title: The effects of Agaricus sylvaticus fungi dietary supplementation on the metabolism and blood pressure of patients with colorectal cancer during post surgical phase.
abstract: BACKGROUND
  Metabolic, biochemical and enzymatic alterations are common in patients with cancer. Medicinal fungi has been used as adjuvants in cancer therapy due to its immunomodulatory and nutritional effects.
  
  
  OBJECTIVE
  The objective of this study was to evaluate the metabolic and blood pressure effects on patients with colorectal cancer after dietary supplementation with Agaricus sylvaticus.
  
  
  METHODS
  The methodology used was a randomized, double-blind, placebo-controlled clinical trial conducted at the Base Hospital of the Federal District-Brazil. Samples of 56 patients with colorectal cancer, divided into two groups: Agaricus sylvaticus (30 mg/kg/day) and placebo. Three serum evaluations were conducted throughout the treatment: glucose, total cholesterol, triglycerides, uric acid, urea, creatinine, alkaline phosphatase; total, direct and indirect bilirubin; aspartate aminotransferase and alanine aminotransferase; immunoglobulins A (IgA), G (IgG) and M (IgM); total proteins and protein fractions; blood pressure levels were measured as well. The results were analyzed by Microsoft Excel 2003 and SPSS 14.0 programs, Student's t test, F statistical test, with p < 0.05.
  
  
  RESULTS
  The Agaricus sylvaticus group presented a significant reduction of fasting plasma glucose (p = 0.02), total cholesterol (p = 0.01), creatinine (p = 0.05), aspartate aminotransferase (p = 0.05), alanine aminotransferase (p = 0.04), IgA (p = 0.0001), IgM (p = 0.02), systolic blood pressure (p = 0.0001) and diastolic blood pressure (p = 0.0001). These alterations were not observed in the placebo group.
  
  
  CONCLUSIONS
  Results suggest that dietary supplementation with Agaricus sylvaticus is capable of providing metabolic benefits to the biochemical, enzymatic and blood pressure parameters of patients with colorectal cancer in the postsurgical phase.
authors.affiliation: Science and Education School Sena Aires, University of Brasilia, Brasilia, DF, Brazil. renatacfortes@yahoo.com.br
authors.forename: R
authors.initials: R
authors.lastname: Costa Fortes
authors.forename: M R
authors.initials: MR
authors.lastname: Carvalho Garbi Novaes
mesh_terms: D000328:Adult; D000364:Agaricus / Q000737:chemistry*; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D001938:Brazil; D015179:Colorectal Neoplasms / Q000178:diet therapy* / Q000378:metabolism* / Q000601:surgery; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008019:Life Style; D008055:Lipids / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period
chemical_list: D007136:Immunoglobulins; D008055:Lipids; D005947:Glucose