title: [Intestinal endotoxin in induction of type 1 diabetes].
abstract: We studied serum level of intestinal flora endotoxin (LPS) in 45 children and adolescents aged 3-17 years old with diabetes mellitus type 1. Levels of endotoxin, were significantly elevated in type 1 diabetic patients (2.89 +/- 0.33 Eu/ml) compared with control (0.4 +/- 0.03 Eu/ml). There was significant difference in serum LPS levels in patients with type 1 diabetes onset (3.93 +/- 0.79 Eu/ml) compared with children and adolescent with old time diabetes (2.37 +/- 0.27 Eu/ml). These results have a major implication on our understanding of the role of gut flora endotoxin in pathogenesis of type 1 diabetes.
authors.forename: P L
authors.initials: PL
authors.lastname: Okorokov
authors.forename: I A
authors.initials: IA
authors.lastname: Anikhovskaia
authors.forename: I E
authors.initials: IE
authors.lastname: Volkov
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Iakovlev
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D008070:Lipopolysaccharides / Q000097:blood* / Q000378:metabolism; D008297:Male
chemical_list: D008070:Lipopolysaccharides