title: Impact of portal venous hemodynamics on indices of liver function and graft regeneration after right lobe living donor liver transplantation.
abstract: The aim of this study was to evaluate the effects of portal hemodynamics on indices of liver function and graft regeneration in patients after adult right lobe living donor liver transplantation (R-LDLT). Sixty-four patients who underwent R-LDLT and had an uneventful postoperative course were enrolled in this study. The contribution of portal flow was greater to the recipient grafts versus the donor livers (90.74% versus 69.12%, P < 0.0001). Portal flow variations decreased significantly during the first 10 days after R-LDLT (P < 0.0001); variations in the hepatic arterial flow were more constant during this period (P = 0.812). The mean portal venous pressure (PVP) before recipient hepatectomy (the initial PVP) was 23.1 ± 4.0 mm Hg; the mean PVP after reperfusion (the final PVP) was 15.0 ± 4.3 mm Hg (P < 0.0001). Furthermore, the mean hepatic portal venous gradient (ie, PVP - central venous pressure) before recipient hepatectomy was 17.1 ± 4.3 mm Hg; it decreased to 10.6 ± 4.5 mm Hg after reperfusion (P < 0.0001). These findings suggest that after graft reperfusion, the vascular resistance of the hepatic parenchyma decreased, and there was an associated mild decrease in the portal hypertension. Multiple regression analysis indicated that PVPs correlated significantly with indices of liver function after living donor liver transplantation (P < 0.05). Patients were separated into 4 groups according to their PVP values: group A (initial PVP ≥ 23 mm Hg, final PVP ≥ 15 mm Hg), group B (initial PVP < 23 mm Hg, final PVP ≥ 15 mm Hg), group C (initial PVP ≥ 23 mm Hg, final PVP < 15 mm Hg), and group D (initial PVP < 23 mm Hg, final PVP < 15 mm Hg). Immediately after R-LDLT, the peak values for aspartate aminotransferase, alanine aminotransferase, the international normalized ratio and the average ascites production varied appreciably in these groups. The regeneration rate of the liver graft 3 months after R-LDLT was significantly greater in group A versus the other groups. In conclusion, PVP is a significant hemodynamic factor that influences the functional status of the liver and graft regeneration after R-LDLT.
authors.affiliation: Division of Liver and Transplantation Surgery, Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
authors.forename: Ting-Jung
authors.initials: TJ
authors.lastname: Wu
authors.forename: Divya
authors.initials: D
authors.lastname: Dahiya
authors.forename: Ching-Sung
authors.initials: CS
authors.lastname: Lee
authors.forename: Chen-Fang
authors.initials: CF
authors.lastname: Lee
authors.forename: Hong-Shiue
authors.initials: HS
authors.lastname: Chou
authors.forename: Kun-Ming
authors.initials: KM
authors.lastname: Chan
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Lee
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D005260:Female; D006085:Graft Survival; D006439:Hemodynamics; D006498:Hepatectomy / Q000379:methods; D006499:Hepatic Artery / Q000473:pathology; D006801:Humans; D008099:Liver / Q000502:physiology*; D008115:Liver Regeneration; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D017082:Portal Pressure; D011169:Portal Vein / Q000473:pathology; D011184:Postoperative Period; D013345:Subarachnoid Hemorrhage; D014184:Transplantation, Homologous / Q000379:methods
chemical_list: D000017:ABO Blood-Group System