title: Aspirin and aspirin-like drugs induce HLA-DR expression in HT29 colon cancer cells.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the incidence of colon cancer. The underexpression of HLA antigens during colon cancer development is suspected to be a mechanism by which malignant cells escape immune surveillance. We examined whether NSAIDs affect the expression of HLA-DR in HT29 human colon adenocarcinoma cells, which do not express HLA-DR. Aspirin, indomethacin and sulindac induced several-fold the expression of HLA-DR in these cells in a concentration- and time-dependent manner. Aspirin increased HLA-DR alpha steady-state mRNA levels and HLA-DR alpha gene transcription rate. These findings raise the possibility that such a mechanism may be operative in vivo.
authors.affiliation: CORNELL UNIV,COLL MED,DEPT MED,NEW YORK,NY 10021.
authors.forename: P
authors.initials: P
authors.lastname: Arvind
authors.forename: L
authors.initials: L
authors.lastname: Qiao
authors.forename: E
authors.initials: E
authors.lastname: Papavassiliou
authors.forename: E
authors.initials: E
authors.lastname: Goldin
authors.forename: M
authors.initials: M
authors.lastname: Koutsos
authors.forename: B
authors.initials: B
authors.lastname: Rigas