title: [Study on the meningoima using FT-mid-IR spectroscopy].
abstract: In the present investigation, 24 cases of meningoima tissues (including 12 cases of benign tumor and 12 cases of malignant tumor 12) were detected using FT-mid-IR spectroscopy linked with attenuated total reflectance (ATR) accessory. These FTIR spectra obtained from the above-mentioned meningoima tissues were analyzed and compared. Significant differences were found in the spectral features of different kinds of meningoima tissues for example fibrous type meningoima and endothelioid meningoima; and for the same type of meningoima tissues the significant differences in the spectram features can be also observed with the increase of grade malignancy. The malignant tumor can be distinguished primarily from benign tumor by the changes of position, shape and intensity of infrared absorption bands, particularly in the ranges of 1 000-1 500 cm(-1). The results show that the peak position of the bands (such as 1 160 cm(-1)) can be used to distinguish the characteristic of meningoima which are in agreement with the pathological results. The accuracy is larger than 85%. These results demonstrate that FT-mid-IR spectroscopy exhibits prospect to develop a novel, non-invasive and rapid method for the diagnosis the brain tumors.
authors.affiliation: College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. weiqingw@sina.com
authors.forename: Wei-Qing
authors.initials: WQ
authors.lastname: Wan
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Pan
authors.forename: Gui-Jun
authors.initials: GJ
authors.lastname: Jia
authors.forename: Yi-Zhuang
authors.initials: YZ
authors.lastname: Xu
authors.forename: Guo-Qiao
authors.initials: GQ
authors.lastname: Lai
authors.forename: Shao-Xuan
authors.initials: SX
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Yang
authors.forename: Yuan-Fu
authors.initials: YF
authors.lastname: Zhang
authors.forename: Shi-Fu
authors.initials: SF
authors.lastname: Weng
authors.forename: Jin-Guang
authors.initials: JG
authors.lastname: Wu
mesh_terms: D006801:Humans; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*