title: Preclinical studies of gossypol in prostate carcinoma.
abstract: Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vive, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.
authors.affiliation: WAYNE STATE UNIV,SCH MED,DIV HEMATOL & ONCOL,DETROIT,MI 48201. COLUMBIA PRESBYTERIAN MED CTR,DIV MED ONCOL,NEW YORK,NY 10032. UNIV MICHIGAN,SCH MED,DIV HEMATOL & ONCOL,ANN ARBOR,MI 48109.
authors.forename: H
authors.initials: H
authors.lastname: Naik
authors.forename: D
authors.initials: D
authors.lastname: Petrylak
authors.forename: A
authors.initials: A
authors.lastname: Yagoda
authors.forename: J
authors.initials: J
authors.lastname: Lehr
authors.forename: A
authors.initials: A
authors.lastname: Akhtar
authors.forename: K
authors.initials: K
authors.lastname: Pienta