title: Plasmodium knowlesi malaria in children.
abstract: Plasmodium knowlesi can cause severe malaria in adults; however, descriptions of clinical disease in children are lacking. We reviewed case records of children (age <15 years) with a malaria diagnosis at Kudat District Hospital, serving a largely deforested area of Sabah, Malaysia, during January-November 2009. Sixteen children with PCR-confirmed P. knowlesi monoinfection were compared with 14 children with P. falciparum monoinfection diagnosed by microscopy or PCR. Four children with knowlesi malaria had a hemoglobin level at admission of <10.0 g/dL (minimum lowest level 6.4 g/dL). Minimum level platelet counts were lower in knowlesi than in falciparum malaria (median 76,500/μL vs. 156,000/mL; p = 0.01). Most (81%) children with P. knowlesi malaria received chloroquine and primaquine; median parasite clearance time was 2 days (range 1-5 days). P. knowlesi is the most common cause of childhood malaria in Kudat. Although infection is generally uncomplicated, anemia is common and thrombocytopenia universal. Transmission dynamics in this region require additional investigation.
authors.affiliation: Menzies School of Health Research, Darwin, Northern Territory, Australia. bridget.barber@menzies.edu.au
authors.forename: Bridget E
authors.initials: BE
authors.lastname: Barber
authors.forename: Timothy
authors.initials: T
authors.lastname: William
authors.forename: Mohammad
authors.initials: M
authors.lastname: Jikal
authors.forename: Jenarun
authors.initials: J
authors.lastname: Jilip
authors.forename: Prabakaran
authors.initials: P
authors.lastname: Dhararaj
authors.forename: Jayaram
authors.initials: J
authors.lastname: Menon
authors.forename: Tsin W
authors.initials: TW
authors.lastname: Yeo
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Anstey
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000740:Anemia / Q000209:etiology; D000962:Antimalarials / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008288:Malaria / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology* / Q000635:transmission; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D016790:Plasmodium knowlesi / Q000502:physiology*; D011319:Primaquine / Q000627:therapeutic use; D012189:Retrospective Studies; D012737:Sex Factors; D013921:Thrombocytopenia / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine