title: "There is no dose-response relationship in psychopharmacotherapy" vs "pharmacotherapy in psychiatry is based on ligand-receptor interaction": a unifying hypothesis and the need for plasma concentration based clinical trials.
authors.affiliation: Experimental Psychiatry Unit, Center of Psychiatry and Psychotherapy, Department of General Psychiatry and Social Psychiatry, Medical University Innsbruck, Innrain 66 a, room 35-G1-010, A-6020, Innsbruck, Austria.
authors.forename: Vincent
authors.initials: V
authors.lastname: Eggart
authors.forename: Christoph
authors.initials: C
authors.lastname: Hiemke
authors.forename: Gerald
authors.initials: G
authors.lastname: Zernig
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D008024:Ligands; D008960:Models, Psychological; D011485:Protein Binding; D011600:Psychopharmacology / Q000379:methods; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use
chemical_list: D000929:Antidepressive Agents, Tricyclic; D008024:Ligands; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; C493230:SLC6A4 protein, human