title: Inhibitory effect of a serine protease inhibitor, FOY-305 on the invasion and metastasis of human pancreatic cancers.
abstract: We examined the inhibitory effect of a serine protease inhibitor, FOY-305, on the invasion and metastasis of human pancreatic cancers. The in vitro matrigel invasion assay showed that the invasiveness of Capan-1 human pancreatic cancer cells was inhibited by FOY-305 treatment in a dose-dependent manner at concentrations greater than 100 nM. Intrasplenic injection of Capan-1 cells in nude mice resulted in frequent metastases to liver, however, its incidence was significantly decreased by FOY-305 treatment. These findings suggest that a serine protease inhibitor, FOY-305 can inhibit tumor invasion and metastasis by blocking the serine protease-mediated activation cascade.
authors.affiliation: KANAZAWA UNIV,SCH MED,DEPT SURG,KANAZAWA,ISHIKAWA 920,JAPAN. KANAZAWA UNIV,SCH MED,DEPT ANAT,KANAZAWA,ISHIKAWA 920,JAPAN. KANAZAWA UNIV,SCH MED,DEPT PATHOL,KANAZAWA,ISHIKAWA 920,JAPAN. TOTTORI UNIV,FAC MED,DEPT PATHOL,YONAGO,TOTTORI 683,JAPAN.
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: F
authors.initials: F
authors.lastname: Futagami
authors.forename: H
authors.initials: H
authors.lastname: Tajima
authors.forename: H
authors.initials: H
authors.lastname: Kitagawa
authors.forename: M
authors.initials: M
authors.lastname: Kayahara
authors.forename: T
authors.initials: T
authors.lastname: Nagakawa
authors.forename: K
authors.initials: K
authors.lastname: Miwa
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Iseki
authors.forename: Y
authors.initials: Y
authors.lastname: Nakanuma
authors.forename: T
authors.initials: T
authors.lastname: Terada