title: Modulating drug loading and release profile of beta-cyclodextrin polymers by means of cross-linked degree.
abstract: The purpose of the present study is to use beta-cyclodextrin polymers (beta-CDP) with different cross-linked degree (CLD) to form inclusion complexes with ibuprofen and examine the effects of structural and compositional factors of beta-CDP on its drug loading and release behaviors. A series of beta-CDP with different CLD were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and 13C NMR spectrum. The beta-CDP was systemically characterized for the relation between the CLD of beta-CDP and the drug loading and release as well. The results of FT-IR and 13C NMR showed that similar peak-shaped vibration of beta-CDP and beta-CD implies that the polymer keeps the original characteristic structure of beta-CD. The CLD of the beta-CDP played a critical role in the drug loading and release, increasing the CLD resulted in reduction of drug loading, but increase in drug release.
authors.affiliation: College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Qi-fang
authors.initials: QF
authors.lastname: Wang
authors.forename: San-ming
authors.initials: SM
authors.lastname: Li
authors.forename: Yu-yang
authors.initials: YY
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
mesh_terms: D002247:Carbon Isotopes; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D002247:Carbon Isotopes; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers; D047392:beta-Cyclodextrins; C031215:betadex; D007052:Ibuprofen