title: Tigliane-type diterpenoid glycosides from Euphorbia fischeriana.
abstract: Investigation of whole plants of Euphorbia fischeriana afforded three new tigliane-diterpenoid glycosides, fischerosides A-C (1-3), together with 11 known diterpenoids. Fischerosides A-C (1-3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1-5. The new compound 3 showed an EC₅₀ value of 0.02 μM and a therapeutic index (TI) of 17.50, while prostratin (4) and 12-deoxyphorbol-13,20-diacetate (5) showed significantly greater anti-HIV-1 activity.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Pan
authors.forename: Ping-Lei
authors.initials: PL
authors.lastname: Fang
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Ni
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Chang-Xiang
authors.initials: CX
authors.lastname: Chen
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Chang-Tian
authors.initials: CT
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D019380:Anti-HIV Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D005960:Glucosides; C561171:fischeroside A; C561172:fischeroside B; C561173:fischeroside C