title: Evaluating patient adherence to antidepressant therapy among uninsured working adults diagnosed with major depression: results of the Texas Demonstration to Maintain Independence and Employment study.
abstract: This study examined antidepressant adherence and persistence among uninsured working adults diagnosed with major depression enrolled in the Texas Demonstration to Maintain Independence and Employment (DMIE) program. Antidepressant adherence was measured between intervention and control cohorts using proportion of days covered (PDC) during a 365-day observation period. Persistence examined duration of time from drug initiation to discontinuation based on a ≥35-day refill supply gap. Older, non-minority patients with higher education were more adherent or persistent to antidepressant therapy. Adjusting for covariates, results showed no significant difference in PDC at the end of 12-months between intervention and control participants (b = .07, P = .054, semi-partial η (2) = .02). Exploratory analysis found subgroup differences in PDC among the study recruitment cohorts. No significant difference between intervention and control groups was found in persistence between the groups. Follow-up investigation is planned to assess the longer term impact of the DMIE program on antidepressant adherence and persistence.
authors.affiliation: Addiction Research Institute, University of Texas at Austin, 1717 West 6th Street, Suite 335, Austin, TX 78703, USA. esmondn@mail.utexas.edu
authors.forename: Esmond D
authors.initials: ED
authors.lastname: Nwokeji
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Bohman
authors.forename: Lynn
authors.initials: L
authors.lastname: Wallisch
authors.forename: Dena
authors.initials: D
authors.lastname: Stoner
authors.forename: Kristin
authors.initials: K
authors.lastname: Christensen
authors.forename: Richard R
authors.initials: RR
authors.lastname: Spence
authors.forename: Brian C
authors.initials: BC
authors.lastname: Reed
authors.forename: Britta
authors.initials: B
authors.lastname: Ostermeyer
mesh_terms: D000328:Adult; D000367:Age Factors; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D003695:Delivery of Health Care / Q000379:methods*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004522:Educational Status; D004651:Employment; D005260:Female; D006801:Humans; D008297:Male; D017057:Medically Uninsured; D008875:Middle Aged; D011203:Poverty; D013781:Texas; D016903:Drug Monitoring
chemical_list: D000928:Antidepressive Agents