title: Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence.
abstract: Personality traits like novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are known to be moderately heritable (30-60%). These personality traits and their comorbidities, such as alcohol dependence (AD), may share genetic components. We examined 11,120 single nucleotide polymorphisms (SNPs) genotyped in 292 nuclear families from the Genetic Analysis Workshop 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). A family-based association analysis was performed using the FBAT program. NS, HA, and RD were treated as quantitative traits and AD as a binary trait. Based on a multivariate association test of three quantitative traits in FBAT, we observed 20 SNPs with p < 10(-3). Interestingly, several genes (TESK2, TIPARP, THEMIS, ABLIM1, RFX4, STON2 and LILRA1) are associated with three personality traits with p < 10(-3) using single trait analysis and AD. Especially, SNP rs727532 within ABLIM1 gene at 10q25 showed the most significant association (p = 6.4 × 10(-5)) in the multivariate test and strong associations with NS, HA, RD, and AD (p = 4.48 × 10(-4), 1.2 × 10(-5), 5.6 × 10(-5), 3.12 × 10(-4), respectively) in the COGA sample. In addition, the association of rs727532 with AD was confirmed in a replication study. This study reports some newly recognized associations between several genetic loci and both AD and three personality traits.
authors.affiliation: Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, PO Box 70259, Lamb Hall, Johnson City, TN, 37614-1700, USA. wangk@etsu.edu
authors.forename: Ke-Sheng
authors.initials: KS
authors.lastname: Wang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Liu
authors.forename: Nagesh
authors.initials: N
authors.lastname: Aragam
authors.forename: Jerald E
authors.initials: JE
authors.lastname: Mullersman
authors.forename: Xueqiu
authors.initials: X
authors.lastname: Jian
authors.forename: Yue
authors.initials: Y
authors.lastname: Pan
authors.forename: Yali
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000437:Alcoholism / Q000235:genetics; D016022:Case-Control Studies; D015331:Cohort Studies; D005106:Exploratory Behavior; D005190:Family; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D060588:LIM Domain Proteins / Q000235:genetics* / Q000502:physiology; D008297:Male; D008840:Microfilament Proteins / Q000235:genetics* / Q000502:physiology; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory; D020641:Polymorphism, Single Nucleotide; D012201:Reward; D018401:Sample Size; D011795:Surveys and Questionnaires; D014481:United States; D044465:White People / Q000235:genetics
chemical_list: C107440:ABLIM1 protein, human; D060588:LIM Domain Proteins; D008840:Microfilament Proteins