title: Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs).
abstract: Tenofovir, a well-known and highly prescribed anti-HIV-1 drug for the treatment of HIV/AIDS infections, has recently also shown its effectiveness as a potential microbicide drug in the prevention of HIV transmission. Here, we evaluated the combination of tenofovir with various members of the class of carbohydrate-binding agents (CBAs) targeting the glycans on the viral envelope gp120 for their anti-HIV efficacy. The tenofovir/CBA combinations predominantly showed synergistic antiviral activity using the median effect principle. These findings illustrate that combination of tenofovir with CBAs may increase the antiviral potency of the individual drugs and reducing the risk on potential side-effects.
authors.affiliation: Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium. geoffrey.ferir@rega.kuleuven.be
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Férir
authors.forename: Kurt
authors.initials: K
authors.lastname: Vermeire
authors.forename: Dana
authors.initials: D
authors.lastname: Huskens
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Els J M
authors.initials: EJ
authors.lastname: Van Damme
authors.forename: Jan-Christoph
authors.initials: JC
authors.lastname: Kehr
authors.forename: Elke
authors.initials: E
authors.lastname: Dittmann
authors.forename: Michael D
authors.initials: MD
authors.lastname: Swanson
authors.forename: David M
authors.initials: DM
authors.lastname: Markovitz
authors.forename: Dominique
authors.initials: D
authors.lastname: Schols
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000494:pharmacology*; D002460:Cell Line; D004357:Drug Synergism; D015699:HIV Envelope Protein gp120 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D063065:Organophosphonates / Q000494:pharmacology*; D000068698:Tenofovir
chemical_list: D019380:Anti-HIV Agents; D015699:HIV Envelope Protein gp120; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine