title: Inhibitory activity of Plantago major L. on angiotensin I-converting enzyme.
abstract: Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Phan
authors.initials: P
authors.lastname: Van Kiem
authors.forename: Chau
authors.initials: C
authors.lastname: Van Minh
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Cuong
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: Tung
authors.forename: Vu Kim
authors.initials: VK
authors.lastname: Thu
authors.forename: Trinh Nam
authors.initials: TN
authors.lastname: Trung
authors.forename: Hoang Le Tuan
authors.initials: Hle T
authors.lastname: Anh
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Jo
authors.forename: Hae-Dong
authors.initials: HD
authors.lastname: Jang
authors.forename: Young-In
authors.initials: YI
authors.lastname: Kwon
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008168:Lung / Q000201:enzymology; D015394:Molecular Structure; D007703:Peptidyl-Dipeptidase A / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010943:Plantago / Q000737:chemistry*; D011817:Rabbits
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007703:Peptidyl-Dipeptidase A