title: Effect of ω-3 fatty acid on gastrointestinal motility after abdominal operation in rats.
abstract: OBJECTIVE
  To investigate whether ω-3 fatty acid could stimulate gastrointestinal motility after abdominal operation.
  
  
  METHODS
  Wistar rats were randomly divided into 3 group (normal saline group, intralipid group, and ω-3 fatty acid group, n = 18/group) after partial caecectomy and gastrostomosis, each group was divided into 3 groups (POD1, POD3, and POD6, n = 6/group). Serum gastrin (GAS), motilin (MTL), interleukin-1 (IL-1), interleukin-6 (IL-6), tissue necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), gastric emptying rate, and small bowel propulsion rate were measured.
  
  
  RESULTS
  On POD 3, gastric emptying rate and small bowel propulsion rate in ω-3 fatty acid group were higher than those in normal saline group and intralipid group. Serum GAS and MTL levels in ω-3 fatty acid group were higher than those in normal saline group, but serum IL-1, IL-6, TNF-α, and COX-2 levels were lower than those in normal saline group and intralipid group.
  
  
  CONCLUSIONS
  ω-3 fatty acid could accelerate the recovery of gastrointestinal mobility after abdominal operation in rats, mainly by relieving postoperative inflammation.
authors.affiliation: Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jian-Chun
authors.initials: JC
authors.lastname: Yu
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Kang
authors.forename: Guang-Jin
authors.initials: GJ
authors.lastname: Zhu
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000818:Animals; D051546:Cyclooxygenase 2 / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects*; D005755:Gastrins / Q000097:blood; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D009037:Motilin / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015525:Fatty Acids, Omega-3; D005755:Gastrins; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D009037:Motilin; D051546:Cyclooxygenase 2