title: Effect of homocysteine on properties of neutrophils activated in vivo.
abstract: We have found that neutrophils begin to express NMDA receptors on their membranes after in vivo activation. These receptors are the target for action of homocysteine (HC). After incubation of activated neutrophils with HC, the degranulation process is stimulated and generation of reactive oxygen species is increased. We conclude that expression of NMDA receptors on neutrophil membrane makes neutrophils sensitive to HC. Thus, hyperhomocysteinemia may induce additional stimulation of immune competent cells.
authors.affiliation: Biological Faculty, Lomonosov Moscow State University, Russia. kate-msu2008@yandex.ru
authors.forename: E A
authors.initials: EA
authors.lastname: Bryushkova
authors.forename: E A
authors.initials: EA
authors.lastname: Vladychenskaya
authors.forename: M S
authors.initials: MS
authors.lastname: Stepanova
authors.forename: A A
authors.initials: AA
authors.lastname: Boldyrev
mesh_terms: D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology; D006710:Homocysteine / Q000378:metabolism / Q000494:pharmacology*; D016202:N-Methylaspartate / Q000494:pharmacology; D018375:Neutrophil Activation / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D016194:Receptors, N-Methyl-D-Aspartate; D006710:Homocysteine; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate