title: Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand.
abstract: Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.
authors.affiliation: Shoklo Malaria Research Unit, PO Box 46 Mae Sot, Tak 63110, Thailand. marcus@shoklo-unit.com
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Rijken
authors.forename: Machteld E
authors.initials: ME
authors.lastname: Boel
authors.forename: Bruce
authors.initials: B
authors.lastname: Russell
authors.forename: Mallika
authors.initials: M
authors.lastname: Imwong
authors.forename: Mara L
authors.initials: ML
authors.lastname: Leimanis
authors.forename: Aung Pyae
authors.initials: AP
authors.lastname: Phyo
authors.forename: Atis
authors.initials: A
authors.lastname: Muehlenbachs
authors.forename: Niklas
authors.initials: N
authors.lastname: Lindegardh
authors.forename: Rose
authors.initials: R
authors.lastname: McGready
authors.forename: Laurent
authors.initials: L
authors.lastname: Rénia
authors.forename: Georges
authors.initials: G
authors.lastname: Snounou
authors.forename: Pratap
authors.initials: P
authors.lastname: Singhasivanon
authors.forename: François
authors.initials: F
authors.lastname: Nosten
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D016054:DNA, Protozoan / Q000235:genetics; D004351:Drug Resistance; D005260:Female; D005838:Genotype; D006801:Humans; D016780:Malaria, Vivax / Q000150:complications / Q000469:parasitology*; D021261:Parasitic Sensitivity Tests; D010966:Plasmodium vivax / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000469:parasitology*; D013785:Thailand
chemical_list: D000962:Antimalarials; D016054:DNA, Protozoan; D002738:Chloroquine