title: MicroRNA regulation constrains the organization of target genes on mammalian chromosomes.
abstract: The regulation of microRNAs (miRNAs) is a complicated process requiring a large number of molecular events to be coordinated in both space and time. It is not known whether this complicated regulation process constrains the organization of target genes on mammalian chromosomes. We performed a genome-wide analysis to provide a better picture of chromosomal organization of miRNA target genes. Our results showed clustering of the target genes (TGs) of miRNAs on mammalian chromosomes, and further revealed that the particular gene organization is constrained by miRNA regulation. The clustering pattern of TGs provides an insight into the complexity of miRNA regulation.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, PR China.
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Wang
authors.forename: Bin-Sheng
authors.initials: BS
authors.lastname: Gong
authors.forename: Hua-Kun
authors.initials: HK
authors.lastname: Wang
authors.forename: Hong-Jiu
authors.initials: HJ
authors.lastname: Wang
authors.forename: Meng
authors.initials: M
authors.lastname: Zhou
authors.forename: Qiang-Hu
authors.initials: QH
authors.lastname: Wang
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Xia
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000235:genetics*; D016000:Cluster Analysis; D005786:Gene Expression Regulation; D005796:Genes; D055106:Genome-Wide Association Study; D008322:Mammals; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs