title: Expressions of protein oxidation markers, dityrosine and advanced oxidation protein products in acetaminophen-induced liver injury in rats.
abstract: The purpose of this study was to evaluate whether dityrosine and advanced oxidation protein products (AOPP) were useful as biomarkers for monitoring the development of acetaminophen-induced liver injury. Dityrosine immunoexpression in the liver along with plasma AOPP concentration was examined up to 24 hr post-acetaminophen injection in rats. The histopathological changes in the liver appeared 3 hr after acetaminophen injection and became exacerbated with time. The immunohistological expression of dityrosine was also first detected in the damaged hepatocytes 3 hr after the injection and became more accentuated at 6, 12 and 24 hr in accompanying with the elevation of plasma AOPP concentration. These results suggested that dityrosine and AOPP expressions might be useful biomarkers for monitoring the development of acetaminophen-induced liver injury.
authors.affiliation: United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sugiyama
authors.forename: Aino
authors.initials: A
authors.lastname: Masuda
authors.forename: Tairin
authors.initials: T
authors.lastname: Ochi
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D018712:Analgesics, Non-Narcotic; D015415:Biomarkers; D011506:Proteins; D000082:Acetaminophen; D014443:Tyrosine; C007543:dityrosine