title: Near-infrared light-responsive core-shell nanogels for targeted drug delivery.
abstract: A near-infrared light-responsive drug delivery platform based on Au-Ag nanorods (Au-Ag NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity has been applied to develop a polyacrylamide-based sol-gel transition system to encapsulate anticancer drugs into the gel scaffold. The Au-Ag NR-based nanogels can also be readily functionalized with targeting moieties, such as aptamers, for specific recognition of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au-Ag NRs leads to a rapid rise in the temperature of the surrounding gel, resulting in the fast release of the encapsulated payload with high controllability. In vitro study confirmed that aptamer-functionalized nanogels can be used as drug carriers for targeted drug delivery with remote control capability by NIR light with high spatial/temporal resolution.
authors.affiliation: Center For Research at the Bio/nano Interface, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States.
authors.forename: Huaizhi
authors.initials: H
authors.lastname: Kang
authors.forename: Anna Carolina
authors.initials: AC
authors.lastname: Trondoli
authors.forename: Guizhi
authors.initials: G
authors.lastname: Zhu
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Ya-Jen
authors.initials: YJ
authors.lastname: Chang
authors.forename: Haipeng
authors.initials: H
authors.lastname: Liu
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Huang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Zhang
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
mesh_terms: D002460:Cell Line; D003432:Cross-Linking Reagents / Q000737:chemistry; D003470:Culture Media; D004247:DNA / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D005434:Flow Cytometry / Q000379:methods; D006046:Gold / Q000737:chemistry; D006801:Humans; D007259:Infrared Rays; D008027:Light; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012821:Silanes / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013696:Temperature
chemical_list: D003432:Cross-Linking Reagents; D003470:Culture Media; D004337:Drug Carriers; D011108:Polymers; D012821:Silanes; D012834:Silver; D006046:Gold; D004247:DNA