title: Chemoprevention by Triticum Aestivum of mouse skin carcinogenesis induced by DMBA and croton oil - association with oxidative status.
abstract: Chemopreventive action of wheat grass (Triticum astivum) leaf extract in Swiss albino mice was evaluated. Oral administration of wheat grass leaf extract at a dose level of 20 ml/kg body weight per day at pre, peri, and post-initional phases and in combination group, caused significant variation in tumour incidence and tumour yield as compared to the control group. Moreover, the average latent period was significantly increased from 9.87 ± 0.12 to 13.4 ± 0.23 weeks in the combination group, together with significant elevation of reduced glutathione (GSH), superoxide dismutase (SOD) catalase (CAT) and reduction in lipid peroxidation (LPO) was observed as compared to the control group.
authors.affiliation: Cell and Molecular Biology Lab, Centre for Advance Studies, Department of Zoology, University of Rajasthan, Jaipur, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Arya
authors.forename: Madhu
authors.initials: M
authors.lastname: Kumar
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D018890:Chemoprevention / Q000379:methods; D003436:Croton Oil; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012878:Skin Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D014908:Triticum / Q000737:chemistry*
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene; D003436:Croton Oil; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione