title: Evaluation of sugammadex self-association.
abstract: Sugammadex, a thiolated γCD derivative used as an antagonist of steroidal blockers, was studied with regard to its tendency to self-associate in aqueous solution. Three independent methods - permeation through semi-permeable cellophane membranes, dynamic light scattering, and sedimentation equilibrium analytical ultracentrifugation - were used for this purpose. The results were in agreement with each other and showed no evidence of self-association in a wide sugammadex concentration range from 0.25 to 100mg/ml.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Kurkov
authors.forename: Martin
authors.initials: M
authors.lastname: Messner
authors.forename: Marjoleine
authors.initials: M
authors.lastname: Lucassen
authors.forename: Diels J
authors.initials: DJ
authors.lastname: van den Dobbelsteen
authors.forename: John
authors.initials: J
authors.lastname: den Engelsman
authors.forename: Thorsteinn
authors.initials: T
authors.lastname: Loftsson
mesh_terms: D002476:Cellophane / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D009466:Neuromuscular Blocking Agents / Q000037:antagonists & inhibitors; D019999:Pharmaceutical Solutions / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D000077122:Sugammadex; D013997:Time Factors; D014461:Ultracentrifugation / Q000379:methods; D047408:gamma-Cyclodextrins / Q000032:analysis / Q000737:chemistry*
chemical_list: D009466:Neuromuscular Blocking Agents; D019999:Pharmaceutical Solutions; D012996:Solutions; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D002476:Cellophane