title: Sesquiterpene and norsesquiterpene derivatives from Sanicula lamelligera and their biological evaluation.
abstract: Fourteen sesquiterpene and norsesquiterpene derivatives, comprising six different carbon skeletons, were isolated from Sanicula lamelligera. Saniculamoid A1 (1a) is an oxidation product of saniculamoid A (1), created by the transition of a formyl group to a carboxylic acid group after a period of storage in air. The known compounds 5-14 were identified in Sanicula plants for the first time. The compounds were evaluated for their anti-HIV-1, cytostatic, and nitric-oxide-production-inhibiting activities using in vitro cellular assays. The results showed that 1,5-naphthalenediol inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC₅₀ value of 28.1 μM and was active toward five cancer cell lines with IC₅₀ values in the 31.1-41.6 μM range.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Zhou
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Jia
authors.initials: J
authors.lastname: Su
authors.forename: Xue-Jing
authors.initials: XJ
authors.lastname: Li
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yan
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D030005:Sanicula / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C561443:saniculamoid A; C561442:saniculamoid A1; D009569:Nitric Oxide