title: Role of cell-death ligand-receptor system of granulosa cells in selective follicular atresia in porcine ovary.
abstract: In the mammalian ovary, more than 99% of follicles degenerate without ovulation and few oocytes ovulate and succeed to the next generation. Granulosa cell apoptosis plays a critical role in this process, follicular atresia. However, the molecular mechanisms responsible for the regulation of granulosa cell apoptosis have not been clarified. Death ligand and receptor systems are major apoptosis-inducing factors. This review describes the granulosa cell apoptosis via death ligand and receptor systems during follicular atresia in the porcine ovary.
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. ninoue@agr.nagoya-u.ac.jp
authors.forename: Naoko
authors.initials: N
authors.lastname: Inoue
authors.forename: Fuko
authors.initials: F
authors.lastname: Matsuda
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Goto
authors.forename: Noboru
authors.initials: N
authors.lastname: Manabe
mesh_terms: D000818:Animals; D017209:Apoptosis; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism*; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D013552:Swine; D048069:Tumor Necrosis Factors / Q000378:metabolism*
chemical_list: D018124:Receptors, Tumor Necrosis Factor; D048069:Tumor Necrosis Factors