title: Downregulation of CD38 activation markers by atorvastatin in HIV patients with undetectable viral load.
abstract: Immune activation and chronic inflammation are recognized as major component of HIV disease even in patients with undetectable viral load. We evaluated the effect of atorvastatin on CD38 activation in such patients, in a case-control study (133 cases - 266 controls). At week 48, CD38 activation was significantly lower in cases vs. controls, with no difference in high-sensitivity C-reactive protein (hsCRP) and CD4. These results suggest that atorvastatin reduces the level of immune activation in patients with undetectable viral load.
authors.affiliation: Division of Infectious Diseases, Saint-Pierre University Hospital, Brussels, Belgium.
authors.forename: Stéphane
authors.initials: S
authors.lastname: De Wit
authors.forename: Marc
authors.initials: M
authors.lastname: Delforge
authors.forename: Coca Valentina
authors.initials: CV
authors.lastname: Necsoi
authors.forename: Nathan
authors.initials: N
authors.lastname: Clumeck
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000235:genetics / Q000378:metabolism*; D000069059:Atorvastatin; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015536:Down-Regulation; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006538:Heptanoic Acids / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D011758:Pyrroles / Q000494:pharmacology*; D019562:Viral Load
chemical_list: D006538:Heptanoic Acids; D008562:Membrane Glycoproteins; D011758:Pyrroles; D000069059:Atorvastatin; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1