title: [Death of tumor cells. Photodynamic reaction in apoptosis induction in cancer cells].
abstract: The main purpose of current anticancer methods is to initiate intracellular mechanisms leading to cell death (apoptosis or necrosis). The most required way of cell death is apoptosis. It is genetically caused process of active cell destruction. Cells undergo apoptosis without losing integrity, lysis, inflammation and damage of neighboring cells. There are formed apoptotic bodies from death cells. Apoptotic bodies are taken up by phagocytes and neighboring cells, which may also activate an anti-inflammatory response, at least in macrophages. There are three stages of apoptosis: decision, commitment and execution phase with inner and outer pathways. The significant role play cysteine proteases called caspases. Caspases are proteolytically activated heterodimer enzymes. The cascade of caspases play the key role in executive phase of apoptosis. However, p53 also is crucial in cell death. Is protein as a transcription factor can modulate gene expression coding proteins involved in apoptosis regulation. Photodynamic therapy (PDT) is a promising technique in anticancer therapies. It requires three crucial components for initiation of photodynamic reaction: a photosensitizer that selectively bounds with tumor cells; oxygen and a source of proper light for dye excitation. In many studies are shown that photosensitizers localized in mitochondria induced are apoptosis inductors, in contrast to these dyes localized in lysosomes and cytoplasmatic membrane.
authors.affiliation: Akademia Medyczna we Wrocławiu, Katedra i Zakład Biochemii Lekarskiej.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Chwiłkowska
authors.forename: Julita
authors.initials: J
authors.lastname: Kulbacka
authors.forename: Jolanta
authors.initials: J
authors.lastname: Saczko
mesh_terms: D000818:Animals; D020169:Caspases / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D010778:Photochemotherapy; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D020169:Caspases