title: Influence of carbohydrate biological vectors on the two-photon resonance of porphyrin oligomers.
abstract: We propose a spectroscopic study of π-conjugated porphyrin dimers and a triphenylamine centered trimer bearing monoethyleneglycol-peracetylated α-mannose targeting moieties, which were synthesized for application to two-photon absorption photodynamic therapy (2PA-PDT). The collected spectroscopic data are explained through comparison with previous results obtained on similar nonvectorized analogues. It appears that the different shifts and variations in linear and nonlinear absorption and emission bands are mainly due to an increased twist between the tetrapyrrolic units. The 2PA properties of the triphenylamine-centered trimer have been studied, and two fluorescence emission bands are observed that seem to originate from two different 2PA excitation pathways. These results have important implication for the design of new vectorized photosensitizers for 2PA-PDT.
authors.affiliation: UMR 176 CNRS/Institut Curie, Institut Curie, Bât 110, Centre Universitaire, Université Paris-Sud, F-91405 Orsay, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Hammerer
authors.forename: Sylvain
authors.initials: S
authors.lastname: Achelle
authors.forename: Patrice
authors.initials: P
authors.lastname: Baldeck
authors.forename: Philippe
authors.initials: P
authors.lastname: Maillard
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Teulade-Fichou
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D019281:Dimerization; D008665:Metalloporphyrins / Q000737:chemistry*; D015394:Molecular Structure; D010778:Photochemotherapy; D011522:Protons
chemical_list: D000814:Aniline Compounds; D002241:Carbohydrates; D008665:Metalloporphyrins; D011522:Protons