title: No effect of oral contraceptives on the metabolism of levetiracetam.
abstract: The effect on clearance of levetiracetam (LEV) was estimated in women with epilepsy of childbearing potential using oral contraceptives (OCs). The estimated clearance (plasma concentration/daily dose) was 39 nmol/L/mg (range 14-88 nmol/L/mg) among women who did not use OC (n=30) and 38 nmol/L/mg (range 18-103 nmol/L/mg) among OC users (n=23) (p=0.8). In conclusion, combing LEV and OCs seems safe from a pharmacokinetic perspective.
authors.affiliation: The Epilepsy Clinic, Department of Neurology, Rigshospitalet University State Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. anne.sabers@rh.regionh.dk
authors.forename: Anne
authors.initials: A
authors.lastname: Sabers
authors.forename: Jacob
authors.initials: J
authors.lastname: Christensen
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000097:blood* / Q000627:therapeutic use; D003276:Contraceptives, Oral / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008875:Middle Aged; D010889:Piracetam / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D003276:Contraceptives, Oral; D000077287:Levetiracetam; D010889:Piracetam