title: Local control of metastatic sites with radiation therapy in metastatic Ewing sarcoma and rhabdomyosarcoma.
abstract: Approximately 20% of children with Ewing sarcoma (EWS) and rhabdomyosarcoma (RMS) present with metastatic disease at initial diagnosis. Overall, the outcome is poor, with an event-free survival of < 20%. Local control at metastatic sites has not been previously reported. We reviewed control of metastatic sites in children with EWS and RMS that received curative intent radiation therapy to each metastatic site. In 13 children, at a median follow-up of 18 months, a single local failure was seen. Toxicity was minimal. Our data suggest that radiation therapy is effective and tolerable in children with metastatic EWS and RMS.
authors.affiliation: Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado, USA. arthur.liu@ucdenver.edu
authors.forename: Arthur K
authors.initials: AK
authors.lastname: Liu
authors.forename: Michelle
authors.initials: M
authors.lastname: Stinauer
authors.forename: Edythe
authors.initials: E
authors.lastname: Albano
authors.forename: Brian
authors.initials: B
authors.lastname: Greffe
authors.forename: Tiffany
authors.initials: T
authors.lastname: Tello
authors.forename: Kelly
authors.initials: K
authors.lastname: Maloney
mesh_terms: D000293:Adolescent; D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy*; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy*; D015996:Survival Rate