title: Therapeutic effect of co-transplantation of neuregulin-1-transfected Schwann cells and bone marrow stromal cells on spinal cord hemisection syndrome.
abstract: The aim of this present study is to evaluate the therapeutic effect of co-transplantation of neuregulin-1-transfected Schwann cells (SCs) and bone marrow stromal cells (BMSCs) on a rat model of spinal cord hemi-section injuries (Brown-Séquard syndrome), which is relevant to human clinical spinal cord injury. Both in vivo and in vitro data we received demonstrated that co-transplantation BMSCs with NRG1-transfected SCs reduced the size of cystic cavities, promoted axonal regeneration and hind limb functional recovery in comparison with SCs or BMSCs transplantation alone or together, and this treatment could provide important insights into potential therapies of spinal cord hemi-section injuries.
authors.affiliation: Department of Histoembryology, Mu Dan Jiang Medical College, Mu Dan Jiang 157011, China. zhangjifei777@yahoo.com.cn
authors.forename: Ji Fei
authors.initials: JF
authors.lastname: Zhang
authors.forename: Fu Sheng
authors.initials: FS
authors.lastname: Zhao
authors.forename: Geng
authors.initials: G
authors.lastname: Wu
authors.forename: Qing Fei
authors.initials: QF
authors.lastname: Kong
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.forename: Jingyan
authors.initials: J
authors.lastname: Cao
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jing Hua
authors.initials: JH
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xu Dong
authors.initials: XD
authors.lastname: Jin
authors.forename: Hu Lun
authors.initials: HL
authors.lastname: Li
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D016026:Bone Marrow Transplantation / Q000379:methods*; D003560:Cysts / Q000473:pathology / Q000628:therapy; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D020890:Neuregulin-1 / Q000235:genetics* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012583:Schwann Cells / Q000502:physiology / Q000637:transplantation*; D013119:Spinal Cord Injuries / Q000473:pathology / Q000628:therapy*; D017154:Stromal Cells / Q000502:physiology / Q000637:transplantation; D013577:Syndrome; D014162:Transfection / Q000379:methods
chemical_list: D020890:Neuregulin-1; C490580:Nrg1 protein, rat