title: Total synthesis and biological evaluation of marinopyrrole A and analogues.
abstract: A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogues whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037.
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
authors.forename: Nicholas L
authors.initials: NL
authors.lastname: Simmons
authors.forename: Jason S
authors.initials: JS
authors.lastname: Chen
authors.forename: Nina M
authors.initials: NM
authors.lastname: Haste
authors.forename: Victor
authors.initials: V
authors.lastname: Nizet