title: Asymmetric total synthesis of (-)-scabronine G via intramolecular double Michael reaction and Prins cyclization.
abstract: The enantioselective total synthesis of (-)-scabronine G is described. The key features of the present synthesis include the construction of a 5-6 ring system containing two quaternary carbon centers via a diastereoselective intramolecular double Michael reaction and the formation of a seven-membered ring using a Prins cyclization.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai, Japan. kanoh@mail.pharm.tohoku.ac.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Kanoh
authors.forename: Kohei
authors.initials: K
authors.lastname: Sakanishi
authors.forename: Emiko
authors.initials: E
authors.lastname: Iimori
authors.forename: Ken'ichi
authors.initials: K
authors.lastname: Nishimura
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Iwabuchi
mesh_terms: D000363:Agaricales / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; C119787:scabronine G