title: Pleiotropic effects of the HMG-CoA reductase inhibitors.
abstract: The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropy of statins and emphasizes the importance of randomized placebo-controlled trials to further elucidate this interesting phenomenon.
authors.affiliation: Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL, USA.
authors.forename: Christos G
authors.initials: CG
authors.lastname: Mihos
authors.forename: Orlando
authors.initials: O
authors.lastname: Santana