title: The serum level of interleukin-6 in patients with intellectual disability and refractory epilepsy.
abstract: We aimed to study the influences of active epilepsy and intellectual disability (ID) on the serum interleukin-6 (IL-6) by determining levels in 74 patients with developmental disorder with epilepsy and 63 healthy controls. The patients showed significantly higher IL-6 levels than the controls (4.1±4.5pg/ml vs. 2.1±1.0pg/ml; p<0.001). High seizure frequency and severe intellectual disability emerged as predictors for elevated serum levels of IL-6.
authors.affiliation: Department of Neurosurgery, Tampere University Hospital, Teiskontie 35, Tampere, Finland. kai.lehtimaki@pshp.fi
authors.forename: Kai A
authors.initials: KA
authors.lastname: Lehtimäki
authors.forename: Suvi
authors.initials: S
authors.lastname: Liimatainen
authors.forename: Jukka
authors.initials: J
authors.lastname: Peltola
authors.forename: Maria
authors.initials: M
authors.lastname: Arvio
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001321:Autistic Disorder / Q000097:blood / Q000150:complications; D004314:Down Syndrome / Q000097:blood / Q000150:complications; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy / Q000209:etiology / Q000235:genetics / Q000523:psychology; D005260:Female; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007249:Inflammation; D008607:Intellectual Disability / Q000097:blood* / Q000150:complications; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012598:Sclerosis; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; C508600:IL6 protein, human; D015850:Interleukin-6