title: Phentolamine action in permeability of airways at patients with bronchial asthma.
abstract: In this work, effect of phentolamine as antagonist of alpha-1 adrenergic receptor in patients with bronchial asthma and with obstructive chronic bronchitis was studied. Parameters of the lung function are determined by body plethysmography. Raw and ITGV were registered and SRaw was calculated as well. Aerosolization is done with standard aerosolizing machines--Asthma with a possibility of aerosolization of 0.5 ml per minute. Results gained by this research shows that blockage of alpha-1 adrenergic receptor with phentolamine (10 mg by inhalator and intravenous ways and 20 mg by inhalator ways) has not changed significantly (p > 0.1) the bronchomotor tonus of tracheobronchial tree, by comparing it with the inhalation of natrium chloride solution with percentage of 0.9% (p > 0.1), or of hexoprenaline (2 inh x 0.2 mg) and atropine 1 mg/ml (p < 0.01). This suggests that the activity of alpha-1 adrenergic receptor in the smooth musculature is not a primary mechanism that causes reaction in patients with increased bronchial reactibility, in comparison to agonists of beta2--adrenergic receptor and cholinergic antagonists that expresses their significant action in reduction of specific resistance of airways.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Institute of Clinical Pharmacology and Toxicology, University of Prishtina, Clinical Centre N. N. 10000, Prishtina, Kosova. islamihilmi@hotmail.com
authors.forename: Hilmi
authors.initials: H
authors.lastname: Islami
authors.forename: Shaip
authors.initials: S
authors.lastname: Krasniqi
authors.forename: Halil
authors.initials: H
authors.lastname: Ahmetaj
authors.forename: Naim
authors.initials: N
authors.lastname: Haliti
authors.forename: Ilir
authors.initials: I
authors.lastname: Kurtishi
authors.forename: Salih
authors.initials: S
authors.lastname: Ahmetaj
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ibrahimi
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology*; D000403:Airway Resistance; D001249:Asthma / Q000503:physiopathology*; D001980:Bronchi / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D010539:Permeability; D010646:Phentolamine / Q000494:pharmacology*; D010993:Plethysmography, Whole Body
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D010646:Phentolamine