title: Mammalian Sirt1: insights on its biological functions.
abstract: Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-associated metabolic diseases, cancer, adipose tissue, aging, cellular senescence, cardiac aging and stress, prion-mediated neurodegeneration, inflammatory signaling in response to environmental stress, development and placental cell survival.
authors.affiliation: Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia -7003, Bangladesh. rezwangbt@yahoo.com.
authors.forename: Shahedur
authors.initials: S
authors.lastname: Rahman
authors.forename: Rezuanul
authors.initials: R
authors.lastname: Islam