title: Genome-wide approaches to the study of adaptive gene expression evolution: systematic studies of evolutionary adaptations involving gene expression will allow many fundamental questions in evolutionary biology to be addressed.
abstract: The role of gene expression in evolutionary adaptation has been a subject of debate for over 40 years. cis-regulation of transcription has been proposed to be the primary source of morphological novelty in evolution, though this is based on only a handful of examples. Recently the first genome-wide studies of gene expression adaptation have been published, giving us an initial global view of this process. Systematic studies such as these will allow a number of key questions currently facing the field of gene expression evolution to be addressed.
authors.affiliation: Department of Biology, Stanford University, Stanford, CA, USA. hbfraser@stanford.edu
authors.forename: Hunter B
authors.initials: HB
authors.lastname: Fraser
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D005075:Biological Evolution; D004843:Epistasis, Genetic; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D055106:Genome-Wide Association Study; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D012641:Selection, Genetic