title: [House dust mites allergens].
abstract: BACKGROUND
  House dust mite allergens from the Pyroglyphidae family are one of the most frequent and potent causes of allergic sensitatisation. Since 1988, molecular knowledge has increased considerably and structures and functions have been determined for most of them.
  
  
  BACKGROUND
  Of the 22 defined allergens, the major IgE-binding has been reported for groups 1 and 2 accounting for 40-60% of the anti-house dust mite titres. Der p 1, 2, 4, 5, 7 allergens account for about 80% of the IgE-response. Der p 4, 5, 7, 11, 14, 15 have a prevalence of sensitization of about 10% each. The IgE-binding to groups 3, 8, 10, 20 is low. Most of the allergens can be identified by amino-acid sequences and the tertiary structures of the major allergens have been solved. Most allergens are proteolytic enzymes: Der p1 for instance is a cysteine protease. Der p 2 has structural homology with MD-2, a co-receptor of the Toll-like receptor (TLR4) whose ligand is LPS. Knowledge of the structure of mite allergens has allowed better interpretation of cross-reactions between allergens from the same family or from more distant families.
  
  
  CONCLUSIONS
  From a practical point of view: the occurrence of multisensitisation is better explained and molecular epidemiology has allowed a better choice of allergen molecules useful for diagnosis. Finally, new concepts of immunotherapy based on genetically engineered hypoallergenic variants of major allergens, used alone or in combination, may lead to useful therapeutic approach.
authors.affiliation: Ariale, bâtiment ancienne ophtalmologie, hôpital Civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Bessot
authors.forename: G
authors.initials: G
authors.lastname: Pauli
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology; D003429:Cross Reactions; D003430:Cross-Sectional Studies; D003888:Desensitization, Immunologic / Q000379:methods; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D039981:Pyroglyphidae / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D007073:Immunoglobulin E