title: Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan-induced pleurisy in rats.
abstract: Accumulative evidences have showed that some coumarin derivatives have significantly anti-inflammatory effects. To investigate the potential anti-inflammatory effect of compound IMMLG5521, a novel coumarin derivative, carrageenan-induced pleurisy model in rats was employed. The results showed that IMMLG5521 (5, 10 and 20 mg/kg) exhibited anti-inflammatory effects, reducing pleural exudate formation, decreasing total number of inflammation cells and polymorphonuclear leukocytes infiltration, attenuating histological injury and reducing TNF-α, IL-1β, MIP-2 and IL-8 release. Further investigation revealed that the compound may exert its anti-inflammatory effect via inhibiting nuclear translocation of NF-кB in inflammatory cells collected from pleural exudates. Taken together, the present results suggested that IMMLG5521 inhibited acute inflammation in carrageenan-induced pleurisy model that could be, in part, related to a reduction of release of inflammatory factors, another part may be related to an inhibition of NF-кB activation.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Li
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
authors.forename: Ming-Na
authors.initials: MN
authors.lastname: Sun
authors.forename: Hai-Jie
authors.initials: HJ
authors.lastname: Ji
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Dong-Hui
authors.initials: DH
authors.lastname: Wu
authors.forename: Guang-Yan
authors.initials: GY
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Nai-Hong
authors.initials: NH
authors.lastname: Chen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology* / Q000627:therapeutic use; D016207:Cytokines / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D035422:Pleural Cavity / Q000187:drug effects / Q000378:metabolism; D010998:Pleurisy / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D003374:Coumarins; D016207:Cytokines; C561127:IMMLG5521; D016328:NF-kappa B; D002351:Carrageenan; D009195:Peroxidase