title: Sweet DREAMs for Hippo.
abstract: The Hippo pathway coordinates organ size and cell proliferation. The retinoblastoma family of proteins regulates progression through the G0/G1 phase of the cell cycle. Disruption of either pathway contributes to cancer formation. Three recent studies in Genes & Development reveal how cellular proliferation is coordinated between these pathways. Here we discuss the implications of these studies and the new questions that they raise.
authors.affiliation: London Regional Cancer Program, London, Ontario N6A 4L6, Canada. fdick@uwo.ca
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Dick
authors.forename: Joe S
authors.initials: JS
authors.lastname: Mymryk
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D047108:Embryonic Development / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D051605:Kv Channel-Interacting Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000503:physiopathology; D009929:Organ Size / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000378:metabolism; D050717:Retinoblastoma-Like Protein p130 / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D000097603:Dyrk Kinases
chemical_list: D051605:Kv Channel-Interacting Proteins; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D016160:Retinoblastoma Protein; D050717:Retinoblastoma-Like Protein p130; D000097603:Dyrk Kinases