title: Effects of sustained abdominal aorta compression on coronary perfusion pressures and restoration of spontaneous circulation during cardiopulmonary resuscitation in swine.
abstract: OBJECTIVE
  The present study was undertaken to explore whether sustained abdominal aorta compression-cardiopulmonary resuscitation (SAAC-CPR), as a means, can raise coronary perfusion pressure (CPP) as well as restoration of spontaneous circulation (ROSC) during CPR. In the present study, we hypothesised that SAAC-CPR elevates CPP during CPR and improves ROSC, without causing liver laceration.
  
  
  METHODS
  Animals were randomised into one of two groups (Standard CPR and SAAC-CPR). Ten domestic swine (22-25 kg) were anaesthetised, intubated and mechanically ventilated. Ventricular fibrillation was induced, and after 3 min of untreated ventricular fibrillation, the animals were treated with standard CPR (with simplex chest compression (SCC) and epinephrine) or SAAC-CPR (SCC with sustained abdominal aorta compression, without epinephrine). CPP and ROSC were compared.
  
  
  RESULTS
  SCC with sustained abdominal aorta compression (SCC+SAAC) significantly increased CPP in comparison with SCC during CPR (p<0.05). The increase in CPP with SCC+SAAC is equivalent to that achieved with epinephrine (p>0.05). All animals in the standard CPR and SAAC-CPR groups restored spontaneous circulation. No liver damage was found in post-mortem examinations of the swine subjects.
  
  
  CONCLUSIONS
  During CPR, non-invasive SAAC can rapidly and reversibly raise the CPP as much as can epinephrine and is especially suitable for out-of-hospital CPR.
authors.affiliation: Department of Emergency, Chinese PLA General Hospital, Beijing, China.
authors.forename: Manhong
authors.initials: M
authors.lastname: Zhou
authors.forename: Qihua
authors.initials: Q
authors.lastname: Ran
authors.forename: Yahua
authors.initials: Y
authors.lastname: Liu
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Li
authors.forename: Tongying
authors.initials: T
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
mesh_terms: D000005:Abdomen; D000818:Animals; D001012:Aorta, Abdominal / Q000502:physiology*; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D003326:Coronary Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D006336:Heart Massage / Q000379:methods*; D011312:Pressure; D011897:Random Allocation; D013552:Swine; D014693:Ventricular Fibrillation / Q000503:physiopathology* / Q000628:therapy*