title: [The clinical and diagnostic value of biochemical parameters for the evaluation of type 2 diabetes compensation].
abstract: The study was undertaken to evaluate the magnitude of oxidative stress and enzymatic antioxidant defense in patients with type 2 diabetes (T2D) in the stages of subcompensation and decompensation. T2D was found to be characterized by the development of oxidative stress that was more evident in its decompensated form. The altered activity of glucose-6-phosphate dehydrogenase can serve as a biochemical marker of the degree of hyperglycemia compensation. It is obvious that the complex analysis of not only the level of glycated hemoglobin, but also the activity of antioxidant defense enzymes is necessary for providing an objective evaluation of the antioxidant status of these patients.
authors.forename: Z I
authors.initials: ZI
authors.lastname: Mikashinovich
authors.forename: O G
authors.initials: OG
authors.lastname: Ishonina
authors.forename: E V
authors.initials: EV
authors.lastname: Olempieva
mesh_terms: D002374:Catalase / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology*; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D006454:Hemoglobins; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione