title: Stem cell associated genes working with one miRNA cluster have different clinic pathologic values in gastric cancer.
abstract: Cancer stem cells are nowadays considered to be the origin of cancer. Also, stem cell associated genes are emerging as predictors of cancer malignancy. We investigated the association of several stemness genes (c-Myc, PTEN, p57 and p21) with clinic pathological parameters and survival in stomach cancer by performing immunohistochemistry on paraffin sections of gastric cancer patients who underwent surgical staging with following-up statistics. We discovered that expression of c-Myc was significantly related to distant metastasis, the combined expression of PTEN and p21 correlated positively to overall survival, while p57 was less useful in overall survival prediction in gastric cancer. Additionally, there is a positive correlation between expressions of p57 and p21. In conclusion, our present study indicated that expression of stemness genes (c-Myc, PTEN, p57 and p21) performed different predictive potential in the evaluation of clinical malignancy levels in gastric cancer.
authors.affiliation: State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi 710032, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Yang
authors.forename: Sijun
authors.initials: S
authors.lastname: Hu
authors.forename: Tao
authors.initials: T
authors.lastname: Su
authors.forename: Yanxin
authors.initials: Y
authors.lastname: An
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yongzhan
authors.initials: Y
authors.lastname: Nie
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Shi
authors.forename: Daiming
authors.initials: D
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics; D050761:Cyclin-Dependent Kinase Inhibitor p57 / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D051059:PTEN Phosphohydrolase / Q000235:genetics; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D015996:Survival Rate
chemical_list: C493956:CDKN1A protein, human; C493964:CDKN1C protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D050761:Cyclin-Dependent Kinase Inhibitor p57; C489427:MYC protein, human; D035683:MicroRNAs; D016271:Proto-Oncogene Proteins c-myc; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human