title: A case of prostatic adenocarcinoma with Paneth cell-like appearance.
abstract: Paneth cell-like appearance of prostatic carcinoma cells with eosinophilic cytoplasmic granules is rarely reported, and is known to be associated with neuroendocrine differentiation of carcinoma cells. We report a case of prostatic adenocarcinoma with Paneth cell-like appearance that was localized next to conventional adenocarcinoma, and demonstrate its neuroendocrine differentiation by using immunohistochemical analysis. Paneth cell-like appearance of prostatic carcinoma cells should be recognized and considered as a sign of neuroendocrine differentiation due to the possible association with resistance to hormone therapy.
authors.affiliation: Department of Pathology, Tohoku University School of Medicine, Sendai, Japan. yasu-naka@patholo2.med.tohoku.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Fujishima
authors.forename: Mika
authors.initials: M
authors.lastname: Watanabe
authors.forename: Shinji
authors.initials: S
authors.lastname: Taniuchi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ishida
authors.forename: Shigeto
authors.initials: S
authors.lastname: Ishidoya
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Arai
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000378:metabolism; D053379:Chromogranin A / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019879:Paneth Cells / Q000378:metabolism / Q000473:pathology*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D012701:Serotonin / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D053379:Chromogranin A; D016708:Synaptophysin; D012701:Serotonin