title: High CD10 expression in lymph node metastases from surgically treated prostate cancer independently predicts early death.
abstract: Patients with nodal positive prostate cancers are an important cohort with poorly defined risk factors. CD10 is a cell surface metallopeptidase that has been suggested to play a role in prostate cancer progression. CD10 expression was evaluated in 119 nodal positive prostate cancer patients using tissue microarrays constructed from primary tumors and lymph node metastases. All patients underwent radical prostatectomy and standardized extended lymphadenectomy. They had no neoadjuvant therapy and received deferred androgen deprivation. In the primary tumor, high CD10 expression was significantly associated with earlier death from disease when compared with low CD10 expression (5-year survival 73.7% vs. 91.8%; p = 0.043). In the metastases, a high CD10 expression was significantly associated with larger total size of metastases (median 11.4 vs. 6.5 mm; p = 0.015), earlier death of disease (5-year survival 71.5% vs. 87.3%; p = 0.017), and death of any cause (5-year survival 70.0% vs. 87.2%; p = 0.001) when compared with low CD10 expression. CD10 expression in the metastases added independent prognostic information for overall survival (p = 0.029) after adjustment for Gleason score of the primary tumor, nodal tumor burden, and resection margins. In conclusion, a high CD10 expression in prostate cancer predicts early death. This information is inherent in the primary tumors and in the lymph node metastases and might help to personalize patient management.
authors.affiliation: Institute of Pathology, University of Bern, Bern, Switzerland. achim.fleischmann@pathology.unibe.ch
authors.forename: Achim
authors.initials: A
authors.lastname: Fleischmann
authors.forename: Carla
authors.initials: C
authors.lastname: Rocha
authors.forename: Nikolina
authors.initials: N
authors.lastname: Saxer-Sekulic
authors.forename: Inti
authors.initials: I
authors.lastname: Zlobec
authors.forename: Guido
authors.initials: G
authors.lastname: Sauter
authors.forename: George N
authors.initials: GN
authors.lastname: Thalmann
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D015260:Neprilysin