title: Visceral pain: spinal afferents, enteric mast cells, enteric nervous system and stress.
abstract: This review aims to examine current basic and clinical concepts, the results of which are expanding our understanding of visceral hypersensitivity and functional abdominal pain of intestinal origin in relation to the enteric nervous system (ENS), spinal sensory neurons and enteric mast cells. Advances in this sphere are translating to improved insight into chronic functional abdominal and pelvic pain syndromes in general.
authors.affiliation: Department of Physiology & Cell Biology, The Ohio State University College of Medicine Columbus, Ohio 43210, USA. wood.13@osu.edu
authors.forename: Jackie D
authors.initials: JD
authors.lastname: Wood
mesh_terms: D015746:Abdominal Pain / Q000503:physiopathology*; D000344:Afferent Pathways; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D017615:Enteric Nervous System / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000503:physiopathology*; D008407:Mast Cells / Q000473:pathology*; D013116:Spinal Cord / Q000503:physiopathology*; D013312:Stress, Physiological
chemical_list: D003346:Corticotropin-Releasing Hormone