title: Comparison of clinical and biologic features of Kingella kingae and Staphylococcus aureus arthritis at initial evaluation.
abstract: We conducted a retrospective study comparing the presenting clinical and biologic features of 64 children who had septic arthritis caused by Kingella kingae with 26 children who had septic arthritis caused by Staphylococcus aureus. Children with K. kingae septic arthritis were significantly younger than those with S. aureus septic arthritis. Otherwise, there were no significant differences between the 2 groups with respect to fever, location, white blood cell count, synovial fluid cell count, C-reactive protein, or serum fibrinogen. However, the clinical course was significantly better for children with septic arthritis caused by K. kingae as evidenced by shorter hospitalization and fewer adverse events. Presumptive antibiotic therapy for septic arthritis in young infants should take into account both of these pathogens, even in case of mild presentation.
authors.affiliation: Department of Pediatrics, Microbiology, and Pediatric Orthopaedics, Hôpital Robert Debré, Assistance Publique Hôpitaux de Paris and Université Paris Diderot, Paris, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Basmaci
authors.forename: Mathie
authors.initials: M
authors.lastname: Lorrot
authors.forename: Philippe
authors.initials: P
authors.lastname: Bidet
authors.forename: Catherine
authors.initials: C
authors.lastname: Doit
authors.forename: Christine
authors.initials: C
authors.lastname: Vitoux
authors.forename: Georges
authors.initials: G
authors.lastname: Penneçot
authors.forename: Keyvan
authors.initials: K
authors.lastname: Mazda
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
authors.forename: Brice
authors.initials: B
authors.lastname: Ilharreborde
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bonacorsi
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000382:microbiology* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D017882:Kingella kingae / Q000302:isolation & purification / Q000472:pathogenicity*; D008297:Male; D016870:Neisseriaceae Infections / Q000382:microbiology / Q000473:pathology*; D012189:Retrospective Studies; D017678:Sex Distribution; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000472:pathogenicity*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents