title: Efficacy and tolerability of methotrexate in severe childhood alopecia areata.
abstract: BACKGROUND
  Alopecia areata (AA) occurring in childhood is associated with a poorer prognosis than adult AA and may severely affect quality of life. The efficacy of methotrexate (MTX) was reported in adults with AA but there is little information about its use in children.
  
  
  OBJECTIVE
  We aimed to assess the efficacy and safety of MTX in severe childhood AA.
  
  
  METHODS
  We conducted a retrospective study including children with severe AA treated with MTX in the Departments of Paediatric Dermatology in France between November 2005 and December 2009.
  
  
  RESULTS
  Fourteen children (eight girls and six boys) aged between 8 and 18 years (mean 14·7) were included. AA was present for a mean duration of 5·7 years (range 2 months-11 years 8 months). The treatment was administered once weekly, the mean maximal dose was 18·9 mg weekly (range 15-25) and the mean duration of treatment was 14·2 months (range 1-31). Thirteen children were assessable. Of these 13 children, MTX was considered as successful (regrowth >50% of hair) for five of them. The remaining eight children were considered treatment failures. No serious side-effects were reported.
  
  
  CONCLUSIONS
  The efficacy of MTX in children with severe AA is variable. MTX may be considered for severe childhood AA in the absence of alternative effective treatments.
authors.affiliation: Department of Dermatology, Toulouse Hospital, Toulouse University, Toulouse, France. royer_marie@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Royer
authors.forename: C
authors.initials: C
authors.lastname: Bodemer
authors.forename: P
authors.initials: P
authors.lastname: Vabres
authors.forename: C
authors.initials: C
authors.lastname: Pajot
authors.forename: S
authors.initials: S
authors.lastname: Barbarot
authors.forename: C
authors.initials: C
authors.lastname: Paul
authors.forename: J
authors.initials: J
authors.lastname: Mazereeuw
mesh_terms: D000293:Adolescent; D000506:Alopecia Areata / Q000188:drug therapy*; D002648:Child; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D008727:Methotrexate