title: Recombination mapping of the susceptibility region for sporadic inclusion body myositis within the major histocompatibility complex.
abstract: Susceptibility to sporadic inclusion body myositis (sIBM) in Caucasians has been consistently associated with alleles of the major histocompatibility complex (MHC) 8.1 ancestral haplotype (AH) (defined by HLA-B*0801 and HLA-DRB1*0301). In this study recombination mapping was utilised to further refine the known 8.1AH susceptibility region near HLA-DRB1*0301. Caucasian sIBM patients carrying part of the 8.1AH were genotyped for a selection of 8.1AH-haplotypic polymorphisms. A common 8.1AH-specific susceptibility region was defined, spanning 172 kb and encompassing three genes--HLA-DRB3, HLA-DRA and BTNL2. It is thus likely that 8.1AH-derived susceptibility to sIBM originates from at least one of these genes.
authors.affiliation: School of Pathology and Laboratory Medicine, M504, University of Western Australia, Perth, Australia. ascott@cyllene.uwa.edu.au
authors.forename: Adrian P
authors.initials: AP
authors.lastname: Scott
authors.forename: Nigel G
authors.initials: NG
authors.lastname: Laing
authors.forename: Frank
authors.initials: F
authors.lastname: Mastaglia
authors.forename: Merrilee
authors.initials: M
authors.lastname: Needham
authors.forename: Maggie C
authors.initials: MC
authors.lastname: Walter
authors.forename: Marinos C
authors.initials: MC
authors.lastname: Dalakas
authors.forename: Richard J N
authors.initials: RJ
authors.lastname: Allcock
mesh_terms: D000483:Alleles; D002460:Cell Line; D002874:Chromosome Mapping / Q000379:methods*; D015331:Cohort Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D018979:Myositis, Inclusion Body / Q000453:epidemiology / Q000235:genetics*; D011995:Recombination, Genetic / Q000276:immunology*
chemical_list: D005819:Genetic Markers