title: Chemoprevention of respiratory-tract neoplasia in the hamster by oltipraz, alone and in combination.
abstract: Two doses of oltipraz (300, 600 mg/kg diet) and alpha-difluoromethylornithine DFMO; 1600, 3200 mg/kg diet), alone and in combinations with N-(4-hydroxyphenyl) retinamide (4-HPR; 98, 196 mg/kg diet) and/or beta-carotene (3, 1.5 mg; sc, 2x/week), were investigated for prevention of hamster respiratory carcinogenesis. After 25 weeks, only high dose oltipraz (-100%) inhibited the incidence of DEN-induced (17.8 mg/kg BW, sc, 2x/week, 20 weeks) bronchial carcinomas when given alone. Low dose oltipraz (-34%, n.s.) synergistically decreased carcinoma incidence in combinations with 4-HPR (-80%), beta-carotene (-90%) or both (-100%). Other effective combinations were low dose DFMO + beta-carotene (-64%) and high dose DFMO with 4-HPR (-56%), beta-carotene (-63%) or both (-67%).
authors.affiliation: IIT,CHICAGO,IL 60616. NCI,CHEMOPREVENT INVEST STUDIES BRANCH,BETHESDA,MD 20892. CSS ASSOCIATES,PALO ALTO,CA 94301.
authors.forename: R
authors.initials: R
authors.lastname: Moon
authors.forename: K
authors.initials: K
authors.lastname: Rao
authors.forename: C
authors.initials: C
authors.lastname: Detrisac
authors.forename: G
authors.initials: G
authors.lastname: Kelloff
authors.forename: V
authors.initials: V
authors.lastname: Steele
authors.forename: L
authors.initials: L
authors.lastname: Doody