title: Metiram-induced nephrotoxicity in albino mice: effect of licorice aqueous extract.
abstract: The present study was designed to estimate the effect of aqueous extract of licorice on metiram toxicity in mice. Treating mice with metiram at a dose level of [1/2] LD(50) daily for 3 weeks induced many histological changes in the kidney cortex. The renal tubules lost their characteristic appearance and their lining epithelial cells were degenerated. The glomeruli were atrophied and the renal blood vessels were congested. The intertubular spaces infiltrated by inflammatory leukocytic cells. Metiram caused an increase in proliferating cell nuclear antigen (PCNA) expression in nuclei of tubular epithelial cells. Metiram also caused marked elevation in serum creatinine and blood urea nitrogen. Treating animals with metiram and licorice aqueous extract led to an improvement, in both biochemical and histopathological alterations. These results proved that licorice had an ameliorative effect against kidney injury induced by metiram and this effect may be attributed to its antioxidant activity.
authors.affiliation: Department of Zoology, Faculty of Science, Menoufiya University, Shebin El-kom, Egypt. sabsak@yahoo.com
authors.forename: Saber
authors.initials: S
authors.lastname: Sakr
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Kenawy
authors.forename: Doaa
authors.initials: D
authors.lastname: El-Sahra
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004050:Ditiocarb / Q000633:toxicity*; D005659:Fungicides, Industrial / Q000633:toxicity*; D006035:Glycyrrhiza / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051437:Renal Insufficiency / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000975:Antioxidants; D005659:Fungicides, Industrial; D010936:Plant Extracts; D018809:Proliferating Cell Nuclear Antigen; C008971:polymarcine; D004050:Ditiocarb; D003404:Creatinine