title: Enantioselective intramolecular crossed Rauhut-Currier reactions through cooperative nucleophilic activation and hydrogen-bonding catalysis: scope and mechanistic insight.
abstract: A highly efficient and enantioselective intramolecular crossed Rauhut-Currier (RC) reaction of nitroolefins with tethered enonates has been developed through cooperative nucleophilic activation and a hydrogen-bonding catalytic strategy (≤98% ee and 98% yield). The reaction features simple experimental procedures and is completely chemoselective and atom-economic in character. The potential synthetic applications have been demonstrated by the conversion of the RC reaction products into biologically and pharmaceutically valuable compounds with highly diastereoselectivity. In addition, computational investigations were employed to support the proposed mechanism and to obtain a good understanding of the origin of the stereoselectivity in RC reactions.
authors.affiliation: Key laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, PR China.
authors.forename: Xu-Fan
authors.initials: XF
authors.lastname: Wang
authors.forename: Liang
authors.initials: L
authors.lastname: Peng
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Yang
authors.forename: Liang-Qiu
authors.initials: LQ
authors.lastname: Lu
authors.forename: Feng-Long
authors.initials: FL
authors.lastname: Gu
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D003432:Cross-Linking Reagents; D009574:Nitro Compounds