title: p53 is involved in the inhibition of cell proliferation mediated by activin A in cultured human prostate cancer LNCaP cells.
abstract: Activin A in a concentration ranging from 0.7 to 75 ng/ml specifically inhibited cell growth of an androgen-sensitive human prostate cancer line, LNCaP, but had no effects on two androgen-insensitive human prostate cancer lines, PC3 and DU-145. This activin-mediated inhibition of cell growth in LNCaP cells results from a decrease of cell proliferation and an increase of apoptosis. Northern blot analysis of mRNA expression encoding human p53 in untreated and activin-treated LNCaP cells resulted in upregulation of p53 gene expression. We conclude that autocrine inhibition of cell growth in LNCaP cells by activin is in part related to the expression of the p53 gene.
authors.forename: S
authors.initials: S
authors.lastname: Ying
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Batres
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: S
authors.initials: S
authors.lastname: Lin
authors.forename: G
authors.initials: G
authors.lastname: Li