title: Synthesis, nucleic acid binding and cytotoxicity of polyethyleneimine-copper(II) complexes containing 1,10-phenanthroline and l-valine.
abstract: The polymer-copper(II) complex samples, [Cu(phen)(l-Val) BPEI]Cl·H(2)O, with varying degrees of coordination in the polymer chain, were prepared and characterized by elemental analysis and spectroscopic methods. The binding of these complex samples with both DNA and RNA has been investigated. The experimental results indicate that the polyethyleneimine-copper(II) complex samples bind with DNA and RNA mostly through surface binding; but hydrogen bonding and van der Waals interactions are also present. Evaluation of cytotoxic activity of a sample of polymer-copper(II) complex with higher degree of coordination against different cancer cell lines proved that the complex exhibited cytotoxic specificity and significant cancer cell inhibition rate.
authors.affiliation: School of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
authors.forename: Jagadeesan
authors.initials: J
authors.lastname: Lakshmipraba
authors.forename: Sankaralingam
authors.initials: S
authors.lastname: Arunachalam
authors.forename: Devadas Avinash
authors.initials: DA
authors.lastname: Gandi
authors.forename: Thyagarajan
authors.initials: T
authors.lastname: Thirunalasundari
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001665:Binding Sites; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D006801:Humans; D006860:Hydrogen Bonding; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects; D015394:Molecular Structure; D010618:Phenanthrolines / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D012343:RNA, Transfer / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000737:chemistry; D013329:Structure-Activity Relationship; D014633:Valine / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D010618:Phenanthrolines; D003300:Copper; D011094:Polyethyleneimine; D004247:DNA; D012343:RNA, Transfer; C427203:calf thymus DNA; D014633:Valine; C025205:1,10-phenanthroline