title: Chemical constituents from endophytic fungus Fusarium oxysporum.
abstract: A new oxysporidinone analogue (1) and a new 3-hydroxyl-2-piperidinone derivative (2), along with the known compounds (-)-4,6'-anhydrooxysporidinone (3), (+)-fusarinolic acid (4), gibepyrone D (5), beauvercin (6),cerevisterol (7), fusaruside (8), and (2S,2'R,3R,3'E,4E,8E)-1-O-D-glucopyranosyl-2-N-(2'-hydroxy-3'-octadecenoyl)-3-hydroxy-9-methyl-4,8-sphingadienine (9) were isolated from Fusarium oxysporum. Compounds 1-9 were evaluated for cytotoxicity using the MTT method against cancer cell lines, PC-3, PANC-1, and A549. Beauvericin showed cytotoxicity against PC-3, PANC-1, and A549 with IC(50) value of 49.5 ± 3.8, 47.2 ± 2.9, and 10.4 ± 1.6μM, respectively. Beauvericin also exhibited anti-bacterial activity towards methicillin-resistant Staphylococcus aureus (MIC=3.125 μg/mL) and Bacillus subtilis (MIC=3.125 μg/mL).
authors.affiliation: School of Life Science, University of Science and Technology of China, PR China.
authors.forename: Quan-Xin
authors.initials: QX
authors.lastname: Wang
authors.forename: Sai-Fei
authors.initials: SF
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Huan-Qin
authors.initials: HQ
authors.lastname: Dai
authors.forename: Li
authors.initials: L
authors.lastname: Bao
authors.forename: Rong
authors.initials: R
authors.lastname: Ding
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Zhang
authors.forename: Hua-An
authors.initials: HA
authors.lastname: Wen
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D005670:Fusarium / Q000737:chemistry*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010881:Piperidones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011728:Pyridones / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D010881:Piperidones; D011728:Pyridones; C104552:oxysporidinone