title: Ring-Opening Metathesis Polymerization-Based Synthesis of CaCO(3) Nanoparticle-Reinforced Polymeric Monoliths for Tissue Engineering.
abstract: Porous monolithic materials have been prepared via ring-opening metathesis polymerization from norborn-2-ene and a 7-oxanorborn-2-ene-based cross-linker in the presence of porogenic solvents (i.e., 2-propanol and toluene) and norborn-2-enephosphonate surface-modified CaCO(3) nanoparticles, using the 3(rd) -generation Grubbs-initiator RuCl(2) (Py)(2) (IMesH(2) )(CHPh). The experimental setup and the conditions chosen allowed for the manufacturing of polymeric monoliths characterized by a homogeneous distribution of the inorganic nanoparticles throughout the polymeric monolith. Depending on the nanoparticle content, the macropore diameters could be varied in the 30-120 µm regime. Noteworthy, the addition of nanoparticles did not affect the phase separation-triggered formation of the monolithic matrix nor the meso- and microporosity as evidenced by N(2) -adsorption experiments.
authors.affiliation: Leibniz-Institut für Oberflächenmodifizierung e. V. IOM, Permoserstrasse 15, D-04318 Leipzig, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Weichelt
authors.forename: Bernhard
authors.initials: B
authors.lastname: Frerich
authors.forename: Solvig
authors.initials: S
authors.lastname: Lenz
authors.forename: Stefanie
authors.initials: S
authors.lastname: Tiede
authors.forename: Michael R
authors.initials: MR
authors.lastname: Buchmeiser