title: Acceptance of two liquid vitamin D₃ formulations among mothers with newborn infants: a randomized, single-blind trial.
abstract: In Switzerland, children are prescribed 7.5-12.5 μg per day of vitamin D(3) dissolved in alcohol, but many families do not adhere to the recommendation. The aim of the trial was to compare the acceptance of vitamin D(3) dissolved in alcohol or in medium-chain triglycerides among mothers of Swiss newborn infants. The acceptance was tested in 42 healthy newborn infants (20 girls and 22 boys) aged between 2 and 7 days. Their neonatal body weight ranged between 2.225 and 4.150 kg, and the gestational age between 36 1/7 and 41 3/7 weeks. The blinded mothers rated the facial reaction of their children by pointing on a facial hedonic scale. Thirty eight of the 41 mothers, who brought the comparison to completion, assigned a better score to the oily preparation with no difference in the remaining three cases (P < 0.0001). The acceptance for the oily preparation was significantly better both among mothers whose babies were initially presented the alcoholic preparation and among mothers whose babies were initially presented the oily preparation. Furthermore, the acceptance for the oily preparation was better irrespective of gender of the infant or parity of the mother. In conclusion, from the perspective of mothers, Swiss newborn infants prefer the taste of the oily vitamin D(3) preparation over the alcoholic preparation.
authors.affiliation: Division of Pediatrics, Bellinzona and Mendrisio and University of Bern, Bern, Switzerland.
authors.forename: Sebastiano A G
authors.initials: SA
authors.lastname: Lava
authors.forename: Giorgio
authors.initials: G
authors.lastname: Caccia
authors.forename: Silvia
authors.initials: S
authors.lastname: Osmetti-Gianini
authors.forename: Giacomo D
authors.initials: GD
authors.lastname: Simonetti
authors.forename: Gregorio P
authors.initials: GP
authors.lastname: Milani
authors.forename: Mattia
authors.initials: M
authors.lastname: Falesi
authors.forename: Mario G
authors.initials: MG
authors.lastname: Bianchetti
mesh_terms: D001835:Body Weight / Q000502:physiology*; D002755:Choice Behavior; D002762:Cholecalciferol / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D041943:Infant Formula; D007231:Infant, Newborn; D008297:Male; D009035:Mothers / Q000523:psychology*; D012189:Retrospective Studies; D016037:Single-Blind Method; D012996:Solutions; D013649:Taste; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D012996:Solutions; D014815:Vitamins; D002762:Cholecalciferol