title: Role of conventional therapies in the era of biological treatment in Crohn's disease.
abstract: Outstanding progress regarding the pathophysiology of Crohn's disease (CD) has led to the development of innovative therapeutic concepts. Numerous controlled trials have been performed in CD. This review concentrates on the results of randomized, placebo-controlled trials, and meta-analyses when available, that provide the highest degree of evidence. Current guidelines on the management of CD recommend a step-up approach to treatment involving the addition of more powerful therapies as the severity of disease and refractoriness to therapy increase. The advent of biological drugs has opened new therapeutic horizons for treating CD, modifying the treatment goals. However, the large majority of patients with CD will be managed through conventional therapy, even if they are a prelude to biological therapy.
authors.affiliation: Department of Clinical Medicine, University of Bologna, 40138 Bologna, Italy. paolo.gionchetti@unibo.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Gionchetti
authors.forename: Carlo
authors.initials: C
authors.lastname: Calabrese
authors.forename: Rosy
authors.initials: R
authors.lastname: Tambasco
authors.forename: Ramona
authors.initials: R
authors.lastname: Brugnera
authors.forename: Giulia
authors.initials: G
authors.lastname: Straforini
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Liguori
authors.forename: Giulia Spuri
authors.initials: GS
authors.lastname: Fornarini
authors.forename: Donatella
authors.initials: D
authors.lastname: Riso
authors.forename: Massimo
authors.initials: M
authors.lastname: Campieri
authors.forename: Fernando
authors.initials: F
authors.lastname: Rizzello
mesh_terms: D003424:Crohn Disease / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D015201:Meta-Analysis as Topic; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction
chemical_list: D010919:Placebos