title: An impedance QCM study on the partitioning of bioactive compounds in supported phospholipid bilayers.
abstract: The interaction of two drugs of small molecular size, propranolol and tetracaine, and the membrane-perturbing peptide melittin with a phospholipid bilayer supported on a SiO2 surface was studied with the quartz crystal microbalance. All three bioactive compounds interacted with the lipid bilayer and changed its viscoelastic properties. Adsorbed mass of the compounds was analyzed with a viscoelastic model as a function of the concentration of the compounds in the aqueous phase, as well as the effect of the compounds on the bilayer viscoelasticity. The analysis was based on the interpretation of the impedance of the crystal, utilizing the 5th, 7th and 9th overtone of the fundamental 5 MHz resonance frequency.
authors.affiliation: Aalto University, School of Chemical Technology, Department of Chemistry, PO Box 16100, 00076 Aalto, Finland.
authors.forename: Klaara
authors.initials: K
authors.lastname: Kannisto
authors.forename: Lasse
authors.initials: L
authors.lastname: Murtomäki
authors.forename: Tapani
authors.initials: T
authors.lastname: Viitala
mesh_terms: D000327:Adsorption / Q000187:drug effects; D004548:Elasticity / Q000187:drug effects; D017097:Electric Impedance; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D008555:Melitten / Q000494:pharmacology; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D058525:Quartz Crystal Microbalance Techniques; D012822:Silicon Dioxide / Q000737:chemistry; D013748:Tetracaine / Q000494:pharmacology; D013816:Thermodynamics; D014783:Viscosity / Q000187:drug effects; D014867:Water / Q000737:chemistry
chemical_list: D008051:Lipid Bilayers; D008081:Liposomes; D010743:Phospholipids; D014867:Water; D013748:Tetracaine; D008555:Melitten; D012822:Silicon Dioxide; D011433:Propranolol