title: Modified titanium surfaces alter osteogenic differentiation: a comparative microarray-based analysis of human mesenchymal cell response to commercial titanium surfaces.
abstract: The differential effects of dual-acid etched (Osseotite), hydroxyapatite coated (HA) and sand-blasted/acid-etched (SLA) titanium surfaces on human bone marrow-derived mesenchymal cells (hMSCs) were investigated. Proliferation was significantly promoted on the SLA surfaces. 16 genes were significantly upregulated when hMSCs were cultured on the Osseotite and the HA surfaces and 15 genes on the SLA surfaces. Upregulated genes control cell differentiation, signal transduction, cell cycle regulation, angiogenesis, cell adhesion, and extracellular matrix and bone formation.
authors.forename: Anastasios
authors.initials: A
authors.lastname: Mamalis
authors.forename: Spyridon
authors.initials: S
authors.lastname: Silvestros
mesh_terms: D020906:Air Abrasion, Dental; D000704:Analysis of Variance; D001854:Bone Marrow Cells; D002448:Cell Adhesion; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D017886:Durapatite; D005109:Extracellular Matrix / Q000502:physiology; D020869:Gene Expression Profiling; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D020411:Oligonucleotide Array Sequence Analysis; D010006:Osteoblasts / Q000502:physiology; D010012:Osteogenesis / Q000235:genetics*; D012044:Regression Analysis; D013499:Surface Properties; D014025:Titanium
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D017886:Durapatite; D014025:Titanium