title: Static and dynamic (18) FDG-PET in normal hispaniolan Amazon parrots (Amazona ventralis).
abstract: Positron emission tomography (PET) is often used to stage and monitor human cancer and has recently been used in a similar fashion in veterinary medicine. The most commonly used radiopharmaceutical is 2-Deoxy-2-[(18) F]-Fluoro-d-glucose ((18) F-FDG), which is concentrated and trapped within cells that use glucose as their energy substrate. We characterized the normal distribution of (18) F-FDG in 10 healthy Hispaniolan Amazon parrots (Amazona ventralis) by performing whole body PET scans at steady state, 60min after injection. Significant variability was found in the intestinal activity. Avian species are known to reflux fluid and electrolytes from their cloaca into their colon. To evaluate reflux as the cause of variability in intestinal distribution of (18) F-FDG, dynamic PET scans were performed on the coelomic cavity of six Hispaniolan Amazon parrots from time 0 to 60min postinjection of radiotracer. Reflux of radioactive material from the cloaca into the colon occurred in all birds to varying degrees and occurred before 60min. To evaluate the intestinal tract of clinical avian patients, dynamic scans must be performed starting immediately after injection so that increased radioactivity due to metabolism or hypermetabolic lesions such as cancer can be differentiated from increased radioactivity due to reflux of fluid from the cloaca.
authors.affiliation: Department of Comparative Medicine, University of Tennessee, College of Veterinary Medicine, Knoxville, TN 37996, USA.
authors.forename: Marcy J
authors.initials: MJ
authors.lastname: Souza
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Wall
authors.forename: Alan
authors.initials: A
authors.lastname: Stuckey
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Daniel
mesh_terms: D046708:Amazona; D000818:Animals; D005260:Female; D019788:Fluorodeoxyglucose F18; D008297:Male; D049268:Positron-Emission Tomography / Q000662:veterinary*; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18