title: Beta-arrestin-1 protein represses diet-induced obesity.
abstract: Diet-related obesity is a major metabolic disorder. Excessive fat mass is associated with type 2 diabetes, hepatic steatosis, and arteriosclerosis. Dysregulation of lipid metabolism and adipose tissue function contributes to diet-induced obesity. Here, we report that β-arrestin-1 knock-out mice are susceptible to diet-induced obesity. Knock-out of the gene encoding β-arrestin-1 caused increased fat mass accumulation and decreased whole-body insulin sensitivity in mice fed a high-fat diet. In β-arrestin-1 knock-out mice, we observed disrupted food intake and energy expenditure and increased macrophage infiltration in white adipose tissue. At the molecular level, β-arrestin-1 deficiency affected the expression of many lipid metabolic genes and inflammatory genes in adipose tissue. Consistently, transgenic overexpression of β-arrestin-1 repressed diet-induced obesity and improved glucose tolerance and systemic insulin sensitivity. Thus, our findings reveal that β-arrestin-1 plays a role in metabolism regulation.
authors.affiliation: Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and.
authors.forename: Le-nan
authors.initials: LN
authors.lastname: Zhuang
authors.forename: Wen-xiang
authors.initials: WX
authors.lastname: Hu
authors.forename: Ming-liang
authors.initials: ML
authors.lastname: Zhang
authors.forename: Shun-mei
authors.initials: SM
authors.lastname: Xin
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Jia
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.forename: Gang
authors.initials: G
authors.lastname: Pei
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D019390:Arrestins / Q000235:genetics / Q000378:metabolism*; D001835:Body Weight; D004041:Dietary Fats / Q000009:adverse effects* / Q000494:pharmacology; D004435:Eating; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D050356:Lipid Metabolism; D051379:Mice; D018345:Mice, Knockout; D009765:Obesity / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D000071559:beta-Arrestin 1; D000071557:beta-Arrestins
chemical_list: C000605255:Arrb1 protein, mouse; D019390:Arrestins; D004041:Dietary Fats; D007328:Insulin; D000071559:beta-Arrestin 1; D000071557:beta-Arrestins