title: Oxytocin in the periaqueductal grey regulates nociception in the rat.
abstract: Studies have demonstrated that oxytocin (OXT) plays important roles in pain modulation in the central nervous system, and there are OXT receptors in the periaqueductal grey (PAG). The experiment was designed to investigate the effect of OXT in the PAG on antinociception. The results showed that (1) intra-PAG injection of OXT increased the pain threshold, whereas the local administration of the high specific OXT receptor antagonist, desGly-NH(2), d(CH(2))(5)[D-Tyr(2), Thr-sup-4]OVT decreased the pain threshold in a dose-dependent manner; (2) Pain stimulation could elevate OXT concentration in the PAG perfusion liquid. The data suggested that OXT in the PAG was involved in the antinociceptive process through the OXT receptor.
authors.affiliation: School of Pharmacy, Xinxiang Medical University, Xixiang, Henan 453003, China. bcd2009@126.com
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Jin-Ying
authors.initials: JY
authors.lastname: Liang
authors.forename: Yan-Juan
authors.initials: YJ
authors.lastname: Pan
authors.forename: Xi-Qin
authors.initials: XQ
authors.lastname: Yan
authors.forename: Fu-Lin
authors.initials: FL
authors.lastname: Yan
authors.forename: Fang
authors.initials: F
authors.lastname: Hao
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Pei-Yong
authors.initials: PY
authors.lastname: Qiu
authors.forename: Da-Xin
authors.initials: DX
authors.lastname: Wang
mesh_terms: D000818:Animals; D008297:Male; D008845:Microinjections; D009951:Ornipressin / Q000031:analogs & derivatives / Q000494:pharmacology; D010121:Oxytocin / Q000378:metabolism / Q000502:physiology*; D010146:Pain / Q000378:metabolism* / Q000503:physiopathology; D010147:Pain Measurement; D017288:Pain Threshold; D010487:Periaqueductal Gray / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018045:Receptors, Oxytocin / Q000037:antagonists & inhibitors
chemical_list: D018045:Receptors, Oxytocin; C074541:vasotocin, desGly(NH2)(9)d(CH2)5-Tyr(Me)(2)-Thr(4)-Orn(8)-; D009951:Ornipressin; D010121:Oxytocin