title: Effect of creatine supplementation on measured glomerular filtration rate in postmenopausal women.
abstract: We aimed to investigate whether creatine supplementation affects the measured glomerular filtration rate in postmenopausal women (age, 58 ± 3 years). Subjects were randomly assigned to receive either creatine (20 g·day(-1) for 1 week and 5 g·day(-1) thereafter) or a placebo. Kidney function was assessed at baseline and after 12 weeks. [(51)Cr]EDTA clearance remained unchanged (CR-PRE: 86.16 ± 14.36 mL·min(-1) per 1.73 m(2), POST: 87.25 ± 17.60 mL·min(-1) per 1.73 m(2); PL-PRE: 85.15 ± 8.54 mL·min(-1) per 1.73 m(2), POST: 87.18 ± 9.64 mL·min(-1) per 1.73 m(2); p = 0.81). Thus, we concluded that creatine supplementation does not affect glomerular filtration rate in postmenopausal women.
authors.affiliation: Division of Rheumatology, School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Manoel
authors.initials: M
authors.lastname: Neves
authors.forename: Bruno
authors.initials: B
authors.lastname: Gualano
authors.forename: Hamilton
authors.initials: H
authors.lastname: Roschel
authors.forename: Fernanda Rodrigues
authors.initials: FR
authors.lastname: Lima
authors.forename: Ana
authors.initials: A
authors.lastname: Lúcia de Sá-Pinto
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Seguro
authors.forename: Maria Heloisa
authors.initials: MH
authors.lastname: Shimizu
authors.forename: Marcelo Tatit
authors.initials: MT
authors.lastname: Sapienza
authors.forename: Ricardo
authors.initials: R
authors.lastname: Fuller
authors.forename: Antonio Herbert
authors.initials: AH
authors.lastname: Lancha
authors.forename: Eloisa
authors.initials: E
authors.lastname: Bonfá
mesh_terms: D003401:Creatine / Q000008:administration & dosage* / Q000494:pharmacology*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause
chemical_list: D003401:Creatine