title: Murine cerebral malaria: histopathology and ICAM 1 immunohistochemistry of the inner ear.
abstract: OBJECTIVE
  To evaluate the pathophysiologic changes in the inner ear during the course of severe cerebral malaria in an established animal model, C57 BL/6J mice.
  
  
  METHODS
  This study aims to examine the hearing threshold, the histological changes and ICAM-1 expression in the murine cochlea.
  
  
  RESULTS
  Four of seven mice showed an expected hearing loss of 20 dB or more. The light microscopy of the inner ear did not show any morphologic alterations. The immunohistochemical analysis for ICAM-1 showed intensive staining in the stria vascularis of sick animals and hardly any reaction in healthy controls.
  
  
  CONCLUSIONS
  The up-regulation of ICAM-1 in the stria vascularis - generating the endocochlear potential - suggests its involvement in plasmodial infection.
authors.affiliation: Department of Otorhinolaryngology, Innsbruck Medical University, Innsbruck, Austria. joachim.schmutzhard@i-med.ac.at
authors.forename: Joachim
authors.initials: J
authors.lastname: Schmutzhard
authors.forename: Christian Hermann
authors.initials: CH
authors.lastname: Kositz
authors.forename: Peter
authors.initials: P
authors.lastname: Lackner
authors.forename: Christian
authors.initials: C
authors.lastname: Pritz
authors.forename: Rudolf
authors.initials: R
authors.lastname: Glueckert
authors.forename: Marlene
authors.initials: M
authors.lastname: Fischer
authors.forename: Erich
authors.initials: E
authors.lastname: Schmutzhard
authors.forename: Annelies
authors.initials: A
authors.lastname: Schrott-Fischer
mesh_terms: D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D034381:Hearing Loss / Q000378:metabolism*; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D016779:Malaria, Cerebral / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D010962:Plasmodium berghei; D013316:Stria Vascularis / Q000378:metabolism*
chemical_list: D018799:Intercellular Adhesion Molecule-1