title: Simulation of creep in non-homogenous samples of human cortical bone.
abstract: Characterising the mechanisms causing viscoelastic mechanical properties of human cortical bone, as well as understanding sources of variation, is important in predicting response of the bone to creep and fatigue loads. Any better understanding, when incorporated into simulations including finite element analysis, would assist bioengineers, clinicians and biomedical scientists. In this study, we used an empirically verified model of creep strain accumulation, in a simulation of 10 non-homogeneous samples, which were created from micro-CT scans of human cortical bone of the femur midshaft obtained from a 74-year-old female cadaver. These non-homogeneous samples incorporate the presence of Haversian canals and resorption cavities. The influence of inhomogeneity on the response and variation in the samples in both creep and stress relaxation tests are examined. The relationship between steady-state creep rate, applied loads (stress relaxation and creep tests) and microstructure, that is bone apparent porosity, is obtained. These relations may provide insight into damage accumulation of whole human bones and be relevant to studies on osteoporosis.
authors.affiliation: Department of Mechanical Engineering, Karabuk University, Karabuk 78050, Turkey. ahertas@karabuk.edu.tr
authors.forename: Ahmet H
authors.initials: AH
authors.lastname: Ertas
authors.forename: Keith
authors.initials: K
authors.lastname: Winwood
authors.forename: Peter
authors.initials: P
authors.lastname: Zioupos
authors.forename: John R
authors.initials: JR
authors.lastname: Cotton
mesh_terms: D000368:Aged; D019245:Compressive Strength / Q000502:physiology; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D005260:Female; D005269:Femur / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D017711:Nonlinear Dynamics; D013718:Tensile Strength / Q000502:physiology; D014783:Viscosity; D016474:Weight-Bearing / Q000502:physiology*