title: Role of magnesium sulphate in the treatment of hypomagnesaemia in eclamptic patients.
abstract: Hypomagnasaemia has been identified as one of the main causes of eclampsia and preeclampsia which causes maternal and fetal/neonatal morbidity and mortality. In spite of wide difference of opinion about the best anticonvulsant, magnesium sulphate, diazepam and phenytoin are currently the mostly widely used anticonvulsants. The present study tried to find out the role of MgSO4 in correcting hypomagnasaemia in eclamptic women in Bangladesh. The study included 60 healthy (non eclamptic) 60 eclamptic women and was carried out in two hospitals of Dhaka city, during January 1999 to June 2000. Required tests were done in the Department of Biochemistry, BSMMU. Comparison of pretreatment clinical parameters between the two study groups showed highly significant (p<0.001) differences, MgSO4 level, pulse rate, systolic and diastolic blood pressure, and respiratory rate. After the case group of women was treated with MgSO4, the clinical parameters, pulse rate, systolic and diastolic blood pressure, and respiratory rate, between control and case groups showed no significant differences. However, serum magnesium level in case group increased to 3.41±0.21 mg/dl from pretreatment level of 1.02±0.26 mg/dl, and when compared to control (2.25±0.26 mg/dl), the increase was highly significant (p<0.001). It may be concluded that correction of hypomagnesemia may help to improve eclamptic situation.
authors.affiliation: Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
authors.forename: S A
authors.initials: SA
authors.lastname: Anwary
authors.forename: M
authors.initials: M
authors.lastname: Alfazzaman
authors.forename: M R
authors.initials: MR
authors.lastname: Islam
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D004461:Eclampsia / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008278:Magnesium Sulfate / Q000627:therapeutic use; D011247:Pregnancy
chemical_list: D000927:Anticonvulsants; D008278:Magnesium Sulfate; D008274:Magnesium