title: Melatonin prevents oxidative stress in ovariectomized rats treated with aluminium.
abstract: This study is designed to determine the simultaneous effect of aluminium (Al) and melatonin (Mel) treatment in intact and ovariectomized (Ovx) female rats on oxidative stress and their inter-organ relationship in the kidney and liver. Al-treated rats received an intra-peritoneal injection of solution of aluminium lactate (0.575 mg Al/100 g of body weight, three times a week), during 12 weeks. Mel groups received intra-peritoneal injections of melatonin at a dose of 10 mg/kg/day, 5 days/week, during 12 weeks. The results of this study showed that Al treatment in female rats modifies homeostasis of glutathione and the antioxidant capacity of the rat liver and kidney. The alteration of glutathione homeostasis and oxidative status was not associated with an increased lipid peroxidation in both organs with the exception of the increase observed in the liver of Ovx rats. Al also induced modifications in the activity of some enzymes related to the glutathione cycle: GSH-Px in the liver and kidney and glutathione reductase only in the kidney. Al exposure decreased CAT activity in both the kidney and liver of intact and Ovx groups. The administration of Mel in the intact and castrated females treated with Al seems to reduce oxidative changes in the liver and kidney of intact and Ovx rats.
authors.affiliation: Laboratorio de Investigaciones Fisiológicas Experimentales. Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Ciudad Universitaria, Paraje El Pozo. CC 242, 3000, Santa Fe, Argentina. mcontini@fbcb.unl.edu.ar
authors.forename: María del Carmen
authors.initials: Mdel C
authors.lastname: Contini
authors.forename: Néstor
authors.initials: N
authors.lastname: Millen
authors.forename: Marcela
authors.initials: M
authors.lastname: González
authors.forename: Stella
authors.initials: S
authors.lastname: Mahieu
mesh_terms: D000450:Aldosterone / Q000097:blood; D000535:Aluminum / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D017607:Aluminum Compounds / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006160:Guanosine Triphosphate / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007671:Kidney Concentrating Ability / Q000187:drug effects; D007773:Lactates / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008550:Melatonin / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D010052:Ovariectomy; D018384:Oxidative Stress / Q000187:drug effects*; D010783:Photometry; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014563:Urodynamics / Q000187:drug effects; D014599:Uterus / Q000187:drug effects; D014867:Water / Q000378:metabolism
chemical_list: D017607:Aluminum Compounds; D000975:Antioxidants; D007773:Lactates; D014867:Water; D000450:Aldosterone; D006160:Guanosine Triphosphate; D000535:Aluminum; D000254:Sodium-Potassium-Exchanging ATPase; D008550:Melatonin; C104223:aluminum lactate