title: Cytotoxic cardenolide glycosides from the seeds of Antiaris toxicaria.
abstract: Bioassay-guided fractionation of the ethanolic extract from the seeds of Antiaris toxicaria led to the isolation of three new cardiac glycosides named toxicarioside J, toxicarioside K, and toxicarioside L, together with a known glucostrophalloside. The structures of the new compounds were elucidated by spectroscopic methods including HRESIMS, UV, IR, and 1D, 2D NMR techniques. The cytotoxic activities of these cardiac glycosides against human gastric (SGC-7901) and human hepatoma (SMMC-7721) cell lines were evaluated, and all of them exhibited significant cytotoxicity.
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, P. R. China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Dong
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Zeng
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Zuo
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Li
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D031621:Antiaris / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001681:Biological Assay; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002301:Cardiac Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008518:Medicine, East Asian Traditional; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D012639:Seeds / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D002301:Cardiac Glycosides; D010936:Plant Extracts; C587072:toxicarioside J; C587073:toxicarioside K; C587074:toxicarioside L