title: Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor.
abstract: A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
authors.forename: Weiping
authors.initials: W
authors.lastname: Zhu
authors.forename: Yufang
authors.initials: Y
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Dai
authors.forename: Xuhong
authors.initials: X
authors.lastname: Qian
authors.forename: Yuanli
authors.initials: Y
authors.lastname: Li
authors.forename: Jianwen
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000737:chemistry; D016466:CHO Cells; D015687:Cell Hypoxia; D003412:Cricetulus; D004247:DNA / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry*; D053644:Naphthalimides / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D010087:Oxides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D005456:Fluorescent Dyes; D015335:Molecular Probes; D053644:Naphthalimides; D010087:Oxides; D004247:DNA