title: Molecular characterization of scl rearrangements in T-cell all from India and egypt.
abstract: SCL gene rearrangement is the most common molecular lesion (25%) identified so far in T-cell acute lymphoblastic leukemia (T-ALL). Since the frequency of T-ALL appears to be relatively higher in developing countries, we wished to determine as to what fraction of T-ALL from this population harbor SCL rearrangements. We show in this study that although the overall frequency of SCL/SIL rearrangements in T-ALL is similar to the Western countries this is at the expense of increased type A rearrangements. Whether the paucity of type B rearrangements reflects a difference in disease etiology in this part of the world is to be determined.
authors.affiliation: TATA MEM HOSP,BOMBAY,INDIA. NATL CANC INST,CAIRO,EGYPT.
authors.forename: K
authors.initials: K
authors.lastname: Bhatia
authors.forename: G
authors.initials: G
authors.lastname: Spangler
authors.forename: S
authors.initials: S
authors.lastname: Advani
authors.forename: A
authors.initials: A
authors.lastname: Kamel
authors.forename: N
authors.initials: N
authors.lastname: Hamdy
authors.forename: R
authors.initials: R
authors.lastname: Iyer
authors.forename: P
authors.initials: P
authors.lastname: Aplan
authors.forename: I
authors.initials: I
authors.lastname: Magrath