title: Acute liver failure in children.
abstract: The management of children with acute liver failure mandates a multidisciplinary approach and intense monitoring. In recent years, considerable progress has been made in developing specific and supportive medical measures, but clinical studies have mainly concerned adult patients. There are no specific medical therapies, except for a few metabolic diseases presenting with acute liver failure. Liver transplantation still remains the only definitive therapy in most instances. Recent clinical studies suggest that hepatocyte transplantation may be useful for bridging patients to liver transplantation, for providing metabolic support during liver failure and for replacing liver transplantation in certain metabolic liver diseases.
authors.affiliation: Neonatal, Pediatric Intensive Care Unit, Department of Pediatrics, AP-HP, Bicêtre Hospital, Paris 11-Sud University, 78, avenue Général-Leclerc, 94275 Le Kremlin-Bicêtre, France. denis.devictor@bct.aphp.fr
authors.forename: Denis
authors.initials: D
authors.lastname: Devictor
authors.forename: Pierre
authors.initials: P
authors.lastname: Tissieres
authors.forename: Mickael
authors.initials: M
authors.lastname: Afanetti
authors.forename: Dominique
authors.initials: D
authors.lastname: Debray
mesh_terms: D002648:Child; D002779:Cholestasis / Q000150:complications; D000075202:Contraindications; D004750:Enteral Nutrition; D005112:Extracorporeal Circulation; D005693:Galactosemias / Q000150:complications; D006333:Heart Failure / Q000517:prevention & control; D006432:Hemochromatosis / Q000150:complications; D006470:Hemorrhage / Q000209:etiology / Q000628:therapy; D006501:Hepatic Encephalopathy / Q000209:etiology; D019693:Hepatitis, Autoimmune / Q000150:complications; D006527:Hepatolenticular Degeneration / Q000150:complications; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D019586:Intracranial Hypertension / Q000517:prevention & control; D007565:Jaundice / Q000209:etiology; D017114:Liver Failure, Acute / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D008111:Liver Function Tests; D016031:Liver Transplantation; D019164:Liver, Artificial; D008661:Metabolism, Inborn Errors / Q000150:complications; D051437:Renal Insufficiency / Q000517:prevention & control; D012131:Respiratory Insufficiency / Q000517:prevention & control; D043202:Steroid Metabolism, Inborn Errors; D020176:Tyrosinemias / Q000150:complications