title: Dyssynchrony contributes to false-positive myocardial perfusion SPECT results in patients with stable angina.
abstract: OBJECTIVE
  We designed this study to evaluate the possibility that dyssynchrony might lead to false-positive myocardial perfusion single photon emission computed tomography myocardial perfusion image (MPS) results in stable angina patients.
  
  
  RESULTS
  This study included 61 patients with both clinically diagnosed stable angina and quantitative MPS results who underwent coronary angiography. The patients were divided into two groups: those who had positive MPS results and normal coronary angiography (Group I, n = 28, 64.05 ± 10.14 years, 11 males and 17 females) and those who had positive MPS results and significant coronary lesions as determined by coronary angiography (Group II, n = 33, 69.2 ± 10.4 years, 14 males and 19 females). The maximal difference in time-to-peak myocardial sustained systolic velocity among all 12 left ventricular (LV) segments (maximal difference in TS) was significantly delayed in Group I as compared with Group II (125.00 ± 46.10 vs. 87.33 ± 40.53 ms, P=0.001). The standard deviation of the time-to-peak myocardial sustained systolic velocity of all 12 LV segments (TS-SD) was also significantly different in the two groups (45.12 ± 19.25 vs. 30.10 ± 15.80 , P=0.002).
  
  
  CONCLUSIONS
  Dyssynchrony may be a cause of false-positive quantitative MPS results, even if patients have narrow QRS complexes on ECG. Dyssynchrony index can increase the specificity of quantitative MPS in stable angina patients.
authors.affiliation: Department of Internal Medicine, Cardiovascular Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea College of Medicine, Seoul 137-701, Republic of Korea.
authors.forename: Jung Sun
authors.initials: JS
authors.lastname: Cho
authors.forename: Ho-Joong
authors.initials: HJ
authors.lastname: Youn
authors.forename: Eun-Joo
authors.initials: EJ
authors.lastname: Cho
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Her
authors.forename: Ju Yeal
authors.initials: JY
authors.lastname: Baek
authors.forename: Mahn-Won
authors.initials: MW
authors.lastname: Park
authors.forename: Sung Gyu
authors.initials: SG
authors.lastname: Yoon
authors.forename: Jeong U
authors.initials: JU
authors.lastname: Baeg
authors.forename: Chan Seok
authors.initials: CS
authors.lastname: Park
authors.forename: Mi-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hae-Ok
authors.initials: HO
authors.lastname: Jung
authors.forename: Hui-Kyung
authors.initials: HK
authors.lastname: Jeon
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000473:pathology*; D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / Q000295:instrumentation / Q000379:methods*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D055414:Myocardial Perfusion Imaging / Q000295:instrumentation / Q000379:methods*; D017256:Technetium Tc 99m Sestamibi; D014463:Ultrasonography
chemical_list: D017256:Technetium Tc 99m Sestamibi