title: Myocardial extraction of intracellular magnesium and atrial fibrillation after coronary surgery.
abstract: BACKGROUND
  The effects of magnesium loading on the incidence of atrial fibrillation following coronary artery bypass graft surgery (CAGB) are equivocal. None of the previous studies assessed the influence of myocardial extraction of magnesium in these settings. The current trial aims to elucidate whether the incidence of atrial fibrillation following CABG is affected by the preoperative rate of myocardial extraction of magnesium.
  
  
  METHODS
  The ethical committee approved the study protocol. 113 patients (94 male, mean age 63 ± 11 years) planned for elective CABG surgery under normothermic cardiopulmonary bypass were prospectively included. Preoperative independent variables included preoperative treatment, electrocardiographic abnormalities, left ventricular ejection fraction estimation, left atrial size, creatinine clearance and assays of plasma and intracellular magnesium, calcium, albumin, potassium and ionized calcium, drawn preoperatively from the coronary sinus and the aortic root. The covariates - including the rate of myocardial extraction of magnesium - were entered in a logistic regression model to predict the odds of atrial fibrillation.
  
  
  RESULTS
  The incidence of post operative atrial fibrillation was 16%. A rate of myocardial extraction of intracellular magnesium ≥ 7% increases fivefold the multivariate risk of postoperative atrial fibrillation (p < .01). Advanced age was also significantly associated to postoperative atrial fibrillation.
  
  
  CONCLUSIONS
  This study suggests that a preoperative rate of myocardial extraction of intracellular magnesium ≥ 7% could be a new and a potent predictive factor for postoperative atrial fibrillation.
authors.affiliation: Department of Cardiology, Hotel-Dieu de France Hospital, Achrafieh, Beirut, Lebanon.
authors.forename: Tony E
authors.initials: TE
authors.lastname: Abdel-Massih
authors.forename: Antoine
authors.initials: A
authors.lastname: Sarkis
authors.forename: Ghassan
authors.initials: G
authors.lastname: Sleilaty
authors.forename: Issam
authors.initials: I
authors.lastname: El Rassi
authors.forename: Chucralla
authors.initials: C
authors.lastname: Chamandi
authors.forename: Nicole
authors.initials: N
authors.lastname: Karam
authors.forename: Fadia
authors.initials: F
authors.lastname: Haddad
authors.forename: Alexandre
authors.initials: A
authors.lastname: Yazigi
authors.forename: Samia
authors.initials: S
authors.lastname: Madi-Jebara
authors.forename: Patricia
authors.initials: P
authors.lastname: Yazbeck
authors.forename: Bechara
authors.initials: B
authors.lastname: El Asmar
authors.forename: Ramzi
authors.initials: R
authors.lastname: Ashoush
authors.forename: Victor
authors.initials: V
authors.lastname: Jebara
mesh_terms: D001281:Atrial Fibrillation / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism*; D001026:Coronary Artery Bypass / Q000009:adverse effects; D005260:Female; D006801:Humans; D042541:Intracellular Space; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011446:Prospective Studies
chemical_list: D008274:Magnesium