title: Potential tumor-tropic effect of genetically engineered stem cells expressing suicide enzymes to selectively target invasive cancer in animal models.
abstract: Stem cells have recently received a great deal of attention for their clinical and therapeutic potential to treat human disease and disorders. For instance, neural stem cells expressing a suicide gene which can concert prodrugs to their active metabolites may have great tropic and therapeutic potential for brain tumors, i.e., medulloblastoma and glioma. We are currently interested in therapeutic potential of these genetically engineered stem cells (GESTECs) to selectively target invasive tumors, i.e. ovarian, endometrial, breast, and lung cancer which can have a great impact on human and animal health. Thus, in this review we summarize the therapeutic potential of GESTEC, developed by us, and the putative mechanism(s) underlying their therapeutic and tropic potential in expressing suicide genes which can convert prodrugs to their active metabolites and in selectively targeting invasive tumors.
authors.affiliation: Department of Medicine, University of British Columbia Hospital Vancouver, BC, Canada.
authors.forename: Seung U
authors.initials: SU
authors.lastname: Kim
authors.forename: Eui-Bae
authors.initials: EB
authors.lastname: Jeung
authors.forename: Yun-Bae
authors.initials: YB
authors.lastname: Kim
authors.forename: Myung-Haing
authors.initials: MH
authors.lastname: Cho
authors.forename: Kyung-Chul
authors.initials: KC
authors.lastname: Choi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D041722:Genes, Transgenic, Suicide; D005818:Genetic Engineering; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009361:Neoplasm Invasiveness; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000473:pathology* / Q000628:therapy*; D013234:Stem Cells / Q000502:physiology*