title: A roadmap for successful applications of clinical proteomics.
abstract: Despite over 30,000 publications on proteomics in the last decade, and the accumulation of extensive interesting information on the human proteome in diverse observations, the clinical translation of proteomics to-date has had major setbacks. I review here a roadmap for improving the success rate of clinical proteomics. The roadmap includes steps for improvements that need to be made in analytical tools, discovery, validation, clinical application, and post-clinical application appraisal. It is likely that most if not all of the components that are necessary for clinical success are either readily available, or should be possible to put in place with more rigorous research standards and concerted efforts of the research community, clinicians, and health agencies. Enthusiasm for the clinical impact of proteomics may need to be tempered currently until robust evidence can be obtained, but some clinical successes should eventually be feasible.
authors.affiliation: Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA. jioannid@stanford.edu
authors.forename: John P A
authors.initials: JP
authors.lastname: Ioannidis
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D040901:Proteomics / Q000379:methods*; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers