title: [Association of miRNAs expression profiles with prognosis and relapse in childhood acute lymphoblastic leukemia].
abstract: OBJECTIVE
  To screen childhood ALL related microRNAs (miRNAs), analyze association of miRNAs expression profiles with prognosis and relapse in childhood acute lymphoblastic leukemia (ALL) and explore new indicator for predicting relapse and prognosis.
  
  
  METHODS
  miRNAs expression profile was analyzed by gene chip in 49 newly diagnosed childhood ALL and 12 primary immune thrombocytopenia (ITP) cases (as control group). Abnormal expression of miRNAs was verified by qRT-PCR. The correlation of miRNAs expression pattern with indicators predicting early prednisone response and relapse within a year was analyzed.
  
  
  RESULTS
  Specific expression of miRNAs profiles associated with prednisone response and early relapse in childhood ALL was identified. Eight miRNAs (miR-18a, miR-532, miR-218, miR-625, miR-193a, miR-638, miR-550 and miR-633) could distinguish prednisone sensitive from insensitive. The early relapse of newly diagnosed patients with either high-risk or non-high-risk clinical types had some characteristics of abnormal expression of miRNAs, including miR-7, miR-216 and let-7i upregulated, while miR-486, miR-191, miR-150, miR-487 and miR-342 downregulated.
  
  
  CONCLUSIONS
  The initial screening reveals miRNAs differentially expressed from normal in ALL suggesting the potential roles of them in leukemogenesis. MiRNAs expression signatures may be useful for predicting prognosis and relapse in childhood ALL and directing personalized treatment.
authors.affiliation: The Centre of Medical Research of Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Yan-ni
authors.initials: YN
authors.lastname: Liang
authors.forename: Xue-qun
authors.initials: XQ
authors.lastname: Luo
authors.forename: Xiao-dan
authors.initials: XD
authors.lastname: Liu
authors.forename: Hai-xia
authors.initials: HX
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D011379:Prognosis; D012008:Recurrence; D059467:Transcriptome
chemical_list: C585583:MIRN532 microRNA, human; D035683:MicroRNAs