title: Current therapeutic strategies for premature ejaculation and future perspectives.
abstract: Premature ejaculation (PE) is a common sexual disorder in men that is mediated by disturbances in the peripheral and central nervous systems. Although all pharmaceutical treatments for PE are currently used 'off-label', some novel oral agents and some newer methods of drug administration now provide important relief to PE patients. However, the aetiology of this condition has still not been unified, primarily because of the lack of a standard animal model for basic research and the absence of a widely accepted definition and assessment tool for evidence-based clinical studies in patients with PE. In this review, we focus on the current therapeutic strategies and future treatment perspectives for PE.
authors.affiliation: Andrology Centre of Peking University First Hospital, Peking University, Beijing 100034, China. xinzc@bjmu.edu.cn
authors.forename: Zhong-Cheng
authors.initials: ZC
authors.lastname: Xin
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Zhu
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Yuan
authors.forename: Wan-Shou
authors.initials: WS
authors.lastname: Cui
authors.forename: Zhe
authors.initials: Z
authors.lastname: Jin
authors.forename: Wei-Ren
authors.initials: WR
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use; D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use; D004338:Drug Combinations; D004542:Ejaculation / Q000502:physiology*; D007172:Erectile Dysfunction / Q000188:drug therapy; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D023421:Models, Animal; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use; D011318:Prilocaine / Q000008:administration & dosage; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*; D020018:Sexual Dysfunctions, Psychological / Q000628:therapy*; D014147:Tramadol / Q000627:therapeutic use
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000928:Antidepressive Agents; D004338:Drug Combinations; D008012:Lidocaine; D058986:Phosphodiesterase 5 Inhibitors; D011318:Prilocaine; D017367:Selective Serotonin Reuptake Inhibitors; D014147:Tramadol