title: Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase.
abstract: Series of chromone containing sulfonamides were prepared by the reaction of (un)substituted 3-formylchromones with 3-aminobenzenesulfonamide and 4-aminobenzenesulfonamide. Bovine carbonic anhydrase (bCA) inhibitory activity of these newly synthesized compounds was determined. All compounds were active and possessed excellent bCA inhibitory activities with IC₅₀ values ranged between 4.31 ± 0.001 and 29.12 ± 0.008 μmol. Compounds derived from 6-fluoro-3-formylchromones were the most active.
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan. maria_al_rashida@hotmail.com
authors.forename: Mariya
authors.initials: M
authors.lastname: al-Rashida
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.forename: Bushra
authors.initials: B
authors.lastname: Hussain
authors.forename: Saeed Ahmad
authors.initials: SA
authors.lastname: Nagra
authors.forename: Ghulam
authors.initials: G
authors.lastname: Abbas
mesh_terms: D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002256:Carbonic Anhydrases / Q000737:chemistry* / Q000378:metabolism; D002417:Cattle; D002867:Chromones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D002867:Chromones; D013449:Sulfonamides; D002256:Carbonic Anhydrases