title: Chemical constituents of the leaves of Glochidion obliquum and their bioactivity.
abstract: A new flavonoid glycoside, globlin A (1), and eleven known compounds were isolated from methanolic extracts of the leaves of Glochidion obliquum. The structure of this new compound was established with a combination of 2D NMR techniques (COSY, NOESY, HMQC and HMBC) and HR-ESI-MS analyses. Chemical structures of the other known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literature. Some of the isolates were examined for their bioactivities. Among the tested compounds, rotundic acid (4) displayed significant cytotoxicity and anti-inflammatory activities.
authors.affiliation: Department of Chemistry, Vinh University, Vinh City, Nghean province, Vietnam.
authors.forename: Tran Dinh
authors.initials: TD
authors.lastname: Thang
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Chun-Shu
authors.initials: CS
authors.lastname: Yu
authors.forename: Yuh-Chiang
authors.initials: YC
authors.lastname: Shen
authors.forename: Le Thi Mai
authors.initials: le TM
authors.lastname: Hoa
authors.forename: Tran
authors.initials: T
authors.lastname: Van Thanh
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Yang
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D019665:Euphorbiaceae / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D019255:NADPH Oxidases / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis; D010851:Picrates / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D005419:Flavonoids; D016166:Free Radical Scavengers; D005609:Free Radicals; D006027:Glycosides; D010851:Picrates; C560806:globlin A; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D019255:NADPH Oxidases