title: [What has the long clinical experience of PPIs taught us about their putative side effects?].
abstract: In addition to drug interactions (e.g. with clopidogrel), PPI therapy has been suggested to have--particularly in long term--undesirable effects on gastric epithelium, infection risk, bone strength, and vitamin and mineral levels in serum. Analyses of the literature indicate that existing data in this regard are based on studies that are susceptible to bias and confounding. Significant interaction between PPI therapy and clopidogrel is controversial. PPIs can be regarded as safe, and should not be denied to patients who are likely to benefit from them.
authors.affiliation: HYKS, medisiininen tulosyksikkö, gastroenterologian klinikka, Peijaksen sairaala, HUS.
authors.forename: Markku
authors.initials: M
authors.lastname: Nissinen
mesh_terms: D015519:Bone Density / Q000187:drug effects; D000077144:Clopidogrel; D004347:Drug Interactions; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D007239:Infections / Q000209:etiology; D008903:Minerals / Q000097:blood; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D012307:Risk Factors; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives; D014815:Vitamins / Q000097:blood
chemical_list: D008903:Minerals; D010975:Platelet Aggregation Inhibitors; D054328:Proton Pump Inhibitors; D014815:Vitamins; D000077144:Clopidogrel; D013988:Ticlopidine