title: Amplification of the expression of major histocompatibility class-I antigens by inducers of differentiation and gamma interferon in murine and human solid tumor-cell lines.
abstract: Treatment of B16 F10-9 mouse melanoma cell line and RC-29 human renal carcinoma cell line with chemical inducers of differentiation such as sodium butyrate (SB) hexamethylene bisacetamide (HMBA) and L-histidinol significantly increased the expression of major histocompatability complex (MHC) class I antigens. This effect depends on the continued exposure of the cells to these materials. Combined treatment of the B16 F10-9 melanoma cells with recombinant murine gamma interferon and SB increased the expression of MHC class I antigens in a synergistic manner. This effect of chemical inducers of differentiation might be of importance in rendering tumor cells more sensitive to the immune defense mechanisms.
authors.affiliation: BEILINSON MED CTR,ENDOCRINOL LAB,IL-49100 PETAH TIQWA,ISRAEL. BEILINSON MED CTR,INST CANC,IL-49100 PETAH TIQWA,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL. WEIZMANN INST SCI,DEPT CELL BIOL,IL-76100 REHOVOT,ISRAEL.
authors.forename: E
authors.initials: E
authors.lastname: Fenig
authors.forename: J
authors.initials: J
authors.lastname: Nordenberg
authors.forename: H
authors.initials: H
authors.lastname: Lurie
authors.forename: P
authors.initials: P
authors.lastname: Angel
authors.forename: M
authors.initials: M
authors.lastname: Feldman
authors.forename: L
authors.initials: L
authors.lastname: Eisenbach