title: NPY receptors as potential targets for anti-obesity drug development.
abstract: The neuropeptide Y system has proven to be one of the most important regulators of feeding behaviour and energy homeostasis, thus presenting great potential as a therapeutic target for the treatment of disorders such as obesity and at the other extreme, anorexia. Due to the initial lack of pharmacological tools that are active in vivo, functions of the different Y receptors have been mainly studied in knockout and transgenic mouse models. However, over recent years various Y receptor selective peptidic and non-peptidic agonists and antagonists have been developed and tested. Their therapeutic potential in relation to treating obesity and other disorders of energy homeostasis is discussed in this review.
authors.affiliation: Neuroscience Research Program, Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, Sydney, NSW, Australia.
authors.forename: Ernie
authors.initials: E
authors.lastname: Yulyaningsih
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Herbert
authors.initials: H
authors.lastname: Herzog
authors.forename: Amanda
authors.initials: A
authors.lastname: Sainsbury
mesh_terms: D001067:Appetite Depressants / Q000494:pharmacology*; D016503:Drug Delivery Systems; D005786:Gene Expression Regulation; D006801:Humans; D009765:Obesity / Q000517:prevention & control*; D017476:Receptors, Neuropeptide Y / Q000235:genetics / Q000378:metabolism*
chemical_list: D001067:Appetite Depressants; D017476:Receptors, Neuropeptide Y