title: Comparing a transrectal ultrasound-guided with a cystoscopy-guided botulinum toxin a injection in treating detrusor external sphincter dyssynergia in spinal cord injury.
abstract: OBJECTIVE
  The aim of this study was to compare the results of a transrectal ultrasound-guided botulinum toxin injection with those of a cystoscopy-guided method to the external urethral sphincter in treating detrusor external sphincter dyssynergia.
  
  
  METHODS
  A total of 18 suprasacral spinal cord-injured patients with detrusor external sphincter dyssynergia were included in the present study. A single dose of 100 IU botulinum toxin A was applied into the external urethral sphincter via a transrectal ultrasound-guided transperineal route. We retrospectively compared the outcome measurements with 20 suprasacral spinal cord-injured patients previously treated with the same dose of botulinum toxin through a cystoscopy-guided procedure.
  
  
  RESULTS
  There were significant reductions in integrated electromyography and urethral pressure but not in detrusor pressure and leak point pressure after treatment. Postvoiding residuals were significantly decreased in the first, second, and third months in the cystoscopy group and in the first and second months in the transrectal ultrasound group. There were no significant differences between the groups in all of the outcome measures.
  
  
  CONCLUSIONS
  This study demonstrates that transrectal ultrasound-guided transperineal botulinum toxin injection may be an alternative for a cystoscopy-guided injection. This alternative procedure provides clinicians with an innovative and less invasive method that is performed without requiring anesthesia or cystoscopy.
authors.affiliation: Department of Urology, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Sung-Lang
authors.initials: SL
authors.lastname: Chen
authors.forename: Liu-Ing
authors.initials: LI
authors.lastname: Bih
authors.forename: Gin-Den
authors.initials: GD
authors.lastname: Chen
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Huang
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: You
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D003558:Cystoscopy; D004576:Electromyography; D006801:Humans; D007267:Injections; D008297:Male; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D012189:Retrospective Studies; D013119:Spinal Cord Injuries / Q000150:complications*; D018084:Ultrasonography, Interventional; D014521:Urethra / Q000000981:diagnostic imaging; D001750:Urinary Bladder, Neurogenic / Q000209:etiology / Q000628:therapy*; D016055:Urinary Retention / Q000209:etiology / Q000628:therapy; D014563:Urodynamics
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A