title: Radiosynthesis of a new PSMA targeting ligand ([18F]FPy-DUPA-Pep).
abstract: Due to the specificity of expression of PSMA (prostate specific membrane antigen) particularly in prostate cancer cells (e.g. LNCaP), numerous PSMA ligands have been synthesized until now. In the current study, we synthesized DUPA-Pep having 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) linked via 8-aminooctanoic acid to two phenylalanine residues and chose 6-[(18)F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester [(18)F]FPy-TFP as a prosthetic group for coupling. [(18)F]FPy-DUPA-Pep was obtained in a radiochemical yield of 48±0.9% (decay uncorrected) within 50 min with a chemical purity of >98%.
authors.affiliation: Clinic for Nuclear Medicine, University Hospital, Ulm, Germany. noeen.malik@uniklinik-ulm.de
authors.forename: Noeen
authors.initials: N
authors.lastname: Malik
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Machulla
authors.forename: Christoph
authors.initials: C
authors.lastname: Solbach
authors.forename: Gordon
authors.initials: G
authors.lastname: Winter
authors.forename: Sven N
authors.initials: SN
authors.lastname: Reske
authors.forename: Boris
authors.initials: B
authors.lastname: Zlatopolskiy
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005462:Fluorine Radioisotopes / Q000378:metabolism*; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism*; D008024:Ligands; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D000954:Antigens, Surface; D005462:Fluorine Radioisotopes; D008024:Ligands; D019275:Radiopharmaceuticals; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II