title: Cell adhesion molecule cadherin-6 function in zebrafish cranial and lateral line ganglia development.
abstract: Cadherins regulate the vertebrate nervous system development. We previously showed that cadherin-6 message (cdh6) was strongly expressed in the majority of the embryonic zebrafish cranial and lateral line ganglia during their development. Here, we present evidence that cdh6 has specific functions during cranial and lateral line ganglia and nerve development. We analyzed the consequences of cdh6 loss-of-function on cranial ganglion and nerve differentiation in zebrafish embryos. Embryos injected with zebrafish cdh6 specific antisense morpholino oligonucleotides (MOs, which suppress gene expression during development; cdh6 morphant embryos) displayed a specific phenotype, including (i) altered shape and reduced development of a subset of the cranial and lateral line ganglia (e.g., the statoacoustic ganglion and vagal ganglion) and (ii) cranial nerves were abnormally formed. These data illustrate an important role for cdh6 in the formation of cranial ganglia and their nerves.
authors.affiliation: Department of Biology, Integrated Bioscience Program, University of Akron, Akron, Ohio, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: M R
authors.initials: MR
authors.lastname: Dalman
authors.forename: S
authors.initials: S
authors.lastname: Sarmah
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: A K
authors.initials: AK
authors.lastname: Hurlbut
authors.forename: M A
authors.initials: MA
authors.lastname: Spencer
authors.forename: L
authors.initials: L
authors.lastname: Pancoe
authors.forename: J A
authors.initials: JA
authors.lastname: Marrs
mesh_terms: D000818:Animals; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D005724:Ganglia / Q000196:embryology / Q000378:metabolism*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D020287:In Situ Nick-End Labeling; D053403:Lateral Line System / Q000196:embryology / Q000378:metabolism*; D017933:Peripheral Nervous System / Q000196:embryology / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D015820:Cadherins; D029961:Zebrafish Proteins; C087310:K cadherin