title: Vitamin D Deficiency in HIV-Infected Women on Antiretroviral Therapy Living in the Tropics.
abstract: The effects of HIV/AIDS and antiretroviral drugs on vitamin D metabolism are still mostly unknown. This was a cross-sectional study to estimate the prevalence of vitamin D deficiency and identify its association with the clinical and metabolic parameters among 214 HIV-positive female patients on antiretroviral therapy (ART) in Brazil. The prevalence of vitamin D deficiency (< 30 ng/ml) was 40.65% (87/214). Hypercholesterolemia, high LDL-c, duration of use of current antiretroviral regimen, hypertriglyceridemia, body mass index, age, hypertension, time with AIDS ≥ 10 years and hyperglycemia were selected for multivariate analysis (p < 0.20). After this analysis, hypercholesterolemia and use of current antiretroviral regimen ≥ 3 years remained independently associated with vitamin D deficiency. There was an inverse statistically significant correlation between total cholesterol and serum 25(OH)D levels. High prevalence of vitamin D deficiency was found among HIV-positive women on ART and was independently associated with its prolonged use and with hypercholesterolemia.
authors.affiliation: 1Department of Mother and Child Health, University of Pernambuco, School of Medical Sciences, Recife, Pernambuco, Brazil.
authors.forename: Tereza
authors.initials: T
authors.lastname: Conrado
authors.forename: Demócrito de Barros
authors.initials: Dde B
authors.lastname: Miranda-Filho
authors.forename: Ricardo Arraes de Alencar
authors.initials: RA
authors.lastname: Ximenes
authors.forename: Maria de Fátima
authors.initials: Mde F
authors.lastname: Albuquerque
authors.forename: Heloísa Ramos
authors.initials: HR
authors.lastname: Lacerda
authors.forename: Regina Coeli F
authors.initials: RC
authors.lastname: Ramos
authors.forename: Paulo Sérgio Ramos de
authors.initials: PS
authors.lastname: Araújo
authors.forename: Ulisses
authors.initials: U
authors.lastname: Montarroyos
authors.forename: Francisco
authors.initials: F
authors.lastname: Bandeira
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006679:HIV Seropositivity; D006801:Humans; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood
chemical_list: D014807:Vitamin D