title: Central 10-degree visual field change following trabeculectomy in advanced open-angle glaucoma.
abstract: OBJECTIVE
  To prospectively examine changes in the central visual field (VF) in patients with advanced open-angle glaucoma (OAG) with advanced late stage after trabeculectomy for 12 months.
  
  
  METHODS
  Prospective interventional case series.
  
  
  METHODS
  In all, 27 eyes of 27 OAG patients at a single center with a best-corrected visual acuity (BCVA) of ≥40/200 and a mean total deviation of test locations of the 10-2 program of the Humphrey VF analyzer of ≤-20 dB preoperatively were enrolled. Intraocular pressure (IOP), VF parameters of the 10-2 program, and BCVA were examined for 12 months after trabeculectomy with mitomycin C. Slopes of VF parameters and their correlation with presumed risk factors were studied.
  
  
  RESULTS
  IOP decreased from 19.7±5.8 to 9.7±2.6 mm Hg (P<0.001) over postoperative 1 year. The slopes of all VF parameters did not significantly differ from zero (P>0.33), and none of the presumed factors significantly correlated with the slopes of those parameters (P>0.14). There were two eyes (7%) and one eye (4%) with ≥2 lines of deterioration in BCVA (decimal fraction) at 1 and 12 months, respectively, after surgery with no apparent causes.
  
  
  CONCLUSIONS
  Trabeculectomy resulted in little change in the central 10-degree VF, but significant decrease in BCVA without apparent causes might occur approximately 5% of the cases.
authors.affiliation: Saitama Red Cross Hospital, Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fujishiro
authors.forename: C
authors.initials: C
authors.lastname: Mayama
authors.forename: M
authors.initials: M
authors.lastname: Aihara
authors.forename: A
authors.initials: A
authors.lastname: Tomidokoro
authors.forename: M
authors.initials: M
authors.lastname: Araie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D011446:Prospective Studies; D012307:Risk Factors; D014130:Trabeculectomy / Q000379:methods; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields / Q000502:physiology*
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin