title: Well-differentiated liposarcoma, an atypical lipomatous tumor, of the mesentery: a case report and review of the literature.
abstract: Mesenteric liposarcoma is a rare neoplasm. Here, we report the case of a 73-year-old Japanese man with a well-differentiated (WD) liposarcoma of the mesentery. Due to rapid growth of the abdominal mass and abdominal insufficiency, a tumorectomy was performed. The excised tumor was 12.4 × 9.6 cm in size and weighed 548 g. Cut sections showed a lobulated yellow and/or grayish-colored appearance. The histological features were predominantly those of the sclerotic and lipoma-like variants of WD liposarcoma. The cytoplasm of most spindle cells was diffusely immunoreactive for CD34, while fat cells were positive for S-100 protein. Some spindle cell nuclei were positive for CDK4, and a few were positive for MDM2. The average Ki-67 proliferation index in tumor cells was 10%, and androgen receptor expression was detected in tumor cell nuclei. The present case and 11 cases identified from a literature search were reviewed. The WD mesenteric liposarcomas developed in patients in the fourth to seventh decades of life (mean age 57.9 years). The patients consisted of 7 men and 5 women. All tumors were larger than 10 cm in diameter at the time of surgery. Complete resection might be the only curative therapy for WD liposarcomas of the mesentery, but long-term follow-up is needed because of the possibility of a local recurrence of the tumor.
authors.affiliation: Department of Pathology II, Kansai Medical University, Takii Hospital, Moriguchi, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yuri
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miyaso
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kitade
authors.forename: Kosho
authors.initials: K
authors.lastname: Takasu
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Shikata
authors.forename: Hideho
authors.initials: H
authors.lastname: Takada
authors.forename: Airo
authors.initials: A
authors.lastname: Tsubura