title: Psychosocial interventions for late-life major depression: evidence-based treatments, predictors of treatment outcomes, and moderators of treatment effects.
abstract: This systematic review evaluates the efficacy of psychosocial interventions for the acute treatment of late-life depression and identifies predictors of treatment outcomes and moderators of treatment effects. Problem-solving therapy, cognitive behavioral therapy, and treatment initiation and participation program have supportive evidence of efficacy, pending replication. Although the data on predictors of treatment outcomes and moderators of treatment effects are preliminary, it appears that baseline anxiety and stress level, personality disorders, endogenous depression, and reduced self-rated health predict worse depression outcomes. Future research may examine the moderating effects of baseline depression severity and identify other clinical or demographic moderators.
authors.affiliation: Department of Psychiatry, Weill-Cornell Medical College, 21 Bloomingdale Road, White Plains, NY 10605, USA. dkiosses@med.cornell.edu
authors.forename: Dimitris N
authors.initials: DN
authors.lastname: Kiosses
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Leon
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Areán
mesh_terms: D000368:Aged; D000375:Aging / Q000523:psychology*; D003071:Cognition; D015928:Cognitive Behavioral Therapy / Q000379:methods / Q000639:trends; D003865:Major Depressive Disorder / Q000523:psychology* / Q000628:therapy*; D019317:Evidence-Based Medicine / Q000639:trends*; D006801:Humans; D011340:Problem Solving; D011613:Psychotherapy / Q000379:methods / Q000639:trends; D012944:Social Support; D016896:Treatment Outcome