title: Palladium-catalyzed decarboxylative arylation of potassium cyanoacetate: synthesis of α-diaryl nitriles from aryl halides.
abstract: A palladium-catalyzed decarboxylative coupling of potassium cyanoacetate with aryl bromides and chlorides is described. The reaction conditions feature the absence of additional strong inorganic bases and provide ester functional group tolerance. With Pd(dba)(2) and XPhos ligand as the catalyst system, α-diaryl nitriles can be obtained in good yields.
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
authors.forename: Pui Yee
authors.initials: PY
authors.lastname: Yeung
authors.forename: Kin Ho
authors.initials: KH
authors.lastname: Chung
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry* / Q000528:radiation effects; D011188:Potassium / Q000737:chemistry*
chemical_list: D006846:Hydrocarbons, Halogenated; D008024:Ligands; D009570:Nitriles; D010165:Palladium; D011188:Potassium