title: Cutaneous adverse reactions to fluoroquinolones.
abstract: BACKGROUND
  To date, even though there are some large studies on adverse reactions related to fluoroquinolones, there is no comprehensive study focusing on cutaneous adverse drug reactions associated with their use.
  
  
  OBJECTIVE
  To demonstrate the pattern of cutaneous reaction related to the administration of each type of fluoroquinolone and to study the cross-sensitivity between various types of fluoroquinolones.
  
  
  METHODS
  Voluntary reports of any adverse events associated with fluoroquinolone use as reported from January 2004 to December 2008 and obtained from the Adverse Drug Reaction Center, Siriraj Hospital, Thailand, were reviewed.
  
  
  RESULTS
  Among 166,736 patients who had been treated with fluoroquinolones, the prevalences of adverse reaction and cutaneous adverse reaction were 0.13% and 0.09%, respectively. The prevalence of cutaneous reaction to individual fluoroquinolones varies between 0.04% and 0.37%. One hundred fifty-one subjects were enrolled. Most cutaneous reactions were attributed to ciprofloxacin (n = 93), and the most frequent adverse cutaneous reaction seen was maculopapular rash (39.7%). Thirteen cases (8.6%) involved a previous history of fluoroquinolone hypersensitivity; among these, 15.4% had cross-reactivity potential.
  
  
  CONCLUSIONS
  These data suggest that individual fluoroquinolones are responsible for different types and frequencies of cutaneous reactions, with some potentiality of cross-reactivity between different generations.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Adverse Drug Reaction Center, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Kanokvalai
authors.initials: K
authors.lastname: Kulthanan
authors.forename: Leena
authors.initials: L
authors.lastname: Chularojanamontri
authors.forename: Araya
authors.initials: A
authors.lastname: Manapajon
authors.forename: Naruemon
authors.initials: N
authors.lastname: Dhana
authors.forename: Kowit
authors.initials: K
authors.lastname: Jongjarearnprasert
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D024841:Fluoroquinolones / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013785:Thailand / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones