title: Maternal asthma, race and low birth weight deliveries.
abstract: BACKGROUND
  Asthma during pregnancy may compromise the well-being of the fetus and potentially impact an infant's birth weight via different mechanisms.
  
  
  OBJECTIVE
  1) To assess the influence of asthma during pregnancy on the incidence of LBW outcomes in white non-Hispanic (WNH) and black non-Hispanic (BNH) women. 2) To identify other risk factors that affect low birth weight (LBW) (birth weight<2500g) outcomes among asthmatic women.
  
  
  METHODS
  We conducted a retrospective analysis of compiled perinatal data on 17,073 patients including 9348 WNH and 7725 BNH women delivering at the George Washington University Hospital between 1990 and 2003. Univariate and logistic regression analyses were used to examine associations.
  
  
  RESULTS
  A total of 423 (2.5%) women had an asthma diagnosis, with a higher incidence in BNH women when compared to WNH women (3.4% vs. 1.7%, P<0.001). In the WNH population, asthmatic women had higher incidences of gravidity, thyroid disease, and illicit drug use, whereas in the BNH population, asthmatic women had higher incidences of increased body mass index (BMI), and use of alcohol, tobacco and illicit drugs. After controlling for confounders in multiple logistic regression analyses, there was an association between asthma and LBW outcomes in BNH women (OR: 1.7, CI: 1.1-2.6, p=0.01), but not in WNH women (OR=0.99, CI=0.5-2.2, p=0.97).
  
  
  CONCLUSIONS
  Asthma during pregnancy is a risk factor for LBW outcomes in BNH but not WNH women. The increased alcohol and illicit drug use in BNH women with asthma is an unexpected finding that deserves further study.
authors.affiliation: Department of Neonatology, the George Washington University and Children's National Medical Center, Washington, DC, USA. haly@mfa.gwu.edu
authors.forename: Hany
authors.initials: H
authors.lastname: Aly
authors.forename: Ayman
authors.initials: A
authors.lastname: Nada
authors.forename: Tahmina
authors.initials: T
authors.lastname: Ahmad
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mohamed
authors.forename: An N
authors.initials: AN
authors.lastname: Massaro
authors.forename: Susanne
authors.initials: S
authors.lastname: Bathgate
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Macri
authors.forename: John W
authors.initials: JW
authors.lastname: Larsen
mesh_terms: D001741:Black or African American; D001249:Asthma / Q000453:epidemiology / Q000208:ethnology / Q000503:physiopathology*; D015331:Cohort Studies; D004219:District of Columbia / Q000453:epidemiology; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology*; D007231:Infant, Newborn; D016015:Logistic Models; D015999:Multivariate Analysis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000208:ethnology / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D044465:White People