title: Comparison of solute-binding properties of plastic materials used as pharmaceutical product containers.
abstract: Material/water equilibrium binding constants (E(b)) were determined for 11 organic solutes and 2 plastic materials commonly used in pharmaceutical product containers (plasticized polyvinyl chloride and polyolefin). In general, solute binding by the plasticized polyvinyl chloride material was greater, by nearly an order of magnitude, than the binding by the polyolefin (on an equal weight basis). The utilization of the binding constants to facilitate container compatibility assessments (e.g., drug loss by container binding) for drug-containing products is discussed.
authors.affiliation: Baxter Healthcare Corporation, Route 120 and Wilson Road, Round Lake, IL 60073.
authors.forename: Dennis
authors.initials: D
authors.lastname: Jenke
authors.forename: Tom
authors.initials: T
authors.lastname: Couch
authors.forename: Amy
authors.initials: A
authors.lastname: Gillum
mesh_terms: D004349:Drug Packaging; D004364:Pharmaceutical Preparations; D010968:Plasticizers / Q000737:chemistry; D010969:Plastics / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry; D019064:Product Packaging; D012965:Sodium Chloride; D012996:Solutions / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations; D010968:Plasticizers; D010969:Plastics; D012996:Solutions; D012965:Sodium Chloride; D011143:Polyvinyl Chloride