title: Characterization and diagnostic confidence of contrast-enhanced ultrasound for solid renal tumors.
abstract: The objective was to determine whether contrast-enhanced ultrasound (CEUS) could improve the diagnostic confidence of solid renal masses. CEUS examinations were performed on 51 patients with renal tumors. Histologic findings from surgical specimens (n = 24) or magnetic resonance imaging follow-up (n = 27) were used as reference procedures for definitive diagnosis. Diffuse heterogeneous/homogeneous enhancement and quick peripheralnodularenhancement were found to be characteristic patterns in renal cell carcinoma (RCC). Dotlike or diffuse heterogeneous/homogeneous enhancement and slow peripheral nodular enhancement were observed as typical enhancement patterns in angiomyolipoma. The results show that CEUS combined with conventional ultrasound significantly improves diagnostic confidence. The sensitivity for RCC diagnosis with this imaging approach was 86% and the specificity was 93%. Both positive and negative predictive values of detection were 90% and the overall accuracy was 90%.
authors.affiliation: West China Hospital, Ultrasound Department, Chengdu, Sichuan, P. R China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Yan
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.forename: Yu-Lan
authors.initials: YL
authors.lastname: Peng
authors.forename: Shyam Sundar
authors.initials: SS
authors.lastname: Parajuly
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Wen
authors.forename: Di-Ming
authors.initials: DM
authors.lastname: Cai
authors.forename: Yong-Zhong
authors.initials: YZ
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D018207:Angiomyolipoma / Q000000981:diagnostic imaging*; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging*; D003287:Contrast Media; D003937:Diagnosis, Differential; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D014463:Ultrasonography / Q000379:methods*
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride