title: Interim follow-up of a randomized controlled trial comparing Chinese style mind body (Tai Chi) and stretching exercises on cognitive function in subjects at risk of progressive cognitive decline.
abstract: OBJECTIVE
  We reported the interim findings of a randomized controlled trial (RCT) to examine the effects of a mind body physical exercise (Tai Chi) on cognitive function in Chinese subjects at risk of cognitive decline.
  
  
  METHODS
  389 Chinese older persons with either a Clinical Dementia Rating (CDR 0.5) or amnestic-MCI participated in an exercise program. The exercise intervention lasted for 1 year; 171 subjects were trained with 24 forms simplified Tai Chi (Intervention, I) and 218 were trained with stretching and toning exercise (Control, C). The exercise comprised of advised exercise sessions of at least three times per week.
  
  
  RESULTS
  At 5th months (2 months after completion of training), both I and C subjects showed an improvement in global cognitive function, delayed recall and subjective cognitive complaints (paired t-tests, p < 0.05). Improvements in visual spans and CDR sum of boxes scores were observed in I group (paired t-tests, p < 0.001). Three (2.2%) and 21(10.8%) subjects from the I and C groups progressed to dementia (Pearson chi square = 8.71, OR = 5.34, 95% CI 1.56-18.29). Logistic regression analysis controlled for baseline group differences in education and cognitive function suggested I group was associated with stable CDR (OR = 0.14, 95%CI = 0.03-0.71, p = 0.02).
  
  
  CONCLUSIONS
  Our interim findings showed that Chinese style mind body (Tai Chi) exercise may offer specific benefits to cognition, potential clinical interests should be further explored with longer observation period.
authors.affiliation: Department of Psychiatry, the Chinese University of Hong Kong, China. cwlam@cuhk.edu.hk
authors.forename: Linda C W
authors.initials: LC
authors.lastname: Lam
authors.forename: Rachel C M
authors.initials: RC
authors.lastname: Chau
authors.forename: Billy M L
authors.initials: BM
authors.lastname: Wong
authors.forename: Ada W T
authors.initials: AW
authors.lastname: Fung
authors.forename: Victor W C
authors.initials: VW
authors.lastname: Lui
authors.forename: Cindy C W
authors.initials: CC
authors.lastname: Tam
authors.forename: Grace T Y
authors.initials: GT
authors.lastname: Leung
authors.forename: Timothy C Y
authors.initials: TC
authors.lastname: Kwok
authors.forename: Helen F K
authors.initials: HF
authors.lastname: Chiu
authors.forename: Sammy
authors.initials: S
authors.lastname: Ng
authors.forename: W M
authors.initials: WM
authors.lastname: Chan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000523:psychology / Q000628:therapy*; D003704:Dementia / Q000523:psychology / Q000628:therapy; D018450:Disease Progression; D005260:Female; D006293:Health Promotion / Q000379:methods; D006801:Humans; D008297:Male; D052580:Muscle Stretching Exercises / Q000379:methods*; D011569:Psychiatric Status Rating Scales; D026302:Tai Ji / Q000379:methods*