title: A QTL for genotype by sex interaction for anthropometric measurements in Alaskan Eskimos (GOCADAN Study) on chromosome 19q12-13.
abstract: Variation in anthropometric measurements due to sexual dimorphism can be the result of genotype by sex interactions (G×S). The purpose of this study was to examine the sex-specific genetic architecture in anthropometric measurements in Alaskan Eskimos from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Maximum likelihood-based variance components decomposition methods, implemented in SOLAR, were used for G×S analyses. Anthropometric measurements included BMI, waist circumference (WC), waist/height ratio, percent body fat (%BF), and subscapular and triceps skinfolds. Except for WC, mean values of all phenotypes were significantly different in men and women (P < 0.05). All anthropometric measures were significantly heritable (P < 0.001). In a preliminary analysis not allowing for G×S interaction, evidence of linkage was detected between markers D19S414 and D19S220 on chromosome 19 for WC (logarithm of odds (lod) = 3.5), %BF (lod = 1.7), BMI (lod = 2.4), waist/height ratio (lod = 2.5), subscapular (lod = 2.1), and triceps skinfolds (lod = 1.9). In subsequent analyses which allowed for G×S interaction, linkage was again found between these traits and the same two markers on chromosome 19 with significantly improved lod scores for: WC (lod = 4.5), %BF (lod = 3.8), BMI (lod = 3.5), waist/height ratio (lod = 3.2), subscapular (lod = 3.0), and triceps skinfolds (lod = 2.9). These results support the evidence of a G×S interaction in the expression of genetic effects resulting in sexual dimorphism in anthropometric phenotypes and identify the chromosome 19q12-13 region as important for adiposity-related traits in Alaskan Eskimos.
authors.affiliation: Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA. saroja@sfbrgenetics.org
authors.forename: V Saroja
authors.initials: VS
authors.lastname: Voruganti
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Diego
authors.forename: Karin
authors.initials: K
authors.lastname: Haack
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Cole
authors.forename: John
authors.initials: J
authors.lastname: Blangero
authors.forename: Harald H H
authors.initials: HH
authors.lastname: Göring
authors.forename: Sandra
authors.initials: S
authors.lastname: Laston
authors.forename: Charlotte R
authors.initials: CR
authors.lastname: Wenger
authors.forename: Sven O E
authors.initials: SO
authors.lastname: Ebbesson
authors.forename: Richard R
authors.initials: RR
authors.lastname: Fabsitz
authors.forename: Richard B
authors.initials: RB
authors.lastname: Devereux
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.forename: Jason G
authors.initials: JG
authors.lastname: Umans
authors.forename: Jean W
authors.initials: JW
authors.lastname: MacCluer
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Comuzzie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000413:Alaska; D001837:Body Weights and Measures; D002318:Cardiovascular Diseases / Q000235:genetics / Q000473:pathology; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D004930:Inuit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000235:genetics / Q000473:pathology; D040641:Quantitative Trait Loci; D012727:Sex Characteristics; D055815:Young Adult