title: Synthesis and antibacterial activity of alaremycin derivatives for the porphobilinogen synthase.
abstract: The preparation and the antibacterial activity of alaremycin derivatives such as their CF(3)-derivatives and (R)- and (S)-4-oxo-5-acetylaminohexanoic acid for the porphobilinogen synthase (PBGS), were described. The IC(50) values of the antibacterial activity of the prepared materials for the inhibitor of PBGS, were determined using PBGS assay.
authors.affiliation: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226-8501, Japan.
authors.forename: Noritaka
authors.initials: N
authors.lastname: Iwai
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Nakayama
authors.forename: Jumpei
authors.initials: J
authors.lastname: Oku
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kitazume
mesh_terms: D000614:Aminocaproates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001681:Biological Assay; D005617:Chlorofluorocarbons, Methane / Q000737:chemistry; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D000623:Porphobilinogen Synthase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011549:Pseudomonas / Q000187:drug effects*
chemical_list: D000614:Aminocaproates; D000900:Anti-Bacterial Agents; D005617:Chlorofluorocarbons, Methane; C506902:alaremycin; D000623:Porphobilinogen Synthase; C009554:fluoroform