title: Unique platinum-DNA interactions may lead to more effective platinum-based antitumor drugs.
abstract: Platinum coordination compounds are among the most utilized anticancer agents, even though platinum has not been determined to be an essential trace element in any living organism. The success of platinum-based drugs has catalyzed research on other metal-containing agents that can be used to achieve therapeutic goals that cannot be achieved with organic compounds. The antitumor activities of recently reported platinum(ii) complexes indicate that further modification of platinum coordination compounds will lead to the development of anticancer agents with higher efficacies against chemotherapy-insensitive tumors.
authors.affiliation: Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan. komedas@suzuka-u.ac.jp
authors.forename: Seiji
authors.initials: S
authors.lastname: Komeda
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D010984:Platinum / Q000378:metabolism* / Q000627:therapeutic use*; D055672:Static Electricity; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D010984:Platinum; D004247:DNA