title: Study on changes of IGF-I and leptin levels in serum and placental tissue of prceclampsia patients and their associativity.
abstract: OBJECTIVE
  To explore the changes of IGF-I and leptin levels in serum and placental tissue of prceclampsia patients, and to study the associativity of IGF-I and leptin at the onset and in the development of prceclampsia further.
  
  
  METHODS
  The levels of IGF-I and leptin in serum and placental tissue of 80 patients with prceclampsia and 50 normal pregnancy were detected with ELISA and immunohistochemistry.
  
  
  RESULTS
  The serum IGF-I level of mild and severe prceclampsia was significantly lower than that of normal pregnancy group (P<0.05), and the serum leptin level of mild and severe prceclampsia was significantly lower than that of normal pregnancy group (P<0.05). The serum IGF-I level in severe prceclampsia group was lower than that in mild prceclampasia and the serum leptin level in severe prceclampsia was higher than that in mild prceclampsia ( P<0.05). There were significantly difference in the expression of IGF-I and leptin among normal pregnancy group, mild and severe prceclampsia group (P<0.05).
  
  
  CONCLUSIONS
  The level of IGF-I and leptin may be involved in the pathogenesis and development of prceclampsia and can be a index to test the prognosis of prceclampsia patient.
authors.affiliation: Obstetric Department, the Third Xiangya Hospotal of Central South University, Changsha, China.
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Peng
authors.forename: Min
authors.initials: M
authors.lastname: Xue
authors.forename: Ai-bin
authors.initials: AB
authors.lastname: Xia
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D020738:Leptin / Q000032:analysis / Q000097:blood*; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000469:parasitology*; D011247:Pregnancy; D011379:Prognosis; D055815:Young Adult
chemical_list: D020738:Leptin; D007334:Insulin-Like Growth Factor I