title: P53, Bcl-2 expression and cell proliferation in benign breast lesions.
abstract: The role of proliferation-related markers on breast cancer pathogenesis has been only occasionally investigated. The immunocytochemical expression of P53 and Bcl-2 (using PAb1801 and anti-bcl-2 monoclonal antibodies) and cell proliferation (evaluated as the H-3-thymidine labeling index [H-3-dT LI]) were determined on 62 benign breast lesions at different risk. Accumulation of the P53 protein was never observed; Bcl-2 was detected in 50% of cases and it was unrelated to biologic and clinicopathologic features. Median H-3-dT LI was about three times lower than that observed on large series of invasive breast cancer. It was only slightly higher in lesions from patients younger than 35 years or with a positive family history than in those under 35 or with a negative family history and appeared unrelated to histology or risk classification. Such findings indicate that the investigated biomarkers fail to identify women at increased risk for breast cancer.
authors.affiliation: IST NAZL STUDIO & CURA TUMORI,ONCOL SPERIMENTALE C,I-20133 MILAN,ITALY. OSPED ONCOL A BUSINCO,SERV ANAT & ISTOL PATOL,I-09126 CAGLIARI,ITALY.
authors.forename: L
authors.initials: L
authors.lastname: Dimartino
authors.forename: E
authors.initials: E
authors.lastname: Benini
authors.forename: A
authors.initials: A
authors.lastname: Faranda
authors.forename: B
authors.initials: B
authors.lastname: Demontis
authors.forename: G
authors.initials: G
authors.lastname: Murenu
authors.forename: A
authors.initials: A
authors.lastname: Ferreli
authors.forename: M
authors.initials: M
authors.lastname: Daidone
authors.forename: R
authors.initials: R
authors.lastname: Silvestrtni