title: Passive multivariable temperature and conductivity RFID sensors for single-use biopharmaceutical manufacturing components.
abstract: Single-use biopharmaceutical manufacturing requires monitoring of critical manufacturing parameters. We have developed an approach for passive radio-frequency identification (RFID)-based sensing that converts ubiquitous passive 13.56 MHz RFID tags into inductively coupled sensors. We combine several measured parameters from the resonant sensor antenna with multivariate data analysis and deliver unique capability of multiparameter sensing and rejection of environmental interferences with a single sensor. We demonstrate here the integration of these RFID sensors into single-use biopharmaceutical manufacturing components. We have tested these sensors for over 500 h for measurements of temperature and solution conductivity with the accuracy of 0.1°C (32-48°C range) and accuracy of 0.3-2.9 mS/cm (0.5-230 mS/cm range). We further demonstrate simultaneous temperature and conductivity measurements with an individual RFID sensor with the accuracy of 0.2°C (5-60°C range) and accuracy of 0.9 mS/cm (0.5-183 mS/cm range). Developed RFID sensors provide several important features previously unavailable from other single-use sensing technologies such as the same sensor platform for measurements of physical, chemical, and biological parameters; multi-parameter monitoring with individual sensors; and simultaneous digital identification.
authors.affiliation: General Electric Global Research, Niskayuna, NY 12309, USA. potyrailo@crd.ge.com
authors.forename: Radislav A
authors.initials: RA
authors.lastname: Potyrailo
authors.forename: Timothy
authors.initials: T
authors.lastname: Wortley
authors.forename: Cheryl
authors.initials: C
authors.lastname: Surman
authors.forename: David
authors.initials: D
authors.lastname: Monk
authors.forename: William G
authors.initials: WG
authors.lastname: Morris
authors.forename: Mark
authors.initials: M
authors.lastname: Vincent
authors.forename: Rafael
authors.initials: R
authors.lastname: Diana
authors.forename: Vincent
authors.initials: V
authors.lastname: Pizzi
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Carter
authors.forename: Gerard
authors.initials: G
authors.lastname: Gach
authors.forename: Staffan
authors.initials: S
authors.lastname: Klensmeden
authors.forename: Hanno
authors.initials: H
authors.lastname: Ehring
mesh_terms: D001702:Biopharmaceutics / Q000295:instrumentation*; D004553:Electric Conductivity; D057233:Radio Frequency Identification Device; D013696:Temperature; D014894:Weights and Measures