title: Toxic effects of nine polycyclic aromatic compounds on Enchytraeus crypticus in artificial soil in relation to their properties.
abstract: The aim of this study was to compare the toxic effects of selected two- and three-ringed PAHs (naphthalene, phenanthrene, and anthracene) and their N-heterocyclic analogs with one (quinoline, acridine, and phenanthridine) or two (quinoxaline, phenazine, and 1,10-phenanthroline) nitrogen atoms on the survival and reproduction of Enchytraeus crypticus in artificial soil. Toxicity of compounds was recalculated to soil pore-water concentrations using the data of chemical analyses of 0.01 M CaCl(2) extracts of spiked soils. When toxicity was based on molar concentrations in pore water (μmol/L), it significantly increased with increasing K(ow) value. This relationship indicates nonpolar narcosis as the general toxicity mechanism of the tested compounds. In addition, significant correlation between the toxicity of PACs and their ionization potential has been identified by multidimensional QSAR models.
authors.affiliation: Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 126/3, Brno, CZ-62500, Czech Republic.
authors.forename: Klára
authors.initials: K
authors.lastname: Kobetičová
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Simek
authors.forename: Jan
authors.initials: J
authors.lastname: Brezovský
authors.forename: Jakub
authors.initials: J
authors.lastname: Hofman
mesh_terms: D000166:Acridines / Q000633:toxicity; D000818:Animals; D000873:Anthracenes / Q000737:chemistry / Q000633:toxicity; D009584:Nitrogen / Q000633:toxicity; D009835:Oligochaeta / Q000187:drug effects*; D010616:Phenanthrenes / Q000737:chemistry / Q000633:toxicity; D010618:Phenanthrolines / Q000737:chemistry / Q000633:toxicity; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000633:toxicity*; D021281:Quantitative Structure-Activity Relationship; D011804:Quinolines / Q000633:toxicity; D012098:Reproduction / Q000187:drug effects; D012987:Soil / Q000032:analysis; D012989:Soil Pollutants / Q000737:chemistry / Q000633:toxicity*
chemical_list: D000166:Acridines; D000873:Anthracenes; D010616:Phenanthrenes; D010618:Phenanthrolines; D011084:Polycyclic Aromatic Hydrocarbons; D011804:Quinolines; D012987:Soil; D012989:Soil Pollutants; C031181:phenanthrene; C037219:quinoline; C034020:anthracene; D009584:Nitrogen; C025205:1,10-phenanthroline