title: Use of pluronic micelles to overcome multidrug-resistance.
abstract: Pluronic P-85 (poly(55)(oxypropylene)dipoly(s)(oxyethylene)) was used to form daunorubicin containing micelles. This new carrier was tested in vitro on sensitive and resistant ovarian cancer cell lines. Drug incorporation was measured by cytofluorometry and the cytotoxicity was measured by the tetrazolium formazan XTT assay. ID50 of 0.16 and 25 mu g/ml were obtained for conjugated and free daunorubicin respectively. The results obtained suggest that this approach may be used in combination with a chemotherapeutic agent to overcome multidrug resistance.
authors.affiliation: UNIV LAVAL,FAC MED,DEPT BIOCHEM,ST FOY G1K 7P4,PQ,CANADA.
authors.forename: R
authors.initials: R
authors.lastname: Paradis
authors.forename: C
authors.initials: C
authors.lastname: Noel
authors.forename: M
authors.initials: M
authors.lastname: Page