title: Treatment of pharmaceuticals and diagnostic agents using zero-valent iron--kinetic studies and assessment of transformation products assay.
abstract: This research examined whether treatment with zero-valent iron in the presence of oxygen is a suitable process for the degradation of pharmaceuticals (antibiotics, cytostatic drugs) and diagnostic agents. It was shown that the concentration of all selected compounds was decreased efficiently by treatment with iron. The compounds exhibited a pseudo-first-order decay with a linear dependence on ln(c/c(0)) on time. The observed reaction rate strongly depended on pH, the amount of added iron, and the stirring speed. The influence of temperature on the reaction rate was small. Comparison of detected transformation products with those obtained after catalytic hydrogenation and treatment with Fenton's reagent revealed that reductive and oxidative processes are responsible for the transformations observed.
authors.affiliation: Technische Universität Berlin, Fachgebiet Wasserreinhaltung, Sekr. KF4, Strasse des 17. Juni 135, 10623 Berlin, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Stieber
authors.forename: Anke
authors.initials: A
authors.lastname: Putschew
authors.forename: Martin
authors.initials: M
authors.lastname: Jekel
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D006801:Humans; D007501:Iron / Q000737:chemistry*; D007700:Kinetics; D010100:Oxygen / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003287:Contrast Media; D014874:Water Pollutants, Chemical; D007501:Iron; D010100:Oxygen