title: Effect of lapatinib on hepatic parenchymal enhancement on gadoxetate disodium (EOB)-enhanced MRI scans.
abstract: We present changes seen on hepatobiliary phase (HBP)-gadoxetate disodium (EOB)-enhanced magnetic resonance image of a woman with liver metastases who was treated with lapatinib. After treatment, the HBP images appeared like portal venous phase images. This suggests that lapatinib, an inhibitor of organic anion transporting polypeptide 1B1, one of the substrates of EOB, inhibits EOB uptake by hepatocytes. In patients treated with lapatinib, the ability to diagnose liver tumors on HBP images may be compromised.
authors.affiliation: Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. yukon@hiroshima-u.ac.jp
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Shuji
authors.initials: S
authors.lastname: Date
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Toyota
authors.forename: Chihiro
authors.initials: C
authors.lastname: Tani
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Honda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Komoto
authors.forename: Keizo
authors.initials: K
authors.lastname: Tanitame
authors.forename: Kazuo
authors.initials: K
authors.lastname: Awai
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D000077341:Lapatinib; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D011799:Quinazolines / Q000627:therapeutic use*
chemical_list: D003287:Contrast Media; D011799:Quinazolines; C073590:gadolinium ethoxybenzyl DTPA; D000077341:Lapatinib; D019786:Gadolinium DTPA