title: The effect of selective serotonin re-uptake inhibitors on the risk of myocardial infarction in a cohort of patients with depression.
abstract: OBJECTIVE
  To evaluate whether selective serotonin re-uptake inhibitor (SSRI) exposure influences the risk of myocardial infarction (MI) in patients with depression.
  
  
  METHODS
  This study included 693 patients with MI (cases) and 2772 controls. Conditional logistic regression was used to calculate the odds ratio (OR).
  
  
  RESULTS
  SSRI exposure may be associated with a reduced MI risk (OR = 0.77, 95% CI 0.57, 1.03). However, reduced risk was only observed with longer term use (OR = 0.73, 95% CI 0.53, 1.00) and not with shorter term use (OR = 1.15, 95% CI: 0.65, 2.05).
  
  
  CONCLUSIONS
  Only longer term use of SSRIs was associated with reduced MI risk, suggesting that other mechanisms, besides an acute anti-platelet effect, may reduce MI risk.
authors.affiliation: Center for Clinical Epidemiology and Biostatistics and Cardiovascular Division at the Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA. stevek@mail.med.upenn.edu
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Kimmel
authors.forename: Hedi
authors.initials: H
authors.lastname: Schelleman
authors.forename: Jesse A
authors.initials: JA
authors.lastname: Berlin
authors.forename: David W
authors.initials: DW
authors.lastname: Oslin
authors.forename: Rachel B
authors.initials: RB
authors.lastname: Weinstein
authors.forename: Judith L
authors.initials: JL
authors.lastname: Kinman
authors.forename: William H
authors.initials: WH
authors.lastname: Sauer
authors.forename: James D
authors.initials: JD
authors.lastname: Lewis
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D016022:Case-Control Studies; D015331:Cohort Studies; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced*; D016017:Odds Ratio; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017367:Selective Serotonin Reuptake Inhibitors