title: History of immunotherapy: the first 100 years.
abstract: Allergen-specific immunotherapy (SIT) defines and distinguishes the modern practice of clinical allergy and immunology as the 100th anniversary of this pioneering technique is celebrated. Despite the tremendous advancements made in therapeutics, pharmacology, and the basic science of allergy, SIT remains the only treatment modality that offers a potential cure for atopic diseases rather than simply an amelioration of symptoms. A historical perspective not only offers an opportunity to tell some of the fascinating stories that led to the conception of SIT but also gives an occasion to recognize, remember, and honor those individuals who have contributed to its development.
authors.affiliation: Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida College of Medicine, 12908 USF Health Drive, Tampa, FL 33612, USA. dfitzhug@health.usf.edu
authors.forename: David J
authors.initials: DJ
authors.lastname: Fitzhugh
authors.forename: Richard F
authors.initials: RF
authors.lastname: Lockey
mesh_terms: D000485:Allergens / Q000276:immunology / Q000627:therapeutic use*; D003888:Desensitization, Immunologic / Q000266:history*; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*
chemical_list: D000485:Allergens