title: Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations.
abstract: OBJECTIVE
  Studies investigating the association between genetic polymorphism of cyclin D1 (CCND1) G870A and risk of colorectal cancer (CRC) reported conflicting results. In order to derive a more precise estimation of the relationship, a meta-analysis was performed.
  
  
  METHODS
  We performed an extensive search of relevant studies and carried out a meta-analysis, including 20 studies with 5,975 cases and 8,333 controls, to obtain a more precise estimate.
  
  
  RESULTS
  Overall, significantly elevated colorectal cancer risk was associated with variant allele 870A when all studies were pooled (AA vs. GG: OR = 1.23, 95% CI = 1.04-1.44; GA vs. GG: OR = 1.13, 95% CI = 1.01-1.26; dominant model: OR = 1.16, 95% CI = 1.03-1.31). In the subgroup analysis by ethnicity, significantly increased risks were detected among Caucasians (AA vs. GG: OR = 1.27, 95% CI = 1.04-1.44; dominant model: OR = 1.17, 95% CI = 1.02-1.34).We also observed sporadic CRC with an increased cancer susceptibility (AA vs. GG: OR = 1.24, 95% CI = 1.04-1.48; dominant model: OR = 1.17, 95% CI = 1.04-1.33), when colorectal cancer was stratified into sporadic CRC and hereditary nonpolyposis colorectal cancer (HNPCC). However, no significant associations were found in both Asians and HNPCC patients for all genetic models.
  
  
  CONCLUSIONS
  Result suggests that the cyclin D1 870A allele is a low-penetrant risk factor for developing sporadic colorectal cancer, especially among Caucasians.
authors.affiliation: Department of Medical Oncology, Affiliated Cancer Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Lou-Qian
authors.initials: LQ
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Jun-Qing
authors.initials: JQ
authors.lastname: Shang
authors.forename: Jian-Ling
authors.initials: JL
authors.lastname: Bai
authors.forename: Fu-Yin
authors.initials: FY
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Guan
authors.forename: Jian-Nong
authors.initials: JN
authors.lastname: Zhou
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1