title: Effect of bilateral subthalamic nucleus deep brain stimulation on postural adjustments during arm movement.
abstract: OBJECTIVE
  Although it is well known that postural adjustment (PA) is impaired in advanced Parkinson's disease (PD), the potentially compensatory effects of bilateral subthalamic nucleus deep brain stimulation (STN DBS) in this respect are less clear.
  
  
  METHODS
  While standing on a force platform and in the absence of antiparkinsonian medication, 10 patients performed voluntary, unilateral arm movements before surgery (the 'off stim' condition) and then afterwards (the 'on stim' condition). The patients' PAs were monitored by vertical torque (Tz) and compared with those recorded in control subjects.
  
  
  RESULTS
  Patients with STN DBS and control subjects showed similar values for PA amplitude, duration and latency.
  
  
  CONCLUSIONS
  STN stimulation may induce better postural control during the movement preparation and execution phases. Our results argue in favour of a positive effect of STN DBS on PA.
  
  
  CONCLUSIONS
  The PA amplitude (provided by Tz) may be a strong marker reflecting the clinical improvement seen in stimulated PD patients.
authors.affiliation: Department of Clinical Neurophysiology, Université Lille Nord de France, UDSL, Laboratoire Neurosciences Fonctionnelles et Pathologies, LNFP-FRE 3291 CNRS, F-59037 Lille cedex, France. severine.bleuse@chru-lille.fr
authors.forename: S
authors.initials: S
authors.lastname: Bleuse
authors.forename: A
authors.initials: A
authors.lastname: Delval
authors.forename: J L
authors.initials: JL
authors.lastname: Blatt
authors.forename: P
authors.initials: P
authors.lastname: Derambure
authors.forename: A
authors.initials: A
authors.lastname: Destée
authors.forename: L
authors.initials: L
authors.lastname: Defebvre
mesh_terms: D000368:Aged; D001132:Arm / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy; D011187:Posture / Q000502:physiology*; D020531:Subthalamic Nucleus / Q000502:physiology*