title: THE IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 IN RATS RECEIVING HETEROTOPIC CARDIAC ALLOGRAFTS.
abstract: The immunosuppressive effects of FR 900506 were studied in Lewis rats given ACI heterotopic heart allografts. Intramuscular doses of 0.02 mg/kg daily for 2 weeks extended graft survival slightly, and with doses up to 1.28 mg/kg for 2 weeks, there is long-term graft survival. If only 3 daily doses were given starting on day 4 after transplantation, graft survival for almost 3 months was accomplished in 4 of 6 animals who still bear functioning hearts.
authors.affiliation: Department of Surgery, 3601 Fifth Avenue, Falk Clinic 4 West, Pittsburgh, Pennsylvania 15213.
authors.forename: P
authors.initials: P
authors.lastname: Lee
authors.forename: N
authors.initials: N
authors.lastname: Murase
authors.forename: S
authors.initials: S
authors.lastname: Todo
authors.forename: L
authors.initials: L
authors.lastname: Makowka
authors.forename: T
authors.initials: T
authors.lastname: Starzl