title: Localized amyloidosis of the breast: a case series.
abstract: We report on the clinical presentation and histopathology of a series of seven patients with localized amyloidosis of the breast. These patients were diagnosed by biopsy performed to rule out malignancy because of calcifications seen by mammography, and represented 0.5% of patients referred to the Amyloid Treatment and Research Program at Boston University Medical Campus in an 18-year period. The patients ranged in age from 35 to 75, median 63 years. None of these seven patients had evidence of a systemic plasma cell dyscrasia or amyloidosis in other organs, nor did systemic disease develop with a median follow-up of 6 years. Thus, other than excisional biopsy to exclude malignancy, no systemic therapy is indicated for this disorder.
authors.affiliation: Section of Hematology and Oncology, Department of Medicine, Boston Medical Center, MA, USA.
authors.forename: Marjory
authors.initials: M
authors.lastname: Charlot
authors.forename: David C
authors.initials: DC
authors.lastname: Seldin
authors.forename: Carl
authors.initials: C
authors.lastname: O'hara
authors.forename: Martha
authors.initials: M
authors.lastname: Skinner
authors.forename: Vaishali
authors.initials: V
authors.lastname: Sanchorawala
mesh_terms: D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D001706:Biopsy; D001900:Boston; D001940:Breast / Q000473:pathology* / Q000601:surgery; D002114:Calcinosis; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged