title: Prevalence of p53 overexpression or mutations, but not k-ras mutations, in recurrent patients affected by colorectal-carcinoma.
abstract: In order to establish prognostic indicators of poor clinical evolution in colorectal cancer, we have studied p53 abnormalities and K-ras mutations in 65 patients affected by colorectal carcinoma who had undergone radical surgery. A single event of p53 protein overexpression or p53 mutation, but not K-ras mutation, was significantly prevalent in recurrent tumors. A double event of K-ras mutation and p53 protein overexpression was prevalent in patients showing Dukes' stage C, but showed a lack of prevalence in patients who recurred. The presence of p53 protein overexpression does not assure an underlying mutation in colorectal carcinoma.
authors.affiliation: UNIV COMPLUTENSE MADRID,FAC FARM,DEPT BIOQUIM & BIOL MOLEC,E-28040 MADRID,SPAIN. HOSP UNIV SAN CARLOS,SERV ANAT PATOL,MADRID,SPAIN. HOSP UNIV SAN CARLOS,SERV ONCOL,MADRID,SPAIN. HOSP UNIV SAN CARLOS,SERV CIRUGIA,MADRID,SPAIN.
authors.forename: P
authors.initials: P
authors.lastname: Iniesta
authors.forename: T
authors.initials: T
authors.lastname: Caldes
authors.forename: F
authors.initials: F
authors.lastname: Vega
authors.forename: J
authors.initials: J
authors.lastname: Lopez
authors.forename: E
authors.initials: E
authors.lastname: Diazrubio
authors.forename: J
authors.initials: J
authors.lastname: Cerdan
authors.forename: A
authors.initials: A
authors.lastname: Torres
authors.forename: J
authors.initials: J
authors.lastname: Balibrea
authors.forename: M
authors.initials: M
authors.lastname: Benito