title: The effect of live, attenuated measles vaccine and measles infection on measles antibody levels in serum and CSF of patients with multiple sclerosis or clinically isolated syndrome.
abstract: High occurrence of measles, rubella and varicella zoster antibodies has been used as a biomarker for MS (the MRZ test). We analyzed measles antibody titres with respect to measles infection/measles vaccination status in 166 patients with MS or clinically isolated syndrome. Fifty blood donors served as controls. Measles vaccination yielded CSF measles antibodies in fewer patients (62%) than measles infection did (87%, p=0.001) and yielded lower measles titres in both serum and CSF (p<0.001). Controls had lower CSF measles titres than patients with measles vaccination alone (p<0.001). Childhood vaccinations probably reduce the sensitivity of the MRZ diagnostic test for MS.
authors.affiliation: Institute of Neuroscience and Physiology, Department of Neurology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden. cecilia.ahlgren@neuro.gu.se
authors.forename: Cecilia
authors.initials: C
authors.lastname: Ahlgren
authors.forename: Anders
authors.initials: A
authors.lastname: Odén
authors.forename: Sara
authors.initials: S
authors.lastname: Haghighi
authors.forename: Oluf
authors.initials: O
authors.lastname: Andersen
authors.forename: Tomas
authors.initials: T
authors.lastname: Bergström
authors.forename: Jan
authors.initials: J
authors.lastname: Lycke
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood* / Q000134:cerebrospinal fluid*; D002675:Child, Preschool; D003711:Demyelinating Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008457:Measles / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D008458:Measles Vaccine / Q000276:immunology* / Q000627:therapeutic use; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine; D014613:Vaccines, Attenuated