title: Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents.
abstract: Parkia platycephala Benth. (Leguminosae--Mimosoideae), popularly known as "visgueira", fava bean tree or "fava-de-bolota", is widely found in the Northern and Northeastern regions of Brazil. Its pods are used as cattle food supplement in the drought period. Compounds with a gastroprotective activity were obtained from the genus Parkia. Therefore, this study aimed at investigating the gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves (Pp-EtOH), as well as evaluating its possible mechanisms of action in experimental ulcer induction models. Lesions were induced by absolute ethanol, ethanol-HCl, ischemia-reperfusion and indomethacin in rodents. Pp-EtOH showed a protective effect in the lesion models (66, 48 and 52%, respectively), but it was not able to protect gastric mucosa against indomethacin-induced lesions. Results show a possible participation of the NO-synthase pathway in the gastroprotection and an antioxidant activity, by the increase of the catalase activity. The participation of prostaglandins and potassium channels sensitive to ATP in the gastroprotective effect of Pp-EtOH seems less likely to occur. More comprehensive studies, therefore, should be carried out to elucidate the antiulcerative effects of this promising natural product against this gastrointestinal disorder.
authors.affiliation: Medicinal Plants Research Center, Federal University of Piauí, Minister Petrônio Portela Campus, Teresina, PI, Brazil.
authors.forename: Hélio B
authors.initials: HB
authors.lastname: Fernandes
authors.forename: Francilene V
authors.initials: FV
authors.lastname: Silva
authors.forename: Flávia Franceli B
authors.initials: FF
authors.lastname: Passos
authors.forename: Roosevelt D S
authors.initials: RD
authors.lastname: Bezerra
authors.forename: Mariana H
authors.initials: MH
authors.lastname: Chaves
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Oliveira
authors.forename: Rita C Meneses
authors.initials: RC
authors.lastname: Oliveira
mesh_terms: D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects; D007887:Fabaceae / Q000737:chemistry* / Q000145:classification; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol; D007213:Indomethacin