title: Technetium-99m-labeled autologous serum albumin: a personal-exclusive source of serum component.
abstract: Technetium-99m human serum albumin ((99m)Tc-HSA) is an important radiopharmaceutical required in nuclear medicine studies. However, the risk of transfusion-transmitted infection remains a major safety concern. Autopreparation of serum component acquired from patient provides a "personal-exclusive" source for radiolabeling. This paper is to evaluate the practicality of on-site elusion and subsequent radiolabeling efficacy for serum albumin. Results showed that the autologous elute contained more albumin fraction than serum without extraction procedure. Good radiochemical purity and stability were demonstrated after radiolabeling. Biodistribution study showed that labeled albumin accumulated immediately in the lung, liver, and kidney. It was cleared steadily and excreted in the urine. The biologic half-life was defined, and all samples passed the pyrogenicity and sterility tests. In conclusion, autoalbumin could be extracted and radiolabeled properly in a nuclear medicine setting. Moreover, the risk of transfusion-transmitted infection associated with nonautologous, multisource (99m)Tc-HSA agents can be reduced.
authors.affiliation: College of Medicine, Tzu Chi University, Hualien, Taiwan. yuhfeng@gmail.com
authors.forename: Yuh-Feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.forename: Dian-Kun
authors.initials: DK
authors.lastname: Li
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Chuang
mesh_terms: D000818:Animals; D005591:Chemical Fractionation; D004355:Drug Stability; D006801:Humans; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D044967:Serum / Q000737:chemistry*; D013668:Technetium Tc 99m Aggregated Albumin / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics; D013696:Temperature; D014018:Tissue Distribution
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin