title: Evaluation of thermal-oxidative stability and antiglioma activity of Zanthoxylum tingoassuiba essential oil entrapped into multi- and unilamellar liposomes.
abstract: Zanthoxylum tinguassuiba essential oil (ZtEO) contains α-bisabolol, a known antiglioma sesquiterpene, among other potentially active substances. Medical applications of this essential oil require advances in the design of distinctive carriers due to its low water solubility and easy degradation by heat, light, and oxygen. The aim of this work was to evaluate enhancement in oxidative stability and the ability to reduce glioblastoma cell viability of ZtEO loaded into liposomes. Multi- and unilamellar vesicles were prepared to carry ZtEO. By using thermal analysis, it was observed that thermal-oxidative stability of the liposomal ZtEO was enhanced, when compared to its free form. Liposomal ZtEO also presented significant apoptotic-inducing activity for glioma cells. These results show that liposomal systems carrying ZtEO may be a potential alternative for gliobastoma treatment.
authors.affiliation: LAPEMM, Faculty of Pharmacy, Federal University of Bahia, Salvador, Brazil. cassia.detoni@gmail.com
authors.forename: Cassia B
authors.initials: CB
authors.lastname: Detoni
authors.forename: Diêgo Madureira
authors.initials: DM
authors.lastname: de Oliveira
authors.forename: Islane E
authors.initials: IE
authors.lastname: Santo
authors.forename: André São
authors.initials: AS
authors.lastname: Pedro
authors.forename: Ramon
authors.initials: R
authors.lastname: El-Bacha
authors.forename: Eudes
authors.initials: E
authors.lastname: da Silva Velozo
authors.forename: Domingos
authors.initials: D
authors.lastname: Ferreira
authors.forename: Bruno
authors.initials: B
authors.lastname: Sarmento
authors.forename: Elaine C
authors.initials: EC
authors.lastname: de Magalhães Cabral-Albuquerque
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004355:Drug Stability; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D008081:Liposomes / Q000737:chemistry*; D015394:Molecular Structure; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010084:Oxidation-Reduction; D035261:Plant Components, Aerial / Q000737:chemistry; D012995:Solubility; D013329:Structure-Activity Relationship; D013696:Temperature; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D008081:Liposomes; D009822:Oils, Volatile