title: Dynamics of GABAρ2 receptors in retinal bipolar neurons and cerebellar astrocytes.
abstract: Gamma-aminobutyric acid (GABA)ρ receptors are selectively targeted to the axon terminals of the retinal bipolar neurons. The traffic of a green fluorescent protein-tagged GABAρ2 was examined in retinal bipolar neurons and cerebellar astrocytes. In bipolar neurons, time-lapse laser confocal microscopy revealed that the fluorescence emitted by GABAρ2-green fluorescent protein accumulates first, in clusters, in the soma and is then distributed along the axon in at least two populations: one that remains relatively immobile and a second population of smaller clusters that moved constantly to and from the axon end. In astrocytes, the fluorescent clusters were relatively immobile and located mainly in the soma.
authors.affiliation: Departamento de Neurobiología Celular y Molecular, Laboratorio de Neurobiología Molecular y Celular, Instituto de Neurobiología-UNAM, Universidad Nacional Autónoma de México, Querétaro, México.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Martínez-Delgado
authors.forename: Daniel
authors.initials: D
authors.lastname: Reyes-Haro
authors.forename: Angeles E
authors.initials: AE
authors.lastname: Espino-Saldaña
authors.forename: Abraham
authors.initials: A
authors.lastname: Rosas-Arellano
authors.forename: Adriana
authors.initials: A
authors.lastname: Pétriz
authors.forename: Patricia
authors.initials: P
authors.lastname: Juárez-Mercado
authors.forename: Ricardo
authors.initials: R
authors.lastname: Miledi
authors.forename: Ataulfo
authors.initials: A
authors.lastname: Martínez-Torres
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001369:Axons / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D018613:Microscopy, Confocal; D021381:Protein Transport; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000378:metabolism*; D051245:Retinal Bipolar Cells / Q000378:metabolism*
chemical_list: D018079:Receptors, GABA