title: Hyperpolarized 129Xe lung MRI in spontaneously breathing mice with respiratory gated fast imaging and its application to pulmonary functional imaging.
abstract: In the present study, a balanced steady-state free precession pulse sequence combined with compressed sensing was applied to hyperpolarized (129) Xe lung imaging in spontaneously breathing mice. With the aid of fast imaging techniques, the temporal resolution was markedly improved in the resulting images. Using these protocols and respiratory gating, (129) Xe lung images in end-inspiratory and end-expiratory phases were obtained successfully. The application of these techniques for pulmonary functional imaging made it possible to simultaneously evaluate regional ventilation and gas exchange in the same animal. A comparative study between healthy and elastase-induced mouse models of emphysema showed abnormal ventilation as well as gas exchange in elastase-treated mice.
authors.affiliation: Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Imai
authors.forename: Atsuomi
authors.initials: A
authors.lastname: Kimura
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hori
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iguchi
authors.forename: Takuya
authors.initials: T
authors.lastname: Kitao
authors.forename: Emi
authors.initials: E
authors.lastname: Okubo
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ito
authors.forename: Toshio
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Fujiwara
mesh_terms: D000818:Animals; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D012119:Respiration; D013194:Staining and Labeling; D013997:Time Factors; D014978:Xenon / Q000378:metabolism*; D014979:Xenon Isotopes
chemical_list: D014979:Xenon Isotopes; D014978:Xenon