title: Establishment of a new human uterine cervical adenocarcinoma cell-line, siso, and its reactivity to anticancer reagents.
abstract: A human cell line, SiSo, was established from a patient afflicted with uterine cervical adenocarcinoma. The SiSo cell expresses MHC class I antigen, various kinds of adhesion molecules and tumor-associated antigens such as CA125, CEA and GA733. The secretion of CA125 antigen was markedly suppressed by anti-cancer reagents. However, their growth was not affected by any of the anti-cancer reagents tested, suggesting a discrepancy between inhibition of tumor growth and suppression of secretion of tumor-associated antigens after treatment with anti-cancer reagents. The SiSo cell line will provide a tool for investigation of uterine adenocarcinoma.
authors.affiliation: KYUSHU UNIV,MED INST BIOREGULAT,DEPT MOLEC IMMUNOL,HIGASHI KU,FUKUOKA 81282,JAPAN. KYUSHU UNIV,FAC MED,DEPT OBSTET & GYNECOL,FUKUOKA 81282,JAPAN. KYUSHU UNIV,FAC MED,DEPT PATHOL 2,FUKUOKA 81282,JAPAN.
authors.forename: K
authors.initials: K
authors.lastname: Sonoda
authors.forename: M
authors.initials: M
authors.lastname: Nakashima
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Amada
authors.forename: T
authors.initials: T
authors.lastname: Kamura
authors.forename: H
authors.initials: H
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Watanabe