title: A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles.
abstract: Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benz[g]indole.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China. lxfok@zju.edu.cn
authors.forename: Xufeng
authors.initials: X
authors.lastname: Lin
authors.forename: Zhenjun
authors.initials: Z
authors.lastname: Mao
authors.forename: Xixiang
authors.initials: X
authors.lastname: Dai
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
authors.forename: Yanguang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000098:Acetophenones / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D006038:Glyoxylates / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D000588:Amines; D006038:Glyoxylates; D007211:Indoles; D011725:Pyridines; D011758:Pyrroles; C013190:phenacyl bromide; C030374:indole; C031150:glyoxylic acid; C023666:pyridine