title: Clonal chromosome-aberrations in fibrocystic breast disease-associated with increased risk of cancer.
abstract: Short-term cultures of 29 samples of fibrocystic breast disease were cytogenetically analyzed. Clonal chromosome aberrations were found in six specimens, whereas the remaining 23 had a normal karyotype. Three of the abnormal samples displayed karyotypic anomalies previously associated with breast cancer, i.e., gain of Iq, trisomy 18 and cytogenetic multiclonality. Furthermore, all cytogenetically aberrant specimens had either proliferative disease without atypia or atypical hyperplasia, features of fibrocystic disease considered risk factors for subsequent breast cancer development. The cytogenetic similarities between breast carcinomas and proliferative fibrocystic breast disease add further support for classifying certain types of fibrocystic disease as a premalignant condition. Whether cytogenetically abnormal fibrocystic lesions are the ones that subsequently progress to cancer remains to be elucidated.
authors.affiliation: UNIV LUND HOSP,DEPT SURG,S-22185 LUND,SWEDEN. UNIV LUND HOSP,DEPT CLIN PATHOL,S-22185 LUND,SWEDEN.
authors.forename: C
authors.initials: C
authors.lastname: Petersson
authors.forename: B
authors.initials: B
authors.lastname: Johansson
authors.forename: N
authors.initials: N
authors.lastname: Pandis
authors.forename: L
authors.initials: L
authors.lastname: Gorunova
authors.forename: C
authors.initials: C
authors.lastname: Ingvar
authors.forename: I
authors.initials: I
authors.lastname: Idvall
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: F
authors.initials: F
authors.lastname: Mitelman