title: Production of tgf-Beta and hgf receptor by a differentiated papillary thyroid-carcinoma cell-line (B-cpap) - implication in malignancy.
abstract: The B-CPAP cell line was obtained from a human differentiated papillary thyroid carcinoma. Previous studies showed that the cells present thyroid characteristics such as thyroglobulin production, phenotypic alterations such as synthesis of human chorionic gonadotropin hormone (HCG), expression of neuron specific enolase (NSE) and protein S100, and also somatic mutations of p53 and K-rns oncogenes. The present data further characterize this cell line and show an overexpression of transforming growth factor (TGF beta 1) and c-met gene product i.e. the receptor for human growth factor (HGF). The relation between the phenotypic and somatic alterations in the process of malignancy are discussed.
authors.affiliation: HOP DEBROUSSE,INRA,INSERM,U307,F-69332 LYON,FRANCE. LYON SUD MED SCH,CNRS,INSERM,U189,F-69921 OULLINS,FRANCE. UNIV REGGIO CALABRIA,FAC MED & CHIRURG CATANZARO,DIPARTIMENTO MED SPERIMENTALE & CLIN,I-88100 CATANZARO,ITALY.
authors.forename: C
authors.initials: C
authors.lastname: Paulin
authors.forename: O
authors.initials: O
authors.lastname: Avallet
authors.forename: F
authors.initials: F
authors.lastname: Tardy
authors.forename: J
authors.initials: J
authors.lastname: Saez
authors.forename: A
authors.initials: A
authors.lastname: Fusco
authors.forename: N
authors.initials: N
authors.lastname: Fabien