title: Diversity-driven chemical probe development for biomolecules: beyond hypothesis-driven approach.
abstract: Bioprobes are indispensable tools for biological study and clinical diagnosis. A conventional strategy for probe development is hypothesis-driven approach based on known molecular mechanisms of recognition for individual analytes. However, even the most sophisticated rational design does not always guarantee the applicability of probes in complex biological systems, therefore the efficiency and scope of probe development has been intrinsically limited. Diversity-driven approach is a rapidly emerging alternative and has been employed for the development of new probes even in the absence of the knowledge about target recognition mechanism. This tutorial review summarizes the recent advances in probe development along with conceptual advantages and perspectives of the diversity-driven approach.
authors.affiliation: Lab of Bioimaging Probe Development, Singapore Bioimaging Consortium, 11 Biopolis Way, # 02-02 Helios, Agency for Science, Technology and Research, Biopolis, Singapore 138667.
authors.forename: Nam-Young
authors.initials: NY
authors.lastname: Kang
authors.forename: Hyung-Ho
authors.initials: HH
authors.lastname: Ha
authors.forename: Seong-Wook
authors.initials: SW
authors.lastname: Yun
authors.forename: Young Hyun
authors.initials: YH
authors.lastname: Yu
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D000818:Animals; D032701:Biomimetics; D002477:Cells / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D057054:Molecular Imaging; D015335:Molecular Probes / Q000737:chemistry / Q000378:metabolism
chemical_list: D015335:Molecular Probes