title: Compressed sensing with wavelet domain dependencies for coronary MRI: a retrospective study.
abstract: Coronary magnetic resonance imaging (MRI) is a noninvasive imaging modality for diagnosis of coronary artery disease. One of the limitations of coronary MRI is its long acquisition time due to the need of imaging with high spatial resolution and constraints on respiratory and cardiac motions. Compressed sensing (CS) has been recently utilized to accelerate image acquisition in MRI. In this paper, we develop an improved CS reconstruction method, Bayesian least squares-Gaussian scale mixture (BLS-GSM), that uses dependencies of wavelet domain coefficients to reduce the observed blurring and reconstruction artifacts in coronary MRI using traditional l(1) regularization. Images of left and right coronary MRI was acquired in 7 healthy subjects with fully-sampled k-space data. The data was retrospectively undersampled using acceleration rates of 2, 4, 6, and 8 and reconstructed using l(1) thresholding, l(1) minimization and BLS-GSM thresholding. Reconstructed right and left coronary images were compared with fully-sampled reconstructions in vessel sharpness and subjective image quality (1-4 for poor-excellent). Mean square error (MSE) was also calculated for each reconstruction. There were no significant differences between the fully sampled image score versus rate 2, 4, or 6 for BLS-GSM for both right and left coronaries (=N.S.). However, for l(1) thresholding significant differences were observed for rates higher than 2 and 4 for right and left coronaries respectively. l(1) minimization also yields images with lower scores compared to the reference for rates higher than 4 for both coronaries. These results were consistent with the quantitative vessel sharpness readings. BLS-GSM allows acceleration of coronary MRI with acceleration rates beyond what can be achieved with l(1) regularization.
authors.affiliation: School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. makcakay@bidmc.harvard.edu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akçakaya
authors.forename: Seunghoon
authors.initials: S
authors.lastname: Nam
authors.forename: Peng
authors.initials: P
authors.lastname: Hu
authors.forename: Mehdi H
authors.initials: MH
authors.lastname: Moghari
authors.forename: Long H
authors.initials: LH
authors.lastname: Ngo
authors.forename: Vahid
authors.initials: V
authors.lastname: Tarokh
authors.forename: Warren J
authors.initials: WJ
authors.lastname: Manning
authors.forename: Reza
authors.initials: R
authors.lastname: Nezafat
mesh_terms: D000328:Adult; D000465:Algorithms; D001499:Bayes Theorem; D003324:Coronary Artery Disease; D003331:Coronary Vessels / Q000033:anatomy & histology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D016018:Least-Squares Analysis; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016011:Normal Distribution; D012189:Retrospective Studies; D058067:Wavelet Analysis