title: Allergy to methyldibromoglutaronitrile/phenoxyethanol (Euxyl k 400): regulatory issues, epidemiology, clinical characteristics, and management.
abstract: Methyldibromoglutaronitrile/phenoxyethanol (Euxyl K 400) is a preservative found in both personal care products and industrial sources. Although Euxyl K 400 initially appeared to have low sensitizing potential, increased prevalence of contact allergy to Euxyl K 400 led to regulatory intervention. This review summarizes the history, epidemiology, and management of contact allergy to Euxyl K 400. Issues related to patch-test preparations are also discussed.
authors.affiliation: Department of Dermatology, University of Minnesota School of Medicine, Minneapolis, USA.
authors.forename: Angela E
authors.initials: AE
authors.lastname: Aakhus
authors.forename: Erin M
authors.initials: EM
authors.lastname: Warshaw
mesh_terms: D000818:Animals; D003257:Consumer Product Safety / Q000331:legislation & jurisprudence; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D005026:Ethylene Glycols / Q000009:adverse effects* / Q000737:chemistry; D005060:Europe / Q000453:epidemiology; D006168:Guinea Pigs; D006801:Humans; D009570:Nitriles / Q000009:adverse effects* / Q000737:chemistry; D010328:Patch Tests; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects* / Q000737:chemistry; D014481:United States / Q000453:epidemiology
chemical_list: D005026:Ethylene Glycols; D009570:Nitriles; D011310:Preservatives, Pharmaceutical; C005398:phenoxyethanol; C039411:1,2-dibromo-2,4-dicyanobutane