title: [Intravitreal bevacizumab treatment for choroidal neovascularization in Best's disease].
abstract: Best's disease is an autosomal-dominant macular dystrophy, which might lead to choroidal neovascularization. The case of a 9-year-old boy followed up for a Best's disease is hereby reported. The boy was referred to our service department for a decrease in visual acuity in his right eye. Ophthalmoscopic examination revealed a foveolar vitelliform lesion, complicated by a choroidal neovascularization. The patient received a single intravitreal bevacizumab injection, which led to a complete resolution of intraretinal fluid and a significant reduction in neovascularization size. Visual acuity also improved. This case underlines the efficiency efficacy of intravitreal anti-VEGF therapy for choroidal neovascularization in Best's disease.
authors.affiliation: Service d'ophtalmologie et de pathologie vitréo-rétinienne, fondation ophtalmologique Adolphe-de-Rothschild, 25, rue Manin, 75019 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Perol
authors.forename: B
authors.initials: B
authors.lastname: Wolff
authors.forename: J-A
authors.initials: JA
authors.lastname: Sahel
authors.forename: Y
authors.initials: Y
authors.lastname: Le Mer
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D002648:Child; D020256:Choroidal Neovascularization / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D005451:Fluorescein Angiography; D005799:Genes, Dominant; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D010375:Pedigree; D011859:Radiography; D012163:Retinal Detachment / Q000209:etiology; D012166:Retinal Hemorrhage / Q000209:etiology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D057826:Vitelliform Macular Dystrophy / Q000150:complications* / Q000235:genetics
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab