title: Highly regioselective carbonylation of unactivated C(sp3)-H bonds by ruthenium carbonyl.
abstract: The regioselective carbonylation of unactivated C(sp(3))-H bonds of aliphatic amides was achieved using Ru(3)(CO)(12) as a catalyst. The presence of a 2-pyridinylmethylamine moiety in the amide is crucial for a successful reaction. The reaction shows a preference for C-H bonds of methyl groups as opposed to methylene C-H bonds and tolerates a variety of functional groups. The stoichiometric reaction of an amide with Ru(3)(CO)(12) gave a dinuclear ruthenium complex in which the 2-pyridinylmethylamino moiety was coordinated to the ruthenium center in an N,N manner.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Nao
authors.initials: N
authors.lastname: Hasegawa
authors.forename: Valentine
authors.initials: V
authors.lastname: Charra
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Fukumoto
authors.forename: Naoto
authors.initials: N
authors.lastname: Chatani