title: Synthesis, characterization, and DNA-binding and -photocleavage properties of water-soluble lanthanide porphyrinate complexes.
abstract: A series of cationic lanthanide porphyrinate complexes of the general formula [(Por)Ln(H(2)O)(3)](+) (Ln(3+)=Yb(3+) and Er(3+)) were synthesized in moderate yields through the interaction of meso-pyridyl-substituted porphyrin free bases (H(2)Por) with [Ln{N(SiMe(3))(2)}(3)]·x[LiCl(thf)(3)], and the corresponding neutral derivatives [(Por)Ln(L(OMe))] (L(OMe)(-)=[(η(5)-C(5)H(5))Co{P(=O)(OMe)(2)}(3)](-)) were also prepared from [(Por)Ln(H(2)O)(3)](+) by the addition of the tripodal anion, L(OMe)(-), an effective encapsulating agent for lanthanide ions. Furthermore, the water-soluble lanthanide(III) porphyrinate complexes--including [(cis-DMPyDPP)Yb(H(2)O)(3)]Cl(3) (cis-DMPyDPP=5,10-bis(N-methylpyridinium-4'-y1)-15,20-di(phenyl)porphyrin), [(trans-DMPyDPP)Yb(H(2)O)(3)]Cl(3) (trans-DMPyDPP=5,15-bis(N-methylpyridinium-4'-y1)-10,20-di(phenyl)porphyrin), [(TMPyP)Yb(L(OMe))]I(4), and [(TMPyP)Er(L(OMe))]I(4) (TMPyP=tetrakis(N-methylpyridinium-4-y1)porphyrin)--were obtained by methylation of the corresponding complexes with methyl iodide and unambiguously characterized. The binding interactions and photocleavage activities of the water-soluble lanthanide(III) porphyrinate complexes towards DNA were investigated by UV-visible, fluorescence, and near-infrared luminescence spectroscopy, as well as circular dichroism and gel electrophoresis.
authors.affiliation: Department of Chemistry and Centre for Advanced Luminescence Materials, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P.R. China.
authors.forename: Xun-Jin
authors.initials: XJ
authors.lastname: Zhu
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Heidi Wing Chi
authors.initials: HW
authors.lastname: Leung
authors.forename: Wai-Kwok
authors.initials: WK
authors.lastname: Wong
authors.forename: Wai-Yeung
authors.initials: WY
authors.lastname: Wong
authors.forename: Daniel W J
authors.initials: DW
authors.lastname: Kwong
mesh_terms: D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D007477:Ions / Q000737:chemistry*; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D049449:Luminescence; D015394:Molecular Structure; D010087:Oxides / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D007477:Ions; D028581:Lanthanoid Series Elements; D010087:Oxides; D011166:Porphyrins; D014867:Water; D004247:DNA