title: Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump.
abstract: Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)(LC) gene not previously described in S. aureus. The native plasmids carrying vga(A)(LC) were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates.
authors.affiliation: Microbiology Laboratory, A9601, Seattle Children's Hospital, 4800 Sand Point Way, NE, Seattle, WA 98105, USA. xuan.qin@seattlechildrens.org
authors.forename: Xuan
authors.initials: X
authors.lastname: Qin
authors.forename: Brian
authors.initials: B
authors.lastname: Poon
authors.forename: Justin
authors.initials: J
authors.lastname: Kwong
authors.forename: Denver
authors.initials: D
authors.lastname: Niles
authors.forename: Byron Z
authors.initials: BZ
authors.lastname: Schmidt
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Rajagopal
authors.forename: Soren
authors.initials: S
authors.lastname: Gantt
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D002675:Child, Preschool; D002981:Clindamycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D018461:Soft Tissue Infections / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology*; D013207:Staphylococcal Skin Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D025364:Streptogramin A / Q000494:pharmacology
chemical_list: D018528:ATP-Binding Cassette Transporters; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C075964:VgA protein, Staphylococcus aureus; D002981:Clindamycin; D004917:Erythromycin; D025364:Streptogramin A