title: The effects of the hydroalcohol extract of Rosa canina L. fruit on experimentally nephrolithiasic Wistar rats.
abstract: This research evaluated the possible therapeutic potential of Rosa canina (RC) as a preventive agent in experimentally induced calcium oxalate (CaOx) nephrolithiasis with ethylene glycol (1% EG) in rats. In this experiment, 50 Wistar rats were divided randomly into five groups (n = 10). These groups received tap drinking water (group I), 1% EG (group II), 250 mg/kg RC + 1% EG (group III), 500 mg/kg RC + 1% EG (group IV), or 2.5 g/kg potassium citrate + 1% EG (group V) for a period of 30 days. Blood and urine were collected for biochemical analysis, and the liver and kidneys were prepared for total lipid peroxides, calcium content and histological evaluation. The extract was analysed for total phenolics, flavonoids, ascorbic acid, citric acid and radical scavenger activity. The supplementation of the hydromethanol RC extract contributed to reducing the kidney and liver lipid peroxides to optimum levels in rats that had been treated with EG-induced CaOx lithiasis. The extract also decreased renal and urinary calcium contents, decreased the size and number of CaOx calculi in the kidneys, and significantly increased citrate excretion without changing the volume, pH, or urinary concentrations of oxalate in comparison with the control group. According to these results, RC can be useful as a preventive agent against the formation of CaOx kidney stones.
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran. tayefi@tabrizu.ac.ir
authors.forename: Hossein
authors.initials: H
authors.lastname: Tayefi-Nasrabadi
authors.forename: Saeed
authors.initials: S
authors.lastname: Sadigh-Eteghad
authors.forename: Zahra
authors.initials: Z
authors.lastname: Aghdam
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D002129:Calcium Oxalate / Q000378:metabolism*; D019343:Citric Acid / Q000378:metabolism; D019587:Dietary Supplements; D060766:Drinking Water; D019855:Ethylene Glycol; D005638:Fruit; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007669:Kidney Calculi / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D019357:Potassium Citrate / Q000008:administration & dosage; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D027826:Rosa / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D060766:Drinking Water; D008054:Lipid Peroxides; D010936:Plant Extracts; D002129:Calcium Oxalate; D019343:Citric Acid; D019357:Potassium Citrate; D019855:Ethylene Glycol; D002118:Calcium