title: Addicted to Myc--but why?
abstract: Many tumors continuously depend on the initiating oncogenes, but whether this extends to their downstream targets is unclear. In this issue of Genes & Development, Sodir and colleagues (pp. 907-916) demonstrate an essential role for endogenous Myc proteins in maintaining the tumor microenvironment, providing an unexpected molecular explanation for addiction to Myc.
authors.affiliation: Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg 97074, Germany.
authors.forename: Björn
authors.initials: B
authors.lastname: von Eyss
authors.forename: Martin
authors.initials: M
authors.lastname: Eilers
mesh_terms: D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000378:metabolism; D017209:Apoptosis; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*; D059016:Tumor Microenvironment / Q000502:physiology
chemical_list: D000952:Antigens, Polyomavirus Transforming; D016271:Proto-Oncogene Proteins c-myc