title: fMRI brain mapping during motion capture and FES induced motor tasks: signal to noise ratio assessment.
abstract: Functional Electrical Stimulation (FES) is a well known clinical rehabilitation procedure, however the neural mechanisms that underlie this treatment at Central Nervous System (CNS) level are still not completely understood. Functional magnetic resonance imaging (fMRI) is a suitable tool to investigate effects of rehabilitative treatments on brain plasticity. Moreover, monitoring the effective executed movement is needed to correctly interpret activation maps, most of all in neurological patients where required motor tasks could be only partially accomplished. The proposed experimental set-up includes a 1.5 T fMRI scanner, a motion capture system to acquire kinematic data, and an electro-stimulation device. The introduction of metallic devices and of stimulation current in the MRI room could affect fMRI acquisitions so as to prevent a reliable activation maps analysis. What we are interested in is that the Blood Oxygenation Level Dependent (BOLD) signal, marker of neural activity, could be detected within a given experimental condition and set-up. In this paper we assess temporal Signal to Noise Ratio (SNR) as image quality index. BOLD signal change is about 1-2% as revealed by a 1.5 T scanner. This work demonstrates that, with this innovative set-up, in the main cortical sensorimotor regions 1% BOLD signal change can be detected at least in the 93% of the sub-volumes, and almost 100% of the sub-volumes are suitable for 2% signal change detection. The integrated experimental set-up will therefore allows to detect FES induced movements fMRI maps simultaneously with kinematic acquisitions so as to investigate FES-based rehabilitation treatments contribution at CNS level.
authors.affiliation: Politecnico di Milano, NearLab, Bioengineering Department, Via G. Colombo 40, Milano, Italy. marta.gandolla@mail.polimi.it
authors.forename: Marta
authors.initials: M
authors.lastname: Gandolla
authors.forename: Simona
authors.initials: S
authors.lastname: Ferrante
authors.forename: Claudia
authors.initials: C
authors.lastname: Casellato
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Ferrigno
authors.forename: Franco
authors.initials: F
authors.lastname: Molteni
authors.forename: Alberto
authors.initials: A
authors.lastname: Martegani
authors.forename: Tiziano
authors.initials: T
authors.lastname: Frattini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pedrocchi
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D046690:Deep Brain Stimulation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009043:Motor Activity; D015203:Reproducibility of Results; D059629:Signal-To-Noise Ratio; D013997:Time Factors