title: Biopharmaceutical characterization of some new papaverine decomposition products.
abstract: 2,3,9,10-Tetramethoxy-12-oxo-12-H-indolo[2,1-a]isoquinolinium chloride 1 (compound X) and 13-(3,4-dimethoxyphenyl)-2,3,8,9-tetramethoxy-6a, 12a-diazadibenzo[a,g] fluorenylium chloride 2 (compound NF) are new papaverine oxidation products. A solution of compound 1 bleaches on addition of sodium hydroxide solution. A new entity, 2-(2-carboxy-4,5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt 3 (compound WP), is formed. The physico-chemical properties of compounds 1-3, such as solubility in water and lipophilicity, have been measured. The IC50 for compounds 1 and 3 was also assessed.
authors.affiliation: Department of Physical Pharmacy and Pharmacokinetics, K. Marcinkowski University of Medical Sciences, Poznań, Poland. aczyrski@ump.edu.pl
authors.forename: A
authors.initials: A
authors.lastname: Czyrski
authors.forename: T
authors.initials: T
authors.lastname: Hermann
authors.forename: B
authors.initials: B
authors.lastname: Rubiś
authors.forename: M
authors.initials: M
authors.lastname: Rybczyńska
authors.forename: D
authors.initials: D
authors.lastname: Sledź
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001702:Biopharmaceutics; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000378:metabolism; D008055:Lipids / Q000737:chemistry; D010084:Oxidation-Reduction; D010208:Papaverine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D012995:Solubility; D012996:Solutions
chemical_list: C547425:2-(2-carboxy-4,5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt; D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D007546:Isoquinolines; D008055:Lipids; D012996:Solutions; D010208:Papaverine