title: Diffusion-weighted imaging of hyperacute cerebral hypoglycemia.
abstract: OBJECTIVE
  Cerebral hypoglycemia can result in reversible metabolic brain insults and can be associated with impaired diffusion disturbances. Our aim was to evaluate possible changes in DWI of the human brain during hyperacute short-term severe hypoglycemia.
  
  
  METHODS
  Ten individuals scheduled for a clinical IST were examined with DWI while the test was performed. Venous blood glucose was continuously measured, and sequential DWI sequences were performed without interruption. Hypoglycemia was terminated with intravenous glucose administration when glucose levels were at ≤2.0 mmol/L.
  
  
  RESULTS
  Blood glucose levels were lowered to a mean nadir of 1.75 ± 0.38 mmol/L. No alterations of cerebral diffusion could be observed in any individuals on DWI.
  
  
  CONCLUSIONS
  Hyperacute short-term severe hypoglycemia does not induce visible changes in DWI of the human brain.
authors.affiliation: Institute of Diagnostic and Interventional Radiology, University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. peter.schmidt@med.uni-jena.de
authors.forename: P
authors.initials: P
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Böttcher
authors.forename: A
authors.initials: A
authors.lastname: Ragoschke-Schumm
authors.forename: H J
authors.initials: HJ
authors.lastname: Mentzel
authors.forename: G
authors.initials: G
authors.lastname: Wolf
authors.forename: U A
authors.initials: UA
authors.lastname: Müller
authors.forename: W A
authors.initials: WA
authors.lastname: Kaiser
authors.forename: T E
authors.initials: TE
authors.lastname: Mayer
authors.forename: A
authors.initials: A
authors.lastname: Saemann
mesh_terms: D000208:Acute Disease; D000309:Adrenal Insufficiency / Q000150:complications / Q000378:metabolism; D000328:Adult; D001786:Blood Glucose / Q000187:drug effects; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology*; D007004:Hypoglycemic Agents / Q000009:adverse effects; D007328:Insulin / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013997:Time Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose