title: Evolution of lipid levels in HIV-infected children treated or not with HAART in Abidjan, Cote d'Ivoire.
abstract: OBJECTIVE
  To describe lipid levels in antiretroviral (ARV)-naïve HIV-infected Ivorian children and assess their evolution after ARV-treatment initiation.
  
  
  METHODS
  Lipid concentrations were assessed at baseline and at least 6 months later in 93 children. Fifty-six children initiated ARV treatment at baseline, and 37 remained untreated.
  
  
  RESULTS
  At baseline, 65, 92 and 84% of the children had low levels of total cholesterol, HDL and APOA1, respectively, whereas 75 and 70% had triglycerides and APOB levels in the normal range. At baseline, low level of HDL cholesterol and high level of triglycerides were associated with high viral load and low levels of CD4 cell count. Levels of total, HDL cholesterol and APOA1 increased over time, and treatment was associated with a higher increase whereas levels of triglycerides and APOB decreased in treated children and remained stable in untreated group.
  
  
  CONCLUSIONS
  The initiation of antiretroviral treatment was associated with a normalization of the infection-related lipid profile.
authors.affiliation: UMI233, Institut de Recherche pour le Développement (IRD)/Université Montpellier 1, Montpellier, France. amandine.cournil@ird.fr
authors.forename: Amandine
authors.initials: A
authors.lastname: Cournil
authors.forename: Sabine
authors.initials: S
authors.lastname: Mercier-Deheuvels
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Dupuy
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Anaky
authors.forename: François
authors.initials: F
authors.lastname: Rouet
authors.forename: Patricia
authors.initials: P
authors.lastname: Fassinou
authors.forename: Philippe
authors.initials: P
authors.lastname: Msellati
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D007560:Cote d'Ivoire; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008055:Lipids / Q000097:blood*; D008297:Male; D012044:Regression Analysis
chemical_list: D008055:Lipids