title: An evaluation of the duration of efficacy of emamectin benzoate in the control of Caligus curtus Müller infestations in Atlantic cod, Gadus morhua L.
abstract: The duration of efficacy of emamectin benzoate in the control of Caligus curtus infestations in Atlantic cod, Gadus morhua L., was studied following an administration of 50 μg kg⁻¹ for seven consecutive days. No lice were found on medicated fish when challenged 1 week (challenge 1) or 5 weeks (challenge 2) following termination of medication, whereas the mean abundance of lice among the unmedicated fish was 17.9 and 19.3 lice per fish in challenge 1 and 2, respectively. Muscle concentrations of 19.5 ± 8.2 ng g⁻¹ and 3.4 ± 0.9 ng g⁻¹, respectively, and skin concentrations of 23.1 ± 10.8 and 4.2 ± 1.0 ng g⁻¹, respectively, were found 27 and 55 days following the termination of medication. Tissue concentrations and the duration of efficacy indicate a dosing regime for emamectin in cod, similar to the regime used for Atlantic salmon, Salmo salar L.
authors.affiliation: Institute of Marine Research, Nordnes, Bergen, Norway.
authors.forename: L A
authors.initials: LA
authors.lastname: Hamre
authors.forename: B T
authors.initials: BT
authors.lastname: Lunestad
authors.forename: R
authors.initials: R
authors.lastname: Hannisdal
authors.forename: O B
authors.initials: OB
authors.lastname: Samuelsen
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017756:Aquaculture; D033342:Copepoda / Q000187:drug effects*; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D005393:Fish Diseases / Q000188:drug therapy* / Q000469:parasitology; D048389:Gadus morhua; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009132:Muscles / Q000378:metabolism; D009664:Norway; D012867:Skin / Q000378:metabolism
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin; C108024:emamectin benzoate