title: French brain tumor database: 5-year histological results on 25 756 cases.
abstract: This work aimed to prospectively record all primary central nervous system tumor (PCNST) cases in France, for which histological diagnosis is available. The objectives were to (i) create a national registry and a network to perform epidemiological studies; (ii) implement clinical and basic research protocols; and (iii) harmonize the health care of patients affected by PCNST. For 5 years, 25 756 cases of newly diagnosed and histologically confirmed PCNST have been recorded. Histological diagnoses included glioma (48.9%), all other neuroepithelial tumors (5%), meningioma (28.8%), nerve sheath tumors (8.4%), lymphoma (3.2%) and others (5.7%). Cryopreservation was reported for 6018 PCNST specimens. Tumor resections (R) were performed in 78% cases, while biopsies accounted for 22%. Median age (MA), sex, percentage R and number of cryopreserved tumors were detailed for each histology; for example, out of 6053 glioblastomas (MA 63 years, male 59.4%, R 62%, 1611 were cryopreserved), and out of 37 atypical teratoid/rhabdoid tumors (MA 2 years, male 56.8%, R 94%, 17 were cryopreserved). This database or databank dedicated to PCNST cases contains detailed data on clinical, histological and other characteristics, such as the inclusion of data on cryopreserved specimens that are not available in other European registries. Therefore, this is a valuable resource that can be used for planning future epidemiological and clinical research.
authors.affiliation: Department of Pathology, Centre Hospitalier Universitaire, Hôpital Gui de Chauliac, Montpellier cedex, France. v-rigau@chu-montpellier.fr
authors.forename: Valérie
authors.initials: V
authors.lastname: Rigau
authors.forename: Sonia
authors.initials: S
authors.lastname: Zouaoui
authors.forename: Hélène
authors.initials: H
authors.lastname: Mathieu-Daudé
authors.forename: Amélie
authors.initials: A
authors.lastname: Darlix
authors.forename: Aurélie
authors.initials: A
authors.lastname: Maran
authors.forename: Brigitte
authors.initials: B
authors.lastname: Trétarre
authors.forename: Faiza
authors.initials: F
authors.lastname: Bessaoud
authors.forename: Fabienne
authors.initials: F
authors.lastname: Bauchet
authors.forename: Redha
authors.initials: R
authors.lastname: Attaoua
authors.forename: Pascale
authors.initials: P
authors.lastname: Fabbro-Peray
authors.forename: Michel
authors.initials: M
authors.lastname: Fabbro
authors.forename: Christine
authors.initials: C
authors.lastname: Kerr
authors.forename: Luc
authors.initials: L
authors.lastname: Taillandier
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
authors.forename: Dominique
authors.initials: D
authors.lastname: Figarella-Branger
authors.forename: Valérie
authors.initials: V
authors.lastname: Costes
authors.forename: Luc
authors.initials: L
authors.lastname: Bauchet
mesh_terms: D017677:Age Distribution; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D016208:Databases, Factual; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017678:Sex Distribution