title: Heat shock proteins protect against ischemia and inflammation through multiple mechanisms.
abstract: After heat shock or other metabolic stress, heat shock proteins (Hsps) are expressed at high levels in all tissues and cells. The highly inducible 70 kDa heat shock protein (Hsp70) is associated with improved post-ischemic myocardial contractile recovery. Similarly, the small 27 kDa heat shock protein (Hsp27), that is abundant in muscle, is also linked with improved myocardial function after ischemic injury. Various Hsps have pro-survival functions that include chaperone, anti-apoptotic and/or anti-inflammatory activity. In this review we will summarize our understanding of myocardial protection and present evidence for protection having time dependent aspects that appear to be stimulus dependent.
authors.affiliation: Laboratory of Molecular Neurobiology, Department of Anatomy and Neurobiology, Dalhousie University, 5850 College Street, Halifax, Nova Scotia B3H 4R2, Canada.
authors.forename: Quinton
authors.initials: Q
authors.lastname: Jones
authors.forename: Tracy S
authors.initials: TS
authors.lastname: Voegeli
authors.forename: Gefeng
authors.initials: G
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: R William
authors.initials: RW
authors.lastname: Currie
mesh_terms: D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000378:metabolism / Q000502:physiology*; D018869:Heat-Shock Response / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D007328:Insulin / Q000502:physiology; D017202:Myocardial Ischemia / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D020011:Protective Agents / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D007328:Insulin; D020011:Protective Agents