title: Primary Sjögren's syndrome with minimal change disease--a case report.
abstract: Glomerular involvement in patients with primary Sjögren's syndrome (pSS) has rarely been reported. Among them, membranoproliferative glomerulonephritis and membranous nephropathy are the more common types. We report a middle-aged female presenting concurrently with nephrotic syndrome and microscopic hematuria, and her pSS was diagnosed by positive anti-Ro (SSA)/anti-La (SSB) autoantibodies, dry mouth, severely diffuse impaired function of both bilateral parotid and submandibular glands, and a positive Schirmer test. Renal pathology revealed minimal change disease and thin basement membrane nephropathy. The patient's nephrotic syndrome resolved after treatment with corticosteroids. To our knowledge, this is the first report of minimal change disease in a patient with pSS.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Mei-Li
authors.initials: ML
authors.lastname: Yang
authors.forename: Mei-Chuan
authors.initials: MC
authors.lastname: Kuo
authors.forename: Tsan-Teng
authors.initials: TT
authors.lastname: Ou
authors.forename: Hung-Chun
authors.initials: HC
authors.lastname: Chen
mesh_terms: D000328:Adult; D004487:Edema / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006417:Hematuria / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D007684:Kidney Tubules / Q000473:pathology / Q000648:ultrastructure; D007866:Leg / Q000473:pathology; D009402:Nephrosis, Lipoid / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D011507:Proteinuria / Q000175:diagnosis / Q000209:etiology; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology
chemical_list: D005938:Glucocorticoids