title: [Autoantibodies to α7-subunit of neuronal acetylcholine receptor in children with traumatic brain injury].
abstract: An objective of the study was to search for new biologically significant markers of brain damage. Levels of blood serum autoantibodies (aAB) to different fragments of α7-subunit of acetylcholine receptor (ACR) were studied in children with traumatic brain injury of different severity. The more severe was trauma, the higher was the level of aAB to fragments of α7-subunit of ACR in the first week after trauma. The data obtained suggest that α7-subunits of ACR and aAB to them are involved in the pathogenesis of traumatic brain lesions and, probably, play a significant role in the course of post traumatic period.
authors.forename: E G
authors.initials: EG
authors.lastname: Sorokina
authors.forename: O M
authors.initials: OM
authors.lastname: Vol'pina
authors.forename: Zh B
authors.initials: ZhB
authors.lastname: Semenova
authors.forename: O V
authors.initials: OV
authors.lastname: Karaseva
authors.forename: D O
authors.initials: DO
authors.lastname: Koroev
authors.forename: A V
authors.initials: AV
authors.lastname: Kamynina
authors.forename: V P
authors.initials: VP
authors.lastname: Reutov
authors.forename: M A
authors.initials: MA
authors.lastname: Salykina
authors.forename: A V
authors.initials: AV
authors.lastname: Panova
authors.forename: A V
authors.initials: AV
authors.lastname: Goriunova
authors.forename: V G
authors.initials: VG
authors.lastname: Pinelis
authors.forename: L M
authors.initials: LM
authors.lastname: Roshal'
mesh_terms: D000595:Amino Acid Sequence; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D023261:Glasgow Outcome Scale; D006801:Humans; D008969:Molecular Sequence Data; D011978:Receptors, Nicotinic / Q000276:immunology*; D064569:alpha7 Nicotinic Acetylcholine Receptor
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; C579167:Chrna7 protein, human; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor