title: Engineering microbial factories for synthesis of value-added products.
abstract: Microorganisms have become an increasingly important platform for the production of drugs, chemicals, and biofuels from renewable resources. Advances in protein engineering, metabolic engineering, and synthetic biology enable redesigning microbial cellular networks and fine-tuning physiological capabilities, thus generating industrially viable strains for the production of natural and unnatural value-added compounds. In this review, we describe the recent progress on engineering microbial factories for synthesis of valued-added products including alkaloids, terpenoids, flavonoids, polyketides, non-ribosomal peptides, biofuels, and chemicals. Related topics on lignocellulose degradation, sugar utilization, and microbial tolerance improvement will also be discussed.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Du
authors.forename: Zengyi
authors.initials: Z
authors.lastname: Shao
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhao
mesh_terms: D057005:Bioengineering / Q000191:economics / Q000379:methods* / Q000639:trends; D056804:Biofuels; D001688:Biological Products / Q000378:metabolism*; D001702:Biopharmaceutics / Q000379:methods / Q000639:trends; D004345:Drug Industry; D005419:Flavonoids / Q000378:metabolism; D008031:Lignin / Q000378:metabolism; D060847:Metabolic Engineering / Q000639:trends; D008827:Microbiological Phenomena; D061065:Polyketides / Q000378:metabolism; D015202:Protein Engineering; D058615:Synthetic Biology; D013729:Terpenes / Q000378:metabolism
chemical_list: D056804:Biofuels; D001688:Biological Products; D005419:Flavonoids; D061065:Polyketides; D013729:Terpenes; C036909:lignocellulose; D008031:Lignin