title: Ancestry of African Americans with sickle cell disease.
abstract: The inheritance of genetic disease depends on ancestry that must be considered when interpreting genetic association studies and can provide insights when comparing traits in a population. We compared the genetic profiles of African Americans with sickle cell disease to those of Black Africans and Caucasian populations of European descent and found that they are less genetically admixed than other African Americans and have an ancestry similar to Yorubans, Mandenkas and Bantu.
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. ntimofee@bu.edu
authors.forename: Nadia
authors.initials: N
authors.lastname: Solovieff
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Hartley
authors.forename: Clinton T
authors.initials: CT
authors.lastname: Baldwin
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Klings
authors.forename: Mark T
authors.initials: MT
authors.lastname: Gladwin
authors.forename: James G
authors.initials: JG
authors.lastname: Taylor
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Kato
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Farrer
authors.forename: Martin H
authors.initials: MH
authors.lastname: Steinberg
authors.forename: Paola
authors.initials: P
authors.lastname: Sebastiani
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000755:Anemia, Sickle Cell / Q000208:ethnology* / Q000235:genetics*; D016000:Cluster Analysis; D030541:Databases, Genetic; D005006:Ethnicity / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics