title: Rearrangement of chromosomal bands-3p13-14 in 2 hamartomas of the breast.
abstract: Cytogenetic aberrations have until now not been reported in mammary hamartomas. The finding of multiple, karyotypically abnormal clones in short-term cultures from 2 such tumors supports the interpretation that these are genuinely neoplastic lesions. The deletion del (3) (p13p14) and trisomy 18, both known to occur as primary chromosome abnormalities in breast carcinoma, were among the clonal changes in one case each. Since both tumors had structural abnormalities of 3p13-14, admittedly leading to different derivative chromosomes, rearrangement of this region might represent a unifying feature in the genesis of mammary hamartomas.
authors.affiliation: UNIV LUND HOSP,DEPT CLIN GENET,S-22185 LUND,SWEDEN. UNIV LUND HOSP,DEPT CLIN PATHOL,S-22185 LUND,SWEDEN. ODENSE UNIV HOSP,DEPT PATHOL,DK-5000 ODENSE,DENMARK.
authors.forename: C
authors.initials: C
authors.lastname: Dietrich
authors.forename: N
authors.initials: N
authors.lastname: Pandis
authors.forename: G
authors.initials: G
authors.lastname: Bardi
authors.forename: I
authors.initials: I
authors.lastname: Hagerstrand
authors.forename: J
authors.initials: J
authors.lastname: Andersen
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
authors.forename: S
authors.initials: S
authors.lastname: Heim