title: Catheter delivery systems for infusions into the cortex.
abstract: In the context of intraparenchymal delivery of therapeutic agents into brain parenchyma for the purpose of treating serious brain diseases, we present the scientific and medical need for infusion from a single source to cover a large area of the cerebral cortex, which we refer to as 'surface-contoured distributions' (SCD). The designs of two devices suitable for obtaining such SCD's are described, and the results of preliminary experimental studies with prototypes of them are reported. The studies were done in ex vivo samples of mammalian brain tissues, and histological sections of the brains confirmed that we had covered the large surface area desired. Work to test that the infusate penetrates the thickness of the cortex remains for the future.
authors.affiliation: Therataxis LLC, JHU Eastern Complex, 1101 E. 33rd Street, Suite B305, Baltimore, MD 21218, USA.
authors.forename: D
authors.initials: D
authors.lastname: Poston
authors.forename: R
authors.initials: R
authors.lastname: Raghavan
authors.forename: G T
authors.initials: GT
authors.lastname: Gillies
mesh_terms: D000818:Animals; D057785:Catheters; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D012756:Sheep