title: High aromatase activity and overexpression of epidermal growth factor receptor in fibrolamellar hepatocellular carcinoma in a child.
abstract: An 11-year-old boy was admitted with a liver tumor and underwent right trisegmentectomy for a diagnosis of fibrolamellar hepatocellular carcinoma. He had suffered from bilateral gynecomastia for a year, which improved after complete resection of the tumor. The tumor cells had significant aromatase activity (8.03 pmol/g/h) and contained high levels of estradiol (82.1 pg/mL), which contributed to gynecomastia. Furthermore, overexpression of epidermal growth factor receptor was determined in the tumor cells, which suggests that antitumor strategies using epidermal growth factor receptor antagonists may be effective.
authors.affiliation: Department of Pediatric Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan. c-kmuramori@eph.pref.ehime.jp
authors.forename: Katsumi
authors.initials: K
authors.lastname: Muramori
authors.forename: Syouhei
authors.initials: S
authors.lastname: Taguchi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Taguchi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kohashi
authors.forename: Keizo
authors.initials: K
authors.lastname: Furuya
authors.forename: Kiriko
authors.initials: K
authors.lastname: Tokuda
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishii
mesh_terms: D001141:Aromatase / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000378:metabolism / Q000473:pathology; D002648:Child; D066246:ErbB Receptors / Q000378:metabolism*; D006177:Gynecomastia / Q000209:etiology; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D008297:Male
chemical_list: D001141:Aromatase; D066246:ErbB Receptors