title: A randomized, double-blind, placebo-controlled trial of levetiracetam for dyskinesia in Parkinson's disease.
abstract: BACKGROUND
  This randomized double blind, placebo-controlled crossover study investigated the antidyskinetic effects of levetiracetam in Parkinson's disease.
  
  
  METHODS
  Sixteen participants with levodopa-induced dyskinesia were enrolled. Hourly videotaped dyskinesia assessments scored by the Goetz method and hourly Unified Parkinson's Disease Rating Scale motor subscale scoring were conducted on 1 day at the end of each treatment period.
  
  
  RESULTS
  Dyskinesia was slightly less on placebo (P = .26). Patient diary records also showed less dyskinesia on placebo (P = .10). Parkinsonism was a little worse on levetiracetam, at borderline statistical significance (P = .05).
  
  
  CONCLUSIONS
  Levetiracetam was well tolerated at doses up to 2000 mg per day, but we did not detect any antidyskinetic properties.
authors.affiliation: Neurosciences Department, Monash Medical Centre, Melbourne, Australia.
authors.forename: Kitty K
authors.initials: KK
authors.lastname: Wong
authors.forename: Jane E
authors.initials: JE
authors.lastname: Alty
authors.forename: Amanda G
authors.initials: AG
authors.lastname: Goy
authors.forename: Sanjay
authors.initials: S
authors.lastname: Raghav
authors.forename: David C
authors.initials: DC
authors.lastname: Reutens
authors.forename: Peter A
authors.initials: PA
authors.lastname: Kempster
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D000978:Antiparkinson Agents / Q000009:adverse effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D006801:Humans; D000077287:Levetiracetam; D007980:Levodopa / Q000009:adverse effects; D010300:Parkinson Disease / Q000188:drug therapy; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012720:Severity of Illness Index; D013997:Time Factors; D014741:Video Recording
chemical_list: D000927:Anticonvulsants; D000978:Antiparkinson Agents; D000077287:Levetiracetam; D007980:Levodopa; D010889:Piracetam