title: 3D simulation of internal tablet strength during tableting.
abstract: This study presents a new approach to model powder compression during tableting. The purpose of this study is to introduce a new discrete element simulation model for particle-particle bond formation during tablet compression. This model served as the basis for calculating tablet strength distribution during a compression cycle. Simulated results were compared with real tablets compressed from microcrystalline cellulose/theophylline pellets with various compression forces. Simulated and experimental compression forces increased similarly. Tablet-breaking forces increased with the calculated strengths obtained from the simulations. The calculated bond strength distribution inside the tablets showed features similar to those of the density and pressure distributions in the literature. However, the bond strength distributions at the center of the tablets varied considerably between individual tablets.
authors.affiliation: Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Finland. simo.siiria@helsinki.fi
authors.forename: Simo Matti
authors.initials: SM
authors.lastname: Siiriä
authors.forename: Osmo
authors.initials: O
authors.lastname: Antikainen
authors.forename: Jyrki
authors.initials: J
authors.lastname: Heinämäki
authors.forename: Jouko
authors.initials: J
authors.lastname: Yliruusi
mesh_terms: D002482:Cellulose / Q000737:chemistry / Q000592:standards; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000592:standards; D019245:Compressive Strength; D003198:Computer Simulation / Q000592:standards; D008958:Models, Molecular; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000592:standards; D013607:Tablets / Q000592:standards; D013806:Theophylline / Q000737:chemistry / Q000592:standards
chemical_list: D004364:Pharmaceutical Preparations; D013607:Tablets; D002482:Cellulose; D013806:Theophylline; C109691:microcrystalline cellulose