title: Transmembrane collagen receptors.
abstract: Collagen, the most abundant protein in animals, is a key component of extracellular matrices. Not only do collagens provide essential structural support for connective tissues, but they are also intimately involved in controlling a spectrum of cellular functions such as growth, differentiation, and morphogenesis. All collagens possess triple-helical regions through which they interact with a host of other proteins including cell surface receptors. A structurally diverse group of transmembrane receptors mediates the recognition of the collagen triple helix: integrins, discoidin domain receptors, glycoprotein VI, and leukocyte-associated immunoglobulin-like receptor-1. These collagen receptors regulate a wide range of behaviors including cell adhesion and migration, hemostasis, and immune function. Here these collagen receptors are discussed in terms of their molecular basis of collagen recognition, their signaling and developmental functions, and their roles in disease.
authors.affiliation: National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom. b.leitinger@imperial.ac.uk
authors.forename: Birgit
authors.initials: B
authors.lastname: Leitinger
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D003094:Collagen / Q000737:chemistry / Q000378:metabolism; D019143:Evolution, Molecular; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D015539:Platelet Activation; D010980:Platelet Membrane Glycoproteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism; D011487:Protein Conformation; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism; D038981:Receptors, Collagen / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D016023:Integrins; D010980:Platelet Membrane Glycoproteins; D038981:Receptors, Collagen; D011971:Receptors, Immunologic; C108073:leukocyte-associated immunoglobulin-like receptor 1; C098341:platelet membrane glycoprotein VI; D003094:Collagen; D020794:Receptor Protein-Tyrosine Kinases