title: Encapsulation of phthalocyanine supramolecular stacks into virus-like particles.
abstract: We report herein the encapsulation of a water-soluble phthalocyanine (Pc) into virus-like particles (VLPs) of two different sizes, depending on the conditions. At neutral pH, the cooperative encapsulation/templated assembly of the particles induces the formation of Pc stacks instead of Pc dimers, due to an increased confinement concentration. The Pc-containing VLPs may potentially be used as photosensitizer/vehicle systems for biomedical applications such as photodynamic therapy.
authors.affiliation: Laboratory for Biomolecular Nanotechnology, MESA+ Institute, University of Twente, P.O. Box 207, 7500 AE Enschede, The Netherlands.
authors.forename: Melanie
authors.initials: M
authors.lastname: Brasch
authors.forename: Andrés
authors.initials: A
authors.lastname: de la Escosura
authors.forename: Yujie
authors.initials: Y
authors.lastname: Ma
authors.forename: Charlotte
authors.initials: C
authors.lastname: Uetrecht
authors.forename: Albert J R
authors.initials: AJ
authors.lastname: Heck
authors.forename: Tomás
authors.initials: T
authors.lastname: Torres
authors.forename: Jeroen J L M
authors.initials: JJ
authors.lastname: Cornelissen
mesh_terms: D000818:Animals; D002214:Capsules; D002460:Cell Line; D007211:Indoles / Q000008:administration & dosage / Q000737:chemistry*; D054833:Isoindoles; D051379:Mice; D010316:Particle Size; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000737:chemistry*; D014771:Virion / Q000737:chemistry*
chemical_list: D002214:Capsules; D007211:Indoles; D054833:Isoindoles; D014677:Pharmaceutical Vehicles; D011838:Radiation-Sensitizing Agents; C013647:phthalocyanine