title: Silica-supported boric acid with ionic liquid: a novel recyclable catalytic system for one-pot three-component Mannich reaction.
abstract: A rapid and efficient silica-supported boric acid/ionic liquid ([bmim][PF₆]), catalyzed, one-pot three-component Mannich reaction has been carried out to synthesize β-amino carbonyl compounds at room temperature. The reaction afforded desired products in excellent yields with moderate to good diastereoselectivity. The method provides a novel modification of three-component Mannich reaction in terms of mild reaction conditions, clean reaction profiles, low amount of catalyst, recyclability of catalyst and a simple workup procedure. The present report first time describes the preparation of H₃BO₃-SiO₃ catalyst and its use with [bmim][PF₆], to synthesize Mannich products. The catalyst can be reused at least seven times.
authors.affiliation: Natural Plant Products Division, Institute of Himalayan Bioresource Technology (Council of Scientific & Industrial Research), Pradesh, India.
authors.forename: Vishal
authors.initials: V
authors.lastname: Kumar
authors.forename: Upendra
authors.initials: U
authors.lastname: Sharma
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Verma
authors.forename: Neeraj
authors.initials: N
authors.lastname: Kumar
authors.forename: Bikram
authors.initials: B
authors.lastname: Singh
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000478:Alkylation; D000588:Amines / Q000737:chemistry; D001888:Boric Acids / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D008352:Mannich Bases / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D059027:Recycling / Q000379:methods*; D053838:Scattering, Small Angle; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism; D014961:X-Ray Diffraction
chemical_list: D000447:Aldehydes; D000588:Amines; D001888:Boric Acids; D007097:Imines; D052578:Ionic Liquids; D008352:Mannich Bases; D012822:Silicon Dioxide; C032688:boric acid