title: [Expression of estrogen sulfotransferase in the mammary gland of hypertrophic breast and its significance].
abstract: OBJECTIVE
  To investigate the expression of estrogen sulfotransferase (EST) in the mammary gland of hypertrophic breast and its significance.
  
  
  METHODS
  EST expression in the mammary gland was detected by EnVision two step method of immunohistochemistry in 15 cases with normal breasts and 32 cases with hypertrophic breasts, including 19 gland-associated cases and 13 fat-associated cases.
  
  
  RESULTS
  The positive expression rate of EST in mammary gland was 34.4% (11/32) in hypertrophic group and 93.3% (14/15) in normal group, showing a significant difference between the two groups (P < 0.01). The positive expression rate of EST was 10.5% (2/19) in gland-associated group and 69.2% (9/ 13) in fat-associated group, showing a significant difference between the two groups (P < 0.01).
  
  
  CONCLUSIONS
  Decrease or deletion of EST in the mammary gland may be related to the development of hypertrophic breast, especially gland-associated hypertrophic breast.
authors.affiliation: Department of Plastic Surgery, Union Hospital of Tongji Medical College, Huazhong Science and Technology University, Wuhan 430022, China. yangyq3y@yahoo.com.cn
authors.forename: Yan-qing
authors.initials: YQ
authors.lastname: Yang
authors.forename: Jia-ming
authors.initials: JM
authors.lastname: Sun
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.forename: Rui-rui
authors.initials: RR
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Guo
mesh_terms: D000328:Adult; D001940:Breast / Q000002:abnormalities / Q000201:enzymology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000201:enzymology*; D042361:Mammary Glands, Human / Q000201:enzymology*; D008875:Middle Aged; D015238:Sulfotransferases / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015238:Sulfotransferases; C020122:estrone sulfotransferase