title: Identification of four SNPs and association analysis with meat quality traits in the porcine Pitx2c gene.
abstract: The association of the porcine Pitx2c gene with meat quality traits was investigated in the present study. A total of eight single nucleotide polymorphisms (SNPs) were found. Allele frequencies of four SNPs were further detected in four commercial breeds and eight Chinese indigenous breeds. Single SNP and meat quality associations were analyzed in a Yorkshire×Meishan F(2) population. The SNPs c.474C>T (P<0.01) and c.636C>T (P<0.05) showed a significant association with meat color (MCV1). The SNPs c.*37G>A and c.*47G>A were significantly associated with drip loss rate (DLR), water holding capacity (WHC) and meat color value (MCV1) consistently (P<0.05). Linkage disequilibrium (LD) analysis revealed that the adjacent SNPs were in LD. Two major haplotypes were identified, and association analysis between haplotype combinations and meat quality indicated that the presence of two copies of haplotype 1 -CCGG- may improve meat quality.
authors.affiliation: Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, College of Animal Science, Huazhong Agricultural University, Wuhan, 430070, China.
authors.forename: WangJun
authors.initials: W
authors.lastname: Wu
authors.forename: Bo
authors.initials: B
authors.lastname: Zuo
authors.forename: ZhuQing
authors.initials: Z
authors.lastname: Ren
authors.forename: A A R
authors.initials: AA
authors.lastname: Hapsari
authors.forename: MingGang
authors.initials: M
authors.lastname: Lei
authors.forename: DeQuan
authors.initials: D
authors.lastname: Xu
authors.forename: FengE
authors.initials: F
authors.lastname: Li
authors.forename: YuanZhu
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D000483:Alleles; D000818:Animals; D001947:Breeding; D017931:DNA Primers / Q000378:metabolism; D005091:Exons; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D018398:Homeodomain Proteins / Q000235:genetics*; D015810:Linkage Disequilibrium; D008460:Meat; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D013552:Swine; D014157:Transcription Factors / Q000235:genetics*; D000097577:Homeobox Protein PITX2
chemical_list: D017931:DNA Primers; D018398:Homeodomain Proteins; D014157:Transcription Factors; D000097577:Homeobox Protein PITX2