title: Encapsulation of astaxanthin-rich Xanthophyllomyces dendrorhous for antioxidant delivery.
abstract: Calcium alginate gel (CAG) beads were used to entrap the antioxidant astaxanthin-rich Xanthophyllomyces dendrorhous (ASX) by ionic gelation. ASX-CAG bead entrapment efficiency and release behavior, as influenced by alginate and CaCl(2) concentration and hardening time, were investigated. The optimized bead preparation conditions that gave rise to an efficient ASX release pattern were 1.5% alginate, 50mM CaCl(2), and a 5min hardening time. The antioxidant activity of non-encapsulated ASX was maintained for 4 days and then sharply decreased, whereas encapsulated ASX was maintained for 6 days. These results revealed that physical entrapment of ASX within CAG beads could be an effective technique for protecting the antioxidant activity of ASX from lipid peroxidation.
authors.affiliation: Department of Food and Nutrition, Hanyang University, Sungdong-gu, Seoul 133-791, Republic of Korea.
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Sun-Ah
authors.initials: SA
authors.lastname: Park
authors.forename: Donghwa
authors.initials: D
authors.lastname: Chung
authors.forename: Hyeon Gyu
authors.initials: HG
authors.lastname: Lee
mesh_terms: D000464:Alginates / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry* / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D005753:Gastric Mucosa / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007501:Iron / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008863:Microspheres; D055585:Physical Phenomena; D013858:Thiobarbiturates / Q000737:chemistry; D013861:Thiocyanates / Q000737:chemistry; D024341:Xanthophylls / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000464:Alginates; D000975:Antioxidants; D013858:Thiobarbiturates; D013861:Thiocyanates; D024341:Xanthophylls; C103724:ferric thiocyanate; C005948:astaxanthine; D007501:Iron; C029684:thiobarbituric acid