title: Active thionium species mediated functionalization at the 2α-position of indole derivatives.
abstract: A combination of dimethyl sulfoxide (DMSO) and trifluoroacetic anhydride (TFAA) mediates functionalization at the 2α-position of indole derivatives. Carbon and heteroatom nucleophiles were directly introduced via a one-pot procedure in excellent yields.
authors.affiliation: Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Higuchi
authors.forename: Masanori
authors.initials: M
authors.lastname: Tayu
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kawasaki
mesh_terms: D000089:Acetic Anhydrides; D002244:Carbon / Q000737:chemistry; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D005463:Fluoroacetates; D007211:Indoles / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D014269:Trifluoroacetic Acid / Q000737:chemistry
chemical_list: D000089:Acetic Anhydrides; D005463:Fluoroacetates; D007211:Indoles; D000644:Quaternary Ammonium Compounds; C017958:trifluoroacetic anhydride; D002244:Carbon; C059915:thionium; C030374:indole; D014269:Trifluoroacetic Acid; D004121:Dimethyl Sulfoxide