title: Relationship between expression of plasminogen activator system and metastatic ability in human cancers.
abstract: The gene expressions of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PR), and plasminogen activator inhibitor (PAI)-1 and -2 in human tumor cell lines and human gastric cancer tissues were analyzed using the reverse transcription (RT)-PCR. The expression patterns were compared with experimental metastatic ability in chick embryo or clinicopathological findings. The results indicate that the function of u-PA binding to u-PR and the diminished expression of PAI-2 are significantly involved in the process of cancer metastasis and PAI-2 may be more effective in regulating u-PA activity than PAI-1.
authors.affiliation: KANAZAWA UNIV,CANC RES INST,DEPT EXPTL THERAPEUT,SCH MED,KANAZAWA,ISHIKAWA 920,JAPAN. KANAZAWA UNIV,SCH MED,DEPT SURG 2,KANAZAWA,ISHIKAWA 920,JAPAN.
authors.forename: M
authors.initials: M
authors.lastname: Noguchitakino
authors.forename: Y
authors.initials: Y
authors.lastname: Endo
authors.forename: Y
authors.initials: Y
authors.lastname: Yonemura
authors.forename: T
authors.initials: T
authors.lastname: Sasaki