title: Microencapsulation of bioactive nanoparticles.
abstract: Supported or modified enzymes in the form of mobile nanoparticles are designed for enhanced activities and stabilities; however, their practical operations are dwarfed due to their tiny size which always makes recycling an arduous task and a potential risk to the environment. To overcome such drawbacks, this chapter describes a method for the preparation of a new form of microcapsules, possessing single-cavity compartments and nano-pores in the shell, to encage nanoparticle-based biocatalysts and form cell-like microreactors (CLMRs). The encaged nanoscale catalysts are maintained their high activities as in a bulk-phase solution, while they could be handled as materials of sizes hundreds-fold larger.
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Guanghui
authors.initials: G
authors.lastname: Ma
mesh_terms: D055162:Biocatalysis; D019149:Bioreactors; D002918:Chymotrypsin / Q000737:chemistry / Q000378:metabolism*; D004339:Drug Compounding / Q000379:methods*; D004655:Emulsions / Q000737:chemistry; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism*; D005022:Ethyldimethylaminopropyl Carbodiimide / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry* / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D058105:Polymerization; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D004655:Emulsions; D004800:Enzymes, Immobilized; D008689:Methacrylates; D013501:Surface-Active Agents; C008384:methacrylic acid; D002918:Chymotrypsin; C117608:alpha-chymotrypsin; D005022:Ethyldimethylaminopropyl Carbodiimide