title: [Progress of parathyroid hormone and parathyroid hormone-related protein on normal and osteoarthritis cartilages].
abstract: OBJECTIVE
  To review the progress of mechanism of parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) on normal and osteoarthritis (OA) cartilage and subchondral bones.
  
  
  METHODS
  Recent literature about the effects of PTH and PTHrP on normal and OA cartilage was reviewed.
  
  
  RESULTS
  PTH and PTHrP can repress the hypertrophic differentiation and apoptosis of chondrocytes and promote their proliferation, which has a protection effect on chondrocytes of OA; osteoblasts from subchondral bone of OA show a decreased reaction to PTH.
  
  
  CONCLUSIONS
  PTH and PTHrP may delay and protect the progression of OA, which involves in regulating cartilage degeneration and subchondral bone remodeling through many kinds of signal pathway.
authors.affiliation: Department of Pathology, North Coal Medical College, Tangshan Hebei, 063000, P.R.China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Fu
authors.forename: Wenya
authors.initials: W
authors.lastname: Wang
authors.forename: Liu
authors.initials: L
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis; D002356:Cartilage / Q000166:cytology / Q000473:pathology; D049109:Cell Proliferation; D019902:Chondrocytes / Q000187:drug effects*; D006801:Humans; D010003:Osteoarthritis; D010281:Parathyroid Hormone / Q000494:pharmacology*; D044162:Parathyroid Hormone-Related Protein / Q000494:pharmacology*
chemical_list: D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein