title: Tomographic bioluminescence imaging reconstruction via a dynamically sparse regularized global method in mouse models.
abstract: Generally, the performance of tomographic bioluminescence imaging is dependent on several factors, such as regularization parameters and initial guess of source distribution. In this paper, a global-inexact-Newton based reconstruction method, which is regularized by a dynamic sparse term, is presented for tomographic reconstruction. The proposed method can enhance higher imaging reliability and efficiency. In vivo mouse experimental reconstructions were performed to validate the proposed method. Reconstruction comparisons of the proposed method with other methods demonstrate the applicability on an entire region. Moreover, the reliable performance on a wide range of regularization parameters and initial unknown values were also investigated. Based on the in vivo experiment and a mouse atlas, the tolerance for optical property mismatch was evaluated with optical overestimation and underestimation. Additionally, the reconstruction efficiency was also investigated with different sizes of mouse grids. We showed that this method was reliable for tomographic bioluminescence imaging in practical mouse experimental applications.
authors.affiliation: Chinese Academy of Sciences, Medical Image Processing Group, Institute of Automation, Beijing 100190, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.forename: Chenghu
authors.initials: C
authors.lastname: Qin
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.forename: Shouping
authors.initials: S
authors.lastname: Zhu
authors.forename: Dong
authors.initials: D
authors.lastname: Han
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
mesh_terms: D000465:Algorithms; D000818:Animals; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D008163:Luminescent Measurements / Q000379:methods*; D051379:Mice; D023421:Models, Animal; D015203:Reproducibility of Results; D014054:Tomography / Q000379:methods*; D055114:X-Ray Microtomography