title: Nutritional surveillance and weight loss in head and neck cancer patients.
abstract: OBJECTIVE
  This retrospective single-institution cohort study aims to evaluate if therapeutic approach, tumour site, tumour stage, BMI, gender, age and civil status predict body weight loss and to establish the association between weight loss on postoperative infections and mortality.
  
  
  METHODS
  Consecutive patients with head and neck cancer were seen for nutritional control at a nurse-led outpatient clinic and followed-up for 2 years after radiotherapy. Demographic, disease-specific and nutrition data were collected from case records. The primary outcome measure was maximum body weight loss during the whole study period.
  
  
  RESULTS
  The nadir of body weight loss was observed 6 months after radiotherapy. In total, 92 patients of 157 (59%) with no evidence of residual tumour after treatment received enteral nutrition. The mean maximum weight loss for patients receiving enteral nutrition and per oral feeding was 13% and 6%, respectively (p < 0.001). Using multivariate analysis, tumour stage (p < 0.001) was the only independent factor of maximum weight loss. Weight loss was not significantly related to risk for postoperative infection.
  
  
  CONCLUSIONS
  Weight loss is frequently noted among head and neck cancer patients during and after treatment. Weight loss was not found to be associated with postoperative infections and mortality. Nutritional surveillance is important in all patients, but special attention should be given to those on enteral nutrition and those with more advanced disease.
authors.affiliation: Department of Clinical Sciences, Intervention and Technology, Division of ENT Diseases, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Ylva.Tiblom.ehrsson@ki.se
authors.forename: Ylva Tiblom
authors.initials: YT
authors.lastname: Ehrsson
authors.forename: Ann
authors.initials: A
authors.lastname: Langius-Eklöf
authors.forename: Göran
authors.initials: G
authors.lastname: Laurell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000554:Ambulatory Care Facilities; D015992:Body Mass Index; D015331:Cohort Studies; D004750:Enteral Nutrition / Q000009:adverse effects / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015596:Nutrition Assessment; D009752:Nutritional Status; D012189:Retrospective Studies; D012307:Risk Factors; D015431:Weight Loss