title: Beta-lactam antibiotic decreases acquisition of and motivation to respond for cocaine, but not sweet food, in C57Bl/6 mice.
abstract: No medication is approved to treat cocaine addiction, but mounting evidence suggests that glutamate-directed approaches may reduce cocaine dependence and relapse. We tested the hypotheses that the glutamate transporter subtype 1 activator, ceftriaxone, disrupts acquisition of cocaine self-administration, motivation to self-administer cocaine, and conditioned place preference in mice. Repeated ceftriaxone (200 mg/kg) reduced the ability of mice to acquire cocaine and the motivation to self-administer cocaine after successful acquisition without affecting acquisition of or motivation for sweet food. Repeated ceftriaxone had no effect on cocaine-conditioned place preference. These results suggest that a β-lactam antibiotic reduces the direct reinforcing strength of cocaine without producing nonspecific deficits in conditioned learning processes.
authors.affiliation: Department of Pharmaceutical Sciences, Temple University Health Sciences Center, Philadelphia, Pennsylvania, USA.
authors.forename: Sara Jane
authors.initials: SJ
authors.lastname: Ward
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Rasmussen
authors.forename: Gladys
authors.initials: G
authors.lastname: Corley
authors.forename: Craig
authors.initials: C
authors.lastname: Henry
authors.forename: Jae K
authors.initials: JK
authors.lastname: Kim
authors.forename: Ellen A
authors.initials: EA
authors.lastname: Walker
authors.forename: Scott M
authors.initials: SM
authors.lastname: Rawls
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000523:psychology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D027342:Excitatory Amino Acid Transporter 2 / Q000378:metabolism; D005502:Food; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009042:Motivation / Q000187:drug effects*; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology; D012201:Reward; D012646:Self Administration; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D027342:Excitatory Amino Acid Transporter 2; C493396:Slc1a2 protein, mouse; D047090:beta-Lactams; D002443:Ceftriaxone; D003042:Cocaine