title: Fluorescent trimethyl-substituted naphthyridine as a ligand for C-C mismatch detection in CCG trinucleotide repeats.
abstract: We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C-C mismatch present in the hairpin structures of (CCG)(n) trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Japan, Sendai 980-8578, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sato
authors.forename: Atsuko
authors.initials: A
authors.lastname: Honjo
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ishikawa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Norio
authors.initials: N
authors.lastname: Teramae
mesh_terms: D020137:Base Pair Mismatch; D001483:Base Sequence; D002244:Carbon / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D008024:Ligands; D009287:Naphthyridines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D018911:Trinucleotide Repeats
chemical_list: C528376:2-amino-5,6,7-trimethyl-1,8-naphthyridine; D005456:Fluorescent Dyes; D008024:Ligands; D009287:Naphthyridines; D002244:Carbon