title: Dose intensification by the simultaneous use of rhg-csf and anticancer chemotherapy.
abstract: We have studied the simultaneous administration of rhG-CSF with doxorubicin, the latter given by continuous infusion either intra-arterially or intravenously, in a group of patients with various sarcomas. This has enabled us to substantially increase the dosage intensity of doxorubicin with a marked decrease in both hematologic and oral toxicity. While the data concerning anti-tumor activity is preliminary we believe that this combination has been responsible for a substantial increase in the effectiveness of doxorubicin in controlling the sarcomas. No adverse effect from combining doxorubicin given by infusion with rhG-CSF has been noted to date.
authors.affiliation: THOMAS JEFFERSON UNIV HOSP,DEPT ORTHOPED SURG,PHILADELPHIA,PA 19107.
authors.forename: A
authors.initials: A
authors.lastname: Weiss
authors.forename: R
authors.initials: R
authors.lastname: Lackman