title: Cytotoxic and antimicrobial activity of pseudopterosins and seco-pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea).
abstract: To expand the potential of pseudopterosins and seco-pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia islands (southwest Caribbean Sea), we report the anti-microbial profile against four pathogenic microorganisms (Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Candida albicans) and report a more complete cytotoxic profile against five human cells lines (HeLa, PC-3, HCT116, MCF-7 and BJ) for the compounds PsG, PsP, PsQ, PsS, PsT, PsU, 3-O-acetyl-PsU, seco-PsJ, seco-PsK and IMNGD. For the cytotoxic profiles, all compounds evaluated showed moderate and non-selective activity against both tumor and normal cell lines, where PsQ and PsG were the most active compounds (GI₅₀ values between 5.8 μM to 12.0 μM). With respect to their anti-microbial activity the compounds showed good and selective activity against the Gram-positive bacteria, while they did not show activity against the Gram-negative bacterium or yeast. PsU, PsQ, PsS, seco-PsK and PsG were the most active compounds (IC₅₀ 2.9-4.5 μM) against S. aureus and PsG, PsU and seco-PsK showed good activity (IC₅₀ 3.1-3.8 μM) against E. faecalis, comparable to the reference drug vancomycin (4.2 μM).
authors.affiliation: Departamento de Química, Universidad Nacional de Colombia, Bogotá D.C., Colombia. hcorreav@unal.edu.co
authors.forename: Hebelin
authors.initials: H
authors.lastname: Correa
authors.forename: Fabio
authors.initials: F
authors.lastname: Aristizabal
authors.forename: Carmenza
authors.initials: C
authors.lastname: Duque
authors.forename: Russell
authors.initials: R
authors.lastname: Kerr
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D017691:Caribbean Region; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D004224:Diterpenes; D006027:Glycosides; C049922:pseudopterosins; D014640:Vancomycin