title: [Novel immunopathological approaches to pulmonary arterial hypertension].
abstract: Inflammation is important for the initiation and the maintenance of vascular remodeling in the most commun animal models of pulmonary hypertension (PH), and its therapeutical targeting blocks PH development in these models. In human, pulmonary vascular lesions of PH are also the source of an intense chemokine production, linked to inflammatory cell recruitment. However, arteritis is uncommon in PH patients. Of note, current PH treatments have immunomodulatory properties. In addition, some studies have shown a correlation between levels of circulating inflammatory mediators and patients' survival. The study of autoimmunity in the pathophysiology of pulmonary arterial hypertension is becoming an area of intense investigation. New immunopathological approaches to PH should allow the development of innovative treatments for this very severe condition.
authors.affiliation: Université Paris-Sud, Faculté de médecine, Le Kremlin-Bicêtre, France. frederic.perros@gmail.com
authors.forename: Frédéric
authors.initials: F
authors.lastname: Perros
authors.forename: David
authors.initials: D
authors.lastname: Montani
authors.forename: Peter
authors.initials: P
authors.lastname: Dorfmüller
authors.forename: Alice
authors.initials: A
authors.lastname: Huertas
authors.forename: Marie-Camille
authors.initials: MC
authors.lastname: Chaumais
authors.forename: Sylvia
authors.initials: S
authors.lastname: Cohen-Kaminsky
authors.forename: Marc
authors.initials: M
authors.lastname: Humbert
mesh_terms: D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000276:immunology*; D007249:Inflammation / Q000150:complications / Q000188:drug therapy