title: Induction of cdk2 after gamma-ray irradiation is dependent on p53 status.
abstract: We show that expression of cdk2 induced after gamma-ray irradiation is dependent on the p53 status in two human glioblastoma cell lines, one bearing the wild-type p53 gene and the other the mutant gene. This result indicates that wtp53 induces the expression of not only WAF1 but also cdk2. Our results suggest that p53-dependent WAF1 induction would act to prevent gene amplification and mutation in cells which sustain DNA damage in G(1) phase and p53-dependent cdk2 induction might act to prevent aneuploidy through E2F-1-DP-1 inactivation in cells which sustain DNA damage in G(2) phase.
authors.affiliation: NARA MED UNIV,DEPT BIOL,KASHIHARA,NARA 634,JAPAN.
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Ohnishi