title: Short-term nitrogen dioxide exposure and geomagnetic activity interaction: contribution to emergency hospitalization for acute coronary syndrome.
abstract: We investigated whether extremely geomagnetic activity may modify the association between short-term nitrogen dioxide (NO₂) exposure and emergency hospitalization for acute coronary syndrome (ACS). A case-crossover study design was used to analyze ACS in 6,594 hospitalized patients at the Clinic of Kaunas, Lithuania. We evaluated the associations between NO₂, geomagnetic activity and the rate of emergency admissions for ACS by logistic regression controlling for seasonal variation, weekdays and meteorological factors. Ambient NO₂ pollution interquartile range increase (IQR) on the day of admission and previous day (lag 0-1) in patients below 65 years of age increase the risk of ACS equal to 24% (95% CI 0.96-1.60). Evidence of effect modification by combined NO₂ and geomagnetic activity was observed in relation to ACS, adjusted OR was 1.61; 95% CI 1.03-2.53. In conclusion, these findings suggest that geomagnetic activity variations may increase the traffic-related air pollution effect on ACS, and highlight environmental factors associated with ischemic heart disease course.
authors.affiliation: Vytautas Magnus University, Kaunas, Lithuania. j.vencloviene@gmf.vdu.lt
authors.forename: Jone
authors.initials: J
authors.lastname: Vencloviene
authors.forename: Regina
authors.initials: R
authors.lastname: Grazuleviciene
authors.forename: Ruta
authors.initials: R
authors.lastname: Babarskiene
authors.forename: Audrius
authors.initials: A
authors.lastname: Dedele
authors.forename: Tomas
authors.initials: T
authors.lastname: Grazulevicius
mesh_terms: D054058:Acute Coronary Syndrome / Q000139:chemically induced* / Q000453:epidemiology; D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D002947:Cities / Q000453:epidemiology; D004630:Emergencies; D004781:Environmental Exposure; D005260:Female; D055593:Geological Phenomena; D006760:Hospitalization; D006801:Humans; D008097:Lithuania / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction; D009585:Nitrogen Dioxide / Q000032:analysis / Q000633:toxicity*; D018570:Risk Assessment; D012621:Seasons; D013997:Time Factors; D014887:Weather
chemical_list: D000393:Air Pollutants; D009585:Nitrogen Dioxide