title: [Regulation of the functional and mechanical properties of platelet and red blood cells by nitric oxide donors].
abstract: The effect of NO donors (sodium nitroprusside, S-nitrosoglutathione, dinitrosyl-iron complexes) on the functional and mechanical properties of human platelets and red blood cells has been investigated. It has been established by atomic force microscopy that NO donor-induced platelet disaggregation is accompanied by changes in the elastic properties of cells. It has been shown that, in the presence of NO donors, the detergent-induced hemolysis of red blood cells is delayed, and the elasticity modulus of these cells decreases. The results obtained indicate that NO donors regulate the structural and functional properties of platelets and red blood cells.
authors.forename: E V
authors.initials: EV
authors.lastname: Shamova
authors.forename: O D
authors.initials: OD
authors.lastname: Bichan
authors.forename: E S
authors.initials: ES
authors.lastname: Drozd
authors.forename: I V
authors.initials: IV
authors.lastname: Gorudko
authors.forename: S A
authors.initials: SA
authors.lastname: Chizhik
authors.forename: K B
authors.initials: KB
authors.lastname: Shumaev
authors.forename: S N
authors.initials: SN
authors.lastname: Cherenkevich
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
mesh_terms: D001792:Blood Platelets / Q000378:metabolism* / Q000648:ultrastructure; D003902:Detergents / Q000494:pharmacology; D004548:Elasticity / Q000187:drug effects; D004912:Erythrocytes / Q000378:metabolism* / Q000648:ultrastructure; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D018625:Microscopy, Atomic Force / Q000379:methods; D020030:Nitric Oxide Donors / Q000494:pharmacology*
chemical_list: D003902:Detergents; D020030:Nitric Oxide Donors