title: Of cancer and cave fish.
abstract: We propose that the drivers of carcinogenesis lie more in the adaptive changes that are enabled by local or systemic alterations of tissue architecture than in the genetic changes observed in cancer cells. A full understanding of cancer biology and therapy through a cataloguing of the cancer genome is unlikely unless it is integrated into an evolutionary and ecological context.
authors.affiliation: Departments of Radiology and Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida 33612, USA. Robert.Gatenby@Moffitt.org
authors.forename: Robert A
authors.initials: RA
authors.lastname: Gatenby
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Gillies
authors.forename: Joel S
authors.initials: JS
authors.lastname: Brown
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology*; D004463:Ecology; D005399:Fishes / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*