title: Chronic allograft dysfunction.
abstract: Chronic, progressive, and irreversible loss of lung function is the major medium-term and long-term complication after lung transplantation and the leading cause of death. Over the past decade, progress has been made in understanding the pathogenesis of bronchiolitis obliterans. Alloimmune factors and nonalloimmune factors may contribute to its development. Understanding the precise mechanism of each type of chronic allograft dysfunction may open up the field for new preventive and therapeutic interventions. This article reviews major new insights into the clinical aspects, pathophysiology, risk factors, diagnosis, and management of chronic allograft dysfunction after lung transplantation.
authors.affiliation: Department of Chest Medicine, Erasme University Hospital, Université Libre de Bruxelles, 808 Route de Lennik, B-1070 Brussels, Belgium. christiane.knoop@erasme.ulb.ac.be
authors.forename: Christiane
authors.initials: C
authors.lastname: Knoop
authors.forename: Marc
authors.initials: M
authors.lastname: Estenne
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001989:Bronchiolitis Obliterans / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D002908:Chronic Disease; D006084:Graft Rejection / Q000150:complications / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016040:Lung Transplantation / Q000276:immunology; D015182:Lymphatic Irradiation; D018942:Macrolides / Q000627:therapeutic use; D009504:Neutrophils / Q000276:immunology; D017893:Photopheresis; D011183:Postoperative Complications / Q000175:diagnosis / Q000628:therapy; D012086:Reoperation; D012129:Respiratory Function Tests
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D018942:Macrolides