title: Clinical experience with a novel bovine collagen dura mater substitute.
abstract: Dural substitutes are used to achieve watertight closure of the dura mater when adequate closure is not possible. The purpose of this study was to evaluate the efficacy and safety of a new collagen matrix dural substitute (Duradry, Technodry, Belo Horizonte MG) in the repair or expansion of cranial and spinal dura mater.
  
  
  METHODS
  Thirty patients, operated on between March and September, 2008, were studied. Surgical records were reviewed for sex, age, location of graft, technique, and presence of fistula or infection. The patients were followed up for at least 3 months, and presence of complications, such as cerebrospinal fluid leakage, infection, aseptic meningitis hydrocephalus, pseudomeningocele, was analyzed.
  
  
  RESULTS
  Only one patient presented cerebrospinal fluid fistula. No patients presented wound infections, hydrocephalus, pseudomenigocele, meningitis, brain abscesses or signs of toxicity related to the dural substitute.
  
  
  CONCLUSIONS
  The new dural substitute used in this study is effective and safe, and the initial results are similar to those of other dural substitutes reported in the literature.
authors.affiliation: Department of Neurosurgery, Hospital Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil. costabs@gmail.com
authors.forename: Bruno Silva
authors.initials: BS
authors.lastname: Costa
authors.forename: George de Albuquerque
authors.initials: Gde A
authors.lastname: Cavalcanti-Mendes
authors.forename: Marcelo Sartori de
authors.initials: MS
authors.lastname: Abreu
authors.forename: Atos Alves de
authors.initials: AA
authors.lastname: Sousa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use*; D003399:Craniotomy / Q000379:methods; D004388:Dura Mater / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; D003094:Collagen