title: Economic value of dengue vaccine in Thailand.
abstract: With several candidate dengue vaccines under development, this is an important time to help stakeholders (e.g., policy makers, scientists, clinicians, and manufacturers) better understand the potential economic value (cost-effectiveness) of a dengue vaccine, especially while vaccine characteristics and strategies might be readily altered. We developed a decision analytic Markov simulation model to evaluate the potential health and economic value of administering a dengue vaccine to an individual (≤ 1 year of age) in Thailand from the societal perspective. Sensitivity analyses evaluated the effects of ranging various vaccine (e.g., cost, efficacy, side effect), epidemiological (dengue risk), and disease (treatment-seeking behavior) characteristics. A ≥ 50% efficacious vaccine was highly cost-effective [< 1× per capita gross domestic product (GDP) ($4,289)] up to a total vaccination cost of $60 and cost-effective [< 3× per capita GDP ($12,868)] up to a total vaccination cost of $200. When the total vaccine series was $1.50, many scenarios were cost saving.
authors.affiliation: University of Pittsburgh School of Medicine, 200 Meyran Avenue, Pittsburgh, PA 15213, USA. BYL1@pitt.edu
authors.forename: Bruce Y
authors.initials: BY
authors.lastname: Lee
authors.forename: Diana L
authors.initials: DL
authors.lastname: Connor
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Kitchen
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Bacon
authors.forename: Mirat
authors.initials: M
authors.lastname: Shah
authors.forename: Shawn T
authors.initials: ST
authors.lastname: Brown
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Bailey
authors.forename: Yongjua
authors.initials: Y
authors.lastname: Laosiritaworn
authors.forename: Donald S
authors.initials: DS
authors.lastname: Burke
authors.forename: Derek A T
authors.initials: DA
authors.lastname: Cummings
mesh_terms: D003362:Cost-Benefit Analysis; D003715:Dengue / Q000276:immunology / Q000517:prevention & control*; D053059:Dengue Vaccines / Q000008:administration & dosage / Q000191:economics*; D006801:Humans; D013785:Thailand
chemical_list: D053059:Dengue Vaccines