title: Impact of obesity on plasma B-type natriuretic peptide levels in Japanese community-based subjects.
abstract: The plasma B-type natriuretic peptide (BNP) concentration was recently shown to be inversely correlated with body mass index (BMI). However, very few attempts have been made to associate abdominal obesity and BNP in the Japanese general population. Here, we conducted a cross-sectional study, and examined 339 male and 429 female residents without heart disease in a rural Japanese community who received an annual health checkup in 2006. BNP was inversely associated with both BMI and abdominal circumference (AC) in the age-adjusted regression analysis (p < 0.05). Following adjustment for traditional risk factors, multiple regression analysis revealed that BNP was negatively correlated with AC (p < 0.05), but not BMI. Although metabolic syndrome was not associated with BNP levels, AC had an influence on low BNP levels in the multiple regression analysis using both AC and BMI concurrently (p < 0.05 for AC and p > 0.60 for BMI). These effects were more prominent in men than in women. Collectively, plasma BNP levels are inversely related with obesity, as measured by AC, in Japanese community-based subjects.
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Akita University Faculty of Medicine, 1-1-1 Hondo, Akita City, Akita, 010-8543, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Koizumi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Kenji
authors.initials: K
authors.lastname: Iino
authors.forename: Masaru
authors.initials: M
authors.lastname: Ishida
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kosaka
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Motohashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D056128:Obesity, Abdominal / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D012423:Rural Health; D012737:Sex Factors; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain