title: Reanalysis of a randomized trial of 3 techniques of anterior colporrhaphy using clinically relevant definitions of success.
abstract: OBJECTIVE
  The purpose of this study was to reanalyze the results of a previously published trial that compared 3 methods of anterior colporrhaphy according to the clinically relevant definitions of success.
  
  
  METHODS
  A secondary analysis of a trial of 114 subjects who underwent surgery for anterior pelvic organ prolapse who were assigned randomly to standard anterior colporrhaphy, ultralateral colporrhaphy, or anterior colporrhaphy plus polyglactin 910 mesh from 1996-1999. For the current analysis, success was defined as (1) no prolapse beyond the hymen, (2) the absence of prolapse symptoms (visual analog scale ≤ 2), and (3) the absence of retreatment.
  
  
  RESULTS
  Eighty-eight percent of the women met our definition of success at 1 year. One subject (1%) underwent surgery for recurrence 29 months after surgery. No differences among the 3 groups were noted for any outcomes.
  
  
  CONCLUSIONS
  Reanalysis of a trial of 3 methods of anterior colporrhaphy revealed considerably better success with the use of clinically relevant outcome criteria compared with strict anatomic criteria.
authors.affiliation: Obstetrics, Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Chmielewski
authors.forename: Mark D
authors.initials: MD
authors.lastname: Walters
authors.forename: Anne M
authors.initials: AM
authors.lastname: Weber
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Barber
mesh_terms: D000368:Aged; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D011098:Polyglactin 910 / Q000627:therapeutic use; D012008:Recurrence; D016896:Treatment Outcome; D014621:Vagina / Q000601:surgery*
chemical_list: D011098:Polyglactin 910