title: Pulsatile multiparticulate drug delivery system for metoprolol succinate.
abstract: Cardiovascular diseases and their treatment pose a great challenge. Many instances of cardiovascular disease occur in the early morning hours. Hence, the objective of this study was to develop a time-controlled release formulation of metoprolol succinate based on a pulsatile multiparticulate (pellets) drug delivery system. The formulation was intended to be administered in the evening at 22:00 hours to evaluate symptoms of cardiovascular disease that are experienced in the early morning hours (from 04:00 to 06:00). Drug layering followed by a swelling layer and finally by an insoluble coat application was done using a Sanmour fluid bed processor. Metoprolol succinate layered on sugar pellets (74% w/w) layered with 20% (w/w) ion doshion resin P-547 and coated with 15% (w/w) ethocel with the addition of 20% castor oil showed a lag time of 4 h and was then followed a sigmoidal release pattern with more than 95% drug having been released by the 10(th) h.
authors.affiliation: MAEER's Maharashtra Institute of Pharmacy, Pune, Maharashtra, India. jagdaleswati@rediffmail.com
authors.forename: Swati C
authors.initials: SC
authors.lastname: Jagdale
authors.forename: Sachin M
authors.initials: SM
authors.lastname: Chede
authors.forename: Ram
authors.initials: R
authors.lastname: Gulwady
authors.forename: Bhanudas S
authors.initials: BS
authors.lastname: Kuchekar
authors.forename: Pradeep D
authors.initials: PD
authors.lastname: Lokhande
authors.forename: Tejas P
authors.initials: TP
authors.lastname: Shah
authors.forename: Anuruddha R
authors.initials: AR
authors.lastname: Chabukswar
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D055870:Drug Chronotherapy; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D006801:Humans; D008790:Metoprolol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012995:Solubility
chemical_list: D000319:Adrenergic beta-Antagonists; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008790:Metoprolol