title: Cardenolides and diterpenes as a source of and model for positive ionotropic agents.
abstract: Taking the natural cardenolides as a model for new inotropic agents, pimaranic, cyclohexanic and hydroindenic derivatives have been synthesized and tested. Several of these derivatives are positive inotropics and two of the D3a-unsaturated bis(amidinohydrazono)hydroinenes also are selective Na(+), K(+)-ATPase inhibitors.
authors.affiliation: Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Medarde
authors.forename: E
authors.initials: E
authors.lastname: Caballero
authors.forename: F
authors.initials: F
authors.lastname: Tomé
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano