title: [Mechanisms of protective action of erythropoietin in cells].
abstract: Cytokine and growth factor--erythropoietin (EPO)--apart from it's hematopoietic function is now considered to be a cytoprotective agent in a variety of vascular diseases, nervous system disorders and metabolic impairments. Recent work has elucidated that erythropoietin controls a variety of signal transduction pathways involving Janus-tyrosine kinase 2, protein kinase B, signal transducer and activator of transcription, Wnt proteins, forkhead transcription factors, caspases, and nuclear factor kappaB. Further investigations of cellular pathways controlled by erythropoietin can be the base for therapeutic applicability of this cytokine throughout the body.
authors.affiliation: Uniwersytet Medyczny w Białymstoku, Klinika Neonatologii i Intensywnej Terapii Noworodka. hannaborysewicz@poczta.fm
authors.forename: Hanna
authors.initials: H
authors.lastname: Borysewicz-Sańczyk
authors.forename: Marek
authors.initials: M
authors.lastname: Szczepański
mesh_terms: D000818:Animals; D019610:Cytoprotection / Q000502:physiology*; D004921:Erythropoietin / Q000378:metabolism*; D006801:Humans; D053614:Janus Kinase 2 / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism; D009422:Nervous System Diseases / Q000378:metabolism; D011485:Protein Binding; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D053634:TYK2 Kinase / Q000378:metabolism; D014652:Vascular Diseases / Q000378:metabolism
chemical_list: D004921:Erythropoietin; D053614:Janus Kinase 2; D053634:TYK2 Kinase; D051057:Proto-Oncogene Proteins c-akt