title: Zinc-chelated imidazole groups for DNA polyion complex formation.
abstract: This communication presents the pH-dependent chelation of Zn(2+) ions with the imidazole groups of poly(1-vinylimidazole) (PVIm) and DNA polyion complex formation with the zinc-chelated PVIm (PVIm-Zn) via chelated Zn(2+) ions. The resulting PVIm-Zn/DNA complexes exhibit no significant cytotoxicity and show outstanding gene expression.
authors.affiliation: Department of Applied Chemistry, Tokyo Metropolitan University, Japan. asayama-shoichiro@tmu.ac.jp
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Asayama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishinohara
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kawakami
mesh_terms: D002614:Chelating Agents / Q000737:chemistry / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004587:Electrophoresis, Agar Gel; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry / Q000378:metabolism*; D007477:Ions; D011145:Polyvinyls / Q000737:chemistry / Q000378:metabolism*; D015032:Zinc / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002614:Chelating Agents; D007093:Imidazoles; D007477:Ions; D011145:Polyvinyls; C524090:poly(1-vinylimidazole); D004247:DNA; D015032:Zinc