title: Impact of vertical banded gastroplasty on body weight, insulin resistance, adipocytokine, inflammation and metabolic syndrome markers in morbidly obese patients.
abstract: BACKGROUND
  Diet, exercise, and pharmacological therapy have been shown to be unsatisfactory treatments for severe obesity in the long term. Bariatric surgery is the most effective means to achieve weight loss in morbidly obese subjects. The aim of this study was to evaluate the action of a number of adipocytokines, as well as the metabolic syndrome parameters of obese patients, before and after vertical banded gastroplasty (VBG).
  
  
  METHODS
  The test subjects comprised eight males and 20 females (total 28 patients) aged from 20 to 59 years (43.7 ± 10.0) with simple obesity and the presence of metabolic syndrome, both before and 3, 6, 12, and 24 months after bariatric surgery (six patients were also checked after 36 and 48 months).
  
  
  RESULTS
  After surgical treatment (at 24 months), the values of body weight, BMI, waist circumference, blood pressure (RR-S, RR-D), HOMA-IR and blood concentrations of CRP, TG, IRI, AUC-IRI, and AUC-GLU gradually decreased. We did not observe any significant differences of fasting glucose, leptin, total cholesterol and LDL-cholesterol concentrations before or after surgery. The blood levels of HDL, adiponectin, resistin, and ghrelin gradually increased after treatment.
  
  
  CONCLUSIONS
  The significant decrease of body weight after vertical banded gastroplasty, as well as improvement of the main metabolic syndrome parameters and some adipocytokine blood levels, indicate the use of bariatric surgery as a valuable method of treating morbidly obese patients.
authors.affiliation: Department of Clinical Endocrinology, First Chair of Endocrinology, Medical University, Łódź, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Jankiewicz-Wika
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kołomecki
authors.forename: Jacek
authors.initials: J
authors.lastname: Cywiński
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Piestrzeniewicz
authors.forename: Jacek
authors.initials: J
authors.lastname: Swiętosławski
authors.forename: Henryk
authors.initials: H
authors.lastname: Stępień
authors.forename: Jan
authors.initials: J
authors.lastname: Komorowski
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D050110:Bariatric Surgery; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D005260:Female; D015391:Gastroplasty / Q000379:methods*; D054439:Ghrelin / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D054392:Adipokines; D054439:Ghrelin