title: A hybrid approach to direct pulp capping by using emdogain with a capping material.
abstract: BACKGROUND
  This study evaluated the formation of reparative hard tissues in baboon pulps after Emdogain (EMD) application in conjunction with 3 pulp-capping materials.
  
  
  METHODS
  Thirty-two premolars in four 3-year-old baboons were randomly assigned to 1 of 3 pulp-capping materials. A split-mouth design and intra-animal side randomization were applied to 3 experimental groups (calcium hydroxide, ProRoot White mineral trioxide aggregate, white Portland cement) and the control group (no pulp-capping material). In the hybrid EMD approach, a small drop of EMD was placed over the exposure site after arrest of hemorrhage. The designated pulp-capping material was placed over the EMD, followed by placement of resin-modified glass ionomer cement over the set/unset pulp-capping material. The animals were killed after 4 months. Histomorphometric analysis and micro-computed tomography were performed on the retrieved specimens.
  
  
  RESULTS
  All groups capped with EMD and 1 of the 3 capping materials exhibited similar reparative tissue thickness (P > .05). Dentin tunnel defects were absent in the mineral trioxide aggregate and Portland cement groups after the use of EMD. However, only a tubular was identified from all specimens.
  
  
  CONCLUSIONS
  Mineral trioxide aggregate produces a better quality reparative hard tissue response with the adjunctive use of Emdogain, when compared with the use of calcium hydroxide.
authors.affiliation: College of Dentistry, King Saud University, Riyadh, Saudi Arabia. hezaimik16@gmail.com
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Hezaimi
authors.forename: Badr Abdullah
authors.initials: BA
authors.lastname: Al-Tayar
authors.forename: Yaseer Salim
authors.initials: YS
authors.lastname: Bajuaifer
authors.forename: Ziad
authors.initials: Z
authors.lastname: Salameh
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Fouzan
authors.forename: Franklin R
authors.initials: FR
authors.lastname: Tay
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use; D000818:Animals; D017610:Calcium Compounds / Q000627:therapeutic use; D002126:Calcium Hydroxide / Q000627:therapeutic use; D003723:Dental Amalgam / Q000737:chemistry; D003738:Dental Cements / Q000627:therapeutic use; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D003782:Dental Pulp / Q000187:drug effects; D003785:Dental Pulp Capping / Q000379:methods*; D003789:Dental Pulp Exposure / Q000628:therapy; D003793:Dental Restoration, Permanent; D003804:Dentin / Q000187:drug effects; D003809:Dentin, Secondary / Q000187:drug effects; D004338:Drug Combinations; D005899:Glass Ionomer Cements / Q000737:chemistry; D007091:Image Processing, Computer-Assisted; D010087:Oxides / Q000627:therapeutic use; D010215:Papio; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use*; D011897:Random Allocation; D019279:Resin Cements / Q000737:chemistry; D017640:Silicates / Q000627:therapeutic use; D055114:X-Ray Microtomography
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D003738:Dental Cements; D003746:Dental Enamel Proteins; D004338:Drug Combinations; D005899:Glass Ionomer Cements; D010087:Oxides; D057872:Pulp Capping and Pulpectomy Agents; D019279:Resin Cements; D017640:Silicates; C109069:enamel matrix proteins; C086631:mineral trioxide aggregate; C067790:Vitrabond; D003723:Dental Amalgam; D002126:Calcium Hydroxide