title: Vascular mechanisms of cyanidin-3-glucoside response in streptozotocin-diabetic rats.
abstract: OBJECTIVE
  Considering the high incidence of cardiovascular disorders in diabetes mellitus and some evidence on the antioxidant and antidiabetic potential of cyanidin-3-glucoside (C3G), this study was conducted to evaluate the possible beneficial effect of C3G administration on vascular reactivity of isolated thoracic aorta in diabetic rats and some of its underlying mechanisms.
  
  
  METHODS
  Male diabetic rats received C3G (10mg/kg; i.p.) on alternate days for 8 weeks one week after streptozotocin (STZ) diabetes induction.
  
  
  RESULTS
  It was found out that treatment of diabetic rats with C3G exerted a hypoglycaemic effect and attenuated the increased malondialdehyde (MDA) content and reduced the activity of superoxide dismutase (SOD) in aortic tissue. Maximum contractile response of endothelium-intact aortic rings to phenylephrine (PE) was significantly lower in C3G-treated diabetic rats relative to untreated diabetics and endothelium removal abolished this difference. Meanwhile, endothelium-dependent relaxation to acetylcholine (ACh) was significantly higher in C3G-treated diabetic rats as compared to diabetic group.
  
  
  CONCLUSIONS
  Chronic treatment with C3G may prevent some diabetes-related changes in vascular reactivity observed in diabetic rats directly and/or indirectly due to its hypoglycaemic effect and attenuation of lipid peroxidation and through endothelial-derived factors.
authors.affiliation: Department of Biology, PayamNoor University, Tehran, Iran.
authors.forename: Sima
authors.initials: S
authors.lastname: Nasri
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Roghani
authors.forename: Tourandokht
authors.initials: T
authors.lastname: Baluchnejadmojarad
authors.forename: Tahereh
authors.initials: T
authors.lastname: Rabani
authors.forename: Mahboubeh
authors.initials: M
authors.lastname: Balvardi