title: Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens.
abstract: The generation of an effective immune response against an infection while also limiting tissue damage requires a delicate balance between pro- and anti-inflammatory responses. Interleukin-10 (IL-10) has potent immunosuppressive effects and is essential for regulation of immune responses. However, the immunosuppressive properties of IL-10 can also be exploited by pathogens to facilitate their own survival. In this minireview, we discuss the role of IL-10 in modulating intracellular bacterial, fungal, and parasitic infections. Using information from several different infection models, we bring together and highlight some common pathways for IL-10 regulation and function that cannot be fully appreciated by studies of a single pathogen.
authors.affiliation: Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Cyktor
authors.forename: Joanne
authors.initials: J
authors.lastname: Turner
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity*; D005658:Fungi / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D057131:Immune Evasion; D007108:Immune Tolerance; D016753:Interleukin-10 / Q000276:immunology*; D010271:Parasites / Q000276:immunology* / Q000472:pathogenicity*
chemical_list: D016753:Interleukin-10