title: Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation.
abstract: Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl(4)) administration. Results showed that radon inhalation alleviates CCl(4)-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.
authors.affiliation: Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kataoka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sakoda
authors.forename: Masaaki
authors.initials: M
authors.lastname: Yoshimoto
authors.forename: Shinya
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Teruaki
authors.initials: T
authors.lastname: Toyota
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamato
authors.forename: Yuu
authors.initials: Y
authors.lastname: Ishimori
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawabe
authors.forename: Katsumi
authors.initials: K
authors.lastname: Hanamoto
authors.forename: Takehito
authors.initials: T
authors.lastname: Taguchi
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Yamaoka
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D008099:Liver / Q000187:drug effects / Q000528:radiation effects*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress; D011886:Radon / Q000008:administration & dosage*; D015427:Reperfusion Injury / Q000139:chemically induced / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D014964:X-Ray Therapy
chemical_list: D000975:Antioxidants; D013482:Superoxide Dismutase; D011886:Radon