title: [Predictive value of some parameters of immune balance in preeclampsia].
abstract: The goal of our research was to reveal correlation between pro- and anti-inflammatory cytokines in preeclamptic women. The research was conducted on pregnant women with physiologic pregnancy and with preeclampsia. Parameters of immune system - pro-inflammatory cytokines (IL-2; TNF-α) and anti-inflammatory cytokine (IL-10) were measured in venous blood by ELISA. The increase of TNF-α and decrease of IL-10 in blood of pregnant women with pre-eclampsia after 20 weeks of gestation were observed; the content of IL-2 was in norm. The highest activation of inflammatory reactions was at the 20-28 weeks of gestation. It was found that women with preeclampsia had high levels of TNF- α in their blood. The increase of TNF- α has a prognostic significance.
authors.forename: M L
authors.initials: ML
authors.lastname: Tortladze
authors.forename: N P
authors.initials: NP
authors.lastname: Kintraia
authors.forename: T B
authors.initials: TB
authors.lastname: Sanikidze
mesh_terms: D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood / Q000276:immunology; D011263:Pregnancy Trimester, Third / Q000097:blood / Q000276:immunology; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10