title: The use of subcutaneous glycopyrrolate in the management of sialorrhoea and facilitating the use of non-invasive ventilation in amyotrophic lateral sclerosis.
abstract: Sialorrhoea is a recognized complication of bulbar amyotrophic lateral sclerosis (ALS) that leads to an increased risk of potentially harmful aspiration and often prevents patients from tolerating non-invasive ventilation (NIV). A case of treatment-resistant sialorrhoea in bulbar ALS is described where subcutaneous glycopyrrolate was effective without significant side-effects. The patient went on to markedly increase the length of time she could tolerate NIV each night.
authors.affiliation: Academic Unit of Neurology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK. j.cooperknock@sheffield.ac.uk
authors.forename: Johnathan
authors.initials: J
authors.lastname: Cooper-Knock
authors.forename: Sam H
authors.initials: SH
authors.lastname: Ahmedzai
authors.forename: Pamela
authors.initials: P
authors.lastname: Shaw
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007279:Injections, Subcutaneous; D008875:Middle Aged; D012798:Sialorrhea / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome; D014691:Ventilation / Q000379:methods*
chemical_list: D006024:Glycopyrrolate