title: Prophylactic antibiotics in orthopaedic surgery.
abstract: The use of prophylactic antibiotics in orthopaedic surgery has been proven effective in reducing surgical site infections after hip and knee arthroplasty, spine procedures, and open reduction and internal fixation of fractures. To maximize the beneficial effect of prophylactic antibiotics, while minimizing any adverse effects, the correct antimicrobial agent must be selected, the drug must be administered just before incision, and the duration of administration should not exceed 24 hours.
authors.affiliation: Sonoran Orthopedic Trauma Surgeons, Scottsdale, AZ, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Prokuski
authors.forename: Terry A
authors.initials: TA
authors.lastname: Clyburn
authors.forename: Richard P
authors.initials: RP
authors.lastname: Evans
authors.forename: Calin S
authors.initials: CS
authors.lastname: Moucha
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D001182:Arthroscopy; D002511:Cephalosporins / Q000008:administration & dosage; D006225:Hand / Q000601:surgery; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D019637:Orthopedic Procedures; D013122:Spinal Diseases / Q000601:surgery; D013203:Staphylococcal Infections / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control; D014640:Vancomycin / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D014640:Vancomycin