title: Cytogenetic findings in 14 benign cartilaginous neoplasms.
abstract: Benign cartilaginous tumors represent a spectrum of neoplastic processes with variable clinical and pathologic presentations. These tumors are histologically characterized by the presence of chondrocytes surrounded by a cartilaginous matrix. Few studies describe karyotypic abnormalities in these benign lesions. We report a series of 14 chondromas from a single institution. Conventional cytogenetics was performed on short term cultures from all cases. Clonal chromosome aberrations were found in nine tumors. One soft tissue chondroma contained three clones with t(6;12)(q12;p11.2), t(3;7)(q13;p12), and der(2)t(2;18)(p11.2;q11.2). Three periosteal chondromas displayed random structural aberrations of chromosomes 2, 3, 6, 7, and 11 and loss of chromosome 13. Among the enchondromas, three tumors displayed chromosome losses, one contained a complex translocation involving chromosomes 12, 15, and 21 as well as an inv(2)(p21q31),t(12;15;21)(q13;q14;q22) and a separate enchondroma showed a translocation involving chromosomes 12 and 22. Our data suggest that considerable cytogenetic heterogeneity exists among benign chondromatous tumors.
authors.affiliation: Molecular Pathology Division, Sarah Network of Rehabilitation Hospitals, Brasilia, DF, Brazil. nilo@sarah.br
authors.forename: Nilo
authors.initials: N
authors.lastname: Sakai Junior
authors.forename: Kikue Terada
authors.initials: KT
authors.lastname: Abe
authors.forename: Lia Menezes
authors.initials: LM
authors.lastname: Formigli
authors.forename: Marcio Fernandes
authors.initials: MF
authors.lastname: Pereira
authors.forename: Maria Dulce Valverde
authors.initials: MD
authors.lastname: de Oliveira
authors.forename: Deborah Afonso
authors.initials: DA
authors.lastname: Cornelio
authors.forename: Alessandra
authors.initials: A
authors.lastname: de La Roque Ferreira
authors.forename: Ricardo Karam
authors.initials: RK
authors.lastname: Kalil
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002812:Chondroma / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic