title: The status of EGFR CA SSR1 is a potential prognostic factor for patients with oral squamous cell carcinoma.
abstract: The EGFR is an oncogene known to be involved in the development and progression of many cancers. It has been reported that the expression of EGFR and EGFR CA simple sequence repeat 1 (CA SSR1) repeat numbers in tumors can be useful prognostic factors in several cancer types. The objective of the present study was to analyze whether the EGFR polymorphism can be a useful prognostic factor in OSCC in the Taiwanese population. OSCC tissues were collected from 47 patients by surgical excision. The genotyping of EGFR were performed with the ABI Prism 3100 Genetic Analyzer. OSCC patients had a tendency toward an allelic imbalance of CA SSR1. The results also suggested that OSCC patients who were homozygous for CA SSR1 had a poorer prognosis than those who were heterozygous (P<0.001). Besides, patients with an allelic imbalance of CA SSR1 had significantly lower overall and disease free survival rates than those without, using the Kaplan-Meier method (P<0.001). This suggests that the status of CA SSR1 has the potential to be a useful prognosis factor in OSCC.
authors.affiliation: Department of Biology, National Changhua University of Education, Changhua City, Taiwan.
authors.forename: Yan-Liang
authors.initials: YL
authors.lastname: Lin
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Wang
authors.forename: Jin-Ching
authors.initials: JC
authors.lastname: Lin
authors.forename: Yong-Kie
authors.initials: YK
authors.lastname: Wong
authors.forename: Yi-Chih
authors.initials: YC
authors.lastname: Chien
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D018773:Genes, erbB-1 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D011110:Polymorphism, Genetic; D011379:Prognosis; D013624:Taiwan