title: [Pulmonary manifestations of polyvinyl chloride exposure].
abstract: There is currently no national data on the effects of polyvinyl chloride (PVC) exposure on pulmonary function. In this study we recruited workers and administrative staff from two PVC plants between July 2008 and July 2009. A questionnaire, pulmonary function tests, carbon monoxide diffusion capacity, and peak flows were recorded. Particulate matter analyses were performed by the Adana Central Laboratory of the Directorate of Occupational Health and Safety. Data were analyzed with SPSS 13.0 software. Nine of the 147 subjects were female. The incidence of a cough was more common in the administrative group. Of the study population, 59.1% were smokers. Tobacco addiction significantly increased cough and dyspnea [OR= 1.10 (1.00-1.20, 95% CI) p= 0.007 and OR= 1.08 (1.02-1.14, 95% CI), p= 0.008, respectively]. Dust exposure was correlated with the incidence of a cough [OR= 0.20 (0.04-0.80, 95% CI) p= 0.008]. The period of work correlated with sputum production [OR= 1.00 (1.00-1.02, 95% CI) p= 0.044]. The FVC% was significantly higher in the administrative group, and FEV1/FVC and DLCO were higher in the exposed group. Tobacco addiction increased the risk of airflow limitation, as evaluated by FEV1/FVC < 70% and FEF25-75 < 50% [OR= 1.15 (1.06-1.25, 95% CI) p= 0.001 and OR= 1.09 (1.02-1.17, 95% CI) p= 0.010, respectively]. Tobacco addiction and increasing duration of work had a negative influence on DLCO in the exposed group (r= -0.270, p= 0.025 and r= -0.210, p= 0.037). In the exposed group PEF variability was significantly greater on workdays, compared with rest days. This study shows that tobacco consumption has a greater affect on the airways than PVC dust exposure. A median of 36 months exposure to PVC dust had no significant impact on pulmonary function parameters, except for DLCO and PEF variability.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Süyür
authors.forename: Nazan
authors.initials: N
authors.lastname: Bayram
authors.forename: Neriman
authors.initials: N
authors.lastname: Aydın
authors.forename: Meral
authors.initials: M
authors.lastname: Uyar
authors.forename: Nevhiz
authors.initials: N
authors.lastname: Gündoğdu
authors.forename: Osman
authors.initials: O
authors.lastname: Elbek
mesh_terms: D000328:Adult; D002248:Carbon Monoxide / Q000378:metabolism; D003371:Cough / Q000139:chemically induced / Q000453:epidemiology; D004058:Diffusion; D004391:Dust; D004417:Dyspnea / Q000139:chemically induced / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008171:Lung Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D016273:Occupational Exposure / Q000009:adverse effects*; D052638:Particulate Matter / Q000032:analysis; D010366:Peak Expiratory Flow Rate; D011143:Polyvinyl Chloride / Q000009:adverse effects*; D012129:Respiratory Function Tests; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014029:Tobacco Use Disorder / Q000150:complications / Q000453:epidemiology; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004391:Dust; D052638:Particulate Matter; D002248:Carbon Monoxide; D011143:Polyvinyl Chloride