title: Evaluation of myocardial protection in off-pump vs. on-pump coronary bypass surgery by troponin I estimation.
abstract: BACKGROUND
  This prospective non-randomized clinical study was done to compare Off-pump and On-pump myocardial revascularization by Troponin I release in patients undergoing first elective coronary artery bypass graft used to evaluate myocardial injury.
  
  
  METHODS
  One hundred an twenty patients were non-randomly assigned to a Off-pump or On-pump myocardial revascularization group. Cardiac Troponin I (CTnI) were measured in serial venous blood samples drawn preoperatively in both groups. In On-pump group after aortic unclamping at 12 and 24 hours and in Off-pump group after the last distal anastomosis at 12 and 24 hours.
  
  
  RESULTS
  The total amount of CTnI release were significantly higher in On-pump group than in Off-pump group. In On-pump group it was 2.1 +/- 1.9 (mean +/- SD) ng/ml vs in Off-pump group it was 1.0 +/- 1.7 (mean +/- SD) ng/ml at 12 hours and in On-pump group it was 1.6 +/- 1.6 (mean +/- SD) ng/ml vs. in Off-pump group it was .9 +/- 1.6 (mean +/- SD) ng/ml at 24 hours (P < 0.0001 for the pattern).
  
  
  CONCLUSIONS
  The lower release of CTnI in the Off-pump myocardial revascularization group indicates that the arrested heart coronary revascularization group causes more damage to the heart due to cardiopulmonary bypass than Off-pump myocardial revascularization group.
authors.affiliation: Dept. of Cardiac Surgery, National Institute of Cardiovascular Diseases, Dhaka. badruzzaman2008@gmail.com
authors.forename: Md
authors.initials: M
authors.lastname: Badruzzaman
authors.forename: Aslam
authors.initials: A
authors.lastname: Hossain
authors.forename: Asit Baran
authors.initials: AB
authors.lastname: Adhikary
authors.forename: S A
authors.initials: SA
authors.lastname: Quader
authors.forename: Sarwar
authors.initials: S
authors.lastname: Kamal
authors.forename: Sanjoy Kumar
authors.initials: SK
authors.lastname: Saha
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I