title: A new and facile method to prepare uniform hollow MnO/functionalized mSiO₂ core/shell nanocomposites.
abstract: Trifunctional uniform nanoparticles comprising a manganese nanocrystal core and a functionalized mesoporous silica shell (MnO@mSiO(2)(Ir)@PEG, where Ir is an emissive iridium complex and PEG is polyethylene glycol) have been strategically designed and synthesized. The T(1) signal can be optimized by forming hollow core (H-MnO@mSiO(2)(Ir)@PEG) via a novel and facile etching process, for which the mechanism has been discussed in detail. Systematic investigation on correlation for longitudinal relaxation (T(1)) versus core shapes and shell silica porosity of the nanocomposites (MnO, H-MnO, MnO@SiO(2), MnO@mSiO(2), H-MnO@mSiO(2)) has been carried out. The results show that the worm-like nanochannels in the mesoporous silica shell not only increase water permeability to the interior hollow manganese oxide core for T(1) signal but also enhance photodynamic therapy (PDT) efficacy by enabling the free diffusion of oxygen. Notably, the H-MnO@mSiO(2)(Ir)@PEG nanocomposite with promising r(1) relaxivity demonstrates its versatility, in which the magnetic core provides the capability for magnetic resonance imaging, while the simultaneous red phosphorescence and singlet oxygen generation from the Ir complex are capable of providing optical imaging and inducing apoptosis, respectively.
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
authors.forename: Yung-Kang
authors.initials: YK
authors.lastname: Peng
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Lai
authors.forename: Chien-Liang
authors.initials: CL
authors.lastname: Liu
authors.forename: Hsieh-Chih
authors.initials: HC
authors.lastname: Chen
authors.forename: Yi-Hsuan
authors.initials: YH
authors.lastname: Hsiao
authors.forename: Wei-Liang
authors.initials: WL
authors.lastname: Liu
authors.forename: Kuo-Chun
authors.initials: KC
authors.lastname: Tang
authors.forename: Yun
authors.initials: Y
authors.lastname: Chi
authors.forename: Jong-Kai
authors.initials: JK
authors.lastname: Hsiao
authors.forename: Kun-Eng
authors.initials: KE
authors.lastname: Lim
authors.forename: Hung-En
authors.initials: HE
authors.lastname: Liao
authors.forename: Jing-Jong
authors.initials: JJ
authors.lastname: Shyue
authors.forename: Pi-Tai
authors.initials: PT
authors.lastname: Chou
mesh_terms: D003460:Crystallization / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry; D017895:Manganese Compounds / Q000737:chemistry*; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances; D017895:Manganese Compounds; D010087:Oxides; C009495:titanium dioxide; C027424:manganese oxide; D012822:Silicon Dioxide; D014025:Titanium