title: Activation and effector functions of human RORC+ innate lymphoid cells.
abstract: Innate lymphoid cells expressing the nuclear hormone receptor RORC have emerged as important players in human mucosal immunity. These cells combine innate modes of activation such as Toll-like receptor signaling with secretion of adaptive effector molecules including IL-2, BAFF and the Th17 cytokines IL-17 and IL-22. This endows these cells with the ability to rapidly respond to changes in cytokine milieu as well as changes in microbial composition and to affect both intestinal homeostasis and activation of adaptive immune cells.
authors.affiliation: Department of Hematology, Erasmus University Medical Center, PO Box 2040, 3000CA Rotterdam, The Netherlands.
authors.forename: Ferry
authors.initials: F
authors.lastname: Cornelissen
authors.forename: Patricia
authors.initials: P
authors.lastname: Aparicio Domingo
authors.forename: Rogier M
authors.initials: RM
authors.lastname: Reijmers
authors.forename: Tom
authors.initials: T
authors.lastname: Cupedo
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539900:RORC protein, human; D051193:Toll-Like Receptors