title: Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk.
abstract: A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: Dalemari
authors.initials: D
authors.lastname: Crowther-Swanepoel
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Di Bernardo
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jamroziak
authors.forename: Lidia
authors.initials: L
authors.lastname: Karabon
authors.forename: Irena
authors.initials: I
authors.lastname: Frydecka
authors.forename: Silvia
authors.initials: S
authors.lastname: Deaglio
authors.forename: Giovanni
authors.initials: G
authors.lastname: D'Arena
authors.forename: Davide
authors.initials: D
authors.lastname: Rossi
authors.forename: Gianluca
authors.initials: G
authors.lastname: Gaidano
authors.forename: Bianca
authors.initials: B
authors.lastname: Olver
authors.forename: Amy
authors.initials: A
authors.lastname: Lloyd
authors.forename: Peter
authors.initials: P
authors.lastname: Broderick
authors.forename: Luca
authors.initials: L
authors.lastname: Laurenti
authors.forename: Zofia
authors.initials: Z
authors.lastname: Szemraj-Rogucka
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Robak
authors.forename: Daniel
authors.initials: D
authors.lastname: Catovsky
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide