title: Low-dose radiation therapy of cancer: role of immune enhancement.
abstract: The efficacy of conventional radiation therapy, one of the most widely used treatment modalities of cancer, is limited by resistance of tumors as well as normal tissue toxicity. In the last decade, several studies have shown that protocols using low-dose radiation (LDR) are more effective in providing local tumor control with negligible normal tissue toxicity. LDR stimulates antioxidant capacity, repair of DNA damage, apoptosis and induction of immune responses, which might be collectively responsible for providing effective local tumor control. This article focuses on the immunostimulatory effects of LDR in in vivo models and its clinical efficacy, supporting the use of LDR regimens (alone or as adjuvant) as an anticancer treatment.
authors.affiliation: Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Road, Delhi 110 0054, India.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Farooque
authors.forename: Rohit
authors.initials: R
authors.lastname: Mathur
authors.forename: Amit
authors.initials: A
authors.lastname: Verma
authors.forename: Vandana
authors.initials: V
authors.lastname: Kaul
authors.forename: Anant Narayan
authors.initials: AN
authors.lastname: Bhatt
authors.forename: Jawahar Singh
authors.initials: JS
authors.lastname: Adhikari
authors.forename: Farhat
authors.initials: F
authors.lastname: Afrin
authors.forename: Saurabh
authors.initials: S
authors.lastname: Singh
authors.forename: Bilikere S
authors.initials: BS
authors.lastname: Dwarakanath
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000528:radiation effects; D017209:Apoptosis / Q000528:radiation effects; D004260:DNA Repair / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology*; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage
chemical_list: D000975:Antioxidants