title: A new way APP mismetabolism can lead to Alzheimer's disease.
authors.affiliation: Reta Lilla Weston Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK. j.hardy@ion.ucl.ac.uk
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.forename: Rita
authors.initials: R
authors.lastname: Guerreiro
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D019943:Amino Acid Substitution / Q000235:genetics; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics* / Q000378:metabolism*; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism*; D007854:Lead; D008954:Models, Biological; D050505:Mutant Proteins / Q000235:genetics / Q000378:metabolism; D020125:Mutation, Missense
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D050505:Mutant Proteins; D007854:Lead; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human