title: KRAS-mutation positive, metastatic tonsil carcinoma with cancer stem-like cell features and long-term response to gefitinib: a case report and review of the literature.
authors.affiliation: Thoraxklinik, University of Heidelberg, Heidelberg, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Gottschling
authors.forename: Roland
authors.initials: R
authors.lastname: Penzel
authors.forename: Tanja
authors.initials: T
authors.lastname: Pelz
authors.forename: Esther
authors.initials: E
authors.lastname: Herpel
authors.forename: Philipp A
authors.initials: PA
authors.lastname: Schnabel
authors.forename: Gerhard
authors.initials: G
authors.lastname: Dyckhoff
authors.forename: Michael
authors.initials: M
authors.lastname: Thomas
authors.forename: Thomas
authors.initials: T
authors.lastname: Kuhnt
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D000077156:Gefitinib; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009154:Mutation; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D011799:Quinazolines / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014067:Tonsillar Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D016896:Treatment Outcome; D018631:ras Proteins / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; C117307:KRAS protein, human; D047428:Protein Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D011799:Quinazolines; C512478:EGFR protein, human; D066246:ErbB Receptors; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins; D000077156:Gefitinib