title: Two pairs of epimeric indole alkaloids from Catharanthus roseus.
abstract: Two pairs of epimeric indole alkaloids (1- 4) with a chlorine atom were isolated from the aerial part of Catharanthus roseus. Their structures were established on the basis of the spectroscopic data including UV, IR, HRESIMS, NMR, and X-ray diffraction analyses. The cytotoxic activities of 1-4 against the HepG2 cell line were evaluated.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.forename: Xiang-Zhan
authors.initials: XZ
authors.lastname: Zhong
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Ren-Wang
authors.initials: RW
authors.lastname: Jiang
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
authors.forename: Jiao
authors.initials: J
authors.lastname: Wang
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D030008:Catharanthus / Q000737:chemistry*; D002470:Cell Survival; D056945:Hep G2 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D026121:Indole Alkaloids; D010936:Plant Extracts