title: A comparison of stochastic variation in mixed and unmixed casework and synthetic samples.
abstract: Understanding the behaviour of mixed DNA profiles is of paramount importance in forensic DNA analysis. Key parameters are those of heterozygote balance and mixture proportion and its variability. These parameters have been previously explored as a function of the average peak height of the active alleles in single source and mixed samples derived from pristine DNA. Here we report a comparison of this data with data obtained from casework samples. This allows an assessment of the difference in the distribution of heterozygote balance between mixed and single source stains and between casework mixtures and synthetic mixtures constructed from pristine DNA.
authors.affiliation: ESR, Private Bag 92021, Auckland, New Zealand. jo.bright@esr.cri.nz
authors.forename: Jo-Anne
authors.initials: JA
authors.lastname: Bright
authors.forename: Kurt
authors.initials: K
authors.lastname: McManus
authors.forename: SallyAnn
authors.initials: S
authors.lastname: Harbison
authors.forename: Peter
authors.initials: P
authors.lastname: Gill
authors.forename: John
authors.initials: J
authors.lastname: Buckleton
mesh_terms: D000483:Alleles; D053523:Amelogenin / Q000235:genetics; D004247:DNA / Q000235:genetics*; D016172:DNA Fingerprinting; D056426:Genetic Loci; D006579:Heterozygote; D006801:Humans; D012044:Regression Analysis
chemical_list: D053523:Amelogenin; D004247:DNA