title: [Adaptation of the cholinergic system of Crenomytilus grayanus (Bivalvia, Mytilidae) to the impact of natural and anthropogenic conditions].
abstract: The effects of environmental conditions on cholinesterase activity and kinetic parameters of substrate hydrolysis in the hemolymph of the mussel Crenomytilus grayanus were studied. Under seasonal upwellings, the cholinergic system efficiency is provided for by a wide range of efficient concentrations of the substrate, i.e., under such conditions the mussels at the molecular level have a quantitative adaptation strategy of the enzyme. In mussels from the stationary upwelling zone (at a steady low temperature of water) for efficiency of the cholinergic system, the quantitative strategy of enzyme adaptation is realized. In mussels from a highly contaminated site, irreversible damages to the cholinergic process were observed. The affinity of the substrate to the enzyme is highly informative and an appropriate biomarker for the load level and the adaptation capacity of the organism. The affinity of the substrate to the enzyme is recommended as a new biomarker.
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Kavun
authors.forename: A I
authors.initials: AI
authors.lastname: Chepkasova
authors.forename: O V
authors.initials: OV
authors.lastname: Podgurskaia
authors.forename: N N
authors.initials: NN
authors.lastname: Kovalev
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D002802:Cholinesterases / Q000378:metabolism*; D006458:Hemolymph / Q000378:metabolism; D019216:Metals, Heavy / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D049879:Mytilidae / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D009792:Oceans and Seas; D012426:Russia; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D019216:Metals, Heavy; D014874:Water Pollutants, Chemical; D002802:Cholinesterases