title: Effect of continuous intravenous administration of high-dose G-CSF on hematologic recovery following autologous purged bone marrow transplantation.
abstract: Delay in peripheral blood recovery is a common complication of autologous purged bone marrow transplantation. To overcome this problem, we examined the effect of continuous intravenous administration of high-dose G-CSF on hematologic recovery following autologous bone marrow transplantation (auto-BMT) with purged bone marrow. Continuous intravenous administration of high dose G-CSF significantly facilitated the recovery of platelet counts and reticulocyte counts compared to one-hour bolus intravenous injection of the usual-dose G-CSF, although both ways of administration facilitated the recovery of leukocyte counts. The results showed continuous intravenous administration of high-dose G-CSF was useful to facilitate the recovery of not only leukocytes but also reticulocytes and platelets following auto-BMT with purged bone marrow in certain situations. Continuous i.v. administration of high-dose G-CSF may be one of the safest and most useful modes facilitating the hematopoietic recovery following auto-BMT with purged bone marrow.
authors.affiliation: TOKYO MED & DENT UNIV,FAC MED,DEPT LAB MED,TOKYO 113,JAPAN.
authors.forename: S
authors.initials: S
authors.lastname: Tanikawa
authors.forename: H
authors.initials: H
authors.lastname: Sakamaki
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Onozawa
authors.forename: H
authors.initials: H
authors.lastname: Kaku
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Takamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Adachi
authors.forename: N
authors.initials: N
authors.lastname: Nara