title: High b-value diffusion-weighted MRI in differentiation between benign and malignant polypoid gallbladder lesions.
abstract: BACKGROUND
  Several studies have reported the effectiveness of high b-value diffusion-weighted MR imaging (DWI) in the abdominal region, and have found that various malignant tumors may show high signal intensity on DWI, reflecting their high cellularity and/or their long relaxation time. The value of ADC measurement has also been documented for the diagnosis of several abdominal malignancies.
  
  
  OBJECTIVE
  To retrospectively evaluate the usefulness of high b-value DWI in differentiating between benign and malignant polypoid gallbladder lesions.
  
  
  METHODS
  The study population consisted of 10 benign (three hyperplastic polyps and seven adenomas) and 13 malignant (all adenocarcinomas) polypoid gallbladder lesions. DWI was evaluated by two observers. Qualitatively, the signal intensity of the lesions on DWI was visually evaluated and categorized as iso, high, or very high. Quantitatively, the ADC values of the lesions were measured from ADC maps. Statistical analysis was performed using a two-tailed Fisher's exact test and the Mann-Whitney test, respectively.
  
  
  RESULTS
  Qualitative analysis revealed a statistical difference (P = 0.0041). Six of 10 benign lesions were categorized as iso, and the remaining four were categorized as high. In the 13 malignant lesions, one was categorized as iso, five as high, and seven as very high. The ADC values of the malignant lesions (1.34 ± 0.50 × 10(-3) mm(2)/sec) were significantly lower than those of the benign lesions (2.26 ± 0.44 × 10(-3) mm(2)/sec) (P = 0.00016).
  
  
  CONCLUSIONS
  High b-value DWI may be useful for differentiating between benign and malignant polypoid gallbladder lesions by the visual assessment of DWI and ADC measurement.
authors.affiliation: Department of Radiology, Faculty of Medicine, Saga University, Nabeshima, Japan. irie@cc.saga-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Irie
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kamochi
authors.forename: Junichi
authors.initials: J
authors.lastname: Nojiri
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Egashira
authors.forename: Kohei
authors.initials: K
authors.lastname: Sasaguri
authors.forename: Sho
authors.initials: S
authors.lastname: Kudo
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000236:Adenoma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005706:Gallbladder Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000473:pathology* / Q000601:surgery; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018709:Statistics, Nonparametric