title: AA amyloidosis associated with hepatitis B.
abstract: We report a 13-year-old Indian boy with nephrotic syndrome caused by renal AA amyloidosis. Workup of the AA amyloidosis revealed chronic hepatitis B. Laser microdissection of the Congo-red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry confirmed the presence of serum amyloid A (SAA) protein and ruled out hereditary and familial amyloidosis. Furthermore, mass spectrometry also detected a variant of SAA protein (SAA W71R).
authors.affiliation: Division of Pediatric Nephrology, PGIMER & Associated Dr RML Hospital, New Delhi, India. sethi.sanjeev@mayo.edu
authors.forename: Abhijeet
authors.initials: A
authors.lastname: Saha
authors.forename: Jason D
authors.initials: JD
authors.lastname: Theis
authors.forename: Julie A
authors.initials: JA
authors.lastname: Vrana
authors.forename: Nand K
authors.initials: NK
authors.lastname: Dubey
authors.forename: Vineeta V
authors.initials: VV
authors.lastname: Batra
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Sethi
mesh_terms: D000595:Amino Acid Sequence; D000686:Amyloidosis / Q000150:complications* / Q000378:metabolism; D002648:Child; D002853:Chromatography, Liquid; D006509:Hepatitis B / Q000150:complications* / Q000378:metabolism; D006515:Hepatitis B virus / Q000472:pathogenicity*; D006801:Humans; D007678:Kidney Glomerulus / Q000503:physiopathology*; D007834:Lasers; D008297:Male; D042282:Microdissection; D008969:Molecular Sequence Data; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000378:metabolism; D011379:Prognosis; D000685:Serum Amyloid A Protein / Q000378:metabolism; D053719:Tandem Mass Spectrometry
chemical_list: D000685:Serum Amyloid A Protein