title: Release of epidermal growth-factor transforming growth-factor-alpha by ovarian-tumors in-vitro.
abstract: EGF-like activity was measured in media from 3-hour incubations of ovarian tissue from 27 patients with normal postmenopausal ovaries, malignant or benign epithelial tumours. EGF-like activity in the medium was measured using a radioreceptor assay. Malignant tumour tissue released significantly more EGF/TGF-alpha than benign tissues and aneuploid carcinomas more than diploid carcinomas. In spite of varying amounts of tumour cells there was a strong correlation in EGF/TCF-alpha release from the different tissue samples of each patient suggesting paracrine rather than autocrine regulation. The level of EGF-like activity may be a feature of the patient rather than of the tumour cells.
authors.affiliation: UMEA UNIV,DEPT GYNAECOL ONCOL,UMEA,SWEDEN. UMEA UNIV,DEPT OBSTET & GYNAECOL,UMEA,SWEDEN. UMEA UNIV,DEPT PHYSIOL,S-90187 UMEA,SWEDEN. UMEA UNIV,DEPT PATHOL,S-90187 UMEA,SWEDEN. KAROLINSKA INST,DEPT MED RADIAT BIOL,STOCKHOLM,SWEDEN.
authors.forename: M
authors.initials: M
authors.lastname: Ridderheim
authors.forename: A
authors.initials: A
authors.lastname: Andersson
authors.forename: S
authors.initials: S
authors.lastname: Cajander
authors.forename: B
authors.initials: B
authors.lastname: Tribukait
authors.forename: U
authors.initials: U
authors.lastname: Stendahl
authors.forename: T
authors.initials: T
authors.lastname: Backstrom