title: IL-2 receptor expression and ki-67 flow cytometric analysis in B-chronic lymphocytic-leukemia.
abstract: Chronic lymphocytic leukemia (CLL) is typically an indolent lympho-proliferative disorder. Its clinical course is notable for marked heterogeneity, but in a subset of patients, the disease pursues a relatively rapid clinical course. To identify patients that may have aggressive disease, the growth fraction as determined by Ki-67 proliferation marker, DNA and RNA content, and IL-2 receptor expression were determined in 46 patients with CLL by flow cytometry. Our results indicate a significant statistical correlation between Ki-67 positivity and IL-2 expression in B-CLL cells. No correlation between the proliferative activity or RNA content and IL-2 expression was found. Our data indicate that measurement of both IL-2 receptor and Ki-67 expression in B-CLL can identify a subset of patients with a high risk of rapid clinical progression.
authors.affiliation: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT PATHOL,DIV PATHOL,HOUSTON,TX 77030. UNIV TEXAS,MD ANDERSON CANC CTR,DEPT LAB MED,HOUSTON,TX 77030. UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEMATOL,HOUSTON,TX 77030.
authors.forename: A
authors.initials: A
authors.lastname: Aydin
authors.forename: A
authors.initials: A
authors.lastname: Elnaggar
authors.forename: L
authors.initials: L
authors.lastname: Robertson
authors.forename: M
authors.initials: M
authors.lastname: Keating
authors.forename: Y
authors.initials: Y
authors.lastname: Huh