title: Lack of prognostic value of immunohistochemical determination of epidermal growth-factor receptors in human prostate-cancer.
abstract: We have investigated whether the expression of Epidermal Growth Factor Receptors (EGF-Rc) evaluated by immunohistochemical technique, may influence the prognosis of patients with prostate cancer. EGF-Rc were positive in 20/76 (26.3%) of tumors. There was no correlation between EGF-Rc and other prognostic factors such as tumor size, Gleason score, metastases at diagnosis, DNA content and S-Phase fraction (SPF). In patients with locally advanced tumors EGF-Rc expression was significantly correlated with the presence of metastases at diagnosis (p=0.038). Both disease-free survival (DFS) and overall survival (OS) did not differ between patients with receptor-positive and receptor-negative tumors. It is concluded that the immunohistochemical localization of EGF-Rc is of limited prognostic value in prostate cancer.
authors.affiliation: UNIV G DANNUNZIO,CATTEDRA ONCOL MED,VIA VESTINI 66,I-66100 CHIETI,ITALY. UNIV G DANNUNZIO,IST ANAT PATOL,I-66100 CHIETI,ITALY. UNIV G DANNUNZIO,UROL CLIN,I-66100 CHIETI,ITALY.
authors.forename: C
authors.initials: C
authors.lastname: Amatetti
authors.forename: D
authors.initials: D
authors.lastname: Angelucci
authors.forename: B
authors.initials: B
authors.lastname: Fiorentino
authors.forename: N
authors.initials: N
authors.lastname: Tinari
authors.forename: P
authors.initials: P
authors.lastname: Distefano
authors.forename: R
authors.initials: R
authors.lastname: Tenaglia
authors.forename: S
authors.initials: S
authors.lastname: Iacobelli
authors.forename: C
authors.initials: C
authors.lastname: Natoli