title: [The role of ethanol in pathogenesis of pancreatitis].
abstract: Alcohol consumption is associated with pancreatitis, but the mechanism inducing this injury is not fully understood. The pancreas can metabolize ethanol via oxidative pathway involving alcohol dehydrogenase (ADH), cytochrome P-450 2E1 and the nonoxidative pathway. Injury to the pancreas due to its capacity to metabolize ethanol may be mediated by direct effects of both fatty acid ethyl esters (FAEEs) and acetaldehyde and by alterations induced within the cells during ethanol metabolism, such as changes in the intracellular redox state and the generation of oxidative stress. These processes induce changes in pancreatic digestive enzymes secretion, what contributes to development of pancreatitis.
authors.affiliation: Uniwersytet Medyczny w Białymstoku, Zakład Diagnostyki Biochemicznej.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Jelski
authors.forename: Emilia
authors.initials: E
authors.lastname: Kutyłowska
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism; D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000818:Animals; D000431:Ethanol / Q000009:adverse effects* / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D019512:Pancreatitis, Alcoholic / Q000209:etiology* / Q000378:metabolism*
chemical_list: D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000079:Acetaldehyde