title: Well-done meat intake and meat-derived mutagen exposures in relation to breast cancer risk: the Nashville Breast Health Study.
abstract: Previous studies of the association of meat intake and meat-derived mutagen exposure with breast cancer risk have produced inconsistent results. We evaluated this association in a population-based case-control study of incident breast cancer conducted in Nashville, Tennessee, United States, including 2,386 breast cancer cases and 1,703 healthy women controls. Telephone interviews were conducted to obtain information related to meat intake including amount, cooking methods, and doneness levels, as well as other known or hypothesized risk factors for breast cancer. Unconditional logistic regression was used to derive odds ratios (ORs) after adjusting for potential confounders. High intake of red meat was associated with a significantly elevated risk of breast cancer (P-trend < 0.001). The association was particularly strong for high intake of well-done red meat (P-trend < 0.001), with an adjusted OR of 1.5 (95% CI = 1.3-1.9) for the highest versus the lowest quartile. Associations between red meat and breast cancer risk were slightly stronger for postmenopausal women than for premenopausal women. Meat-derived mutagens such as 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline, were significantly associated with increased breast cancer risk among postmenopausal women only (P-trend = 0.002 and 0.003, respectively). The results from this study provide strong support for the hypotheses that high red meat intake and meat-derived mutagen exposure may be associated with an increase in breast cancer risk.
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 2525 West End Avenue, 8th floor, Suite 800, Nashville, TN 37203-1738, USA.
authors.forename: Zhenming
authors.initials: Z
authors.lastname: Fu
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Deming
authors.forename: Alecia M
authors.initials: AM
authors.lastname: Fair
authors.forename: Martha J
authors.initials: MJ
authors.lastname: Shrubsole
authors.forename: Debra M
authors.initials: DM
authors.lastname: Wujcik
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Mark
authors.initials: M
authors.lastname: Kelley
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D002273:Carcinogens / Q000633:toxicity; D016022:Case-Control Studies; D003296:Cooking; D004435:Eating; D005260:Female; D006801:Humans; D008460:Meat / Q000009:adverse effects*; D008875:Middle Aged; D009153:Mutagens / Q000009:adverse effects*; D017698:Postmenopause; D017697:Premenopause; D011810:Quinoxalines / Q000009:adverse effects; D012044:Regression Analysis; D012307:Risk Factors; D013714:Tennessee
chemical_list: D002273:Carcinogens; D009153:Mutagens; D011810:Quinoxalines; C036990:2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; C042052:2-amino-3,7,8-trimethylimidazo(4,5-f)quinoxaline