title: Phenolic compounds with NF-κB inhibitory effects from the fungus Phellinus baumii.
abstract: Chemical investigation of the fungus Phellinus baumii has resulted in characterization of five previously undescribed hispidin derivatives, phellibaumins A-E (1-5), as well as two pairs of new non-equivalent epimeric benzyl dihydroflavones, methylphelligrin A (9), epi-methylphelligrin A (10), methylphelligrin B (11), and epi-methylphelligrin B (12), together with five known compounds, interfungin B (6), phelligridin H (7), phelligridimer A (8), phelligrin A (13), and epi-phelligrin A (14). Phellibaumin A (1) was a novel hispidin derivative with a unique 3,4-dihydroxybenzofuran unit. These compounds exhibited NF-κB inhibitory activity with IC(50) values of 52.96 μM (1), 41.40 μM (2), 52.92 μM (5), 36.44 μM (9 and 10), and 22.46 μM (11 and 12), respectively.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, People's Republic of China.
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Wu
authors.forename: Zhao-Min
authors.initials: ZM
authors.lastname: Lin
authors.forename: Li-Ning
authors.initials: LN
authors.lastname: Wang
authors.forename: Dong-Xiao
authors.initials: DX
authors.lastname: Guo
authors.forename: Shu-Qi
authors.initials: SQ
authors.lastname: Wang
authors.forename: Yong-Qing
authors.initials: YQ
authors.lastname: Liu
authors.forename: Hui-Qing
authors.initials: HQ
authors.lastname: Yuan
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000276:immunology; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D016328:NF-kappa B; D010636:Phenols; D011753:Pyrones; C007946:hispidin