title: Copper selenide nanocrystals for photothermal therapy.
abstract: Ligand-stabilized copper selenide (Cu(2-x)Se) nanocrystals, approximately 16 nm in diameter, were synthesized by a colloidal hot injection method and coated with amphiphilic polymer. The nanocrystals readily disperse in water and exhibit strong near-infrared (NIR) optical absorption with a high molar extinction coefficient of 7.7 × 10(7) cm(-1) M(-1) at 980 nm. When excited with 800 nm light, the Cu(2-x)Se nanocrystals produce significant photothermal heating with a photothermal transduction efficiency of 22%, comparable to nanorods and nanoshells of gold (Au). In vitro photothermal heating of Cu(2-x)Se nanocrystals in the presence of human colorectal cancer cell (HCT-116) led to cell destruction after 5 min of laser irradiation at 33 W/cm(2), demonstrating the viabilitiy of Cu(2-x)Se nanocrystals for photothermal therapy applications.
authors.affiliation: Department of Chemical Engineering, Texas Materials Institute, Center for Nano- and Molecular Science and Technology, Austin, Texas 78712, United States.
authors.forename: Colin M
authors.initials: CM
authors.lastname: Hessel
authors.forename: Varun P
authors.initials: VP
authors.lastname: Pattani
authors.forename: Michael
authors.initials: M
authors.lastname: Rasch
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Panthani
authors.forename: Bonil
authors.initials: B
authors.lastname: Koo
authors.forename: James W
authors.initials: JW
authors.lastname: Tunnell
authors.forename: Brian A
authors.initials: BA
authors.lastname: Korgel
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry; D006801:Humans; D007834:Lasers; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D010789:Phototherapy; D012643:Selenium / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D006046:Gold; D003300:Copper; D012643:Selenium