title: A highly enantio- and diastereoselective molybdenum-catalyzed asymmetric allylic alkylation of cyanoesters.
abstract: An efficient molybdenum-catalyzed asymmetric allylic alkylation (Mo-AAA) of cyanoester nucleophiles is reported. A number of highly functionalized branched cyanoesters containing a quaternary carbon stereocenter with a vicinal tertiary stereocenter are obtained. This method generates a number of functionalized cyanoesters in excellent yield and chemoselectivity in good to excellent diastereoselectivity and enantioselectivity.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@stanford.edu
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: John R
authors.initials: JR
authors.lastname: Miller
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Hoffman