title: Invivo control of tumor-growth with the association of ionidamine with radiation and or hyperthermia.
abstract: The effect of lonidamine (LND) in association with fractionated doses of radiation and/or hyperthermia on tumor growth has been evaluated. The results may be summarized as follows: (i) the fractionation of the radiation dose, in spite of the higher dose delivered (20 Gy) does not increase tumor growth delay when compared to that obtained with a single irradiation treatment. A similar behaviour was also found when the fractionated irradiation was associated with LND. (ii) Hyperthermia is less effective than radiation in controlling tumor growth, but its effect is potentiated by LND although to a lesser extent that with radiation. (iii) LND delivered together with hyperthermia and radiation arrests tumor growth, and leads to the disappearance of the tumor in 75% of mice. The possible mechanisms underlying these effects are discussed.
authors.affiliation: REGINA ELENA INST CANC RES,CTR EXPTL RES,CELL METAB & PHARMACOKINET LAB,VIA MESSI ORO 156,I-00158 ROME,ITALY. ENEA,DEPT BIOL & HEALTHY EFFECTS,I-00060 ROME,ITALY. REGINA ELENA INST CANC RES,CTR EXPTL RES,MED PHYS & EXPERT SYST LAB,I-00158 ROME,ITALY.
authors.forename: A
authors.initials: A
authors.lastname: Cividalli
authors.forename: F
authors.initials: F
authors.lastname: Gentile
authors.forename: L
authors.initials: L
authors.lastname: Begnozzi
authors.forename: L
authors.initials: L
authors.lastname: Chiatti
authors.forename: M
authors.initials: M
authors.lastname: Benassi
authors.forename: A
authors.initials: A
authors.lastname: Floridi