title: Acute effects of nicotine administration during prospective memory, an event related fMRI study.
abstract: We previously demonstrated that stimulating neuronal nicotinic acetylcholine receptors modulates prospective memory (PM), the ability to remember and implement a prior intention. Here we used fMRI to explore the neuronal correlates of acute nicotinic (1mg) modulation during PM, employing a double blind, valence-matched placebo-controlled design, and a solely event-related analysis. Eight healthy adults completed on two occasions (1 week washout) a simple attentional task containing infrequent PM trials. PM activated bilateral parietal, prefrontal (BA10) and anterior cingulate, and deactivated genual cingulate and medial prefrontal regions. Further, acute nicotine administration decreased activity within a largely overlapping right parietal region. This data validates a purely event-related approach to exploring PM, and suggests procholinergic modulation of PM by parietal rather than BA10/frontal regions.
authors.affiliation: School of Psychology, University of Sussex, Brighton, East Sussex BN1 9QG, United Kingdom. J.Rusted@sussex.ac.uk
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rusted
authors.forename: Torsten
authors.initials: T
authors.lastname: Ruest
authors.forename: Marcus A
authors.initials: MA
authors.lastname: Gray
mesh_terms: D000328:Adult; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D005071:Evoked Potentials / Q000187:drug effects*; D005260:Female; D006801:Humans; D033182:Intention; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000187:drug effects*; D061212:Memory, Episodic; D059085:Nasal Sprays; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D012016:Reference Values; D055815:Young Adult
chemical_list: D059085:Nasal Sprays; D018722:Nicotinic Agonists; D009538:Nicotine