title: Valproate-induced Fanconi syndrome in a 27-year-old woman.
abstract: Valproate-induced Fanconi Syndrome (VFS) is a rare complication of this therapy that has been previously described only in children with epilepsy. We report the first known case of an adult with VFS. Metabolic derangements lead patients to present with fatigue, confusion, weakness, and even bone fractures. Identification and discontinuation of the offending agent is the treatment of choice and helps confirm the diagnosis. This case highlights the importance of surveillance for metabolic derangements among patients on long term therapy with this commonly prescribed medication.
authors.affiliation: Department of Internal Medicine, Primary Care Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Sandeep M
authors.initials: SM
authors.lastname: Patel
authors.forename: Jonathan
authors.initials: J
authors.lastname: Graff-Radford
authors.forename: Mark L
authors.initials: ML
authors.lastname: Wieland
mesh_terms: D000328:Adult; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D014635:Valproic Acid