title: Vascular endothelial growth factor gene polymorphisms and risk of cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  To evaluate the association between 3 vascular endothelial growth factor (VEGF) gene polymorphisms and susceptibility of cervical intraepithelial neoplasia (CIN).
  
  
  METHODS
  This prospectively collected case-control study investigates three common VEGF gene polymorphisms (ie, VEGF -460 [rs833061], VEGF +405 [rs2010963], and VEGF +936 [rs3025039]) in 203 women with CIN and 209 healthy women by DNA pyrosequencing. Associations between polymorphisms and CIN risk are evaluated with univariate and multivariable models and haplotype analysis.
  
  
  RESULTS
  In a multivariable regression model, the variant VEGF +405C allele was associated (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.2-5.1], P = 0.02) with increased susceptibility of CIN independent of number of sexual partners (OR, 2.2; 95% CI, 1.1-4.6; P = 0.03) and smoking (OR, 3.3; 95% CI, 1.6-6.6; P = 0.001). The haplotype VEGF -460C - +405C - +936C was associated with an OR of 5.2 (95% CI, 1.2-52.7) for the susceptibility of CIN.
  
  
  CONCLUSIONS
  The presence of the variant VEGF +405C allele and the haplotype VEGF -460C - +405C - +936C are independently associated with higher susceptibility of CIN.
authors.affiliation: Department of Gynecology and Gynecological Oncology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. christoph.grimm@meduniwien.ac.at
authors.forename: Christoph
authors.initials: C
authors.lastname: Grimm
authors.forename: Rafal
authors.initials: R
authors.lastname: Watrowski
authors.forename: Stephan
authors.initials: S
authors.lastname: Polterauer
authors.forename: Konstantin
authors.initials: K
authors.lastname: Baumühlner
authors.forename: Camilla
authors.initials: C
authors.lastname: Natter
authors.forename: Jasmin
authors.initials: J
authors.lastname: Rahhal
authors.forename: Georg
authors.initials: G
authors.lastname: Heinze
authors.forename: Eva
authors.initials: E
authors.lastname: Schuster
authors.forename: Lukas
authors.initials: L
authors.lastname: Hefler
authors.forename: Alexander
authors.initials: A
authors.lastname: Reinthaller
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A