title: Sensitivity of the aortic dissection detection risk score, a novel guideline-based tool for identification of acute aortic dissection at initial presentation: results from the international registry of acute aortic dissection.
abstract: BACKGROUND
  In 2010, the American Heart Association and American College of Cardiology released guidelines for the diagnosis and management of patients with thoracic aortic disease, which identified high-risk clinical features to assist in the early detection of acute aortic dissection. The sensitivity of these risk markers has not been validated.
  
  
  RESULTS
  We examined patients enrolled in the International Registry of Acute Aortic Dissection from 1996 to 2009. The number of patients with confirmed acute aortic dissection who presented with 1 or more of 12 proposed clinical risk markers was determined. An aortic dissection detection (ADD) risk score of 0 to 3 was calculated on the basis of the number of risk categories (high-risk predisposing conditions, high-risk pain features, high-risk examination features) in which patients met criteria. The ADD risk score was tested for sensitivity. Of 2538 patients with acute aortic dissection, 2430 (95.7%) were identified by 1 or more of 12 proposed clinical risk markers. With the use of the ADD risk score, 108 patients (4.3%) were identified as low risk (ADD score 0), 927 patients (36.5%) were intermediate risk (ADD score 1), and 1503 patients (59.2%) were high risk (ADD score 2 or 3). Among 108 patients with no clinical risk markers present (ADD score 0), 72 had chest x-rays recorded, of which 35 (48.6%) demonstrated a widened mediastinum.
  
  
  CONCLUSIONS
  The clinical risk markers proposed in the 2010 thoracic aortic disease guidelines and their application as part of the ADD risk score comprise a highly sensitive clinical tool for the detection of acute aortic dissection.
authors.affiliation: University of Michigan, Ann Arbor, MI 48109-5852, USA.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Rogers
authors.forename: Luke K
authors.initials: LK
authors.lastname: Hermann
authors.forename: Anna M
authors.initials: AM
authors.lastname: Booher
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Nienaber
authors.forename: David M
authors.initials: DM
authors.lastname: Williams
authors.forename: Ella A
authors.initials: EA
authors.lastname: Kazerooni
authors.forename: James B
authors.initials: JB
authors.lastname: Froehlich
authors.forename: Patrick T
authors.initials: PT
authors.lastname: O'Gara
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Montgomery
authors.forename: Jeanna V
authors.initials: JV
authors.lastname: Cooper
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Harris
authors.forename: Stuart
authors.initials: S
authors.lastname: Hutchison
authors.forename: Arturo
authors.initials: A
authors.lastname: Evangelista
authors.forename: Eric M
authors.initials: EM
authors.lastname: Isselbacher
authors.forename: Kim A
authors.initials: KA
authors.lastname: Eagle
mesh_terms: D000208:Acute Disease; D000465:Algorithms; D000784:Aortic Dissection / Q000175:diagnosis* / Q000453:epidemiology*; D001014:Aortic Aneurysm / Q000175:diagnosis* / Q000453:epidemiology*; D003935:Diagnostic Techniques, Cardiovascular / Q000592:standards; D042241:Early Diagnosis; D004632:Emergency Medical Services / Q000379:methods / Q000592:standards*; D006801:Humans; D017410:Practice Guidelines as Topic; D012042:Registries / Q000706:statistics & numerical data; D018570:Risk Assessment / Q000379:methods / Q000592:standards; D012307:Risk Factors; D012680:Sensitivity and Specificity