title: Cationic liposomes as gene delivery system: transfection efficiency and new application.
abstract: As it has been generally reported that oppositely charged cationic liposomes (CLs) are superior to either neutral or anionic liposomes as gene delivery carrier, interest in the properties, structures, transfection mechanism of CLs and so forth arises unprecedentedly. However, our understanding about the mechanism of CLs-gene complexes (lipoplex)-cell interaction and factors influencing the transfection efficiency (TE) of CLs remains poor. In this article, we describe some new results aimed at elucidating the relationship between the chemical-physical properties of lipoplex with TE and introducing recent applications of CLs in gene therapy.
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, P. R. China.
authors.forename: F
authors.initials: F
authors.lastname: Xiong
authors.forename: Z
authors.initials: Z
authors.lastname: Mi
authors.forename: N
authors.initials: N
authors.lastname: Gu
mesh_terms: D002412:Cations; D002478:Cells, Cultured; D004247:DNA / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers; D018014:Gene Transfer Techniques; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008968:Molecular Conformation; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D014162:Transfection / Q000379:methods
chemical_list: D002412:Cations; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D011092:Polyethylene Glycols; D004247:DNA