title: [Breast cancer in diabetic patients].
abstract: Many of the risk factors for postmenopausal breast cancer are related to excess estrogen exposure. Hyperinsulinemia associated with type 2 diabetes mellitus may promote breast cancer via increased peripheral production of estrogens and direct mitogenic effect of insulin itself.
  
  
  METHODS
  Our retro-prospective study compares breast cancer characteristics between two study groups consisting of 53 diabetic and 391 non-diabetic patients diagnosed and treated for breast cancer.
  
  
  RESULTS
  Almost 12% of the patients presenting breast cancer were diabetic and menopause occurred at 48.71 years for diabetic patients and at 49.87 years for the non-diabetic ones. Type 2 diabetes mellitus patients were treated by diet and oral agents, had greater body mass index (32.18 kg/m2), presented well differentiated (57% in G1) but greater (68% in T2) tumors and an increased incidence of lobular (13%) and mixed type (19%) carcinoma.
  
  
  CONCLUSIONS
  Diet and physical exercises as methods for preventing type 2 diabetes mellitus together with screening strategies among diabetic patients could contribute to decreasing the incidence of breast cancer.
authors.affiliation: Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Medicină, Clinica a II(-a) Obstetrică Ginecologie Maternitatea Cuza Vodă Iaşi.
authors.forename: Camelia Cristina
authors.initials: CC
authors.lastname: Cojocaru
authors.forename: Mihaela
authors.initials: M
authors.lastname: Grigore
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Anton
authors.forename: Simona
authors.initials: S
authors.lastname: Muscă
authors.forename: Gh
authors.initials: G
authors.lastname: Costăchescu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D003927:Diet, Diabetic; D015444:Exercise; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D017698:Postmenopause; D012189:Retrospective Studies; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology