title: Strategies for improving the efficacy of bioengineered bone constructs: a perspective.
abstract: Bioengineered bone scaffolds are intended for use in large bone defects. Successful bone constructs should stimulate and support both the onset and the continuance of bone ingrowth. In an attempt to improve their performance and to compete with the one of autologous bone grafts, a growing symbiosis at the biological and material level is required. Recent advances have been made to further exploit the osteogenic potential of MSCs in scaffold development. Current research encompasses new strategies for reducing cell death after implantation and the manufacturing of tailored, instructive scaffolds.
authors.affiliation: Laboratoire de Bioingénierie et Biomatériaux Ostéo-Articulaires-UMR CNRS 7052, 10 Avenue de Verdun, 75010 Paris, France. herve.petite@univ-paris-diderot.fr
authors.forename: H
authors.initials: H
authors.lastname: Petite
authors.forename: K
authors.initials: K
authors.lastname: Vandamme
authors.forename: L
authors.initials: L
authors.lastname: Monfoulet
authors.forename: D
authors.initials: D
authors.lastname: Logeart-Avramoglou
mesh_terms: D017209:Apoptosis; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D018786:Bone Substitutes