title: The placental factor in spontaneous preterm labor with and without premature rupture of membranes.
abstract: The association between infection and inflammatory response in preterm labor (PTL) is well established. Our aim was to elucidate the roles of utero-placental perfusion and fetal component, in PTL.
  
  
  
  Histopathologic findings in placentas from pregnancies complicated by preterm birth with or without premature rupture of membranes (ROM) (study group) were compared to placentas from pregnancies with delivery >34 weeks, with or without spontaneous ROM (control group). Placental lesions were classified as those consistent with maternal circulation abnormalities, maternal underperfusion, vascular or villous changes, and those consistent with fetal thrombo-occlusive disease, vascular or villous changes. Lesions were analyzed by maternal or fetal origin of inflammatory response.
  
  
  
  The study group of 68 women, had a higher rate of vascular lesions than controls (136 women, 26.5% vs. 11%, P=0.005) and of inflammatory lesions of maternal and fetal origin (P<0.001). Within the study group, inflammatory lesions were more common in those with ruptured membrane than in those without (P<0.001).
  
  
  
  Placentas from preterm birth demonstrate vascular lesions of maternal origin, in addition to the known inflammatory process. Preterm premature membrane rupture is associated with an increased rate of inflammatory lesions relative to spontaneous intact membranes-preterm birth, suggesting a different underlying mechanism.
authors.affiliation: Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, Holon, Israel. michalkovo@gmail.com
authors.forename: Michal
authors.initials: M
authors.lastname: Kovo
authors.forename: Letizia
authors.initials: L
authors.lastname: Schreiber
authors.forename: Avi
authors.initials: A
authors.lastname: Ben-Haroush
authors.forename: Leena
authors.initials: L
authors.lastname: Asalee
authors.forename: Sarit
authors.initials: S
authors.lastname: Seadia
authors.forename: Abraham
authors.initials: A
authors.lastname: Golan
authors.forename: Jacob
authors.initials: J
authors.lastname: Bar
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002821:Chorioamnionitis / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D007752:Obstetric Labor, Premature / Q000473:pathology / Q000503:physiopathology*; D010920:Placenta / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D011247:Pregnancy; D011256:Pregnancy Outcome