title: The impact of non- and genetically modified soybean diets in aorta wall remodeling.
abstract: The aim of this study was to evaluate the influence of nongenetically modified soybean (non-GMS) and genetically modified soybean (GMS) meal on growth and cardiometabolic parameters in rats. Thirty male Wistar rats were divided into 3 groups (n= 10): non-GMS, GMS, and control group (CG). All animals received water and an isocaloric diet ad libitum for 455 d. Blood was drawn by cardiac puncture, and serum was separated for subsequent biochemical analyses (total cholesterol, triacylglycerols, insulin, glucose, and testosterone). The aorta was quickly harvested and fixed; the body fat mass was removed and weighed. Non-GMS and GMS had a growth index (GI) similar to CG but with a lower body weight (P < 0.05) and a lower amount of body fat mass (P < 0.05). Total cholesterol, triacylglycerol, glucose concentrations, and aortic tunics were reduced (P < 0.05) in non-GMS and GMS compared to CG. Non-GMS and GMS are able to reduced serum cholesterol, triacylglycerols, glucose, and aortic remodeling in aged rats. No differences were observed between non-GMS and GMS in all parameters.
authors.affiliation: Dept. of Nutrition and Dietetics, Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense Univ., 24020-140, 30/5th floor, Rio de Janeiro, Brazil. juliobd@gmail.com
authors.forename: Julio B
authors.initials: JB
authors.lastname: Daleprane
authors.forename: Mauricío A
authors.initials: MA
authors.lastname: Chagas
authors.forename: Guillermo C
authors.initials: GC
authors.lastname: Vellarde
authors.forename: Cristiane F
authors.initials: CF
authors.lastname: Ramos
authors.forename: Gilson T
authors.initials: GT
authors.lastname: Boaventura
mesh_terms: D050154:Adiposity; D000375:Aging; D000818:Animals; D001011:Aorta / Q000473:pathology*; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D004032:Diet; D030841:Food, Genetically Modified / Q000009:adverse effects*; D008297:Male; D030821:Plants, Genetically Modified; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D045730:Soy Foods; D013025:Glycine max / Q000009:adverse effects / Q000235:genetics; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol