title: Tau regulates the subcellular localization of calmodulin.
abstract: Lack of tau expression in neuronal cells results in a change in the expression of few genes. However, little is known about how tau regulates gene expression. Here we show that the presence of tau could alter the subcellular localization of calmodulin, a protein that could be located at the cytoplasm or in the nucleus. Nuclear calmodulin binds to co-transcription factors, regulating the expression of genes like calbindin. In this work, we have found that in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau and that an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin.
authors.affiliation: Centro de Biología Molecular Severo Ochoa, CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Elena Gómez de
authors.initials: EG
authors.lastname: Barreda
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
mesh_terms: D000818:Animals; D064026:Calbindins; D002147:Calmodulin / Q000378:metabolism*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D009474:Neurons / Q000378:metabolism*; D064030:S100 Calcium Binding Protein G / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D064026:Calbindins; D002147:Calmodulin; C558298:Mapt protein, mouse; D064030:S100 Calcium Binding Protein G; D016875:tau Proteins