title: New agents for prevention of ultraviolet-induced nonmelanoma skin cancer.
abstract: With the incidence of nonmelanoma skin cancer on the rise, current prevention methods, such as the use of sunscreens, have yet to prove adequate to reverse this trend. There has been considerable interest in identifying compounds that will inhibit or reverse the biochemical changes required for skin cancers to develop, either by pharmacologic intervention or by dietary manipulation. By targeting different pathways identified as important in the pathogenesis of nonmelanoma skin cancers, a combination approach with multiple agents or the addition of chemopreventative agents to topical sunscreens may offer the potential for novel and synergistic therapies in treating nonmelanoma skin cancer.
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors.forename: William L
authors.initials: WL
authors.lastname: Camp
authors.forename: Jennifer W
authors.initials: JW
authors.lastname: Turnham
authors.forename: Mohammad
authors.initials: M
authors.lastname: Athar
authors.forename: Craig A
authors.initials: CA
authors.lastname: Elmets
mesh_terms: D000813:Anilides / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D002338:Carotenoids / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D045643:DNA Repair Enzymes / Q000627:therapeutic use; D018752:Diet, Fat-Restricted; D000518:Eflornithine / Q000627:therapeutic use; D005419:Flavonoids / Q000627:therapeutic use; D019833:Genistein / Q000627:therapeutic use; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D000077276:Lycopene; D010636:Phenols / Q000627:therapeutic use; D010778:Photochemotherapy; D059808:Polyphenols; D011725:Pyridines / Q000627:therapeutic use; D012176:Retinoids / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D013473:Sunscreening Agents / Q000627:therapeutic use; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D000813:Anilides; D052246:Cyclooxygenase 2 Inhibitors; D005419:Flavonoids; C538724:HhAntag691; D010636:Phenols; D059808:Polyphenols; D011725:Pyridines; D012176:Retinoids; D013473:Sunscreening Agents; D002338:Carotenoids; D019833:Genistein; D045643:DNA Repair Enzymes; D000077276:Lycopene; D000518:Eflornithine