title: Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study.
abstract: OBJECTIVE
  Oxidative stress plays a critical role in the initiation and progression of atherosclerosis. Myeloperoxidase (MPO) is a marker of oxidative stress. We prospectively investigated whether an increased serum concentration of MPO is associated with an increased risk of incident coronary heart disease (CHD).
  
  
  METHODS
  We conducted a population-based case-cohort study in middle-aged, healthy men and women within the MONICA/KORA Augsburg studies. Serum levels of MPO were measured in 333 subjects with (cases) and 1727 without (noncases) incident CHD. Mean follow-up time was 10.8 ± 4.6 years.
  
  
  RESULTS
  Baseline concentrations of MPO were higher in cases compared with noncases (P ≤ 0.001 in men; P=0.131 in women). After adjustment for major cardiovascular risk factors, the hazard ratio (HR) with 95% confidence interval (CI) comparing the top with the two lower tertiles was 1.70 (95% CI, 1.25-2.30). After additional adjustment for markers of inflammation and endothelial dysfunction, the association was attenuated (HR 1.50; 95% CI, 1.08-2.09). There were no significant interactions of MPO with sex or increased weight on CHD risk.
  
  
  CONCLUSIONS
  Elevated concentrations of the oxidative stress marker MPO were independently associated with increased risk of incident CHD. This finding deserves detailed evaluation in further studies.
authors.affiliation: Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Karakas
authors.forename: W
authors.initials: W
authors.lastname: Koenig
authors.forename: A
authors.initials: A
authors.lastname: Zierer
authors.forename: C
authors.initials: C
authors.lastname: Herder
authors.forename: W
authors.initials: W
authors.lastname: Rottbauer
authors.forename: J
authors.initials: J
authors.lastname: Baumert
authors.forename: C
authors.initials: C
authors.lastname: Meisinger
authors.forename: B
authors.initials: B
authors.lastname: Thorand
mesh_terms: D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology*; D009195:Peroxidase / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D009195:Peroxidase