title: Parsing p53 Transactivation.
abstract: Two functions of p53 are undisputed. Biologically, p53 is a potent tumor suppressor, whereas biochemically, it is a robust transcriptional activator of numerous target genes. Are these biological and biochemical functions of p53 related? The surprising answer, recently reported by Brady et al. (2011) in Cell, is minimally.
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. jcampisi@buckinstitute.org
authors.forename: Judith
authors.initials: J
authors.lastname: Campisi