title: Use of antibiotics in uncomplicated diverticulitis.
abstract: BACKGROUND
  The value of antibiotics in the treatment of acute uncomplicated left-sided diverticulitis is not well established. The aim of this review was to assess whether or not antibiotics contribute to the (uneventful) recovery from acute uncomplicated left-sided diverticulitis, and which types of antibiotic and route of administration are most effective.
  
  
  METHODS
  Medline, the Cochrane Library and Embase databases were searched. Randomized controlled trials (RCTs), prospective or retrospective cohort studies addressing conservative treatment of mild uncomplicated left-sided diverticulitis and use of antibiotics were included.
  
  
  RESULTS
  No randomized or prospective studies were found on the topic of effect on outcome. One retrospective cohort study was retrieved that compared a group treated with antibiotics with observation alone. This study showed no difference in success rate between groups. Only one RCT of moderate quality compared intravenous and oral administration of antibiotics, and found no differences. One other RCT of very poor quality compared two different kinds of intravenous antibiotic and also found no difference. A small retrospective cohort study comparing antibiotics with and without anaerobe coverage showed no difference in group outcomes.
  
  
  CONCLUSIONS
  Evidence on the use of antibiotics in mild or uncomplicated diverticulitis is sparse and of low quality. There is no evidence mandating the routine use of antibiotics in uncomplicated diverticulitis, although several guidelines recommend this. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
authors.affiliation: Department of Surgery, Kennemer Gasthuis, 2000 AK Haarlem, The Netherlands. ndekorte@yahoo.com
authors.forename: N
authors.initials: N
authors.lastname: de Korte
authors.forename: C
authors.initials: C
authors.lastname: Unlü
authors.forename: M A
authors.initials: MA
authors.lastname: Boermeester
authors.forename: M A
authors.initials: MA
authors.lastname: Cuesta
authors.forename: B C
authors.initials: BC
authors.lastname: Vrouenreats
authors.forename: H B A C
authors.initials: HB
authors.lastname: Stockmann
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004239:Diverticulitis, Colonic / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents