title: Preparation and evaluation of glyceryl monooleate-coated hollow-bioadhesive microspheres for gastroretentive drug delivery.
abstract: The purpose of this study was to produce hollow and bioadhesive microspheres to lengthen drug retention time in the stomach. In these microspheres, ethylcellulose was used as the matrix, Eudragit EPO was employed to modulate the release rate, and glyceryl monooleate (GMO) was the bioadhesive polymer in situ. The morphological characteristics of the microspheres were defined using scanning electron microscopy. The in vitro release test showed that the release rate of drug from the microspheres was pH-dependent, and was not influenced by the GMO coating film. The prepared microspheres demonstrated strong mucoadhesive properties with good buoyancy both in vitro and in vivo. Pharmacokinetic analysis indicated that the elimination half-life time of the hollow-bioadhesive microspheres was prolonged, and that the elimination rate was decreased. In conclusion, the hollow-bioadhesive synergic drug delivery system may be advantageous in the treatment of stomach diseases.
authors.affiliation: Department of Pharmaceutics, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, China.
authors.forename: Yuanfen
authors.initials: Y
authors.lastname: Liu
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Jiabi
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000269:Adhesives / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry; D005363:Ficusin / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D005753:Gastric Mucosa / Q000378:metabolism; D005989:Glycerides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D010316:Particle Size; D017319:Photosensitizing Agents / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D011109:Polymethacrylic Acids / Q000737:chemistry*
chemical_list: D000269:Adhesives; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D005989:Glycerides; D017319:Photosensitizing Agents; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; C013517:ethyl cellulose; D002482:Cellulose; C005953:monoolein; D005363:Ficusin