title: De novo synthesis of natural products via the asymmetric hydration of polyenes.
abstract: For the last ten years our group has been working toward the development of an asymmetric hydration approach to polyketide natural products based on the regioselective hydration of di- and tri-enoates. Key to the success of this approach is the recognition that both high regiocontrol and asymmetric induction could be obtained by the use of a Sharpless asymmetric dihydroxylation reaction. Herein we describe the development of the method and its application to natural product total synthesis.
authors.affiliation: Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Wang
authors.forename: Yalan
authors.initials: Y
authors.lastname: Xing
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: George A
authors.initials: GA
authors.lastname: O'Doherty
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D002384:Catalysis; D010084:Oxidation-Reduction; D011090:Polyenes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011090:Polyenes; C117813:apicularen A