title: Clinical course of patients with ophthalmoplegia caused by radiographically detectable brainstem demyelination occurring as a clinically isolated demyelinating syndrome.
abstract: BACKGROUND
  Demyelinating brainstem lesions often causing ophthalmoplegia may occur as the first manifestation of a clinically isolated demyelinating syndrome (CIS). CIS could be the initial attack of clinically definite multiple sclerosis (CDMS) should a second symptomatic attack occur. We report a series of patients with ophthalmoplegia occurring as CIS and assess potential factors affecting the clinical course and final outcome.
  
  
  METHODS
  A computer search was performed for patients evaluated in a university academic neurology practice to identify those with the diagnosis of diplopia. Selection was then made of patients who met the criteria for CIS, and these individuals formed the basis of this study.
  
  
  RESULTS
  Ten of 327 patients presenting with diplopia fulfilled inclusion criteria. Of these, all had ophthalmoplegia in primary position of gaze or symptomatic internuclear ophthalmoplegia, and all recovered irrespective of brain MRI findings, steroid use, presence of oligoclonal bands, or progression to CDMS.
  
  
  CONCLUSIONS
  The ophthalmoplegia of CIS tends to improve with time, regardless of later progression to CDMS. More analysis is needed to fully understand this unique presentation of demyelination.
authors.affiliation: Department of Neurology and Neuro-Ophthalmology, University of Illinois College of Medicine at Peoria, 530 NE Glen Oak Avenue, Peoria, IL 61637, USA. kattahj@uicomp.uic.edu
authors.forename: John H
authors.initials: JH
authors.lastname: Pula
authors.forename: Kyle
authors.initials: K
authors.lastname: Brock
authors.forename: Jorge C
authors.initials: JC
authors.lastname: Kattah
mesh_terms: D000293:Adolescent; D000328:Adult; D001933:Brain Stem / Q000473:pathology* / Q000503:physiopathology*; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009886:Ophthalmoplegia / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology*; D012189:Retrospective Studies; D055815:Young Adult