title: [The relationships among raphe magnus nucleus, locus coeruleus and dorsal motor nucleus of vagus in the descending regulation of gastric motility].
abstract: OBJECTIVE
  To explore the interrelationship among dorsal motor nucleus of the vagus (DMV), locus coeruleus (LC) and raphe magnus nucleus (NRM) in the mechanism of the descending regulation on gastric motility, which may constitute a parasympathetic local circuit, work as a neural center of gastric modulation in brainstem.
  
  
  METHODS
  Using nucleus location, electric stimulation and lesion, together with microinjection, and recording the inter-gastric pressure.
  
  
  RESULTS
  (1) LC stimulation could inhibit the gastric motility significantly (P < 0.01), DMV lesion weaken this effect, while blocking the a receptor on DMV could reverse the effect. (2) NRM stimulation reduced the amplitude of gastric constriction (P < 0.01), DMV lesion could abolish the effect, but blocking the 5-HT2A receptor on DMV depressed the gastric motility heavily (P < 0.01) like NRM stimulation. While LC lesion could abolish the effect of NRM stimulation, and microinjection of ritanserin into LC could likewise abolish it.
  
  
  CONCLUSIONS
  (1) LC inhibit the gastric motility via a receptor in DMV, and meanwhile may excite it through 5-HT2A receptor in DMV, these two ways work together to keeping the gastric motility amplitude normally. (2) NRM inhibit the gastric motility via 5-HT2A receptor in LC.
authors.affiliation: Department of Life Science, Shanxi Normal University, Xi' an 710062, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Qiao
authors.forename: Shu-Cheng
authors.initials: SC
authors.lastname: An
authors.forename: Chang
authors.initials: C
authors.lastname: Xu
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000502:physiology; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014630:Vagus Nerve / Q000502:physiology*