title: Functional evaluation using multistep registration with standard magnetic resonance and ADAM brain images.
abstract: OBJECTIVE
  Image analysis of 123I ADAM single photon emission computed tomography is used to evaluate the functional activities in apparatus or in the brain regions. We have earlier proposed a two-step registration method for registering intrasubject long-time 2-[(2-((dimethyl-amino) methyl)phenyl)thio]-5-iodophenylamine (ADAM) images. However, this method requires acquisition of individual MRI, 10-min ADAM, and 6-h ADAM images.
  
  
  METHODS
  In this study, we propose using standard (std) brains to replace the individual MRI and 10-min ADAM images. We first use the MRI std instead of the individual MRI. We then use the 10-min ADAM std to replace the individual 10-min ADAM image.
  
  
  RESULTS
  The results produced using the MRI std method are close to the original two-step registration method (specific/nonspecific binding ratio, 4.211 vs. 4.326, P=0.055); and the 10 min ADAM std method is close to the MRI std method (specific/nonspecific binding ratio, 4.095 vs. 4.211, P=0.070).
  
  
  CONCLUSIONS
  The proposed 10-min ADAM std method yields acceptable quantitative measurements and significantly reduces patient loading by eliminating the additional individual MRI and 10-min ADAM imaging. More important, the interobserver problem can be solved because the area of interest (AOI) is drawn on the MRI std once; the AOI drawn on the MRI std can be mapped onto the registered 10-min ADAM std, and the individual 6 h ADAM image can then be automatically evaluated with the AOI on the 10-min ADAM std after the proposed registration. Thus, the examination of 123I ADAM thus becomes less expensive, more convenient, and useful for clinical applications.
authors.affiliation: Department of Computer Science and Information Engineering, University Hospital, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Chung-I
authors.initials: CI
authors.lastname: Huang
authors.forename: Yung-Nien
authors.initials: YN
authors.lastname: Sun
authors.forename: Wei-Jen
authors.initials: WJ
authors.lastname: Yao
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology*; D002928:Cinanserin / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000592:standards*; D008297:Male; D008875:Middle Aged; D012015:Reference Standards; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: C413491:2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine; D002928:Cinanserin