title: [Quantification of sclerotic renal glomeruli during the aging process in humans].
abstract: BACKGROUND
  The aim of our research was to quantify the presence of totally sclerotized glomeruli during the aging process.
  
  
  METHODS
  The study material were kidney tissue samples taken from fifty-six cadavers, their age ranging from 20 to over 70 years. They were classified in six age groups: I (20-29), II (30-39), III (40-49); IV (50-59); V (60-69) and VI (older than 70). The tissue samples were routinely histologically processed and then cut into the slices 5 mm thick, which were then stained and stereologically analyzed under the microscope with a projection screen (Reichert Visopan) with 10 x lens magnification and multipurpose test system M42 application. The analysis was carried out on 20 fields of vision per one sample. The numerical density of completely sclerotic and other glomeruli was measured, and the resulting percentages were obtained from this parameter.
  
  
  RESULTS
  Completely sclerotic glomeruli were not found in the first group. They were observed in the II aging group (5%) for the first time. Their numerical density and percentage increased during the aging process and was 18% in the IV, 25% in the V and maximally 37.5% in the VI aging group.
  
  
  CONCLUSIONS
  Finally, the above cited results pointed to the increase of completely sclerotized and the decreased presence of normal glomeruli during the aging process.
authors.affiliation: Institut za anatomiju, Medicinski fakultet, Nis.
authors.forename: Vesna
authors.initials: V
authors.lastname: Stojanović
authors.forename: Ivan
authors.initials: I
authors.lastname: Jovanović
authors.forename: Sladana
authors.initials: S
authors.lastname: Ugrenović
authors.forename: Snezana
authors.initials: S
authors.lastname: Pavlović
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D008875:Middle Aged; D012598:Sclerosis; D055815:Young Adult