title: [Antioxidant and cardioprotective effects of N-tyrosol in myocardial ischemia with reperfusion in rats].
abstract: We demonstrated in experiments on rats with left coronary artery occlusion that intravenous administration of 20 mg/kg n-tyrosol during ischemia limited manifestations of oxidative stress in myocardial tissue during early post reperfusion period: content of diene and triene conjugates lowered 16 and 20%, respectively. This was associated with higher preservation of cardiomyocytes and reduction of the infarction zone.
authors.forename: V I
authors.initials: VI
authors.lastname: Smol'iakova
authors.forename: G A
authors.initials: GA
authors.lastname: Chernyshova
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
authors.forename: O I
authors.initials: OI
authors.lastname: Aliev
authors.forename: E A
authors.initials: EA
authors.lastname: Krasnov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000378:metabolism; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004562:Electrocardiography; D007275:Injections, Intravenous; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D015425:Myocardial Reperfusion / Q000009:adverse effects; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D002316:Cardiotonic Agents; C011867:4-hydroxyphenylethanol; D010626:Phenylethyl Alcohol