title: Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons.
abstract: The neurons in the brain produce sequential spikes as the digital codes whose various patterns manage well-organized cognitions and behaviors. A source for the physiologically integrated synaptic signals to initiate digital spikes remains unknown, which we studied at pyramidal neurons of cortical slices. In dual recordings from the soma vs. axon, the signals recorded in vivo induce somatic spikes with higher capacity, which is associated with lower somatic thresholds and shorter refractory periods mediated by voltage-gated sodium channels. The introduction of these parameters from the soma and axon into NEURON model simulates sequential spikes being somatic in origin. Physiological signals integrated from synaptic inputs primarily trigger the soma to encode neuronal digital spikes.
authors.affiliation: State Key Lab for Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Rongjing
authors.initials: R
authors.lastname: Ge
authors.forename: Hao
authors.initials: H
authors.lastname: Qian
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology; D003198:Computer Simulation; D051379:Mice; D017966:Pyramidal Cells / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012032:Refractory Period, Electrophysiological; D015398:Signal Transduction; D015222:Sodium Channels / Q000378:metabolism; D013569:Synapses / Q000502:physiology*; D013997:Time Factors
chemical_list: D015222:Sodium Channels