title: Lymphangiogenesis in post-natal tissue remodeling: lymphatic endothelial cell connection with its environment.
abstract: The main physiological function of the lymphatic vasculature is to maintain tissue fluid homeostasis. Lymphangiogenesis or de novo lymphatic formation is closely associated with tissue inflammation in adults (i.e. wound healing, allograft rejection, tumor metastasis). Until recently, research on lymphangiogenesis focused mainly on growth factor/growth factor-receptor pathways governing this process. One of the lymphatic vessel features is the incomplete or absence of basement membrane. This close association of endothelial cells with the underlying interstitial matrix suggests that cell-matrix interactions play an important role in lymphangiogenesis and lymphatic functions. However, the exploration of interaction between extracellular matrix (ECM) components and lymphatic endothelial cells is in its infancy. Herein, we describe ECM-cell and cell-cell interactions on lymphatic system function and their modification occurring in pathologies including cancer metastasis.
authors.affiliation: Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Cancer GIGA-Cancer, University of Liège, B-4000 Liège, Belgium.
authors.forename: Jenny
authors.initials: J
authors.lastname: Paupert
authors.forename: Nor Eddine
authors.initials: NE
authors.lastname: Sounni
authors.forename: Agnès
authors.initials: A
authors.lastname: Noël
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D042783:Endothelial Cells / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D042583:Lymphangiogenesis / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology