title: Time-dependent changes in the serum levels of prolactin, nesfatin-1 and ghrelin as a marker of epileptic attacks young male patients.
abstract: A relationship between hormones and seizures has been reported in animals and humans. Therefore, the purpose of this study was to investigate the association between serum levels of prolactin, nesfatin-1 and ghrelin measured different times after a seizure or non-epileptic event and compared with controls. The study included a total of 70 subjects, and of whom 18 patients had secondary generalized epilepsy (SGE), 16 patients had primary generalized epilepsy (PGE), 16 patients exhibited paroxysmal event (psychogenic) and 20 healthy males were control subjects. The first sample was taken within 5min of a seizure, with further samples taken after 1, 24, and 48h so long as the patient did not exhibit further clinically observable seizures; blood samples were taken once from control subjects. Prolactin was measured immediately using TOSOH Bioscience hormone assays. Nesfatin-1 and ghrelin peptides were measured using a commercial immunoassay kit. Patients suffering from focal epilepsy with secondary generalization and primary generalized epilepsy presented with significantly higher levels of serum prolactin and nesfatin-1 and lower ghrelin levels 5min, 1 and 24h after a seizure than patients presenting with paroxysmal events (psychogenic) and control subjects; the data were similar but not statistically significant after 48h. The present study suggests that increased serum prolactin and nesfatin-1 concentrations, decreased ghrelin concentrations could be used as markers to identify patients that have suffered a recent epileptic seizure or other paroxysmal event (psychogenic).
authors.affiliation: Firat University, Medical School, Department of Medical Biochemistry, Elazig, Turkey. saydin1@hotmail.com
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.forename: Ersel
authors.initials: E
authors.lastname: Dag
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ozkan
authors.forename: Ozgur
authors.initials: O
authors.lastname: Arslan
authors.forename: Guray
authors.initials: G
authors.lastname: Koc
authors.forename: Semai
authors.initials: S
authors.lastname: Bek
authors.forename: Serkan
authors.initials: S
authors.lastname: Kirbas
authors.forename: Tayfun
authors.initials: T
authors.lastname: Kasikci
authors.forename: Dilek
authors.initials: D
authors.lastname: Abasli
authors.forename: Zeki
authors.initials: Z
authors.lastname: Gokcil
authors.forename: Zeki
authors.initials: Z
authors.lastname: Odabasi
authors.forename: Zekiye
authors.initials: Z
authors.lastname: Catak
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000097:blood*; D004828:Epilepsies, Partial / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008074:Lipoproteins / Q000032:analysis; D008297:Male; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; D011388:Prolactin / Q000097:blood*; D014280:Triglycerides / Q000032:analysis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D054439:Ghrelin; D008074:Lipoproteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; D014280:Triglycerides; D011388:Prolactin