title: [Fibrillary nonamyloid glomerulonephritis: a rare etiology of nephrotic syndrome].
abstract: The fibrillary nonamyloïd glomerulonephritis is a glomerulopathy with fibrillar, nonamyloid deposits of predominantly polyclonal immunoglobulin G. It is an idiopathic glomerulopathy responsible for heavy proteinuria, generally in the nephrotic range, and renal failure up to end stage in 40 % of the cases after five years. The histologic pattern is variable, correlating with renal prognosis. The Congo red-negativity of the deposits and the size of the fibrils on electron microscopy make the differential diagnosis with amyloid deposits. There is no specific efficient therapy. Recurrence in the transplant is frequent, but with better renal prognosis.
authors.affiliation: Service de néphrologie du CHU de Liège, université de Liège, domaine universitaire du Sart-Tilman, B35, 4000 Liège, Belgique. sgrosch@chu.ulg.ac.be
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Grosch
authors.forename: Lionel
authors.initials: L
authors.lastname: Van Overmeire
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Krzesinski
authors.forename: Christophe
authors.initials: C
authors.lastname: Bovy
mesh_terms: D004396:Coloring Agents; D003176:Complement C3 / Q000032:analysis; D003224:Congo Red; D003937:Diagnosis, Differential; D004487:Edema / Q000209:etiology; D005260:Female; D005464:Fluorobenzenes / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000737:chemistry / Q000648:ultrastructure; D019808:Losartan / Q000627:therapeutic use; D008854:Microscopy, Electron; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000627:therapeutic use
chemical_list: D004396:Coloring Agents; D003176:Complement C3; D005464:Fluorobenzenes; D007074:Immunoglobulin G; D011743:Pyrimidines; D013449:Sulfonamides; D003224:Congo Red; D000068718:Rosuvastatin Calcium; D011239:Prednisolone; D019808:Losartan