title: Comparing the digoxin test with the Architect® i1000sr system with respect to the AxSYM® system.
abstract: OBJECTIVE
  To assess the technique employed by the autoanalyser Architect® i1000sr to determine digoxin in serum samples, compared with the assay developed for AsSYM® using microparticle enzyme immunoassay (DigoxinII).
  
  
  METHODS
  A prospective analysis of the samples from 100 requests to monitor patients being treated with digoxin. The samples were processed in AxSYM® and Architect®. The techniques were assessed using the linear regression coefficient, determination coefficient, mean absolute error, mean squared prediction error and the Bland-Altman method.
  
  
  RESULTS
  The serum levels showed a correlation coefficient of 0.93. There was nearly a 40% difference for the concentrations between 0.8 and 2 ng/ml and nearly 20% in the rest of the samples analysed.
  
  
  CONCLUSIONS
  The Architect® system is precise; however, from a clinical monitoring point of view, it is unacceptably inaccurate when compared with the AxSYM®.
authors.affiliation: Servicio de Farmacia, Hospital General de Castellón, Castellón, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Albert Vicent
authors.forename: R
authors.initials: R
authors.lastname: Ferriols Lisart
authors.forename: M A
authors.initials: MA
authors.lastname: Roch Ventura
authors.forename: M
authors.initials: M
authors.lastname: Alós Almiñana
mesh_terms: D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000379:methods; D004077:Digoxin / Q000097:blood*; D006801:Humans; D011446:Prospective Studies
chemical_list: D004077:Digoxin