title: Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities.
abstract: Two new dibenzocyclooctadiene lignans, rubrilignans A and B (1, 2), together with 17 known ones, were isolated from the fruits of Schisandra rubriflora. The structures of 1 and 2 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also evaluated for their anti-HIV-1 activities and showed weak anti-HIV-1 activity with EC(50) values of 2.26 and 1.82 μg/ml, and therapeutic index values of 35.5 and 18.6, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China.
authors.forename: Huai-Xue
authors.initials: HX
authors.lastname: Mu
authors.forename: Xue-Sen
authors.initials: XS
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Fan
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Yang
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Hu
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D015497:HIV-1 / Q000187:drug effects*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032141:Schisandra / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D017705:Lignans; C559324:rubrilignan A; C559325:rubrilignan B