title: Pleomorphic adenoma with extensive squamous metaplasia and keratin cyst formations in minor salivary gland: a case report.
abstract: Pleomorphic adenoma (PA), the most common salivary gland tumor, accounts for 54 to 65% of all salivary gland neoplasias and 80% of the benign salivary gland tumors. It most frequently affects the parotid gland, followed by the submandibular and the minor salivary glands. Microscopically, mucous, sebaceous, oncocytic and squamous metaplasia, sometimes with the formation of keratin pearls, may be present, but the latter rarely results in the formation of extensive keratin-filled cysts lined by squamous epithelium. Extensive squamous metaplasia can be mistaken for malignancy, including mucoepidermoid carcinoma and squamous cell carcinoma. Here, we present an unusual case of PA with extensive squamous metaplasia and keratin cyst formations in a minor salivary gland, and discuss its microscopic features, including the immunohistochemical characteristics, and differential diagnosis of this uncommon presentation.
authors.affiliation: Department of Stomatology (Oral Pathology), Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil. mariacarolinaodonto@yahoo.com.br
authors.forename: Maria Carolina Vaz
authors.initials: MC
authors.lastname: Goulart
authors.forename: Patrícia
authors.initials: P
authors.lastname: Freitas-Faria
authors.forename: Gláuter Rodrigues
authors.initials: GR
authors.lastname: Goulart
authors.forename: Adriano Macedo de
authors.initials: AM
authors.lastname: Oliveira
authors.forename: Roman
authors.initials: R
authors.lastname: Carlos-Bregni
authors.forename: Cleverson Teixeira
authors.initials: CT
authors.lastname: Soares
authors.forename: Vanessa Soares
authors.initials: VS
authors.lastname: Lara
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000328:Adult; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000096:biosynthesis; D008297:Male; D008679:Metaplasia; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology*
chemical_list: D007633:Keratins