title: Over 500 pancreas transplants by a single team in São Paulo, Brazil.
abstract: Pancreas transplantation (PT) remains a developing practice in Latin America. From 1996 to 2009, 506 PTs were performed by our team in the following categories: simultaneous pancreas-kidney (SPK), simultaneous deceased donor pancreas and living-donor kidney (SPLK), pancreas after kidney (PAK), and pancreas transplant alone (PTA). Enteric drainage was preferred for SPK and bladder drainage for solitary PT or SPLK. Immunosuppression was with tacrolimus, mycophenolate mofetil, and steroids, and anti-lymphocytic drugs were used to induce solitary PT and SPLK. The series includes 254 SPK, 60 SPLK, 94 PAK, and 98 PTA. The one-yr patient survivals were 82% for SPK, 90% for SPLK, 95% for PTA, and 93% for PAK. The one-yr pancreas graft survivals were 70% for SPK, 86% for SPLK, 86% for PAK, and 77% for PTA. The one-yr kidney graft survivals were 77.5% for SPK and 89% for SPLK. This represents the largest reported PT series in Latin America. Results comparable to those of developed countries were achieved, with the exception of the SPK category. This has led our program to prioritize solitary PT and SPLK.
authors.affiliation: HEPATO (Hepatology and Organ Transplantation), Beneficencia Portuguesa, Albert Einstein, Oswaldo Cruz, São Camilo Hospitals, São Paulo, SP, Brazil. marcelo-perosa@uol.com.br
authors.forename: Marcelo
authors.initials: M
authors.lastname: Perosa
authors.forename: Fabio
authors.initials: F
authors.lastname: Crescentini
authors.forename: Huda
authors.initials: H
authors.lastname: Noujaim
authors.forename: Leonardo T
authors.initials: LT
authors.lastname: Mota
authors.forename: Juan Rafael
authors.initials: JR
authors.lastname: Branez
authors.forename: Luiz Estevam
authors.initials: LE
authors.lastname: Ianhez
authors.forename: Gustavo
authors.initials: G
authors.lastname: Ferreira
authors.forename: Rodrigo Azevedo
authors.initials: RA
authors.lastname: de Oliveira
authors.forename: Tércio
authors.initials: T
authors.lastname: Genzini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil; D002648:Child; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000628:therapy*; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D011183:Postoperative Complications; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult