title: Comparison of ischemic and bleeding risk scores in non-ST elevation acute coronary syndromes.
abstract: OBJECTIVE
  Compare the discriminatory performance of two validated ischemic risk scores and a bleeding risk score for in-hospital adverse events across the spectrum of non-ST elevation acute coronary syndromes (NSTE-ACS).
  
  
  METHODS
  Single center, 516 consecutive patients admitted with the diagnosis of NSTE-ACS. The following risk scores were calculated for each patient: TIMI, GRACE and CRUSADE. The following in-hospital endpoints were used: major bleeding (as defined by the CRUSADE criteria); recurrent ischemia (re-infarction or recurrent angina); and death. Discriminatory performance was measured by the c-statistic and compared.
  
  
  RESULTS
  There were 36 major bleeding events, 34 recurrent ischemic events and 10 deaths. TIMI RS, GRACE RS, and CRUSADE RS demonstrated fair discriminatory accuracy for major bleeding (c-statistic = 0.64, 0.58, and 0.61, respectively). GRACE and CRUSADE risk scores demonstrated a better performance than TIMI RS for predicting in-hospital death (c-statistic = 0.92 and 0.86, respectively versus c-statistic = 0.63, P < 0.001). For the combined endpoint of in-hospital death or recurrent ischemia there was no statistically significant difference between CRUSADE RS, GRACE RS, and TIMI RS (c-statistic = 0.58, 0.57, and 0.62, respectively).
  
  
  CONCLUSIONS
  Both ischemic and bleeding risk scores are able to predict in-hospital bleeding, ischemic and fatal events.
authors.affiliation: Centro Hospitalar de Setúbal, Cardiologia, Setubal, Portugal. pmcamador@hotmail.com
authors.forename: Pedro
authors.initials: P
authors.lastname: Amador
authors.forename: Jose Ferreira
authors.initials: JF
authors.lastname: Santos
authors.forename: Sara
authors.initials: S
authors.lastname: Gonçalves
authors.forename: Filipe
authors.initials: F
authors.lastname: Seixo
authors.forename: Luis
authors.initials: L
authors.lastname: Soares
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications*; D000368:Aged; D004562:Electrocardiography; D005260:Female; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000209:etiology*; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods