title: Efficacy of a single dose of an otic ivermectin preparation or selamectin for the treatment of Otodectes cynotis infestation in naturally infected cats.
abstract: Otodectes cynotis infestation is common in kittens housed in crowded environments like animal shelters. It is unknown how rapidly O cynotis is killed within the first 72h of treatment with currently available products. Kittens ≥4 weeks of age with live O cynotis in both ears (AU) were administered 0.5ml of 0.01% ivermectin otic suspension (Acarexx; Idexx Pharmaceuticals) once, AU or selamectin (Revolution; Pfizer Animal Health) once, on the skin following the manufacturer's instructions. Repeat microscopic examination was performed on individual ears based on a randomization schedule during the 72h after treatment. There was no evidence of toxicity with either drug and administration of 0.01% ivermectin significantly reduced the time to live mite-free status compared to selamectin. Both drugs have an effect against O cynotis as early as 10-12h after administration with an increasing effect over time.
authors.affiliation: Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Nunn-Brooks
authors.forename: Robin
authors.initials: R
authors.lastname: Michael
authors.forename: Lea B
authors.initials: LB
authors.lastname: Ravitz
authors.forename: Dorsey
authors.initials: D
authors.lastname: Kordick
authors.forename: Michael R
authors.initials: MR
authors.lastname: Lappin
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage*; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology*; D002415:Cats; D004423:Ear / Q000469:parasitology; D007559:Ivermectin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin; C414354:selamectin