title: Correlation between tps and cea in patients with colorectal-cancer.
abstract: Serum TPS and CEA levels were measured in 173 cancer patients with various disease stages. The patients were divided into 4 groups: preoperative group, 16 patients in whom TPS and CEA were measured pre- and postoperatively; group I, 66 newly diagnosed patients up to 40 days post surgery; group II, 86 patients whose blood was taken 40-365 days post surgery, and group III, 47 patients on long-term follow-up in whom blood was taken more than one year after surgery. The median preoperative TPS levels were significantly higher (p<0.01) than the postoperative levels. Patients with Dukes' D had significantly higher TPS (p<0.01) and CEA levels as compared to patients with Dukes' B or C. For both Dukes' B and C stages there was a significant increase in median TPS level between group I and II and III. There was no similar increase in median CEA level. Serial measurements in individual patients show a significant increase in TPS levels between groups I, II and III. In Dukes' D patients, individual TPS levels decreased in response to therapy. There was a significant correlation between TPS and CEA levels. These results suggest that TPS measurement is additive to CEA in follow-up of asymptomatic patients, and to monitor response to therapy in patients with metastatic disease.
authors.affiliation: HASHARON HOSP,GOLDA MED CTR,DEPT PATHOL,IL-49372 PETAH TIQWA,ISRAEL. MEIR HOSP,ONCOL UNIT,KEFAR SAVA,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL. BEILINSON MED CTR,DEPT ONCOL,IL-49100 PETAH TIQWA,ISRAEL.
authors.forename: B
authors.initials: B
authors.lastname: Klein
authors.forename: I
authors.initials: I
authors.lastname: Levin
authors.forename: M
authors.initials: M
authors.lastname: Michaeli
authors.forename: L
authors.initials: L
authors.lastname: Wolfson
authors.forename: R
authors.initials: R
authors.lastname: Gal
authors.forename: I
authors.initials: I
authors.lastname: Shapira
authors.forename: B
authors.initials: B
authors.lastname: Kfir
authors.forename: E
authors.initials: E
authors.lastname: Rakovsky
authors.forename: T
authors.initials: T
authors.lastname: Klein