title: Design and synthesis of bile acid-peptide conjugates linked via triazole moiety.
abstract: A conjugation of bile acids with peptides via Cu(I)-catalyzed click chemistry has been described. Novel bile acid-peptide conjugates linked via a 1,2,3-triazole moiety based on cholic, deoxycholic and lithocholic acid derivatives were synthesized using Cu(I)-catalyzed 1,3-dipolar cycloaddition ("click" reaction). It was shown that up to three peptide fragments can be attached to a central steroid core, thus forming complex three-dimensional polyconjugate structures, which can find important applications in biochemistry, medicinal chemistry, and coordination chemistry.
authors.affiliation: Department of Chemistry, Moscow State University, 119991, Leninskie Gory, Moscow, Russia.
authors.forename: Nadezhda V
authors.initials: NV
authors.lastname: Sokolova
authors.forename: Gennadij V
authors.initials: GV
authors.lastname: Latyshev
authors.forename: Nikolay V
authors.initials: NV
authors.lastname: Lukashev
authors.forename: Valentine G
authors.initials: VG
authors.lastname: Nenajdenko
mesh_terms: D001647:Bile Acids and Salts / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D001647:Bile Acids and Salts; D010455:Peptides; D014230:Triazoles; D003300:Copper