title: One-pot reductive amination and Suzuki-Miyaura cross-coupling of formyl aryl and heteroaryl MIDA boronates in array format.
abstract: Formyl-substituted aryl and heteroaryl MIDA boronates were prepared by a DMSO-free method and used in the first reported one-pot reductive amination-Suzuki-Miyaura cross-coupling sequence. This sequence was then carried out in parallel array format, using microwave-assisted in situ release cross-coupling of MIDA boronates to generate a library with diversity along two axes, affording rapid and convenient access to an array of druglike molecules.
authors.affiliation: Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. jonathan.grob@novartis.com
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Grob
authors.forename: Jill
authors.initials: J
authors.lastname: Nunez
authors.forename: Michael A
authors.initials: MA
authors.lastname: Dechantsreiter
authors.forename: Lawrence G
authors.initials: LG
authors.lastname: Hamann
mesh_terms: D000586:Amination; D001897:Boronic Acids / Q000737:chemistry*; D007098:Imino Acids; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D001897:Boronic Acids; D007098:Imino Acids; C533766:N-methyliminodiacetic acid