title: Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan.
abstract: The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z ≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ~250-330 nm and zeta potential (ζ) ranging from ~+80 to +7 mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.
authors.affiliation: CIAD - Guaymas, Carret. al Varadero Nac. Km 6.6, Guaymas, Sonora 85480, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Rosas-Durazo
authors.forename: J
authors.initials: J
authors.lastname: Lizardi
authors.forename: I
authors.initials: I
authors.lastname: Higuera-Ciapara
authors.forename: W
authors.initials: W
authors.lastname: Argüelles-Monal
authors.forename: F M
authors.initials: FM
authors.lastname: Goycoolea
mesh_terms: D002351:Carrageenan / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*
chemical_list: D053769:Nanocapsules; D000644:Quaternary Ammonium Compounds; D002351:Carrageenan; C022806:dodecyltrimethylammonium