title: Follicular variant of peripheral T-cell lymphoma mimicking follicular lymphoma: a case report with a review of the Literature.
abstract: Peripheral T-cell lymphoma (PTCL) with a follicular growth pattern is very rare. Herein, a case of follicular variant of PTCL in a 50-year-old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cells, medium to large in size, with abundant pale cytoplasm. The lymphoma cells were CD3(+) CD4(+) CD5(+) CD8(-) CD10(+) CD56(-) CD57(-) BCL6(+) PD-1(+) CXCL13(+) and were associated with a meshwork of CD21(+) follicular dendritic cells. Molecular studies revealed clonal rearrangement of the T-cell receptor gamma chain gene but not of the immunoglobulin gene. Cytogenetic analysis disclosed a complex abnormality in 18 of 20 cells with the exclusion of t(5; 9). These findings suggest that the present case is a follicular variant of PTCL derived from follicular T-helper cells.
authors.affiliation: First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan. naoegoto@gifu-u.ac.jp
authors.forename: Naoe
authors.initials: N
authors.lastname: Goto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tsurumi
authors.forename: Michio
authors.initials: M
authors.lastname: Sawada
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kanemura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hara
authors.forename: Senji
authors.initials: S
authors.lastname: Kasahara
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kito
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Takada
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Sato
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.forename: Hisataka
authors.initials: H
authors.lastname: Moriwaki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takami
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D020566:Dendritic Cells, Follicular / Q000276:immunology; D003937:Diagnosis, Differential; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D016176:T-Lymphocyte Subsets / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D015703:Antigens, CD