title: Evaluation of prosthetic-valved devices by means of numerical simulations.
abstract: The in vivo evaluation of prosthetic device performance is often difficult, if not impossible. In particular, in order to deal with potential problems such as thrombosis, haemolysis, etc., which could arise when a patient undergoes heart valve replacement, a thorough understanding of the blood flow dynamics inside the devices interacting with natural or composite tissues is required. Numerical simulation, combining both computational fluid and structure dynamics, could provide detailed information on such complex problems. In this work, a numerical investigation of the mechanics of two composite aortic prostheses during a cardiac cycle is presented. The numerical tool presented is able to reproduce accurately the flow and structure dynamics of the prostheses. The analysis shows that the vortical structures forming inside the two different grafts do not influence the kinematics of a bileaflet valve or the main coronary flow, whereas major differences are present for the stress status near the suture line of the coronaries to the prostheses. The results are in agreement with in vitro and in vivo observations found in literature.
authors.affiliation: DIMeG and CEMeC, Politecnico di Bari, Via Re David 200, 70125 Bari, Italia.
authors.forename: M D
authors.initials: MD
authors.lastname: de Tullio
authors.forename: G
authors.initials: G
authors.lastname: Pascazio
authors.forename: L
authors.initials: L
authors.lastname: Weltert
authors.forename: R
authors.initials: R
authors.lastname: De Paulis
authors.forename: R
authors.initials: R
authors.lastname: Verzicco
mesh_terms: D006350:Heart Valve Prosthesis; D006801:Humans; D008962:Models, Theoretical