title: Photoswitchable nanoprobes offer unlimited brightness in frequency-domain imaging.
abstract: A single probe has limited brightness in time-domain imaging and such limitation frequently renders individual molecules undetectable in the presence of interference or complex cellular structures. However, a single photoswitchable probe produces a signal, which can be separated from interference or noise using photoswitching-enabled Fourier transformation (PFT). As a result, the light-modulated probes can be made super bright in the frequency domain simply by acquiring more cycles in the time domain.
authors.affiliation: Department of Chemistry and Center for Materials Research, Washington State University, Pullman, Washington 99164, USA. dequan@wsu.edu
authors.forename: Alexander D Q
authors.initials: AD
authors.lastname: Li
authors.forename: Chuanlang
authors.initials: C
authors.lastname: Zhan
authors.forename: Dehong
authors.initials: D
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Wan
authors.forename: Jiannian
authors.initials: J
authors.lastname: Yao
mesh_terms: D005583:Fourier Analysis; D015335:Molecular Probes; D036103:Nanotechnology; D010777:Photochemistry
chemical_list: D015335:Molecular Probes