title: Idiopathic ulcerative laryngitis.
abstract: OBJECTIVE
  Idiopathic ulcerative laryngitis (IUL) is a distinct, clinical entity that presents after a prolonged upper respiratory infection with cough. It is characterized by the development of bilateral ulcerations of the mid-membranous vocal folds followed by a protracted course of healing. The purpose of this review was to characterize the typical patient presentation, clinical findings, and prognosis.
  
  
  METHODS
  Multi-institutional retrospective review
  
  
  METHODS
  Retrospective review of charts and videostroboscopic exams from patients with IUL at eight institutions.
  
  
  RESULTS
  Fifteen cases met the criteria for IUL and were included in the study. The mean age of the patients was 49 years, and 93% were female. All patients were nonsmokers. Multiple medical interventions were employed by the treating otolaryngologist during the course of the disease, none of which resulted in acute resolution of the ulcerations. The average time from initial presentation to resolution of the disease was 3.3 months. All of the patients reported that their voice was improved after resolution of the disease process. However, in the majority of the patients (60%) there were persistent vibratory abnormalities after resolution of the ulcerations.
  
  
  CONCLUSIONS
  This is the first multi-institutional study to define the complete disease course of IUL and to establish diagnostic criteria. IUL is a rare yet well-recognized clinical entity; however, there is no established etiology for this condition and no definitive treatments have emerged. Further study is needed to establish the etiology/risk factors of this condition and to determine optimal medical management.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The University of Texas Health Science Center, San Antonio, Texas 78229, USA. simpsonc@uthscsa.edu
authors.forename: C Blake
authors.initials: CB
authors.lastname: Simpson
authors.forename: Lucian
authors.initials: L
authors.lastname: Sulica
authors.forename: Gregory N
authors.initials: GN
authors.lastname: Postma
authors.forename: Clark A
authors.initials: CA
authors.lastname: Rosen
authors.forename: Milan R
authors.initials: MR
authors.lastname: Amin
authors.forename: Albert L
authors.initials: AL
authors.lastname: Merati
authors.forename: Mark S
authors.initials: MS
authors.lastname: Courey
authors.forename: Vatsal
authors.initials: V
authors.lastname: Patel
authors.forename: Michael M
authors.initials: MM
authors.lastname: Johns
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007827:Laryngitis / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D012189:Retrospective Studies; D014456:Ulcer / Q000150:complications* / Q000175:diagnosis*