title: Relationship of chromatic visual-evoked potentials and the changes of foveal photoreceptor layer in central serous chorioretinopathy patients.
abstract: OBJECTIVE
  To investigate the relative involvement of chromatic and achromatic visual subsystems in central serous chorioretinopathy, and to correlate the function changes with the changes of the foveal photoreceptor layer using Fourier domain optical coherence tomography (FD-OCT).
  
  
  METHODS
  Central serous chorioretinopathy patients and control subjects were tested and compared. Equiluminant Chromatic sinusoidal gratings were presented in a pattern onset-offset mode. We measured the distance between the internal limiting membrane (ILM) and the external limiting membrane (ELM) on FD-OCT images.
  
  
  RESULTS
  Visual evoked potential mean latency was delayed significantly in central serous chorioretinopathy patients compared to controls. The visual evoked potential delay was greater for chromatic than for achromatic stimuli. Retinal thickness from ILM to ELM was associated significantly and selectively with short-wavelength-sensitive (S) cone visual evoked potential latency (r = -0.40, p = 0.032).
  
  
  CONCLUSIONS
  These results are consistent with data that indicate the loss of photoreceptors in central serous chorioretinopathy resulting in a reduced thickness of the outer nuclear layer. Additionally, they are consistent with data which indicate that the photoreceptor loss is relatively greater in cones. The S-cone pathway was affected the most.
authors.affiliation: Eye Center, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wu
authors.forename: Yabo
authors.initials: Y
authors.lastname: Yang
authors.forename: Haojun
authors.initials: H
authors.lastname: Li
authors.forename: J Vernon
authors.initials: JV
authors.lastname: Odom
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D005584:Fovea Centralis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011859:Radiography; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000502:physiology*