title: Washout of ⁸²Rb as a marker of impaired tissue integrity, obtained by list-mode cardiac PET/CT: relationship with perfusion/metabolism patterns of myocardial viability.
abstract: OBJECTIVE
  Myocardial washout of the potassium analogue (82)Rb may indicate tissue impairment. Few studies have evaluated its usefulness for viability assessment, and controversial results were reported. We revisited this topic using list-mode positron emission tomography (PET)/CT.
  
  
  METHODS
  A total of 22 patients with chronic ischemic cardiomyopathy (ICM) and 11 control subjects with normal CT coronary angiogram were studied. Rest (82)Rb PET/CT studies were acquired in list mode and resampled to static, gated, and dynamic images. Using a 17-segment model, (82)Rb washout was determined by monoexponential fitting of myocardial time-activity curves. In ICM patients, (18)F-fluorodeoxyglucose (FDG) studies were obtained in the same session and segments were classified as normally perfused, mismatch, or matched defect.
  
  
  RESULTS
  (82)Rb washout was minimal and homogeneous in control subjects. Normally perfused segments of ICM did not differ (p = 0.33). ICM patients had a left ventricular ejection fraction (LVEF) of 25 ± 12%, 25/353 mismatched, and 46/353 matched defect segments. (82)Rb washout was higher in hypoperfused vs normal segments (p < 0.05), but not different between mismatch and matched defect (p = 0.18). Intraindividual analysis in nine patients showing both FDG mismatch and matched defect confirmed absence of differences. Overall, segmental (82)Rb washout correlated inversely with (82)Rb uptake (r = -0.70; p < 0.05) and less well with FDG uptake (r = -0.31; p < 0.05).
  
  
  CONCLUSIONS
  Using state-of-the-art PET/CT technology for myocardial viability assessment, (82)Rb washout does not distinguish between perfusion/metabolism patterns of hibernating myocardium and scar. Tissue integrity may be at least partially impaired in hibernation.
authors.affiliation: Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Chien
authors.forename: Paco
authors.initials: P
authors.lastname: Bravo
authors.forename: Takahiro
authors.initials: T
authors.lastname: Higuchi
authors.forename: Jennifer
authors.initials: J
authors.lastname: Merrill
authors.forename: Frank M
authors.initials: FM
authors.lastname: Bengel
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D009202:Cardiomyopathies / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications; D009206:Myocardium / Q000473:pathology*; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012414:Rubidium Radioisotopes / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity; D014022:Tissue Survival; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D012414:Rubidium Radioisotopes