title: Efficacy of tube feeding in binge-eating/vomiting patients: a 2-month randomized trial with 1-year follow-up.
abstract: BACKGROUND
  In many binge-eating/vomiting patients, abstinence could not be obtained from classical treatments. Since the authors showed that tube feeding (TF) reduced such episodes in anorexia nervosa (AN)-hospitalized patients, they carried out a randomized trial on the efficacy of TF plus cognitive behavioral therapy (CBT) vs CBT alone in AN and bulimia nervosa adult outpatients.
  
  
  METHODS
  The authors randomly assigned 103 ambulatory patients to receive 16 sessions of CBT alone (n = 51) or CBT plus 2 months of TF (n = 52). The main goal was abstinence of binge-eating/vomiting episodes. Other criteria were gains in fat-free mass and muscle mass improvements in nutrition markers, and quality of life (SF-36 Health Survey), depression (Beck Depression Inventory), and anxiety (Hamilton Anxiety Rating Scale) scores. Evaluations were performed at 1, 2 (end of treatment), 5, 8, and 14 months (analysis of variance).
  
  
  RESULTS
  TF patients were rapidly and more frequently abstinent at the end of treatment (2 months) than the CBT patients: 81% vs 29% (P < .001). Fat-free mass, biological markers, depressive state (-58% vs -26%), anxiety (-48% vs -15%), and quality of life (+42% vs +13%) were more improved in the TF group than in the CBT group (P < .05). One year later, more TF patients remained abstinent (68% vs 27%, P = .02); they were less anxious, were less depressed, and had better quality of life than the CBT patients (P < .05).
  
  
  CONCLUSIONS
  TF combined with CBT offered better results than CBT alone.
authors.affiliation: Nutrition Unit, Endocrinology, CHU Dijon, France. daniel.rigaud@chu-dijon.fr
authors.forename: Daniel Jacques
authors.initials: DJ
authors.lastname: Rigaud
authors.forename: Véronique
authors.initials: V
authors.lastname: Brayer
authors.forename: Anne
authors.initials: A
authors.lastname: Roblot
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Brindisi
authors.forename: Bruno
authors.initials: B
authors.lastname: Vergès
mesh_terms: D000328:Adult; D001007:Anxiety; D015415:Biomarkers / Q000032:analysis; D001825:Body Fluid Compartments; D002032:Bulimia / Q000523:psychology / Q000628:therapy*; D052018:Bulimia Nervosa / Q000523:psychology / Q000628:therapy*; D015928:Cognitive Behavioral Therapy; D003863:Depression; D004750:Enteral Nutrition; D006801:Humans; D018482:Muscle, Skeletal; D011788:Quality of Life; D016896:Treatment Outcome; D014839:Vomiting / Q000453:epidemiology / Q000523:psychology / Q000628:therapy*; D055815:Young Adult
chemical_list: D015415:Biomarkers