title: Unresectable multifocal omental and peritoneal inflammatory myofibroblastic tumor in a child: revisiting the role of adjuvant therapy.
abstract: Inflammatory myofibroblastic tumor is an uncommon lesion, also called pseudotumor, with a variable natural course from benign with spontaneous regression to mimicking malignant tumors. We report a case of diffuse peritoneal and omental pseudotumor in a 10-year-old boy characterized by aggressive behavior at the onset followed by stability after subtotal resection and chemotherapy. Total excision was not possible because of the tumor dissemination over the whole peritoneal surface. Adjuvant antiinflammatory drug (ketorolac tromethamine) and chemotherapy (methotrexate-vinblastine followed by ifosfamide-adriamycin and ifosfamide alone) were helpful to obtain rapidly complete resolution of clinical symptoms and anatomic stability of the residual lesions. Long-term evolution, in the absence of continued therapy, has been characterized by progressive involution and reduction of the residual masses.
authors.affiliation: Liver Surgery Unit, Bambino Gesù Children's Hospital, Rome - 00165, Italy.
authors.forename: Arianna
authors.initials: A
authors.lastname: Bertocchini
authors.affiliation: Hepatobiliary Radiology Unit, Bambino Gesù Children's Hospital, Rome - 00165, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Lo Zupone
authors.affiliation: Pathology Unit, Bambino Gesù Children's Hospital, Rome - 00165, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Callea
authors.affiliation: Liver Surgery Unit, Bambino Gesù Children's Hospital, Rome - 00165, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Gennari
authors.affiliation: Oncology Unit, Bambino Gesù Children's Hospital, Rome - 00165, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Serra
authors.affiliation: Hepatobiliary Radiology Unit, Bambino Gesù Children's Hospital, Rome - 00165, Italy.
authors.forename: Lidia
authors.initials: L
authors.lastname: Monti
authors.affiliation: Liver Surgery Unit, Bambino Gesù Children's Hospital, Rome - 00165, Italy; Paediatric surgery, University of Roma Tor Vergata, Roma - 00133, Italy. Electronic address: deville@opbg.net.
authors.forename: Jean
authors.initials: J
authors.lastname: de Ville de Goyet
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D002648:Child; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D005500:Follow-Up Studies; D006104:Granuloma, Plasma Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D009852:Omentum; D019152:Paracentesis / Q000379:methods; D010532:Peritoneal Diseases / Q000175:diagnosis / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D014747:Vinblastine; D004317:Doxorubicin; D007069:Ifosfamide; D008727:Methotrexate