title: Plasticity of human menstrual blood stem cells derived from the endometrium.
abstract: Stem cells can be obtained from women's menstrual blood derived from the endometrium. The cells display stem cell markers such as Oct-4, SSEA-4, Nanog, and c-kit (CD117), and have the potent ability to differentiate into various cell types, including the heart, nerve, bone, cartilage, and fat. There has been no evidence of teratoma, ectopic formation, or any immune response after transplantation into an animal model. These cells quickly regenerate after menstruation and secrete many growth factors to display recurrent angiogenesis. The plasticity and safety of the acquired cells have been demonstrated in many studies. Menstrual blood-derived stem cells (MenSCs) provide an alternative source of adult stem cells for research and application in regenerative medicine. Here we summarize the multipotent properties and the plasticities of MenSCs and other endometrial stem cells from recent studies conducted both in vitro and in vivo.
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Lin
authors.forename: Dennis
authors.initials: D
authors.lastname: Xiang
authors.forename: Jin-long
authors.initials: JL
authors.lastname: Zhang
authors.forename: Julie
authors.initials: J
authors.lastname: Allickson
authors.forename: Charlie
authors.initials: C
authors.lastname: Xiang
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D004717:Endometrium / Q000166:cytology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007511:Ischemia / Q000628:therapy; D008598:Menstruation / Q000097:blood*; D039902:Multipotent Stem Cells / Q000166:cytology / Q000378:metabolism; D024510:Muscle Development; D020388:Muscular Dystrophy, Duchenne / Q000628:therapy; D009203:Myocardial Infarction / Q000628:therapy; D009422:Nervous System Diseases / Q000628:therapy; D055495:Neurogenesis; D010179:Pancreas / Q000166:cytology
chemical_list: D015415:Biomarkers