title: An acetylenic alkaloid from the calcareous sponge Leucetta sp.
abstract: A new acetylenic alkaloid was isolated from the sponge Leucetta sp. The structure was established by analyzing spectroscopic data. The alkaloid showed cytotoxicity IC₅₀ 2.5 μg/mL against NBT-T2 cells.
authors.affiliation: Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
authors.forename: Idam
authors.initials: I
authors.lastname: Hermawan
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: de Voogd
authors.forename: Junichi
authors.initials: J
authors.lastname: Tanaka
mesh_terms: D000114:Acetylene / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000470:Alkaloids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D020128:Inhibitory Concentration 50; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D013057:Spectrum Analysis
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D000114:Acetylene