title: Conserved domains, conserved residues, and surface cavities of C-reactive protein (CRP).
abstract: C-reactive protein (CRP) is a highly conserved plasma protein belonging to pentraxins, a superfamily which has significant proinflammatory role. Therefore, CRP can be a good target for drug discovery to prevent disease pathogenesis, especially cardioprotection in acute myocardial infarction and neuroprotection in stroke. Hence, the knowledge of the structure of CRP is very important. In this paper, we have demonstrated three-dimensional structure, conserved domains, and surface structure of human CRP with the help of bioinformatics analysis. We have also depicted that evolutionary relationship of CRP exists among the different species. Simultaneously, WebLogo has been generated to know the more conserved part of this medically important protein.
authors.affiliation: Medical Biotechnology Division, School of Bio-Sciences and Technology, VIT University, Vellore, India.
authors.forename: Suggula Varun
authors.initials: SV
authors.lastname: Kumar
authors.forename: Roshini Kulampurathu
authors.initials: RK
authors.lastname: Ravunny
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002097:C-Reactive Protein / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics; D002316:Cardiotonic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D019295:Computational Biology / Q000379:methods*; D017124:Conserved Sequence / Q000235:genetics; D055808:Drug Discovery / Q000379:methods*; D019143:Evolution, Molecular; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009203:Myocardial Infarction / Q000188:drug therapy / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D040901:Proteomics / Q000379:methods*; D020521:Stroke / Q000188:drug therapy
chemical_list: D002316:Cardiotonic Agents; D018696:Neuroprotective Agents; D002097:C-Reactive Protein