title: L-selectin--a dynamic regulator of leukocyte migration.
abstract: The leukocytic cell adhesion receptor L-selectin mediates the initial step of the adhesion cascade, the capture and rolling of leukocytes on endothelial cells. This event enables leukocytes to migrate out of the vasculature into surrounding tissues during inflammation and immune surveillance. Distinct domains of L-selectin contribute to proper leukocyte migration. In this review, we discuss the contributions of these domains with respect to L-selectin function: the regulation by serine phosphorylation of the cytoplasmic tail, the role of the transmembrane domain in receptor positioning on the cell surface as well as the N-glycosylation of the extracellular part and the identification of novel binding partners.
authors.affiliation: Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Wedepohl
authors.forename: Figen
authors.initials: F
authors.lastname: Beceren-Braun
authors.forename: Sebastian
authors.initials: S
authors.lastname: Riese
authors.forename: Konrad
authors.initials: K
authors.lastname: Buscher
authors.forename: Sven
authors.initials: S
authors.lastname: Enders
authors.forename: Gesche
authors.initials: G
authors.lastname: Bernhard
authors.forename: Karin
authors.initials: K
authors.lastname: Kilian
authors.forename: Véronique
authors.initials: V
authors.lastname: Blanchard
authors.forename: Jens
authors.initials: J
authors.lastname: Dernedde
authors.forename: Rudolf
authors.initials: R
authors.lastname: Tauber
mesh_terms: D002465:Cell Movement / Q000235:genetics / Q000502:physiology*; D006801:Humans; D018836:Inflammation Mediators / Q000737:chemistry / Q000502:physiology; D019041:L-Selectin / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D007962:Leukocytes / Q000166:cytology* / Q000473:pathology / Q000502:physiology*; D015166:Monitoring, Immunologic / Q000379:methods; D011499:Protein Processing, Post-Translational / Q000235:genetics / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology
chemical_list: D018836:Inflammation Mediators; D019041:L-Selectin