title: Direct aldol reactions catalyzed by a heterogeneous guanidinium salt/proline system under solvent-free conditions.
abstract: The combined activity of (S)-proline and an achiral cocatalyst (a TBD-derived guanidinium salt) allow direct aldol reactions to be carried out with high diastereoselectivity and enantioselectivity under solvent-free conditions with a rather simple reaction setup where stirring is not required.
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, C/Julian Claveria 8, 33006, Oviedo, Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Martínez-Castañeda
authors.forename: Belén
authors.initials: B
authors.lastname: Poladura
authors.forename: Humberto
authors.initials: H
authors.lastname: Rodríguez-Solla
authors.forename: Carmen
authors.initials: C
authors.lastname: Concellón
authors.forename: Vicente
authors.initials: V
authors.lastname: del Amo
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D053961:Azabicyclo Compounds / Q000737:chemistry; D002384:Catalysis; D019791:Guanidine / Q000737:chemistry*; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D053961:Azabicyclo Compounds; D012492:Salts; C526482:triazabicyclodecene; C116609:3-hydroxybutanal; D011392:Proline; D019791:Guanidine