title: Frequent gains and losses of specific chromosome segments in human ovarian carcinomas shown by comparative genomic hybridization.
abstract: Total genomic DNA obtained from 24 ovarian carcinomas was examined for genomic imbalances by comparative genomic hybridization (CGH). A varying number of gains and losses (1 up to 31) of specific chromosomal segments was detected per tumor. Chromosomal segments which were most often present in increased copy numbers were (in decreasing order): 1q21, 8q24, 8q23, 3q26, 12p12-p13, 20q, 7q31, and 7q33-qter. Loss of material was found most frequently at 16q12, 13q13-q14, Xq, 8p21-p22, 5q13-q14, and 5q21. All these chromosomal segments involved in gains and losses may carry gene loci playing a more or less causal role in the process of ovarian malignancies. Based on these findings CGH can be regarded as a valuable tool for rapid screening of genomic imbalances in human tumors.
authors.affiliation: UNIV ERLANGEN NURNBERG,INST HUMAN GENET,D-90154 ERLANGEN,GERMANY. UNIV ERLANGEN NURNBERG,GYNECOL CLIN,D-90154 ERLANGEN,GERMANY. CITY HOSP,GYNECOL CLIN 1,D-90419 NURNBERG,GERMANY.
authors.forename: E
authors.initials: E
authors.lastname: Wolff
authors.forename: T
authors.initials: T
authors.lastname: Liehr
authors.forename: U
authors.initials: U
authors.lastname: Vorderwulbecke
authors.forename: A
authors.initials: A
authors.lastname: Tulusan
authors.forename: E
authors.initials: E
authors.lastname: Husslein
authors.forename: E
authors.initials: E
authors.lastname: Gebhart