title: Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines.
abstract: Although dendritic cell (DC)- based cancer vaccines induce effective antitumor activities in murine models, only limited therapeutic results have been obtained in clinical trials. As cancer vaccines induce antitumor activities by eliciting or modifying immune responses in patients with cancer, the Response Evaluation Criteria in Solid Tumors (RECIST) and WHO criteria, designed to detect early effects of cytotoxic chemotherapy in solid tumors, may not provide a complete assessment of cancer vaccines. The problem may, in part, be resolved by carrying out immunologic cellular monitoring, which is one prerequisite for rational development of cancer vaccines. In this review, we will discuss immunologic monitoring of cellular responses for the evaluation of cancer vaccines including fusions of DC and whole tumor cell.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. shigeo_koido@jikei.ac.jp
authors.forename: Shigeo
authors.initials: S
authors.lastname: Koido
authors.forename: Sadamu
authors.initials: S
authors.lastname: Homma
authors.forename: Akitaka
authors.initials: A
authors.lastname: Takahara
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Namiki
authors.forename: Hideo
authors.initials: H
authors.lastname: Komita
authors.forename: Eijiro
authors.initials: E
authors.lastname: Nagasaki
authors.forename: Masaki
authors.initials: M
authors.lastname: Ito
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nagatsuma
authors.forename: Kan
authors.initials: K
authors.lastname: Uchiyama
authors.forename: Kenichi
authors.initials: K
authors.lastname: Satoh
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Ohkusa
authors.forename: Jianlin
authors.initials: J
authors.lastname: Gong
authors.forename: Hisao
authors.initials: H
authors.lastname: Tajiri
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology*; D002459:Cell Fusion; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology*; D006801:Humans; D015166:Monitoring, Immunologic / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D019496:Cancer Vaccines