title: Expression of a tumor-suppressor gene and of various protooncogenes in human and murine adriamycin-resistant and sensitive cell-lines.
abstract: Besides established mechanisms involved in cellular drug resistance including P-glycoprotein overexpression, topoisomerase alterations and xenobiotic detoxification, the hypothesis that proto-oncogene activation might also play a role in cell resistance has been postulated. This hypothesis has been tested by comparing the expression of various proto-oncogenes involved in signal transduction pathways (c-H-ras, c-g-ras, c-mil, c-myc, c-myb, c-fos), as well as the mdr gene and a tumor suppressor gene (p53) in different adriamycin-resistant (acquired or de novo) or sensitive cell lines, The implication of these variations in the process of chemoresistance is discussed.
authors.affiliation: INST CANC RES LILLE,INSERM,U124,F-59045 LILLE,FRANCE.
authors.forename: N
authors.initials: N
authors.lastname: Mestdagh
authors.forename: D
authors.initials: D
authors.lastname: Lantoine
authors.forename: M
authors.initials: M
authors.lastname: Dhooghe
authors.forename: J
authors.initials: J
authors.lastname: Henichart