title: Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates.
abstract: In vivo transcranial and noninvasive cavitation detection with blood-brain barrier (BBB) opening in nonhuman primates is hereby reported. The BBB in monkeys was opened transcranically using focused ultrasound (FUS) in conjunction with microbubbles. A passive cavitation detector, confocal with the FUS transducer, was used to identify and monitor the bubble behavior. During sonication, the cavitation spectrum, which was found to be region-, pressure-, and bubble-dependent, provided real-time feedback regarding the opening occurrence and its properties. These findings demonstrate feasibility of transcranial, cavitation-guided BBB opening using FUS and microbubbles in noninvasive human applications.
authors.forename: Yao-Sheng
authors.initials: YS
authors.lastname: Tung
authors.forename: Fabrice
authors.initials: F
authors.lastname: Marquet
authors.forename: Tobias
authors.initials: T
authors.lastname: Teichert
authors.forename: Vincent
authors.initials: V
authors.lastname: Ferrera
authors.forename: Elisa E
authors.initials: EE
authors.lastname: Konofagou