title: [Enterovirus infection as a risk factor of acute coronary syndrome and its complications].
abstract: Antigens of enteroviruses were detected quantitatively in the modified complement-binding reaction in blood samples from 102 of the 208 (49%) patients with ACS, in coronary artery tissues from 23 of 24 and heart from 51 of 94 (54.3%) patients with MI who died from cardiogenic shock and/or cardiac rupture. The relative level of enterovirus antigen (RLEVA) in the blood of patients with MI complicated and uncomplicated by cardiogenic shock and/or cardiac rupture was 0.42 +/- 0.04 and 0.29 +/- 0.02 arbitrary units respectively (p = 0.032) compared with 0.21 +/- 0.07 in patients with unstable angina (UA) (p = 0.0001). RLEVA in patients with UA was significantly lower than in those with uncomplicated MI (p < 0.011). RLEVA in necrotized myocardial areas after death from cardiogenic shock (0.54 +/- 0.18) and/or cardiac rupture (0.46 +/- 0.15) was higher than outside MI zones (0.30 +/- 0.14 and 0.26 +/- 0.10 respectively) (p < 0.01). RLEVA in coronary vessels feeding the necrotic zones of patients with MI complicated by cardiogenic shock (0.44 +/- 0.18) was higher (p = 0.03) than in the vessel feeding tissues outside the MI zone (0.29 +/- 0.19). It is concluded that enterovirus infection is a factor of ACS; it is directly involved in its pathogenesis and promotes the development of cardiogenic shock and/or cardiac rupture.
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Plotkin
authors.forename: V L
authors.initials: VL
authors.lastname: Voronel'
authors.forename: M A
authors.initials: MA
authors.lastname: Timoshina
authors.forename: Z A
authors.initials: ZA
authors.lastname: Zaripova
authors.forename: E A
authors.initials: EA
authors.lastname: Murina
authors.forename: N N
authors.initials: NN
authors.lastname: Khromov-Borisov
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology / Q000821:virology*; D000368:Aged; D000369:Aged, 80 and over; D000956:Antigens, Viral / Q000097:blood; D002353:Carrier State / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D004770:Enterovirus / Q000276:immunology / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006341:Heart Rupture / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012770:Shock, Cardiogenic / Q000453:epidemiology / Q000821:virology*
chemical_list: D000956:Antigens, Viral