title: Low-density lipoprotein receptor-related protein 1 is associated with proliferation and invasiveness in Her-2/neu and triple-negative breast carcinomas.
abstract: Low-density lipoprotein receptor-related protein 1, a member of the low-density lipoprotein cholesterol receptor family, has been implicated in the progression of certain tumors; but it remains unclear whether it plays a role in infiltrating ductal breast carcinomas. We studied a series of 81 ductal breast tumors to determine the correlation of low-density lipoprotein receptor-related protein 1 overexpression with clinicopathologic and immunohistochemical characteristics associated with prognosis. Low-density lipoprotein receptor-related protein 1 overexpression was identified in 14% (11/81) of tumors and was correlated with a high nuclear grade (P = .043), high mitotic index (P = .006), and Ki-67 greater than 20% (P = .047). Furthermore, low-density lipoprotein receptor-related protein 1 expression was associated with aggressive carcinomas (triple-negative tumors [21%, 7/33] and Her-2/neu tumors [17%, 4/24]) but not with hormone-dependent carcinomas (0%, 0/24) (P = .040). There was no correlation between low-density lipoprotein receptor-related protein 1 expression and survival, but a trend was found between low-density lipoprotein receptor-related protein 1 overexpression and tumor recurrence. Low-density lipoprotein receptor-related protein 1 overexpression was related to proliferation and invasiveness in Her-2/neu and triple-negative breast carcinoma. Moreover, patients with low-density lipoprotein receptor-related protein 1-positive tumors had higher cholesterol levels (62.5%, 5/8) than those with low-density lipoprotein receptor-related protein 1-negative tumors (40%, 19/47). Nevertheless, the correlation between low-density lipoprotein receptor-related protein 1 and hypercholesterolemia was not statistically significant; but cholesterol levels were higher in patients with triple-negative breast carcinoma (60%, 15/25) and Her-2/neu carcinomas (40%, 6/15) than in luminal-A carcinomas (20%, 3/15) (P = .046). These findings suggest a relationship between hypercholesterolemia and aggressiveness of ductal breast carcinomas.
authors.affiliation: Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica (IIB) Sant Pau, Autonomous University of Barcelona, 08041 Barcelona, Spain. lcatasus@santpau.cat
authors.forename: Lluis
authors.initials: L
authors.lastname: Catasus
authors.forename: Alberto
authors.initials: A
authors.lastname: Gallardo
authors.forename: Vicenta
authors.initials: V
authors.lastname: Llorente-Cortes
authors.forename: Daniel
authors.initials: D
authors.lastname: Escuin
authors.forename: Josefina
authors.initials: J
authors.lastname: Muñoz
authors.forename: Ariadna
authors.initials: A
authors.lastname: Tibau
authors.forename: Gloria
authors.initials: G
authors.lastname: Peiro
authors.forename: Agusti
authors.initials: A
authors.lastname: Barnadas
authors.forename: Enrique
authors.initials: E
authors.lastname: Lerma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000097:blood / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000097:blood / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D002784:Cholesterol