title: [Bone quality in lifestyle-related diseases].
abstract: Lifestyle-related diseases deteriorate bone quality in terms of material properties. Collagen cross-link formation is thought to be a determinant of material strength. Hyperglycemia, oxidative stress, carbonyl stress, and hyperhomocysteinemia induce the reduction in beneficial enzymatic cross-links and the accumulation of disadvantageous non-enzymatic cross-link, Advanced glycation end products (AGEs, Pentosidine) in bone. In this review, we describe that lifestyle-related diseases are crucial determinants of detrimental crosslinking of bone collagen that have been reported in the literature.
authors.affiliation: Department of Orthopaedic Surgery, Jikei University School of Medicine.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Saito
authors.forename: Keishi
authors.initials: K
authors.lastname: Marumo
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives / Q000652:urine; D001842:Bone and Bones / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D050723:Fractures, Bone / Q000209:etiology; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia; D020138:Hyperhomocysteinemia; D008019:Life Style; D008239:Lysine / Q000031:analogs & derivatives / Q000652:urine; D018384:Oxidative Stress; D012306:Risk; D026681:Vitamin B 6 Deficiency
chemical_list: D017127:Glycation End Products, Advanced; D003094:Collagen; D001120:Arginine; C062187:pentosidine; D008239:Lysine