title: Regulation of gene expression in human tendinopathy.
abstract: BACKGROUND
  Chronic tendon injuries, also known as tendinopathies, are common among professional and recreational athletes. These injuries result in a significant amount of morbidity and health care expenditure, yet little is known about the molecular mechanisms leading to tendinopathy.
  
  
  METHODS
  We have used histological evaluation and molecular profiling to determine gene expression changes in 23 human patients undergoing surgical procedures for the treatment of chronic tendinopathy.
  
  
  RESULTS
  Diseased tendons exhibit altered extracellular matrix, fiber disorientation, increased cellular content and vasculature, and the absence of inflammatory cells. Global gene expression profiling identified 983 transcripts with significantly different expression patterns in the diseased tendons. Global pathway analysis further suggested altered expression of extracellular matrix proteins and the lack of an appreciable inflammatory response.
  
  
  CONCLUSIONS
  Identification of the pathways and genes that are differentially regulated in tendinopathy samples will contribute to our understanding of the disease and the development of novel therapeutics.
authors.affiliation: Tissue Repair, Pfizer Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA. Scott.Jelinsky@pfizer.com
authors.forename: Scott A
authors.initials: SA
authors.lastname: Jelinsky
authors.forename: Scott A
authors.initials: SA
authors.lastname: Rodeo
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Lawrence V
authors.initials: LV
authors.lastname: Gulotta
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Archambault
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Seeherman
mesh_terms: D000328:Adult; D000368:Aged; D001265:Athletic Injuries / Q000235:genetics* / Q000503:physiopathology / Q000601:surgery; D002908:Chronic Disease; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013708:Tendon Injuries / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D013710:Tendons / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D016326:Extracellular Matrix Proteins