title: SCA3 presenting as an isolated axonal polyneuropathy.
abstract: OBJECTIVE
  To highlight an unexpected clinical presentation and to review the associated polyneuropathy phenotypes of SCA3.
  
  
  METHODS
  Clinical follow-up.
  
  
  METHODS
  Neurological referral center.
  
  
  METHODS
  Middle-aged man with no family history for SCA3.
  
  
  RESULTS
  Presentation with an isolated axonal, distal, symmetric, sensorimotor polyneuropathy for 6 years before developing a cerebellar syndrome prompting genetic testing for SCA3.
  
  
  CONCLUSIONS
  SCA3 can present with an isolated axonal, distal, symmetric, sensorimotor polyneuropathy.
authors.affiliation: Neuromuscular Unit, West London Neurosciences Centre, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom.
authors.forename: Tracey D
authors.initials: TD
authors.lastname: Graves
authors.forename: Roberto J
authors.initials: RJ
authors.lastname: Guiloff
mesh_terms: D000067699:Ataxin-3; D001369:Axons / Q000378:metabolism; D003937:Diagnosis, Differential; D015417:Hereditary Sensory and Motor Neuropathy / Q000235:genetics*; D006801:Humans; D017827:Machado-Joseph Disease / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D011115:Polyneuropathies / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics*; D019680:Trinucleotide Repeat Expansion
chemical_list: D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; C092341:ATXN3 protein, human; D000067699:Ataxin-3