title: Antitussive activity of Pseudostellaria heterophylla (Miq.) Pax extracts and improvement in lung function via adjustment of multi-cytokine levels.
abstract: Pseudostellaria heterophylla (Miq.) Pax is one of the most widespread herbal and healthcare products in China. Extensive clinical use has shown that it has functions which "strengthens qi and generates saliva, moistens the lung and relieves cough". The ethyl acetate fraction extracted from the roots of the plant Pseudostellaria heterophylla exhibited a dose-dependent antitussive effect between 100 to 500 mg/kg. At a dose of 400 mg/kg, the ethyl acetate fraction treatment markedly prolonged the cough latent period and reduced the number of coughs in a guinea pig model induced by citric acid. Fall lung airway resistance, rise in dynamic lung compliance, decreased serum levels of IL-8, GM-CSF, TNF-α, and ET-1 in rat model of stable phase chronic obstructive pulmonary disease induced by cigarette smoke exposure were also observed. These results suggest that ethyl acetate fraction has antitussive activity related to its improvement in lung function via attenuation of airway inflammation by adjustment of multi-cytokine levels.
authors.affiliation: School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350108, China. pws@fjtcm.edu.cn
authors.forename: Wensheng
authors.initials: W
authors.lastname: Pang
authors.forename: Siding
authors.initials: S
authors.lastname: Lin
authors.forename: Qiwen
authors.initials: Q
authors.lastname: Dai
authors.forename: Hongcheng
authors.initials: H
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Hu
mesh_terms: D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology*; D029748:Caryophyllaceae / Q000737:chemistry*; D003371:Cough / Q000517:prevention & control; D016207:Cytokines / Q000378:metabolism*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
chemical_list: D000996:Antitussive Agents; D016207:Cytokines; D010936:Plant Extracts