title: Current opinion on use of luteinizing hormone supplementation in assisted reproduction therapy: an Asian perspective.
abstract: LH and FSH have complementary functions in ensuring optimal oocyte maturation and ovulation. In women undergoing assisted reproduction technology protocols with gonadotrophin-releasing hormone analogues, LH and FSH concentrations are reduced. While FSH use in assisted reproduction technology is well established, there is no published consensus on the need for exogenous LH in Asian patients. Having reviewed the concept of the LH therapeutic window and differences between recombinant human LH (r-HLH) and human menopausal gonadotrophin, a consensus was reached on which patient subgroups may benefit from LH supplementation. Adjuvant r-HLH gives clinicians precise control over the dose of LH bioactivity administered to target the therapeutic window. The use of r-HLH is recommended in women with poor response in a previous cycle or suboptimal follicular progression in a current cycle by day 6-8 of stimulation. r-HLH should also be considered in women at risk of suboptimal response, specifically age > 35 years. Other risk markers that suggest the need for LH supplementation, which include baseline/day-6 serum LH and anti-Müllerian hormone concentrations, antral follicle count and LH polymorphisms require further research and verification. For measurement of LH response adequacy, the monitoring of follicular progression, oestradiol concentrations and endometrial thickness is recommended.
authors.affiliation: Department of Obstetrics and Gynaecology, National University Hospital, Singapore. peng_cheang_wong@nuhs.edu.sg
authors.forename: Peng Cheang
authors.initials: PC
authors.lastname: Wong
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
authors.forename: Clement
authors.initials: C
authors.lastname: Ho
authors.forename: Gottumukkala A
authors.initials: GA
authors.lastname: Ramaraju
authors.forename: Budi
authors.initials: B
authors.lastname: Wiweko
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takehara
authors.forename: Prashant V
authors.initials: PV
authors.lastname: Nadkarni
authors.forename: Li-Chang
authors.initials: LC
authors.lastname: Cheng
authors.forename: Hsin-Fu
authors.initials: HF
authors.lastname: Chen
authors.forename: Somchai
authors.initials: S
authors.lastname: Suwajanakorn
authors.forename: Thi Ngoc Lan
authors.initials: TN
authors.lastname: Vuong
mesh_terms: D000328:Adult; D000367:Age Factors; D006063:Chorionic Gonadotropin / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone; D006207:Half-Life; D006801:Humans; D007986:Luteinizing Hormone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted / Q000639:trends
chemical_list: D006063:Chorionic Gonadotropin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone