title: Epidermal growth-factor and transforming growth factor-alpha in human meningiomas.
abstract: Recently we have shown that human meningiomas overexpress epidermal growth factor receptor (EGFR) (Torp SH et al APMIS 100: 797-802, 1992). We therefore wanted to examine these tumours for the expression of the EGFR ligands epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha). Normal human meningeal tissues were used as controls. Immunohistochemistry (IH) and radioimmunoassay (RIA) demonstrated the presence of EGF and/or TGF-alpha. immunoreactivity in sixteen of nineteen meningiomas. By means of RIA detectable amount of TGF-alpha was also recorded in normal leptomeninges. Discrepancies between IH and RIA were noted and are discussed. Our findings suggest that EGFR/EGF/TGF-alpha play a role in growth regulatory mechanisms in human meningiomas.
authors.affiliation: UNIV HOSP TRONDHEIM,DEPT NEUROSURG,N-7006 TRONDHEIM,NORWAY. UNIV HOSP TRONDHEIM,N-7006 TRONDHEIM,NORWAY.
authors.forename: S
authors.initials: S
authors.lastname: Torp
authors.forename: G
authors.initials: G
authors.lastname: Unsgaard
authors.forename: A
authors.initials: A
authors.lastname: Dalen