title: Differential effects of a murine monoclonal antibody reactive with the disialylgalactosyl residue on the growth of melanoma cells and T cell activation.
abstract: A murine monoclonal antibody, S2-566, was generated by immunization with a melanoma line, SK-MEL-28. Although AbS2-566 showed a similar reaction pattern with that of anti-GD3 mAbR24 in cell surface serology, it recognized a disialyl galactosyl structure not only in GD3 but in GT1a and GQ1b. The suppression of the growth of cultured melanoma cells by AbS2-566 was not obvious, in contrast with AbR24. However, the mitogenic effects of AbS2-566 on peripheral lymphocytes were observed showing similar kinetics to those of mAbR24, suggesting different signaling effects based on the different epitope structures.
authors.affiliation: NAGASAKI UNIV,SCH MED,DEPT ONCOL,NAGASAKI 852,JAPAN. MIE UNIV,SCH MED,DEPT INTERNAL MED 2,TSU,MIE 514,JAPAN.
authors.forename: H
authors.initials: H
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Shiku
authors.forename: K
authors.initials: K
authors.lastname: Furukawa