title: SNPsyn: detection and exploration of SNP-SNP interactions.
abstract: SNPsyn (http://snpsyn.biolab.si) is an interactive software tool for the discovery of synergistic pairs of single nucleotide polymorphisms (SNPs) from large genome-wide case-control association studies (GWAS) data on complex diseases. Synergy among SNPs is estimated using an information-theoretic approach called interaction analysis. SNPsyn is both a stand-alone C++/Flash application and a web server. The computationally intensive part is implemented in C++ and can run in parallel on a dedicated cluster or grid. The graphical user interface is written in Adobe Flash Builder 4 and can run in most web browsers or as a stand-alone application. The SNPsyn web server hosts the Flash application, receives GWAS data submissions, invokes the interaction analysis and serves result files. The user can explore details on identified synergistic pairs of SNPs, perform gene set enrichment analysis and interact with the constructed SNP synergy network.
authors.affiliation: Faculty of Computer and Information Science, University of Ljubljana, Trzaska cesta 25, SI-1000 Ljubljana, Slovenia. tomaz.curk@fri.uni-lj.si
authors.forename: Tomaz
authors.initials: T
authors.lastname: Curk
authors.forename: Gregor
authors.initials: G
authors.lastname: Rot
authors.forename: Blaz
authors.initials: B
authors.lastname: Zupan
mesh_terms: D002874:Chromosome Mapping; D055106:Genome-Wide Association Study; D020407:Internet; D020641:Polymorphism, Single Nucleotide; D012984:Software