title: [Inhibitory effect of resveratrol against enterovirus type 71 in vitro].
abstract: OBJECTIVE
  To observe the inhibitory effect of resveratrol against the cytopathogenicity of enterovirus type 71.
  
  
  METHODS
  The cytotoxicity of resveratrol on Vero cells was detected using cell counting kit-8 (CCK-8). The antiviral activity of resveratrol in different stages of infection, with ribavirin as the control, was evaluated by determining the virus inhibition rate, medium effective concentration (IC(50)), and selection index (SI).
  
  
  RESULTS
  Resveratrol was nonpoisonous to Vero cells with an median toxic concentration (TC50) of 307.6 mmol/L. Resveratrol produced an obvious inhibitory effect against enterovirus type 71 only before the cell infection by the virus (IC(50)=20.2 mmol/L , SI=15.2), and once the cells were infected, resveratrol no longer had such antiviral effect.
  
  
  CONCLUSIONS
  Resveratrol may offer some protection against enterovirus type 71 in vitro.
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China. dr.gaolulu@gmail.com
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Gao
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Li
authors.forename: Wen-Chang
authors.initials: WC
authors.lastname: Zhu
authors.forename: Jiang
authors.initials: J
authors.lastname: Guo
authors.forename: Shou-Yi
authors.initials: SY
authors.lastname: Yu
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004770:Enterovirus / Q000187:drug effects*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D013267:Stilbenes; D000077185:Resveratrol