title: The goal of blood pressure control for prevention of early diabetic microvascular complications.
abstract: Lowering blood pressure may confer a benefit to diabetic microvascular complications comparable with glycemic control. Hypertension is causally related to kidney outcomes and is a risk factor for the development of diabetic retinopathy. The prevalence of hypertension increases as kidney disease progresses, so that it coexists with diabetes in up to 80% of those with overt nephropathy. A significant number of patients have hypertension or rising blood pressures in earlier stages, or even before microvascular complications appear. Because microalbuminuria markedly increases the risk of overt nephropathy as well as of cardiovascular complications, primary prevention (i.e., preventing or delaying the onset of microalbuminuria) continues to be explored, predominantly through use of renin-angiotensin blockade. Available data reviewed suggest that primary prevention through blood pressure reduction is more likely to benefit select groups (those with hypertension, cardiovascular risks, or old age). This review discusses the relationship between hypertension, diabetes, and kidney disease, the rationale for primary prevention, and the data that led to that conclusion.
authors.affiliation: Renal Unit, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA. mark.williams@joslin.harvard.edu
authors.forename: Mark E
authors.initials: ME
authors.lastname: Williams
mesh_terms: D000419:Albuminuria / Q000503:physiopathology; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology*; D048909:Diabetes Complications / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D000959:Antihypertensive Agents