title: Effects of dan wei powder tea bag on aggregation of blood platelet in vivo and in vitro.
abstract: OBJECTIVE
  To observe effects of Dan Wei Powder (Powder for treating the gall bladder and stomach) Tea Bag (DWSTB) on the aggregation rate of blood platelet in vivo and in vitro.
  
  
  METHODS
  Increase of the platelet aggregation rate in the rat in vivo was induced by carrageenin, and increase of the rabbit platelet aggregation rate in vitro was induced by adenosine diphosphate (ADP) and collagen, respectively. The effects of DWSTB on the platelet aggregation rate were investigated in vivo and in vitro, respectively.
  
  
  RESULTS
  The maximum in vivo platelet aggregation rate in the rat was significantly decreased after administration of 2.0 and 4.0 g x kg(-1) DWSTB (P < 0.05, P < 0.01). The maximum rabbit platelet aggregation rate induced by ADP and collagen in vitro were suppressed significantly by 2.0-16.0 mg x mL(-1) and 2.0-8.0 mg x mL(-1) DWSTB, respectively (P < 0.05, P < 0.01). And the effect of DWSTB on platelet aggregation was raised with increase of its dose.
  
  
  CONCLUSIONS
  Dan Wei Powder Tea Bag can restrain the aggregation of platelet in vivo and in vitro.
authors.affiliation: The Third People's Hospital of Yuyao, Zhejiang Province, Yuyao 315400, China. Yuyaomso@hotmail.com
authors.forename: Cheng-Lie
authors.initials: CL
authors.lastname: Yu
authors.forename: Qi-Yang
authors.initials: QY
authors.lastname: Shou
authors.forename: Guang-Ya
authors.initials: GY
authors.lastname: Zhu
authors.forename: Guo-You
authors.initials: GY
authors.lastname: Yu
authors.forename: Ri-Qing
authors.initials: RQ
authors.lastname: Xie
authors.forename: Lin-Chao
authors.initials: LC
authors.lastname: Jia
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal