title: Huntington's disease - clinical signs, symptoms, presymptomatic diagnosis, and diagnosis.
abstract: HD is a complex illness, with a broad clinical picture that begins years before clear motor onset and evolves over decades to a terminal state of extreme disability. It challenges the resources of families and communities and the skills of medical and ancillary health care providers. A broader understanding of the phenotypes, progression, and genetic basis of HD may elevate the standard of care for these deserving patients.
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA. Kathleen_M_Shannon@rush.edu
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Shannon
mesh_terms: D017668:Age of Onset; D003072:Cognition Disorders / Q000209:etiology; D003952:Diagnostic Imaging / Q000379:methods; D006233:Persons with Disabilities; D018450:Disease Progression; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000175:diagnosis* / Q000235:genetics / Q000266:history / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000235:genetics; D009482:Neurophysiology; D009687:Nuclear Proteins / Q000235:genetics; D011237:Predictive Value of Tests; D019680:Trinucleotide Repeat Expansion / Q000235:genetics
chemical_list: C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins