title: A nanomembrane-based nucleic acid sensing platform for portable diagnostics.
abstract: In this perspective article, we introduce a potentially transformative DNA/RNA detection technology that promises to replace DNA microarray and real-time PCR for field applications. It represents a new microfluidic technology that fully exploits the small spatial dimensions of a biochip and some new phenomena unique to the micro- and nanoscales. More specifically, it satisfies all the requisites for portable on-field applications: fast, small, sensitive, selective, robust, label- and reagent-free, economical to produce, and possibly PCR-free. We discuss the mechanisms behind the technology and introduce some preliminary designs, test results, and prototypes.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, USA.
authors.forename: Satyajyoti
authors.initials: S
authors.lastname: Senapati
authors.forename: Sagnik
authors.initials: S
authors.lastname: Basuray
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Slouka
authors.forename: Li-Jing
authors.initials: LJ
authors.lastname: Cheng
authors.forename: Hsueh-Chia
authors.initials: HC
authors.lastname: Chang
mesh_terms: D004247:DNA / Q000737:chemistry*; D003954:Diagnostic Services; D006801:Humans; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods*; D049329:Nanostructures; D020411:Oligonucleotide Array Sequence Analysis; D057285:Precision Medicine / Q000295:instrumentation
chemical_list: D004247:DNA