title: Therapy of desmoid tumors, fibromatosis, and related neoplasms.
abstract: Forty-seven patients with unresectable desmoid tumors and 32 patients with unresectable fibromatosis were treated with various anti-neoplastic agents including methotrexate, vinblastine, etoposide, actinomycin D, and fluorouracil. A combination of methotrexate with either vinblastine or etoposide was found to be effective in yielding long-term control to both groups of patients. Fluorouracil and actinomycin D were less effective. Other than a significant but slowly reversible peripheral neuropathy in 6 patients, therapy was well tolerated and no long-term hematologic, pulmonary, hepatic, or cardiac toxicity was noted in any patient.
authors.affiliation: THOMAS JEFFERSON UNIV,SCH MED,DEPT MED,PHILADELPHIA,PA 19107. THOMAS JEFFERSON UNIV,SCH MED,DEPT ORTHOPED SURG,PHILADELPHIA,PA 19107.
authors.forename: A
authors.initials: A
authors.lastname: Weiss
authors.forename: R
authors.initials: R
authors.lastname: Lackman