title: Evaluation of the relative efficacy of copolymerized polylactic-polyglycolic acids alone and in conjunction with polyglactin 910 membrane in the treatment of human periodontal infrabony defects: a clinical and radiological study.
abstract: BACKGROUND
  Absorbable synthetic biopolymers have been used as bone filler in Periodontology, proving effective stimulants to bone regeneration.
  
  
  OBJECTIVE
  Copolymerized polylactic and polyglycolic acid is used as a bone filler and polyglactin 910 as a guided tissue regeneration (GTR) membrane to achieve regeneration in periodontal infrabony defects.
  
  
  METHODS
  Forty patients with two- or three-walled infrabony defects were selected and randomly divided into two groups. Group A included patients treated with polylactic-polyglycolic acids 50:50 (Fisiograft ,Ghimsa SPA,Via Fucini, Italy) alone and Group B included patients treated with polylactic-polyglycolic acids (PLA-PGA)50:50 in conjunction with polyglactin acid 910 (Vicryl Mesh Johnson&Johnson , U.S.A ). Evaluation of clinical parameters probing depth and attachment level and radiographs was done preoperatively and 12 and 24 weeks postoperatively.
  
  
  RESULTS
  Both the groups showed statistically significant mean reduction in probing depth and gain in clinical attachment level and linear bone fill.
  
  
  CONCLUSIONS
  Within the limit of this study, both the treatment modalities are beneficial for the treatment of infrabony defects.
authors.affiliation: Department of Periodontics and Implantology, BRS Dental College and Hospital, Barwala, Panchkula, India.
authors.forename: Vipin
authors.initials: V
authors.lastname: Chhabra
authors.forename: Amarjit Singh
authors.initials: AS
authors.lastname: Gill
authors.forename: Poonam
authors.initials: P
authors.lastname: Sikri
authors.forename: Nandini
authors.initials: N
authors.lastname: Bhaskar
mesh_terms: D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D001672:Biocompatible Materials / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000627:therapeutic use*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D019344:Lactic Acid / Q000627:therapeutic use*; D008567:Membranes, Artificial; D010510:Periodontal Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D011098:Polyglactin 910 / Q000627:therapeutic use*; D011100:Polyglycolic Acid / Q000627:therapeutic use*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D008567:Membranes, Artificial; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011098:Polyglactin 910