title: Preoperative chemoimmunotherapy with Carboplatin, epidoxorubicin, 5-Fluorouracil and alpha-2b interferon in locally advanced inoperable gastric-cancer.
abstract: Twenty-six patients with locally advanced, inoperable gastric cancer were treated with carboplatin, epidoxorubicin, 5-fluorouracil (FEP) plus alpha 2b interferon. Total gastrectomy was performed in patients achieving clinical complete or partial response. The overall response rate after neoadjuvant chemotherapy was 67%. In 13/15 patients undergoing surgery no residual tumor was evident after resection. After a median follow-up of 14 months, 4/13 disease-free patients have relapsed. The median survival time is 13 months for all patients, and 19 months for disease-free patients; in four patients survival time exceeds twenty-four months. Our multimodality program is effective in locally advanced gastric cancer and warrants further evaluation.
authors.affiliation: UNIV CAGLIARI,IST MED INTERNA,I-09100 CAGLIARI,ITALY. IST MED LEGALE AM,I-20129 MILAN,ITALY. IST TUMORI NAPOLI,DIV ENDOCRINOL ONCOL,I-80131 NAPLES,ITALY. OSPED VICO EQUENSE,NAPLES,ITALY. OSPED INCURABILI,I-80100 NAPLES,ITALY.
authors.forename: R
authors.initials: R
authors.lastname: Iaffaioli
authors.forename: F
authors.initials: F
authors.lastname: Caponigro
authors.forename: A
authors.initials: A
authors.lastname: Tortoriello
authors.forename: G
authors.initials: G
authors.lastname: Facchini
authors.forename: L
authors.initials: L
authors.lastname: Bucci
authors.forename: G
authors.initials: G
authors.lastname: Scaramellino
authors.forename: G
authors.initials: G
authors.lastname: Frasci
authors.forename: V
authors.initials: V
authors.lastname: Vallefuoco
authors.forename: G
authors.initials: G
authors.lastname: Persico