title: Impact of renal failure on the tumor markers of mesothelioma, N-ERC/mesothelin and osteopontin.
abstract: BACKGROUND
  Knowledge of the characteristics and effective use of tumour markers for mesothelioma is essential for early-stage diagnosis of mesothelioma. We examined whether renal dysfunction influences blood concentrations of promising new tumour markers, N-ERC/mesothelin (N-ERC) and osteopontin (OPN), to an important degree.
  
  
  METHODS
  Levels of serum N-ERC and plasma OPN in 32 patients with chronic renal dysfunction, 22 of whom were on hemodialysis (CKD group), and 102 healthy volunteers were measured.
  
  
  RESULTS
  Serum concentrations of N-ERC and plasma concentrations of OPN in the CKD group were significantly higher than those in volunteers, regardless of diabetes status and age. Blood concentrations of these markers increased as renal function decreased.
  
  
  CONCLUSIONS
  N-ERC and OPN concentrations are significantly influenced by renal function. Therefore, the extent of renal failure must be considered when inferring the existence of tumours and chemotherapeutic response from the values of these markers in routine practice.
authors.affiliation: Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan. kazusatoko@gmail.com
authors.forename: Kazu
authors.initials: K
authors.lastname: Shiomi
authors.forename: Satoko
authors.initials: S
authors.lastname: Shiomi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishinaga
authors.forename: Motoki
authors.initials: M
authors.lastname: Sakuraba
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hagiwara
authors.forename: Kazuya
authors.initials: K
authors.lastname: Miyashita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Maeda
authors.forename: Kenji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takahashi
authors.forename: Okio
authors.initials: O
authors.lastname: Hino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood*; D006801:Humans; D008297:Male; D000090204:Mesothelin; D008654:Mesothelioma / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D011379:Prognosis; D051437:Renal Insufficiency / Q000097:blood* / Q000209:etiology; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D053495:Osteopontin; D000090204:Mesothelin