title: Modulation of cisplatin sensitivity and resistance by buthionine sulfoximine and cyclosporin A in human esophageal cancer cells.
abstract: We established a 2.4-fold cisplatin (CDDP)-resistant human esophageal cancer cell line (TE2R) from the parent TE2 line. CDDP accumulation was reduced in TE2R. The Na+, K+-ATPase inhibitor ouabain inhibited CDDP accumulation in TE2 but not TE2R, suggesting that TE2R may have alterations in the Na+, K+-ATPase and defective CDDP uptake mechanism. Buthionine sulfoximine (BSO) enhanced CDDP sensitivity of both cell lines and cyclosporin A (CsA) modified CDDP resistance in TE2R. These effects were associated with increased CDDP accumulation. Thus, BSO and CsA may be useful for modulation of CDDP sensitivity or resistance in esophageal cancer.
authors.affiliation: NIIGATA CITY GEN HOSP,DEPT SURG 1,NIIGATA 950,JAPAN. NIIGATA CANC CTR HOSP,DIV SURG,NIIGATA 951,JAPAN.
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Aizawa
authors.forename: N
authors.initials: N
authors.lastname: Katayanagi
authors.forename: H
authors.initials: H
authors.lastname: Yabusaki
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: O
authors.initials: O
authors.lastname: Tanaka