title: Anti-Mullerian hormone and antral follicle count as predictors for embryo/oocyte cryopreservation cycle outcomes in breast cancer patients stimulated with letrozole and follicle stimulating hormone.
abstract: OBJECTIVE
  To predict embryo/oocyte cryopreservation cycle (ECC) outcomes in breast cancer patients stimulated with letrozole and follicle stimulating hormone for fertility preservation based on observed anti-mullerian hormone (AMH) levels and antral follicle counts (AFC).
  
  
  METHODS
  The correlation between AMH and AFC and ECC outcomes were analyzed retrospectively on forty one women with breast cancer before adjuvant treatment.
  
  
  RESULTS
  AMH and AFC had a stronger correlation with the total number of oocytes and the number of mature oocytes than age, FSH, and inhibin B. Subjects were evaluated by the number of mature oocytes retrieved to create cutoff points of AMH level, which identified 1.2 ng/mL as a potential value. Seven of 18 patients with AMH levels ≤1.2 ng/mL had low response versus none of 23 with >1.2 ng/mL, (p = 0.001).
  
  
  CONCLUSIONS
  AMH is the most reliable serum marker of ECC outcomes, together with AFC as a biophysical marker, in breast cancer patients. Low response is highly likely when the AMH level is ≤1.2 ng/mL.
authors.affiliation: Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Lee
authors.forename: Sinan
authors.initials: S
authors.lastname: Ozkavukcu
authors.forename: Elke
authors.initials: E
authors.lastname: Heytens
authors.forename: Fred
authors.initials: F
authors.lastname: Moy
authors.forename: Rose M
authors.initials: RM
authors.lastname: Alappat
authors.forename: Kutluk
authors.initials: K
authors.lastname: Oktay
mesh_terms: D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D001943:Breast Neoplasms / Q000503:physiopathology*; D015925:Cryopreservation; D047108:Embryonic Development / Q000502:physiology; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D015571:Follicular Fluid / Q000166:cytology*; D005500:Follow-Up Studies; D006801:Humans; D007265:Inhibins / Q000097:blood; D000077289:Letrozole; D009570:Nitriles / Q000008:administration & dosage*; D009865:Oocytes / Q000166:cytology / Q000254:growth & development; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*
chemical_list: D009570:Nitriles; D014230:Triazoles; C422364:inhibin B; D007265:Inhibins; D000077289:Letrozole; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone