title: [Expression and clinical significance of VEGF in tissue of primary hepatocellular carcinoma].
abstract: OBJECTIVE
  To study the expression and clinical significance of vaseular endothelial growth factor (VEGF) in tissue of primary hepatocellular carcinoma (PHC) and effects on tumor invasion and metastasis.
  
  
  METHODS
  The VEGF expression from 60 cases of PHC tissues, 30 cases of adjacent tissues and 30 cases of normal tissue were detected by SP immunohistochemical method.
  
  
  RESULTS
  The VEGF positive rate of the PHC group was 68.3%, the adjacent tissues group was 40.0%, and the normal tissue group was 33.3%, compared the different was significant (P<0.05); The VEGF positive rate of the incomplete capsule tissues was 92.9%, which was significantly higher than the complete capsule tissues (P<0.05); and the VEGF positive rate was no significantly different among the different TNM stage, different degree of tumor differentiation and different lesion size (P<0.05).
  
  
  CONCLUSIONS
  The VEGF has high expression in PHC tissues. The VEGF expression has close relation with the whether tumor capsule and distant metastasis. The VEGF plays an important role angiogenesis of PHC, growth and metastasis.
authors.affiliation: Department of Oncology, Affiliated Huaian First Hospital of Nanjing Medical University, Jiansu Huaian, China. zhangdahong731@163.com
authors.forename: Da-hong
authors.initials: DH
authors.lastname: Zhang
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Zhu
authors.forename: Shun
authors.initials: S
authors.lastname: Yue
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism*
chemical_list: D042442:Vascular Endothelial Growth Factors