title: Neuroanatomical phenotype of Klinefelter syndrome in childhood: a voxel-based morphometry study.
abstract: Klinefelter syndrome (KS) is a genetic disorder characterized by a supernumerary X chromosome. As such, KS offers a naturally occurring human model for the study of both X-chromosome gene expression and androgen on brain development. Previous neuroimaging studies have revealed neuroanatomical variations associated with KS, but have differed widely with respect to subject inclusion criteria, including mosaicism, pubertal status, and history of testosterone replacement therapy (TRT), all factors likely to influence neurodevelopment. We conducted a voxel-based morphometry study of regional gray and white matter (GM and WM, respectively) volumes in 31 KS males (mean age, 9.69 ± 1.70 years) and 36 typically developing (TD) male controls (10.99 ± 1.72 years). None of the participants with KS had received TRT, and all were prepubertal and had nonmosaic 47,XXY karyotypes. After controlling for age, males with KS showed trends (0.05 < p < 0.10) for significantly reduced total gray matter volume (TGMV) and total white matter volume (TWMV), relative to TD males. After controlling for TGMV and age, the KS group had significantly increased sensorimotor and parietal-occipital GM and significantly reduced amygdalar, hippocampal, insular, temporal, and inferior frontal GM relative to TD controls. After controlling for TWMV and age, the KS group had significantly increased left parietal WM as well as significantly reduced frontal and temporal WM. These findings are indicative of a characteristic prepubertal neuroanatomical phenotype that may be associated with cognitive-behavioral features of KS. This work offers new insight into the relationships among X-chromosome gene expression, neuroanatomy, and cognitive-behavioral functions impaired in KS, including language and attention.
authors.affiliation: Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305-5795, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Bryant
authors.forename: Fumiko
authors.initials: F
authors.lastname: Hoeft
authors.forename: Song
authors.initials: S
authors.lastname: Lai
authors.forename: John
authors.initials: J
authors.lastname: Lackey
authors.forename: David
authors.initials: D
authors.lastname: Roeltgen
authors.forename: Judith
authors.initials: J
authors.lastname: Ross
authors.forename: Allan L
authors.initials: AL
authors.lastname: Reiss
mesh_terms: D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D002648:Child; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007713:Klinefelter Syndrome / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D009929:Organ Size