title: Iloprost reduces colonic injury in ischemic colitis in rats.
abstract: OBJECTIVE
  Evaluate the effects of iloprost administration in the early period of ischemic colitis and the mechanism that how these effects develop.
  
  
  METHODS
  Thirty two Wistar albino female rats with an average weight of 220g were divided into four groups of eight rats. In group 1 the rats were given iloprost and sacrificed after 24 hours and in group 2 they were sacrificed after 24 hours without any iloprost. The rats in group 3 were administrated iloprost and sacrificed after 72 hours and in group 4 they were sacrificed at 72th hour without iloprost. The differences between the groups as tissue damage, vascularization or apoptosis were assessed statistically.
  
  
  RESULTS
  Oxidative damage and apoptosis were less pronounced and vascularization was better developed in rats that were given iloprost and sacrificed at 24th hour later in contrast to the rats that were not treated with iloprost. But there was no statistical difference among the groups at 72th hour.
  
  
  CONCLUSIONS
  Iloprost inhibited leucocyte infiltration, decreased proinflammatory cytokines and enhanced angiogenesis so that the oxidative stress and inflammatory response decreased resulting in lesser tissue damage.
authors.affiliation: Okmeydani Research Hospital, General Surgery Department, Istanbul, Turkey. drkaratepe@yahoo.com
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Karatepe
authors.forename: Affan
authors.initials: A
authors.lastname: Cakir
authors.forename: Orçun
authors.initials: O
authors.lastname: Unal
authors.forename: Muharrem
authors.initials: M
authors.lastname: Battal
authors.forename: Gokhan
authors.initials: G
authors.lastname: Adas
authors.forename: Gülcin
authors.initials: G
authors.lastname: Kamali
authors.forename: Ahu
authors.initials: A
authors.lastname: Kemik
authors.forename: Timucin
authors.initials: T
authors.lastname: Aydin
authors.forename: Sedat
authors.initials: S
authors.lastname: Kamali
authors.forename: Servet R
authors.initials: SR
authors.lastname: Karahan
authors.forename: Murat
authors.initials: M
authors.lastname: Aksoy
mesh_terms: D000818:Animals; D017091:Colitis, Ischemic / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D005260:Female; D016285:Iloprost / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010975:Platelet Aggregation Inhibitors; D016285:Iloprost