title: Prognostic implications of loss of heterozygosity in the 17q21 region in breast cancer.
abstract: Sporadic breast cancer is the commonest form of this malignancy. Genetic changes are frequent events in breast cancer. We investigated the implication of LOH in the 17q21 region as a prognostic factor in this disease. Fifty-three patients were studied and 14 clinico-pathological parameters were evaluated for comparison between the patients with LOH and patients without LOH. A LOH rate of 21% was found and, upon comparison of the two subgroups, a significantly lower rate of recurrence after adjuvant chemotherapy in patients with LOH was observed. This suggests that LOH occurring in this region in breast cancer could help to design new adjuvant treatment strategies.
authors.affiliation: CLIN TRABAJO,MOL GENET UNIT,MADRID 28003,SPAIN. CLIN PUERTA DE HIERRO,DEPT MED ONCOL,MADRID 28035,SPAIN. HOSP SANTA CRISTINA,DEPT PATHOL,E-28009 MADRID,SPAIN. HOSP GEN GREGORIO MARANON,DEPT PATHOL,MADRID 28009,SPAIN.
authors.forename: B
authors.initials: B
authors.lastname: Gomendio
authors.forename: J
authors.initials: J
authors.lastname: Silva
authors.forename: M
authors.initials: M
authors.lastname: Provencio
authors.forename: J
authors.initials: J
authors.lastname: Garcia
authors.forename: E
authors.initials: E
authors.lastname: Garciapatino
authors.forename: C
authors.initials: C
authors.lastname: Garciaandrade
authors.forename: L
authors.initials: L
authors.lastname: Carretero
authors.forename: P
authors.initials: P
authors.lastname: Espana
authors.forename: F
authors.initials: F
authors.lastname: Bonilla