title: DNA-directed self-assembly of graphene oxide with applications to ultrasensitive oligonucleotide assay.
abstract: Controlled graphene or its derivatives' assembly is of growing interest in many areas. However, achieving control over their assembly into precise and predictable architectures has been challenging and is still a bottleneck to their utilization. Herein, we report for the first time the use of DNA hybridization for the controllable assembly of a graphene nanosheet. Moreover, with the help of dynamic light scattering technique, we extended the above studies by exploiting the DNA-graphene dispersed sheets as highly ultrasensitive detection of oligonuleotides for the fabrication of a novel biosensing strategy, which shows high sensitivity and excellent selectivity. This work will show a new general route to graphene-based lamellar composite materials and would bring about advances in the research of graphene-based biofunctional materials for specific applications in biodiagnostics, nanoelectronics, and bionanotechnology.
authors.affiliation: Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: Longhua
authors.initials: L
authors.lastname: Tang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Jinghong
authors.initials: J
authors.lastname: Li
mesh_terms: D004247:DNA / Q000737:chemistry*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006108:Graphite / Q000737:chemistry*; D017403:In Situ Hybridization / Q000295:instrumentation*; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation*; D010087:Oxides / Q000737:chemistry*
chemical_list: D010087:Oxides; D006108:Graphite; D004247:DNA