title: The relationship between serum phosphate levels with childhood obesity and insulin resistance.
abstract: OBJECTIVE
  To investigate the relationship between serum phosphate levels with obesity and insulin resistance in childhood.
  
  
  METHODS
  A total of 298 children and adolescents (190 obese subjects and 108 controls) were included in the study. Serum glucose, insulin, phosphate, calcium and alkaline phosphatase levels were measured after 12 h fasting at 08:00-08:30 h. We assessed insulin sensitivity by using the HOMA-IR (homeostasis model of insulin resistance) index as a surrogate marker of insulin resistance.
  
  
  RESULTS
  Serum levels of phosphate were significantly lower in the 6- to 12-year-old obese subjects than controls (p = 0.02, p < 0.05). At the same time, there was a moderate negative correlation between serum phosphate levels and the HOMA-IR index in the 6- to 12-year-old IR (-) obese children (r = -0.26, p = 0.02).
  
  
  CONCLUSIONS
  Low serum phosphate levels could contribute to the development of insulin resistance in 6- to 12-year-old obese children.
authors.affiliation: Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Fatih University, Ankara, Turkey. celiknurullah@hotmail.com
authors.forename: Nurullah
authors.initials: N
authors.lastname: Celik
authors.forename: Nesibe
authors.initials: N
authors.lastname: Andiran
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009765:Obesity / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism*; D010710:Phosphates / Q000032:analysis / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010710:Phosphates