title: Morphogens, nutrients, and the basis of organ scaling.
abstract: The regulation of organ size is a long-standing problem in animal development. Studies in this area have shown that organ-intrinsic patterning morphogens influence organ size, guiding growth in accordance with positional information. However, organ-extrinsic humoral factors such as insulin also affect organ size, synchronizing growth with nutrient levels. Proliferating cells must integrate instructions from morphogens with those from nutrition so that growth proceeds as a function of both inputs. Coordinating cell proliferation with morphogens and nutrients ensures organs scale appropriately with body size, but the basis of this coordination is unclear. Here, the problem is illustrated using the Drosophila wing--a paradigm for organ growth and size control--and a potential solution suggested.
authors.affiliation: Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA. jp2488@columbia.edu
authors.forename: Joseph
authors.initials: J
authors.lastname: Parker
mesh_terms: D000818:Animals; D019521:Body Patterning; D049109:Cell Proliferation; D004330:Drosophila / Q000235:genetics / Q000254:growth & development* / Q000502:physiology; D009024:Morphogenesis; D009929:Organ Size; D014921:Wings, Animal / Q000254:growth & development / Q000502:physiology