title: Calcitonin gene-related peptide is an important regulator of cutaneous immunity: effect on dendritic cell and T cell functions.
abstract: Some cutaneous inflammations are induced by percutaneous exposure to foreign Ags, and many chemical mediators regulate this inflammation process. One of these mediators, calcitonin gene-related peptide (CGRP), is a neuropeptide released from nerve endings in the skin. CGRP binds to its receptors composed of receptor activity-modifying protein 1 and calcitonin receptor-like receptor to modulate immune cell function. We show that CGRP regulates skin inflammation under physiological conditions, using contact hypersensitivity (CHS) models of receptor activity-modifying protein 1-deficient mice. CGRP has different functions in CHS responses mediated by Th1 or Th2 cells; it inhibits Th1-type CHS, such as 2,4,6-trinitrochlorobenzene-induced CHS, but promotes Th2-type CHS, such as FITC-induced CHS. CGRP inhibits the migration of Langerin(+) dermal dendritic cells to the lymph nodes in 2,4,6-trinitrochlorobenzene-induced CHS, and upregulates IL-4 production of T cells in the draining lymph nodes in FITC-CHS. These findings suggest that CGRP regulates several types of CHS reactions under physiological conditions and plays an important role in cutaneous immunity.
authors.affiliation: Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Mikami
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsushita
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kato
authors.forename: Rumi
authors.initials: R
authors.lastname: Kawasaki
authors.forename: Taichi
authors.initials: T
authors.lastname: Sawazaki
authors.forename: Taeko
authors.initials: T
authors.lastname: Kishimoto
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ogitani
authors.forename: Keiko
authors.initials: K
authors.lastname: Watanabe
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Miyagi
authors.forename: Kaori
authors.initials: K
authors.lastname: Sueda
authors.forename: So-ichiro
authors.initials: S
authors.lastname: Fukada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Kazutake
authors.initials: K
authors.lastname: Tsujikawa
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology* / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology; D007109:Immunity; D051379:Mice; D018345:Mice, Knockout; D012867:Skin / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015740:Calcitonin Gene-Related Peptide