title: On the relationship of ATP depletion to chemotherapeutically-induced tumor-regression.
abstract: A positive correlation was found between increasing ATP depletion and enhanced tumor-regressing activity by combining PMA, a three drug combination (PALA, MMPR+6-AN), with FUra, or Adria, or FUra+Adria. For example, at 48 h post treatment, ATP was 68% of saline controls with a 10% tumor regression rate (PMA); ATP was 55% with a 60% regression rate (PMA+FUra); ATP was 54% with an 80% regression rate (PMA+Adria); and ATP was 30% with a;100% regression rate (PMA+FUra+Adria). The results give support to the suggestion that ATP depletion may be a significant factor in the production of chemotherapeutically-induced apoptosis.
authors.affiliation: MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021. CATHOLIC MED CTR,WOODHAVEN,NY 11421.
authors.forename: J
authors.initials: J
authors.lastname: Colofiore
authors.forename: R
authors.initials: R
authors.lastname: Stolfi
authors.forename: L
authors.initials: L
authors.lastname: Nord
authors.forename: D
authors.initials: D
authors.lastname: Martin