title: Quantitative assessment of photoreceptor layer in eyes with resolved edema after pars plana vitrectomy with internal limiting membrane removal for diabetic macular edema.
abstract: OBJECTIVE
  To evaluate the correlation between visual acuity (VA) and photoreceptor integrity in eyes with resolved diabetic macular edema (DME) after pars plana vitrectomy (PPV).
  
  
  METHODS
  Eleven eyes with resolved macular edema following PPV with internal limiting membrane removal for DME were included in this retrospective study. The integrity of the external limiting membrane (ELM) and inner and outer segments (IS/OS) of the photoreceptor junction was evaluated by spectral domain optical coherence tomography. The main outcome measures were percentage of disrupted ELM and IS/OS lines, and correlation between VA and photoreceptor integrity.
  
  
  RESULTS
  The mean time after PPV was 78 ± 17 months. The mean lengths of the disrupted ELM and IS/OS lines were 223 ± 167 μm (63%) and 189 ± 175 μm (54%) in the foveola, and 900 ± 522 μm (60%) and 835 ± 582 μm (55%) in the fovea, respectively. Intact ELM and IS/OS lines were positively correlated with VA in both the fovea (p = 0.09 and p = 0.02, respectively) and foveola (p = 0.004 and p = 0.03, respectively). Linear regression analysis showed a statistically significant association of intact ELM and IS/OS lines with VA in the fovea. Disrupted ELM and IS/OS lines had a strong correlation with each other in both the fovea (r = -0.71, p = 0.013) and foveola (r = 0.81, p = 0.02).
  
  
  CONCLUSIONS
  The integrity of the ELM and IS/OS lines was positively correlated with VA in eyes with resolved DME after PPV.
authors.affiliation: Department of Ophthalmology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey. dr@atesyanyali.com
authors.forename: Ates
authors.initials: A
authors.lastname: Yanyali
authors.forename: Kansu T
authors.initials: KT
authors.lastname: Bozkurt
authors.forename: Aydin
authors.initials: A
authors.lastname: Macin
authors.forename: Fatih
authors.initials: F
authors.lastname: Horozoglu
authors.forename: Ahmet F
authors.initials: AF
authors.lastname: Nohutcu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000601:surgery*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003930:Diabetic Retinopathy / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008269:Macular Edema / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D014821:Vitrectomy