title: Electrochemical detection of DNA mutations on a PNA-modified electrode utilizing a single-stranded DNA specific endonuclease.
abstract: Utilizing a peptide nucleic acid (PNA)-modified electrode and a single-stranded DNA specific endonuclease, a novel electrochemical method to identify DNA mutations has been developed and represents a totally new strategy for the electrochemical diagnosis of human genetic mutations.
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK21 Program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea.
authors.forename: Sujeong
authors.initials: S
authors.lastname: Shin
authors.forename: Byoung Yeon
authors.initials: BY
authors.lastname: Won
authors.forename: Cheulhee
authors.initials: C
authors.lastname: Jung
authors.forename: Sung Chul
authors.initials: SC
authors.lastname: Shin
authors.forename: Dae Yeon
authors.initials: DY
authors.lastname: Cho
authors.forename: Soo Suk
authors.initials: SS
authors.lastname: Lee
authors.forename: Hyun Gyu
authors.initials: HG
authors.lastname: Park
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics; D020137:Base Pair Mismatch; D004247:DNA / Q000032:analysis* / Q000235:genetics; D004277:DNA, Single-Stranded / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D004720:Endonucleases / Q000378:metabolism*; D005292:Ferricyanides / Q000737:chemistry; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D020641:Polymorphism, Single Nucleotide
chemical_list: D019313:BRCA1 Protein; D004277:DNA, Single-Stranded; D005292:Ferricyanides; D020135:Peptide Nucleic Acids; C007931:hexacyanoferrate III; D004247:DNA; D004720:Endonucleases