title: Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents.
abstract: This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53%), ethanol/HCl (75%), ibuprofen (52 %) and ischemia/reperfusion (43 %). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective activity of the extract.
authors.affiliation: Center for Research on Medicinal Plants, Federal University of Piauí, Teresina, PI, Brazil.
authors.forename: Katharinne I Moraes
authors.initials: KI
authors.lastname: de Carvalho
authors.forename: Hélio B
authors.initials: HB
authors.lastname: Fernandes
authors.forename: Flávia D Frota
authors.initials: FD
authors.lastname: Machado
authors.forename: Irisdalva S
authors.initials: IS
authors.lastname: Oliveira
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Oliveira
authors.forename: Paulo Humberto M
authors.initials: PH
authors.lastname: Nunes
authors.forename: Julianeli T
authors.initials: JT
authors.lastname: Lima
authors.forename: Jackson R G Silva
authors.initials: JR
authors.lastname: Almeida
authors.forename: Rita C Meneses
authors.initials: RC
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D031229:Bromeliaceae / Q000737:chemistry* / Q000145:classification; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol; D007213:Indomethacin