title: Filtek™ Silorane and Filtek™ Supreme XT resins: tissue reaction after subcutaneous implantation in isogenic mice.
abstract: The aim of this study was to evaluate the tissue compatibility of a silorane-based resin system (Filtek™ Silorane) and a methacrylate-based nanoparticle resin (Filtek™ Supreme XT) after implantation in the subcutaneous connective tissue of isogenic mice. One hundred and thirty five male isogenic BALB/c mice were randomly assigned to 12 experimental and 3 control groups, according to the implanted material and the experimental period of 7, 21 and 63 days. At the end of each period, the animals were killed and the tubes with the surrounding tissues were removed and processed for microscopic analysis. Samples were subjected to a descriptive and a semi-quantitative analyses using a 4-point scoring system (0-3) to evaluate the collagen fiber formation and inflammatory infiltrate. Data were statistically analyzed using the Kruskal Wallis test (α=0.05). The results showed that there was no significant difference between the experimental and control groups considering the three evaluation periods (p>0.05). The silorane-based and the methacrylate-based nanoparticle resins presented similar tissue response to that of the empty tube (control group) after subcutaneous implantation in isogenic mice.
authors.affiliation: La Societad Catalana d’odontoestomatologia de l’Acadèmia de Ciències Mèdiques I de la Salut de Catalunya I de Balears, Barcelona, Spain.
authors.forename: Esther Ruiz De
authors.initials: ER
authors.lastname: Castañeda
authors.forename: Léa A B
authors.initials: LA
authors.lastname: Silva
authors.forename: Patrícia
authors.initials: P
authors.lastname: Gaton-Hernández
authors.forename: Alberto
authors.initials: A
authors.lastname: Consolaro
authors.forename: Encarnación Gonzalez
authors.initials: EG
authors.lastname: Rodriguez
authors.forename: Raquel A B
authors.initials: RA
authors.lastname: Silva
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Queiroz
authors.forename: Paulo
authors.initials: P
authors.lastname: Nelson-Filho
mesh_terms: D000818:Animals; D003188:Composite Resins / Q000737:chemistry / Q000633:toxicity*; D024022:Fibrillar Collagens / Q000096:biosynthesis; D005549:Foreign-Body Reaction; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing; D008689:Methacrylates / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D062047:Silorane Resins; D012833:Siloxanes / Q000633:toxicity*; D040521:Subcutaneous Tissue / Q000187:drug effects*
chemical_list: D003188:Composite Resins; D024022:Fibrillar Collagens; C474035:Filtek Supreme; D008689:Methacrylates; D062047:Silorane Resins; D012833:Siloxanes; C555513:silorane composite resin