title: Distribution of micafungin in the tissue fluids of patients with invasive fungal infections.
abstract: The distribution of micafungin (MCFG) in tissue fluids, such as cerebrospinal fluid (CSF), pleural effusions, ascites, and wound tissue fluids, was examined in seven patients with invasive fungal infections. MCFG (100-300 mg) was administered once daily over a 1-h intravenous infusion. Blood and tissue fluid samples were collected from 1 to 24 h after infusion. Although two patients had similar MCFG concentrations in their plasma, the concentrations in the CSF differed between these two patients. The concentration in the CSF of one patient was much higher than the MIC(90) for Candida albicans, Candida glabrata, and Aspergillus fumigatus, whereas the MCFG concentration in the CSF of the other patient was comparable to the MIC(90). By contrast, MCFG concentrations in pleural effusions, ascites, and wound tissue fluids were above the MIC(90). These results suggest that intravenous MCFG may be effective to treat invasive fungal infections that invade the organs and tissues.
authors.affiliation: Department of Disaster and Emergency Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yamada
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kumada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kishino
authors.forename: Nobuo
authors.initials: N
authors.lastname: Mochizuki
authors.forename: Keiko
authors.initials: K
authors.lastname: Ohno
authors.forename: Shinji
authors.initials: S
authors.lastname: Ogura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001201:Ascites / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism; D054714:Echinocandins / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D055666:Lipopeptides / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy / Q000378:metabolism*; D010996:Pleural Effusion / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin