title: Engineering plant resistance by constructing chimeric receptors that recognize damage-associated molecular patterns (DAMPs).
abstract: An efficient sensing of danger and a rapid activation of the immune system are crucial for the survival of plants. Conserved pathogen/microbe-associated molecular patterns (PAMPs/MAMPs) and endogenous molecular patterns, which are present only when the tissue is infected or damaged (damage-associated molecular patterns or DAMPs), can act as danger signals and activate the plant immune response. These molecules are recognized by surface receptors that are indicated as pattern recognition receptors (PRRs). In this paper we summarize recent information on oligogalacturonides (OGs), a class of DAMPs that is released from the extracellular matrix of the plant cell during pathogen attack or wounding. We also describe the characteristics of the Arabidopsis Wall-Associated Kinase 1 (WAK1), a PRR recently identified as a receptor of OGs and discuss the use of WAK1, PRRs and chimeric receptors to engineer resistance in crop plants.
authors.affiliation: Istituto Pasteur-Cenci-Bolognetti, Dipartimento di Biologia e Biotecnologie C. Darwin, Sapienza Università di Roma, Rome, Italy. giulia.delorenzo@uniroma1.it
authors.forename: Giulia
authors.initials: G
authors.lastname: De Lorenzo
authors.forename: Alexandre
authors.initials: A
authors.lastname: Brutus
authors.forename: Daniel Valentin
authors.initials: DV
authors.lastname: Savatin
authors.forename: Francesca
authors.initials: F
authors.lastname: Sicilia
authors.forename: Felice
authors.initials: F
authors.lastname: Cervone
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D029681:Arabidopsis Proteins / Q000378:metabolism; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008969:Molecular Sequence Data; D010368:Pectins / Q000378:metabolism; D010944:Plants / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D008565:Membrane Proteins; D051192:Receptors, Pattern Recognition; D011993:Recombinant Fusion Proteins; D010368:Pectins; D011494:Protein Kinases; C101093:WAK1 protein, Arabidopsis