title: The German SUCCESS C Study - The First European Lifestyle Study on Breast Cancer.
abstract: SUMMARY: Cohort trials have shown evidence that obesity and a low level of physical activity are not only associated with a higher risk of developing breast cancer, but also with an increased risk for recurrence and reduced survival in breast cancer patients. The SUCCESS C study is the first European trial to evaluate the effect of an intensive lifestyle intervention program on disease-free survival in women with early breast cancer and to examine the predictive value of selected biomarker candidates. A total of 3,547 women with early-stage, Her2/neu-negative breast cancer will be included. The first randomization will compare disease-free survival in patients treated with either 3 cycles of FEC (epirubicine, fluorouracil, cyclophosphamide), followed by 3 cycles of docetaxel or 6 cycles of docetaxel-cyclophosphamide, and thus assess the role of anthracycline-free chemotherapy. The second randomization compares disease-free survival in patients with a body mass index of 24-40 kg/m(2) receiving either a telephone-based individualized lifestyle intervention program aiming at moderate weight loss or general recommendations for a healthy lifestyle alone. In addition, the study will evaluate the predictive role of cancer-associated and obesity-related biomarkers for the prediction of disease recurrence and survival. This SUCCESS C trial will provide valuable information on the effects of a lifestyle intervention program on the prognosis of early breast cancer patients.
authors.affiliation: Ludwig-Maximilians-University München, Frauenklinik, Campus Innenstadt, München, Germany.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Rack
authors.forename: Ulrich
authors.initials: U
authors.lastname: Andergassen
authors.forename: Julia
authors.initials: J
authors.lastname: Neugebauer
authors.forename: Jessica
authors.initials: J
authors.lastname: Salmen
authors.forename: Philip
authors.initials: P
authors.lastname: Hepp
authors.forename: Harald
authors.initials: H
authors.lastname: Sommer
authors.forename: Werner
authors.initials: W
authors.lastname: Lichtenegger
authors.forename: Klaus
authors.initials: K
authors.lastname: Friese
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Beckmann
authors.forename: Dagmar
authors.initials: D
authors.lastname: Hauner
authors.forename: Hans
authors.initials: H
authors.lastname: Hauner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Janni