title: Pharmacokinetics of intravenous levofloxacin administered at 750 milligrams in obese adults.
abstract: The physiochemical properties of levofloxacin suggest that it is an agent which may exhibit altered pharmacokinetics in obese individuals. The purpose of this study was to describe the pharmacokinetics of a single 750-mg intravenous dose of levofloxacin in both hospitalized and ambulatory obese individuals. The hypothesis was that a standard dose of levofloxacin in obese individuals would achieve serum concentrations likely to be therapeutic. A single levofloxacin dose of 750 mg was infused over 90 min, and seven serial serum samples were subsequently obtained to evaluate the pharmacokinetics after the first dose. The peak concentrations of levofloxacin were comparable to those seen with normal-weight individuals. However, the area under the concentration-time curve and clearance were quite variable. Accelerated clearance was evident in the ambulatory obese individuals. Further investigation of the effects of obesity on the pharmacokinetics of levofloxacin is necessary to ensure optimal dosing.
authors.affiliation: UK Healthcare, University of Kentucky College of Pharmacy, 800 Rose St H-110, Lexington, Kentucky 40536-0293, USA. amcook0@uky.edu
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Cook
authors.forename: Craig
authors.initials: C
authors.lastname: Martin
authors.forename: Val R
authors.initials: VR
authors.lastname: Adams
authors.forename: R Scott
authors.initials: RS
authors.lastname: Morehead
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D015242:Ofloxacin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin