title: [A case of hypopharyngeal cancer successfully treated with concurrent S-1, nedaplatin and radiotherapy].
abstract: A 68-year-old man was admitted with hoarseness. Laryngofiberscopy showed a tumor that obstructed the posterior hypopharyngeal wall and the larynx, and biopsy revealed well-differentiated squamous cell carcinoma. CT demonstrated bilateral cervical lymph node metastases. The patient was diagnosed as having hypopharyngeal cancer(T4N2cM0)and was treated with concurrent S-1, nedaplatin and radiotherapy(hereafter referred to as SN therapy). CT and endoscopy after primary treatment showed disappearance of the tumor, and the treatment outcome was assessed as complete response(CR). Currently, the patient is being treated with S-1 as adjuvant chemotherapy in the outpatient setting, and no recurrence or metastasis has been observed. These results suggest that SN therapy was effective for advanced hypopharyngeal cancer from the viewpoint of both curative treatment and organ and function preservation.
authors.affiliation: Dept. of Otorhinolaryngology, Showa University, Japan.
authors.forename: Rio
authors.initials: R
authors.lastname: Akiyama
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Shimane
authors.forename: Sei
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Ikeda
authors.forename: Shunya
authors.initials: S
authors.lastname: Egawa
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ikenoya
authors.forename: Aya
authors.initials: A
authors.lastname: Uzuki
authors.forename: Akane
authors.initials: A
authors.lastname: Sugimoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Sanbe
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004338:Drug Combinations; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; D009944:Organoplatinum Compounds; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; C053989:nedaplatin