title: Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell non-Hodgkin lymphoma.
abstract: In this study, we investigated Epstein Barr virus (EBV) presence, associated to proliferation and apoptosis proteins in pediatric B-cell Non-Hodgkin lymphoma (B-NHL). EBERs, Ki67, active caspase 3, Bax and Bcl2 were analyzed on B-NHL tissue from 40 patients. Forty percent showed EBV expression, significantly higher among patients ⩽10years (P=0.027), and associated with immunosuppression (P=0.020), but not associated apotosis markers. However, EBV was associated with a worse event-free survival (P=0.016), particularly under immunosuppression. Even though EBV did not seem to alter apoptotic pathways, it exhibited survival disadvantage and could be an important cofactor in B-cell lymphomagenesis in younger children.
authors.affiliation: Molecular Biology Laboratory, Pathology Division, Ricardo Gutiérrez Children's Hospital, Gallo 1330, Buenos Aires, Argentina. paola_chabay@yahoo.com.ar
authors.forename: P
authors.initials: P
authors.lastname: Chabay
authors.forename: J
authors.initials: J
authors.lastname: Lara
authors.forename: M
authors.initials: M
authors.lastname: Lorenzetti
authors.forename: P
authors.initials: P
authors.lastname: Cambra
authors.forename: G
authors.initials: G
authors.lastname: Acosta Haab
authors.forename: L
authors.initials: L
authors.lastname: Aversa
authors.forename: E
authors.initials: E
authors.lastname: De Matteo
authors.forename: M V
authors.initials: MV
authors.lastname: Preciado
mesh_terms: D002648:Child; D005260:Female; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016393:Lymphoma, B-Cell / Q000473:pathology* / Q000821:virology; D008297:Male; D016896:Treatment Outcome