title: Granulocyte-colony stimulating factor protects memory impairment in the senescence-accelerated mouse (SAM)-P10.
abstract: OBJECTIVE
  Alzheimer's disease (AD) is a progressive neurodegenerative disorder with memory impairment in elderly people. At present, AD remains incurable. More and more evidences have suggested that granulocyte-colony stimulating factor (G-CSF) has important non-hematopoietic neuroprotective functions in central nervous system. The present study was designed to investigate the therapeutic potential of G-CSF in the senescence-accelerated mouse prone strain (SAM-P10) mice, a mouse model of senile dementia.
  
  
  METHODS
  Recombinant human G-CSF was administered subcutaneously in SAM-P10 mice once daily for consecutive 7 days. Morris water maze test was used to evaluate spatial memory of the mice. Immunohistochemistry analysis was done to elucidate the changes of apoptotic neurons in CA1 region of hippocampus of the mice.
  
  
  RESULTS
  In the present study, we found that administration of recombinant G-CSF significantly protected spatial memory impairment, and decreased the number of apoptotic (caspase-3-positive) and tumor necrosis factor related apoptosis-inducing ligand (TRAIL)-positive neurons in CA1 region of hippocampus of SAM-P10 mice, suggesting that G-CSF may protect spatial memory impairment through suppression of TRAIL-mediated apoptosis in neurons.
  
  
  CONCLUSIONS
  These findings highlight the therapeutic potential of G-CSF in AD.
authors.affiliation: Department of Neurology, The Second Hospital of Shandong University, Jinan, China. bjz@sdu.edu.cn
authors.forename: Cuiping
authors.initials: C
authors.lastname: Zhao
authors.forename: Zhaohong
authors.initials: Z
authors.lastname: Xie
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Lai
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Zhu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Cong
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Chengyun
authors.initials: C
authors.lastname: Zheng
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Bi
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents; D011993:Recombinant Fusion Proteins; D016179:Granulocyte Colony-Stimulating Factor