title: The role of shear stress in the pathogenesis of discrete subaortic stenosis: implications for surgical treatment.
abstract: Discrete subaortic stenosis (DSS) is characterized by the presence of an obstructing membrane in the left ventricular outflow tract (LVOT). Evidence suggests that the formation of DSS represents a fibroproliferative reaction of the endocardium occurring in response to alterations in shear stress caused by geometric abnormalities within the LVOT. The aim of this review is to discuss the role of altered LVOT shear stress in the pathogenesis of DSS, and its implications in surgical decision making.
authors.affiliation: Mount Sinai School of Medicine, New York City, NY, USA. jeffrey.silbiger@mssm.edu
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Silbiger
mesh_terms: D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006348:Cardiac Surgical Procedures; D021922:Discrete Subaortic Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D018618:Echocardiography, Doppler, Color; D005355:Fibrosis; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D018579:Patient Selection; D011237:Predictive Value of Tests; D013314:Stress, Mechanical; D016277:Ventricular Function, Left