title: [Adhesive strength of a β-tricalcium phosphate-enriched bone adhesive].
abstract: BACKGROUND
  This investigation describes experimental tests of the biomechanical features of a new resorbable bone adhesive based on methacrylate-terminated oligolactides enhanced with osteoconductive β-tricalcium phosphate.
  
  
  METHODS
  51 New Zealand white rabbits were randomised to an adhesive group (n = 29) and a control group (n = 22). An extra-articular bone cylinder was taken from the proximal tibia, two stripes of adhesive were applied and the cylinders were replanted. After 10 and 21 days, 3 and 12 months tibial specimens were harvested and the cylinder pull-out test was performed with a servo-hydraulic machine. Additionally the pull-out force was evaluated with the bone-equivalent Ebazell® after 5, 10 and 360 minutes in 14 specimens each.
  
  
  RESULTS
  Average pull-out forces in the adhesive group were 28 N after 10 days (control: 57 N), 155 N after 21 days (216 N), 184 N after 3 months (197 N) and 205 N after 12 months (185 N). Investigations with Ebazell® showed almost identical pull-out forces after 5 min, 15 min and 360 min. Adhesive forces were as high as 125 N/cm (2) of adhesive surface and more than 1200 N/g of adhesive mass.
  
  
  CONCLUSIONS
  The adhesive investigated here has a very good primary adhesive power, compared to the literature data, achieved after only 5 minutes. Even in moist surroundings the adhesive capacity remains sufficient. The adhesive has to prove its resorptive properties in further investigations and in first line its medium-term and long-lasting biocompatibility. Furthermore, biomechanical features will have to be compared to those of conventional fixation techniques.
authors.affiliation: Die Institutsangaben sind am Ende des Beitrags gelistet. ralf.kraus@chiru.med.uni-giessen.de
authors.forename: R
authors.initials: R
authors.lastname: Kraus
authors.forename: F
authors.initials: F
authors.lastname: Peters
authors.forename: A
authors.initials: A
authors.lastname: Geck
authors.forename: K S
authors.initials: KS
authors.lastname: Lips
authors.forename: M
authors.initials: M
authors.lastname: Obert
authors.forename: C
authors.initials: C
authors.lastname: Röder
authors.forename: M
authors.initials: M
authors.lastname: Schnabelrauch
authors.forename: R
authors.initials: R
authors.lastname: Schnettler
authors.forename: C
authors.initials: C
authors.lastname: Heiss
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001843:Bone Cements; D016025:Bone Transplantation; D002130:Calcium Phosphates; D054893:Cone-Beam Computed Tomography; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D066298:In Vitro Techniques; D016348:Osseointegration / Q000502:physiology; D013718:Tensile Strength; D013977:Tibia / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate