title: Synthesis of novel chromene scaffolds for adenosine receptors.
abstract: A one-pot procedure was developed for the synthesis of novel 3-[amino(methoxy)methylene]-2-oxo-3,4-dihydro-2H-chromen-4-yl)-3-cyanoacetamides and chromeno[3,4-c]pyridine-1-carbonitriles from the reaction of 2-oxo-2H-chromene-3-carbonitriles and cyanoacetamides. These chromene derivatives were identified as new scaffolds for adenosine receptors and the hits 3a, 3c, 5a, and 5b were found.
authors.affiliation: Department of Chemistry, University of Minho, Campos de Gualtar, 4710-057, Braga, Portugal.
authors.forename: Marta
authors.initials: M
authors.lastname: Costa
authors.forename: Filipe
authors.initials: F
authors.lastname: Areias
authors.forename: Marian
authors.initials: M
authors.lastname: Castro
authors.forename: Jose
authors.initials: J
authors.lastname: Brea
authors.forename: María I
authors.initials: MI
authors.lastname: Loza
authors.forename: Fernanda
authors.initials: F
authors.lastname: Proença
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008968:Molecular Conformation; D018047:Receptors, Purinergic P1 / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D001578:Benzopyrans; D018047:Receptors, Purinergic P1