title: Steroid-hormone production and receptors in relation to ki-67, p53, s-phase fraction and ploidy in epithelial ovarian-tumors.
abstract: In this investigation, the in vitro production of progesterone and estradiol in ovarian tissues was studied for the first time in relation to the immunohistochemical expression of steroid hormone receptors, Ki-67, p53, DNA ploidy and S-phase fraction. Ovarian tissue from 44 women was examined. Steroid receptors were found more frequently in normal than in tumor ovaries. A substantial focal staining heterogeneity was demonstrated. Mucinous tumors were always progesterone receptor negative. Furthermore, the Ki-67 index was negatively correlated to the progesterone production of the tumor ovaries. Among the malignant tumors, all the high producers of progesterone expressing PR were low proliferating, diploid and p53-negative.
authors.affiliation: UMEA UNIV,DEPT PATHOL,S-90187 UMEA,SWEDEN. UMEA UNIV,DEPT GYNECOL ONCOL,S-90187 UMEA,SWEDEN. UMEA UNIV,DEPT OBSTET & GYNECOL,S-90187 UMEA,SWEDEN. KAROLINSKA INST,DEPT MED RADIAT BIOL,STOCKHOLM,SWEDEN.
authors.forename: M
authors.initials: M
authors.lastname: Ridderheim
authors.forename: B
authors.initials: B
authors.lastname: Tribukait
authors.forename: U
authors.initials: U
authors.lastname: Stendahl
authors.forename: T
authors.initials: T
authors.lastname: Backstrom
authors.forename: S
authors.initials: S
authors.lastname: Cajander