title: B Lymphocyte commitment program is driven by the proto-oncogene c-Myc.
abstract: c-Myc, a member of the Myc family of transcription factors, is involved in numerous biological functions including the regulation of cell proliferation, differentiation, and apoptosis in various cell types. Of all of its functions, the role of c-Myc in cell differentiation is one of the least understood. We addressed the role of c-Myc in B lymphocyte differentiation. We found that c-Myc is essential from early stages of B lymphocyte differentiation in vivo and regulates this process by providing B cell identity via direct transcriptional regulation of the ebf-1 gene. Our data show that c-Myc influences early B lymphocyte differentiation by promoting activation of B cell identity genes, thus linking this transcription factor to the EBF-1/Pax-5 pathway.
authors.affiliation: Departamento de Inmunología y Oncología, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Cientificas, E-28049 Madrid, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Vallespinós
authors.forename: David
authors.initials: D
authors.lastname: Fernández
authors.forename: Lorena
authors.initials: L
authors.lastname: Rodríguez
authors.forename: Josué
authors.initials: J
authors.lastname: Alvaro-Blanco
authors.forename: Esther
authors.initials: E
authors.lastname: Baena
authors.forename: Maitane
authors.initials: M
authors.lastname: Ortiz
authors.forename: Daniela
authors.initials: D
authors.lastname: Dukovska
authors.forename: Dolores
authors.initials: D
authors.lastname: Martínez
authors.forename: Ana
authors.initials: A
authors.lastname: Rojas
authors.forename: Miguel R
authors.initials: MR
authors.lastname: Campanero
authors.forename: Ignacio
authors.initials: I
authors.lastname: Moreno de Alborán
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation / Q000276:immunology*; D005786:Gene Expression Regulation / Q000276:immunology*; D051379:Mice; D051757:PAX5 Transcription Factor / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000276:immunology; D014158:Transcription, Genetic
chemical_list: C081976:EBF1 protein, human; C000715470:MAS1 protein, human; C489428:Myc protein, mouse; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc; D015534:Trans-Activators; D014157:Transcription Factors