title: Apolipoprotein B is highly associated with the risk of coronary heart disease as estimated by the Framingham risk score in healthy Korean men.
abstract: The aim of this study was to examine the association between serum apolipoprotein B (apoB) and the risk of coronary heart disease (CHD) using Framingham risk score (FRS) in healthy Korean men. A total of 13,523 men without medication history of diabetes and hypertension were enrolled in this study. The FRS is based on six coronary risk factors. FRS ≥ 10% was defined as more-than-a-moderate risk group and FRS ≥ 20% as high risk group, respectively. The logistic regression analyses were conducted. When quartile 1 (Q1) set as a reference, in unadjusted analyses, the Q2, Q3, Q4 of apoB level had increased odds ratio (OR) for the risk of CHD in both more-than-a-moderate risk and high risk group, respectively. After adjusting for confounding variables, multivariable-adjusted logistic regression analyses showed a strong relationship between the quartiles of apoB level and more-than-a-moderate risk and high risk group, respectively. These associations were attenuated, but still remained statistically significant. ApoB is found to be independently related to the risk of CHD using FRS in healthy Korean men, and the link between apoB and the risk of CHD is dose-dependent.
authors.affiliation: Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Ryoo
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Ha
authors.forename: Soo-Geun
authors.initials: SG
authors.lastname: Kim
authors.forename: Seungho
authors.initials: S
authors.lastname: Ryu
authors.forename: Da-Woon
authors.initials: DW
authors.lastname: Lee
mesh_terms: D000328:Adult; D001055:Apolipoproteins B / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D054526:Men's Health; D008875:Middle Aged; D016017:Odds Ratio; D056910:Republic of Korea; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D001055:Apolipoproteins B