title: Abdominal obesity is associated with cardiovascular risk in Japanese children and adolescents.
abstract: BACKGROUND
  Metabolic syndrome is listed as a risk for atherosclerosis. However, changes in that risk during childhood and adolescence have not been well-documented. It is also unclear whether individuals with abdominal obesity, but with as yet undiagnosed metabolic syndrome, have cardiovascular risks.
  
  
  RESULTS
  Ninety-two patients were studied at the Hamamatsu University School of Medicine Department of Pediatrics. Physical measurements including abdominal circumference (AC), body mass index (BMI), body fat (BF), intima media thickness (IMT), arterial elasticity: beta index (Beta), carotid artery compliance (CAC), and Young's elastic modulus (YEM) using ultrasonography were taken. A positive correlation between systolic blood pressure, AC, BMI, and BF was observed (AC, r = 0.717, p < 0.001; BMI, r = 0.672, p < 0.001; BF, r = 0.518, p < 0.001). IMT showed a weak positive correlation with AC, BMI and BF (AC, r = 0.211, p = 0.044; BMI, r = 0.233, p = 0.025; BF, r = 0.232, p = 0.026). The relationship between AC, BMI, BF and arterial elasticity, especially in AC, positively correlated with beta index and YEM but negatively correlated with CAC.
  
  
  CONCLUSIONS
  We suggest that AC is the most sensitive marker in the detection of arterial elasticity, even in school age children. Earlier pre-diagnostic intervention, especially in the prevention of abdominal obesity, may reduce the incidence of metabolic syndrome in children and adolescents.
authors.affiliation: Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan. iwashima@hama-med.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Iwashima
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Takamichi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Shinichirou Sano Eiichiro
authors.initials: SS
authors.lastname: Satake
authors.forename: Eiko
authors.initials: E
authors.lastname: Nagata
authors.forename: Takehiko
authors.initials: T
authors.lastname: Ohzeki
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000706:statistics & numerical data; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D056128:Obesity, Abdominal / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D014463:Ultrasonography; D055105:Waist Circumference / Q000502:physiology