title: Coexistence of neuroleptic malignant syndrome and a hyperosmolar hyperglycemic state.
abstract: Neuroleptic malignant syndrome (NMS) is a rare idiosyncratic disorder characterized by muscle rigidity, hyperthermia, autonomic dysfunction, and altered consciousness. Although the incidence of NMS is low, it may be fatal if early recognition is delayed. There are a variety of precipitating factors for NMS including systemic illness and dehydration. The combination of NMS with systemic illness can be difficult to diagnose because the systemic illness may mask the coexistence of NMS. We report a patient with hyperosmolar hyperglycemic state with coexistent NMS to remind physicians that hyperosmolar hyperglycemic state may precipitate the development of NMS in patients receiving neuroleptics.
authors.affiliation: Department of Internal Medicine, Hsin Chu General Hospital, School of Medicine, National Yang-Ming University, Hsinchu City 300, Taiwan.
authors.forename: Chung-Wei
authors.initials: CW
authors.lastname: Yang
authors.forename: Ching
authors.initials: C
authors.lastname: Lu
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Wu
authors.forename: Szu-Chi
authors.initials: SC
authors.lastname: Wen
mesh_terms: D000328:Adult; D004636:Emergency Service, Hospital; D017809:Fatal Outcome; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D006944:Hyperglycemic Hyperosmolar Nonketotic Coma / Q000150:complications* / Q000628:therapy; D007328:Insulin / Q000627:therapeutic use; D009459:Neuroleptic Malignant Syndrome / Q000150:complications* / Q000628:therapy
chemical_list: D007328:Insulin