title: Estimation of liver T₂ in transfusion-related iron overload in patients with weighted least squares T₂ IDEAL.
abstract: MRI imaging of hepatic iron overload can be achieved by estimating T(2) values using multiple-echo sequences. The purpose of this work is to develop and clinically evaluate a weighted least squares algorithm based on T(2) Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation (IDEAL) technique for volumetric estimation of hepatic T(2) in the setting of iron overload. The weighted least squares T(2) IDEAL technique improves T(2) estimation by automatically decreasing the impact of later, noise-dominated echoes. The technique was evaluated in 37 patients with iron overload. Each patient underwent (i) a standard 2D multiple-echo gradient echo sequence for T(2) assessment with nonlinear exponential fitting, and (ii) a 3D T(2) IDEAL technique, with and without a weighted least squares fit. Regression and Bland-Altman analysis demonstrated strong correlation between conventional 2D and T(2) IDEAL estimation. In cases of severe iron overload, T(2) IDEAL without weighted least squares reconstruction resulted in a relative overestimation of T(2) compared with weighted least squares.
authors.affiliation: Department of Radiology, Stanford University Medical School, Stanford, California, USA.
authors.forename: Shreyas S
authors.initials: SS
authors.lastname: Vasanawala
authors.forename: Huanzhou
authors.initials: H
authors.lastname: Yu
authors.forename: Ann
authors.initials: A
authors.lastname: Shimakawa
authors.forename: Michael
authors.initials: M
authors.lastname: Jeng
authors.forename: Jean H
authors.initials: JH
authors.lastname: Brittain
mesh_terms: D000328:Adult; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D019190:Iron Overload / Q000209:etiology* / Q000473:pathology*; D016018:Least-Squares Analysis; D008099:Liver / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult