title: Expression of Mmachc and Mmadhc during mouse organogenesis.
abstract: To examine whether Mmachc and Mmadhc, two genes involved in vitamin B(12) (cobalamin) metabolism, show tissue-specific expression during mouse embryogenesis, we determined their sites of expression at 11.5days post conception by in situ hybridization. There was ubiquitous expression of Mmadhc, but tissue and cell type-specific expression of Mmachc in the developing lung, heart, cardiovascular and nervous system. This suggests that during organogenesis Mmachc and Mmadhc may interact in only a subset of cells.
authors.affiliation: Department of Human Genetics, McGill University, Montreal, Quebec, Canada H3A 1B1.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Pupavac
authors.forename: Maira A Moreno
authors.initials: MA
authors.lastname: Garcia
authors.forename: David S
authors.initials: DS
authors.lastname: Rosenblatt
authors.forename: Loydie A
authors.initials: LA
authors.lastname: Jerome-Majewska
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D004622:Embryo, Mammalian / Q000378:metabolism; D017403:In Situ Hybridization; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D008815:Mice, Inbred Strains; D009928:Organ Specificity; D038081:Organogenesis / Q000235:genetics; D010088:Oxidoreductases; D014805:Vitamin B 12 / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C570225:Mmadhc protein, mouse; C570224:Mmachc protein, mouse; D010088:Oxidoreductases; D014805:Vitamin B 12