title: [Characteristics of arginine metabolism and nitric oxide synthesis in young people during adaptation to physical load in training and competition periods].
abstract: A survey of 29 trained and untrained youths in the age of 18-20 years was carried out. It is shown that the optimal level of adaptation of the body to prolonged and intensive physical activity is provided by multi-dominance nonoxidizing arginase metabolism and its oxidative metabolism by constitutively calcium dependent NO-synthase (eNOS and nNOS). Nonoxidizing arginase metabolism results in formation of several important low-molecular bioregulators and antioxidants (urea, polyamines, GABA). Significant reduction of functionality of the trained body at the end of the competitive period and consequently disadaptation correlates with Ca(2+)-independent NO synthesis which does not compensate the organism needs in NO.
authors.forename: N V
authors.initials: NV
authors.lastname: Bohdanovs'ka
authors.forename: A V
authors.initials: AV
authors.lastname: Kotsiuruba
authors.forename: M V
authors.initials: MV
authors.lastname: Malikov
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D001120:Arginine / Q000378:metabolism* / Q000502:physiology; D015317:Biogenic Polyamines / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D005082:Physical Exertion / Q000502:physiology*; D013177:Sports / Q000502:physiology*; D014508:Urea / Q000097:blood; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000097:blood
chemical_list: D015317:Biogenic Polyamines; D015415:Biomarkers; D009569:Nitric Oxide; D005680:gamma-Aminobutyric Acid; D014508:Urea; D001120:Arginine