title: The many faces of tau.
abstract: While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.
authors.affiliation: Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
authors.forename: Meaghan
authors.initials: M
authors.lastname: Morris
authors.forename: Sumihiro
authors.initials: S
authors.lastname: Maeda
authors.forename: Keith
authors.initials: K
authors.lastname: Vossel
authors.forename: Lennart
authors.initials: L
authors.lastname: Mucke
mesh_terms: D000818:Animals; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D016875:tau Proteins / Q000502:physiology*
chemical_list: D016875:tau Proteins