title: Recovery of sensitivity to cisplatinum and epidoxorubicin by ionidamine and interferon in advanced ovarian-cancer.
abstract: Eighteen patients with advanced ovarian cancer not or no longer responding to cisplatinum and epidoxorubicin including combination chemotherapy were retreated with the above two drugs in combination with lonidamine and interferon, administered with the aim of restoring chemosensitivity. Overall response rate was 32%, with one durable complete response and four partial responses. Toxicity was quite manageable, myalgia being the main additional toxic effect with respect to those reported with conventional chemotherapy. Our study emphasizes the need for additional trials with agents able to overcome drug resistance, which is the chief determinant of treatment failure in advanced ovarian cancer.
authors.affiliation: UNIV CAGLIARI,IST MED INTERNA,I-09100 CAGLIARI,ITALY. IST TUMORI NAPOLI,DIV ENDOCRINOL ONCOL,I-80131 NAPLES,ITALY. IST MED LEGALE AM,I-20129 MILAN,ITALY. UNIV CATANZARO,CATTEDRA GINECOL & OSTETRICIA,CATANZARO,ITALY. OSPED LORETO MARE,I-80100 NAPLES,ITALY. UNIV NAPLES,CHIRURG GEN & TRAPIANTI ORGANO,I-80131 NAPLES,ITALY.
authors.forename: R
authors.initials: R
authors.lastname: Iaffaioli
authors.forename: A
authors.initials: A
authors.lastname: Tortoriello
authors.forename: G
authors.initials: G
authors.lastname: Facchini
authors.forename: F
authors.initials: F
authors.lastname: Caponigro
authors.forename: P
authors.initials: P
authors.lastname: Mastrantonio
authors.forename: M
authors.initials: M
authors.lastname: Barzelloni
authors.forename: G
authors.initials: G
authors.lastname: Gesue
authors.forename: G
authors.initials: G
authors.lastname: Mantovani
authors.forename: M
authors.initials: M
authors.lastname: Santangelo