title: Impact of physiological ventricular deformation on the morphology of the T-wave: a hybrid, static-dynamic approach.
abstract: Ventricular wall deformation is widely assumed to have an impact on the morphology of the T-wave that can be measured on the body surface. This study aims at quantifying these effects based on an in silico approach. To this end, we used a hybrid, static-dynamic approach: action potential propagation and repolarization were simulated on an electrophysiologically detailed but static 3-D heart model while the forward calculation accounted for ventricular deformation and the associated movement of the electrical sources (thus, it was dynamic). The displacement vectors that describe the ventricular motion were extracted from cinematographic and tagged MRI data using an elastic registration procedure. To probe to what extent the T-wave changes depend on the synchrony/asynchrony of mechanical relaxation and electrical repolarization, we created three electrophysiological configurations, each with a unique QT time: a setup with physiological QT time, a setup with pathologically short QT time (SQT), and pathologically long QT time (LQT), respectively. For all three electrophysiological configurations, a reduction of the T-wave amplitude was observed when the dynamic model was used for the forward calculations. The largest amplitude changes and the lowest correlation coefficients between the static and dynamic model were observed for the SQT setup, followed by the physiological QT and LQT setups.
authors.affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany. david.keller@kit.edu
authors.forename: David U J
authors.initials: DU
authors.lastname: Keller
authors.forename: Oussama
authors.initials: O
authors.lastname: Jarrousse
authors.forename: Thomas
authors.initials: T
authors.lastname: Fritz
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ley
authors.forename: Olaf
authors.initials: O
authors.lastname: Dossel
authors.forename: Gunnar
authors.initials: G
authors.lastname: Seemann
mesh_terms: D000328:Adult; D003198:Computer Simulation; D004562:Electrocardiography / Q000379:methods*; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008955:Models, Cardiovascular; D016276:Ventricular Function / Q000502:physiology*; D058067:Wavelet Analysis