title: Radioimmunolymphoscintigraphy in the preoperative staging of primary breast cancer.
abstract: Thirty-one primary breast cancer patients were evaluated by radioimmunolymphoscintigraphy (RILS) and ex vivo scintigraphy (EVS) following subcutaneous injection of human monoclonal antibody In-111-LiLo-16.88. Lymph nodes (370) were assessed by EVS, pathology and immunohistochemistry. The positive predictive value (EVS) for antigen positive nodes, metastatic and hyperplastic, was 90% in stages O-IIB, and the sensitivity and specificity for all stages were 60% and 80% respectively. Four EVS positive nodes with follicular hyperplasia contained micrometastases. RILS and EVS correlate well by the Spearman Rank test (R=0.87). These results suggest RILS may be clinically useful and selectively limit the extent of the surgical procedure.
authors.affiliation: PERIMMUNE INC,ROCKVILLE,MD 20850.
authors.forename: A
authors.initials: A
authors.lastname: Pecking
authors.forename: F
authors.initials: F
authors.lastname: Gougeonbertrand
authors.forename: F
authors.initials: F
authors.lastname: Lokiec
authors.forename: J
authors.initials: J
authors.lastname: Murray
authors.forename: R
authors.initials: R
authors.lastname: Subramanian
authors.forename: A
authors.initials: A
authors.lastname: Boudinet
authors.forename: J
authors.initials: J
authors.lastname: Floiras
authors.forename: M
authors.initials: M
authors.lastname: Haspel
authors.forename: J
authors.initials: J
authors.lastname: Klein
authors.forename: S
authors.initials: S
authors.lastname: Shaban
authors.forename: R
authors.initials: R
authors.lastname: Dejager
authors.forename: M
authors.initials: M
authors.lastname: Hanna