title: Up-regulation of nm23/NDP kinase expression in regenerating hepatocytes.
abstract: We analyzed the kinetics and subcellular localization of nm23-M1 and nm23-M2 in in vivo proliferating mouse liver cells after partial hepatectomy. Along with the regenerative growth rate measured by mitotic index, the expression of both nm23-M1 and nm23-M2 was altered with distinct kinetics. Among the subcellular fractions of regenerating hepatocytes, the increase in the quantity of nm23-M1 and nm23-M2 was the most dominant in the nuclear fractions. In in vitro proliferating human hepatocellular carcinoma cells (PLC/PRF/5) stimulated by hepatocyte growth factor, both nm23-H1 and nm23-H2 were dominantly accumulated around nuclear membranes.
authors.affiliation: MIE UNIV,SCH MED,DEPT INTERNAL MED 2,TSU,MIE 514,JAPAN. KEIMYUNG UNIV,SCH MED,DEPT ANAT,TAEGU,SOUTH KOREA. NAGASAKI UNIV,SCH MED,DEPT ONCOL,NAGASAKI 852,JAPAN.
authors.forename: H
authors.initials: H
authors.lastname: Lee
authors.forename: K
authors.initials: K
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Baba
authors.forename: K
authors.initials: K
authors.lastname: Furukawa
authors.forename: S
authors.initials: S
authors.lastname: Chang
authors.forename: H
authors.initials: H
authors.lastname: Shiku