title: The effects of thymoquinone and green tea extract on wi-38 fibroblasts exposed to low-density lipoprotein - biomed 2011.
abstract: Previous research in cardiovascular disease (CVD) has indicated that differences exist among men and women. These differences are partially attributed to sex hormones, especially testosterone and estrogen. As CVD remains the leading cause of death for both men and women in the US and as healthcare costs continue to rise, researchers are seeking alternative methods of treating the disease. Consequently, the use of antioxidants for treatment of CVD has gained much attention in recent years. The specific aim of this study is to investigate the effects of the potential antioxidants thymoquinone and green tea extract on WI-38 (female) fibroblasts exposed to low-density lipoprotein (LDL). WI-38 fibroblasts were incubated with LDL in the presence of thymoquinone and/or green tea extract and were evaluated for signs of cellular damage. Results of this study suggest that thymoquinone and green tea extract may delay the progression of cellular damage caused by LDL challenge.
authors.affiliation: University of Mississippi Medical Center, Jackson, Mississippi.
authors.forename: Felicia
authors.initials: F
authors.lastname: Tardy
authors.forename: Hamed
authors.initials: H
authors.lastname: Benghuzzi
authors.forename: Michelle
authors.initials: M
authors.lastname: Tucci