title: Involvement of human T lymphotropic virus type I in human neoplasia.
abstract: Of 211 human tissues analyzed by PCR-SSCP and direct sequencing for HTLV-I genes, 165 (78.2%) gave positive signals. Signals detected in family members of adult T cell leukemia (ATL) patients showed mutations distinct from those in ATL. HTLV-I gene sequences showed variability in same persons examined at different times. Lymphocytes with prototypic HTLV-I genes showed higher sister chromatid exchange following MNNG treatment than those without. Nasopharyngeal carcinomas carrying both HTLV-I and Epstein-Barr virus genes showed markedly abnormal gene product expression. HTLV-I genes in human DNA may cause deregulation of host cell genes upon exposure to carcinogens including viruses.
authors.affiliation: CHIBA CANC CTR,RES INST,DIV PATHOL,CHUO KU,CHIBA 260,JAPAN.
authors.forename: K
authors.initials: K
authors.lastname: Maruyama
authors.forename: M
authors.initials: M
authors.lastname: Miyauchi
authors.forename: S
authors.initials: S
authors.lastname: Mochizuki
authors.forename: K
authors.initials: K
authors.lastname: Kawamura
authors.forename: N
authors.initials: N
authors.lastname: Koshikawa