title: Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy.
abstract: The force analysis between a macrocyclic hexazole (6OTD) monomer/dimer and telomeric DNA using atomic force microscopy revealed the difference in their binding modes. The 6OTD dimer bound to the G-quadruplex more strongly than the monomer by sandwiching the G-quadruplex.
authors.affiliation: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Amemiya
authors.forename: Yui
authors.initials: Y
authors.lastname: Furunaga
authors.forename: Keisuke
authors.initials: K
authors.lastname: Iida
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tera
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ikebukuro
authors.forename: Chikashi
authors.initials: C
authors.lastname: Nakamura
mesh_terms: D054856:G-Quadruplexes; D006801:Humans; D018625:Microscopy, Atomic Force; D010080:Oxazoles / Q000378:metabolism*; D016615:Telomere / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D010080:Oxazoles; C431888:telomestatin