title: Increased breast density correlates with the proliferation-seeking radiotracer (99m)Tc(V)-DMSA uptake in florid epithelial hyperplasia and in mixed ductal carcinoma in situ with invasive ductal carcinoma but not in pure invasive ductal carcinoma or in mild epithelial hyperplasia.
abstract: The purpose of this study was to assess the relationship of mammographic breast density (BD) and cell proliferation/focal adhesion kinase activation-seeking radiotracer technetium 99m pentavalent dimercaptosuccinic acid (99mTc(V)-DMSA) uptake in women with different breast histologies, that is, mild epithelial hyperplasia (MEH), florid epithelial hyperplasia (FEH), mixed ductal carcinoma in situ with invasive ductal carcinoma (DCIS + IDC), and pure IDC. Fifty-five women with histologically confirmed mammary pathologies were submitted preoperatively to mammography and 99mTc(V)-DMSA scintimammography. The percentage and intensity of 99mTc(V)-DMSA uptake and the percentage of BD were calculated by computer-assisted methods and compared (t-test) between the breast pathologies. In breasts with increased BD, FEH and DCIS + IDC were found. On the contrary, pure IDC and MEH were identified in breasts with significantly lower BD values. In breasts with increased 99mTc(V)-DMSA area and intensity of uptake, FEH was the main lesion found compared to all other histologies. Linear regression analysis between BD and 99mTc(V)-DMSA uptake area and intensity revealed significant coefficients of correlation (r  =  .689, p < .001 and r  =  .582, p < .001, respectively). Increased BD correlates with the presence of FEH and mixed DCIS + IDC but not with pure IDC or MEH. Its close relationship to 99mTc(V)-DMSA, which also showed an affinity to FEH, indicates that stromal microenvironment may constitute a specific substrate leading to progression to different subtypes of cancerous lesions originating from different pathways.
authors.affiliation: Department of Nuclear Medicine, ‘‘Alexandra’’ University Hospital,Athens, Greece. vpapantoniou@gmail.com
authors.forename: Vassilios
authors.initials: V
authors.lastname: Papantoniou
authors.forename: Pipitsa
authors.initials: P
authors.lastname: Valsamaki
authors.forename: Evangelia
authors.initials: E
authors.lastname: Sotiropoulou
authors.forename: Angeliki
authors.initials: A
authors.lastname: Tsaroucha
authors.forename: Spyridon
authors.initials: S
authors.lastname: Tsiouris
authors.forename: Maria
authors.initials: M
authors.lastname: Sotiropoulou
authors.forename: Spyridon
authors.initials: S
authors.lastname: Marinopoulos
authors.forename: Evangelia
authors.initials: E
authors.lastname: Kounadi
authors.forename: Theodore
authors.initials: T
authors.lastname: Karianos
authors.forename: Athina
authors.initials: A
authors.lastname: Fothiadaki
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Archontaki
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Syrgiannis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Ptohis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Makris
authors.forename: Georgios
authors.initials: G
authors.lastname: Limouris
authors.forename: Aris
authors.initials: A
authors.lastname: Antsaklis
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006965:Hyperplasia; D016014:Linear Models; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011877:Radionuclide Imaging; D019783:Technetium Tc 99m Dimercaptosuccinic Acid / Q000493:pharmacokinetics
chemical_list: D019783:Technetium Tc 99m Dimercaptosuccinic Acid