title: Relationship between white blood cell count and in-hospital outcomes in acute coronary syndrome patients from the Middle East.
abstract: We evaluated the relationship between admission white blood cell (WBC) count and in-hospital outcomes in acute coronary syndrome (ACS) patients from the Middle East. Data were analyzed from 7806 consecutive patients with ACS who were divided into 4 groups (G) according to their WBC count (× 10(9)/L; G1: < 6.00; G2: 6.00-9.99; G3: 10.00-11.99; G4: ≥ 12.00). After significant covariate adjustment, those in G4 were 68% more likely to have cardiogenic shock than those in G1 (95% confidence interval [CI]: 1.05-2.68; P = .030) and G2 (odds ratio [OR], 2.02; 95% CI: 1.51-2.71; P < .001). Those in G4 were 2.02 times (95% CI: 1.11-3.67; P = .021) and 65% (95% CI: 1.17-2.32; P = .004) more likely to die in hospital than those in G1 and G2, respectively. Admission WBC count is an independent risk factor for in-hospital cardiogenic shock and mortality, in Middle Eastern patients with ACS. Novel therapeutic agents targeting WBCs in patients with ACS may improve outcomes.
authors.affiliation: Department of Cardiology, Royal Hospital, Muscat, Oman. kjsulaiman@hotmail.com
authors.forename: Kadhim
authors.initials: K
authors.lastname: Sulaiman
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Al-Zakwani
authors.forename: Prashanth
authors.initials: P
authors.lastname: Panduranga
authors.forename: Jassim
authors.initials: J
authors.lastname: Al-Suwaidi
authors.forename: Alawi A
authors.initials: AA
authors.lastname: Alsheikh-Ali
authors.forename: Wael
authors.initials: W
authors.lastname: Al Mahmeed
authors.forename: Haitham
authors.initials: H
authors.lastname: Amin
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al-Mutarreb
authors.forename: Khalid
authors.initials: K
authors.lastname: AlHabib
authors.forename: Jawad
authors.initials: J
authors.lastname: Al-Lawati
authors.forename: Mohammed
authors.initials: M
authors.lastname: Zubaid
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000208:ethnology* / Q000401:mortality; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D008877:Middle East; D012307:Risk Factors; D012770:Shock, Cardiogenic / Q000097:blood / Q000453:epidemiology