title: Synthesis of dicationic diaryltriazines nucleic acid binding agents.
abstract: - The synthesis of 2,4-bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-1,3,5-triazine 6a and 2,4-bis[4-(1,4,5,6-tetrahydropyrimidin-2-yl)phenyl]-1,3,5-triazine 6b in 3 steps from either 4-bromobenzamidine or 4-(carbamoyl)benzamidine is reported. The synthesis of 4,6-bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-dimethylamino-1,3,5-triazine 9a and 4,6-bis[4-(1,4,5,6-tetrahydropyrimidin-2-yl)phenyl]-2-dimethylamino-1,3,5-triazine 9b in 2 steps from 1,4-dicyanobenzene is also described. The compounds 6b and 9b bind strongly to DNA model sequences and inhibit topoisomerase II from 2 microbial sources. Compounds 6a and 9a bind to both DNA and RNA model sequences whereas 6b and 9b essentially do not bind to the RNA model.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303.
authors.forename: J
authors.initials: J
authors.lastname: Spychala
authors.forename: Dw
authors.initials: D
authors.lastname: Boykin
authors.forename: Wd
authors.initials: W
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Zhao
authors.forename: Rr
authors.initials: R
authors.lastname: Tidwell
authors.forename: Cc
authors.initials: C
authors.lastname: Dykstra
authors.forename: Je
authors.initials: J
authors.lastname: Hall
authors.forename: Sk
authors.initials: S
authors.lastname: Jones
authors.forename: Rf
authors.initials: R
authors.lastname: Schinazi