title: Orthopedic implant of a polyhydroxybutyrate (PHB) and hydroxyapatite composite in cats.
abstract: The purpose of this study was to evaluate the tissue response to a 70% polyhydroxybutyrate and 30% hydroxyapatite composite in the form of a bone implant, placed intracortically in the distal metaphyseal of the right femur, and subcutaneous implants in cats. Samples of the composite were implanted subcutaneously in the dorsolumbar region and the distal metaphyseal region of the right femur of the animals. The study used 12 neutered adult mixed breed cats, weighing an average of 3.5kg. The cats were randomly divided into three groups: GI, GII and GIII, according to the length of the assessment period. The assessments of their subcutaneous and bone tissues were performed at 15, 30 and 45 days and at 30, 60 and 90 days, respectively. The subcutaneous and bone reactions to the composites were characterized by granulomatous inflammation with a predominance of macrophages and giant cells. The results showed that the composites triggered a chronic local inflammatory response, despite their clinical acceptance.
authors.affiliation: Department of Veterinary Medicine and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Endrigo Gabellini Leonel
authors.initials: EG
authors.lastname: Alves
authors.forename: Cleuza Maria de Faria
authors.initials: CM
authors.lastname: Rezende
authors.forename: Rogéria
authors.initials: R
authors.lastname: Serakides
authors.forename: Marivalda de Magalhães
authors.initials: Mde M
authors.lastname: Pereira
authors.forename: Isabel Rodrigues
authors.initials: IR
authors.lastname: Rosado
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects; D018786:Bone Substitutes / Q000009:adverse effects* / Q000627:therapeutic use*; D002415:Cats / Q000601:surgery*; D017886:Durapatite / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D017102:Fracture Healing; D006885:Hydroxybutyrates / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D008297:Male; D009336:Necrosis; D019736:Prostheses and Implants / Q000662:veterinary; D011859:Radiography; D011897:Random Allocation
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D006885:Hydroxybutyrates; D017886:Durapatite