title: The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development.
abstract: Development in plants is controlled by abiotic environmental cues such as day length, light quality, temperature, drought, and salinity. These signals are sensed by a variety of systems and transmitted by different signal transduction pathways. Ultimately, these pathways are integrated to control expression of specific target genes, which encode proteins that regulate development and differentiation. The molecular mechanisms for such integration have remained elusive. We here show that a linear 130-amino-acids-long sequence in the Med25 subunit of the Arabidopsis thaliana Mediator is a common target for the drought response element binding protein 2A, zinc finger homeodomain 1, and Myb-like transcription factors which are involved in different stress response pathways. In addition, our results show that Med25 together with drought response element binding protein 2A also function in repression of PhyB-mediated light signaling and thus integrate signals from different regulatory pathways.
authors.affiliation: Department of Medical Biochemistry and Biophysics, Umeå Plant Science Center, Umeå University, SE-901 87 Umeå, Sweden.
authors.forename: Nils
authors.initials: N
authors.lastname: Elfving
authors.forename: Céline
authors.initials: C
authors.lastname: Davoine
authors.forename: Reyes
authors.initials: R
authors.lastname: Benlloch
authors.forename: Jeanette
authors.initials: J
authors.lastname: Blomberg
authors.forename: Kristoffer
authors.initials: K
authors.lastname: Brännström
authors.forename: Dörte
authors.initials: D
authors.lastname: Müller
authors.forename: Anders
authors.initials: A
authors.lastname: Nilsson
authors.forename: Mikael
authors.initials: M
authors.lastname: Ulfstedt
authors.forename: Hans
authors.initials: H
authors.lastname: Ronne
authors.forename: Gunnar
authors.initials: G
authors.lastname: Wingsle
authors.forename: Ove
authors.initials: O
authors.lastname: Nilsson
authors.forename: Stefan
authors.initials: S
authors.lastname: Björklund
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000254:growth & development / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000502:physiology*; D001665:Binding Sites; D004268:DNA-Binding Proteins; D004777:Environment; D018506:Gene Expression Regulation, Plant / Q000502:physiology*; D056892:Mediator Complex / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology*; D021122:Protein Subunits / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013312:Stress, Physiological / Q000235:genetics; D014157:Transcription Factors
chemical_list: D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; D056892:Mediator Complex; D009687:Nuclear Proteins; C475686:PFT1 protein, Arabidopsis; D021122:Protein Subunits; D014157:Transcription Factors