title: Stereotactic body radiation therapy: scope of the literature.
abstract: Stereotactic body radiation therapy (SBRT) is derived from the techniques of stereotactic radiosurgery used to treat lesions in the brain and spine. It combines multiple finely collimated radiation beams and stereotaxy to deliver a high dose of radiation to an extracranial target in the body in a single dose or a few fractions. This review provides a broad overview of the current state of SBRT for solid malignant tumors. Reviewers identified a total of 124 relevant studies. To our knowledge, no published comparative studies address the relative effectiveness and safety of SBRT versus other forms of external-beam radiation therapy. Stereotactic body radiation therapy seems to be widely diffused as a treatment of various types of cancer, although most studies have focused only on its use for treating thoracic tumors. Comparative studies are needed to provide evidence that the theoretical advantages of SBRT over other radiation therapies actually occur in the clinical setting; this area is currently being studied in only 1 small trial.
authors.affiliation: ECRI Institute Evidence-based Practice Center, Plymouth Meeting, Pennsylvania 19462-1298, USA.
authors.forename: Kelley
authors.initials: K
authors.lastname: Tipton
authors.forename: Jason H
authors.initials: JH
authors.lastname: Launders
authors.forename: Rohit
authors.initials: R
authors.lastname: Inamdar
authors.forename: Curtis
authors.initials: C
authors.lastname: Miyamoto
authors.forename: Karen
authors.initials: K
authors.lastname: Schoelles
mesh_terms: D000465:Algorithms; D057186:Comparative Effectiveness Research; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D018579:Patient Selection; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012107:Research Design; D013899:Thoracic Neoplasms / Q000532:radiotherapy; D016896:Treatment Outcome