title: Effect of oryzanol and ferulic acid on the glucose metabolism of mice fed with a high-fat diet.
abstract: The effects of oryzanol and ferulic acid on the glucose metabolism of high-fat-fed mice were investigated. Male C57BL/6N mice were randomly divided into 4 groups: NC group fed with normal control diet; HF group fed with high-fat (17%) diet; HF-O group fed with high-fat diet supplemented with 0.5% oryzanol; and HF-FA group fed with high-fat diet supplemented with 0.5% ferulic acid. All animals were allowed free access to the experimental diets and water for 7 wk. At the end of the experimental period, the HF-O and HF-FA groups exhibited significantly lower blood glucose level and glucose-6-phosphatase (G6pase) and phosphoenolpyruvate carboxykinase (PEPCK) activities, and higher glycogen and insulin concentrations and glucokinase (GK) activity compared with NC and HF groups. The results of this study illustrate that both oryzanol and ferulic acid could reduce the risk of high-fat diet-induced hyperglycemia via regulation of insulin secretion and hepatic glucose-regulating enzyme activities.
authors.affiliation: Dept. of Food Science and Nutrition, Kyungpook National Univ., Daegu, Republic of Korea.
authors.forename: Myoung Jin
authors.initials: MJ
authors.lastname: Son
authors.forename: Catherine W
authors.initials: CW
authors.lastname: Rico
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Nam
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Kang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D003373:Coumaric Acids / Q000627:therapeutic use*; D004041:Dietary Fats / Q000009:adverse effects; D005941:Glucokinase / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006943:Hyperglycemia / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010666:Phenylpropionates / Q000627:therapeutic use*; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism; D011897:Random Allocation; D013997:Time Factors
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D003373:Coumaric Acids; D004041:Dietary Fats; D007004:Hypoglycemic Agents; D007328:Insulin; D010666:Phenylpropionates; D006003:Glycogen; C004999:ferulic acid; D005941:Glucokinase; D005952:Glucose-6-Phosphatase; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D005947:Glucose; C013172:gamma-oryzanol