title: Porcine model of early onset scoliosis based on animal growth created with posterior mini-invasive spinal offset tethering: a preliminary report.
abstract: Several models of scoliosis were developed in the past 10 years. In most of them, deformations are induced in old animals and required long time observation period and a chest wall ligation ± resection. The purpose of the study was to create a scoliosis model with a size similar to an early onset scoliosis and an important growth potential without chest wall injuring. An original offset implant was fixed posteriorly and connected with a cable in seven (6 + 1 control) one-month-old Landrace pigs. The mean initial spinal length (T1-S1) was 25 cm and the mean weight was 9 kg. After 2 months observation, spinal deformities were assessed with a three dimension stereographic analysis. In four animals, the cable was sectioned and the deformities followed-up for next 2 months. No post-operative complication was observed. Mean weight growth was 10 kg/month and mean spine lengthening (T1-S1) was 7 cm/month. In 2 months, we obtained structural scoliotic curves with vertebral and disk wedging which were maximal at the apex of the curve. Mean frontal and sagittal Cobb angles was 45°. Chest wall associated deformities were similar to those observed in scoliotic deformities and were correlated to spinal deformities (p = 0.03). The cable section resulted in a partial curve regression influenced by disk elasticity and could probably be influenced by gravity loads (Decrease of the Cobb angle of 30% in the sagittal plane and 45% in the frontal plane). According to the results, the model creates a structural scoliosis and chest wall deformity that is similar to an early onset scoliosis. The spinal deformities were obtained quickly, and were consistent between animals in term of amount and characteristic.
authors.affiliation: Service de Chirurgie Orthopédique Pédiatrique, Université Paris Descartes, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, 149, rue de Sèvres, 75015 Paris, France. thierry.odent@nck.aphp.fr
authors.forename: Th
authors.initials: T
authors.lastname: Odent
authors.forename: Th
authors.initials: T
authors.lastname: Cachon
authors.forename: B
authors.initials: B
authors.lastname: Peultier
authors.forename: J
authors.initials: J
authors.lastname: Gournay
authors.forename: E
authors.initials: E
authors.lastname: Jolivet
authors.forename: C
authors.initials: C
authors.lastname: Elie
authors.forename: H
authors.initials: H
authors.lastname: Abdoul
authors.forename: E
authors.initials: E
authors.lastname: Viguier
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D012600:Scoliosis / Q000209:etiology* / Q000601:surgery; D013131:Spine / Q000254:growth & development* / Q000601:surgery; D013552:Swine