title: Increasing traffic on vascular routes.
abstract: The process of blood vessels formation and remodeling is highly regulated by a plethora of promoting and inhibiting signals that activate a large array of signaling cascades. The main molecular players of these signaling pathways are surface-localized receptors, which can transmit signals into the cytosol. Endocytosis and intracellular trafficking, by controlling protein receptor localization, distribution, and amount in space and time, can strongly impact on cell signaling outcomes. Recent work showed that, in vascular cells, integrin adhesive receptors undertake different intracellular routes, depending on their activation state, giving more complexity to the system. In addition, the endo-exocytic cycle of angiogenic growth factor receptors is also essential to integrate multiple signals and coordinate different cellular events.
authors.affiliation: Laboratory of Cell Adhesion Dynamics - IRCC and Department of Oncological Sciences, University of Torino School of Medicine, 10060 Candiolo, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Santambrogio
authors.forename: Donatella
authors.initials: D
authors.lastname: Valdembri
authors.forename: Guido
authors.initials: G
authors.lastname: Serini
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000502:physiology*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D016023:Integrins; D040301:Vascular Endothelial Growth Factor Receptor-2