title: Seizure control: a secondary benefit of chemotherapeutic temozolomide in brain cancer patients.
abstract: The severity of brain tumor associated seizures often mirror the growth of the underlying tumor, and may be intractable to conventional antiepileptic drugs. We present a patient with intractable seizures in the setting of a low grade glioma who responded dramatically to temozolomide despite minimal radiographic change in tumor size. Temozolomide is an effective treatment for seizure control in patients with brain tumors.
authors.affiliation: Department of Neurosciences, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Hu
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Xu
authors.forename: Ryan Y
authors.initials: RY
authors.lastname: Kim
authors.forename: Angel
authors.initials: A
authors.lastname: Nguyen
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Santosh
authors.initials: S
authors.lastname: Kesari
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D001254:Astrocytoma / Q000150:complications; D001932:Brain Neoplasms / Q000150:complications / Q000188:drug therapy*; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004569:Electroencephalography; D005260:Female; D006801:Humans; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide