title: Pregnant women affected by thalassemia major: a controlled study of traits and personality.
abstract: BACKGROUND
  The reproductive and sexual health issues concerning persons affected by thalassemia major are complex. The study was planned to investigate the psychological attitudes and expectations in a group of thalassemic pregnant women attending hospital for regular blood transfusion.
  
  
  METHODS
  This is a preliminary cross-sectional study involving 20 consecutive thalassemic patients and a control group of 42 healthy pregnant volunteers. The personality structure was evaluated by Rorschach's test and the presence of psychic symptoms by SCL-90-R and STAI.
  
  
  RESULTS
  Narcissism and sexual traumas are significantly higher in thalassemic women with respects to the control group. Also the percent of anxiety and depression observed with the SCL-90-R was significantly higher than in control group (45% vs. 3%, p < 0.001, mean and SD values are 1.65 ± 0.15 vs. 0.43 ± 0.18 for anxiety; 55% vs. 12%, p < 0.001, mean and SD values are 1.76 ± 0.18 vs. 0.85 ± 0.25 for depression). The score observed with the STAI shows that the trait of anxiety differed between thalassemic pregnant women and the control group, even though the score values aren't pathologic in neither group (87% vs. 42%, p < 0.05, mean and SD values are 33 ± 0.8 vs. 22 ± 0.2).
  
  
  CONCLUSIONS
  This study addresses the need for developing, implementing and evaluating proper psychological support for thalassemic pregnant patients. Moreover, psychological screening and support prior to, during and following pregnancy would be indicated.
authors.affiliation: Hereditary Anemia Center, Department of Internal Medicine, Policlinico Foundation IRCCS, University of Milan, Milan, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Messina
authors.forename: Elisa
authors.initials: E
authors.lastname: Colombo
authors.forename: Elena
authors.initials: E
authors.lastname: Cassinerio
authors.forename: Claudia
authors.initials: C
authors.lastname: Cesaretti
authors.forename: Alessia
authors.initials: A
authors.lastname: Marcon
authors.forename: Laura
authors.initials: L
authors.lastname: Zanaboni
authors.forename: Marina
authors.initials: M
authors.lastname: Baldini
authors.forename: Maria Domenica
authors.initials: MD
authors.lastname: Cappellini