title: LIF-dependent signaling: new pieces in the Lego.
abstract: LIF, a member of the IL6 family of cytokine, displays pleiotropic effects on various cell types and organs. Its critical role in stem cell models (e.g.: murine ES, human mesenchymal cells) and its essential non redundant function during the implantation process of embryos, in eutherian mammals, put this cytokine at the core of many studies aiming to understand its mechanisms of action, which could benefit to medical applications. In addition, its conservation upon evolution raised the challenging question concerning the function of LIF in species in which there is no implantation. We present the recent knowledge about the established and potential functions of LIF in different stem cell models, (embryonic, hematopoietic, mesenchymal, muscle, neural stem cells and iPSC). We will also discuss EVO-DEVO aspects of this multifaceted cytokine.
authors.affiliation: Univ. de Bordeaux, CIRID, UMR5164, F-33000, Bordeaux, France.
authors.forename: Marie-Emmanuelle
authors.initials: ME
authors.lastname: Mathieu
authors.forename: Claire
authors.initials: C
authors.lastname: Saucourt
authors.forename: Virginie
authors.initials: V
authors.lastname: Mournetas
authors.forename: Xavier
authors.initials: X
authors.lastname: Gauthereau
authors.forename: Nadine
authors.initials: N
authors.lastname: Thézé
authors.forename: Vincent
authors.initials: V
authors.lastname: Praloran
authors.forename: Pierre
authors.initials: P
authors.lastname: Thiébaud
authors.forename: Hélène
authors.initials: H
authors.lastname: Bœuf
mesh_terms: D000818:Animals; D015870:Gene Expression; D005786:Gene Expression Regulation; D058685:Genetic Pleiotropy; D006801:Humans; D053605:Leukemia Inhibitory Factor / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53