title: The possible role of hemochromatosis in testicular cancer.
abstract: Hemochromatosis is a genetic disorder of iron metabolism that results in elevated iron absorption in the intestines, which leads to progressive iron accumulation in a variety of organs. Studies have shown that excessive iron deposits in the liver due to hereditary hemochromatosis leads to cirrhosis, which can put an individual at increased risk for developing hepatocellular carcinoma. Testicular atrophy, sometimes caused by excessive iron deposition in the testes, is a risk factor for testicular cancer. Therefore, the possible role of hereditary hemochromatosis in testicular cancer is explored.
authors.affiliation: Marshfield Clinic, Department of Hematology/Oncology, Weston Center, 3501 Cranberry Boulevard, Weston, WI 54476, USA. onitilo.adedayo@marshfieldclinic.org
authors.forename: A A
authors.initials: AA
authors.lastname: Onitilo
authors.forename: J M
authors.initials: JM
authors.lastname: Engel
authors.forename: S M
authors.initials: SM
authors.lastname: Sajjad
mesh_terms: D016190:Carboplatin / Q000627:therapeutic use; D006432:Hemochromatosis / Q000150:complications* / Q000235:genetics; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense / Q000235:genetics; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D013737:Testis / Q000378:metabolism / Q000473:pathology
chemical_list: D016190:Carboplatin; D007501:Iron