title: Activity-based profiling for drug discovery.
abstract: Activity-based protein profiling (ABPP) is emerging as a game-changing tool for drug discovery, target validation, and basic biology. In this issue, Chang et al. (2011) report the ABPP-facilitated discovery of JW480, a highly selective potent and orally bioavailable inhibitor of monoalkylglycerol ether hydrolase KIAA1363 that dramatically impairs in vivo growth of human prostate cancer cell lines.
authors.affiliation: Institute of Chemical Biology, Department of Chemistry, Imperial College London, South Kensington Campus, London SW72AZ, UK.
authors.forename: Remigiusz
authors.initials: R
authors.lastname: Serwa
authors.forename: Edward W
authors.initials: EW
authors.lastname: Tate