title: Kidney function tests in children with beta-thalassemia minor in Zahedan, southeast of Iran.
abstract: There is little information regarding kidney function in patients with beta-thalassemia minor. In this study we investigated kidney function tests in 50 children with beta-thalassemia minor (22 boys and 28 girls). Twenty-four-hour urine samples were collected and analyzed for sodium, potassium, calcium, magnesium, creatinine, phosphate, uric acid, protein, and beta2-microglobulin. Blood samples were obtained for hematologic and biochemical analyses including complete blood count, serum ferritin, sodium, potassium, calcium, phosphate, magnesium, creatinine, and uric acid. This group of children with beta-thalassemia showed some evidence of tubulopathy such as proteinuria (32%), beta2-microglobulin excretion (36%), calciuria (4%), phosphaturia (4%), and uricosuria (20%). Our findings support the existence of renal tubular dysfunction in beta-thalassemia minor. However, further studies in large series are needed to shed light on the possible relation of these two distinct diseases.
authors.affiliation: Department of Pediatrics, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. sisadegh@yahoo.com
authors.forename: Simin
authors.initials: S
authors.lastname: Sadeghi-Bojd
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.forename: Majid
authors.initials: M
authors.lastname: Naderi
authors.forename: Shahriar
authors.initials: S
authors.lastname: Shikhani
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D007677:Kidney Function Tests / Q000379:methods*; D007684:Kidney Tubules / Q000503:physiopathology; D008297:Male; D011507:Proteinuria / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood; D055815:Young Adult; D001613:beta 2-Microglobulin / Q000097:blood; D017086:beta-Thalassemia / Q000150:complications / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D001613:beta 2-Microglobulin; D014527:Uric Acid; D003404:Creatinine