title: Opposing roles for dopamine D1- and D2-like receptors in discrete cue-induced reinstatement of food seeking.
abstract: We used a rat reinstatement model to test the involvement of dopamine D1- and D2-like receptors in discrete cue-induced reinstatement of food seeking. At a dose that did not alter responding during food self-administration, the D1-like antagonist SCH-23390 blocked reinstatement of food seeking, while the D2-like antagonist eticlopride significantly increased reinstatement responding. Thus, these results establish opposing roles for D1- and D2-like receptors in discrete cue-induced relapse to food seeking.
authors.affiliation: Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., Bloomsburg, PA, USA. kball@bloomu.edu
authors.forename: Kevin T
authors.initials: KT
authors.lastname: Ball
authors.forename: Tarra A
authors.initials: TA
authors.lastname: Combs
authors.forename: Denise N
authors.initials: DN
authors.lastname: Beyer
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D003463:Cues; D018492:Dopamine Antagonists / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D005108:Extinction, Psychological; D005502:Food; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D012055:Reinforcement Schedule; D012457:Salicylamides / Q000494:pharmacology
chemical_list: D001552:Benzazepines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; C534628:SCH 23390; D012457:Salicylamides; C045989:eticlopride