title: Electrical stimulation of peripheral nerves induces optical responses via skeletal muscle kinematics.
abstract: We have previously reported an optical response in human subjects occurring at 100 ms following electrical stimulation of peripheral nerves. In the present study, an animal model has been created to directly investigate the myogenic components of the signal. In addition, experiments have been performed in human subjects to investigate the signal's neuroanatomical specificity, sensitivity to muscle motion, and spatial and spectral features. The results of this work suggest that the observed optical signal derives from stimulus-induced motion associated with muscle contraction and likely contains myological information of clinical value.
authors.affiliation: Boston University School of Medicine, Boston MA, USA 02118.
authors.forename: M Kelley
authors.initials: MK
authors.lastname: Erb
authors.forename: Debbie K
authors.initials: DK
authors.lastname: Chen
authors.forename: Angelo
authors.initials: A
authors.lastname: Sassaroli
authors.forename: Sergio
authors.initials: S
authors.lastname: Fantini
authors.forename: Peter R
authors.initials: PR
authors.lastname: Bergethon