title: Intramolecular palladium-catalysed enolate arylation of 2- and 3-iodoindole derivatives for the synthesis of β-carbolines, γ-carbolines, and pyrrolo[3,4-b]indoles.
abstract: The palladium-catalysed intramolecular α-arylation of carbonyl compounds with amino-tethered 2- and 3-iodoindoles provides a useful methodology for the synthesis of indolo-b-fused nitrogen heterocycles. A variety of substituted tetrahydro β- and γ-carbolines, and pyrrolo[3,4-b]indoles, have been prepared by means of this palladium-catalysed annulation process.
authors.affiliation: Laboratori de Química Orgànica, Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII s/n, 08028, Barcelona, Spain. dsole@ub.edu
authors.forename: Daniel
authors.initials: D
authors.lastname: Solé
authors.forename: M-Lluïsa
authors.initials: ML
authors.lastname: Bennasar
authors.forename: Iván
authors.initials: I
authors.lastname: Jiménez
mesh_terms: D001688:Biological Products / Q000032:analysis / Q000138:chemical synthesis*; D002243:Carbolines / Q000032:analysis / Q000138:chemical synthesis*; D002384:Catalysis; D002626:Chemistry, Pharmaceutical; D007211:Indoles / Q000032:analysis / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011758:Pyrroles / Q000032:analysis / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D002243:Carbolines; D007211:Indoles; D011758:Pyrroles; C055572:gamma-carboline; D010165:Palladium