title: An obese body mass increases the adverse effects of HIV/AIDS on balance and gait.
abstract: BACKGROUND
  Balance and gait problems have been detected among patients with HIV/AIDS. The extent to which these problems are exacerbated by either frailty or obesity has not been examined. Objective The purpose of this study was to compare participants who differed in body mass and the presence or absence of HIV/AIDS.
  
  
  METHODS
  This was a cross-sectional study.
  
  
  METHODS
  Quantitative measurements were obtained from 86 participants who were HIV-type 1 (HIV-1) seronegative and 121 participants who were seropositive divided into subgroups based on their body mass index (BMI <21, 21-29, or >29 kg/m(2)).
  
  
  RESULTS
  Participants who were seropositive were impaired relative to seronegative controls on several indices, including the limit of stability, sway amplitude and sway strategy, gait initiation time, and gait speed during a fast pace condition. Participants who were obese also exhibited impairments, which were evident during assessments of the limit of stability, nonpreferred leg stance time, sway strategy, normal and fast gait speed, fast gait initiation time, and 360-degree turn time. Importantly, the analysis revealed that participants with both attributes were more impaired than those with either or neither attribute: patients who were obese and seropositive were more impaired in fast gait initiation time and cadence, nonpreferred leg stance time, 360-degree turn time, and sway strategy scores. Limitations The validity of BMI as a measure of body mass can be challenged. In addition, the validity of chair rise time and 360-degree turn time as estimates of lower-extremity strength (force-generating capacity) can be argued.
  
  
  CONCLUSIONS
  The present findings have an obvious and unfortunate implication: as more patients who are HIV-1 seropositive join the seronegative community in becoming obese, the effects of obesity and their disease may summate and their risk for balance and gait problems may increase.
authors.affiliation: University of Connecticut School of Medicine, 263 Farmington Ave, MC-2103, Farmington, CT 06030-2103, USA.
authors.forename: Lance O
authors.initials: LO
authors.lastname: Bauer
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wu
authors.forename: Leslie I
authors.initials: LI
authors.lastname: Wolfson
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005684:Gait / Q000502:physiology*; D015658:HIV Infections / Q000503:physiopathology*; D006679:HIV Seropositivity / Q000503:physiopathology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D004856:Postural Balance / Q000502:physiology*