title: Diagnostic features of mild cellulitis phlegmon in patients with rheumatoid arthritis treated with tocilizumab: a report of two cases.
abstract: Two cases of subcutaneous soft tissue infection in 30 RA patients treated with tocilizumab are reported. In both patients, local redness, swelling, and heat were observed around the affected site. WBC spikes and such local findings were suggested to be clinically useful for the early detection of low-grade subcutaneous infection in RA patients whose disease is tightly controlled with tocilizumab. Of note, the C-reactive protein (CRP) level and temperature lacked clinical utility for such detection.
authors.affiliation: Department of Orthopaedics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirao
authors.forename: Akihide
authors.initials: A
authors.lastname: Nampei
authors.forename: Kenrin
authors.initials: K
authors.lastname: Shi
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Norihiro
authors.initials: N
authors.lastname: Nishimoto
authors.forename: Jun
authors.initials: J
authors.lastname: Hashimoto
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects* / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002481:Cellulitis / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D002097:C-Reactive Protein; C502936:tocilizumab