title: TLRs as pharmacological targets for plant-derived compounds in infectious and inflammatory diseases.
abstract: Toll-like receptors (TLRs) are generally involved in host immune responses against microbial invasions. Dysfunction of TLRs is closely related to infectious and inflammatory diseases, for which therapeutic manipulation with TLRs agonists and antagonists represent a promising drug strategy. Medicinal plants were used traditionally for the prevention and treatment of infectious and inflammatory diseases. Active compounds derived from these plants were also found with unique features as TLRs agonists and antagonists. These findings bring about new hopes for the application of these naturally existed TLRs modulators. They also provide evidences encouraging further research work of continued characterization for these compounds, which will become promising drug candidates in TLRs-based therapy in the future.
authors.affiliation: Department of Pharmacology, College of Pharmacy, the Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Jiang
authors.initials: J
authors.lastname: Zheng
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation; D007239:Infections / Q000188:drug therapy / Q000276:immunology*; D007249:Inflammation; D008024:Ligands; D058990:Molecular Targeted Therapy / Q000639:trends; D008517:Phytotherapy / Q000639:trends; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000276:immunology; D051193:Toll-Like Receptors / Q000819:agonists / Q000037:antagonists & inhibitors / Q000276:immunology*
chemical_list: D008024:Ligands; D010936:Plant Extracts; D051193:Toll-Like Receptors