title: Getting personal with prostate cancer: adding new pieces to an incomplete jigsaw puzzle.
abstract: Prostate cancer is a multifaceted molecular anomaly that is insurmountable to date because of the orchestrated network of negative regulators that drive carcinogenesis. A substantial fraction of information has been added that gives yet an unclear snapshot of therapeutic interventions in prostate cancer. Increasing sophisticated interpretations point towards some important aspects of prostate cancer aggressiveness like microRNAs, prostate cancer stem cells and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) refractoriness. In this review, we will evaluate the push and pull between oncomirs and tumor suppressors in tipping the scales of cancer. Furthermore, multicomponent rational drug designs with a claim to overcome stumbling blocks will be discussed. Translation of the outcomes achieved in the understanding of carcinogenesis at the patient's bedside is possibly the principal challenge in cancer research.
authors.affiliation: Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan. ammadahmad638 @ yahoo.com
authors.forename: Ammad A
authors.initials: AA
authors.lastname: Farooqi
authors.forename: Shahzad
authors.initials: S
authors.lastname: Bhatti
mesh_terms: D017209:Apoptosis; D015972:Gene Expression Regulation, Neoplastic; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000379:methods; D035683:MicroRNAs / Q000378:metabolism; D008954:Models, Biological; D008957:Models, Genetic; D014411:Neoplastic Stem Cells / Q000166:cytology; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D011944:Receptors, Androgen / Q000378:metabolism; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D011944:Receptors, Androgen; D053221:TNF-Related Apoptosis-Inducing Ligand