title: Factors associated with irritable bowel syndrome symptoms in hemodialysis patients.
abstract: OBJECTIVE
  To investigate clinical characteristics associated with the presence of irritable bowel syndrome (IBS) symptoms in hemodialysis (HD) patients.
  
  
  METHODS
  This was a cross-sectional study. A questionnaire based on the Bowel Disease Questionnaire that records gastrointestinal symptoms was given to 294 patients in 4 dialysis centers. A total of 196 (67%) subjects returned the survey. A multivariable logistic regression model was used to identify factors significantly associated with IBS symptoms.
  
  
  RESULTS
  Symptoms compatible with IBS were present in 27 (13.8%) subjects and independently associated with low post-dialysis serum potassium [OR = 0.258, 95% CI (0.075-0.891), P = 0.032], paracetamol use [OR = 3.159, 95% CI (1.214-8.220), P = 0.018], and Kidney Disease Quality of Life (KDQOL) cognitive function score [OR = 0.977, 95% CI (0.956-0.999), P = 0.042]. Univariate regressions were also performed and the reported significance is for multivariate analysis. No association was detected for age, gender, depressed mood, smoking (present or past), body mass index, albumin level, Kt/V, sodium pre- or post-dialysis level, change in potassium level during HD, proton pump inhibitor or H2 blocker use, aspirin use, residual diuresis, hepatitis B or C infection, diabetes mellitus, marital status and education level.
  
  
  CONCLUSIONS
  This study examined potential risk factors for symptoms compatible with IBS in HD patients and identified an association with paracetamol use, post-dialysis potassium level and KDQOL-cognitive function score.
authors.affiliation: Department of Internal Medicine, Nephrology and Transplantation Medicine, Central Clinical Hospital of Ministry of Home Affairs, 02-507 Warsaw, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Fiderkiewicz
authors.forename: Alicja
authors.initials: A
authors.lastname: Rydzewska-Rosołowska
authors.forename: Michał
authors.initials: M
authors.lastname: Myśliwiec
authors.forename: Magdalena
authors.initials: M
authors.lastname: Birecka
authors.forename: Bożenna
authors.initials: B
authors.lastname: Kaczanowska
authors.forename: Grażyna
authors.initials: G
authors.lastname: Rydzewska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Rydzewski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D011795:Surveys and Questionnaires