title: Plaque volume derived from three-dimensional reconstruction of coronary angiography predicts the fractional flow reserve.
abstract: OBJECTIVE
  To compare the data calculated from the three dimensional (3D) reconstruction of a coronary stenosis with the fractional flow reserve (FFR) values measured on the same coronary segment.
  
  
  METHODS
  Multiple projections of 22 patients (7 female, 15 male, age: 61 ± 9.73 years) were evaluated by the IC30 software of the Axiom Artis X-ray machine. 3D reconstruction was successfully carried out on 23 coronary arteries (14 LAD, 4 CX and 5 RCA).
  
  
  RESULTS
  Regression analysis demonstrated significant relationship between the cross-sectional area percentage stenosis (AS) calculated based on the 3D measurement and the FFR (r: -0.566, p: 0.008), as well as between the 3D derived plaque volume (PV) and the FFR (r: -0.501, p: 0.018). On the other hand, the diameter stenosis (DS) and the minimal lumen diameter (MLD) did not correlate with the FFR values. According to the Receiver Operating Characteristic (ROC) analysis the rank of the areas under the ROC curves (AUC) was the following: 1. PV (0.76), 2. AS (0.74), 3. DS (0.62), 4. MLA (0.55), and 5. MLD (0.51). The difference between the AUC of the PV and MLA was found to be significant (p=0.02). The best agreement with the FFR was found when the PV was >44% (sensitivity 66.67%, specificity 82.35%) and the 3D AS was >60% (sensitivity 100%, specificity 47%).
  
  
  CONCLUSIONS
  Besides the 3D AS the calculated PV characterizing the entire lesion is also an important predictor of the flow consequence of the stenosis.
authors.affiliation: Institute of Cardiology, University of Debrecen, Hungary.
authors.forename: R
authors.initials: R
authors.lastname: Kolozsvári
authors.forename: B
authors.initials: B
authors.lastname: Tar
authors.forename: P
authors.initials: P
authors.lastname: Lugosi
authors.forename: J
authors.initials: J
authors.lastname: Sánta
authors.forename: Z
authors.initials: Z
authors.lastname: Béres
authors.forename: T
authors.initials: T
authors.lastname: Ungvári
authors.forename: P
authors.initials: P
authors.lastname: Polgár
authors.forename: Zs
authors.initials: Z
authors.lastname: Kőszegi
mesh_terms: D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011857:Radiographic Image Interpretation, Computer-Assisted