title: Estrogen and thrombosis: controversies and common sense.
abstract: Soon after the introduction of hormonal oral contraceptive agents reports of thrombotic complications appeared. In the past several decades, large epidemiological studies helped defined these risks for both arterial and venous complications. Clinicians can assess a patient's risk of thrombosis by both composition of the agent and patients' personal risk factors. For women with bleeding disorders these prothrombotic changes can help decrease bleeding complications. There is now also abundant data on future management of patients with estrogen related thrombosis.
authors.affiliation: Knight Cancer Center, Hematology/Laboratory Medicine, Departments of Medicine, Pathology, and Pediatrics, Oregon Health Sciences University, Portland, OR 97229-3098, USA. delought@ohsu.edu
authors.forename: Thomas G
authors.initials: TG
authors.lastname: DeLoughery
mesh_terms: D000328:Adult; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D004967:Estrogens / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D020141:Hemostatic Disorders / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D012307:Risk Factors; D013927:Thrombosis / Q000139:chemically induced* / Q000453:epidemiology; D020246:Venous Thrombosis / Q000139:chemically induced / Q000453:epidemiology
chemical_list: D003278:Contraceptives, Oral, Hormonal; D004967:Estrogens