title: Relevance of mast cell-nerve interactions in intestinal nociception.
abstract: Cross-talk between the immune- and nervous-system is considered an important biological process in health and disease. Because mast cells are often strategically placed between nerves and surrounding (immune)-cells they may function as important intermediate cells. This review summarizes the current knowledge on bidirectional interaction between mast cells and nerves and its possible relevance in (inflammation-induced) increased nociception. Our main focus is on mast cell mediators involved in sensitization of TRP channels, thereby contributing to nociception, as well as neuron-released neuropeptides and their effects on mast cell activation. Furthermore we discuss mechanisms involved in physical mast cell-nerve interactions. This article is part of a Special Issue entitled: Mast cells in inflammation.
authors.affiliation: Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands. s.a.vanDiest@AMC.UVA.NL
authors.forename: Sophie A
authors.initials: SA
authors.lastname: van Diest
authors.forename: Oana I
authors.initials: OI
authors.lastname: Stanisor
authors.forename: Guy E
authors.initials: GE
authors.lastname: Boeckxstaens
authors.forename: Wouter J
authors.initials: WJ
authors.lastname: de Jonge
authors.forename: René M
authors.initials: RM
authors.lastname: van den Wijngaard
mesh_terms: D000818:Animals; D002450:Cell Communication; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D007422:Intestines / Q000294:innervation / Q000473:pathology / Q000503:physiopathology*; D008407:Mast Cells / Q000378:metabolism*; D015213:Neuroimmunomodulation; D009475:Neurons, Afferent / Q000378:metabolism; D059225:Nociception; D059226:Nociceptive Pain / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D018836:Inflammation Mediators