title: 8-Carbon oxylipins inhibit germination and growth, and stimulate aerial conidiation in Aspergillus nidulans.
abstract: Germination of Aspergillus nidulans conidia in liquid cultures was progressively inhibited at inoculum loads above 1×10(5)conidiamL(-1). High conidial densities also inhibited growth of neighbouring mycelia. The eight-carbon oxylipin 1-octen-3-ol was identified as the main inhibitor in a fraction also containing 3-octanone and 3-octanol. These three oxylipins also increased the conidiation rate of dark-grown surface cultures, but had no effect on liquid cultures. 3-octanone was the most conidiogenic compound. The action of 3-octanone required functional forms of developmental activators fluG, flbB-D and brlA, and was not additive to the conidiogenic effect of stress stimuli such as osmotic stress or carbon starvation. Oxylipins were produced shortly after hyphae made contact with the atmosphere and were most effective on aerial mycelia, indicating that they perform their signalling function in the gas phase.
authors.affiliation: Department of Applied Chemistry, Faculty of Chemistry, University of the Basque Country, Manuel de Lardizabal 3, 20018 Donostia-San Sebastian, Spain.
authors.forename: Erika
authors.initials: E
authors.lastname: Herrero-Garcia
authors.forename: Aitor
authors.initials: A
authors.lastname: Garzia
authors.forename: Shandra
authors.initials: S
authors.lastname: Cordobés
authors.forename: Eduardo A
authors.initials: EA
authors.lastname: Espeso
authors.forename: Unai
authors.initials: U
authors.lastname: Ugalde
mesh_terms: D001233:Aspergillus nidulans / Q000187:drug effects* / Q000254:growth & development; D025301:Hyphae / Q000187:drug effects / Q000254:growth & development; D007659:Ketones / Q000737:chemistry; D000442:Octanols / Q000737:chemistry; D054883:Oxylipins / Q000737:chemistry*; D013172:Spores, Fungal / Q000187:drug effects* / Q000254:growth & development
chemical_list: D007659:Ketones; D000442:Octanols; D054883:Oxylipins; C017582:3-octanone; C038844:1-octen-3-ol