title: Behavioral inhibition is associated with airway hyperresponsiveness but not atopy in a monkey model of asthma.
abstract: OBJECTIVE
  To determine whether indicators of behavioral inhibition and cortisol responses to stressful situations, obtained in infancy, were associated with asthma-related measures (atopy and airway hyperresponsiveness [AHR]) approximately 2 years later.
  
  
  METHODS
  Measures reflecting inhibited temperament and cortisol response after a 25-hour separation from mother and relocation to a novel room were obtained for 21 rhesus monkeys (mean age, 109 days; range, 91-122 days). Inhibited temperament was measured by reduced emotionality and increased vigilance. Atopy and AHR were assessed after 2 years (age range, 19-35 months) using skin tests to common aeroallergens and inhaled methacholine challenge, respectively.
  
  
  RESULTS
  No associations were found between atopy and either behavioral inhibition or cortisol levels (p > .56). Low emotionality was associated with AHR (r = 0.47, p = .03), and a trend was found for blunted cortisol responsiveness and AHR (r = 0.42, p = .06).
  
  
  CONCLUSIONS
  Inhibited temperament and blunted cortisol responsiveness may be related to the development of AHR that is common to both nonatopic and atopic asthma phenotypes and may indicate risk for nonatopic asthma specifically.
authors.affiliation: California National Primate Research Center, University of California, One Shields Ave, Davis, CA 95616, USA. jpcapitanio@ucdavis.edu
authors.forename: John P
authors.initials: JP
authors.lastname: Capitanio
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Miller
authors.forename: Edward S
authors.initials: ES
authors.lastname: Schelegle
authors.forename: Sally P
authors.initials: SP
authors.lastname: Mendoza
authors.forename: William A
authors.initials: WA
authors.lastname: Mason
authors.forename: Dallas M
authors.initials: DM
authors.lastname: Hyde
mesh_terms: D000293:Adolescent; D000818:Animals; D001249:Asthma / Q000097:blood / Q000276:immunology / Q000503:physiopathology / Q000523:psychology*; D001522:Behavior, Animal; D016535:Bronchial Hyperreactivity / Q000097:blood / Q000523:psychology*; D001985:Bronchial Provocation Tests; D002648:Child; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006969:Hypersensitivity, Immediate; D007030:Hypothalamo-Hypophyseal System; D007266:Inhibition, Psychological; D008253:Macaca mulatta; D008297:Male; D010913:Pituitary-Adrenal System; D012044:Regression Analysis; D012882:Skin Tests; D013315:Stress, Psychological / Q000097:blood; D013694:Temperament
chemical_list: D006854:Hydrocortisone