title: Alveolar rhabdomyosarcoma - primary and recurrent metastatic tumor has chromosomal translocation t(2-13)(q37-q14), amplified N-myc and is tumorigenic in nude-mice.
abstract: Tissue specimens of primary and recurrent metastatic alveolar rhabdomyosarcoma (A-RMS) from a 12 year old child were cultured and shown to contain A-RMS specific t(2;13) (q37;q14) chromosomal translocation and to be tumourigenic in nude mice. Whereas c-myc protooncogene was neither amplified nor grossly rearranged, both biopsy samples were demonstrated to have 5-fold amplification of N-myc gene sequence. N-myc gene was also amplified in cell cultures produced by primary and metastatic tumour biopsies. Such a model for A-RMS has not been previously available.
authors.affiliation: MANCHESTER POLYTECH,MANCHESTER M1 5GD,LANCS,ENGLAND.
authors.forename: P
authors.initials: P
authors.lastname: Dias
authors.forename: P
authors.initials: P
authors.lastname: Kumar
authors.forename: H
authors.initials: H
authors.lastname: Marsden
authors.forename: H
authors.initials: H
authors.lastname: Gattamaneni
authors.forename: J
authors.initials: J
authors.lastname: Heighway
authors.forename: S
authors.initials: S
authors.lastname: Kumar