title: Impaired osmoregulation in anorexia nervosa: review of the literature.
abstract: BACKGROUND
  Anorexia nervosa (AN) is a serious eating disorder associated with numerous medical complications, including alterations in water balance and impaired osmoregulation.
  
  
  OBJECTIVE
  The aim of this paper is to review the evidence-based literature and discuss the potential pathophysiological mechanisms of impaired osmoregulation observed in patients with AN.
  Although limited, the evidence suggests that the pathophysiological mechanisms causing impaired osmoregulation in AN is multifactorial and includes abnormalities in osmoregulation of vasopressin, intrinsic renal defects and the influence of antidepressants often used in the treatment of patients with AN. Physicians treating patients with AN should be aware of this complication and the possible multifactorial etiology contributing to this medical complication.
authors.affiliation: Division of Adolescent Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Nuray
authors.initials: N
authors.lastname: Kanbur
authors.forename: Debra K
authors.initials: DK
authors.lastname: Katzman
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000150:complications* / Q000503:physiopathology; D000928:Antidepressive Agents / Q000009:adverse effects; D019317:Evidence-Based Medicine; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000503:physiopathology; D014667:Vasopressins / Q000502:physiology; D014883:Water-Electrolyte Imbalance / Q000209:etiology* / Q000503:physiopathology
chemical_list: D000928:Antidepressive Agents; D014667:Vasopressins