title: Treatment of oral squamous cell carcinoma with accelerated radiation therapy and concomitant carboplatin in cats.
abstract: BACKGROUND
  Feline oral squamous cell carcinoma (SCC) carries a very poor prognosis with traditional treatments.
  
  
  OBJECTIVE
  To examine the effectiveness of adding carboplatin to a previously published accelerated radiation protocol in the treatments of oral SCC in cats.
  
  
  METHODS
  Thirty-one cases of oral SCC in cats. Tumor sites included lingual (n = 9), mandible (n = 10), maxilla (n = 7), tonsil (n = 4), and cheek (n = 1).
  
  
  METHODS
  Prospective trial using a planned radiation protocol consisting of 14 fractions of 3.5 Gy given within a 9-day period with the addition of carboplatin given at 90-100 mg/m(2) on day 1 and day 4.5. Treatments were twice daily with a 6-hour delay between treatments. All cats presenting with oral SCC without evidence of distant metastasis were eligible.
  
  
  RESULTS
  Median survival for all cats was 163 days (range 53-770 days) with a mean of 319 ± 53 days with significant predictors of survival being site (P = .004) and whether there was a complete response at 30 days (P = .001). Cats with tumors of tonsil origin or cheek responded best to therapy and were long-term survivors with a mean survival of 724 days and the median had not been reached because of continued survival of 4 cats.
  
  
  CONCLUSIONS
  This protocol offers an aggressive yet tolerable treatment of oral SCC in cats that might offer improved survival as compared with previously reported treatments. The long-term survival of cats with tonsillar SCC has not been reported previously.
authors.affiliation: Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164-6610, USA. jfidel@vetmed.wsu.edu
authors.forename: J
authors.initials: J
authors.lastname: Fidel
authors.forename: J
authors.initials: J
authors.lastname: Lyons
authors.forename: C
authors.initials: C
authors.lastname: Tripp
authors.forename: R
authors.initials: R
authors.lastname: Houston
authors.forename: B
authors.initials: B
authors.lastname: Wheeler
authors.forename: A
authors.initials: A
authors.lastname: Ruiz
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000662:veterinary*; D002371:Cat Diseases / Q000188:drug therapy / Q000532:radiotherapy*; D002415:Cats; D003131:Combined Modality Therapy / Q000662:veterinary; D005260:Female; D008297:Male; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin