title: Endothelial shear stress from large-scale blood flow simulations.
abstract: We discuss the optimal evaluation of endothelial shear stress for real-life case studies based on anatomic data acquisition. The fluid dynamic simulations require smoothing of the geometric dataset to avoid major artefacts in the flow patterns, especially in the proximity of bifurcations. A systematic series of simulations at different corrugation levels shows that, below a smoothing length of about 0.5 mm, the numerical data are insensitive to further smoothing.
authors.affiliation: Istituto per i Processi Chimico-Fisici, Consiglio Nazionale delle Ricerche, Rome, Italy. simone.melchionna@gmail.com
authors.forename: Simone
authors.initials: S
authors.lastname: Melchionna
authors.forename: Efthimios
authors.initials: E
authors.lastname: Kaxiras
authors.forename: Massimo
authors.initials: M
authors.lastname: Bernaschi
authors.forename: Sauro
authors.initials: S
authors.lastname: Succi
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003198:Computer Simulation; D003331:Coronary Vessels / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D033081:Shear Strength / Q000502:physiology*