title: Plantago major protective effects on antioxidant status after administration of 7,12-Dimethylbenz(a)anthracene in rats.
abstract: OBJECTIVE
  The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA).
  
  
  METHODS
  Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days.
  
  
  RESULTS
  Significant decrease in catalase (P < 0.05), carbonic anhydrase (p ≤ 0.01), reduced glutathione (GSH) (P < 0.01) and total protein (P < 0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups.
  
  
  CONCLUSIONS
  The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.
authors.affiliation: Department of Pharmacology, Faculty of Medical, Yuzuncu Yil University, Van, Turkey. okhanoto@hotmail.com
authors.forename: Gokhan
authors.initials: G
authors.lastname: Oto
authors.forename: Suat
authors.initials: S
authors.lastname: Ekin
authors.forename: Hulya
authors.initials: H
authors.lastname: Ozdemir
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
authors.forename: Semih
authors.initials: S
authors.lastname: Yasar
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Levent
authors.forename: Ismet
authors.initials: I
authors.lastname: Berber
authors.forename: Baris
authors.initials: B
authors.lastname: Kaki
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002256:Carbonic Anhydrases / Q000378:metabolism; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000627:therapeutic use*; D010943:Plantago / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D002273:Carcinogens; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene; D002374:Catalase; D002256:Carbonic Anhydrases; D005978:Glutathione