title: [Alterations of proteins and lipids glycosylation in pancreatic diseases].
abstract: Proteins and lipids undergo the post- or co-translation modification, which changes their physiochemical and functional properties. The most common modification is glycosylation. The alterations of glycosylation appear following the course of various diseases. The results of these alterations are the structural and functional changes in tissues and organs. The alterations of proteins and lipids glycosylation occur also during the course of pancreatic diseases. These involve glycoconjugates of membranes, as well as glycolipids (gangliosides) located in the cells of the pancreas and in pancreatic islets. The structure of these compounds is dependent on the localization in the organ, and the changes in its structure can be monitored by the determination of carbohydrate levels in the blood. In pancreas diseases the alteration of glycosylation of plasma glycoproteins are also important. Some of them may be a prognostic markers of the disease.
authors.affiliation: Uniwersytet Medyczny w Białymstoku, Zakład Diagnostyki Biochemicznej.
authors.forename: Ewa
authors.initials: E
authors.lastname: Gruszewska
authors.forename: Lech
authors.initials: L
authors.lastname: Chrostek
mesh_terms: D000818:Animals; D006017:Glycolipids / Q000378:metabolism*; D006023:Glycoproteins / Q000097:blood*; D006031:Glycosylation; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism*; D050356:Lipid Metabolism; D010182:Pancreatic Diseases / Q000378:metabolism*
chemical_list: D006017:Glycolipids; D006023:Glycoproteins