title: Rodent p53 suppresses the transforming activity of the activated Neu oncogene by modulating the Basal promoter activity of Neu.
abstract: The rat neu oncogene encodes a dominant transforming oncogene. The mouse wild-type p53 suppresses the transforming activity of the neu oncogene while different p53 mutants demonstrate varying ability to repress neu-induced transformation. Suppression of neu-transforming activity is due to inhibition of transcription. Deletion analysis of the rat neu promoter shows that p53 represses the basal promoter activity of neu. Therefore, rodent p53 suppresses the transforming potential of neu by inhibiting transcription from the basal promoter of neu.
authors.affiliation: UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT TUMOR BIOL,HOUSTON,TX 77030. NATL DEF MED CTR,DEPT BIOCHEM,TAIPEI 10764,TAIWAN.
authors.forename: A
authors.initials: A
authors.lastname: Matin
authors.forename: Y
authors.initials: Y
authors.lastname: Xie
authors.forename: M
authors.initials: M
authors.lastname: Kao
authors.forename: M
authors.initials: M
authors.lastname: Hung