title: Prognostic impact of CXCR4 and CXCR7 expression in pancreatic adenocarcinoma.
abstract: BACKGROUND
  Chemokines and their receptors are known to play important roles in the tumorigenesis of many malignancies. The aim of this study was to evaluate the prognostic impact of the expression of the chemokine receptors CXCR4 and CXCR7 in patients with pancreatic adenocarcinoma (PAC).
  
  
  METHODS
  Expression of CXCR4 and CXCR7 in specimens from 249 patients with PAC was evaluated by immunohistochemistry on a tissue microarray and matched with clinicopathological parameters and overall survival.
  
  
  RESULTS
  Expression of CXCR4 was detected in 215 patients (86.4%) and CXCR7 in 47 patients (18.9%). No association between CXCR4 and CXCR7 expression was evident, although all the CXCR7 positive tumors were also CXCR4 positive. pT1/2 tumors showed a higher frequency of CXCR7 expression than pT3/4 tumors (P = 0.018), while more dedifferentiated tumors had elevated CXCR7 expression (P = 0.036). Overall and disease-free survival revealed no association with either CXCR4 or CXCR7 expression.
  
  
  CONCLUSIONS
  CXCR7 is associated with tumor grade and inversely associated with tumor size and may play a potential role in tumor progression and differentiation. In contrast to previously reported data our results revealed no significant association between CXCR4 expression and clinical or pathological data.
authors.affiliation: Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. fgebauer@uke.uni-hamburg.de
authors.forename: Florian
authors.initials: F
authors.lastname: Gebauer
authors.forename: Michael
authors.initials: M
authors.lastname: Tachezy
authors.forename: Katharina
authors.initials: K
authors.lastname: Effenberger
authors.forename: Katharina
authors.initials: K
authors.lastname: von Loga
authors.forename: Hilke
authors.initials: H
authors.lastname: Zander
authors.forename: Alexander
authors.initials: A
authors.lastname: Marx
authors.forename: Jussuf T
authors.initials: JT
authors.lastname: Kaifi
authors.forename: Guido
authors.initials: G
authors.lastname: Sauter
authors.forename: Jakob R
authors.initials: JR
authors.lastname: Izbicki
authors.forename: Maximilian
authors.initials: M
authors.lastname: Bockhorn
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D054387:Receptors, CXCR / Q000096:biosynthesis*; D019718:Receptors, CXCR4 / Q000096:biosynthesis*; D046888:Tissue Array Analysis
chemical_list: C501896:ACKR3 protein, human; C527276:CXCR4 protein, human; D054387:Receptors, CXCR; D019718:Receptors, CXCR4