title: Two novel biphenyl dimers from the heartwood of Caesalpinia sappan.
abstract: Two novel biphenyl dimers, caesappanin A (1) and B (2), were isolated from the ethanol extract of the heartwood of Caesalpinia sappan. Their structures were elucidated on the basis of spectroscopic data including IR, HRESIMS, 1D and 2D NMR. Preliminary bioassays showed that compound 1 possessed potent cytotoxic effects against 4 cell lines including HCT-8, BGC-823, A549 and A2780 with IC(50) between 1.67μM and 4.88μM.
authors.forename: Shi-Hui
authors.initials: SH
authors.lastname: Shu
authors.forename: An-Jun
authors.initials: AJ
authors.lastname: Deng
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Li
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Qin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001713:Biphenyl Compounds / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D029911:Caesalpinia / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D014934:Wood
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D010936:Plant Extracts; C568430:caesappanin A; C568429:caesappanin B