title: Second harmonic inversion for ultrasound contrast harmonic imaging.
abstract: Ultrasound contrast agents (UCAs) are small micro-bubbles that behave nonlinearly when exposed to an ultrasound wave. This nonlinear behavior can be observed through the generated higher harmonics in a back-scattered echo. In past years several techniques have been proposed to detect or image harmonics produced by UCAs. In these proposed works, the harmonics generated in the medium during the propagation of the ultrasound wave played an important role, since these harmonics compete with the harmonics generated by the micro-bubbles. We present a method for the reduction of the second harmonic generated during nonlinear-propagation-dubbed second harmonic inversion (SHI). A general expression for the suppression signals is also derived. The SHI technique uses two pulses, p' and p″, of the same frequency f(0) and the same amplitude P(0) to cancel out the second harmonic generated by nonlinearities of the medium. Simulations show that the second harmonic is reduced by 40 dB on a large axial range. Experimental SHI B-mode images, from a tissue-mimicking phantom and UCAs, show an improvement in the agent-to-tissue ratio (ATR) of 20 dB compared to standard second harmonic imaging and 13 dB of improvement in harmonic power Doppler.
authors.affiliation: THORAXCENTER, Department of Biomedical Engineering Ee2302, Erasmus MC, Rotterdam, The Netherlands. mirza.pasovic@creatis.insa-lyon.fr
authors.forename: Mirza
authors.initials: M
authors.lastname: Pasovic
authors.forename: Mike
authors.initials: M
authors.lastname: Danilouchkine
authors.forename: Telli
authors.initials: T
authors.lastname: Faez
authors.forename: Paul L M J
authors.initials: PL
authors.lastname: van Neer
authors.forename: Christian
authors.initials: C
authors.lastname: Cachard
authors.forename: Antonius F W
authors.initials: AF
authors.lastname: van der Steen
authors.forename: Olivier
authors.initials: O
authors.lastname: Basset
authors.forename: Nico
authors.initials: N
authors.lastname: de Jong
mesh_terms: D003287:Contrast Media; D019047:Phantoms, Imaging; D011312:Pressure; D014465:Ultrasonics / Q000379:methods*
chemical_list: D003287:Contrast Media