title: Polymorphism of the thymidylate synthase gene and risk of relapse in childhood ALL.
abstract: Polymorphisms of genes encoding proteins involved in drug metabolism can influence the efficacy of leukemia treatment. In this population-wide study we aimed to evaluate selected, metabolically active genetic polymorphisms as prognostic markers of treatment efficacy in acute lymphoblastic leukemia (ALL). A total of 51 cases of leukemia relapse were diagnosed in a group of 354 patients with ALL. A strong association between promoter tandem repeat polymorphism of the thymidylate synthase gene and the relapse frequency was found. We believe that genotyping for this variant should be performed in patients treated for ALL to enable further optimizing of treatment protocols.
authors.affiliation: Chair of Pediatrics Jagiellonian University, Krakow, Poland.
authors.forename: Jacek J
authors.initials: JJ
authors.lastname: Pietrzyk
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Bik-Multanowski
authors.forename: Szymon
authors.initials: S
authors.lastname: Skoczen
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kowalczyk
authors.forename: Walentyna
authors.initials: W
authors.lastname: Balwierz
authors.lastname: AlicjaChybicka
authors.forename: Michal
authors.initials: M
authors.lastname: Matysiak
authors.forename: Tomasz
authors.initials: T
authors.lastname: Szczepanski
authors.forename: Anna
authors.initials: A
authors.lastname: Balcerska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Bodalski
authors.forename: Maryna
authors.initials: M
authors.lastname: Krawczuk-Rybak
authors.forename: Mariusz
authors.initials: M
authors.lastname: Wysocki
authors.forename: Grazyna
authors.initials: G
authors.lastname: Sobol
authors.forename: Jacek
authors.initials: J
authors.lastname: Wachowiak
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology / Q000235:genetics* / Q000628:therapy; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics; D011446:Prospective Studies; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D020080:Tandem Repeat Sequences / Q000235:genetics; D013940:Thymidylate Synthase / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D013940:Thymidylate Synthase