title: Create a translational medicine knowledge repository--research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: how will they avoid relearning old lessons?
abstract: Pharmaceutical industry consolidation and overall research downsizing threatens the ability of companies to benefit from their previous investments in translational research as key leaders with the most knowledge of the successful use of biomarkers and translational pharmacology models are laid off or accept their severance packages. Two recently published books may help to preserve this type of knowledge but much of this type of information is not in the public domain. Here we propose the creation of a translational medicine knowledge repository where companies can submit their translational research data and access similar data from other companies in a precompetitive environment. This searchable repository would become an invaluable resource for translational scientists and drug developers that could speed and reduce the cost of new drug development.
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Littman
authors.forename: Francesco M
authors.initials: FM
authors.lastname: Marincola
mesh_terms: D000047:Academies and Institutes / Q000191:economics / Q000458:organization & administration; D001709:Biotechnology / Q000191:economics* / Q000458:organization & administration; D019992:Databases as Topic; D055808:Drug Discovery / Q000191:economics / Q000458:organization & administration; D004345:Drug Industry / Q000191:economics* / Q000458:organization & administration; D006273:Health Facility Merger; D006801:Humans; D019359:Knowledge; D020416:Outsourced Services / Q000191:economics* / Q000458:organization & administration; D020415:Personnel Downsizing / Q000191:economics / Q000458:organization & administration*; D011361:Professional Competence; D057170:Translational Research, Biomedical / Q000191:economics* / Q000458:organization & administration