title: Zinc transporter ZnT3 is involved in memory dependent on the hippocampus and perirhinal cortex.
abstract: Since zinc transporter ZnT3 is localized to the hippocampus and perirhinal cortex, we used ZnT3 knockout mice (KO) to analyze the role of ZnT3 in memory and behavior dependent on these brain regions. ZnT3KO mice were normal in initial learning in the standard water maze but had difficulty finding a second platform location. The mutants showed increased social interaction but were deficient in social and object recognition memory. These data suggest that ZnT3 is involved in certain types of spatial memory and behavior dependent on the hippocampus and perirhinal cortex.
authors.affiliation: Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Martel
authors.forename: Charles
authors.initials: C
authors.lastname: Hevi
authors.forename: Noriko
authors.initials: N
authors.lastname: Kane-Goldsmith
authors.forename: Gleb P
authors.initials: GP
authors.lastname: Shumyatsky
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D027682:Cation Transport Proteins; D006624:Hippocampus / Q000502:physiology*; D007398:Interpersonal Relations; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D026901:Membrane Transport Proteins; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D013702:Temporal Lobe / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D027682:Cation Transport Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C491177:Slc30a3 protein, mouse