title: Drosophila as a model for antiviral immunity.
abstract: The fruit fly Drosophila melanogaster has been successfully used to study numerous biological processes including immune response. Flies are naturally infected with more than twenty RNA viruses making it a valid model organism to study host-pathogen interactions during viral infections. The Drosophila antiviral immunity includes RNA interference, activation of the JAK/STAT and other signaling cascades and other mechanisms such as autophagy and interactions with other microorganisms. Here we review Drosophila as an immunological research model as well as recent advances in the field of Drosophila antiviral immunity.
authors.affiliation: Jing-Huan Wang, Susanna Valanne, Mika Rämet, Institute of Medical Technology, University of Tampere, 33520 Tampere, Finland.
authors.forename: Jing-Huan
authors.initials: JH
authors.lastname: Wang
authors.forename: Susanna
authors.initials: S
authors.lastname: Valanne
authors.forename: Mika
authors.initials: M
authors.lastname: Rämet