title: Genotypic profile of Streptococcus suis serotype 2 and clinical features of infection in humans, Thailand.
abstract: To examine associations between clinical features of Streptococcus suis serotype 2 infections in humans in Thailand and genotypic profiles of isolates, we conducted a retrospective study during 2006-2008. Of 165 patients for whom bacterial cultures of blood, cerebrospinal fluid, or both were positive for S. suis serotype 2, the major multilocus sequence types (STs) found were ST1 (62.4%) and ST104 (25.5%); the latter is unique to Thailand. Clinical features were examined for 158 patients. Infections were sporadic; case-fatality rate for adults was 9.5%, primarily in northern Thailand. Disease incidence peaked during the rainy season. Disease was classified as meningitis (58.9%) or nonmeningitis (41.1%, and included sepsis [35.4%] and others [5.7%]). Although ST1 strains were significantly associated with the meningitis category (p<0.0001), ST104 strains were significantly associated with the nonmeningitis category (p<0.0001). The ST1 and ST104 strains are capable of causing sepsis, but only the ST1 strains commonly cause meningitis.
authors.affiliation: Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Anusak
authors.initials: A
authors.lastname: Kerdsin
authors.forename: Surang
authors.initials: S
authors.lastname: Dejsirilert
authors.forename: Parichart
authors.initials: P
authors.lastname: Puangpatra
authors.forename: Saowalak
authors.initials: S
authors.lastname: Sripakdee
authors.forename: Koranan
authors.initials: K
authors.lastname: Chumla
authors.forename: Nitsara
authors.initials: N
authors.lastname: Boonkerd
authors.forename: Pitimol
authors.initials: P
authors.lastname: Polwichai
authors.forename: Susumu
authors.initials: S
authors.lastname: Tanimura
authors.forename: Dan
authors.initials: D
authors.lastname: Takeuchi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakayama
authors.forename: Shota
authors.initials: S
authors.lastname: Nakamura
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Akeda
authors.forename: Marcelo
authors.initials: M
authors.lastname: Gottschalk
authors.forename: Pathom
authors.initials: P
authors.lastname: Sawanpanyalert
authors.forename: Kazunori
authors.initials: K
authors.lastname: Oishi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016000:Cluster Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D058885:Multilocus Sequence Typing; D058974:Phylogeography; D012189:Retrospective Studies; D012621:Seasons; D013290:Streptococcal Infections / Q000503:physiopathology*; D017011:Streptococcus suis / Q000145:classification / Q000235:genetics*; D013785:Thailand; D055815:Young Adult