title: Effect of Salvia miltiorrhiza hydrophilic extract on antioxidant enzymes in diabetic patients with chronic heart disease: a randomized controlled trial.
abstract: To investigate whether Salvia miltiorrhiza hydrophilic extract (SMHE) has the ability to ameliorate oxidative stress in diabetic patients with chronic heart disease (CHD), 62 patients with CHD were recruited. These patients were assigned randomly into two groups: (1) placebo group receiving hypoglycemic therapy; (2) treatment group receiving hypoglycemic therapy plus SMHE. The biological markers related to oxidative stress were measured to determine the effect of treatment. Thirty patients in the placebo group and 24 patients in the treatment group were followed to completion in this study. Overall, the malondialdehyde (MDA) level at day 30 in the treatment group was significantly lower than in the placebo group. However, no significant difference in the serum antioxidant enzymes activities was observed between the groups. At day 60, the serum glutathione (GSH) level, superoxide dismutase (SOD), Paraoxonase (PONase) and glutathione reductase (GSSG-R) activities increased markedly in the treatment group compared with the placebo group. There was no significant difference in the level of lipid profile between the two groups. This study indicated that SMHE clearly reduced oxidative stress in diabetic patients with CHD.
authors.affiliation: Department of Medicine, 1st Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. qwqian@zzu.edu.cn
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Qian
authors.forename: Shuhong
authors.initials: S
authors.lastname: Qian
authors.forename: Ping
authors.initials: P
authors.lastname: Fan
authors.forename: Dongxia
authors.initials: D
authors.lastname: Huo
authors.forename: Shijin
authors.initials: S
authors.lastname: Wang
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001892:Camphanes; D002908:Chronic Disease; D048909:Diabetes Complications / Q000097:blood / Q000188:drug therapy*; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005978:Glutathione / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006331:Heart Diseases / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D053723:Panax notoginseng; D008517:Phytotherapy; D018517:Plant Roots; D027561:Salvia miltiorrhiza; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001892:Camphanes; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; C000604051:danshen dripping pill; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D043303:Aryldialkylphosphatase; D005978:Glutathione