title: Human papilloma virus as a possible factor in the pathogenesis of oral lichen planus.
abstract: BACKGROUND
  Oral lichen planus (OLP) is a common chronic inflammatory mucocutaneous disease. Clinical diagnosis of OLP requires clinical work-up and histologic examination to rule out possible dysplasia and carcinoma. It is possible that oral mucosal viral infections including HPV infection may have a causative role in OLP pathogenesis. The aim of this study was to examine the coincidence of human papilloma virus type 18 and oral lichen planus.
  
  
  METHODS
  This study was a case-control study. Twenty nine paraffinized specimens of previously diagnosed oral lichen planus and 14 paraffinized specimens of nonpathogenic mucosa were studied. Polymerase Chain Reaction (PCR) analyze used for detection of DNA HPV 18. The data were analyzed with SPSS software and Fisher's exact test was used to find the possible relation between HPV18 infection and oral lichen planus.
  
  
  RESULTS
  Nine out of 29 (31.0%) lichen planus samples and one out of 14 (7.1%) controls were HPV 18 positive. No significant correlation (P = 0.128) was observed between HPV18 infection and oral lichen planus.
  
  
  CONCLUSIONS
  According to the findings there might be a co-incidence of human papilloma virus type 18 and oral lichen planus.
authors.affiliation: Associate Professor, Oral Pathology Department and Torabinejad Dental Research center, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Sayed Mohammad
authors.initials: SM
authors.lastname: Razavi
authors.forename: Parichehr
authors.initials: P
authors.lastname: Ghalayani
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Salehi
authors.forename: Hajar
authors.initials: H
authors.lastname: Attarzadeh
authors.forename: Mahdi
authors.initials: M
authors.lastname: Shahmoradi