title: Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods.
abstract: A combination of flow and batch chemistries has been successfully applied to the assembly of a series of trisubstituted drug-like pyrrolidines. This study demonstrates the efficient preparation of a focused library of these pharmaceutically important structures using microreactor technologies, as well as classical parallel synthesis techniques, and thus exemplifies the impact of integrating innovative enabling tools within the drug discovery process.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, UK.
authors.forename: Marcus
authors.initials: M
authors.lastname: Baumann
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: Christoph
authors.initials: C
authors.lastname: Kuratli
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Rainer E
authors.initials: RE
authors.lastname: Martin
authors.forename: Josef
authors.initials: J
authors.lastname: Schneider
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis*; D054852:Small Molecule Libraries / Q000138:chemical synthesis*
chemical_list: D011759:Pyrrolidines; D054852:Small Molecule Libraries