title: Transcription by RNA polymerase III: more complex than we thought.
abstract: RNA polymerase (Pol) III is highly specialized for the production of short non-coding RNAs. Once considered to be under relatively simple controls, recent studies using chromatin immunoprecipitation followed by sequencing (ChIP-seq) have revealed unexpected levels of complexity for Pol III regulation, including substantial cell-type selectivity and intriguing overlap with Pol II transcription. Here I describe these novel insights and consider their implications and the questions that remain.
authors.affiliation: Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK. r.white@beatson.gla.ac.uk
authors.forename: Robert J
authors.initials: RJ
authors.lastname: White
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D005796:Genes; D006657:Histones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009928:Organ Specificity / Q000235:genetics; D012319:RNA Polymerase II / Q000378:metabolism / Q000502:physiology; D012320:RNA Polymerase III / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*
chemical_list: D006657:Histones; D012319:RNA Polymerase II; D012320:RNA Polymerase III