title: Regioselective hydroformylation of allylic alcohols.
abstract: A highly regioselective hydroformylation of allylic alcohols is reported toward the synthesis of β-hydroxy-acid and aldehyde products. The selectivity is achieved through the use of a ligand that reversibly binds to alcohols in situ, allowing for a directed hydroformylation to occur. The application to trisubstituted olefins was also demonstrated, which yields a single diastereomer product consistent with a stereospecific addition of CO and hydrogen.
authors.affiliation: Boston College, Merkert Chemistry Center, Chestnut Hill, Massachusetts 02467-3860, United States.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Lightburn
authors.forename: Omar A
authors.initials: OA
authors.lastname: De Paolis
authors.forename: Ka H
authors.initials: KH
authors.lastname: Cheng
authors.forename: Kian L
authors.initials: KL
authors.lastname: Tan
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000447:Aldehydes; D000475:Alkenes; D020005:Propanols; C006463:allyl alcohol