title: The vertebrate retina: a model for neuronal polarization in vivo.
abstract: The vertebrate retina develops rapidly from a proliferative neuroepithelium into a highly ordered laminated structure, with five distinct neuronal cell types. Like all neurons, these cells need to polarize in appropriate orientations order integrate their neuritic connections efficiently into functional networks. Its relative simplicity, amenability to in vivo imaging and experimental manipulation, as well as the opportunity to study varied cell types within a single tissue, make the retina a powerful model to uncover how neurons polarize in vivo. Here we review the progress that has been made thus far in understanding how the different retinal neurons transform from neuroepithelial cells into mature neurons, and how the orientation of polarization may be specified by a combination of pre-established intrinsic cellular polarity set up within neuroepithelial cells, and extrinsic cues acting upon these differentiating neurons.
authors.affiliation: Department of Physiology, Development and Neuroscience, Cambridge University, Downing Street, Cambridge, United Kingdom.
authors.forename: Owen
authors.initials: O
authors.lastname: Randlett
authors.forename: Caren
authors.initials: C
authors.lastname: Norden
authors.forename: William A
authors.initials: WA
authors.lastname: Harris
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D012160:Retina / Q000502:physiology* / Q000648:ultrastructure; D014714:Vertebrates