title: Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.
abstract: Recent advances in liquid chromatography and mass spectrometry have enabled the highly parallel, quantitative measurement of metabolites within a cell and the ability to trace their biochemical fates. In Mycobacterium tuberculosis (Mtb), these advances have highlighted major gaps in our understanding of central carbon metabolism (CCM) that have prompted fresh interpretations of the composition and structure of its metabolic pathways and the phenotypes of Mtb strains in which CCM genes have been deleted. High-throughput screens have demonstrated that small chemical compounds can selectively inhibit some enzymes of Mtb's CCM while sparing homologs in the host. Mtb's CCM has thus emerged as a frontier for both fundamental and translational research.
authors.affiliation: Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. kyr9001@med.cornell.edu
authors.forename: Kyu Y
authors.initials: KY
authors.lastname: Rhee
authors.forename: Luiz Pedro Sorio
authors.initials: LP
authors.lastname: de Carvalho
authors.forename: Ruslana
authors.initials: R
authors.lastname: Bryk
authors.forename: Sabine
authors.initials: S
authors.lastname: Ehrt
authors.forename: Joeli
authors.initials: J
authors.lastname: Marrero
authors.forename: Sae Woong
authors.initials: SW
authors.lastname: Park
authors.forename: Dirk
authors.initials: D
authors.lastname: Schnappinger
authors.forename: Aditya
authors.initials: A
authors.lastname: Venugopal
authors.forename: Carl
authors.initials: C
authors.lastname: Nathan
mesh_terms: D000900:Anti-Bacterial Agents; D053898:Biosynthetic Pathways; D002244:Carbon / Q000378:metabolism*; D019295:Computational Biology; D019143:Evolution, Molecular; D005798:Genes, Bacterial; D023281:Genomics; D055432:Metabolomics; D009169:Mycobacterium tuberculosis / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D002244:Carbon