title: Effects of epidermal growth factor and mitogenic blockers on rat colonic tumour growth in vivo.
abstract: A protocol for tumour cell inoculation (Per192NR and Per237 rat colon cancer cells) and implantation of mini-osmotic pumps in inbred rats was established. Surgical procedures and tumour growth did not affect red and white blood cell counts. Per237 did not grow in these rats while Per192NR formed poorly differentiated carcinomas which were not affected by EGF intraperitoneal (IP) or intravenous (IV), oleic acid (IP) or verapamil (IP or oral) administration. Haematological parameters and rat growth rates were not affected by EGF (IP and IV), verapamil (IP) and oleic acid (IP) treatment. This protocol provides a method for studying the effect of various cancer drugs in vivo.
authors.affiliation: UNIV WESTERN AUSTRALIA,QUEEN ELIZABETH II MED CTR,DEPT SURG,NEDLANDS,WA 6009,AUSTRALIA.
authors.forename: D
authors.initials: D
authors.lastname: Lopez
authors.forename: A
authors.initials: A
authors.lastname: House