title: FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair.
abstract: Fanconi anemia (FA) is a rare genetic disease characterized by congenital abnormalities, bone marrow failure and heightened cancer susceptibility. The FA proteins are known to function in the cellular defense against DNA interstrand crosslinks (ICLs), a process that remains poorly understood. A recent spate of discoveries has led to the identification of one new FA gene, FANCP/SLX4, and two strong candidate FA genes, FAN1 and RAD51C. In this perspective we describe the discovery of FANCP/SLX4 and discuss how these new findings collectively refine our understanding of DNA ICL repair.
authors.affiliation: University of Rhode Island, Kingston, RI, USA.
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Cybulski
authors.forename: Niall G
authors.initials: NG
authors.lastname: Howlett
mesh_terms: D004260:DNA Repair; D005199:Fanconi Anemia / Q000235:genetics*; D051856:Fanconi Anemia Complementation Group Proteins / Q000235:genetics*; D006801:Humans; D045522:Recombinases / Q000235:genetics*
chemical_list: D051856:Fanconi Anemia Complementation Group Proteins; D045522:Recombinases; C542319:SLX4 protein, human