title: [Studying erythrocyte deformation by optical methods].
abstract: Erythrocyte deformation is an important factor of the microcirculation in physiological and pathophysiological conditions.
  
  
  METHODS
  Deformability was evaluated through the elongation index (IE) using two instruments based on optical methods: LORCA and RHEODYN-SSD.
  
  
  RESULTS
  The elongation index (IE) was compared for normal red blood cell (RBC) and heated RBC at 49 degrees C for 9, 30, 60 minutes duration. Erythrocyte deformability was measured for RBC treated with diamide (two concentrations), too. The results show that the increase of the diamide concentration induces the increase of the rigidity and a decreased deformability through the decreased IE. The elongation index was found decreasing as long as the time of heating is bigger, the RBC becoming more rigid.
authors.affiliation: Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi Facultatea de Farmacie, Disciplina de Fizică.
authors.forename: Diana
authors.initials: D
authors.lastname: Lăcătuşu
authors.forename: V
authors.initials: V
authors.lastname: Rusu
mesh_terms: D000328:Adult; D000465:Algorithms; D003958:Diamide / Q000494:pharmacology; D004907:Erythrocyte Deformability; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D055095:Optics and Photonics / Q000379:methods*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D012984:Software
chemical_list: D011838:Radiation-Sensitizing Agents; D003958:Diamide