title: Aspergillus fumigatus infection as a delayed manifestation of prosthetic knee arthroplasty and a review of the literature.
abstract: Fungal infection after total joint arthroplasty is a very rare but serious complication and a challenge to the treating and consulting physicians. The literature includes little information about the treatment protocol for Aspergillus infection after total knee arthroplasty, since only 3 cases have been reported. We describe the case of a non-immunocompromised patient who lacked predisposing risk factors and presented with pain and swelling. An aspiration under sterile conditions revealed Aspergillus fumigatus. The patient was treated successfully with a 2-stage exchange reimplantation and 6-week course of liposomal amphotericin B. At 4 y after reimplantation, the patient had no evidence of infection or pain.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Istanbul Medipol University, Istanbul, Turkey. myilmaz@medipol.edu.tr
authors.forename: Mesut
authors.initials: M
authors.lastname: Yilmaz
authors.forename: Bilgül
authors.initials: B
authors.lastname: Mete
authors.forename: Reşat
authors.initials: R
authors.lastname: Ozaras
authors.forename: Gökhan
authors.initials: G
authors.lastname: Kaynak
authors.forename: Fehmi
authors.initials: F
authors.lastname: Tabak
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Tenekecioğlu
authors.forename: Recep
authors.initials: R
authors.lastname: Oztürk
mesh_terms: D000369:Aged, 80 and over; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D001232:Aspergillus fumigatus; D006801:Humans; D007717:Knee / Q000382:microbiology*; D007720:Knee Prosthesis; D008297:Male; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B