title: Epidemiology, risk factors, and overall survival rate of laryngeal cancer in Songklanagarind Hospital.
abstract: OBJECTIVE
  To study epidemiology, risk factors and overall survival rate of patients with laryngeal cancer.
  
  
  METHODS
  A chart review of the patients diagnosed with laryngeal cancer in Songklanagarind Hospital over the past 10 years was performed.
  
  
  RESULTS
  Two hundred eighty nine patient cases were reviewed, in which 106 patients were diagnosed with supraglottic cancer 180 with glottic cancer and three with subglottic cancer. The majority of the patients was male, active smokers, alcohol consumers and had a histology showing squamous cell carcinoma. Disease characteristics indicated that most cases of supraglottic cancer were in a locally advanced stage (84.4%), whereas most patients with glottic cancer were diagnosed with early stage (61.3%). Hoarseness was the most common presenting symptom. Regarding the complete response rate, glottic cancer was superior to supraglottic cancer. For glottic cancer treatments, surgery alone or primary radiation showed good 5-year overall survival rates with no difference in modality results (87.5% versus 83.2%). In supraglottic cancer treatments and contrary to glottic cancer surgery with postoperative radiation improved the 5-year overall survival rate in comparison with primary radiation alone (52.2% versus 39.2%).
  
  
  CONCLUSIONS
  Primary radiation or surgery alone is suitable treatments for early stage laryngeal cancer especially in glottic cancer whereas surgery with postoperative radiation should be the treatment for advanced stage laryngeal cancer.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand. dtanadec@medicine.psu.ac.th
authors.forename: Tanadech
authors.initials: T
authors.lastname: Dechaphunkul
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006784:Hospitals, Teaching; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects; D011795:Surveys and Questionnaires; D015996:Survival Rate; D013785:Thailand / Q000453:epidemiology; D016896:Treatment Outcome