title: [Measurement of renal function in clinical practice: principles and limitations].
abstract: Methods for measurement of glomerular filtration rate (GFR) (clearance in plasma, urine or both of an « exogenous » tracer, usually radio labeled) often are considered impractical from a clinical standpoint. Alternate methods proposed to estimate the GFR are based on plasma levels of « endogenous » tracers (creatinine, cystatin C). These methods are so imprecise that they provide little if any true reassurance with regards to warnings and recommended GFR values for the use of iodinated and gadolinium based contrast agents.
authors.affiliation: Service de Biophysique et Médecine Nucléaire, Centre Hospitalier de Bicêtre, 78 rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. alain.prigent@bct.aphp.fr
authors.forename: A
authors.initials: A
authors.lastname: Prigent
mesh_terms: D002860:Chromium Radioisotopes; D003287:Contrast Media / Q000493:pharmacokinetics; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000503:physiopathology; D004492:Edetic Acid; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007457:Iodine Radioisotopes; D007483:Iothalamic Acid; D007677:Kidney Function Tests; D008297:Male; D012016:Reference Values; D051437:Renal Insufficiency / Q000175:diagnosis* / Q000503:physiopathology; D012680:Sensitivity and Specificity
chemical_list: D002860:Chromium Radioisotopes; D003287:Contrast Media; D055316:Cystatin C; D007457:Iodine Radioisotopes; D007483:Iothalamic Acid; D004492:Edetic Acid; D003404:Creatinine