title: Inhibition of inflammatory mediators by neobavaisoflavone in activated RAW264.7 macrophages.
abstract: Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages.
authors.affiliation: Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Szliszka
authors.forename: Dariusz
authors.initials: D
authors.lastname: Skaba
authors.forename: Zenon P
authors.initials: ZP
authors.lastname: Czuba
authors.forename: Wojciech
authors.initials: W
authors.lastname: Krol
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002460:Cell Line; D018836:Inflammation Mediators / Q000378:metabolism*; D007529:Isoflavones / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology*; D051379:Mice
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators; D007529:Isoflavones; C549830:neobavaisoflavone