title: The Helicobacter pylori Ferric Uptake Regulator (Fur) is essential for growth under sodium chloride stress.
abstract: Epidemiological data and animal models indicate that Helicobacter pylori and dietary NaCl have a synergistic ill effect on gastric maladies. Here we show that the Ferric Uptake Regulator (Fur), which is a crucial regulatory factor required for H. pylori colonization, is essential for growth in the presence of high NaCl concentrations. Moreover, we demonstrate that the transcriptional response induced by sodium chloride stress exhibits similarities to that seen under iron depletion.
authors.affiliation: Department of Microbiology and Immunology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.
authors.forename: Hanan
authors.initials: H
authors.lastname: Gancz
authors.forename: D Scott
authors.initials: DS
authors.lastname: Merrell
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling; D055786:Gene Knockout Techniques; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development*; D009997:Osmotic Pressure; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D012965:Sodium Chloride / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D012097:Repressor Proteins; C068477:ferric uptake regulating proteins, bacterial; D012965:Sodium Chloride