title: Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response.
authors.affiliation: Catalan Institute of Oncology (ICO), and Girona Biomedical Research Institute (IDIBGI), Catalonia, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Vazquez-Martin
authors.forename: Cristina
authors.initials: C
authors.lastname: Oliveras-Ferraros
authors.forename: Sílvia
authors.initials: S
authors.lastname: Cufí
authors.forename: Begoña
authors.initials: B
authors.lastname: Martin-Castillo
authors.forename: Javier A
authors.initials: JA
authors.lastname: Menendez
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D064447:Checkpoint Kinase 2; D004249:DNA Damage / Q000187:drug effects / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D004789:Enzyme Activation / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008687:Metformin / Q000494:pharmacology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; D008687:Metformin; D064447:Checkpoint Kinase 2; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; C578634:CHEK2 protein, human; D017346:Protein Serine-Threonine Kinases