title: Determinants of the hyperdynamic circulation and central hypovolaemia in cirrhosis.
abstract: BACKGROUND
  Patients with advanced cirrhosis often develop a hyperdynamic circulation with central hypovolaemia. The events that initiate the systemic haemodynamic abnormalities and the coupling of these factors to splanchnic haemodynamics are still unclear. Objective On the basis of a large population of patients with cirrhosis to identify splanchnic and clinical characteristics associated with the development of the hyperdynamic circulation and survival.
  
  
  METHODS
  We included 410 patients with cirrhosis. In all patients, a full haemodynamic investigation was performed. The data were analysed using regression analyses, principal components analyses, and Cox proportional hazards analyses.
  
  
  RESULTS
  Multivariate regression analyses showed that higher cardiac output was independently associated with higher hepatic venous pressure gradient (HVPG) and higher hepatic blood flow (HBF) (p<0.00001). Higher heart rate was independently associated with presence of ascites and higher HVPG (p<0.0001). Central blood volume and circulation time were independently associated with higher HBF and lower postsinusoidal resistance, respectively (p<0.0001). Systemic vascular resistance was independently associated with lower HVPG (p<0.0001). The final Cox proportional hazards model showed that decreased survival was independently associated with higher age (p=0.003), lower blood haemoglobin concentration (p=0.0006), higher plasma creatinine (p=0.01), higher plasma alkaline phosphatase (p=0.007), lower right atrial pressure (p=0.004), and higher heart rate (p=0.002).
  
  
  CONCLUSIONS
  The development of the hyperdynamic circulation and central hypovolaemia are mainly explained by changes in portal pressure and HBF. Together with indicators of liver dysfunction, central hypovolaemia is associated with poorer prognosis.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, 239 Hvidovre Hospital, DK-2650 Hvidovre, Denmark. soeren.moeller@hvh.regionh.dk
authors.forename: Søren
authors.initials: S
authors.lastname: Møller
authors.forename: Lise
authors.initials: L
authors.lastname: Hobolth
authors.forename: Christine
authors.initials: C
authors.lastname: Winkler
authors.forename: Flemming
authors.initials: F
authors.lastname: Bendtsen
authors.forename: Erik
authors.initials: E
authors.lastname: Christensen
mesh_terms: D004812:Epidemiologic Methods; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D020896:Hypovolemia / Q000209:etiology* / Q000503:physiopathology; D008102:Liver Circulation / Q000502:physiology; D008103:Liver Cirrhosis / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017082:Portal Pressure / Q000502:physiology; D011379:Prognosis; D013152:Splanchnic Circulation / Q000502:physiology