title: Foods and food groups associated with the incidence of colorectal polyps: the Adventist Health Study.
abstract: Colorectal cancer (CRC) is a leading cause of cancer death in the United States. The majority of CRC arise in adenomatous polyps and 25-35% of colon adenoma risk could be avoidable by modifying diet and lifestyle habits. We assessed the association between diet and the risk of self-reported physician-diagnosed colorectal polyps among 2,818 subjects who had undergone colonoscopy. Subjects participated in 2 cohort studies: the AHS-1 in 1976 and the AHS-2 from 2002-2005. Multivariate logistic regression analysis was used to estimate the period risk of incident cases of polyps; 441 cases of colorectal polyps were identified. Multivariate analysis adjusted by age, sex, body mass index, and education showed a protective association with higher frequency of consumption of cooked green vegetables (OR 1 time/d vs. <5/wk = 0.76, 95% CI = 0.59-0.97) and dried fruit (OR 3+ times/wk vs. <1 time/wk = 0.76, 95%CI = 0.58-0.99). Consumption of legumes at least 3 times/wk reduced the risk by 33% after adjusting for meat intake. Consumption of brown rice at least 1 time/wk reduced the risk by 40%. These associations showed a dose-response effect. High frequency of consumption of cooked green vegetables, dried fruit, legumes, and brown rice was associated with a decreased risk of colorectal polyps.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Loma Linda University, Loma Linda, California 92350, USA. ytantamango@hotmail.com
authors.forename: Yessenia M
authors.initials: YM
authors.lastname: Tantamango
authors.forename: Synnove F
authors.initials: SF
authors.lastname: Knutsen
authors.forename: W Lawrence
authors.initials: WL
authors.lastname: Beeson
authors.forename: Gary
authors.initials: G
authors.lastname: Fraser
authors.forename: Joan
authors.initials: J
authors.lastname: Sabate
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003111:Colonic Polyps / Q000453:epidemiology* / Q000517:prevention & control; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D004032:Diet; D007887:Fabaceae; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D005638:Fruit; D006801:Humans; D015994:Incidence; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012275:Oryza; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D057566:Self Report; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology; D014675:Vegetables