title: Liver transplantation for symptomatic centrohepatic biliary cystadenoma.
abstract: Biliary cystadenoma is a rare benign cystic tumor of the liver. The mainstay of treatment is complete resection, either by enucleation or by formal hepatectomy, since incomplete removal entails not only constant recurrence but also the risk of malignant transformation to cystadenocarcinoma. A case of symptomatic centrohepatic biliary cystadenoma involving the main vasculobiliary structures of the liver is reported. After an unsuccessful attempt at resection resulting in an intrahepatic biliary injury, relief of jaundice and radical excision were achieved by total hepatectomy and liver transplantation. The patient is now alive and well 4 years after transplant, disease-free, with normal liver and renal function while receiving everolimus monotherapy. This is the first report of liver transplantation performed for the treatment of this tumor. With the case on the background, diagnostic aspects and available therapeutic strategies for biliary cystadenoma are reviewed and discussed.
authors.affiliation: General Surgery 8 and Liver Transplantation Center, University of Turin, AOU San Giovanni Battista, Corso Bramante 88, 10126 Turin, Italy. rromagnoli3@molinette.piemonte.it
authors.forename: Renato
authors.initials: R
authors.lastname: Romagnoli
authors.forename: Damiano
authors.initials: D
authors.lastname: Patrono
authors.forename: Gianluca
authors.initials: G
authors.lastname: Paraluppi
authors.forename: Ezio
authors.initials: E
authors.lastname: David
authors.forename: Francesco
authors.initials: F
authors.lastname: Tandoi
authors.forename: Paolo
authors.initials: P
authors.lastname: Strignano
authors.forename: Francesco
authors.initials: F
authors.lastname: Lupo
authors.forename: Mauro
authors.initials: M
authors.lastname: Salizzoni
mesh_terms: D003537:Cystadenoma / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000601:surgery*; D016031:Liver Transplantation; D008875:Middle Aged