title: High-resolution optical coherence tomography imaging in KCNV2 retinopathy.
abstract: OBJECTIVE
  To report novel spectral domain optical coherence tomography (SD-OCT) findings and new mutational data in patients with 'cone dystrophy with supernormal rod electroretinogram', a recessive childhood onset retinal dystrophy consequent upon mutation in the KCNV2 gene.
  
  
  METHODS
  This was a comparative case series study of 12 patients with clinical and/or electrophysiological findings in keeping with KCNV2 mutation. Clinical examination and electrophysiological testing results were reviewed. Fundus photography and autofluorescence imaging were performed. Retinal layer appearance and thickness were evaluated using SD-OCT. The coding region and intron-exon boundaries of KCNV2 were screened by direct sequencing.
  
  
  RESULTS
  Mutations in KCNV2 were detected in all families; five of these changes were novel. Pattern electroretinograms were undetectable and full-field electroretinograms showed findings specific for the disorder. SD-OCT demonstrated bilateral morphological changes, usually confined to the fovea. Four foveal SD-OCT phenotypes were observed: (i) discontinuous inner and outer segment (IS/OS) junction reflectivity (6 patients), (ii) loss of IS/OS line and an optical gap in the foveola (2 patients); (iii) IS/OS junction disruption and profound foveal depth reduction, without optical gap and with preserved retinal pigment epithelium (RPE) complex (2 patients); and (iv) outer retina and RPE complex abnormalities (2 patients). Thinning of the neurosensory retina was observed in all eyes.
  
  
  CONCLUSIONS
  In KCNV2 retinopathy foveal morphological changes are evident on SD-OCT even in the early stages of disease. However, there appears to be a window of opportunity, before marked structural damage has occurred, during which novel therapeutic intervention, such as gene replacement therapy, may rescue retinal function.
authors.affiliation: Moorfields Eye Hospital, 162 City Road, London EC1V 2PD, UK.
authors.forename: Panagiotis I
authors.initials: PI
authors.lastname: Sergouniotis
authors.forename: Graham E
authors.initials: GE
authors.lastname: Holder
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Robson
authors.forename: Michel
authors.initials: M
authors.lastname: Michaelides
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Webster
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Moore
mesh_terms: D000293:Adolescent; D000328:Adult; D003623:Dark Adaptation; D004596:Electroretinography; D005451:Fluorescein Angiography; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010775:Photic Stimulation; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics*; D017949:Retinal Cone Photoreceptor Cells / Q000473:pathology*; D058499:Retinal Dystrophies / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D035781:Siblings; D041623:Tomography, Optical Coherence; D055815:Young Adult
chemical_list: C489610:KCNV2 protein, human; D024642:Potassium Channels, Voltage-Gated