title: Incremental diagnostic value and impact on patient management of somatostatin receptor scintigraphy with indium-111-pentetreotide in gastroenteropancreatic neuroendocrine tumors.
abstract: OBJECTIVE
  To evaluate the efficacy of somatostatin analog scintigraphy with indium-111-pentetreotide and its overall impact on management in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET).
  
  
  METHODS
  Twenty-two consecutive patients with a proven or clinically suspected GEP-NET with or without proven metastases were imaged at 24 and 48 h after injection of (111)In-pentetreotide. The scintigraphic findings were compared with results from conventional imaging methods. The final diagnosis was based on histopathological and surgical findings and complementary radiology.
  
  
  RESULTS
  Somatostatin receptor-positive lesions were found in 20 of the patients, whereas conventional methods were positive in 18 patients. Additionally, 13 new tumor sites were discovered by somatostatin receptor scintigraphy in 5 patients (liver: 6; chest: 2; bone: 1; abdomen: 4). The surgical therapeutic strategy was changed in 7 patients (32%).
  
  
  CONCLUSIONS
  Our data reinforced that scintigraphy with (111)In-pentetreotide represents the imaging modality of choice in the initial evaluation of GEP-NET. It is highly accurate and can identify clinically unsuspected lesions and optimize the overall staging. It also guides optimal therapy choice and most importantly identifies patients with inoperable or metastatic disease who might be candidates for high-dose targeted therapy.
authors.affiliation: Department of Nuclear Medicine, Hussain Makki Al Jumma Center for Specialized Surgery, Ministry of Health, Khaitan, Kuwait. dr_shajji@yahoo.com
authors.forename: Sharjeel
authors.initials: S
authors.lastname: Usmani
authors.forename: Haider Ali
authors.initials: HA
authors.lastname: Khan
authors.forename: Maha
authors.initials: M
authors.lastname: Abdulla
authors.forename: Najeeb
authors.initials: N
authors.lastname: Ahmed
authors.forename: Fawaz
authors.initials: F
authors.lastname: abu Huda
authors.forename: Fahad
authors.initials: F
authors.lastname: Marafi
authors.forename: Farida
authors.initials: F
authors.lastname: al Kandari
authors.forename: Shihab
authors.initials: S
authors.lastname: al Mohannadi
authors.forename: Naheel
authors.initials: N
authors.lastname: al Nafisi
mesh_terms: D000328:Adult; D000368:Aged; D018931:Antineoplastic Agents, Hormonal; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D015282:Octreotide / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011877:Radionuclide Imaging / Q000295:instrumentation* / Q000379:methods; D017481:Receptors, Somatostatin; D013004:Somatostatin / Q000031:analogs & derivatives*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D018931:Antineoplastic Agents, Hormonal; D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; D013004:Somatostatin; C081788:pentetreotide; D015282:Octreotide