title: The molecular genetics and tumor pathogenesis of meningiomas and the future directions of meningioma treatments.
abstract: Meningiomas are mostly benign, slow-growing tumors of the CNS that originate from arachnoidal cap cells. While monosomy 22 is the most frequent genetic abnormality found in meningiomas, a multitude of other aberrant chromosomal alterations, signaling pathways, and growth factors have been implicated in its pathogenesis. Losses on 22q12.2, a region encoding the tumor suppressor gene merlin, represent the most common genetic alterations in early meningioma formation. Malignant meningioma progression, however, is associated with more complex karyotypes and greater genetic instability. Cytogenetic studies of atypical and anaplastic meningiomas revealed gains and losses on chromosomes 9, 10, 14, and 18, with amplifications on chromosome 17. However, the specific gene targets in a majority of these chromosomal abnormalities remain elusive. Studies have also implicated a myriad of aberrant signaling pathways involved with meningioma tumorigenesis, including those involved with proliferation, angiogenesis, and autocrine loops. Understanding these disrupted pathways will aid in deciphering the relationship between various genetic changes and their downstream effects on meningioma pathogenesis. Despite advancements in our understanding of meningioma pathogenesis, the conventional treatments, including surgery, radiotherapy, and stereotactic radiosurgery, have remained largely stagnant. Surgery and radiation therapy are curative in the majority of lesions, yet treatment remains challenging for meningiomas that are recurrent, aggressive, or refractory to conventional treatments. Future therapies will include combinations of targeted molecular agents as a result of continued progress in the understanding of genetic and biological changes associated with meningiomas.
authors.affiliation: Department of Neurological Surgery, University of California-Los Angeles, 695 Charles E. Young Drive South, Los Angeles, CA 90095-1761, USA.
authors.forename: Winward
authors.initials: W
authors.lastname: Choy
authors.forename: Won
authors.initials: W
authors.lastname: Kim
authors.forename: Daniel
authors.initials: D
authors.lastname: Nagasawa
authors.forename: Stephanie
authors.initials: S
authors.lastname: Stramotas
authors.forename: Andrew
authors.initials: A
authors.lastname: Yew
authors.forename: Quinton
authors.initials: Q
authors.lastname: Gopen
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Parsa
authors.forename: Isaac
authors.initials: I
authors.lastname: Yang
mesh_terms: D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D018450:Disease Progression; D006801:Humans; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000628:therapy*; D008579:Meningioma / Q000235:genetics* / Q000628:therapy*; D009006:Monosomy; D015398:Signal Transduction / Q000235:genetics