title: Osteoconductivity of thermal-sprayed silver-containing hydroxyapatite coating in the rat tibia.
abstract: A silver-containing hydroxyapatite (Ag-HA) coating has been developed using thermal spraying technology. We evaluated the osteoconductivity of this coating on titanium (Ti) implants in rat tibiae in relation to bacterial infection in joint replacement. At 12 weeks, the mean affinity indices of bone formation of a Ti, an HA, a 3%Ag-HA and a 50%Ag-HA coating were 97.3%, 84.9%, 81.0% and 40.5%, respectively. The mean affinity indices of bone contact of these four coatings were 18.8%, 83.7%, 77.2% and 40.5%, respectively. The indices of bone formation and bone contact around the implant of the 3%Ag-HA coating were similar to those of the HA coating, and no significant differences were found between them (bone formation, p = 0.99; bone contact, p = 0.957). However, inhibition of bone formation was observed with the 50%Ag-HA coating. These results indicate that the 3%Ag-HA coating has low toxicity and good osteoconductivity, and that the effect of silver toxicity on osteoconductivity depends on the dose.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. yoneyuta@acc.saga-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Yonekura
authors.forename: H
authors.initials: H
authors.lastname: Miyamoto
authors.forename: T
authors.initials: T
authors.lastname: Shimazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Ando
authors.forename: I
authors.initials: I
authors.lastname: Noda
authors.forename: M
authors.initials: M
authors.lastname: Mawatari
authors.forename: T
authors.initials: T
authors.lastname: Hotokebuchi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D020099:Coated Materials, Biocompatible; D017886:Durapatite / Q000494:pharmacology*; D007595:Joint Prosthesis; D008297:Male; D010087:Oxides / Q000494:pharmacology*; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D012834:Silver / Q000097:blood; D018030:Silver Compounds / Q000494:pharmacology*; D013977:Tibia / Q000601:surgery; D014025:Titanium
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D010087:Oxides; D018030:Silver Compounds; D012834:Silver; C040225:disilver oxide; D017886:Durapatite; D014025:Titanium