title: Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies.
abstract: Our aim in this study was to investigate the association between elevated homocysteine levels and the two MTHFR polymorphisms, C677T and A1298C, with several pregnancy complications such as recurrent pregnancy loss, preeclampsia, placental abruption and intrauterine growth retardation. In 203 women with different placental vasculopathies, we determined the MTHFR C677T and the A1298C prevalence and their relative association to elevated homocysteine levels. The mean plasma homocysteine level was significantly higher in the pathologic groups when compared with the control group. We identified the carriage of the MTHFR A1298C polymorphism as a significant risk factor for vascular-related pregnancy complications. Women with MTHFR A1298C polymorphism or elevated homocysteine levels have an increased risk of placental vasculopathies. The MTHFR A1298C mutation also had a positive impact on elevated homocysteine levels. The lack of association between the MTHFR C677T polymorphism and pregnancy morbidities needs further studies.
authors.affiliation: Laboratory of Molecular Biology, Department of Hematology, Rabta University Hospital, Tunis, Tunisia.
authors.forename: Sarra
authors.initials: S
authors.lastname: Klai
authors.forename: Najiba
authors.initials: N
authors.lastname: Fekih-Mrissa
authors.forename: Sonia
authors.initials: S
authors.lastname: El Housaini
authors.forename: Naziha
authors.initials: N
authors.lastname: Kaabechi
authors.forename: Brahim
authors.initials: B
authors.lastname: Nsiri
authors.forename: Radhouen
authors.initials: R
authors.lastname: Rachdi
authors.forename: Nasredine
authors.initials: N
authors.lastname: Gritli
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D010920:Placenta / Q000098:blood supply*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D015995:Prevalence; D014652:Vascular Diseases / Q000453:epidemiology / Q000235:genetics*
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)