title: Neurotrophic effect of submicrosomal fractions obtained from pre-degenerated peripheral nerves.
abstract: Submicrosomal fractions obtained from pre-degenerated distal stumps of sciatic nerves were implanted by means of connective tissue chambers into the injured hippocampus for 8 and 18 weeks. The nerve stumps were allowed to pre-degenerate for 7, 28 and 35 days. The neuronal outgrowth was examined by means of FITC-HRP injected into the chamber. Eight weeks postoperatively the greatest number of traced cells was present in brains treated with the fraction obtained from nerves pre-degenerated for 7 days. Eighteen weeks following implantation the greatest number of FITC-HRP positive cells was found in brains grafted with the fraction from nerves pre-degenerated for 35 days.
authors.affiliation: Department of Physiology, Silesian Medical School, ul. Medyków 18, 40-762 Katowice, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Lewin-Kowalik
authors.forename: J J
authors.initials: JJ
authors.lastname: Barski
authors.forename: M
authors.initials: M
authors.lastname: Krause
authors.forename: D
authors.initials: D
authors.lastname: Górka
authors.forename: B
authors.initials: B
authors.lastname: Golka
authors.forename: M
authors.initials: M
authors.lastname: Larysz-Brysz