title: Potential selective advantage mechanism for polymorphic genetics in celiac disease.
abstract: Celiac Disease is a common cause of morbidity in the developed world but its etiology is still unknown. Considering that Celiac Disease was first documented in Scandinavian Europe, a population exposed to a high fat diet, perhaps the polymorphic genetics of the disease provides balanced polymorphism against this environmental stimulus. Celiac Disease has been associated with higher levels of the T cell receptor (TCR)γδ, receptors that have played a greater role in recognizing microbial lipids. Furthermore, obesity has been associated with lower levels of CD-3 expression while Celiac Disease has been associated with an up regulation of this molecule. These finding might help to describe a balance polymorphism that exists in Celiac Disease as well as an etiological factor that lead to the development of the disease.
authors.affiliation: Department of Pathology, Touro College of Osteopathic Medicine, 230 West 125th Street, New York, NY 10027, USA. joel.david@student.touro.edu
authors.forename: Joel
authors.initials: J
authors.lastname: David
authors.forename: Bhavesh
authors.initials: B
authors.lastname: Mody
mesh_terms: D002446:Celiac Disease / Q000235:genetics* / Q000276:immunology; D006801:Humans; D011110:Polymorphism, Genetic; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta