title: Palladium-catalyzed C-H perfluoroalkylation of arenes.
abstract: A new Pd-catalyzed reaction for the coupling between perfluoroalkyl iodides (R(F)I) and simple aromatic substrates is described. The perfluoroalkylated arene products are obtained in good to excellent yields in the presence of a phosphine-ligated Pd catalyst and Cs(2)CO(3) as a base. The development, optimization, scope, and preliminary mechanistic studies of these transformations are reported.
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
authors.forename: Rebecca N
authors.initials: RN
authors.lastname: Loy
authors.forename: Melanie S
authors.initials: MS
authors.lastname: Sanford
mesh_terms: D000478:Alkylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry
chemical_list: D006847:Hydrocarbons, Iodinated; D010720:Phosphines; D010165:Palladium; C044646:phosphine