title: Thermography-measured effect of capsaicin, methylprednisolone and mitomycin on the survival of random skin flaps in rats.
abstract: OBJECTIVE
  This study was designed to determine if steroids, capsaicin and mitomycin improved skin flap survival in rats, and it has confirmed that thermography is an effective method to measured skin flap vitality.
  
  
  METHODS
  Forty female Wistar rats were randomised into four groups. A standardised full thickness inferiorly based dorsal random-pattern skin flap was raised, and a gelatine sponge was placed before suturing between the flap and its recipient bed, soaked with 0.9 % saline in the control group and with capsaicin, methylprednisolone and mitomycin in the experimental groups. Vitality of the flap and of the survival area was measured by infrared thermography.
  
  
  RESULTS
  Methylprednisolone statistically significant decrease skin flap necrosis, approximately 56%, when compared with controls (P< 0.05).
  
  
  CONCLUSIONS
  Corticosteroids applied subcutaneously in a single dose on a gelatine sponge produced a statistically significant improvement of the survival of random skin flaps in rats, whereas capsaicin and mitomycin showed no improvement.
authors.affiliation: School of Medicine, Division of Otorhinolaryngology, University of Zagreb, Pakrac County Hospital, Pakrac, Croatia. dr.azen@vip.hr
authors.forename: Dražen
authors.initials: D
authors.lastname: Shejbal
authors.forename: Petar
authors.initials: P
authors.lastname: Drvis
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bedekovic
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D002211:Capsaicin / Q000494:pharmacology*; D005260:Female; D005780:Gelatin; D005938:Glucocorticoids / Q000494:pharmacology; D006085:Graft Survival / Q000187:drug effects* / Q000502:physiology; D008775:Methylprednisolone / Q000494:pharmacology*; D016685:Mitomycin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018689:Sensory System Agents / Q000494:pharmacology; D012881:Skin Temperature / Q000187:drug effects; D013524:Surgical Flaps / Q000473:pathology / Q000502:physiology*; D015503:Surgical Sponges; D013817:Thermography
chemical_list: D000903:Antibiotics, Antineoplastic; D005938:Glucocorticoids; D018689:Sensory System Agents; D016685:Mitomycin; D005780:Gelatin; D002211:Capsaicin; D008775:Methylprednisolone