title: On the synthesis of conformationally modified peptides through isonitrile chemistry: implications for dealing with polypeptide aggregation.
abstract: A method for introducing a dimethyleneoxy constraint joining the N atoms of two consecutive amino acids in the context of a polypeptide has been developed. This constraint can profoundly affect the tendency of a polypeptide to suffer aggregation and desolubilization, and it can be readily removed under mild conditions.
authors.affiliation: Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Wu
authors.forename: Peter K
authors.initials: PK
authors.lastname: Park
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D009570:Nitriles / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011487:Protein Conformation; D012995:Solubility
chemical_list: D009570:Nitriles; D010455:Peptides