title: Preparation and characterization of polyester- and poly(ester-carbonate)-paclitaxel conjugates.
abstract: The polyester- and poly(ester-carbonate)-paclitaxel conjugates with low molecular weight were synthesized using dicyclohexylcarbodiimide (DCC) and dimethylaminopyridine (DMAP) as catalysts. Polymeric matrices were obtained by ring-opening polymerization of ɛ-caprolactone (CL), rac-lactide (rac-LA), l-lactide (LLA) and trimethylene carbonate (TMC). The macromolecular conjugates were characterized by using spectroscopic techniques, such as (1)H, (13)C NMR and FTIR. The degree of degradation of polyester- and poly(ester-carbonate)-paclitaxel conjugates was tested in vitro under different conditions. The preliminary results of drug release were discussed.
authors.affiliation: Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland. marcin.sobczak@wp.pl
authors.forename: Marcin
authors.initials: M
authors.lastname: Sobczak
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Korzeniowska
authors.forename: Piotr
authors.initials: P
authors.lastname: Goś
authors.forename: Waclaw L
authors.initials: WL
authors.lastname: Kolodziejski
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D002208:Caproates / Q000737:chemistry; D002384:Catalysis; D003692:Delayed-Action Preparations; D004024:Dicyclohexylcarbodiimide / Q000737:chemistry; D004146:Dioxanes / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers; D065546:Drug Liberation; D007783:Lactones / Q000737:chemistry; D017239:Paclitaxel / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis*; D011725:Pyridines / Q000737:chemistry
chemical_list: C417980:4-(dimethylamine)pyridine; D000972:Antineoplastic Agents, Phytogenic; D002208:Caproates; D003692:Delayed-Action Preparations; D004146:Dioxanes; D004337:Drug Carriers; D007783:Lactones; D011091:Polyesters; D011725:Pyridines; C443643:trimethylene carbonate; D004024:Dicyclohexylcarbodiimide; C121056:caprolactone; C091880:dilactide; D017239:Paclitaxel