title: Perifoveal exudative vascular anomalous complex.
abstract: OBJECTIVE
  To report the angiographic and optical coherence tomography (OCT) features of isolated "perifoveal exudative vascular anomalous complex (PEVAC)", a peculiar clinical entity.
  
  
  METHODS
  A complete ophthalmologic examination was performed in two patients (a 82-year old woman [case 1]; a 52-year old man [case 2]) that were referred to our department for unilateral blurred vision.
  
  
  RESULTS
  In both cases, fundus examination of the right eye showed a perifoveal isolated large aneurismal change, accompanied by small hemorrhages, intraretinal exudation, and small hard exudates accumulation. Both FA and ICGA revealed the absence of any other retinal or choroidal vascular abnormality associated. OCT showed a round hyperreflective lesion in correspondence of the perifoveal vascular anomalous complex, surrounded by intraretinal cystic spaces. In case 2, the lesion remained unchanged despite 3 monthly intravitreal injections of ranibizumab.
  
  
  CONCLUSIONS
  PEVAC may develop in absence of capillary ischemia or inflammation, probably due to progressive retinal endothelial cell degeneration. This could explain the unresponsiveness to anti-VEGF treatments.
authors.affiliation: Service d'ophtalmologie, centre hospitalier intercommunal de Créteil, université de Paris-XII, 40, avenue de Verdun, 94000 Créteil, France. giuseppe.querques@hotmail.it
authors.forename: G
authors.initials: G
authors.lastname: Querques
authors.forename: D
authors.initials: D
authors.lastname: Kuhn
authors.forename: N
authors.initials: N
authors.lastname: Massamba
authors.forename: N
authors.initials: N
authors.lastname: Leveziel
authors.forename: L
authors.initials: L
authors.lastname: Querques
authors.forename: E H
authors.initials: EH
authors.lastname: Souied
mesh_terms: D000369:Aged, 80 and over; D000783:Aneurysm / Q000150:complications* / Q000175:diagnosis; D020256:Choroidal Neovascularization / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008268:Macular Degeneration / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence; D054079:Vascular Malformations / Q000150:complications / Q000175:diagnosis; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology*