title: Her2 Neu overexpression counteracts the growth effects of C-myc in breast-cancer cells.
abstract: Amplification and overexpression of the c-myc gene and/or the HER2/neu gene are common events in many human breast cancers. Studying the effects of increasing c-myc expression in breast cancer cell lines, we found that the anchorage-dependent growth rate of cells overexpressing HER2/neu is not affected by increased c-myc expression, whereas enhanced expression of c-myc in cells that do not overexpress HER2/neu can slow that growth rate. Increased c-myc expression did not affect anchorage-independent growth in soft agarose in any of the cells, and it slowed the anchorage-dependent growth of only those cells that do not overexpress HER2/neu, suggesting that HER2/neu overexpression may counteract the anchorage-dependent growth inhibition mediated by c-myc.
authors.affiliation: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT TUMOR BIOL,BOX 79,1515 HOLCOMBE BLVD,HOUSTON,TX 77030.
authors.forename: S
authors.initials: S
authors.lastname: Miller
authors.forename: M
authors.initials: M
authors.lastname: Hung