title: P-glycoprotein - low constitutional expression does not correlate with treatment failure in follicular lymphomas.
abstract: Tissue P-glycoprotein immunostaining was performed in seventy one patients with follicular large, mixed, or small cell non-Hodgkin's lymphomas. Only six patients (8.5%) demonstrated positive immunostaining for P-glycoprotein. All patients had complete and durable responses to initial therapy. P-glycoprotein (MDR) fails to predict for primary drug resistance in follicular lymphomas and is constitutionally expressed in only a few follicular lymphomas at present.
authors.affiliation: UNIV WITWATERSRAND,SCH MED,DEPT MED,DIV CLIN HAEMATOL & MED ONCOL,YORK RD,JOHANNESBURG 2193,SOUTH AFRICA. JOHANNESBURG HOSP,JOHANNESBURG 2193,SOUTH AFRICA.
authors.forename: L
authors.initials: L
authors.lastname: Seymour
authors.forename: M
authors.initials: M
authors.lastname: Davidgepitts
authors.forename: D
authors.initials: D
authors.lastname: Lewis
authors.forename: W
authors.initials: W
authors.lastname: Bezwoda