title: Pathological 99mTc-sestamibi myocardial perfusion scintigraphy is independently associated with emerging cardiac events in elderly patients with known or suspected coronary artery disease.
abstract: BACKGROUND
  Only few data are available regarding the prognostic impact of myocardial perfusion scintigraphy with (99m)Tc-sestamibi (MPS) regarding emerging cardiac events in elderly patients
  
  
  OBJECTIVE
  To evaluate the prognostic value of MPS regarding emerging cardiac events in patients aged ≥70 years with known or suspected coronary artery disease (CAD).
  
  
  METHODS
  One hundred and thirty-three patients (74.6 ± 3.7 years) who underwent exercise or pharmacological stress/rest MPS were included in this analysis. Semi-quantitative visual interpretation of MPS images was performed and Summed-Stress- (SSS), Summed-Difference- (SDS), and Summed-Rest Scores (SRS) were calculated. Multivariate logistic regression analyses were calculated for evaluation of the independent prognostic impact of MPS results and several cardiac-related patient characteristics with regard to emerging cardiac events. Kaplan-Meier survival- and log rank analyses were calculated for assessment of cardiac event-free survival.
  
  
  RESULTS
  Pathological SSS (OR: 3.3), angina (OR: 2.7) and ischemic ECG (OR: 3.0) were independently associated with cardiac events. Patients with pathological SSS (p=0.005) and ischemic ECG (p=0.012) had a significantly lower incidence of cardiac event-free survival.
  
  
  CONCLUSIONS
  Pathological MPS is independently associated with emerging cardiac events predicting a significantly lower incidence of cardiac event-free survival in patients aged ≥70 years.
authors.affiliation: Department of Nuclear Medicine, University of Bonn, Germany. jan.bucerius@ukb.uni-bonn.de
authors.forename: Jan
authors.initials: J
authors.lastname: Bucerius
authors.forename: Alexius Y
authors.initials: AY
authors.lastname: Joe
authors.forename: Ellen
authors.initials: E
authors.lastname: Herder
authors.forename: Holger
authors.initials: H
authors.lastname: Brockmann
authors.forename: Kim
authors.initials: K
authors.lastname: Biermann
authors.forename: Holger
authors.initials: H
authors.lastname: Palmedo
authors.forename: Klaus
authors.initials: K
authors.lastname: Tiemann
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Biersack
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D053208:Kaplan-Meier Estimate; D008297:Male; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi