title: Current status and prospects of antiplatelet therapy in percutaneous coronary intervention in Japan: focus on adenosine diphosphate receptor inhibitors.
abstract: Dual antiplatelet therapy with aspirin and clopidogrel is routinely used to prevent thrombotic events in patients with acute coronary syndrome undergoing percutaneous coronary intervention (PCI) in Japan. However, these agents have various limitations and some patients will experience further cardiovascular events. The purpose of this article is to review the antiplatelet agents currently used in patients undergoing PCI in Japan, to discuss the issues and limitations associated with these antiplatelet agents, and to characterize new antiplatelet agents currently under investigation in Japan. Particular emphasis is placed on the novel thienopyridine prasugrel, and the potential this drug has for overcoming the issues associated with other antiplatelet agents.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. ogawah@kumamoto-u.ac.jp
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
authors.forename: Seiji
authors.initials: S
authors.lastname: Hokimoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Kaikita
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Tadasuke
authors.initials: T
authors.lastname: Chitose
authors.forename: Takamichi
authors.initials: T
authors.lastname: Ono
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tsujita
mesh_terms: D054058:Acute Coronary Syndrome / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D010879:Piperazines / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D000068799:Prasugrel Hydrochloride; D058921:Purinergic P2Y Receptor Antagonists / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use; D013927:Thrombosis / Q000517:prevention & control
chemical_list: D010879:Piperazines; D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D013876:Thiophenes; D000068799:Prasugrel Hydrochloride