title: Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds.
abstract: Cellulose and sulfated cellulose fibrous meshes exhibiting robust structural and mechanical integrity in water were fabricated using a combination of electrospinning, thermal-mechanical annealing and chemical modifications. The sulfated fibrous mesh exhibited higher retention capacity for human recombinant bone morphogenetic protein-2 than the cellulose mesh, and the retained proteins remained biologically active for at least 7 days. The sulfated fibrous mesh also more readily supported the attachment and osteogenic differentiation of rat bone marrow stromal cells in the absence of osteogenic growth factors. These properties combined make the sulfated cellulose fibrous mesh a promising bone tissue engineering scaffold.
authors.affiliation: Department of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
authors.forename: Tera M
authors.initials: TM
authors.lastname: Filion
authors.forename: Artem
authors.initials: A
authors.lastname: Kutikov
authors.forename: Jie
authors.initials: J
authors.lastname: Song
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D055396:Bone Morphogenetic Protein 2 / Q000737:chemistry; D002454:Cell Differentiation; D002478:Cells, Cultured; D002482:Cellulose / Q000737:chemistry*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D051381:Rats; D011994:Recombinant Proteins / Q000737:chemistry; D017154:Stromal Cells / Q000166:cytology; D023822:Tissue Engineering
chemical_list: D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins; D002482:Cellulose