title: Effect of combination of preoperative ibuprofen/acetaminophen on the success of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis.
abstract: BACKGROUND
  The purpose of this prospective, randomized, double-blind, placebo-controlled study was to determine the effect of the administration of the combination of preoperative ibuprofen/acetaminophen on the success of the inferior alveolar nerve (IAN) block in patients with symptomatic irreversible pulpitis.
  
  
  METHODS
  One hundred endodontic emergency patients in moderate to severe pain diagnosed with irreversible pulpitis of a mandibular posterior tooth randomly received, in a double-blind manner, identical capsules of either a combination of 800 mg ibuprofen and 1000 mg acetaminophen or placebo 45 minutes before the administration of a conventional IAN block. Access was begun 15 minutes after completion of the IAN block, and all patients had profound lip numbness. Success was defined as no or mild pain (visual analog scale recordings) on access or initial instrumentation.
  
  
  CONCLUSIONS
  The success rate for the IAN block was 32% for the combination ibuprofen/acetaminophen group and 24% for the placebo, with no significant difference (P = .37) between the 2 groups. For mandibular posterior teeth, a combination dose of 800 mg ibuprofen and 1000 mg acetaminophen given 45 minutes before administration of the IAN block did not result in a statistically significant increase in anesthetic success in patients with symptomatic irreversible pulpitis.
authors.affiliation: The Ohio State University, Columbus, OH, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Simpson
authors.forename: Melissa
authors.initials: M
authors.lastname: Drum
authors.forename: John
authors.initials: J
authors.lastname: Nusstein
authors.forename: Al
authors.initials: A
authors.lastname: Reader
authors.forename: Mike
authors.initials: M
authors.lastname: Beck
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use*; D000779:Anesthetics, Local / Q000008:administration & dosage; D001641:Bicuspid / Q000187:drug effects; D002355:Carticaine / Q000008:administration & dosage; D003782:Dental Pulp / Q000187:drug effects; D003804:Dentin / Q000187:drug effects; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D008046:Lip / Q000294:innervation; D008297:Male; D008340:Mandibular Nerve / Q000187:drug effects*; D008963:Molar / Q000187:drug effects; D008964:Molar, Third / Q000187:drug effects; D009407:Nerve Block / Q000379:methods*; D010147:Pain Measurement; D010919:Placebos; D011292:Premedication; D011446:Prospective Studies; D011671:Pulpitis / Q000628:therapy*; D018915:Root Canal Preparation / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D000779:Anesthetics, Local; D004338:Drug Combinations; D010919:Placebos; D000082:Acetaminophen; D002355:Carticaine; D007052:Ibuprofen