title: Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosome.
abstract: This report summarizes highlights of the Philadelphia Chromosome Symposium: Past, Present and Future, held September 28, 2010, to commemorate the 50th anniversary of the discovery of the Philadelphia chromosome. The symposium sessions included presentations by investigators who made seminal contributions concerning the discovery and molecular characterization of the Ph chromosome and others who developed a highly successful therapy based on the specific molecular alteration observed in chronic myeloid leukemia. Additional presentations highlighted future opportunities for the design of molecularly targeted therapies for various types of cancer. Also included here are reminiscences connected with the discovery of the Ph chromosome by David Hungerford and Peter Nowell, the discovery that the abnormality arises from a chromosomal translocation, by Janet Rowley, and the cloning of the 9;22 translocation breakpoints by Nora Heisterkamp, John Groffen, and colleagues.
authors.affiliation: Centre for Human Genetics, Bangalore, India.
authors.forename: H Sharat
authors.initials: HS
authors.lastname: Chandra
authors.forename: Nora C
authors.initials: NC
authors.lastname: Heisterkamp
authors.forename: Alice
authors.initials: A
authors.lastname: Hungerford
authors.forename: Jennifer J D
authors.initials: JJ
authors.lastname: Morrissette
authors.forename: Peter C
authors.initials: PC
authors.lastname: Nowell
authors.forename: Janet D
authors.initials: JD
authors.lastname: Rowley
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Testa
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D003001:Cloning, Molecular; D003582:Cytogenetics / Q000266:history / Q000379:methods / Q000639:trends; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics / Q000266:history*; D010677:Philadelphia Chromosome; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D014178:Translocation, Genetic
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate