title: Isolation of a new natural product and cytotoxic and antimicrobial activities of extracts from fungi of Indonesian marine habitats.
abstract: In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC₅₀ value of 1.5 μg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 μg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.
authors.affiliation: Department of Pharmaceutical Biology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
authors.forename: Kustiariyah
authors.initials: K
authors.lastname: Tarman
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lindequist
authors.forename: Kristian
authors.initials: K
authors.lastname: Wende
authors.forename: Andrea
authors.initials: A
authors.lastname: Porzel
authors.forename: Norbert
authors.initials: N
authors.lastname: Arnold
authors.forename: Ludger A
authors.initials: LA
authors.lastname: Wessjohann
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D003470:Culture Media; D005399:Fishes; D005618:Fresh Water; D005658:Fungi / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D007214:Indonesia; D020128:Inhibitory Concentration 50; D000461:Rhodophyta / Q000382:microbiology; D012623:Seawater; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D003470:Culture Media