title: The reduction of the metabolyc syndrome in Navarra-Spain (RESMENA-S) study: a multidisciplinary strategy based on chrononutrition and nutritional education, together with dietetic and psychological control.
abstract: BACKGROUND
  The high prevalence of metabolic syndrome (MS) in Spain requires additional efforts for prevention and treatment.
  
  
  OBJECTIVE
  The study RESMENA-S aims to improve clinical criteria and biomarkers associated with MS though an integral therapy approach.
  
  
  METHODS
  The study is a randomized prospective parallel design in which is expected to participate a total of 100 individuals. The RESMENA-S group (n = 50) is a personalized weight loss (30% energy restriction) diet, with a macronutrient distribution (carbohydrate / fat / protein) of 40/30/30, high meal frequency (7 / day), low glycemic index/load and high antioxidant capacity as well as a high adherence to the Mediterranean diet. The control group (n = 50) is assigned to a diet with the same energy restriction and based on the American Heart Association pattern. Both experimental groups are under dietary and psychological control during 8 weeks. Likewise, for an additional period of 16 weeks of self-control, is expected that volunteers will follow the same pattern but with no dietary advice.
  
  
  RESULTS
  Anthropometrical data and body composition determinations as well as blood and urine samples are being collected at the beginning and end of each phase. This project is registered at www.clinicaltrials.gov with the number NCT01087086 and count with the Research Ethics Committee of the University of Navarra approval (065/2009).
  
  
  CONCLUSIONS
  Intervention trials to promote the adoption of dietary patterns and healthy lifestyle are of great importance to identify the outcomes and nutritional mechanisms that might explain the link between obesity, metabolic syndrome and associated complications.
authors.affiliation: Department of Nutrition, Food Sciences, Physiology & Toxicology, University of Navarra, Pamplona, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Zulet
authors.forename: I
authors.initials: I
authors.lastname: Bondia-Pons
authors.forename: I
authors.initials: I
authors.lastname: Abete
authors.forename: R
authors.initials: R
authors.lastname: de la Iglesia
authors.forename: P
authors.initials: P
authors.lastname: López-Legarrea
authors.forename: L
authors.initials: L
authors.lastname: Forga
authors.forename: S
authors.initials: S
authors.lastname: Navas-Carretero
authors.forename: J A
authors.initials: JA
authors.lastname: Martínez
mesh_terms: D000328:Adult; D015415:Biomarkers; D001823:Body Composition; D031204:Caloric Restriction; D003376:Counseling; D004032:Diet; D038441:Diet, Mediterranean; D005260:Female; D006266:Health Education; D006801:Humans; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000517:prevention & control* / Q000523:psychology; D009747:Nutritional Physiological Phenomena; D010348:Patient Care Team; D011446:Prospective Studies; D012107:Research Design; D013030:Spain / Q000453:epidemiology; D015431:Weight Loss
chemical_list: D015415:Biomarkers