title: Image reconstruction from sparse data in synchrotron-radiation-based microtomography.
abstract: Synchrotron-radiation-based microcomputed-tomography (SR-μCT) is a powerful tool for yielding 3D structural information of high spatial and contrast resolution about a specimen preserved in its natural state. A large number of projection views are required currently for yielding SR-μCT images by use of existing algorithms without significant artifacts. When a wet biological specimen is imaged, synchrotron x-ray radiation from a large number of projection views can result in significant structural deformation within the specimen. A possible approach to reducing imaging time and specimen deformation is to decrease the number of projection views. In the work, using reconstruction algorithms developed recently for medical computed tomography (CT), we investigate and demonstrate image reconstruction from sparse-view data acquired in SR-μCT. Numerical results of our study suggest that images of practical value can be obtained from data acquired at a number of projection views significantly lower than those used currently in a typical SR-μCT imaging experiment.
authors.affiliation: Institute of Biomedical and Health Engineering and Key Laboratory for Biomedical Informatics and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: D
authors.initials: D
authors.lastname: Xia
authors.forename: X
authors.initials: X
authors.lastname: Xiao
authors.forename: J
authors.initials: J
authors.lastname: Bian
authors.forename: X
authors.initials: X
authors.lastname: Han
authors.forename: E Y
authors.initials: EY
authors.lastname: Sidky
authors.forename: F
authors.initials: F
authors.lastname: De Carlo
authors.forename: X
authors.initials: X
authors.lastname: Pan
mesh_terms: D000465:Algorithms; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D012015:Reference Standards; D017356:Synchrotrons; D055114:X-Ray Microtomography / Q000295:instrumentation* / Q000592:standards