title: Differential expression of hsp90, gelsolin and gst-pi in human gastric-carcinoma cell-lines.
abstract: We have analyzed proteins produced in Various human gastric carcinoma cell lines and normal gastric mucosa. The production of HSP90 increased in eight gastric carcinoma cell lines. Gelsolin content was down-regulated in seven gastric carcinoma cell lines. Furthermore, the production of GST-pi increased in a poorly differentiated adenocarcinoma cell line and two scirrhous gastric carcinoma cell lines. These results suggest that increased production of HSP90 and down-regulation of gelsolin play an important role in gastric carcinogenesis, and that abundant production of GST-pi is related to unique behavior of some scirrhous gastric carcinomas.
authors.affiliation: HOKKAIDO UNIV,SCH MED,INST CANC,MOLEC GENET LAB,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN. HOKKAIDO UNIV,SCH DENT,DEPT ORAL SURG 1,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN. HIROSHIMA UNIV,NUCL MED & BIOL RES INST,DEPT PATHOL,MINAMI KU,HIROSHIMA 734,JAPAN.
authors.forename: S
authors.initials: S
authors.lastname: Moriya
authors.forename: K
authors.initials: K
authors.lastname: Yanagihara
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: N
authors.initials: N
authors.lastname: Kuzumaki