title: In vitro Differentiation Potential of Mesenchymal Stem Cells.
abstract: SUMMARY: Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.
authors.affiliation: Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Gimble
authors.forename: Farshid
authors.initials: F
authors.lastname: Guilak
authors.forename: Mark E
authors.initials: ME
authors.lastname: Nuttall
authors.forename: Solomon
authors.initials: S
authors.lastname: Sathishkumar
authors.forename: Martin
authors.initials: M
authors.lastname: Vidal
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Bunnell