title: Quantitative evaluation of extraction socket healing following the use of autologous platelet-rich fibrin matrix in humans.
abstract: Platelet-rich fibrin matrix (PRFM) is an autologous biologic material created by centrifugation of blood. This study quantified ridge changes associated with the healing of 21 extraction sites using PRFM alone as a graft. Standardized measurements of ridge width and height were recorded at extraction, after graft placement, and after 4 months of healing. Mean width resorption 3 and 5 mm apical to the crest was 0.32 mm (4.71% loss) and 0.57 mm (7.38% loss), respectively. Mean height resorption was 0.67 mm (7.13% loss). Sites grafted with PRFM alone displayed rapid clinical healing, minimal flap reopening, and excellent bone density. Advantages of PRFM alone include less surgical time, elimination of techniques and potential healing difficulties associated with membranes, and less resorption during healing, as compared to guided bone regeneration procedures.
authors.affiliation: Department of Periodontics, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA. simonbi@umdnj.edu
authors.forename: Barry I
authors.initials: BI
authors.lastname: Simon
authors.forename: Priyu
authors.initials: P
authors.lastname: Gupta
authors.forename: Shereen
authors.initials: S
authors.lastname: Tajbakhsh
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000517:prevention & control*; D002965:Classification; D005260:Female; D005337:Fibrin / Q000737:chemistry / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
chemical_list: D006133:Growth Substances; D005337:Fibrin