title: Ti(O-i-Pr)4/Me3SiCl/Mg-mediated reductive cleavage of sulfonamides and sulfonates to amines and alcohols.
abstract: A low-valent titanium generated in situ from Ti(O-i-Pr)(4), Me(3)SiCl, and Mg powder in THF reacted with aryl- and alkyl-sulfonamides of aryl and alkyl amines in a reductive N-S/S-O/S-C bond cleaving pathway to provide the corresponding amines and hydrocarbons (and thiols) derived from the sulfonyl moiety. The reagent could also cleave sulfonates to the corresponding alcohols.
authors.affiliation: Department of Material and Life Chemistry, Kanagawa University, Kanagawa-ku, Yokohama, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Shohji
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kawaji
authors.forename: Sentaro
authors.initials: S
authors.lastname: Okamoto
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008274:Magnesium / Q000737:chemistry; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000588:Amines; D013438:Sulfhydryl Compounds; D013449:Sulfonamides; D014025:Titanium; D008274:Magnesium