title: Quantification of airway deposition of intact and fragmented pollens.
abstract: Although pollen is one of the most widespread agents that can cause allergy, its airway transport and deposition is far from being fully explored. The objective of this study was to characterize the airway deposition of pollens and to contribute to the debate related to the increasing number of asthma attacks registered after thunderstorms. For the quantification of the deposition of inhaled pollens in the airways computer simulations were performed. Our results demonstrated that smaller and fragmented pollens may penetrate into the thoracic airways and deposit there, supporting the theory that fragmented pollen particles are responsible for the increasing incidence of asthma attacks following thunderstorms. Pollen deposition results also suggest that children are the most exposed to the allergic effects of pollens. Finally, pollens between 0.5 and 20 μm deposit more efficiently in the lung of asthmatics than in the healthy lung, especially in the bronchial region.
authors.affiliation: GlaxoSmithKline, Budapest, Hungary.
authors.forename: Alpár
authors.initials: A
authors.lastname: Horváth
authors.forename: Imre
authors.initials: I
authors.lastname: Balásházy
authors.forename: Arpád
authors.initials: A
authors.lastname: Farkas
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Sárkány
authors.forename: Werner
authors.initials: W
authors.lastname: Hofmann
authors.forename: Aladár
authors.initials: A
authors.lastname: Czitrovszky
authors.forename: Erik
authors.initials: E
authors.lastname: Dobos
mesh_terms: D000393:Air Pollutants / Q000032:analysis*; D001249:Asthma / Q000453:epidemiology; D003198:Computer Simulation; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D008168:Lung / Q000502:physiology; D009010:Monte Carlo Method; D010316:Particle Size; D011058:Pollen; D011891:Rain; D012307:Risk Factors; D013269:Stochastic Processes
chemical_list: D000393:Air Pollutants