title: Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease.
abstract: OBJECTIVE
  To assess serum brain derived neurotrophic factor (BDNF) concentrations as a correlate of cardiopulmonary fitness and as a predictor of cognitive performance in subjects with coronary artery disease (CAD).
  
  
  METHODS
  Serum BDNF concentrations were assayed by ELISA and fitness was assessed using a standardized exercise stress test. The Mini Mental Status Examination (MMSE), California Verbal Learning Test 2nd Ed., Stroop, Trail Making Test B and the Digit Symbol-Coding task were administered. The val66met BDNF genotype and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations were determined as potential confounders.
  
  
  RESULTS
  In subjects with CAD (n=88; 85.2% male, mean age 62.8±10.5 yr), cardiopulmonary fitness was associated with higher serum BDNF concentrations (β=.305, p=.013). Higher serum BDNF concentrations were associated with higher MMSE scores (F(1,87)=15.406, p<.0005) and better performance on the Digit Symbol-Coding task (F(1,87)=9.620, p=.003). IL-6, TNF-α and the val66met genotype did not influence these results.
  
  
  CONCLUSIONS
  Serum BDNF concentrations were associated with cardiopulmonary fitness, psychomotor processing speed and overall cognition in subjects with CAD.
authors.affiliation: Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
authors.forename: W
authors.initials: W
authors.lastname: Swardfager
authors.forename: N
authors.initials: N
authors.lastname: Herrmann
authors.forename: S
authors.initials: S
authors.lastname: Marzolini
authors.forename: M
authors.initials: M
authors.lastname: Saleem
authors.forename: P
authors.initials: P
authors.lastname: Shammi
authors.forename: P I
authors.initials: PI
authors.lastname: Oh
authors.forename: P R
authors.initials: PR
authors.lastname: Albert
authors.forename: M
authors.initials: M
authors.lastname: Daigle
authors.forename: A
authors.initials: A
authors.lastname: Kiss
authors.forename: K L
authors.initials: KL
authors.lastname: Lanctôt
mesh_terms: D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000235:genetics; D002097:C-Reactive Protein / Q000032:analysis; D003071:Cognition / Q000502:physiology*; D015986:Confounding Factors, Epidemiologic; D003327:Coronary Disease / Q000097:blood* / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation / Q000628:therapy; D004797:Enzyme-Linked Immunosorbent Assay; D005080:Exercise Test; D005260:Female; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010809:Physical Fitness / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide; D011597:Psychomotor Performance; D012307:Risk Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein