title: Effects of quercetin and chrysin on 2,3,7,8-tetrachlorodibenzo-p-dioxin induced hepatotoxicity in rats.
abstract: The objective of current study is to investigate the effects of the administration of chrysin (CH) and quercetin (Q) on rat liver in which oxidative and histological damage had been induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rats were randomly divided into six equal groups. TCDD was orally administered at the dose of 2 μg/kg/week, and Q and CH were orally administered at the doses of 20 mg/kg day and 50 mg/kg/day, respectively, by gavages dissolved in corn oil. The liver samples to be analyzed for the determination of oxidative and histological alternations were taken from rats at 60 days. The results indicated that although 2,3,7,8-TCDD significantly induced (P ≤ 0.01) lipid peroxidation (increase of MDA levels), it positively affected oxidant/antioxidant system (a decline in the levels of GSH, CAT, GSH-Px, and CuZn-SOD) in rats significantly. The histological changes observed in the liver correlated with the biochemical findings. However, these effects of TCDD on oxidative and histological changes were eliminated by Q and CH treatment. In conclusion, TCDD caused an adverse effect on rat's liver. When Q and CH were given together with TCDD, they prevented hepatotoxicty induced by TCDD. Thus, it is thought that Q and CH may be useful as a new category of anti-TCDD toxicity agent.
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Toxicology, University of Inonu, 44280 Malatya, Turkey. ociftci@inonu.edu.tr
authors.forename: Osman
authors.initials: O
authors.lastname: Ciftci
authors.forename: Nigar
authors.initials: N
authors.lastname: Vardi
authors.forename: Ilknur
authors.initials: I
authors.lastname: Ozdemir
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control*; D004147:Dioxins / Q000494:pharmacology; D004347:Drug Interactions; D004785:Environmental Pollutants / Q000633:toxicity; D005419:Flavonoids / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D004147:Dioxins; D004785:Environmental Pollutants; D005419:Flavonoids; D000072317:Polychlorinated Dibenzodioxins; C043561:chrysin; D011794:Quercetin; D005978:Glutathione