title: A clinical study on the effects and mechanism of xuebijing injection in severe pneumonia patients.
abstract: OBJECTIVE
  To observe the effects of Xuebijing Injection in patients with severe pneumonia, and to explore the mechanism.
  
  
  METHODS
  Eighty cases of severe pneumonia are randomly assigned to the Xuebijing treatment (forty cases) and the control group (forty cases), with the same routine therapy provided in both groups. Clinical effective rates, inflammatory factors and organ function were observed in both groups.
  
  
  RESULTS
  The effective rate was higher in Xuebijing group than that of the control group (80.0% vs. 67.5%, P < 0.05). As compared with the control group, the LDH, alpha1-AG, alpha1-AT levels and the peak body temperature decreased markedly with the Xuebijing treatment going, and the secretion of TNF-alpha, IL-6, IL-8 was suppressed in Xuebijing group; but no significant difference was found in leptin level.
  
  
  CONCLUSIONS
  Xuebijing Injection may show a protective effect in patients with severe pneumonia. The mechanism is possibly with the decreased secretion of TNF-alpha, IL-6, and IL-8.
authors.affiliation: Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Qi
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Liang
authors.forename: Dan-Yang
authors.initials: DY
authors.lastname: She
authors.forename: Guang-Tao
authors.initials: GT
authors.lastname: Yan
authors.forename: Liang-An
authors.initials: LA
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016207:Cytokines / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy* / Q000276:immunology; D055815:Young Adult
chemical_list: D016207:Cytokines; D004365:Drugs, Chinese Herbal; C549376:Xuebijing