title: [Effect of head-down tilt on respiratory responses and human inspiratory muscles activity].
abstract: The effect of head-down tilt on respiration and diaphragmal and parasternal muscles activity was investigated in 11 healthy subjects. The short-time (30 min) head-down tilt posture (-30 degrees relatively horizont) increased the inspiratory time (P < 0.05), decreased breathing frequency (P < 0.05), inspiratory and expiratory flow rate (P < 0.05) and increased the airway resistance (P < 0.05) compared with values in vertical posture. There were no significant changes in tidal volume and minute ventilation. Constant values of tidal volume and minute ventilation during head-down tilt were provided by increasing in EMG activity of parasternal muscles more then twice. It was established that the contribution of chest wall inspiratory muscles increased while the diaphragm's contribution decreased during head-down spontaneous breathing. Maximal inspiratory effort (Muller's maneuver) during head-down tilt evoked the opposite EMG-activity pattern: the contribution of inspiratory thoracic muscles was decreased and diaphragm's EMG-activity was increased compared with vertical posture. These results suggest that coordinate modulations in inspiratory muscles activity allows to preserve the functional possibility of human inspiratory muscles during short-time head-down tilt.
authors.forename: M O
authors.initials: MO
authors.lastname: Segizbaeva
authors.forename: M A
authors.initials: MA
authors.lastname: Pogodin
authors.forename: I N
authors.initials: IN
authors.lastname: Lavrova
authors.forename: M V
authors.initials: MV
authors.lastname: Balykin
authors.forename: N P
authors.initials: NP
authors.lastname: Aleksandrova
mesh_terms: D000222:Adaptation, Physiological; D001794:Blood Pressure / Q000502:physiology; D004576:Electromyography; D005260:Female; D018475:Head-Down Tilt / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology*; D012132:Respiratory Muscles / Q000502:physiology*; D014939:Work of Breathing / Q000502:physiology