title: Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats.
abstract: We examined the effect of exercise training (Ex) without (Ex 0%) or with a 3% workload (Ex 3%) on different cardiac and renal parameters in renovascular hypertensive (2K1C) male Fisher rats weighing 150-200 g. Ex was performed for 5 weeks, 1 h/day, 5 days/week. Ex 0% or Ex 3% induced similar attenuation of baseline mean arterial pressure (MAP, 119 ± 5 mmHg in 2K1C Ex 0%, N = 6, and 118 ± 5 mmHg in 2K1C Ex 3%, N = 11, vs 99 ± 4 mmHg in sham sedentary (Sham Sed) controls, N = 10) and heart rate (HR, bpm) (383 ± 13 in 2K1C Ex 0%, N = 6, and 390 ± 14 in 2K1C Ex 3%, N = 11 vs 371 ± 11 in Sham Sed, N = 10,). Ex 0%, but not Ex 3%, improved baroreflex bradycardia (0.26 ± 0.06 ms/mmHg, N = 6, vs 0.09 ± 0.03 ms/mmHg in 2K1C Sed, N = 11). Morphometric evaluation suggested concentric left ventricle hypertrophy in sedentary 2K1C rats. Ex 0% prevented concentric cardiac hypertrophy, increased cardiomyocyte diameter and decreased cardiac vasculature thickness in 2K1C rats. In contrast, in 2K1C, Ex 3% reduced the concentric remodeling and prevented the increase in cardiac vasculature wall thickness, decreased the cardiomyocyte diameter and increased collagen deposition. Renal morphometric analysis showed that Ex 3% induced an increase in vasculature wall thickness and collagen deposition in the left kidney of 2K1C rats. These data suggest that Ex 0% has more beneficial effects than Ex 3% in renovascular hypertensive rats.
authors.affiliation: Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
authors.forename: E R
authors.initials: ER
authors.lastname: Soares
authors.forename: W G
authors.initials: WG
authors.lastname: Lima
authors.forename: R P
authors.initials: RP
authors.lastname: Machado
authors.forename: C M
authors.initials: CM
authors.lastname: Carneiro
authors.forename: M E
authors.initials: ME
authors.lastname: Silva
authors.forename: M C
authors.initials: MC
authors.lastname: Rodrigues
authors.forename: U G
authors.initials: UG
authors.lastname: De Castro
authors.forename: R A S
authors.initials: RA
authors.lastname: Santos
authors.forename: M J
authors.initials: MJ
authors.lastname: Campagnole-Santos
authors.forename: A C
authors.initials: AC
authors.lastname: Alzamora
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001919:Bradycardia / Q000503:physiopathology; D048429:Cell Size; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000517:prevention & control; D007668:Kidney / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000473:pathology; D032383:Myocytes, Cardiac / Q000473:pathology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344