title: Enantioselective allylation of α,β-unsaturated aldehydes with allyltrichlorosilane catalyzed by METHOX.
abstract: α,β-Unsaturated aldehydes 6a-j undergo an enantioselective allylation with allylic trichlorosilanes 2a,b in the presence of METHOX (4) as a Lewis basic catalyst (≤10 mol %) to produce the homoallylic alcohols 7a-l at good to high enantioselectivity (83-96% ee). This study shows that the reactivity scope of METHOX can be extended from aromatic to nonaromatic aldehydes.
authors.affiliation: Department of Chemistry, WestChem, University of Glasgow, Glasgow, UK. a.malkov@lboro.ac.uk
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Malkov
authors.forename: Maciej
authors.initials: M
authors.lastname: Barłóg
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Jewkes
authors.forename: Jirí
authors.initials: J
authors.lastname: Mikusek
authors.forename: Pavel
authors.initials: P
authors.lastname: Kocovský