title: The treatment of colorectal hepatic metastases by continuous local infusion of interleukin-2.
abstract: Patients with hepatic metastases from colorectal cancer appear to be resistant to most forms of therapy. Recent reports suggest synergism between systemically administered recombinant interleukin-2 (rIL-2) and 5-fluorouracil (5-FU) with responses documented in the treatment of advanced colonic tumours albeit with significant toxicity. Local continuous infusion of rIL-2 into selected sites may reduce toxicity and increase efficacy. We have assessed the feasibility of continuously infusing rIL-2 into the region of a hepatic metastasis in 3 patients via a catheter placed within the liver under ultrasound guidance in a regimen including systemic rIL-2 and 5FU.
authors.affiliation: PETERBOROUGH DIST GEN HOSP,DEPT SURG,PETERBOROUGH PE3 6DA,ENGLAND. UNIV LEICESTER,LEICESTER ROYAL INFIRM,SCH MED,DEPT SURG,LEICESTER LE1 7RH,ENGLAND.
authors.forename: J
authors.initials: J
authors.lastname: Hollingworth
authors.forename: E
authors.initials: E
authors.lastname: Watkin
authors.forename: S
authors.initials: S
authors.lastname: Ubhi
authors.forename: T
authors.initials: T
authors.lastname: Horsburgh
authors.forename: P
authors.initials: P
authors.lastname: Veitch
authors.forename: P
authors.initials: P
authors.lastname: Bell