title: [Analysis of the therapeutic efficacy for 60 cases of T4 squamous cell carcinoma of the pyriform sinus].
abstract: OBJECTIVE
  To evaluate the treatment results of T4 squamous cell carcinoma of the pyriform sinus.
  
  
  METHODS
  Sixty patients with T4 cancer of the pyriform sinus were included in this retrospective analysis. Fifteen patients were treated with radiotherapy alone (Ra group) with 67.9 Gy. Seven patients were treated with surgery alone (S group) with no laryngeal function sparing surgery. Sixteen patients were treated with preoperative radiotherapy with 49.8 Gy followed by surgery including three cases with laryngeal function sparing surgery (R + S group). Twenty-two patients were treated with surgery followed by postoperative radiotherapy with 58.5 Gy (S + R group), and there was no laryngeal function sparing surgery in this group. The survival rate was calculated using Kaplan-Meier method.
  
  
  RESULTS
  The overall 5-year survival rate for all patients was 32.4%, 8.7% for R group, 33.3% for S group, 29.2% for R+S group, 47.7% for S+R group, 41.7% for combined therapy group (R + S group and S+R group) and 13.6% for single therapy group (S group and R group). There was a statistically significant difference between the two groups (P = 0.02). The overall 5-year survival rates for R + S group and S + R group were 29.2% and 47.7%, respectively, with no significant difference (P = 0.228). Surgery complications for R + S group was 50.0% and 31.8% for S + R group, with no significant difference (P = 0.258).
  
  
  CONCLUSIONS
  Combined therapy is the standard treatment modality for T4 squamous cell carcinoma of the pyriform sinus. Surgery with postoperative radiotherapy seems to be more advantageous.
authors.affiliation: Department of Head and Neck Surgery, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.forename: Zhen-gang
authors.initials: ZG
authors.lastname: Xu
authors.forename: Jing-wei
authors.initials: JW
authors.lastname: Luo
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D056144:Pyriform Sinus; D012189:Retrospective Studies; D015996:Survival Rate