title: Relationships among the serum omega fatty acid levels, serum C-reactive protein levels and arterial stiffness/wave reflection in Japanese men.
abstract: OBJECTIVE
  We examined the relationship among the serum omega-3 and omega-6 fatty acid (O3FA and O6FA) levels, serum C-reactive protein (CRP) levels, and arterial stiffness/wave reflection (AS/WR) in healthy Japanese men.
  
  
  METHODS
  In 2206 Japanese healthy men, parameters related to the AS/WR (i.e., brachial-ankle pulse wave velocity and radial arterial pulse wave analysis) were measured.
  
  
  RESULTS
  No significant inverse relationships were observed between the serum O3FA levels and the AS/WR-related parameters. Adjusted values of the AS/WR-related parameters and serum CRP levels were higher in the subjects with serum O6FA levels in the highest tertile than in those with serum O6FA levels in the lowest tertile.
  
  
  CONCLUSIONS
  In healthy Japanese men with known high dietary intakes of O3FAs, the serum O3FA levels may not reflect the pathophysiological abnormalities related to AS/WR. Increased serum O6FA levels appeared to be independently associated with the unfavorable conditions related to AS/WR and inflammation.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Tokyo, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tomiyama
authors.forename: Chisa
authors.initials: C
authors.lastname: Matsumoto
authors.forename: Mari
authors.initials: M
authors.lastname: Odaira
authors.forename: Jiko
authors.initials: J
authors.lastname: Yamada
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yoshida
authors.forename: Kazuki
authors.initials: K
authors.lastname: Shiina
authors.forename: Mikio
authors.initials: M
authors.lastname: Nagata
authors.forename: Akira
authors.initials: A
authors.lastname: Yamashina
mesh_terms: D000328:Adult; D055109:Ankle Brachial Index; D044466:Asian People / Q000706:statistics & numerical data; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000032:analysis*; D003187:Compliance; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000208:ethnology / Q000276:immunology / Q000503:physiopathology; D007564:Japan; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood / Q000208:ethnology / Q000276:immunology / Q000503:physiopathology; D011673:Pulsatile Flow; D017534:Radial Artery / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D002097:C-Reactive Protein