title: Dramatic changes in catestatin are associated with hemodynamics in acute myocardial infarction.
abstract: Acute myocardial infarction (AMI) is characterized by complex neuroendocrine activation. To investigate catestatin profiles, serial catestatin levels were determined by enzyme-linked immunosorbent assay in the first week after AMI in 50 patients. Catestatin levels reduced at admission and negatively correlated with heart rates; it increased significantly on the third day but remained decreased at 1 week and positively with blood pressure. In a subgroup of 20 patients admitted within 4 h after onset, circulating catestatin correlated inversely with norepinephrine. Catestatin might be involved in the course of AMI and act as a tool in monitoring the progression of AMI.
authors.affiliation: Department of Cardiology, Peking University Third Hospital, Beijing, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Wang
authors.forename: Shunlin
authors.initials: S
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.forename: Dan
authors.initials: D
authors.lastname: Zhu
authors.forename: Lin
authors.initials: L
authors.lastname: Mi
authors.forename: Guisong
authors.initials: G
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D053379:Chromogranin A / Q000097:blood*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D009490:Neurosecretory Systems / Q000737:chemistry; D009638:Norepinephrine; D019370:Observation; D010446:Peptide Fragments / Q000097:blood*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D053379:Chromogranin A; D010446:Peptide Fragments; C109084:chromogranin A (344-364); D009638:Norepinephrine