title: Olanzapine degradation kinetics in aqueous solution.
abstract: The degradation kinetics of olanzapine as a function of pH and temperature has been studied by a spectrophotometric method. The degradation reaction rates were observed to follow first-order kinetics with respect to olanzapine. The hydrolytic reaction was shown to be hydrogen and hydroxide ion-catalyzed and the Arrhenius plots showed the temperature dependence of olanzapine degradation.
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria. cjmbah123@yahoo.com
authors.forename: C J
authors.initials: CJ
authors.lastname: Mbah
mesh_terms: D000465:Algorithms; D014150:Antipsychotic Agents / Q000737:chemistry*; D001569:Benzodiazepines / Q000737:chemistry*; D002384:Catalysis; D004355:Drug Stability; D007700:Kinetics; D000077152:Olanzapine; D012015:Reference Standards; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D014867:Water
chemical_list: D014150:Antipsychotic Agents; D012996:Solutions; D014867:Water; D001569:Benzodiazepines; D000077152:Olanzapine