title: One-day session LINAC-based stereotactic radiosurgery of posterior uveal melanoma.
abstract: OBJECTIVE
  LINAC-based stereotactic radiosurgery (SRS) of posterior uveal melanoma is a conservative method to treat uveal melanoma.
  
  
  METHODS
  This was a retrospective clinic-based study of patients with posterior uveal melanoma in stage T2/T3 who underwent 1-day session SRS at LINAC accelerator or SRS plus combined methods from 2001 to 2008.
  
  
  RESULTS
  Thirty-nine patients with posterior uveal melanoma were treated with SRS (age 25-80 years, median 54 years). Median tumor volume at baseline was 0.6 cm3 (range 0.2-1.3 cm3). The therapeutic dose (TD) was 35.0 Gy, median of maximal dose applied was 49.0 Gy (range 37.0-60.0 Gy). Patient data were analyzed in groups: group 1, single SRS irradiation; group 2, SRS with subsequent endoresection or cyclectomy or additional transpupillary thermotherapy (TTT) or brachytherapy by Ru106 plaques; group 3a, enucleation after single SRS; group 3b, enucleation after SRS and endoresection/cyclectomy or TTT or brachytherapy Ru106. In patients with visual acuity of 20/40 or better, the median rate of best-corrected visual acuity (BCVA) decline was higher than that of the total and significantly higher than the rate of decline in the complementary group of patients with BCVA less than 20/40 (p=0.0077; Mann-Whitney U test).
  
  
  CONCLUSIONS
  One-step LINAC-based SRS with a single dose 35.0 Gy is a method to treat middle-stage posterior uveal melanoma and to preserve the eye globe or as the first step of combined methods: irradiation before endoresection or cyclectomy.
authors.affiliation: Department of Ophthalmology, Medical School, Comenius University, Bratislava, Slovak Republic. alikafurdova@yahoo.com
authors.forename: Alena
authors.initials: A
authors.lastname: Furdova
authors.forename: Peter
authors.initials: P
authors.lastname: Strmen
authors.forename: Iveta
authors.initials: I
authors.lastname: Waczulikova
authors.forename: Martin
authors.initials: M
authors.lastname: Chorvath
authors.forename: Miron
authors.initials: M
authors.lastname: Sramka
authors.forename: Peter
authors.initials: P
authors.lastname: Slezak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009367:Neoplasm Staging; D010315:Particle Accelerators; D016634:Radiosurgery; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000473:pathology / Q000601:surgery*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D012429:Ruthenium Radioisotopes