title: [Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part I].
abstract: Nonsteroidal antiinflammatory drugs (NSAIDs) contain conventional nonselective drugs and selective inhibitors cyclooxygenase-2 (ICOX-2). NSAIDs frequently cause adverse effects tied with cyclooxygenases (COX, COXs) inhibition and prostaglandins (PG, PGs) synthesis, which exerts different physiological effects and are involved in the patophysiology of osteoarthritis. NSAIDs don't inhibit leucotriens (LT LTs) generation. Nonselective drugs cause detrimental results in the gastrointestinal tract. Selective COX-2 inhibitors exert thrombotic cardiovascular events and other negative effects in cardiovascular system. NSAIDs can intensify symptoms of OA and accelerate its progress. Analgetic and antiinflammatory properties possess also licofelone, a competitive inhibitor of cyclooxygenases and 5-lipooxygenase (5-LOX), which presents well gastrointestinal tract tolerability in contrast to NSAIDs. Licofelone decreases the production of proinflammatory leucotrienes and prostaglandins. Moreover inhibition of 5-lipooxygenase activity can delay of cartilago degradation.
authors.affiliation: Uniwersytet Medyczny w Łodzi, Zakład Farmakologii Katedry Farmakologii i Farmakologii Klinicznej. farmakologia@pharma.am.lodz.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Dzielska-Olczak
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D010003:Osteoarthritis / Q000188:drug therapy*; D011758:Pyrroles / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D011758:Pyrroles; C088092:licofelone