title: Distribution of serum prostate-specific antigen in Chinese healthy men: a population-based study.
abstract: BACKGROUND
  The morbidity and mortality of prostate cancer have been increasing rapidly in recent China. There were few studies investigating prostate-specific antigen (PSA) values ranges in the healthy Chinese population. We performed this study to determine the distribution of serum PSA in a large healthy Chinese population.
  
  
  METHODS
  From January 2001 to May 2008, 11 150 healthy Chinese men aged 30 - 79 years came to our hospital for routine health check-up. All subjects without a previous diagnosis of prostate cancer, a history of prostate surgery, or urogenital tract infection were proposed to undergo systematic serum PSA measurement and digital rectal examination (DRE). Men with normal DRE and PSA ≤ 4.0 ng/ml and those PSA > 4.0 ng/ml or abnormal DRE but without adverse findings on prostate biopsy were included (n = 9358). Age and serum PSA concentration were recorded and correlated through Logistic regression analysis.
  
  
  RESULTS
  The 95th percentile serum PSA concentration was 1.89 ng/ml for men aged 30 to 39 years, 2.19 ng/ml for men aged 40 to 49 years, 2.88 ng/ml for men aged 50 to 59 years, 4.42 ng/ml for men aged 60 to 69 years, and 6.52 ng/ml for men aged 70 to 79 years. The serum PSA concentration correlated with age (P < 0.0001) with an annual increase of 0.97% for men in 40 years, 1.58% for men in 50 years, 3.04% for men in 60 years, and 3.99% for men in 70 years.
  
  
  CONCLUSIONS
  The serum PSA level correlates directly with age in Chinese men older than 40 years, not in Chinese men younger than 40 years old. Chinese men have lower PSA level compared with white men above 60 years of age, not in those under 60 years of age.
authors.affiliation: Department of Urology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Yuan
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Dong
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Lin
authors.forename: Xin-hong
authors.initials: XH
authors.lastname: Song
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Niu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.forename: Shuai
authors.initials: S
authors.lastname: Liu
authors.forename: Zhi-jian
authors.initials: ZJ
authors.lastname: Sun
authors.forename: Jia-ju
authors.initials: JJ
authors.lastname: Lü
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology
chemical_list: D017430:Prostate-Specific Antigen