title: Identification of high-risk group and therapeutic options in children with liver abscess.
abstract: The outcome of children with liver abscess (LA) depends upon prompt diagnosis and intervention. We evaluated the etiology, clinical profile, various interventional modalities of management and outcome of children with LA. A total of 39 hospitalized children (mean age 7.2 ± 3.9 years) with radiologically proven LA were analyzed. Parenteral antibiotics, percutaneous drainage (PD) or open surgical drainage (OSD) was done as required. Cases with ruptured or impending rupture of LA, upper gastrointestinal bleed, jaundice, pleural effusion or consolidation were labeled as "high risk" cases. Triad of fever, pain and hepatomegaly was the most common presentation. Single abscess was present in 66.7% and right lobe was involved in 69.2% of cases. Majority of LA were pyogenic (PLA, 25/39). Amebic liver abscess (ALA) and PLA had similar clinical and laboratory profile except that multiloculated abscess on ultrasonography was a feature of PLA (12/25 vs. 0/11; p = 0.006). Cases with ALA settled significantly more often with antibiotics alone (5/11 vs. 3/25; p = 0.04) than PLA and none required surgery (0/11 vs. 7/25; p = 0.03). Subjects with "high-risk" LA (n - 26) had significantly larger abscesses, more polymorphonuclear leucocytosis (74 ± 15% vs. 61 ± 13%; p = 0.01) in peripheral blood and need of drainage (24/26 vs. 7/13; p = 0.03) than patients with average-risk LA. Based on the results, 38/39 children recovered, with complete abscess resolution in 28, over 48 ± 63.8 days. In conclusion, ALA, although similar in presentation, are uniloculated, and patients with ALA recover more often without drainage than patients with PLA. Patients with "high risk" LA are more common and have a good outcome with drainage. PD, being safe, efficacious and less invasive than OSD, should be the preferred drainage procedure.
authors.affiliation: Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Uttar Pradesh, India.
authors.forename: Anshu
authors.initials: A
authors.lastname: Srivastava
authors.forename: Surender Kumar
authors.initials: SK
authors.lastname: Yachha
authors.forename: Vikas
authors.initials: V
authors.lastname: Arora
authors.forename: Ujjal
authors.initials: U
authors.lastname: Poddar
authors.forename: Richa
authors.initials: R
authors.lastname: Lal
authors.forename: Sanjay S
authors.initials: SS
authors.lastname: Baijal
mesh_terms: D000293:Adolescent; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002439:Cefotaxime / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003023:Cloxacillin / Q000627:therapeutic use; D004322:Drainage / Q000379:methods*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007964:Leukocytosis / Q000209:etiology; D008100:Liver Abscess / Q000150:complications / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D009504:Neutrophils / Q000473:pathology; D012189:Retrospective Studies; D018570:Risk Assessment; D016896:Treatment Outcome; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D014640:Vancomycin; D002439:Cefotaxime; D003023:Cloxacillin