title: Lathyrane diterpenoids from the roots of Euphorbia micractina and their biological activities.
abstract: Seventeen new lathyrane diterpenoids (1-17) and two known analogues have been isolated from an ethanolic extract of Euphorbia micractina roots. Their structures including absolute configurations were determined by spectroscopic data interpretation and single-crystal X-ray crystallography. Compound 10 showed activity against HIV-1 replication in vitro, with an IC50 value of 8.2 μM. Compounds 6, 7, 11, 14, 15, and 18, at 10(-6) M, showed significant vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxation rates of 48%, 41%, 42%, 48%, 50%, and 53%, respectively.
authors.affiliation: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, and Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Wendong
authors.initials: W
authors.lastname: Xu
authors.forename: Chenggen
authors.initials: C
authors.lastname: Zhu
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Yanru
authors.initials: Y
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Xiong
authors.forename: Sujuan
authors.initials: S
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.forename: Hua
authors.initials: H
authors.lastname: Sun
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Wang
authors.forename: Jiangong
authors.initials: J
authors.lastname: Shi
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D004224:Diterpenes; C530347:lathyrane