title: Lithium perchlorate-nitromethane-promoted alkylation of anilines with arylmethanols.
abstract: A new application of lithium perchlorate-nitromethane (LPNM) for the formation of aromatic C-N and C-C bonds is introduced. LPNM-promoted reactions of anilines with diarylmethanols selectively generate N-alkylated anilines or mono and double Friedel-Crafts alkylation products under different conditions by changing the reaction time, reaction temperature, and the ratio of the reactants. This method does not require the use of transition metal catalysts to prepare alkylated aniline derivatives.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, 199 Renai Street, Suzhou, Jiangsu 215123, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Mao
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zou
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000478:Alkylation; D000814:Aniline Compounds / Q000737:chemistry*; D018020:Lithium Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D000432:Methanol / Q000737:chemistry*; D009595:Nitroparaffins / Q000737:chemistry*; D010472:Perchlorates / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D018020:Lithium Compounds; D009595:Nitroparaffins; D010472:Perchlorates; D008697:Methane; C054684:lithium perchlorate; C008640:nitromethane; C023650:aniline; D000432:Methanol