title: In vitro studies of cellular response to DNA damage induced by boron neutron capture therapy.
abstract: The aim of these studies was to evaluate the mechanisms of cellular response to DNA damage induced by BNCT. Thyroid carcinoma cells were incubated with (10)BPA or (10)BOPP and irradiated with thermal neutrons. The surviving fraction, the cell cycle distribution and the expression of p53 and Ku70 were analyzed. Different cellular responses were observed for each irradiated group. The decrease of Ku70 in the neutrons +BOPP group could play a role in the increase of sensitization to radiation.
authors.affiliation: Department of Radiobiology, National Atomic Energy Commission (CNEA), San Martin, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Perona
authors.forename: O
authors.initials: O
authors.lastname: Pontiggia
authors.forename: M
authors.initials: M
authors.lastname: Carpano
authors.forename: L
authors.initials: L
authors.lastname: Thomasz
authors.forename: S
authors.initials: S
authors.lastname: Thorp
authors.forename: E
authors.initials: E
authors.lastname: Pozzi
authors.forename: M
authors.initials: M
authors.lastname: Simian
authors.forename: S
authors.initials: S
authors.lastname: Kahl
authors.forename: G
authors.initials: G
authors.lastname: Juvenal
authors.forename: M
authors.initials: M
authors.lastname: Pisarev
authors.forename: A
authors.initials: A
authors.lastname: Dagrosa
mesh_terms: D016754:Boron Neutron Capture Therapy; D002453:Cell Cycle; D004249:DNA Damage; D006801:Humans; D066298:In Vitro Techniques; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy*