title: Oxidative status and its relation with insulin resistance in young non-obese women with polycystic ovary syndrome.
abstract: BACKGROUND
  Oxidative stress may play a role in the pathophysiology of polycystic ovary syndrome (PCOS). Insulin resistance (IR) also can be found in young non-obese women with PCOS. Hyperglycemia may increase reactive oxygen species production and decrease antioxidant levels.
  
  
  OBJECTIVE
  To investigate oxidative status and its relation with IR in young non-obese patients with PCOS.
  
  
  METHODS
  Thirty-one patients with hyperinsulinemic (no.=13) and normoinsulinemic (no.=18) PCOS and 29 healthy controls were included in this study. Serum levels of glucose, insulin, gonadotropins, total testosterone, DHEAS, SHBG, 2-h plasma glucose on oral glucose tolerance test, malondialdehyde (MDA), protein carbonyl (PC), reduced glutathione (GSH), β carotene, vitamin A, C, E and the enzyme activities of catalase and glutathione S-transferase (GST), IR [by homeostasis model assessment (HOMA)-IR], and β cell function [by HOMA-B] were assessed.
  
  
  RESULTS
  Serum glucose, insulin, total testosterone, DHEAS, HOMA-IR levels, and LH/FSH ratios were higher in young non-obese women with PCOS. Serum MDA and PC levels were also higher but GSH, vitamin C and E levels, and GST enzyme activity were lower in these women than in healthy controls, independently of the status of IR (p<0.05).
  
  
  CONCLUSIONS
  Oxidative stress characterized by increased oxidants and decreased antioxidant levels which are independent of IR may be involved in the pathogenesis of PCOS in young non-obese women.
authors.affiliation: Department of Obstetrics and Gynecology, University of Yuzuncu Yil, Van, Turkey. zehrakurdoglu@hotmail.com
authors.forename: Z
authors.initials: Z
authors.lastname: Kurdoglu
authors.forename: H
authors.initials: H
authors.lastname: Ozkol
authors.forename: Y
authors.initials: Y
authors.lastname: Tuluce
authors.forename: I
authors.initials: I
authors.lastname: Koyuncu
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000502:physiology*; D002374:Catalase / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D005978:Glutathione / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006706:Homeostasis / Q000502:physiology; D006728:Hormones / Q000097:blood; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D050050:Protein Carbonylation / Q000502:physiology; D014815:Vitamins / Q000097:blood; D055815:Young Adult; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D006728:Hormones; D014815:Vitamins; D019207:beta Carotene; D008315:Malondialdehyde; D002374:Catalase; D005982:Glutathione Transferase; D005978:Glutathione