title: [POEMS syndrome diagnosed by detection of M-protein on immunofixation and increased level of vascular endothelial growth factor].
abstract: A 48-year-old male with Castleman disease developed symptoms typical of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal-protein and skin changes) but M-protein was not detected by immunoelec-trophoresis. He was diagnosed as having POEMS syndrome based on IgA-λ detected by immunofixation electrophoresis and an increased level (3,170 pg/ml) of vascular endothelial growth factor (VEGF). After diagnosis, the patient underwent autologous peripheral blood stem cell transplantation safely and remained relapse-free and in good condition for 15 months. This case suggests that immunofixation electrophoresis and detection of elevated serum VEGF level are useful methods for earlier diagnosis of POEMS syndrome.
authors.affiliation: Department of Hematology, Japan Red Cross Shizuoka Hospital.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Hattori
authors.forename: Jun
authors.initials: J
authors.lastname: Taguchi
authors.forename: Noboru
authors.initials: N
authors.lastname: Imai
authors.forename: Koichiro
authors.initials: K
authors.lastname: Wasano
authors.forename: Shiro
authors.initials: S
authors.lastname: Matsuura
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Koharazawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
authors.forename: Shin
authors.initials: S
authors.lastname: Fujisawa
mesh_terms: D015415:Biomarkers / Q000097:blood; D042241:Early Diagnosis; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000175:diagnosis*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D015415:Biomarkers; D006023:Glycoproteins; D042461:Vascular Endothelial Growth Factor A; C023587:protein M (glycoprotein)