title: Association of tumor induced vascularization with clinicopathological parameters in cervical neoplasm.
abstract: Angiogenic properties have been shown in preinvasive cervical lesions. Our goal was to determine the angiogenesis in cervical intraepithelial neoplasms (CIN), the relationship between microvessel counts, histopathological parameters and the clinical outcome in invasive cervical carcinoma. Comparison of microvessel counts from normal epithelium with that from CIN and invasive carcinoma showed significant increases in pre-cancerous lesions and invasive cancer (p < 0.0001). Microvessel density, assessed by CD31 immunostaining, was found to be associated with the overall survival in women with clinical stage IB cervical carcinoma (p < 0.03). There was a significant association of microvessel density (p < 0.05) with relapse-free survival in patients with regional lymph node metastasis.
authors.affiliation: UNIV BASEL,INST PATHOL,CH-4031 BASEL,SWITZERLAND.
authors.forename: A
authors.initials: A
authors.lastname: Dellas
authors.forename: H
authors.initials: H
authors.lastname: Moch
authors.forename: E
authors.initials: E
authors.lastname: Schultheiss
authors.forename: G
authors.initials: G
authors.lastname: Feichter
authors.forename: A
authors.initials: A
authors.lastname: Almendral
authors.forename: F
authors.initials: F
authors.lastname: Gudat
authors.forename: J
authors.initials: J
authors.lastname: Torhorst