title: Extraction of fluoxetine from aquatic and urine samples using sodium dodecyl sulfate-coated iron oxide magnetic nanoparticles followed by spectrofluorimetric determination.
abstract: A new method based on the combination of magnetic solid phase extraction (MSPE) and spectrofluorimetric determination was developed for isolation and preconcentration of fluoxetine form aquatic and biological samples using sodium dodecyl sulfate (SDS) coated Fe(3)O(4) nanoparticles (NPs) as a sorbent. The unique properties of Fe(3)O(4) NPs including high surface area and strong magnetism were utilized effectively in the MSPE process. Effect of different parameters influencing the extraction efficiency of fluoxetine including the amount of Fe(3)O(4) and SDS, pH value, sample volume, extraction time, desorption solvent and time were optimized. Under optimized condition, the method was successfully applied to the extraction of fluoxetine from water and urine samples and absolute recovery amount of 85%, detection limit of 20 μg L(-1) and a relative standard deviation (RSD) of 1.4% were obtained. The method linear response was over a range of 50-1000 μg L(-1) with R(2)=0.9968. The relative recovery in different aquatic and urine matrices were investigated and values of 80% to 104% were obtained. The whole procedure showed to be conveniently fast, efficient and economical for extraction of fluoxetine from environmental and biological samples.
authors.affiliation: Environmental and Bio-Analytical Laboratories, Department of Chemistry, Sharif University of Technology, Tehran, Iran. bagheri@sharif.edu
authors.forename: Habib
authors.initials: H
authors.lastname: Bagheri
authors.forename: Omid
authors.initials: O
authors.lastname: Zandi
authors.forename: Ali
authors.initials: A
authors.lastname: Aghakhani
mesh_terms: D005591:Chemical Fractionation / Q000379:methods*; D005473:Fluoxetine / Q000032:analysis* / Q000302:isolation & purification* / Q000652:urine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013501:Surface-Active Agents / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry*
chemical_list: D058185:Magnetite Nanoparticles; D013501:Surface-Active Agents; D005473:Fluoxetine; D014867:Water; D012967:Sodium Dodecyl Sulfate