title: Male urethral Pap smears and peniscopy examination and polymerase chain reaction human papillomavirus correlation.
abstract: The aims of this study were to determine HPV in a male population and its correlation with penile gross inspection and urethral pap smears. Fifty male volunteers were included in the study; all of them were sexual partners of women with evidence of HPV-related cervical diseases. Urethral Pap smear features and polymerase chain reaction (PCR; HPV detection) of urethral samples were correlated. Statistical analyses were conducted to identify variables associated with high and low-risk HPV types. Mean age of participants was 33.14 ± 1.52 (range, 23-50 years), and the mean age for those with high risk HPV was 32.12 ± 6.66 and 34.08 ± 6.58 for subjects with low-risk HPV (P = 0.820). Penile gross inspection revealed 19 (38%) cases with no lesions, papules in balanoprepusial furrol/sulcus in 23 (46%) cases, papilla in 23 (46%) cases, urethral lesions in 22 (44%) cases, penile body plaques in 22 (44%) cases, melanoses in 11 (22%) cases, sebaceous cysts on scrotum in 10 (20%) cases, and molting of the glands in 28 (56%) cases. Cytopathologic analysis revealed koilocytes in 24 (48%) cases. Dyskeratosis was observed in 24 (48%) cases. A bacterial background was found in 27 (54%) cases, and inflammatory cells were found in 27 (54%) cases. Twenty-six (52%) cases showed cytological features suggestive of Gardnerella Vaginalis. Twenty-four (48%) cases were high-risk HPV, and 26 (52%) were low-risk HPV (P = 0.037) as assessed by PCR-based detection. There was a statistically significant difference between koilocytes and bacterial background with high-risk human papillomavirus (P = 0.001). Abnormal colposcopy examination detected lesions were sampled for cytology by Pap smears.
authors.affiliation: Laboratory of Experimental Neuropathology, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico. tenasuck@yahoo.com.mx
authors.forename: Martha Lilia
authors.initials: ML
authors.lastname: Tena-Suck
authors.forename: América
authors.initials: A
authors.lastname: Alarcón-Herrera
authors.forename: Andrés
authors.initials: A
authors.lastname: Tirado-Sánchez
authors.forename: Frank
authors.initials: F
authors.lastname: Rösl
authors.forename: Horacio
authors.initials: H
authors.lastname: Astudillo-de la Vega
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology; D001706:Biopsy / Q000379:methods*; D006194:Gardnerella vaginalis / Q000302:isolation & purification / Q000472:pathogenicity; D005837:Genitalia, Male / Q000382:microbiology / Q000473:pathology* / Q000821:virology; D006801:Humans; D008297:Male; D008548:Melanosis / Q000382:microbiology / Q000473:pathology / Q000821:virology; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000473:pathology* / Q000635:transmission / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods*; D015995:Prevalence; D012307:Risk Factors; D014521:Urethra / Q000382:microbiology / Q000473:pathology* / Q000821:virology; D055815:Young Adult