title: Mechanism of K+/Na+ selectivity in potassium channels from the perspective of the non-selective bacterial channel NaK.
abstract: Studies of the non-selective NaK channel as a model system provided detailed structural and functional insights into different factors that modulate selective ion conductance. The combination of structural and functional studies of WT- and mutant forms of NaK channel show that apparent conservation of the multiple binding sites in the canonical selectivity filter of K-channel is essential component of the observed robust Na (+) discrimination.
authors.affiliation: Department of Biological Sciences, University of Calgary, Institute for Biocomplexity and Informatics, Calgary, AB, Canada.
authors.forename: Serdar
authors.initials: S
authors.lastname: Durdagi
authors.forename: Sergei Y
authors.initials: SY
authors.lastname: Noskov
mesh_terms: D000818:Animals; D006801:Humans; D015640:Ion Channel Gating; D007477:Ions / Q000737:chemistry*
chemical_list: D007477:Ions