title: Role of appropriate surgery in survival of patients with epithelial ovarian cancer.
abstract: OBJECTIVE
  Management of epithelial ovarian cancer (EOC) patients is largely based on appropriate surgery. The principle treatment of early stage is competence of surgical staging surgery and surgical management of all patients with advance EOC is approach in a similar manner with cytoreduction surgery. We decided to evaluate the impact of appropriate surgery as a scale on 2 and 5-year survival in EOC patients.
  
  
  METHODS
  In a descriptive analytic study a total 186 patients were divided into 62 with early stage of EOC equivocal FIGO stage I and 124 with advanced disease at Vali-e-Asr Hospital affiliated with Tehran University of Medical Science, Iran, from 1998 to 2008. Two and 5-year disease free survival (DFS) and overall survival rates were determined and compared between the two groups using chi-squared test' Kaplan Meier and Cox regression.
  
  
  RESULTS
  Five-year DFS in patients with early stage of disease was 85% for the surgical staging group and 38% for non-surgical staging group (P = 0.037). Two-year DFS and overall survival did not differ between the groups. Also 5-year survival rates in subjects with surgical staging surgery were 42% and 40% for non staging group. For patients assigned to advanced disease group, 5-year DFS in subjects with cytoreductive surgery was 73% and the figure for the remainder was 58%. Five-year overall survival rate in cytoreductive surgery group was 43% in comparison to 38% in the second group.
  
  
  CONCLUSIONS
  Maximal effort for appropriate surgery appears to be a corner stone for optimal survival.
authors.affiliation: Gynecological Oncology, Tehran University of Medical Sciences, Tehran, Iran. yousefiz@mums.ac.ir
authors.forename: F
authors.initials: F
authors.lastname: Gaemmaghami
authors.forename: Z
authors.initials: Z
authors.lastname: Yousefi
authors.forename: M
authors.initials: M
authors.lastname: Gilani
authors.forename: A
authors.initials: A
authors.lastname: Mosavi
authors.forename: M
authors.initials: M
authors.lastname: Shariat
mesh_terms: D000077216:Carcinoma, Ovarian Epithelial; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis