title: Emerging models and paradigms for stem cell ageing.
abstract: Ageing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair. Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal and aberrant differentiation potential.
authors.affiliation: Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
authors.forename: D Leanne
authors.initials: DL
authors.lastname: Jones
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Rando
mesh_terms: D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D016922:Cellular Senescence; D004249:DNA Damage; D044127:Epigenesis, Genetic; D042822:Genomic Instability; D006801:Humans; D008954:Models, Biological; D013234:Stem Cells / Q000166:cytology*; D014158:Transcription, Genetic