title: Drug trials for older people.
abstract: We are living in an era of unprecedented aging, with over a billion older people expected to be alive within a few decades. Despite this predictable demographic, drug trials have not kept pace with change and we now have significant evidence-practice gaps. These have arisen due to inappropriate age limits in randomized controlled trials and the near-universal exclusion of frail older people from studies. Suggested solutions include the abolition of age limits in new randomized controlled trials, and the routine measurement of frailty, with a new generation of randomized controlled trials to establish whether treatments remain effective and safe in old age and increasing frailty. We should all have a personal interest in ensuring that drugs used in our old age are truly effective.
authors.affiliation: George Institute for Global Health, Sydney, Australia. richard.lindley@sydney.edu.au
authors.forename: Richard I
authors.initials: RI
authors.lastname: Lindley
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000187:drug effects*; D002986:Clinical Trials as Topic; D006801:Humans