title: Effect of dietary factors in pregnancy on risk of pregnancy complications: results from the Norwegian Mother and Child Cohort Study.
abstract: There has been a thrilling development , as well as profound changes, in our understanding of the effect of fetal nutrition on the development and health of the child. The Norwegian Mother and Child Cohort Study (MoBa) is an ongoing nationwide population-based pregnancy cohort study that between 1999 and 2008 recruited 90,723 women with 106,981 pregnancies and 108,487 children. The objective of MoBa is to test specific etiologic hypotheses by estimating the association between exposures and diseases with a special focus on disorders that may originate in early life. An important aspect in this regard is maternal diet and nutritional status during pregnancy. Nutritional factors have long been considered to be important determinants of maternal and fetal health, and dietary information is currently being collected in a number of pregnancy cohorts in Europe and the United States. Thus far, pregnancy complications studied in MoBa are preterm birth, preeclampsia, and fetal growth; and the aim of this article is to report results of recently published studies of dietary factors in relation to these outcomes. Numerous studies are planned using MoBa data, and the aim is to add to the knowledge of the interplay between dietary factors, nonnutrients, and toxic dietary substances and epigenetic modulation on fetal development and health later in life.
authors.affiliation: Divisions of Environmental Medicine and Epidemiology, Norwegian Institute of Public Health, Oslo, Norway. helle.margrete.meltzer@fhi.no
authors.forename: Helle Margrete
authors.initials: HM
authors.lastname: Meltzer
authors.forename: Anne Lise
authors.initials: AL
authors.lastname: Brantsæter
authors.forename: Roy M
authors.initials: RM
authors.lastname: Nilsen
authors.forename: Per
authors.initials: P
authors.lastname: Magnus
authors.forename: Jan
authors.initials: J
authors.lastname: Alexander
authors.forename: Margareta
authors.initials: M
authors.lastname: Haugen
mesh_terms: D001724:Birth Weight; D038441:Diet, Mediterranean; D005247:Feeding Behavior; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D009664:Norway / Q000453:epidemiology; D015596:Nutrition Assessment; D009752:Nutritional Status; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D047928:Premature Birth / Q000378:metabolism; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000008:administration & dosage; D044465:White People
chemical_list: D014807:Vitamin D; D005492:Folic Acid