title: Serum high-sensitivity C-reactive protein, amyloid associated protein and N-terminal proBNP levels do not predict reversible myocardial ischaemia.
abstract: OBJECTIVE
  The aim of this study was to detect any relationship between serum high-sensitivity C-reactive protein (hs-CRP), serum amyloid-associated protein (SAA) and N-terminal pro B-type natriuretic peptide (NT-proBNP) levels, and reversible myocardial ischaemia during cardiovascular exercise tests and to determine whether these biomarkers could predict transient myocardial ischaemia.
  
  
  METHODS
  Ninety-six patients (36 women, 60 men, mean age 57 ± 8.5 years) were included in the study. Venous blood samples were taken from patients before and 15 minutes after exercise testing. SAA and hs-CRP were analysed using immunonephelometric assays (Dade-Behring, BN II, Marburg, Germany). NT-proBNP (pg/ml) was determined using the immulite 1 000 chemiluminescence immunoassay system (Siemens Medical Solution Diagnostics, Deerfiled, USA). Forty-eight patients (18 women, 30 men) with positive exercise tests were allocated to the exercise-positive group and 48 (18 women, 30 men) with negative exercise tests were put in the exercise-negative group. Coronary angiography was performed on all patients in the exercise-positive group.
  
  
  RESULTS
  There was no difference between the levels of hs-CRP, SAA and NT-pro-BNP before and after exercise testing in both of the exercise groups.
  
  
  CONCLUSIONS
  Serum levels of hs-CRP, SAA and NT-proBNP could not predict the occurrence of reversible myocardial ischaemia during exercise. Large-scale clinical studies are needed to clarify the status of hs-CRP, SAA and NT-proBNP with exercise.
authors.affiliation: Cardiology Department, Institute of Cardiology, Istanbul University, Haseki, Istanbul. drmuratbaskurt@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Başkurt
authors.forename: F
authors.initials: F
authors.lastname: Aktürk
authors.forename: K
authors.initials: K
authors.lastname: Keskin
authors.forename: P
authors.initials: P
authors.lastname: Canbolat
authors.forename: B
authors.initials: B
authors.lastname: Karadag
authors.forename: A
authors.initials: A
authors.lastname: Kaya
authors.forename: A
authors.initials: A
authors.lastname: Yildiz
authors.forename: U
authors.initials: U
authors.lastname: Coskun
authors.forename: K
authors.initials: K
authors.lastname: Kilickesmez
authors.forename: O
authors.initials: O
authors.lastname: Esen
authors.forename: S K
authors.initials: SK
authors.lastname: Muniboglu
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D000685:Serum Amyloid A Protein / Q000032:analysis
chemical_list: D010446:Peptide Fragments; D000685:Serum Amyloid A Protein; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein