title: Arginine extravasation leading to skin necrosis.
abstract: Arginine hydrochloride is used in the evaluation of short stature and in the management of urea cycle disorders. In recent times, it has been used in the treatment of stroke-like episodes of MELAS (mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes). We want to highlight the need for good intravenous access and monitoring the drip site to prevent extravasation injuries that can be caused by arginine, which is a hyperosmolar solution.
authors.affiliation: Department of Paediatrics, Hervey Bay Hospital, Queensland, Australia. maryabraham03@yahoo.co.in
authors.forename: Mary B
authors.initials: MB
authors.lastname: Abraham
authors.forename: Jasper
authors.initials: J
authors.lastname: van der Westhuyzen
authors.forename: Vikrant
authors.initials: V
authors.lastname: Khanna
mesh_terms: D000140:Acidosis, Lactic / Q000188:drug therapy; D001120:Arginine / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D005119:Extravasation of Diagnostic and Therapeutic Materials; D006801:Humans; D008297:Male; D017237:Mitochondrial Encephalomyopathies / Q000188:drug therapy; D009336:Necrosis / Q000139:chemically induced*; D017063:Outcome Assessment, Health Care; D011793:Queensland; D012640:Seizures / Q000188:drug therapy; D012867:Skin / Q000503:physiopathology*
chemical_list: D001120:Arginine