title: Pancreas - non-alcoholic constituents and their effects.
abstract: Alcoholic beverages contain numerous non-alcoholic compounds that could have beneficial or pathological effects. For example, up to now in beer more than 2,000 and in wine more than 1,000 organic and inorganic constituents have been identified. Whereas the role of alcohol (ethanol) in the development of pancreatic diseases - in particular acute and chronic pancreatitis - has been intensively investigated, only little is known about the effects of non-alcoholic compounds in this context. Some of the non-alcoholic constituents have been shown to be biologically active, although discussions of the results in appropriate publications were often not performed with regard to their consumption as a mixture in alcoholic beverages. In this article we provide an overview about the newest data concerning the effect of non-alcoholic constituents of alcoholic beverages, especially of beer, on pancreatic secretion and their possible role in alcoholic pancreatitis. The data indicate that non-alcoholic constituents of beer stimulate pancreatic enzyme secretion in humans and rats, at least in part, by direct action on pancreatic acinar cells. However, there is accumulating evidence that non-alcoholic compounds of alcoholic beverages exert different effects on the pancreas. The effects and mechanisms of most single compounds and their combinations are still unknown and thus caution is required in attempting to draw firm conclusions on the effect of non-alcoholic compounds of alcoholic beverages on defining alcoholic etiology of pancreatitis.
authors.affiliation: Department of Medicine II, University Hospital of Heidelberg at Mannheim, Mannheim, Germany. andreas_gerloff@web.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Gerloff
authors.forename: Peter
authors.initials: P
authors.lastname: Feick
authors.forename: Manfred V
authors.initials: MV
authors.lastname: Singer
mesh_terms: D000434:Alcoholic Beverages / Q000009:adverse effects*; D000818:Animals; D001515:Beer / Q000009:adverse effects; D006801:Humans; D010179:Pancreas / Q000378:metabolism / Q000473:pathology*; D019512:Pancreatitis, Alcoholic / Q000473:pathology; D015398:Signal Transduction