title: Radiotherapy of unicentric mediastinal Castleman's disease.
abstract: Castleman's disease is a slowly progressive and rare lymphoproliferative disorder. Here, we report a 55-year-old woman with superior mediastinal Castleman's disease being misdiagnosed for a long term. We found a 4.3 cm mass localized in the superior mediastinum accompanied with severe clinical symptoms. The patient underwent an exploratory laparotomy, but the mass failed to be totally excised. Pathologic examination revealed a mediastinal mass of Castleman's disease. After radiotherapy of 30 Gy by 15 fractions, the patient no longer presented previous symptoms. At 3 months after radiotherapy of 60 Gy by 30 fractions, Computed tomography of the chest showed significantly smaller mass, indicating partial remission. Upon a 10-month follow-up, the patient was alive and free of symptoms.
authors.affiliation: Cancer Center, PLA 309 Hospital, Beijing 100091, P.R. China.
authors.forename: Yue-Min
authors.initials: YM
authors.lastname: Li
authors.forename: Peng-Hui
authors.initials: PH
authors.lastname: Liu
authors.forename: Yu-Hai
authors.initials: YH
authors.lastname: Zhang
authors.forename: Huo-Sheng
authors.initials: HS
authors.lastname: Xia
authors.forename: Liang-Liang
authors.initials: LL
authors.lastname: Li
authors.forename: Yi-Mei
authors.initials: YM
authors.lastname: Qu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.forename: Shou-Yun
authors.initials: SY
authors.lastname: Han
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Liao
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Pu
mesh_terms: D018951:Antigens, CD20 / Q000378:metabolism; D005871:Castleman Disease / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008477:Mediastinal Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008482:Mediastinum / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D050397:Radiotherapy, Intensity-Modulated; D014057:Tomography, X-Ray Computed
chemical_list: D018951:Antigens, CD20