title: Histone deacetylases as regulators of inflammation and immunity.
abstract: Histone deacetylases (HDACs) remove an acetyl group from lysine residues of target proteins to regulate cellular processes. Small-molecule inhibitors of HDACs cause cellular growth arrest, differentiation and/or apoptosis, and some are used clinically as anticancer drugs. In animal models, HDAC inhibitors are therapeutic for several inflammatory diseases, but exacerbate atherosclerosis and compromise host defence. Loss of HDAC function has also been linked to chronic lung diseases in humans. These contrasting effects might reflect distinct roles for individual HDACs in immune responses. Here, we review the current understanding of innate and adaptive immune pathways that are regulated by classical HDAC enzymes. The objective is to provide a rationale for targeting (or not targeting) individual HDAC enzymes with inhibitors for future immune-related applications.
authors.affiliation: The University of Queensland, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, Queensland 4072, Australia.
authors.forename: Melanie R
authors.initials: MR
authors.lastname: Shakespear
authors.forename: Maria A
authors.initials: MA
authors.lastname: Halili
authors.forename: Katharine M
authors.initials: KM
authors.lastname: Irvine
authors.forename: David P
authors.initials: DP
authors.lastname: Fairlie
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Sweet
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use; D006655:Histone Deacetylases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases