title: Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas.
abstract: Local recurrence of glioblastomas is a major cause of patient mortality after definitive treatment. This review discusses the roles of the chemokine stromal cell-derived factor-1 and its receptor CXC chemokine receptor 4 (CXCR4) in affecting the sensitivity of glioblastomas to irradiation. Blocking these molecules prevents or delays tumour recurrence after irradiation by inhibiting the recruitment of CD11b+ monocytes/macrophages that participate in revascularising the tumour. We review the literature pertaining to the mechanism by which revascularisation occurs following tumour irradiation using experimental models. Areas of interest and debate in the literature include the process by which endothelial cells die after irradiation and the identity/origin of the cells that reconstitute the tumour blood vessels after injury. Understanding the processes that mediate tumour revascularisation will guide the improvement of clinical strategies for preventing recurrence of glioblastoma after irradiation.
authors.affiliation: Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, 269 Campus Drive West, CCSR Room 1255, Stanford, CA 94305, USA.
authors.forename: D
authors.initials: D
authors.lastname: Tseng
authors.forename: D A
authors.initials: DA
authors.lastname: Vasquez-Medrano
authors.forename: J M
authors.initials: JM
authors.lastname: Brown
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply / Q000532:radiotherapy*; D039481:CD11b Antigen / Q000032:analysis; D054377:Chemokine CXCL12 / Q000037:antagonists & inhibitors* / Q000502:physiology; D005909:Glioblastoma / Q000098:blood supply / Q000532:radiotherapy*; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: D039481:CD11b Antigen; D054377:Chemokine CXCL12; D019718:Receptors, CXCR4