title: Correlation between physical anomaly and behavioral abnormalities in Down syndrome.
abstract: OBJECTIVE
  The minor physical anomaly (MPA) is believed to reflect abnormal development of the CNS. The aim is to find incidence of MPA and its behavioral correlates in Down syndrome and to compare these findings with the other causes of intellectual disability and normal population.
  
  
  METHODS
  One-hundred and forty intellectually disabled people attending a tertiary care set-up and from various NGOs are included in the study. The age-matched group from normal population was also studied for comparison. MPA are assessed by using Modified Waldrop scale and behavioral abnormality by Diagnostic assessment scale for severely handicapped (DASH II scale).
  
  
  RESULTS
  The Down syndrome group had significantly more MPA than other two groups and most of the MPA is situated in the global head region. There is strong correlation (P < 0.001) between the various grouped items of Modified Waldrop scale. Depression subscale is correlated with anomalies in the hands (P < 0.001), feet and Waldrop total items (P < 0.005). Mania item of DASH II scale is related with anomalies around the eyes (P < 0.001). Self-injurious behavior and total Waldrop score is negatively correlated with global head.
  
  
  CONCLUSIONS
  Down syndrome group has significantly more MPA and a pattern of correlation between MPA and behavioral abnormalities exists which necessitates a large-scale study.
authors.affiliation: Department of Psychiatry, Calcutta National Medical College, Kolkata, India.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Bhattacharyya
authors.forename: Debasish
authors.initials: D
authors.lastname: Sanyal
authors.forename: Krishna
authors.initials: K
authors.lastname: Roy
authors.forename: Sumita
authors.initials: S
authors.lastname: Bhattacharyya