title: Influence of estrogen deficiency on bone around osseointegrated dental implants: an experimental study in the rat jaw model.
abstract: OBJECTIVE
  The aim of this study was to evaluate the influence of estrogen deficiency on bone around osseointegrated dental implants in a rat jaw model.
  
  
  METHODS
  This study used 16 female rats that had the first molars bilaterally extracted and were allowed to heal for 30 days before implant placement. Sixty days after implant placement, the animals were randomly subjected to sham surgery or ovariectomy (OVX). The animals were euthanized 90 days after OVX. Bone-to-implant contact, bone area fraction occupancy between implant threads, mineral density, turnover markers, and cells positive for tartrate-resistant acid phosphatase were assessed for the 2 groups.
  
  
  RESULTS
  The results showed that OVX group presented a decrease of systemic bone density, alterations in bone turnover markers, and an increase of cells positive for tartrate-resistant acid phosphatase compared with the sham-surgery group. However, no difference relative to bone-to-implant contact and bone area fraction occupancy was observed between groups.
  
  
  CONCLUSIONS
  The findings of this study demonstrate that estrogen deficiency may not be considered a risk factor for osseointegrated implant failure in jaw bone.
authors.affiliation: Department of Oral Diagnosis and Surgery, Araraquara Dental School, UNESP-Univ Estadual Paulista, Araraquara, São Paulo, Brazil. gabi.giro@gmail.com
authors.forename: Gabriela
authors.initials: G
authors.lastname: Giro
authors.forename: Paulo G
authors.initials: PG
authors.lastname: Coelho
authors.forename: Roberto
authors.initials: R
authors.lastname: Sales-Pessoa
authors.forename: Rosa Maria Rodrigues
authors.initials: RM
authors.lastname: Pereira
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Kawai
authors.forename: Silvana Regina Perez
authors.initials: SR
authors.lastname: Orrico
mesh_terms: D015502:Absorptiometry, Photon; D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000032:analysis / Q000097:blood; D000818:Animals; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000502:physiology*; D024042:Collagen Type I / Q000097:blood; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D007527:Isoenzymes / Q000097:blood; D008437:Maxilla / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016348:Osseointegration / Q000502:physiology*; D015675:Osteocalcin / Q000032:analysis; D010010:Osteoclasts / Q000473:pathology; D053244:Osteoprotegerin / Q000097:blood; D010052:Ovariectomy; D010455:Peptides / Q000097:blood; D053245:RANK Ligand / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties; D000071681:Tartrate-Resistant Acid Phosphatase; D013997:Time Factors
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D015921:Dental Implants; D004967:Estrogens; D007527:Isoenzymes; D053244:Osteoprotegerin; D010455:Peptides; D053245:RANK Ligand; C506032:Tnfrsf11b protein, rat; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase