title: Extent of liver resection for hilar cholangiocarcinoma (Klatskin tumor): how much is enough?
abstract: BACKGROUND
  Hilar resection in combination with extended liver resections has resulted in a higher rate of R0 resections and increased survival in patients with hilar cholangiocarcinoma (HCCA). This aggressive surgical approach is, however, associated with high rates of operative morbidity and mortality, largely due to postresectional liver failure. We previously reported a series after resection of HCCA in which R0 resection rate was 59% with a mortality rate of 10%. In this study, we assessed mortality of extended liver resections after optimizing liver functional reserve and application of parenchyma-sparing techniques.
  
  
  METHODS
  From 2008 until June 2010, 41 consecutive patients underwent resection on the suspicion of HCCA. Preoperative workup included staging laparoscopy, preoperative biliary drainage, assessment of volume/function of future remnant liver and radiation therapy to prevent seeding metastases. Modified right and left extended hemihepatectomies were performed preserving parts of segments 4 and 8, respectively, while pursuing complete excision of the tumor. Outcomes of resection were evaluated.
  
  
  RESULTS
  The majority of resections (78%) were performed for Bismuth type III-IV tumors. Preoperative biliary drainage was undertaken in 37 (90%) patients. Hilar resection in combination with liver resection was performed in 35 (85%) patients. Of these resections, 61% were modified extended resections including central liver resections. The R0 resection rate was 92%. Postoperative morbidity and mortality rates were 54 and 7%, respectively.
  
  
  CONCLUSIONS
  Strategies to optimize liver function and to reduce removal of functional liver parenchyma were associated with a decrease in mortality (7%) while undertaking extended resection for HCCA with an R0 resection rate of 92%.
authors.affiliation: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: van Gulik
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Ruys
authors.forename: Oliver R C
authors.initials: OR
authors.lastname: Busch
authors.forename: Erik A J
authors.initials: EA
authors.lastname: Rauws
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: Gouma
mesh_terms: D001646:Bile; D018281:Cholangiocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D004322:Drainage / Q000379:methods; D006498:Hepatectomy / Q000379:methods* / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D008099:Liver / Q000502:physiology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*