title: [Design, optimization and quality evaluation of curcumin self-emulsifying drug delivery system (SEDDS)].
abstract: OBJECTIVE
  To develop the self-emulsifying drug delivery system (SEDDS) of curcumin, and evaluate its quality in vitro.
  
  
  METHODS
  The excipients of curcumin SEDDS were selected via its solubility study in various oils, surfactants and co-surfactants and the formulation was optimized using ternary phase diagram study and central composite design-response surface methodology (oil, surfactant and co-surfactant percentages as factors; solubility, droplet size, polydispersity index and emulsifying time as responses). The appearance, droplet size and polydispersity index after emulsifying and the emulsifying time of optimized curcumin SEDDS were studied. The solubility of curcumin in the solution of SEDDS was determined.
  
  
  RESULTS
  Castor oil-(tween-80) -ethanol = 28: 55: 20 (w/ w/w) was selected for optimum curcumin SEDDS. The droplet size was 222. 2 nm, polydispersity index was 0. 171. The time of self-emulsifying was 10 s and the solubility of curcumin in SEDDS was 1.93 mg/mL.
  
  
  CONCLUSIONS
  Curcumin SEDDS formulation is selected and optimized successfully, and the preparation of curcumin SEDDS is simple, the quality is stable.
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu 611731, China. wyhxxsc312@yahoo.cn
authors.forename: Yun-Hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Sheng-Hua
authors.initials: SH
authors.lastname: Wang
authors.forename: Rong-Ping
authors.initials: RP
authors.lastname: Yang
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Ma
mesh_terms: D002368:Castor Oil / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D000431:Ethanol / Q000008:administration & dosage / Q000737:chemistry; D010316:Particle Size; D011136:Polysorbates / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D013997:Time Factors
chemical_list: D004655:Emulsions; D011136:Polysorbates; D013501:Surface-Active Agents; D000431:Ethanol; D002368:Castor Oil; D003474:Curcumin