title: The effects of shear flow on protein structure and function.
abstract: Protein molecules are subjected to potentially denaturing fluid shear forces during processing and in circulation in the body. These complex molecules, involved in numerous biological functions and reactions, can be significantly impaired by molecular damage. There have been many studies on the effects of hydrodynamic shear forces on protein structure and function. These studies are reviewed and the implications to bioprocessing and pathophysiology of certain diseases are discussed.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, VIC 3010, Australia.
authors.forename: Innocent B
authors.initials: IB
authors.lastname: Bekard
authors.forename: Peter
authors.initials: P
authors.lastname: Asimakis
authors.forename: Joseph
authors.initials: J
authors.lastname: Bertolini
authors.forename: Dave E
authors.initials: DE
authors.lastname: Dunstan
mesh_terms: D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D012996:Solutions
chemical_list: D011506:Proteins; D012996:Solutions