title: Folate-decorated nanogels for targeted therapy of ovarian cancer.
abstract: Nanogels are comprised of swollen polymer networks and nearly 95% water and can entrap diverse chemical and biological agents for cancer therapy with very high loading capacities. Here we use diblock copolymer poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) to form nanogels with the desired degree of cross-linking. The nanogels are further conjugated to folic acid (FA) and loaded with different types of drugs (cisplatin, doxorubicin). For the first time we demonstrate a tumor-specific delivery and superior anti-tumor effect in vivo of an anti-cancer drug using these polyelectrolyte nanogels decorated with folate-targeting groups. This reinforces the use of nanogels for the therapy of ovarian and other cancers, where folate receptor (FR) is overexpressed.
authors.affiliation: Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine College of Pharmacy, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA.
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Nukolova
authors.forename: Hardeep S
authors.initials: HS
authors.lastname: Oberoi
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Cohen
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kabanov
authors.forename: Tatiana K
authors.initials: TK
authors.lastname: Bronich
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001682:Biological Availability; D001835:Body Weight / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D004705:Endocytosis / Q000502:physiology; D005260:Female; D005492:Folic Acid / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D008027:Light; D051379:Mice; D008819:Mice, Nude; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D009994:Osmolar Concentration; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010316:Particle Size; D010984:Platinum / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D012542:Scattering, Radiation; D055672:Static Electricity; D013499:Surface Properties; D016019:Survival Analysis; D014867:Water / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D020100:Hydrogels; D011109:Polymethacrylic Acids; C547781:poly(ethylene oxide)-b-poly(methacrylic acid); D014867:Water; D011092:Polyethylene Glycols; D010984:Platinum; D004317:Doxorubicin; D005492:Folic Acid; D002945:Cisplatin