title: [Prospects of designing the medicines with diverse therapeutic activity on the basis of dinitrosyl iron complexes with thiol-containing ligands].
abstract: A stable hypotensive preparation (Oxacom) based on dinitrosyl iron complexes (DNIC) with glutathione has been developed. The preparation has successfully passed through pharmacological trials. The tests on volunteers have shown a high hypotensive activity of the preparation: a single intravenous infusion of its aqueous solution at a dose of 0.2 microM per kg of body weight led to a 20-30% decrease in arterial pressure, which persisted for a period of 15-20 h. Similar experiments on the animals demonstrated that aqueous solutions of DNIC with cysteine or glutathione exert also the hypotensive action due to their vasodilatory activity. Besides, these complexes accelerate wound healing and produce a potent erective action. There is reason to suggest that DNIC with thiol-containing ligands as NO donors can produce the cytotoxic action on the pathogenic mycobacteria Mycobacterium tuberculosis and, after respective treatment, inhibit cancer cell proliferation. These complexes can be used as analgetics, for inhibiting the adhesion process, in the therapy of preexplampsia, spermatogenesis pathologies, and in cosmetology for the treatment of skin injury.
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
authors.forename: E I
authors.initials: EI
authors.lastname: Chazov
mesh_terms: D000818:Animals; D003545:Cysteine / Q000627:therapeutic use*; D007172:Erectile Dysfunction / Q000188:drug therapy; D005260:Female; D005978:Glutathione / Q000627:therapeutic use*; D006801:Humans; D007501:Iron / Q000627:therapeutic use*; D008024:Ligands; D008297:Male; D009169:Mycobacterium tuberculosis; D009369:Neoplasms / Q000188:drug therapy; D009589:Nitrogen Oxides / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000188:drug therapy; D011247:Pregnancy; D014376:Tuberculosis / Q000188:drug therapy; D014665:Vasodilator Agents / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D008024:Ligands; D009589:Nitrogen Oxides; D014665:Vasodilator Agents; C073661:dinitrosyl iron complex; D007501:Iron; D005978:Glutathione; D003545:Cysteine