title: Ethnicity differences in plasma apoC-III levels between African American and Caucasian youths.
abstract: BACKGROUND
  Little is known about the association between apoC-III and lipoprotein-lipids in African American (AA) and Caucasian (CA) youths. The aim of this study was to investigate if plasma apoC-III level is associated with ethnicity differences in atherogenic lipoprotein-lipids between AA and CA youths.
  
  
  METHODS
  A total of 202 youths (mean age 16.1±1.3 y, range 13.8-18.9 y) consisting of 122 AA (boys/girls, 52/70) and 80 CA (boys/girls, 40/40) youths were recruited via flyers sent to local high schools. For AA youths, body mass index (BMI) values were 22.5±5.0 kg/m(2) and 25.0±6.8 kg/m(2) for boys and girls, respectively. For CA youths, BMI values were 22.0±4.8 kg/m(2) and 22.1±5.0 kg/m(2) for boys and girls, respectively. Anthropometric variables were measured using standard procedures. Body fat was measured by dual-energy X-ray absorptiometry. Fasting glucose and insulin, lipoprotein-lipids, and apolipoproteins were measured in fasting plasma samples.
  
  
  RESULTS
  AA youths had significantly lower values in apoC-III (P<0.001), triglyceride (P<0.001), and total cholesterol/high-density lipoprotein cholesterol (P=0.011) and higher values in HDLC (P=0.004), apoE (P=0.016), insulin (P=0.027), and homoeostasis model of assessment insulin resistance (HOMA-IR) (P=0.025) than CA youths. Body composition and insulin resistance parameters were significantly associated with apoC-III levels in CA youths, but not in AA youths. Regression analyses showed that waist circumference and HOMA-IR were significant predictors for apoC-III in CA, not AA, youths.
  
  
  CONCLUSIONS
  The findings of the current study suggest that ethnicity differences in atherogenic lipids between AA and CA youths may be associated with differences in apoC-III and apoE levels.
authors.affiliation: Division of Humanities and Social Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Hye-Ryun
authors.initials: HR
authors.lastname: Hong
authors.forename: Hyun-Sik
authors.initials: HS
authors.lastname: Kang
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D001741:Black or African American; D053305:Apolipoprotein C-III / Q000097:blood*; D001057:Apolipoproteins E / Q000097:blood*; D001823:Body Composition; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D014280:Triglycerides / Q000097:blood; D044465:White People
chemical_list: D053305:Apolipoprotein C-III; D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D014280:Triglycerides