title: Coverage of gingival recession defects using guided tissue regeneration with and without adjunctive enamel matrix derivative in a dog model.
abstract: The aim of this study was to clarify the adjunctive effect of enamel matrix derivative (EMD) on expanded polytetrafluoroethylene membrane guided tissue regeneration (GTR)-based root coverage by creating gingival recessions in beagle dogs. Recessions were treated with GTR + EMD, GTR alone, or neither GTR nor EMD (control). The control group was characterized by long junctional epithelium and little bone formation. The GTR + EMD group showed a statistically significant increase (P < .01) in new bone and cementum formation compared with the GTR group. The results of the present investigation suggest that the adjunctive use of EMD with GTR promotes formation of new bone and cementum without root resorption in recession-type defects in dogs.
authors.affiliation: Department of Periodontology, Tokyo Dental College, Chiba, Japan. ryyamada@tdc.ac.jp
authors.forename: Takahisa
authors.initials: T
authors.lastname: Fujita
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Mikio
authors.initials: M
authors.lastname: Ota
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Shibukawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamada
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000494:pharmacology; D025021:Cementogenesis / Q000187:drug effects; D003746:Dental Enamel Proteins / Q000494:pharmacology; D004285:Dogs; D005889:Gingival Recession / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D020007:Implants, Experimental; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene
chemical_list: D018786:Bone Substitutes; D003746:Dental Enamel Proteins; D008567:Membranes, Artificial; C109069:enamel matrix proteins; D011138:Polytetrafluoroethylene