title: Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population.
abstract: Cytokines such as interleukin 10 (IL10) may play an important role in the process of inflammation. The aim of this study was to analyze the association between IL10, IL10RA and IL10RB single nucleotide polymorphisms (SNPs), and benign prostate hyperplasia (BPH) in Korean population. All patients with BPH were divided into two groups according to international prostate symptom score (IPSS), prostate specific antigen (PSA) level, Q(max), and prostate volume. We selected two IL10 SNPs (rs1518111 and rs1554286), three IL10RA SNPs (rs2256111, rs4252243, and rs2228054), and two IL10RB SNPs (rs999788 and rs2834167). Genotypes of seven SNPs were determined through direct sequencing. The G/G genotype of IL10RB polymorphism (rs2834167) was associated with a high PSA level compared with the A/G + A/A genotypes (P = 0.009). Of IL10 SNP, the A/A genotype of rs1518111 and T/T genotype of rs1554286 were associated with small prostate volume, respectively (P = 0.011, P = 0.014). Moreover, the T/T genotype of IL10RB polymorphism (rs999788) was associated with high prostatic volume compared with the T/C + C/C genotypes (P = 0.033). The linkage disequilibrium (LD) blocks were formed in IL10 and IL10RA. However, haplotypes in the LD block were not associated with BPH. It is concluded that there is a strong association between the IL10 and IL10RB SNPs, and BPH in Korean population.
authors.affiliation: Department of Urology, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Koo Han
authors.initials: KH
authors.lastname: Yoo
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Sung-Goo
authors.initials: SG
authors.lastname: Chang
mesh_terms: D000368:Aged; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007249:Inflammation; D016753:Interleukin-10 / Q000235:genetics*; D053709:Interleukin-10 Receptor alpha Subunit / Q000235:genetics*; D053710:Interleukin-10 Receptor beta Subunit / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017430:Prostate-Specific Antigen / Q000097:blood / Q000235:genetics; D011470:Prostatic Hyperplasia / Q000235:genetics*; D056910:Republic of Korea; D017422:Sequence Analysis, DNA
chemical_list: C508609:IL10 protein, human; D053709:Interleukin-10 Receptor alpha Subunit; D053710:Interleukin-10 Receptor beta Subunit; D016753:Interleukin-10; D017430:Prostate-Specific Antigen