title: Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids.
abstract: The pyrrole-2-aminoimidazole (P-2-AI) alkaloids are a growing family of marine alkaloids, now numbering well over 150 members, with high topographical and biological information content. Their intriguing structural complexity, rich and compact stereochemical content, high N to C ratio (~1 : 2), and increasingly studied biological activities are attracting a growing number of researchers from numerous disciplines world-wide. This review surveys advances in this area with a focus on the structural diversity, biosynthetic hypotheses with increasing, but still rare, verifying experimental studies, asymmetric syntheses, and biological studies, including cellular target receptor isolation studies, of this stimulating and exciting alkaloid family.
authors.affiliation: Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France. Ali.Almourabit@icsn.cnrs-gif.fr
authors.forename: Ali
authors.initials: A
authors.lastname: Al-Mourabit
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Zancanella
authors.forename: Supriya
authors.initials: S
authors.lastname: Tilvi
authors.forename: Daniel
authors.initials: D
authors.lastname: Romo
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D007093:Imidazoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D007093:Imidazoles; D011758:Pyrroles