title: Drug release kinetics and physicochemical characteristics of floating drug delivery systems.
abstract: BACKGROUND
  Absorption of drugs through the gastrointestinal tract poses a variety of limitations, making the in vivo performance of drug delivery systems uncertain. Following on from recent advances, in a time of increased consideration of floating drug delivery systems, it is as important as ever to continue the progress by studying different aspects of these systems. Moreover, it seems imperative to gain a deeper insight into drug release mechanisms, in order to design a more systematic and intellectual floating system.
  
  
  METHODS
  This paper summarizes current approaches in the research and development of ideal floating drug delivery systems, from recent literature. Also, in order to have predictability and reproducibility in designing an efficient floating dosage form, some kinetic studies are mentioned, and the drug release mechanism from floating drug delivery systems is discussed.
  
  
  CONCLUSIONS
  Developing an efficient floating dosage form is reliant on a better understanding of the relation between formulation variables and performance of the floating systems. Generally, the combination of two buoyancy mechanisms and gas-generating systems with swellable polymers would be beneficial for obtaining an appropriate floating lag time and duration of buoyancy, which in turn guarantees optimum efficiency of the pharmaceutical dosage form.
authors.affiliation: Tabriz University of Medical Sciences, Biotechnology Research Center and Faculty of Pharmacy, Tabriz 51664, Iran.
authors.forename: Khosro
authors.initials: K
authors.lastname: Adibkia
authors.forename: Sanaz
authors.initials: S
authors.lastname: Hamedeyazdan
authors.forename: Yousef
authors.initials: Y
authors.lastname: Javadzadeh
mesh_terms: D000818:Animals; D004304:Dosage Forms; D016503:Drug Delivery Systems; D006801:Humans; D010599:Pharmacokinetics; D015203:Reproducibility of Results
chemical_list: D004304:Dosage Forms