title: Serum cardiac troponin I in dogs with primary immune-mediated haemolytic anaemia.
abstract: OBJECTIVE
  The assessment of serum cardiac troponin I concentrations in dogs with a range of nonprimary cardiac illnesses has revealed that cardiac myocyte damage is commonplace in many canine diseases. Whilst it is well established that dogs with fatal immune-mediated haemolytic anaemia frequently have cardiac pathology based on post-mortem examinations, there is limited information on the incidence of cardiac myocyte damage in this population of dogs.
  
  
  METHODS
  Serum cardiac troponin I concentrations were measured in 11 healthy dogs, 27 dogs with primary haemolytic anaemia and 49 hospitalised dogs without primary cardiac or haematological disorders.
  
  
  RESULTS
  Dogs with primary haemolytic anaemia have higher serum concentrations of cardiac troponin I than hospitalised ill dogs (P<0.005) and healthy dogs (P<0.01). Using a cut-off of less than 0.1 ng/mL, 20 of 27 dogs with primary haemolytic anaemia had increased serum cardiac troponin I concentrations, which was a significantly higher proportion compared to the hospitalised ill dogs (P<0.001, 16 out of 49 dogs) and healthy dogs (P<0.05, 3 out of 11 dogs).
  
  
  CONCLUSIONS
  Dogs with primary haemolytic anaemia have a higher incidence of subclinical myocyte damage than healthy dogs or dogs with non-haematological or primary cardiac illnesses. The prognostic significance of increased serum cardiac troponin I concentrations in dogs with primary haemolytic anaemia merits further investigation.
authors.affiliation: Royal (Dick) School of Veterinary Studies, The Roslin Institute, Division of Veterinary Clinical Studies, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian.
authors.forename: D J
authors.initials: DJ
authors.lastname: Gow
authors.forename: A G
authors.initials: AG
authors.lastname: Gow
authors.forename: R
authors.initials: R
authors.lastname: Bell
authors.forename: D
authors.initials: D
authors.lastname: Spratt
authors.forename: R
authors.initials: R
authors.lastname: Cash
authors.forename: S
authors.initials: S
authors.lastname: Ricketts
authors.forename: J
authors.initials: J
authors.lastname: Archer
authors.forename: R J
authors.initials: RJ
authors.lastname: Mellanby
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000662:veterinary*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood* / Q000276:immunology; D004285:Dogs; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000662:veterinary*; D008297:Male; D012307:Risk Factors; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I