title: The effect of metoprolol alone and combined metoprolol-felodipin on the digital microcirculation of patients with primary Raynaud's syndrome.
abstract: OBJECTIVE
  Calcium channel inhibitors have beneficial impact on microcirculation, but beta-blocker effect is controversial. Clinicians still do not agree on beta-blocker combination with other treatments in the management of impaired microcirculation. The aim of the present study was to describe the effects of beta-blocker metoprolol monotherapy and combined with calcium channel inhibitor felodipin on digital microcirculation in primary Raynaud's syndrome.
  
  
  METHODS
  We enrolled in this study 46 patients suffering from both hypertension and primary Raynaud's syndrome. Fifteen patients were treated with beta-blocker monotherapy (metoprolol), 13 received combined beta-blocker and calcium channel blocker therapy (felodipin and metoprolol), while 18 patients without any medications served as controls. Measurement of digital microcirculation was carried out with laser Doppler scanner.
  
  
  CONCLUSIONS
  Our investigation concludes that the concurrent administration of beta-blockers with calcium channel inhibitors positively reduces symptoms in patients suffering from Raynaud's syndrome.
authors.affiliation: Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary. csikiz@gmail.com
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Csiki
authors.forename: Ildiko
authors.initials: I
authors.lastname: Garai
authors.forename: Amir H
authors.initials: AH
authors.lastname: Shemirani
authors.forename: Gabor
authors.initials: G
authors.lastname: Papp
authors.forename: Katalin S
authors.initials: KS
authors.lastname: Zsori
authors.forename: Csilla
authors.initials: C
authors.lastname: Andras
authors.forename: Margit
authors.initials: M
authors.lastname: Zeher
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination / Q000379:methods; D015736:Felodipine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry; D008790:Metoprolol / Q000494:pharmacology / Q000627:therapeutic use*; D008833:Microcirculation / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D011928:Raynaud Disease / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D008790:Metoprolol; D015736:Felodipine