title: Chromatin: constructing the big picture.
abstract: Chromatin is the ensemble of genomic DNA and a large number of proteins. Various genome-wide mapping techniques have begun to reveal that, despite the tremendous complexity, chromatin organization is governed by simple principles. This review discusses the principles that drive the spatial architecture of chromatin, as well as genome-wide-binding patterns of chromatin proteins.
authors.affiliation: Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands. b.v.steensel@nki.nl
authors.forename: Bas
authors.initials: B
authors.lastname: van Steensel
mesh_terms: D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism*; D056890:Eukaryota / Q000235:genetics*; D008954:Models, Biological; D008956:Models, Chemical
chemical_list: D002843:Chromatin