title: Overuse of training increases mechanoreceptors in supraspinatus tendon of rats SHR.
abstract: The presence of mechanoreceptors in tendon after overuse activities can be a further step to learn about tendinopathy and overuse. Studies of tendons mechanoreceptors in rats are rare. We studied 12 isogenic spontaneous hypertensive rats (SHR), which underwent an overuse protocol consisting of an hour per daily session of treadmill running at a speed of 17 m/min, 5 times/week for 4 months. Supraspinatus tendons were evaluated with immunohistochemistry using S100 protein antibodies and histological protocol. Supraspinatus tendons at the end of 4 months of overuse protocol had a high number of media mechanoreceptors (4.3) than controls (0.6). The overexpression of S100 protein antibody in overuse activities maybe could represent a adaptative effort to tendon before the tear.
authors.affiliation: Federal University of São Paulo, UNIFESP, São Paulo, Brazil. apochini@uol.com.br
authors.forename: Alberto
authors.initials: A
authors.lastname: de Castro Pochini
authors.forename: Benno
authors.initials: B
authors.lastname: Ejnisman
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: de Seixas Alves
authors.forename: Luiz Fernando
authors.initials: LF
authors.lastname: Uyeda
authors.forename: Viviane Louise Andree
authors.initials: VL
authors.lastname: Nouailhetas
authors.forename: Sang W
authors.initials: SW
authors.lastname: Han
authors.forename: Moises
authors.initials: M
authors.lastname: Cohen
authors.forename: Walter Manna
authors.initials: WM
authors.lastname: Albertoni
mesh_terms: D000818:Animals; D012090:Cumulative Trauma Disorders / Q000503:physiopathology*; D004195:Disease Models, Animal; D008465:Mechanoreceptors / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000009:adverse effects* / Q000502:physiology*; D011434:Proprioception / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D017006:Rotator Cuff / Q000294:innervation / Q000378:metabolism / Q000502:physiology*; D009418:S100 Proteins / Q000378:metabolism; D012785:Shoulder Joint / Q000502:physiology
chemical_list: D009418:S100 Proteins