title: Dissociated incretin hormone response to protein versus fat ingestion in obese subjects.
abstract: Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers [body mass index (BMI) >30 kg/m(2) ; n = 12] and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat versus protein. However, the total 300-min GIP response was greater after fat than after protein ingestion (20.3 ± 3.9 vs. 10.0 ± 2.8 nmol/l × min; p = 0.026), whereas the 300-min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300-min GIP secretion is more pronounced after fat than protein ingestion.
authors.affiliation: Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Lindgren
authors.forename: R D
authors.initials: RD
authors.lastname: Carr
authors.forename: J J
authors.initials: JJ
authors.lastname: Holst
authors.forename: C F
authors.initials: CF
authors.lastname: Deacon
authors.forename: B
authors.initials: B
authors.lastname: Ahrén
mesh_terms: D000328:Adult; D004041:Dietary Fats / Q000378:metabolism*; D004044:Dietary Proteins / Q000378:metabolism*; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000096:biosynthesis*; D006801:Humans; D054795:Incretins / Q000378:metabolism*; D008297:Male; D009765:Obesity / Q000378:metabolism*
chemical_list: D004041:Dietary Fats; D004044:Dietary Proteins; D054795:Incretins; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1