title: [Late endothelial function in children with coronary aneurysm due to Kawasaki disease].
abstract: OBJECTIVE
  To evaluate the late endothelial function in children with coronary aneurysm due to Kawasaki disease (KD).
  
  
  METHODS
  Thirty-one children with coronary aneurysms due to KD who had the disease course for more than 1 year and twenty-one age-matched healthy children were enrolled. Brachial artery endothelium-dependent and -independent flow-mediated dilation (FMD), carotid arterial stiffness index (SI) and intima-media thickness (IMT) were measured by high-frequency ultrasound.
  
  
  RESULTS
  There were 9 cases of medium and 22 cases of giant coronary aneurysms in the KD group. Twelve KD patients had evidence of myocardial ischemia. Compared to the normal controls, the endothelium-dependent FMD decreased (P<0.05), the carotid arterial SI increased (P<0.05), and the carotid arterial intima-media thickness increased significantly (P<0.05) in children with coronary aneurysms due to KD. The endothelium-dependent FMD decreased more significantly in 12 KD patients with myocardial ischemia than in those without any evidence of myocardial ischemia (P<0.05).
  
  
  CONCLUSIONS
  Late endothelial dysfunction exists in children with coronary aneurysms due to KD, especially in those with myocardial ischemia.
authors.affiliation: Department of Cardiology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Duan
authors.forename: Zhong-Dong
authors.initials: ZD
authors.lastname: DU
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Li-Qun
authors.initials: LQ
authors.lastname: Jia
mesh_terms: D000293:Adolescent; D002648:Child; D003323:Coronary Aneurysm / Q000209:etiology / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000503:physiopathology; D014664:Vasodilation