title: Total synthesis of (±)-aspidophylline A.
abstract: We report the total synthesis of (±)-aspidophylline A, one of many complex furoindoline-containing alkaloids that has not been synthesized previously. Our route features a number of key transformations, including a Heck cyclization to assemble the [3.3.1]-bicyclic scaffold as well as a late-stage interrupted Fischer indolization to install the furoindoline and construct the natural product's pentacyclic framework.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
authors.forename: Liansuo
authors.initials: L
authors.lastname: Zu
authors.forename: Ben W
authors.initials: BW
authors.lastname: Boal
authors.forename: Neil K
authors.initials: NK
authors.lastname: Garg
mesh_terms: D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D026121:Indole Alkaloids