title: The Ross operation in children and young adults: a fifteen-year, single-institution experience.
abstract: BACKGROUND
  The optimal operation for aortic valve disease in children and young adults remains controversial. The Ross operation offers avoidance of anticoagulation and the potential for growth but is technically demanding and creates double-valve disease. The goal of this study is to report our experience with the Ross operation and the need for reintervention at intermediate follow-up.
  
  
  METHODS
  A retrospective review of Ross operations in a single surgeon experience from 1992 to 2007 was conducted. All echocardiograms were reevaluated by a single cardiologist.
  
  
  RESULTS
  The cohort included 54 patients with a mean age of 13.5 years (range 0.5 to 35 years). Pulmonary autograft implantation was accomplished using root replacement (n=43), root inclusion (n=9), and Dacron tube root replacement (n=2). Follow-up was available for 47 patients (87%) at a mean length of 6.4 years. There were no deaths. Kaplan-Meier estimates of freedom from explantation at 10 years were 100% for the autograft and 71% for the homograft. Autograft insufficiency at latest follow-up was trivial in 37 patients (82%), mild in 6 patients (13%), and moderate in 2 patients (4%). Reintervention for the homograft included balloon dilation in 3 children and conduit change in 5 children (all≤2 years old at initial operation).
  
  
  CONCLUSIONS
  The Ross operation can be performed in children and adults with low mortality and can provide a durable result for the aortic valve with a low incidence of aortic insufficiency. The need for homograft replacement during follow-up in our series was primarily limited to children who were age 2 years or younger at initial operation.
authors.affiliation: Department of Pediatrics, Penn State Hershey, Hershey, Pennsylvania 17033, USA. jclark7@hmc.psu.edu
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Clark
authors.forename: Linda B
authors.initials: LB
authors.lastname: Pauliks
authors.forename: Ashley
authors.initials: A
authors.lastname: Rogerson
authors.forename: Allen R
authors.initials: AR
authors.lastname: Kunselman
authors.forename: John L
authors.initials: JL
authors.lastname: Myers
mesh_terms: D000293:Adolescent; D000328:Adult; D001021:Aortic Valve / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011664:Pulmonary Valve / Q000637:transplantation*; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D055815:Young Adult