title: IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION.
abstract: The immunosuppressive effects of FR 900506 were investigated for one month after canine kidney and liver transplantation. Eight untreated kidney recipients lived for 8 to 19 days, mean 12.1. In contrast, the one month survival of dogs given FR 900506 in daily oral doses of 0.5, 1.0, and 1.5 mg/kg was 2/6, 3/6, and 4/6 respectively. The one month survival of liver recipients was 4/5 compared to one month survival of 1/8 in historical untreated controls. There was no evidence from biochemical tests of hepatotoxicity or nephrotoxicity.
authors.affiliation: Department of Surgery, University of Pittsburgh Health Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: S
authors.initials: S
authors.lastname: Todo
authors.forename: L
authors.initials: L
authors.lastname: Makowka
authors.forename: T
authors.initials: T
authors.lastname: Starzl