title: Different models of genetic variation and their effect on genomic evaluation.
abstract: BACKGROUND
  The theory of genomic selection is based on the prediction of the effects of quantitative trait loci (QTL) in linkage disequilibrium (LD) with markers. However, there is increasing evidence that genomic selection also relies on "relationships" between individuals to accurately predict genetic values. Therefore, a better understanding of what genomic selection actually predicts is relevant so that appropriate methods of analysis are used in genomic evaluations.
  
  
  METHODS
  Simulation was used to compare the performance of estimates of breeding values based on pedigree relationships (Best Linear Unbiased Prediction, BLUP), genomic relationships (gBLUP), and based on a Bayesian variable selection model (Bayes B) to estimate breeding values under a range of different underlying models of genetic variation. The effects of different marker densities and varying animal relationships were also examined.
  
  
  RESULTS
  This study shows that genomic selection methods can predict a proportion of the additive genetic value when genetic variation is controlled by common quantitative trait loci (QTL model), rare loci (rare variant model), all loci (infinitesimal model) and a random association (a polygenic model). The Bayes B method was able to estimate breeding values more accurately than gBLUP under the QTL and rare variant models, for the alternative marker densities and reference populations. The Bayes B and gBLUP methods had similar accuracies under the infinitesimal model.
  
  
  CONCLUSIONS
  Our results suggest that Bayes B is superior to gBLUP to estimate breeding values from genomic data. The underlying model of genetic variation greatly affects the predictive ability of genomic selection methods, and the superiority of Bayes B over gBLUP is highly dependent on the presence of large QTL effects. The use of SNP sequence data will outperform the less dense marker panels. However, the size and distribution of QTL effects and the size of reference populations still greatly influence the effectiveness of using sequence data for genomic prediction.
authors.affiliation: School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia. sclark9@une.edu.au
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Clark
authors.forename: John M
authors.initials: JM
authors.lastname: Hickey
authors.forename: Julius H J
authors.initials: JH
authors.lastname: van der Werf
mesh_terms: D000818:Animals; D001499:Bayes Theorem; D001947:Breeding / Q000706:statistics & numerical data*; D014644:Genetic Variation; D016678:Genome; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci / Q000235:genetics*; D012641:Selection, Genetic