title: New roles for lysosomal trafficking in morphogen gradient sensing.
abstract: The way in which cells recognize their position in a gradient of morphogen controls differentiation during embryogenesis. New findings indicate that the rate at which internalized morphogen receptors are trafficked to lysosomes is key to the accurate and precise sensing of morphogen gradients and the appropriate initiation of differentiation programs during development.
authors.affiliation: Integrin Cell Biology Laboratory, Beatson Institute for Cancer Research, Bearsden, Glasgow G611BD, Scotland, UK.
authors.forename: Elena
authors.initials: E
authors.lastname: Rainero
authors.forename: Jim C
authors.initials: JC
authors.lastname: Norman
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*