title: Non-invasive measurement of local tissue perfusion and its correlation with hemodynamic indices during the early postnatal period in term neonates.
abstract: OBJECTIVE
  Monitoring the changes in buccal tissue oxygen saturation (StO(2)) may aid in early diagnosis of circulatory compromise. Our objective was to define the normal value of buccal StO(2) and its correlation to the middle cerebral artery (MCA) flow indices and cardiac output in healthy term infants during the first 48 h after birth.
  
  
  METHODS
  In this prospective study, we assessed buccal StO(2) by visible light spectroscopy and assessed the left ventricular output (LVO) and MCA flow indices by ultrasound on postnatal days 1 and 2. We enrolled 20 term neonates. The Wilcoxon-matched pairs signed-rank test and Pearson correlation were used to analyze the data.
  
  
  RESULTS
  Median (range) buccal StO(2) readings were 68% (62 to 72) on day 1 and 66% (61 to 69) on day 2 (P=0.03). A weak but significant positive correlation was found between buccal StO(2) and LVO (r=0.37, P=0.023). There was no correlation between buccal StO(2) and MCA mean velocity or pulsatility index.
  
  
  CONCLUSIONS
  Under a physiological state, buccal StO(2) in resting healthy neonates is 61 to 72%, regardless of variability in systemic and cerebral blood flow. Because of its ease of use and non-invasive nature, the use of visible light spectroscopy in conditions with circulatory compromise needs to be further investigated.
authors.affiliation: Section of Neonatal-Perinatal Medicine, Department of Pediatrics, The Children's Hospital, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. snoori@chla.usc.edu
authors.forename: S
authors.initials: S
authors.lastname: Noori
authors.forename: B
authors.initials: B
authors.lastname: Drabu
authors.forename: M
authors.initials: M
authors.lastname: McCoy
authors.forename: K
authors.initials: K
authors.lastname: Sekar
mesh_terms: D001783:Blood Flow Velocity; D002302:Cardiac Output; D002610:Cheek / Q000098:blood supply; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000502:physiology*; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000032:analysis; D012016:Reference Values; D013057:Spectrum Analysis / Q000295:instrumentation*; D014463:Ultrasonography; D016277:Ventricular Function, Left
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen