title: Efficient copper-catalyzed synthesis of poly-N-heterocycles containing amino acid residues.
abstract: An efficient copper-catalyzed method has been developed for the synthesis of poly-N-heterocycles containing amino acid residues. The protocol uses readily available 2-halobenzamides containing amino acids and their methyl esters, substituted phenylacetonitriles, and malononitrile as the starting materials and the reactions were performed well under mild conditions. The method should provide a novel and useful strategy for synthesis of N-heterocyclic compounds.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, P R China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Ruji
authors.initials: R
authors.lastname: Wang
authors.forename: Haijun
authors.initials: H
authors.lastname: Yang
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D006571:Heterocyclic Compounds; D006827:Hydantoins; D006846:Hydrocarbons, Halogenated; D015363:Quinolones; D003300:Copper