title: Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44.
abstract: A novel triazole carboxylic acid, penipanoid A (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), and a very recently reported quinazolinone derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated by spectroscopic analysis, and the structure for 1 was confirmed by X-ray crystallographic analysis. Compound 1 represents the first example of a triazole derivative from marine sediment-derived fungi, and compound 2 is a rare quinazolinone derivative having a dihydroimidazole ring system. The cytotoxicity of compounds 1 and 4 and the antimicrobial activity of 1-4 were evaluated.
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, People's Republic of China.
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: An
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Li
authors.forename: Shu-Shan
authors.initials: SS
authors.lastname: Gao
authors.forename: Chuan-Ming
authors.initials: CM
authors.lastname: Cui
authors.forename: Hao-Fen
authors.initials: HF
authors.lastname: Sun
authors.forename: Bin-Gui
authors.initials: BG
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002264:Carboxylic Acids; D004354:Drug Screening Assays, Antitumor; D019015:Geologic Sediments / Q000737:chemistry; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D052999:Quinazolinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014230:Triazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D007093:Imidazoles; D052999:Quinazolinones; D014230:Triazoles; C560319:penipanoid A; C560320:penipanoid B; C560321:penipanoid C