title: Expression of activated HER2 in human testes.
abstract: The HER2 messenger RNA (mRNA) was the most abundant among the erb type-1 tyrosine kinase receptors mRNA in human testis and was statistically significantly decreased in impaired spermatogenesis. Testicular HER2 was tyrosine phosphorylated and strongly expressed in spermatogonia, early spermatocytes, elongating/elongated spermatids, Sertoli cells, Leydig cells, and peritubular cells, suggesting that activated HER2 participates in mitosis and meiotic entry of germ cells, spermiogenesis, and steroidogenesis via mediating the epidermal growth factor-growth factor signaling.
authors.affiliation: Department of Life Science and Institute for Natural Sciences, Hanyang University, Seoul, South Korea.
authors.forename: Inchoel
authors.initials: I
authors.lastname: Shin
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Kim
authors.forename: Won Heum
authors.initials: WH
authors.lastname: Nah
authors.forename: Hyun Jun
authors.initials: HJ
authors.lastname: Park
authors.forename: Myung Chan
authors.initials: MC
authors.lastname: Gye
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D053713:Azoospermia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D001706:Biopsy; D015153:Blotting, Western; D006801:Humans; D007150:Immunohistochemistry; D007985:Leydig Cells / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D012333:RNA, Messenger / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis* / Q000235:genetics; D056910:Republic of Korea; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012708:Sertoli Cells / Q000737:chemistry; D013087:Spermatids / Q000737:chemistry; D013090:Spermatocytes / Q000737:chemistry; D013091:Spermatogenesis; D013093:Spermatogonia / Q000737:chemistry; D013737:Testis / Q000737:chemistry* / Q000473:pathology / Q000503:physiopathology; D014443:Tyrosine
chemical_list: D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; D014443:Tyrosine; C508053:ERBB2 protein, human