title: Seed and grow: a two-step model for nuclear body biogenesis.
abstract: Nuclear bodies are dynamic structures that form at sites of specific activities associated with gene expression and genome maintenance. A paper in this issue (White et al. 2011. J. Cell Biol. doi: 10.1083/jcb.201012077) highlights key features of nuclear body biogenesis and suggests a unifying model in which formation of nuclear bodies is driven by nonrandom, biologically determined initial seeding events followed by stochastic self-assembly.
authors.affiliation: Department of Cell Biology, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA. mirek.dundr@rosalindfranklin.edu
authors.forename: Miroslav
authors.initials: M
authors.lastname: Dundr
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D022003:Cell Nucleus Structures / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics / Q000378:metabolism*; D051858:Forkhead Transcription Factors / Q000378:metabolism; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D008938:Mitosis; D008954:Models, Biological; D010445:Peptide Elongation Factors / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D063146:Polycomb-Group Proteins; D012322:RNA Precursors / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D020885:Ribonucleoprotein, U7 Small Nuclear / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D029721:Drosophila Proteins; D051858:Forkhead Transcription Factors; D006657:Histones; D010445:Peptide Elongation Factors; D010750:Phosphoproteins; D063146:Polycomb-Group Proteins; D012322:RNA Precursors; D012333:RNA, Messenger; D012097:Repressor Proteins; D020885:Ribonucleoprotein, U7 Small Nuclear; C470423:Spt6 protein, Drosophila