title: The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring.
abstract: OBJECTIVE
  To describe the interrelationships of glycemic control measures: hemoglobin A1c (HbA1c), glycated albumin, fructosamine, 1,5-anhydroglucitrol (1,5-AG), and continuous glucose monitoring (CGM) in children and adolescents with type 1 diabetes.
  
  
  METHODS
  In total, 26 subjects of age 4-17 had HbA1c measurement followed within 14 d by three laboratory measures of glycemia and the collection of CGM glucose data (N = 21).
  
  
  RESULTS
  Glycated albumin and fructosamine levels had a higher correlation with each other than with HbA1c. The correlation of 1,5-AG with HbA1c was lower (absolute r value = 0.25). All four measures had a similar degree of correlation with CGM-measured mean glucose (absolute r value = 0.50-0.56) and with hyperglycemic area under the curve (AUC) at 180 mg/dL (0.50-0.60).
  
  
  CONCLUSIONS
  Each of the four measures (i.e., HbA1c, glycated albumin, fructosamine, and 1,5-AG) had a similar correlation with mean glucose and hyperglycemic AUC-180. 1,5-AG did not correlate with hyperglycemic AUC-180 better than did HbA1c.
authors.affiliation: Jaeb Center for Health Research, Tampa, FL 33647, USA. rbeck@jaeb.org
authors.forename: Roy
authors.initials: R
authors.lastname: Beck
authors.forename: Michael
authors.initials: M
authors.lastname: Steffes
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Xing
authors.forename: Katrina
authors.initials: K
authors.lastname: Ruedy
authors.forename: Nelly
authors.initials: N
authors.lastname: Mauras
authors.forename: Darrell M
authors.initials: DM
authors.lastname: Wilson
authors.forename: Craig
authors.initials: C
authors.lastname: Kollman
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D015190:Blood Glucose Self-Monitoring; D002648:Child; D002675:Child, Preschool; D003847:Deoxyglucose / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D019270:Fructosamine / Q000097:blood*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D017127:Glycation End Products, Advanced; D006801:Humans; D008297:Male; D012709:Serum Albumin / Q000378:metabolism*; D000093423:Glycated Serum Albumin
chemical_list: D001786:Blood Glucose; D003847:Deoxyglucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin; C006584:1,5-anhydroglucitol