title: Correlation between Fas and FasL proteins expression in normal gastric mucosa and gastric cancer.
abstract: The study's objective was to assess the expressions of Fas and FasL proteins in gastric cancer in correlation with chosen clinicohistological parameters. Fas and FasL expression was analyzed in 68 patients with gastric cancer, using the immunohistochemical method. The expression of Fas was found to be lower in gastric cancer cells than in healthy mucosa, both in the lining epithelium and in glandular tubes (28% vs. 48% and 44%; p < 0.001). The expression of FasL was also markedly lower in cancer cells than in glandular tubes, yet higher than in the lining epithelium (51% vs. 73% and 14%; p < 0.01). Positive expressions of FasL and Fas were lower in less advanced gastric cancer cells (T1, T2), than in more advanced tumors (T3, T4), but only in the case of FasL was this difference statistically significant (p < 0.05). Our findings seem to confirm the theory of the impact of apoptotic disorders at the level of Fas receptor and FasL protein in the process of gastric cancer formation and growth, which is manifested in the varied expressions of these proteins in gastric cancer and in the normal lining and glandular epithelium of the stomach. However, the lack of significant differences in the expressions of Fas and FasL in correlation to other clinicohistological parameters indicates the existence of mechanisms that have a greater impact on the process of differentiation of gastric cancers. This in our opinion eliminates these proteins as prognostic factors.
authors.affiliation: Department of General and Gastroenterological Surgery, Medical University of Bialystok, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Gryko
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Guzińska-Ustymowicz
authors.forename: Anna
authors.initials: A
authors.lastname: Pryczynicz
authors.forename: Dariusz
authors.initials: D
authors.lastname: Cepowicz
authors.forename: Adam
authors.initials: A
authors.lastname: Kukliński
authors.forename: Jolanta
authors.initials: J
authors.lastname: Czyżewska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kemona
authors.forename: Bogusław
authors.initials: B
authors.lastname: Kędra
mesh_terms: D000328:Adult; D000368:Aged; D053222:Fas Ligand Protein / Q000032:analysis* / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry* / Q000166:cytology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000175:diagnosis; D019014:fas Receptor / Q000032:analysis* / Q000378:metabolism
chemical_list: C491901:FAS protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D019014:fas Receptor