title: Azaphilones from the endophyte Chaetomium globosum.
abstract: Six new azaphilones, 5'-epichaetoviridin A (7), 4'-epichaetoviridin F (9), 12β-hydroxychaetoviridin C (10), and chaetoviridins G-I (11-13), and six known azaphilones, chaetoviridins A-E (1-5) and 4'-epichaetoviridin A (8), were isolated from the endophytic fungus Chaetomium globosum cultivated in PDB medium for 21 days. The structure elucidation and the assignment of the relative configurations of the new natural products were based on detailed NMR and MS spectroscopic analyses. The structure of compound 1 was confirmed by single-crystal X-ray diffraction analysis. The absolute configurations of compounds 4, 7, 8, and 12 were determined using Mosher's method. The antibiotic activity of the compounds was evaluated using an in vivo Caenorhabditis elegans infection model.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo , 14040-903, Ribeirão Preto, SP, Brazil.
authors.forename: Warley S
authors.initials: WS
authors.lastname: Borges
authors.forename: Gabriela
authors.initials: G
authors.lastname: Mancilla
authors.forename: Denise O
authors.initials: DO
authors.lastname: Guimarães
authors.forename: Rosa
authors.initials: R
authors.lastname: Durán-Patrón
authors.forename: Isidro G
authors.initials: IG
authors.lastname: Collado
authors.forename: Mônica T
authors.initials: MT
authors.lastname: Pupo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000382:microbiology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000187:drug effects; D002597:Chaetomium / Q000737:chemistry*; D004195:Disease Models, Animal; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D010860:Pigments, Biological; C494154:azaphilone