title: [Pulmonary epithelioid hemangioendothelioma: a clinicopathological analysis].
abstract: OBJECTIVE
  To report 3 cases of pulmonary epithelioid haemangioendothelioma (PEH) and therefore to improve the understanding of this tumor.
  
  
  METHODS
  The clinical pathological features of 3 cases of PEH were described and related literatures were reviewed.
  
  
  RESULTS
  The etiology of this rare disease remained unknown. Symptoms were scanty and usually mild. Chest radiograph or computed tomography usually revealed multiple bilateral pulmonary nodules. Histologically, crown-like clusters of epithelioid tumor cells or spindle cells were filled in the alveoli at the periphery of the tumor nodules, while the central part of the nodules contained myxoid to hyaline matrix. Tumor cells generally lacked pleomorphism, mitotic activity and necrosis. They were immunohistochemically positive for CD(31) and CD(34). CK staining was positive in some cases. There was no effective treatment for this disease and its prognosis was unpredictable.
  
  
  CONCLUSIONS
  PEH is a low grade malignancy and represents a distinct clinical pathological entity. It is rare and often misdiagnosed as other pulmonary diseases.
authors.affiliation: Department of Pathology of General Hospital of Guangzhou Military Area, China.
authors.forename: Qiu-lin
authors.initials: QL
authors.lastname: Liao
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Chen
authors.forename: Zhuo-cai
authors.initials: ZC
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Ri-quan
authors.initials: RQ
authors.lastname: Lai
mesh_terms: D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult