title: The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.
abstract: Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca(2+) that is tapped by the Ca(2+)-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca(2+) release from this acidic Ca(2+) store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family.
authors.affiliation: Department of Cell and Developmental Biology, University College London, London, UK. patel.s@ucl.ac.uk
authors.forename: Sandip
authors.initials: S
authors.lastname: Patel
authors.forename: Latha
authors.initials: L
authors.lastname: Ramakrishnan
authors.forename: Taufiq
authors.initials: T
authors.lastname: Rahman
authors.forename: Amro
authors.initials: A
authors.lastname: Hamdoun
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Marchant
authors.forename: Colin W
authors.initials: CW
authors.lastname: Taylor
authors.forename: Eugen
authors.initials: E
authors.lastname: Brailoiu
mesh_terms: D000143:Acids / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D008247:Lysosomes / Q000378:metabolism*; D009249:NADP / Q000031:analogs & derivatives* / Q000378:metabolism; D024642:Potassium Channels, Voltage-Gated / Q000378:metabolism; D015222:Sodium Channels / Q000378:metabolism; D019831:Sodium-Calcium Exchanger / Q000378:metabolism
chemical_list: D000143:Acids; D015220:Calcium Channels; D024642:Potassium Channels, Voltage-Gated; D015222:Sodium Channels; D019831:Sodium-Calcium Exchanger; D009249:NADP; C024376:NAADP; D002118:Calcium