title: NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses.
abstract: Hippocampal mossy fiber synapses have been reported to lack NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of AMPA excitatory postsynaptic currents (EPSCs), unlike conventional glutamatergic synapses. An explanation for this difference may reside in the relatively low number of NMDARs at these synapses. Because mossy fiber synapses display LTP selective for NMDARs, we examined whether this would affect the plasticity rules at mossy fiber-CA3 synapses in mouse hippocampal slices. We found that LTP of NMDARs serves as a metaplastic switch making mossy fiber synapses competent for generating NMDAR-dependent LTP of AMPA EPSCs.
authors.affiliation: University de Bordeaux, Interdisciplinary Institute for Neuroscience, Bordeaux, France.
authors.forename: Nelson
authors.initials: N
authors.lastname: Rebola
authors.forename: Mario
authors.initials: M
authors.lastname: Carta
authors.forename: Frederic
authors.initials: F
authors.lastname: Lanore
authors.forename: Christophe
authors.initials: C
authors.lastname: Blanchet
authors.forename: Christophe
authors.initials: C
authors.lastname: Mulle
mesh_terms: D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D017774:Long-Term Potentiation / Q000187:drug effects; D051379:Mice; D019599:Mossy Fibers, Hippocampal / Q000187:drug effects / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid