title: Compatibility of turkey herpesvirus-infectious bursal disease vector vaccine with Marek's disease rispens vaccine injected into day-old pullets.
abstract: Mixtures of turkey herpesvirus (HVT) and Rispens poultry vaccines have been used worldwide for over 20 yr, mainly for vaccination of future layers and breeders. With increasing virulence of Marek's disease (MD) virus strains, vaccination strategies are evolving toward the use of vaccines combining HVT and Rispens. A single vaccination either in ovo or at 1 day of age with the HVT + infectious bursal disease (IBD) vector vaccine is efficient against IBD. However, with vaccination programs that include a hatchery administration of the HVT + IBD vaccine, additional protection against very virulent and very virulent-plus MD viruses is needed, especially for layers and breeders. This study looked at the combination of four commercially available Rispens vaccines with the HVT + IBD vector vaccine injected at 1 day of age. MD challenge tests that were superior to 90% in relative score in all the groups vaccinated with both vaccines showed that the mixture of HVT + IBD and Rispens vaccines had no effect on clinical protection against MD, and IBD challenge tests showed that the mixture of HVT + IBD and Rispens vaccines had no effect on clinical protection against IBD, which was equal to 100% protection in all the groups vaccinated with both vaccines.
authors.affiliation: Merial S.A.S., 29 avenue Tony Garnier, 69348 Lyon CEDEX 07, France. stephane.lemiere@merial.com
authors.forename: Stephane
authors.initials: S
authors.lastname: Lemiere
authors.forename: Siam Yit
authors.initials: SY
authors.lastname: Wong
authors.forename: Anne-lise
authors.initials: AL
authors.lastname: Saint-Gerand
authors.forename: Sylvain
authors.initials: S
authors.lastname: Goutebroze
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Le Gros
mesh_terms: D000818:Animals; D018175:Birnaviridae Infections / Q000517:prevention & control / Q000662:veterinary; D002645:Chickens; D005260:Female; D026002:Herpesvirus 1, Meleagrid / Q000276:immunology*; D007243:Infectious bursal disease virus / Q000276:immunology*; D008380:Marek Disease / Q000517:prevention & control; D022501:Marek Disease Vaccines / Q000276:immunology*; D011201:Poultry Diseases / Q000517:prevention & control*; D013047:Specific Pathogen-Free Organisms
chemical_list: D022501:Marek Disease Vaccines