title: Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase.
abstract: The accurate division of duplicated DNA is essential for maintenance of genomic stability in proliferating eukaryotic cells. Errors in DNA replication and chromosomal segregation may lead to cell death or genomic mutations that lead to oncogenic properties. Thus, tight regulation of DNA replication and mitosis is essential for maintaining genomic integrity. Cell division cycle 6 (Cdc6) is an essential factor for initiating DNA replication. Recent work shows that phosphorylation of Cdc6 by polo-like kinase 1 (Plk1), one of the essential mitotic kinases, regulates mitotic exit mediated by Cdk1 and separase. Here we discuss how pre-replicative complex factors are connected with Plk1 and affect mitotic exit.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
authors.forename: Hyungshin
authors.initials: H
authors.lastname: Yim
authors.forename: Raymond L
authors.initials: RL
authors.lastname: Erikson
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D000097869:Polo-Like Kinase 1
chemical_list: D018797:Cell Cycle Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1; C103706:CDC6 protein, human; C083557:p112 protein, rat