title: Determination of pharmaceutical and personal care products in wastewater by capillary electrophoresis with UV detection.
abstract: Capillary electrophoresis (CE) offers a fast and cost-effective alternative analytical technique to LC-MS/MS for separation and quantitation of many PPCP compounds in wastewater. In this study, we have developed a method that can simultaneously analyze eight different PPCP compounds in untreated wastewater (ibuprofen, triclosan, carbamazepine, caffeine, acetaminophen, sulfamethoxazole, trimethoprim, and lincomycin), using capillary electrophoresis with UV detection (CE-UV). The method detection limit (MDL) ranged from 1.6 to 68.7 ppb through solid phase extraction. The standard limit of quantification (LOQ) ranged from 0.63 to 7.72 ppm. Factors affecting separation and quantification of PPCPs, such as pH, electrophoretic potential, buffer strength, buffer type, and additives, were investigated and optimized. Water samples from two different wastewater treatment plants were collected and analyzed. The results obtained were comparable with those of LC-MS/MS. The technique developed in this study provides a low cost, simple, fast, and relatively sensitive method for determination of various PPCPs in wastewater samples for PPCP screening.
authors.affiliation: Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, 400 West 11th Street, Rolla, MO 65409, USA.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Gibbons
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.forename: Yinfa
authors.initials: Y
authors.lastname: Ma
mesh_terms: D053000:Analytic Sample Preparation Methods; D002021:Buffers; D003358:Cosmetics / Q000032:analysis* / Q000302:isolation & purification; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007267:Injections; D057230:Limit of Detection; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000302:isolation & purification; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D014865:Waste Disposal, Fluid; D014867:Water / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000302:isolation & purification
chemical_list: D002021:Buffers; D003358:Cosmetics; D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical; D014867:Water