title: ACR Appropriateness Criteria® on Hodgkin's lymphoma-unfavorable clinical stage I and II.
abstract: Combined-modality therapy, consisting of chemotherapy followed by radiation therapy (RT), represents the standard of care for most patients with unfavorable-prognosis early-stage Hodgkin's lymphoma. The most widely accepted chemotherapy regimen is ABVD (Adriamycin, bleomycin, vinblastine, and dacarbazine); however, recent trials have evaluated other regimens such as BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) and Stanford V. After chemotherapy, the standard radiation field is involved-field RT, although there is increasing interest now in involved-node RT. The authors review recent trials on chemotherapy and RT for unfavorable-prognosis early-stage Hodgkin's lymphoma. This article presents illustrative clinical cases, with treatment recommendations from an expert panel of radiation oncologists and medical oncologists.
authors.affiliation: The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. prajdas@mdanderson.org
authors.forename: Prajnan
authors.initials: P
authors.lastname: Das
authors.forename: Andrea
authors.initials: A
authors.lastname: Ng
authors.forename: Louis S
authors.initials: LS
authors.lastname: Constine
authors.forename: Ranjana
authors.initials: R
authors.lastname: Advani
authors.forename: Christopher
authors.initials: C
authors.lastname: Flowers
authors.forename: Jonathan
authors.initials: J
authors.lastname: Friedberg
authors.forename: David C
authors.initials: DC
authors.lastname: Hodgson
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Schwartz
authors.forename: Richard B
authors.initials: RB
authors.lastname: Wilder
authors.forename: Lynn D
authors.initials: LD
authors.lastname: Wilson
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Yunes
mesh_terms: D006689:Hodgkin Disease / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008495:Medical Oncology / Q000592:standards*; D009367:Neoplasm Staging; D017410:Practice Guidelines as Topic; D011871:Radiology / Q000592:standards*; D012955:Societies, Medical; D014481:United States