title: Pressure ulcers.
abstract: BACKGROUND
  Unrelieved pressure or friction of the skin, particularly over bony prominences, can lead to pressure ulcers in up to one third of people in hospitals or community care, and one fifth of nursing home residents. Pressure ulcers are more likely in people with reduced mobility and poor skin condition, such as older people or those with vascular disease.
  
  
  METHODS
  We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of preventive interventions in people at risk of developing pressure ulcers? What are the effects of treatments in people with pressure ulcers? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2010 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
  
  
  RESULTS
  We found 64 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
  
  
  CONCLUSIONS
  In this systematic review we present information relating to the effectiveness and safety of the following interventions: air-filled vinyl boots, air-fluidised supports, alternating-pressure surfaces (including mattresses), alternative foam mattresses, constant low-pressure supports, debridement, electric profiling beds, electrotherapy, hydrocellular heel supports, low-air-loss beds (including hydrotherapy beds), low-level laser therapy, low-tech constant-low-pressure supports, medical sheepskin overlays, nutritional supplements, orthopaedic wool padding, pressure-relieving overlays on operating tables, pressure-relieving surfaces, repositioning (regular "turning"), seat cushions, standard beds, standard care, standard foam mattresses, standard tables, surgery, therapeutic ultrasound, topical lotions and dressings, topical negative pressure, and topical phenytoin.
authors.affiliation: Geriatric Medicine, University of California, San Francisco, CA, USA.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Reddy
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use; D001458:Bandages; D001512:Bedding and Linens; D001513:Beds; D003646:Debridement; D006801:Humans; D028022:Low-Level Light Therapy; D054843:Negative-Pressure Wound Therapy; D056888:Patient Positioning; D010672:Phenytoin / Q000008:administration & dosage / Q000627:therapeutic use; D003668:Pressure Ulcer / Q000517:prevention & control* / Q000628:therapy*; D059039:Standard of Care; D014464:Ultrasonic Therapy
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin