title: [Genetic polymorphisms as predictors of response to antiviral treatment in chronic hepatitis C virus infection].
abstract: The review discusses the genetic polymorphisms involved in the pathogenesis of hepatitis C virus (HCV) infection, that may determine the outcome of disease. In this field earlier both certain major histocompatibility complex (MHC) alleles and some cytokine gene variants have also been studied. Recently, the genome-wide association study (GWAS) and targeted single nucleotide polymorphism (SNP) analysis have revealed that a variant in the promoter region of interleukin-28B (IL-28B) gene is strongly linked to viral clearance and it may be the strongest pretreatment predictor of treatment response in chronic hepatitis C. Last year it was shown that two genetic variants leading to inosine triphosphatase deficiency protect against haemolytic anemia in patients receiving ribavirin during antiviral treatment for chronic HCV infection.
authors.affiliation: Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ I. Belgyógyászati Klinika Pécs Ifjúság u. 13. 7624. alajos.par@aok.pte.hu
authors.forename: Alajos
authors.initials: A
authors.lastname: Pár
mesh_terms: D000483:Alleles; D000998:Antiviral Agents / Q000627:therapeutic use*; D016207:Cytokines / Q000235:genetics*; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007372:Interferons; D016753:Interleukin-10 / Q000235:genetics; D007378:Interleukins / Q000235:genetics; D008233:Lymphotoxin-alpha / Q000235:genetics; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011755:Pyrophosphatases / Q000235:genetics; D019562:Viral Load / Q000187:drug effects; D000097630:Inosine Triphosphatase; D000095022:Interferon Lambda
chemical_list: D000998:Antiviral Agents; D016207:Cytokines; D007372:Interferons; D016753:Interleukin-10; D007378:Interleukins; D008233:Lymphotoxin-alpha; D011755:Pyrophosphatases; D000097630:Inosine Triphosphatase; C000624353:interferon-lambda, human; D000095022:Interferon Lambda