title: Hepatocellular carcinoma arising in a pigmented telangiectatic adenoma with nuclear β-catenin and glutamine synthetase positivity: case report and review of the literature.
abstract: Telangiectatic hepatocellular adenoma is a rare, recently recognized subtype of hepatocellular adenoma that is often underrecognized by pathologists. We report a case of hepatocellular carcinoma arising within a pigmented telangiectatic hepatocellular adenoma in a noncirrhotic man with diffuse glutamine synthetase and nuclear β-catenin positivity. This case highlights malignant transformation of telangiectatic adenomas, and describes a previously unreported association between pigment deposition and telangiectatic adenoma. Radiology, gross pathology, and histopathology are shown. Review of the literature with attention to β-catenin and glutamine synthetase staining, malignant transformation, patient characteristics, the presence of Dubin-Johnson-like pigment, and genetic characteristics of telangiectatic adenomas are discussed.
authors.affiliation: Department of Pathology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. jaclyn.hechtman@mountsinai.org
authors.forename: Jaclyn F
authors.initials: JF
authors.lastname: Hechtman
authors.forename: Mohammad
authors.initials: M
authors.lastname: Raoufi
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Fiel
authors.forename: Bachir
authors.initials: B
authors.lastname: Taouli
authors.forename: Marcelo
authors.initials: M
authors.lastname: Facciuto
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Schiano
authors.forename: Amanda G
authors.initials: AG
authors.lastname: Blouin
authors.forename: Swan N
authors.initials: SN
authors.lastname: Thung
mesh_terms: D018248:Adenoma, Liver Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D010858:Pigmentation; D013684:Telangiectasis / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D051176:beta Catenin; D005974:Glutamate-Ammonia Ligase