title: Alzheimer's pathogenesis: is there neuron-to-neuron propagation?
abstract: There is increasing interest in the early phase of Alzheimer's disease before severe neuronal dysfunction occurs, but it is still not known when or where in the central nervous system the underlying pathological process begins. In this review, we discuss the idea of possible disease progression from the locus coeruleus to the transentorhinal region of the cerebral cortex via neuron-to-neuron transmission and transsynaptic transport of tau protein aggregates, and we speculate that such a mechanism together with the very long prodromal period that characterizes Alzheimer's disease may be indicative of a prion-like pathogenesis for this tauopathy. The fact that AT8-immunoreactive abnormal tau aggregates (pretangles) develop within proximal axons of noradrenergic coeruleus projection neurons in the absence of both tau lesions (pretangles, NFTs/NTs) in the transentorhinal region as well as cortical amyloid-β pathology means that currently used neuropathological stages for Alzheimer's disease will have to be reclassified.
authors.affiliation: Clinical Neuroanatomy (Department of Neurology), Center for Clinical Research, University of Ulm, Ulm, Germany. heiko.braak@uni-ulm.de
authors.forename: Heiko
authors.initials: H
authors.lastname: Braak
authors.forename: Kelly
authors.initials: K
authors.lastname: Del Tredici
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D009474:Neurons / Q000473:pathology*; D017096:Prion Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology; D016875:tau Proteins / Q000009:adverse effects* / Q000502:physiology
chemical_list: D016875:tau Proteins