title: Direct functionalisation of group 10 N-heterocyclic carbene complexes for diversity enhancement.
abstract: The synthesis of alkyne-substituted N-heterocyclic carbene complexes of Pd(II) and Pt(II) is reported. Catalyzed 1,3-dipolar cycloaddition with azides has been applied as a modular way of functionalisation of group 10 transition metal NHC complexes to generate potentially new metallodrugs.
authors.affiliation: Institute of Physics and Chemistry of Materials of Strasbourg (IPCMS), University of Strasbourg - CNRS UMR7504, 23 rue du Loess, 67034 Strasbourg, France.
authors.forename: Edith
authors.initials: E
authors.lastname: Chardon
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Puleo
authors.forename: Georges
authors.initials: G
authors.lastname: Dahm
authors.forename: Gilles
authors.initials: G
authors.lastname: Guichard
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bellemin-Laponnaz
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D010984:Platinum / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D056831:Coordination Complexes; D006571:Heterocyclic Compounds; C030011:carbene; D010984:Platinum; D010165:Palladium; D008697:Methane