title: Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer.
abstract: K-ras activating point mutations appear to have a role in human lung cancer, however, the prognostic significance of these abnormalities remains unclear. The aim of our work was to clarify the role of K-ras mutations as prognostic indicators in patients affected by non-small cell lung cancer (NSCLC). We studied 94 resected primary NSCLCs for K-ras mutations by the PCR-RFLP technique, followed by sequencing. K-ras activating mutations were present in 34% of tumors, a higher incidence being detected in adenocarcinomas. Comparing the impact of K-ras mutation types, we found that K-ras transversions were associated with a shorter survival in NSCLC.
authors.affiliation: UNIV COMPLUTENSE MADRID,FAC FARM,DEPT BIOQUIM & BIOL MOL,E-28040 MADRID,SPAIN. UNIV HOSP,SERV IMMUNOL,MADRID 28040,SPAIN. UNIV HOSP,SERV CIRUGIA,MADRID 28040,SPAIN. UNIV HOSP,SERV ANAT PATOL,MADRID 28040,SPAIN. UNIV HOSP,SERV ONCOL,MADRID 28040,SPAIN.
authors.forename: F
authors.initials: F
authors.lastname: Vega
authors.forename: P
authors.initials: P
authors.lastname: Iniesta
authors.forename: T
authors.initials: T
authors.lastname: Caldes
authors.forename: A
authors.initials: A
authors.lastname: Sanchez
authors.forename: J
authors.initials: J
authors.lastname: Lopez
authors.forename: C
authors.initials: C
authors.lastname: Dejuan
authors.forename: E
authors.initials: E
authors.lastname: Diazrubio
authors.forename: A
authors.initials: A
authors.lastname: Torres
authors.forename: J
authors.initials: J
authors.lastname: Balibrea
authors.forename: M
authors.initials: M
authors.lastname: Benito