title: 3FunMap: full-sib family functional mapping of dynamic traits.
abstract: BACKGROUND
  Functional mapping that embeds the developmental mechanisms of complex traits shows great power to study the dynamic pattern of genetic effects triggered by individual quantitative trait loci (QTLs). A full-sib family, produced by crossing two heterozygous parents, is characteristic of uncertainties about cross-type at a locus and linkage phase between different loci. Integrating functional mapping into a full-sib family requires a model selection procedure capable of addressing these uncertainties. 3FunMap, written in VC++ 6.0, provides a flexible and extensible platform to perform full-sib functional mapping of dynamic traits. Functions in the package encompass linkage phase determination, marker map construction and the pattern identification of QTL segregation, dynamic tests of QTL effects, permutation tests and numerical simulation. We demonstrate the features of 3FunMap through real data analysis and computer simulation.
  
  
  BACKGROUND
  http://statgen.psu.edu/software.
authors.affiliation: Key Laboratory of Forest Genetics and Biotechnology of Ministry of Education, Nanjing Forestry University, Nanjing 210037, China.
authors.forename: Chunfa
authors.initials: C
authors.lastname: Tong
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Jisen
authors.initials: J
authors.lastname: Shi
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
mesh_terms: D002874:Chromosome Mapping / Q000379:methods; D003198:Computer Simulation; D005819:Genetic Markers; D008957:Models, Genetic; D032107:Populus / Q000235:genetics; D040641:Quantitative Trait Loci; D035781:Siblings; D012984:Software
chemical_list: D005819:Genetic Markers