title: Invadosome regulation by adhesion signaling.
abstract: Invadosomes are adhesive mechanosensory modules composed of a dense F-actin core surrounded by a ring of adhesion molecules and able to infiltrate compact tissue environment in physiological and pathological conditions. These structures comprise podosomes that are found in a variety of cells under physiological conditions and invadopodia in transformed or cancer cells. Invadosomes are regulated by extracellular matrix signals and are endowed with degradative machinery for extracellular matrix. The ability of extracellular matrix signals to orchestrate the building, dynamics, and function of invadosomes is based on mechano-chemical integrin outside-in signaling and requires integrin cross-talk. This review highlights recent findings that place Src as an inducer and PKC as an amplifier in the assembly of integrin stimulated invadosome through mechanotransduction and polarized endo/exocytic trafficking pathways for key proteolytic and enzymatic activities in a temporally and spatially confined manner.
authors.affiliation: INSERM U823, Institut Albert Bonniot, 38706 La Tronche Cedex, Grenoble, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Destaing
authors.forename: Marc R
authors.initials: MR
authors.lastname: Block
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Planus
authors.forename: Corinne
authors.initials: C
authors.lastname: Albiges-Rizo
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D040542:Mechanotransduction, Cellular; D011493:Protein Kinase C / Q000378:metabolism; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000378:metabolism
chemical_list: D000199:Actins; D015815:Cell Adhesion Molecules; D016023:Integrins; D016392:Proto-Oncogene Proteins pp60(c-src); D011493:Protein Kinase C