title: Efficacy of low and high fixed dose radioactive iodine therapy in patients with toxic nodular goiter.
abstract: OBJECTIVE
  The efficacy of low and high fixed dose radioactive iodine (RAI) therapy in patients with toxic nodular goiter was investigated.
  
  
  METHODS
  Ninety-three patients (25 males, 68 females) were included into the study (32 patients with toxic adenoma, 61 patients with toxic multinodular goiter). Patients were treated with a fixed dose of 370 MBq (10 mCi) or 740 MBq (20 mCi) RAI. The average follow-up period was 17±10 months.
  
  
  RESULTS
  The overall cure rate (eutyhroidism and hypothyroidism) was 81% in patients treated with 740 MBq RAI and 51% in patients treated with 370 MBq RAI (p<0.05). RAI therapy with a dose of 370 MBq and 740 MBq provided the cure in 73% and 91% of the patients with toxic adenoma and 42% and 76% of the patients with toxic multinodular goiter, respectively. No significant difference for gender was observed. Hypothyroidism developed in 4 and 15 patients with a dose of 370 MBq and 740 MBq RAI, respectively.
  
  
  CONCLUSIONS
  A dose of 740 MBq RAI was found to be more effective for the treatment of toxic nodular goiter as compared to a dose of 370 MBq RAI.
authors.affiliation: Department of Nuclear Medicine, Karadeniz Technical University, School of Medicine, Trabzon, Turkey. sonmezbircan@yahoo.com
authors.forename: B
authors.initials: B
authors.lastname: Sonmez
authors.forename: C
authors.initials: C
authors.lastname: Erem
authors.forename: I
authors.initials: I
authors.lastname: Dogan
authors.forename: H O
authors.initials: HO
authors.lastname: Ersoz
authors.forename: M
authors.initials: M
authors.lastname: Sonmez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006044:Goiter, Nodular / Q000532:radiotherapy*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology / Q000532:radiotherapy; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011874:Radiometry; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes