title: Exposure to dibenzofuran affects lung mitochondrial function in vitro.
abstract: Environmental pollutants, such as dioxins and furans, are extremely toxic and related with pulmonary diseases development. Impairment of mitochondrial function has been shown in pollutant-induced hepatic injury, but it has not been addressed in lungs, even though lung mitochondria are primary cellular targets for pollutants-induced toxicity. In isolated lung mitochondria, dibenzofuran significantly increased the lag phase preceding mitochondrial repolarization, suggesting a decrease in the efficiency of the mitochondrial phosphorylative system.
authors.affiliation: Center for Neurosciences and Cell Biology, Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
authors.forename: Filipe V
authors.initials: FV
authors.lastname: Duarte
authors.forename: Anabela M
authors.initials: AM
authors.lastname: Simões
authors.forename: João S
authors.initials: JS
authors.lastname: Teodoro
authors.forename: Anabela P
authors.initials: AP
authors.lastname: Rolo
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Palmeira
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001572:Benzofurans / Q000633:toxicity*; D045304:Cytochromes c; D008168:Lung / Q000166:cytology / Q000187:drug effects*; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects*; D010101:Oxygen Consumption; D010539:Permeability; D013552:Swine
chemical_list: D001572:Benzofurans; C023614:dibenzofuran; D045304:Cytochromes c; D000251:Adenosine Triphosphatases