title: [Hyperfibrinolysis as the cause of haemorrhage and increased mortality in trauma patients].
abstract: Trauma-associated coagulopathies are at times present upon arrival at the emergency department. Hyperfibrinolysis is a condition in which the natural ability to dissolve blood clots is pathologically enhanced. It is present in 2-8% of trauma patients and associated with shock and increased mortality. Hyperfibrinolysis is easily detected by thromboelastography. The condition is treated with antifibrinolytics such as tranexamic acid--whereas transfusion with blood products is inefficient. This article explores the mechanisms and diagnostics of hyperfibrinolysis in trauma patients and the relevant treatment options.
authors.affiliation: Anæstesiologisk Afdeling, Herlev Hospital, 2730 Herlev. wikkelso@gmail.com
authors.forename: Anne Juul
authors.initials: AJ
authors.lastname: Wikkelsø
authors.forename: Arash
authors.initials: A
authors.lastname: Afshari
authors.forename: Jakob
authors.initials: J
authors.lastname: Stensballe
authors.forename: Pär I
authors.initials: PI
authors.lastname: Johansson
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D001803:Blood Transfusion; D005342:Fibrinolysis; D006470:Hemorrhage / Q000097:blood* / Q000209:etiology / Q000401:mortality; D006801:Humans; D012771:Shock, Hemorrhagic / Q000097:blood / Q000401:mortality; D013916:Thrombelastography; D014148:Tranexamic Acid / Q000627:therapeutic use; D014947:Wounds and Injuries / Q000097:blood* / Q000401:mortality
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid