title: NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95.
abstract: We synthesized small organic molecules designed as PDZ ligands. These indole-based compounds were evaluated for their interaction with the PDZ1 domain of the post-synaptic density 95 (PSD-95) protein. Three molecules were found to interact with the targeted PDZ protein by NMR. One of them showed chemical shift perturbations closely related to the natural ligands.
authors.affiliation: Clermont Université, UBP, EA 987, LCHG, BP 10448, F-63000 Clermont-Ferrand, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vogrig
authors.forename: Benjamin
authors.initials: B
authors.lastname: Boucherle
authors.forename: Hemantkumar
authors.initials: H
authors.lastname: Deokar
authors.forename: Isabelle
authors.initials: I
authors.lastname: Thomas
authors.forename: Isabelle
authors.initials: I
authors.lastname: Ripoche
authors.forename: Lu-Yun
authors.initials: LY
authors.lastname: Lian
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ducki
mesh_terms: D000818:Animals; D000076122:Disks Large Homolog 4 Protein; D051528:Guanylate Kinases / Q000737:chemistry*; D006860:Hydrogen Bonding; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008565:Membrane Proteins / Q000737:chemistry*; D051379:Mice; D008958:Models, Molecular; D017434:Protein Structure, Tertiary
chemical_list: D000076122:Disks Large Homolog 4 Protein; C501447:Dlg4 protein, mouse; D007211:Indoles; D008565:Membrane Proteins; C030374:indole; D051528:Guanylate Kinases