title: Regulation of pml messenger-RNA expression in human breast-carcinoma cells.
abstract: We examined the mRNA expression profile of PML, a novel nuclear protein recently characterized from acute promyelocytic leukemia (APL) blast cells, in a number of breast carcinoma cell lines. PML mRNA was found to be differentially expressed among the cell lines examined. A correlation of borderline significance between PML mRNA expression and the proliferative capacity of the cell Lines was noted. Serum stimulation significantly elevated the PML mRNA levels in the T47D and MDA-MB-231 cells. These results would suggest that PML may function as a positive regulator of cellular proliferation in breast carcinoma cells.
authors.affiliation: UNIV MARYLAND,SCH MED,CTR CANC,BALTIMORE,MD 21201. UNIV MARYLAND,SCH MED,DEPT MED,DIV ONCOL,BALTIMORE,MD 21201. VET ADM MED CTR,BALTIMORE,MD 21201.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Sheikh
authors.forename: Z
authors.initials: Z
authors.lastname: Shao
authors.forename: S
authors.initials: S
authors.lastname: Lanzkron
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Fontana