title: Vitamin D deficiency and insulin resistance in obese African-American adolescents.
abstract: OBJECTIVE
  The study aim determined if low 25-hydroxy vitamin D levels correlated with low levels of adiponectin and insulin resistance in African American adolescents with body mass index > or = 85th %.
  
  
  METHODS
  Fasting blood levels of adiponectin, 25-hydroxy vitamin D, insulin, glucose, lipid, leptin and glycosylated hemoglobin were measured in a total of 34 (19 study and 15 control) African American adolescents between the ages of 10 and 20 years. Nutritional vitamin D intake and body composition measurements were assessed. Insulin resistance was calculated using the homeostasis model assessment.
  
  
  RESULTS
  Adiponectin, fasting insulin, glucose, leptin, triglycerides, HDL, and 25-hydroxy vitamin D levels all reached statistical significance in the group with body mass index > or = 85th percentile when compared to the control population. There was no difference in vitamin D intake between the two groups.
  
  
  CONCLUSIONS
  Low vitamin D levels correlated with low adiponectin levels and obesity and insulin resistance.
authors.affiliation: Division of Endocrinology, Howard University, Washington, DC, USA.
authors.forename: Gail
authors.initials: G
authors.lastname: Nunlee-Bland
authors.forename: Kanwal
authors.initials: K
authors.lastname: Gambhir
authors.forename: Cynthia
authors.initials: C
authors.lastname: Abrams
authors.forename: Mustapha
authors.initials: M
authors.lastname: Abdul
authors.forename: Marjan
authors.initials: M
authors.lastname: Vahedi
authors.forename: Wolali
authors.initials: W
authors.lastname: Odonkor
mesh_terms: D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D056865:Ideal Body Weight / Q000502:physiology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood; D008297:Male; D009752:Nutritional Status / Q000502:physiology; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000453:epidemiology*; D050177:Overweight / Q000097:blood / Q000150:complications / Q000453:epidemiology; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications* / Q000453:epidemiology*; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D007328:Insulin; D020738:Leptin; D014807:Vitamin D; C104450:25-hydroxyvitamin D