title: Selective IgM deficiency in CD30+ cutaneous lymphoproliferative disorder.
abstract: Primary cutaneous anaplastic large cell lymphoma with local lymph node involvement was diagnosed in a 13-year-old boy with an ulcerative facial lesion and a history of skin lesions of lymphomatoid papulosis. The tumor regressed with chemotherapy. He continued to develop recurrent self-limited lesions of lymphomatoid papulosis , with a halo surrounding these lesions during the healing phase. He developed selective immunoglobulin M deficiency with decline in levels even 4 years after the chemotherapy with no recurrent infections noted and adequate IgG response to immunizations. Both peripheral blood IgM+ and memory B cells were low, suggesting a possible cause-effect relationship between selective immunoglobulin M deficiency and chronic CD30+ cutaneous lymphoproliferative disorders.
authors.affiliation: Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, MI, USA.
authors.forename: Surbhi
authors.initials: S
authors.lastname: Saini
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Dettore
authors.forename: Kanta J
authors.initials: KJ
authors.lastname: Bhambhani
authors.forename: Steven
authors.initials: S
authors.lastname: Buck
authors.forename: Janet
authors.initials: J
authors.lastname: Poulik
authors.forename: Süreyya
authors.initials: S
authors.lastname: Savaşan
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005153:Facial Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000172:deficiency*; D007156:Immunologic Memory / Q000276:immunology; D017730:Ki-1 Antigen / Q000378:metabolism*; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
chemical_list: D007075:Immunoglobulin M; D017730:Ki-1 Antigen