title: Protective effect of Woodfordia fruticosa flowers against acetaminophen-induced hepatic toxicity in rats.
abstract: BACKGROUND
  The flowers of Woodfordia fruticosa Kurz. (Lythraceae) are commonly used for the treatment of several ailments which includes rheumatism, leucorrhea, menorrhagia, asthma, liver disorder, and inflammatory conditions.
  
  
  OBJECTIVE
  To evaluate the hepatoprotective property of Woodfordia fruticosa flowers against acetaminophen-induced hepatic injury in rats.
  
  
  METHODS
  Acetaminophen (3 g/kg bw)-induced hepatotoxicity study was carried out by observing the effect of methanol extract of Woodfordia fruticosa flowers (400 and 600 mg/kg, bw) on some serum marker enzymes, albumin, blood urea nitrogen levels as well as liver total protein, nonenzymetic glutathione reduced content, and enzymatic antioxidant glutathione peroxidase, with histopathological evidence.
  
  
  CONCLUSIONS
  Pretreatment of rats with methanol extract of Woodfordia fruticosa flowers effectively prevented the acetaminophen-induced hepatic damage as indicated by the serum marker enzymes aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase and other biochemical parameters (albumin and blood urea nitrogen). Parallel to these changes, the methanol extract of Woodfordia fruticosa flowers also prevented acetaminophen-induced oxidative stress in the rat liver by inhibiting depletion of liver total protein and restoring the levels of nonenzymatic antioxidant glutathione reduced. The biochemical changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the methanol extract of Woodfordia fruticosa flowers.
  
  
  CONCLUSIONS
  The results suggested that methanol extract of Woodfordia fruticosa flowers possesses protective effect against acetaminophen-induced hepatotoxicity.
authors.affiliation: Phytochemical, Pharmacological and Microbiological Laboratory, Department of Biosciences, Saurashtra University, Rajkot-360005, Gujarat, India.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Baravalia
authors.forename: Sumitra
authors.initials: S
authors.lastname: Chanda
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D035264:Flowers / Q000737:chemistry; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D008111:Liver Function Tests; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D011786:Quality Control; D051381:Rats; D017208:Rats, Wistar; D031565:Woodfordia / Q000737:chemistry*
chemical_list: D018712:Analgesics, Non-Narcotic; D000975:Antioxidants; D010936:Plant Extracts; D000082:Acetaminophen