title: Laboratory signs of aspirin response in haemodialysis patients.
abstract: BACKGROUND
  Aspirin is effective in the secondary prevention and high-risk primary prevention of cardiovascular events. However, clinical and laboratory evidence demonstrates diminished or no response to aspirin in some patients. This study was designed to assess aspirin response in haemodialysis patients.
  
  
  METHODS
  We prospectively enrolled 78 haemodialysis patients (28 female; 58.4 ± 12.6 years old) and 79 patients (29 female; 58.4 ± 10.6 years old) with normal renal function (glomerular filtration rate (GFR) >60 mL/min/1.73 m(2)). All subjects in both the haemodialysis patient group and the control group were taking aspirin (80-300 mg) for at least 30 days and were not taking other antiplatelet agents. Platelet function was assessed by arachidonic acid-induced aggregometry with a Multiplate analyser (Dynabyte Medical, Munich, Germany). Multiplate electrode aggregometry values below 300 AU were applied as a cut-off for response to aspirin.
  
  
  RESULTS
  Aspirin non-response was two-fold more prevalent in haemodialysis patients (42.3%) than in patients with normal renal function (21.5%), and this difference was statistically significant (p = 0.005). The two groups were similar in terms of sex, age, tobacco use, the presence of diabetes mellitus, and platelet count.
  
  
  CONCLUSIONS
  The frequency of aspirin non-response as defined in this study was higher in haemodialysis patients than in patients with normal renal function. However, larger subsets of patients are needed to confirm the present study.
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Turkey. kadriye11@yahoo.com
authors.forename: Kadriye O
authors.initials: KO
authors.lastname: Kilickesmez
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Kocas
authors.forename: Baris
authors.initials: B
authors.lastname: Okcun
authors.forename: Okay
authors.initials: O
authors.lastname: Abaci
authors.forename: Aysem
authors.initials: A
authors.lastname: Kaya
authors.forename: Alev
authors.initials: A
authors.lastname: Arat
authors.forename: Bilal
authors.initials: B
authors.lastname: Gorcin
authors.forename: Tevfik
authors.initials: T
authors.lastname: Gurmen
mesh_terms: D000368:Aged; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006435:Renal Dialysis; D017211:Treatment Failure
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin