title: The toxicity evaluation of nano-trititanate with bactericidal properties in vitro.
abstract: Three forms of nano-trititanate (H(2)Ti(3)O(7) nanomaterial) were prepared by a hydrothermal method to replace nano-TiO(2) for sterilizing the environment. The bactericidal capabilities of these nano-trititanates were observed to be more significant compared to nano-TiO(2) both with and without exposure to UV light. For the future commercial applications of those nano-trititanates, we investigated their cytotoxicity and genotoxicity to HEp-2 cells. As data in our study shows, nanoplate, one of the nano-trititanates, possesses the lowest toxicity to HEp-2 cells. The results indicated that the shape and length of the material only affect the toxicity of nano-trititanate but not its bactericidal effect. Thus, through manipulating the shape or length of nano-trititanate, we may obtain a more powerful bactericidal reagent with lower toxicity to the human body.
authors.affiliation: Nanobiomedicine Division, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, PR China.
authors.forename: Rong
authors.initials: R
authors.lastname: Pan
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Graham
authors.initials: G
authors.lastname: Dawson
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Dong
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000633:toxicity*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D020552:Comet Assay; D004249:DNA Damage; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D046529:Microscopy, Electron, Transmission; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D010087:Oxides / Q000737:chemistry / Q000633:toxicity*; D010316:Particle Size; D017382:Reactive Oxygen Species / Q000378:metabolism; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000633:toxicity*; D018675:Toxicity Tests / Q000379:methods; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D009153:Mutagens; D010087:Oxides; D017382:Reactive Oxygen Species; C009495:titanium dioxide; D014025:Titanium