title: Elevated body mass index is associated with lower serum anti-mullerian hormone levels in infertile women with diminished ovarian reserve but not with normal ovarian reserve.
abstract: OBJECTIVE
  To investigate the association between elevated body mass index (BMI) and ovarian reserve.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Academic institutions.
  
  
  METHODS
  Two hundred ninety women with infertility. Diminished ovarian reserve (DOR) was defined as day 3 FSH>10 IU/L.
  
  
  METHODS
  None.
  
  
  METHODS
  Random serum antimullerian hormone (AMH) levels and number of oocytes retrieved during assisted reproductive technology cycle.
  
  
  RESULTS
  Increasing BMI was associated with lower random serum AMH levels in infertile women with DOR but not in women with normal ovarian reserve (NOR). Among women with DOR, mean random serum AMH levels were 33% lower in overweight and obese women compared with women with normal weight. The same association was not true for women with NOR. Out of 290 women evaluated for infertility, 109 women underwent a controlled ovarian hyperstimulation (COH)-IVF cycle. Women with elevated BMI and DOR had lower number of oocytes retrieved compared with women with normal BMI and DOR (6.4±4.3 vs. 9.4±6), an association that was not observed among women with NOR.
  
  
  CONCLUSIONS
  Overweight and obese women with DOR as defined by high day 3 serum FSH levels have lower serum AMH levels and number of oocytes retrieved compared with nonobese women with DOR.
authors.affiliation: Montefiore Institute for Reproductive Medicine and Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA. erbuyuk@yahoo.com
authors.forename: Erkan
authors.initials: E
authors.lastname: Buyuk
authors.forename: David B
authors.initials: DB
authors.lastname: Seifer
authors.forename: Edward
authors.initials: E
authors.lastname: Illions
authors.forename: Richard V
authors.initials: RV
authors.lastname: Grazi
authors.forename: Harry
authors.initials: H
authors.lastname: Lieman
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D016014:Linear Models; D009518:New York; D054315:Oocyte Retrieval; D050177:Overweight / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D010060:Ovulation; D010062:Ovulation Induction; D027724:Reproductive Techniques, Assisted; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; D054304:Anti-Mullerian Hormone