title: Chemiluminescence determination of fluoroquinolones using Fenton system in the presence of terbium(iii) ions.
abstract: A simple new chemiluminescent, CL, method is described for the determination of fluoroquinolones such as: ciprofloxacin (CF), norfloxacin (NF), and ofloxacin (OF). This method is based on the measurement of terbium(iii) emission. This emission follows an energy transfer to the uncomplexed terbium(iii) ions from the excited products of fluoroquinolone oxidations. Under optimum conditions, calibration graphs were obtained for 2 × 10(-8)-2 × 10(-6) mol L(-1) of NF; 3 × 10(-8)-2 × 10(-6) mol L(-1) of CF and 4 × 10(-7)-5 × 10(-5) mol L(-1) of OF. The detection limits are 7 × 10(-9) mol L(-1) norfloxacin, 1 × 10(-8) mol L(-1) ciprofloxacin and 1.5 × 10(-7) mol L(-1) ofloxacin. The method was successfully applied to the determination of these drugs in pharmaceutical formulations.
authors.affiliation: Department of Rare Earths, Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kaczmarek
authors.forename: Stefan
authors.initials: S
authors.lastname: Lis
mesh_terms: D002939:Ciprofloxacin / Q000652:urine; D024841:Fluoroquinolones / Q000652:urine*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods*; D009643:Norfloxacin / Q000652:urine; D015242:Ofloxacin / Q000652:urine; D004364:Pharmaceutical Preparations / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods; D013725:Terbium / Q000737:chemistry*
chemical_list: C045076:Fenton's reagent; D024841:Fluoroquinolones; D007477:Ions; D004364:Pharmaceutical Preparations; D013725:Terbium; D002939:Ciprofloxacin; D015242:Ofloxacin; D006861:Hydrogen Peroxide; D007501:Iron; D009643:Norfloxacin