title: Interaction between MAK-V protein kinase and synaptopodin.
abstract: MAK-V protein kinase (also known as HUNK) was discovered more than decade ago but its functions and molecular mechanisms of action still remain mostly unknown. In an attempt to associate MAK-V with particular chains of molecular events, we searched for proteins interacting with the C-terminal domain of MAK-V protein kinase. We identified synaptopodin as a protein interaction partner for MAK-V and confirmed this interaction in various ways. Because synaptopodin is important for dendritic spine formation and plays a role in synaptic plasticity, our results might have significant impact on future studies for understanding the role of MAK-V in cells of the nervous system.
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. skalin@rambler.ru
authors.forename: S V
authors.initials: SV
authors.lastname: Kalinichenko
authors.forename: P N
authors.initials: PN
authors.lastname: Vikhreva
authors.forename: I V
authors.initials: IV
authors.lastname: Korobko
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D013058:Mass Spectrometry; D051379:Mice; D008840:Microfilament Proteins / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D014018:Tissue Distribution; D020798:Two-Hybrid System Techniques
chemical_list: D008840:Microfilament Proteins; C503968:Synpo protein, mouse; D011494:Protein Kinases; C417729:Hunk protein, mouse; D017346:Protein Serine-Threonine Kinases