title: Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.
abstract: Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.
authors.affiliation: M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Linda
authors.initials: L
authors.lastname: Ejim
authors.forename: Maya A
authors.initials: MA
authors.lastname: Farha
authors.forename: Shannon B
authors.initials: SB
authors.lastname: Falconer
authors.forename: Jan
authors.initials: J
authors.lastname: Wildenhain
authors.forename: Brian K
authors.initials: BK
authors.lastname: Coombes
authors.forename: Mike
authors.initials: M
authors.lastname: Tyers
authors.forename: Eric D
authors.initials: ED
authors.lastname: Brown
authors.forename: Gerard D
authors.initials: GD
authors.lastname: Wright
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000379:methods*; D008911:Minocycline / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline