title: A novel small-cell lung carcinoma-specific DNA-binding activity related to the transcription factor ap-1.
abstract: A novel TRE-binding protein complex was detected specifically in 12 out of 13 small cell lung carcinoma (SCLC) cell lines. This complex was characterised by a lower electrophoretic mobility than the 'ubiquitous' complex present in all other carcinoma cell lines analysed. As shown by UV-crosslinking and South-Western blotting, the SCLC-specific complex contains a protein with an apparent M(r) > 100 kD, which is far bigger than all Fos and Jun proteins described to date. In addition, the DNA-binding specificity of this complex is different from the specificity of the 'ubiquitous' complex or a Fos/Jun heterodimer.
authors.affiliation: UNIV MARBURG,INST MOLEK BIOL & TUMORFORSCH,EMIL MANNKOPFF STR 2,W-3550 MARBURG,GERMANY. UNIV MARBURG,ZENTRUM INNERE MED,W-3550 MARBURG,GERMANY.
authors.forename: J
authors.initials: J
authors.lastname: Adamkiewicz
authors.forename: M
authors.initials: M
authors.lastname: Behn
authors.forename: S
authors.initials: S
authors.lastname: Brusselbach
authors.forename: K
authors.initials: K
authors.lastname: Havemann
authors.forename: R
authors.initials: R
authors.lastname: Muller