title: Phototherapy reduces serum resistin levels in psoriasis patients.
abstract: This study investigated phototherapy-induced changes in certain adipokine levels in patients with psoriasis. Patients with psoriasis (n=36) were recruited and body mass index (BMI) and disease severity (Psoriasis Area and Severity Index) were recorded. Serum resistin and leptin levels before and after bath-psoralen and ultraviolet (UV) A or narrow-band UVB therapy were examined by enzyme-linked immunosorbent assay. Serum leptin levels correlated positively with BMI. Phototherapy induced no remarkable change in the leptin levels, but significantly decreased serum resistin levels from 9.02±8.83 to 4.86±3.30ng/ml. Serum resistin levels might be involved in insulin resistance and inflammation, and correlate with disease severity in patients with psoriasis. The reduction in serum resistin induced by phototherapy might be related to the clinical efficacy of this treatment for psoriasis.
authors.affiliation: Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Kawashima
authors.forename: Kan
authors.initials: K
authors.lastname: Torii
authors.forename: Takuya
authors.initials: T
authors.lastname: Furuhashi
authors.forename: Chiyo
authors.initials: C
authors.lastname: Saito
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nishio
authors.forename: Emi
authors.initials: E
authors.lastname: Nishida
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Shintani
authors.forename: Akimichi
authors.initials: A
authors.lastname: Morita
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000188:drug therapy; D011701:PUVA Therapy; D011565:Psoriasis / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D052243:Resistin / Q000097:blood*; D012307:Risk Factors
chemical_list: C499624:RETN protein, human; D052243:Resistin