title: Synthesis and immobilization of micro-scale drug particles in cellulosic films.
abstract: The anti-solvent synthesis of micron-scale particles, their stabilization, and subsequent self-assembly into polymer films suitable for drug delivery is presented. The colloidal particles were stabilized using low molecular weight hydroxypropyl methylcellulose (HPMC), while drug encapsulation was carried out with high molecular weight HPMC and polyvinylpyrrolidone (PVP). Griseofulvin (GF) was used as the model drug compound, and the polymer films were evaluated in terms of their surface morphology, mechanical properties and in vitro drug release. In general, the release rates were best described by first-order and Hixson-Crowell kinetic models, and in a typical film containing 57% HPMC, 100% of GF was released within 50 min.
authors.affiliation: Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ 07102, USA.
authors.forename: Xiangxin
authors.initials: X
authors.lastname: Meng
authors.forename: Dachuan
authors.initials: D
authors.lastname: Yang
authors.forename: Golshid
authors.initials: G
authors.lastname: Keyvan
authors.forename: Bozena
authors.initials: B
authors.lastname: Michniak-Kohn
authors.forename: Somenath
authors.initials: S
authors.lastname: Mitra
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D006118:Griseofulvin / Q000737:chemistry; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D011205:Povidone / Q000737:chemistry
chemical_list: D006118:Griseofulvin; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D011205:Povidone