title: [Pentosan polysulfide sodium for chronic non-bacterial prostatitis in the rat model].
abstract: OBJECTIVE
  To investigate the therapeutic effect of pentosan polysulfide sodium (PPS) on chronic non-bacterial prostatitis (CNP) in rats.
  
  
  METHODS
  Based on Robinette's method, we established a CNP model in 80 male SD rats, aged 6 months and weighing 315 - 450 g, by castration followed by subcutaneous injection of estradiol at 0.25 mg / (kg x d) for 30 consecutive days. Then we randomly allocated the model rats into a placebo group (n = 40) and a PPS group (n = 40) to receive intragastric administration of normal saline and PPS, respectively. After 8 weeks of treatment, the pathological changes in the rat prostatic tissue were observed by HE staining.
  
  
  RESULTS
  Varied degrees of chronic inflammation and inflammatory cell infiltration were seen in the prostatic tissues of both groups of rats before the treatment. The inflammation was significantly improved after the treatment in the PPS group but not in the placebo group.
  
  
  CONCLUSIONS
  PPS has some therapeutic effect on CNP in the rat, and its mechanism may be associated with the abilities of PPS to repair the damaged glycosaminoglycan layer and inhibit inflammation in the prostate.
authors.affiliation: Department of Urology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou, Gansu 730050, China. lwping1979@yahoo.com.cn
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Li
authors.forename: Yang-Min
authors.initials: YM
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Ling-Min
authors.initials: LM
authors.lastname: Song
authors.forename: Gou-Mei
authors.initials: GM
authors.lastname: Qiao
authors.forename: Xiao-Zheng
authors.initials: XZ
authors.lastname: Lü
mesh_terms: D000818:Animals; D002908:Chronic Disease; D018856:Cystitis, Interstitial / Q000188:drug therapy; D004195:Disease Models, Animal; D008297:Male; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use*; D011467:Prostate / Q000473:pathology; D011472:Prostatitis / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010426:Pentosan Sulfuric Polyester