title: [Oxygen-dependent processes in the blood cells from children with arterial hypertension concomitant with biliary dyskinesia].
abstract: Age individuality is characterized by an imbalance of the molecular mechanisms of antioxidant defense in adolescents with arterial hypertension and biliary dyskinesia, as documented by an enzyme imbalance of the first line of antioxidant defense and H2O, accumulation, by a substantial increase in glutathione peroxidase activity, and by inhibition of the activity of glutathione-dependent enzymes. The considerable rise of 2,3-diphosphoglycerate suggests tissue hypoxia. With this, enhanced neutrophil elastase activity causes damage to the structural components of vascular wall connective tissue, resulting in the development of endothelial dysfunction.
authors.forename: Z I
authors.initials: ZI
authors.lastname: Mikashinovich
authors.forename: G Iu
authors.initials: GIu
authors.lastname: Nagornaia
authors.forename: T D
authors.initials: TD
authors.lastname: Kovalenko
authors.forename: E A
authors.initials: EA
authors.lastname: Zvereva
mesh_terms: D019794:2,3-Diphosphoglycerate / Q000097:blood; D000293:Adolescent; D001657:Biliary Dyskinesia / Q000097:blood* / Q000150:complications; D001773:Blood Cells / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D006973:Hypertension / Q000097:blood* / Q000150:complications; D019272:Leukocyte Elastase / Q000097:blood; D010100:Oxygen / Q000097:blood*
chemical_list: D019794:2,3-Diphosphoglycerate; D006861:Hydrogen Peroxide; D019272:Leukocyte Elastase; D010100:Oxygen