title: The different phenotypes of polycystic ovary syndrome: no advantages for identifying women with aggravated insulin resistance or impaired lipids.
abstract: BACKGROUND
  According to the classification of polycystic ovary syndrome (PCOS) published by the Androgen Excess Society (AES), 10 different phenotypes of the condition are possible. The question remains of whether using these phenotypes might enable us to identify women with impaired insulin resistance or an impaired lipid profile among patients with PCOS.
  
  
  METHODS
  A prospective cohort analysis was performed of 313 women with diagnosed PCOS and 80 control individuals. The screening panel included a physical examination, weight and height measurement, ultrasonography of the ovaries, and hormone, glucose, lipid, and insulin resistance measurements.
  
  
  RESULTS
  There were no statistically significant differences in insulin resistance parameters between the different phenotypes. There were no statistically significant differences in body mass index (BMI) in any of the groups, but BMI showed the best correlation with insulin resistance in all women with PCOS and controls. Sex hormone-binding globulin (SHBG) was inversely correlated with insulin resistance in women with PCOS and controls. High-density lipoprotein (HDL) was negatively correlated with insulin resistance, and free testosterone was positively correlated with it, only in women with PCOS.
  
  
  CONCLUSIONS
  Using the different phenotypes described in the AES classification shows no advantages for identifying women with aggravated insulin resistance or impaired lipid profile among patients with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Cupisti
authors.forename: L
authors.initials: L
authors.lastname: Haeberle
authors.forename: C
authors.initials: C
authors.lastname: Schell
authors.forename: H
authors.initials: H
authors.lastname: Richter
authors.forename: C
authors.initials: C
authors.lastname: Schulze
authors.forename: T
authors.initials: T
authors.lastname: Hildebrandt
authors.forename: P G
authors.initials: PG
authors.lastname: Oppelt
authors.forename: M W
authors.initials: MW
authors.lastname: Beckmann
authors.forename: R
authors.initials: R
authors.lastname: Dittrich
authors.forename: A
authors.initials: A
authors.lastname: Mueller
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D050171:Dyslipidemias / Q000209:etiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000097:blood; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology*; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D008075:Lipoproteins, HDL; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone