title: [Diagnostic work-up in Whipple's disease with cerebral involvement].
abstract: The diagnostic work-up in the case of a suspected cerebral involvement of Whipple's disease involves neuroimaging and analysis of cerebrospinal fluid (CSF) including polymerase chain reaction (PCR) assays for Tropheryma whipplei. As neurological findings may be complex and unspecific, extracerebral symptoms often lead to the suspicion of Whipple's disease. We report the cases of two patients in whom the suspected diagnosis of Whipple's disease could not be proved either by endoscopy or by the analysis of CSF. Only by means of a cerebral biopsy was the diagnosis assumed and specific therapy was initiated.
authors.affiliation: Klinik und Poliklinik für Neurologie, Uniklinik Köln. anna.diels@uk-koeln.de
authors.forename: A
authors.initials: A
authors.lastname: Diels
authors.forename: S
authors.initials: S
authors.lastname: Pfeifenbring
authors.forename: C
authors.initials: C
authors.lastname: Eggers
authors.forename: N
authors.initials: N
authors.lastname: Galldiks
authors.forename: G R
authors.initials: GR
authors.lastname: Fink
authors.forename: L
authors.initials: L
authors.lastname: Burghaus
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D001921:Brain / Q000382:microbiology / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D019411:Clinical Laboratory Techniques; D003071:Cognition / Q000502:physiology; D006801:Humans; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction; D054851:Tropheryma / Q000235:genetics; D008061:Whipple Disease / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents