title: YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention.
abstract: Surprisingly little is known about the underlying genetic events that trigger the progression of a normal cell into a cancerous cell. We recently developed a YB-1-driven model of pre-malignancy where we uncovered that the oncogene promotes genomic instability through cell cycle checkpoint slippage and centrosome amplification. In this research perspective, we describe a possible mechanism by which YB-1 instigates preneoplastic transformation. Using Kinex antibody microarrays with coverage of 800 proteins, we discovered that pre-malignant cells exhibit deregulated signal transduction along the HER2-MAPK-RSK axis. We will discuss the implications of these finding in regard to early intervention strategies.
authors.affiliation: Laboratory of Oncogenomic Research, Departments of Pediatrics and Experimental Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada.
authors.forename: Alastair H
authors.initials: AH
authors.lastname: Davies
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Dunn
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000503:physiopathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D018450:Disease Progression; D053263:Gene Regulatory Networks; D020022:Genetic Predisposition to Disease; D006801:Humans; D020935:MAP Kinase Signaling System / Q000235:genetics; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000639:trends; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D038744:Ribosomal Protein S6 Kinases, 90-kDa / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D051840:Y-Box-Binding Protein 1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D038744:Ribosomal Protein S6 Kinases, 90-kDa; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human; C508053:ERBB2 protein, human; C069329:RPS6KA1 protein, human