title: Reversible cerebral vasoconstriction phenomena following indomethacin administration.
abstract: We report a case of reversible cerebral vasoconstriction, possibly secondary to the use of indomethacin to relieve pain during a migraine with aura attack. Non-steroidal anti-inflammatory drugs are not reported among substances precipitating secondary forms of reversible cerebral vasoconstriction. A transcranial Doppler sonography study, performed during the phase with headache and the other neurological deficits, suggested the presence of distal cerebral vasospasm, which normalized when all symptoms regressed completely (<24 hours). We speculated that indomethacin might represent the trigger factor of these particular phenomena, by acting either directly on distal cerebral vessels, or under certain predisposing conditions, such as migraine with aura attacks.
authors.affiliation: Department of Neurology, Headache Center, University of Parma, Parma, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Lambru
authors.forename: Gian Camillo
authors.initials: GC
authors.lastname: Manzoni
authors.forename: Paola
authors.initials: P
authors.lastname: Torelli
authors.forename: Ilaria
authors.initials: I
authors.lastname: Grisendi
authors.forename: Carla
authors.initials: C
authors.lastname: Zanferrari
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation / Q000187:drug effects; D050171:Dyslipidemias / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007213:Indomethacin / Q000009:adverse effects*; D020325:Migraine with Aura / Q000188:drug therapy*; D017585:Ultrasonography, Doppler, Transcranial; D020301:Vasospasm, Intracranial / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007213:Indomethacin