title: p-Cresylsulfate and indoxyl sulfate level at different stages of chronic kidney disease.
abstract: Indoxyl sulfate and p-cresylsulfate was associated with poor clinical outcome of uremia. We explored the relationship between the two toxins and renal function in chronic kidney disease (CKD) patients. This study enrolled 103 stable CKD patients (stage 3-5 and hemodialysis (HD) patients). Serum levels of indoxyl sulfate and p-cresylsulfate were measured using ultra performance liquid chromatography. General laboratory results and patient background were also checked. Patients with advanced CKD had higher serum indoxyl sulfate, p-cresylsulfate based on ANOVA test. There were significant correlation between indoxyl sulfate and p-cresylsulfate and serum creatinine after multivariate regression analysis (B=3.59, P<0.01; B=0.93, P=0.04, respectively). In addition, there was a positive correlation between indoxyl sulfate and p-cresylsulfate level (r=0.61, P<0.01). Indoxyl sulfate and p-cresylsulfate level increased gradually while renal function declined and reached the peak at the stage of HD. Serum indoxyl sulfate level was closely associated with p-cresylsulfate level in CKD patients.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Cheng-Jui
authors.initials: CJ
authors.lastname: Lin
authors.forename: Han-Hsiang
authors.initials: HH
authors.lastname: Chen
authors.forename: Chi-Feng
authors.initials: CF
authors.lastname: Pan
authors.forename: Chih-Kuang
authors.initials: CK
authors.lastname: Chuang
authors.forename: Tuen-Jen
authors.initials: TJ
authors.lastname: Wang
authors.forename: Fang-Ju
authors.initials: FJ
authors.lastname: Sun
authors.forename: Chih-Jen
authors.initials: CJ
authors.lastname: Wu
mesh_terms: D015331:Cohort Studies; D003408:Cresols / Q000097:blood*; D005260:Female; D006801:Humans; D007200:Indican / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013463:Sulfuric Acid Esters
chemical_list: D003408:Cresols; D013463:Sulfuric Acid Esters; C408690:4-cresol sulfate; D007200:Indican