title: Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis.
abstract: A whole-genome scan using single marker association was used to detect chromosome regions associated with seven female fertility traits in Finnish Ayrshire dairy cattle. The phenotypic data consisted of de-regressed estimated breeding values for 340 bulls which were estimated using a single trait model. Genotypes were obtained with the Illumina BovineSNP50 panel and a total of 35 630 informative, high-quality single nucleotide polymorphism (SNP) markers were used. The association analysis was performed using a mixed-model approach which fitted a fixed effect for each SNP and a random polygenic effect. We detected eleven genome-wide significant associations on eight different chromosomes. With at least chromosome-wise significance after Bonferroni correction, sixteen SNPs on nine chromosomes showed significant associations with one or more fertility traits. The results confirmed quantitative trait loci on three chromosomes (1, 2 and 20) for fertility traits previously reported for the same breed and one on chromosome four previously detected in Holstein cattle.
authors.affiliation: MTT, Agrifood Research Finland, Biotechnology and Food Research, FIN-31600 Jokioinen, Finland. nina.schulman@mtt.fi
authors.forename: N F
authors.initials: NF
authors.lastname: Schulman
authors.forename: G
authors.initials: G
authors.lastname: Sahana
authors.forename: T
authors.initials: T
authors.lastname: Iso-Touru
authors.forename: S D
authors.initials: SD
authors.lastname: McKay
authors.forename: R D
authors.initials: RD
authors.lastname: Schnabel
authors.forename: M S
authors.initials: MS
authors.lastname: Lund
authors.forename: J F
authors.initials: JF
authors.lastname: Taylor
authors.forename: J
authors.initials: J
authors.lastname: Virta
authors.forename: J H
authors.initials: JH
authors.lastname: Vilkki
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping / Q000662:veterinary*; D005260:Female; D005298:Fertility / Q000235:genetics*; D005819:Genetic Markers; D016678:Genome; D055106:Genome-Wide Association Study; D005838:Genotype; D008297:Male; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci
chemical_list: D005819:Genetic Markers