title: Occupational exposure to dusts and risk of renal cell carcinoma.
abstract: BACKGROUND
  Occupational exposures to dusts have generally been examined in relation to cancers of the respiratory system and have rarely been examined in relation to other cancers, such as renal cell carcinoma (RCC). Although previous epidemiological studies, though few, have shown certain dusts, such as asbestos, to increase renal cancer risk, the potential for other occupational dust exposures to cause kidney damage and/or cancer may exist. We investigated whether asbestos, as well as 20 other occupational dust exposures, were associated with RCC risk in a large European, multi-center, hospital-based renal case-control study.
  
  
  METHODS
  General occupational histories and job-specific questionnaires were reviewed by occupational hygienists for subject-specific information. Odds ratios (ORs) and 95% confidence intervals (95% CIs) between RCC risk and exposures were calculated using unconditional logistic regression.
  
  
  RESULTS
  Among participants ever exposed to dusts, significant associations were observed for glass fibres (OR: 2.1; 95% CI: 1.1-3.9), mineral wool fibres (OR: 2.5; 95% CI: 1.2-5.1), and brick dust (OR: 1.5; 95% CI: 1.0-2.4). Significant trends were also observed with exposure duration and cumulative exposure. No association between RCC risk and asbestos exposure was observed.
  
  
  CONCLUSIONS
  Results suggest that increased RCC risk may be associated with occupational exposure to specific types of dusts. Additional studies are needed to replicate and extend findings.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Occupational and Environmental Epidemiology Branch, 6120 Executive Boulevard, EPS 8121, Rockville, MD 20852, USA. karamis@mail.nih.gov
authors.forename: S
authors.initials: S
authors.lastname: Karami
authors.forename: P
authors.initials: P
authors.lastname: Boffetta
authors.forename: P S
authors.initials: PS
authors.lastname: Stewart
authors.forename: P
authors.initials: P
authors.lastname: Brennan
authors.forename: D
authors.initials: D
authors.lastname: Zaridze
authors.forename: V
authors.initials: V
authors.lastname: Matveev
authors.forename: V
authors.initials: V
authors.lastname: Janout
authors.forename: H
authors.initials: H
authors.lastname: Kollarova
authors.forename: V
authors.initials: V
authors.lastname: Bencko
authors.forename: M
authors.initials: M
authors.lastname: Navratilova
authors.forename: N
authors.initials: N
authors.lastname: Szeszenia-Dabrowska
authors.forename: D
authors.initials: D
authors.lastname: Mates
authors.forename: J
authors.initials: J
authors.lastname: Gromiec
authors.forename: A
authors.initials: A
authors.lastname: Slamova
authors.forename: W-H
authors.initials: WH
authors.lastname: Chow
authors.forename: N
authors.initials: N
authors.lastname: Rothman
authors.forename: L E
authors.initials: LE
authors.lastname: Moore
mesh_terms: D000368:Aged; D001194:Asbestos / Q000633:toxicity; D002273:Carcinogens; D002292:Carcinoma, Renal Cell / Q000453:epidemiology*; D016022:Case-Control Studies; D004391:Dust; D005060:Europe; D005061:Europe, Eastern; D005260:Female; D005898:Glass; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D019016:Mineral Fibers; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*; D018570:Risk Assessment
chemical_list: D002273:Carcinogens; D004391:Dust; D019016:Mineral Fibers; C009753:fiberglass; D001194:Asbestos