to reduce the risk of perioperative complications after carotid surgery.
authors.affiliation: Department of Neurosurgery, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Morofuji
authors.forename: Gohei
authors.initials: G
authors.lastname: So
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hiu
authors.forename: Junichi
authors.initials: J
authors.lastname: Kawakubo
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Kitagawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Morikawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Suyama
authors.forename: Izumi
authors.initials: I
authors.lastname: Nagata
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000008:administration & dosage; D002339:Carotid Arteries / Q000601:surgery*; D000077144:Clopidogrel; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D007511:Ischemia / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D059035:Perioperative Period; D010974:Platelet Aggregation / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control; D012189:Retrospective Studies; D015607:Stents; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin