title: In vitro and in vivo MRS study of human glioma metabolites.
abstract: In this study an in vitro multinuclear magnetic resonance spectroscopy (MRS) characterization of water soluble metabolites and of the lipid fraction obtained from 19 human gliomas (12 glioblastomas, 3 anaplastic astrocytomas, 2 anaplastic oligodendrogliomas and 2 oligodendrogliomas) with a total of 27 surgical specimens, is reported. Moreover, some in vivo H-1 MRS results are shown. The regional metabolic heterogeneity of glioblastomas, according to their morphological heterogeneity, is documented. For glioblastomas a specific in vitro H-1 MRS metabolite profile cannot be defined. Low and high grade oligodendrogliomas showed characteristic choline/creatine and alanine/creatine metabolite ratios. The spectroscopical characterization of histopathological factors concerning malignant gliomas is shown.
authors.affiliation: CNR,IST CITOMORFOL NORMALE & PATOL,I-40136 BOLOGNA,ITALY. CNR,ICOCEA,AREA RIC,I-40129 BOLOGNA,ITALY. UNIV BOLOGNA,OSPED BELLARIA,SERV NEURORADIOL,I-40139 BOLOGNA,ITALY. UNIV BOLOGNA,OSPED BELLARIA,DIV NEUROCHIRURG,I-40139 BOLOGNA,ITALY.
authors.forename: V
authors.initials: V
authors.lastname: Tugnoli
authors.forename: M
authors.initials: M
authors.lastname: Tosi
authors.forename: G
authors.initials: G
authors.lastname: Barbarella
authors.forename: R
authors.initials: R
authors.lastname: Ricci
authors.forename: F
authors.initials: F
authors.lastname: Calbucci
authors.forename: A
authors.initials: A
authors.lastname: Bertoluzza