title: [Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced ventricular arrhythmias in rats].
abstract: OBJECTIVE
  To investigate the effect of fluvastatin on lysophosphatidylcholine (LPC)-induced ventricular arrhythmias and its mechanism.
  
  
  METHODS
  Twenty male SD rats were randomly allocated into two equal groups, namely LPC treatment group and fluvastatin pretreatment group. Langendorff apparatus was used for cardiac perfusion ex vivo with 5 µmol/L LPC for 5 min followed by washing for 30 min in LPC treatment group, and in fluvastatin pretreatment group, a 30-min perfusion with 10 µmol/L fluvastatin was administered before LPC perfusion. The LPC-induced nonselective cation current (I(NSC)) in the ventricular myocytes was recorded using the whole-cell voltage-clamp method.
  
  
  RESULTS
  Fluvastatin significantly inhibited LPC-induced ventricular tachyarrhythmia/fibrillation and I(NSC). The small G-protein Rho inhibitor (C3) and Rho-kinase inhibitor (Y-27632) in the pipette solution also suppressed LPC-induced I(NSC).
  
  
  CONCLUSIONS
  Fluvastatin offers cardiac protection against LPC by inhibiting LPC-induced I(NSC). LPC induces fatal arrhythmia via a Rho/Rho-kinase-mediated pathway.
authors.affiliation: Department of Cardiovascular Surgery, General Hospital of PLA, Beijing 100853, China. llb03@ tom.com
authors.forename: Li-Bing
authors.initials: LB
authors.lastname: Li
authors.forename: Hong-Ye
authors.initials: HY
authors.lastname: Wang
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Gao
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000378:metabolism; D004336:Drug Antagonism; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D000077340:Fluvastatin; D007211:Indoles / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects; D008244:Lysophosphatidylcholines / Q000009:adverse effects*; D008297:Male; D032383:Myocytes, Cardiac / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D054460:rho-Associated Kinases / Q000378:metabolism
chemical_list: D005229:Fatty Acids, Monounsaturated; D007211:Indoles; D007473:Ion Channels; D008244:Lysophosphatidylcholines; D000077340:Fluvastatin; D054460:rho-Associated Kinases