title: Determination of clomipramine by flow-injection analysis with acidic potassium permanganate-formic acid chemiluminescence detection.
abstract: A sensitive and simple chemiluminescent (CL) method for the determination of clomipramine has been developed by combining the flow-injection analysis (FIA) technique, which is based on the CL intensity generated from the redox reaction of potassium permanganate (KMnO(4))-formic acid in sulphuric acid (H(2)SO(4)) medium. Under the optimum conditions, the linear range for the determination of clomipramine was 0.04-4 µg/mL, with a correlation coefficient of 0.9988 (n = 10) and a detection limit of 0.008 µg/mL (3σ), and the relative standard deviation (RSD) for 2.0 µg/mL clomipramine (n = 11) is 1.26%. The proposed method has been successfully applied to the determination of the studied clomipramine in pharmaceutical preparations. The possible reaction mechanism is discussed.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People's Republic of China.
authors.forename: Zhongling
authors.initials: Z
authors.lastname: Ji
authors.forename: Xun
authors.initials: X
authors.lastname: Yao
authors.forename: Jianguo
authors.initials: J
authors.lastname: Li
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000737:chemistry*; D002997:Clomipramine / Q000032:analysis*; D017022:Flow Injection Analysis / Q000379:methods*; D005561:Formates / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D049449:Luminescence; D011196:Potassium Permanganate / Q000737:chemistry*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D005561:Formates; D011196:Potassium Permanganate; C030544:formic acid; D002997:Clomipramine