title: Iodinated contrast media and the role of renal replacement therapy.
abstract: Iodinated contrast media are among the most commonly used pharmacologic agents in medicine. Although generally highly safe, iodinated contrast media are associated with several adverse effects, most significantly the risk of acute kidney injury, particularly in patients with underlying renal dysfunction. By virtue of their pharmacokinetic characteristics, these contrast agents are efficiently cleared by hemodialysis and to a lesser extent, hemofiltration. This has led to research into the capacity for renal replacement therapies to prevent certain adverse effects of iodinated contrast. This review examines the molecular and pharmacokinetic characteristics of iodinated contrast media and critically analyzes data from past studies on the role of renal replacement therapy to prevent adverse effects of these diagnostic agents.
authors.affiliation: Renal Section, Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, PA, USA. weisbordsd@upmc.edu
authors.forename: Steven D
authors.initials: SD
authors.lastname: Weisbord
authors.forename: Paul M
authors.initials: PM
authors.lastname: Palevsky
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000517:prevention & control*; D003287:Contrast Media / Q000009:adverse effects* / Q000737:chemistry / Q000493:pharmacokinetics; D017583:Hemodiafiltration; D006801:Humans; D017613:Iodine Compounds / Q000009:adverse effects* / Q000737:chemistry / Q000493:pharmacokinetics; D006435:Renal Dialysis
chemical_list: D003287:Contrast Media; D017613:Iodine Compounds