title: A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma.
abstract: We report a case of compassionate use of a haemoglobin-based oxygen carrier in a severely injured Jehovah's Witness patient, for whom survival was considered unlikely. Severe anaemia and cardiac hypoxia were reversed after slow infusion of this agent. No vasoactive side effects were associated with the treatment, possibly due to the slow infusion, and the patient survived.
authors.affiliation: The Alfred, Melbourne, VIC, Australia. m.fitzgerald@alfred.org.au
authors.forename: Mark C
authors.initials: MC
authors.lastname: Fitzgerald
authors.forename: Julie Y
authors.initials: JY
authors.lastname: Chan
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Ross
authors.forename: Susan M
authors.initials: SM
authors.lastname: Liew
authors.forename: Warwick W
authors.initials: WW
authors.lastname: Butt
authors.forename: David
authors.initials: D
authors.lastname: Baguley
authors.forename: Hatem H
authors.initials: HH
authors.lastname: Salem
authors.forename: Matthias K
authors.initials: MK
authors.lastname: Russ
authors.forename: Conor
authors.initials: C
authors.lastname: Deasy
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Martin
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Mathew
authors.forename: Jeffrey V
authors.initials: JV
authors.lastname: Rosenfeld
mesh_terms: D000063:Accidents, Traffic; D000328:Adult; D000740:Anemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D016063:Blood Loss, Surgical / Q000517:prevention & control; D001802:Blood Substitutes / Q000008:administration & dosage*; D001803:Blood Transfusion / Q000941:ethics; D057176:Compassionate Use Trials; D005260:Female; D006454:Hemoglobins / Q000008:administration & dosage*; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D033221:Jehovah's Witnesses; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000209:etiology; D012068:Religion and Medicine; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; C096798:HBOC 201