title: The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes.
abstract: OBJECTIVE
  We investigated the risk associated with HLA-B*39 alleles in the context of specific HLA-DR/DQ haplotypes.
  
  
  METHODS
  We studied a readily available dataset from the Type 1 Diabetes Genetics Consortium that consists of 2,300 affected sibling pair families genotyped for both HLA alleles and 2,837 single nucleotide polymorphisms across the major histocompatibility complex region.
  
  
  RESULTS
  The B*3906 allele significantly enhanced the risk of type 1 diabetes when present on specific HLA-DR/DQ haplotypes (DRB1 0801-DQB1 0402: p = 1.6 × 10(-6), OR 25.4; DRB1 0101-DQB1 0501: p = 4.9 × 10(-5), OR 10.3) but did not enhance the risk of DRB1 0401-DQB1 0302 haplotypes. In addition, the B 3901 allele enhanced risk on the DRB1 1601-DQB1 0502 haplotype (p = 3.7 × 10(-3), OR 7.2).
  
  
  CONCLUSIONS
  These associations indicate that the B 39 alleles significantly increase risk when present on specific HLA-DR/DQ haplotypes, and HLA-B typing in concert with specific HLA-DR/DQ genotypes should facilitate genetic prediction of type 1 diabetes, particularly in a research setting.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Box B140, Aurora, CO 80045-6511, USA.
authors.forename: E E
authors.initials: EE
authors.lastname: Baschal
authors.forename: P R
authors.initials: PR
authors.lastname: Baker
authors.forename: K R
authors.initials: KR
authors.lastname: Eyring
authors.forename: J C
authors.initials: JC
authors.lastname: Siebert
authors.forename: J M
authors.initials: JM
authors.lastname: Jasinski
authors.forename: G S
authors.initials: GS
authors.lastname: Eisenbarth
mesh_terms: D000483:Alleles; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans
chemical_list: D015235:HLA-B Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens