title: The role of placental homeobox genes in human fetal growth restriction.
abstract: Fetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. One of the key causes of adverse pregnancy outcome is fetal growth restriction (FGR). While a number of maternal, fetal, and environmental factors are known causes of FGR, the majority of FGR cases remain idiopathic. These idiopathic FGR pregnancies are frequently associated with placental insufficiency, possibly as a result of placental maldevelopment. Understanding the molecular mechanisms of abnormal placental development in idiopathic FGR is, therefore, of increasing importance. Here, we review our understanding of transcriptional control of normal placental development and abnormal placental development associated with human idiopathic FGR. We also assess the potential for understanding transcriptional control as a means for revealing new molecular targets for the detection, diagnosis, and clinical management of idiopathic FGR.
authors.affiliation: Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Victoria 3010, Australia; Pregnancy Research Centre, Department of Perinatal Medicine, Royal Women's Hospital, Parkville, Victoria 3052, Australia. padma@unimelb.edu.au
authors.forename: Padma
authors.initials: P
authors.lastname: Murthi
authors.forename: Gayathri
authors.initials: G
authors.lastname: Rajaraman
authors.forename: Shaun Patrick
authors.initials: SP
authors.lastname: Brennecke
authors.forename: Bill
authors.initials: B
authors.lastname: Kalionis
mesh_terms: D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D010920:Placenta / Q000473:pathology / Q000503:physiopathology*; D010927:Placental Insufficiency / Q000235:genetics*; D011247:Pregnancy; D014158:Transcription, Genetic
chemical_list: D018398:Homeodomain Proteins