title: [Clinical features and therapeutics in Hodgkin disease of children].
abstract: OBJECTIVE
  To investigate the incidence and evolution of Hodgkin disease to children under 5 years age.
  
  
  METHODS
  The patients have been investigate to Pediatric Hemato-Oncologic Department from Clinical and Emergencies Hospital for Children "Sf. Maria" Iaşi in a period between January 1980 and December 2004. In this period 129 patients with Hogkin disease have been hospitalised, and among these 48 patients was under 5 years age (37.20%).
  
  
  RESULTS
  From our patients 41 were boys (85.41%) respectively 7 girls (14.59%). Anatomopathologic examination of samples from affected ganglions indicate: 7 patients with lymphocyte prevalence (14.58%), 6 with nodular sclerosis (12.50%), 31 with mixed cellularity (64.58%) and 4 patients with lymphoid depletion (8.34%). Ann-Arbor classification of disease indicate a high incidence of stage II (27 cases--56.25%) in the beginning period than stage I (15 cases--31.25%), III (3 cases--6.25%) and IV (3 cases--6.25%). In 9 cases (18.75%) biochemical syndrome has been observed. Radiotherapy (35 cases--72.91%) and chemotherapy (27.09%) have been used. Failure Free Survival after 5 years for patients with lymphocyte prevalence was 96% for stage I A and II A, 48% for stage III respectively 18% for stage IV. Complications observed were: precocious--medullary toxicity (3 cases), metabolic disorders (4 cases), and late--lung fibrosis with restrictive respiratory dysfunction (2 cases), cardiac dysfunctions (1 case).
authors.affiliation: Centrul Medical Providenţa Iaşi Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Medicină.
authors.forename: Irina
authors.initials: I
authors.lastname: Efrosă
authors.forename: Ingrid
authors.initials: I
authors.lastname: Miron
authors.forename: I
authors.initials: I
authors.lastname: Tansanu
mesh_terms: D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006689:Hodgkin Disease / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D015994:Incidence; D007223:Infant; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D015996:Survival Rate; D016896:Treatment Outcome