title: Coverage and performance of colorectal cancer screening with the faecal occult blood test in Finland.
abstract: BACKGROUND
  Mortality from colorectal cancer has been shown to decrease by repeated screening using faecal occult blood (FOB) testing in randomized screening trials. This report presents coverage and performance of organized screening among the general population in Finland.
  
  
  METHODS
  In 2004-2007, people aged 60-69 years were randomized into biennial screening and control arms. The screening test was a guaiac-based FOB test (Hemoccult) with dietary restriction and three test cards for six consecutive samples. Test positives were referred for full colonoscopy. The programme was launched in 2004 and subsequently it expanded over regions and age-cohorts.
  
  
  RESULTS
  In 2007, the programme covered one-third of the target population and 74,592 people had been invited for screening, of them 26,866 for the second round. Uptakes for the first and second rounds, respectively, were 62% and 68% in men and 77% and 80% in women. The proportion of test positives increased from 2.4% to 2.9% from the first to the second round and the positive predictive value for cancers decreased from 7.5% to 4.3%.
  
  
  CONCLUSIONS
  By 2007, organized colorectal cancer screening covered one-third of the target population in Finland. Implementation of screening measured with response rate was successful and met the criteria for a public health programme, but performance in terms of positive predictive value needs monitoring.
authors.affiliation: Finnish Cancer Registry, Pieni Roobertinkatu 9, FIN-00130 Helsinki, Finland. nea.malila@cancer.fi
authors.forename: Nea
authors.initials: N
authors.lastname: Malila
authors.forename: Tiina
authors.initials: T
authors.lastname: Palva
authors.forename: Outi
authors.initials: O
authors.lastname: Malminiemi
authors.forename: Hannu
authors.initials: H
authors.lastname: Paimela
authors.forename: Ahti
authors.initials: A
authors.lastname: Anttila
authors.forename: Timo
authors.initials: T
authors.lastname: Hakulinen
authors.forename: Heikki
authors.initials: H
authors.lastname: Järvinen
authors.forename: Marja-Liisa
authors.initials: ML
authors.lastname: Kotisaari
authors.forename: Pekka
authors.initials: P
authors.lastname: Pikkarainen
authors.forename: Matti
authors.initials: M
authors.lastname: Rautalahti
authors.forename: Risto
authors.initials: R
authors.lastname: Sankila
authors.forename: Harri
authors.initials: H
authors.lastname: Vertio
authors.forename: Matti
authors.initials: M
authors.lastname: Hakama
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D005243:Feces; D005260:Female; D005387:Finland; D006801:Humans; D008297:Male; D008875:Middle Aged; D009780:Occult Blood