title: Philadelphicalactones C and D and other cytotoxic compounds from Physalis philadelphica.
abstract: Two new withanolides, philadelphicalactone C (1) and philadelphicalactone D (4), along with the known withaphysacarpin (3), ixocarpanolide (5), philadelphicalactone A (6), and ixocarpalactone A (7) were isolated from the aerial parts of Physalis philadelphica Lam. Structures of these compounds were determined by spectroscopic analyses and that of philadelphicalactone C (1) was confirmed by X-ray crystallographic analysis. Evaluation of the cytotoxic activity of all isolates and the derivative 2 against a panel of human cancer cell lines indicated a potent activity of compounds 2, 3, 6, and 7.
authors.affiliation: Instituto de Química, Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510, D. F., Mexico. emmaldon@unam.mx
authors.forename: Emma
authors.initials: E
authors.lastname: Maldonado
authors.forename: Ana L
authors.initials: AL
authors.lastname: Pérez-Castorena
authors.forename: Consuelo
authors.initials: C
authors.lastname: Garcés
authors.forename: Mahinda
authors.initials: M
authors.lastname: Martínez
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D032321:Physalis / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D007783:Lactones