title: Prognostic factors in patients with malignant salivary gland neoplasms in a Brazilian population.
abstract: Due to the difficulty of follow-up for long periods, information about the survival rates of malignant salivary gland tumors is deficient in the global scientific literature. This study was aimed at investigating the epidemiological profile and prognostic factors that might affect survival in patients with primary malignant salivary gland tumors in Brazil. Patients were investigated regarding histopathological subtypes, age, gender, anatomic localization, smoking and alcohol intake, tumor size, clinical stage, histological grade, recurrence, metastasis, and treatment on clinicopathological outcomes. Survival curves were generated using the Kaplan-Meier method, and both univariate and multivariate analyses were performed using the log rank test and Cox regression, respectively. A total of 63 cases were analyzed, females being slightly predominant (50.8%), with ages ranging from 13 to 87 years. The most common diagnosis was adenoid cystic carcinoma and the most affected anatomical location was the parotid. Tumors were predominantly classified as stage I and high-grade at the diagnosis. The 5- and 10-year overall survival rates were 84.6% and 74.7%, respectively. Disease-free survival (DFS) rates were 71.6% (5 years) and 56.6% (10 years). Univariate analysis showed significant effects of tumor size and clinical stage on the DFS (P<0.0001 for both), and Cox regression analysis confirmed clinical stage as an independent prognostic factor (P = 0.035). Our results highlight the relevance of clinical stage as an independent prognostic parameter for malignant salivary gland tumors.
authors.affiliation: Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Lucinei Roberto
authors.initials: LR
authors.lastname: Oliveira
authors.forename: Danilo Figueiredo
authors.initials: DF
authors.lastname: Soave
authors.forename: Joao Paulo
authors.initials: JP
authors.lastname: Oliveira-Costa
authors.forename: Veronica Assalin
authors.initials: VA
authors.lastname: Zorgetto
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ribeiro-Silva
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D003528:Carcinoma, Adenoid Cystic / Q000556:secondary* / Q000628:therapy; D018277:Carcinoma, Mucoepidermoid / Q000556:secondary* / Q000628:therapy; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate; D055815:Young Adult