title: Analgesic and nonsteroidal anti-inflammatory use in relation to nonmelanoma skin cancer: a population-based case-control study.
abstract: BACKGROUND
  Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are potentially chemopreventive.
  
  
  OBJECTIVE
  We examined the relation between NSAID use and nonmelanoma skin cancer in a population-based case-control study.
  
  
  METHODS
  NSAID and analgesic use was analyzed in 1484 participants: 535 with squamous cell carcinoma (SCC), 487 with basal cell carcinoma (BCC), and 462 control subjects.
  
  
  RESULTS
  Use of NSAIDs, particularly aspirin, was associated with a reduced odds ratio (OR) of SCC, especially tumors positive for p53 (OR 0.29; 95% confidence interval 0.11-0.79) or with PTCH loss of heterozygosity (OR 0.35; 95% confidence interval 0.13-0.96). Although not considered a NSAID, decreased ORs of both basal cell carcinoma and SCC were observed in relation to use of paracetamol (acetaminophen). Risk of BCC was unrelated to NSAID use.
  
  
  CONCLUSIONS
  Self-reported drug use was a limitation.
  
  
  CONCLUSIONS
  This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.
authors.affiliation: Section of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
authors.forename: Dorothea C
authors.initials: DC
authors.lastname: Torti
authors.affiliation: Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island; Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island.
authors.forename: Brock C
authors.initials: BC
authors.lastname: Christensen
authors.affiliation: Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Storm
authors.affiliation: Novartis Farmaceutica SA, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Fortuny
authors.affiliation: Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire.
authors.forename: Ann E
authors.initials: AE
authors.lastname: Perry
authors.affiliation: Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, New Hampshire.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Zens
authors.affiliation: Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, New Hampshire; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
authors.forename: Therese
authors.initials: T
authors.lastname: Stukel
authors.affiliation: Section of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Spencer
authors.affiliation: Division of Epidemiology and Community Health, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
authors.forename: Heather H
authors.initials: HH
authors.lastname: Nelson
authors.affiliation: Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, New Hampshire. Electronic address: Margaret.Karagas@Dartmouth.edu.
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Karagas
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D016022:Case-Control Studies; D015331:Cohort Studies; D016001:Confidence Intervals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012016:Reference Values; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D001241:Aspirin