title: Preoperative radiotherapy for muscle-invading bladder-carcinoma.
abstract: One hundred five patients with clinical stage T2-T4 transitional cell bladder carcinoma who completed either low-dose (20-26 Gy) or high dose (40-50 Gy) preoperative radiotherapy (RT) followed by cystectomy were reviewed. Five-year actuarial survival was 42%, 52%, and 17% for stages T2, T3, and T4, respectively. Five-year local control rates for stages T2, T3, and T4 was 93%, 93% and 22%, respectively. Survival, local control, distant metastasis and complications were similar for both preoperative regimens. The high rates of local control support the use of preoperative RT in selected patients with bladder carcinoma.
authors.affiliation: BOWMAN GRAY SCH MED,DEPT RADIOL,MED CTR BLVD,WINSTON SALEM,NC 27157. BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI,WINSTON SALEM,NC 27157. DUKE UNIV,MED CTR,DIV RADIAT ONCOL,DURHAM,NC 27710.
authors.forename: J
authors.initials: J
authors.lastname: Cox
authors.forename: K
authors.initials: K
authors.lastname: Greven
authors.forename: M
authors.initials: M
authors.lastname: Anscher
authors.forename: T
authors.initials: T
authors.lastname: Morgan