title: Method for phenotypic detection of extended-spectrum beta-lactamases in enterobacter species in the routine clinical setting.
abstract: In 271 Enterobacter blood culture isolates from 12 hospitals, extended-spectrum beta-lactamase (ESBL) prevalence varied between 0% and 30% per hospital. High prevalence was associated with dissemination, indicating the potential relevance of infection control measures. Screening with cefepime or Vitek 2, followed by a cefepime/cefepime-clavulanate Etest, was an accurate strategy for ESBL detection in Enterobacter isolates (positive predictive value, 100%; negative predictive value, 99%).
authors.affiliation: Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands. j.cohenstuart@umcutrecht
authors.forename: James Cohen
authors.initials: JC
authors.lastname: Stuart
authors.forename: Bram
authors.initials: B
authors.lastname: Diederen
authors.forename: Nashwan
authors.initials: N
authors.lastname: Al Naiemi
authors.forename: Ad
authors.initials: A
authors.lastname: Fluit
authors.forename: Niek
authors.initials: N
authors.lastname: Arents
authors.forename: Steven
authors.initials: S
authors.lastname: Thijsen
authors.forename: Bart
authors.initials: B
authors.lastname: Vlaminckx
authors.forename: Johan W
authors.initials: JW
authors.lastname: Mouton
authors.forename: Maurine
authors.initials: M
authors.lastname: Leverstein-van Hall
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology; D019411:Clinical Laboratory Techniques / Q000379:methods*; D004754:Enterobacter / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D011237:Predictive Value of Tests; D001618:beta-Lactamases / Q000096:biosynthesis*; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases