title: The relationship between the Trp 64 Arg polymorphism of the beta 3-adrenoceptor gene and idiopathic overactive bladder.
abstract: OBJECTIVE
  The purpose of this study was to verify the association between the Trp 64 Arg polymorphism and idiopathic overactive bladder (OAB) syndrome.
  
  
  METHODS
  A case-control study was conducted with 218 women. The case group consisted of 49 patients with OAB symptoms; the control group included 169 women without urinary symptoms. The studied polymorphism was detected by restriction fragment length polymorphism analysis. The χ(2) test was used to compare categoric data, with a significance level of 5%. Numeric data were compared with the use of the parametric t test or nonparametric Mann-Whitney U test.
  
  
  RESULTS
  The distribution of the polymorphism in the investigated women was digested homozygous T allele 69.75%, heterozygotes 29.8%, and homozygous A allele 0.45%. A comparison between the groups showed higher prevalence of the digested homozygous T allele genotype in women with OAB syndrome (P = .001). Multiple logistic regression analysis identified that a family history of OAB syndrome was an independent risk factor for OAB syndrome.
  
  
  CONCLUSIONS
  The Trp 64 Arg polymorphism was associated with OAB syndrome in the Brazilian population.
authors.affiliation: Section of Urogynecology and Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, Brazil.
authors.forename: Cristina E
authors.initials: CE
authors.lastname: Ferreira
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Fonseca
authors.forename: Ismael D
authors.initials: ID
authors.lastname: Silva
authors.forename: Manoel J
authors.initials: MJ
authors.lastname: Girão
authors.forename: Marair G
authors.initials: MG
authors.lastname: Sartori
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Castro
mesh_terms: D000368:Aged; D001120:Arginine / Q000235:genetics; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D014364:Tryptophan / Q000235:genetics; D053201:Urinary Bladder, Overactive / Q000453:epidemiology / Q000235:genetics*
chemical_list: D022702:Receptors, Adrenergic, beta-3; D014364:Tryptophan; D001120:Arginine