title: Serum procarboxypeptidase A and carboxypeptidase A levels in pancreatic disease.
abstract: OBJECTIVE
  To determine the serum levels of procarboxypeptidase A (pro-CPA) and carboxypeptidase A (CPA) in patients with acute and chronic pancreatitis and pancreatic cancer.
  
  
  METHODS
  Serum samples obtained from 96 patients with acute pancreatitis, 101 patients with chronic pancreatitis, 98 patients with pancreatic cancer and 96 control groups were assayed for biochemical parameters and serum pro-CPA and CPA.
  
  
  RESULTS
  Serum pro-CPA and CPA levels were significantly higher in acute and in chronic pancreatic cancer patients compared to control group (p < 0.001). Pancreatic cancer patients had significantly higher serum pro-CPA and CPA levels when compared with acute and chronic pancreatitis cases (p < 0.001).
  
  
  CONCLUSIONS
  These data prove for increased pro-CPA and CPA levels as a biomarker for the diagnosis of pancreatitis and pancreatic cancer.
authors.affiliation: Department of General Surgery, Medical Faculty, University of Yüzüncü Yıl University, Van, Turkey. ozgurkemik@hotmail.com
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kemik
authors.forename: Ahu Sarbay
authors.initials: AS
authors.lastname: Kemik
authors.forename: Aziz
authors.initials: A
authors.lastname: Sumer
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Beğenik
authors.forename: Ahmet Cumhur
authors.initials: AC
authors.lastname: Dülger
authors.forename: Sevim
authors.initials: S
authors.lastname: Purisa
authors.forename: Sefa
authors.initials: S
authors.lastname: Tuzun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043422:Carboxypeptidases A / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000453:epidemiology; D010195:Pancreatitis / Q000097:blood* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D043422:Carboxypeptidases A