title: A new triterpene saponin from Androsace integra.
abstract: A new triterpene saponin, androsacin (1), along with two known compounds, ardisiacrispin A (2) and saxifragifolin A (3), were isolated from the whole plants of Androsace integra. The chemical structure of the new compound was elucidated as 3β-O-{β-D-glucopyranosyl-(1→4)-O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→4)-[O-β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl}-16α-hydroxy-13β,28-epoxy-olean-30-al on the basis of spectral evidence. Ardisiacrispin A (2) was cytotoxic toward HepG2 cancer cell with the GI(50) value of 1.56μM.
authors.affiliation: Shanghai Jiao Tong University, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Dong
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
authors.forename: Dajian
authors.initials: D
authors.lastname: Yang
authors.forename: Lisheng
authors.initials: L
authors.lastname: Ding
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D029623:Primulaceae / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C568439:androsacin; C054708:ardisiacrispin A; D009828:Oleanolic Acid