title: Vascular endothelial growth-factor expression and angiogenesis in nonsmall cell lung carcinomas.
abstract: Vascular endothelial growth factor (VEGF), a secreted endothelial-specific growth factor, and microvessel density was examined in 204 primary non-small cell lung carcinomas. The expression of VEGF was evaluated by immunohistochemical staining using an anti-VEGF antibody. Positive staining was obtained in 125 out of 204 cases (61%). Tumor vascularity was quantitatively assessed by microvessel counting after staining with the endothelial-specific marker factor VIII. The mean microvessel count for all patients was 9.6+/-10.4. Expression of VEGF was closely associated with increment of microvessel density. Postoperative follow-up of patients demonstrated a trend that survival time of patients with VEGF-positive tumors was worse than that of patients with VEGF-negative tumors. In contrast, microvessel density was not a prognostic factor.
authors.affiliation: TARTU STATE UNIV,DEPT RADIOL & ONCOL,TARTU 202400,ESTONIA.
authors.forename: J
authors.initials: J
authors.lastname: Mattern
authors.forename: R
authors.initials: R
authors.lastname: Koomagi
authors.forename: M
authors.initials: M
authors.lastname: Volm