title: [Intraocular levels of pigment epithelium-derived factor in patients with active uveitis].
abstract: OBJECTIVE
  Pigment epithelium-derived factor (PEDF) is an antiangiogenic/neurotrophic dual functional factor, and recently it was also shown to mediate antioxidative and anti-inflammatory action. The purpose of this study was to evaluate the levels of PEDF in the aqueous humor in eyes with idiopathic acute anterior uveitis (IAAU).
  
  
  METHODS
  A comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with IAAU. The control group included 20 aqueous humor samples from 20 patients who underwent a cataract surgery and without any other ocular or systemic diseases. Levels of PEDF were determined with the ELISA test.
  
  
  RESULTS
  Concentration of PEDF in aqueous humor was remarkably higher in patients with IAAU than in control subjects (Mann-Whitney U test, P<.001). Levels of PEDF were 6,291,637.70±8,564,836.48 pg/ml (mean±SD) in eyes with IAAU and 449,178.10±158,670.19 pg/ml in the eyes of the control group.
  
  
  CONCLUSIONS
  The aqueous humor PEDF levels are increased in eyes with IAAU and may be increased as self-protection against inflammation.
authors.affiliation: Departamento de Oftalmología, Hospital Universitario La Fe, Valencia, España. crismarinlambies@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: Marín-Lambíes
authors.forename: D
authors.initials: D
authors.lastname: Salom
authors.forename: S
authors.initials: S
authors.lastname: García-Delpech
authors.forename: M
authors.initials: M
authors.lastname: Díaz-Llopis
mesh_terms: D000208:Acute Disease; D000328:Adult; D001082:Aqueous Humor / Q000737:chemistry*; D002387:Cataract Extraction; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000032:analysis*; D015843:Serpins / Q000032:analysis*; D014606:Uveitis, Anterior / Q000378:metabolism*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor