title: Resistance-related proteins in initial and relapsed childhood acute lymphoblastic leukemia.
abstract: One hundred and eleven children with initial ALL and 28 children with relapsed ALL were analyzed immunohistochemically for expression of resistance-related proteins. P-glycoprotein (P-170) was found in 35% (initial ALL) vs 54% (relapsed ALL; p=0.07), glutathione S-transferase-pi (GST) in 49% vs 68% (p=0.07), thymidylate-synthase (TS) in 42% vs 64% (p=0.03), dihydrofolate-reductase (DHFR) in 20% vs 32% and metallothionein (MT) in 33% vs 32% of the cases. In initial ALL, the resistance proteins P-170 and GST were expressed more frequently in patients who relapsed under therapy and the frequency was similar to relapsed ALL. These results indicate that P-170 and GST-pi were already present before treatment. In contrast, expression of TS increased during treatment.
authors.affiliation: UNIV JENA,CHILDRENS HOSP,O-6900 JENA,GERMANY.
authors.forename: M
authors.initials: M
authors.lastname: Volm
authors.forename: F
authors.initials: F
authors.lastname: Zintl
authors.forename: A
authors.initials: A
authors.lastname: Sauerbrey