title: Clinical predictors of response and remission in inpatients with depressive syndromes.
abstract: BACKGROUND
  Most predictor analyses search for single predictors or rely on data from randomized controlled trials. We aimed at detecting a set of clinical baseline variables for prediction of response and remission in 1014 naturalistically treated inpatients with major depressive episode treated for 53.62 ± 47.5 days.
  
  
  METHODS
  A three-staged procedure was implemented. First, univariate tests were used for finding associations with baseline variables. Second, logistic regression and third-CART analyses were used to determine predictors of response to inpatient treatment.
  
  
  RESULTS
  Presence of suicidality, a higher initial HAMD-21 total score, an episode length <24 months, fewer previous hospitalizations, and absence of any ICD-10F4 comorbidity predicted response in 2 different statistical models. Remission was predicted by lower HAMD-21 baseline score, episode length <24 months and fewer previous hospitalizations in both models.
  
  
  CONCLUSIONS
  Results were assessed by a post-hoc analysis, based on prospectively collected data. No controlled study design.
  
  
  CONCLUSIONS
  Contrary to current beliefs, baseline suicidality might be associated with higher chances for response. In addition, baseline severity might impact outcome depending on which criterion (remission or response) used.
authors.affiliation: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Riedel
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Möller
authors.forename: Michael
authors.initials: M
authors.lastname: Obermeier
authors.forename: Mazda
authors.initials: M
authors.lastname: Adli
authors.forename: Michael
authors.initials: M
authors.lastname: Bauer
authors.forename: Klaus
authors.initials: K
authors.lastname: Kronmüller
authors.forename: Peter
authors.initials: P
authors.lastname: Brieger
authors.forename: Gerd
authors.initials: G
authors.lastname: Laux
authors.forename: Wolfram
authors.initials: W
authors.lastname: Bender
authors.forename: Isabella
authors.initials: I
authors.lastname: Heuser
authors.forename: Joachim
authors.initials: J
authors.lastname: Zeiler
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Gaebel
authors.forename: Rebecca
authors.initials: R
authors.lastname: Schennach-Wolff
authors.forename: Verena
authors.initials: V
authors.lastname: Henkel
authors.forename: Florian
authors.initials: F
authors.lastname: Seemüller
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D012074:Remission Induction; D013406:Suicide, Attempted / Q000523:psychology*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents