title: Ethyl 4-{1-[(2,4-dinitro-phen-yl)hydrazono]eth-yl}-5-(2-naphthyl-methoxy-meth-yl)isoxazole-3-carboxyl-ate.
abstract: The title compound, C(26)H(23)N(5)O(8), was prepared and its structure investigated to further develop a working hypothesis for the essential binding pharmacophore for ligands of the System Xc- transporter [Patel et al. (2004 ▶). Neuropharmacology, 46, 273-284]. The hydrazone group displays an E geometry and the isoxazole double bond and C=N group of the hydrazone are in an s-cis relationship. The secondary amino NH group forms an intra-molecular N-H⋯O hydrogen bond to a ring nitro group. There is a dihedral angle of 44.27 (5)° between the isoxazole plane and the hydrazone group plane.
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Natale
authors.forename: Monica I
authors.initials: MI
authors.lastname: Szabon-Watola
authors.forename: Brendan
authors.initials: B
authors.lastname: Twamley
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Bridges
authors.forename: Sarjubhai
authors.initials: S
authors.lastname: Patel
authors.forename: Trideep
authors.initials: T
authors.lastname: Rajale