title: Vitreous inflammatory factors in macular edema with central retinal vein occlusion.
abstract: OBJECTIVE
  To investigate the correlation of soluble intercellular adhesion molecule 1 (sICAM-1) and vascular endothelial growth factor (VEGF) with macular edema in patients with central retinal vein occlusion (CRVO).
  
  
  METHODS
  Twenty-nine patients who had CRVO with macular edema and 16 patients with non-ischemic ocular diseases (control group) participated. Retinal ischemia was evaluated by measuring the area of capillary non-perfusion with fluorescein angiography and the public domain Scion Image program. Macular edema was examined by optical coherence tomography. Vitreous samples were obtained during pars plana vitrectomy. VEGF and sICAM-1 levels in vitreous fluid and plasma were determined by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The median vitreous levels of VEGF and sICAM-1 were significantly higher in the CRVO patients than in the control group [366 vs. 15.6 pg/ml (P < 0.001) and 20.5 vs. 5.0 ng/ml (P < 0.001), respectively]. Vitreous levels of both VEGF and sICAM-1 were also significantly higher in the CRVO patients who had retinal ischemia than in those without ischemia (P < 0.001 and P = 0.011, respectively). Vitreous levels of VEGF and sICAM-1 were also significantly correlated with the severity of macular edema (P = 0.004 and P = 0.012, respectively).
  
  
  CONCLUSIONS
  VEGF and sICAM-1 may both increase vascular permeability in CRVO patients with macular edema, with sICAM-1 acting together with and/or via VEGF.
authors.affiliation: Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96 Owada-shinden, Yachiyo, Chiba, 276-8524, Japan. nomahide@tymc.twmu.ac.jp.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Noma
authors.affiliation: Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96 Owada-shinden, Yachiyo, Chiba, 276-8524, Japan.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Funatsu
authors.affiliation: Department of Ophthalmology, Yodogawa Christian Hospital, Osaka, Japan.
authors.forename: Seiyo
authors.initials: S
authors.lastname: Harino
authors.affiliation: Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mimura
authors.affiliation: Department of Ophthalmology, Eguchi Eye Hospital, Hakodate, Japan.
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Eguchi
authors.affiliation: Department of Ophthalmology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Sadao
authors.initials: S
authors.lastname: Hori
mesh_terms: D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D017075:Laser Coagulation; D008269:Macular Edema / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism* / Q000601:surgery; D008297:Male; D012170:Retinal Vein Occlusion / Q000150:complications / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014792:Visual Acuity; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D018799:Intercellular Adhesion Molecule-1