title: GC-MS determined distribution of urinary equol producers as affected by age, gender, and repeated ingestions of soymilk.
abstract: Status of equol excretion is likely a reflection of incidence risk of sex-hormone related diseases and deserves research attention. In this study, urine samples collected from 182 volunteers after soymilk ingestion were subjected to equol quantification using GC-MS. As categorized into male, female, and both genders and each category further classified into 6 age (year) categories, namely, <20, 21 to 30, 31 to 40, 41 to 50, >51 and overall, a trend indicating that the younger age the higher equol producer ratio was observed. For the >51 subjects, the corresponding producer ratios of males and females were 35.3% and 50.0%, respectively. Among the volunteers, 20 nonproducers were further recruited to ingest 1000 mL soymilk weekly for 16 wk and urines were analyzed bi-weekly. As resulted, 8 of 20 nonproducers were induced to become equol producers. The observed change of nonproducers to equol producers induced by repeating ingestions of soymilk is of merit from the viewpoint of healthcare.
authors.affiliation: Dept. of Food Science, Natl. Chiayi Univ., Chiayi 60004, Taiwan.
authors.forename: Ting-Fu
authors.initials: TF
authors.lastname: Ko
authors.forename: Hui-Su
authors.initials: HS
authors.lastname: Tsai
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Lin
authors.forename: Chi-Dong
authors.initials: CD
authors.lastname: Liu
authors.forename: Show-Phon
authors.initials: SP
authors.lastname: Learn
authors.forename: Robin Y Y
authors.initials: RY
authors.lastname: Chiou
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004435:Eating; D060754:Equol; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D007529:Isoflavones / Q000652:urine*; D008297:Male; D008875:Middle Aged; D048789:Phytoestrogens / Q000652:urine*; D012737:Sex Factors; D041942:Soy Milk / Q000008:administration & dosage* / Q000737:chemistry*; D055815:Young Adult
chemical_list: C007610:4',7-dihydroxy-3,4-dihydroisoflavone; D007529:Isoflavones; D048789:Phytoestrogens; D060754:Equol