title: Nonfunctioning pancreatic endocrine tumor with extension into the main pancreatic duct: report of a case.
abstract: Pancreatic endocrine tumors (PETs) rarely involve the main pancreatic duct. We report a case of malignant nonfunctioning pancreatic endocrine tumor (NFPET) with prevalent intraductal growth. A 47-year-old woman was referred to us after ultrasonography at a routine health check showed diffuse swelling of the pancreas. Preoperative imaging showed a solid mass in the tail of the pancreas and a bulging intraductal mass in the main pancreatic duct. We performed total pancreatectomy because the tumor occupied almost the entire lumen of the main pancreatic duct. Histological examination confirmed well-differentiated endocrine carcinoma. We review reported cases of the intraductal growth of NFPETs and discuss the pathogenesis of these unusual tumors.
authors.affiliation: Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Yazawa
authors.forename: Toshihide
authors.initials: T
authors.lastname: Imaizumi
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Okada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Matsuyama
authors.forename: Shoichi
authors.initials: S
authors.lastname: Dowaki
authors.forename: Kosuke
authors.initials: K
authors.lastname: Tobita
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohtani
authors.forename: Kyoji
authors.initials: K
authors.lastname: Ogoshi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Makuuchi
mesh_terms: D018273:Carcinoma, Islet Cell / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D002760:Cholangiopancreatography, Endoscopic Retrograde; D019160:Endosonography; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010180:Pancreatectomy; D010183:Pancreatic Ducts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed