title: Conjugated linoleic acid (CLA): is it time to supplement asthma therapy?
abstract: The limitations and side effects of existing asthma therapies prompt interest in complementary and alternative therapies. Conjugated linoleic acids (CLA) are a family of natural fatty acids found primarily in beef and dairy products. These molecules have a variety of biological properties which suggest potential benefit in asthma, including effects on energy regulation, lipid metabolism, inflammation and immune function. Here we review the evidence for these effects from pre-clinical and clinical studies, their significance in the context of human asthma, and discuss the potential role for CLA supplementation in asthma management.
authors.affiliation: Providence Healthcare Heart + Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. ruth.macredmond@hli.ubc.ca
authors.forename: Ruth
authors.initials: R
authors.lastname: Macredmond
authors.forename: Delbert R
authors.initials: DR
authors.lastname: Dorscheid
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D019587:Dietary Supplements; D004353:Drug Evaluation, Preclinical; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D018927:Anti-Asthmatic Agents; D044243:Linoleic Acids, Conjugated