title: Hox transcription factor regulation of adult bone-marrow-derived cell behaviour during tissue repair and regeneration.
abstract: BACKGROUND
  Bone marrow offers a valuable source of stem/progenitor cells that contribute to the repair of injured tissues. Failure in the function of these cells results in delayed or reduced tissue repair. Identification of factors that can correct these defects is critical to treating the underlying dysfunction. Notably, homeobox (Hox) transcription factors have been identified as having significant effects on BMDC behaviour, including differentiation, migration and adhesion in injured tissue, and may provide a basis for future therapies.
  
  
  METHODS
  Hox protein regulation of bone-marrow-derived cell (BMDC) differentiation, factors that influence BMDC behaviour in response to injury, the effects of the diabetic environment on BMDCs, methods that can be used to reprogramme BMDCs, and the use of Hox transcription factors to correct BMDC behaviour.
  
  
  CONCLUSIONS
  Hox gene therapy has been successfully employed to change cell behaviour using ex vivo 'reprogramming' strategies overexpressing selected Hox genes in BMDCs to direct the fate of these cells to the desired cell type, promoting tissue repair.
authors.affiliation: University of Manchester, Healing Foundation Centre, Faculty of Life Sciences, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Elahe
authors.initials: E
authors.lastname: Mahdipour
authors.forename: Kimberly Ann
authors.initials: KA
authors.lastname: Mace
mesh_terms: D000328:Adult; D001854:Bone Marrow Cells / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D012038:Regeneration; D014945:Wound Healing / Q000502:physiology*
chemical_list: D018398:Homeodomain Proteins