title: Recent advances on the role of cytokines in atherosclerosis.
abstract: Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and adaptive immune responses. Inflammation controls the development and the destabilization of arterial plaque. Cells involved in the atherosclerotic process secrete and are activated by soluble factors, known as cytokines. Important recent advances in the comprehension of the mechanisms of atherosclerosis have provided evidence for a dual role of cytokines: proinflammatory and T helper-1-related cytokines promote the development and progression of the disease, whereas antiinflammatory and regulatory T cell-related cytokines exert clear antiatherogenic activities. This review focuses on recent advances regarding the role of cytokines, with the exception of chemokines, in the development, progression, and complications of atherosclerosis.
authors.affiliation: PARCC-INSERM U970, 56 rue Leblanc, 75015 Paris, France.
authors.forename: Hafid
authors.initials: H
authors.lastname: Ait-Oufella
authors.forename: Soraya
authors.initials: S
authors.lastname: Taleb
authors.forename: Ziad
authors.initials: Z
authors.lastname: Mallat
authors.forename: Alain
authors.initials: A
authors.lastname: Tedgui
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology*; D018836:Inflammation Mediators / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators