title: [Clinicopathological analysis of testicular mixed germ cell tumor].
abstract: OBJECTIVE
  To investigate the clinicopathological characteristics of primary testicular mixed germ cell tumor (MGCT).
  
  
  METHODS
  We retrospectively analyzed the clinicopathological data of 13 cases of primary testicular MGCT and reviewed other relevant literature.
  
  
  RESULTS
  MGCT accounted for 24.1% (13/54) of all the testicular germ cell tumors diagnosed in our hospital. The patients ranged in age from 2 to 53 years, averaging at 28.3 years. All were unilateral cases, 6 in the left and 7 in the right testis, with a left/right ratio of 0.86:1. Morphologically, testicular MGCT displayed a variety of subtypes, embryonal carcinoma in 11 cases (84.6%), seminoma in 8 (61.5%), teratoma in 6 (46.2%), choriocarcinoma in 4 (30.8%) and yolk sac tumor in 4 (30.8%). Nine of the cases (69.2%) were composed of two different germ cell histological elements, 3 (23.1%) composed of three, and 1 (7.7%) composed of five.
  
  
  CONCLUSIONS
  Testicular MGCT is rather rare and most commonly occurs in young men. Its biological behavior, clinical management and prognosis vary with its different histological elements. Therefore accurate pathological diagnosis is essential and immunohistochemistry plays an important role in the diagnosis and differential diagnosis of testicular MGCT.
authors.affiliation: Department of Pathology, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China. zcf_314@yahoo.cn
authors.forename: Chun-Fang
authors.initials: CF
authors.lastname: Zhang
authors.forename: Chong
authors.initials: C
authors.lastname: Liu
authors.forename: Qun-Li
authors.initials: QL
authors.lastname: Shi
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.forename: Heng-Hui
authors.initials: HH
authors.lastname: Ma
authors.forename: Hang-Bo
authors.initials: HB
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D012189:Retrospective Studies; D013736:Testicular Neoplasms / Q000473:pathology*; D055815:Young Adult