title: Does stage II colorectal cancer need to be redefined?
abstract: Detection of guanylyl cyclase C mRNA in lymph nodes of resected stage II colorectal cancer is highly correlated with the risk of tumor recurrence. If validated, these results could have significant implications for the selection of patients for adjuvant therapy in this disease.
authors.affiliation: Mayo Clinic, Rochester, Minnesota 55905, USA. grothey.axel@mayo.edu
authors.forename: Axel
authors.initials: A
authors.lastname: Grothey
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D006301:Health Services Needs and Demand; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008954:Models, Biological; D009367:Neoplasm Staging; D018579:Patient Selection; D011379:Prognosis; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled / Q000235:genetics / Q000378:metabolism; D018000:Receptors, Peptide / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018000:Receptors, Peptide; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled