title: Renal dysfunction in leprosy: a historical cohort of 923 patients in Brazil.
abstract: We investigated the factors associated with renal dysfunction in leprosy patients from Brazil. We report on a historical cohort of leprosy patients followed in two hospitals in Fortaleza City in northeastern Brazil. The factors associated with renal dysfunction were investigated. A total of 923 patients were included, with a mean age of 41.5 ± 19.1 years, and 53.3% were male. Renal dysfunction was found in 35 cases (3.8%). Proteinuria was found in 4.8% of cases, haematuria in 6.8% and leukocyturia in 10.4%. Factors associated with renal dysfunction by multivariate analysis were: reaction episode (odds ratio [OR] = 3.9, P = 0.03), multibacillary classification (OR = 3.5, P = 0.02) and advanced age (OR = 1.04, P = 0.01). Four patients (0.4%) died. Leprosy is associated with renal dysfunction, especially in older patients and those presenting with reaction episode and multibacillary classification.
authors.affiliation: Department of Internal Medicine, School of Medicine, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Ceará, Brazil. ef.daher@uol.com.br
authors.forename: Elizabeth F
authors.initials: EF
authors.lastname: Daher
authors.forename: Geraldo B
authors.initials: GB
authors.lastname: Silva
authors.forename: Lia C
authors.initials: LC
authors.lastname: Cezar
authors.forename: Rafael S A
authors.initials: RS
authors.lastname: Lima
authors.forename: Natacha H
authors.initials: NH
authors.lastname: Gurjão
authors.forename: Rosa M S
authors.initials: RM
authors.lastname: Mota
authors.forename: Krasnalhia Lívia S
authors.initials: KL
authors.lastname: Abreu
authors.forename: Natália A
authors.initials: NA
authors.lastname: Rocha
authors.forename: Michelle J C
authors.initials: MJ
authors.lastname: Oliveira
authors.forename: Alexandre B
authors.initials: AB
authors.lastname: Libório
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006417:Hematuria / Q000150:complications; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D007677:Kidney Function Tests; D056006:Leprosy, Multibacillary / Q000150:complications* / Q000453:epidemiology; D056005:Leprosy, Paucibacillary / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000150:complications; D012307:Risk Factors; D055815:Young Adult