title: [New adamantane derivatives and ways of overcoming the resistance of influenza A viruses to rimantadine and amantadine].
abstract: The amino acid and peptide derivatives of 1-adamantane carboxylic acid and rimantadine (18 compounds) have been first synthesized and investigated for their activity against influenza A virus (H1N1, H1N1v). In a series of obtained adamantine derivatives, some compounds have been found to be able to inhibit rimantadine-resistant influenza A virus strains. Thus, the antiviral properties of rimantadine can be restored.
authors.forename: V A
authors.initials: VA
authors.lastname: Shibnev
authors.forename: T M
authors.initials: TM
authors.lastname: Garayev
authors.forename: M P
authors.initials: MP
authors.lastname: Finogenova
authors.forename: E S
authors.initials: ES
authors.lastname: Shevchenko
authors.forename: E I
authors.initials: EI
authors.lastname: Burtseva
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D000547:Amantadine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000187:drug effects*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D007251:Influenza, Human / Q000188:drug therapy*; D012299:Rimantadine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D012299:Rimantadine; C012698:adamantanecarboxylic acid; D000547:Amantadine; D000218:Adamantane