title: Association of saliva 3-methoxy-4-hydroxyphenylglycol levels and a later depressive state in older subjects living in a rural community: 3-year follow-up study.
abstract: OBJECTIVE
  The aim of the study was to examine the association of saliva levels of 3-methoxy-4-hydroxyphenylglycol (sMHPG) with a later depressive state in older people living in a rural community.
  
  
  METHODS
  Baseline sMHPG levels were measured in 214 older subjects followed by completion of the Beck Depression Inventory (BDI) from 2004 to 2006 (time A). The same cohort underwent BDI again from 2007 to 2009 (time B).
  
  
  RESULTS
  One hundred forty-four subjects (44 men, 100 women) were reassessed by the BDI. Baseline sMHPG levels in men with a BDI score of ≤9 at time A and a BDI score of ≥10 at time B were significantly higher than those in men with a BDI score of ≤9 at times A and B. In men, there was a significant correlation between baseline sMHPG levels and BDI score at time B (r = 0.40, p = 0.007) but not at time A (r = 0.29, p = 0.06). This association was not significant in women.
  
  
  CONCLUSIONS
  These data indicate that high sMHPG levels at time A could be associated with a later depressive state in older men living in a community.
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Saga University, Saga, Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Watanabe
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Li
authors.forename: Yoshiomi
authors.initials: Y
authors.lastname: Imamura
authors.forename: Hiromi
authors.initials: H
authors.lastname: Nabeta
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kunitake
authors.forename: Hironobu
authors.initials: H
authors.lastname: Ishii
authors.forename: Masanori
authors.initials: M
authors.lastname: Haraguchi
authors.forename: Naoki
authors.initials: N
authors.lastname: Kojima
authors.forename: Shigeto
authors.initials: S
authors.lastname: Yamada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D015331:Cohort Studies; D003866:Depressive Disorder / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism*; D011569:Psychiatric Status Rating Scales; D012424:Rural Population; D012463:Saliva / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D008734:Methoxyhydroxyphenylglycol