title: Interictal cortical reorganization in episodic migraine without aura: an event-related fMRI study during parametric trigeminal nociceptive stimulation.
abstract: The aim of our study was to explore the pain processing network in patients with migraine during trigeminal nociceptive stimulation. Sixteen patients with episodic migraine without aura and 16 healthy controls performed functional magnetic resonance imaging during thermal stimuli (at 41, 51 and 53°C). Patients with migraine showed a greater activation in the perigenual part of anterior cingulate cortex at 51°C and less activation in the bilateral somatosensory cortex at 53°C compared to healthy controls. There were no differences in experimental pain perception between groups. Our findings demonstrate a functional reorganization of cerebral areas known to be involved in pain processing in patients with migraine.
authors.affiliation: Department of Neurological Sciences, Second University of Naples, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tessitore
authors.forename: A
authors.initials: A
authors.lastname: Russo
authors.forename: F
authors.initials: F
authors.lastname: Esposito
authors.forename: A
authors.initials: A
authors.lastname: Giordano
authors.forename: G
authors.initials: G
authors.lastname: Taglialatela
authors.forename: R
authors.initials: R
authors.lastname: De Micco
authors.forename: M
authors.initials: M
authors.lastname: Cirillo
authors.forename: F
authors.initials: F
authors.lastname: Conte
authors.forename: F
authors.initials: F
authors.lastname: d'Onofrio
authors.forename: S
authors.initials: S
authors.lastname: Cirillo
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Tedeschi
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020326:Migraine without Aura / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology*; D010146:Pain / Q000503:physiopathology*; D058748:Pain Perception / Q000502:physiology; D014276:Trigeminal Nerve / Q000502:physiology