title: The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin.
abstract: Cisplatin, cis-[Pt(Cl(2)(NH(3))(2)], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.
authors.affiliation: CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Wenbing
authors.initials: W
authors.lastname: Hu
authors.forename: Qun
authors.initials: Q
authors.lastname: Luo
authors.forename: Kui
authors.initials: K
authors.lastname: Wu
authors.forename: Xianchan
authors.initials: X
authors.lastname: Li
authors.forename: Fuyi
authors.initials: F
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ma
authors.forename: Jianping
authors.initials: J
authors.lastname: Wang
authors.forename: Jianan
authors.initials: J
authors.lastname: Liu
authors.forename: Shaoxiang
authors.initials: S
authors.lastname: Xiong
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Sadler
mesh_terms: D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000737:chemistry*; D001665:Binding Sites; D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000737:chemistry*; D006801:Humans; D013058:Mass Spectrometry; D017434:Protein Structure, Tertiary; D012709:Serum Albumin / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D012709:Serum Albumin; D015032:Zinc; D002945:Cisplatin