title: Multi-objective optimization of glycopeptide antibiotic production in batch and fed batch processes.
abstract: Fermentation optimization involves potentially conflicting multiple objectives such as product concentration and production media cost. Simultaneous optimization of these objectives would result in a multiobjective optimization problem, which is characterized by a set of multiple solutions, knows as pareto optimal solutions. These solutions gives flexibility in evaluating the trade-offs and selecting the most suitable operating policy. Here, ε-constraint approach was used to generate the pareto solutions for two objectives: product concentration and product per unit cost of media, for batch and fed batch operations using process model for Amycolatopsis balhimycina, a glycopeptide antibiotic producer. This resulted in a set of several pareto optimal solutions with the two objectives ranging from (0.75 g l(-1), 3.97 g $(-1)) to (0.44 g l(-1), 5.19 g $(-1)) for batch and from (1.5 g l(-1), 5.46 g $(-1)) to (1.1 g l(-1), 6.34 g $(-1)) for fed batch operations. One pareto solution each for batch and for fed batch mode was experimentally validated.
authors.affiliation: Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
authors.forename: Soumen K
authors.initials: SK
authors.lastname: Maiti
authors.forename: Anna Eliasson
authors.initials: AE
authors.lastname: Lantz
authors.forename: Mani
authors.initials: M
authors.lastname: Bhushan
authors.forename: Pramod P
authors.initials: PP
authors.lastname: Wangikar
mesh_terms: D000192:Actinomycetales / Q000187:drug effects / Q000254:growth & development; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D019149:Bioreactors / Q000382:microbiology; D001709:Biotechnology / Q000379:methods*; D002244:Carbon / Q000494:pharmacology; D005285:Fermentation / Q000187:drug effects; D006020:Glycopeptides / Q000096:biosynthesis*; D015203:Reproducibility of Results
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D002244:Carbon