title: Pregnancy in a woman with premature ovarian insufficiency undergoing intracytoplasmic sperm injection after pretreatment with estrogens followed by therapy with estrogens associated with ovarian stimulation with gonadotropins: remarks about oocyte and embryo quality.
abstract: OBJECTIVE
  The aim of this study was to achieve pregnancy in a woman with premature ovarian insufficiency (POI) by means of estrogen pretreatment, a combination of estrogen therapy and gonadotropin ovarian stimulation, and intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  A 34-year-old woman with POI who failed to achieve follicular growth in two previous ovarian stimulation protocols using high doses of gonadotropins alone underwent an ICSI trial after estrogen pretreatment (ethinyl estradiol 0.05 mg three times a day for 10 d) followed by estrogens (at the same dose) and recombinant β-follicle-stimulating hormone (250 IU/d for 12 d).
  
  
  RESULTS
  Delivery of a healthy female baby was achieved.
  
  
  CONCLUSIONS
  Stimulation with gonadotropins plus estrogens after pretreatment with estrogen can be considered a useful intervention in women with POI trying to conceive.
authors.affiliation: Department of Obstetrics and Gynecology, University of Bari, Policlinico of Bari, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Tartagni
authors.forename: Gianluca Raffaello
authors.initials: GR
authors.lastname: Damiani
authors.forename: Edoardo
authors.initials: E
authors.lastname: Di Naro
authors.forename: Paolo
authors.initials: P
authors.lastname: Persiani
authors.forename: Claudio
authors.initials: C
authors.lastname: Crescini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Loverro
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000188:drug therapy; D011247:Pregnancy; D011292:Premedication; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D004967:Estrogens; D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone