title: Relations of adiponectin to levels of metabolic parameters and sexual hormones in elderly type 2 diabetic patients.
abstract: BACKGROUND
  Despite the effective role of adiponectin levels in the predisposition to type 2 diabetes mellitus, the potential impact of adiponectin in manifest type 2 diabetes is less studied.
  
  
  OBJECTIVE
  This study aimed to determine gender-specific differences regarding the relationship between adiponectin levels and metabolic parameters as well as sex hormones in elderly type 2 diabetics.
  
  
  METHODS
  Sixty-two elderly type 2 diabetic men (mean age 60 [9] years) and 38 postmenopausal type 2 diabetic women (mean age 64 [9] years) were evaluated in a cross-sectional study. Glycemic control, lipids, sex hormones, adiponectin, and anthropometric parameters were measured in all participants.
  
  
  RESULTS
  Serum adiponectin was higher in women than in men (P < 0.006). After controlling for age and body mass index, adiponectin concentrations showed a positive correlation with sex hormone-binding globulin and high-density lipoprotein levels (P < 0.001) and a negative correlation with glycated hemoglobin, homeostasis model assessment index for insulin resistance, glucose, C-peptide, and triglyceride levels (P < 0.05) in all patients. In men, adiponectin significantly correlated with serum levels of testosterone (r = 0.420; P < 0.002). In women, negative correlations were observed between adiponectin levels and the fatty liver index (r = -0.492; P < 0.006) and γ-glutamyltransferase (r = -0.432; P < 0.01).
  
  
  CONCLUSIONS
  High serum adiponectin is a feature of better metabolic control and lipid profile, whereas low adiponectin levels are associated with fatty liver disease in women and low testosterone levels in men with type 2 diabetes.
authors.affiliation: Unit of Gender Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Sazan
authors.initials: S
authors.lastname: Rasul
authors.forename: Aysegul
authors.initials: A
authors.lastname: Ilhan
authors.forename: Marie Helene
authors.initials: MH
authors.lastname: Reiter
authors.forename: Sabina
authors.initials: S
authors.lastname: Baumgartner-Parzer
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kautzky-Willer
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000378:metabolism; D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D045166:Estradiol Congeners / Q000097:blood* / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D045167:Progesterone Congeners / Q000097:blood* / Q000378:metabolism; D012737:Sex Factors; D012738:Sex Hormone-Binding Globulin; D013223:Statistics as Topic; D045165:Testosterone Congeners / Q000097:blood* / Q000378:metabolism
chemical_list: D052242:Adiponectin; D045166:Estradiol Congeners; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008687:Metformin; D045167:Progesterone Congeners; D012738:Sex Hormone-Binding Globulin; D045165:Testosterone Congeners; C499918:ADIPOQ protein, human