title: Cardiopulmonary function and oxygen delivery during total liquid ventilation.
abstract: BACKGROUND
  Total liquid ventilation (TLV) with perfluorocarbons has shown to improve cardiopulmonary function in the injured and immature lung; however there remains controversy over the normal lung. Hemodynamic effects of TLV in the normal lung currently remain undetermined. This study compared changes in cardiopulmonary and circulatory function caused by either liquid or gas tidal volume ventilation.
  
  
  METHODS
  In a prospective, controlled study, 12 non-injured anesthetized, adult New Zealand rabbits were primarily conventionally gas-ventilated (CGV). After instrumentation for continuous recording of arterial (AP), central venous (CVP), left artrial (LAP), pulmonary arterial pressures (PAP), and cardiac output (CO) animals were randomized into (1) CGV group and (2) TLV group. In the TLV group partial liquid ventilation was initiated with instillation of perfluoroctylbromide (12 ml/kg). After 15 min, TLV was established for 3 hr applying a volume-controlled, pressure-limited, time-cycled ventilation mode using a double-piston configured TLV. Controls (CGV) remained gas-ventilated throughout the experiment.
  
  
  RESULTS
  During TLV, heart rate, CO, PAP, MAP, CVP, and LAP as well as derived hemodynamic variables, arterial and mixed venous blood gases, oxygen delivery, PVR, and SVR did not differ significantly compared to CGV.
  
  
  CONCLUSIONS
  Liquid tidal volumes suitable for long-term TLV in non-injured rabbits do not significantly impair CO, blood pressure, and oxygen dynamics when compared to CGV.
authors.affiliation: Department of Anaesthesiology and Intensive Care Medicine, University Medical Center Mannheim, Mannheim, Germany. charalambos.tsagogiorgas@umm.de
authors.forename: Charalambos
authors.initials: C
authors.lastname: Tsagogiorgas
authors.forename: Markus
authors.initials: M
authors.lastname: Alb
authors.forename: Peter
authors.initials: P
authors.lastname: Herrmann
authors.forename: Michael
authors.initials: M
authors.lastname: Quintel
authors.forename: Juergen P
authors.initials: JP
authors.lastname: Meinhardt
mesh_terms: D000818:Animals; D006321:Heart / Q000502:physiology*; D006439:Hemodynamics; D021061:Liquid Ventilation; D008168:Lung / Q000502:physiology*; D010100:Oxygen / Q000008:administration & dosage* / Q000378:metabolism; D011817:Rabbits
chemical_list: D010100:Oxygen