title: Macular hole formation in fellow eyes with a perifoveal posterior vitreous detachment of patients with a unilateral macular hole.
abstract: OBJECTIVE
  To estimate the rate of macular hole formation in fellow eyes with a perifoveal posterior vitreous detachment (PVD) and early stage 1 intrafoveal lesions in patients with a unilateral idiopathic full-thickness macular hole (MH) using optical coherence tomography (OCT).
  
  
  METHODS
  Retrospective observational case series.
  
  
  METHODS
  Fellow eyes of consecutive patients with a unilateral full-thickness MH were examined on OCT. A subset of fellow eyes with a perifoveal PVD had been followed to investigate the rates of macular hole formation in fellow eyes with early stage 1 intrafoveal lesions.
  
  
  RESULTS
  Of 176 patients with a unilateral full-thickness MH, 42 fellow eyes (42 patients) with a perifoveal PVD were identified. During follow-up, a foveolar detachment was seen in 16 eyes, and 4 eyes had a foveal pseudocyst alone. In the 16 eyes with a foveolar detachment, 9 eyes had concurrent inner foveal splits. Within another 2 years of follow-up, OCT showed that 5 of 16 fellow eyes (31%) with a foveolar detachment developed a second full-thickness MH and 5 of 9 fellow eyes with a foveolar detachment and inner foveal splits developed a second full-thickness MH. Two of 4 eyes with a foveal pseudocyst alone developed vitreofoveal separation without hole formation. The remaining 2 eyes with a foveal pseudocyst alone remained stable at the last follow-up visit.
  
  
  CONCLUSIONS
  Fellow eyes with a foveolar detachment and a perifoveal PVD may be at high risk, and fellow eyes with a foveolar detachment and inner foveal splits might be at higher risk for progression to macular hole formation.
authors.affiliation: Department of Ophthalmology, Asahikawa Medical University, Asahikawa, 2-1-1-1 Midorigaoka-Higashi, Hokkaido, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Yoshida
authors.forename: Taiji
authors.initials: T
authors.lastname: Nagaoka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kagokawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kato
authors.forename: Akira
authors.initials: A
authors.lastname: Takamiya
authors.forename: Eiichi
authors.initials: E
authors.lastname: Sato
authors.forename: Harumasa
authors.initials: H
authors.lastname: Yokota
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishiko
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hirokawa
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology*; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012167:Retinal Perforations / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D041623:Tomography, Optical Coherence; D020255:Vitreous Detachment / Q000150:complications* / Q000175:diagnosis