title: Combined deletions of pfhrp2 and pfhrp3 genes result in Plasmodium falciparum malaria false-negative rapid diagnostic test.
abstract: We report a case of misdiagnosis of Plasmodium falciparum malaria from Brazil with negative PfHRP2-based rapid diagnostic tests (RDTs), leading to inappropriate case management. Genetic tests showed the deletion of both pfhrp2 and pfhrp3 genes. The detection of two distinct P. falciparum target antigens is then advisable.
authors.affiliation: Laboratoire de Parasitologie, AP-HP, Hôpital Bichat, Paris, France. sandrine.houze@bch.aphp.fr
authors.forename: Sandrine
authors.initials: S
authors.lastname: Houzé
authors.forename: Véronique
authors.initials: V
authors.lastname: Hubert
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Le Pessec
authors.forename: Jacques
authors.initials: J
authors.lastname: Le Bras
authors.forename: Jérôme
authors.initials: J
authors.lastname: Clain
mesh_terms: D000328:Adult; D000953:Antigens, Protozoan / Q000235:genetics*; D001938:Brazil; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005188:False Negative Reactions; D006801:Humans; D016778:Malaria, Falciparum / Q000175:diagnosis* / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000235:genetics / Q000302:isolation & purification*; D015800:Protozoan Proteins / Q000235:genetics; D017384:Sequence Deletion
chemical_list: D000953:Antigens, Protozoan; C514457:HRP-2 antigen, Plasmodium falciparum; D015800:Protozoan Proteins