title: Possible association of nm23 gene-expression and ki-ras point mutations with metastatic potential in human pancreatic cancer-derived cell-lines.
abstract: Nm23 gene expression and Ki-ras point mutations of eight human pancreatic cancer-derived cell lines with different metastatic capabilities were studied. Nm23 gene expression was significantly reduced in the cell lines with a high metastatic potential as compared with those with a low meta static potential (p<0.05). The same mutation at codon 12 of the Ki-ras gene (Gly12 to Asp12) was found in all cell lines with a high metastatic potential. These findings suggest a possible association of metastatic potential with Nm23 gene expression as well as the mutation of Ki-ras gene in human pancreatic cancer.
authors.affiliation: NATL KYUSHU CANC CTR,RES INST,FUKUOKA,JAPAN. NATL CANC CTR,RES INST,DIV BIOL,TOKYO 104,JAPAN. NIH,PATHOL LAB,BETHESDA,MD 20892.
authors.forename: D
authors.initials: D
authors.lastname: Yasuda
authors.forename: H
authors.initials: H
authors.lastname: Iguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: S
authors.initials: S
authors.lastname: Nishimura
authors.forename: P
authors.initials: P
authors.lastname: Steeg
authors.forename: T
authors.initials: T
authors.lastname: Misawa
authors.forename: H
authors.initials: H
authors.lastname: Nawata
authors.forename: A
authors.initials: A
authors.lastname: Kono