title: Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging.
abstract: A new small molecule probe for in vivo lipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.
authors.affiliation: Bioorganic Division, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Lee
authors.forename: Ju-Hoon
authors.initials: JH
authors.lastname: So
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Jeon
authors.forename: Eun Bok
authors.initials: EB
authors.lastname: Choi
authors.forename: Yu-Ri
authors.initials: YR
authors.lastname: Lee
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
authors.forename: Cheol-Hee
authors.initials: CH
authors.lastname: Kim
authors.forename: Myung Ae
authors.initials: MA
authors.lastname: Bae
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Ahn
mesh_terms: D041721:3T3-L1 Cells; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D050356:Lipid Metabolism; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D015027:Zebrafish
chemical_list: D005456:Fluorescent Dyes