title: Leptin and the central nervous system control of glucose metabolism.
abstract: The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders.
authors.affiliation: Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98195, USA. gjmorton@u.washington.edu
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Morton
authors.forename: Michael W
authors.initials: MW
authors.lastname: Schwartz
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D050154:Adiposity / Q000502:physiology; D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D003920:Diabetes Mellitus / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000502:physiology; D053612:Janus Kinases / Q000378:metabolism; D020738:Leptin / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D007328:Insulin; D020738:Leptin; D019869:Phosphatidylinositol 3-Kinases; D053612:Janus Kinases; D005947:Glucose