title: Effects of Phellinus linteus administration on serotonin synthesis in the brain and expression of monocarboxylate transporters in the muscle during exhaustive exercise in rats.
abstract: This study was conducted to determine the effects of Phellinus linteus (PL) on serotonin synthesis in the brain and on the expression of monocarboxylate transporters (MCTs) in muscles during exhaustive exercise in rats. In this study, 60 male Sprague-Dawley rats were divided into the following 6 groups: control; exercise; exercise and 50 mg/kg of PL treatment; exercise and 100 of mg/kg PL treatment; exercise and 200 mg/kg of PL treatment; and exercise and 100 mg/kg of caffeine treatment. Treatment with 200 mg/kg of PL led to a significant increase in the time to exhaustion in response to running on a treadmill and a significant decrease in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rats. MCT1 and MCT4 expression of the gastrocnemius muscles was also increased in response to treatment with 200 mg/kg of PL. The results of the present study demonstrated that the administration of PL increased endurance exercise performance through inhibition of serotonin production in the brain and increased the expression of MCT1 and MCT4 in muscles. These results suggest that PL exerts an ergogenic effect.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Seo
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Sung
authors.forename: Ki-Jeong
authors.initials: KJ
authors.lastname: Kim
authors.forename: Mal-Soon
authors.initials: MS
authors.lastname: Shin
authors.forename: Eun-Kyu
authors.initials: EK
authors.lastname: Lee
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002110:Caffeine / Q000494:pharmacology; D005080:Exercise Test; D008297:Male; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism*; D009043:Motor Activity; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D000084682:Phellinus; D010936:Plant Extracts; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000096:biosynthesis*; D027981:Symporters / Q000378:metabolism*; D000099233:Monocarboxylate Transport Protein 1
chemical_list: D002110:Caffeine; D027501:Monocarboxylic Acid Transporters; D009124:Muscle Proteins; D010936:Plant Extracts; D011134:Polysaccharides; D012701:Serotonin; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1; C526145:Phellinus linteus extract; C516342:Slc16a3 protein, rat