title: Iron-catalyzed direct alkenylation of 2-substituted azaarenes with N-sulfonyl aldimines via C-H bond activation.
abstract: A novel iron-catalyzed alkenylation of 2-substituted azaarenes through sp(3) C-H bond activation has been developed. A favorable E2-elimination is proposed as a key step to cleavage of C-H and C-N bonds for the construction of a C═C bond in high stereoselectivity. This transformation represents an efficient way to synthesize 2-alkenylated azaarenes from simple starting materials.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P R China.
authors.forename: Bo
authors.initials: B
authors.lastname: Qian
authors.forename: Pan
authors.initials: P
authors.lastname: Xie
authors.forename: Yinjun
authors.initials: Y
authors.lastname: Xie
authors.forename: Hanmin
authors.initials: H
authors.lastname: Huang
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007097:Imines / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000475:Alkenes; D001372:Aza Compounds; D007097:Imines; D013450:Sulfones; D007501:Iron