title: Responsiveness to metformin in girls with androgen excess: collective influence of genetic polymorphisms.
abstract: OBJECTIVE
  To study the relationship between the responsiveness to metformin in girls with androgen excess and combinations of genetic variants-as reflected in a polymorphism score-in single nucleotide polymorphisms (OCT1, STK11, and FTO genes) and in the repeat numbers within the AR and SHBG genes.
  
  
  METHODS
  Longitudinal (1-year) follow-up.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Hyperandrogenic adolescent girls receiving metformin.
  
  
  METHODS
  Single nucleotide polymorphisms and repeat numbers were assessed in 104 adolescent girls with androgen excess. The polymorphism score was the sum of subscores given for response alleles in OCT1, STK11, and FTO and for high repeat numbers in SHBG and AR alleles.
  
  
  METHODS
  The response to metformin (850 mg/d) was judged by changes over 1 year in endocrine-metabolic state and body composition.
  
  
  RESULTS
  Changes in fasting insulin levels, triacylglycerol levels, LDL-HDL ratio, and body composition differed strikingly by polymorphism score.
  
  
  CONCLUSIONS
  Collectively, genetic polymorphisms had a major influence on the responsiveness to metformin in adolescent girls with androgen excess.
authors.affiliation: Endocrinology Unit, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Díaz
authors.forename: Abel
authors.initials: A
authors.lastname: López-Bermejo
authors.forename: David
authors.initials: D
authors.lastname: Sánchez-Infantes
authors.forename: Judit
authors.initials: J
authors.lastname: Bassols
authors.forename: Francis
authors.initials: F
authors.lastname: de Zegher
authors.forename: Lourdes
authors.initials: L
authors.lastname: Ibáñez
mesh_terms: D000293:Adolescent; D000728:Androgens / Q000097:blood / Q000235:genetics; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000188:drug therapy* / Q000235:genetics*; D008137:Longitudinal Studies; D008687:Metformin / Q000627:therapeutic use*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies
chemical_list: D000728:Androgens; D008687:Metformin