title: Pd-catalyzed intermolecular C-H amination with alkylamines.
abstract: C-H amination of N-aryl benzamides with O-benzoyl hydroxylamines has been achieved with either Pd(II) or Pd(0) catalysts. Furthermore, we demonstrate that secondary amines can be directly used with benzoyl peroxide in a one-pot procedure that proceeds via the in situ generation of the appropriate O-benzoyl hydroxylamines. This catalytic reaction provides a new disconnection for the convergent synthesis of tertiary and secondary arylalkyl amines starting from benzoic acids.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Yoo
authors.forename: Sandy
authors.initials: S
authors.lastname: Ma
authors.forename: Tian-Sheng
authors.initials: TS
authors.lastname: Mei
authors.forename: Kelvin S L
authors.initials: KS
authors.lastname: Chan
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu