title: Matrix metalloproteinases: keys to healthier blood vessels in diabetes?
abstract: In this issue of Journal of Endocrinology, Schuyler et al. show that intimal lesions in atherosclerosis-prone diabetic apoE(-/-) mice are reduced by insulin treatment. An increase of metalloproteinase-9 expression was observed in untreated diabetic apoE(-/-) mice; this was absent in insulin-treated mice. The study suggests that hindering of tissue-remodeling metalloproteinases may account for the beneficial effects of proper metabolic control in patients with diabetes. This clinically relevant finding prompts further exploration.
authors.affiliation: Unit of Molecular Metabolism, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Malmö SE-205 02, Sweden. hindrik.mulder@med.lu.se
authors.forename: Hindrik
authors.initials: H
authors.lastname: Mulder
mesh_terms: D000818:Animals; D003925:Diabetic Angiopathies / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology / Q000517:prevention & control; D007328:Insulin / Q000627:therapeutic use; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D058226:Plaque, Atherosclerotic / Q000188:drug therapy / Q000378:metabolism
chemical_list: D007328:Insulin; D020782:Matrix Metalloproteinases; D020780:Matrix Metalloproteinase 9