title: Role of microRNAs in lymphoid biology and disease.
abstract: OBJECTIVE
  This review provides a state-of-the-art knowledge on the implications of microRNA (miRNA) dysregulation in lymphoid malignancies.
  
  
  RESULTS
  Several new studies have broadened our understanding of how aberrations of the miRNome contribute to the development of a malignant lymphoid phenotype. Recently, a new pathogenetic model involving miRNAs and protein coding genes (such as TP53 and ZAP-70) has been identified and explains the prognostic implications of the most recurrent chromosomal abnormalities in human B-cell chronic lymphocytic leukemia. Moreover, new recent studies have addressed the role of miRNAs in human lymphomas and acute lymphoblastic leukemias.
  
  
  CONCLUSIONS
  The recent advances in our understanding of the role of miRNAs in lymphoid malignancies demonstrate that miRNAs can effectively be used as tumoral biomarkers with implications for diagnosis, prognosis, and prediction of response to therapy.
authors.affiliation: Department of Molecular Virology, Immunology and Medical Genetics, the Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA.
authors.forename: Muller
authors.initials: M
authors.lastname: Fabbri
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Croce
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs