title: T2 mapping of articular cartilage in knee osteoarthritis using a magnetic resonance staging.
abstract: OBJECTIVE
  To evaluate T2 mapping of articular cartilage in knee osteoarthritis (OA).
  
  
  METHODS
  Totally 38 healthy subjects (group H) and 53 OA patients received scoring with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)and underwent T2 mapping of tibiofemoral articular cartilages. The T2 values in 10 subregions of the cartilages were measured. Patients in the OA group were further divided into OA1 group and OA2 group using the modified Magnetic Resonance Recht Grading System. In OA group, the fat-suppressed three-dimensional fast spoiled gradient echo MRI was performed to obtain the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). The differences of T2 values among group H, group OA1, and group OA2 were compared. The correlation between T2 value and WORMS/WOMAC scores was analyzed. The intra- and inter-observer reproducibility of measurement was calculated.
  
  
  RESULTS
  The T2 values in all the subregions ranged 43.9-53.6ms in group H, 41.1-55.0 ms in group OA1, and 45.6-56.1ms in group OA2. T2 values in group OA2 were significantly higher in central medial femoral subregion, central medial, and lateral tibial subregions compared with group H, also significantly higher in central medial femoral subregion, anterior and central medial tibial subregions compared with group OA1 (P<0.05). T2 values were significantly correlated with WORMS scores (R=0.307-0.811, P<0.01) except in posterior lateral femoral subregion, but not with WOMAC scores. The correlation coefficients for intra- and inter-observer measurement showed good reproducibility (R>0.740, P<0.05) except in anterior lateral tibial subregion for inter-observer of measurement.
  
  
  CONCLUSIONS
  T2 mapping can differentiate the OA severity of knee cartilage using a magnetic resonance staging, and therefore can be a sensitive technique for monitoring the severity of OA.
authors.affiliation: Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Na
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yan
authors.forename: Sheng
authors.initials: S
authors.lastname: Min
authors.forename: Wu
authors.initials: W
authors.lastname: Zhi-hong
authors.forename: Jin
authors.initials: J
authors.lastname: Jin
authors.forename: Bao
authors.initials: B
authors.lastname: Fei
authors.forename: Meng
authors.initials: M
authors.lastname: Wei
authors.forename: Xu
authors.initials: X
authors.lastname: Jin
authors.forename: Jiang
authors.initials: J
authors.lastname: Bo
authors.forename: Liu
authors.initials: L
authors.lastname: Dong
authors.forename: Jin
authors.initials: J
authors.lastname: Zheng-yu
mesh_terms: D000328:Adult; D002358:Cartilage, Articular; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis*