title: The relationship between adiponectin, ageing and renal function in a bi-ethnic sample.
abstract: Ageing is associated with elevated adiponectin levels. Our aim was to assess whether age-related increase in adiponectin is associated with a decrease in renal function. The study comprised African (N=277) and Caucasian (N=326) men and women. Adiponectin levels, estimated creatinine clearance rate and obesity indices were determined. African men revealed significantly higher adiponectin levels compared to Caucasian men (p<0.01), reflecting the lower adiposity levels of the African men. No difference in obesity measures (p=0.92) and adiponectin levels (p=0.27) was observed between African and Caucasian women. A significant increase in adiponectin levels with ageing was observed in both African men and women (p<0.01). To the contrary, progressive ageing seems not to be significantly related to elevated adiponectin levels within Caucasians. Renal impairment decreased significantly within all of the groups (p<0.01). Single regression analyses performed in all specified groups revealed significant associations between adiponectin and estimated creatinine clearance, however a multiple regression model revealed that insulin resistance had the strongest association with adiponectin within all the groups. In conclusion, age-related rise in adiponectin levels observed in Africans may not be due to renal impairment.
authors.affiliation: Hypertension in Africa Research Team, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.
authors.forename: I M
authors.initials: IM
authors.lastname: Kruger
authors.forename: H W
authors.initials: HW
authors.lastname: Huisman
authors.forename: A E
authors.initials: AE
authors.lastname: Schutte
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000328:Adult; D000375:Aging / Q000502:physiology*; D044383:Black People; D001837:Body Weights and Measures; D003404:Creatinine / Q000493:pharmacokinetics; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D044465:White People
chemical_list: D052242:Adiponectin; D003404:Creatinine