title: [Significance of aquaporin-1 and aquaporin-3 expression in colorectal carcinoma].
abstract: OBJECTIVE
  To investigate the significance of aquaporin-1(AQP-1) and aquaporin-3(AQP-3) in the development of colorectal carcinoma.
  
  
  METHODS
  The expression of AQP-1 and AQP-3 was investigated using immunohistochemical staining with Streptavidin Peroxidase in tissues from colorectal adenoma (CRA, n=25), colorectal cancer (CRC, n=50), and adjacent mucosa (CRT, n=50).
  
  
  RESULTS
  The positive rate of AQP-1 was 64%(32/50) in CRC, significantly higher than that in CRT (38%, 19/50) and CRA(32%, 8/25)(P<0.05). The expression of AQP-1 was associated with depth of invasion and lymph node metastasis in CRC patients(P<0.05). The positive rate of AQP-3 was 56% in CRT, 44% in CRA, and 52% in CRC. There were no significant differences (P>0.05). The expression of AQP-3 was associated with age, tumor diameter, and depth of invasion (P<0.05). No significant correlation between the expression of AQP-1 and AQP-3 in CRC was shown by Spearman correlation analysis(P>0.05).
  
  
  CONCLUSIONS
  AQP-1 expression is increased in CRC while the expression of AQP-3 is not. There is no correlation between the expression of AQP-1 and AQP-3 in CRC.
authors.affiliation: Deparatment of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Hai-ping
authors.initials: HP
authors.lastname: Pei
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Liu
authors.forename: Lin-sheng
authors.initials: LS
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D051398:Aquaporin 1 / Q000378:metabolism*; D051400:Aquaporin 3 / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: C496020:AQP1 protein, human; C496027:AQP3 protein, human; D051398:Aquaporin 1; D051400:Aquaporin 3