title: Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis.
abstract: An impaired vitamin D (vit-D) processing by immune cells of relapsing remitting multiple sclerosis (RRMS) patients may increase their vulnerability for a poor vit-D status. We assessed with qPCR the expression of vit-D related genes in PBMC and CD4+ T-cells. Gene expression profiles of vit-D receptor (VDR), CYP27B1 and CYP24A1 did not differ between RRMS patients and healthy controls. Interestingly, more VDR expression in PBMC correlated with less circulating IFN-γ+ CD4+ T-cells. Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4+ T-cell compartment.
authors.affiliation: School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands. smolders@gmail.com
authors.forename: Joost
authors.initials: J
authors.lastname: Smolders
authors.forename: Mariëlle
authors.initials: M
authors.lastname: Thewissen
authors.forename: Ruud
authors.initials: R
authors.lastname: Theunissen
authors.forename: Evelyn
authors.initials: E
authors.lastname: Peelen
authors.forename: Stephanie
authors.initials: S
authors.lastname: Knippenberg
authors.forename: Paul
authors.initials: P
authors.lastname: Menheere
authors.forename: Jan Willem
authors.initials: JW
authors.lastname: Cohen Tervaert
authors.forename: Raymond
authors.initials: R
authors.lastname: Hupperts
authors.forename: Jan
authors.initials: J
authors.lastname: Damoiseaux
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000473:pathology*; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D018167:Receptors, Calcitriol / Q000096:biosynthesis* / Q000235:genetics; D014807:Vitamin D / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D