title: Effects of human growth hormone on peripheral nerve regeneration.
abstract: Systemic administration of human growth hormone (hGH) to intact or hypophysectomized rats was found to stimulate regeneration of the crush-lesioned sciatic nerve. The IGF-I levels of serum of the treated rats did not correlate with regeneration of the nerve but hGH treatment increased the IGF-I content of the nerve. The results suggest that a GH-mediated increase of IGF-I in the sciatic nerve could be involved in the stimulatory effect of GH on neurite outgrowth.
authors.affiliation: Kabi Peptide Hormones, Stockholm (Sweden).
authors.forename: A
authors.initials: A
authors.lastname: Skottner
authors.forename: M
authors.initials: M
authors.lastname: Kanje
authors.forename: V
authors.initials: V
authors.lastname: Arrhenius-Nyberg
authors.forename: G
authors.initials: G
authors.lastname: Lundborg