title: A new compound, jolynamine, from marine brown alga Jolyna laminarioides.
abstract: A new compound, jolynamine (1), was isolated from the marine brown alga Jolyna laminarioides collected from the coast of Karachi, Pakistan. In addition, four known compounds, namely saringosterol (2), loliolide (3), methyl-4-hydroxybenzoate (4) and propyl-4-hydroxybenzoate (5), were isolated for the first time from the marine brown alga Iyengaria stellata, and two known compounds, namely 3,4,5-trimethylaniline (6) and harmine (7), were isolated for the first time from the marine brown alga Melanothamnus afaqhusainii. Compound 6 is synthetically known but was isolated for the first time from a natural source. The structures of these compounds were elucidated with the help of powerful spectroscopic techniques. Furthermore, the methanolic extracts of both algae showed anti-microbial activities against various bacteria and fungi.
authors.affiliation: Research Laboratory of Medicinal Chemistry and Bioenergy (RLMCB), Department of Chemistry, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi 75300, Pakistan. drmajeed_fuuast@yahoo.com
authors.forename: Abdul Majeed
authors.initials: AM
authors.lastname: Khan
authors.forename: Sumaira
authors.initials: S
authors.lastname: Noreen
authors.forename: Zeba Parween
authors.initials: ZP
authors.lastname: Imran
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006247:Harmine / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D015394:Molecular Structure; D010154:Pakistan; D000459:Phaeophyceae / Q000737:chemistry*; D013297:Streptococcus pyogenes / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000814:Aniline Compounds; D000890:Anti-Infective Agents; D026121:Indole Alkaloids; C559762:jolynamine; D006247:Harmine