title: Fatal invasive infection with fungemia due to Microascus cirrosus after heart and lung transplantation in a patient with cystic fibrosis.
abstract: Scopulariopsis species are rarely but increasingly recognized as opportunistic pathogens in immunocompromised patients. We report on a patient suffering from cystic fibrosis who developed disseminated fungal infection due to a rare Scopulariopsis species, Microascus cirrosus, after heart and lung transplantation. Despite antifungal combination therapy with voriconazole and caspofungin, the patient died 4 weeks after transplantation. Diagnostic difficulties and optimal management of disseminated Scopulariopsis/Microascus infections are discussed.
authors.affiliation: Laboratoire de Parasitologie-Mycologie, CHU de Nantes, Nantes, France.
authors.forename: Charline
authors.initials: C
authors.lastname: Miossec
authors.forename: Florent
authors.initials: F
authors.lastname: Morio
authors.forename: Thierry
authors.initials: T
authors.lastname: Lepoivre
authors.forename: Patrice
authors.initials: P
authors.lastname: Le Pape
authors.forename: Dea
authors.initials: D
authors.lastname: Garcia-Hermoso
authors.forename: Françoise
authors.initials: F
authors.lastname: Gay-Andrieu
authors.forename: Alain
authors.initials: A
authors.lastname: Haloun
authors.forename: Michele
authors.initials: M
authors.lastname: Treilhaud
authors.forename: François
authors.initials: F
authors.lastname: Leclair
authors.forename: Michel
authors.initials: M
authors.lastname: Miegeville
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage; D001203:Ascomycota / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D000077336:Caspofungin; D003550:Cystic Fibrosis / Q000150:complications*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D054714:Echinocandins / Q000008:administration & dosage; D017809:Fatal Outcome; D016469:Fungemia / Q000175:diagnosis* / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D016027:Heart Transplantation / Q000009:adverse effects*; D006651:Histocytochemistry; D006801:Humans; D016867:Immunocompromised Host; D055666:Lipopeptides; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008853:Microscopy; D008969:Molecular Sequence Data; D009181:Mycoses / Q000175:diagnosis* / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D010994:Pleura / Q000473:pathology; D011743:Pyrimidines / Q000008:administration & dosage; D013902:Radiography, Thoracic; D017422:Sequence Analysis, DNA; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000008:administration & dosage; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole