title: Adherence to oral chemotherapy in childhood acute lymphoblastic leukemia: an evolutionary concept analysis.
abstract: OBJECTIVE
  To clarify the concept of adherence to daily oral chemotherapy in children with acute lymphoblastic leukemia (ALL), to examine its implications for clinical practice, and to provide a foundation for further research and knowledge development.
  
  
  METHODS
  Published literature identified through the MEDLINE®, CINAHL®, PsycINFO, and ERIC databases.
  
  
  RESULTS
  Identified attributes of adherence to oral chemotherapy in childhood ALL included motivation, persistence, collaboration, mindfulness, cognitive capacity, flexibility, active participation, and identification of key participants in the process. Identified antecedents included a diagnosis of leukemia, the perceived value of adherence, and patient, family, and healthcare system-related factors. Identified consequences included the potential for maintaining optimal drug levels and improving disease outcome, as well as increased patient and caregiver esteem through active participation in the process. Adherence in the context of childhood ALL is defined as the active self-care behavior of taking (or having the responsibility for administering) daily oral chemotherapy, in collaboration with and according to the instructions of the healthcare provider over a defined, prolonged treatment period.
  
  
  CONCLUSIONS
  Adherence to oral chemotherapy in childhood ALL is a complex, multidimensional behavior that involves not only a willingness to follow the prescribed regimen over a prolonged period, but also the cognitive capacity and psychomotor skills to carry out the process.
  
  
  CONCLUSIONS
  Nurses should recognize the importance of clear communication of medication instructions, reinforcement of adherence-related behaviors, and assistance with common issues such as pill-swallowing skills and reminder systems in caring for children with ALL.
authors.affiliation: Center for Cancer Survivorship, Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. wlandier@coh.org
authors.forename: Wendy
authors.initials: W
authors.lastname: Landier
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D055118:Medication Adherence; D009859:Oncology Nursing / Q000379:methods*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000451:nursing*
chemical_list: D000970:Antineoplastic Agents