title: Studies for the application of boron neutron capture therapy to the treatment of differentiated thyroid cancer.
abstract: The aim of these studies was to evaluate the possibility of treating differentiated thyroid cancer by BNCT. These carcinomas are well controlled with surgery followed by therapy with (131)I; however, some patients do not respond to this treatment. BPA uptake was analyzed both in vitro and in nude mice implanted with cell lines of differentiated thyroid carcinoma. The boron intracellular concentration in the different cell lines and the biodistribution studies showed the selectivity of the BPA uptake by this kind of tumor.
authors.affiliation: Department of Radiobiology, National Atomic Energy Commission (CNEA), San Martin, Argentina. dagrosa@cnea.gov.ar
authors.forename: A
authors.initials: A
authors.lastname: Dagrosa
authors.forename: M
authors.initials: M
authors.lastname: Carpano
authors.forename: M
authors.initials: M
authors.lastname: Perona
authors.forename: L
authors.initials: L
authors.lastname: Thomasz
authors.forename: S
authors.initials: S
authors.lastname: Nievas
authors.forename: R
authors.initials: R
authors.lastname: Cabrini
authors.forename: G
authors.initials: G
authors.lastname: Juvenal
authors.forename: M
authors.initials: M
authors.lastname: Pisarev
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000378:metabolism; D016754:Boron Neutron Capture Therapy; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D001896:Boron Compounds; D010649:Phenylalanine; C033685:4-boronophenylalanine