title: Anaesthetic and postanaesthetic effect of isoflurane on the multiple-unit activity of the immature rat hippocampus.
abstract: We investigated anesthetic and postanaesthetic effect of isoflurane on the multi-unit activity (MUA) in the CA3 region of immature rat hippocampus. MUA amplitude did not significantly change during application of isoflurane. On the other hand MUA frequency significantly decreased during the anesthesia. After isoflurane discontinuation two phases of MUA frequency recovery were observed: initial rapid increase followed by a slower recovery to the control level. Comparison of recovering period of the receptor mediated systems and spontaneous field activity from isoflurane anesthesia is discussed.
authors.affiliation: O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv. olena.isaeva@biph.kiev.ua
authors.forename: E V
authors.initials: EV
authors.lastname: Isaeva
authors.forename: D S
authors.initials: DS
authors.lastname: Isaev
mesh_terms: D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000758:Anesthesia; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D056654:CA3 Region, Hippocampal / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D066298:In Vitro Techniques; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014835:Volatilization
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane