title: Neurovirulence tests of three 17D yellow fever vaccine strains.
abstract: The results of tests of the neurovirulence of three yellow fever vaccine preparations of different lineages are presented. Two preparations that have been used to make vaccines of acceptable safety and efficacy gave very similar results. A third preparation from the Robert Koch Institute, designated 168-73, was proposed as a reference preparation for the mouse potency assay in 1985 by WHO, but has been more often used as a reference in the monkey neurovirulence test. In the test described here 168-73 was of lower virulence than either of the other two preparations.
authors.affiliation: National Institute of Biological Standards and Control, Health Protection Agency, South Mimms, Potters Bar, Hertfordshire, United Kingdom. Philip.Minor@nibsc.hpa.org.uk
authors.forename: Philip D
authors.initials: PD
authors.lastname: Minor
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D001921:Brain / Q000473:pathology; D008252:Macaca fascicularis; D051379:Mice; D013116:Spinal Cord / Q000473:pathology; D014774:Virulence / Q000276:immunology; D014776:Virus Cultivation; D015004:Yellow Fever / Q000276:immunology / Q000517:prevention & control; D022341:Yellow Fever Vaccine / Q000633:toxicity*; D015005:Yellow fever virus / Q000276:immunology / Q000472:pathogenicity
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D022341:Yellow Fever Vaccine