title: Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals.
abstract: Metallic radionuclides are the mainstay of both diagnostic and therapeutic radiopharmaceuticals. Therapeutic nuclear medicine is less advanced but has tremendous potential if the radionuclide is accurately targeted. Great interest exists in the field of inorganic chemistry for developing target specific radiopharmaceuticals based on radiometals for non-invasive disease detection and cancer radiotherapy. This perspective will focus on the nuclear properties of a few important radiometals and their recent applications to developing radiopharmaceuticals for imaging and therapy. Other topics for discussion will include imaging techniques, radiotherapy, analytical techniques, and radiation safety. The ultimate goal of this perspective is to introduce inorganic chemists to the field of nuclear medicine and radiopharmaceutical development, where many applications of fundamental inorganic chemistry can be found.
authors.affiliation: Applied and Developmental Research Directorate, SAIC-Frederick, National Cancer Institute (NIH/NCI) at Frederick, 1050 Boyles Street, Bldg. 376, Frederick, Maryland, USA. bhattacharyyas2@mail.nih.gov
authors.forename: Sibaprasad
authors.initials: S
authors.lastname: Bhattacharyya
authors.forename: Manish
authors.initials: M
authors.lastname: Dixit
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D008670:Metals / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000627:therapeutic use; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D056831:Coordination Complexes; D008670:Metals; D019275:Radiopharmaceuticals