title: Antioxidant activity of eugenol: a structure-activity relationship study.
abstract: Eugenol (4-allyl-2-methoxyphenol), a major phenolic component from clove oil (Eugenia caryophyllata), has several biological activities. To estimate the capacity of eugenol to act as an antioxidant, the following were studied: 1,1-diphenyl-2-picryl-hydrazyl-, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)-, and N,N-dimethyl-p-phenylenediamine-scavenging activity; total antioxidant activity; and ability to reduce ferric ions and cupric ions. Eugenol inhibited 96.7% (r(2)=0.9319) lipid peroxidation of a linoleic acid emulsion at a 15-μg/mL concentration. Butylated hydroxyanisole, butylated hydroxytoluene, α-tocopherol, and Trolox(®) displayed 95.4% (r(2)=0.8482), 99.7% (r(2)=0.7798), 84.6% (r(2)=0.9272), and 95.6% (r(2)=0.8511) inhibition of peroxidation, respectively, at the 15-μg/mL concentration. According to the results of this study, eugenol had the most powerful antioxidant activity and radical-scavenging activity. This study should prompt further studies of the antioxidant properties of eugenol.
authors.affiliation: Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, Turkey. igulcin@atauni.edu.tr
authors.forename: İlhami
authors.initials: İ
authors.lastname: Gülçin
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D045783:Clove Oil / Q000737:chemistry; D005054:Eugenol / Q000737:chemistry / Q000494:pharmacology*; D005520:Food Preservatives / Q000737:chemistry / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors / Q000737:chemistry; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D045783:Clove Oil; D005520:Food Preservatives; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D005054:Eugenol