title: Cytolytic and tumor inhibitory antibodies against UK114 protein in the sera of cancer patients.
abstract: UK114 is a 14 kDa protein identified in the perchloric acid soluble extract of goat liver. Anti-UK114 antibodies identify this protein as expressed by the membrane of human cancer cells. In the present study, anti-UK114 antibodies were detected in the sera of cancer patients by ELISA and by immunofluorescence tests using human cancer cell lines as a target. UK114 protein is antigenic in cancer patients. Human anti-UK114 antibodies have cytolytic effects in vitro and their presence correlates with inhibition of growth of human carcinoma cells xenografted in nu/nu mice. This finding may open new prospects for immunotherapy.
authors.affiliation: UNIV TURIN,DEPT MED & SURG SCI,I-10126 TURIN,ITALY. UNIV TURIN,DEPT BIOL & CLIN SCI,I-10126 TURIN,ITALY. UNIV MILAN,G SISINI INST,MILAN,ITALY.
authors.forename: G
authors.initials: G
authors.lastname: Bussolati
authors.forename: M
authors.initials: M
authors.lastname: Geuna
authors.forename: B
authors.initials: B
authors.lastname: Bussolati
authors.forename: M
authors.initials: M
authors.lastname: Millesimo
authors.forename: M
authors.initials: M
authors.lastname: Botta
authors.forename: A
authors.initials: A
authors.lastname: Bartorelli