title: Eukaryotic type translation initiation factor 2: structure-functional aspects.
abstract: Translation initiation factor 2 (IF2) is one of key components of the translation initiation system in living cells. In bacteria IF2 is a multidomain monomeric protein, while in eukaryotic and archaean cells e/aIF2 is heterotrimer (αβγ). Data, including our own, on eukaryotic type translation initiation factor 2 (e/aIF2) structure and functioning are presented. There are also new data on initiation factors eIF5 and eIF2B that directly interact with eIF2 and control its participation in nucleotide exchange.
authors.affiliation: Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. esmail@vega.protres.ru
authors.forename: E A
authors.initials: EA
authors.lastname: Stolboushkina
authors.forename: M B
authors.initials: MB
authors.lastname: Garber
mesh_terms: D000818:Animals; D015852:Eukaryotic Initiation Factor-2 / Q000737:chemistry* / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D012358:RNA, Transfer, Met / Q000378:metabolism; D054679:Ribosome Subunits, Small / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D015852:Eukaryotic Initiation Factor-2; D012333:RNA, Messenger; D012358:RNA, Transfer, Met