title: [Interpretation of the susceptibility test results in enterobacteria producing 3rd- and 4th-generation cephalosporin- or carbapenem-hydrolyzing beta-lactamases].
abstract: The interpretation of the susceptibility of Gram-negative rods to beta-lactams is currently under discussion in CLSI and EUCAST--two authorities on determination of clinical breakpoints. This article summarizes the current knowledge about clinical breakpoints in enterobacteria and proposes guidance for clinical microbiology laboratories in the Czech Republic.
authors.affiliation: Ustav mikrobiologie, Lékarská fakulta UK a Fakultní nemocnice v Plzni. Jaroslav.Hrabak@lfp.cuni.cz
authors.forename: J
authors.initials: J
authors.lastname: Hrabák
authors.forename: H
authors.initials: H
authors.lastname: Zemlicková
authors.forename: T
authors.initials: T
authors.lastname: Bergerová
authors.forename: P
authors.initials: P
authors.lastname: Urbásková
mesh_terms: D015780:Carbapenems / Q000493:pharmacokinetics / Q000494:pharmacology*; D002511:Cephalosporins / Q000493:pharmacokinetics / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology* / Q000378:metabolism; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000096:biosynthesis*; D047090:beta-Lactams / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D015780:Carbapenems; D002511:Cephalosporins; D047090:beta-Lactams; D001618:beta-Lactamases