title: Relationship between abdominal fat and bone mineral density in white and African American adults.
abstract: Several studies have documented relationships between adipose tissue and bone mineral density (BMD); however, the degree to which there are racial differences in this relationship is not known. The purpose of this study was to examine the relationships between abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and BMD among white and African American adults. The sample included 330 white women, 328 African American women, 307 white men, and 116 African American men 18-74 years of age. Dual-energy X-ray absorptiometry scans were used to measure BMD and computed tomography scans were used to measure abdominal VAT and SAT. Linear regression was used to assess the relationships between abdominal adiposity and BMD and to explore possible sex and race differences in the associations. In the total sample as well as in all sex-by-race groups, VAT and SAT were negatively related to BMD, after adjustment for lean body mass (LBM) and several covariates. The VAT model (including covariates) explained 33.3% of the variance in BMD and the SAT model (including covariates) explained 32.7% of the variance in BMD. Being African American, being male, and having high LBM were all associated with higher BMD. Race and sex interactions were not significant, indicating that the relationships were similar across race and sex groups. In conclusion, BMD was inversely related to abdominal VAT and SAT in white and African American adults after adjustment for LBM.
authors.affiliation: Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA. Peter.Katzmarzyk@pbrc.edu
authors.forename: Peter T
authors.initials: PT
authors.lastname: Katzmarzyk
authors.forename: Tiago V
authors.initials: TV
authors.lastname: Barreira
authors.forename: Deirdre M
authors.initials: DM
authors.lastname: Harrington
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Staiano
authors.forename: Steven B
authors.initials: SB
authors.lastname: Heymsfield
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Gimble
mesh_terms: D050153:Abdominal Fat / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000368:Aged; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D044465:White People; D055815:Young Adult