title: The Patient Care Monitor-Neutropenia Index: development, reliability, and validity of a measure for chemotherapy-induced neutropenia.
abstract: OBJECTIVE
  To provide an initial evaluation of the psychometric properties of the Patient Care Monitor 1.0 Revised-Neutropenia Index (PCM-N), a symptom-based assessment tool designed to measure health-related quality-of-life (HRQOL) changes associated with chemotherapy-induced neutropenia.
  
  
  METHODS
  Known-groups methodology and self-report instrument validation.
  
  
  METHODS
  A large community oncology practice in Memphis, TN.
  
  
  METHODS
  424 patients with cancer in four samples.
  
  
  METHODS
  All patients in the first three samples were assessed at baseline of chemotherapy administration and at a point analogous to midcycle. The fourth sample underwent a cross-sectional evaluation of the ability of the PCM-N to distinguish patients with febrile neutropenia, severe afebrile neutropenia, and no neutropenia.
  
  
  METHODS
  PCM-N score, grade of neutropenia, and febrile status.
  
  
  RESULTS
  Internal consistency reliability and factor analysis supported the single additive scale structure of the 13 items of the PCM-N. The PCM-N demonstrated good known-groups validity and was able to distinguish patients with grades 3-4 neutropenia from those with grades 0-2. The tool also was able to distinguish patients with febrile neutropenia, severe afebrile neutropenia, and no neutropenia. Receiver operating characteristic analyses provided a psychometrically based threshold score.
  
  
  CONCLUSIONS
  The PCM-N is a reliable and valid instrument sensitive to changes in HRQOL associated with moderate-to-severe chemotherapy-induced neutropenia.
  
  
  CONCLUSIONS
  Nurses can use the PCM-N as a rapid and cost-effective tool for monitoring symptoms of neutropenia in patients with cancer.
authors.affiliation: Department of Psychology, University of Memphis, Tennessee, USA. jolsen@memphis.edu
authors.forename: James P
authors.initials: JP
authors.lastname: Olsen
authors.forename: Scott
authors.initials: S
authors.lastname: Baldwin
authors.forename: Arthur C
authors.initials: AC
authors.lastname: Houts
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016903:Drug Monitoring / Q000379:methods / Q000451:nursing / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000451:nursing*; D009503:Neutropenia / Q000139:chemically induced* / Q000451:nursing; D009859:Oncology Nursing / Q000379:methods*; D011594:Psychometrics / Q000592:standards; D011788:Quality of Life; D012372:ROC Curve; D015203:Reproducibility of Results
chemical_list: D000970:Antineoplastic Agents