title: Dual function inhibitors of relevance to chronic obstructive pulmonary disease.
abstract: The general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are described. The synthesis and in vitro biochemical evaluation of a dual function molecule that sequentially inhibits HNE and caspase-1 in a time-dependent manner is reported.
authors.affiliation: Department of Chemistry, Wichita State University, Wichita, KS 67260, USA.
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Dou
authors.forename: Guijia
authors.initials: G
authors.lastname: He
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Alliston
authors.forename: William C
authors.initials: WC
authors.lastname: Groutas
mesh_terms: D020134:Catalytic Domain; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009504:Neutrophils / Q000201:enzymology / Q000378:metabolism; D010196:Pancreatic Elastase / Q000378:metabolism; D011480:Protease Inhibitors / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism*; D013997:Time Factors
chemical_list: D011480:Protease Inhibitors; D010196:Pancreatic Elastase