title: Hepatic consequences of vascular adhesion protein-1 expression.
abstract: The liver is constantly exposed to antigens present in the blood and to particulate antigens delivered from the gut. To maintain effective levels of immune surveillance and yet tolerate food antigens, the hepatic environment has become highly specialised. A low flow environment exists within the hepatic sinusoids that not only facilitates the exchange of toxins and nutrients within the liver parenchyma, but also provides an ideal niche for the recruitment of leukocytes. One such adhesion molecule involved in this process, the vascular adhesion protein-1 (VAP-1), is unusual in the context of the leukocyte adhesion cascade in that it is both an adhesion molecule and a primary amine oxidase. In this review, we examine the biological functions of VAP-1 and examine what role this molecule might play in the establishment and progression of chronic liver disease.
authors.affiliation: Centre for Liver Research and NIHR Biomedical Research Unit, 5th Floor, Institute of Biomedical Research, MRC Centre for Immune Regulation, College of Medicine and Dentistry, University of Birmingham, Birmingham, Edgbaston, B15 2TT, UK. c.j.weston@bham.ac.uk
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Weston
authors.forename: David H
authors.initials: DH
authors.lastname: Adams
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000502:physiology*; D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D002908:Chronic Disease; D003432:Cross-Linking Reagents / Q000494:pharmacology; D018450:Disease Progression; D022781:Hepatocytes / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008099:Liver / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000201:enzymology* / Q000473:pathology; D051379:Mice
chemical_list: D015815:Cell Adhesion Molecules; D003432:Cross-Linking Reagents; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing); C492678:semicarbazide-sensitive amine oxidase-vascular adhesion protein-1, mouse