title: Clinical Responses and Prognostic Indicators of Concurrent Chemoradiation for Non-small Cell Lung Cancer.
abstract: OBJECTIVE
  To evaluate treatment outcomes and prognostic factors in non-small cell lung cancer (NSCLC) patients treated with concurrent chemoradiation.
  
  
  METHODS
  From January 2005 to June 2009, 51 patients were treated with concurrent chemoradiation for 3 different aims: locally advanced stage III, locally recurrent disease, and postoperative gross residual NSCLC. Median age was 63 years. Distribution of stages by the 6th edition of American Joint Committee on Cancer (AJCC) was as follows: IIIA (37.3%), IIIB (56.9%). Chemotherapy was administered every week concurrently with radiation using one of the following regimens: paclitaxel (60 mg/m(2)), docetaxel+cisplatin (20 mg/m(2)+20 mg/m(2)), cisplatin (30 mg/m(2)). Total radiation dose was 16-66.4 Gy (median, 59.4 Gy).
  
  
  RESULTS
  Median follow-up duration was 40.8 months. The overall response rate was 84.3% with 23 complete responses. The median survival duration for the overall patient group was 17.6 months. The 3-year survival rate was 17.8%. A total of 21 patients had recurrent disease at the following sites: loco-regional sites (23.6%), distant organs (27.5%). In the multivariate analysis of the overall patient group, a clinical tumor response (p=0.002) was the only significant prognostic factor for overall survival (OS). In the multivariate analysis of the definitive chemoradiation arm, the use of consolidation chemotherapy (p=0.022), biologically equivalent dose (BED)(10) (p=0.007), and a clinical tumor response (p=0.030) were the significant prognostic factors for OS.The median survival duration of the locally recurrent group and the postoperative gross residual group were 26.4 and 23.9 months, respectively.
  
  
  CONCLUSIONS
  Our study demonstrated that clinical tumor response was significantly associated with OS in the overall patient group. Further investigations regarding the optimal radiation dose in the definitive chemoradiation and the optimal treatment scheme in locally recurrent NSCLC would be required.
authors.affiliation: Department of Radiation Oncology, The Catholic University of Korea School of Medicine, Seoul, Korea.
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: Yeon-Sil
authors.initials: YS
authors.lastname: Kim
authors.forename: Jin-Hyoung
authors.initials: JH
authors.lastname: Kang
authors.forename: Sang-Nam
authors.initials: SN
authors.lastname: Lee
authors.forename: Young-Kyoun
authors.initials: YK
authors.lastname: Kim
authors.forename: Myung-Im
authors.initials: MI
authors.lastname: Ahn
authors.forename: Dae-Hee
authors.initials: DH
authors.lastname: Han
authors.forename: Ie-Ryung
authors.initials: IeR
authors.lastname: Yoo
authors.forename: Young-Pil
authors.initials: YP
authors.lastname: Wang
authors.forename: Jae-Gil
authors.initials: JG
authors.lastname: Park
authors.forename: Sei-Chul
authors.initials: SC
authors.lastname: Yoon
authors.forename: Hong-Seok
authors.initials: HS
authors.lastname: Jang
authors.forename: Byung-Oak
authors.initials: BO
authors.lastname: Choi