title: Effects of unintentional exposure of children to compounded transdermal sex hormone therapy.
abstract: Gynecomastia and rapid growth progressed in twin brothers and pubic hair in one, over a period of 2 years. A combination of contra- and isosexual development was induced by transdermal exposure to compounded estradiol, estrone, and testosterone creams applied to their mother's body as part of a hormone replacement regimen.
authors.affiliation: Pediatric Endocrinology of San Diego, University of California San Diego, San Diego, CA 92123, USA.
authors.forename: Sherry L
authors.initials: SL
authors.lastname: Franklin
mesh_terms: D000279:Administration, Cutaneous; D000365:Age Determination by Skeleton; D002675:Child, Preschool; D004339:Drug Compounding; D004958:Estradiol / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood; D004970:Estrone / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D006177:Gynecomastia / Q000139:chemically induced*; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D006801:Humans; D008297:Male; D008593:Menopause; D011629:Puberty, Precocious / Q000139:chemically induced*; D013739:Testosterone / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D012739:Gonadal Steroid Hormones; D004970:Estrone; D013739:Testosterone; D004958:Estradiol