title: A web of interactions at the ends.
abstract: The synthesis of telomeric DNA by telomerase entails repeated cycles of reverse transcription on a short RNA template. In this issue of Molecular Cell, Robart and Collins (2011) describe a set of interactions between human telomerase RNA, protein domains, and the substrate DNA that drives the intricate reaction cycle.
authors.affiliation: Department of Microbiology and Immunology, W.R. Hearst Microbiology Research Center, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA. nflue@med.cornell.edu
authors.forename: Neal F
authors.initials: NF
authors.lastname: Lue
authors.forename: Min
authors.initials: M
authors.lastname: Hsu