title: Hepatoid adenocarcinoma of the ureter: unusual case presenting hepatic and ovarian metastases.
abstract: Hepatoid adenocarcinoma is a rare neoplasm, which has a striking morphologic similarity to hepatocarcinoma. It has been described in different organs, the most common are stomach, lung, and pancreas. In some cases, it is characterized by high serum levels of α-fetoprotein. This tumor has a pattern similar to the hepatocarcinoma. The typical features are a combination of histopathologic aspects of solid nests and trabecular structures of polygonal atypical cells with eosinophil and granular cytoplasm and immunohistochemical expression of α-fetoprotein and of carcinoembryonic antigen in half of cases. Here, we report the case of an old female patient affected by hepatoid adenocarcinoma of the ureter with ovarian, small intestine, and hepatic involvement. We discuss the clinical aspects, the morphologic features, and the immunoistochemical staining useful for differential diagnosis.
authors.affiliation: Division of Pathology, Department of Critical Care Medicine and Surgery, University Hospital Careggi, University of Florence, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Rotellini
authors.forename: Luca
authors.initials: L
authors.lastname: Messerini
authors.forename: Niceta
authors.initials: N
authors.lastname: Stomaci
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Raspollini
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D005260:Female; D050990:GATA3 Transcription Factor / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007421:Intestine, Small / Q000473:pathology*; D016256:Lewis X Antigen / Q000378:metabolism; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary*; D008565:Membrane Proteins / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000473:pathology / Q000556:secondary*; D014513:Ureter / Q000473:pathology*
chemical_list: C081876:CKAP4 protein, human; D050990:GATA3 Transcription Factor; D016256:Lewis X Antigen; D008565:Membrane Proteins