title: Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene.
abstract: Systemic sclerosis (SSc) is characterized by vascular injuries, and bosentan has recently been proved to be efficacious for the prevention of new digital ulcers in SSc. We herein report a case of SSc in a patient with refractory digital ulcers and gangrene treated with bosentan. Stenosis of the ulnar artery, evaluated by magnetic resonance angiography, was attenuated by the bosentan treatment, suggesting that bosentan exerts a reverse remodeling effect against the pathological organic changes of arteries in SSc.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ichimura
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Masaru
authors.initials: M
authors.lastname: Hatano
authors.forename: Zenshiro
authors.initials: Z
authors.lastname: Tamaki
authors.forename: Tomonori
authors.initials: T
authors.lastname: Takekoshi
authors.forename: Asako
authors.initials: A
authors.lastname: Kogure
authors.forename: Manabu
authors.initials: M
authors.lastname: Tomita
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Kawashima
authors.forename: Miki
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Takehiro
authors.initials: T
authors.lastname: Takahashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitsui
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugaya
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yao
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kinugawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D000077300:Bosentan; D005260:Female; D005385:Fingers / Q000098:blood supply* / Q000473:pathology; D005734:Gangrene / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects*; D045743:Scleroderma, Diffuse / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012883:Skin Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D013449:Sulfonamides; D000077300:Bosentan