title: Eliciting carbohydrate-specific immune response against sialosides: success and challenges.
abstract: Chemoenzymatic synthesis has been shown to be a powerful adjunct to carbohydrate chemistry since it allows chemists to prepare a wide range of complex carbohydrate analogs in large amounts and with unparalleled efficiency. Here we summarize investigations conducted in our group into the synthesis and immunochemistry of tumor-associated gangliosides and the development of a chemoenzymatic route to α(2→8)-linked oligosialosides by probing substrate binding to the enzyme, α(2→8)-sialyltransferase.
authors.affiliation: Department of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, Alberta T3G 3M9, Canada. ccling@ucalgary.ca
authors.forename: Chang-Chun
authors.initials: CC
authors.lastname: Ling
authors.forename: David R
authors.initials: DR
authors.lastname: Bundle
mesh_terms: D000818:Animals; D005732:Gangliosides / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D008958:Models, Molecular; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D012799:Sialyltransferases / Q000378:metabolism
chemical_list: D005732:Gangliosides; D012799:Sialyltransferases