title: Serotonin syndrome due to duloxetine.
abstract: Serotonin syndrome is a toxic condition due to serotoninergic hyperstimulation, which is caused mostly by serotonergic agents either in overdose or in combination. The diagnosis is purely clinical and poorly validated. We described a patient with tremor, mydriatic pupils, clonus, and ataxia after a single dose of duloxetine; on the dosage of admission. Duloxetine belongs to a large class of antidepressants called reuptake inhibitors. The case is presented to emphasize this possible toxicity due to increasing availability of serotonergic agents. It is a complex but easily preventable and recognizable condition. We believe this to be one of the rare reports of serotonin syndrome associated with duloxetine.
authors.affiliation: Department of Neurology, Ankara Research and Training Hospital, Ministry of Health, Ankara, Turkey. drpinargelener@windowslive.com
authors.forename: Pnar
authors.initials: P
authors.lastname: Gelener
authors.forename: Umit
authors.initials: U
authors.lastname: Gorgulu
authors.forename: Gulnihal
authors.initials: G
authors.lastname: Kutlu
authors.forename: Serap
authors.initials: S
authors.lastname: Ucler
authors.forename: Levent Ertugrul
authors.initials: LE
authors.lastname: Inan
mesh_terms: D000328:Adult; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000175:diagnosis*; D013876:Thiophenes / Q000009:adverse effects*
chemical_list: D013876:Thiophenes; D000068736:Duloxetine Hydrochloride