title: Single-dose-dexketoprofen-induced acute kidney injury due to massive rhabdomyolysis.
abstract: A 70-year-old male patient was admitted complaining of weakness and pain in his arms and lower limbs. His serum creatine kinase and serum creatinine were markedly elevated (36,248 IU/L and 2.8 mg/dL, respectively). He had taken dexketoprofen trometamol because of a common cold, which had developed the previous night. Acute kidney injury caused by dexketoprofen-induced rhabdomyolysis was diagnosed by ruling out other possible causes, such as dermato/polymyositis, myxedema, brucellosis, and hepatitis. Dexketoprofen administration was stopped. As diuresis did not restore spontaneously, the patient was treated with I.V. alkaline solutions and mannitol. Hemodialysis was performed because of anuria and severe metabolic acidosis. The patient's renal function later recovered. In conclusion, dexketoprofen may be a potential risk factor for acute kidney injury and rhabdomyolysis.
authors.affiliation: Department of Nephrology, Kayseri Education and Research Hospital, Kayseri, Turkey.
authors.forename: Tansu
authors.initials: T
authors.lastname: Sav
authors.forename: Aydin
authors.initials: A
authors.lastname: Unal
authors.forename: Abdulsamet
authors.initials: A
authors.lastname: Erden
authors.forename: Ali Ihsan
authors.initials: AI
authors.lastname: Gunal
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000150:complications; D014325:Tromethamine / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; C118296:dexketoprofen trometamol