title: Tumour suppressor function of protein tyrosine phosphatase receptor-T.
abstract: It has long been thought that PTPs (protein tyrosine phosphatases) normally function as tumour suppressors. Recent high-throughput mutational analysis identified loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes. PTPRT (protein tyrosine phosphatase receptor-T), a member of the family of type IIB receptor-like PTPs, is the most frequently mutated PTP among them. Consistent with the notion that PTPRT is a tumour suppressor, PTPRT knockout mice are hypersensitive to AOM (azoxymethane)-induced colon cancer. The present review focuses on the physiological and pathological functions of PTPRT as well as the cellular pathways regulated by this phosphatase.
authors.affiliation: Department of Genetics and Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Scott
authors.forename: Zhenghe
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000737:chemistry / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2 / Q000737:chemistry / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000502:physiology*
chemical_list: D025521:Tumor Suppressor Proteins; C516865:PTPRT protein, human; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2