title: Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate.
abstract: Nanostructured lipid carrier (NLC)-loaded bifendate (DDB) was prepared by melt-emulsification method to improve drug payloads and liver targeting. The particle size of the prepared formulation analysed by photon correlation spectroscopy (PCS) was 217.4 nm with a narrow polydispersity index (PI) lower than 0.2, meanwhile the loading capacity increased from 4.3% to 15.7% in comparison with DDB-loaded SLN reported in previous study. The zeta potential value was -21.91 mV, and transmission electron microscopy studies revealed NLC of irregularly spherical shape. With respect to lipid polymorphism, a less ordered structure of NLC was confirmed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, tissue distribution of DDB-loaded NLC and DDB solution were carried out in Kunming strain mice. In tested organs, the distribution of DDB-loaded NLC to liver was higher than that of free drug. These results support the potential applications of NLC for the delivery of DDB.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan, Shandong Province, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Feng
authors.forename: Dandan
authors.initials: D
authors.lastname: Zheng
authors.forename: Dianrui
authors.initials: D
authors.lastname: Zhang
authors.forename: Cunxian
authors.initials: C
authors.lastname: Duan
authors.forename: Yancai
authors.initials: Y
authors.lastname: Wang
authors.forename: Lejiao
authors.initials: L
authors.lastname: Jia
authors.forename: Feihu
authors.initials: F
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.forename: Qun
authors.initials: Q
authors.lastname: Gao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D008055:Lipids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008099:Liver; D051379:Mice; D010316:Particle Size
chemical_list: D001713:Biphenyl Compounds; D008055:Lipids; C465548:bifendate