title: Isoniazid-induced pellagra.
abstract: Pellagra is characterized by dermatitis, diarrhea, dementia and eventually death occurring as a result of niacin or its precursor tryptophan deficiency. Although pellagra is a well-known complication of isoniazid (INH) therapy, the clinical diagnosis may be missed or delayed that may cause life-threatening consequences. Due to the diversity of pellagra-related signs and symptoms, the diagnosis can be made with an appropriate index of suspicion. We report a 7-year-old boy presenting with INH-induced pellagra that resolved after the administration of the niacin therapy.
authors.affiliation: Yuzuncu yil University, Faculty of Medicine, Department of Dermatology, Van, Turkey. drserapgunes@yahoo.com
authors.forename: Serap Gunes
authors.initials: SG
authors.lastname: Bilgili
authors.forename: Ayse Serap
authors.initials: AS
authors.lastname: Karadag
authors.forename: Omer
authors.initials: O
authors.lastname: Calka
authors.forename: Faruk
authors.initials: F
authors.lastname: Altun
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009536:Niacinamide / Q000008:administration & dosage / Q000627:therapeutic use; D010383:Pellagra / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000995:Antitubercular Agents; D014803:Vitamin B Complex; D009536:Niacinamide; D007538:Isoniazid