title: New cytotoxic metabolites from a deep-sea-derived fungus, Phialocephala sp., strain FL30r.
abstract: Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep-sea sediment-derived fungus, Phialocephala sp. Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 (IC(50) values of 11.5±1.4, 0.1±0.1, and 0.2±0.01 μM, resp.) and K562 (IC(50) values of 22.9±0.8, 4.8±0.3 and 22.4±0.9 μM, resp.) cell lines.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China.
authors.forename: De-Hai
authors.initials: DH
authors.lastname: Li
authors.forename: Sheng-Xin
authors.initials: SX
authors.lastname: Cai
authors.forename: Tian-Jiao
authors.initials: TJ
authors.lastname: Zhu
authors.forename: Feng-Ping
authors.initials: FP
authors.lastname: Wang
authors.forename: Xiang
authors.initials: X
authors.lastname: Xiao
authors.forename: Qian-Qun
authors.initials: QQ
authors.lastname: Gu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003512:Cyclohexanones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; D003512:Cyclohexanones