title: Preoperative prediction of postoperative reserve hepatic function for liver surgery for hepatobiliary, pancreatic cancer.
abstract: To perform safer hepatic resection for hepatobiliary-pancreatic cancer, the possibility of preoperative prediction of postoperative reserve hepatic function was assessed using hepatobiliary scintigraphy. After intravenous administration of Tc-99m-pyridoxyl-5-methyltryptophan in 23 patients, the time-activity curves of region of interest over the heart and liver were generated, and peak and one-fourth clearance times were calculated, which were compared with biochemical data. The parameters were significantly related to protein syntheses (prothrombine time and hepaplastin test) and indocyanine-green dye excretion, but not to hepatobiliary enzymes. So we hypothesized 'when the curve left by subtracting the resected area from the whole liver was larger than one-third of the total liver curve, the surgery would be safe', which we applied to another eight patients, clarifying the hypothesis. Hepatobiliary scintigraphy can be a promising procedure in the assessment of partial liver function, and the study will contribute to a safer liver surgery.
authors.affiliation: SAPPORO MED UNIV,DEPT RADIOL,SAPPORO,HOKKAIDO 060,JAPAN.
authors.forename: T
authors.initials: T
authors.lastname: Namieno
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Koito
authors.forename: T
authors.initials: T
authors.lastname: Shimamura
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Une
authors.forename: K
authors.initials: K
authors.lastname: Yamashita