title: Therapeutic effectiveness of botulinum toxin type A based on severity of palmar hyperhidrosis.
abstract: A dose of 60 units (U) of botulinum toxin type A (BT-A) has been confirmed to have efficacy for patients with palmoplantar hyperhidrosis. However, the effectiveness of this dose is limited in severe cases defined as sweat production of 2 mg/cm(2) per min or more (measured by the ventilated capsule method) and a Hyperhidrosis Disease Severity Scale (HDSS) grade of 3 or 4. An increased dose of 90 U of BT-A was found to reduce sweating for approximately 7 months. In a comparison of patients with sweat production of more than 2.5 mg/cm(2) per min and an HDSS grade of 4 and patients with sweat production of 2.5 mg/cm(2) per min or less and an HDSS grade of 3, there was no difference in the reduction of sweat production at 5 months, but the duration of the reduced sweating was shorter for the former group. This suggests that there are limits to the efficacy of BT-A for severe forms of the disease with sweat production of more than 2.5 mg/cm(2) per mL.
authors.affiliation: Department of Dermatology, Aichi Medical University School of Medicine, Aichi, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Ito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yanagishita
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ohshima
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tamada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy* / Q000503:physiopathology; D007271:Injections, Intradermal; D008297:Male; D012720:Severity of Illness Index; D013546:Sweating / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A