title: Antiinflammatory sesquiterpenes from the root oil of Ferula hermonis.
abstract: Ferula hermonis Boiss. (Apiaceae), commonly known as 'Shilsh-el-zallouh', 'Hashishat-al-kattira' or 'The Lebanese viagra', is a small shrub that grows abundantly on the Hermon Mountain between Syria and Lebanon. The seeds and roots of this plant have long been used in the Middle East as an aphrodisiac, and for the treatment of frigidity and impotence for both men and women. The antiinflammatory properties of three major daucane esters, ferutinin (1) teferin (2) and teferidin (3), isolated from the root oil of Ferula hermonis, were assessed by the carrageenan-induced oedema model in rats. The antiinflammatory effect of both 1 and 2 was observed with a dose of 100 mg/kg, while compound 3 did not show any antiinflammatory activity; conversely it produced a significant proinflammatory effect 2 and 3 h after carrageenan injection.
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, El-Fateh University, Tripoli, Libya.
authors.forename: Afaf
authors.initials: A
authors.lastname: Geroushi
authors.forename: Abdurazag A
authors.initials: AA
authors.lastname: Auzi
authors.forename: Abdalla Salem
authors.initials: AS
authors.lastname: Elhwuegi
authors.forename: Fawzi
authors.initials: F
authors.lastname: Elzawam
authors.forename: Akram
authors.initials: A
authors.lastname: Elsherif
authors.forename: Lutfun
authors.initials: L
authors.lastname: Nahar
authors.forename: Satyajit D
authors.initials: SD
authors.lastname: Sarker
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001046:Aphrodisiacs / Q000627:therapeutic use; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002351:Carrageenan / Q000633:toxicity; D003508:Cycloheptanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005309:Ferula / Q000737:chemistry*; D005528:Foot; D006801:Humans; D008297:Male; D008877:Middle East; D023421:Models, Animal; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy; D014641:Vanillic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D001046:Aphrodisiacs; D001565:Benzoates; D001643:Bridged Bicyclo Compounds; D003508:Cycloheptanes; D010936:Plant Extracts; D010938:Plant Oils; D012717:Sesquiterpenes; C574822:teferidin; C507392:teferin; C111068:4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en; D002351:Carrageenan; D014641:Vanillic Acid