title: Treatment of schistosomiasis-associated pulmonary hypertension.
abstract: Schistosomiasis mansoni is the third most prevalent endemic parasitic disease in the world. It is estimated that over 200 million people are infected with parasites belonging to one of the Schistosoma species. Of those, 270,000 people (4.6%) suffer from pulmonary arterial hypertension, which is associated with the hepatosplenic form of the disease. This high prevalence makes schistosomiasis-associated pulmonary hypertension the leading cause of pulmonary hypertension worldwide. However, no specific treatment for the pulmonary vascular component of the disease has yet been devised. We report the case of a patient with schistosomiasis-associated pulmonary hypertension who was treated satisfactorily with a phosphodiesterase-5 inhibitor (sildenafil).
authors.affiliation: Department of Pulmonology and Thoracic Surgery, Federal University of Minas Gerais School of Medicine, Belo Horizonte, Brazil. racorrea9@gmail.com
authors.forename: Ricardo de Amorim
authors.initials: Rde A
authors.lastname: Correa
authors.forename: Marcus Vinicius Souza Couto
authors.initials: MV
authors.lastname: Moreira
authors.forename: Jucielle Marcelina da Silva
authors.initials: JM
authors.lastname: Saraiva
authors.forename: Eliane Viana
authors.initials: EV
authors.lastname: Mancuzo
authors.forename: Luciana Cristina dos Santos
authors.initials: LC
authors.lastname: Silva
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Lambertucci
mesh_terms: D000328:Adult; D005080:Exercise Test; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000469:parasitology; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines / Q000627:therapeutic use; D012552:Schistosomiasis / Q000150:complications*; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D016138:Walking / Q000502:physiology
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate