title: [Relationship between cholecystokinin gene -45C/T polymorphism and schizophrenia and its application in forensic medicine].
abstract: OBJECTIVE
  To investigate the polymorphism of cholecystokinin (CCK) gene -45C/T of schizophrenia and its application in forensic medicine.
  
  
  METHODS
  Bidirectional allele specific PCR was used to detect CCK gene -45C/T polymorphisms in 207 schizophrenic patients (case group) and 202 healthy individuals (control group) of the Han population in northern China. The chi2 test was used to identify Hardy-Weinberg equilibrium of the genotype distribution in control group. The differences of genotype and allele frequencies distributions were compared between two groups.
  
  
  RESULTS
  Distributions of the genotype frequencies satisfied the law of Hardy-Weinberg equilibrium in control group. The differences between genotypic frequencies and allele frequencies were not statistical significance in case group and control groups (P > 0.05). Gender-stratified analysis showed that frequency of allele T in female case group was statistically higher than that in female control group (P = 0.044).
  
  
  CONCLUSIONS
  CCK gene -45C/T locus T allele may be positively associated with schizophrenia in female population and useful in schizophrenia identification.
authors.affiliation: School of Forensic Medicine, China Medical University, Shenyang 110001, China. yangliu03170015@163.com
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Mei
authors.initials: M
authors.lastname: Ding
authors.forename: Yin
authors.initials: Y
authors.lastname: Sun
authors.forename: Hao
authors.initials: H
authors.lastname: Pang
authors.forename: Jia-xin
authors.initials: JX
authors.lastname: Xing
authors.forename: Jin-feng
authors.initials: JF
authors.lastname: Xuan
authors.forename: Chun-mei
authors.initials: CM
authors.lastname: Li
authors.forename: Bao-jie
authors.initials: BJ
authors.lastname: Wang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D002766:Cholecystokinin / Q000235:genetics*; D005260:Female; D053803:Forensic Genetics; D005555:Forensic Psychiatry; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D002766:Cholecystokinin