title: [SDHB expression in Warthin's tumour].
abstract: BACKGROUND
  Succinic dehydrogenase subunit B (SDHB) is an enzyme belonging to the mitochondrial complex II. The aim of this study is to analyse SDHB expression in a series of Warthin's tumours, studying its relationship with oncocytic changes, constantly present in this form of tumour.
  
  
  METHODS
  In resection tumour specimens from a series of ten Warthin's tumours (all from the parotid gland), immunohistochemical expression of SDHB was analysed using a commercially-available monoclonal antibody.
  
  
  RESULTS
  The Warthin's tumours studied affected 10 men (mean age: 64.2 yrs, range 40-80), all with smoking habits, and 2 with metachronous bilateral involvement. Two patients presented associated urothelial carcinoma. Our SDHB study showed marked reactivity (++/+++) in all cases in the oncocytic epithelial component and also in striated duct cytoplasm (+) from non-tumorous parotid tissue. Expression was not influenced by age, smoking intensity or bilateral character. One of the tumours showed squamous metaplasia foci with SDHB-negativity at this level.
  
  
  CONCLUSIONS
  Due to the constant and intense SDHB reactivity in oncocytic cells in our observations, oncocytic changes are not considered to be associated with defective enzyme activity in the mitochondrial complex II. Strong SDHB reactivity is an additional marker of oncocytic changes in Warthin's tumour. Neither of these facts has been described previously.
authors.affiliation: Departamento de Estomatología, Universidad de Valencia, Valencia, España. vera_fra@gva.es
authors.forename: Beatriz
authors.initials: B
authors.lastname: Vera-Sirera
authors.forename: Judith
authors.initials: J
authors.lastname: Pérez-Rojas
authors.forename: Cecilia
authors.initials: C
authors.lastname: López-Valdivia
authors.forename: Enrique
authors.initials: E
authors.lastname: Jiménez
authors.forename: Diego
authors.initials: D
authors.lastname: Collado-Martín
authors.forename: Francisco
authors.initials: F
authors.lastname: Vera-Sempere
mesh_terms: D000235:Adenolymphoma / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000096:biosynthesis*
chemical_list: C108095:SDHB protein, human; D013385:Succinate Dehydrogenase