title: Ectopic cervical thymic carcinoma in a dog.
abstract: A 10-year-old male German shepherd dog was referred for evaluation of a cranial cervical mass causing progressively worsening respiratory distress. A fine-needle aspirate of the mass was obtained and the cytology results were compatible with a carcinoma. The dog underwent chemotherapy without clinical improvement and was ultimately euthanased because of clinical deterioration. At post-mortem examination, an irregular multi-lobated mass in the cranial cervical region was observed causing ventro-lateral tracheal deviation. Histopathology and immunohistochemistry revealed a mixed population of CD3 lymphocytes and macrophages in an exuberant fibrous stroma, associated with dispersed cytokeratin-positive epithelial cells with marked eosinophilic cytoplasm. Some of the epithelial cells were arranged in concentric clusters that were interpreted as Hassall's corpuscles. Histopathological examination of the thyroid gland revealed several neoplastic emboli composed of epithelial cells similar to those observed in the cervical mass. To the authors' knowledge, this is the first report of an ectopic cervical thymic carcinoma in a dog.
authors.affiliation: Centro de Investigação em Ciência Veterinária (CICV), Faculdade de Medicina Veterinária, Universidade Lusófona de Humanidades e Tecnologias, Lisboa, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Faisca
authors.forename: J
authors.initials: J
authors.lastname: Henriques
authors.forename: T M
authors.initials: TM
authors.lastname: Dias
authors.forename: L
authors.initials: L
authors.lastname: Resende
authors.forename: L
authors.initials: L
authors.lastname: Mestrinho
mesh_terms: D000818:Animals; D002828:Choristoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D008297:Male; D013945:Thymoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D013950:Thymus Gland / Q000473:pathology; D013953:Thymus Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*