title: Potassium hydroxide/dimethyl sulfoxide promoted intramolecular cyclization for the synthesis of benzimidazol-2-ones.
abstract: A new protocol for intramolecular N-arylations of ureas to form benzimidazol-2-ones has been developed. The cyclization reaction occurs in the presence of KOH and DMSO at close to ambient temperature. Under these conditions the yields are high and a wide range of functional groups are tolerated.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Aachen, Germany.
authors.forename: Astrid
authors.initials: A
authors.lastname: Beyer
authors.forename: Christine M M
authors.initials: CM
authors.lastname: Reucher
authors.forename: Carsten
authors.initials: C
authors.lastname: Bolm
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D006878:Hydroxides / Q000737:chemistry*; D015394:Molecular Structure; D017680:Potassium Compounds / Q000737:chemistry*; D014508:Urea / Q000737:chemistry*
chemical_list: D001562:Benzimidazoles; D006878:Hydroxides; D017680:Potassium Compounds; C053110:benzimidazol-2-one; D014508:Urea; C029943:potassium hydroxide; D004121:Dimethyl Sulfoxide