title: [Etomidate can not be recommended to patients with septic shock].
abstract: Due to a low cardiovascular complication rate even in patients with shock, etomidate is often used for intubation. Etomidate inhibits the steroid synthesis. A single bolus injection of etomidate has so far been considered to be safe. However, new investigations have shown that even a single bolus dose of etomidate inhibits the steroid synthesis and is associated with increased mortality in patients with septic shock.
authors.affiliation: Anæstesiologisk-intensiv Afdeling V, Odense Universitetshospital, 5000 Odense C, Denmark. palle.toft@ouh.regionsyddanmark.dk
authors.forename: Palle
authors.initials: P
authors.lastname: Toft
authors.forename: Anders Gadegaard
authors.initials: AG
authors.lastname: Jensen
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects / Q000503:physiopathology; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D005045:Etomidate / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects*; D007442:Intubation, Intratracheal; D012772:Shock, Septic / Q000401:mortality / Q000503:physiopathology / Q000628:therapy
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D005045:Etomidate