title: Fate of chlortetracycline in Korean arable soil.
abstract: The widespread use of the pharmaceutical chlortetracycline to treat human and animal infectious diseases is raising concern in Korea regarding the potential development of antibiotic-resistant bacteria. This study investigated the fate of chlortetracycline in Korean arable soils, to assess its environmental impact. The estimated half-life of chlortetracycline was 26.70-27.17 days indoors and 18.63-30.16 days outdoors. The chlortetracycline epimers and metabolites, 4-epichlortetracycline and 4-epi-anydrochlotetracycline were determined using liquid chromatography tandem mass spectroscopy. The respective concentrations of 4-epi-anydrochlotetracycline and 4-epichlortetracycline were 1.91%-9.71% and 11.12%-23.92% of the total chlortetracycline residual concentration indoors and 2.96%-11.44% and 17.61%-40.73% outdoors.
authors.affiliation: National Veterinary Research & Quarantine Service (NVRQS), 620-2 Amnam-dong, Seo-gu, Busan, Republic of Korea. jinwook@korea.kr
authors.forename: Jin-Wook
authors.initials: JW
authors.lastname: Kwon
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry*; D002751:Chlortetracycline / Q000032:analysis / Q000737:chemistry*; D002853:Chromatography, Liquid; D004784:Environmental Monitoring / Q000379:methods; D006207:Half-Life; D008372:Manure / Q000032:analysis; D013058:Mass Spectrometry; D056910:Republic of Korea; D012987:Soil / Q000737:chemistry*; D012989:Soil Pollutants / Q000032:analysis / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D008372:Manure; D012987:Soil; D012989:Soil Pollutants; D002751:Chlortetracycline