title: Enhancement of psychotherapy using epigenetic modulating drugs.
abstract: Recent evidence suggests that covalent modifications to the genomic platform in the brain, that is DNA and its surrounding histones, provide a stable potentially lifelong mechanism for remembrance. Consequently, the making and unmaking of memories is accessible through pharmacological manipulations of these modifications. This has implications for psychotherapy and long-term rehabilitation of CNS disorders. We hypothesize that by enhancing learning through pharmacologically manipulating 'epigenetic' parameters, the effects of psychotherapies and rehabilitation can be enhanced.
authors.affiliation: The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA. dgavin@psych.uic.edu
authors.forename: David P
authors.initials: DP
authors.lastname: Gavin
authors.forename: Kayla A
authors.initials: KA
authors.lastname: Chase
authors.forename: Rajiv P
authors.initials: RP
authors.lastname: Sharma
mesh_terms: D002493:Central Nervous System Diseases / Q000523:psychology / Q000628:therapy; D044127:Epigenesis, Genetic / Q000187:drug effects*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006801:Humans; D011613:Psychotherapy
chemical_list: D056572:Histone Deacetylase Inhibitors