title: Heart transplantation in pediatric patients: twelve-year experience of the Asan Medical Center.
abstract: Heart transplantation is a standard treatment for end-stage heart disease. Pediatric heart transplantation, however, is not frequently performed due to the shortage of pediatric heart donors. This is the first report of pediatric heart transplantation in Korea. Our retrospective study included 37 patients younger than 18 yr of age who underwent heart transplantation at Asan Medical Center between August 1997 and April 2009. Preoperative diagnosis was either cardiomyopathy (n = 29, 78.3%) or congenital heart disease (n = 8, 22.7%). Mean follow up period was 56.9 ± 44.6 months. There were no early death, but 7 late deaths (7/37, 18.9%) due to rejection after 11, 15, 41 months (n = 3), infection after 5, 8, 10 months (n = 3), suspicious ventricular arrhythmia after 50 months (n = 1). There was no significant risk factor for survival. There were 25 rejections (25/37, 67.6%); less than grade II occurred in 17 patients (17/25, 68%) and more than grade II occurred in 8 patients (8/25, 32%). Actuarial 1, 5, and 10 yr survival was 88.6%, 76.8%, and 76.8%. Our midterm survival of pediatric heart transplantation showed excellent results. We hope this result could be an encouraging message to do more pediatric heart transplantation in Korean society.
authors.affiliation: Division of Pediatric Cardiac Surgery, Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Hong Ju
authors.initials: HJ
authors.lastname: Shin
authors.forename: Won Kyoung
authors.initials: WK
authors.lastname: Jhang
authors.forename: Jeong-Jun
authors.initials: JJ
authors.lastname: Park
authors.forename: Tae Jin
authors.initials: TJ
authors.lastname: Yun
authors.forename: Young Hwee
authors.initials: YH
authors.lastname: Kim
authors.forename: Jae Joong
authors.initials: JJ
authors.lastname: Kim
authors.forename: Meong-Gun
authors.initials: MG
authors.lastname: Song
authors.forename: Dong Man
authors.initials: DM
authors.lastname: Seo
mesh_terms: D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000401:mortality; D009202:Cardiomyopathies / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection / Q000401:mortality; D006330:Heart Defects, Congenital / Q000601:surgery; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007223:Infant; D007239:Infections / Q000401:mortality; D008297:Male; D011183:Postoperative Complications; D056910:Republic of Korea; D012189:Retrospective Studies; D014019:Tissue Donors; D016896:Treatment Outcome