title: Chalcones isolated from Angelica keiskei and their inhibition of IL-6 production in TNF-α-stimulated MG-63 cell.
abstract: Six chalcone compounds, 2',4',4-trihydroxy-3'-[2-hydroxy-7-methyl-3-methylene-6-octaenyl]chalcone (1), 2',4',4-trihydroxy-3'-geranylchalcone (2), 2',4',4-trihydroxy-3'-[6-hydroxy-3,7-dimethyl-2,7-octadienyl]chalcone (3), 2',4-dihydroxy-4'-methoxy-3'-[2-hydroperoxy-3-methyl-3-butenyl]chalcone (4), 2',4-dihydroxy-4'-methoxy-3'-geranylchalcone (5), and 2',4-dihydroxy-4'-methoxy-3'-[3-methyl-3-butenyl]chalcone (6) were isolated from the leaves of Angelica keiskei K (Umbelliferae). The structure of each isolated compound was determined using spectroscopic methods. Among the isolates, compounds 1-3 appeared to have potent inhibitory activity of IL-6 production in TNF-α-stimulated MG-63 cell, while compounds 4-6 did not. The distinct structural difference between compounds 1-3 and 4-6 was the presence of C-4' hydroxyl group in the chalcone moiety. Our results imply that the inhibitory activity of IL-6 production in TNF-α-stimulated MG-63 cell may be affected by the presence of C-4' hydroxyl group in the chalcone moiety.
authors.affiliation: College of Pharmacy, Chosun University, Gwangju, Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Shin
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Choi
authors.forename: Qinglong
authors.initials: Q
authors.lastname: Jin
authors.forename: Hong-Guang
authors.initials: HG
authors.lastname: Jin
authors.forename: Eun-Rhan
authors.initials: ER
authors.lastname: Woo
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D047188:Chalcones / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology; D015394:Molecular Structure; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000494:pharmacology*; D000093242:Interleukin-6 Inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D047188:Chalcones; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors; C508600:IL6 protein, human