title: Escherichia coli isolates causing bacteremia via gut translocation and urinary tract infection in young infants exhibit different virulence genotypes.
abstract: Escherichia coli bacteremia in young infants may arise via either urinary tract infection or gut translocation (GT). E. coli GT isolates have rarely been investigated. Molecular analysis of 100 E. coli isolates recovered from bacteremic infants revealed that GT isolates had multilocus sequence types similar to those of urosepsis isolates but different prevalences of PapGII adhesin, TcpC protectin, and ibeA invasin. Compared with late-onset GT isolates, early-onset isolates were associated with significantly different rates of the conserved virulence plasmidic region common to human and avian pathogenic strains and α-hemolysin. We identified genetic determinants potentially involved in specific pathophysiological steps preceding E. coli bloodstream invasion.
authors.affiliation: Service de Microbiologie and Laboratoire Associé au Centre National de Référence de Escherichia coli, Paris, France.
authors.forename: Farah
authors.initials: F
authors.lastname: Mahjoub-Messai
authors.forename: Philippe
authors.initials: P
authors.lastname: Bidet
authors.forename: Valérie
authors.initials: V
authors.lastname: Caro
authors.forename: Laure
authors.initials: L
authors.lastname: Diancourt
authors.forename: Valérie
authors.initials: V
authors.lastname: Biran
authors.forename: Yannick
authors.initials: Y
authors.lastname: Aujard
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bonacorsi
mesh_terms: D018830:Adhesins, Escherichia coli / Q000235:genetics; D016470:Bacteremia / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D004926:Escherichia coli / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000235:genetics; D005243:Feces / Q000382:microbiology; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D058885:Multilocus Sequence Typing; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D014552:Urinary Tract Infections / Q000150:complications / Q000382:microbiology*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D018830:Adhesins, Escherichia coli; C096350:CusC protein, E coli; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; C519334:PapGII protein, E coli; C549538:TcpC protein, E coli; D037521:Virulence Factors