title: Recent patents on the synthesis and application of silica nanoparticles for drug delivery.
abstract: Drug delivery systems are designed to improve therapy efficacy as well as patient compliance. This could be accomplished by specifically targeting a medication intact to its active site, therefore reducing side-effects and enabling high local drug concentrations. Silica nanoparticles have gained ground in the biomedical field for their biocompatibility and biodegradability, being themselves inert and stable, thus enabling a variety of formulation designs for application in the pharmaceutical industry. This paper is a review of the recent patents on the applications of silica nanoparticles for drug delivery and their preparation. The review will focus on the different techniques available to obtain silica nanoparticles with variable morphology and their drug targeting applications, providing an overview of silica particles synthesis described in the literature.
authors.affiliation: IQUIMEFA-CONICET.Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina.
authors.forename: Maria Lucia
authors.initials: ML
authors.lastname: Foglia
authors.forename: Gisela Solange
authors.initials: GS
authors.lastname: Alvarez
authors.forename: Paolo Nicolás
authors.initials: PN
authors.lastname: Catalano
authors.forename: Andrea Mathilde
authors.initials: AM
authors.lastname: Mebert
authors.forename: Luís Eduardo
authors.initials: LE
authors.lastname: Diaz
authors.forename: Thibaud
authors.initials: T
authors.lastname: Coradin
authors.forename: Martín Federico
authors.initials: MF
authors.lastname: Desimone
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D006801:Humans; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D004364:Pharmaceutical Preparations; D012822:Silicon Dioxide