title: Masquelet technique for the treatment of bone defects: tips-tricks and future directions.
abstract: Reconstruction of diaphyseal bone defects still represents a major clinical challenge. Several approaches are used with the common objective to regenerate bone loss and restore function. The methods most commonly used are the vascularised fibula autograft and the Ilizarov bone transfer technique. Recently, Masquelet proposed a procedure combining induced membranes and cancellous autografts. The aim of this article was to briefly describe the technique, to review the current evidence and to discuss the tips and tricks that could help the surgeons to improve outcome. Future directions to increase its effectiveness and expand its application are also being discussed. However, predicting the outcome of reconstruction of bone defects remains difficult; and the patient should always be informed that, although potential complications are mostly predictable, in most of the cases the reconstruction process is long and difficult.
authors.affiliation: Academic Department of Trauma and Orthopaedic Surgery, Leeds NIHR Biomedical Research Unit, Clarendon Wing, Floor A, Great George Street, Leeds General Infirmary, Leeds LS1 3EX, UK. pgiannoudi@aol.com
authors.forename: Peter V
authors.initials: PV
authors.lastname: Giannoudis
authors.forename: Omar
authors.initials: O
authors.lastname: Faour
authors.forename: Thomas
authors.initials: T
authors.lastname: Goff
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kanakaris
authors.forename: Rozalia
authors.initials: R
authors.lastname: Dimitriou
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000627:therapeutic use; D001861:Bone Regeneration / Q000502:physiology*; D016025:Bone Transplantation / Q000379:methods; D001842:Bone and Bones / Q000601:surgery*; D003646:Debridement / Q000379:methods; D018483:Diaphyses / Q000601:surgery; D019317:Evidence-Based Medicine; D006801:Humans; D019637:Orthopedic Procedures / Q000379:methods*; D013583:Synovial Membrane / Q000502:physiology*
chemical_list: D001843:Bone Cements