title: A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies.
abstract: Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) = 1.06-1.77) in one study with 961 cases and 922 controls, we observed no association in the remaining three studies including 1452 cases and 1954 controls (OR=0.83, 95% CI= 0.66-1.04). Therefore, there appears to be no strong evidence of association between GALNT2 SNP rs2271077 and ovarian cancer risk.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Terry
authors.forename: Allison F
authors.initials: AF
authors.lastname: Vitonis
authors.forename: Dena
authors.initials: D
authors.lastname: Hernandez
authors.forename: Galina
authors.initials: G
authors.lastname: Lurie
authors.forename: Honglin
authors.initials: H
authors.lastname: Song
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Ramus
authors.forename: Linda
authors.initials: L
authors.lastname: Titus-Ernstoff
authors.forename: Michael E
authors.initials: ME
authors.lastname: Carney
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Gentry-Maharaj
authors.forename: Usha
authors.initials: U
authors.lastname: Menon
authors.forename: Simon A
authors.initials: SA
authors.lastname: Gayther
authors.forename: Paul D
authors.initials: PD
authors.lastname: Pharaoh
authors.forename: Marc T
authors.initials: MT
authors.lastname: Goodman
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Cramer
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Birrer