title: Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells.
abstract: The origin of GnRH-1 cells and olfactory ensheathing cells has been controversial. Genetic Cre-lox lineage tracing of the neural crest (NC) versus ectodermal contribution to the developing nasal placode was performed using two complementary mouse models, the NC-specific Wnt1Cre mouse line and an ectodermal-specific Crect mouse line. Using these lines we prove that the NC give rise to the olfactory ensheathing cells and subpopulations of GnRH-1 neurons, olfactory and vomeronasal cells. These data demonstrate that Schwann cells and olfactory ensheathing cells share a common developmental origin. Furthermore, the results indicate that certain conditions that impact olfaction and sexual development, such as Kallmann syndrome, may be in part neurocristopathies.
authors.affiliation: Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Paolo Emanuele
authors.initials: PE
authors.lastname: Forni
authors.forename: Carol
authors.initials: C
authors.lastname: Taylor-Burds
authors.forename: Vida Senkus
authors.initials: VS
authors.lastname: Melvin
authors.forename: Trevor
authors.initials: T
authors.lastname: Williams
authors.forename: Taylor
authors.initials: T
authors.lastname: Williams
authors.forename: Susan
authors.initials: S
authors.lastname: Wray
mesh_terms: D000818:Animals; D002452:Cell Count; D019070:Cell Lineage / Q000502:physiology*; D004475:Ectoderm / Q000166:cytology* / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D008822:Mice, Transgenic; D009432:Neural Crest / Q000166:cytology* / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D012583:Schwann Cells / Q000166:cytology* / Q000378:metabolism
chemical_list: D007987:Gonadotropin-Releasing Hormone