title: Fasting plasma glucose and clustering of cardiometabolic risk factors in normoglycemic outpatient children and adolescents.
abstract: OBJECTIVE
  To evaluate whether fasting plasma glucose (FPG) within a normoglycemic range is associated with cardiometabolic risk factors (CMRF) among children and adolescents in an outpatient setting.
  
  
  METHODS
  Subjects (780; age 6-16 years) with FPG <100 mg/dL were divided into tertiles of FPG.
  
  
  RESULTS
  BMI, waist circumference, homeostasis model assessment-insulin resistance, systolic blood pressure, and white blood cell (WBC) count (P < 0.0001) increased across tertiles of FPG. Subjects with high-normal FPG (89-99 mg/dL) showed a higher risk of insulin resistance, hypertension, and high WBC count compared with subjects with low-normal FPG, independent of BMI z score.
  
  
  CONCLUSIONS
  In outpatient children and adolescents, higher FPG within the normal range is associated with several CMRF, independent of obesity. Thus the simple measurement of FPG may help identify subjects who warrant some monitoring in relation to cardiovascular risk.
authors.affiliation: Department of Internal Medicine, Pozzuoli Hospital, Pozzuoli, Naples, Italy. procolodibonito@alice.it
authors.forename: Procolo
authors.initials: P
authors.lastname: Di Bonito
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sanguigno
authors.forename: Claudia
authors.initials: C
authors.lastname: Forziato
authors.forename: Francesco
authors.initials: F
authors.lastname: Saitta
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Iardino
authors.forename: Brunella
authors.initials: B
authors.lastname: Capaldo
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009765:Obesity / Q000150:complications; D012307:Risk Factors
chemical_list: D001786:Blood Glucose