title: Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs.
abstract: OBJECTIVE
  There is strong evidence associating migraine with a variety of comorbid disorders, including cardiovascular disease and stroke, in which oxidative stress seems to be an important underlying mechanism. The aim of the study was to investigate in migraineurs the body oxidant/antioxidant balance and paraoxonase enzyme activities as a measure of HDL functionality.
  
  
  METHODS
  Oxidative stress index, total oxidant status and antioxidant status were examined in addition to the paraoxonase and arylesterase enzyme activities in sixty-two migraineurs and fifty healthy control subjects.
  
  
  RESULTS
  Serum arylesterase activities were significantly lower in migraineurs (p=0.0065), whereas total oxidant status was higher in patients compared to the controls (p=0.0035).
  
  
  CONCLUSIONS
  This preliminary study showed that oxidative/antioxidative balance shifted towards the oxidative status in migraine. Moreover, the results also suggested that decreased arylesterase activities might be associated with HDL-related disfunction.
authors.affiliation: Central laboratories of Antalya Education and Research Hospital of Ministry of Health, Turkey. necatyilmaz@hotmail.com
authors.forename: Necat
authors.initials: N
authors.lastname: Yilmaz
authors.forename: Ozgur
authors.initials: O
authors.lastname: Aydin
authors.forename: Aysenur
authors.initials: A
authors.lastname: Yegin
authors.forename: Aysun
authors.initials: A
authors.lastname: Tiltak
authors.forename: Esin
authors.initials: E
authors.lastname: Eren
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003710:Demography; D004827:Epilepsy / Q000097:blood / Q000150:complications / Q000201:enzymology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008881:Migraine Disorders / Q000097:blood* / Q000201:enzymology*; D016877:Oxidants / Q000097:blood*
chemical_list: D000975:Antioxidants; D008055:Lipids; D016877:Oxidants; D005340:Fibrinogen; D002097:C-Reactive Protein; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human