title: Discovery of new photoactivatable diaryltetrazoles for photoclick chemistry via 'scaffold hopping'.
abstract: We report the discovery of two long-wavelength (365 nm) photoactivatable diaryltetrazoles through screening a small library of diaryltetrazoles that were designed using a 'scaffold hopping' strategy. A naphthalene-derived tetrazole showed excellent reactivity in the photoinduced cycloaddition reaction with methyl methacrylate under 365 nm photoirradiation in acetonitrile PBS buffer mixture. Besides, the brightly fluorescent pyrazoline cycloadducts that were formed further increase the potential utility of these new diaryltetrazoles as 'photoclick' reagents and as reporters in biological studies.
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Yu
authors.forename: Lok Yin
authors.initials: LY
authors.lastname: Ho
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
mesh_terms: D003500:Cyclization; D005456:Fluorescent Dyes / Q000737:chemistry; D009281:Naphthalenes / Q000737:chemistry; D010777:Photochemistry; D013777:Tetrazoles / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D005456:Fluorescent Dyes; D009281:Naphthalenes; D013777:Tetrazoles; C031721:naphthalene