title: High-frequency genetic contents variations in clinical Candida albicans isolates.
abstract: Genome plasticity is a hallmark of Candida albicans and is believed to be an adaptation strategy. But the extent of such genomic variability is not well investigated. In this study, genetic contents of clinical C. albicans isolates were investigated at whole-genome level with array-based comparative genomic hybridization (array CGH) technology. It was revealed that C. albicans possessed variations of genetic contents, as well as aneuploidy. The variable genes were scattered across the chromosomes, as well clustered in particular regions, including sub-telomeric regions, retrotransposon-insertion sites and a variable region on chromosome 6.
authors.affiliation: Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.forename: Tian-Hua
authors.initials: TH
authors.lastname: Yan
authors.forename: Elena
authors.initials: E
authors.lastname: Rustchenko
authors.forename: Ping-Hui
authors.initials: PH
authors.lastname: Gao
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Lan
authors.initials: L
authors.lastname: Yan
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Cao
authors.forename: Qiu-Juan
authors.initials: QJ
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Ji
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Cao
authors.forename: Yuan-Ying
authors.initials: YY
authors.lastname: Jiang
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D001483:Base Sequence; D002176:Candida albicans / Q000235:genetics* / Q000302:isolation & purification / Q000502:physiology; D015825:Chromosomes, Fungal; D055028:Comparative Genomic Hybridization; D017931:DNA Primers; D018628:Gene Dosage; D005800:Genes, Fungal; D016366:Open Reading Frames; D016133:Polymerase Chain Reaction; D018626:Retroelements
chemical_list: D017931:DNA Primers; D018626:Retroelements