title: Different associations of periventricular and deep white matter lesions with cognition, neuropsychiatric symptoms, and daily activities in dementia.
abstract: We investigated the associations of periventricular white matter hyperintensities (PWMHs) and deep white matter hyperintensities (DWMHs) with cognition, activities of daily living (ADLs), and neuropsychiatric symptoms in dementia. This was a hospital-based MRI300 study. We recruited patients newly diagnosed with mild-to-moderate dementia caused either by Alzheimer's disease or subcortical ischemic vascular dementia from 13 dementia clinics at university or general hospitals in South Korea. We enrolled 289 patients aged over 50 from August 2007 to March 2008. We compared cognition, ADLs, and neuropsychiatric symptoms among 3 groups according to the severities of PWMHs and DWMHs, respectively, by adjusting for age, vascular risk factors, and level of other WMHs. A higher severity of PWMHs was related to lower cognitive function and severer neuropsychiatric symptoms, whereas basic ADLs were associated with DWMH. Both PWMHs and DWMHs exhibited different associations with cognition, neuropsychiatric symptoms, and daily activities.
authors.affiliation: Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea.
authors.lastname: Kee Hyung Park
authors.forename: Jun-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
authors.forename: Seong Yoon
authors.initials: SY
authors.lastname: Kim
authors.forename: Hae-Kwan
authors.initials: HK
authors.lastname: Cheong
authors.forename: So Young
authors.initials: SY
authors.lastname: Moon
authors.forename: Yong S
authors.initials: YS
authors.lastname: Shim
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Park
authors.forename: Bon D
authors.initials: BD
authors.lastname: Ku
authors.forename: Seong Hye
authors.initials: SH
authors.lastname: Choi
authors.forename: Hwan
authors.initials: H
authors.lastname: Joo
authors.forename: Joong Sun
authors.initials: JS
authors.lastname: Lee
authors.forename: Seok Min
authors.initials: SM
authors.lastname: Go
authors.forename: Sook Hui
authors.initials: SH
authors.lastname: Kim
authors.forename: SangYun
authors.initials: S
authors.lastname: Kim
authors.forename: Kyung Ryeol
authors.initials: KR
authors.lastname: Cha
authors.forename: Juwon
authors.initials: J
authors.lastname: Lee
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D003704:Dementia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology* / Q000502:physiology; D009483:Neuropsychological Tests; D012307:Risk Factors