title: [Characteristics of neurohumoral regulation of stomach in aging].
abstract: The neurohumoral regulation of the motor-secretory activity of the rabbit's and rat's stomach during aging was studied. The aim--to reveal the nature of interaction between the serotoninergic, adrenergic and cholinergic divisions of vegetative nervous system (VNS) in the regulation of motor activity of the aged rodents--rabbits and rats.
  
  
  RESULTS
  It is shown that aging is accompanied with a change in the balance between adrenergic, cholinergic and serotoninergic divisions of the VNS. Adrenergic division's contribution in the regulation of gastric motility was lowered, cholinergic's--was slowly reduced and serotoninergic's was relatively increased. Serotoninergic system enhances vagal stimulated uprise of gastric motor activity; serotoninergic system may partially compensate the age-dependent decline of the role of the cholinergic system in the regulation of gastric motility. The stimulation of the vagus nerve induced serotonin secretion by EC-cells of the rat stomach. The stimulation of the vagus nerve decreases the EC-cells volume in aged rots.
authors.forename: L B
authors.initials: LB
authors.lastname: Lazebnik
authors.forename: A É
authors.initials: AÉ
authors.lastname: Lychkova
authors.forename: S G
authors.initials: SG
authors.lastname: Khomeriki
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D005769:Gastrointestinal Motility / Q000502:physiology*; D008297:Male; D011817:Rabbits; D051381:Rats; D013270:Stomach / Q000294:innervation / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology*; D055536:Vagus Nerve Stimulation / Q000379:methods