title: Efficient and facile formation of two-component nanoparticles via aromatic moiety directed self-assembly.
abstract: Here we present a two-component self-assembling system employing the interaction of aromatic groups (Fmoc) to construct nanoparticles. Spherical particles of around 70 nm were formed spontaneously by a simple trigonal Fmoc-conjugate, which were then stabilized by Fmoc-dipeptides at physiological pH in aqueous solution. These novel particles, being well-tolerated by cells, capable of encapsulating hydrophobic compounds, and readily decorated by short peptides, are promising carriers for drug delivery.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Chau
mesh_terms: D005449:Fluorenes / Q000737:chemistry; D057446:Hydrodynamics; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013050:Spectrometry, Fluorescence
chemical_list: C496789:9-fluorenylmethoxycarbonyl; D005449:Fluorenes