title: Y chromosome--a tool in infertility studies of Latvian population.
abstract: Human Y chromosome is used as a tool in male infertility and population genetic studies. The aims of this research were to analyse the prevalence of Y chromosome microdeletions among infertile Latvian men, and to identify possible lineages of Y chromosome that may be at increased risk of developing infertility. A study encompassed 105 infertile men with different spermatogenic disturbances. Deletions on Y chromosome were detected in 5 out of 105 (approximately 5%) cases analysed in this study. Three of them carried deletion in AZFc region and two individuals had AZFa + b + c deletion. Study of Y chromosome haplogroups showed that N3a1 and R1a1 lineages were found less frequently in the infertile male group compared to ethnic Latvian group, however K* cluster was predominantly found in infertile male Y chromosomes.
  
  
  CONCLUSIONS
  1) Our study advocates running Y chromosome microdeletion analyses only in cases of severe form of infertility; 2) Y chromosome haplogroup analysis showed statistically significant tendencies that some haplogroups are more common in ethnic male group, but others are more common in infertile males.
authors.affiliation: Riga Stradins University, Department of Medical Biology and Genetics, Riga LV-1007, Latvia. agrita.puzuka@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Puzuka
authors.forename: N
authors.initials: N
authors.lastname: Pronina
authors.forename: I
authors.initials: I
authors.lastname: Grinfelde
authors.forename: Ju
authors.initials: J
authors.lastname: Erenpreiss
authors.forename: V
authors.initials: V
authors.lastname: Lejins
authors.forename: Ja
authors.initials: J
authors.lastname: Bars
authors.forename: L
authors.initials: L
authors.lastname: Pliss
authors.forename: I
authors.initials: I
authors.lastname: Pelnena
authors.forename: V
authors.initials: V
authors.lastname: Baumanis
authors.forename: A
authors.initials: A
authors.lastname: Krumina
mesh_terms: D000328:Adult; D041322:Chromosomes, Human, Y / Q000235:genetics*; D056426:Genetic Loci; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007844:Latvia; D008297:Male; D008875:Middle Aged; D029589:Seminal Plasma Proteins / Q000235:genetics; D017384:Sequence Deletion; D055815:Young Adult
chemical_list: D029589:Seminal Plasma Proteins