title: Distribution of cyanide in heart blood, peripheral blood and gastric contents in 21 cyanide related fatalities.
abstract: This paper presents 21 cases related to cyanide intoxication by oral ingestion. Cyanide concentrations in biological specimens are especially different from the type of postmortem specimens, and very important in interpreting the cause of death in postmortem forensic toxicology. Besides the detection of cyanide in autopsy specimens, the autopsy findings were unremarkable. Biological samples (0.2mL or equal to less than 10μg of cyanide) were analyzed colorimetrically for cyanide. In a series of 21 cyanide fatalities, the concentration ranges (mean±SD) of cyanide in heart blood, peripheral blood and gastric contents were 0.1-248.6mg/L (38.1±56.6mg/L), 0.3-212.4mg/L (17.1±45.1mg/L) and 2.0-6398.0mg/kg (859.0±1486.2mg/kg), respectively. The ranges of the heart/peripheral blood concentration ratio and gastric contents/peripheral blood concentration ratio were 0.3-10.6 (mean 3.4) and 3.4-402.4 (mean 86.0), respectively. From the difference of cyanide concentration and the concentration ratio of cyanide in different types of postmortem specimens, the possibility of the postmortem redistribution of cyanide and death by oral ingestion of cyanide could be confirmed. We reported cyanide fatal cases along with a review of literature.
authors.affiliation: Drug & Toxicology Division, Forensic Science Department, National Forensic Service, 331-1 Shinwol 7-dong, Yangcheon-gu, Seoul 158-707, Republic of Korea. rheejs@nisi.go.kr
authors.forename: Jongsook
authors.initials: J
authors.lastname: Rhee
authors.forename: Jinmi
authors.initials: J
authors.lastname: Jung
authors.forename: Hyesun
authors.initials: H
authors.lastname: Yeom
authors.forename: Hansun
authors.initials: H
authors.lastname: Lee
authors.forename: Sangki
authors.initials: S
authors.lastname: Lee
authors.forename: Yoosin
authors.initials: Y
authors.lastname: Park
authors.forename: Heesun
authors.initials: H
authors.lastname: Chung
mesh_terms: D000059:Accidents; D000328:Adult; D000368:Aged; D002648:Child; D003124:Colorimetry; D003486:Cyanides / Q000032:analysis* / Q000506:poisoning*; D005260:Female; D053593:Forensic Toxicology; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D013405:Suicide
chemical_list: D003486:Cyanides