title: Perivascular epithelioid cell tumor of the sigmoid colon with transcription factor E3 expression.
abstract: We describe here a 62-year-old woman who presented with a perivascular epithelioid cell tumor arising in the sigmoid colon. Computed tomography revealed a 5-cm-sized intraluminal fungating mass. Histologically, the tumor consisted of plump, epithelioid cells with abundant clear-to-lightly eosinophilic cytoplasm and round nuclei, arranged in an alveolar or trabecular pattern. The tumor cells were strongly positive for HMB-45 and TFE3, but negative for vimentin, cytokeratin, smooth muscle actin, S100 protein, CD117, CD34, synaptophysin, chromogranin, CD10, hepatocyte antigen, CD1a, and desmin. The tumor cells had a high Ki-67 labeling index (up to 20%). Fluorescent in situ hybridization showed no evidence of the EWS rearrangement. Based on these histologic and immunohistochemical features, our patient was diagnosed with a perivascular epithelioid cell tumor of the sigmoid colon.
authors.affiliation: Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
authors.forename: Miji
authors.initials: M
authors.lastname: Lee
authors.forename: Kyung-Ja
authors.initials: KJ
authors.lastname: Cho
authors.forename: Changsik
authors.initials: C
authors.lastname: Yu
authors.forename: Youngsu
authors.initials: Y
authors.lastname: Park
authors.forename: Jin Cheon
authors.initials: JC
authors.lastname: Kim
authors.forename: Jihun
authors.initials: J
authors.lastname: Kim
authors.forename: Eunsil
authors.initials: E
authors.lastname: Yu
authors.forename: Mi-Jung
authors.initials: MJ
authors.lastname: Kim
mesh_terms: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D058950:Melanoma-Specific Antigens / Q000378:metabolism; D008875:Middle Aged; D054973:Perivascular Epithelioid Cell Neoplasms / Q000378:metabolism* / Q000473:pathology; D012811:Sigmoid Neoplasms / Q000378:metabolism* / Q000473:pathology; D058951:gp100 Melanoma Antigen
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D014408:Biomarkers, Tumor; D058950:Melanoma-Specific Antigens; C548637:PMEL protein, human; C069203:TFE3 protein, human; D058951:gp100 Melanoma Antigen