title: Opioidergic consequences of dietary-induced binge eating.
abstract: Endogenous opioids are involved in the hedonic aspects of eating. Opioid impairments and alterations have been implicated in the pathophysiology of bulimia nervosa and binge eating disorder. Specific contributions by Bartley G. Hoebel have furthered the understanding how cyclical caloric restriction and intermittent optional access to sugar solutions result in opioid-like forebrain neural alterations and dependency in rodents. The present study sought to investigate caudal brainstem and nodose ganglion mu-opioid receptor mRNA alterations in a rodent model of dietary-induced binge eating of sweetened fat (vegetable shortening blended with 10% sucrose). Five groups (n=7 or 8) of adult female Sprague Dawley rats were exposed to various dietary conditions for 6 weeks. As measured by in situ hybridization, there was reduced (approximately 25% from naive) mu-opioid receptor mRNA in the nucleus of the solitary tract (NTS) in the binge access group, which had intermittent calorie restriction and optional limited access to the sweetened fat. A similar reduction in expression was demonstrated in the continuous access group, which has unlimited optional sweetened fat and an obese phenotype. In the nodose ganglion, mu-opioid receptor mRNA was increased (approximately 30% from groups with sweetened fat access) in rats with intermittent caloric restriction alone. Our findings and the body of work from the Hoebel laboratory suggest that dietary-induced binge eating can consequentially alter opioidergic forebrain and hindbrain feeding-related neural pathways. Future work is needed to determine whether similar alterations are involved in the maintenance and progression of binge eating and other related eating pathologies.
authors.affiliation: Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA. ntbello@rci.rutgers.edu
authors.forename: Nicholas T
authors.initials: NT
authors.lastname: Bello
authors.forename: Zachary W
authors.initials: ZW
authors.lastname: Patinkin
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Moran
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000378:metabolism*; D002032:Bulimia / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D004032:Diet; D004435:Eating / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D009434:Neural Pathways / Q000378:metabolism*; D009620:Nodose Ganglion / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017450:Receptors, Opioid, mu / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D017450:Receptors, Opioid, mu