title: New experiments for an undivided genetics.
abstract: There used to be a broad split within the experimental genetics research community between those who did mechanistic research using homozygous laboratory strains and those who studied patterns of genetic variation in wild populations. The former benefited from the advantage of reproducible experiments, but faced difficulties of interpretation given possible genomic and evolutionary complexities. The latter research approach featured readily interpreted evolutionary and genomic contexts, particularly phylogeny, but was poor at determining functional significance. Such burgeoning experimental strategies as genome-wide analysis of quantitative trait loci, genotype-phenotype associations, and the products of experimental evolution are now fostering a unification of experimental genetic research that strengthens its scientific power.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697-2525, USA. mrrose@uci.edu
authors.forename: Michael R
authors.initials: MR
authors.lastname: Rose
authors.forename: Laurence D
authors.initials: LD
authors.lastname: Mueller
authors.forename: Molly K
authors.initials: MK
authors.lastname: Burke
mesh_terms: D000818:Animals; D019020:Directed Molecular Evolution; D005821:Genetic Techniques; D005828:Genetics, Population; D016678:Genome / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D040641:Quantitative Trait Loci / Q000235:genetics