title: Recent developments in the synthesis and biological activity of muramylpeptides.
abstract: Derivatives of muramyl dipeptide (MDP) are considered as immunostimulants and adjuvants in the immunotherapy of cancer and infections. The interest in these compounds is mainly related to a high variety of their structure and biological properties. Here, we describe the synthesis and biological activity of several recently developed classes of MDP analogues. We also report potential of these analogues in the treatment of cancer and infectious diseases in experimental systems and cancer patients.
authors.affiliation: Faculty of Chemistry, Department of Organic Chemistry, Gdansk University of Technology, 11/12 G. Narutowicza St, 80-233 Gdansk, Poland. kd@chem.pg.gda.pl
authors.forename: K
authors.initials: K
authors.lastname: Dzierzbicka
authors.forename: A
authors.initials: A
authors.lastname: Wardowska
authors.forename: P
authors.initials: P
authors.lastname: Trzonkowski
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D003141:Communicable Diseases / Q000188:drug therapy*; D006801:Humans; D008968:Molecular Conformation; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000119:Acetylmuramyl-Alanyl-Isoglutamine