title: Combination therapy of single or fractionated x-rays and schizophyllan (spg) for murine B-16 melanoma.
abstract: B-16 melanoma transplanted into C57BL/6 mice was used to investigate the antitumor effect of Schizophyllan (SPG) combination with local irradiation by X-rays using 4 fractions of 3 Gy or 9 Gy and single fractions of 12, 19 and 26 Gy. In the groups which received a single fraction of 26 Gy and 4 fractions of 9 Gy, significant differences were found between the groups with/without SPG in terms of tumor volume change and lymph node and pulmonary metastases. In terms of survival, significant difference was found only in the 4 fraction of the 9 Gy group. SPG had no antitumor effect nor life-prolonging effect, when it was applied to tumors irradiated with single fractions of 12 and 19 Gy or 4 fractions of 3 Gy, except for some metastasis-suppressing effect in the group given 19 Gy. It seems that SPG has some adjuvant effect only where a limited number of tumor cells remain following rather large dose of X-irradiation. Furthermore, the gain produced by host-mediated immune response augmented by SPG seems to be larger in the 4 fraction group. Therefore, combination radiotherapy using SPG may be advantageous for patients with complete response or a good response after multifractionated irradiation.
authors.affiliation: UNIV BRITISH COLUMBIA,TRIUMF,VANCOUVER V6T 2A3,BC,CANADA. BRITISH COLUMBIA CANC AGCY,DEV RADIOTHERAPY,VANCOUVER V5Z 4E6,BC,CANADA. BRITISH COLUMBIA CANC RES CTR,VANCOUVER V5Z 4E6,BC,CANADA. XENOVA LTD,SLOUGH SL1 4EQ,BERKS,ENGLAND. BRITISH COLUMBIA CANC AGCY,DIV PHYS,VANCOUVER V5Z 4E6,BC,CANADA.
authors.forename: Y
authors.initials: Y
authors.lastname: Takai
authors.forename: G
authors.initials: G
authors.lastname: Goodman
authors.forename: D
authors.initials: D
authors.lastname: Chaplin
authors.forename: W
authors.initials: W
authors.lastname: Grulkey
authors.forename: G
authors.initials: G
authors.lastname: Lam