title: The anabolic response to resistance exercise and a protein-rich meal is not diminished by age.
abstract: OBJECTIVE
  The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age.
  
  
  METHODS
  The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas.
  
  
  METHODS
  Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults.
  
  
  METHODS
  Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum).
  
  
  METHODS
  Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 µmol/kg) constant infusion (0.08 µmol∙kg(-1)min(-1)) of L- [ring-13C6] phenylalanine.
  
  
  RESULTS
  Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073±0.008; post: 0.156±0.021(SE) %/h, p<0.001] and older adults (pre: 0.075±0.004; post: 0.152±0.017 %/h, p=0.003) following the meal and resistance exercise bout.
  
  
  CONCLUSIONS
  Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.
authors.affiliation: Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, Texas 77555-1144, USA.
authors.forename: T B
authors.initials: TB
authors.lastname: Symons
authors.forename: M
authors.initials: M
authors.lastname: Sheffield-Moore
authors.forename: M M
authors.initials: MM
authors.lastname: Mamerow
authors.forename: R R
authors.initials: RR
authors.lastname: Wolfe
authors.forename: D
authors.initials: D
authors.lastname: Paddon-Jones
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001706:Biopsy; D004044:Dietary Proteins / Q000494:pharmacology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008460:Meat; D009124:Muscle Proteins / Q000096:biosynthesis*; D010649:Phenylalanine / Q000378:metabolism; D052097:Quadriceps Muscle / Q000378:metabolism* / Q000502:physiology; D055070:Resistance Training
chemical_list: D004044:Dietary Proteins; D009124:Muscle Proteins; D010649:Phenylalanine