title: Percutaneous glycerol rhizotomy for trigeminal neuralgia: safety and efficacy of repeat procedures.
abstract: Percutaneous glycerol rhizotomy (PGR) is an established technique to treat trigeminal neuralgia. Our aim was to establish how safe and efficacious repeat glycerol rhizotomies were on a study of 179 PGRs performed in our institution. There was an overall success rate of 92.1% in improvement of facial pain. Nine patients had reduced facial sensation post-operatively. There were no cases of anaesthesia dolorosa. The mean time to repeat injection was 22.9 months (1-108 months). Of those requiring repeat glycerol rhizotomies within 6 months, 23% had multiple sclerosis. There was no evidence that the number of repeat glycerol rhizotomies affects the probability of them having a complication (p = 0.87). Glycerol rhizotomy for trigeminal neuralgia is a safe and efficacious method of pain relief, which is particularly useful in the elderly. It can be repeated many times with no increase in morbidity and most importantly, in our practice, no anaesthesia dolorosa.
authors.affiliation: Department of Neurosurgery, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, United Kingdom. anwen.harries@gmail.com
authors.forename: Anwen M
authors.initials: AM
authors.lastname: Harries
authors.forename: Rosalind D
authors.initials: RD
authors.lastname: Mitchell
mesh_terms: D005260:Female; D005990:Glycerol / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012008:Recurrence; D019233:Retreatment / Q000379:methods; D019051:Rhizotomy / Q000009:adverse effects / Q000379:methods*; D012997:Solvents / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000150:complications / Q000601:surgery* / Q000628:therapy*
chemical_list: D012997:Solvents; D005990:Glycerol