title: Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease.
abstract: BACKGROUND
  Glucagon-like peptide-1 (GLP-1) is an incretin hormone which has been shown to promote myocardial glucose uptake. Its pharmacological properties as a cardioprotective agent are attractive because it has a short half-life and there is minimal risk of hypoglycaemia.
  
  
  OBJECTIVE
  To assess the hypothesis that intravenous infusion of GLP-1 would protect the heart from ischaemic left ventricular (LV) dysfunction during dobutamine stress echocardiography (DSE) in patients with coronary artery disease (CAD).
  
  
  METHODS
  Randomised crossover study.
  
  
  METHODS
  14 patients with CAD and good LV function awaiting revascularisation underwent two DSE scans in a randomised order. GLP-1 was infused intravenously at 1.2 pmol/kg/min starting 30 min before the DSE for one of the scans and the other scan acted as a control.
  
  
  METHODS
  Global and regional wall LV function assessed using tissue Doppler imaging at rest, peak stress and 30 min into recovery.
  
  
  RESULTS
  Global LV function was greater at peak stress during GLP-1 infusion compared with control (ejection fraction 77.0±4.4 vs 70.8±5.0%, p<0.0001; mitral annular systolic velocity 12.18±3.10 vs 11.31±3.11 cm/s, p=0.0004). GLP-1 infusion improved regional wall LV function in 12 non-apical segments assessed by velocity, strain and strain rate. This beneficial effect was predominantly seen in ischaemic segments. In recovery, infusion of GLP-1 mitigated the post-ischaemic stunning seen in the control scan.
  
  
  CONCLUSIONS
  Intravenous infusion of GLP-1 protects the heart from ischaemic LV dysfunction induced by dobutamine stress in patients with CAD.
  
  
  BACKGROUND
  URL: http://isrctn.org.
  
  
  BACKGROUND
  ISRCTN 69686930.
authors.affiliation: Department of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Read
authors.forename: Fakhar Z
authors.initials: FZ
authors.lastname: Khan
authors.forename: David P
authors.initials: DP
authors.lastname: Dutka
mesh_terms: D002316:Cardiotonic Agents / Q000009:adverse effects; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003326:Coronary Circulation / Q000187:drug effects*; D018592:Cross-Over Studies; D004280:Dobutamine / Q000009:adverse effects*; D025401:Echocardiography, Stress / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D052216:Glucagon-Like Peptide 1 / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine; D052216:Glucagon-Like Peptide 1