title: The relationship between indices of iron status and selected anthropometric cardiovascular disease risk markers in an African population: the THUSA study.
abstract: There is evidence that certain indices of iron status are associated with anthropometric measures, which are used independently as markers of cardiovascular disease (CVD) risk. This study examined whether this association exists in an African population. The study was a cross-sectional comparative study that examined a total of 1 854 African participants. Ferritin was positively associated with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), percentage body fat and subscapular skinfold thickness. Serum ferritin concentration was higher in the high-WHR category than the normal-WHR category for both genders. Additionally, WC and WHR increased with increasing ferritin concentrations in both genders. Serum iron was lower in the obese than the normal-weight and pre-obese women only. In this population-based study, increased serum ferritin concentrations associated positively with increased WHR and WC, indicating that individuals or populations at risk of iron overload as defined by high serum ferritin concentrations may be at a greater risk of developing CVD.
authors.affiliation: Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. 21825890@nwu.ac.za
authors.forename: O R
authors.initials: OR
authors.lastname: Aderibigbe
authors.forename: P T
authors.initials: PT
authors.lastname: Pisa
authors.forename: R L
authors.initials: RL
authors.lastname: Mamabolo
authors.forename: H S
authors.initials: HS
authors.lastname: Kruger
authors.forename: H H
authors.initials: HH
authors.lastname: Vorster
mesh_terms: D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D005293:Ferritins / Q000097:blood*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D019189:Iron Metabolism Disorders / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D012885:Skinfold Thickness; D013019:South Africa; D014168:Transferrin / Q000032:analysis; D015854:Up-Regulation; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D014168:Transferrin; D005293:Ferritins