title: Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
abstract: Four new norsesquiterpene peroxides, named talaperoxides A-D (1-4), as well as one known analogue, steperoxide B (5, or merulin A), have been isolated from a mangrove endophytic fungus, Talaromyces flavus. Their structures were elucidated mainly by 1D and 2D NMR. Structures of 1, 2, and 5 were further confirmed by single-crystal X-ray diffraction, and their absolute configurations were also determined using copper radiation. Cytotoxic activities of compounds 1-5 were evaluated in vitro against human cancer cell lines MCF-7, MDA-MB-435, HepG2, HeLa, and PC-3. Compounds 2 and 4 showed cytotoxicity against the five human cancer cell lines with IC50 values between 0.70 and 2.78 μg/mL.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
authors.forename: Hanxiang
authors.initials: H
authors.lastname: Li
authors.forename: Hongbo
authors.initials: H
authors.lastname: Huang
authors.forename: Changlun
authors.initials: C
authors.lastname: Shao
authors.forename: Huarong
authors.initials: H
authors.lastname: Huang
authors.forename: Jieyi
authors.initials: J
authors.lastname: Jiang
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu
authors.forename: Yayue
authors.initials: Y
authors.lastname: Liu
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Lu
authors.forename: Mengfeng
authors.initials: M
authors.lastname: Li
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D043982:Rhizophoraceae / Q000382:microbiology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032901:Talaromyces / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010545:Peroxides; D012717:Sesquiterpenes