title: Time trend in the surgical therapy of lung cancer.
abstract: BACKGROUND
  The purpose of our study was to clarify results of surgery for non-small cell lung cancer (NSCLC) and its time trends.
  
  
  METHODS
  We retrospectively reviewed our prospective database of patients who underwent surgery for NSCLC between 1998 and 2009 in our institution. Patients were divided into two equal 6-year periods according to the year of surgery (1998-2003 and 2004-2009).
  
  
  RESULTS
  One thousand, four hundred and twelve patients underwent operation for NSCLC. We performed 985 lobectomies with 30-days mortality of 1.8 % and 300 pneumonectomies with 30-days mortality of 5.7 %. Median of survival of all 1412 patients was 4.3 year and 5-year survival was 45 %. The percentage of female patients, lobectomies and adenocarcinomas increased over time, as well as the age of our patients. Outcome improved over time, with significant decrease in a 30-days mortality after pneumonectomy (8.2 % vs 2.3 %, p=0.029). The overall 3-year survival improved in patients with stage III (30 % vs 40 %, p=0.012).
  
  
  CONCLUSIONS
  Outcomes of lung resection for NSCLC improved over time despite a worsening of some elements of preoperative status. The shift in histological distribution was associated with an increasing proportion of patients with stage I, a lower operative mortality and better 3- and 5-year survival. These trends are due to improvement of preoperative evaluation, preoperative and postoperative care (Tab. 1, Fig. 2, Ref. 9). Full Text in free PDF www.bmj.sk.
authors.affiliation: 3rd Department of Surgery, First Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
authors.forename: A
authors.initials: A
authors.lastname: Stolz
authors.forename: P
authors.initials: P
authors.lastname: Pafko
authors.forename: R
authors.initials: R
authors.lastname: Lischke
authors.forename: T
authors.initials: T
authors.lastname: Harustiak
authors.forename: J
authors.initials: J
authors.lastname: Simonek
authors.forename: J
authors.initials: J
authors.lastname: Schutzner
authors.forename: S
authors.initials: S
authors.lastname: Adamek
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000639:trends*