title: CT-guided single high-dose percutaneous acetic acid injection for small hepatocellular carcinoma: a long-term follow-up study.
abstract: OBJECTIVE
  To evaluate the long-term outcome of CT-guided single high-dose percutaneous acetic acid injection (PAI) for the treatment of small hepatocellular carcinoma (SHCC).
  
  
  METHODS
  Sixty-eight consecutive patients (37 men and 31 women; age 52 ± 16 years) with SHCC have undergone CT-guided single high-dose PAI therapy since December 2000. Complications of high-dose PAI were recorded. Tumour survival and recurrence rates were assessed.
  
  
  RESULTS
  All PAI therapies were successful and no severe complications developed. The average follow-up period was 46 ± 18 months. The overall survival rates at 1, 2, 3, 4 and 5 years were 93%, 82%, 68%, 59% and 51%, respectively. The cumulative local recurrence rates for the main tumour at 1, 2, 3, 4 and 5 years were 18%, 22%, 25%, 28% and 28%, respectively. The cumulative new tumour recurrence rates at 1, 2, 3, 4 and 5 years were 24%, 40%, 43%, 60% and 62%, respectively.
  
  
  CONCLUSIONS
  CT-guided single high-dose PAI is safe and effective for the treatment of SHCC after long-term follow-up.
authors.affiliation: Yuhuangding Hospital, No 20, Yuhuangding East Road, Yantai, Shandong Province 264000, China. hengma001@yahoo.com.cn
authors.forename: Heng
authors.initials: H
authors.lastname: Ma
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Fengli
authors.initials: F
authors.lastname: Liu
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D015641:Radiography, Interventional; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019342:Acetic Acid