title: Synthesis, characterization and biological activities of substituted cinnoline culphonamides.
abstract: BACKGROUND
  The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties.
  
  
  METHODS
  In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity.
  
  
  RESULTS
  These derivatives particularly halogen substituted cinnoline derivatives showed potent antimicrobial activity.
  
  
  CONCLUSIONS
  Further investigations are required to find out possible mechanism of action.
authors.affiliation: Indian Veterinary Research Institute, Surgery Division, India. vikasvicky17@rediffmail.com
authors.forename: Saxena
authors.initials: S
authors.lastname: Vikas
authors.forename: S
authors.initials: S
authors.lastname: Darbhamulla
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects*; D001419:Bacteria / Q000187:drug effects*; D052978:Disk Diffusion Antimicrobial Tests; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure
chemical_list: D000890:Anti-Infective Agents; D006574:Heterocyclic Compounds, 2-Ring; C476282:cinnoline