title: Supported TBD-assisted solution phase diversification of formyl-aza-heterocycles through alkylation-knoevenagel one pot sequences.
abstract: An efficient solution-phase parallel procedure to perform the structural diversification of some formyl-nitrogen heterocycles (A) using the reusable TBD supported base is described. The library synthesis is based in a consecutive Alkylation-Knoevenagel functionalisation that uses alkyl halides (B), Michael acceptors (C) and activated methylene compounds (D) as diversity elements.
authors.affiliation: Combinatorial Chemistry Unit (COMBIOMED), Institute of Industrial Pharmacy (IFI), University of Santiago de Compostela, Spain.
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: El Maatougui
authors.forename: A
authors.initials: A
authors.lastname: Crespo
authors.forename: Artur M S
authors.initials: AM
authors.lastname: Silva
authors.forename: Alberto
authors.initials: A
authors.lastname: Coelho
mesh_terms: D000478:Alkylation; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D053961:Azabicyclo Compounds / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D057166:High-Throughput Screening Assays; D015394:Molecular Structure; D012996:Solutions; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds; D053961:Azabicyclo Compounds; D006571:Heterocyclic Compounds; D012996:Solutions; C526482:triazabicyclodecene