title: Ultra-wide-field green-light (532-nm) autofluorescence imaging in chronic Vogt-Koyanagi-Harada disease.
abstract: OBJECTIVE
  To assess the prevalence of peripheral fundus autofluorescence (FAF) abnormalities in chronic Vogt-Koyanagi-Harada disease (VKH).
  
  
  METHODS
  A retrospective review of cases at the Doheny Eye Institute between December 2009 and April 2010. Patients with chronic VKH who had ultra-wide-field FAF and pseudo-color imaging performed were included. All images were reviewed independently by two reading center certified retina specialists.
  
  
  RESULTS
  Twenty eyes of 10 patients were included in this analysis. Fourteen eyes of 7 patients (70%) showed peripheral changes on FAF images outside the posterior pole. Three different patterns were observed: multifocal hypofluorescent spots (n = 11 eyes), hyperfluorescent spots (n = 8 eyes), and a unique lattice-like pattern in both eyes of one patient. There were noticeable disparities between FAF and color images.
  
  
  CONCLUSIONS
  Peripheral FAF abnormalities are frequent in chronic VKH and are readily revealed by wide-field FAF imaging and manifesting with distinct patterns. Further investigation in prospective studies is warranted.
authors.affiliation: Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Florian M
authors.initials: FM
authors.lastname: Heussen
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Vasconcelos-Santos
authors.forename: Rajeev R
authors.initials: RR
authors.lastname: Pappuru
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Walsh
authors.forename: Narsing A
authors.initials: NA
authors.lastname: Rao
authors.forename: Srinivas R
authors.initials: SR
authors.lastname: Sadda
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D005453:Fluorescence; D005654:Fundus Oculi; D006801:Humans; D007834:Lasers; D008062:Lipofuscin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019721:Ophthalmoscopes; D012164:Retinal Diseases / Q000175:diagnosis* / Q000378:metabolism; D055213:Retinal Pigment Epithelium / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D008062:Lipofuscin