title: No adverse effects of cyclosporin A on cellular and functional development of foetal rat dopaminergic mesencephalic neurones grafted into the 6-hydroxydopamine rat model of Parkinson's disease.
abstract: This study investigated the potential neurotoxic effects of cyclosporin A (CyA) on allogeneic foetal rat ventral mesencephalic (VM) grafts in the 6-hydroxydopamine rat model of Parkinson's disease. Despite its use in the clinical neural grafting situation, the safety of the CyA treatment concerning graft survival and function has not been demonstrated in systematical animal studies. Three groups of grafted rats were treated with either 10 or 20 mg/kg cylcosporin A daily for 6 weeks. Analysis of graft function and development within the different immunosuppression regimes showed no significant differences between any parameters assessed (rotational behaviour and graft survival). It is concluded that high doses of cyclosporin A do not adversely influence survival and function of rat-to-rat foetal allogeneic VM grafts.
authors.affiliation: Institute of Physiology, Pettenkoferstrasse 12, 80336 Munich, Ludwig-Maximilians University, Munich, Germany.
authors.forename: C D
authors.initials: CD
authors.lastname: Earl
authors.forename: E M
authors.initials: EM
authors.lastname: Frodl
authors.forename: S C
authors.initials: SC
authors.lastname: Pupeter
authors.forename: W H
authors.initials: WH
authors.lastname: Oertel
authors.forename: A
authors.initials: A
authors.lastname: Kupsch