title: Relationship between oncogene amplification, aneuploidy and altered expression of p53 in breast cancer.
abstract: Many studies have noted an association between amplification of single oncogenes and poor prognosis in breast cancer. We are investigating whether measurement of amplification in a larger number of proto-oncogenes increases the reliability of the prognostic information provided. As the first stage of this investigation, amplification (of c-erbB-2, cycD1, int-2, c-myc and MDM2), aneuploidy and altered expression of p53, which all indicate genetic instability, were studied in 117 primary breast adenocarcinomas. Amplification was correlated with aneuploidy (p=0.002) but not with altered expression of p53 even though the tumours with p53 overexpression were all aneuploid. Our results suggest that measurement of amplification is a potentially valuable prognostic factor.
authors.affiliation: KAROLINSKA INST,UNIT TUMOUR PATHOL,DEPT ONCOL PATHOL,S-17177 STOCKHOLM,SWEDEN.
authors.forename: C
authors.initials: C
authors.lastname: Latham
authors.forename: S
authors.initials: S
authors.lastname: Maner
authors.forename: H
authors.initials: H
authors.lastname: Blegen
authors.forename: E
authors.initials: E
authors.lastname: Eriksson
authors.forename: P
authors.initials: P
authors.lastname: Zickert
authors.forename: G
authors.initials: G
authors.lastname: Auer
authors.forename: A
authors.initials: A
authors.lastname: Zetterberg