title: Stevens-Johnson syndrome associated with furosemide: a case report.
abstract: OBJECTIVE
  To report a probable association of Stevens-Johnson Syndrome (SJS) with furosemide and suspected cross-sensitivity with lincomycin and silver sulfadiazine cream.
  
  
  CONCLUSIONS
  A 28-year-old Hispanic male was admitted for SJS, with a prolonged hospital course and unclear etiology throughout the majority of the stay. Patient's medications prior to development of SJS symptoms were stable for 3 months and with the exception of furosemide, all were continued throughout the hospitalization while the SJS resolved. During hospitalization, the patient was unintentionally rechallenged with furosemide, after which the rash reappeared and then worsened further with use of silver sulfadiazine cream. At this point in the hospitalization, the prolonged course of the rash prior to admission and the administration of lincomycin 3 days prior to admission were revealed. This suggests the SJS was initially caused by furosemide, a nonaromatic sulfonamide diuretic, with slow progression prior to hospital admission over approximately 7 weeks, followed by an acute worsening caused by lincomycin, a sulfide antibiotic.
  
  
  CONCLUSIONS
  Use of the Naranjo ADR Probability Scale indicates a probable relationship between SJS and furosemide in this patient. Clinicians should be aware of this rare potential adverse effect, even months after the initiation of therapy.
authors.affiliation: University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA.
authors.forename: Amanda A
authors.initials: AA
authors.lastname: Wright
authors.forename: Kimi S
authors.initials: KS
authors.lastname: Vesta
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Stark
authors.forename: Winter J
authors.initials: WJ
authors.lastname: Smith
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D005665:Furosemide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008034:Lincomycin / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D012837:Silver Sulfadiazine / Q000009:adverse effects / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D005665:Furosemide; D008034:Lincomycin; D012837:Silver Sulfadiazine