title: Highly potent activity of (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in animal models of Parkinson's disease.
abstract: (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound 1 resulted in nearly full recovery of the locomotor and exploratory activities and was as effective as the comparator agent (levodopa). All eight stereoisomers of compound 1 have been synthesized and the influence of the absolute configuration on the antiparkinsonian activity of compound 1 was shown.
authors.affiliation: Russian Academy of Sciences, Novosibirsk, Russian Federation.
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Ardashov
authors.forename: Alla V
authors.initials: AV
authors.lastname: Pavlova
authors.forename: Irina V
authors.initials: IV
authors.lastname: Il'ina
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Morozova
authors.forename: Dina V
authors.initials: DV
authors.lastname: Korchagina
authors.forename: Elena V
authors.initials: EV
authors.lastname: Karpova
authors.forename: Konstantin P
authors.initials: KP
authors.lastname: Volcho
authors.forename: Tat'yana G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: Nariman F
authors.initials: NF
authors.lastname: Salakhutdinov
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D000978:Antiparkinson Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003511:Cyclohexanols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D018492:Dopamine Antagonists / Q000494:pharmacology; D004357:Drug Synergism; D006220:Haloperidol; D007980:Levodopa / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008968:Molecular Conformation; D009043:Motor Activity / Q000187:drug effects*; D009498:Neurotoxins / Q000494:pharmacology; D010300:Parkinson Disease / Q000188:drug therapy*; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: C560299:3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol; D000978:Antiparkinson Agents; D003511:Cyclohexanols; D018492:Dopamine Antagonists; D009498:Neurotoxins; D017981:Receptors, Neurotransmitter; D007980:Levodopa; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D006220:Haloperidol