title: [Risk factors of gastropathy development in workers exposed to dust].
abstract: Systemic leucocyte-induced oxidative stress in prolonged occupational exposure to dust modifies oxidative metabolism of neutrophils and RBC, causes inflammatory and destructive, autoimmune processes in gastric lining and possible subsequent occupational gastropathies. To verify gastropathies caused by technogenic dust aerosols, search of preclinical biologic markers of gastric lining damage is essential. The article presents main steps in occupational gastropathies formation, trigger mechanisms, leading pathogenetic factors of gastric lining damage and of atrophic fundus gastritis. Using the mentioned complex of biomarkers in gastric lining state monitoring among workers at periodic and thorough medical examination is main item in forecasting individual risk of occupational gastropathies and in possible approach to their prevention and treatment.
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Dorn
authors.forename: S A
authors.initials: SA
authors.lastname: Peskov
authors.forename: E L
authors.initials: EL
authors.lastname: Poteriaeva
authors.forename: E A
authors.initials: EA
authors.lastname: Tsikalenko
authors.forename: A B
authors.initials: AB
authors.lastname: Maslennikov
authors.forename: E L
authors.initials: EL
authors.lastname: Smirnova
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Poliakov
authors.forename: E V
authors.initials: EV
authors.lastname: Gerasimova
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis / Q000633:toxicity*; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000032:analysis; D004391:Dust; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005757:Gastritis, Atrophic / Q000139:chemically induced* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D009784:Occupational Diseases / Q000139:chemically induced* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D012307:Risk Factors; D017132:Workplace / Q000592:standards*
chemical_list: D000395:Air Pollutants, Occupational; D001323:Autoantibodies; D015415:Biomarkers; D004391:Dust