title: Outcome of renal transplantation in children: a multi-center national report from Iran.
abstract: The outcome of pediatric renal transplantation was previously reported by a single-center study at the year 2006. Therefore, we aimed to evaluate and report the characteristics and outcome of renal pediatric renal transplantation in a multi-center nationwide study. In this nationwide report, medical records of 907 children (≤18yr) with renal transplantation in eight major pediatric transplant centers of Iran were recorded. These 907 patients received a total of 922 transplants. All children who failed to follow-up were excluded. Rather than baseline characteristics, graft and patient outcomes were considered for survival analysis. For further analysis, they were divided into two groups: patients who had graft survival time more than 10yr (n=91) and the ones with graft survival time of equal or less than 10yr (n=831). Of 922 recipients, 515 (55.8%) were boys and 407 (44.2%) were girls with the mean age of 13.10 (s.d.=3.54) yr. DGF and AR were occurred in 10% and 39.5% of the transplanted children, respectively. Transplantation year, dialyzing status before transplantation, DGF, and AR were significant enough to predict graft survival in cox regression model (overall model: p<0.001). Nowadays, there is a successful live donor pediatric renal transplantation in Iran. Graft survival has improved in our recipients and now the graft survival rates are near to international standards.
authors.affiliation: Urology and Nephrology Research Center, Shaheed Beheshti University of Medical Science, Labbafi Nejad Hospital, Ali Asghar Children's Hospital, Tehran, Iran. hasanotukesh@yahoo.com
authors.forename: Hasan
authors.initials: H
authors.lastname: Otukesh
authors.forename: Rozita
authors.initials: R
authors.lastname: Hoseini
authors.forename: Nahid
authors.initials: N
authors.lastname: Rahimzadeh
authors.forename: Seyed-Mohammad
authors.initials: SM
authors.lastname: Fereshtehnejad
authors.forename: Naser
authors.initials: N
authors.lastname: Simfroosh
authors.forename: Abbas
authors.initials: A
authors.lastname: Basiri
authors.forename: Mostafa
authors.initials: M
authors.lastname: Sharifian
authors.forename: Ghamar Hoseini
authors.initials: GH
authors.lastname: Hashemi
authors.forename: Hosein
authors.initials: H
authors.lastname: Falahzadeh
authors.forename: Ali
authors.initials: A
authors.lastname: Derakhshan
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Fazel
authors.forename: Darioush
authors.initials: D
authors.lastname: Reiesee
authors.forename: Abdolhasan
authors.initials: A
authors.lastname: Sayedzadeh
authors.forename: Shams
authors.initials: S
authors.lastname: Vazirian
authors.forename: Ahmad Ali
authors.initials: AA
authors.lastname: Nikibakhsh
authors.forename: Ali Ghafari
authors.initials: AG
authors.lastname: Moghadam
authors.forename: Hashem
authors.initials: H
authors.lastname: Mohamadzadeh
authors.forename: Ali
authors.initials: A
authors.lastname: Naderi
authors.forename: Taher
authors.initials: T
authors.lastname: Isfahani
authors.forename: Faezeh
authors.initials: F
authors.lastname: Larijani
authors.forename: Hadi
authors.initials: H
authors.lastname: Shorkhi
authors.forename: Abazar Akbarzadeh
authors.initials: AA
authors.lastname: Pasha
authors.forename: Heshmatollah
authors.initials: H
authors.lastname: Shahbazian
authors.forename: Ehsan
authors.initials: E
authors.lastname: Valavi
authors.forename: Fakhrolsadat
authors.initials: F
authors.lastname: Mortazavi
authors.forename: Allaleh
authors.initials: A
authors.lastname: Gheisari
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000628:therapy; D005923:Glomerulosclerosis, Focal Segmental / Q000628:therapy; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007492:Iran; D007676:Kidney Failure, Chronic / Q000628:therapy*; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D016016:Proportional Hazards Models; D051437:Renal Insufficiency / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome