title: Are age cutoffs still used to identify candidates for invasive testing for chromosomal abnormalities?
abstract: OBJECTIVE
  Our objective was to determine whether women > or = age 35 are more likely to undergo invasive testing after risk adjustment as compared with younger women at similar adjusted risk.
  
  
  METHODS
  Results of first-trimester combined aneuploidy risk assessment of singleton pregnancies from 2007-2008 were reviewed. For each level of adjusted risk, the rate of invasive testing (CVS or amniocentesis) was compared for those < age 35 and those > or = age 35. Spearman correlation, Fisher's exact test, and chi2 for trend were used for statistical comparison.
  
  
  RESULTS
  For all categories except adjusted risk of 1 in < or = 250, women > or = age 35 were significantly more likely to undergo invasive testing as compared with younger women of similar risk. In women > or = age 35 with low adjusted risk, we observed a trend towards lower rates of invasive testing over time.
  
  
  CONCLUSIONS
  The higher rate of invasive testing in those > or = 35 indicates that women are still being categorized based on age, though our data suggest this may be decreasing.
authors.affiliation: Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York, USA.
authors.forename: Shane W
authors.initials: SW
authors.lastname: Wasden
authors.forename: Brandi N
authors.initials: BN
authors.lastname: Adams
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Chasen
mesh_terms: D000328:Adult; D000649:Amniocentesis / Q000706:statistics & numerical data; D000782:Aneuploidy; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D015193:Chorionic Villi Sampling / Q000706:statistics & numerical data; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D005865:Gestational Age; D006801:Humans; D008423:Maternal Age; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D011296:Prenatal Diagnosis / Q000379:methods* / Q000706:statistics & numerical data*; D012307:Risk Factors
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A