title: Enantioselective α-amination of branched aldehydes promoted by simple chiral primary amino acids.
abstract: A series of simple chiral primary amino acids were first successfully applied to promote the enantioselective α-amination of branched aldehydes with azadicarboxylates and the desired adducts bearing quaternary stereogenic centers were obtained in excellent yields (up to 99%) and enantioselectivities (up to 97% ee).
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China.
authors.forename: Ji-Ya
authors.initials: JY
authors.lastname: Fu
authors.forename: Qing-Chuan
authors.initials: QC
authors.lastname: Yang
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Wang
authors.forename: Jun-Nan
authors.initials: JN
authors.lastname: Ming
authors.forename: Fei-Ying
authors.initials: FY
authors.lastname: Wang
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Xu
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000586:Amination; D000596:Amino Acids / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000447:Aldehydes; D000596:Amino Acids