title: A case of Good's syndrome: a rare acquired immunodeficiency associated with thymoma.
abstract: The patient was a 76-year-old man who had a prior history of recurrent pneumonia and severe, chronic sinusitis. Computed tomography showed a thymoma, and laboratory results revealed hypogammaglobulinemia. Therefore, Good's Syndrome (GS, rare adult-onset immunodeficiency with thymoma) was diagnosed. To treat his sinusitis, we started the patient on long-term clarithromycin therapy, preoperatively. A thymothymectomy was performed, but the immunological disorder was not resolved. Although standard gamma globulin replacement was not given, his sinusitis symptoms were ameliorated, and he has not had pneumonia since the operation. Long-term macrolide therapy probably plays some role in managing sino-pulmonary infections associated with GS.
authors.affiliation: Fukui Red Cross Hospital, Division of Thoracic Surgery, 2-4-1 Tsukimi, Fukui, Japan. cfaqq207@gmail.com
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kikuchi
authors.forename: Nobuya
authors.initials: N
authors.lastname: Mino
authors.forename: Taku
authors.initials: T
authors.lastname: Okamoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsukura
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirai
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001706:Biopsy; D002908:Chronic Disease; D017291:Clarithromycin / Q000008:administration & dosage; D017074:Common Variable Immunodeficiency / Q000209:etiology* / Q000276:immunology; D006801:Humans; D008297:Male; D009375:Neoplasms, Glandular and Epithelial / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology; D012008:Recurrence; D012852:Sinusitis / Q000188:drug therapy / Q000209:etiology; D013934:Thymectomy; D013945:Thymoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin