title: Dengue antibody in Thai children from maternally transferred antibody to acquired infection.
abstract: This prospective cohort study examined serotype-specific neutralizing serum antibodies to dengue in 55 maternal-newborn pairs, at 3, 6, 9, 12, 18, and 24 months, and again at 4 to 8 years of age. In all, 95% of the mothers had neutralizing antibody to at least one dengue serotype, and 92.7% of the maternally transferred antibody had disappeared in 12-month-old infants. In all, 31 infants had serologically confirmed dengue infection; 5 symptomatic and 29 inapparent infections were reported. The increasing trend of inapparent infections among the older age group warrants further study of the need for effective dengue vaccination beyond 2 years of age.
authors.affiliation: Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. tmkps@mahidol.ac.th
authors.forename: Krisana
authors.initials: K
authors.lastname: Pengsaa
authors.forename: Kriengsak
authors.initials: K
authors.lastname: Limkittikul
authors.forename: Sutee
authors.initials: S
authors.lastname: Yoksan
authors.forename: Pataporn
authors.initials: P
authors.lastname: Wisetsing
authors.forename: Arunee
authors.initials: A
authors.lastname: Sabchareon
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003715:Dengue / Q000453:epidemiology* / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D013785:Thailand / Q000453:epidemiology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral