title: Transition from acenocoumarol to warfarin in a 12-year-old child.
abstract: The types of coumadin anticoagulants registered and available for use differ between countries. Most frequently used coumadin anticoagulants are warfarin and acenocoumarol. Under several specific conditions, transition from one coumarin to another is required. Because of different pharmacokinetic and pharmacodynamic characteristics, the transition from one type of coumarol to another type can be challenging. There are no studies that address this issue in children. We present the case report of transition treatment between acenocoumarol and warfarin in a 12-year-old child with prosthetic mitral valve.
authors.affiliation: Department of Pediatric Cardiology, Children's Heart Center, Skane University Hospital, Lund, Sweden. nina.hakacova@gmail.com
authors.forename: Nina
authors.initials: N
authors.lastname: Hakacova
authors.forename: Gudrun
authors.initials: G
authors.lastname: Björkhem
authors.forename: Katarina
authors.initials: K
authors.lastname: Hanséus
mesh_terms: D000074:Acenocoumarol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000925:Anticoagulants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001777:Blood Coagulation / Q000187:drug effects*; D002648:Child; D016903:Drug Monitoring / Q000379:methods; D057915:Drug Substitution; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006801:Humans; D019934:International Normalized Ratio; D008943:Mitral Valve / Q000601:surgery*; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome; D014859:Warfarin / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D000074:Acenocoumarol