title: Traumatic optic neuropathy: an evolving understanding.
abstract: OBJECTIVE
  To critically review the treatment of traumatic optic neuropathy.
  
  
  METHODS
  A perspective of clinical and basic science studies related to traumatic optic neuropathy and its treatment.
  
  
  METHODS
  Published clinical and basic science studies on traumatic optic neuropathy were critically reviewed and interpreted.
  
  
  RESULTS
  Clinical progress in the treatment of traumatic optic neuropathy is limited by small clinical studies lacking appropriate control groups. The Corticosteroid Randomization for Acute Head Trauma (CRASH) trial found an increased rate of death among patients with acute head trauma treated with high-dose corticosteroids compared to placebo-treated patients (21% vs 18%, P = .0001). Recent animal studies also suggest that high-dose corticosteroids are toxic to the injured optic nerve.
  
  
  CONCLUSIONS
  The Corticosteroid Randomization for Acute Head Trauma study is immediately relevant to the treatment of traumatic optic neuropathy as individuals with traumatic optic neuropathy often have concomitant head trauma. High-dose corticosteroids for traumatic optic neuropathy will result in a measurable loss of life in patients who also have a brain injury. Death has never been an endpoint for traumatic optic neuropathy studies. Given human and animal data suggesting that treatment is harmful and the lack of demonstrated clinical efficacy, corticosteroids should not be used to treat traumatic optic neuropathy. The benefit of optic canal decompression is also unclear. There is a need to identify traumatic optic neuropathy soon after injury to further define the natural history of this injury. This information will provide a basis for assessing potential future treatments for traumatic optic neuropathy.
authors.affiliation: Division of Orbital and Ophthalmic Plastic Surgery, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90025, USA. kenstein@ix.netcom.com
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Steinsapir
authors.forename: Robert A
authors.initials: RA
authors.lastname: Goldberg
mesh_terms: D000818:Animals; D019299:Decompression, Surgical; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D020221:Optic Nerve Injuries / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D005938:Glucocorticoids