title: Anthropometric, dietary, and hormonal correlates of serum adiponectin in Asian American women.
abstract: There is increasing evidence that adiponectin has a critical role in the development of breast cancer, but factors that influence adiponectin concentrations have not been well studied. We conducted a cross-sectional study among Asian-American controls who participated in a population-based case-control study of breast cancer. Participants were interviewed in-person and donated a blood specimen. Using multivariate models, we investigated the relationships between serum adiponectin concentrations and lifestyle factors (including adiposity and dietary factors) and serum sex-hormones and growth factors among postmenopausal women who were nonhormone-users at blood draw (n = 196). Adiponectin concentrations were significantly positively associated with green tea intake (P trend = 0.03); levels were 31% higher among those who drank green tea 4 or more times per wk (14.5 ± 1.10 μg/mL) compared with nongreen-tea-drinkers (11.0 ± 1.09 μg/mL); this association remained after adjustment for body mass index (BMI) and waist/hip ratio (WHR), both of which were significantly and inversely associated with adiponectin. Adiponectin concentrations were positively associated with sex-hormone-binding globulin (P trend < 0.0001) and the ratios of total testosterone (T)/total estradiol (E2) (P trend <0.004) after adjustment for BMI and WHR. Confirmation of our findings on green tea and adiponectin is needed.
authors.affiliation: Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA. annawu@usc.edu
authors.forename: Anna H
authors.initials: AH
authors.lastname: Wu
authors.forename: Mimi C
authors.initials: MC
authors.lastname: Yu
authors.forename: Frank Z
authors.initials: FZ
authors.lastname: Stanczyk
authors.forename: Chiu-Chen
authors.initials: CC
authors.lastname: Tseng
authors.forename: Malcolm C
authors.initials: MC
authors.lastname: Pike
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050154:Adiposity; D000368:Aged; D001213:Asian; D015992:Body Mass Index; D001943:Breast Neoplasms; D002140:California; D003430:Cross-Sectional Studies; D004032:Diet; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008019:Life Style; D008875:Middle Aged; D015999:Multivariate Analysis; D018570:Risk Assessment; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013662:Tea; D013739:Testosterone / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D052242:Adiponectin; D012738:Sex Hormone-Binding Globulin; D013662:Tea; D013739:Testosterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I