title: [Effects of drugs for lifestyle-related diseases on bone metabolism].
abstract: Accumulating evidence indicates several drugs for lifestyle-related diseases are involved in bone metabolism. Drugs that might reduce fracture incidence are statins, β-blockers and thiazide diuretics, and those that might increase fractures are thiazolidinediones and loop diuretics. It is yet controversial whether ACE inhibitors, angiotensin receptor- II blockers and aldosterone receptor antagonists are indeed involved in the increase or the decrease in fracture incidence.
authors.affiliation: Tonarnomon Hospital Endocrine Center.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takeuchi
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D057911:Angiotensin Receptor Antagonists / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D001842:Bone and Bones / Q000378:metabolism*; D050723:Fractures, Bone / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008019:Life Style; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology; D012306:Risk; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000009:adverse effects / Q000494:pharmacology; D045162:Thiazolidinediones / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000451:Mineralocorticoid Receptor Antagonists; D049993:Sodium Chloride Symporter Inhibitors; D049994:Sodium Potassium Chloride Symporter Inhibitors; D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione