title: [Utility of urease rapid test for detection of Helicobacter pylori in patients with upper gastrointestinal bleeding from peptic ulcer].
abstract: BACKGROUND
  Peptic ulcer disease is the main cause of upper gastrointestinal bleeding and Helicobacter pylori is its principal etiology. The sensitivity of the diagnostics tests is low for the detection of H. pylori en the setting of bleeding peptic ulcer. In addition there are different results among them.
  
  
  OBJECTIVE
  To validate the rapid urease test (RUT) in patients with bleeding peptic ulcer.
  
  
  METHODS
  We prospectively included patients older than 14 years old who presented with bleeding peptic ulcer and performed diagnostic studies of RUT and histology for the detection of H. pylori. Two biopsies were taken (one from the antrum and another one from the corpus) for RUT and four biopsies (two from both antrum and corpus) for histology. RESULTS Ninety-three patients were included, gastric ulcer was the most frequent site of the bleeding. 48 patients were positive for H. pylori by histology studies and 55 patients were positive to H. pylori by RUT. The sensitivity and specificity of the RUT were 89.6% (IC 77.3-96.5) y 73.3% (IC 58.0-85.4) respectively.
  
  
  CONCLUSIONS
  The RUT has a high sensitivity for the detection of H. pylori en the setting of bleeding peptic ulcer.
authors.affiliation: Médico Residente de Gastroenterología del Hospital Nacional Cayetano Heredia. Lima, Perú.
authors.forename: Eduar
authors.initials: E
authors.lastname: Bravo Paredes
authors.forename: Patricia
authors.initials: P
authors.lastname: Guzmán Rojas
authors.forename: Roxana
authors.initials: R
authors.lastname: Gallegos López
authors.forename: Manuel
authors.initials: M
authors.lastname: Corzo Maldonado
authors.forename: Arturo
authors.initials: A
authors.lastname: Zegarra Chang
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Surco Ochoa
authors.forename: Alejandro
authors.initials: A
authors.lastname: Piscoya Rivera
authors.forename: Jorge
authors.initials: J
authors.lastname: Huerta-Mercado Tenorio
authors.forename: Ricardo
authors.initials: R
authors.lastname: Prochazka Zárate
authors.forename: Raúl
authors.initials: R
authors.lastname: De Los Ríos Senmache
authors.forename: José
authors.initials: J
authors.lastname: Pinto Valdivia
mesh_terms: D001706:Biopsy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications / Q000382:microbiology*; D011446:Prospective Studies; D013997:Time Factors; D014510:Urease
chemical_list: D014510:Urease