title: Maternal mental disorders and pregnancy outcomes: a clinical study in a Japanese population.
abstract: OBJECTIVE
  To assess the maternal and neonatal outcomes of pregnant women with mental disorders in Japan.
  
  
  METHODS
  We conducted this retrospective cohort study to examine the patients who delivered at Nagoya University Hospital (2005-2009). Thereafter, the patients without any complications other than mental disorders and with several sources of psychiatric information were included in the present series, and the maternal and neonatal outcomes between patients with or without maternal mental disorders were compared. The psychiatric outcomes and the adverse effects of psychotropic drugs were also examined.
  
  
  RESULTS
  A total of 1649 women delivered during this period, and 63 of them were complicated by maternal mental disorders. After the selection of patients for comparison purposes, women with mental disorders (n = 51) had a slightly but significantly shorter gestational age (39.2 ± 0.2 vs 39.8 ± 0.1 weeks, P = 0.003) and smaller birth weight (2993.0 ± 56.7 vs 3152.4 ± 23.6 g, P = 0.010) compared with the control group (n = 278). Intervention by psychiatrists was required for only 10 patients, and no patients required termination of pregnancy due to exacerbation of mental disorders. In schizophrenia patients who were taking atypical antipsychotics and benzodiazepine, a significant increase in maternal gestational weight gain, and a significant shorter gestational age were detected, respectively, compared with patients who were not receiving any drug treatments.
  
  
  CONCLUSIONS
  A trend towards a lower birth weight and shorter gestational age was observed in Japanese women with well-controlled mental disorders, but the effect of well-controlled mental disorders on the perinatal outcome was minimal.
authors.affiliation: Maternal and Perinatal Care Center, Nagoya University Hospital, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Masae
authors.initials: M
authors.lastname: Hironaka
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kotani
authors.forename: Seiji
authors.initials: S
authors.lastname: Sumigama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuda
authors.forename: Yukio
authors.initials: Y
authors.lastname: Mano
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Koji
authors.initials: K
authors.lastname: Tamakoshi
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kikkawa
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001724:Birth Weight / Q000187:drug effects; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007564:Japan; D001523:Mental Disorders / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000523:psychology; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000139:chemically induced*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D014150:Antipsychotic Agents