title: Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer.
abstract: OBJECTIVE
  To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.
  
  
  METHODS
  One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study. The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001). Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance, tumor size, depth of wall invasion, lymph node metastasis, liver metastasis, perineural invasion, and pathological stage. They were not significantly associated with age, gender, tumor location, or histological type.
  
  
  CONCLUSIONS
  Increased MMP-1 and TIMP-1 were associated with gastric cancer. Although these markers are not good markers for diagnosis, these markers show in advanced gastric cancer.
authors.affiliation: Department of General Surgery, Yuzuncu Yıl University Medical Faculty, Van 6500, Turkey. ozgurkemik@hotmail.com
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kemik
authors.forename: Ahu Sarbay
authors.initials: AS
authors.lastname: Kemik
authors.forename: Aziz
authors.initials: A
authors.lastname: Sümer
authors.forename: Ahmet Cumhur
authors.initials: AC
authors.lastname: Dulger
authors.forename: Mine
authors.initials: M
authors.lastname: Adas
authors.forename: Huseyin
authors.initials: H
authors.lastname: Begenik
authors.forename: Ismail
authors.initials: I
authors.lastname: Hasirci
authors.forename: Ozkan
authors.initials: O
authors.lastname: Yilmaz
authors.forename: Sevim
authors.initials: S
authors.lastname: Purisa
authors.forename: Erol
authors.initials: E
authors.lastname: Kisli
authors.forename: Sefa
authors.initials: S
authors.lastname: Tuzun
authors.forename: Cetin
authors.initials: C
authors.lastname: Kotan
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D018450:Disease Progression; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood* / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D019715:Tissue Inhibitor of Metalloproteinase-1; D020781:Matrix Metalloproteinase 1