title: [A 33 year old woman with a six-year history of slight thoracic-abdominal pain].
abstract: We present a case of a benign hybrid nerve sheath tumor showing features of both cellular schwannoma and perineurioma.The patient was a 33 year-old female who presented with a 6 month history of pain in the thorax-lumbar region.Axial CT and MIR images showed and homogeneously enhancing solid oval mass involving the left paravertebra region in contact with the vertebral foramina T9-T11. Morphologically the tumor presented a well formed capsule and showed a uniform highly spindle cell proliferation. The spindle cells were arranged in whorls and intersecting fascicles with focal intervening sclerosis and relatively uniform cellularity with a prominent perivascular lymphocytic infiltrate. No cytological atypia, necrosis or mitoses were present. A second cell component was present composed of spindle-shaped cells with inconspicuous bipolar, pale, eosinophilic cytoplasm with oval nuclei. By immunohistochemistry there was a diffuse staining for S-100, and the elongated bipolar cells were EMA, Glut-1 and Claudin-1. To our knowledge this is the first reported case of a hybrid cellular schwannoma/perineurioma.
authors.affiliation: Departamento de Patología, Centro Médico ABC, México, D.F.
authors.forename: Mara A
authors.initials: MA
authors.lastname: Cárdenas-Escudero
authors.forename: Samuel
authors.initials: S
authors.lastname: Shuchleib-Chaba
authors.forename: Germán Walter
authors.initials: GW
authors.lastname: Muruchi-Garrón
authors.forename: Beatriz
authors.initials: B
authors.lastname: de León-Bojorge
authors.forename: Carlos
authors.initials: C
authors.lastname: Ortiz-Hidalgo
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D000328:Adult; D005260:Female; D006801:Humans; D018193:Neoplasms, Complex and Mixed / Q000150:complications / Q000473:pathology; D018317:Nerve Sheath Neoplasms / Q000150:complications / Q000473:pathology; D009442:Neurilemmoma / Q000150:complications* / Q000473:pathology; D010146:Pain / Q000209:etiology*; D012186:Retroperitoneal Neoplasms / Q000150:complications* / Q000473:pathology; D013122:Spinal Diseases / Q000209:etiology*