title: Bone morphogenic protein: an elixir for bone grafting--a review.
abstract: Bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor beta superfamily. This literature review focuses on the molecular biology of BMPs, their mechanism of action, and subsequent applications. It also discusses uses of BMPs in the fields of dentistry and orthopedics, research on methods of delivering BMPs, and their role in tissue regeneration. BMP has positive effects on bone grafts, and their calculated and timely use with other growth factors can provide extraordinary results in fractured or nonhealing bones. Use of BMP introduces new applications in the field of implantology and bone grafting. This review touches on a few unknown facts about BMP and this ever-changing field of research to improve human life.
authors.affiliation: St Vincent Charity Hospital, Cleveland, OH, USA. shahprasun@hotmail.com
authors.forename: Prasun
authors.initials: P
authors.lastname: Shah
authors.forename: Louis
authors.initials: L
authors.lastname: Keppler
authors.forename: James
authors.initials: J
authors.lastname: Rutkowski
mesh_terms: D052004:Bone Morphogenetic Protein Receptors / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation / Q000502:physiology*; D004337:Drug Carriers; D006801:Humans; D015398:Signal Transduction; D051785:Smad Proteins / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins; D004337:Drug Carriers; D051785:Smad Proteins; D052004:Bone Morphogenetic Protein Receptors