title: Actin depolymerizing effect of trisoxazole-containing macrolides.
abstract: Oxazole-containing macrolides (1-5) isolated from the marine sponge Chondrosia corticata were evaluated for their actin depolymerizing activities by monitoring fluorescent intensity of pyrene F-actin. These studies led to the identification of (19Z)-halichondramide (5) as a new actin depolymerizing agent. The actin depolymerizing activity by (19Z)-halichondramide (5) was four times more potent than that of halichondramide (1). Compounds 1 and 5 also have potent antifungal activity. The preliminary structure-activity relationship of these compounds is described to elucidate the essential structural requirements.
authors.affiliation: Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-921, Republic of Korea.
authors.forename: Soon-Chun
authors.initials: SC
authors.lastname: Chung
authors.forename: So-Hyoung
authors.initials: SH
authors.lastname: Lee
authors.forename: Kyoung Hwa
authors.initials: KH
authors.lastname: Jang
authors.forename: Wanki
authors.initials: W
authors.lastname: Park
authors.forename: Ju-eun
authors.initials: JE
authors.lastname: Jeon
authors.forename: Hana
authors.initials: H
authors.lastname: Oh
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005453:Fluorescence; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology; D058105:Polymerization / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: C495172:(19Z)-halichondramide; D000935:Antifungal Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D018942:Macrolides; D010080:Oxazoles; C470372:halichondramide