title: A poly(acrylic acid)-block-poly(L-glutamic acid) diblock copolymer with improved cell adhesion for surface modification.
abstract: A novel PAA-b-PLGA diblock copolymer is synthesized and characterized that has excellent cell adhesion and biocompatibility. Fluorescent DiO labeling is used to monitor the attachment and growth of hASCs on the film surface, and cell proliferation over time is studied. Results show that PLLA modified by a CS/PAA-b-PLGA multilayer film can promote the attachment of human hASCs and provide an advantageous environment for their proliferation. The multilayer film presents excellent biocompatibility and cell adhesive properties, which will provide a new choice for improving the cell attachment in surface modification for tissue engineering. Hydroxyl, carboxyl and amine groups in the CS/PAA-b-PLGA multilayer film may be combined with drugs and growth factors for therapy and differentiation.
authors.affiliation: Department of Polymer Materials, Shanghai University, 20 Chengzhong Road, Jiading, Shanghai, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Cao
authors.forename: Shifeng
authors.initials: S
authors.lastname: Yan
authors.forename: Kunxi
authors.initials: K
authors.lastname: Zhang
authors.forename: Zhijiang
authors.initials: Z
authors.lastname: Song
authors.forename: Tian
authors.initials: T
authors.lastname: Cao
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Cui
authors.forename: Jingbo
authors.initials: J
authors.lastname: Yin
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D049109:Cell Proliferation; D002478:Cells, Cultured; D004337:Drug Carriers; D018698:Glutamic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D013234:Stem Cells / Q000378:metabolism; D013499:Surface Properties; D054457:Tissue Scaffolds
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D004337:Drug Carriers; D018698:Glutamic Acid; C006903:carbopol 940