title: Persistence of individual variations in glycated hemoglobin: analysis of data from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Trial.
abstract: OBJECTIVE
  To determine the individual persistence of the relationship between mean sensor glucose (MG) concentrations and hemoglobin A(1c) (A1C) from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring (CGM) Randomized Trial.
  
  
  METHODS
  MG was calculated using CGM data for 3 months before A1C measurements at 3, 6, 9, and 12 months for the CGM group and at 9 and 12 months for the control group. An MG-to-A1C ratio was included in analysis for subjects who averaged ≥4 days/week of CGM use.
  
  
  RESULTS
  Spearman correlations of the MG-to-A1C ratio between consecutive visits 3 months apart ranged from 0.70 to 0.79. The correlations for children and youth were slightly smaller than those for adults. No meaningful differences were observed by device type or change in A1C.
  
  
  CONCLUSIONS
  Individual variations in the rate of hemoglobin glycation are persistent and contribute to the inaccuracy in estimating MGs calculated from A1C levels.
authors.affiliation: Division of Pediatric Endocrinology and Diabetes, Stanford University, Stanford, California, USA.
authors.forename: Darrell M
authors.initials: DM
authors.lastname: Wilson
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Xing
authors.forename: Jing
authors.initials: J
authors.lastname: Cheng
authors.forename: Roy W
authors.initials: RW
authors.lastname: Beck
authors.forename: Irl
authors.initials: I
authors.lastname: Hirsch
authors.forename: Craig
authors.initials: C
authors.lastname: Kollman
authors.forename: Lori
authors.initials: L
authors.lastname: Laffel
authors.forename: Jean M
authors.initials: JM
authors.lastname: Lawrence
authors.forename: Nelly
authors.initials: N
authors.lastname: Mauras
authors.forename: Katrina J
authors.initials: KJ
authors.lastname: Ruedy
authors.forename: Eva
authors.initials: E
authors.lastname: Tsalikian
authors.forename: Howard
authors.initials: H
authors.lastname: Wolpert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015190:Blood Glucose Self-Monitoring / Q000379:methods; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007328:Insulin; D007332:Insulin Infusion Systems; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin