title: [Neuroprotective effects of lipoic acid and superoxide dismutase in the rat model of cerebral ischemia].
abstract: BACKGROUND
  the present study was aimed at investigation of neuroprotective effects of alpha-lipoic acid (LA) and superoxide dismutase (SOD) in brain ischemia in rats.
  
  
  METHODS
  two models were used to produce brain ischemia: focal ischemia (permanent left middle cerebral artery occlusion) and permanent ligation of both CCA without subsequent reperfusion. Cu/Zn-SOD at a dose 5 mg/kg, i.v. and LA at a dose of 20 mg/kg, i.p. were injected 30 minutes prior or 5 minutes after onset of ischemia. The end-points of the study were histochemically determined: infarction size, ultrastructural changes in the cerebral tissue, and survival rate.
  
  
  RESULTS
  LA administration 30 minutes prior to ischemia dramatically reduced infarction size (p < 0.001). Injection of LA 5 minutes after beginning of ischemia did not affect the infarction size. Besides, infarction ion size was unchanged after injection of SOD 30 minutes prior to ischemia.
  
  
  CONCLUSIONS
  the LA treatment regimen used in this study resulted in significant cerebral protection against ischemia. In contrast, SOD did not show any protective effects in focal and forebrain ischemia.
authors.forename: A A
authors.initials: AA
authors.lastname: Shmonin
authors.forename: E V
authors.initials: EV
authors.lastname: Mel'nikova
authors.forename: I V
authors.initials: IV
authors.lastname: Churilova
authors.forename: T D
authors.initials: TD
authors.lastname: Vlasov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D020520:Brain Infarction / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D008297:Male; D016548:Prosencephalon / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000494:pharmacology*; D008063:Thioctic Acid / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D008063:Thioctic Acid; D013482:Superoxide Dismutase