title: Idiopathic calcinosis cutis in a child: chemical composition of the calcified deposits.
abstract: Idiopathic calcinosis cutis (CC) is a rare disease in a child. The chemical composition of the calcified deposits in idiopathic CC was first qualitatively and quantitatively examined using vibrational microspectroscopy via spectral diagnosis. The combined application of the Fourier transform infrared (FT-IR) and Raman microscopic techniques was used to detect and identify the nature of the components of the calcified deposits in idiopathic CC and to compare the results with histopathological findings. Two major components of type B carbonated apatite and β-carotene interspersing subcutaneous tissue were clearly evidenced to make up the calcified deposits in idiopathic CC in our pediatric patient. Moreover, the calcified deposits of idiopathic CC contained a relatively larger amount of type B carbonated apatite and a smaller amount of type A carbonated apatite than the calcified deposits analyzed in dystrophic CC. This is the first report on the chemical composition of calcified deposits in idiopathic CC established by spectral analysis. The combination of FT-IR and Raman microscopic techniques was very useful for simultaneous assessment of the intact components of the calcified deposits in idiopathic CC.
authors.affiliation: Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
authors.forename: Dau-Ming
authors.initials: DM
authors.lastname: Niu
authors.forename: Shan-Yang
authors.initials: SY
authors.lastname: Lin
authors.forename: Mei-Jane
authors.initials: MJ
authors.lastname: Li
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Cheng
authors.forename: Chin-Chen
authors.initials: CC
authors.lastname: Pan
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Lin
mesh_terms: D002114:Calcinosis / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D012867:Skin / Q000737:chemistry / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D019207:beta Carotene
chemical_list: D019207:beta Carotene