title: Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors.
abstract: OBJECTIVE
  The aim of the study was to evaluate the incidence of peritoneal carcinomatosis (PC) in a prospectively recorded series of colon cancer patients from a defined cohort and to compare clinicopathological characteristics, survival, and TP53 mutation status in primary tumors from patients with and without PC.
  
  
  METHODS
  Clinical data from all colon cancer patients admitted in 1993-2006 were registered prospectively (n = 1,124). In a subset of PC patients, DNA was retrieved from tumor tissue and TP53 mutations analyzed and compared to the mutation status in a historical series.
  
  
  RESULTS
  In the prospective series 10% of female and 7% of male patients had PC (P = 0.05). The PC patients were younger than those without PC (median 4 years, P = 0.002). The incidence of PC was 10.3% and 6.2% (P = 0.03) in patients with primary tumors in the right and left colon, respectively. TP53 was mutated in 57% of the PC patients as compared to 41% in the series of patients without PC (P = 0.05).
  
  
  CONCLUSIONS
  The incidence of PC was higher in right-sided colon cancer and among women. PC patients were younger than non-PC patients, and PC was independently associated with TP53 mutation in the primary tumor.
authors.affiliation: Department of Gastrointestinal Surgery, Oslo University Hospital, Aker, Oslo, Norway. ole.h.sjo@c2i.net
authors.forename: Ole Helmer
authors.initials: OH
authors.lastname: Sjo
authors.forename: Marianne
authors.initials: M
authors.lastname: Berg
authors.forename: Marianne Arstad
authors.initials: MA
authors.lastname: Merok
authors.forename: Matthias
authors.initials: M
authors.lastname: Kolberg
authors.forename: Aud
authors.initials: A
authors.lastname: Svindland
authors.forename: Ragnhild A
authors.initials: RA
authors.lastname: Lothe
authors.forename: Arild
authors.initials: A
authors.lastname: Nesbakken
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology* / Q000235:genetics* / Q000556:secondary; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000473:pathology*; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D009664:Norway / Q000453:epidemiology; D010534:Peritoneal Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000556:secondary; D011446:Prospective Studies; D017678:Sex Distribution
chemical_list: D004273:DNA, Neoplasm