title: The treatment of Dupuytren disease.
abstract: The treatment of progressive Dupuytren contractures has historically been and continues to be largely surgical. Although a number of surgical interventions do exist, limited palmar fasciectomy continues to be the most common and widely accepted treatment option. Until recently, nonsurgical options were limited and clinically ineffective. However, the commercial availability and recent approval of collagenase clostridium histolyticum now provides practitioners with a nonsurgical approach to this disease. This article presents a comprehensive review of the surgical and nonsurgical treatments of Dupuytren disease, with a focus on collagenase.
authors.affiliation: Newport Orthopedic Institute, Newport Beach, CA 92660, USA. shaunak1978@yahoo.com
authors.forename: Shaunak S
authors.initials: SS
authors.lastname: Desai
authors.forename: Vincent R
authors.initials: VR
authors.lastname: Hentz
mesh_terms: D047009:Hathewaya histolytica / Q000201:enzymology*; D004387:Dupuytren Contracture / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D000071938:Fasciotomy; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D003012:Microbial Collagenase / Q000627:therapeutic use*; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D019637:Orthopedic Procedures / Q000379:methods; D011379:Prognosis; D020127:Recovery of Function; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D003012:Microbial Collagenase