title: Prone position and recruitment manoeuvre: the combined effect improves oxygenation.
abstract: BACKGROUND
  Among the various methods for improving oxygenation while decreasing the risk of ventilation-induced lung injury in patients with acute respiratory distress syndrome (ARDS), a ventilation strategy combining prone position (PP) and recruitment manoeuvres (RMs) can be practiced. We studied the effects on oxygenation of both RM and PP applied in early ARDS patients.
  
  
  METHODS
  We conducted a prospective study. Sixteen consecutive patients with early ARDS fulfilling our criteria (ratio of arterial oxygen partial pressure to fraction of inspired oxygen (PaO2/FiO2) 98.3 ± 28 mmHg; positive end expiratory pressure, 10.7 ± 2.8 cmH2O) were analysed. Each patient was ventilated in both the supine position (SP) and the PP (six hours in each position). A 45 cmH2O extended sigh in pressure control mode was performed at the beginning of SP (RM1), one hour after turning to the PP (RM2) and at the end of the six-hour PP period (RM3).
  
  
  RESULTS
  The mean arterial oxygen partial pressure (PaO2) changes after RM1, RM2 and RM3 were 9.6%, 15% and 19%, respectively. The PaO2 improvement after a single RM was significant after RM3 only (P < 0.05). Improvements in PaO2 level and PaO2/FiO2 ratio were transient in SP but durable during PP. PaO2/FiO2 ratio peaked at 218 mmHg after RM3. PaO2/FiO2 changes were significant only after RM3 and in the pulmonary ARDS group (P = 0.008). This global strategy had a benefit with regard to oxygenation: PaO2/FiO2 ratio increased from 98.3 mmHg to 165.6 mmHg 13 hours later at the end of the study (P < 0.05). Plateau airway pressures decreased after each RM and over the entire PP period and significantly after RM3 (P = 0.02). Some reversible side effects such as significant blood arterial pressure variations were found when extended sighs were performed.
  
  
  CONCLUSIONS
  In our study, interventions such as a 45 cmH2O extended sigh during PP resulted in marked oxygenation improvement. Combined RM and PP led to the highest increase in PaO2/FiO2 ratio without major clinical side effects.
authors.affiliation: Service de pneumologie, Centre Hospitalier Régional et Universitaire de Besançon, 3 Bd. Fleming, Besançon, France. gilles.rival@yahoo.fr
authors.forename: Gilles
authors.initials: G
authors.lastname: Rival
authors.forename: Cyrille
authors.initials: C
authors.lastname: Patry
authors.forename: Nathalie
authors.initials: N
authors.lastname: Floret
authors.forename: Jean Christophe
authors.initials: JC
authors.lastname: Navellou
authors.forename: Evelyne
authors.initials: E
authors.lastname: Belle
authors.forename: Gilles
authors.initials: G
authors.lastname: Capellier
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000737:chemistry; D011175:Positive-Pressure Respiration / Q000379:methods*; D016684:Prone Position / Q000502:physiology*; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000503:physiopathology* / Q000628:therapy*; D016683:Supine Position / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D010100:Oxygen