title: Measures of body composition and risk of heart failure in the elderly: the Rotterdam study.
abstract: OBJECTIVE
  The incidence of heart failure increases with aging. Aim of the present study was to determine whether measures body composition predict incident heart failure in older adults.
  
  
  METHODS
  Prospective community-based cohort study. 5, 868 men and women aged 55 years and older participating the Rotterdam study. Measures of body mass index and waist circumference were obtained at baseline. Information on incident heart failure was obtained during follow-up. Cox regression analyses were performed to investigate the possible association between measure of body composition and incident heart failure.
  
  
  RESULTS
  During a mean follow up of 10.9 (SD ±4.4) years, 765 participants had heart failure. After adjustment for age and gender, 1-standard deviation of body mass index, waist circumference and the waist-hip ratio predicted heart failure (HR 1.25; 95% CI 1.17-1.34; HR 1.26; 95% CI 1.18-1.36; and HR 1.17; 95% CI 1.08-1.27), respectively. In age-stratified analyses, 1-standard deviation of body mass index (1.17; 95% CI 1.06- 1.29) and waist circumference (1.16; 95% CI 1.05- 1.29) were still associated with the risk of heart failure in the oldest participants, whereas the waist-hip ratio was not (1.06; 95% CI 0.945-1.18).
  
  
  CONCLUSIONS
  Although estimates decrease with age, measures of overall and central adiposity predict incident heart failure among community dwelling older adults.
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: M A W
authors.initials: MA
authors.lastname: Van Lieshout
authors.forename: G C
authors.initials: GC
authors.lastname: Verwoert
authors.forename: F U S
authors.initials: FU
authors.lastname: Mattace-Raso
authors.forename: M C
authors.initials: MC
authors.lastname: Zillikens
authors.forename: E J
authors.initials: EJ
authors.lastname: Sijbrands
authors.forename: J W
authors.initials: JW
authors.lastname: Deckers
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: J C M
authors.initials: JC
authors.lastname: Witteman
mesh_terms: D000367:Age Factors; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D055105:Waist Circumference; D049629:Waist-Hip Ratio