title: [Advances in the study of the differentiation of stem cells into male gametes].
abstract: male gametes play a critical role in transmitting hereditary information to the offspring. Gametogenesis, especially spermatogenesis, is a complicated differentiation process including mitosis and meiosis. However, for lack of an efficient and reproducible model, the mechanism of male germ development is not yet clear. Researches on stem cells'differentiation into male gametes in vitro will promote the study of germ cell development and even reproductive biology. This article updates the researches on the culture of primordial germ cells and stem cells' differentiation into male gametes.
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Laboratory for Sperm Development and Genetics, Shanghai Institute of Andrology, Shanghai Human Sperm Bank, Shanghai 200001, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Hu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
mesh_terms: D018929:Cell Culture Techniques; D002454:Cell Differentiation; D005854:Germ Cells / Q000166:cytology*; D006801:Humans; D008297:Male; D013234:Stem Cells / Q000166:cytology*