title: Leishmania parasites act as a Trojan horse that paralyzes the translation system of host macrophages.
abstract: GP63 is an abundant GPI-anchored surface metalloprotease of Leishmania. Jaramillo et al. (2011) show that GP63 manipulates the translation system of host macrophages by cleaving mTOR, which leads to 4E-BP1 dephosphorylation. This study pioneers the observation that Leishmania parasites metabolically paralyze their host cells using an elegant translation shutoff mechanism.
authors.affiliation: Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel. shapiram@bgu.ac.il
authors.forename: Michal
authors.initials: M
authors.lastname: Shapira
authors.forename: Alexandra
authors.initials: A
authors.lastname: Zinoviev