title: [Effect of intervention of granules of eliminating phlegm and removing blood stasis in cochlear morphology of diabetic rats].
abstract: OBJECTIVE
  To study the effectiveness of the granules of eliminating phlegm and removing blood stasis (GEPRB) on glucose metabolism for diabetic rats induced by streptozotocin and that on early diabetic rats cochlear histopathology.
  
  
  METHODS
  Intraperitoneally inject streptozotocin disposable of dose of 55 mg x kg(-1), so that a model of diabetic rats is created, and treated by, and simultaneously treated by Duxil as matched groups for positive, then observe the blood glucose of each group, the histopathology of cochlear, and any circumstantial change of their microstructures.
  
  
  RESULTS
  GEPRB can reduce the cumulating thickness of the basilar membrane and that of the vascular pattern, so as to tighten up the sparsity of the spiral ganglion cells.
  
  
  CONCLUSIONS
  GEPRB is rather effective on hypoglycemic for the diabetic rat model, and therapeutic goal can be achieved by improving the pathological changes of the cochlea damaged. The improvement by GEPRB for microangiopathic change of the cochlea capillary is probably the pathological basis of relieving hearing loss.
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. guo256@yahoo.cn
authors.forename: Hong
authors.initials: H
authors.lastname: Guo
authors.forename: Dajing
authors.initials: D
authors.lastname: Xiong
mesh_terms: D000818:Animals; D003051:Cochlea / Q000033:anatomy & histology / Q000098:blood supply* / Q000187:drug effects; D048909:Diabetes Complications / Q000188:drug therapy*; D004195:Disease Models, Animal; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004427:Ear Diseases / Q000188:drug therapy*; D006801:Humans; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004304:Dosage Forms; D004365:Drugs, Chinese Herbal