title: Clinical analysis of the treatment of spinocerebellar ataxia and multiple system atrophy-cerebellar type with umbilical cord mesenchymal stromal cells.
abstract: OBJECTIVE
  The aims of this study were to observe the safety and effectiveness of umbilical cord mesenchymal stromal cells (UC-MSC) in the treatment of spinocerebellar ataxia (SCA) and multiple system atrophy-cerebellar type (MSA-C).
  
  
  METHODS
  From October 2009 to September 2010, 14 cases of SCA and 10 cases of MSA-C were given UC-MSC by weekly intrathecal injection, at a dose of 1 × 10(6)/kg four times as one course. All the patients received one course of treatment, except three patients who received two courses. The movement ability and quality of daily life were evaluated with the International Cooperative Ataxia Rating Scale (ICARS) and Activity of Daily Living Scale (ADL) and the scores compared with those before cell therapy. A follow-up of 6-15 months was carried out for all of the patients.
  
  
  RESULTS
  The results showed that the ICARS and ADL scores were significantly decreased 1 month after treatment (P < 0.01). The symptoms, including unstable walking and standing, slow movement, fine motor disorders of the upper limbs, writing difficulties and dysarthria, were greatly improved except for one patient, who had no response. The observed side-effects included dizziness (four patients), back pain (two cases) and headache (one case), which disappeared within 1-3 days. During the follow-up, 10 cases remained stable for half a year or longer, while 14 cases had regressed to the status prior to the treatment within 1-14 months (an average of 3 months).
  
  
  CONCLUSIONS
  Intrathecal injection of UC-MSC is safe and can delay the progression of neurologic deficits for SCA and MSA-C patients.
authors.affiliation: Department of Hematology, General Hospital of the Air Force, Beijing, China.
authors.forename: Han
authors.initials: H
authors.lastname: Dongmei
authors.forename: Liu
authors.initials: L
authors.lastname: Jing
authors.forename: Xue
authors.initials: X
authors.lastname: Mei
authors.forename: Zhu
authors.initials: Z
authors.lastname: Ling
authors.forename: Yan
authors.initials: Y
authors.lastname: Hongmin
authors.forename: Wang
authors.initials: W
authors.lastname: Zhidong
authors.forename: Ding
authors.initials: D
authors.lastname: Li
authors.forename: Guo
authors.initials: G
authors.lastname: Zikuan
authors.forename: Wang
authors.initials: W
authors.lastname: Hengxiang
mesh_terms: D000328:Adult; D001284:Atrophy; D018450:Disease Progression; D004244:Dizziness / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D011183:Postoperative Complications; D011788:Quality of Life; D020127:Recovery of Function; D012720:Severity of Illness Index; D020754:Spinocerebellar Ataxias / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D033581:Stem Cell Transplantation; D011795:Surveys and Questionnaires; D014470:Umbilical Cord / Q000166:cytology