title: The endocrine system and sarcopenia: potential therapeutic benefits.
abstract: Age related muscle loss, known as sarcopenia, is a major factor in disability, loss of mobility and quality of life in the elderly. There are many proposed mechanisms of age-related muscle loss that include the endocrine system. A variety of hormones regulate growth, development and metabolism throughout the lifespan. Hormone activity may change with age as a result of reduced hormone secretion or decreased tissue responsiveness. This review will focus on the complex interplay between the endocrine system, aging and skeletal muscle and will present possible benefits of therapeutic interventions for sarcopenia.
authors.affiliation: Stanford School of Medicine, Division of Nephrology, VA Palo Alto HCS-111R, Palo Alto, CA 94304, USA. kevin.mcintire@stanford.edu
authors.forename: Kevin L
authors.initials: KL
authors.lastname: McIntire
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Hoffman
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism; D000818:Animals; D019587:Dietary Supplements; D004703:Endocrine System / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D015444:Exercise; D005260:Female; D020249:Hormone Replacement Therapy; D006728:Hormones / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D055948:Sarcopenia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome; D014807:Vitamin D / Q000627:therapeutic use*
chemical_list: D006728:Hormones; D014807:Vitamin D