title: Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice.
abstract: Respiratory viral infections result in severe pulmonary injury, to which host immune response may be a significant contributor. At present, it is not entirely clear the extent to which lung injury is a necessary consequence of host defense. In this report, we use functional genomics approach to characterize the key roles of cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in resistant C57BL/6J and susceptible DBA/2J mice. Infected mice manifested an immune-inflammatory response characterized by the pulmonary influx of neutrophils and mononuclear cells. DBA/2J mice mounted a vigorous immune response, with significant up-regulation of cytokine/chemokine genes in two successive waves through the course of infection. Whereas, C57BL/6J mice displayed an efficient immune response with less severe pathology and clusters of immune-inflammatory responsive genes were exclusively up-regulated on day 4 in this strain. Overall, DBA/2J mice exhibited a dysregulated hyper-inflammatory cytokine/chemokine cascades that does not limit viral spread resulting in a predisposition to severe lung pathology. This response is similar to severe human respiratory paramyxovirus infections, which will serve as a model for the elucidation of hyper-immune inflammatory response that result to severe immunopathology in respiratory viral infections.
authors.affiliation: Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan. syila523@hotmail.com
authors.forename: Ayo Yila
authors.initials: AY
authors.lastname: Simon
authors.forename: Nobuya
authors.initials: N
authors.lastname: Sasaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Ichii
authors.forename: Kiichi
authors.initials: K
authors.lastname: Kajino
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kon
authors.forename: Takashi
authors.initials: T
authors.lastname: Agui
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D016000:Cluster Analysis; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D005434:Flow Cytometry; D020869:Gene Expression Profiling; D006651:Histocytochemistry; D054884:Host-Pathogen Interactions / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology; D007249:Inflammation / Q000276:immunology*; D008168:Lung / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010253:Respirovirus Infections / Q000276:immunology*; D029082:Sendai virus