title: Viral gene mutation as determinant of low grade malignancy of lesions induced by perinatal retrovirus infection.
abstract: Of 108 Wistar/Ma rats perinatally injected with Snyder-Theilen feline sarcoma virus, 75 developed tumors within 60 days (group A), and 25 after more than 117 days (group B). Metastases were detected in 59.1% and 11.8% in group A and B respectively. Antibody to v-fes gene product was found to occur before tumor development in group B and after tumor development in group A. v-Ses was found to be down-regulated and extensively mutated in tumors of group B. These results suggest viral gene mutation as a determinant of low grade malignancy of lesions induced.
authors.affiliation: CHIBA CANC CTR RES INST,DIV PATHOL,CHUO KU,CHIBA 260,JAPAN.
authors.forename: S
authors.initials: S
authors.lastname: Lu
authors.forename: M
authors.initials: M
authors.lastname: Miyauchi
authors.forename: K
authors.initials: K
authors.lastname: Maruyama