title: Gamma knife radiosurgery for central neurocytoma: retrospective analysis of fourteen cases with a median follow-up period of sixty-five months.
abstract: OBJECTIVE
  Central neurocytoma (CN) is considered to be a benign neuronal tumor with possible atypical behavior. Microsurgery, radiation therapy (RT) and radiosurgery all have been used in treating this rare disease during the past decade. In this study, the authors present the experience with gamma knife radiosurgery (GKRS) on 14 patients with CN during a median follow-up period of 65 months and document the safety and efficacy of GKRS in the treatment of CN.
  
  
  METHODS
  Between November 1997 and December 2009, 14 patients pathologically diagnosed with CN were treated with GKRS. Follow-up magnetic resonance imaging (MRI) was performed at 6-month intervals. Tumor volume and adverse radiation effects (ARE) were documented to evaluate tumor response to GKRS. The Karnofsky Performance Scale (KPS) and neurological status were used to assess clinical outcome. The mean radiation dose prescribed to the tumor margin was 12.1 Gy (ranging from 11 to 13 Gy). The mean tumor volume was 19.6 ml (ranging from 3.5 to 48.9 ml). The mean follow-up period was 70 months (ranging from 30 to 140 months), and the median follow-up period was 65 months.
  
  
  RESULTS
  Tumor shrinkage was found in all patients at the final MRI follow-up. The mean volume reduction was 69% (ranging from 47 to 87%). No tumor progression, ARE or radiation-related toxicity developed in any of the cases. The KPS scores of all patients were the same or had increased, and the neurological functions were all stable without deterioration at the final follow-up.
  
  
  CONCLUSIONS
  In our observations, GKRS was found to be an effective and safe alternative as adjuvant therapy for pathology-confirmed CN. The tumor volume and functional outcome can be controlled with a favorable result in long-term observation. Compared with RT and microsurgery, GKRS plays an important role in the treatment of CN as a minimally invasive technique with low morbidity. Regular long-term MRI follow-up should be mandatory to document the tumor response and possible recurrence. Multicenter consortia should be considered for further investigation and evaluation of GKRS for such a rare tumor.
authors.affiliation: Department of Neurosurgery, Taipei City Hospital, Taiwan, Republic of China.
authors.forename: Meng-Chao
authors.initials: MC
authors.lastname: Chen
authors.forename: David Hung-Chi
authors.initials: DH
authors.lastname: Pan
authors.forename: Wen-Yuh
authors.initials: WY
authors.lastname: Chung
authors.forename: Kang-Du
authors.initials: KD
authors.lastname: Liu
authors.forename: Yu-Shu
authors.initials: YS
authors.lastname: Yen
authors.forename: Ming-Teh
authors.initials: MT
authors.lastname: Chen
authors.forename: Tai-Tong
authors.initials: TT
authors.lastname: Wong
authors.forename: Yang-Hsin
authors.initials: YH
authors.lastname: Shih
authors.forename: Hsiu-Mei
authors.initials: HM
authors.lastname: Wu
authors.forename: Wan-Yuo
authors.initials: WY
authors.lastname: Guo
authors.forename: Cheng-Ying
authors.initials: CY
authors.lastname: Shiau
authors.forename: Ling-Wei
authors.initials: LW
authors.lastname: Wang
authors.forename: Chii-Wann
authors.initials: CW
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000601:surgery*; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D018306:Neurocytoma / Q000601:surgery*; D016634:Radiosurgery / Q000295:instrumentation*; D012189:Retrospective Studies; D016896:Treatment Outcome