title: The elevated homocysteine stimulates changes of haemostatic function of plasma isolated from breast cancer patients.
abstract: The aim of our study was to explain the effect of elevated homocysteine (measured by HPLC) on haemostatic activity of plasma from breast cancer patients (fibrin polymerization and lysis; the thrombin and prothrombin time), because homocysteine (Hcys) induces changes in haemostasis, as well blood clotting as fibrinolysis. Patients were hospitalized in Department of Oncological Surgery, Medical University of Lodz, Poland. All patients have not had preadjuvant therapy, and samples from patients were taken before surgery. We observed that changes of selected parameters of haemostatic properties of plasma, e.g., the prothrombin time and thrombin time were prolonged in plasma from invasive breast cancer when compared with the control group (healthy subjects) and patients with benign breast diseases. Our results showed also that the correlation between the increased amount of Hcys and changes of selected parameters of haemostasis in invasive breast cancer patients exists. Considering the data presented in this study, we suggest that the elevated Hcys in invasive breast cancer patients may induce the changes of haemostatic properties of plasma isolated from these patients.
authors.affiliation: Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kedzierska
authors.forename: Joanna
authors.initials: J
authors.lastname: Malinowska
authors.forename: Rafal
authors.initials: R
authors.lastname: Glowacki
authors.forename: Beata
authors.initials: B
authors.lastname: Olas
authors.forename: Edward
authors.initials: E
authors.lastname: Bald
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Jeziorski
authors.forename: Janusz
authors.initials: J
authors.lastname: Piekarski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000097:blood*; D018270:Carcinoma, Ductal, Breast / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis; D006487:Hemostasis; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013918:Thrombin Time
chemical_list: D006710:Homocysteine; D005337:Fibrin