title: Interactions between proteins and platinum-containing anti-cancer drugs.
abstract: Cisplatin and its congeners are well-known to exert their therapeutic effects on cancer via interaction with DNA in the cell nucleus. On the other hand, the undesirable side-effects of these drugs appear to also be linked, at least to some extent, to interaction of the platinum with proteins and peptides. For other classes of anticancer drugs, interaction with proteins is in fact the primary pathway whereby therapeutically-useful effects are achieved. Here, a review is given of the known instances of interaction of cisplatin and related compounds with proteins and biologically relevant peptides, with emphasis on structural and reactivity aspects.
authors.affiliation: Department of Chemistry and Chemical Engineering, Babes-Bolyai University, 11 Arany Janos str, Cluj-Napoca RO-400028, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bischin
authors.forename: Alexandru
authors.initials: A
authors.lastname: Lupan
authors.forename: Vicentiu
authors.initials: V
authors.lastname: Taciuc
authors.forename: Radu
authors.initials: R
authors.lastname: Silaghi-Dumitrescu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D002945:Cisplatin / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D011506:Proteins; D002945:Cisplatin