title: [Severe gastrointestinal bleeding secondary to lornoxicam in the dog].
abstract: Six dogs with lornoxicam induced severe gastrointestinal bleeding are described. The ingested dose ranged between 0.5 - 5.1 mg/kg BW (median 0.63 mg/kg BW). The severity of the bloodloss anemia was moderate to severe with PCV values ranging between 12 - 27 % (median 16 %) and serum albumin concentrations between 12 - 22 g/l (median 16 g/l). One dog had evidence of chronic thrombocytopathia over 13 days and clinicopathologic findings of gastrointestinal bleeding over 55 days. None of the dogs developed kidney injuries. The clinical condition required transfusion of blood products in 5 of 6 cases. One dog with a perforated duodenal ulcer and septic peritonitis survived until discharge but had to be euthanized later on due to recrudescent clinical signs (hematemesis, melena). The median length of hospitalisation was 12 days (5 - 14). No correlation was seen between the ingested dose and severity of clinical signs. Lornoxicam ingestion leads to severe and longlasting gastrointestinal bleeding in the dog and requires immediate intensive therapy.
authors.affiliation: Klinik für Kleintiermedizin, Universität Zürich. peterhendrikkook@gmail.com
authors.forename: P H
authors.initials: PH
authors.lastname: Kook
authors.forename: C E
authors.initials: CE
authors.lastname: Reusch
mesh_terms: D000740:Anemia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D016913:Blood Component Transfusion / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced* / Q000628:therapy; D004285:Dogs; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D006400:Hematocrit / Q000662:veterinary; D007902:Length of Stay; D008297:Male; D010894:Piroxicam / Q000009:adverse effects / Q000031:analogs & derivatives*; D012709:Serum Albumin / Q000032:analysis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012709:Serum Albumin; D010894:Piroxicam; C059451:lornoxicam