title: [Platelet functions in acute and chronic experimentally induced hepatopathia].
abstract: It's well known the coagulation damage in chronic hepatitis and hepatic cirrhosis. The aim of our study was to quantify platelet dysfunction in acute and chronic toxic hepatitis.
  
  
  METHODS
  We determined adhesivity, aggregability and icosanoids production in rats with acute and chronic hepatopathia induced by CCl4 administration.
  
  
  RESULTS
  Our data shows that platelet adhesivity and aggregability are affected in chronic toxic affectation but also in acute intoxication (p < 0.05). Icosanoids production (expressed like MDA levels are significantly decreased only in chronic CCl4 intoxication (p < 0.001). Significantly correlation appears between aggregability and adhesivity in control group (r = 0.66) and between aggregability and MDA (r = -0.78) and adhesivity and MDA (r = -0.57) in lot C.
  
  
  CONCLUSIONS
  Primary haemostasis and platelet dysfunction are involved in coagulation dysfunction in hepatic diseases and the modifications of platelet parameters also appeared in acute hepatic affectation.
authors.affiliation: Facultatea de Medicină Dentară, Disciplina Patologie Generală, Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi.
authors.forename: Roxana Irina
authors.initials: RI
authors.lastname: Iancu
authors.forename: D
authors.initials: D
authors.lastname: Iancu
authors.forename: Doina
authors.initials: D
authors.lastname: Murărescu
authors.forename: M
authors.initials: M
authors.lastname: Nechifor
authors.forename: M
authors.initials: M
authors.lastname: Costuleanu
mesh_terms: D000208:Acute Disease; D000818:Animals; D001777:Blood Coagulation; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood*; D004195:Disease Models, Animal; D015777:Eicosanoids / Q000097:blood; D006520:Hepatitis, Animal / Q000097:blood*; D006521:Hepatitis, Chronic / Q000097:blood; D008297:Male; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D010976:Platelet Count; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015777:Eicosanoids