title: Enantiomeric segregation in the gel phase of lipid bilayers.
abstract: Enantiospecific interactions within a monoglyceride lipid bilayer are investigated using molecular dynamics simulations. Preferential homochiral interactions are observed in the gel phase, whereas no detectable enantiospecificity is seen in the liquid-crystal phase. On the basis of these results and available experimental data, a mechanism is proposed for the formation of the coagel phase of monoglycerides. Enantiomeric segregation in the gel phase is also discussed in terms of its possible implications for prebiological evolution and membrane raft function.
authors.affiliation: Laboratory of Physical Chemistry, Swiss Federal Institute of Technology, ETH-Hönggerberg, 8093 Zürich, Switzerland. bruno.horta@igc.phys.chem.ethz.ch
authors.forename: Bruno A C
authors.initials: BA
authors.lastname: Horta
authors.forename: Philippe H
authors.initials: PH
authors.lastname: Hünenberger
mesh_terms: D005782:Gels / Q000737:chemistry*; D006860:Hydrogen Bonding; D008051:Lipid Bilayers / Q000737:chemistry*; D050866:Liquid Crystals / Q000737:chemistry*; D008954:Models, Biological; D015394:Molecular Structure; D044367:Phase Transition; D013237:Stereoisomerism
chemical_list: D005782:Gels; D008051:Lipid Bilayers