title: Headache among mesial temporal lobe epilepsy patients: a case-control study.
abstract: Epilepsy and headache are two chronic disorders that are characterized by recurrent attacks, but the relationship between them is not completely understood. Using a structured questionnaire, we investigated the prevalence of headache during the previous year in a homogeneous group of 100 patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). The control group consisted of 100 age-matched individuals who were randomized from a nationwide Brazilian headache database. There was a significantly higher prevalence of headache (92%) among the MTLE-HS patients when compared with the controls (73%; p=0.001). Chronic daily headache (CDH) was significantly associated with MTLE-HS (OR 6.1, CI 95% 1.7-22, p=0.005). We did not find any association between the diagnosis of migraine or tension-type headache and MTLE-HS. This study showed that MTLE-HS increases the likelihood of a headache diagnosis. In addition, CDH was more prevalent among the MTLE-HS patients, which supports a common pathophysiological mechanism for epilepsy and headache.
authors.affiliation: Centro de Epilepsia de Santa Catarina (CEPESC), Hospital Governador Celso Ramos (HGCR), Florianópolis, SC, Brazil. jeanmedic@hotmail.com
authors.forename: Jean Costa
authors.initials: JC
authors.lastname: Nunes
authors.forename: Danielle Brandes
authors.initials: DB
authors.lastname: Zakon
authors.forename: Lucia Sukys
authors.initials: LS
authors.lastname: Claudino
authors.forename: Ricardo
authors.initials: R
authors.lastname: Guarnieri
authors.forename: Fernanda Costa
authors.initials: FC
authors.lastname: Nunes
authors.forename: Luiz Paulo
authors.initials: LP
authors.lastname: Queiroz
authors.forename: Katia
authors.initials: K
authors.lastname: Lin
authors.forename: Roger
authors.initials: R
authors.lastname: Walz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004833:Epilepsy, Temporal Lobe / Q000150:complications*; D005260:Female; D006261:Headache / Q000209:etiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D055815:Young Adult