title: Ovarian preservation in a young patient with Gorlin syndrome and multiple bilateral ovarian masses.
abstract: OBJECTIVE
  To report a case of bilateral ovarian fibromas and ovarian leiomyomas in a young patient with Gorlin syndrome and to highlight issues of fertility preservation, ovarian conservation, and preimplantation genetic diagnosis in this population.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A 15-year-old female patient with Gorlin syndrome and bilateral ovarian masses.
  
  
  METHODS
  Ultrasound, magnetic resonance imaging, hormone analysis, and laparotomy with resection of ovarian fibromas.
  
  
  METHODS
  Preservation of ovarian function, pathologic diagnosis.
  
  
  RESULTS
  Our patient represented an adolescent case of bilateral ovarian fibromas and leiomyomas in Gorlin syndrome presenting with menstrual irregularities. She was managed surgically with resection of the lesions and conservation of normal ovarian tissue.
  
  
  CONCLUSIONS
  In Gorlin syndrome, ovarian fibromas are a common clinical manifestation. Patients with ovarian involvement may present with complex gynecologic needs and may have decreased fertility potential. Careful surgical management, follow-up, and counseling on options for future fertility should be offered to all patients.
authors.affiliation: University of Pennsylvania Medical Center, Department of Obstetrics and Gynecology, Reproductive Research Unit, 3701 Market Street, Suite 810, Philadelphia, PA 19104, USA. cmorse@mail.med.upenn.edu
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Morse
authors.forename: Janet F
authors.initials: JF
authors.lastname: McLaren
authors.forename: Darshan
authors.initials: D
authors.lastname: Roy
authors.forename: Evan S
authors.initials: ES
authors.lastname: Siegelman
authors.forename: Virginia A
authors.initials: VA
authors.lastname: Livolsi
authors.forename: Clarisa R
authors.initials: CR
authors.lastname: Gracia
mesh_terms: D000293:Adolescent; D001478:Basal Cell Nevus Syndrome / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D010053:Ovary / Q000000981:diagnostic imaging / Q000601:surgery*; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*