title: [NT-Pro-BNP levels performance before and after reversion to sinus rhythm in patients with preserved ventricular function].
abstract: Our objective was to evaluate changes of N-terminal pro-BNP (NT-Pro-BNP) levels at baseline and after restoration to sinus rhythm in hemodynamic stable patients with lone atrial fibrillation (LAF) with preserved left ventricular function. NT-Pro-BNP levels were obtained before and after cardioversion in thirty hemodynamic stable patients with LAF and preserved left ventricular function. At baseline levels of NT-Pro BNP levels were significatively higher than a normal control group. NT-Pro-BNP levels decreased significantly following cardioversion from 529 (157-1763) to 318 (98-870) pg/ml, p < 0.0001. Decreasing of N-terminal pro-BNP concentrations was observed after any mode of cardioversion: electrical or pharmacologic, 345 (153-1151) pg/ml to 169 (86-407) pg/ml, p: 0.02 and from 1624 (541-4010) pg/ml to 856 (532-1160) pg/ml, p < 0.001, respectively. N-terminal pro-BNP decreasing was observed mainly in patients with length of LAF longer than 8 hours: 1289 (338-2103) to 410 (169-905) pg/ml, p < 0.001 but no difference was detected when such length was less than 8 hours: 274 (137-2300) to 286 (82-1440), p = NS. Our study showed that baseline levels of NT-pro-BNP decreased shortly after reversion of patients with LAF to sinus rhythm. This performance occurs predominantly in patients with LAF length of at least eight hours.
authors.affiliation: Unidad Coronaria, Hospital Alemán, Buenos Aires, Argentina. chiga@hospitalaleman.com.ar
authors.forename: Claudio
authors.initials: C
authors.lastname: Higa
authors.forename: Graciana
authors.initials: G
authors.lastname: Ciambrone
authors.forename: María Sol
authors.initials: MS
authors.lastname: Donato
authors.forename: Gimena
authors.initials: G
authors.lastname: Gambarte
authors.forename: Natalia
authors.initials: N
authors.lastname: Rizzo
authors.forename: Ana
authors.initials: A
authors.lastname: Escobar
authors.forename: Fedor
authors.initials: F
authors.lastname: Novo
authors.forename: Pablo
authors.initials: P
authors.lastname: Comignani
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011446:Prospective Studies; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain