title: Iron oxide mediated direct C-H arylation/alkylation at α-position of cyclic aliphatic ethers.
abstract: We report a new and efficient iron oxide catalyzed cross-coupling reaction between organometallic species such as alkyl/arylmagnesium halides or organolithium species and α-hydrogen bearing cyclic aliphatic ethers via activation of C(sp(3))-H. This is the first example of iron oxide mediated direct C-C bond formation without expensive or toxic ligands.
authors.affiliation: Medicinal Chemistry Division, Indian Institute of Integrative Medicine (Council of Scientific & Industrial Research), Jammu 180 001, India.
authors.forename: Parvinder Pal
authors.initials: PP
authors.lastname: Singh
authors.forename: Satish
authors.initials: S
authors.lastname: Gudup
authors.forename: Srinivas
authors.initials: S
authors.lastname: Ambala
authors.forename: Umed
authors.initials: U
authors.lastname: Singh
authors.forename: Sumit
authors.initials: S
authors.lastname: Dadhwal
authors.forename: Baldev
authors.initials: B
authors.lastname: Singh
authors.forename: Sanghapal D
authors.initials: SD
authors.lastname: Sawant
authors.forename: Ram A
authors.initials: RA
authors.lastname: Vishwakarma
mesh_terms: D000478:Alkylation; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D004988:Ethers, Cyclic / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry
chemical_list: D004988:Ethers, Cyclic; D005290:Ferric Compounds; C000499:ferric oxide; D002244:Carbon; D006859:Hydrogen