title: Investigation of the association between SLC1A3 gene polymorphisms and normal tension glaucoma.
abstract: OBJECTIVE
  To investigate whether the solute carrier family 1, member 3 (SLC1A3) gene, which encodes the glutamate aspartate transporter, is associated with normal tension glaucoma (NTG) in Japanese patients.
  
  
  METHODS
  Two hundred and ninety-five Japanese patients with NTG and 518 Japanese healthy controls were recruited. Patients exhibiting comparatively early NTG onset were selected because early onset suggests that genetic factors may show stronger involvement. We genotyped 5 single-nucleotide polymorphisms (SNPs) in SLC1A3 and assessed the allelic and genotypic diversity among cases and controls.
  
  
  RESULTS
  There were no statistically significant differences in the frequency of SLC1A3 alleles and genotypes between cases and controls.
  
  
  CONCLUSIONS
  Our study showed no association between SLC1A3 and NTG, suggesting that the SLC1A3 gene may not be an associated factor in NTG pathogenesis.
authors.affiliation: Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Yasumura
authors.forename: Akira
authors.initials: A
authors.lastname: Meguro
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nomura
authors.forename: Riyo
authors.initials: R
authors.lastname: Uemoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Kashiwagi
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Mabuchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iijima
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Kawase
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamura
authors.forename: Akira
authors.initials: A
authors.lastname: Negi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sagara
authors.forename: Teruo
authors.initials: T
authors.lastname: Nishida
authors.forename: Masaru
authors.initials: M
authors.lastname: Inatani
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Tanihara
authors.forename: Makoto
authors.initials: M
authors.lastname: Aihara
authors.forename: Makoto
authors.initials: M
authors.lastname: Araie
authors.forename: Takeo
authors.initials: T
authors.lastname: Fukuchi
authors.forename: Haruki
authors.initials: H
authors.lastname: Abe
authors.forename: Tomomi
authors.initials: T
authors.lastname: Higashide
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanamoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiuchi
authors.forename: Aiko
authors.initials: A
authors.lastname: Iwase
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Mizuki
mesh_terms: D000328:Adult; D017668:Age of Onset; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016172:DNA Fingerprinting; D027341:Excitatory Amino Acid Transporter 1 / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D057066:Low Tension Glaucoma / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D027341:Excitatory Amino Acid Transporter 1; C493394:SLC1A3 protein, human