title: PtrA is a periplasmic protein involved in Cu tolerance in Pseudomonas aeruginosa.
abstract: In this work, we demonstrate that PtrA (U. H. Ha et al., Mol. Microbiol. 54:307-320, 2004) is a periplasmic protein, specifically synthesized in the presence of copper, that is involved in the tolerance of Pseudomonas aeruginosa to copper. Our biochemical and genetic analyses challenge its role in transcriptional inhibition of the type III secretion system.
authors.affiliation: Bacterial Pathogenesis and Cellular Responses, iRTSV, CEA-Grenoble, Grenoble cedex 09, France. sylvie.elsen@cea.fr
authors.forename: Sylvie
authors.initials: S
authors.lastname: Elsen
authors.forename: Michel
authors.initials: M
authors.lastname: Ragno
authors.forename: Ina
authors.initials: I
authors.lastname: Attree
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D003300:Copper / Q000378:metabolism / Q000633:toxicity*; D024881:Drug Resistance, Bacterial; D015964:Gene Expression Regulation, Bacterial; D033903:Periplasmic Proteins / Q000235:genetics / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D033903:Periplasmic Proteins; D003300:Copper