title: Kaposi's sarcoma-associated herpesvirus infection of endothelial progenitor cells impairs angiogenic activity in vitro.
abstract: A recent study reported that endothelial progenitor cells (EPCs0 are one of the reservoirs of Kaposi's sarcoma associated herpesvirus (KSHV). Although EPCs are closely linked to angiogenesis and vasculogenesis, little is known about the angiogenic potential of KSHV in EPCs. In this study, we used EPCs isolated from human umbilical cord blood to show that early infection by KSHV in vitro impaired the neovascularization of EPCs in matrigel. Our results suggest that KSHV may disrupt the angiogenic potential of EPCs and that the disseminated infection of KSHV could be associated with EPC dysfunction.
authors.affiliation: Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 301-746, Republic of Korea.
authors.forename: Seungchul
authors.initials: S
authors.lastname: Yoo
authors.forename: Sil
authors.initials: S
authors.lastname: Kim
authors.forename: Seungmin
authors.initials: S
authors.lastname: Yoo
authors.forename: In-Taek
authors.initials: IT
authors.lastname: Hwang
authors.forename: Haewol
authors.initials: H
authors.lastname: Cho
authors.forename: Myung-Shin
authors.initials: MS
authors.lastname: Lee
mesh_terms: D002478:Cells, Cultured; D042783:Endothelial Cells / Q000502:physiology* / Q000821:virology*; D005312:Fetal Blood / Q000166:cytology; D019288:Herpesvirus 8, Human / Q000472:pathogenicity*; D006801:Humans; D018919:Neovascularization, Physiologic