title: Reduced E-cadherin expression is associated with lymph node metastases in laryngeal squamous cell carcinoma.
abstract: OBJECTIVE
  To investigate the expression of E-cadherin and its relationship with clinicopathological parameters in laryngeal squamous cell carcinoma (LSCC).
  
  
  METHODS
  Sixty-four patients who had previously undergone complete resection of tumor for LSCC were studied retrospectively. The level of E-cadherin expression in tumor tissues and paired nontumor tissues were determined by immunohistochemistry.
  
  
  RESULTS
  The expression of E-cadherin in tumor tissues was significantly lower than nontumor tissues (P<0.001). Reduced E-cadherin expression was significantly correlated with lymph node metastases (P<0.001). Kaplan-Meier survival estimates showed a significant correlation between E-cadherin expression and patient survival rate (log-rank P<0.05). Multivariate Cox proportional hazards model analysis confirmed that lymph node metastases (P=0.001) and tumor stage (P=0.013) were statistically significant, independent predictor of prognosis.
  
  
  CONCLUSIONS
  Expression of E-cadherin is an independent predictor of lymph node metastases in LSCC. However, it does not appear to be a better prognostic predictor than other established markers in LSCC.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, PR China.
authors.forename: Jing-jia
authors.initials: JJ
authors.lastname: Li
authors.forename: Ge-hua
authors.initials: GH
authors.lastname: Zhang
authors.forename: Xin-ming
authors.initials: XM
authors.lastname: Yang
authors.forename: Shi-sheng
authors.initials: SS
authors.lastname: Li
authors.forename: Xian
authors.initials: X
authors.lastname: Liu
authors.forename: Qin-tai
authors.initials: QT
authors.lastname: Yang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Ye
mesh_terms: D000368:Aged; D015820:Cadherins / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy; D007830:Larynx / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D012016:Reference Values; D012189:Retrospective Studies
chemical_list: D015820:Cadherins