title: How well can fragments explore accessed chemical space? A case study from heat shock protein 90.
authors.affiliation: Vernalis (R&D) Ltd., Granta Park, Abington, Cambridge, CB21 6GB, UK.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Roughley
authors.forename: Roderick E
authors.initials: RE
authors.lastname: Hubbard
mesh_terms: D001665:Binding Sites; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D011485:Protein Binding; D054852:Small Molecule Libraries / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D018841:HSP90 Heat-Shock Proteins; D008024:Ligands; D054852:Small Molecule Libraries