title: Hybrid modeling of xanthan gum bioproduction in batch bioreactor.
abstract: This work is focused on hybrid modeling of xanthan gum bioproduction process by Xanthomonas campestris pv. mangiferaeindicae. Experiments were carried out to evaluate the effects of stirred speed and superficial gas velocity on the kinetics of cell growth, lactose consumption and xanthan gum production in a batch bioreactor using cheese whey as substrate. A hybrid model was employed to simulate the bio-process making use of an artificial neural network (ANN) as a kinetic parameter estimator for the phenomenological model. The hybrid modeling of the process provided a satisfactory fitting quality of the experimental data, since this approach makes possible the incorporation of the effects of operational variables on model parameters. The applicability of the validated model was investigated, using the model as a process simulator to evaluate the effects of initial cell and lactose concentration in the xanthan gum production.
authors.affiliation: Department of Food Engineering, URI, Campus de Erechim, Av. Sete de Setembro, 1621, Erechim 99700-000, Brazil.
authors.forename: Giovani L
authors.initials: GL
authors.lastname: Zabot
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Mecca
authors.forename: Michele
authors.initials: M
authors.lastname: Mesomo
authors.forename: Marceli F
authors.initials: MF
authors.lastname: Silva
authors.forename: Valéria Dal
authors.initials: VD
authors.lastname: Prá
authors.forename: Débora
authors.initials: D
authors.lastname: de Oliveira
authors.forename: J Vladimir
authors.initials: JV
authors.lastname: Oliveira
authors.forename: Fernanda
authors.initials: F
authors.lastname: Castilhos
authors.forename: Helen
authors.initials: H
authors.lastname: Treichel
authors.forename: Marcio A
authors.initials: MA
authors.lastname: Mazutti
mesh_terms: D019149:Bioreactors / Q000382:microbiology*; D003198:Computer Simulation; D007700:Kinetics; D007785:Lactose / Q000378:metabolism; D008894:Milk Proteins / Q000378:metabolism*; D008954:Models, Biological; D016571:Neural Networks, Computer; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis*; D016959:Xanthomonas campestris / Q000254:growth & development / Q000378:metabolism*
chemical_list: D008894:Milk Proteins; D011135:Polysaccharides, Bacterial; D007785:Lactose; C002563:xanthan gum