title: Invadopodia: RhoC runs rings around cofilin.
abstract: Tumor cell invadopodia mediate degradation of matrix barriers. A new study now demonstrates that a ring of active RhoC focuses invadopodial protrusion and degradation by regulating cofilin activity.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. stacey.macgrath@yale.edu
authors.forename: Stacey M
authors.initials: SM
authors.lastname: MacGrath
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Koleske
mesh_terms: D051339:Actin Depolymerizing Factors / Q000378:metabolism; D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D002465:Cell Movement; D022081:Cell Surface Extensions / Q000378:metabolism; D005260:Female; D006801:Humans; D010766:Phosphorylation; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D051339:Actin Depolymerizing Factors; D020741:rho GTP-Binding Proteins