title: Implications of corticotropin releasing factor in targeted anticancer therapy.
abstract: There is a need to develop novel anticancer therapies that eliminate adverse side effects produced by current treatments. Corticotropin releasing factor (CRF), an endogenous neuroedocrine factor, which typically regulates biological and psychological indicators of stress, has recently been found to be expressed by tumor malignancies. Here, we discuss the implications of CRF as a target for antitumor therapy through regulation of tumor immune escape mechanisms.
authors.affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
authors.forename: Byung-Jin
authors.initials: BJ
authors.lastname: Kim
authors.forename: Harlan P
authors.initials: HP
authors.lastname: Jones
mesh_terms: D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000502:physiology*; D019139:Tumor Escape / Q000187:drug effects*
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone; D003346:Corticotropin-Releasing Hormone