title: Changes in self-reported hot flashes and their association with concurrent changes in insomnia symptoms among women with breast cancer.
abstract: OBJECTIVE
  The aim of this study was to assess longitudinally the relationship between hot flashes and insomnia symptoms in women receiving adjuvant treatments for breast cancer.
  
  
  METHODS
  Fifty-eight participants completed a 7-day daily diary assessing hot flashes, the Menopause-Specific Quality of Life Questionnaire, and the Insomnia Severity Index, before and after chemotherapy or radiotherapy and at a 3-month follow-up evaluation.
  
  
  RESULTS
  A first canonical correlation analysis (n = 55) revealed a marginally significant relationship between pretreatment versus posttreatment change scores in hot flashes and sleep (R = 0.39), and a second analysis (n = 51) showed a significant relationship between posttreatment and follow-up changes in hot flash activity and sleep (R = 0.59).
  
  
  CONCLUSIONS
  These results show that increases in vasomotor symptoms occurring within the few months after the termination of initial adjuvant treatments for breast cancer are significantly associated with concurrent increases in insomnia symptoms and vice versa.
authors.affiliation: École de psychologie, Université Laval, Québec, Canada.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Savard
authors.forename: Josée
authors.initials: J
authors.lastname: Savard
authors.forename: Claudia
authors.initials: C
authors.lastname: Trudel-Fitzgerald
authors.forename: Hans
authors.initials: H
authors.lastname: Ivers
authors.forename: Catherine
authors.initials: C
authors.lastname: Quesnel
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000503:physiopathology* / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D019584:Hot Flashes / Q000503:physiopathology*; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D011788:Quality of Life; D057566:Self Report; D012720:Severity of Illness Index; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology*
chemical_list: D000970:Antineoplastic Agents