title: Successful operation for mitral regurgitation in a patient with Gilbert's syndrome.
abstract: A 72-year-old woman complaining of dyspnea on effort was diagnosed as having mitral regurgitation (MR). Asymptomatic jaundice had initially been noticed during primary school, and an examination had shown hyperbilirubinemia. After the diagnosis of constitutional jaundice, she had remained well without further examination or medical treatment. Laboratory data showed a total serum bilirubin (TB) level of 12.2 mg/dl and a direct bilirubin level of 0.6 mg/dl. Transesophageal echocardiography showed severe MR, and we replaced the mitral valve. Postoperatively, genetic analyses identified constitutional jaundice as Gilbert's syndrome with Y486D mutation. The TB level gradually decreased. Four years after operation she is doing well with moderate hyperbilirubinemia and a TB level of 5 mg/dl. She is free from heart failure.
authors.affiliation: Department of Cardiovascular Surgery, Miki City Hospital, 58-1 Kasa, Miki, Hyogo 673-0402, Japan.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Minami
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Asada
authors.forename: Kunio
authors.initials: K
authors.lastname: Gan
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Yamada
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yano
mesh_terms: D000368:Aged; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004252:DNA Mutational Analysis; D017548:Echocardiography, Transesophageal; D005260:Female; D005878:Gilbert Disease / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D009154:Mutation; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D014453:Glucuronosyltransferase; D001663:Bilirubin