title: Travel-related dengue virus infection, The Netherlands, 2006-2007.
abstract: To assess the incidence of and risk factors for clinical and subclinical dengue virus (DENV) infection, we prospectively studied 1,207 adult short-term travelers from the Netherlands to dengue-endemic areas. Participants donated blood samples for serologic testing before and after travel. Blood samples were tested for antibodies against DENV. Seroconversion occurred in 14 (1.2%) travelers at risk. The incidence rate was 14.6 per 1,000 person-months. The incidence rate was significantly higher for travel during the rainy months. Dengue-like illness occurred in 5 of the 14 travelers who seroconverted. Seroconversion was significantly related to fever, retro-orbital pain, myalgia, arthralgia, and skin rash. The risk for DENV infection for short-term travelers to dengue-endemic areas is substantial. The incidence rate for this study is comparable with that in 2 other serology-based prospective studies conducted in the 1990s.
authors.affiliation: Department of Infectious Diseases, Public Health Service, Amsterdam, The Netherlands. gijsbaaten@hotmail.com
authors.forename: Gijs G G
authors.initials: GG
authors.lastname: Baaten
authors.forename: Gerard J B
authors.initials: GJ
authors.lastname: Sonder
authors.forename: Hans L
authors.initials: HL
authors.lastname: Zaaijer
authors.forename: Tom
authors.initials: T
authors.lastname: van Gool
authors.forename: Joan A P C M
authors.initials: JA
authors.lastname: Kint
authors.forename: Anneke
authors.initials: A
authors.lastname: van den Hoek
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D003715:Dengue / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission*; D003716:Dengue Virus / Q000276:immunology / Q000502:physiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012698:Serologic Tests; D014195:Travel
chemical_list: D000914:Antibodies, Viral