title: Computation of hemodynamics in the left coronary artery with variable angulations.
abstract: The purpose of this study was to investigate the hemodynamic effect of variations in the angulations of the left coronary artery, based on simulated and realistic coronary artery models. Twelve models consisting of four realistic and eight simulated coronary artery geometries were generated with the inclusion of left main stem, left anterior descending and left circumflex branches. The simulated models included various coronary artery angulations, namely, 15°, 30°, 45°, 60°, 75°, 90°, 105° and 120°. The realistic coronary angulations were based on selected patient's data with angles ranging from narrow angles of 58° and 73° to wide angles of 110° and 120°. Computational fluid dynamics analysis was performed to simulate realistic physiological conditions that reflect the in vivo cardiac hemodynamics. The wall shear stress, wall shear stress gradient, velocity flow patterns and wall pressure were measured in simulated and realistic models during the cardiac cycle. Our results showed that a disturbed flow pattern was observed in models with wider angulations, and wall pressure was found to reduce when the flow changed from the left main stem to the bifurcated regions, based on simulated and realistic models. A low wall shear stress gradient was demonstrated at left bifurcations with wide angles. There is a direct correlation between coronary angulations and subsequent hemodynamic changes, based on realistic and simulated models. Further studies based on patients with different severities of coronary artery disease are required to verify our results.
authors.affiliation: Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, G.P.O Box U1987, Perth, Western Australia 6845, Australia.
authors.forename: Thanapong
authors.initials: T
authors.lastname: Chaichana
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Sun
authors.forename: James
authors.initials: J
authors.lastname: Jewkes
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D003198:Computer Simulation; D003324:Coronary Artery Disease; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000473:pathology* / Q000502:physiology*; D006439:Hemodynamics; D006801:Humans; D008953:Models, Anatomic; D015233:Models, Statistical; D008962:Models, Theoretical; D012307:Risk Factors; D033081:Shear Strength; D012984:Software; D013314:Stress, Mechanical