title: Possible gabapentin and ketamine interaction causing prolonged central nervous system depression during post-operative recovery following cervical laminoplasty: a case report.
abstract: BACKGROUND
  The drugs gabapentin and ketamine are used frequently in the peri-operative setting. There is poor documentation whether or not gabapentin and ketamine interact to cause prolonged depression of the central nervous system.
  
  
  METHODS
  The following is a case report in which a patient, a 58-year-old African-American man, with a history of post-traumatic stress disorder and chronic pain underwent a cervical laminoplasty procedure. The patient presented post-operatively in a dissociative state with paralysis, anarthria and preservation of consciousness. All organic causes were excluded, with the exception of prolonged central nervous system depression from a gabapentin/ketamine drug interaction. A new onset conversion disorder could also not be excluded.
  
  
  CONCLUSIONS
  Although this case by itself is not enough evidence to substantiate a true adverse reaction between gabapentin and ketamine, it is enough to warrant further investigation.
authors.affiliation: Tripler Army Medical Center, Department of Surgery, 1 Jarrett White Road, Honolulu, HI 96859-5000, USA. aelyassi@gmail.com.
authors.forename: Ali R
authors.initials: AR
authors.lastname: Elyassi
authors.forename: Robert P
authors.initials: RP
authors.lastname: Long
authors.forename: Robert P
authors.initials: RP
authors.lastname: Bejnarowicz
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Schoneboom