title: Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation.
abstract: OBJECTIVE
  The aim of the present study was to determine if micronutrients supplementation can improve neuropathy indices in type 2 diabetes.
  
  
  METHODS
  In this randomized, double-blind, placebo-controlled clinical trial, 75 type 2 diabetes patients were assigned to three treatment groups, receiving one of the following daily supplement for 4 months: Group MV: zinc (20 mg), magnesium (250 mg), vitamin C (200 mg) and E (100 mg); Group MVB: both of the above mineral and vitamin supplements plus vitamin B1 (10 mg), B2 (10 mg), B6 (10 mg), biotin (200 μg), B12 (10 μg) and folic acid (1 mg); Group P: placebo.
  
  
  RESULTS
  67 patients completed the study. Neuropathic symptoms based on the MNSI questionnaire improved from 3.45 to 0.64 (p=0.001) in group MVB, from 3.96 to 1.0 (p=0.001) in group MV and from 2.54 to 1.95 in placebo group after 4 months. There was no significant difference between three treatment groups in MNSI examinations after 4 months supplementations. Over 4 months of treatment, patients showed no significant changes in glycemic control, capillary blood flow or electrophysiological measures in MV and MVB groups compared with placebo group.
  
  
  CONCLUSIONS
  These studies suggest that micronutrients supplementation might ameliorate diabetic neuropathy symptoms.
authors.affiliation: Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. m_farvid@sbmu.ac.ir
authors.forename: Maryam Sadat
authors.initials: MS
authors.lastname: Farvid
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Homayouni
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Amiri
authors.forename: Farhad
authors.initials: F
authors.lastname: Adelmanesh
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy*; D003929:Diabetic Neuropathies / Q000178:diet therapy*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008277:Magnesium Oxide / Q000627:therapeutic use; D008297:Male; D018977:Micronutrients / Q000627:therapeutic use*; D008875:Middle Aged; D014815:Vitamins / Q000627:therapeutic use; D019287:Zinc Sulfate / Q000627:therapeutic use
chemical_list: D018977:Micronutrients; D014815:Vitamins; D008277:Magnesium Oxide; D019287:Zinc Sulfate