title: Access to macrocycles with an endo aryl ether and an endo aryl-aryl bond, development and application.
abstract: Macrocyclization methodologies allowing access to macrocycles having an endo aryl ether and an endo aryl-aryl bond, especially those based on an intramolecular S(N)Ar reaction and the Suzuki-Miyaura reaction, are summarized. Total synthesis of complestatin, a bis-macrocyclic natural product, featuring these two technologies are presented.
authors.affiliation: Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu
mesh_terms: D002384:Catalysis; D002733:Chlorophenols / Q000138:chemical synthesis* / Q000737:chemistry*; D003170:Complement Pathway, Alternative / Q000187:drug effects; D004987:Ethers / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D002733:Chlorophenols; D004987:Ethers; D006571:Heterocyclic Compounds; D010456:Peptides, Cyclic; C023490:complestatin