title: Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism.
abstract: A variable (GT)(n) repeat in the 5'-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subject-control analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 × 10(-4)). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.
authors.affiliation: Laboratoire de Biochimie et Biologie moléculaire, AP-HP, Hôpital Paul Brousse, Université Paris, Inserm U, IFR Villejuif, France.
authors.forename: Marie-Charlotte
authors.initials: MC
authors.lastname: Domart
authors.forename: Amine
authors.initials: A
authors.lastname: Benyamina
authors.forename: Antoinette
authors.initials: A
authors.lastname: Lemoine
authors.forename: Catherine
authors.initials: C
authors.lastname: Bourgain
authors.forename: Lisa
authors.initials: L
authors.lastname: Blecha
authors.forename: Brigitte
authors.initials: B
authors.lastname: Debuire
authors.forename: Michel
authors.initials: M
authors.lastname: Reynaud
authors.forename: Raphaël
authors.initials: R
authors.lastname: Saffroy
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate