title: Comparison of real-time sonoelastography with T2-weighted endorectal magnetic resonance imaging for prostate cancer detection.
abstract: OBJECTIVE
  The purpose of this study was to compare the value of real-time sonoelastography with T2-weighted endorectal magnetic resonance imaging (MRI) for prostate cancer detection.
  
  
  METHODS
  Thirty-three patients with an elevated prostate-specific antigen level were investigated with real-time sonoelastography and T2-weighted endorectal MRI for prostate cancer diagnosis before systematic prostate biopsy. Real-time sonoelastography was performed to assess prostate tissue elasticity, and hard areas were considered suspicious for prostate cancer. Low-signal intensity nodules on T2-weighted endorectal MRI were considered suspicious for prostate cancer. Imaging findings were assigned to 6 areas of the peripheral zone (sextants), and their cancer detection rates were compared.
  
  
  RESULTS
  Overall, prostate cancer was detected in 13 of 33 patients (39.4%). Both real-time sonoelastography and T2-weighted endorectal MRI detected 11 cancer-positive patients (84.6%). Real-time sonoelastography showed 27 suspicious lesions in 198 sextants, and 15 (55.6%) were cancer positive. T2-weighted endorectal MRI showed 31 suspicious lesions in 198 sextants, and 13 (40.6%) were cancer positive. These findings resulted in sensitivity rates and negative predictive values per patient of 84.6% and 86.7%, respectively, for sonoelastography and 84.6% and 83.3% for MRI. The per-sextant analysis showed sensitivity rates and negative predictive values of 57.7% and 93.6% for sonoelastography and 50.0% and 92.2% for MRI.
  
  
  CONCLUSIONS
  Real-time sonoelastography showed comparable results as T2-weighted endorectal MRI for prostate cancer detection.
authors.affiliation: Department of Radiology II, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. friedrich.aigner@uki.at
authors.forename: Friedrich
authors.initials: F
authors.lastname: Aigner
authors.forename: Leo
authors.initials: L
authors.lastname: Pallwein
authors.forename: Michael
authors.initials: M
authors.lastname: Schocke
authors.forename: Andrei
authors.initials: A
authors.lastname: Lebovici
authors.forename: Lebovici
authors.initials: L
authors.lastname: Andrei
authors.forename: Daniel
authors.initials: D
authors.lastname: Junker
authors.forename: Georg
authors.initials: G
authors.lastname: Schäfer
authors.forename: Gregor
authors.initials: G
authors.lastname: Mikuz
authors.forename: Florian
authors.initials: F
authors.lastname: Pedross
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Horninger
authors.forename: Werner
authors.initials: W
authors.lastname: Jaschke
authors.forename: Ethan J
authors.initials: EJ
authors.lastname: Halpern
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Frauscher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003199:Computer Systems; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity