title: Evaluation of the relative efficacy of autologous platelet-rich plasma in combination with β-tricalcium phosphate alloplast versus an alloplast alone in the treatment of human periodontal infrabony defects: a clinical and radiological study.
abstract: BACKGROUND
  Platelet-rich plasma (PRP) contains high levels of polypeptide growth factors that may enhance periodontal regeneration when combined with graft materials.
  
  
  OBJECTIVE
  The purpose of this study was to compare the efficacy of autologous PRP in combination with β-tricalcium phosphate (β-TCP) versus β-TCP alone in the treatment of human infrabony defects.
  
  
  METHODS
  Using a split-mouth design, 20 patients showing clinical evidence of almost identical bilateral infrabony defects were randomly selected. The right infrabony defects of the patient were designated as Group A and treated by the placement of β-TCP alone. The left infrabony defects of the same patient were designated as Group B and treated by the placement of PRP mixed with β-TCP. Clinical assessment of probing pocket depth and attachment level and radiographic evaluation of the defect depth were done preoperatively and at 12, 24 and 36 weeks postoperatively. The relative efficacy of two treatment modalities was evaluated using paired Student's t-test and the comparative evaluation between the two groups was done using independent Student's t-test.
  
  
  RESULTS
  Both the groups exhibited a highly significant reduction in probing pocket depth, gain in clinical attachment level and linear bone fill at the end of 36 weeks postoperatively. Comparative evaluation between the two study groups revealed a significant reduction in probing pocket depth (P = 0.036FNx01), mean gain in clinical attachment level (P = 0.042FNx01) and linear bone fill (P = 0.014FNx01) in Group B as compared to Group A.
  
  
  CONCLUSIONS
  Combination of PRP and β-TCP led to a significantly more favorable clinical and radiographic improvement in infrabony periodontal defects.
authors.affiliation: Department of Periodontics, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India. nalini_saini@rediffmail.com
authors.forename: Nalini
authors.initials: N
authors.lastname: Saini
authors.forename: Poonam
authors.initials: P
authors.lastname: Sikri
authors.forename: Harinder
authors.initials: H
authors.lastname: Gupta
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D016301:Alveolar Bone Loss / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D001672:Biocompatible Materials / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D053657:Platelet-Rich Plasma; D011859:Radiography; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D004338:Drug Combinations; C485817:beta-tricalcium phosphate