title: Post-exercise changes in myostatin and actRIIB expression in obese insulin-resistant rats.
abstract: We evaluated the expression of MSTN and ActRIIB mRNA in muscle and adipose tissue in diet-induced obesity and insulin resistance in rats subjected to exercise. There was no difference in the expression of MSTN between exercised and sedentary high-fat fed rats in muscle after swimming training. The expression of ActRIIB mRNA in muscle was not significantly different among the groups. In BAT, MSTN mRNA expression was higher in exercised high-fat fed group (EHF) compared with sedentary high-fat fed group (SHF). ActRIIB mRNA expression in BAT was higher in EHF compared with SHF. In mesenteric fat, MSTN mRNA was lower in EHF compared with SHF and ActRIIB mRNA was lower in EHF compared with SHF. In conclusion, the results demonstrate that the expression of MSTN and ActRIIB mRNA changes in both adipose tissue and skeletal muscle in diet-induced obese and exercised rats and suggest the participation of MSTN in energy homeostasis.
authors.affiliation: Department of Physiology, University of São Carlos, São Carlos, SP, Brazil.
authors.forename: P G
authors.initials: PG
authors.lastname: Bueno
authors.forename: D
authors.initials: D
authors.lastname: Bassi
authors.forename: D G
authors.initials: DG
authors.lastname: Contrera
authors.forename: H M
authors.initials: HM
authors.lastname: Carnielli
authors.forename: R N
authors.initials: RN
authors.lastname: Silva
authors.forename: K O
authors.initials: KO
authors.lastname: Nonaka
authors.forename: H S
authors.initials: HS
authors.lastname: Selistre-de-Araújo
authors.forename: A M O
authors.initials: AM
authors.lastname: Leal
mesh_terms: D030301:Activin Receptors, Type II / Q000235:genetics / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000378:metabolism; D050154:Adiposity; D000818:Animals; D019540:Area Under Curve; D001835:Body Weight; D004041:Dietary Fats; D004822:Epididymis / Q000473:pathology; D015870:Gene Expression; D005951:Glucose Tolerance Test; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology; D018482:Muscle, Skeletal / Q000378:metabolism; D055435:Myostatin / Q000235:genetics / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004041:Dietary Fats; C525913:Mstn protein, rat; D055435:Myostatin; D030301:Activin Receptors, Type II; C425584:activin receptor type II-B