title: Comparison of "triggers" using leuprolide acetate alone or in combination with low-dose human chorionic gonadotropin.
abstract: This retrospective study of fresh autologous blastocyst transfers in high responders compared ongoing pregnancy rates in cycles that followed trigger with GnRH agonist (GnRHa) alone with standard luteal support, GnRHa alone with enhanced luteal support, or GnRHa with concomitant low-dose hCG (dual trigger). Ongoing pregnancy rates were significantly increased with the dual trigger or with enhanced luteal support, whereas the incidence of clinically significant ovarian hyperstimulation syndrome was 0.0% in the groups receiving only GnRHa and 0.5% (1 of 182) in patients receiving GnRHa with concomitant low-dose hCG.
authors.affiliation: Fertility Center of Las Vegas, Las Vegas, Nevada 89117, USA. bsshapiro@aol.com
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Shapiro
authors.forename: Said T
authors.initials: ST
authors.lastname: Daneshmand
authors.forename: Forest C
authors.initials: FC
authors.lastname: Garner
authors.forename: Martha
authors.initials: M
authors.lastname: Aguirre
authors.forename: Cynthia
authors.initials: C
authors.lastname: Hudson
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000009:adverse effects; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage* / Q000009:adverse effects; D009505:Nevada; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced / Q000517:prevention & control; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide