title: Constituents from Senecio scandens and their antioxidant bioactivity.
abstract: Forty-one compounds including two new constituents, senecainin A (1) and 3-methoxyisonicotinic acid (2), were characterized from the methanol extracts of the whole plant of Senecio scandens. The structures of the new compounds were comprehensively established with the aid of 1D and 2D NMR spectroscopic and mass spectrometric analyses. The chemical structures of known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literature. In addition, the antioxidant activity of some of the isolates was examined in the DPPH free radical scavenging assay. Among the tested compounds, (-)-monoepoxylignanolide, (-)-pinoresinol and (-)-epi-pinoresinol displayed significant antioxidant bioactivity.
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Yann-Lii
authors.initials: YL
authors.lastname: Leu
authors.forename: Chih-Lung
authors.initials: CL
authors.lastname: Lin
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D003512:Cyclohexanones / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D007539:Isonicotinic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D012674:Senecio / Q000737:chemistry*
chemical_list: C560805:3-methoxyisonicotinic acid; D000975:Antioxidants; D001713:Biphenyl Compounds; D003512:Cyclohexanones; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D005609:Free Radicals; D007539:Isonicotinic Acids; D010851:Picrates; C560804:senecainin A; C004931:1,1-diphenyl-2-picrylhydrazyl