title: Differential regulation of glucose transporter-1 and -2 gene expression by hepatocyte growth factor in human hepatoblastoma cells.
abstract: Glucose transporters, GLUT-1 and GLUT-2, are key factors involved in facilitative glucose transport to hepatocytes. The aim of the present study was to clarify how hepatocyte growth factor (HGF) regulates expression of both genes in HepG2 human hepatoblastoma cells. HGF dose-dependently suppressed cell growth, but enhanced cellular glucose uptake together with increased expression of GLUT-1 protein. This increase resulted from elevation of its transcript. In contrast, no changes were found in expression of GLUT-2 protein or its transcript by HGF treatment. These results indicate that HGF stimulates glucose incorporation through the selective up-regulation of GLUT-1 gene expression in HepG2 cells.
authors.affiliation: NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 1,NAGASAKI 852,JAPAN. NAGASAKI UNIV,HLTH RES CTR,NAGASAKI 852,JAPAN.
authors.forename: T
authors.initials: T
authors.lastname: Ueki
authors.forename: K
authors.initials: K
authors.lastname: Nakata
authors.forename: F
authors.initials: F
authors.lastname: Mawatari
authors.forename: H
authors.initials: H
authors.lastname: Yamasaki
authors.forename: S
authors.initials: S
authors.lastname: Tsuruta
authors.forename: A
authors.initials: A
authors.lastname: Ido
authors.forename: K
authors.initials: K
authors.lastname: Nakao
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Nagataki