title: Synthesis, characterization and in vitro antimicrobial evaluation of new compounds incorporating oxindole nucleus.
abstract: New compounds incorporating with the oxindole nucleus were synthesized via the reaction of substituted isatins [5-methyl-, 5-chloro- and 1-hydroxymethyl isatins] with different nucleophiles. The structures of the newly compounds were elucidated on the basis of FTIR, (1)H NMR, (13)CMR spectral data, GC/MS and chemical analysis. Investigation of antimicrobial activity of the new compounds was evaluated using broth dilution technique in terms of minimal inhibitory concentration (MIC) count against four pathogenic bacteria and two pathogenic fungi. Most of the new compounds are significantly active against bacteria and fungi. MIC showed that compound (4a) possesses higher effect on Gram-positive bacteria Bacillus cereus than the selected antibacterial agent sulphamethoxazole, whereas compound (11c) possesses more activity against Gram-negative bacteria Shigella dysenterie.
authors.affiliation: Chemistry Department, Faculty of Women, Ain Shams University, Heliopolis, Cairo, Egypt. nadiaghk@yahoo.com
authors.forename: Nadia G
authors.initials: NG
authors.lastname: Kandile
authors.forename: Howida T
authors.initials: HT
authors.lastname: Zaky
authors.forename: Mansoura I
authors.initials: MI
authors.lastname: Mohamed
authors.forename: Hind M
authors.initials: HM
authors.lastname: Ismaeel
authors.forename: Nashwa A
authors.initials: NA
authors.lastname: Ahmed
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects*; D007211:Indoles / Q000737:chemistry*; D007510:Isatin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D000078183:Oxindoles; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D007510:Isatin