title: Cutaneous MCTs: associations with spay/neuter status, breed, body size, and phylogenetic cluster.
abstract: Certain breeds are known to be overrepresented among mast cell tumor (MCT) patients, but other risk factors have not been evaluated. This study presents results from a case-control study of 252 dogs with grade 2 or grade 3 cutaneous MCT. Increased risk for MCT development was found in spayed females (adjusted odds ratio [OR], 4.11), boxers (adjusted OR, 6.09), Labrador retrievers (adjusted OR, 3.95), pugs (adjusted OR, 3.17), golden retrievers (adjusted OR, 2.12), the mastiff and terrier phylogenetic cluster (adjusted OR, 3.19), and breeds classified as large (adjusted OR, 2.10) or giant (adjusted OR, 5.44). Additional studies are needed to evaluate the role of these and other potential risk factors in MCT development.
authors.affiliation: Department of Internal Medicine, Animal Medical Center, New York, NY, USA. carrie.white@amcny.org
authors.forename: Carrie R
authors.initials: CR
authors.lastname: White
authors.forename: Ann E
authors.initials: AE
authors.lastname: Hohenhaus
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kelsey
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Procter-Gray
mesh_terms: D000818:Animals; D049628:Body Size / Q000502:physiology; D001947:Breeding; D016022:Case-Control Studies; D002369:Castration / Q000009:adverse effects / Q000662:veterinary*; D016001:Confidence Intervals; D004283:Dog Diseases / Q000453:epidemiology*; D004285:Dogs; D005260:Female; D008297:Male; D012515:Mast-Cell Sarcoma / Q000453:epidemiology / Q000662:veterinary*; D009367:Neoplasm Staging / Q000662:veterinary; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000662:veterinary*; D013045:Species Specificity