title: Mild/minimal stimulation for in vitro fertilization: an old idea that needs to be revisited.
abstract: Mild ovarian stimulation for in vitro fertilization usually refers to the use of low-dose gonadotropins in conjunction with a gonadotropin-releasing hormone (GnRH) antagonist whereas minimal stimulation refers to the use of a sequential administration of clomiphene citrate followed by low-dose gonadotropins and a GnRH antagonist. These protocols offer important cost and tolerability advantages to all patients but specifically to high and low responders.
authors.affiliation: Department of Obstetrics and Gynecology, George Washington University School of Medicine, Washington, DC, USA.
authors.forename: Shvetha M
authors.initials: SM
authors.lastname: Zarek
authors.forename: Suheil J
authors.initials: SJ
authors.lastname: Muasher
mesh_terms: D002996:Clomiphene / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000009:adverse effects; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006062:Gonadotropins / Q000008:administration & dosage; D006727:Hormone Antagonists / Q000008:administration & dosage; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology / Q000517:prevention & control*; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D005300:Fertility Agents, Female; D006062:Gonadotropins; D006727:Hormone Antagonists; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone