title: Changing pattern of antibiotic susceptibility in intensive care units: ten years experience of a university hospital.
abstract: The study was performed to assess microorganisms and antibiotic susceptibility patterns during ten years in intensive care units of a University Hospital. Infection Control Committee has active, prospective surveillance in ICUs for thirteen years. Ten years data of ICUs was evaluated retrospectively from surveillance forms. Microorganisms and their antibiotic resistance were recorded according to the years. During ten years, gram negative microorganisms were the most frequent isolated microorganisms from clinical specimens. Acinetobacter baumannii (21.8%), Pseudomonas aerigunosa (16%), Escherichia coli (10.4%) and Klebsiella pneumoniae (8%) were the most common gram negative microorganisms. However, Staphylococcus aureus was the most prevalent gram positive microorganism, the incidence decreased from 18.6% to 4.8% during ten years. Also antibiotic susceptibility of microorganisms changed during ten years. Carbapenem resistance increased from 44% to 92% in A. baumannii and ciprofloxacin resistance increased in E. coli from 28% to 60% and in K. pneumoniae from 21% to 55% during ten years. However, methicilin resistance decreased in S. aureus from 96% to 54%. In conclusion, antibiotic resistance is growing problem in ICUs. Rationale antibiotic policies and infection control measures will prevent the development of resistance.
authors.affiliation: Erciyes University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Kayseri, Turkey. ealp@erciyes.edu.tr
authors.forename: Emine
authors.initials: E
authors.lastname: Alp
authors.forename: Bilge
authors.initials: B
authors.lastname: Kiran
authors.forename: Dilek
authors.initials: D
authors.lastname: Altun
authors.forename: Gamze
authors.initials: G
authors.lastname: Kalin
authors.forename: Ramazan
authors.initials: R
authors.lastname: Coskun
authors.forename: Murat
authors.initials: M
authors.lastname: Sungur
authors.forename: Aynur
authors.initials: A
authors.lastname: Akin
authors.forename: Duygu
authors.initials: D
authors.lastname: Percin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Doganay
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000453:epidemiology / Q000382:microbiology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents