title: Subretinal recombinant tissue plasminogen activator and pneumatic displacement for the management of subretinal hemorrhage occurring after anti-VEGF injections for wet AMD.
abstract: We describe three cases of submacular hemorrhage that occurred two to four days after anti-VEGF intravitreal injection for occult choroidal neovascularisation in age-related macular degeneration and their management with 25 gauge pars plana vitrectomy with injection of subretinal recombinant tissue plasminogen activator (rTPA) followed by fluid-air exchange and postoperative prone position. Vitrectomy, subretinal rTPA injection and fluid-gas exchange apply as a safe and effective treatment in these cases. Functional results seem to be positive especially if surgical treatment is promptly performed.
authors.affiliation: Eye Clinic, University of Trieste, Trieste, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Tognetto
authors.forename: Eirini
authors.initials: E
authors.lastname: Skiadaresi
authors.forename: Paolo
authors.initials: P
authors.lastname: Cecchini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ravalico