title: Association of angiotensin I converting enzyme insertion/deletion polymorphism with breast cancer: a meta-analysis.
abstract: BACKGROUND
  Polymorphisms of angiotensin I converting enzyme (ACE) gene have been inconsistently associated with breast cancer risk. We examined these associations by performing a meta-analysis.
  
  
  METHODS
  Four studies (cases: 1422; controls: 3044) testing the association between ACE insertion/deletion (I/D) polymorphism and breast cancer were examined. The analyses were performed using the Review Manager 5.0.25 software package.
  
  
  RESULTS
  The combined results based on the above four studies showed that there was no significant difference in genotype distribution (DD, ID or II) between breast cancer patients and controls, with the odds ratio (OR) (1.00; 0.94; 1.11) and 95% confidence interval (CI) (0.76 to 1.33; 0.83 to 1.07; 0.96 to 1.28) for DD, ID and II genotype respectively.
  
  
  CONCLUSIONS
  The meta-analysis suggests that ACE I/D polymorphism may not be a genetic risk factor for breast cancer.
authors.affiliation: Jinan Central Hospital affiliated to Shandong University, Shandong, PR China.
authors.forename: Meili
authors.initials: M
authors.lastname: Sun
authors.forename: Chuanyong
authors.initials: C
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Wei
authors.forename: Jie
authors.initials: J
authors.lastname: Zhong
authors.forename: Yuping
authors.initials: Y
authors.lastname: Sun
mesh_terms: D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A