title: A new route to α-alkyl-α-fluoromethylenebisphosphonates.
abstract: A new route to α-alkyl-α-fluoromethylenebisphosphonates, 2 has been developed starting from commercially available tetraethyl fluoromethylenebisphosphonate (1), and alkyl halides using either caesium carbonate in DMF or sodium dimsyl. De-esterification of 2 provided biologically important α-alkyl-α-fluoromethylenebisphosphonic acid, 3, while alkoxide-induced carbon-phosphorus bond cleavage of 2 gave α-fluorophosphonates, 4, which are useful synthons in organic synthesis.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10, Prague 6, Czech Republic. beier@uochb.cas.cz
authors.forename: Petr
authors.initials: P
authors.lastname: Beier
authors.forename: Stanislav
authors.initials: S
authors.lastname: Opekar
authors.forename: Mikhail
authors.initials: M
authors.lastname: Zibinsky
authors.forename: Inessa
authors.initials: I
authors.lastname: Bychinskaya
authors.forename: G K Surya
authors.initials: GK
authors.lastname: Prakash
mesh_terms: D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009943:Organophosphorus Compounds