title: [Small-dose vardenafil restores erectile function after penile surgery].
abstract: OBJECTIVE
  To investigate the impact of penile surgery on the erectile function of the patient and to evaluate the role of small-dose vardenafil in restoring the impaired penile erection.
  
  
  METHODS
  Sixty cases of penile cavernosum surgery were equally and randomly divided into a vardenafil and a control group, the former treated 5 - 7 days after surgery with 10 mg vardenafil every other day, while the latter given vitamin E at 100 mg once a day, both for 12 weeks. The penile erectile function of the patients was evaluated with the IIEF-5 questionnaire before surgery and at 3 and 6 months after vardenafil medication.
  
  
  RESULTS
  The mean IIEF-5 scores of the vardenafil group were 18.83 +/- 2.98 and 20.13 +/- 2.98 at 3 and 6 months after vardenafil medication, significantly higher than 14.21 +/- 3.62 before surgery (P > 0.05), while that of the control group was significantly decreased at 3 months as compared with the preoperative score (13.38 +/- 2.82 versus 15.80 +/- 3.02, P < 0.05). The vardenafil group showed the highest IIEF-5 score after surgery (P < 0.05).
  
  
  CONCLUSIONS
  Long-term administration of small-dose vardenafil after penile surgery helps to restore and maintain penile erectile function.
authors.affiliation: Department of Urology, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
authors.forename: Geng-Sheng
authors.initials: GS
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Da
authors.forename: Guo-Qin
authors.initials: GQ
authors.lastname: Dong
authors.forename: Yue-Qing
authors.initials: YQ
authors.lastname: Jiang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Zhi-Kang
authors.initials: ZK
authors.lastname: Cai
mesh_terms: D000328:Adult; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010410:Penile Erection; D010413:Penis / Q000601:surgery; D010879:Piperazines / Q000008:administration & dosage* / Q000627:therapeutic use; D011184:Postoperative Period; D020127:Recovery of Function; D013450:Sulfones / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use; D000069058:Vardenafil Dihydrochloride; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D007093:Imidazoles; D010879:Piperazines; D013450:Sulfones; D014227:Triazines; D014665:Vasodilator Agents; D000069058:Vardenafil Dihydrochloride