title: The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans.
abstract: In the mucosa, the immune pathways discriminating between colonizing and invasive Candida, thus inducing tolerance or inflammation, are poorly understood. Th17 responses induced by Candida albicans hyphae are central for the activation of mucosal antifungal immunity. An essential step for the discrimination between yeasts and hyphae and induction of Th17 responses is the activation of the inflammasome by C. albicans hyphae and the subsequent release of active IL-1β in macrophages. Inflammasome activation in macrophages results from differences in cell-wall architecture between yeasts and hyphae and is partly mediated by the dectin-1/Syk pathway. These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans.
authors.affiliation: Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: Shih-Chin
authors.initials: SC
authors.lastname: Cheng
authors.forename: Frank L
authors.initials: FL
authors.lastname: van de Veerdonk
authors.forename: Megan
authors.initials: M
authors.lastname: Lenardon
authors.forename: Monique
authors.initials: M
authors.lastname: Stoffels
authors.forename: Theo
authors.initials: T
authors.lastname: Plantinga
authors.forename: Sanne
authors.initials: S
authors.lastname: Smeekens
authors.forename: Lisa
authors.initials: L
authors.lastname: Rizzetto
authors.forename: Liliane
authors.initials: L
authors.lastname: Mukaremera
authors.forename: Kanya
authors.initials: K
authors.lastname: Preechasuth
authors.forename: Duccio
authors.initials: D
authors.lastname: Cavalieri
authors.forename: Thirumala Devi
authors.initials: TD
authors.lastname: Kanneganti
authors.forename: Jos W M
authors.initials: JW
authors.lastname: van der Meer
authors.forename: Bart Jan
authors.initials: BJ
authors.lastname: Kullberg
authors.forename: Leo A B
authors.initials: LA
authors.lastname: Joosten
authors.forename: Neil A R
authors.initials: NA
authors.lastname: Gow
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
mesh_terms: D001773:Blood Cells / Q000276:immunology / Q000382:microbiology; D002176:Candida albicans / Q000166:cytology / Q000276:immunology* / Q000472:pathogenicity; D002177:Candidiasis / Q000276:immunology; D002478:Cells, Cultured; D006801:Humans; D025301:Hyphae / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism; D037181:Lectins, C-Type; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology* / Q000382:microbiology; D000099181:Dectin-1
chemical_list: D058847:Inflammasomes; D053583:Interleukin-1beta; D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D000099181:Dectin-1