title: Wernicke-Korsakoff syndrome in the course of thyrotoxicosis - a case report.
abstract: Wernicke-Korsakoff syndrome (also called Wernicke's encephalopathy) is a potentially fatal, neuropsychiatric syndrome caused most frequently by thiamine deficiency. The three classic symptoms found together are confusion, ataxia and eyeball manifestations. Memory disturbances can also be symptoms. Wernicke's encephalopathy mainly results from alcohol abuse, but also from malnutrition, cancer, chronic dialysis, thyrotoxicosis and, in well-founded cases, encephalopathy associated with autoimmune thyroid disease (EAATD). The coexistence of many factors makes a proper diagnosis difficult, delays appropriate treatment and consequently reduces the chance of complete recovery. We present the case of a 53 year-old female with Wernicke's encephalopathy caused by chronic malnutrition, surgical operation, as well as thyrotoxicosis. She received treatment with intravenous thiamine administration and also anti-thyroid treatment which caused satisfactory regression of her neurological symptoms.
authors.affiliation: Endocrinological Ward, Third Provincial Hospital, Rybnik, Poland. jwierzbickachmiel@wp.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Wierzbicka-Chmiel
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Wierzbicki
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kajdaniuk
authors.forename: Ryszard
authors.initials: R
authors.lastname: Sędziak
authors.forename: Bogdan
authors.initials: B
authors.lastname: Marek
mesh_terms: D005260:Female; D006801:Humans; D020915:Korsakoff Syndrome / Q000209:etiology* / Q000628:therapy; D044342:Malnutrition / Q000150:complications; D008875:Middle Aged; D013831:Thiamine / Q000008:administration & dosage*; D013832:Thiamine Deficiency / Q000150:complications* / Q000628:therapy; D013971:Thyrotoxicosis / Q000150:complications* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D013831:Thiamine