title: Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial.
abstract: OBJECTIVE
  In vitro and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients.
  
  
  METHODS
  A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (n=27), 5 g/d BSP (n=29) or placebo (n=25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment.
  
  
  RESULTS
  In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (n=21), 5 g/d (n=22) and placebo (n=20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (P=0.001 for treatment effect), oxidized low density lipoprotein cholesterol (P=0.03 for treatment effect), OSI (P=0.001 for treatment effect) and significant increase in TAC (P=0.001 for treatment effect). No effects were found on TOS.
  
  
  CONCLUSIONS
  BSP had favorable effects on oxidative stress status in type 2 diabetes patients.
authors.affiliation: Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Bahadoran
authors.forename: P
authors.initials: P
authors.lastname: Mirmiran
authors.forename: F
authors.initials: F
authors.lastname: Hosseinpanah
authors.forename: M
authors.initials: M
authors.lastname: Hedayati
authors.forename: S
authors.initials: S
authors.lastname: Hosseinpour-Niazi
authors.forename: F
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood; D001937:Brassica / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology*; D011208:Powders / Q000494:pharmacology; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008077:Lipoproteins, LDL; D028321:Plant Preparations; D011208:Powders; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde