title: Cyclooxygenase-2 gene expression in human breast cancer.
abstract: Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p<0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.
authors.affiliation: OHIO STATE UNIV,DEPT MED MICROBIOL & IMMUNOL,COLL MED,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,DEPT PATHOL,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,SCH PUBL HLTH,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,CTR COMPREHENS CANC,COLUMBUS,OH 43210.
authors.forename: M
authors.initials: M
authors.lastname: Parrett
authors.forename: R
authors.initials: R
authors.lastname: Harris
authors.forename: F
authors.initials: F
authors.lastname: Joarder
authors.forename: M
authors.initials: M
authors.lastname: Ross
authors.forename: K
authors.initials: K
authors.lastname: Clausen
authors.forename: F
authors.initials: F
authors.lastname: Robertson