title: [Expression of Piwil2 and its relationship with tumor invasion and metastasis in papillary thyroid carcinoma].
abstract: OBJECTIVE
  To study the expressions of Piwil2 protein and mRNA in papillary thyroid carcinoma (PTC) and the relationship between Piwil2 and the invasion and metastasis of PTC.
  
  
  METHODS
  Immunohistochemistry and in situ hybridization were used to detect the expression of Piwil2 protein and mRNA in 60 cases of PTC with the matched adjacent non-cancerous epithelium (NCE).
  
  
  RESULTS
  The positive rates of Piwil2 protein expression in PTC and NCE were 88.3% (53/60) and 10.0% (6/60) respectively, with significant difference (χ² = 73.654, P < 0.01). The positive rates of Piwil2 mRNA expression in PTC and NCE were 85.0% (51/60) and 6.7% (4/60) respectively, also with significant difference (χ(2) = 74.148, P < 0.01). Up-regulated expressions of Piwil2 protein and mRNA were related to the invasion and metastasis of PTC (P < 0.05).
  
  
  CONCLUSIONS
  Piwil2 may play a role in the invasion and metastasis of PTC.
authors.affiliation: Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Key-Disciplines Laboratory Clinical Medicine, Zhengzhou 450052, China. detaoyin@zzu.edu.cn
authors.forename: De-tao
authors.initials: DT
authors.lastname: Yin
authors.forename: Hong-qiang
authors.initials: HQ
authors.lastname: Li
authors.forename: Yong-fei
authors.initials: YF
authors.lastname: Wang
authors.forename: Sheng-li
authors.initials: SL
authors.lastname: Cao
authors.forename: Yu-bing
authors.initials: YB
authors.lastname: Zhou
authors.forename: Li-yun
authors.initials: LY
authors.lastname: Zheng
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Jiang
authors.forename: Qing-duan
authors.initials: QD
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D060565:Argonaute Proteins; D002277:Carcinoma; D002291:Carcinoma, Papillary; D002648:Child; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
chemical_list: D060565:Argonaute Proteins; C486868:PIWIL2 protein, human; D011506:Proteins; D012333:RNA, Messenger