title: Amorphous calcium phosphate/poly(D,L-lactic acid) composite nanofibers: electrospinning preparation and biomineralization.
abstract: Amorphous calcium phosphate (ACP) has been recognized as an attractive biomaterial due to its bioactivity and biocompatibility. Electrospinning is a simple and low-cost way to fabricate polymer fibers. In this study, ACP nanoparticles with diameters ranging from 20 to 80 nm were synthesized using a simple precipitation method. ACP nanoparticles were hybridized with poly(D,L-lactic acid) (PDLLA) to form ACP/PDLLA composite nanofibers by electrospinning, and different architectures including the nanofibrous mesh and tube consisting of ACP/PDLLA composite nanofibers were obtained and characterized. The biomineralization and cytocompatibility of as-prepared ACP/PDLLA composite nanofibers were evaluated in vitro. Osteoblast-like MG63 cells were seeded on the ACP/PDLLA composite nanofiber meshes to perform the cytocompatibility evaluation. The ACP/PDLLA composite nanofibers exhibited a fast mineralization behavior in the simulated body fluid. The attachment of MG63 cells and cytotoxicity of ACP/PDLLA composite nanofibers were also evaluated, and the experiments indicated good biocompatibility and bioactivity of ACP/PDLLA composite nanofibers.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, PR China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ma
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Ting
authors.initials: T
authors.lastname: Cui
authors.forename: Xuan-Yong
authors.initials: XY
authors.lastname: Liu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002113:Calcification, Physiologic; D002130:Calcium Phosphates / Q000737:chemistry* / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival; D004867:Equipment Design; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry* / Q000378:metabolism; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism; D011091:Polyesters; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D011091:Polyesters; D011108:Polymers; C519480:amorphous calcium phosphate; D019344:Lactic Acid; C033616:poly(lactide)