title: Preliminary study on glucose control with an artificial pancreas in postoperative sepsis patients.
abstract: BACKGROUND
  Glucose control is essential to avoid hypoglycemia in postoperative patients.
  
  
  OBJECTIVE
  To conduct a preliminary examination to evaluate the feasibility of the use of an artificial pancreas for glucose control as well as the accuracy of assessment by the artificial pancreas of the insulin dose required.
  
  
  METHODS
  Glucose control using an artificial pancreas was undertaken in 8 postoperative sepsis patients. The blood glucose level was set at 80-150 mg/dl. Blood glucose levels over time, insulin dose requirements, and occurrence of hypoglycemia (≤40 mg/dl) were recorded for each patient. The patients were divided into 2 groups based on the total insulin dose they received over the 7 days (HG, n = 4: consisting of patients who required a higher insulin dose; LG, n = 4: patients who required a lower insulin dose). The data of the 2 groups were analyzed retrospectively.
  
  
  RESULTS
  The blood glucose level before glucose control was 203.3 ± 9.9 mg/dl and could be controlled in all patients to within the target range. No hypoglycemia events were recorded for any of the patients. The insulin dose in the HG and LG groups was 21,824.8 ± 6,030.4 and 6,254.5 ± 3,402.3 mU/kg (p < 0.05).
  
  
  CONCLUSIONS
  Accurate glucose control could be achieved with the artificial pancreas.
authors.affiliation: Department of Critical Care Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: N
authors.initials: N
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Shozushima
authors.forename: K
authors.initials: K
authors.lastname: Hoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Akitomi
authors.forename: T
authors.initials: T
authors.lastname: Kikkawa
authors.forename: C
authors.initials: C
authors.lastname: Onodera
authors.forename: M
authors.initials: M
authors.lastname: Kojika
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: G
authors.initials: G
authors.lastname: Wakabayashi
authors.forename: S
authors.initials: S
authors.lastname: Endo
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control*; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D019397:Pancreas, Artificial; D011183:Postoperative Complications / Q000517:prevention & control*; D011184:Postoperative Period; D012189:Retrospective Studies; D018805:Sepsis / Q000097:blood* / Q000601:surgery*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose