title: Lack of association between paraoxonase 1 Q192R polymorphism and multiple sclerosis in relapse phase: A case-control study.
abstract: OBJECTIVE
  The aim of this study was to estimate the serum activity of paraoxonase 1(PON1) and assess the distribution of PON1 polymorphisms in MS patients in the relapse phase.
  
  
  METHODS
  PON1 and arylesterase (ARE) serum activities were measured in two equal groups (each group 63 cases) of relapsing-remitting MS patients and healthy individuals.
  
  
  RESULTS
  Mean values for serum PON1 and ARE activities were 90.3±63.4 and 182.1±128.7IU/L for patients and 99.9±73.3 and 190.8±150.3IU/L for controls. Those values were not statistically significant (p=0.242 and p=0.378), respectively. Comparing genotype distributions and allele frequencies in both groups for PON1 Q192R and PON L55M polymorphisms did not show any statistical difference.
  
  
  CONCLUSIONS
  In a selected group of MS patients in relapsing phase no statistically significant difference in PON1 and ARE activities was detected but the mean values for the serum enzyme activities were lower in MS patients.
authors.affiliation: Neurology Department, Zahedan University of Medical Sciences, Zahedan, Iran. amoghtaderi@gmail.com
authors.forename: Ali
authors.initials: A
authors.lastname: Moghtaderi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.forename: Naser
authors.initials: N
authors.lastname: Sharafaddinzadeh
authors.forename: Soroosh
authors.initials: S
authors.lastname: Dabiri
authors.forename: Abdolkarim
authors.initials: A
authors.lastname: Moazeni-Roodi
authors.forename: Noorollah
authors.initials: N
authors.lastname: Ramroodi
authors.forename: Moloud
authors.initials: M
authors.lastname: Zolfaghari
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D003710:Demography; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human