title: [Applications of DNA transposons to the study of gene function in mice].
abstract: In the past decade, transposon-mediated insertional mutagenesis has been widely used in mammalian molecular genetics. As a convenient and efficient tool for genetic manipulation, transposon has played an important role in making transgenic animal models, performing gene therapy, and annotating gene function at the cellular level and by animal studies in vivo. This review focuses on the structure, function and latest research progress of DNA transposons applied in mouse genetics.
authors.affiliation: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Mei-Li
authors.initials: ML
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements / Q000235:genetics*; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D004251:DNA Transposable Elements