title: Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation.
abstract: As part of ongoing studies in developing new antimicrobials, we report the synthesis of a new class of structurally novel derivatives, that incorporate two known bioactive structures a thiazole and chalcone, to yield a class of compounds with interesting antimicrobial properties. Evaluation of antibacterial activity showed that almost all the compounds exhibited greater activity than reference drugs and thus could be promising novel drug candidates.
authors.affiliation: Aristotle University, School of Pharmacy, Department of Pharmaceutical Chemistry of Aristotle University of Thessaloniki, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Liaras
authors.forename: A
authors.initials: A
authors.lastname: Geronikaki
authors.forename: J
authors.initials: J
authors.lastname: Glamočlija
authors.forename: A
authors.initials: A
authors.lastname: Cirić
authors.forename: M
authors.initials: M
authors.lastname: Soković
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D047188:Chalcones; D013844:Thiazoles