title: Quality assurance and good laboratory practice.
abstract: Poor cell culture practice leads to poor science due largely to issues of cross-contamination between cell lines and of microbial contamination, but can be avoided by careful quality control and good laboratory practice. This chapter provides a brief and practical outline of the steps needed to mitigate the risks associated with poor cell culture practice. Good Laboratory Practice (GLP) is a set of principles that provides a framework within which laboratory studies are planned, performed, monitored, recorded, reported, and archived to ensure the reliability of data generated within a compliant laboratory. A key feature of this is the generation of quality-control methods and data management within the cell culture laboratory.
authors.affiliation: Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth, UK.
authors.forename: Louise A
authors.initials: LA
authors.lastname: Knight
authors.forename: Ian A
authors.initials: IA
authors.lastname: Cree
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000592:standards*; D002460:Cell Line; D006801:Humans; D007753:Laboratories / Q000592:standards*; D011786:Quality Control