title: Palladium-catalyzed mono-N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol in water.
abstract: Palladium-catalyzed N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol were carried out. The reaction in the presence of Pd(OAc)(2) (5 mol%), sodium diphenylphosphinobenzene-3-sulfonate (TPPMS, 10 mol%), and AcONa (2 equiv) in water at 120 °C for 16 h in a sealed tube gave only mono-N-allylated amino acids in good yield.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan. hidemasa.hikawa@phar.toho-u.ac.jp
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Hikawa
authors.forename: Yuusaku
authors.initials: Y
authors.lastname: Yokoyama
mesh_terms: D000478:Alkylation; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D009942:Organometallic Compounds; D020005:Propanols; D014867:Water; C006463:allyl alcohol; D010165:Palladium