title: Child with Beckwith-Wiedemann syndrome born after assisted reproductive techniques to an human immunodeficiency virus serodiscordant couple.
abstract: OBJECTIVE
  To report a child with Beckwith-Wiedemann syndrome (BWS) born after assisted reproductive technology (ART) to an HIV serodiscordant couple.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  A child with BWS born after ART to an HIV serodiscordant couple.
  
  
  METHODS
  Assisted reproductive techniques.
  
  
  METHODS
  ART and HIV.
  
  
  RESULTS
  Since 2003, it has been suggested that there is an association between ART and BWS, which is a congenital overgrowth syndrome characterized by macrosomia, macroglossia, visceromegaly, umbilical and abdominal wall abnormalities, and an increased risk of developing embryonal tumors in childhood. It is a multigenic disorder resulting from genetic or epigenetic alterations of genes on chromosome 11p15. Methylation errors account for 50%-60% of sporadic cases and almost 100% of cases born after ART. We report the birth of a child diagnosed with BWS arising from an ART cycle to an HIV serodiscordant couple with no history of infertility. This case cannot constitute conclusive evidence but it raises various questions.
  
  
  CONCLUSIONS
  Assisted reproductive technology seems to be in the causal pathway but a male/female factor or an iatrogenic factor is also possible.
authors.affiliation: Service de Génétique Histologie Biologie du Développement et de la Reproduction (CECOS Franche-Comté Bourgogne), Hôpital Saint-Jacques, Besançon University Regional Hospital, Besançon, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Kuentz
authors.forename: Alphée
authors.initials: A
authors.lastname: Bailly
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Faure
authors.forename: Oxana
authors.initials: O
authors.lastname: Blagosklonov
authors.forename: Clotilde
authors.initials: C
authors.lastname: Amiot
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Bresson
authors.forename: Christophe
authors.initials: C
authors.lastname: Roux
mesh_terms: D000328:Adult; D001506:Beckwith-Wiedemann Syndrome / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006679:HIV Seropositivity / Q000097:blood / Q000150:complications / Q000175:diagnosis; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted