title: Malaria: surprising mechanism of merozoite egress revealed.
abstract: A recent study reveals that the intraerythrocytic asexual reproduction cycle of Plasmodium falciparum ends with the ruptured erythrocyte membrane curling outwards, buckling, everting and vesiculating. Analogy with the sequence seen during spontaneous inside-out vesiculation of erythrocyte membranes suggests that the parasite co-opts pre-existing cytoskeletal conformations to facilitate terminal merozoite dispersal.
authors.affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK. vll1@cam.ac.uk
authors.forename: Virgilio L
authors.initials: VL
authors.lastname: Lew
mesh_terms: D004910:Erythrocyte Membrane / Q000469:parasitology / Q000502:physiology* / Q000648:ultrastructure; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D008288:Malaria / Q000503:physiopathology*; D052940:Merozoites / Q000502:physiology*; D008954:Models, Biological; D010963:Plasmodium falciparum / Q000502:physiology*; D012100:Reproduction, Asexual / Q000502:physiology*