title: Clinical significance of annexin A2 downregulation in oral squamous cell carcinoma.
abstract: BACKGROUND
  The purpose of this study was to determine the expression of Annexin A2 (ANXA2) in normal oral epithelium and in oral carcinomas to correlate these findings with prognostically relevant variables.
  
  
  METHODS
  ANXA2 expression in normal oral mucosa and in 106 oral squamous cell carcinomas was examined by immunohistochemistry.
  
  
  RESULTS
  ANXA2 expression was detected in basal and suprabasal cell layers of normal epithelium, and immunostaining was preferentially membrane-localized. ANXA2 expression was significantly correlated with the histopathological grade, tumor size, and recurrence, but ANXA2 expression was not an independent prognostic factor.
  
  
  CONCLUSIONS
  The reduction of ANXA2 expression in poorly differentiated tumors is expected to result in a loss of function aimed at the coordination of membrane signaling enzyme complexes. The consequences may manifest as an alteration of epithelial tissue growth and remodeling which eventually exert an influence on tumor progression and metastasis.
authors.affiliation: Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Rodrigo
authors.forename: Paloma
authors.initials: P
authors.lastname: Lequerica-Fernández
authors.forename: Pablo
authors.initials: P
authors.lastname: Rosado
authors.forename: Eva
authors.initials: E
authors.lastname: Allonca
authors.forename: Juana M
authors.initials: JM
authors.lastname: García-Pedrero
authors.forename: Juan C
authors.initials: JC
authors.lastname: de Vicente
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017306:Annexin A2 / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism; D009062:Mouth Neoplasms / Q000378:metabolism*; D011379:Prognosis; D046888:Tissue Array Analysis
chemical_list: D017306:Annexin A2