title: Episodic and semantic memory in children with mesial temporal sclerosis.
abstract: The aim of this study was to analyze semantic and episodic memory deficits in children with mesial temporal sclerosis (MTS) and their correlation with clinical epilepsy variables. For this purpose, 19 consecutive children and adolescents with MTS (8 to 16 years old) were evaluated and their performance on five episodic memory tests (short- and long-term memory and learning) and four semantic memory tests was compared with that of 28 healthy volunteers. Patients performed worse on tests of immediate and delayed verbal episodic memory, visual episodic memory, verbal and visual learning, mental scanning for semantic clues, object naming, word definition, and repetition of sentences. Clinical variables such as early age at seizure onset, severity of epilepsy, and polytherapy impaired distinct types of memory. These data confirm that children with MTS have episodic memory deficits and add new information on semantic memory. The data also demonstrate that clinical variables contribute differently to episodic and semantic memory performance.
authors.affiliation: LIM-21, Laboratory for Medical Research 21-Neuroimaging Laboratory, Department of Psychiatry, University of São Paulo School of Medicine, São Paulo, Brazil. patriciarzezak@gmail.com
authors.forename: Patricia
authors.initials: P
authors.lastname: Rzezak
authors.forename: Catarina
authors.initials: C
authors.lastname: Guimarães
authors.forename: Daniel
authors.initials: D
authors.lastname: Fuentes
authors.forename: Marilisa M
authors.initials: MM
authors.lastname: Guerreiro
authors.forename: Kette Dualibi Ramos
authors.initials: KD
authors.lastname: Valente
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000150:complications*; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D011939:Mental Recall / Q000502:physiology*; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D012598:Sclerosis / Q000209:etiology / Q000473:pathology; D012660:Semantics; D014741:Video Recording / Q000379:methods