title: Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.
abstract: The correlation between low serum PG level and H. pylori infection with the development of gastric cancer has caused considerable concerns all over the world. Some authors exclaimed that gastric cancer developed only in patients infected with H. pylori, whereas the other had different findings. In this study, 1,501 adult local residents with determined serum PG levels and anti H. pylori IgG status were followed for 14 years for the development of gastric cancer in a rural community with high risk of gastric cancer in Hebei Province, China. The results showed the accumulated gastric cancer incidence in the subjects with abnormal PG level and those with H. pylori infection were all significantly higher than that in the corresponding normal controls (53.9‰ vs. 12.7‰, p < 0.05 and 23.1‰ vs. 5.93‰, p < 0.05). The highest gastric cancer incidence was seen in the subjects with both abnormal serum PG and positive H. pylori (56.0‰), and followed by the subjects with abnormal PG and negative H. pylori (47.6‰) and those with normal serum PG and positive H. pylori (18.4‰). The abnormal serum PG level (OR 3.029) and H. pylori infection (OR 4.345) were all risk factors for the development of gastric cancer. The results suggested that the subjects with abnormal serum PG level and/or positive H. pylori infection in the rural area of China were all high risk population for gastric carcinoma and the subjects with both abnormal serum PG and positive H. pylori infection were at especially high risk for the development of gastric carcinoma.
authors.affiliation: Department of Pathology, Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. zhangxianghong2008@163.com
authors.forename: Xianghong
authors.initials: X
authors.lastname: Zhang
authors.forename: Liying
authors.initials: L
authors.lastname: Xue
authors.forename: Lingxiao
authors.initials: L
authors.lastname: Xing
authors.forename: Junling
authors.initials: J
authors.lastname: Wang
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Cui
authors.forename: Jianmin
authors.initials: J
authors.lastname: Mi
authors.forename: Xin
authors.initials: X
authors.lastname: Xing
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Du
authors.forename: Junichi
authors.initials: J
authors.lastname: Misumi
authors.forename: Qingbao
authors.initials: Q
authors.lastname: Tian
authors.forename: Liqin
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People; D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D020115:Pepsinogen C / Q000097:blood*; D012307:Risk Factors; D012424:Rural Population; D013274:Stomach Neoplasms / Q000097:blood* / Q000821:virology*
chemical_list: D014408:Biomarkers, Tumor; D020115:Pepsinogen C; D020116:Pepsinogen A