title: Stress increases VCAM-1 expression at the fetomaternal interface in an abortion-prone mouse model.
abstract: Sound stress exposure increases fetal loss via inflammatory pathways. Inflammation is known to up-regulate cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), which mediates the adhesion of leukocytes to the vascular endothelium. In this work, we studied the frequency of VCAM-1(+) vessels at the fetomaternal interface in stressed and non-stressed pregnant CBA/J female mice mated with DBA/2J (high fetal loss model) or BALB/c (low fetal loss model) males. The high fetal loss model had fewer large vessels on gestation day 6.5, and stress reduced the frequency of large vessels to a similar number in both high and low fetal loss models. In the high fetal loss model, however, the frequency of VCAM-1+ vessels was dramatically increased. This study shows that VCAM-1 expression is modulated by stress at the fetomaternal interface in abortion-prone cross-breeding.
authors.affiliation: GlycoImmunoBiology Laboratory, Instituto de Investigaciones Cardiológicas Prof. Dr. Alberto C. Taquini (ININCA), CONICET - Universidad de Buenos Aires, Marcelo T. de Alvear 2270 2°, Ciudad Autónoma de Buenos Aires C1122AAJ, Argentina.
authors.forename: M B
authors.initials: MB
authors.lastname: Prados
authors.forename: M E
authors.initials: ME
authors.lastname: Solano
authors.forename: A
authors.initials: A
authors.lastname: Friebe
authors.forename: S
authors.initials: S
authors.lastname: Blois
authors.forename: P
authors.initials: P
authors.lastname: Arck
authors.forename: S
authors.initials: S
authors.lastname: Miranda
mesh_terms: D000022:Abortion, Spontaneous / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D005260:Female; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D013312:Stress, Physiological; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis*
chemical_list: D019010:Vascular Cell Adhesion Molecule-1