title: 2-difluoromethylene-4-methylenepentanoic acid, a paradoxical probe able to mimic the signaling role of 2-oxoglutaric acid in cyanobacteria.
abstract: 2-Difluoromethylene-4-methylenepentanoic acid (DFMPA), a seemingly deviated analog of 2-oxoglutaric acid (2-OG), could surprisingly mimic its signaling function in cyanobacteria. Computer modeling revealed the favorable binding of DFMPA toward the 2-OG receptor, NtcA, via mutual conformational changes, suggesting that structural alteration of 2-OG is tolerated for it to exercise its signaling role. This extremely useful finding could be exploited for the design of affinity probes with which to study new 2-OG receptors in related signaling pathways.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, PR China.
authors.forename: Xinjun
authors.initials: X
authors.lastname: Liu
authors.forename: Han
authors.initials: H
authors.lastname: Chen
authors.forename: Erik
authors.initials: E
authors.lastname: Laurini
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Valentina
authors.initials: V
authors.lastname: Dal Col
authors.forename: Paola
authors.initials: P
authors.lastname: Posocco
authors.forename: Fabio
authors.initials: F
authors.lastname: Ziarelli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fermeglia
authors.forename: Cheng-Cai
authors.initials: CC
authors.lastname: Zhang
authors.forename: Sabrina
authors.initials: S
authors.lastname: Pricl
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D000458:Cyanobacteria / Q000378:metabolism*; D007656:Ketoglutaric Acids / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D010421:Pentanoic Acids / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C560542:2-difluoromethylene-4-methylenepentanoic acid; D007656:Ketoglutaric Acids; D010421:Pentanoic Acids