title: Diastereoselectively switchable enantioselective trapping of carbamate ammonium ylides with imines.
abstract: The diastereoselectively switchable enantioselective trapping of protic carbamate ammonium ylides with imines is reported. The intriguing Rh(2)(OAc)(4) and chiral Brønsted acid cocatalyzed three-component Mannich-type reaction of a diazo compound, a carbamate, and an imine provides rapid and efficient access to both syn- and anti-α-substituted α,β-diamino acid derivatives with a high level control of chemo-, diastereo-, and enantioselectivity.
authors.affiliation: Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Xu
authors.forename: Jian-Bei
authors.initials: JB
authors.lastname: Xi
authors.forename: Bai-Yan
authors.initials: BY
authors.lastname: Ren
authors.forename: Feng-Ping
authors.initials: FP
authors.lastname: Lv
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Jiang
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Hu
mesh_terms: D002219:Carbamates / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002219:Carbamates; D007097:Imines; D010756:Phosphoric Acids; D000644:Quaternary Ammonium Compounds; D012238:Rhodium; C030242:phosphoric acid