title: Electrospray as a tool for drug micro- and nanoparticle patterning.
abstract: Carbamazepine (CBZ) microparticles of different sizes and shapes, including spheres, q-tips, elongated spheres, and tear-shaped particles, were formed by electrospraying solutions of different CBZ concentrations. The particle characteristics were determined by the interplay between jet formation, droplet breakup, solvent evaporation, and eventual particle solidification. The average particle size increased with increasing CBZ concentration, with particles of different shapes being observed for different CBZ concentrations. The cascade of sizes and shapes observed was interpreted in terms of Rayleigh instability theory as applied to charged jets and droplets, with the final sizes depending upon the time needed to evaporate the solvent sufficiently for CBZ to solidify; the lower the initial concentration of CBZ, the smaller the final droplets/particles that are formed.
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
authors.forename: Elke
authors.initials: E
authors.lastname: Scholten
authors.forename: Himanshu
authors.initials: H
authors.lastname: Dhamankar
authors.forename: Lev
authors.initials: L
authors.lastname: Bromberg
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Rutledge
authors.forename: T Alan
authors.initials: TA
authors.lastname: Hatton
mesh_terms: D002220:Carbamazepine / Q000737:chemistry*; D055616:Microtechnology / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D044367:Phase Transition; D013997:Time Factors
chemical_list: D002220:Carbamazepine