title: Biomedical Ti-Mo alloys with surface machined and modified by laser beam: biomechanical, histological, and histometric analysis in rabbits.
abstract: OBJECTIVE
  In vivo bone response was assessed by removal torque, hystological and histometrical analysis on a recently developed biomedical Ti-15Mo alloy, after surface modification by laser beam irradiation, installed in the tibia of rabbits.
  
  
  METHODS
  A total of 32 wide cylindrical Ti-15Mo dental implants were obtained (10mm × 3.75mm). The implants were divided into two groups: 1) control samples (Machined surface - MS) and 2) implants with their surface modified by Laser beam-irradiation (Test samples - LS). Six implants of each surface were used for removal torque test and 10 of each surface for histological and histometrical analysis. The implants were placed in the tibial metaphyses of rabbits.
  
  
  RESULTS
  Average removal torque was 51.5Ncm to MS and >90Ncm to LS. Bone-to-implant-contact percentage was significantly higher for LS implants both in the cortical and marrow regions.
  
  
  CONCLUSIONS
  The present study demonstrated that laser treated Ti-15Mo alloys are promising materials for biomedical application.
authors.affiliation: Biomaterials Group, IQ, Universidade Estadual Paulista, UNESP, Araraquara, SP, Brazil. ntco@yahoo.com
authors.forename: Nilson T C
authors.initials: NT
authors.lastname: Oliveira
authors.forename: Fernando P S
authors.initials: FP
authors.lastname: Guastaldi
authors.forename: Vittoria
authors.initials: V
authors.lastname: Perrotti
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hochuli-Vieira
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Guastaldi
authors.forename: Adriano
authors.initials: A
authors.lastname: Piattelli
authors.forename: Giovanna
authors.initials: G
authors.lastname: Iezzi
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000528:radiation effects; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000528:radiation effects; D001696:Biomechanical Phenomena; D003722:Dental Alloys / Q000737:chemistry* / Q000528:radiation effects; D045662:Dental Etching / Q000379:methods*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004577:Electron Probe Microanalysis; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007834:Lasers; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000502:physiology; D011817:Rabbits; D013052:Spectrometry, X-Ray Emission; D013499:Surface Properties; D013977:Tibia / Q000033:anatomy & histology / Q000601:surgery*; D019415:Torque; D017155:Wettability
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D003722:Dental Alloys; D015921:Dental Implants; C525450:titanium molybdenum alloy