title: [Rheumatoid arthritis: a typical multifactorial genetic disease: review of the literature].
abstract: Environmental factors can be triggers for the clinical appearance of rheumatoid arthritis in subjects with genetic susceptibility. Genetic factors account for 60% of disease susceptibility. This review is focused on the genetic and environmental basis of the susceptibility to arthritis.
authors.affiliation: UOC Medicina 5, Roma. filippo.iebba@virgilio.it
authors.forename: Filippo
authors.initials: F
authors.lastname: Iebba
authors.forename: Fiorella
authors.initials: F
authors.lastname: Di Sora
authors.forename: Agapito
authors.initials: A
authors.lastname: Tarasi
authors.forename: Wilma
authors.initials: W
authors.lastname: Leti
authors.forename: Francesco
authors.initials: F
authors.lastname: Montella
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D015415:Biomarkers / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects; D019317:Evidence-Based Medicine; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics; D007558:Italy / Q000453:epidemiology; D011247:Pregnancy; D015995:Prevalence; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects; D047990:TNF Receptor-Associated Factor 1 / Q000235:genetics
chemical_list: D015415:Biomarkers; D006684:HLA-DR Antigens; C431713:IRF5 protein, human; D050835:Interferon Regulatory Factors; D047990:TNF Receptor-Associated Factor 1; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22