title: Correlation of pulsatility index with intracranial pressure in traumatic brain injury.
abstract: OBJECTIVE
  In traumatic brain injury (TBI) patients, it is desired to monitor the intracranial pressure (ICP) to assess the cerebral haemodynamics and guide the therapy. The study was designed to see if the pulsatility index (PI) measured by transcranial Doppler ultrasonography (TCD) predicts information about ICP values.
  
  
  METHODS
  In 52 TBI patients with Glasgow Coma Scale (GCS) score < 9, invasive intracranial monitoring and TCD ultrasonography for PI were performed through five days. ICP, cerebral perfusion pressure (CPP), PI values were recorded and calculated. The correlation and regression analysis between ICP, PI and CPP were investigated in the whole group and in patients with a Glasgow Outcome Score (GOS) of 3-5.
  
  
  RESULTS
  The decline in ICP and PI values was significant through five days. The correlation between ICP and PI was strongly significant (p < 0.0001) on days 1, 3 and 5. In patients with a GOS of 3-5, correlation of ICP and PI was also observed. The only significant correlation observed between CPP and PI was on day 5.
  
  
  CONCLUSIONS
  The strong correlation observed between ICP and PI through the management period of TBI patients can lead us to use TCD ultrasonography-derived PI as a guide if invasive monitoring is not available.
authors.affiliation: Goztepe Training Hospital, Department of Anesthesiology and Reanimation, Istanbul, Turkey. melekgura@gmail.com
authors.forename: Melek
authors.initials: M
authors.lastname: Gura
authors.forename: Ilhan
authors.initials: I
authors.lastname: Elmaci
authors.forename: Ramazan
authors.initials: R
authors.lastname: Sari
authors.forename: Nilufer
authors.initials: N
authors.lastname: Coskun
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000379:methods; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D019586:Intracranial Hypertension / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011673:Pulsatile Flow / Q000502:physiology*; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*; D055815:Young Adult