title: Levels and profiles of PCDD/Fs, PCBs in mothers' milk in Shenzhen of China: estimation of breast-fed infants' intakes.
abstract: Sixty breast milk samples were collected in Shenzhen, China from July to November in 2007. The samples were analyzed of the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs). The range of upper-bound for ∑TEQ-(PCDD/Fs+PCBs) in the samples was 4.10-35.3 pg TEQ g(-1) lipid (median: 10.6 pg TEQ g(-1) lipid; mean: 11.9 pg TEQ g(-1) lipid). The levels of the measured contaminants in the breast milk had significant correlations with the length of inhabitation period in Shenzhen (r=0.487, p<0.05 for PCDD/Fs, r=0.431, p<0.05 for PCBs and r=0.478, p<0.05 for ∑TEQ-(PCDD/Fs+PCBs)), and the consumption rate of fish (r=0.366, p<0.05 for PCDD/Fs, r=0.486, p<0.05 for PCBs and r=0.416, p<0.05 for ∑TEQ-(PCDD/Fs+PCBs)), respectively. Moreover, significant positive correlations were also detected between the participant's age (r=0.305, p<0.05 for ∑TEQ-PCBs and r=0.275, p<0.05 for ∑TEQ-(PCDD/Fs+PCBs)) and the body burdens of these contaminants respectively. It is estimated that the daily intake (EDI) of the sum of PCDD/Fs and DL-PCBs by the breast-fed infants was 5.60-161 pg TEQ kg(-1) bw per day (mean: 48.2 pg TEQ kg(-1) bw per day; median: 42.2 pg TEQ kg(-1) bw per day). The result showed that both the body burdens of PCDD/Fs and PCBs of the recruit population and the calculated EDI of the breast-fed infants were higher than those in the non-exposed areas in mainland China. This suggests that continuous surveillance on PCDD/Fs and PCBs levels in human milk is critical to more precisely evaluate the human health risk posed by the negative environmental impact in Shenzhen in the future.
authors.affiliation: Department of POPs Lab, Shenzhen Center for Disease Control and Prevention, No. 21, 1st Road Tianbei, Luohu District, Shenzhen, Guangdong 518020, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Deng
authors.forename: JianQing
authors.initials: J
authors.lastname: Zhang
authors.forename: Lishi
authors.initials: L
authors.lastname: Zhang
authors.forename: YouSheng
authors.initials: Y
authors.lastname: Jiang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Daokui
authors.initials: D
authors.lastname: Fang
authors.forename: Huiming
authors.initials: H
authors.lastname: Zhang
authors.forename: HaiYan
authors.initials: H
authors.lastname: Huang
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000378:metabolism*; D001822:Body Burden; D001942:Breast Feeding / Q000706:statistics & numerical data; D002681:China; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000378:metabolism*; D004787:Environmental Pollution / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008895:Milk, Human / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000378:metabolism*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000378:metabolism; D055815:Young Adult
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls; C020887:dibenzo(1,4)dioxin