title: Detection of platelet-binding anti-measles and anti-rubella virus IgG antibodies in infants with vaccine-induced thrombocytopenic purpura.
abstract: A 15-month-old infant presented with thrombocytopenic purpura after sequential administration of measles-rubella combined vaccine, varicella vaccine and mumps vaccine every 4 weeks. Her thrombocytopenia persisted for more than 12 months. Both anti-measles and anti-rubella virus IgG antibodies were detected in the patient's-isolated platelets on day 154 of illness, which were not detected when there was a reduction of the serum IgG antibody titers on days 298 and 373 of illness, respectively.We also detected the isolated platelet-binding anti-measles and anti-rubella virus IgG antibodies in two other pediatric patients. This is the first report demonstrating direct evidence of vaccine-induced thrombocytopenic purpura.
authors.affiliation: Department of Pediatrics and Child Neurology, Oita University Faculty of Medicine, Hasama, Yufu, Oita 879-5593, Japan. naho-chi@oita-u.ac.jp
authors.forename: Naho
authors.initials: N
authors.lastname: Okazaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takeguchi
authors.forename: Kohji
authors.initials: K
authors.lastname: Sonoda
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Handa
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kakiuchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyahara
authors.forename: Kensuke
authors.initials: K
authors.lastname: Akiyoshi
authors.forename: Seigo
authors.initials: S
authors.lastname: Korematsu
authors.forename: Soichi
authors.initials: S
authors.lastname: Suenobu
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Izumi
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000378:metabolism; D007223:Infant; D008458:Measles Vaccine / Q000009:adverse effects* / Q000276:immunology; D011485:Protein Binding; D011696:Purpura, Thrombocytopenic / Q000139:chemically induced*; D012411:Rubella Vaccine / Q000009:adverse effects* / Q000276:immunology; D017778:Vaccines, Combined / Q000009:adverse effects / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D008458:Measles Vaccine; D012411:Rubella Vaccine; D017778:Vaccines, Combined