title: [Joint endoprosthesis pathology. Histopathological diagnostics and classification].
abstract: Prosthesis durability has steadily increased with high 10-year rates of 88-95%. However, four pathogenetic groups of diseases can decrease prosthesis durability: (1) periprosthetic wear particle disease (aseptic loosening) (2) bacterial infection (septic loosening) (3) periprosthetic ossification, and (4) arthrofibrosis. The histopathological "extended consensus classification of periprosthetic membranes" includes four types of membranes, arthrofibrosis, and osseous diseases of endoprosthetics: The four types of neosynovia are: wear particle-induced type (type I), mean prosthesis durability (MPD) in years 12.0; infectious type (type II), MPD 2.5; combined type (type III) MPD 4.2; and indeterminate type (type IV), MPD 5.5. Arthrofibrosis can be determined in three grades: grade 1 needs clinical information to be differentiated from a type IV membrane, and grades 2 & 3 can be diagnosed histopathologically. Periprosthetic ossification, osteopenia-induced fractures, and aseptic osteonecrosis can be histopathologically diagnosed safely with clinical information. The extended consensus classification of periprosthetic membranes may be a diagnostic groundwork for a future national endoprosthesis register.
authors.affiliation: Zentrum für Histologie, Zytologie und Molekulare Diagnostik Trier, Max-Planck-Str. 18 u. 20, 54296, Trier. krenn@patho-trier.de
authors.forename: V
authors.initials: V
authors.lastname: Krenn
authors.forename: L
authors.initials: L
authors.lastname: Morawietz
authors.forename: M
authors.initials: M
authors.lastname: Jakobs
authors.forename: H
authors.initials: H
authors.lastname: Kienapfel
authors.forename: R
authors.initials: R
authors.lastname: Ascherl
authors.forename: L
authors.initials: L
authors.lastname: Bause
authors.forename: H
authors.initials: H
authors.lastname: Kuhn
authors.forename: G
authors.initials: G
authors.lastname: Matziolis
authors.forename: M
authors.initials: M
authors.lastname: Skutek
authors.forename: T
authors.initials: T
authors.lastname: Gehrke
mesh_terms: D001424:Bacterial Infections / Q000473:pathology* / Q000601:surgery; D019544:Equipment Failure Analysis; D006622:Hip Prosthesis; D006801:Humans; D011475:Prosthesis Failure / Q000209:etiology*; D016459:Prosthesis-Related Infections / Q000473:pathology* / Q000601:surgery; D012086:Reoperation; D012307:Risk Factors; D000074402:Synovectomy; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000209:etiology / Q000473:pathology