title: Pharmacokinetic profile in late pregnancy and cord blood concentration of tipranavir and enfuvirtide.
abstract: The data on the use of tipranavir and enfuvirtide in pregnancy are very limited. We performed a pharmacokinetic profile in a pregnant woman with multidrug-resistant HIV-1 infection at 37 weeks gestation. Tipranavir levels were in the therapeutic range and the cord blood concentration at delivery was relatively high when compared with other protease inhibitors. No enfuvirtide was detected in the fetal compartment. Tipranavir and enfuvirtide were successfully used in pregnancy, but possible toxicities must be kept in mind.
authors.affiliation: Department of Obstetrics, Charité Universitätsmedizin Berlin, Germany. katharina.weizsaecker@charite.de
authors.forename: K
authors.initials: K
authors.lastname: Weizsaecker
authors.forename: M
authors.initials: M
authors.lastname: Kurowski
authors.forename: B
authors.initials: B
authors.lastname: Hoffmeister
authors.forename: D
authors.initials: D
authors.lastname: Schürmann
authors.forename: C
authors.initials: C
authors.lastname: Feiterna-Sperling
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000077560:Enfuvirtide; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D015700:HIV Envelope Protein gp41 / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D010446:Peptide Fragments / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010949:Plasma / Q000737:chemistry*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011725:Pyridines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011753:Pyrones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013449:Sulfonamides
chemical_list: D019380:Anti-HIV Agents; D015700:HIV Envelope Protein gp41; D010446:Peptide Fragments; D011725:Pyridines; D011753:Pyrones; D013449:Sulfonamides; D000077560:Enfuvirtide; C107201:tipranavir