title: Microskin autografting in the treatment of burns over 70% of total body surface area: 14 years of clinical experience.
abstract: Despite the fact that early excision and grafting have significantly improved burn outcomes, the management of severely burned patients whose burn size exceeds 70% total body surface area (TBSA) still represents a big challenge for burn surgeons all over the world. During the period of 1997-2010 at our centre, aggressive excision and microskin autografting were performed in 63 severely burned patients. Their burn sizes ranged from 70% to 98% TBSA with a mean of 84.9%. The average full-thickness burn was 66.3% (range, 29-94%). Thirty patients had concomitant inhalation injury. Two to 7 days after burn, these patients underwent aggressive excisions ranging from 25% to 60% TBSA and transplantation of microskin autograft overlaid with allograft. The ratios of donor-site to recipient-site surface area were between 1:6 and 1:18. Signs of epithelialization were shown within 35-55 days. The wound healing rate was 74.9% (176/235), with 51.1% of cases (120/235) healing completely and 23.8% (56/235) improving. Microskin autografting yielded an overall survival rate of 63.5%; only 23 patients died. Our clinical experience in using the microskin autografting for burn coverage suggests that the technique is very effective in covering extensive burns, and that it is particularly useful when graft donor sites are very limited due to its high utilization rate of donor site. The factors affecting the outcome of microskin autografting are discussed herein.
authors.affiliation: Department of Burns, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, PR China. okcxl@126.com
authors.forename: Xu-Lin
authors.initials: XL
authors.lastname: Chen
authors.forename: Xun
authors.initials: X
authors.lastname: Liang
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Sheng
authors.initials: S
authors.lastname: Liu
authors.forename: Yong-Jie
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001830:Body Surface Area; D002056:Burns / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016038:Skin Transplantation / Q000379:methods*; D015996:Survival Rate; D014182:Transplantation, Autologous; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult