title: ATPase family AAA domain containing 3A is an anti-apoptotic factor and a secretion regulator of PSA in prostate cancer.
abstract: In order to investigate the clinical value of ATPase family AAA domain containing 3A (ATAD3A), a potential anti-apoptotic factor in prostate cancer (PCa), immunohistochemistry was used to measure ATAD3A expression in pathological specimens from 86 Chinese patients and in 183 tissue-array samples from American patients. The effect of ATAD3A on the expression of prostate specific antigen (PSA) and drug resistance in PCa cell lines was determined by in vitro experiments. ATAD3A was detected in 74 of 86 (86.0%) Chinese specimens and in 145 of 183 (79.2%) American patient samples. No difference was found in ATAD3A expression between these two patient groups. In vitro, silencing of ATAD3A expression reduced PSA secretion and cisplatin resistance, suggesting that ATAD3A was associated with PSA secretion and drug resistance in PCa.
authors.affiliation: Institute of Medicine, Chung-Shan Medical University, Taichung, Taiwan, ROC.
authors.forename: Kuo-Hsuan
authors.initials: KH
authors.lastname: Huang
authors.forename: Kuan-Chih
authors.initials: KC
authors.lastname: Chow
authors.forename: Hui-Wen
authors.initials: HW
authors.lastname: Chang
authors.forename: Tze-Yi
authors.initials: TY
authors.lastname: Lin
authors.forename: Meng-Chih
authors.initials: MC
authors.lastname: Lee
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities; D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000494:pharmacology; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D017430:Prostate-Specific Antigen / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D017434:Protein Structure, Tertiary
chemical_list: C549686:ATAD3A protein, human; D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D017430:Prostate-Specific Antigen; D000251:Adenosine Triphosphatases; D000074183:ATPases Associated with Diverse Cellular Activities; D002945:Cisplatin