title: The effects of linear and cyclic analogs of Locmi-DH, Dippu-DH(46) and Dippu-DH(31) on appetitive behavior in Locusta migratoria.
abstract: The effects of analogs of the diuretic peptides Locmi-DH, Dippu-DH(46) and Dippu-DH(31) on two aspects of appetitive behavior are investigated in previously food-deprived nymphs of Locusta migratoria. The analogs tested are the C-terminal 15-mer and nonapeptides and their corresponding cyclic analogs. At a nominal dose of 1pmol injected per nymph, the linear fragments and their cyclic analogs of Dippu-DH(46) display no significant effects on the latency to feed or on the length of the first meal in nymphs. However, at the same dose, the linear fragments of Dippu-DH(31) and their cyclic analogs, and analogs of Locmi-DH modulate appetitive behavior: they are anorexigenic in reducing the duration of the first meal, and generally increasing the latency to feed. The cyclic analogs of Dippu-DH(31) are at least as effective as their linear counterparts in influencing these aspects of appetitive behavior in locust nymphs.
authors.affiliation: Department of Chemistry, University of Patras, Patras, Greece.
authors.forename: Charoula
authors.initials: C
authors.lastname: Kaskani
authors.forename: Constantine P
authors.initials: CP
authors.lastname: Poulos
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Goldsworthy
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects*; D004232:Diuretics / Q000737:chemistry / Q000494:pharmacology; D007301:Insect Hormones / Q000737:chemistry* / Q000494:pharmacology*; D048188:Locusta migratoria / Q000187:drug effects*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D004232:Diuretics; D007301:Insect Hormones; D010455:Peptides