title: Genomes of two chronological isolates (Helicobacter pylori 2017 and 2018) of the West African Helicobacter pylori strain 908 obtained from a single patient.
abstract: The diverse clinical outcomes of colonization by Helicobacter pylori reflect the need to understand the genomic rearrangements enabling the bacterium to adapt to host niches and exhibit varied colonization/virulence potential. We describe the genome sequences of the two serial isolates, H. pylori 2017 and 2018 (the chronological subclones of H. pylori 908), cultured in 2003 from the antrum and corpus, respectively, of an African patient who suffered from recrudescent duodenal ulcer disease. When compared with the genome of the parent strain, 908 (isolated from the antrum of the same patient in 1994), the genome sequences revealed genomic alterations relevant to virulence optimization or host-specific adaptation.
authors.affiliation: Department of Biotechnology, University of Hyderabad, Gachibowli, Hyderabad, India.
authors.forename: Tiruvayipati Suma
authors.initials: TS
authors.lastname: Avasthi
authors.forename: Singamaneni Haritha
authors.initials: SH
authors.lastname: Devi
authors.forename: Todd D
authors.initials: TD
authors.lastname: Taylor
authors.forename: Narender
authors.initials: N
authors.lastname: Kumar
authors.forename: Ramani
authors.initials: R
authors.lastname: Baddam
authors.forename: Shinji
authors.initials: S
authors.lastname: Kondo
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Hervé
authors.initials: H
authors.lastname: Lamouliatte
authors.forename: Francis
authors.initials: F
authors.lastname: Mégraud
authors.forename: Niyaz
authors.initials: N
authors.lastname: Ahmed
mesh_terms: D000349:Africa; D004269:DNA, Bacterial / Q000737:chemistry* / Q000235:genetics*; D004381:Duodenal Ulcer / Q000382:microbiology; D005753:Gastric Mucosa / Q000382:microbiology; D016680:Genome, Bacterial; D016481:Helicobacter Infections / Q000150:complications / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013270:Stomach / Q000382:microbiology; D037521:Virulence Factors / Q000235:genetics
chemical_list: D004269:DNA, Bacterial; D037521:Virulence Factors