title: Incidence of tympanic membrane perforation after intratympanic steroid treatment through myringotomy tubes.
abstract: Intratympanic (IT) steroids are often used to treat inner ear disorders such as sudden idiopathic sensorineural hearing loss, autoimmune inner ear disease, and Ménière disease. Administration of corticosteroids via IT injection, via application with a pledget to the round window, or via catheter has been used for this purpose. The frequency of adverse events related to the IT injection of steroids is low, with pain, short-lasting vertigo, otitis media, and tympanic perforations being the most common complications. However, the safety of IT steroid therapy has not yet been established in a randomized clinical trial. In this article, we discuss a group of 11 patients with sensorineural hearing loss who underwent myringotomy and tube placement for home-based dexamethasone instillation and subsequently developed the complication of tympanic membrane perforation. It appears that there is a significantly increased incidence of tympanic membrane perforations in this population.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Detroit Medical Center/Michigan State University, Detroit, MI, USA.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Rutt
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Hawkshaw
authors.forename: Robert T
authors.initials: RT
authors.lastname: Sataloff
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D003907:Dexamethasone / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects*; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D018058:Tympanic Membrane Perforation / Q000209:etiology*
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone