title: Synthesis and development of a multifunctional self-decontaminating polyurethane coating.
abstract: A unique, durable, nonleaching antimicrobial urethane coating possessing energy-dampening properties is reported. Five novel diol-functionalized quaternary ammonium bromide salts were designed, synthesized, and cross-linked with a commercial polyisocyanate to afford novel multifunctional self-decontaminating coatings. Leaching of the antimicrobial into the environment is eliminated because of the biocidal tether. The effectiveness of these molecules to self-concentrate at the air-polymer interface without addition of other surface modifying additives proved extremely advantageous, and consequently resulted in microphase separation as confirmed by AFM. The coatings were designed to continuously decontaminate against a variety of pathogenic bacteria in addition to affording preliminary dampening properties. Minimum inhibitory concentration studies as well as surface antimicrobial evaluations were conducted using both Gram-positive and Gram-negative bacteria. Additionally, viscoelastic properties, hardness, tack, and surface energy measurements were used to correlate with coating performance.
authors.affiliation: Chemistry Division, Naval Research Laboratory, 4555 Overlook Avenue SW, Code 6100, Washington, DC 20375, USA. james.wynne@nrl.navy.mil
authors.forename: James H
authors.initials: JH
authors.lastname: Wynne
authors.forename: Preston A
authors.initials: PA
authors.lastname: Fulmer
authors.forename: D Michelle
authors.initials: DM
authors.lastname: McCluskey
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Mackey
authors.forename: J Paige
authors.initials: JP
authors.lastname: Buchanan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D018625:Microscopy, Atomic Force; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D011140:Polyurethanes; D000644:Quaternary Ammonium Compounds