title: Utilization of elderly donors in living donor liver transplantation: when more is less?
abstract: An accepted definition of donor exclusion criteria has not been established for living donor liver transplantation (LDLT). The use of elderly donors to expand the living donor pool raises ethical concerns about donor safety. The aims of this study were (1) the comparison of the postoperative outcomes of living liver donors by age (≥ 50 versus < 50 years) and (2) the evaluation of the impact of the extent of right hepatectomy on donor outcomes. The study group included 150 donors who underwent donor right hepatectomy between October 2004 and April 2009. Extended criteria surgery (ECS) was defined as right hepatectomy with middle hepatic vein (MHV) harvesting or right hepatectomy resulting in an estimated remnant liver volume (RLV) less than 35%. The primary endpoints were donor outcomes in terms of donor complications graded according to the Clavien classification. Group 1 consisted of donors who were 50 years old or older (n = 28), and group 2 consisted of donors who were less than 50 years old (n = 122). At least 1 ECS criterion was present in 74% of donors: 57% had 1 criterion, and 17% had 2 criteria. None of the donors had grade 4 complications or died. The overall and major complication rates were similar in the 2 donor age groups [28.6% and 14.3% in group 1 and 32% and 8.2% in group 2 for the overall complication rates (P = 0.8) and the major complication rates (P = 0.2), respectively]. However, there was a significant correlation between the rate of major complications and the type of surgery in donors who were 50 years old or older. In LDLT, extending the limits of surgery comes at the price of more complications in elderly donors. Right hepatectomy with MHV harvesting and any procedure causing an RLV less than 35% should be avoided in living liver donors who are 50 years old or older.
authors.affiliation: Center for Organ Transplantation, Florence Nightingale Hospital, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Dayangac
authors.forename: C Burcin
authors.initials: CB
authors.lastname: Taner
authors.forename: Onur
authors.initials: O
authors.lastname: Yaprak
authors.forename: Tolga
authors.initials: T
authors.lastname: Demirbas
authors.forename: Deniz
authors.initials: D
authors.lastname: Balci
authors.forename: Cihan
authors.initials: C
authors.lastname: Duran
authors.forename: Yildiray
authors.initials: Y
authors.lastname: Yuzer
authors.forename: Yaman
authors.initials: Y
authors.lastname: Tokat
mesh_terms: D000328:Adult; D000367:Age Factors; D001706:Biopsy; D046148:Donor Selection; D005260:Female; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008099:Liver / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000601:surgery; D011184:Postoperative Period; D020858:Tissue and Organ Harvesting; D009927:Tissue and Organ Procurement / Q000379:methods*; D016896:Treatment Outcome