title: Combination therapy in pulmonary arterial hypertension: do we have the right strategy?
abstract: The management of pulmonary hypertension has already incorporated the use of multiple therapies into routine practice. Available therapies act principally through vasodilatation of the pulmonary arterial circulation through well-delineated mechanisms, although right ventricular function determines function and prognosis. Therefore, the goal of these therapies is effectively to preserve right ventricular function through reducing right ventricular afterload. The clinical trial experience of combination therapy is limited and the optimal combinations and administration strategies have yet to be clarified.
authors.affiliation: National Pulmonary Hypertension Service - London, Department of Cardiac Sciences, Hammersmith Hospital, Imperial College Healthcare NHS Trust, Du Cane Road, London, W12 0HS, UK.
authors.forename: Bhashkar
authors.initials: B
authors.lastname: Mukherjee
authors.forename: Luke
authors.initials: L
authors.lastname: Howard
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004359:Drug Therapy, Combination; D019317:Evidence-Based Medicine; D065627:Familial Primary Pulmonary Hypertension; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000503:physiopathology; D016896:Treatment Outcome; D014664:Vasodilation / Q000187:drug effects; D016278:Ventricular Function, Right / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents