title: Review of a three-year meticillin-resistant Staphylococcus aureus screening programme.
abstract: The Newcastle upon Tyne Hospitals NHS Foundation Trust (NuTH) implemented a seek and destroy (S&D) programme in 2006 to minimise meticillin-resistant Staphylococcus aureus (MRSA) colonisation and/or infection of patients. Using a phased introduction, all patient specialties were included in the scheme by September 2008, well in advance of the mandatory Department of Health, England (DoH) requirement for all patients to be screened. NuTH screens nose, throat and perineum samples from approximately 15,000 patients per month using a chromogenic culture method, showing a mean MRSA prevalence of 2.4%. Provision of seven-day microbiology and infection control services ensured that the turnaround time to prescribing decolonisation therapy was <24 h. Analysis of 168,073 results identified the necessity for inclusion of all three screening sites to maximise recovery of MRSA. Appraisal of the S&D policy demonstrated that MRSA detection rates did not increase despite an exponential increase in workload owing to mandatory inclusion of low risk areas in the screening programme. Review of data during a typical one-month period indicated that only seven day-case patients would not have been identified as MRSA carriers using our targeted S&D approach compared with the DoH universal screening. Detection of these additional patients incurred total laboratory costs of £20,000 and generated a further 4200 associated negative screens in one month alone. Our study indicates that a screening strategy based upon clinical risk is more pragmatic and more cost-effective than the universal programme currently required in England.
authors.affiliation: Department of Microbiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, UK. jennifer.collins@nuth.nhs.uk
authors.forename: J
authors.initials: J
authors.lastname: Collins
authors.forename: M
authors.initials: M
authors.lastname: Raza
authors.forename: M
authors.initials: M
authors.lastname: Ford
authors.forename: L
authors.initials: L
authors.lastname: Hall
authors.forename: S
authors.initials: S
authors.lastname: Brydon
authors.forename: F K
authors.initials: FK
authors.lastname: Gould
mesh_terms: D001431:Bacteriological Techniques; D002353:Carrier State / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D002863:Chromogenic Compounds; D003470:Culture Media; D004739:England; D006784:Hospitals, Teaching; D006801:Humans; D017053:Infection Control / Q000191:economics / Q000379:methods; D008403:Mass Screening / Q000191:economics / Q000379:methods*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D009666:Nose / Q000382:microbiology; D010502:Perineum / Q000382:microbiology; D010614:Pharynx / Q000382:microbiology; D015995:Prevalence; D015397:Program Evaluation; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology
chemical_list: D002863:Chromogenic Compounds; D003470:Culture Media