title: Atrioventricular node ablation and pacemaker implantation for recurrent syncope in a patient with postural tachycardia syndrome (POTS).
abstract: Ablate and pace for POTS. A 42-year-old woman with postural tachycardia syndrome (POTS) was admitted to our hospital with severe palpitations, light-headedness, and syncope. Several drugs had been administered previously, but all had been discontinued due to intolerable adverse effects or limited efficacy. One of the drugs, the I(f) current inhibitor ivabradine, effectively slowed the patient's heart rate and relieved the symptoms, but was discontinued due to allergy. After unsuccessful sinus node ablation, atrioventricular node ablation and dual chamber pacemaker implantation was performed, which dramatically improved her symptoms and eliminated syncope. Atrioventricular node ablation could modify the cardiac autonomic balance and thereby suppressed the excessive orthostatic sympathetic activity.
authors.affiliation: Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Toyama, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakatani
authors.forename: Koichi
authors.initials: K
authors.lastname: Mizumaki
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Nishida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inoue
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001283:Atrioventricular Node / Q000503:physiopathology / Q000601:surgery*; D002304:Cardiac Pacing, Artificial; D017115:Catheter Ablation; D004351:Drug Resistance; D015716:Electrocardiography, Ambulatory; D004867:Equipment Design; D005260:Female; D006339:Heart Rate; D006801:Humans; D010138:Pacemaker, Artificial; D054972:Postural Orthostatic Tachycardia Syndrome / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D012008:Recurrence; D013575:Syncope / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D018667:Tilt-Table Test; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents