title: Transient pseudohypoaldosteronism masquerading as congenital adrenal hyperplasia.
abstract: We report a six-week-old boy with genitourinary structural abnormalities who presented with profound hyponatraemia and hyperkalaemia due to transient type 1 pseudohypoaldosteronism (PHA) precipitated by a urinary tract infection (UTI), which responded rapidly to intravenous saline and antibiotics. In infants with structural abnormalities of the urinary tract, we wish to highlight the importance of recognizing type 1 PHA and its association with a UTI since prompt and appropriate treatment rapidly corrects the associated metabolic abnormalities. Conversely, the identification of type 1 PHA in an infant should precipitate a search for a UTI and structural abnormalities of the urinary tract.
authors.affiliation: Wolverhampton University, Wolverhampton, West Midlands, UK. logan.manikam@doctors.org.uk
authors.forename: L
authors.initials: L
authors.lastname: Manikam
authors.forename: M P
authors.initials: MP
authors.lastname: Cornes
authors.forename: D
authors.initials: D
authors.lastname: Kalra
authors.forename: C
authors.initials: C
authors.lastname: Ford
authors.forename: R
authors.initials: R
authors.lastname: Gama
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis*; D000450:Aldosterone / Q000097:blood; D046528:Chimerism; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D006801:Humans; D006947:Hyperkalemia / Q000175:diagnosis*; D007010:Hyponatremia / Q000175:diagnosis*; D007223:Infant; D008297:Male; D011546:Pseudohypoaldosteronism / Q000175:diagnosis*; D014551:Urinary Tract / Q000002:abnormalities*; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000450:Aldosterone