title: famCNV: copy number variant association for quantitative traits in families.
abstract: A program package to enable genome-wide association of copy number variants (CNVs) with quantitative phenotypes in families of arbitrary size and complexity. Intensity signals that act as proxies for the number of copies are modeled in a variance component framework and association with traits is assessed through formal likelihood testing.
  
  
  METHODS
  The Java package is made available at www.imperial.ac.uk/medicine/people/m.falchi/.
  
  
  BACKGROUND
  m.falchi@imperial.ac.uk.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK.
authors.forename: Hariklia
authors.initials: H
authors.lastname: Eleftherohorinou
authors.forename: Johanna C
authors.initials: JC
authors.lastname: Andersson-Assarsson
authors.forename: Robin G
authors.initials: RG
authors.lastname: Walters
authors.forename: Julia S
authors.initials: JS
authors.lastname: El-Sayed Moustafa
authors.forename: Lachlan
authors.initials: L
authors.lastname: Coin
authors.forename: Peter
authors.initials: P
authors.lastname: Jacobson
authors.forename: Lena M S
authors.initials: LM
authors.lastname: Carlsson
authors.forename: Alexandra I F
authors.initials: AI
authors.lastname: Blakemore
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Walley
authors.forename: Mario
authors.initials: M
authors.lastname: Falchi
mesh_terms: D056915:DNA Copy Number Variations; D004194:Disease / Q000235:genetics; D005190:Family; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D006801:Humans; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D012984:Software