title: Genetic influences on Alzheimer's disease: evidence of interactions between the genes APOE, APOC1 and ACE in a sample population from the South of Brazil.
abstract: Alzheimer's disease is a complex neurodegenerative disorder. Several genes have been suggested as Alzheimer's susceptibility factors, the apolipoprotein E (APOE) gene being an established susceptibility gene and the genes coding angiotensin-converting enzyme (ACE) and apolipoprotein C1 (APOC1) being considered possible candidate genes for the disease. The objective of this study was to investigate the association of ACE and APOC1 gene polymorphisms with susceptibility to Alzheimer's disease and dementia in general, both alone and combined with the APOE gene. Forty-seven patients with dementia in general (35 of them with Alzheimer's disease) and 85 controls were investigated. The haplotypes E*3/-317*ins and E*4/-317*ins of APOE/APOC1 genes were significantly more frequent in the groups with Alzheimer's disease and dementia in general (P < 0.001). The frequency of the ACE*ins allele was also greater in the groups with Alzheimer's disease and dementia in general (P = 0.022; P = 0.045), but genotype frequencies were only different in groups without the E*4/-317*ins haplotype (P = 0.012 for Alzheimer's disease; P = 0.04 for dementia). Our data point to important genetic interactions involved in these diseases.
authors.affiliation: Health Science Institute, Pró-Reitoria de Pesquisa e Inovação, PROPI Sala 201 F, Universidade Feevale, RS 239, No. 2755, B. Vila Nova, Novo Hamburgo, RS, 93352-000, Brazil.
authors.forename: Juliana Fagion
authors.initials: JF
authors.lastname: Lucatelli
authors.forename: Alessandra Chielle
authors.initials: AC
authors.lastname: Barros
authors.forename: Vanessa Kappel da
authors.initials: VK
authors.lastname: Silva
authors.forename: Fernanda da Silva
authors.initials: Fda S
authors.lastname: Machado
authors.forename: Pâmela Camini
authors.initials: PC
authors.lastname: Constantin
authors.forename: Ana Amélia Cipriani
authors.initials: AA
authors.lastname: Dias
authors.forename: Mara Helena
authors.initials: MH
authors.lastname: Hutz
authors.forename: Fabiana Michelsen
authors.initials: FM
authors.lastname: de Andrade
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D053302:Apolipoprotein C-I / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D001938:Brazil; D003704:Dementia / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D053302:Apolipoprotein C-I; D001057:Apolipoproteins E; D007703:Peptidyl-Dipeptidase A