title: [Anti-NMDA-receptor encephalitis: description of the syndrome in connection with the first Hungarian patient].
abstract: In the majority of cases, anti-NMDA (N-methyl-D-aspartate) receptor encephalitis is a severe, but treatable disorder, therefore early diagnosis and adequate therapy are very important. It should be suspected in children and young women, who develop acute psychiatric symptoms and seizures. During the course of the disease severe encephalopathy, agitation, hallucinations, orofacial dyskinesias, prolonged cognitive disturbance, autonomic symptoms can be observed and akinetic mutism develops. EEG shows diffuse slowing. Brain MRI is normal or unspecific. Elevated protein, pleiocytosis and oligoclonal bands can be present in the CSF Detection of NMDA-receptor antibodies in sera or CSF confirms diagnosis. We present the case of a 15-year-old girl, who fully recovered within two months after steroid treatment and repeated plasma exchange. Ovarian teratoma has not been detected.
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ, Gyermekklinika. katalin.hollody@aok.pte.hu
authors.forename: Katalin
authors.initials: K
authors.lastname: Hollódy
authors.forename: Györgyi
authors.initials: G
authors.lastname: Csábi
authors.forename: Anikó
authors.initials: A
authors.lastname: Láng
authors.forename: Barnabás
authors.initials: B
authors.lastname: Rózsai
authors.forename: Hedvig
authors.initials: H
authors.lastname: Komáromy
authors.forename: László
authors.initials: L
authors.lastname: Bors
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Illés
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000405:Akinetic Mutism / Q000276:immunology*; D000927:Anticonvulsants / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood* / Q000134:cerebrospinal fluid*; D001379:Azathioprine / Q000627:therapeutic use; D003072:Cognition Disorders / Q000276:immunology*; D003937:Diagnosis, Differential; D004569:Electroencephalography; D004830:Epilepsy, Tonic-Clonic / Q000276:immunology*; D005260:Female; D006212:Hallucinations / Q000276:immunology*; D006801:Humans; D006814:Hungary; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D020363:Limbic Encephalitis / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D043025:Oligoclonal Bands / Q000097:blood / Q000134:cerebrospinal fluid; D010051:Ovarian Neoplasms / Q000175:diagnosis; D010951:Plasma Exchange; D010956:Plasmapheresis; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D013577:Syndrome
chemical_list: D000305:Adrenal Cortex Hormones; D000927:Anticonvulsants; D001323:Autoantibodies; D007166:Immunosuppressive Agents; D043025:Oligoclonal Bands; D016194:Receptors, N-Methyl-D-Aspartate; D001379:Azathioprine