title: Opportunistic invasive fungal pathogen Macrophomina phaseolina prognosis from immunocompromised humans to potential mitogenic RBL with an exceptional and novel antitumor and cytotoxic effect.
abstract: With the ever-increasing risk for fungal infections, one can no longer ignore fungi. It is imperative that clinical manifestations "presume fungus" with their epidemiologic and pathogenic features when evaluating a potentially infected patient. In the high-risk patient groups, fungi with intrinsic resistance to antifungal agents already exist, with a tendency to emerge as opportunistic pathogens. One of the smart pathogens is Macrophomina phaseolina, with the potential to disarm plant, animal, and human immunity. The response prophylaxis may vary from antifungal therapy and surgical measures to biochemical (Rhizoctonia bataticola lectin [RBL] with antitumor and cytotoxic nature) and gene therapeutics.
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, 125001 Haryana, India.
authors.forename: P
authors.initials: P
authors.lastname: Arora
authors.forename: N
authors.initials: N
authors.lastname: Dilbaghi
authors.forename: A
authors.initials: A
authors.lastname: Chaudhury
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D001203:Ascomycota / Q000145:classification / Q000187:drug effects* / Q000472:pathogenicity; D002648:Child; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D016867:Immunocompromised Host; D037102:Lectins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D008969:Molecular Sequence Data; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology / Q000628:therapy; D009894:Opportunistic Infections / Q000188:drug therapy* / Q000382:microbiology / Q000628:therapy; D011379:Prognosis; D012232:Rhizoctonia / Q000145:classification / Q000235:genetics / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D037102:Lectins; D008934:Mitogens