title: Delayed cord clamping and blood flow in the superior vena cava in preterm infants: an observational study.
abstract: OBJECTIVE
  To determine if timing of cord clamping affects blood flow in the upper body, as measured by flow in the superior vena cava (SVC).
  
  
  METHODS
  Observational study.
  
  
  METHODS
  Neonatal Unit, Middlemore Hospital, Auckland, New Zealand.
  
  
  METHODS
  30 preterm infants <30 weeks' gestational age.
  
  
  METHODS
  Cord clamping was immediate in 17 infants and delayed by 30-45 s in 13.
  
  
  RESULTS
  Infants in the two groups did not differ significantly in terms of gestational age, gender or use of antenatal steroids. Median flow in the SVC in the first 24 h was significantly higher in the group with delayed clamping (median 91 ml/kg/min; IQR 81-101) compared with 52 ml/kg/min (IQR 42-100) in the immediate clamping group (p=0.028). Fewer infants in the delayed group had low flow (1 compared with 9; p=0.017). All three infants with intraventricular haemorrhage (IVH) (of any grade) had low flow.
  
  
  CONCLUSIONS
  Blood flow in the SVC was higher in infants where delayed cord clamping was performed. The relationship of IVH, low flow and timing of cord clamping requires further study.
authors.affiliation: Kidz First, Middlemore Hospital, Auckland, New Zealand. mmeyer@middlemore.co.nz
authors.forename: Michael P
authors.initials: MP
authors.lastname: Meyer
authors.forename: Lindsay
authors.initials: L
authors.lastname: Mildenhall
mesh_terms: D001783:Blood Flow Velocity; D003250:Constriction; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D009520:New Zealand; D019370:Observation; D013997:Time Factors; D014470:Umbilical Cord; D014683:Vena Cava, Superior / Q000502:physiology*