title: Genital HSV detection among HIV-1-infected pregnant women in labor.
abstract: OBJECTIVE
  To compare genital HSV shedding among HIV-positive and HIV-negative women.
  
  
  METHODS
  Women with and without known HIV infection who delivered at the University of Washington Medical Center between 1989-1996 had HSV serologies done as part of clinical care. Genital swabs from HSV-2-seropositive women were evaluated by real-time quantitative HSV DNA PCR.
  
  
  RESULTS
  HSV-2 seroprevalence was 71% and 30% among 75 HIV-positive and 3051 HIV-negative women, respectively, (P < .001). HSV was detected at delivery in the genital tract of 30.8% of HIV-seropositive versus 9.5% of HIV-negative women (RR = 3.2, 95% CI 1.6 to 6.5, P = .001). The number of virion copies shed per mL was similar (log 3.54 for HIV positive versus 3.90 for HIV negative, P = .99).
  
  
  CONCLUSIONS
  Our study demonstrated that HIV-, HSV-2-coinfected women are more likely to shed HSV at delivery.
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195-6320, USA. jannapat@uw.edu
authors.forename: Janna
authors.initials: J
authors.lastname: Patterson
authors.forename: Jane
authors.initials: J
authors.lastname: Hitti
authors.forename: Stacy
authors.initials: S
authors.lastname: Selke
authors.forename: Meei-Li
authors.initials: ML
authors.lastname: Huang
authors.forename: D Heather
authors.initials: DH
authors.lastname: Watts
authors.forename: Zane
authors.initials: Z
authors.lastname: Brown
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: Anna
authors.initials: A
authors.lastname: Wald
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000821:virology*; D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005836:Genitalia, Female / Q000821:virology; D006558:Herpes Genitalis / Q000821:virology*; D018258:Herpesvirus 2, Human / Q000302:isolation & purification*; D006801:Humans; D007743:Labor, Obstetric; D008875:Middle Aged; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D017201:Virus Shedding