title: The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma.
abstract: To investigate the prognostic significance of Survivin and Nectin-4 expression in breast carcinomas. Imprint smears were obtained from 140 breast carcinoma specimens and studied immunocytochemically for the expression of Survivin and Nectin-4. The results were correlated with several clinicopathological parameters, including five-year survival. Increased Survivin staining pattern correlated with increased grade (p < 0.0001), increased lymph node invasion (p < 0.0001), increased tumor size and reduced survival (p < 0.0001). Elevated Nectin-4 expression also correlated significantly with increased grade (p < 0.0001), increased tumor size (p < 0.0001) and reduced survival (p < 0.0001). In addition, Survivin and Nectin-4 staining patterns correlated strongly with one another (p < 0.0001). However, on multivariate analysis, neither Survivin nor Nectin-4 expression seemed to have an independent impact on survival in our study cases. The findings of our study suggest that increased expression of Survivin and Nectin-4 may indicate a worse prognosis in breast cancer patients. The exact implications of the expression of these markers in breast cancer prognosis and treatment remain to be clarified.
authors.affiliation: 1st Pathology Laboratory, Cytology Unit, Medical School, University of Athens, Athens, Greece. pathanas@cc.uoa.gr
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Athanassiadou
authors.forename: Efstratios
authors.initials: E
authors.lastname: Patsouris
authors.forename: Angelos
authors.initials: A
authors.lastname: Tsipis
authors.forename: Maria
authors.initials: M
authors.lastname: Gonidi
authors.forename: Pauline
authors.initials: P
authors.lastname: Athanassiadou
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism* / Q000601:surgery / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000601:surgery / Q000628:therapy; D015815:Cell Adhesion Molecules / Q000032:analysis* / Q000096:biosynthesis; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins / Q000032:analysis* / Q000096:biosynthesis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D000077022:Survivin; D000075983:Nectins
chemical_list: D015815:Cell Adhesion Molecules; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin; C107489:BIRC5 protein, human; C442228:NECTIN4 protein, human; D000075983:Nectins