title: Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents.
abstract: A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic molecules inhibit the growth of Staphylococcus aureus, including MRSA and VISA strains, with MIC values ranging from 8 to 16 mg/L.
authors.affiliation: Département de Chimie Moléculaire, UMR, CNRS, Université Joseph Fourier, Grenoble, France. olga.burchak@ujf-grenoble.fr
authors.forename: Olga N
authors.initials: ON
authors.lastname: Burchak
authors.forename: Emmanuelle Le
authors.initials: EL
authors.lastname: Pihive
authors.forename: Laure
authors.initials: L
authors.lastname: Maigre
authors.forename: Xavier
authors.initials: X
authors.lastname: Guinchard
authors.forename: Pascale
authors.initials: P
authors.lastname: Bouhours
authors.forename: Claude
authors.initials: C
authors.lastname: Jolivalt
authors.forename: Dominique
authors.initials: D
authors.lastname: Schneider
authors.forename: Max
authors.initials: M
authors.lastname: Maurin
authors.forename: Carmela
authors.initials: C
authors.lastname: Giglione
authors.forename: Thierry
authors.initials: T
authors.lastname: Meinnel
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Paris
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Denis
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles