title: Rhabdomyolysis in an HIV-infected patient with impaired renal function concomitantly treated with rosuvastatin and lopinavir/ritonavir.
abstract: The authors describe an HIV-infected patient with moderate renal failure receiving combination antiretroviral therapy. Because of dyslipidaemia he was initially treated with pravastatin but developed rhabdomyolysis after a switch to rosuvastatin. With this case we illustrate that statins as well as antiretroviral therapy are susceptible to clinical relevant drug-drug or drug-disease interactions. Knowledge of these interactions is important to provide patients with the best possible care.
authors.affiliation: Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, the Netherlands. K.deKanter@akf.umcn.nl
authors.forename: Clara T M M
authors.initials: CT
authors.lastname: de Kanter
authors.forename: Monique
authors.initials: M
authors.lastname: Keuter
authors.forename: Manon J
authors.initials: MJ
authors.lastname: van der Lee
authors.forename: Peter P
authors.initials: PP
authors.lastname: Koopmans
authors.forename: David M
authors.initials: DM
authors.lastname: Burger
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D050171:Dyslipidemias / Q000139:chemically induced / Q000188:drug therapy; D005464:Fluorobenzenes / Q000009:adverse effects* / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D061466:Lopinavir; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D011744:Pyrimidinones / Q000009:adverse effects* / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000150:complications* / Q000188:drug therapy; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000188:drug therapy*; D019438:Ritonavir / Q000009:adverse effects* / Q000627:therapeutic use; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D011744:Pyrimidinones; D013449:Sulfonamides; D061466:Lopinavir; D000068718:Rosuvastatin Calcium; D019438:Ritonavir