title: The genetics of recurrent hydatidiform moles in China: correlations between NLRP7 mutations, molar genotypes and reproductive outcomes.
abstract: Hydatidiform mole (HM) is a human pregnancy with abnormal embryonic development. NLRP7 is a major autosomal recessive gene responsible for recurrent molar pregnancies and associated reproductive wastage in patients from several populations. Here, we report NLRP7 mutation analysis in 35 unrelated Chinese patients with recurrent reproductive wastage, including at least one HM. We describe three new protein-truncating mutations in NLRP7 and show the presence of three founder mutations in China and Asian populations. We determined the parental contribution to six molar tissues and show the occurrence of three diploid androgenetic moles in patients with one defective allele, while three diploid biparental moles occurred in patients with two defective alleles. We document the failure of pregnancies after assisted reproductive technologies (ARTs) in three patients with two defective alleles each and a successful pregnancy in one of two patients with one defective allele. Our data suggest that patients with a single defective allele have better reproductive outcomes than patients with two defective alleles, and some of them may benefit from ART.
authors.affiliation: Women's Reproductive Health Laboratory, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Qian
authors.forename: Qi
authors.initials: Q
authors.lastname: Cheng
authors.forename: Sharlene
authors.initials: S
authors.lastname: Murdoch
authors.forename: Chengming
authors.initials: C
authors.lastname: Xu
authors.forename: Fan
authors.initials: F
authors.lastname: Jin
authors.forename: Wafaa
authors.initials: W
authors.lastname: Chebaro
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhang
authors.forename: Huijuan
authors.initials: H
authors.lastname: Gao
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhu
authors.forename: Rima
authors.initials: R
authors.lastname: Slim
authors.forename: Xing
authors.initials: X
authors.lastname: Xie
mesh_terms: D000022:Abortion, Spontaneous; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000483:Alleles; D001483:Base Sequence; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis / Q000235:genetics*; D009154:Mutation; D010375:Pedigree; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted; D017422:Sequence Analysis, DNA
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C502448:NLRP7 protein, human