title: LINGO1 gene analysis in Parkinson's disease phenotypes.
abstract: BACKGROUND
  Parkinson's disease (PD) and essential tremor (ET) may share some etiopathogenic factors. A genome-wide association study has shown that LINGO1 gene variants are associated with increased risk of ET. We hypothesized that LINGO1 variants could increase susceptibility to PD.
  
  
  METHODS
  A large series of PD subjects and healthy controls were genotyped for rs9652490 and rs11856808 LINGO1 single nucleotide polymorphisms (SNPs).
  
  
  RESULTS
  We found an increased frequency of the rs11856808(T/T) genotype in PD compared with controls (odds ratio = 1.46; corrected P value = 0.02). A recessive genetic model was the best fit for rs11856808 influence on PD (recessive gene action test: corrected P value = 0.01). Stratification analysis showed that rs11856808(T/T) genotype frequency was higher in the tremor-dominant PD and the classical PD (C-PD) subgroups (recessive gene action test for the C-PD subgroup: corrected P value = 0.004).
  
  
  CONCLUSIONS
  Our results indicate that LINGO1 variants could increase risk of PD, specifically those presenting the non-rigid-akinetic phenotypes, which suggests that LINGO1 may have a role in the etiology of tremor in PD at least in the Spanish population.
authors.affiliation: Division of Neurosciences, Neurogenetics Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
authors.forename: Oswaldo
authors.initials: O
authors.lastname: Lorenzo-Betancor
authors.forename: Lluís
authors.initials: L
authors.lastname: Samaranch
authors.forename: Elena
authors.initials: E
authors.lastname: García-Martín
authors.forename: Sebastián
authors.initials: S
authors.lastname: Cervantes
authors.forename: José A G
authors.initials: JA
authors.lastname: Agúndez
authors.forename: Félix J
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: Hortensia
authors.initials: H
authors.lastname: Alonso-Navarro
authors.forename: Antonio
authors.initials: A
authors.lastname: Luengo
authors.forename: Francisco
authors.initials: F
authors.lastname: Coria
authors.forename: Elena
authors.initials: E
authors.lastname: Lorenzo
authors.forename: Jaione
authors.initials: J
authors.lastname: Irigoyen
authors.forename: Pau
authors.initials: P
authors.lastname: Pastor
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013030:Spain; D055815:Young Adult
chemical_list: C482293:LINGO1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins