title: Deadly teamwork: neural cancer stem cells and the tumor microenvironment.
abstract: Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic networks and the niche microenvironment. The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy.
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44118, USA. lathiaj@ccf.org
authors.forename: Justin D
authors.initials: JD
authors.lastname: Lathia
authors.forename: John M
authors.initials: JM
authors.lastname: Heddleston
authors.forename: Monica
authors.initials: M
authors.lastname: Venere
authors.forename: Jeremy N
authors.initials: JN
authors.lastname: Rich
mesh_terms: D000818:Animals; D002450:Cell Communication; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D005909:Glioblastoma / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D009362:Neoplasm Metastasis; D014411:Neoplastic Stem Cells / Q000502:physiology*; D009423:Nervous System Neoplasms / Q000473:pathology* / Q000503:physiopathology; D055153:Stem Cell Niche / Q000502:physiology*; D059016:Tumor Microenvironment