title: The role of carnitine in preventing renal damage developed as a result of infrarenal aortic ischemia-reperfusion.
abstract: BACKGROUND
  This study was designed to use carnitine for preventing deposition of end products of lipid peroxidation in rat models in the prevention of ischemia-reperfusion (IR) damage frequently seen following operations of infrarenal abdominal aorta (AA).
  
  
  METHODS
  Forty male rats of Sprague-Dawley type were evenly (n = 8) randomized to five groups: sham laparotomy (SHAM), carnitine control (CC), aortic IR (AIR), AIR + low-dose carnitine (AIR+LDC), and AIR + high-dose carnitine (AIR+HDC).
  
  
  RESULTS
  Compared to other groups, serum creatinine levels of AIR group were significantly higher. Also tissue malondialdehyde (MDA) levels of AIR group were significantly higher compared to SHAM, CC, and AIR+HDC groups. In histopathological examination, although tubular necrosis atrophy and tubular degeneration observed in AIR group showed regression with low-dose carnitine, tubular necrosis atrophy, tubular degeneration, glomerular damage, and vascular congestion thrombosis decreased with high-dose carnitine. Total score of histological damage was significantly higher in AIR, AIR+LDC, and AIR+HDC groups compared to SHAM and CC groups. Moreover, total score of histological damage was significantly lower in AIR+HDC group than AIR+LDC group.
  
  
  CONCLUSIONS
  In this study, we showed carnitine can partially prevent renal damage in infrarenal AIR models of rats. This result may open new prospects to us in the prevention of renal IR damage during surgery of aorta.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. serefyuksel@aku.edu.tr
authors.forename: Seref
authors.initials: S
authors.lastname: Yuksel
authors.forename: Mehmet Tugrul
authors.initials: MT
authors.lastname: Sezer
authors.forename: Onder
authors.initials: O
authors.lastname: Sahin
authors.forename: Recep
authors.initials: R
authors.lastname: Sutcu
authors.forename: Cevdet
authors.initials: C
authors.lastname: Koçogullari
authors.forename: Haci Ramazan
authors.initials: HR
authors.lastname: Yilmaz
authors.forename: Efkan
authors.initials: E
authors.lastname: Uz
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Kara
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Aydin
authors.forename: Atilla
authors.initials: A
authors.lastname: Altuntas
mesh_terms: D058186:Acute Kidney Injury / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery*; D002331:Carnitine / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D014803:Vitamin B Complex; D002331:Carnitine