title: Role of transrectal real-time tissue elastography in the diagnosis of prostate cancer.
abstract: OBJECTIVE
  To investigate the role of transrectal real-time tissue elastography (TRTE) in the diagnosis of prostate cancer (PCa).
  
  
  METHODS
  Eighty-four patients with suspected PCa and scheduled for prostate biopsies underwent TRTE, digital rectal examination (DRE), transrectal ultrasonography (TRUS), and magnetic resonance imaging (MRI). The findings of TRTE were compared with those of other examinations and pathological findings.
  
  
  RESULTS
  Of these 84 patients, 36 had benign lesions and 48 had PCa. The diagnostic sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 91.7%, 72.2%, 83.3%, 81.5%, and 86.7% for TRTE and 85.4%ì63.9%ì76.2%, 75.9%, and 76.7% for TRUS (P>0.05), while its specificity (72.2%) was significantly higher than that of MRI (44.4%) (P=0.03). The TRTE findings were not significantly correlated with the pathological findings and serum total prostate specific antigen (P>0.05), and the diagnostic sensitivity of TRTE decreased along with the enlargement of prostate. However, the diagnostic specificity of TRTE was higher than MRI for nodules with soft to medium texture (P=0.04).For PCa, the diagnostic sensitivity of TRTE increased when the Gleanson scores of tumors increased (P<0.05).
  
  
  CONCLUSIONS
  TRTE can be used as a diagnostic test to supplement clinical diagnosis of PCa.
authors.affiliation: Department of Ultrasound, PLA General HospitalìBeijing 100853, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yan
authors.forename: Tang
authors.initials: T
authors.lastname: Jie
authors.forename: Li
authors.initials: L
authors.lastname: Yan-Mi
authors.forename: Fei
authors.initials: F
authors.lastname: Xiang
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu-Quan
authors.forename: He
authors.initials: H
authors.lastname: En-Hui
authors.forename: Li
authors.initials: L
authors.lastname: Qiu-Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D012007:Rectum / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity