title: Synthesis and antitumor activity of novel podophyllotoxin derivatives against multidrug-resistant cancer cells.
abstract: Seven novel 4β-N-substituted podophyllotoxin derivatives with indole rings were prepared and evaluated for cytotoxicity against human cancer cell lines HeLa, KB, KBV, K562, and K562/AO2. Most of them demonstrated improved antitumor activity and weak multidrug resistance compared to the drugs currently available.
authors.affiliation: Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, China. guoye@tust.edu.cn
authors.forename: Yong-En
authors.initials: YE
authors.lastname: Guo
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Song
authors.initials: S
authors.lastname: Zuo
authors.forename: Dai-Lin
authors.initials: DL
authors.lastname: Liu
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Lu
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Lv
authors.forename: Shao-Peng
authors.initials: SP
authors.lastname: Wen
authors.forename: Tong-Cun
authors.initials: TC
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D007624:KB Cells; D015394:Molecular Structure; D011034:Podophyllotoxin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011034:Podophyllotoxin