title: Intracranial aneurysm coiling with PGLA-coated coils versus bare platinum coils: long-term anatomic follow-up.
abstract: BACKGROUND
  The purpose of this study is to compare the long-term (≥12 months) angiographic follow-up of aneurysms treated with polymer polyglycolic-lactic acid (PGLA)-coated coils versus bare platinum coils.
  
  
  METHODS
  Long-term angiographic follow-up results of 90 aneurysms treated exclusively with PGLA-coated coils were retrospectively analyzed and compared to those of 158 aneurysms treated exclusively with bare platinum coils.
  
  
  RESULTS
  There were 32 ruptured aneurysms (35.5%) in the PGLA-coated coil group and 62 (39.2%) in the bare platinum coil group. The mean angiographic follow-up was 29 months in the PGLA-coated coil group versus 27 months in the bare platinum coil group (P = 0.2297). The mean time to angiographic recurrence was 14 months in the PGLA-coated coil group versus 18 months in the bare platinum coil group (P = 0.1088). Recurrence rates were 35.6% (32/90) and 31.0% (49/158) in the PGLA-coated coil and bare platinum coil groups, respectively (P = 0.4837). The major recurrence justifying retreatment was 5.6% (5/90) in the PGLA-coated coil group versus 6.7% (10/158) in the bare platinum coil group (P = 1.000).
  
  
  CONCLUSIONS
  PGLA-coated coils provided no better long-term recanalization rates than bare platinum coils.
authors.affiliation: Department of Interventional Neuroradiology, Foundation Rothschild Hospital, Paris, France. mpiotin@free.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Piotin
authors.forename: Silvia
authors.initials: S
authors.lastname: Pistocchi
authors.forename: Bruno
authors.initials: B
authors.lastname: Bartolini
authors.forename: Raphaël
authors.initials: R
authors.lastname: Blanc
mesh_terms: D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging* / Q000628:therapy*; D002533:Cerebral Angiography; D020099:Coated Materials, Biocompatible; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000628:therapy*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010984:Platinum; D011100:Polyglycolic Acid; D015641:Radiography, Interventional; D012008:Recurrence; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D011100:Polyglycolic Acid; D010984:Platinum