title: Histological analysis of autologous fascia graft implantation into the rabbit voice muscle.
abstract: The ideal approach for the treatment of glottal insufficiency remains a challenge for laryngologists.
  
  
  OBJECTIVE
  This experimental study assessed the histological changes and fibrosis caused by autologous fascia lata grafts into the rabbit voice muscle.
  
  
  METHODS
  A clinical and experimental study.
  
  
  METHODS
  A 0.2 × 0.2 cm fragment of autologous fascia lata was grafted into the right voice muscle of 14 adult rabbits. Animals were euthanized 30 or 60 days post-procedure and histology of the excised vocal folds was carried out.
  
  
  RESULTS
  No extensive edema, necrosis or foreign body-type reaction was observed at any time. No significant inflammatory reaction or fibrosis was seen at 30 or 60 days.
  
  
  CONCLUSIONS
  The presence of fascia lata in the rabbit voice muscle had no significant influence on inflammation, and does not increase fibrosis. Rabbit voice muscle shows good tolerance to fascia lata grafting.
authors.affiliation: Otorhinolaryngology and Head & Neck Surgery Department, UNIFESP- EPM. brpinna@yahoo.com.br
authors.forename: Bruno de Rezende
authors.initials: Bde R
authors.lastname: Pinna
authors.forename: João Norberto
authors.initials: JN
authors.lastname: Stavale
authors.forename: Paulo Augusto de Lima
authors.initials: PA
authors.lastname: Pontes
authors.forename: Osíris de Oliveira
authors.initials: Ode O
authors.lastname: Camponês do Brasil
mesh_terms: D000818:Animals; D005206:Fascia Lata / Q000637:transplantation*; D007249:Inflammation; D007821:Laryngeal Muscles / Q000473:pathology / Q000601:surgery*; D008297:Male; D011817:Rabbits; D014182:Transplantation, Autologous; D014827:Vocal Cords / Q000473:pathology / Q000601:surgery*