title: Lack of microsatellite instability in human prostate-cancer.
abstract: DNA replication errors are especially frequent in repetitive DNA sequences, including microsatellites. Thus, microsatellites are sensitive indicators of the genetic instability observed in many types of human cancers, particularly colorectal cancer. We tested prostate carcinomas for the presence of microsatellite alleles not present in normal tissue from the same individuals. Analysis of 7 microsatellites in each of 30 patients revealed instability at only one microsatellite in one tumor. This level of microsatellite instability, considerably lower than that reported previously, may reflect differences in patient pools. We discuss the implications of the genetic stability of prostate cancers relative to other cancers.
authors.affiliation: UNIV WASHINGTON,SCH MED,DEPT PATHOL,JOSEPH GOTTSTEIN MEM CANC RES LAB,SEATTLE,WA 98195.
authors.forename: F
authors.initials: F
authors.lastname: Christians
authors.forename: D
authors.initials: D
authors.lastname: Connolly
authors.forename: K
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: L
authors.initials: L
authors.lastname: True
authors.forename: L
authors.initials: L
authors.lastname: Loeb