title: Cutaneous silica granuloma with generalized involvement of lymph nodes.
abstract: We report a case of cutaneous silica granuloma with generalized involvement of distal lymph nodes; no similar case has been reported in the published work. The 45-year-old man was a stonemason who had been incidentally sprayed with rock dust from a saw 22 years ago. The subject presented with nodules and erythematous areas on his face and chin. In addition, there was swelling in the cervical and inguinal lymph nodes. An excised lymph node had normal architecture with numerous non-caseating epithelioid cell granuloma and silicotic nodules which contained scattered, multinucleated, giant cells. There were particles in the granuloma exhibiting birefringence under polarized light microscopy. Elemental X-ray spectra of these lesions showed the presence of silica in these granulomas.
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, China.
authors.forename: Maihua
authors.initials: M
authors.lastname: Hou
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Zhu
authors.forename: Yuda
authors.initials: Y
authors.lastname: Ye
mesh_terms: D003460:Crystallization; D005549:Foreign-Body Reaction / Q000378:metabolism / Q000473:pathology; D006099:Granuloma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000378:metabolism / Q000473:pathology; D012822:Silicon Dioxide / Q000737:chemistry / Q000378:metabolism*; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology*; D056928:X-Ray Absorption Spectroscopy
chemical_list: D012822:Silicon Dioxide