title: Clinical validation of the EORTC QLQ-OG25 questionnaire for the evaluation of health-related quality of life in Mexican patients with esophagogastric cancers.
abstract: BACKGROUND
  Quality of life questionnaires (QLQ) QLQ-STO22 and QLQ-OES18 are currently available to measure Health-related quality of life (HRQL) in patients with Esophageal (EC) or Gastric cancer (GC). The QLQ-OG25 integrates questions from both questionnaires to be useful for EC, Esophagogastric junction carcinoma (EGJC), and GC. Our aim was to validate the Mexican-Spanish version.
  
  
  METHODS
  The translation procedure followed European Organization for Research and Treatment of Cancer (EORTC) guidelines. QLQ-C30 and QLQ-OG25 instruments were completed by patients with EC, EGJC, and GC. Patients were divided into three groups: (1) palliative treatment; (2) treatment with curative intent, and (3) survivors. Reliability and validity tests were performed.
  
  
  RESULTS
  One-hundred sixty-three patients were included: 62 women and 101 men (mean age, 54.9 years; range, 22-82 years). Sixty-nine, seventy-three, and twenty-one patients were allocated into groups 1, 2, and 3, respectively. Questionnaire compliance rates were high and were well accepted. Group 3 patients reported better functional HRQL scores and lower symptom scores than patients in groups 2 and 1. Scales in the QLQ-C30 and QLQ-OG25 distinguished among other clinically distinct groups of patients. Cronbach's α coefficients of all multi-item scales of the QLQ-OG25 instrument were >0.7 (range, 0.7-0.83). Multitrait scaling analysis demonstrated good convergent and discriminant validity, even adjusting by location. Test-retest scores were consistent.
  
  
  CONCLUSIONS
  The Mexican-Spanish version of the EORTC QLQ-OG25 questionnaire is reliable and valid for HRQL measurement in patients with esophagogastric cancer and can be used in clinical trials in the Mexican community.
authors.affiliation: División de Investigación Clínica, Instituto Nacional de Cancerología, Mexico City, Mexico. lfonate@gmail.com
authors.forename: Luis F
authors.initials: LF
authors.lastname: Oñate-Ocaña
authors.forename: Natalia
authors.initials: N
authors.lastname: Velázquez-Monroy
authors.forename: Luis
authors.initials: L
authors.lastname: Vázquez
authors.forename: Pablo
authors.initials: P
authors.lastname: Espinosa-Mireles-de-Villafranca
authors.forename: Elvia
authors.initials: E
authors.lastname: Núñez-Rosas
authors.forename: Maira
authors.initials: M
authors.lastname: Ovando-Lezama
authors.forename: Diana
authors.initials: D
authors.lastname: Vilar-Compte
authors.forename: Gabriela
authors.initials: G
authors.lastname: García-Hubard
authors.forename: José F
authors.initials: JF
authors.lastname: Carrillo
authors.forename: Jane M
authors.initials: JM
authors.lastname: Blazeby
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Aiello-Crocifoglio
mesh_terms: D000230:Adenocarcinoma / Q000523:psychology* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004938:Esophageal Neoplasms / Q000523:psychology* / Q000628:therapy; D004943:Esophagogastric Junction / Q000503:physiopathology*; D005260:Female; D006304:Health Status; D006801:Humans; D007802:Language; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010166:Palliative Care; D011594:Psychometrics / Q000295:instrumentation* / Q000706:statistics & numerical data; D011788:Quality of Life; D015203:Reproducibility of Results; D018434:Sickness Impact Profile; D013274:Stomach Neoplasms / Q000523:psychology* / Q000628:therapy; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology; D014177:Translations; D055815:Young Adult