title: Dengue vaccines: progress and challenges.
abstract: With several dengue vaccine candidates progressing through clinical trials, several options for controlling this disease appear feasible. This would represent a major achievement and reflect decades of research and development activities. The challenges associated with the limited understanding of protective responses and those factors which determine disease severity remain, but with prospective studies ongoing in various dengue endemic areas and the initiation of dengue vaccine efficacy trials, immune responses are being evaluated in the context of protection and severe disease and these studies are highly likely to provide additional insights.
authors.affiliation: Vaccines Research, WP17-2131, Merck and Company, 770 Sumneytown Pike, P.O. Box 4, West Point, PA 19486, United States. beth-ann.coller@merck.com
authors.forename: Beth-Ann G
authors.initials: BA
authors.lastname: Coller
authors.forename: David E
authors.initials: DE
authors.lastname: Clements
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D003715:Dengue / Q000453:epidemiology / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D053059:Dengue Vaccines / Q000276:immunology* / Q000627:therapeutic use; D006801:Humans
chemical_list: D053059:Dengue Vaccines