title: Accelerated central nervous system autoimmunity in BAFF-receptor-deficient mice.
abstract: B cell activating factor (BAFF) is critical for B cell survival, a function that is mediated by BAFF receptor, (BAFF-R). The role of BAFF (or BAFF-R) in the multiple sclerosis model, experimental autoimmune encephalomyelitis (EAE), was examined using BAFF-R-deficient mice. BAFF-R deficiency resulted in paradoxically increased severity of EAE induced by myelin-oligodendrocyte glycoprotein (MOG) peptide 35-55. Inflammatory foci in BAFF-R-deficient mice comprised increased numbers of activated macrophages expressing BAFF and correlated with increased BAFF secretion. Thus, BAFF-R may be important in EAE pathogenesis, possibly by influencing macrophage function through a mechanism that involves modulation of BAFF expression.
authors.affiliation: Department of Neurology and Neuroscience Graduate Program, University of California Davis, Davis, CA, USA. ssykim@ucdavis.edu
authors.forename: Susan S
authors.initials: SS
authors.lastname: Kim
authors.forename: David P
authors.initials: DP
authors.lastname: Richman
authors.forename: Scott S
authors.initials: SS
authors.lastname: Zamvil
authors.forename: Mark A
authors.initials: MA
authors.lastname: Agius
mesh_terms: D000818:Animals; D015551:Autoimmunity; D053265:B-Cell Activation Factor Receptor / Q000172:deficiency; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006023:Glycoproteins / Q000009:adverse effects; D008214:Lymphocytes / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000009:adverse effects; D013154:Spleen / Q000473:pathology; D018709:Statistics, Nonparametric
chemical_list: D053265:B-Cell Activation Factor Receptor; D016207:Cytokines; D006023:Glycoproteins; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; C486662:Tnfrsf13c protein, mouse; C445081:myelin oligodendrocyte glycoprotein (35-55)