title: The effect of gonadotropin-releasing hormone analog treatment (leuprolide) on body fat distribution in idiopathic central precocious puberty.
abstract: Gonadotropin-releasing hormone analog (GnRHa) therapy is used in idiopathic central precocious puberty (ICPP) worldwide. It has also been shown that during this therapy, body mass index (BMI) increases slightly as a side effect. We investigated the side effects of GnRHa treatment in ICPP on body composition and insulin resistance (IR). Twenty girls (7.55 +/- 1.02 y) with ICPP were treated with GnRHa (leuprolide) for an average of 20.83 +/- 4.8 months. Bioelectrical Impedance Analysis (BIA) was used to measure the body's fat balance. Nine patients out of 20 (45%) had significant gain weight. We showed a significant elevation in trunk fat mass compare to baseline values (p < 0.01). These nine patients had high homeostasis model assessment (HOMA)-IR and low glucose/insulin (G/I) index. This study showed a slight increase in BMI, moderate increase in total body fat, and exaggerated elevation in trunk fat mass and IR in GnRHa-treated ICPP children.
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Mehmet Emre
authors.initials: ME
authors.lastname: Taşcilar
authors.forename: Pelin
authors.initials: P
authors.lastname: Bilir
authors.forename: Ayşehan
authors.initials: A
authors.lastname: Akinci
authors.forename: Kenan
authors.initials: K
authors.lastname: Köse
authors.forename: Dilek
authors.initials: D
authors.lastname: Akçora
authors.forename: Deniz
authors.initials: D
authors.lastname: Inceoğlu
authors.forename: Suat Omer
authors.initials: SO
authors.lastname: Fitöz
mesh_terms: D001823:Body Composition / Q000187:drug effects; D050218:Body Fat Distribution; D015992:Body Mass Index; D002648:Child; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology*; D006801:Humans; D016729:Leuprolide / Q000494:pharmacology*; D011629:Puberty, Precocious / Q000503:physiopathology*
chemical_list: D005300:Fertility Agents, Female; D016729:Leuprolide