title: Antiplasmodial activity of artecyclopentyl mether a new artemisinin derivative and its effect on pathogenesis in Plasmodium yoelii nigeriensis infected mice.
abstract: In an effort to evaluate novel derivatives from artemisinin, possessing potential antimalarial activity, a new derivative artecyclopentyl mether (CPM-1) was derivatized and evaluated for its dose-dependent efficacy in Plasmodium yoelii nigeriensis infected mice. The survivability of mice at 7.5 mg/kg was >28 days with negligible parasitaemia and recovered anemia (66.16-72.62%). Artecyclopentyl mether was also found to modulate the pro- and anti-inflammatory cytokines (IFN-γ, 39.64-56.92%; TNF, 49.10-74.31%; IL-4, 11.53-43.22%; IL-10, 37.60-53.52%) favourably besides optimizing the oxidative stress to the infected subjects as evident by the nitric oxide (88.76-95.43%), lipid peroxidation (59.30-76.05%) and glycaemic data (62.70-76.66%). The results indicate the potentiality of the new derivative as an antimalarial against asexual stages of the parasite.
authors.affiliation: Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015 Lucknow, India.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Agarwal
authors.forename: Suriya Pratap
authors.initials: SP
authors.lastname: Singh
authors.forename: Debabrata
authors.initials: D
authors.lastname: Chanda
authors.forename: Dnyaneshwar Umrao
authors.initials: DU
authors.lastname: Bawankule
authors.forename: Rajendra Singh
authors.initials: RS
authors.lastname: Bhakuni
authors.forename: Anirban
authors.initials: A
authors.lastname: Pal
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000627:therapeutic use; D037621:Artemisinins / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000627:therapeutic use; D016207:Cytokines / Q000032:analysis / Q000276:immunology; D018432:Drug Resistance, Multiple; D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008288:Malaria / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D051379:Mice; D009569:Nitric Oxide / Q000032:analysis / Q000096:biosynthesis; D018384:Oxidative Stress / Q000187:drug effects; D018512:Parasitemia / Q000188:drug therapy*; D010967:Plasmodium yoelii / Q000187:drug effects* / Q000502:physiology; D012376:Rodent Diseases / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D016207:Cytokines; D009569:Nitric Oxide