title: DIANA-microT Web server upgrade supports Fly and Worm miRNA target prediction and bibliographic miRNA to disease association.
abstract: microRNAs (miRNAs) are small endogenous RNA molecules that are implicated in many biological processes through post-transcriptional regulation of gene expression. The DIANA-microT Web server provides a user-friendly interface for comprehensive computational analysis of miRNA targets in human and mouse. The server has now been extended to support predictions for two widely studied species: Drosophila melanogaster and Caenorhabditis elegans. In the updated version, the Web server enables the association of miRNAs to diseases through bibliographic analysis and provides insights for the potential involvement of miRNAs in biological processes. The nomenclature used to describe mature miRNAs along different miRBase versions has been extensively analyzed, and the naming history of each miRNA has been extracted. This enables the identification of miRNA publications regardless of possible nomenclature changes. User interaction has been further refined allowing users to save results that they wish to analyze further. A connection to the UCSC genome browser is now provided, enabling users to easily preview predicted binding sites in comparison to a wide array of genomic tracks, such as single nucleotide polymorphisms. The Web server is publicly accessible in www.microrna.gr/microT-v4.
authors.affiliation: Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, 16672, Vari, Greece.
authors.forename: Manolis
authors.initials: M
authors.lastname: Maragkakis
authors.forename: Thanasis
authors.initials: T
authors.lastname: Vergoulis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Alexiou
authors.forename: Martin
authors.initials: M
authors.lastname: Reczko
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Plomaritou
authors.forename: Mixail
authors.initials: M
authors.lastname: Gousis
authors.forename: Kornilios
authors.initials: K
authors.lastname: Kourtis
authors.forename: Nectarios
authors.initials: N
authors.lastname: Koziris
authors.forename: Theodore
authors.initials: T
authors.lastname: Dalamagas
authors.forename: Artemis G
authors.initials: AG
authors.lastname: Hatzigeorgiou
mesh_terms: D000818:Animals; D001634:Bibliographies as Topic; D017173:Caenorhabditis elegans / Q000235:genetics*; D004194:Disease / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D020407:Internet; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D012984:Software
chemical_list: D035683:MicroRNAs