title: Protective effects of broadly neutralizing immunoglobulin against homologous and heterologous equine infectious anemia virus infection in horses with severe combined immunodeficiency.
abstract: Using the equine infectious anemia virus (EIAV) lentivirus model system, we previously demonstrated protective effects of broadly neutralizing immune plasma in young horses (foals) with severe combined immunodeficiency (SCID). However, in vivo selection of a neutralization-resistant envelope variant occurred. Here, we determined the protective effects of purified immunoglobulin with more potent broadly neutralizing activity. Overall, protection correlated with the breadth and potency of neutralizing activity in vitro. Four of five SCID foals were completely protected against homologous challenge, while partial protection occurred following heterologous challenge. These results support the inclusion of broadly neutralizing antibodies in lentivirus control strategies.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA.
authors.forename: Sandra D
authors.initials: SD
authors.lastname: Taylor
authors.forename: Steven R
authors.initials: SR
authors.lastname: Leib
authors.forename: Wuwei
authors.initials: W
authors.lastname: Wu
authors.forename: Robert
authors.initials: R
authors.lastname: Nelson
authors.forename: Susan
authors.initials: S
authors.lastname: Carpenter
authors.forename: Robert H
authors.initials: RH
authors.lastname: Mealey
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000008:administration & dosage / Q000276:immunology*; D000914:Antibodies, Viral / Q000008:administration & dosage / Q000276:immunology; D004859:Equine Infectious Anemia / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D006734:Horse Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D006736:Horses; D007136:Immunoglobulins / Q000008:administration & dosage / Q000276:immunology*; D004860:Infectious Anemia Virus, Equine / Q000276:immunology*; D016511:Severe Combined Immunodeficiency / Q000276:immunology / Q000662:veterinary* / Q000821:virology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007136:Immunoglobulins