title: [Adipocytes and bone metabolism].
abstract: Adipocytes, osteoblasts and chondrocytes derive from common mesenchymal stem cells. A number of factors were reported to regulate differentiation of multiple cell types among adipocytes, osteoblasts and chondrocytes. Thiazolidinediones are prescribed to treat diabetes in obese subjects, but recent clinical data suggested that it increases a risk of bone fracture especially in postmenopausal women. Here, we will review recent advances in the researches of mutual connection between adipocytes and bone metabolism.
authors.affiliation: Department of Diabetes and Metabolic Diseases, the University of Tokyo.
authors.forename: Hironori
authors.initials: H
authors.lastname: Waki
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
mesh_terms: D017667:Adipocytes / Q000502:physiology*; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D050171:Dyslipidemias / Q000378:metabolism*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism; D026502:LDL-Receptor Related Proteins / Q000502:physiology; D008077:Lipoproteins, LDL / Q000502:physiology; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D012306:Risk; D016103:Spinal Fractures / Q000517:prevention & control; D014280:Triglycerides / Q000097:blood; D051153:Wnt Proteins / Q000502:physiology
chemical_list: D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; C555475:LRP6 protein, human; D008077:Lipoproteins, LDL; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D014280:Triglycerides; D051153:Wnt Proteins; C099252:oxidized low density lipoprotein