title: Necrotizing soft-tissue infections.
abstract: OBJECTIVE
  To provide a contemporary review of the diagnosis and management of necrotizing soft-tissue infections.
  
  
  METHODS
  Scientific literature and internet sources.
  
  
  METHODS
  Major articles of importance in this area.
  
  
  CONCLUSIONS
  The mortality for necrotizing soft-tissue infections appears to be decreasing, possibly due to improved recognition and earlier delivery of more effective therapy. Establishing a diagnosis and initiating treatment as soon as possible provides the best opportunity for a good outcome.
authors.affiliation: Department of Surgery, Division of Trauma, Burns, and Critical Care, Case Western Reserve University, MetroHealth Medical Center Campus, Cleveland, OH, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Ustin
authors.forename: Mark A
authors.initials: MA
authors.lastname: Malangoni
mesh_terms: D000137:Acid-Base Imbalance / Q000628:therapy; D000890:Anti-Infective Agents / Q000627:therapeutic use; D003646:Debridement; D019115:Fasciitis, Necrotizing / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D005440:Fluid Therapy; D006801:Humans; D009336:Necrosis; D018461:Soft Tissue Infections / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology / Q000628:therapy
chemical_list: D000890:Anti-Infective Agents