title: Possible seizure suppression via deep brain stimulation of the thalamic ventralis oralis posterior nucleus.
abstract: Surgical treatment of intractable epilepsy with deep brain stimulation (DBS) has been shown to be of therapeutic benefit in some patients and with the recent publication of a randomised control study its use is likely to increase in the future. We describe a patient who developed a focal epileptic seizure within a few seconds of momentarily turning off the DBS stimulator in the nucleus ventralis oralis posterior, with which she was successfully treated for tremor. The seizure was the result of a newly diagnosed primary brain tumor. We suggest that the nucleus ventralis oralis posterior may be another thalamic target of DBS in epilepsy.
authors.affiliation: Department of Neurology, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. benwakerley@fastmail.fm
authors.forename: Benjamin
authors.initials: B
authors.lastname: Wakerley
authors.forename: Patrick
authors.initials: P
authors.lastname: Schweder
authors.forename: Alex
authors.initials: A
authors.lastname: Green
authors.forename: Tipu
authors.initials: T
authors.lastname: Aziz
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology; D046690:Deep Brain Stimulation; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000473:pathology; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000628:therapy*; D020656:Posterior Thalamic Nuclei / Q000502:physiology / Q000601:surgery*; D012640:Seizures / Q000517:prevention & control*; D014202:Tremor / Q000209:etiology / Q000628:therapy