title: [Genetic effects of bystander factors from the blood sera of people irradiated as the result of the Chernobyl accident].
abstract: The purpose of this work was the analysis of the effects of bystander factors from blood sera of people affected by the Chernobyl accident on human keratinocyte cell culture (HPV-G cells). A new method was developed for evaluation of the bystander factor presence in vivo in blood of the people irradiated by the Chernobyl accident. Affected population groups included liquidators of the Chernobyl accident and people living and working in areas of the Gomel region contaminated by radionuclides. The analysis has shown that bystander factors persist in Chernobyl liquidator blood samples for more than 20 years since irradiation. The data suggest that blood sera contain bystander factors, which are able to induce micronuclei and decrease the metabolic activity of HPV-G cells.
authors.forename: P M
authors.initials: PM
authors.lastname: Morozik
authors.forename: I B
authors.initials: IB
authors.lastname: Mosse
authors.forename: S B
authors.initials: SB
authors.lastname: Mel'nov
authors.forename: M S
authors.initials: MS
authors.lastname: Morozik
authors.forename: K B
authors.initials: KB
authors.lastname: Seymour
authors.forename: C E
authors.initials: CE
authors.lastname: Mothersill
mesh_terms: D001685:Biological Factors / Q000097:blood / Q000494:pharmacology*; D024201:Bystander Effect / Q000235:genetics*; D016022:Case-Control Studies; D018929:Cell Culture Techniques; D002460:Cell Line; D047852:Chernobyl Nuclear Accident; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008543:Melanins / Q000494:pharmacology; D008550:Melatonin / Q000494:pharmacology; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects; D015162:Micronucleus Tests; D011837:Radiation-Protective Agents / Q000494:pharmacology; D044967:Serum / Q000737:chemistry / Q000528:radiation effects*; D014455:Ukraine
chemical_list: D001685:Biological Factors; D008543:Melanins; D011837:Radiation-Protective Agents; D008550:Melatonin