title: Fish consumption reduces transfer of BDE47 from dam to murine offspring.
abstract: Fish and seafood are important contributions to a healthy diet, but also contain persistent organic pollutants (POPs) like polybrominated diphenylethers (PBDEs) and polychlorinated biphenyls (PCBs). Discrepancies have been found between intake and accumulated levels of POPs, where fish consumers have had similar levels of POPs to the general population. Similarly fish oil consumption has been found to reduce accumulation of POPs. This study examined the accumulation of BDE47 or PCB153 in mice fed diets with different nutritional composition, using female mice with pre-weanling pups exposed through gestation and lactation. A fish-based diet was compared to a standard casein-based rodent diet. All diets had low background levels of environmental contaminants and were spiked with BDE47 or PCB153 to levels representing a realistic (∼0.004 μmol kg bw(-1) d) or a high dietary exposure (∼1.3 μmol kg bw(-1) d). Accumulation of BDE47 or PCB153 in offspring tissues after 18d lactation reflected the maternal exposure levels. However, the pups of dams fed a fish-based diet had consistently lower BDE47 accumulation in liver, fat and stomach than pups from casein-fed dams. Similarly the pups of dams fed a high dose of PCB153 in a fish diet also accumulated less PCB153 than pups of the dams fed a casein diet, although not significant. In conclusion, the fish based diets seemed to reduce transfer of BDE47 and PCB153 from dams to pups. The study highlights that in-depth knowledge about nutritional impact on toxicokinetics is of great interest to vulnerable consumers.
authors.affiliation: National Institute of Nutrition and Seafood Research (NIFES), P.O. Box 2029 Nordnes, N-5817 Bergen, Norway. mha@nifes.no
authors.forename: Marte
authors.initials: M
authors.lastname: Haave
authors.forename: Annette
authors.initials: A
authors.lastname: Bernhard
authors.forename: Kristin I
authors.initials: KI
authors.lastname: Folven
authors.forename: Trond
authors.initials: T
authors.lastname: Brattelid
authors.forename: Anne-Katrine
authors.initials: AK
authors.lastname: Lundebye
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004032:Diet / Q000379:methods* / Q000706:statistics & numerical data; D004785:Environmental Pollutants / Q000378:metabolism*; D005260:Female; D005399:Fishes; D005753:Gastric Mucosa / Q000378:metabolism; D055768:Halogenated Diphenyl Ethers; D006801:Humans; D008099:Liver / Q000378:metabolism; D018811:Maternal Exposure; D051379:Mice; D011075:Polybrominated Biphenyls / Q000378:metabolism*
chemical_list: D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D011075:Polybrominated Biphenyls; C511295:2,2',4,4'-tetrabromodiphenyl ether