title: CYP2E1 Rsa I/Pst I polymorphism contributes to oral cancer susceptibility: a meta-analysis.
abstract: Previous data on association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk were controversial. To investigate the association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk. We performed a meta-analysis to assess the relationship between oral cancer and genotype with English language until June 2010. Twelve published case-control studies of 1259 patients with oral cancer and 2262 controls were acquired. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association in codominant and dominant models. Overall, the pooled ORs indicated a significant association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk (for c1/c2 vs. c1/c1: OR=1.30, 95% CI=1.04-1.62, Pheterogeneity=0.57; for (c1/c2+c2/c2) vs. c1/c1: OR=1.32, 95% CI=1.07-1.64, Pheterogeneity=0.57, respectively). In subgroup analysis by race, the same significant risks were found among Asian (for c1/c2 vs. c1/c1: OR=1.41, 95% CI=1.05-1.91, Pheterogeneity=0.92; for (c1/c2+c2/c2) vs. c1/c1: OR=1.43, 95% CI=1.08-1.88, Pheterogeneity=0.97, respectively). In conclusion, this meta-analysis demonstrates that CYP2E1 Rsa I/Pst I c2 allele may be a biomarker for oral cancer, especially among Asian populations.
authors.affiliation: Institute of Dental Research, School of Stomatology, Nanjing Medical University, 140 Han Zhong Rd, Nanjing, 210029, People's Republic of China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Niu
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Hu
authors.forename: Mingyue
authors.initials: M
authors.lastname: Wu
authors.forename: Fei
authors.initials: F
authors.lastname: Jiang
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
authors.forename: Chunbo
authors.initials: C
authors.lastname: Tang
authors.forename: Ning
authors.initials: N
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016014:Linear Models; D009062:Mouth Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D019392:Cytochrome P-450 CYP2E1