title: Dexamethasone inhibits invasiveness of a human pancreatic cancer cell line.
abstract: Recent studies have shown that dexamethasone inhibits gelatinases. We investigated the effect of dexamethasone on the invasiveness of a human pancreatic cancer cell line. Tumor cells were treated with dexamethasone at various concentrations for 24 h. Cells were examined in an invasion assay. The expression and activity of MMP-9 in culture media were quantitated by Western blotting and gelatin zymogram. The invasiveness of cancer cells and expression of MMP-9 were decreased by dexamethasone in a dose-dependent manner. Dexamethasone may be a useful therapeutic agent in the treatment of pancreatic cancer.
authors.forename: M
authors.initials: M
authors.lastname: Hirata
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: A
authors.initials: A
authors.lastname: Tsuchida
authors.forename: H
authors.initials: H
authors.lastname: Ooishi
authors.forename: K
authors.initials: K
authors.lastname: Hanada
authors.forename: G
authors.initials: G
authors.lastname: Kajiyama