title: Pathological comparison between spontaneously developed and chemically induced liver cancers in LEC rats with hereditary hepatitis.
abstract: To investigate the pathological differences between spontaneously developed and chemically induced liver cancers in LEC rats with hereditary hepatitis, eight-week-old LEC rats were fed 0.06% or 0.03% of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) for 12 weeks, and then fed basal diet. Spontaneous liver cancers occurred in 60.4% of the LEC rats, while 3'-Me-DAB induced cancers in all LEC rats. The survival periods of chemically (0.06%) treated LEC rats were significantly shorter than non-treated rats. The chemically-induced cancers were strongly related to Edmondson classification. Metastasis and transplantability of the chemically-induced cancers were higher than spontaneous cancers. LEC rats are highly susceptible to the chemical carcinogen with the initiated status of hepatocarcinogenesis.
authors.affiliation: HOKKAIDO UNIV,SCH MED,CELL BIOL LAB,INST CANC,SAPPORO,HOKKAIDO 060,JAPAN. HOKKAIDO UNIV,SCH MED,PATHOL LAB,INST CANC,SAPPORO,HOKKAIDO 060,JAPAN.
authors.forename: T
authors.initials: T
authors.lastname: Namieno
authors.forename: S
authors.initials: S
authors.lastname: Konaka
authors.forename: F
authors.initials: F
authors.lastname: Okada
authors.forename: J
authors.initials: J
authors.lastname: Hamada
authors.forename: M
authors.initials: M
authors.lastname: Hosokawa
authors.forename: J
authors.initials: J
authors.lastname: Uchino
authors.forename: N
authors.initials: N
authors.lastname: Sato