title: Phenotypic characterization of androgen receptor-related proliferation in prostatic-carcinoma derived cell-cultures.
abstract: Our study reviews the central role of androgens for the development of androgen-insensitive growth in prostatic carcinoma using an individual dynamic model which emulates aspects of proliferation control. Our aim is the identification of individually proliferating cells from prostate carcinoma. Short-term cultured cells (n=205) from radical prostatectomy specimens have been used as the major method to skew the correspondence between the androgen-receptor (AR), proliferation-markers (Ki-67, PCNA) and morphological landmarks (nucleoli, AgNOR). These techniques allowed the identification of distinct androgen-insensitive, proliferating cell-clusters and in the future will allow the analysis of genotypic changes in identified proliferating cell clones.
authors.affiliation: UNIV SAARLAND,DEPT HUMAN GENET,D-66421 HOMBURG,GERMANY.
authors.forename: T
authors.initials: T
authors.lastname: Zwergel
authors.forename: U
authors.initials: U
authors.lastname: Burk
authors.forename: S
authors.initials: S
authors.lastname: Herter
authors.forename: T
authors.initials: T
authors.lastname: Lindenmeir
authors.forename: B
authors.initials: B
authors.lastname: Wullich
authors.forename: G
authors.initials: G
authors.lastname: Unteregger