title: [P-selectin gene -2123 polymorphism in children with Henoch-Sch-nlein purpura].
abstract: OBJECTIVE
  To investigate whether P-selectin gene -2123 polymorphism is associated with the pathogenesis of Henoch-Sch-nlein purpura (HSP) in children.
  
  
  METHODS
  Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) is used to identify the distribution of allele and genotype frequencies of P-selectin gene promoter -2123 polymorphism in 86 children with HSP (including 40 cases of purpura nephritis) and 70 healthy controls.
  
  
  RESULTS
  Compared with the healthy controls, the frequencies of GG genotype and G allele of P-selectin promoter -2123 in children with HSP increased significantly (P<0.05). There were no significant differences in P-selectin promoter -2123 genotype and allele frequencies between the patients with and without nephritis.
  
  
  CONCLUSIONS
  P-selectin gene promoter -2123 polymorphism appears to be associated with the pathogenesis of HSP in children.
authors.affiliation: Department of Internal Medicine, Qingdao Medical Care Center for Women and Children, Qingdao, Shandong 266011, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Yi-Bing
authors.initials: YB
authors.lastname: Wang
authors.forename: Hua-Lin
authors.initials: HL
authors.lastname: Liu
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Ya-Qiu
authors.initials: YQ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000209:etiology / Q000235:genetics*; D008297:Male; D019007:P-Selectin / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D019007:P-Selectin