title: Is balloon aortic valvuloplasty safe in patients with significant aortic valve regurgitation?
abstract: OBJECTIVE
  To assess safety and effectiveness of balloon aortic valvuloplasty (BAV) in patients with symptomatic severe aortic stenosis (AS) and significant aortic regurgitation.
  
  
  BACKGROUND
  BAV is a palliative procedure that has possibly been underused in patients with symptomatic AS not suitable for surgical aortic valve replacement or transcatheter aortic valve implantation. Significant aortic regurgitation is commonly perceived as a contraindication to BAV.
  
  
  METHODS
  Among 416 consecutive patients undergoing BAV at our Institution, 73 patients showed moderate or severe AR before the procedure. Demographics and baseline characteristics, as well as in-hospital clinical outcome, have been prospectively collected in a dedicated database. Transthoracic echocardiography was regularly performed in all patients undergoing BAV before the procedure and at hospital discharge.
  
  
  RESULTS
  Patients had a high-risk profile, confirmed by advanced age (77.2 ± 11.8 years) and important comorbidity (logistic Euroscore 26.5 ± 16.3%). Advanced heart failure was present in 73.9%. Indication to BAV was cardiogenic shock in 9.6%, palliation in 31.5%, bridge in 58.9% of the patients. BAV was performed with standard retrograde approach. Aortic valve area increased from 0.62 ± 0.15 cm(2) at baseline to 0.83 ± 0.17 cm(2) before discharge (P < 0.001). The degree of AR was improved or unchanged in 65 patients (89%). In-hospital mortality was 6.9%, mainly limited to terminal patients. Symptomatic status at discharge was improved in all surviving patients. Acute AR occurred in seven patients; in five of them it was successfully resolved in the catheterization laboratory.
  
  
  CONCLUSIONS
  When clinically indicated, BAV can be safely performed in patients with combined aortic stenosis and significant aortic regurgitation.
authors.affiliation: Department of Cardiovascular Diseases, Institute of Cardiology, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy. francescosaia@hotmail.com
authors.forename: Francesco
authors.initials: F
authors.lastname: Saia
authors.forename: Cinzia
authors.initials: C
authors.lastname: Marrozzini
authors.forename: Cristina
authors.initials: C
authors.lastname: Ciuca
authors.forename: Barbara
authors.initials: B
authors.lastname: Bordoni
authors.forename: Gianni
authors.initials: G
authors.lastname: Dall'Ara
authors.forename: Carolina
authors.initials: C
authors.lastname: Moretti
authors.forename: Nevio
authors.initials: N
authors.lastname: Taglieri
authors.forename: Tullio
authors.initials: T
authors.lastname: Palmerini
authors.forename: Angelo
authors.initials: A
authors.lastname: Branzi
authors.forename: Antonio
authors.initials: A
authors.lastname: Marzocchi
mesh_terms: D000368:Aged; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000628:therapy*; D002404:Catheterization / Q000379:methods*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010166:Palliative Care; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome