title: Risk factors for post-transplant lymphoproliferative disease in patients with cystic fibrosis.
abstract: The objective of this study was to retrospectively analyze risk factors associated with post-transplant lymphoproliferative disease (PTLD) in a cohort of 112 lung transplant recipients with cystic fibrosis (CF). Prior to transplantation, patients were tested for Epstein-Barr virus (EBV), human herpesvirus (HHV types 1, 2, 3, 6, and 8), herpes zoster virus, and cytomegalovirus (CMV) serologies. PTLD diagnosis was established based on increased EBV viral charge plus clinical/radiographic findings and confirmed by biopsy. Negative EBV and HHV serologies at the time of lung transplantation (LTx) were significant risk factors associated with development of PTLD in patients with CF in the univariate logistic regression analysis (p < 0.05) and also in the multivariate analysis (odds ratio of 77.5 and 12.5, respectively). CMV serology, CMV mismatch, acute rejection in the first three months following LTx, HLA-A3 antigen expression, and female gender did not affect PTLD. Our study confirmed the presence of a strong association between negative EBV serology at the time of LTx and PTLD and suggested an independent effect of negative HHV serology on PTLD.
authors.affiliation: Pôle Cardio-Thoracique Département d'Anesthésie-Réanimation, Hôpital Européen Georges Pompidou, Paris, France. mauriciosaueressig@gmail.com
authors.forename: Maurício G
authors.initials: MG
authors.lastname: Saueressig
authors.forename: Veronique
authors.initials: V
authors.lastname: Boussaud
authors.forename: Catherine
authors.initials: C
authors.lastname: Amrein
authors.forename: Romain
authors.initials: R
authors.lastname: Guillemain
authors.forename: Jihane
authors.initials: J
authors.lastname: Souilamas
authors.forename: Redha
authors.initials: R
authors.lastname: Souilamas
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000150:complications* / Q000628:therapy; D004279:DNA, Viral / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004279:DNA, Viral