title: Metal-containing peptide nucleic acid conjugates.
abstract: Peptide Nucleic Acids (PNAs) are non-natural DNA/RNA analogues with favourable physico-chemical properties and promising applications. Discovered nearly 20 years ago, PNAs have recently re-gained quite a lot of attention. In this Perspective article, we discuss the latest advances on the preparation and utilisation of PNA monomers and oligomers containing metal complexes. These metal- conjugates have found applications in various research fields such as in the sequence-specific detection of nucleic acids, in the hydrolysis of nucleic acids and peptides, as radioactive probes or as modulators of PNA·DNA hybrid stability, and last but not least as probes for molecular and cell biology.
authors.affiliation: Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland. gilles.gasser@aci.unizh.ch
authors.forename: Gilles
authors.initials: G
authors.lastname: Gasser
authors.forename: Anna M
authors.initials: AM
authors.lastname: Sosniak
authors.forename: Nils
authors.initials: N
authors.lastname: Metzler-Nolte
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods; D002384:Catalysis; D002463:Cell Membrane Permeability; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D003851:Deoxyribonucleases / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D010084:Oxidation-Reduction; D010447:Peptide Hydrolases / Q000378:metabolism; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D012260:Ribonucleases / Q000378:metabolism
chemical_list: D056831:Coordination Complexes; D003432:Cross-Linking Reagents; D020135:Peptide Nucleic Acids; D004247:DNA; D003851:Deoxyribonucleases; D012260:Ribonucleases; D010447:Peptide Hydrolases