title: Light-induced changes of the circadian clock of humans: increasing duration is more effective than increasing light intensity.
abstract: OBJECTIVE
  To evaluate the effect of increasing the intensity and/or duration of exposure on light-induced changes in the timing of the circadian clock of humans.
  
  
  METHODS
  Multifactorial randomized controlled trial, between and within subject design
  
  
  METHODS
  General Clinical Research Center (GCRC) of an academic medical center
  
  
  METHODS
  56 healthy young subjects (20-40 years of age)
  
  
  METHODS
  Research subjects were admitted for 2 independent stays of 4 nights/3 days for treatment with bright or dim-light (randomized order) at a time known to induce phase delays in circadian timing. The intensity and duration of the bright light were determined by random assignment to one of 9 treatment conditions (duration of 1, 2, or 3 hours at 2000, 4000, or 8000 lux).
  
  
  RESULTS
  Treatment-induced changes in the dim light melatonin onset (DLMO) and dim light melatonin offset (DLMOff) were measured from blood samples collected every 20-30 min throughout baseline and post-treatment nights. Comparison by multi-factor analysis of variance (ANOVA) of light-induced changes in the time of the circadian melatonin rhythm for the 9 conditions revealed that changing the duration of the light exposure from 1 to 3 h increased the magnitude of light-induced delays. In contrast, increasing from moderate (2,000 lux) to high (8,000 lux) intensity light did not alter the magnitude of phase delays of the circadian melatonin rhythm.
  
  
  CONCLUSIONS
  Results from the present study suggest that for phototherapy of circadian rhythm sleep disorders in humans, a longer period of moderate intensity light may be more effective than a shorter exposure period of high intensity light.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Baylor College of Medicine, Houston, TX , USA.
authors.forename: Karuna
authors.initials: K
authors.lastname: Dewan
authors.forename: Susan
authors.initials: S
authors.lastname: Benloucif
authors.forename: Kathryn
authors.initials: K
authors.lastname: Reid
authors.forename: Lisa F
authors.initials: LF
authors.lastname: Wolfe
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Zee
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000528:radiation effects; D002940:Circadian Rhythm / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008550:Melatonin / Q000097:blood; D010789:Phototherapy / Q000379:methods*; D013997:Time Factors; D055815:Young Adult
chemical_list: D008550:Melatonin