title: Choroidal laser Doppler flowmeter with enhanced sensitivity based on a scattering plate.
abstract: A portable choroidal laser Doppler flowmeter (LDF) with enhanced sensitivity based on a scattering plate is developed. The portable LDF is weighted 2 kg operated at center wavelength of 780 nm, leading to a better penetration into the eye fundus in contrast to the previous LDF operated at center wavelength of 670 nm. Enhancement of number of detected photons that undergo Doppler scattering and improved measured speed of choroidal blood flow are achieved with the use of a scattering plate positioned in front of the eye. The mechanism of detection and sensitivity enhancement is theoretically analyzed. Evaluation of system performance is done by in vivo measurements on ten volunteers. The results demonstrate that an increased percentage of backscattering light at high Doppler shift frequency is collected due to utilization of the scattering plate. However, this kind of light detection influences spatial resolution of the system and decreases the total signal measured. The proposed method for detection and sensitivity enhancement might be useful in a case where the perception of very slight alternation of blood flow is pursued and the spatial resolution is not as critical as that in a choroidal vascular bed.
authors.affiliation: Zhejiang University, State Key Lab of Modern Optical Instrumentation, Yuquan Campus, 38 Zheda Road, Hangzhou 310027, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Ding
authors.forename: Martial
authors.initials: M
authors.lastname: Geiser
authors.forename: Tong
authors.initials: T
authors.lastname: Wu
authors.forename: Minghui
authors.initials: M
authors.lastname: Chen
mesh_terms: D002829:Choroid / Q000098:blood supply*; D004867:Equipment Design; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008027:Light; D008954:Models, Biological; D009010:Monte Carlo Method; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity