title: Association between serum adipocyte factor level and insulin resistance in polycystic ovarian syndrome.
abstract: The relationship between serum adipocytokines level and insulin resistance (IR) in polycystic ovary syndrome (PCOS) is unclear. Sixty-one patients with PCOS were divided into an IR group (n = 31) and a non-IR group (n = 30) using homeostasis model assessment (HOMA). Serum levels of luteinizing hormone, follicle-stimulating hormone, estradiol, progesterone, total testosterone, insulin, glucose, and adipocytokines were measured by radioimmunoassay or enzyme-linked immunosorbent assay. The serum adiponectin level in women with PCOS and IR was lower than that of non-IR PCOS patients (P < 0.05); however, there were no significant differences between the two groups with regard to resistin, leptin, and leptin receptor levels (P > 0.05). And the levels of adipocytokines and IR are significantly correlated; consequently, adipocytokines may be involved in the development of IR in PCOS patients.
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Renminnanlu 3duan, Chengdu, 610041, China.
authors.forename: Qiushi
authors.initials: Q
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.forename: Yu
authors.initials: Y
authors.lastname: Tao
authors.forename: Qiuyi
authors.initials: Q
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Song
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D001786:Blood Glucose; D002681:China; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011374:Progesterone / Q000097:blood; D054411:Receptors, Leptin / Q000097:blood; D052243:Resistin / Q000097:blood; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; D020738:Leptin; D054411:Receptors, Leptin; D052243:Resistin; D013739:Testosterone; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone