title: Biological predictors of response to radiotherapy in cervical carcinomas.
abstract: On 21 patients with T1b-T3b tumours subjected to external radiotherapy and brachytherapy, the expression of P53 and glutathione S-transferase pi [GST-pi], immunohistochemically detected, the S-phase cells fraction (H-3-thymidine labeling index, TLI) and DNA content evaluated by image analysis were determined on biopsies before and after the first 10 Gy. P53 accumulation was reduced in 60% of P53-overexpressing tumours and not induced in P53-negative tumours, GST-pi was induced in about 40% of pretreatment GST-pi-negative cases, TLI was reduced in 70% of the cases regardless of pretreatment values, and DNA profiles remained unchanged in two-thirds of the cases. P53 accumulation was a predictor of 3-year relapse-free survival after radiotherapy, followed by GST-pi expression, whereas TLI did not influence prognosis.
authors.affiliation: IST NAZL TUMORI,I-20133 MILAN,ITALY. UNIV TURIN,DEPT RADIOL,TURIN,ITALY.
authors.forename: M
authors.initials: M
authors.lastname: Daidone
authors.forename: U
authors.initials: U
authors.lastname: Ricardi
authors.forename: S
authors.initials: S
authors.lastname: Veneroni
authors.forename: A
authors.initials: A
authors.lastname: Faranda
authors.forename: E
authors.initials: E
authors.lastname: Benini
authors.forename: A
authors.initials: A
authors.lastname: Urgesi
authors.forename: G
authors.initials: G
authors.lastname: Sannazzari
authors.forename: R
authors.initials: R
authors.lastname: Silvestrini