title: Differentiable contributions of human amygdalar subregions in the computations underlying reward and avoidance learning.
abstract: To understand how the human amygdala contributes to associative learning, it is necessary to differentiate the contributions of its subregions. However, major limitations in the techniques used for the acquisition and analysis of functional magnetic resonance imaging (fMRI) data have hitherto precluded segregation of function with the amygdala in humans. Here, we used high-resolution fMRI in combination with a region-of-interest-based normalization method to differentiate functionally the contributions of distinct subregions within the human amygdala during two different types of instrumental conditioning: reward and avoidance learning. Through the application of a computational-model-based analysis, we found evidence for a dissociation between the contributions of the basolateral and centromedial complexes in the representation of specific computational signals during learning, with the basolateral complex contributing more to reward learning, and the centromedial complex more to avoidance learning. These results provide unique insights into the computations being implemented within fine-grained amygdala circuits in the human brain.
authors.affiliation: Trinity College Institute of Neuroscience and School of Psychology, Trinity College, Dublin, Ireland. jdoherty@caltech.edu
authors.forename: Charlotte
authors.initials: C
authors.lastname: Prévost
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: McCabe
authors.forename: Ryan K
authors.initials: RK
authors.lastname: Jessup
authors.forename: Peter
authors.initials: P
authors.lastname: Bossaerts
authors.forename: John P
authors.initials: JP
authors.lastname: O'Doherty
mesh_terms: D000328:Adult; D000679:Amygdala / Q000033:anatomy & histology* / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001519:Behavior / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology; D009483:Neuropsychological Tests; D012201:Reward; D055815:Young Adult