title: Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats.
abstract: The pathological influences of inflammation on left ventricular hypertrophy (LVH) were studied in subtotal nephrectomized (SNx) rats after 0.3% NaCl loading for 5 weeks. We found that mild hypertension, increased plasma levels of creatinine, inorganic phosphate, asymmetric dimethylarginine (ADMA), and parathyroid hormone (PTH) were observed in the present SNx rats without LVH. In the present study, the NaCl-loaded SNx (SNx + NaCl) rats were characterized by significant LVH and hypertension with aggravated values of all the parameters. We further confirmed that glomerular sclerosis, tubulointerstitial fibrosis, and inflammatory cell infiltration into the tubulointerstitial area, observed in the SNx rats, were more severely caused in the SNx + NaCl rats. In addition, plasma interleukin-6 (IL-6) levels in the SNx + NaCl rats were significantly increased compared to those in the SNx rats. These findings indicated that NaCl-loaded SNx rats developed LVH and hypertension, which were accompanied with increased plasma levels of PTH, creatinine, inorganic phosphorus, ADMA, and IL-6. Thus, these results suggest that inflammation as well as endothelial dysfunction would be correlated with LVH as non-traditional risk factors at the early stage in the present renal failure model.
authors.affiliation: Product Research Department, Chugai Pharmaceutical Co., LTD.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Moriguchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Yogo
authors.forename: Ken
authors.initials: K
authors.lastname: Aizawa
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Serizawa
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Tashiro
authors.forename: Keigo
authors.initials: K
authors.lastname: Yorozu
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Ishizuka
authors.forename: Sadahiro
authors.initials: S
authors.lastname: Iwabuchi
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Kitamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000032:analysis; D003404:Creatinine / Q000032:analysis; D004195:Disease Models, Animal; D005355:Fibrosis; D006973:Hypertension / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D007249:Inflammation / Q000150:complications; D015850:Interleukin-6 / Q000096:biosynthesis; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects; D010281:Parathyroid Hormone / Q000096:biosynthesis; D010710:Phosphates / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D012598:Sclerosis; D012965:Sodium Chloride / Q000009:adverse effects*
chemical_list: D015850:Interleukin-6; D010281:Parathyroid Hormone; D010710:Phosphates; D012965:Sodium Chloride; C018524:N,N-dimethylarginine; D001120:Arginine; D003404:Creatinine