title: [Chagas disease in the Netherlands: an estimate of the number of patients].
abstract: A total of 8-10 million persons are infected worldwide with Trypanosoma cruzi, the causative parasite of Chagas disease, most of whom are inhabitants of Latin America. Due to the increased migration of peoples, Chagas disease has been on the uprise outside Latin America, including in Europe. The course of Chagas, also called American trypanosomiasis, runs in 2 phases: an acute phase lasting approximately 2 months, and a chronic phase in which symptoms may appear years after infection. Without treatment, the patient will remain infected for life. The acute phase is usually asymptomatic; in the chronic phase of American trypanosomiasis, severe gastro-intestinal and cardiac abnormalities may develop, finally with fatal course. In the Netherlands, the number of immigrants who would serologically test positive for American trypanosomiasis is estimated to be between 726 and 2929. Healthcare providers in the Netherlands may encounter patients who have Chagas disease more and more frequently. The screening of pregnant women and blood donors at risk for American trypanosomiasis should be considered.
authors.affiliation: Academisch Medisch Centrum, Amsterdam, the Netherlands. a.bart@amc.uva.nl
authors.forename: Aldert
authors.initials: A
authors.lastname: Bart
authors.forename: Caspar J
authors.initials: CJ
authors.lastname: Hodiamont
authors.forename: Martin P
authors.initials: MP
authors.lastname: Grobusch
authors.forename: Reneé B A
authors.initials: RB
authors.lastname: van den Brink
authors.forename: André J P M
authors.initials: AJ
authors.lastname: Smout
authors.forename: Tom
authors.initials: T
authors.lastname: van Gool
mesh_terms: D001782:Blood Donors / Q000706:statistics & numerical data; D002598:Chagas Cardiomyopathy / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D014355:Chagas Disease / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D054242:Emigrants and Immigrants; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors; D014349:Trypanosoma cruzi