title: Pregnancy after ovarian superovulation by transdermal delivery of follicle-stimulating hormone.
abstract: Because of its size of 32 kDa and physicochemical properties, urinary FSH cannot permeate intact skin. We report the first pregnancy after laser microporation and transdermal delivery of FSH for ovarian superovulation as a substitute for SC or IM injections.
authors.affiliation: IVF Centers Prof. Zech, Bregenz, Austria. n.zech@ivf.at
authors.forename: Nicolas H
authors.initials: NH
authors.lastname: Zech
authors.forename: Maximilian
authors.initials: M
authors.lastname: Murtinger
authors.forename: Petr
authors.initials: P
authors.lastname: Uher
mesh_terms: D000279:Administration, Cutaneous; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000378:metabolism; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D018587:Oocyte Donation; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013480:Superovulation / Q000187:drug effects*; D057968:Transdermal Patch; D016896:Treatment Outcome; D014427:Twins
chemical_list: D005300:Fertility Agents, Female; D005640:Follicle Stimulating Hormone