title: Of/Lb collagen promotes chemoinvasion of breast-cancer cells and directs epithelial-cell migration into granulation-tissue of experimental dermal wounds.
abstract: OF/LB collagen is a recently described once-fetal form of collagen, with laminin-binding properties, composed of three alpha(1)(I)-sized chains, one of which displaying an unusually acidic pI. This collagen appears able to direct the migration of breast cancer cells through Matrigel, and of injury-activated epithelial cells into the underlying granulation stromal tissue. The effect exerted by OF/LB collagen in vitro appears preferentially linked to its acidic chain. The data reported strongly support the hypothesis that the presence and accumulation of OF/LB collagen in cancer may play a fundamental role in the invasive growth.
authors.affiliation: UNIV PALERMO,CTR ONCOBIOL SPERIMENTALE,I-91028 PALERMO,ITALY. UNIV PALERMO,IST ISTOL & EMBRIOL,I-91028 PALERMO,ITALY. INST BIOL & CHIM PROT,CNRS,UPR 412,LYON 07,FRANCE. HEBREW UNIV JERUSALEM,HADASSAH MED SCH,CONNECT TISSUE RES LABS,JERUSALEM,ISRAEL.
authors.forename: I
authors.initials: I
authors.lastname: Pucciminafra
authors.forename: C
authors.initials: C
authors.lastname: Luparello
authors.forename: A
authors.initials: A
authors.lastname: Aquino
authors.forename: L
authors.initials: L
authors.lastname: Basirico
authors.forename: S
authors.initials: S
authors.lastname: Minafra
authors.forename: S
authors.initials: S
authors.lastname: Franc
authors.forename: L
authors.initials: L
authors.lastname: Yakovlev
authors.forename: S
authors.initials: S
authors.lastname: Shoshan