title: Cetuximab plus irinotecan in pretreated metastatic colorectal cancer patients: the ELSIE study.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer (mCRC) patients from South-East Asia and Australia.
  
  
  METHODS
  In this open-label, phase II study, the main eligibility criteria were epidermal growth factor receptor-positive mCRC with progressive disease within 3 mo of an irinotecan-based regimen as the most recent chemotherapy. Patients received cetuximab 400 mg/m2 initially, then 250 mg/m2 every week, with the same regimen of irinotecan on which the patients had progressed (4 pre-defined regimens allowed). The primary objective was evaluation of progression-free survival (PFS) at 12 wk. Secondary objectives included a further investigation of PFS, and an assessment of the overall response rate (ORR), duration of response, time to treatment failure (TTF), overall survival and the safety profile.
  
  
  RESULTS
  One hundred and twenty nine patients were enrolled from 25 centers in the Asia-Pacific region and of these 123 received cetuximab plus irinotecan. The most common recent irinotecan regimen used was 180 mg/m2 every 2 wk which had been used in 93 patients (75.6%). The PFS rate at 12 wk was 50% (95% confidence interval (CI, 41-59) and median PFS time was 12.1 wk (95% CI: 9.7-17.7). The ORR was 13.8% (95% CI: 8.3-21.2) and disease control rate was 49.6% (95% CI: 40.5-58.8). Median duration of response was 31.1 wk (95% CI: 18.0-42.6) and median overall survival was 9.5 mo (95% CI, 7.5-11.7). The median TTF was 11.7 wk (95% CI: 9.1-17.4). Treatment was generally well tolerated. The most common grade 3/4 adverse events were diarrhea (13.8%), neutropenia (8.9%), rash (5.7%) and vomiting (5.7%).
  
  
  CONCLUSIONS
  In patients from Asia and Australia, this study confirms the activity and safety of cetuximab plus irinotecan observed in previous studies in Europe and South America.
authors.affiliation: Department of Hematology-Oncology, National University Hospital, 119074 Singapore, Singapore. robert_lim@nuhs.edu.sg
authors.forename: Robert
authors.initials: R
authors.lastname: Lim
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Seock-Ah
authors.initials: SA
authors.lastname: Im
authors.forename: Ruey-Kuen
authors.initials: RK
authors.lastname: Hsieh
authors.forename: Tsz Kok
authors.initials: TK
authors.lastname: Yau
authors.forename: Anthony
authors.initials: A
authors.lastname: Bonaventura
authors.forename: Arkom
authors.initials: A
authors.lastname: Cheirsilpa
authors.forename: Regina
authors.initials: R
authors.lastname: Esser
authors.forename: Matthias
authors.initials: M
authors.lastname: Mueser
authors.forename: Suresh
authors.initials: S
authors.lastname: Advani
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000068818:Cetuximab; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D018450:Disease Progression; D018572:Disease-Free Survival; D006801:Humans; D000077146:Irinotecan; D009362:Neoplasm Metastasis; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000077146:Irinotecan; D000068818:Cetuximab; D002166:Camptothecin