title: Small nodular melanoma: the beginning of a life-threatening lesion. A clinical study on 11 cases.
abstract: OBJECTIVE
  Because of its high thickness, nodular melanoma often bears a poor prognosis. Thus, an earlier diagnosis of this type of lesion while it is still thin would be an important step in secondary prevention. The principal aim of the present study was to better define the initial clinical features of nodular melanoma to allow an early diagnosis. A secondary aim was to establish the prognosis of this type of lesion.
  
  
  METHODS
  We retrospectively studied and illustrated the clinical features of 11 small (< or = 6 mm maximum diameter) cutaneous nodular melanomas seen and treated during a 10-year period. Prognostic characteristics of the various lesions were also described.
  
  
  RESULTS
  The results of the study help to describe a small nodular melanoma as a dark and/or pink/red raised lesion, which may be evenly or unevenly colored, with well-defined borders, that often appears de novo. A correct clinical diagnosis was made in 7 of the cases. During a median follow-up of 6 years, none of the patients had local or distant relapses.
  
  
  CONCLUSIONS
  Detection of small nodular melanoma is feasible by accurate visual inspection, provided that physicians are aware of this type of lesion and maintain the index of suspicion at a high level to bring about curative surgery.
authors.affiliation: Day Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy. aldo.bono@istitutotumori.mi.it
authors.forename: Aldo
authors.initials: A
authors.lastname: Bono
authors.forename: Elena
authors.initials: E
authors.lastname: Tolomio
authors.forename: Antonino
authors.initials: A
authors.lastname: Carbone
authors.forename: Daniele
authors.initials: D
authors.lastname: Moglia
authors.forename: Federica
authors.initials: F
authors.lastname: Crippa
authors.forename: Stefano
authors.initials: S
authors.lastname: Tomatis
authors.forename: Mario
authors.initials: M
authors.lastname: Santinami
mesh_terms: D000328:Adult; D000368:Aged; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D010808:Physical Examination; D011379:Prognosis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology