title: Investigation of myocardial stunning after cardiopulmonary resuscitation in pigs.
abstract: OBJECTIVE
  To investigate cardiac function and myocardial perfusion during 48 h after cardiopulmonary resuscitation (CPR), further to test myocardial stunning and seek indicators for long-term survival after CPR.
  
  
  METHODS
  After 4 min of untreated ventricular fibrillation, fifteen anesthetized pigs were studied at baseline and 2 h, 4 h, 24 h, and 48 h after restoration of spontaneous circulation (ROSC). Hemodynamic data, echocardiography and gated-single photon emission computed tomography myocardial perfusion images were carried out.
  
  
  RESULTS
  Mean arterial pressure (MAP), coronary perfusion pressure (CPP) and cardiac troponin I (CTNI) showed significant differences between eventual survival animals and non-survival animals at 4 h after ROSC (109.2 ± 10.7 mmHg vs. 94.8 ± 12.3 mmHg, P=0.048; 100.8 ± 6.9 mmHg vs. 84.4±12.6 mmHg, P=0.011; 1.60 ± 0.13 ug/L vs. 1.75 ± 0.10 ug/L, P=0.046). Mitral valve early-to-late diastolic peak velocity ratio, mitral valve deceleration time recovered 24 h; ejection faction and the summed rest score recovered 48 h after ROSC.
  
  
  CONCLUSIONS
  Cardiac systolic and early active relaxation dysfunctions were reversible within survival animals; cardiac stunning might be potentially adaptive and protective after CPR. The recovery of MAP, CPP, and CTNI could be the indicators for long-term survival after CPR.
authors.affiliation: Hyperbaric Oxygen Department, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. yanglin000719@hotmail.com
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: ChunSheng
authors.initials: C
authors.lastname: Li
authors.forename: ChunJin
authors.initials: C
authors.lastname: Gao
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: XianFei
authors.initials: X
authors.lastname: Ji
authors.forename: ZhiYu
authors.initials: Z
authors.lastname: Su
mesh_terms: D000818:Animals; D001794:Blood Pressure; D016887:Cardiopulmonary Resuscitation; D003326:Coronary Circulation; D006323:Heart Arrest; D006439:Hemodynamics; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D017682:Myocardial Stunning; D013552:Swine; D013997:Time Factors; D014693:Ventricular Fibrillation