title: [Mechanical ventilation in patients with most severe forms of influenza A H1N1].
abstract: OBJECTIVE
  Pandemic of A H1N1 influenza is noted for its rapid spreading and life-threatening consequences like acute respiratory distress syndrome (ARDS) which requires mechanical ventilation (MV) and intensive therapy (IT).The aim of the study was to determine the significance of mechanical ventilation application in the presence of comorbidities on the outcome of the disease and patients with severe forms of acute influenza caused by A H1N1 virus.
  
  
  METHODS
  Five patients with acute respiratory failure caused by A H1N1 influenza that required MV were included in the study. Course and outcome of the treatment were monitored in relation to age and sex of the patients, concomitant diseases, time of influenza beginning, a time of admittance in an intensive care unit, a time of an endotracheal intubation and MV beginning, MV duration and occurrence of secondary infections.
  
  
  RESULTS
  Three patients were on a very prolonged MV (39, 43 and 20 days, respectively) and they all survived. Two patients with a significantly shorter duration of MV (14 and 12 days, respectively) died because of a very severe clinical course and concomitant diseases. Unexpectedly, we found a positive correlation between duration of MV and survival although two patients, who were on MV for the longest period of time (43 and 39 days, respectively), developed, as a complication, secondary bacterial pneumonia.
  
  
  CONCLUSIONS
  Intensive therapy of patients with ARDS due to A H1N1 influenza virus requires MV which should be carried out according to guidelines of international expert forums. That is in accordance with our unexpected observation on negative correlation between duration of MV and fatal outcome. Intensive treatment of these patients, specially MV, can be very prolonged and, therefore, requires specialized teams of anesthesiologists, separate, isolated intensive therapy units and high level of medical staff protection, as was the case in this study, so no member of medical staff was infected.
authors.affiliation: Vojnomedicinska akademija, Klinika za anesteziologiju i intenzivnu terapiju, Beograd, Srbija.
authors.forename: Predrag
authors.initials: P
authors.lastname: Romić
authors.forename: Darko
authors.initials: D
authors.lastname: Nozić
authors.forename: Maja
authors.initials: M
authors.lastname: Surbatović
authors.forename: Milić
authors.initials: M
authors.lastname: Veljović
authors.forename: Mihajlo
authors.initials: M
authors.lastname: Stojić
authors.forename: Rade
authors.initials: R
authors.lastname: Vuković
mesh_terms: D000208:Acute Disease; D000328:Adult; D003422:Critical Care; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications* / Q000401:mortality / Q000821:virology; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*