title: Effect of sex hormones on crystal formation in a stone-forming rat model.
abstract: Sex hormones have substantial effects on crystal formation in the rat kidney through oxalate metabolism and oxidative cell damage. Testosterone is a promoter and estradiol an inhibitor of such crystal formation. The development of new medications related to sex hormones or GO are anticipated for sufferers of recurrent urolithiasis.
authors.affiliation: Osaka University Graduate School of Medicine, Suita, Japan. yoshioka@uro.med.osaka-u.ac.jp
authors.forename: Iwao
authors.initials: I
authors.lastname: Yoshioka
authors.forename: Masao
authors.initials: M
authors.lastname: Tsujihata
authors.forename: Akihiko
authors.initials: A
authors.lastname: Okuyama
mesh_terms: D000818:Animals; D003460:Crystallization; D004195:Disease Models, Animal; D004958:Estradiol / Q000494:pharmacology / Q000502:physiology*; D005260:Female; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000494:pharmacology / Q000502:physiology*; D052878:Urolithiasis / Q000209:etiology*
chemical_list: D013739:Testosterone; D004958:Estradiol