title: Secondary childhood acute myeloid leukemia with complex karyotypic anomalies including monosomy 7, monosomy 5 and translocation (1;10) after 131I-metaiodobenzylguanidine therapy for relapsed neuroblastoma.
abstract: The prognosis for relapsing or refractory neuroblastoma (NB) remains dismal, with a five-year disease-free survival of < 20%, and no effective salvage treatment has been identified so far. 131I-metaiodobenzylguanidine (131I-MIBG) has come to play an essential role in the imaging and therapy of NB over the past 30 years. The role of 131I-MIBG in the treatment of NB is continually expanding. 131I-MIBG treatment together with cumulative doses of other alkylating agents has potential serious late side effects such as myelodysplasia and leukemia, although rare. We describe a secondary acute myeloid leukemia case with complex karyotypic anomalies that included monosomy 5, monosomy 7 and translocation (1;10) in a child with relapsed NB who received therapeutic 131I-MIBG.
authors.affiliation: Department of Pediatric Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
authors.forename: Sonay
authors.initials: S
authors.lastname: Incesoy-Ozdemir
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Bozkurt
authors.forename: Nazmiye
authors.initials: N
authors.lastname: Yüksek
authors.forename: Ayşe Ceyda
authors.initials: AC
authors.lastname: Oren
authors.forename: Gürses
authors.initials: G
authors.lastname: Sahin
authors.forename: Süreyya
authors.initials: S
authors.lastname: Bozkurt
authors.forename: Ulya
authors.initials: U
authors.lastname: Ertem
mesh_terms: D019797:3-Iodobenzylguanidine / Q000627:therapeutic use*; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology* / Q000235:genetics; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D009006:Monosomy; D009447:Neuroblastoma / Q000188:drug therapy* / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D007457:Iodine Radioisotopes; D019797:3-Iodobenzylguanidine