title: Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.
abstract: Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed "click" reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodynamic profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail.
authors.affiliation: School of Chemistry, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Anthony T S
authors.initials: AT
authors.lastname: Lo
authors.forename: Noeris K
authors.initials: NK
authors.lastname: Salam
authors.forename: David E
authors.initials: DE
authors.lastname: Hibbs
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Rutledge
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Todd
mesh_terms: D020856:AT Rich Sequence / Q000235:genetics*; D002151:Calorimetry; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D020862:GC Rich Sequence / Q000235:genetics*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D009429:Netropsin / Q000031:analogs & derivatives* / Q000737:chemistry; D009757:Nylons / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D006571:Heterocyclic Compounds; D008670:Metals; D009757:Nylons; C053654:lexitropsin; C024560:cyclam; D009429:Netropsin; D004247:DNA