title: Csf 5 - hiaa in violent and non-violent suicide attempters.
abstract: Many studies have reported involvement of monoamine neurotransmission in suicide through measurement of serotonin and its main metabolite, 5-HIAA, in brain of suicide victims and in CSF of suicide attempters. 23 non-depressed non-psychotic suicide attempters and equal number of controls were selected, and all the subjects were screened on Cornell Medical Index. Suicide attempters were assessed on Risk-Rescue Rating Scale and were divided into non-violent suicide attempters (N= 12) and violent suicide attempters (N= II). CSF of all subjects was collected by lumbar puncture and CSF 5-HIAA was measured by high performance liquid chromatography with electro-chemical detector. Risk-rescue rating score was significantly higher in violent suicide attempters as compared to non-violent suicide attempters. Mean CSF- 5- HIAA was significantly lower in suicide attempters as compared to normal controls. Mean CSF 5-HIAA was significantly lower in violent suicide attempters as compared to non-violent suicide attempters.
authors.affiliation: J.K. TRIVEDI, M.D., Associate Professor, Department of Psychiatry, K.G's Medical College, Lucknow.
authors.forename: J K
authors.initials: JK
authors.lastname: Trivedi
authors.forename: S
authors.initials: S
authors.lastname: Pandey
authors.forename: P K
authors.initials: PK
authors.lastname: Dalal
authors.forename: M P
authors.initials: MP
authors.lastname: Dubey
authors.forename: P K
authors.initials: PK
authors.lastname: Sinha