title: Computer simulations for internal dosimetry using voxel models.
abstract: In the Japan Atomic Energy Agency, several studies have been conducted on the use of voxel models for internal dosimetry. Absorbed fractions (AFs) and S values have been evaluated for preclinical assessments of radiopharmaceuticals using human voxel models and a mouse voxel model. Computational calibration of in vivo measurement system has been also made using Japanese and Caucasian voxel models. In addition, for radiation protection of the environment, AFs have been evaluated using a frog voxel model. Each study was performed by using Monte Carlo simulations. Consequently, it was concluded that these data of Monte Carlo simulations and voxel models could adequately reproduce measurement results. Voxel models were found to be a significant tool for internal dosimetry since the models are anatomically realistic. This fact indicates that several studies on correction of the in vivo measurement efficiency for the variability of human subjects and interspecies scaling of organ doses will succeed.
authors.affiliation: Japan Atomic Energy Agency, 2-4 Shirakata-Shirane, Tokai-mura, Ibaraki 319-1195, Japan. kinase.sakae@jaea.go.jp
authors.forename: Sakae
authors.initials: S
authors.lastname: Kinase
authors.forename: Akram
authors.initials: A
authors.lastname: Mohammadi
authors.forename: Masa
authors.initials: M
authors.lastname: Takahashi
authors.forename: Kimiaki
authors.initials: K
authors.lastname: Saito
authors.forename: Maria
authors.initials: M
authors.lastname: Zankl
authors.forename: Richard
authors.initials: R
authors.lastname: Kramer
mesh_terms: D000328:Adult; D000818:Animals; D001001:Anura; D002648:Child; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D051379:Mice; D008954:Models, Biological; D009010:Monte Carlo Method; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation*; D014915:Whole-Body Counting