title: The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity.
abstract: This study was designed to investigate the qualitative and quantitative changes in brain tissue following aluminum chloride (AlCl(3)) administration and to determine whether boric acid (BA) has a protective effect against brain damage induced by AlCl( 3). For this aim, Sprague-Dawley rats were randomly separated into eight groups: (1) control, (2) AlCl(3) (5 mg/kg/day), (3, 4 and 5) BA (3.25, 36 and 58.5 mg/kg/day), (6, 7 and 8) AlCl(3) (5 mg/kg/day) plus BA (3.25, 36 and 58.5 mg/kg/day). After the animals were killed, the total numbers of neuron in the brain of all groups were determined using an unbiased stereological analysis. In addition to the stereological analysis, all brains were examined histopathologically by using light and electron microscopy. The stereological and histopathological results indicated a high damage of the rat brain tissues in the AlCl(3) and AlCl(3) + high dose BA (36 and 58.5) treatment groups. However, protective effects on neuron were observed in the AlCl(3) + low dose BA (3.25) group when compared other AlCl(3) groups. Our stereological and histopathological findings show that low-dose BA, as a proteasome inhibitor, can decrease the adverse effects of AlCl(3) on the cerebral cortex.
authors.affiliation: Department of Biology, Ataturk University Faculty of Science, Erzurum, Turkey. suatcolak@yahoo.com
authors.forename: Suat
authors.initials: S
authors.lastname: Colak
authors.forename: Fatime
authors.initials: F
authors.lastname: Geyikoglu
authors.forename: Osman Nuri
authors.initials: ON
authors.lastname: Keles
authors.forename: Hasan
authors.initials: H
authors.lastname: Türkez
authors.forename: Ahmet
authors.initials: A
authors.lastname: Topal
authors.forename: Bünyami
authors.initials: B
authors.lastname: Unal
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D001888:Boric Acids / Q000494:pharmacology*; D001927:Brain Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology; D002712:Chlorides / Q000633:toxicity*; D015853:Cysteine Proteinase Inhibitors; D004305:Dose-Response Relationship, Drug; D006651:Histocytochemistry; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D017607:Aluminum Compounds; D001888:Boric Acids; D002712:Chlorides; D015853:Cysteine Proteinase Inhibitors; D018696:Neuroprotective Agents; D000077410:Aluminum Chloride; C032688:boric acid