title: Differential expression between PAX-6 and EN proteins in medulloblastoma.
abstract: A collection of 28 medulloblastomas was analyzed for expression of the developmental control genes PAX-6 and EN by immunohistochemical staining. Sixteen medulloblastomas expressed both EN and PAX-6 but, when differentiation could be assessed in the positive areas, PAX-6 is expressed in the less differentiated cells. Since Drosophila en encodes a negative regulator, we overexpressed the chicken en-1 in retinal pigmented epithelium cells. This resulted in Pax-6 down regulation. These results suggest a regulatory loop between PAX-6 and EN, two molecular markers of medulloblastoma.
authors.affiliation: CHRU LILLE,DEPT NEUROSURG,F-59037 LILLE,FRANCE. CHRU LILLE,DEPT NEUROPATHOL,F-59037 LILLE,FRANCE. INST PASTEUR,CNRS,EP56,LAB DIFFERENCIAT CELLULAIRE & MOL,F-59019 LILLE,FRANCE.
authors.forename: S
authors.initials: S
authors.lastname: Vincent
authors.forename: N
authors.initials: N
authors.lastname: Turque
authors.forename: S
authors.initials: S
authors.lastname: Plaza
authors.forename: P
authors.initials: P
authors.lastname: Dhellemmes
authors.forename: J
authors.initials: J
authors.lastname: Hladky
authors.forename: R
authors.initials: R
authors.lastname: Assaker
authors.forename: M
authors.initials: M
authors.lastname: Ruchoux
authors.forename: S
authors.initials: S
authors.lastname: Saule