title: CD4(+)CD25(high)CD127(low) regulatory T cells in patients with stable angina and their dynamics after intracoronary sirolimus-eluting stent implantation.
abstract: Rapamycin contributes to the expansion of regulatory T cells (Tregs) in vitro. We investigated CD4(+)CD25(high)CD127(low) Treg level dynamics as well as the major parameters of cell immunity and sCD25 and highly sensitive C-reactive protein (hsCRP) concentrations in the blood of patients after coronary stenting (CS) with sirolimus (rapamycin)-eluting stents (SES; n = 43). The relation between initial Treg values and the severity of coronary atherosclerosis was observed. Treg and sCD25 levels were increased 1 month after CS versus baseline values and versus data in the control group (coronary angiography [CA], n = 20). A positive correlation between Treg and sCD25 levels was reported, whereas no relation was observed with the length of SES implanted. HsCRP level was increased during the first 7 days and returned to baseline values 1 month after CS/CA. Treg content is lower in patients with multivessel CAD. Elevated levels of Tregs and sCD25 after SES implantation might occur because of the immunomodulating effect of rapamycin.
authors.affiliation: Russian Cardiology Research Center, Third Cherepkovskaya str., 15A, Moscow 121552, Russia. potehina@gmail.com
authors.forename: Alexandra V
authors.initials: AV
authors.lastname: Potekhina
authors.forename: Sergey I
authors.initials: SI
authors.lastname: Provatorov
authors.forename: Vladimir O
authors.initials: VO
authors.lastname: Sokolov
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Pylaeva
authors.forename: Valery P
authors.initials: VP
authors.lastname: Masenko
authors.forename: Elena A
authors.initials: EA
authors.lastname: Noeva
authors.forename: Nadezhda B
authors.initials: NB
authors.lastname: Kukhtina
authors.forename: Tatiana L
authors.initials: TL
authors.lastname: Krasnikova
authors.forename: Tatiana I
authors.initials: TI
authors.lastname: Arefieva
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D017222:Angioplasty, Balloon, Laser-Assisted; D002097:C-Reactive Protein / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D053699:Interleukin-7 Receptor alpha Subunit / Q000276:immunology; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020123:Sirolimus / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
chemical_list: D007155:Immunologic Factors; D053645:Interleukin-2 Receptor alpha Subunit; D053699:Interleukin-7 Receptor alpha Subunit; D002097:C-Reactive Protein; D020123:Sirolimus