title: [Construction and characterisation of a selective membrane electrode for the assay of lisinopril].
abstract: In order to analyze lisinopril using a selective membrane electrode, the electro-active compound was obtained and included in the selective membrane. The new analysis method was developed and validated.
  
  
  METHODS
  The electro-active compound was obtained through the precipitation of lisinopril in acidic media using silicowolframic acid solution. The membrane was obtained by mixing the electro-active compound with polyvinylchloride using tetrahydrofurane as solvent. The solution was evaporated in order to obtain a thick membrane, which was then attached at one end of a polyvinylchloride tube. The internal Ag/AgCl reference electrode was inserted in that tube. The assembly was filled with a lisinopril internal solution. The electrode was characterized by establishing the following characteristics: electrode slope, selectivity, optimal pH range, response time and life-time period. The developed method was validated.
  
  
  RESULTS
  The method showed a good linearity in the range of 10(-7) and 10(-2)M (the correlation coefficient r = 0.9991). The detection limit (LD) was 8,66 x 10(-8)M and the quantification limit (LQ) was 7,8 x 10(-7)M. There were established the precision (RSD = 1.73%) and the accuracy (mean recovery was 99.92%)
  
  
  CONCLUSIONS
  The experimental results demonstrated a good sensibility.
authors.affiliation: Facultatea de Farmacie, Disciplina de Chimie Analitică, Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi.
authors.forename: Mădălina
authors.initials: M
authors.lastname: Vieriu
authors.forename: Nela
authors.initials: N
authors.lastname: Bibire
authors.forename: Gladiola
authors.initials: G
authors.lastname: Tântaru
authors.forename: M
authors.initials: M
authors.lastname: Apostu
authors.forename: Mariana
authors.initials: M
authors.lastname: Mândrescu
authors.forename: V
authors.initials: V
authors.lastname: Dorneanu
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D017736:Ion-Selective Electrodes; D017706:Lisinopril / Q000737:chemistry*; D008567:Membranes, Artificial; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012822:Silicon Dioxide / Q000737:chemistry; D014414:Tungsten / Q000737:chemistry
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D008567:Membranes, Artificial; D012822:Silicon Dioxide; D017706:Lisinopril; D014414:Tungsten