title: FurinDB: A database of 20-residue furin cleavage site motifs, substrates and their associated drugs.
abstract: FurinDB (freely available online at http://www.nuolan.net/substrates.html) is a database of furin substrates. This database includes experimentally verified furin cleavage sites, substrates, species, experimental methods, original publications of experiments and associated drugs targeting furin substrates. The current database release contains 126 furin cleavage sites from three species: mammals, bacteria and viruses. A main feature of this database is that all furin cleavage sites are recorded as a 20-residue motif, including one core region (eight amino acids, P6-P2') and two flanking solvent accessible regions (eight amino acids, P7-P14, and four amino acids, P3'-P6'), that represent our current understanding of the molecular biology of furin cleavage. This database is important for understanding the molecular evolution and relationships between sequence motifs, 3D structures, cellular functions and physical properties required by furin for cleavage, and for elucidating the molecular mechanisms and the progression of furin cleavage associated human diseases, including pathogenic infections, neurological disorders, tumorigenesis, tumor invasion, angiogenesis, and metastasis. FurinDB database will be a solid addition to the publicly available infrastructure for scientists in the field of molecular biology.
authors.affiliation: Institute of Biomechanics, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China; E-Mails: huangqqss@163.com (Q.H.); yfang@scut.edu (Y.F.).
authors.forename: Sun
authors.initials: S
authors.lastname: Tian
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Fang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wu
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D001665:Binding Sites; D062126:Databases, Chemical; D030562:Databases, Protein; D045683:Furin / Q000378:metabolism*; D008969:Molecular Sequence Data; D059748:Proteolysis; D013379:Substrate Specificity; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D014764:Viral Proteins; D045683:Furin