title: Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite.
abstract: The synthesis of boehmite nanoparticles modified with lanthanides (Eu, Tb and Gd) is described. Their synthesis, characterization and in vitro assays with HeLa cells were performed. The nuclear magnetic relaxation dispersion (NMRD) profiles of the two chelating moieties were studied. Imaging data from laser scanning confocal fluorescence microscopy and flow cytometry revealed that the nanoscaffolds were taken up by the cells, distributed throughout the cytoplasm and showed no toxicity. This platform could represent an alternative to silica-based inert matrices as imaging vehicles.
authors.affiliation: Instituto de Ciencia Molecular (ICMol), Departamento de Química Inorgánica, Universidad de Valencia, Edificio de Institutos de Paterna, C/Catedrático José Beltrán 2, Apartado de Correos 22085, 46071, Valencia, Spain.
authors.forename: Estefanía
authors.initials: E
authors.lastname: Delgado-Pinar
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Albelda
authors.forename: Juan C
authors.initials: JC
authors.lastname: Frías
authors.forename: Olga
authors.initials: O
authors.lastname: Barreiro
authors.forename: Emilio
authors.initials: E
authors.lastname: Tejera
authors.forename: Vojtěch
authors.initials: V
authors.lastname: Kubíček
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Jiménez-Borreguero
authors.forename: Francisco
authors.initials: F
authors.lastname: Sánchez-Madrid
authors.forename: Eva
authors.initials: E
authors.lastname: Tóth
authors.forename: Javier
authors.initials: J
authors.lastname: Alarcón
authors.forename: Enrique
authors.initials: E
authors.lastname: García-España
mesh_terms: D000536:Aluminum Hydroxide / Q000737:chemistry*; D000537:Aluminum Oxide / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D005434:Flow Cytometry; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D018613:Microscopy, Confocal; D010316:Particle Size
chemical_list: D056831:Coordination Complexes; D005456:Fluorescent Dyes; D028581:Lanthanoid Series Elements; D000536:Aluminum Hydroxide; C069471:aluminum oxide hydroxide; D000537:Aluminum Oxide