title: PET in the diagnosis and management of patients with brain metastasis: current role and future perspectives.
abstract: Systemic cancer is the second most common cause of death in developed countries and metastatic brain tumour the most common tumour of the central nervous system (CNS). As the incidence of brain metastases appears to be rising, more accurate non-invasive imaging modalities for diagnosis, prognosis, prediction and follow-up of treatment are requisites for efficient patient management. Positron emission tomography (PET) imaging has the ability to evaluate different aspects of tumour microenvironment on the molecular and cellular level and impact the workup of patients with brain metastasis. This article reviews the current application of PET imaging in patients with metastatic brain disease.
authors.affiliation: Laboratory for Gene Therapy and Molecular Imaging at the Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Faculty of Medicine of the University of Cologne, Cologne, Germany.
authors.forename: Yannic
authors.initials: Y
authors.lastname: Waerzeggers
authors.forename: Kambiz
authors.initials: K
authors.lastname: Rahbar
authors.forename: Burkhard
authors.initials: B
authors.lastname: Riemann
authors.forename: Matthias
authors.initials: M
authors.lastname: Weckesser
authors.forename: Michael
authors.initials: M
authors.lastname: Schäfers
authors.forename: Volker
authors.initials: V
authors.lastname: Hesselmann
authors.forename: Thomas
authors.initials: T
authors.lastname: Niederstadt
authors.forename: Normann
authors.initials: N
authors.lastname: Willich
authors.forename: Walter
authors.initials: W
authors.lastname: Stummer
authors.forename: Werner
authors.initials: W
authors.lastname: Paulus
authors.forename: Otmar
authors.initials: O
authors.lastname: Schober
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Jacobs
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D017209:Apoptosis; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary* / Q000628:therapy; D049109:Cell Proliferation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D009336:Necrosis / Q000000981:diagnostic imaging; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000639:trends; D011956:Receptors, Cell Surface / Q000378:metabolism; D012008:Recurrence
chemical_list: D000596:Amino Acids; D011956:Receptors, Cell Surface; D005947:Glucose