title: High-dose therapy and autologous peripheral blood stem cell transplantation in patients with multiple myeloma.
abstract: Since its introduction in 1983, high-dose therapy followed by autologous peripheral blood stem cell transplantation is a pillar of the treatment of patients with multiple myeloma. In the last decades, a multitude of clinical trials helped to improve strategies based on high-dose therapy and autologous stem cell transplantation resulting in a continuously prolongation of overall survival of patients. In this chapter we will review the progress, which has been made in order to enhance the mobilisation of autologous stem cells and increase the effectiveness of this treatment.
authors.affiliation: Department of Hematology, Heinrich-Heine-University, Düsseldorf, Germany. haas@med.uni-duesseldorf.de
authors.forename: Rainer
authors.initials: R
authors.lastname: Haas
authors.forename: Ingmar
authors.initials: I
authors.lastname: Bruns
authors.forename: Guido
authors.initials: G
authors.lastname: Kobbe
authors.forename: Roland
authors.initials: R
authors.lastname: Fenk
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015815:Cell Adhesion Molecules / Q000502:physiology; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006801:Humans; D020714:Maximum Tolerated Dose; D009101:Multiple Myeloma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D011092:Polyethylene Glycols; D011994:Recombinant Proteins; D014182:Transplantation, Autologous
chemical_list: D000970:Antineoplastic Agents; D015815:Cell Adhesion Molecules; D016298:Hematopoietic Cell Growth Factors; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D003520:Cyclophosphamide; D000069585:Filgrastim