title: Peptide synthesis 'in water' by a solution-phase method using water-dispersible nanoparticle Boc-amino acid.
abstract: Regulatory pressure has compelled the chemical manufacturing industry to reduce the use of organic solvents in synthetic chemistry, and there is currently a strong focus on replacing these solvents with water. Here, we describe an efficient in-water solution-phase peptide synthesis method using Boc-amino acids. It is based on a coupling reaction utilizing suspended water-dispersible nanoparticle reactants. Using this method, peptides were obtained in good yield and with high purity.
authors.affiliation: Faculty of Pharmaceutical Sciences & Cooperative Research Center of Life Sciences, Kobe Gakuin University, Chou-ku, Kobe 650-8586, Japan. hojo@pharm.kobegakuin.ac.jp
authors.forename: Keiko
authors.initials: K
authors.lastname: Hojo
authors.forename: Hideki
authors.initials: H
authors.lastname: Ichikawa
authors.forename: Mare
authors.initials: M
authors.lastname: Onishi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Fukumori
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawasaki
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D005563:Formic Acid Esters / Q000737:chemistry*; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D005563:Formic Acid Esters; D010455:Peptides; D012996:Solutions; D012997:Solvents; C000345:t-butyloxycarbonyl group; D014867:Water; D004743:Enkephalin, Leucine; C048614:enkephalinamide-Leu