title: National Cancer Institute Prostate Cancer Genetics Workshop.
abstract: Compelling evidence supports a genetic component to prostate cancer susceptibility and aggressiveness. Recent genome-wide association studies have identified more than 30 single-nucleotide polymorphisms associated with prostate cancer susceptibility. It remains unclear, however, whether such genetic variants are associated with disease aggressiveness--one of the most important questions in prostate cancer research today. To help clarify this and substantially expand research in the genetic determinants of prostate cancer aggressiveness, the first National Cancer Institute Prostate Cancer Genetics Workshop assembled researchers to develop plans for a large new research consortium and patient cohort. The workshop reviewed the prior work in this area and addressed the practical issues in planning future studies. With new DNA sequencing technology, the potential application of sequencing information to patient care is emerging. The workshop, therefore, included state-of-the-art presentations by experts on new genotyping technologies, including sequencing and associated bioinformatics issues, which are just beginning to be applied to cancer genetics.
authors.affiliation: Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. wcatalona@nmff.org
authors.forename: William J
authors.initials: WJ
authors.lastname: Catalona
authors.forename: Joan E
authors.initials: JE
authors.lastname: Bailey-Wilson
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Camp
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Cooney
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Eeles
authors.forename: Liesel M
authors.initials: LM
authors.lastname: FitzGerald
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Freedman
authors.forename: Julius
authors.initials: J
authors.lastname: Gudmundsson
authors.forename: Rick A
authors.initials: RA
authors.lastname: Kittles
authors.forename: Elliott H
authors.initials: EH
authors.lastname: Margulies
authors.forename: Barry B
authors.initials: BB
authors.lastname: McGuire
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Ostrander
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Rebbeck
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stanford
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Thibodeau
authors.forename: John S
authors.initials: JS
authors.lastname: Witte
authors.forename: William B
authors.initials: WB
authors.lastname: Isaacs
mesh_terms: D019295:Computational Biology / Q000379:methods; D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D054547:National Cancer Institute (U.S.); D009316:National Institutes of Health (U.S.); D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014481:United States