title: STAT signaling in Dictyostelium development.
abstract: Signal transducers and activators of transcription (STAT) proteins are one of the important mediators of phosphotyrosine-regulated signaling in metazoan cells. These proteins are components of JAK/STAT signal transduction pathways, which regulate immune responses, cell fate, proliferation, cell migration, and programmed cell death in multicellular organisms. The cellular slime mould, Dictyostelium discoideum, is the simplest multicellular organism using molecules homologous to STATs, Dd-STATa-d. The Dd-STATa null mutant displays delayed aggregation, no phototaxis and fails culmination. Here, the functions of Dictyostelium STATs during development and their associated signaling molecules are discussed.
authors.affiliation: Department of Biology, Faculty of Science, Toho University, Funabashi 274-8510, Japan. tkawata@bio.sci.toho-u.ac.jp
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kawata
mesh_terms: D004023:Dictyostelium / Q000235:genetics* / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D050791:STAT Transcription Factors