title: Vitamin-C, steroid and environmental carcinogenesis (review).
abstract: An attempt was made to investigate the relation between oxidative metabolism of neoplastic tissues and carcinogenesis from the point of view of the vitaminology/endocrinology fusion science. Our discussion was developed on the basis of maximum information available in- and outside our laboratory. We present 3 suggestions to throw new light on the phenomenon of eternal enigma - carcinogenesis. They are given as follows: i) the emergence of the oxidant criminal theory motivated us to refresh our old memory surrounding the metabolic characteristics of cancer cells with increased aerobic glycolysis. Evidence was presented to suggest that a neoplastic cell in its behavior can be classified as a facultative anaerobe, whereas a non-neoplastic cell belongs to the family of obligate aerobes. Information is also available to indicate that both glucocorticoid and vitamin C are working together to maintain concerted relationship between mitochondria and cytoplasm. On the basis of the information in paleontology, we propose to assume the metabolic characteristics of a neoplastic cell as an example of failed symbiosis between oxidant-intoxicated host cell (an anaerobe) and rebelling mitochondria (aerobes). ii) In view of the complexity of relation between the ever-changing environment and the humans as regards the cancer risk variations in time and space, we propose to assume the presence of a signal translation system as the intermediator between the outer environment and the target tissue. The steroid generating system, of which the implication to carcinogenesis is suggested in both human and non-human systems, may take over that role maintaining a cross talk with the hypothalamus-pituitary complex. One finds a good model of carcinogenesis in polymorphism of insects in which tranposon may well play important role in the induction of genetic transformation. iii) We should make further effort to explore the usefulness of vitamin C in cancer prevention. Worth consideration in this respect is our clinical experience that autoimmune disease and allergy are controlled through vitamin C infusion treatment by way of ACTH-linked stimulation of adrenocortical function - a modification of the hormonal milieu by use of vitamin C.
authors.affiliation: NATL CANC CTR,RES INST,DIV BIOPHYS,TOKYO 104,JAPAN.
authors.forename: M
authors.initials: M
authors.lastname: Kodama
authors.forename: T
authors.initials: T
authors.lastname: Kodama