title: Remote intermittent ischemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation?
abstract: Perioperative myocardial ischemia contributes to postoperative morbidity and mortality. Remote intermittent ischemia (RI) has been shown to benefit patients undergoing coronary artery bypass graft (CABG) surgery by decreasing postoperative cardiac troponin levels. In addition, there is evidence that volatile anesthetics may provide myocardial protection. In this prospective randomized controlled trial we tested the hypothesis that RI is cardioprotective under a strict anesthetic regime with volatile anesthesia until cardiopulmonary bypass (CPB). We also assessed whether RI modulates postoperative cytokine and growth factor concentrations. Fifty-four patients referred for elective CABG surgery without concomitant valve or aortic surgery were randomized to three 5-min cycles of left upper limb ischemia by cuff inflation (RI) or placebo without cuff inflation (Plac). All patients received the volatile anesthetic isoflurane (1.15-1.5 vol%) before CPB and the intravenous anesthetic propofol (3-4 mg/kg/h) thereafter until the end of surgery. Cardiac arrest during CPB was induced by intermittent cross-clamp fibrillation, or by blood cardioplegia. We excluded patients older than 85 years, with unstable angina, significant renal disease, and those taking sulfonylureas. Troponin I (cTnI) was measured preoperatively and after 6, 12, 24 and 48 h. In addition, brain natriuretic peptide (BNP), creatine kinase (CKMB) and a panel of cytokines and growth factors were analyzed perioperatively. Although cTnI, BNP and CKMB all increased post-CABG, there were no significant differences between RI and Plac groups; area under the curve for cTnI 189.4 (183.6) ng/mL/48 h and 183.0 (155.2) ng/mL/48 h mean (SD), p = 0.90, respectively, despite a tendency to a shorter (p < 0.07) cross-clamp time in the treatment group. Similarly, there were no differences between groups in the central venous concentrations of numerous cytokines and growth factors. In patients undergoing CABG surgery RI does not provide myocardial protection under a strict anesthetic regime with volatile anesthesia until CPB, and RI was not associated with changes in cytokines.
authors.affiliation: Department of Anaesthetics, Intensive Care Medicine and Pain Therapy, King's College Hospital NHS Foundation Trust, Denmark Hill, London, United Kingdom.
authors.forename: Partheeban
authors.initials: P
authors.lastname: Karuppasamy
authors.forename: Sanjay
authors.initials: S
authors.lastname: Chaubey
authors.forename: Tracy
authors.initials: T
authors.lastname: Dew
authors.forename: Rebecca
authors.initials: R
authors.lastname: Musto
authors.forename: Roy
authors.initials: R
authors.lastname: Sherwood
authors.forename: Jatin
authors.initials: J
authors.lastname: Desai
authors.forename: Lindsay
authors.initials: L
authors.lastname: John
authors.forename: Ajay M
authors.initials: AM
authors.lastname: Shah
authors.forename: Michael S
authors.initials: MS
authors.lastname: Marber
authors.forename: Gudrun
authors.initials: G
authors.lastname: Kunst
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001026:Coronary Artery Bypass; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood
chemical_list: D016207:Cytokines; D019210:Troponin I