title: [Voxel-based morphometry on grey matter concentration of the brain in first-episode, antipsychotic-naive major depressive disorder].
abstract: OBJECTIVE
  To examine the structural differences in regional gray matter density between a sample of major depressive disorder (MDD) and healthy controls, using the magnetic resonance imaging (MRI) to find the base of pathophysiologic mechanism in depression development.
  
  
  METHODS
  A total of 38 MDD patients and 42 healthy subjects enrolled in the MRI scans. Voxel-based morphometry was used to test the difference in gray matter between the 2 groups.
  
  
  RESULTS
  The MDD group showed significantly lower gray density than the healthy control group in the right middle frontal gyrus, right superior frontal gyrus, left inferior frontal gyrus and left superior frontal gyrus. However, the healthy control group showed significantly lower gray density than the MDD group in the right precuneus, left anterior central gyrus and right anterior cingutate.
  
  
  CONCLUSIONS
  Structural brain abnormalities in MDD patients may be the pathological bases for MDD development.
authors.affiliation: Medical Psychological Research Center, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Jianghua
authors.initials: J
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Xiao
authors.forename: Xueling
authors.initials: X
authors.lastname: Zhu
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Shuqiao
authors.initials: S
authors.lastname: Yao
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D055815:Young Adult