title: [Successful pregnancy in a severely hypoxemic patient with pulmonary alveolar proteinosis].
abstract: Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by abnormal accumulation of a lipoproteinaceous material in the alveoli, which may lead to respiratory failure and has an associated high risk for infections. The mainstay treatment for PAP is whole lung lavage. A pregnant woman, previously diagnosed with primary PAP, the most common form of PAP, was admitted with dyspnea and worsening respiratory function. In one month period, a whole-lung bronchopulmonary lavage was performed twice, with clinical and functional improvement. Pregnancy was carried to term and a healthy baby was delivered. The mechanisms of respiratory impairment are discussed as well as treatment options and response.
authors.affiliation: Pneumologia, Centro Hospitalar do Porto, Hospital de Santo António, Porto, Portugal. inesbelchior@gmail.com
authors.forename: I
authors.initials: I
authors.lastname: Belchior
authors.forename: A S
authors.initials: AS
authors.lastname: Cerdeira
authors.forename: M
authors.initials: M
authors.lastname: Santos
authors.forename: J Sousa
authors.initials: JS
authors.lastname: Braga
authors.forename: I
authors.initials: I
authors.lastname: Aragão
authors.forename: A
authors.initials: A
authors.lastname: Martins
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications*; D012131:Respiratory Insufficiency / Q000209:etiology*; D012720:Severity of Illness Index