title: Prognosis of mucinous histology for patients with radically resected stage II and III colon cancer.
abstract: BACKGROUND
  Previous studies investigating the prognostic role of mucinous histology of colorectal cancer produced conflicting results. This retrospective analysis was carried out in order to explore whether mucinous adenocarcinoma (MC) is associated with a comparatively worse prognosis than that of nonmucinous adenocarcinoma (NMC) for patients undergoing curative resection for stage II and III colon cancer.
  
  
  METHODS
  This study involved 1025 unselected patients who underwent curative surgery for sporadic colon cancer and follow-up procedures at six different oncology departments.
  
  
  RESULTS
  MCs accounted for 17.4% (n=178) of tumours. Patients with MC had 5- and 8-year overall survival rates of 78.6% and 68.8%, respectively, compared with 72.3% and 63.8%, respectively, for patients with nonmucinous tumours. Multivariate analysis using the Cox proportional hazards model showed that the clinically significant prognostic factors were stage of disease and adjuvant chemotherapy. No statistically significant interaction between mucinous histology and adjuvant chemotherapy was found.
  
  
  CONCLUSIONS
  For patients with stage II and III colon cancer who underwent curative surgery, mucinous histology has no significant correlation with prognosis compared with NMC. This retrospective analysis suggests a comparable benefit from adjuvant chemotherapy for MC compared with NMC.
authors.affiliation: Department of Oncology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Presidio San Salvatore, Pesaro. Electronic address: catalano_v@yahoo.it.
authors.forename: V
authors.initials: V
authors.lastname: Catalano
authors.affiliation: Department of Medical Oncology, 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa.
authors.forename: F
authors.initials: F
authors.lastname: Loupakis
authors.affiliation: Department of Oncology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Presidio San Salvatore, Pesaro.
authors.forename: F
authors.initials: F
authors.lastname: Graziano
authors.affiliation: Department of Oncology, Ospedale 'A. Murri', Fermo.
authors.forename: R
authors.initials: R
authors.lastname: Bisonni
authors.affiliation: Department of Oncology, Ospedale di Macerata, Macerata.
authors.forename: U
authors.initials: U
authors.lastname: Torresi
authors.affiliation: Department of Oncology, Università Campus BioMedico, Rome.
authors.forename: B
authors.initials: B
authors.lastname: Vincenzi
authors.affiliation: Department of Oncology, Ospedale 'E. Profili', Fabriano.
authors.forename: D
authors.initials: D
authors.lastname: Mari
authors.affiliation: Department of Oncology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Presidio San Salvatore, Pesaro.
authors.forename: P
authors.initials: P
authors.lastname: Giordani
authors.affiliation: Department of Oncology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Presidio San Salvatore, Pesaro.
authors.forename: P
authors.initials: P
authors.lastname: Alessandroni
authors.affiliation: Department of Medical Oncology, 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa.
authors.forename: L
authors.initials: L
authors.lastname: Salvatore
authors.affiliation: Department of Medical Oncology, 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa.
authors.forename: L
authors.initials: L
authors.lastname: Fornaro
authors.affiliation: Department of Oncology, Università Campus BioMedico, Rome.
authors.forename: D
authors.initials: D
authors.lastname: Santini
authors.affiliation: Department of Oncology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Presidio San Salvatore, Pesaro.
authors.forename: A M
authors.initials: AM
authors.lastname: Baldelli
authors.affiliation: Department of Oncology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Presidio San Salvatore, Pesaro.
authors.forename: D
authors.initials: D
authors.lastname: Rossi
authors.affiliation: Department of Oncology, Ospedale 'A. Murri', Fermo.
authors.forename: L
authors.initials: L
authors.lastname: Giustini
authors.affiliation: Department of Oncology, Ospedale 'E. Profili', Fabriano.
authors.forename: R R
authors.initials: RR
authors.lastname: Silva
authors.affiliation: Department of Medical Oncology, 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa.
authors.forename: A
authors.initials: A
authors.lastname: Falcone
authors.affiliation: Department of Oncology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Presidio San Salvatore, Pesaro.
authors.forename: S
authors.initials: S
authors.lastname: D'Emidio
authors.affiliation: Istituto di Biomatematica, Università degli Studi di Urbino, Urbino, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rocchi
authors.affiliation: Department of Oncology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Presidio San Salvatore, Pesaro.
authors.forename: S
authors.initials: S
authors.lastname: Luzi Fedeli
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies