title: [Role of PDGF and FGF receptors in cancer].
abstract: Growth factors of the PDGF and FGF families act through receptor tyrosine kinases. These receptors can be activated by chromosomal rearrangements in myeloid neoplasms associated with hypereosinophilia. We identified a new fusion gene between KANK1 and PDGFRbeta in a patient with thrombocythemia. We showed that such fusion oncoproteins derived from PDGF and FGF receptors escape the normal degradation pathways, leading to their accumulation in cells. This process amplifies signalling leading to cell proliferation. Using microarrays and bioinformatics, we showed that several transcription factors contribute to the control cell growth, including STATS, FOXO and SREBP.
authors.affiliation: Institut de Duve, Université catholique de Louvain.
authors.forename: J B
authors.initials: JB
authors.lastname: Demoulin
authors.forename: Sandrine
authors.initials: S
authors.lastname: Medves
authors.forename: Federica
authors.initials: F
authors.lastname: Toffalini
authors.forename: Ahmed
authors.initials: A
authors.lastname: Essaghir
authors.forename: Anders
authors.initials: A
authors.lastname: Kallin
authors.forename: Carmen
authors.initials: C
authors.lastname: Montano
authors.forename: Amélie
authors.initials: A
authors.lastname: Velghe
authors.forename: François
authors.initials: F
authors.lastname: Duhoux
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology*; D017479:Receptors, Platelet-Derived Growth Factor / Q000502:physiology*
chemical_list: D017468:Receptors, Fibroblast Growth Factor; D017479:Receptors, Platelet-Derived Growth Factor