title: Fully biodegradable self-rolled polymer tubes: a candidate for tissue engineering scaffolds.
abstract: We report an approach for the fabrication of fully biodegradable self-rolled tubes based on patterned polysuccinimide/polycaprolactone bilayers. These polymers are biocompatible, biodegradable, produced industrially, and are already approved for biomedical purposes. Both polycaprolactone and polysuccinimide are hydrophobic and intrinsically water-insoluble. Polysuccinimide, however, hydrolyzes in physiological buffer environment yielding water-swellable polyaspartic acid that causes the rolling of the polymer bilayer and formation of tubes. We demonstrate the possibility to encapsulate yeast cells using self-rolled tubes.
authors.affiliation: Leibniz Institute of Polymer Research Dresden, Dresden, Germany.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Zakharchenko
authors.forename: Evgeni
authors.initials: E
authors.lastname: Sperling
authors.forename: Leonid
authors.initials: L
authors.lastname: Ionov
mesh_terms: D020341:Absorbable Implants; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000378:metabolism; D002448:Cell Adhesion; D006868:Hydrolysis; D008422:Materials Testing; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011091:Polyesters / Q000138:chemical synthesis* / Q000378:metabolism; D016062:Porosity; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D017155:Wettability; D015003:Yeasts / Q000737:chemistry / Q000166:cytology
chemical_list: D001672:Biocompatible Materials; D010455:Peptides; D011091:Polyesters; C016240:polycaprolactone; C017645:polyaspartate; C025252:poly-DL-succinimide; D001224:Aspartic Acid