title: Brominated arginine-derived alkaloids from the red sea sponge Suberea mollis.
abstract: Investigation of a new collection of the Red Sea sponge Suberea mollis afforded two new brominated arginine-derived alkaloids, subereamines A (1) and B (2), a new brominated phenolic compound, subereaphenol D (3), and the known compounds dichloroverongiaquinol (4), aerothionin (5), and purealdin L (6). The structures of the isolated compounds were assigned using one- and two-dimensional NMR spectra and HRFABMS data. The absolute configurations of subereamines A (1) and B (2) were determined by acid hydrolysis followed by chiral-phase LC-MS. The antimicrobial and antioxidant activities of the isolated compounds have been evaluated. Dichloroverongiaquinol and subereaphenol D displayed significant antimicrobial activity. Using the DPPH TLC autographic rapid screen for free radical scavenging effects, subereaphenol D displayed a significant antioxidant effect. In addition, the cytotoxic activities of the isolated compounds were investigated.
authors.affiliation: King Fahd Center for Medical Research, King Abdulaziz University, Kingdom of Saudi Arabia.
authors.forename: Lamiaa A
authors.initials: LA
authors.lastname: Shaala
authors.forename: Faida H
authors.initials: FH
authors.lastname: Bamane
authors.forename: Jihan M
authors.initials: JM
authors.lastname: Badr
authors.forename: Diaa T A
authors.initials: DT
authors.lastname: Youssef
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001120:Arginine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019156:Indian Ocean; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D006842:Hydrocarbons, Brominated; D010851:Picrates; C561439:subereamine A; C561440:subereamine B; C561441:subereaphenol D; D001120:Arginine; C004931:1,1-diphenyl-2-picrylhydrazyl