title: A case of relapsing polychondritis associated with auricular cartilage infiltration of immunoglobulin G4-positive plasma cells and lung cancer.
abstract: A 79-year-old man was diagnosed with relapsing polychondritis, from symptoms of bilateral auricular deformity and pigmentation, polyarthralgia, and audiovestibular damage, and from histological examination of the left auricular cartilage. The left auricular cartilage biopsy specimen revealed cartilage destruction with infiltration of plasmacytes expressing IgG4. This case suggests that IgG4 may be involved in the pathogenesis and etiology of relapsing polychondritis.
authors.affiliation: Department of Internal Medicine and Rheumatology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan. yoshirohorai0518@qmed.hosp.go.jp
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Horai
authors.forename: Tomoya
authors.initials: T
authors.lastname: Miyamura
authors.forename: Hokuto
authors.initials: H
authors.lastname: Arase
authors.forename: Daisaku
authors.initials: D
authors.lastname: Kimura
authors.forename: Karin
authors.initials: K
authors.lastname: Shimada
authors.forename: Motoko
authors.initials: M
authors.lastname: Ishida
authors.forename: Soichiro
authors.initials: S
authors.lastname: Takahama
authors.forename: Junichi
authors.initials: J
authors.lastname: Kiyasu
authors.forename: Rumi
authors.initials: R
authors.lastname: Minami
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Eiichi
authors.initials: E
authors.lastname: Suematsu
authors.forename: Yoshifuku
authors.initials: Y
authors.lastname: Nakayama
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000000981:diagnostic imaging; D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology* / Q000473:pathology; D001706:Biopsy; D004431:Ear, External / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology; D011081:Polychondritis, Relapsing / Q000150:complications / Q000276:immunology* / Q000473:pathology; D011859:Radiography
chemical_list: D007074:Immunoglobulin G