title: The rs2200733 variant on chromosome 4q25 is a risk factor for cardioembolic stroke related to atrial fibrillation in Polish patients.
abstract: OBJECTIVE
  A few single nucleotide polymorphisms (SNPs) on chromosome 4q25, associated with atrial fibrillation (AF), are risk factors for ischaemic stroke. We studied the significance of the SNP rs2200733 on chromosome 4q25 in different types of cardioembolic (CE) stroke.
  
  
  METHODS
  We genotyped 428 controls and 301 CE stroke patients, among whom 197 (65.4%) presented with high risk sources of embolism (CE stroke related to AF) and 104 with medium risk sources (CE stroke unrelated to AF). The SNP rs2200733 was analysed using real-time polymorphism chain reaction.
  
  
  RESULTS
  Both univariate and multivariate regression analyses showed that the studied variant affected risk of all CE strokes or CE strokes related to AF in recessive and additive mo-dels. The two types of CE stroke differed significantly in demographics and distribution of vascular risk factors.
  
  
  CONCLUSIONS
  The SNP rs2200733 on chromosome 4q25 is a risk factor for CE stroke related to AF only.
authors.affiliation: Uniwersytet Jagielloński, Collegium Medicum, Katedra i Klinika Neurologii, ul. Botaniczna 3, 31-503 Kraków. marcin.a.wnuk@gmail.com
authors.forename: Marcin
authors.initials: M
authors.lastname: Wnuk
authors.forename: Joanna
authors.initials: J
authors.lastname: Pera
authors.forename: Jeremiasz
authors.initials: J
authors.lastname: Jagiełła
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Szczygieł
authors.forename: Antoni
authors.initials: A
authors.lastname: Ferens
authors.forename: Karolina
authors.initials: K
authors.lastname: Spisak
authors.forename: Paweł
authors.initials: P
authors.lastname: Wołkow
authors.forename: Maria
authors.initials: M
authors.lastname: Kmieć
authors.forename: Jacek
authors.initials: J
authors.lastname: Burkot
authors.forename: Joanna
authors.initials: J
authors.lastname: Chrzanowska-Waśko
authors.forename: Wojciech
authors.initials: W
authors.lastname: Turaj
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Słowik
mesh_terms: D001281:Atrial Fibrillation / Q000150:complications / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis; D020521:Stroke / Q000150:complications / Q000235:genetics*; D044465:White People / Q000235:genetics*