title: Clinical significance of integrin alpha 6 mRNA expression in gastric carcinoma.
abstract: Integrin alpha 6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin alpha 6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumors. Concerning the variant, there was a significant correlation between the expression ratio of variant B/variant A and the depth of tumor invasion. In conclusion, i) integrin alpha 6 expression was intimately correlated with histologic differentiation, and ii) the overexpression of variant B may be correlated with tumor invasion of gastric carcinoma.
authors.affiliation: KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,BUNYOU,OITA,JAPAN. UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV DIGEST DIS & NUTR,WORCESTER,MA.
authors.forename: K
authors.initials: K
authors.lastname: Mimori
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: N
authors.initials: N
authors.lastname: Begum
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Haraguchi
authors.forename: H
authors.initials: H
authors.lastname: Ueo
authors.forename: N
authors.initials: N
authors.lastname: Karimine
authors.forename: T
authors.initials: T
authors.lastname: Akiyoshi
authors.forename: G
authors.initials: G
authors.lastname: Barnard