title: Age-specific effects of early MK-801 treatment on working memory in female rats.
abstract: The N-methyl-D-aspartate receptor plays a crucial role in developmental plasticity. Evidence shows that neonatal exposure to N-methyl-D-aspartate receptor antagonists impairs cognition in adult rats. This study investigated whether neonatal MK-801 treatment would produce long-term and age-specific effects on working memory and sensorimotor gating in adolescent and adult female rats. After treatment with MK-801 at postnatal days (PND) 5-14, female rats exhibited slightly impaired working memory during adolescence (PND: 35-42). In contrast, working memory was remarkably disrupted in adult (PND: 63-70) female rats. However, prepulse inhibition and startle amplitudes were not significantly affected at both ages. These findings indicate that neonatal MK-801 elicits working memory deficits, especially in the postpuberty female rats.
authors.affiliation: Key Laboratory of Mental Health of National Health Ministry, Institute of Mental Health, Peking University, Beijing, China.
authors.forename: Yun-Ai
authors.initials: YA
authors.lastname: Su
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Wang
authors.forename: Ji-Tao
authors.initials: JT
authors.lastname: Li
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Guo
authors.forename: Yu
authors.initials: Y
authors.lastname: Feng
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Run-Hu
authors.initials: RH
authors.lastname: Huang
authors.forename: Tian-Mei
authors.initials: TM
authors.lastname: Si
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D018782:Maze Learning / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D013216:Reflex, Startle / Q000187:drug effects
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate