title: Novel biodegradable α-TCP/poly(amino acid) composite artificial lamina following spinal surgery for prevention of intraspinal scar adhesion.
abstract: Biodegradable copolymer α-TCP/poly(amino acid) composite artificial lamina was prepared and used in goat cervical vertebra resection repair. Cervical 4 was removed by laminectomy, and a vertebra defect of 27 × 9 mm was made. α-TCP/poly(amino acid) composite artificial lamina was inserted in the test group. The efficiency of the copolymer during repair and reconstruction of the goats' vertebra was tested by using X-ray, CT scanning, and histological and biomechanical measurements. In the 24 weeks following the operation, the artificial lamina refrained from shifting, and no dural adhesion pressure was observed. In contrast, the control group suffered from infiltration of soft tissue in the spinal canal, dural pressure and α-TCP/poly(amino acid) degradation. In conclusion, α-TCP/poly(amino acid) composite artificial lamina can significantly prevent scar tissue from infiltrating the spinal canal.
authors.affiliation: Department of Orthopaedic Surgery, The Huaxi Hospital, Si-Chuan University, 37 Waiguoxuexiang, Sichuan 610041, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Ran
authors.forename: Yue-Ming
authors.initials: YM
authors.lastname: Song
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Liu
authors.forename: Quan
authors.initials: Q
authors.lastname: Gong
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Jian-Cheng
authors.initials: JC
authors.lastname: Zeng
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Yuan
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D002574:Cervical Vertebrae / Q000601:surgery*; D002921:Cicatrix / Q000517:prevention & control*; D006041:Goats; D011108:Polymers; D013122:Spinal Diseases / Q000517:prevention & control*; D000267:Tissue Adhesions / Q000517:prevention & control; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011108:Polymers