title: Synthesis and properties of triazole-linked RNA.
abstract: RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV melting and CD showed that triazole strongly destabilized RNA duplex (7-14°C per modification). NMR data suggested that, despite relative flexibility around the modified linkage, all base pairs were formed.
authors.affiliation: Department of Chemistry, Binghamton University, The State University of New York, Binghamton, NY 13902, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Mutisya
authors.forename: Chelliah
authors.initials: C
authors.lastname: Selvam
authors.forename: Scott D
authors.initials: SD
authors.lastname: Kennedy
authors.forename: Eriks
authors.initials: E
authors.lastname: Rozners
mesh_terms: D001483:Base Sequence; D002942:Circular Dichroism; D057930:Click Chemistry; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry*; D013696:Temperature; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D014230:Triazoles; D012313:RNA