title: Cutaneous T-cell/histiocyte-rich B-cell lymphoma: a case report and review of the literature.
abstract: BACKGROUND
  T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) primarily presenting on the skin is an extremely rare entity with only sporadic cases reported in the literature.
  
  
  METHODS
  We here report an extraordinary case of primary cutaneous THRLBCL with self-healing and 24 months of follow-up.
  
  
  RESULTS
  The lesion was a dermohypodermal/subcutaneous circumscribed ulcerated nodosity. Histological examination with immunohistochemical, molecular analysis and comparative genomic hybridization were performed. A complete staging was negative for secondary involvement.
  
  
  CONCLUSIONS
  Our case is remarkable because it is the second well-documented primary cutaneous THRLBCL in which we observed a complete self-regression of skin lesions without recurrences or dissemination of the disease. According to the literature, we highlight that the tumoral microenvironment, in our case, could play a relevant role in stopping lymphoma growth. Furthermore, this case supports the observation that THRLBCL primarily presenting on the skin shows an overall good prognosis.
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, Italy. pamela.vezzoli@libero.it
authors.forename: Pamela
authors.initials: P
authors.lastname: Vezzoli
authors.forename: Roberta
authors.initials: R
authors.lastname: Fiorani
authors.forename: Valentina
authors.initials: V
authors.lastname: Girgenti
authors.forename: Daniele
authors.initials: D
authors.lastname: Fanoni
authors.forename: Simona
authors.initials: S
authors.lastname: Tavecchio
authors.forename: Ylenia
authors.initials: Y
authors.lastname: Balice
authors.forename: Ruggero
authors.initials: R
authors.lastname: Mozzana
authors.forename: Carlo
authors.initials: C
authors.lastname: Crosti
authors.forename: Emilio
authors.initials: E
authors.lastname: Berti
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008297:Male; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D012883:Skin Ulcer / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D055815:Young Adult
chemical_list: D015703:Antigens, CD