title: The effects of delivery route and anesthesia type on early postnatal weight loss in newborns: the role of vasoactive hormones.
abstract: OBJECTIVE
  To investigate the effects of delivery route and maternal anesthesia type and the roles of vasoactive hormones on early postnatal weight loss in term newborns.
  
  
  METHODS
  Ninety-four term infants delivered vaginally (group 1, n=31), cesarean section (C/S) with general anesthesia (GA) (group 2, n=29), and C/S with epidural anesthesia (EA) (group 3, n=34) were included in this study. All infants were weighed at birth and on the second day of life and intravenous (IV) fluid infused to the mothers for the last 6 h prior to delivery was recorded. Serum electrolytes, osmolality, N-terminal proANP (NT-proANP), brain natriuretic peptide (BNP), aldosterone and plasma antidiuretic hormone (ADH) concentrations were measured at cord blood and on the second day of life.
  
  
  RESULTS
  Our research showed that postnatal weight loss of infants was higher in C/S than vaginal deliveries (5.7% vs. 1.3%) (p < 0.0001) and in EA group than GA group (6.8% vs. 4.3%) (p < 0.0001). Postnatal weight losses were correlated with IV fluid volume infused to the mothers for the last 6 h prior to delivery (R = 0.814, p = 0.000) and with serum NT-proANP (R = 0.418, p = 0.000), BNP (R = 0.454, p = 0.000), and ADH (R = 0.509, p = 0.000) but not with aldosterone concentrations (p > 0.05).
  
  
  CONCLUSIONS
  Large amounts of IV fluid given to the mothers who were applied EA prior to the delivery affect their offsprings' postnatal weight loss via certain vasoactive hormones.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Ankara, Turkey.
authors.forename: Nurullah
authors.initials: N
authors.lastname: Okumus
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Atalay
authors.forename: Eray E
authors.initials: EE
authors.lastname: Onal
authors.forename: Canan
authors.initials: C
authors.lastname: Turkyilmaz
authors.forename: Saliha
authors.initials: S
authors.lastname: Senel
authors.forename: Berrin
authors.initials: B
authors.lastname: Gunaydin
authors.forename: Hatice
authors.initials: H
authors.lastname: Pasaoglu
authors.forename: Esin
authors.initials: E
authors.lastname: Koc
authors.forename: Ebru
authors.initials: E
authors.lastname: Ergenekon
authors.forename: Suna
authors.initials: S
authors.lastname: Unal
mesh_terms: D000773:Anesthesia, Obstetrical / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D000777:Anesthetics / Q000009:adverse effects / Q000494:pharmacology; D009320:Atrial Natriuretic Factor / Q000494:pharmacology / Q000502:physiology; D001724:Birth Weight / Q000187:drug effects / Q000502:physiology; D002657:Child Development / Q000187:drug effects / Q000502:physiology; D036861:Delivery, Obstetric / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000254:growth & development*; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000494:pharmacology / Q000502:physiology; D036361:Peptide Hormones / Q000494:pharmacology / Q000502:physiology*; D011247:Pregnancy; D047929:Term Birth / Q000502:physiology; D015431:Weight Loss / Q000502:physiology*
chemical_list: D000777:Anesthetics; D036361:Peptide Hormones; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor