title: Hepcidin expression and iron parameters change in Type 2 diabetic patients.
abstract: OBJECTIVE
  Iron may contribute to the pathogenesis of Type 2 diabetes mellitus (DM). The aim of this study was to determine iron regulator hepcidin and iron metabolic parameters in Type 2 DM patients, the relationships among them were evaluated in this specific sub-groups.
  
  
  METHODS
  The study included sixty-four people: 34 cases of diabetes and 30 age-matched controls. Serum hepcidin, IL-6, hsCRP, ferritin, sTfR, EPO as well as other clinical parameters were detected, and the associations between hepcidin levels and iron/inflammatory parameters were analyzed in diabetes and the controls.
  
  
  RESULTS
  Serum ferritin and hepcidin levels in diabetic patients were significant higher than the controls (p<0.001 respectively). A positive correlation between hepcidin and ferritin, as well as between ferritin and IL-6 levels was existed in diabetes and the control groups (p<0.001 respectively).
  
  
  CONCLUSIONS
  All of these data demonstrated that the higher hepcidin levels in diabetic patients may be due to those higher ferritin and IL-6 levels, the elevated hepcidin might have adaptive value through down-regulated iron absorb and play an important role in pathogenesis of Type 2 DM.
authors.affiliation: Department of Hematology Laboratory, The First Affiliated Hospital Of Shantou University Medical College, 57 Changping Road, Shantou, Guangdong 515041, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Jiang
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Sun
authors.forename: Yue-Ting
authors.initials: YT
authors.lastname: Tang
authors.forename: Chuanqing
authors.initials: C
authors.lastname: Xu
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Jiao
mesh_terms: D000368:Aged; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood; D064451:Hepcidins; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D015850:Interleukin-6; D005293:Ferritins; D007501:Iron