title: Oplopanphesides A-C, three new phenolic glycosides from the root barks of Oplopanax horridus.
abstract: Three new phenolic glycosides, named oplopanphesides A-C (1-3), have been isolated from the root barks of Oplopanax horridus. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques. These phenolic glycosides possess a novel feature in their sugar moieties that a 3-hydroxy-3-methylglutaryl moiety was connected with C-6 of the β-D-glucopyranosyl group. Those compounds showed no cytotoxic effects against human cancer cell lines (MDA-231 and MCF-7) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method.
authors.affiliation: Institute of Chinese Medical Sciences, University of Macau, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Huang
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Zhang
authors.forename: Lan-Zhen
authors.initials: LZ
authors.lastname: Meng
authors.forename: Chun-Su
authors.initials: CS
authors.lastname: Yuan
authors.forename: Chong-Zhi
authors.initials: CZ
authors.lastname: Wang
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D005260:Female; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D028002:Oplopanax / Q000737:chemistry* / Q000378:metabolism; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry* / Q000378:metabolism; D014407:Tumor Cells, Cultured; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D010636:Phenols; C560280:oplopanpheside A; C560281:oplopanpheside B; C560282:oplopanpheside C; D000520:alpha-Glucosidases