title: Palladium-catalyzed oxidative cyclization of 3-phenoxyacrylates: an approach to construct substituted benzofurans from phenols.
abstract: In this paper, a novel and applicable synthesis of benzofurans from commercially available phenols and propiolate through the direct oxidative cyclization has been developed. In the presence of Pd(OAc)(2)/PPh(3) and CF(3)CO(2)Ag, (E)-type 3-phenoxyacrylates underwent reaction smoothly to generate the corresponding benzofurans in good yields in benzene at 110 °C under the air pressure. In addition, this transformation of phenols into benzofurans can also be carried out in one pot. The process was simple and efficient. A tentative mechanism of palladium-catalyzed oxidative cyclization of 3-phenoxyacrylates was proposed.
authors.affiliation: Department of Chemistry, Huaibei Normal University, Huaibei, Anhui, P R China.
authors.forename: Chengliang
authors.initials: C
authors.lastname: Li
authors.forename: Yicheng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Pinhua
authors.initials: P
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*
chemical_list: D000179:Acrylates; D001572:Benzofurans; D010636:Phenols; D010165:Palladium; C036658:acrylic acid; C105430:benzofuran