title: [Antimicrobial use and its correlations with the frequency of carbapenem-resistant Pseudomonas aeruginosa strains in a hospital setting].
abstract: One of the major causes leading to increased antibiotic resistance is excess antimicrobial consumption. We have analysed the correlation between antibiotic use and frequency of carbapenem-resistant Pseudomonas aeruginosa (CRPA) strains in the general intensive care unit of a university hospital Antibiotic use was expressed as number DDD (daily defined doses)/100 occupied hospital bed-days (BD). CRPA incidence rates were determined by number of unique isolates reported to 100,000 BD. The average use of antibiotics between January and August 2008 was 174 DDD/100 BD. The first four most frequently prescribed antibiotics were as follows: first and second generation cephalosporins (47 DDD/100 BD), carbapenemns (29 DDD/100 BD), fluoroquinolones (26 DDD/100 BD) and glycopeptids (20 DDD/100 BD). Average monthly incidence rate of CRPA was 546/100,000 BD (319-773/100,000 BD. CI 95%). There was a correlation between CRPA incidence rate and carbapenem plus fluoroquinolone use (Pearson coefficient of correlation r = 0.7, p < 0.05). Our data showed that the evolution of CRPA incidence rates was related to carbapenem and fluoroquinolone use.
authors.affiliation: Disciplina de Microbiologie, UMF Tg. Mureş.
authors.forename: Edit
authors.initials: E
authors.lastname: Székely
authors.forename: Gabriela
authors.initials: G
authors.lastname: Bucur
authors.forename: Levente
authors.initials: L
authors.lastname: Vass
authors.forename: Manuela
authors.initials: M
authors.lastname: Butiurca
authors.forename: Doina
authors.initials: D
authors.lastname: Bilca
authors.forename: Annamaria
authors.initials: A
authors.lastname: Foldes
authors.forename: Lilla
authors.initials: L
authors.lastname: Lorinczi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology* / Q000627:therapeutic use; D002511:Cephalosporins / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D004363:Drug Utilization / Q000706:statistics & numerical data; D024841:Fluoroquinolones / Q000494:pharmacology; D006020:Glycopeptides / Q000494:pharmacology; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units / Q000706:statistics & numerical data; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification*; D012383:Romania / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002511:Cephalosporins; D024841:Fluoroquinolones; D006020:Glycopeptides