title: Stimulation of muscle protein synthesis by whey and caseinate ingestion after resistance exercise in elderly individuals.
abstract: Sarcopenia is a well-known phenomenon in elderly individuals and resistance exercise together with sufficient amino acid (AA) availability has proved to be a counteractive implement. However, the source of AA and supplement timing require further investigation. The objective was to compare muscle protein synthesis (MPS) to intakes of whey and caseinate after heavy resistance exercise in healthy elderly individuals, and, furthermore, to compare the timing effect of caseinate intake. Twenty-four elderly men and women (mean ± SEM; 68 ± 1 years) were randomized to one of four groups: caseinate intake before exercise (CasPre), caseinate intake immediately after exercise (CasPost), whey intake immediately after exercise (Whey), or intake of a non-caloric control drink (Control). Muscle myofibrillar and collagen fractional synthesis rates (FSR) were measured by a primed continuous infusion of L-[1-(13) C]leucine using labeled proteins during a 6-h recovery period. No differences were observed in muscle myofibrillar and collagen FSR with Whey (0.09 ± 0.01%/h) compared with CasPost (0.09 ± 0.003%/h), and it did not differ between CasPre (0.10 ± 0.01%/h) and CasPost. MPS does not differ with whey and caseinate feeding immediately after heavy resistance exercise in elderly individuals, and MPS is similar with caseinate ingestion before and after exercise.
authors.affiliation: Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen, M. Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. kasperjuel@hotmail.com
authors.forename: K J
authors.initials: KJ
authors.lastname: Dideriksen
authors.forename: S
authors.initials: S
authors.lastname: Reitelseder
authors.forename: S G
authors.initials: SG
authors.lastname: Petersen
authors.forename: M
authors.initials: M
authors.lastname: Hjort
authors.forename: I C
authors.initials: IC
authors.lastname: Helmark
authors.forename: M
authors.initials: M
authors.lastname: Kjaer
authors.forename: L
authors.initials: L
authors.lastname: Holm
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002364:Caseins / Q000008:administration & dosage / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008894:Milk Proteins / Q000008:administration & dosage / Q000378:metabolism*; D024510:Muscle Development / Q000502:physiology; D009124:Muscle Proteins / Q000096:biosynthesis*; D055070:Resistance Training; D000067816:Whey Proteins
chemical_list: D002364:Caseins; D004044:Dietary Proteins; D008894:Milk Proteins; D009124:Muscle Proteins; D000067816:Whey Proteins; D003094:Collagen