title: [Correlation between neutrophil cytosolic factor 1 gene C923T polymorphism and cerebral hemorrhage in the Han in Changsha].
abstract: OBJECTIVE
  To investigate the relation between C923T(Ala308Val)polymorphism in exon 10 of neutrophil cytosolic factor 1 (NCF1) gene and cerebral hemorrhage in the Han in Changsha and to evaluate the effect of C923T(Ala308Val) polymorphism on plasma lipid levels.
  
  
  METHODS
  Changsha Han C923T(Ala308Val)polymorphism in NCF1 gene was determined by PCR single strand conformation polymorphism analysis and DNA sequencing in 100 healthy controls, 110 patients with cerebral hemorrhage, and 10 cerebral hemorrhage pedigrees. The level of plasma lipid was measured by routine methods.
  
  
  RESULTS
  No significant difference was found in frequencies of genotypes and alleles of C923T(Ala308Val)polymorphism among the controls, cerebral hemorrhage patients and cerebral hemorrhage pedigrees. The serum level of TG in the CT genotype of cerebral hemorrhage patients and controls tended toward higher than that in CC genotype, but the trend did not reach significance (P>0.05).
  
  
  CONCLUSIONS
  There seems no correlation between C923T(Ala308Val)polymorphism and cerebral hemorrhage in Hans people in Hunan province.
authors.affiliation: Department of Neurology, Hunan Brain Hospital, Changsha 410007, China.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Huang
authors.forename: Qidong
authors.initials: Q
authors.lastname: Yang
mesh_terms: D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D002543:Cerebral Hemorrhage / Q000235:genetics*; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D019255:NADPH Oxidases / Q000235:genetics*; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D019255:NADPH Oxidases; C060505:neutrophil cytosolic factor 1