title: Circadian rhythms: biological clocks work in phospho-time.
abstract: The 24 hour molecular oscillator requires precisely calibrated degradation of core clock proteins, like PERIOD. New studies shed light on a sequential series of PERIOD phosphorylation events that first inhibits, then accelerates PERIOD degradation.
authors.affiliation: Washington University Medical School, Saint Louis, MO 63110, USA.
authors.forename: Laura B
authors.initials: LB
authors.lastname: Duvall
authors.forename: Paul H
authors.initials: PH
authors.lastname: Taghert
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000378:metabolism* / Q000502:physiology; D004330:Drosophila; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation
chemical_list: D056925:Circadian Rhythm Signaling Peptides and Proteins