title: Molecular cytogenetic analysis of a gliosarcoma with osseous metaplasia.
abstract: Gliosarcoma, a rare glioblastoma variant, is composed of a glial and a mesenchymal component. Though the mesenchymal portion most commonly resembles a fibrosarcoma, other differentiation patterns have been observed. We present the first genomic characterisation (karyotyping followed by FISH and array comparative genomic hybridisation analysis) of a gliosarcoma with osseous metaplasia. In addition to chromosomal changes often found in gliomas (+7, -10, -13, and -22), the tumour cells also harboured a hitherto unknown t(3;21)(q13∼21;q21∼22).
authors.affiliation: Section for Cancer Cytogenetics, Institute for Medical Informatics, Oslo, Norway. h.s.s.dahlback@medisin.uio.no
authors.forename: H S S
authors.initials: HS
authors.lastname: Dahlback
authors.forename: L
authors.initials: L
authors.lastname: Gorunova
authors.forename: F
authors.initials: F
authors.lastname: Micci
authors.forename: D
authors.initials: D
authors.lastname: Scheie
authors.forename: P
authors.initials: P
authors.lastname: Brandal
authors.forename: T R
authors.initials: TR
authors.lastname: Meling
authors.forename: S
authors.initials: S
authors.lastname: Heim
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology*; D002877:Chromosomes, Human; D055028:Comparative Genomic Hybridization; D018316:Gliosarcoma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D020547:Lateral Ventricles / Q000473:pathology*; D008297:Male; D008679:Metaplasia / Q000235:genetics