title: EMMPRIN levels in serum of patients with amyotrophic lateral sclerosis.
abstract: OBJECTIVE
  There are evidence that extracellular matrix metalloproteinases (MMPs) may be implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). The extracellular matrix metalloproteinase inducer (EMMPRIN) is said to increase the production of MMPs in cells. The aim of the study was to investigate serum EMMPRIN levels in patients with ALS.
  
  
  METHODS
  The study included 50 patients with ALS and 50 patients from the control group. Serum EMMPRIN levels were measured using the enzyme-linked immunosorbent method.
  
  
  RESULTS
  The study showed that EMMPRIN levels are significantly increased in the serum of the whole group of patients with ALS when compared to the control group and are significantly increased in patients with ALS with severe clinical state compared to patients with mild clinical state (P < 0.05). There was a significant correlation of serum EMMPRIN levels with severity of clinical state of patients with ALS (P < 0.05).
  
  
  CONCLUSIONS
  The results indicate that EMMPRIN is implicated in pathophysiology of ALS and may be the marker of clinical state severity.
authors.affiliation: Department of Neurological Rehabilitation, Medical University in Lublin, Poland. ilzecka@onet.pl
authors.forename: J
authors.initials: J
authors.lastname: Iłżecka
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D051926:Basigin / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: C497886:BSG protein, human; D015415:Biomarkers; D051926:Basigin