title: [Antiradical and NO-inhibiting activities of bet-hydroxy(ethoxy) derivatives of nitrous heterocycles].
abstract: The antiradical and NO-inhibiting activities of beta-hydroxy(ethoxy) derivatives of nitrous heterocycles (3-hydroxypyridine, 5-hydroxybenzimodazole, and 6-hydroxy(alkoxy)-benzothiazole) have been studied. The antiradical activity has been studied using a homogeneous hydrophilic chemiluminescent system, and the quenching constants (Ki) have been determined. For the most reactive compound, 4-methylthiobenzimidazolyl-3-hydroxypyridine, Ki = 4.5 x 105 M(-1). The NO-inhibiting activity was estimated on a model of the endotoxin shock of experimental animals using a spin trap of nitric oxide radicals based on complexes of iron with sodium diethyldithiocarbamate. It was found that the compounds at doses of 0.25-1 mmol/kg have both the inhibitory and stimulating action on the production of nitric oxide in the liver of animals. The results obtained suggest that some derivatives of nitrous heterocycles can be used as effective antioxidant preparations.
authors.forename: L D
authors.initials: LD
authors.lastname: Smirnov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Kuznetsov
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Proskuriakov
authors.forename: V G
authors.initials: VG
authors.lastname: Skvortsov
authors.forename: T N
authors.initials: TN
authors.lastname: Nosko
authors.forename: A E
authors.initials: AE
authors.lastname: Dontsov
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D012772:Shock, Septic / Q000188:drug therapy* / Q000378:metabolism*; D019097:Spin Trapping
chemical_list: D016166:Free Radical Scavengers; D006571:Heterocyclic Compounds; D009569:Nitric Oxide