title: Advances in proteomic strategies toward the early detection of lung cancer.
abstract: Since the advent of the new proteomics era more than a decade ago, large-scale studies of protein profiling have been exploited to identify the distinctive molecular signatures in a wide array of biological systems spanning areas of basic biological research, various disease states, and biomarker discovery directed toward therapeutic applications. Recent advances in protein separation and identification techniques have significantly improved proteomics approaches, leading to enhancement of the depth and breadth of proteome coverage. Proteomic signatures specific for invasive lung cancer and preinvasive lesions have begun to emerge. In this review we provide a critical assessment of the state of recent advances in proteomic approaches and the biological lessons they have yielded, with specific emphasis on the discovery of biomarker signatures for the early detection of lung cancer.
authors.affiliation: Vanderbilt University Medical Center Vanderbilt-Ingram Cancer Center, Nashville, TN 37232-6838, USA.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hassanein
authors.forename: Jamshedur S M
authors.initials: JS
authors.lastname: Rahman
authors.forename: Pierre
authors.initials: P
authors.lastname: Chaurand
authors.forename: Pierre P
authors.initials: PP
authors.lastname: Massion
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D018450:Disease Progression; D055088:Early Detection of Cancer; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000378:metabolism*; D011230:Precancerous Conditions / Q000097:blood / Q000378:metabolism*; D040901:Proteomics; D018570:Risk Assessment; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D014408:Biomarkers, Tumor