title: Predictors of CD4 eligibility for antiretroviral therapy initiation among HIV-infected pregnant women in Lusaka, Zambia.
abstract: BACKGROUND
  In resource-limited settings, CD4 testing is a barrier to antiretroviral therapy initiation in pregnancy.
  
  
  METHODS
  We used logistic regression to identify predictors of CD4 cell count ≤ 350 cells/uL in 20,233 pregnant women.
  
  
  RESULTS
  The best-performing model included any 3 of: age ≥ 28 years old, hemoglobin ≤ 9.8 g/dL, gestational age ≤ 30 weeks, weight ≤ 64 kg, history of tuberculosis or previous death of an infant prior to one year old. Sensitivity was 45.7% (95% CI: 44.5-47.0), specificity 70.7% (95% CI: 69.6-71.8), and misclassification rate 41.4% (95% CI: 40.5-42.2).
  
  
  CONCLUSIONS
  CD4 triage remains a critical element of maternal HIV care and PMTCT.
authors.affiliation: Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. cherry.liu@cidrz.org
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Liu
authors.forename: Jessica
authors.initials: J
authors.lastname: Mulindwa
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Giganti
authors.forename: Nande B
authors.initials: NB
authors.lastname: Putta
authors.forename: Namwinga
authors.initials: N
authors.lastname: Chintu
authors.forename: Benjamin H
authors.initials: BH
authors.lastname: Chi
authors.forename: Jeffrey S A
authors.initials: JS
authors.lastname: Stringer
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Stringer
mesh_terms: D000328:Adult; D000367:Age Factors; D019380:Anti-HIV Agents / Q000191:economics / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D004522:Educational Status; D005260:Female; D005865:Gestational Age; D015658:HIV Infections / Q000188:drug therapy* / Q000191:economics / Q000635:transmission*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D016015:Logistic Models; D008954:Models, Biological; D011237:Predictive Value of Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000191:economics; D011295:Prenatal Care; D012189:Retrospective Studies; D012307:Risk Factors; D015024:Zambia
chemical_list: D019380:Anti-HIV Agents; D006454:Hemoglobins