title: Cadaver donor kidney retransplantation in the pediatric patient: complications and long-term outcome.
abstract: OBJECTIVE
  We compared the outcome of second and third kidney allografts with that of the first kidney allograft in pediatric recipients.
  
  
  METHODS
  We classified 173 cadaveric kidney recipients into 2 groups. Group 1 comprised 120 first transplants and group 2 comprised 53 retransplants, including 43 second and 10 third transplants. We compared demographic characteristics and survival in groups 1 and 2.
  
  
  RESULTS
  Group 1 consisted of 78 boys and 42 girls with a mean ± SD age of 11.5 ± 4.2 years. Group 2 consisted of 37 boys and 16 girls with a mean age of 10.4 ± 4.7 years. One, 5, 10 and 15-year graft survival rates were 78.7%, 64.3%, 54.5% and 50.7% for first transplants vs 82.8%, 57.8%, 57.8% and 41.3%, respectively, for retransplants (p = 0.757). Patient survival at 1, 5 and 15-year was 95.8%, 89.6%, 84.9% in the first transplant group vs 93.6%, 93.6% and 93.6%, respectively, in the retransplant group (p = 0.0.63). Graft survival was significantly higher in patients who did vs did not receive calcineurin inhibitors in the 2 groups (p = 0.02).
  
  
  CONCLUSIONS
  Kidney retransplantation in the pediatric population can yield excellent long-term outcomes, especially in patients treated with calcineurin inhibitors.
authors.affiliation: Departments of Urology and Pediatric Nephrology (DM, ALdP), Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Lledó-García
authors.forename: Carlos
authors.initials: C
authors.lastname: Hernández-Fernández
authors.forename: David
authors.initials: D
authors.lastname: Subirá-Ríos
authors.forename: José Maria
authors.initials: JM
authors.lastname: Díez-Cordero
authors.forename: Ramón
authors.initials: R
authors.lastname: Durán-Merino
authors.forename: Felipe
authors.initials: F
authors.lastname: Herranz-Amo
authors.forename: Fernando
authors.initials: F
authors.lastname: Verdú-Tartajo
authors.forename: Mercedes
authors.initials: M
authors.lastname: Moralejo-Gárate
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Bueno-Chomón
authors.forename: Gabriel
authors.initials: G
authors.lastname: Ogaya-Pinies
authors.forename: Dolores
authors.initials: D
authors.lastname: Morales
authors.forename: Augusto
authors.initials: A
authors.lastname: Luque-de Pablos
mesh_terms: D000293:Adolescent; D000328:Adult; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D019233:Retreatment; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult