title: Expression of E-cadherin in 230 infiltrating ductal breast carcinoma.
abstract: The immunohistochemical expression of E-cadherin (E-CD) was correlated to differentiation grade, tumor size, axillary lymph node metastasis, hormone receptor status and disease outcome in 230 infiltrating ductal breast carcinomas. E-CD expression was reduced in 116 tumors (50.4%). Reduced E-CD expression was more frequently found in high histological grade and progesterone receptor negative tumors. In contrast, preserved E-CD expression was more frequently observed in tumors with axillary lymph node metastasis, particularly in the group of patients with 1 to 3 positive lymph nodes. A weak association between reduced E-CD expression and shortened overall survival was found in univariate survival analysis, that was lost when the patients were adjusted for other pathological factors in multivariate analysis. These data indicate that E-CD may be considered a differentiation marker in ductal carcinomas of non special type. However, the relationship between E-CD expression and lymph node metastasis and disease outcome remains to be established.
authors.affiliation: HOSP LA PAZ,DEPT OBSTET & GINECOL,E-28046 MADRID,SPAIN. UNIV AUTONOMA MADRID,FAC MED,CSIC,E-28029 MADRID,SPAIN. UNIV AUTONOMA MADRID,FAC MED,DEPT BIOQUIM,E-28029 MADRID,SPAIN.
authors.forename: C
authors.initials: C
authors.lastname: Gamallo
authors.forename: J
authors.initials: J
authors.lastname: Palacios
authors.forename: N
authors.initials: N
authors.lastname: Benito
authors.forename: M
authors.initials: M
authors.lastname: Limeres
authors.forename: A
authors.initials: A
authors.lastname: Pizarro
authors.forename: A
authors.initials: A
authors.lastname: Suarez
authors.forename: F
authors.initials: F
authors.lastname: Pastrana
authors.forename: A
authors.initials: A
authors.lastname: Cano
authors.forename: F
authors.initials: F
authors.lastname: Calero