title: Direct arylation of heteroaromatic compounds with congested, functionalised aryl bromides at low palladium/triphosphane catalyst loading.
abstract: A new ferrocenyl triphosphane ligand associated to palladium was found to be an efficient catalyst for the direct coupling of highly congested, functionalised aryl bromides with a variety of heteroarenes. These coupling reactions can generally be performed by using a low-loading (0.1-0.5 mol%) of the catalyst. The present protocol tolerates important and useful functional groups, which allows for further elaboration into more sophisticated heterocyclic molecules. The straightforward arylation of heteroaromatic compounds with congested ortho-substituted aryl bromides may permit further convergent syntheses of diverse ligands, biologically active molecules and molecular materials in only a few steps.
authors.affiliation: UMR-CNRS 6226, équipe Catalyse et Organométalliques, Université de Rennes I, Campus de Beaulieu, 35042 Rennes, France.
authors.forename: David
authors.initials: D
authors.lastname: Roy
authors.forename: Sophal
authors.initials: S
authors.lastname: Mom
authors.forename: Dominique
authors.initials: D
authors.lastname: Lucas
authors.forename: Hélène
authors.initials: H
authors.lastname: Cattey
authors.forename: Jean-Cyrille
authors.initials: JC
authors.lastname: Hierso
authors.forename: Henri
authors.initials: H
authors.lastname: Doucet