title: Oxidative stress and anxiety-like symptoms related to withdrawal of passive cigarette smoke in mice: beneficial effects of pecan nut shells extract, a by-product of the nut industry.
abstract: The present study evaluated the role of pecan nut (Carya illinoensis) shells aqueous extract (AE) against oxidative damage induced by cigarette smoke exposure (CSE) and behavioral parameters of smoking withdrawal. Mice were passively exposed to cigarette smoke for 3 weeks (6, 10, and 14 cigarettes/day) and orally treated with AE (25 g/L). CSE induced lipid peroxidation in brain and red blood cells (RBC), increased catalase (CAT) activity in RBC, and decreased plasma ascorbic acid levels. AE prevented oxidative damage and increased antioxidant defenses of mice exposed to cigarette smoke. In addition, AE reduced the locomotor activity and anxiety symptoms induced by smoking withdrawal, and these behavioral parameters showed a positive correlation with RBC lipid peroxidation. Our results showed the beneficial effects of this by-product of the pecan industry, indicating its usefulness in smoking cessation.
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), RS, 97105-900, Brazil.
authors.forename: P
authors.initials: P
authors.lastname: Reckziegel
authors.forename: N
authors.initials: N
authors.lastname: Boufleur
authors.forename: R C S
authors.initials: RC
authors.lastname: Barcelos
authors.forename: D M
authors.initials: DM
authors.lastname: Benvegnú
authors.forename: C S
authors.initials: CS
authors.lastname: Pase
authors.forename: L G
authors.initials: LG
authors.lastname: Muller
authors.forename: A M
authors.initials: AM
authors.lastname: Teixeira
authors.forename: R
authors.initials: R
authors.lastname: Zanella
authors.forename: A C P
authors.initials: AC
authors.lastname: Prado
authors.forename: R
authors.initials: R
authors.lastname: Fett
authors.forename: J M
authors.initials: JM
authors.lastname: Block
authors.forename: M E
authors.initials: ME
authors.lastname: Burger
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001007:Anxiety / Q000139:chemically induced*; D001205:Ascorbic Acid / Q000097:blood; D031325:Carya; D002374:Catalase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D009754:Nuts; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D014028:Tobacco Smoke Pollution; D002374:Catalase; D001205:Ascorbic Acid