title: A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families.
abstract: OBJECTIVE
  The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking.
  
  
  METHODS
  Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pairs design, the authors conducted nonparametric linkage analysis.
  
  
  RESULTS
  In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25).
  
  
  CONCLUSIONS
  Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.
authors.affiliation: Department of Psychiatry, WashingtonUniversity School of Medicine, Saint Louis, MO 63110, USA. pergadim@psychiatry.wustl.edu
authors.forename: Michele L
authors.initials: ML
authors.lastname: Pergadia
authors.forename: Anne L
authors.initials: AL
authors.lastname: Glowinski
authors.forename: Naomi R
authors.initials: NR
authors.lastname: Wray
authors.forename: Arpana
authors.initials: A
authors.lastname: Agrawal
authors.forename: Scott F
authors.initials: SF
authors.lastname: Saccone
authors.forename: Anu
authors.initials: A
authors.lastname: Loukola
authors.forename: Ulla
authors.initials: U
authors.lastname: Broms
authors.forename: Tellervo
authors.initials: T
authors.lastname: Korhonen
authors.forename: Brenda W J H
authors.initials: BW
authors.lastname: Penninx
authors.forename: Julia D
authors.initials: JD
authors.lastname: Grant
authors.forename: Elliot C
authors.initials: EC
authors.lastname: Nelson
authors.forename: Anjali K
authors.initials: AK
authors.lastname: Henders
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Schrage
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Chou
authors.forename: Kaisu
authors.initials: K
authors.lastname: Keskitalo-Vuokko
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhu
authors.forename: Scott D
authors.initials: SD
authors.lastname: Gordon
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Vink
authors.forename: Eco J C
authors.initials: EJ
authors.lastname: de Geus
authors.forename: Stuart
authors.initials: S
authors.lastname: Macgregor
authors.forename: Jimmy Z
authors.initials: JZ
authors.lastname: Liu
authors.forename: Gonneke
authors.initials: G
authors.lastname: Willemsen
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Medland
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
authors.forename: Grant W
authors.initials: GW
authors.lastname: Montgomery
authors.forename: John P
authors.initials: JP
authors.lastname: Rice
authors.forename: Alison M
authors.initials: AM
authors.lastname: Goate
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Heath
authors.forename: Jaakko
authors.initials: J
authors.lastname: Kaprio
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.forename: Pamela A F
authors.initials: PA
authors.lastname: Madden
mesh_terms: D000328:Adult; D000483:Alleles; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004200:Diseases in Twins / Q000235:genetics*; D005387:Finland; D008040:Genetic Linkage / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008126:Lod Score; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011793:Queensland; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D012907:Smoking / Q000235:genetics* / Q000523:psychology
chemical_list: D018094:Receptors, Metabotropic Glutamate; C102719:metabotropic glutamate receptor 7