title: Temsirolimus is highly effective as third-line treatment in chromophobe renal cell cancer.
abstract: We report unexpectedly high efficacy of temsirolimus as third-line treatment in a patient with metastatic chromophobe renal cell carcinoma. After failure of two sequentially administered tyrosine kinase inhibitors, treatment with temsirolimus resulted in a prolonged partial remission of 14 months, and the response is still continuing. Up to now, no data from randomized clinical studies have been published addressing the question of efficacy of temsirolimus as third-line treatment after failure of tyrosine kinase inhibitors. The case presented here implies that temsirolimus could be a viable option for patients with metastatic chromophobe renal cell carcinoma.
authors.affiliation: Department of Oncology, University Hospital Zürich, Zürich, Switzerland.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Zardavas
authors.forename: Alexander
authors.initials: A
authors.lastname: Meisel
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Samaras
authors.forename: Alexander
authors.initials: A
authors.lastname: Knuth
authors.forename: Christoph
authors.initials: C
authors.lastname: Renner
authors.forename: Bernhard C
authors.initials: BC
authors.lastname: Pestalozzi
authors.forename: Frank
authors.initials: F
authors.lastname: Stenner-Liewen