title: Regulating the transition from centriole to basal body.
abstract: The role of centrioles changes as a function of the cell cycle. Centrioles promote formation of spindle poles in mitosis and act as basal bodies to assemble primary cilia in interphase. Stringent regulations govern conversion between these two states. Although the molecular mechanisms have not been fully elucidated, recent findings have begun to shed light on pathways that regulate the conversion of centrioles to basal bodies and vice versa. Emerging studies also provide insights into how defects in the balance between centrosome and cilia function could promote ciliopathies and cancer.
authors.affiliation: Department of Pathology, School of Medicine, New York University Cancer Institute, New York, NY 10016, USA.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Brian D
authors.initials: BD
authors.lastname: Dynlacht
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002502:Centrioles / Q000648:ultrastructure*; D018385:Centrosome / Q000378:metabolism; D002923:Cilia / Q000378:metabolism*; D016193:G1 Phase; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000473:pathology; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D008938:Mitosis; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000473:pathology