title: Autocrine motility factor and its receptor expressions in human oral squamous cell carcinoma (SCC) cells.
abstract: Autocrine motility factor (AMF) a tumor-secreted 55 kDa cytokine induces tumor cell motility by a signal transduction pathway mediated by interaction with its receptor (AMFR) a cell surface glycoprotein of 78 kDa (gp78). Here, AMF secreted by the metastatic LMF4 human oral squamous-cell carcinoma (SCC) cells, induced dose- and time-dependent morphological changes and chemotaxis of the producing cells. Expression of AMFR mRNA was associated with the metastatic ability of SCC cell variants. The data presented show for the first time that SCC cells produce AMF and express AMFR and the expression is related to their invasiveness and metastatic potentials.
authors.affiliation: KARMANOS CANC INST,TUMOR PROGRESS & METASTASIS PROGRAM,DETROIT,MI 48201. WAYNE STATE UNIV,DEPT RADIAT ONCOL,DETROIT,MI 48201. WAYNE STATE UNIV,DEPT PATHOL,DETROIT,MI 48201. UNIV TOKYO,FAC DENT,DEPT BIOCHEM,BUNKYO KU,TOKYO 113,JAPAN. UNIV TOKYO,FAC DENT,DEPT ORAL & MAXILLOFACIAL SURG,BUNKYO KU,TOKYO 113,JAPAN. TORIDE KYODO GEN HOSP,DEPT ORAL SURG,TORIDE,IBARAKI 302,JAPAN. GUNMA UNIV,SCH MED,DEPT ORTHOPAED SURG,MAEBASHI,GUMMA 371,JAPAN.
authors.forename: Y
authors.initials: Y
authors.lastname: Niinaka
authors.forename: S
authors.initials: S
authors.lastname: Oida
authors.forename: A
authors.initials: A
authors.lastname: Ishisaki
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Iimura
authors.forename: Y
authors.initials: Y
authors.lastname: Maruoka
authors.forename: F
authors.initials: F
authors.lastname: Momose
authors.forename: A
authors.initials: A
authors.lastname: Negishi
authors.forename: H
authors.initials: H
authors.lastname: Ichijo
authors.forename: T
authors.initials: T
authors.lastname: Amagasa
authors.forename: S
authors.initials: S
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Raz