title: Long-term management of vaccine-induced refractory ischemic dermatopathy in a Miniature Pinscher puppy.
abstract: A 2-month-old intact female Miniature Pinscher puppy presented with footpad swelling and crusted pustules of ear pinnae. The dog had been vaccinated with a polyvalent canine vaccine 5 days prior to the onset of clinical signs. With the history of recent vaccination, the clinical presentation and the histopathological observations were suggestive of ischemic dermatopathy. Treatment involved oral prednisolone, azathioprine, and other immune modulating drugs, which did not work. Chlorambucil plus cyclosporine therapy was initiated for vigorous immune suppression after rush therapy using intravenous immunoglobulin. Clinical signs again gradually improved with no relapse or side effects, even at a 4-month follow-up. The case report is suggested ischemic dermatopathy refractory to conventional therapy and suggests effective approaches to long-term management of the disease.
authors.affiliation: BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Disease and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143–701, South Korea.
authors.forename: Ha-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Min-Hee
authors.initials: MH
authors.lastname: Kang
authors.forename: Ju-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Kim
authors.forename: Hee-Myung
authors.initials: HM
authors.lastname: Park
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D002699:Chlorambucil / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D004285:Dogs; D003875:Drug Eruptions / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D005260:Female; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D014612:Vaccines / Q000009:adverse effects*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D014612:Vaccines; D002699:Chlorambucil; D016572:Cyclosporine