title: Does metabolite deficiency mark oncogenic cell cycles?
abstract: Genome instability occurs early in the development of most cancers. Bester et al. now provide evidence that oncogenic signals trigger cell division without coordinate nucleotide synthesis, engendering aberrant DNA replication and damage that could promote carcinogenesis. A mismatch between proliferation and metabolite production may characterize oncogenic cell cycles.
authors.affiliation: University of Cambridge, Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, UK. arv22@hutchison-mrc.cam.ac.uk
authors.forename: Ashok R
authors.initials: AR
authors.lastname: Venkitaraman