title: Preventive surgery is associated with reduced cancer risk and mortality in women with BRCA1 and BRCA2 mutations.
abstract: Women who have inherited mutations in the BRCA1 or BRCA2 (BRCA1/2) genes have a substantially elevated risk of developing breast and ovarian cancer. For more than 10 years, researchers have studied whether preventive surgery (to remove breasts, ovaries, and/or fallopian tubes) can reduce the cancer and mortality risk in BRCA1/2 mutation carriers. This Issue Brief summarizes the results of the latest, largest, multinational study on the effects of preventive surgery in these women. The results are consistent with earlier studies and provide strong evidence for the use of preventive surgery as an effective approach to managing this genetic risk.
authors.affiliation: Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelpha, PA 19104, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Domchek
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Rebbeck
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control / Q000601:surgery*; D005060:Europe; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D008408:Mastectomy; D015201:Meta-Analysis as Topic; D009656:North America; D010051:Ovarian Neoplasms / Q000235:genetics / Q000517:prevention & control / Q000601:surgery*; D010052:Ovariectomy; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein