title: Blindness in dogs with pituitary dependent hyperadrenocorticism: relationship with glucose, cortisol and triglyceride concentration and with ophthalmic blood flow.
abstract: Pituitary dependent hyperadrenocorticism (PDH) shows a high morbidity and blindness is one of its complications. Compression of the optic chiasm (OC) by the hypophysis adenoma is one of the causes. Another cause could be due to vascular and metabolic alterations of the PDH. Out of a total of 70 dogs with confirmed diagnosis of PDH, 12/70 showed blindness. In only 2/12 the OC was compromised. Electroretinography in dogs without the OC being compromised showed altered A and B wave patterns. Ophthalmological Doppler showed an alteration of the blood flow only in blind dogs without OC compression. Cortisol concentrations (Co), triglycerides (Tg) and glycaemia (G) were greater in 10 dogs with non-compressive blindness vs. dogs with conserved vision. Loss of vision correlated with the increase in these variables. Blindness in dogs with PDH would be related to changes in retinal blood flow, associated to higher Co, Tg and G concentrations.
authors.affiliation: Clínica Médica de Pequeños Animales-HEMV, U. Endocrinología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, (1427) Av. Chorroarin 280, Argentina.
authors.forename: M F
authors.initials: MF
authors.lastname: Cabrera Blatter
authors.forename: A
authors.initials: A
authors.lastname: del Prado
authors.forename: M F
authors.initials: MF
authors.lastname: Gallelli
authors.forename: E
authors.initials: E
authors.lastname: D'Anna
authors.forename: J
authors.initials: J
authors.lastname: Ivanic
authors.forename: M
authors.initials: M
authors.lastname: Esarte
authors.forename: D D
authors.initials: DD
authors.lastname: Miceli
authors.forename: N V
authors.initials: NV
authors.lastname: Gómez
authors.forename: V A
authors.initials: VA
authors.lastname: Castillo
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D000818:Animals; D001766:Blindness / Q000662:veterinary*; D001786:Blood Glucose / Q000502:physiology*; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D012171:Retinal Vessels / Q000502:physiology; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D006854:Hydrocortisone