title: Ovarian germline stem cells in the teleost fish, medaka (Oryzias latipes).
abstract: In the mammalian testis germline stem cells keep producing many sperms, while there is no direct evidence for the presence of germline stem cells in the ovary. It is widely accepted in mammals that the mature oocytes are supplied from a pool of primordial follicles in the adult ovary. In other vertebrates, such as fish, however, there has been no investigation on the mechanism underlying the high egg-producing ability. In this review, we introduce the recently identified ovarian germline stem cells and the surrounding unique structure in teleost fish, medaka (Oryzias latipes) [Nakamura S et al. Science. 2010; 328: 1561-1563]. We also discuss about the expression and function of sox9 that characterizes this unique structure.
authors.affiliation: Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444-8787, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kayo
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Toshiya
authors.initials: T
authors.lastname: Nishimura
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D005260:Female; D009990:Oryzias / Q000033:anatomy & histology* / Q000502:physiology; D010053:Ovary / Q000166:cytology*; D055758:SOX9 Transcription Factor / Q000378:metabolism / Q000502:physiology; D013234:Stem Cells / Q000166:cytology*
chemical_list: D055758:SOX9 Transcription Factor