title: The role of human leukocyte antigen and tumor necrosis factor D as a prognostic, preventive and therapeutic factor in gastric cancer.
abstract: In order to clarify the immunogenetical background, host factors in oncology, human leukocyte antigen (HLA) and tumor necrosis factor (TNF) beta alleles as prognostic, preventive and therapeutic indicators were investigated in 712 patients with a histologic diagnosis of adenocarcinoma of the stomach treated with gastrectomy. HLA and TNF beta alleles were tested serologically and by DNA-PCR typing. The absence of HLA Cw1 antigen may represent resistant and prognostic factors. HLA-B51, B61 and TNF beta 10.5 kb homozygote alleles are therapeutic, survival and prognostic factors. Considering the relation with lymph node metastasis, HLA-DR4 antigen and HLA-DRB 1*0405 allele were found to be risk factors for lymph node metastasis in poorly differentiated adenocarcinoma. TNF beta 10.5 kb homozygote allele also represented a risk factor for lymph node metastasis. TNF beta 5.5 kb homozygote allele was considered a resistant factor for lymph node metastasis in poorly differentiated adenocarcinoma. HLA and TNF beta alleles can play an important role as prognostic, preventive and therapeutic indicators in gastric cancer. Therefore, TNMH (TNM with host factor) should be proposed as a new approach.
authors.affiliation: TOKAI UNIV,SCH MED,DEPT SURG,ISEHARA,KANAGAWA 25911,JAPAN. TOKYO MED COLL,DEPT SURG,SHINJUKU KU,TOKYO 160,JAPAN. CHIBA UNIV,SCH MED,DEPT SURG,CHIBA 280,JAPAN. GUNMA UNIV,SCH MED,DEPT SURG,MAEBASHI,GUMMA 371,JAPAN. KITASATO UNIV,SCH MED,DEPT IMMUNOL,SAGAMIHARA,KANAGAWA 228,JAPAN.
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
authors.forename: K
authors.initials: K
authors.lastname: Ogoshi
authors.forename: T
authors.initials: T
authors.lastname: Shimura
authors.forename: M
authors.initials: M
authors.lastname: Hagihara
authors.forename: K
authors.initials: K
authors.lastname: Isono
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Nagamachi
authors.forename: N
authors.initials: N
authors.lastname: Kashiwagi