title: Setting properties and biocompatibility of dicalcium silicate with varying additions of tricalcium aluminate.
abstract: This study sought to prepare biphasic mixtures by adding tricalcium aluminate (Ca₃Al₂O₆) into dicalcium silicate (Ca₂SiO₄) and to evaluate the effect of Ca₃Al₂O₆ on setting properties and biocompatibility of the Ca₂SiO₄/Ca₃Al₂O₆ mixtures as compared to pure Ca₂SiO₄. The results indicated that the addition of Ca₃Al₂O₆ into Ca₂SiO₄ reduced the setting time and improved the compressive strength. Furthermore, Ca₂SiO₄/Ca₃Al₂O₆ mixtures were bioactive and biocompatible, and had a stimulatory effect on the L929 cell growth when the content of Ca₃Al₂O₆ was below 10%. Therefore, the mixtures with 10% Ca₃Al₂O₆ produced the best compromise between setting and in vitro biological properties.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, China.
authors.forename: Weining
authors.initials: W
authors.lastname: Liu
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D017610:Calcium Compounds / Q000737:chemistry / Q000378:metabolism*; D002460:Cell Line; D049109:Cell Proliferation; D019245:Compressive Strength; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D008422:Materials Testing; D051379:Mice; D017640:Silicates / Q000737:chemistry / Q000378:metabolism*
chemical_list: D017607:Aluminum Compounds; D001672:Biocompatible Materials; D017610:Calcium Compounds; D017640:Silicates; C035219:calcium aluminate; C031293:calcium silicate