title: Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma.
abstract: The purpose of this study was to assess the properties of CD4+CD25(high/low/negative) T cell subsets and analyze their relation with dendritic cells (DCs) in patients with hepatocellular carcinoma (HCC). In HCC patients, the prevalence of CD45RO+ cells in CD4+CD25(high) T cells was increased and associated with higher frequencies of plasmacytoid DCs. Larger proportions of this T cell subset were detected in the patients with larger tumor burdens. These results suggest that increased frequencies of the CD45RO+ subset in CD4+CD25(high) Tregs in HCC patients may establish the immunosuppressive environment cooperatively with tolerogenic plasmacytoid DCs to promote disease progression of liver cancer.
authors.affiliation: Disease Control and Homeostasis, Graduate School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Takata
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Nakamoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Terashima
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Arihara
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kitahara
authors.forename: Kaheita
authors.initials: K
authors.lastname: Kakinoki
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Arai
authors.forename: Taro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Sakai
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamashita
authors.forename: Eishiro
authors.initials: E
authors.lastname: Mizukoshi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kaneko
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000276:immunology* / Q000473:pathology; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D017493:Leukocyte Common Antigens / Q000276:immunology*; D008113:Liver Neoplasms / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D017493:Leukocyte Common Antigens