title: Dispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes.
abstract: Carbon nanotubes act as a photon antenna that serves as an effective "molecular heater" around the near-infrared (NIR) region. This exothermic generation can be used as a possible heating source for hyperthermia therapy. The current study reports the dispersible and exothermic properties with NIR irradiation for single-walled carbon nanotubes (SWNTs) treated with a strong acid (acid-treated SWNTs), and the SWNTs further functionalized with double-stranded DNA (DNA-functionalized SWNTs: DNA-SWNTs). DNA-SWNTs significantly improved the dispersibility of SWNTs when compared with the acid-treated SWNTs. The binding ratio of the acid-treated SWNT and DNA was calculated to be 3.1 (DNA/SWNTs) from the phosphorous content in the DNA-SWNT. This interaction of the SWNTs and DNA would contribute to the stable dispersion of the DNA-SWNTs in a culture medium. With NIR irradiation by a halogen lamp light source, the acid-treated SWNTs and the DNA-SWNTs showed strong heat evolution in vitro (in a culture medium) and in vivo (in the subcutaneous tissue of a mouse) condition without any invasive effect on the non-SWNT area. The results of this study suggested that the functionalization with DNA was an efficient approach to improve the dispersibility of SWNTs in body fluids, and the DNA-SWNT would be a promising source for photo-induced exothermic generation.
authors.affiliation: Department of Dental Engineering, Biomaterials Section, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan. kawagum@college.fdcnet.ac.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Jun
authors.initials: J
authors.lastname: Ohno
authors.forename: Akihito
authors.initials: A
authors.lastname: Irie
authors.forename: Tadao
authors.initials: T
authors.lastname: Fukushima
authors.forename: Jun
authors.initials: J
authors.lastname: Yamazaki
authors.forename: Naotoshi
authors.initials: N
authors.lastname: Nakashima
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004247:DNA / Q000737:chemistry*; D004355:Drug Stability; D006361:Heating / Q000379:methods; D007259:Infrared Rays; D051379:Mice; D008810:Mice, Inbred C57BL; D037742:Nanotubes, Carbon / Q000737:chemistry*; D012474:Salmon; D013816:Thermodynamics; D013817:Thermography
chemical_list: D037742:Nanotubes, Carbon; D004247:DNA