title: Modular 'click' sensors for zinc and their application in vivo.
abstract: Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a 'click' approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.
authors.affiliation: School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
authors.forename: Kajally
authors.initials: K
authors.lastname: Jobe
authors.forename: Caroline H
authors.initials: CH
authors.lastname: Brennan
authors.forename: Majid
authors.initials: M
authors.lastname: Motevalli
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Goldup
authors.forename: Michael
authors.initials: M
authors.lastname: Watkinson
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D008968:Molecular Conformation; D015027:Zebrafish / Q000378:metabolism; D015032:Zinc / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D015032:Zinc