title: Non-steroidal anti-inflammatory drug use and the risk of Parkinson's disease.
abstract: BACKGROUND
  Experimental evidence supports a preventative role for non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease (PD).
  
  
  METHODS
  We investigated associations between use of aspirin, nonaspirin NSAIDs, and acetaminophen and PD in a large population-based case-control study using Danish health and pharmacy registries. We identified 1,931 PD cases reported in hospital or outpatient clinic records who had received a primary diagnosis of PD between 2001 and 2006, and 9,651 age- and sex-matched controls from the Danish population register. Prescription medication use was documented in a pharmacy database covering all residents of Denmark since 1995.
  
  
  RESULTS
  Adjusting for age, sex, use of cardiovascular disease drugs, diagnosis of chronic pulmonary obstructive disorder, and Charlson comorbidity scores, and excluding prescriptions filled within 5 years before diagnosis, we found no evidence for an association between PD and either aspirin use (OR = 0.97; 95% CI 0.82, 1.14) or nonaspirin NSAID use (OR = 0.97; 95% CI 0.86, 1.09), regardless of intensity of use; further, there was no association between use of ibuprofen or acetaminophen and PD.
  
  
  CONCLUSIONS
  Our findings provide no evidence for a protective effect of nonaspirin and aspirin NSAID prescription drug use shortly before PD onset.
authors.affiliation: Department of Epidemiology, School of Public Health, UCLA, Los Angeles, CA 90095–1772, USA.
authors.forename: Angelika D
authors.initials: AD
authors.lastname: Manthripragada
authors.forename: Eva S
authors.initials: ES
authors.lastname: Schernhammer
authors.forename: Jiaheng
authors.initials: J
authors.lastname: Qiu
authors.forename: Soren
authors.initials: S
authors.lastname: Friis
authors.forename: Lene
authors.initials: L
authors.lastname: Wermuth
authors.forename: Jorgen H
authors.initials: JH
authors.lastname: Olsen
authors.forename: Beate
authors.initials: B
authors.lastname: Ritz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D016022:Case-Control Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control*; D012042:Registries; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin