title: Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas.
abstract: OBJECTIVE
  To investigate the role of glucose transporter 1 (GLUT1) expression in colorectal carcinogenesis and evaluate the correlation with clinicopathological parameters and apoptosis-activating factor-1 (Apaf-1) expression in colorectal adenocarcinomas.
  
  
  METHODS
  We used tissue microarrays consisting of 26 normal mucosa, 50 adenomas, 515 adenocarcinomas, and 127 metastatic lesions. Medical records were reviewed and clinicopathological analysis was performed.
  
  
  RESULTS
  GLUT1 expression was absent in normal mucosa and low or moderately apparent in 19 cases (38.0%) of 50 adenomas. However, GLUT1 expression was detected in 423 (82.1%) of 515 adenocarcinomas and in 96 (75.6%) of 127 metastatic lesions. GLUT1 expression was significantly correlated with female gender (P = 0.009), non-mucinous tumor type (P = 0.045), poorer differentiation (P = 0.001), lymph node metastasis (P < 0.001), higher AJCC and Dukes stage (P < 0.001 and P < 0.001, respectively). There was a significant inverse correlation between GLUT1 expression and Apaf-1 expression (P = 0.001). In univariate survival analysis, patients with GLUT1 expression demonstrated poor overall survival and disease-free survival (P = 0.047 and P = 0.021, respectively, log-rank test).
  
  
  CONCLUSIONS
  GLUT1 expression was frequently increased in adenocarcinomas and metastatic lesions. GLUT1 expression was significantly correlated with poorer clinicopathologic phenotypes and survival of patients with colorectal adenocarcinomas.
authors.affiliation: Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, South Korea.
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Jun
authors.forename: Se Min
authors.initials: SM
authors.lastname: Jang
authors.forename: Hu Lin
authors.initials: HL
authors.lastname: Han
authors.forename: Kang Hong
authors.initials: KH
authors.lastname: Lee
authors.forename: Ki-Seok
authors.initials: KS
authors.lastname: Jang
authors.forename: Seung Sam
authors.initials: SS
authors.lastname: Paik
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D053477:Apoptotic Protease-Activating Factor 1 / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D046888:Tissue Array Analysis
chemical_list: D053477:Apoptotic Protease-Activating Factor 1; D051272:Glucose Transporter Type 1; C495677:SLC2A1 protein, human