title: A randomized, double-blind trial of transcranial electrostimulation in early Parkinson's disease.
abstract: We studied the effects of noninvasive transcranial electrical stimulation on the motor and psychological symptoms of early Parkinson's disease. Twenty-three subjects were treated with 10 days of placebo versus active treatment and then followed for 14 weeks. Baseline off medication Unified Parkinson's Disease Rating Scale parts I-III was 29.4 ± 10.0. The primary end point, Unified Parkinson's Disease Rating Scale in week 2 following treatment, reduced by 5.3 ± 9.7 for those in active treatment and 7.7 ± 4.8 for those receiving placebo (not significant). Similarly, no significant differences were seen in the Hamilton Anxiety Scale, Geriatric Depression Scale, and Epworth Sleepiness Scale over the duration of the study. The treatment was well tolerated without device-related adverse events. Despite the negative study, nonpharmacological approaches should continue to be pursued in Parkinson's disease, as they are generally well received by patients.
authors.affiliation: Banner Sun Health Research Institute, Sun City, Arizona, USA. Holly.shill@bannerhealth.com
authors.forename: Holly A
authors.initials: HA
authors.lastname: Shill
authors.forename: Sanja
authors.initials: S
authors.lastname: Obradov
authors.forename: Yakov
authors.initials: Y
authors.lastname: Katsnelson
authors.forename: Ray
authors.initials: R
authors.lastname: Pizinger
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000628:therapy*; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D013997:Time Factors