title: Antioxidant, total phenolic content and cytotoxicity evaluation of selected Malaysian plants.
abstract: Aqueous and ethanol extracts of different traditional Malaysian plants (Polygonum minus, Andrographis paniculata, Curcuma xanthorrhiza, Momordica charantia and Strobilanthes crispus) were evaluated for their antioxidant properties, total phenolic content and cytotoxic activity. Antioxidant activity was evaluated by using 1,1-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. The results showed that ethanol extracts contain high antioxidant activities compared to aqueous extracts. The findings exhibited a strong correlation between antioxidant activity and the total phenol contents. In addition, all the plant extracts showed non-toxic effects against a normal human lung fibroblast cell line (Hs888Lu). Although traditionally aqueous extracts are used, we determined that ethanol extracts usually achieved better activity in the assays.
authors.affiliation: Department of Biological Science, Faculty of Biosciences and Bioengineering, University of Technology Malaysia, 81310, UTM Skudai, Johor, Malaysia. suhaylaqadir@yahoo.com
authors.forename: Suhailah Wasman
authors.initials: SW
authors.lastname: Qader
authors.forename: Mahmood Ameen
authors.initials: MA
authors.lastname: Abdulla
authors.forename: Lee Suan
authors.initials: LS
authors.lastname: Chua
authors.forename: Nigar
authors.initials: N
authors.lastname: Najim
authors.forename: Mazatulikhma Mat
authors.initials: MM
authors.lastname: Zain
authors.forename: Salehhuddin
authors.initials: S
authors.lastname: Hamdan
mesh_terms: D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008296:Malaysia; D010636:Phenols / Q000032:analysis / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010636:Phenols