title: HLA class I and advanced melanoma in Israeli Jews.
abstract: KLA class I antigen was studied in Jewish melanoma patients. The frequency of HLA A24, A26 and B38 was significantly higher in the melanoma patients (34.7%, 39.1% and 38.6%, respectively) compared to controls (16.6%, 18.5% and 20.6%, respectively) (p<0.005). HLA A24 antigen was significantly higher in the metastatic patients (44.8%) compared to the non-metastatic (11.1%) (p<0.001). The frequency of this antigen was also higher in the patients with recurrent disease (16.6%) than in the high risk patients with no recurrence (11.1%). HLA class I and A24 may play a role in the biologic behavior of malignant melanoma.
authors.affiliation: RABIN MED CTR,TISSUE TYPING LAB,IL-49100 PETAH TIQWA,ISRAEL. RABIN MED CTR,ONCOL UNIT,IL-49100 PETAH TIQWA,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL.
authors.forename: J
authors.initials: J
authors.lastname: Schachter
authors.forename: T
authors.initials: T
authors.lastname: Klein
authors.forename: B
authors.initials: B
authors.lastname: Klein
authors.forename: A
authors.initials: A
authors.lastname: Adler