title: Cytoplasmic polyadenylation and translational control.
abstract: Cytoplasmic polyadenylation is the process by which dormant, translationally inactive mRNAs become activated via the elongation of their poly(A) tails in the cytoplasm. This process is regulated by the conserved cytoplasmic polyadenylation element binding (CPEB) protein family. Recent studies have advanced our understanding of the molecular code that dictates the timing of CPEB-mediated poly(A) tail elongation and the extent of translational activation. In addition, evidence for CPEB-independent mechanisms has accumulated, and the breath of biological circumstances in which cytoplasmic polyadenylation plays a role has expanded. These observations underscore the versatility of CPEB as a translational regulator, and highlight the diversity of cytoplasmic polyadenylation mechanisms.
authors.affiliation: Gene Regulation Programme, Centre for Genomic Regulation (CRG) and UPF, Dr Aiguader 88, 08003-Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Villalba
authors.forename: Olga
authors.initials: O
authors.lastname: Coll
authors.forename: Fátima
authors.initials: F
authors.lastname: Gebauer
mesh_terms: D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D026723:Polyadenylation / Q000235:genetics*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: D012333:RNA, Messenger