title: Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.
abstract: OBJECTIVE
  The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.
  
  
  METHODS
  One hundred and seventy-two RA patients and 172 controls were enrolled in the study. Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).
  
  
  RESULTS
  IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR: 1.97, 95% CI: 1-3.7, P: 0.035). Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR: 2.6, 95% CI: 1.1-6.1, P: 0.02). The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04).
  
  
  CONCLUSIONS
  IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA.
authors.affiliation: Medical biochemistry department, Faculty of medicine, Zagazig University, Zagazig, Egypt.
authors.forename: Yousri
authors.initials: Y
authors.lastname: Hussein
authors.forename: Shereen
authors.initials: S
authors.lastname: El-Tarhouny
authors.forename: Randa
authors.initials: R
authors.lastname: Mohamed
authors.forename: Heba
authors.initials: H
authors.lastname: Pasha
authors.forename: Amany
authors.initials: A
authors.lastname: Abul-Saoud
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D004247:DNA / Q000032:analysis; D004534:Egypt; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006304:Health Status; D006801:Humans; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012720:Severity of Illness Index
chemical_list: C504000:IL4R protein, human; D053662:Interleukin-4 Receptor alpha Subunit; D004247:DNA