title: Ethylene-vinyl alcohol copolymer dialyzer membrane reduces protein oxidation in hemodialysis patients.
abstract: BACKGROUND
  Oxidative stress has been implicated in the cardiovascular complications that affect hemodialysis (HD) patients. Ethylene-vinyl alcohol copolymer (EVAL) dialyzer membrane induces less production of reactive oxygen species as compared to conventional dialyzers. We evaluated the impact of EVAL membrane on plasma protein oxidation in HD patients.
  
  
  METHODS
  HD patients treated with cellulose triacetate (CTA) dialyzers were selected. In the first study performed in a 2-month crossover design alternating between CTA and EVAL, nonmercaptalbumin and advanced oxidation protein products levels were measured in the predialysis blood from 10 subjects. In the second study, predialysis plasma myeloperoxidase levels were measured before and after a 2-week EVAL treatment on 12 patients.
  
  
  RESULTS
  Plasma advanced oxidation protein products levels were reduced after a 2-month EVAL treatment and increased again after CTA treatment, although the nonmercaptalbumin proportions were not affected significantly by the change in dialyzer membranes. The following study, a 2-week EVAL treatment, showed the decrease in myeloperoxidase levels immediately before HD.
  
  
  CONCLUSIONS
  The frequent use of EVAL dialyzers has been shown to reduce protein oxidation, possibly through the suppression of circulating phagocytes. This novel biocompatible dialyzer is expected to protect cardiovascular mortality in HD patients.
authors.affiliation: Department of Nephrology and Dialysis, Shizuoka City Hospital, Shizuoka, Japan. matsumoto16@aol.com
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Mukai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Arihara
authors.forename: Takao
authors.initials: T
authors.lastname: Saito
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Kumagai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D018384:Oxidative Stress; D009195:Peroxidase / Q000097:blood; D011145:Polyvinyls / Q000627:therapeutic use*; D011506:Proteins / Q000378:metabolism; D006435:Renal Dialysis / Q000295:instrumentation*; D012709:Serum Albumin / Q000378:metabolism*; D000075462:Serum Albumin, Human
chemical_list: D008567:Membranes, Artificial; D011145:Polyvinyls; D011506:Proteins; D012709:Serum Albumin; C079732:nonmercaptalbumin; C020320:ethylene-vinyl alcohol copolymer; D009195:Peroxidase; D000075462:Serum Albumin, Human