title: A case of drug-induced hepatic injury associated with sitagliptin.
abstract: A 58-year-old man with a 10-year history of type II diabetes mellitus presented with progressive jaundice that began three days before admission. Thorough history-taking revealed that the patient had started on a new medication, sitagliptin, one month previously for the treatment of diabetes mellitus. Laboratory investigations showed severe liver dysfunction. Ultrasonography detected no extrahepatic biliary duct dilatation or gallstones. Abdominal computed tomography excluded pancreatic and hepatic focal lesions. Liver function improved upon discontinuation of sitagliptin. Drugs are an important, often unrecognized, cause of acute liver injury. This report presents a rare case in which sitagliptin was responsible for acute hepatic damage. As demonstrated, a thorough drug history is helpful in any case of unexplained liver injury.
authors.affiliation: Department of Internal Medicine, Kitasato Medical Center Hospital, Kitasato University, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Toyoda-Akui
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yokomori
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kaneko
authors.forename: Yuki
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Hajime
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Kumiko
authors.initials: K
authors.lastname: Tahara
authors.forename: Tadashi
authors.initials: T
authors.lastname: Motoori
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohbu
authors.forename: Masaya
authors.initials: M
authors.lastname: Oda
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000009:adverse effects*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007565:Jaundice / Q000209:etiology; D008099:Liver / Q000473:pathology; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D011719:Pyrazines / Q000009:adverse effects*; D000068900:Sitagliptin Phosphate; D014230:Triazoles / Q000009:adverse effects*
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D007004:Hypoglycemic Agents; D011719:Pyrazines; D014230:Triazoles; D000068900:Sitagliptin Phosphate