title: Mineral homeostasis in children with acute lymphoblastic leukemia before and after chemotherapy.
abstract: A prospective study was carried out in the Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh to evaluate the pattern of mineral changes in children treated for acute lymphoblastic leukemia (ALL) before and after induction chemotherapy. A total number of 32 children aged 1-14 years of both sexes were evaluated. Serum calcium, phosphate, alkaline phosphatase, albumin and creatinine and urinary creatinine and calcium were estimated in cases and control. The mean calcium level at presentation and post induction was 9.50±1.48 mg/dl and 9.08±1.30 mg/dl. Serum phosphate was higher in preinduction mean of 4.83±2.71 mg/dl than post induction value of 4.75±1.38 mg/dl and it was statistically significant. Serum alkaline phosphatase was higher in the post induction period. It was 324.8±128.17 U/L in pre induction and 331.59±93.97 u/l in post induction period. It was not statistically significant. No statistically significant difference was found in pre and post induction urinary calcium and creatinine.
authors.affiliation: Department of Pediatric Hematology and Oncology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh.
authors.forename: C Y
authors.initials: CY
authors.lastname: Jamal
authors.forename: M A
authors.initials: MA
authors.lastname: Karim
authors.forename: M H
authors.initials: MH
authors.lastname: Rahman
authors.forename: S A
authors.initials: SA
authors.lastname: Rahman
authors.forename: M A
authors.initials: MA
authors.lastname: Mannan
mesh_terms: D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006706:Homeostasis; D006801:Humans; D007223:Infant; D008297:Male; D008903:Minerals / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000378:metabolism*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D008903:Minerals; D000469:Alkaline Phosphatase