title: Structure inducing ionic liquids-enhancement of alpha helicity in the Abeta(1-40) peptide from Alzheimer's disease.
abstract: We have studied the impact of ionic liquid solvents on the structure of the Abeta(1-40) peptide from Alzheimer's disease and found that ionic liquid solvents were able to induce a conformational change in the structure of the Abeta(1-40) peptide. This conformational change impacts the self-assembly of the peptide into amyloid fibrils.
authors.affiliation: Institute for Technology Research and Innovation, Deakin University, Geelong, Vic 3217, Australia.
authors.forename: Natalie
authors.initials: N
authors.lastname: Debeljuh
authors.forename: Colin J
authors.initials: CJ
authors.lastname: Barrow
authors.forename: Luke
authors.initials: L
authors.lastname: Henderson
authors.forename: Nolene
authors.initials: N
authors.lastname: Byrne
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D002942:Circular Dichroism; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism; D017510:Protein Folding; D017433:Protein Structure, Secondary; D012997:Solvents / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D052578:Ionic Liquids; D010446:Peptide Fragments; D012997:Solvents; C078592:amyloid beta-protein (1-40)