title: Organocatalytic asymmetric halogenation/semipinacol rearrangement: highly efficient synthesis of chiral α-oxa-quaternary β-haloketones.
abstract: A novel asymmetric halogenation/semipinacol rearrangement reaction catalyzed by cinchona alkaloid derivatives was developed. Two types of β-haloketones (X = Br, Cl) were obtained with up to 95% yield and 99% enantiomeric excess. The desired (+) and (-) enantiomers of the β-haloketones were readily obtained.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry & Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Chen
authors.forename: Qing-Wei
authors.initials: QW
authors.lastname: Zhang
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Tu
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Zhang
authors.forename: Jin-Miao
authors.initials: JM
authors.lastname: Tian