title: Chondromyxoid fibroma of the nasal septum: case report and review of literature.
abstract: BACKGROUND
  Chondromyxoid fibroma (CMF) is a rare bone tumor, accounting for less than 0.5% of all bone tumors, with a predilection for lower extremity bone metaphyses. Involvement of the head and neck is extremely rare, with only 3 cases reported in the nasal septum in world literature.
  
  
  METHODS
  This is a case report of a CMF in the nasal septum of a 49-year-old woman with a 6-month history of congestion. MRI showed a bilobed mass originating from the nasal septum. Histologic and immunoperoxidase staining as well as electron microscopic studies were performed. A literature review was performed.
  
  
  RESULTS
  The patient underwent a midface-degloving approach for surgical resection. The final pathology was prototypic of CMF. The patient was disease-free 16 months postoperatively.
  
  
  CONCLUSIONS
  CMF is a rare, benign neoplasm occasionally occurring in the head and neck. Surgical resection is often curative. CMF must be differentiated from chondrosarcoma, given the substantial differences in treatment.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Medical Center, Division of Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA.
authors.forename: Stanley W
authors.initials: SW
authors.lastname: McClurg
authors.forename: Marino
authors.initials: M
authors.lastname: Leon
authors.forename: Theodoros N
authors.initials: TN
authors.lastname: Teknos
authors.forename: O Hans
authors.initials: OH
authors.lastname: Iwenofu
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery; D002812:Chondroma / Q000473:pathology* / Q000601:surgery; D005260:Female; D005350:Fibroma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009300:Nasal Septum / Q000473:pathology* / Q000601:surgery; D009669:Nose Neoplasms / Q000473:pathology*