title: Sustained elite suppression of replication competent HIV-1 in a patient treated with rituximab based chemotherapy.
abstract: The mechanism of elite control of HIV-1 replication is not fully understood. While immunosuppression due to rituximab based chemotherapy has been associated with increased replication of HBV, CMV, and HIV-1, control of replication-competent HIV-1 was maintained in an elite controller/suppressor treated with a regimen that included vincristine, cyclophosphamide, prednisone, four rounds of plasmapheresis and ten cycles of rituximab. The data suggests that de-novo antibody responses do not play a significant role in the control of viral replication in these patients.
authors.affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Gaillard
authors.forename: Jason B
authors.initials: JB
authors.lastname: Dinoso
authors.forename: Julia A
authors.initials: JA
authors.lastname: Marsh
authors.forename: Amy E
authors.initials: AE
authors.lastname: DeZern
authors.forename: Karen A
authors.initials: KA
authors.lastname: O'Connell
authors.forename: Adam M
authors.initials: AM
authors.lastname: Spivak
authors.forename: Karla
authors.initials: K
authors.lastname: Alwood
authors.forename: Christine M
authors.initials: CM
authors.lastname: Durand
authors.forename: Richard F
authors.initials: RF
authors.lastname: Ambinder
authors.forename: Joel N
authors.initials: JN
authors.lastname: Blankson
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage*; D004358:Drug Therapy / Q000379:methods; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D000069283:Rituximab; D017422:Sequence Analysis, DNA
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007166:Immunosuppressive Agents; D000069283:Rituximab