title: How do glucocorticoids cause hypertension: role of nitric oxide deficiency, oxidative stress, and eicosanoids.
abstract: The exact mechanism by which glucocorticoid induces hypertension is unclear. Several mechanisms have been proposed, although there is evidence against the role of sodium and water retention as well as sympathetic nerve activation. This review highlights the role of nitric oxide-redox imbalance and their interactions with arachidonic acid metabolism in glucocorticoid-induced hypertension in humans and experimental animal models.
authors.affiliation: Department of Nephrology, St George Hospital, 50 Montgomery Street, Kogarah, Sydney, NSW 2217, Australia.
authors.forename: Sharon L H
authors.initials: SL
authors.lastname: Ong
authors.forename: Judith A
authors.initials: JA
authors.lastname: Whitworth
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003480:Cushing Syndrome / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D015777:Eicosanoids / Q000097:blood* / Q000378:metabolism; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D007049:Iatrogenic Disease; D009569:Nitric Oxide / Q000097:blood* / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000037:antagonists & inhibitors / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015777:Eicosanoids; D005938:Glucocorticoids; D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III