title: Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome.
abstract: Hypocortisolism is a frequent finding in individuals with chronic fatigue syndrome (CFS) with other research findings implying potential dysregulation of glucocorticoid signaling. Glucocorticoid signaling is under the influence of several pathways, several of which are of interest in the study of CFS. Oxidative stress and decreased antioxidant capacity are known to disrupt the hypothalamic-pituitary-adrenal (HPA) axis (Epel et al., 2004) and the presence of histone deacetylases (HDAC) could also impact glucocorticoid signaling. The intent of this pilot study was to investigate the relationship among oxidative stress elements, select HDAC's (2/3) and glucocorticoid receptor signaling in an elderly sample with CFS. Findings suggest increased histone deacetylase activity, lower total antioxidant power, in the context of decreased plasma cortisol and increased plasma dehydroepiandrosterone concomitant with decreased expression of the encoding gene for the glucocorticoid receptor. These findings support the presence of HPA axis dysregulation in elderly individuals with CFS.
authors.affiliation: Department of Psychology, DePaul University, Chicago, IL 60614, United States.
authors.forename: Leonard
authors.initials: L
authors.lastname: Jason
authors.forename: Matthew
authors.initials: M
authors.lastname: Sorenson
authors.forename: Kebba
authors.initials: K
authors.lastname: Sebally
authors.forename: Dalal
authors.initials: D
authors.lastname: Alkazemi
authors.forename: Athena
authors.initials: A
authors.lastname: Lerch
authors.forename: Nicole
authors.initials: N
authors.lastname: Porter
authors.forename: Stan
authors.initials: S
authors.lastname: Kubow
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000097:blood; D015673:Fatigue Syndrome, Chronic / Q000097:blood*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D006655:Histone Deacetylases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000502:physiology; D012313:RNA / Q000032:analysis / Q000235:genetics
chemical_list: D000975:Antioxidants; D009414:Nerve Growth Factors; D003687:Dehydroepiandrosterone; D012313:RNA; D006655:Histone Deacetylases; D006854:Hydrocortisone