title: P-glycoprotein expression in non-hodgkins-lymphoma.
abstract: Tissues from twenty-nine patients with non-Hodgkin's lymphoma (NHL) were examined for the presence of the P-glycoprotein (Pgp), a transmembrane protein associated with multidrug resistance. Six of the 29 NHL (21%) expressed Pgp; 3 of 8 (38%) low grade and 3 of 16 (19%) intermediate grade. No relationship was found between Pgp expression and age, stage, lactate dehydrogenase levels, extranodal disease or previous chemotherapy exposure. Pgp was present in 3 of 13 (23%) complete responders and 3 of 11 (27%) partial or nonresponders (p>0.10) suggesting no direct association between treatment response and Pgp expression in this series.
authors.affiliation: VICTORIA HOSP,DEPT HEMATOL,375 SOUTH ST,LONDON N6A 4G5,ONTARIO,CANADA. UNIV WESTERN ONTARIO,DEPT BIOSTATIST & EPIDEMIOL,LONDON N6A 4G5,ON,CANADA. VICTORIA HOSP,DEPT PATHOL,LONDON N6A 4G5,ONTARIO,CANADA. HARPER GRACE HOSP,DEPT PATHOL,DETROIT,MI 48201.
authors.forename: R
authors.initials: R
authors.lastname: West
authors.forename: E
authors.initials: E
authors.lastname: Boyle
authors.forename: D
authors.initials: D
authors.lastname: Grignon
authors.forename: I
authors.initials: I
authors.lastname: Chinyee