title: DIC and granulomatous vasculitis in a dog with disseminated histoplasmosis.
abstract: Disseminated histoplasmosis and disseminated intravascular coagulopathy were diagnosed in a 7 mo old, female spayed mixed-breed dog. The dog improved transiently with supportive care, but deteriorated shortly after initiation of antifungal therapy. The dog was subsequently euthanized. At necropsy, marked granulomatous vasculitis was identified in all affected organs. The tunicae and laminae of the arteries and arterioles were obscured by epithelioid macrophages and multinucleated giant cells admixed with necrotic material. Intracytoplasmic yeast were present within some of these macrophages. To the authors' knowledge, this is the first reported case of granulomatous vasculitis associated with Histoplasma capsulatum in a dog.
authors.affiliation: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA. shirchen69@yahoo.com
authors.forename: Chen
authors.initials: C
authors.lastname: Gilor
authors.forename: Marcella D
authors.initials: MD
authors.lastname: Ridgway
authors.forename: Kuldeep
authors.initials: K
authors.lastname: Singh
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000382:microbiology / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006660:Histoplasmosis / Q000473:pathology / Q000662:veterinary*; D014657:Vasculitis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*