title: Extranodal NK/T-cell lymphoma: toward the identification of clinical molecular targets.
abstract: Extranodal natural killer (NK)/T-cell lymphoma of nasal type (NKTCL) is a malignant disorder of cytotoxic lymphocytes of NK or more rarely T cells associated with clonal Epstein-Barr virus infection. Extranodal NKTCL is rare in Western countries, but in Asia and Central and South America it can account for up to 10% of non-Hodgkin's lymphomas. It is an aggressive neoplasm with very poor prognosis. Although the pathogenesis of extranodal NKTCL remains poorly understood, some insights have been gained in the recent years, especially from genome-wide studies. Based on our own experience and knowledge of the literature, we here review some of the genomic and functional pathway alterations observed in NKTCL that could provide a rationale for the development of innovative therapeutic strategies.
authors.affiliation: INSERM U976, Paris, France. christian.schmitt@inserm.fr
authors.forename: Christian
authors.initials: C
authors.lastname: Schmitt
authors.forename: Nouhoum
authors.initials: N
authors.lastname: Sako
authors.forename: Martine
authors.initials: M
authors.lastname: Bagot
authors.forename: Yenlin
authors.initials: Y
authors.lastname: Huang
authors.forename: Philippe
authors.initials: P
authors.lastname: Gaulard
authors.forename: Armand
authors.initials: A
authors.lastname: Bensussan
mesh_terms: D003602:Cytotoxicity, Immunologic; D020031:Epstein-Barr Virus Infections / Q000150:complications; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000821:virology; D055611:Natural Killer T-Cells / Q000276:immunology / Q000473:pathology; D015398:Signal Transduction / Q000276:immunology; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D014764:Viral Proteins