title: Significant association of serum uric acid levels with SLC2A9 rs11722228 among a Japanese population.
abstract: Genome-wide association studies identified that SLC2A9 (GLUT9) gene polymorphisms were associated with serum uric acid (SUA) levels. Among the Japanese, a C/T polymorphism in intron 8 (rs11722228) was reported to be highly significant, though the function and strength of association were unknown. This study aimed to confirm the association, estimating the means of SUA according to the genotype, as well as OR of the genotype. Subjects were 5024 health checkup examinees (3413 males and 1611 females) aged 35 to 69 years with creatinine <2.0 mg/dL. Since SLC22A12 258X allele and ABCG2 126X allele are known to influence SUA levels strongly, the subjects with SLC22A12 258WW and ABCG2 126QQ (3082 males and 1453 females, in total 4535 subjects) were selected. The genotype frequency of SLC2A9 rs11722228 was 2184 for CC, 1947 for CT, and 404 for TT, being in Hardy-Weinberg equilibrium (p=0.312). Mean SUA was 6.10 mg/dL for CC, 6.25 mg/dL for CT, and 6.45 mg/dL for TT among males (p=1.5E-6), and 4.34 mg/dL, 4.59 mg/dL, and 4.87 mg/dL among females (p=4.6E-11), respectively. Males with SUA less than 5.0 mg/dL were 14.7% for CC, 10.6% for CT, and 7.8% for TT (p=2.3E-4), and females with SUA less than 4.0 mg/dL were 34.1%, 25.5%, and 15.4% (p=3.7E-6), respectively. This study was the first report to estimate the impact of SLC2A9 rs11722228 on SUA levels. Since the allele frequency of rs11722228 is similar among different ethnic groups, the impact remains to be examined in other ethnic groups.
authors.affiliation: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. nhamajim@med.nagoya-u.ac.jp
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamajima
authors.forename: Rieko
authors.initials: R
authors.lastname: Okada
authors.forename: Sayo
authors.initials: S
authors.lastname: Kawai
authors.forename: Asahi
authors.initials: A
authors.lastname: Hishida
authors.forename: Emi
authors.initials: E
authors.lastname: Morita
authors.forename: Guang
authors.initials: G
authors.lastname: Yin
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Matsuo
authors.forename: Hiroki
authors.initials: H
authors.lastname: Inoue
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Takada
authors.forename: Yatami
authors.initials: Y
authors.lastname: Asai
authors.forename: Atsuyoshi
authors.initials: A
authors.lastname: Mori
authors.forename: Mariko
authors.initials: M
authors.lastname: Naito
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D003404:Creatinine / Q000097:blood; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics*; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014527:Uric Acid / Q000097:blood*
chemical_list: D051246:Glucose Transport Proteins, Facilitative; C411811:SLC2A9 protein, human; D014527:Uric Acid; D003404:Creatinine