title: CCL5/RANTES gene polymorphisms in Slavonic patients with myocardial infarction.
abstract: Coronary artery inflammation is a critical process in the pathogenesis of myocardial infarction (MI). The chemokine CCL5/RANTES (regulated upon activation, normal T cells expressed and secreted) is expressed in advanced atherosclerotic lesions. Functional polymorphisms of the RANTES gene can, therefore, be involved in the pathogenesis of coronary artery disease. We examined the association of polymorphisms in the RANTES gene with myocardial infarction in Slavonic populations of Czech and Russian origin. A total of 467 post-MI patients and 337 control subjects were genotyped for RANTES promoter G-403A (rs2107538) and intron 1.1 T/C (rs2280789) variants by PCR-SSP. Both RANTES genotypes and allele frequencies did not differ between case and control groups. Haplotype-based analysis also failed to reveal an association between MI and investigated markers. Strong linkage disequilibrium was detected between particular RANTES alleles. The data do not support an association between RANTES G-403A polymorphism and MI, as reported previously.
authors.affiliation: Laboratory of Immunogenomics and Proteomics, Institute of Molecular and Translational Medicine, Palacky University and Faculty Hospital, Olomouc, Czech Republic. tereshchenko_ip@mail.ru
authors.forename: Irina P
authors.initials: IP
authors.lastname: Tereshchenko
authors.forename: Jana
authors.initials: J
authors.lastname: Petrkova
authors.forename: Mikhail I
authors.initials: MI
authors.lastname: Voevoda
authors.forename: Milos
authors.initials: M
authors.lastname: Taborsky
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Navratilova
authors.forename: Aida G
authors.initials: AG
authors.lastname: Romaschenko
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Maksimov
authors.forename: Frantisek
authors.initials: F
authors.lastname: Mrazek
authors.forename: Martin
authors.initials: M
authors.lastname: Petrek
mesh_terms: D000328:Adult; D000368:Aged; D018946:Chemokine CCL5 / Q000235:genetics* / Q000276:immunology*; D003324:Coronary Artery Disease / Q000235:genetics; D018153:Czech Republic; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012426:Russia; D044465:White People / Q000235:genetics*
chemical_list: D018946:Chemokine CCL5