title: Relative associations of polycystic ovarian syndrome vs metabolic syndrome with thyroid function, volume, nodularity and autoimmunity.
abstract: BACKGROUND
  The relative associations of polycystic ovarian syndrome (PCOS) and metabolic syndrome (MS) with the risk for thyroid disease (thyroid function, volume, nodularity and autoimmunity) are unknown.We compared thyroid features and function in patients with PCOS and control subjects by the presence of MS.
  
  
  METHODS
  We recruited 84 women with PCOS and 81 age-matched healthy controls. PCOS was defined according to the Rotterdam criteria. Thyroid ultrasound and function tests were performed in all.
  
  
  RESULTS
  Although thyroid disease was more prevalent in women with PCOS, ovarian disease was not significantly associated with the risk for thyroid disease. Thyroid volume did not differ between women with PCOS and control subjects (13.7±8.6 vs 12.4±4.4 ml, respectively; p=0.2); however, it differed significantly between subjects with and without MS (regardless of PCOS status): 19.1±14.8 vs 12.4±4.9 ml, respectively; p=0.001). Antithyroglobulin and antithyroid peroxidase antibody levels also were significantly higher in subjects with MS, but not in participants with PCOS vs control subjects. Overall, TSH level correlated significantly with body mass index (BMI), weight, waist circumference, diastolic blood pressure, and levels of LDL cholesterol, triglycerides, and HDL cholesterol. Thyroid volume correlated significantly with age, weight, BMI, waist circumference, systolic blood pressure, 120-min postprandial glucose and HDL level.
  
  
  CONCLUSIONS
  PCOS alone was not associated with thyroid disease in our population. However, MS and some of its components appear to be related to thyroid volume, function, and antithyroid antibody levels.
authors.affiliation: Department of Endocrinology and Metabolism, Trabzon Numune Training and Research Hospital, Trabzon, Turkey. ianaforoglu@hotmail.com
authors.forename: I
authors.initials: I
authors.lastname: Anaforoglu
authors.forename: M
authors.initials: M
authors.lastname: Topbas
authors.forename: E
authors.initials: E
authors.lastname: Algun
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000473:pathology / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000473:pathology / Q000503:physiopathology*; D011446:Prospective Studies; D013959:Thyroid Diseases / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000033:anatomy & histology* / Q000276:immunology / Q000473:pathology* / Q000502:physiology*; D055105:Waist Circumference
chemical_list: D001323:Autoantibodies; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL