title: Integrin targeted delivery of radiotherapeutics.
abstract: Targeted radionuclide therapy, which is based on the selective delivery of a sufficient radiation dose to tumors without significantly affecting normal tissues, is a promising therapeutic approach for the treatment of a wide variety of malignancies. Integrins, a family of cell adhesion molecules, play key roles during tumor angiogenesis and metastasis. Among all the integrins, αvβ3 seems to be the most important in the process of tumor angiogenesis. Integrin αvβ3 is highly expressed on activated endothelial cells, new-born vessels as well as some tumor cells, but is not present in resting endothelial cells and most normal organ systems, making it a suitable target for anti-tumor therapy. In this review, we summarize the current development and applications of antibody-, peptide-, and other ligand-based integrin targeted radiotherapeutics for tumor radiation therapy.
authors.affiliation: 1. Medical Isotopes Research Center, Peking University, Beijing, China.
authors.forename: Zhaofei
authors.initials: Z
authors.lastname: Liu
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen