title: [Invasive candidiasis in critically ill adult patient].
abstract: Invasive infections by Candida strains are a relevant pathology in critically ill patients. Candida should be considered where a high risk of infection is present for a critical early diagnosis. Despite the incorporation of new drugs in the therapeutic armamentarium over the last decade, mortality remains high. The key in improving clinical outcomes of these patients are the use of early effective therapies that offer coverage against different strains of Candida: C. albicans and non-albicans. Recent international guidelines suggest empiric therapy with echinocandins in suspected invasive candidiasis in this patient population. This group of drugs adequately documented clinical efficacy and safe use in these patients. The emergence of new echinocandins could improve access to these drugs by reducing their cost.
authors.affiliation: Unidad de Paciente Crítico, Departamento de Medicina, Hospital Clínico Universidad de Chile, Santiago, Chile. etobar@redclinicauchile.cl
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tobar A
authors.forename: Francisco
authors.initials: F
authors.lastname: Silva O
authors.forename: Roberto
authors.initials: R
authors.lastname: Olivares C
authors.forename: Pablo
authors.initials: P
authors.lastname: Gaete G
authors.forename: Mario
authors.initials: M
authors.lastname: Luppi N
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D058365:Candidiasis, Invasive / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D016638:Critical Illness; D006801:Humans; D007362:Intensive Care Units; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents