title: High-dose chemotherapy with bone marrow transplantation for advanced colorectal cancer.
abstract: A chemotherapy regimen based on high doses of BCNU and mitomycin C with autologous bone marrow transplantation was used in 18 patients with advanced colorectal carcinoma. Haematological toxicity was manageable, with a short nadir for white blood cells and platelets. The response rate was 33%, with a prevalence in peritoneal lesions compared to liver or lung metastases. Extra-haematological toxicity appeared in 16% of cases: a case of veno-occlusive disease of the liver and two cases of lung impairment are discussed. Although the response rate obtained with the regimen was satisfactory, the more extensive use of high-dose chemotherapy followed by autologous bone marrow transplantation requires the identification of less toxic protocols.
authors.affiliation: UNIV ROMA LA SAPIENZA,DEPT CLIN MED,I-00185 ROME,ITALY. UNIV ROMA LA SAPIENZA,DEPT SURG PATHOL 4,I-00185 ROME,ITALY. CASILINO HOSP,ROME,ITALY. MIL HOSP ATTILIO FRIGERI,ROME,ITALY.
authors.forename: G
authors.initials: G
authors.lastname: Codaccipisanelli
authors.forename: P
authors.initials: P
authors.lastname: Seminara
authors.forename: L
authors.initials: L
authors.lastname: Gargano
authors.forename: M
authors.initials: M
authors.lastname: Accordino
authors.forename: E
authors.initials: E
authors.lastname: Sbaffi
authors.forename: V
authors.initials: V
authors.lastname: Bonaiuti
authors.forename: R
authors.initials: R
authors.lastname: Rossetti
authors.forename: F
authors.initials: F
authors.lastname: Franchi