title: Label-free discrimination of normal and fibroadenomal breast tissues using second harmonic generation imaging.
abstract: Early detection of fibroadenoma (FA) is critical for preventing subsequent breast cancer. In this work, we show that label-free second harmonic generation (SHG) imaging is feasible and effective in quantitatively differentiating the fibroadenomal tissue from normal breast tissue. With the advent of the clinical portability of miniature SHG microscopy, we believe that the technique has great potential in offering a noninvasive in vivo imaging tool for early detection of FA and monitoring the treatment responses of FA in clinics.
authors.affiliation: Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Zheng
authors.forename: Shuangmu
authors.initials: S
authors.lastname: Zhuo
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Zhu
authors.forename: Xingshan
authors.initials: X
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Yan
authors.forename: Jianxin
authors.initials: J
authors.lastname: Chen
authors.forename: Shusen
authors.initials: S
authors.lastname: Xie
mesh_terms: D000328:Adult; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology; D003094:Collagen / Q000737:chemistry; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D018613:Microscopy, Confocal / Q000379:methods*; D008875:Middle Aged
chemical_list: D003094:Collagen