title: Ameliorating effects of Mango (Mangifera indica L.) fruit on plasma ethanol level in a mouse model assessed with H-NMR based metabolic profiling.
abstract: The ameliorating effects of Mango (Mangifera indica L.) flesh and peel samples on plasma ethanol level were investigated using a mouse model. Mango fruit samples remarkably decreased mouse plasma ethanol levels and increased the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase. The (1)H-NMR-based metabolomic technique was employed to investigate the differences in metabolic profiles of mango fruits, and mouse plasma samples fed with mango fruit samples. The partial least squares-discriminate analysis of (1)H-NMR spectral data of mouse plasma demonstrated that there were clear separations among plasma samples from mice fed with buffer, mango flesh and peel. A loading plot demonstrated that metabolites from mango fruit, such as fructose and aspartate, might stimulate alcohol degradation enzymes. This study suggests that mango flesh and peel could be used as resources for functional foods intended to decrease plasma ethanol level after ethanol uptake.
authors.affiliation: College of Pharmacy (WCU), Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: So-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Somi
authors.initials: S
authors.lastname: K Cho
authors.forename: Tae-Sun
authors.initials: TS
authors.lastname: Min
authors.forename: Yujin
authors.initials: Y
authors.lastname: Kim
authors.forename: Seung-Ok
authors.initials: SO
authors.lastname: Yang
authors.forename: Hee-Su
authors.initials: HS
authors.lastname: Kim
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Hyun
authors.forename: Hana
authors.initials: H
authors.lastname: Kim
authors.forename: Young-Suk
authors.initials: YS
authors.lastname: Kim
authors.forename: Hyung-Kyoon
authors.initials: HK
authors.lastname: Choi