title: Antitubercular chromones and flavonoids from Pisonia aculeata.
abstract: Three new chromones, pisonins A (1), B (2), and D (4), two new flavonoids, pisonivanone [(2S)-5,7,2'-trihydroxy-8-methylflavanone] (7) and pisonivanol [(2R,3R)-3,7-dihydroxy-5,6-dimethoxyflavanone] (8), one new isoflavonoid, pisonianone (5,7,2'-trihydroxy-6-methoxy-8-methylisoflavone) (9), and five compounds first isolated from nature, namely, pisonins C (3), E (5), and F (6), pisoniamide (10), and pisonolic acid (11), together with 18 known compounds have been isolated from the methanol extract of the combined stem and root of Pisonia aculeata. Among these isolates, 2, 7, 14, 16, and 19 exhibited antitubercular activities (MICs≤50.0 μg/mL) against Mycobacterium tuberculosis H37Rv in vitro.
authors.affiliation: Graduate Institute of Natural Products, Department of Biomedical Laboratory Science and Biotechnology, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
authors.forename: Ming-Chun
authors.initials: MC
authors.lastname: Wu
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Ian-Lih
authors.initials: IL
authors.lastname: Tsai
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D039281:Nyctaginaceae / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013624:Taiwan
chemical_list: D000995:Antitubercular Agents; D002867:Chromones; D005419:Flavonoids