title: New bicyclotridecane C15 nonterpenoid bromoallenes from Laurencia marilzae.
abstract: Nonterpenoid bromoallenes possessing a novel skeleton that incorporates an unprecedented [5.5.1]bicyclotridecane ring system, marilzabicycloallenes A-D (1-4), were isolated from specimens of Laurencia marilzae collected on the Canary Islands. The framework of these metabolites strongly reinforces Braddock's hypothesis concerning the biosynthesis via electrophilic bromination of the obtusallene family.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, La Laguna, Spain.
authors.forename: Adrián
authors.initials: A
authors.lastname: Gutiérrez-Cepeda
authors.forename: José J
authors.initials: JJ
authors.lastname: Fernández
authors.forename: Manuel
authors.initials: M
authors.lastname: Norte
authors.forename: María L
authors.initials: ML
authors.lastname: Souto
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004988:Ethers, Cyclic / Q000737:chemistry; D005260:Female; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044722:Laurencia / Q000737:chemistry*; D015394:Molecular Structure; D013030:Spain
chemical_list: D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004988:Ethers, Cyclic; D006842:Hydrocarbons, Brominated; C559359:marilzabicycloallene A; C522877:obtusallene