title: Total (bio)synthesis: strategies of nature and of chemists.
abstract: The biosynthetic pathways to a number of natural products have been reconstituted in vitro using purified enzymes. Many of these molecules have also been synthesized by organic chemists. Here we compare the strategies used by nature and by chemists to reveal the underlying logic and success of each total synthetic approach for some exemplary molecules with diverse biosynthetic origins.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, La Jolla, CA 92093, USA.
authors.forename: Alexandra A
authors.initials: AA
authors.lastname: Roberts
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Ryan
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Moore
authors.forename: Tobias A M
authors.initials: TA
authors.lastname: Gulder
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry; D001419:Bacteria / Q000201:enzymology; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D032701:Biomimetics / Q000379:methods; D010619:Phenazines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D010944:Plants / Q000201:enzymology; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D017262:Siderophores / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000470:Alkaloids; D001688:Biological Products; D010619:Phenazines; D012717:Sesquiterpenes; D017262:Siderophores