title: How do you RUN on?
abstract: RUN domain is present in several proteins related to the functions of Rap and Rab family GTPases. Accumulating evidence supports the hypothesis that RUN domain-containing proteins act as a component of vesicle traffic and might be responsible for an interaction with a filamentous network linked to actin cytoskeleton or microtubules. That is to say, on one hand, RUN domains associate with Rab or Rap family proteins, on the other hand, they also might interact with motor proteins such as kinesin or myosin via intervention molecules. In this review, we summarize the background and current status of RUN domain research with an emphasis on the interaction between RUN domain and motor proteins with respect to the vesicle traffic on filamentous network.
authors.affiliation: Department of Environmental Health Science, Nara Women's University, Kita-Uoya Nishimachi, Nara, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kitagishi
authors.forename: Naoko
authors.initials: N
authors.lastname: Okumura
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Murakami
authors.forename: Yuri
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsuda
mesh_terms: D001692:Biological Transport; D020409:Molecular Motor Proteins / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D020691:rab GTP-Binding Proteins / Q000737:chemistry / Q000502:physiology*; D020668:rap GTP-Binding Proteins / Q000737:chemistry / Q000502:physiology*
chemical_list: D020409:Molecular Motor Proteins; D020691:rab GTP-Binding Proteins; D020668:rap GTP-Binding Proteins