title: Novel polymeric/lipidic hybrid systems (PLHs) for effective Cidofovir delivery: preparation, characterization and comparative in vitro study with polymeric particles and liposomes.
abstract: Cidofovir is an antiviral drug active as antitumoral agent a high doses against the Primary Effusion Lymphoma, a herpesvirus HHV8-associated B-cell lymphoma. A novel polymeric/lipidic hybrid system, consisting in a specific combination of biocompatible materials, capable to build a crossbred between polymeric particles and liposomes were prepared and used to stabilize and deliver the drug, unsuccessfully formulated into several types of carriers. This innovative cidofovir-delivering system has structurally been characterized in comparison to multilamellar liposomes and polymeric particles, and then tested for antitumoral efficacy against tumor cells (BCBL-1 cell line). The results demonstrated the improving of drug stability and encapsulation efficiency and suggested that polymeric/lipidic hybrid system could be promising to improve the antitumoral effect of cidofovir even at lower doses.
authors.affiliation: Department of Pharmaceutical Sciences, Via Campi 183, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Belletti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Riva
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tosi
authors.forename: Flavio
authors.initials: F
authors.lastname: Forni
authors.forename: Patrizia
authors.initials: P
authors.lastname: Barozzi
authors.forename: Mario
authors.initials: M
authors.lastname: Luppi
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Vandelli
authors.forename: Barbara
authors.initials: B
authors.lastname: Ruozi
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D003890:Desiccation; D004058:Diffusion; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry*; D019288:Herpesvirus 8, Human / Q000187:drug effects; D006801:Humans; D008055:Lipids / Q000032:analysis / Q000737:chemistry*; D008081:Liposomes / Q000032:analysis / Q000737:chemistry; D063065:Organophosphonates / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004337:Drug Carriers; D005079:Excipients; D008055:Lipids; D008081:Liposomes; D063065:Organophosphonates; D011091:Polyesters; D011108:Polymers; C033616:poly(lactide); D003596:Cytosine; D000077404:Cidofovir