title: Body mass index and body size in early adulthood and risk of pancreatic cancer in a central European multicenter case-control study.
abstract: The relationship between two measures of excess body weight, body mass index (BMI) and body size score, and risk of pancreatic cancer was examined among 574 pancreatic cancer cases and 596 frequency-matched controls from the Czech Republic and Slovakia enrolled between 2004 and 2009. Analyses using multivariable logistic regression showed an increased risk of pancreatic cancer associated with elevated quartiles of BMI at ages 20 [fourth quartile: odds ratio (OR) = 1.79, 95% confidence interval (CI): 1.23, 2.61] and 40 (fourth quartile: OR = 1.57, 95% CI: 1.09, 2.27) compared to the lowest quartile. Consistent results were observed for body size score at ages 20 (high versus low: OR = 1.66, 95% CI: 1.08, 2.57) and 40 (medium versus low: OR = 1.36, 95% CI: 1.00, 1.86), but no association was found for BMI and body size score at 2 years before the interview. Stronger risk estimates for BMI were observed in males than females, particularly at age 20, but the analysis of body size yielded similar estimates by sex. When considering excess body weight at both ages 20 and 40 jointly, the highest risk estimates were observed among subjects with elevated levels at both time periods in the analysis of BMI (OR = 1.86, 95% CI: 1.32, 2.62) and body size (OR = 1.53, 95% CI: 1.09, 2.13). These findings, based on two different measures, provide strong support for an increased risk of pancreatic cancer associated with excess body weight, possibly strongest during early adulthood.
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Kevin Y
authors.initials: KY
authors.lastname: Urayama
authors.forename: Ivana
authors.initials: I
authors.lastname: Holcatova
authors.forename: Vladimir
authors.initials: V
authors.lastname: Janout
authors.forename: Lenka
authors.initials: L
authors.lastname: Foretova
authors.forename: Eleonora
authors.initials: E
authors.lastname: Fabianova
authors.forename: Zora
authors.initials: Z
authors.lastname: Adamcakova
authors.forename: Miroslav
authors.initials: M
authors.lastname: Ryska
authors.forename: Arnost
authors.initials: A
authors.lastname: Martinek
authors.forename: Olga
authors.initials: O
authors.lastname: Shonova
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Scélo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D049628:Body Size; D001835:Body Weight; D016022:Case-Control Studies; D018153:Czech Republic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D018154:Slovakia; D055815:Young Adult