title: Novel chiral skeletons for drug discovery: antibacterial tetramic acids.
abstract: Modification of the ring nucleus of tetramic acids derived from serine gives chiral heterocyclic libraries that exhibit antibacterial activity, and correlation with various physicochemical parameters indicates that chiral tetramic acids may provide a potentially valuable non-aromatic skeleton for fragment-based drug discovery.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Chloe A
authors.initials: CA
authors.lastname: Holloway
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Matthews
authors.forename: Yong-Chul
authors.initials: YC
authors.lastname: Jeong
authors.forename: Mark G
authors.initials: MG
authors.lastname: Moloney
authors.forename: Christine F
authors.initials: CF
authors.lastname: Roberts
authors.forename: Muhammad
authors.initials: M
authors.lastname: Yaqoob
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D055808:Drug Discovery; D004926:Escherichia coli / Q000187:drug effects; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D040141:Staphylococcaceae / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones; C009435:tetramic acid