title: Persistent carriage and infection by multidrug-resistant Escherichia coli ST405 producing NDM-1 carbapenemase: report on the first Italian cases.
abstract: We report on the first detection of the NDM-1 carbapenemase in Italy, in Escherichia coli isolated in October 2009. Prolonged colonization and relapsing infection by NDM-1-positive E. coli were observed in a patient (index case) with an indirect epidemiological link with areas of endemicity. Transient colonization was apparently observed in another patient linked with the index case.
authors.affiliation: Section of Microbiology, Department of Biotechnology, University of Siena, and Clinical Microbiology and Virology Unit, Siena University Hospital, 6 53100 Siena, Italy.
authors.forename: Marco Maria
authors.initials: MM
authors.lastname: D'Andrea
authors.forename: Claudia
authors.initials: C
authors.lastname: Venturelli
authors.forename: Tommaso
authors.initials: T
authors.lastname: Giani
authors.forename: Fabio
authors.initials: F
authors.lastname: Arena
authors.forename: Viola
authors.initials: V
authors.lastname: Conte
authors.forename: Paola
authors.initials: P
authors.lastname: Bresciani
authors.forename: Fabio
authors.initials: F
authors.lastname: Rumpianesi
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pantosti
authors.forename: Franco
authors.initials: F
authors.lastname: Narni
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002353:Carrier State / Q000175:diagnosis* / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects* / Q000201:enzymology* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000175:diagnosis* / Q000382:microbiology; D005838:Genotype; D006801:Humans; D007558:Italy; D008826:Microbial Sensitivity Tests; D058889:Molecular Typing; D012008:Recurrence; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1