title: Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arsenite-induced biochemical perturbation in mice.
abstract: The present study was undertaken to evaluate the protective effect of turmeric powder on arsenic toxicity through mice model. Swiss albino male mice were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were treated with turmeric powder (T, 50 mg/kg body weight/day), sodium arsenite (Sa, 10 mg/kg body weight/day) and turmeric plus Sa (T+Sa), respectively. Results showed that oral administration of Sa reduced the weight gain of the mice compared to the control group and food supplementation of turmeric prevented the reduction of weight gain. Turmeric abrogated the Sa-induced elevation of serum urea, glucose, triglyceride (TG) level and alanine aminotransferase (ALT) activity except the activity of alkaline phosphatase (ALP). Turmeric also prevented the Sa-induced perturbation of serum butyryl cholinesterase activity (BChE). Therefore, ameliorating effect of turmeric on Sa-treated mice suggested the future application of turmeric to reduce or to prevent arsenic toxicity in human.
authors.affiliation: Department of Applied Nutrition and Food Technology, Islamic University, Kushtia-7003, Bangladesh.
authors.forename: Md Rezaul
authors.initials: MR
authors.lastname: Karim
authors.forename: Abedul
authors.initials: A
authors.lastname: Haque
authors.forename: Khairul
authors.initials: K
authors.lastname: Islam
authors.forename: Nurshad
authors.initials: N
authors.lastname: Ali
authors.forename: Kazi Abdus
authors.initials: KA
authors.lastname: Salam
authors.forename: Zahangir Alam
authors.initials: ZA
authors.lastname: Saud
authors.forename: Ekhtear
authors.initials: E
authors.lastname: Hossain
authors.forename: Abul
authors.initials: A
authors.lastname: Fajol
authors.forename: Anwarul Azim
authors.initials: AA
authors.lastname: Akhand
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Himeno
authors.forename: Khaled
authors.initials: K
authors.lastname: Hossain
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D020261:Arsenic Poisoning / Q000517:prevention & control*; D018053:Arsenites / Q000506:poisoning; D030024:Curcuma; D019587:Dietary Supplements; D008297:Male; D051379:Mice; D028321:Plant Preparations / Q000008:administration & dosage*; D017670:Sodium Compounds / Q000506:poisoning
chemical_list: D000975:Antioxidants; D018053:Arsenites; D028321:Plant Preparations; D017670:Sodium Compounds; C017947:sodium arsenite