title: [Features of chronic pancreatitis in the elderly patients].
abstract: The aim of this study was to determine the severity of the exocrine and endocrine insufficiency of the pancreas, HC composition and state of homeostasis in the elderly patients. Was obsercved 76 patients with CP (46 females, 30 males), of whom 20 patients diagnosed alcoholic pancreatitis (AP) aged 30 to 55 years. At 26 patients was marked biliary pancreatitis (BP), age of patients was 35-60 years and at 30 was found involutional pancreatitis (IP) from 60 to 74 years, 15 people (with no signs of lesions of the gastrointestinal tract) consisted the control group. The diagnosis of CP was made on the basis of clinical data, laboratory and instrumental investigations. Depending on the etiology of chronic pancreatitis was revealed a different degree of impairment of exocrine and endocrine functions of pancreas. These changes were more pronounced in patients with AP, which depended on the severity of the disease and the presence of complications. In duodenal bile of patients was significantly progressive decrease in the total content of the HC, which depended on the reduction of the total content of the conjugates. Revealed a qualitative change in HC composition may reduce absorption of exogenous cholesterol in the intestine of patients with CP, and is one of the reasons affecting the state of the exocrine pancreas. These changes are especially pronounced in patients with IP. All patients with CP were observed on blood hypercoagulation, which was accompanied by a decrease in the overall constant blood clotting, increasing content of F, an increase in the index of coagulation and clot elasticity. Especially pronounced these changes were in patients with complicated disease and the elderly patients.
authors.forename: L V
authors.initials: LV
authors.lastname: Vinokurova
authors.forename: N I
authors.initials: NI
authors.lastname: Iashina
authors.forename: S G
authors.initials: SG
authors.lastname: Shustova
authors.forename: A V
authors.initials: AV
authors.lastname: Gubina
authors.forename: E V
authors.initials: EV
authors.lastname: Tkachenko
authors.forename: T V
authors.initials: TV
authors.lastname: Nilova
mesh_terms: D000328:Adult; D000367:Age Factors; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007515:Islets of Langerhans / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D046790:Pancreas, Exocrine / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D050500:Pancreatitis, Chronic / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology
chemical_list: D002784:Cholesterol