title: Cerebral metabolic and vasopressin and oxytocin responses during osmotic stimulation in conscious rats.
abstract: Intravenous infusion of hypertonic saline increased plasma [Na (+) ] and osmolality and induced a short-latency drinking response. These changes were associated with increased glucose utilization in the supraoptic and paraventricular nuclei and neural lobe, and decreases in the medial septum and nucleus ambiguus. The increases in glucose utilization were more accentuated in the supraoptic nuclei than in paraventricular nuclei, indicating that they are more sensitive to osmotic stimulation than the paraventricular nuclei. In association with enhanced activity in the hypothalamo-neurohypophysial system, plasma vasopressin and oxytocin concentrations increased, with a preferential increase of oxytocin over vasopressin. The hormonal contents in the neural lobe were not depleted by the osmotic stimulus despite the large increases of their concentrations in the plasma.
authors.affiliation: Division of Neurosurgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA. Department of Pharmacology, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania 17033, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kadekaro
authors.forename: J Y
authors.initials: JY
authors.lastname: Summy-Long
authors.forename: J S
authors.initials: JS
authors.lastname: Harris
authors.forename: M L
authors.initials: ML
authors.lastname: Terrell
authors.forename: S
authors.initials: S
authors.lastname: Freeman
authors.forename: H M
authors.initials: HM
authors.lastname: Eisenberg