title: [Pneumonia due to adenovirus type 7: a case report in a healthy infant].
abstract: A 15-month-old boy treated with amoxicillin and clavulanic acid therapy for 8 days was admitted for persistent gastroenteritis and fever. He received ceftriaxone for pneumonia modified on day 4 for cefotaxime and josamycin due to extension of alveolar lesions. On day 7, persistent fever and worsened respiratory distress led to addition of rifampicin. The child was then admitted to an intensive care unit. A hemophagocytic syndrome was suspected based on clinical signs and laboratory findings and confirmed by cytological examination of bone marrow. Adenovirus type 7 was identified by polymerase chain reaction and culture of bronchoalveolar fluid. Prognosis was good within 3 weeks. B and T immunologic evaluations were normal 5 months after the infection. This case of severe adenovirus pneumonia was associated with hemophagocytic syndrome in a child without identified primary immunodeficiency. Adenovirus type 3 and 7 are most frequently responsible for severe or fatal respiratory infections.
authors.affiliation: Service de pédiatrie, hôpital Louis-Mourier, AP-HP, 178, rue des Renouillers, 92700 Colombes, France. marie-helene.odievre@lmr.aphp.fr
authors.forename: M-H
authors.initials: MH
authors.lastname: Odièvre
authors.forename: N
authors.initials: N
authors.lastname: Danékova
authors.forename: C
authors.initials: C
authors.lastname: Picard
authors.forename: B
authors.initials: B
authors.lastname: Mesples
authors.forename: Z
authors.initials: Z
authors.lastname: BenCheikha
authors.forename: D
authors.initials: D
authors.lastname: Avran
authors.forename: J
authors.initials: J
authors.lastname: De Blic
authors.forename: M
authors.initials: M
authors.lastname: Leruez-Ville
authors.forename: N
authors.initials: N
authors.lastname: Parez
mesh_terms: D000258:Adenovirus Infections, Human / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D000260:Adenoviruses, Human / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007121:Immunocompetence / Q000276:immunology; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008262:Macrophage Activation / Q000276:immunology; D008297:Male; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D016133:Polymerase Chain Reaction; D011379:Prognosis
chemical_list: D000900:Anti-Bacterial Agents