title: Induction of apoptosis in head and neck tumor-cell lines by anti-fas antibody.
abstract: Programmed cell death, currently termed apoptosis plays a key role in the maintenance of the steady state in continuously renewing tissues. Since little is known of apoptosis in head and neck tumors, we studied morphological changes in head and neck tumor-derived cell lines (KB, KBrc, HSC-2,3,4), induced by anti-Fas antibody. Light and electron microscopic examinations were carried out after culturing these cell lines with the antibody for 1-2 days. The antitumor effect of anti-Fas antibody on tumor cells differed with the cell lines. Most of the cell lines that were sensitive to anti-Pas antibody showed evidence of enhanced apoptosis when the cells were pretreated with interferon-gamma. The results suggest that the strategy of induction of apoptosis by anti-Fas antibody may be considered in treatment of some tumors of head and neck.
authors.affiliation: KANSAI MED UNIV,DEPT NEUROSURG,MORIGUCHI,OSAKA 570,JAPAN. KANSAI MED UNIV,DEPT PATHOL,MORIGUCHI,OSAKA 570,JAPAN.
authors.forename: H
authors.initials: H
authors.lastname: Kumazawa
authors.forename: T
authors.initials: T
authors.lastname: Tachikawa
authors.forename: S
authors.initials: S
authors.lastname: Sai
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: K
authors.initials: K
authors.lastname: Kawamoto
authors.forename: T
authors.initials: T
authors.lastname: Oyaizu
authors.forename: A
authors.initials: A
authors.lastname: Tsubura