title: Second international workshop for glycosylation defects in muscular dystrophies, 11-12 November, 2010, Charlotte, USA.
abstract: The second International Workshop for Glycosylation Defects in Muscular Dystrophies took place on November 11 and 12, 2010 in Charlotte, North Carolina, USA. The meeting was hosted by the Carolinas Medical Center with financial support from the Carolinas Muscular Dystrophy Research Endowment at the Carolinas HealthCare Foundation, the Muscular Dystrophy Association and funds raised by the "Jeans, Genes & Geniuses" event organized by Jane and Luther Lockwood. Since conducting the first workshop in May 2008, significant progress has been made in a subset of muscular dystrophies associated with defects in alpha-dystroglycan (α-DG) glycosylation. New findings on α-DG glycosylation and creation of novel animal models have expanded our understanding of the disease mechanism. The 2010 workshop focused on the following topics; (i) functional glycosylation of α-DG; (ii) animal models; and (iii) novel experimental therapies. The workshop brought together a total of 22 internationally renowned scientists and clinicians from US, UK, Denmark and Japan with active research and expertise in these areas. Overall, the workshop provided a unique opportunity to discuss the significance of recent progress, facilitate international collaboration, and identify new approaches to treat the disease.
authors.affiliation: McColl-Lockwood Laboratory for Muscular Dystrophy Research, Neuromuscular/ALS Center, Carolinas Medical Center, Charlotte, NC, USA. yiumo.chan@carolinashealthcare.org
authors.forename: Yiumo M
authors.initials: YM
authors.lastname: Chan
authors.forename: Susan C
authors.initials: SC
authors.lastname: Brown
authors.forename: Qi
authors.initials: Q
authors.lastname: Lu
mesh_terms: D000818:Animals; D006031:Glycosylation; D006801:Humans; D009136:Muscular Dystrophies / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy