title: A validation study of the Chinese wearing off questionnaire 9-symptom for Parkinson's disease.
abstract: OBJECTIVE
  Development of wearing off (WO) often goes unnoticed for both patients with Parkinson's disease (PD) and physicians due to the complexity of this phenomenon. A brief 9-symptom WO questionnaire (WOQ-9) was recently found to be highly sensitive in its detection. We aimed to validate a Chinese version WOQ-9 (CWOQ-9) among Chinese patients with PD.
  
  
  METHODS
  We recruited 101 literate Chinese PD patients among 4 different neurology or movement disorders clinics in Hong Kong to participate in this study by completing the CWOQ-9. Clinical judgment by the specialists was considered the gold standard for diagnosing WO.
  
  
  RESULTS
  The mean age (±SD) of the patients was 61 (±9) years and 35 (34.7%) of them were female. The disease duration was 7.4 (±5.4) years and 69 (68.3%) of them were diagnosed clinically to have WO by the specialists. The positive and negative predictive values, sensitivity and specificity of CWOQ-9 were 86%, 71%, 87%, and 69% respectively. The area under curve (AUC) was 0.78 (p<0.001).
  
  
  CONCLUSIONS
  This simple patient questionnaire is a valid tool for the detection of WO among Chinese PD patients.
authors.affiliation: Department of Medicine and Therapeutics, Prince of Wales Hospital, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.
authors.forename: A
authors.initials: A
authors.lastname: Chan
authors.forename: Y F
authors.initials: YF
authors.lastname: Cheung
authors.forename: M Au
authors.initials: MA
authors.lastname: Yeung
authors.forename: J
authors.initials: J
authors.lastname: Yeung
authors.forename: T H
authors.initials: TH
authors.lastname: Chung
authors.forename: K L
authors.initials: KL
authors.lastname: Tsang
authors.forename: J
authors.initials: J
authors.lastname: Chan
authors.forename: C
authors.initials: C
authors.lastname: Lau
authors.forename: P
authors.initials: P
authors.lastname: Kwan
authors.forename: Sheng-Han
authors.initials: SH
authors.lastname: Kuo
authors.forename: V
authors.initials: V
authors.lastname: Mok
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D044466:Asian People; D005260:Female; D006723:Hong Kong; D006801:Humans; D007802:Language; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy*; D010865:Pilot Projects; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa