title: Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration.
abstract: Neutron activation of Sm-152 offers a method of radiolabeling for the in vivo study of oral dose formulations by gamma scintigraphy. Reproducibility measurements are needed to ensure the robustness of clinical studies. 204 enteric-coated guaifenesin core tablets (10mg of Sm(2)O(3)) were irradiated by thermal neutrons to achieve 1 MBq at 48 h. Administered activities were 0.86±0.03 MBq. Good reproducibility (CV=3.5%) was observed over 24 weeks ensuring that volunteer doses were within the dose reference level of 0.8 mSv.
authors.affiliation: Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: C H
authors.initials: CH
authors.lastname: Yeong
authors.forename: P E
authors.initials: PE
authors.lastname: Blackshaw
authors.forename: K H
authors.initials: KH
authors.lastname: Ng
authors.forename: B J J
authors.initials: BJ
authors.lastname: Abdullah
authors.forename: M
authors.initials: M
authors.lastname: Blaauw
authors.forename: R J
authors.initials: RJ
authors.lastname: Dansereau
authors.forename: A C
authors.initials: AC
authors.lastname: Perkins
mesh_terms: D000284:Administration, Oral; D006140:Guaifenesin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D007553:Isotope Labeling; D009501:Neutron Activation Analysis; D011868:Radioisotopes; D015203:Reproducibility of Results; D012493:Samarium
chemical_list: D011868:Radioisotopes; D012493:Samarium; D006140:Guaifenesin