title: Pyrimidine nucleoside phosphorylase-activity and biological characteristics of breast-cancer.
abstract: We investigated whether Pyrimidine nucleoside phosphorylase (PyNPase) activity in breast cancer tissue correlated with biological characteristics of breast cancer. PyNPase activity, ER, PgR, EGFR, DNA ploidy pattern, PCNA positive cells and amplification of the c-erbB-2 gene were determined in specimens from 138 patients. PyNPase activity was significantly higher in ER negative than ER positive carcinomas (p<0.05), in PgR negative than PgR positive carcinomas (p<0.05) and significantly higher in tumors with c-erbB-2 gene amplification compared with tumors with no amplification (p<0.05). The results suggest that PyNPase activity in breast cancer tissue may be a new biological characteristic of breast cancer.
authors.affiliation: OTARU MUNICIPAL HOSP,OTARU,HOKKAIDO,JAPAN. KONAN HOSP,SAPPORO,HOKKAIDO,JAPAN. NATL NISHI SAPPORO HOSP,HOKKAIDO CANC CTR,SAPPORO,HOKKAIDO,JAPAN. SAPPORO MUNICIPAL HOSP,SAPPORO,HOKKAIDO,JAPAN. TENSHI HOSP,FRANCISCAN MISSIONARIES MARY,SAPPORO,HOKKAIDO,JAPAN.
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: J
authors.initials: J
authors.lastname: Uchino
authors.forename: M
authors.initials: M
authors.lastname: Ogita
authors.forename: F
authors.initials: F
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Hata
authors.forename: M
authors.initials: M
authors.lastname: Yoshimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Akasaka
authors.forename: Y
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada