title: Surgical management of gastric gastrointestinal stromal tumor: a single center experience.
abstract: OBJECTIVE
  Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Surgery remains the mainstay of curative treatment. Our objective is to evaluate the outcome of surgical treatment of primary gastric GIST.
  
  
  METHODS
  Between January 1997 and April 2008, thirty seven consecutive patients underwent resection for GISTs (35 patients with primary gastric GISTs and two patients with intestinal GISTs who were excluded from the study). These patients underwent upper endoscopy ± biopsy, barium meal and abdominal CT scan. Patients' demographics and clinical presentations were analyzed. Perioperative parameters measured included operative times, estimated blood loss, intraoperative finding, surgical techniques, morbidity and length of hospitalization. Recurrence and survival were also analyzed.
  
  
  RESULTS
  Of the 35 patients with gastric GISTs included in the study, 63% were female. The median age was 59 ± 14 years (range, 23 to 75 years). The primary presenting symptoms were bleeding and dyspepsia; 43% of these tumors were located mainly in the body of the stomach. Tumor size was < 10 cm in 80% of the patients. The average tumor size was 6.3 ± 3.2 cm (range from 3 to 13 cm). Regarding the surgical management, 20 patients (57%) underwent gastric wedge resection, eight patients (23%) underwent partial gastrectomy and the remaining seven patients (20%) underwent total gastrectomy. Radical resections were found in 32 patients (91.5%) while palliative resections were found in three patients (8.5%). The resected lymph nodes were negative in 32 patients (91.5%). Recurrence was noted in three patients, with a median time to recurrence of 14.3 months (range, 7 to 28 months). The three- and five-years survival in patients who underwent wedge resection was 92% and 81%, respectively, where it was 95% and 87%, respectively, in patients who underwent gastrectomy (either partial or total). There were no major intraoperative complications or mortalities.
  
  
  CONCLUSIONS
  Complete surgical resection either through wedge resection or gastrectomy with negative margins remains the gold standard treatment in the management of patients with primary resectable gastric GISTs.
authors.affiliation: Gastroenterology Surgical Center, Mansoura University, Mansoura, Egypt. dr_ehab_elhanafy@yahoo.com
authors.forename: Ehab
authors.initials: E
authors.lastname: El-Hanafy
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Hemaly
authors.forename: Emad
authors.initials: E
authors.lastname: Hamdy
authors.forename: Ahmed Abd
authors.initials: AA
authors.lastname: El-Raouf
authors.forename: Nabil Gad
authors.initials: NG
authors.lastname: El-Hak
authors.forename: Ehab
authors.initials: E
authors.lastname: Atif
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult