title: Eight weeks of conjugated linoleic acid supplementation has no effect on antioxidant status in healthy overweight/obese Korean individuals.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of CLA supplementation on antioxidant metabolism in healthy overweight/obese Korean individuals.
  
  
  METHODS
  We performed a randomized, double-blind, placebo-controlled trial, where 29 healthy overweight/obese (BMI ≥ 23 kg/m(2)) participants (2 men and 27 women) were randomly selected to receive placebo (n = 15, 2.4 g olive oil/day) or 2.4 g/day CLA mixture (n = 14, 36.9% of cis-9, trans-11 and 37.9% of trans-10, cis-12) for 8 weeks.
  
  
  RESULTS
  There were no significant differences in plasma total radical-trapping antioxidant potential (TRAP), lipid peroxidation (conjugated dienes), lipid-soluble antioxidant vitamin concentration, erythrocyte antioxidant enzyme (superoxide dismutase, catalase, glutathione peroxidase) activities, and leukocyte DNA damage between the CLA and placebo groups.
  
  
  CONCLUSIONS
  The data suggest that short-term supplementation (8 weeks) with CLA (2.4 g/day) might have no significant effects on lipid peroxidation and antioxidant metabolism.
authors.affiliation: Department of Food and Nutrition, Kyungnam University, Changwon, Korea.
authors.forename: Jungmi
authors.initials: J
authors.lastname: Kim
authors.forename: Hyun-Dong
authors.initials: HD
authors.lastname: Paik
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Shin
authors.forename: Eunju
authors.initials: E
authors.lastname: Park
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D044466:Asian People; D001823:Body Composition / Q000187:drug effects; D002374:Catalase / Q000097:blood; D004249:DNA Damage / Q000187:drug effects; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009765:Obesity / Q000188:drug therapy*; D000069463:Olive Oil; D050177:Overweight / Q000188:drug therapy*; D010938:Plant Oils; D056910:Republic of Korea; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors
chemical_list: D000975:Antioxidants; D044243:Linoleic Acids, Conjugated; D000069463:Olive Oil; D010938:Plant Oils; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase