title: Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes.
abstract: METHODS
  Chromium is an essential nutrient involved in normal carbohydrate and lipid metabolism. It influences glucose metabolism by potentiating the action as taking part in insulin signal amplification mechanism. A placebo-controlled single blind, prospective study was carried out to investigate the effect of chromium supplementation on blood glucose, HbA(1)C and lipid profile in newly onset patients with type-2 diabetes.
  
  
  METHODS
  Total 40 newly onset type-2 diabetics were selected and after 1 month stabilization further randomly divided into two groups viz. study group and placebo group. The study group received 9 g brewer's yeast (42 μg Cr) daily and the other placebo group received yeast devoid of chromium for 3 months. Subjects were instructed not to change their normal eating and living habits. Fasting blood glucose, HbA(1)C and lipid profile were analyzed at beginning and completion of the study.
  
  
  RESULTS
  Results revealed that fasting blood glucose level significantly reduced in the subjects consuming yeast supplemented with chromium (197.65±6.68 to 103.68±6.64 mg/dL; p<0.001). HbA(1)C values improved significantly from 9.51±0.26% to 6.86±0.28%; p<0.001 indicating better glycaemic control. In experimental group total cholesterol, TG and LDL levels were also significantly reduced from 199.66±3.11 to 189.26±3.01 mg/dL; p<0.02, 144.94±8.31 to 126.01±8.26; p<0.05 and 119.19±1.71 to 99.58±1.10; p<0.001 respectively.
  
  
  CONCLUSIONS
  These data demonstrate beneficial effect of chromium supplementation on glycaemic control and lipid variables in subjects with newly onset type-2 diabetes.
authors.affiliation: College of Home Science, MPUA&T, Udaipur, Rajasthan, India.
authors.forename: Shilpi
authors.initials: S
authors.lastname: Sharma
authors.forename: Rajendra Prasad
authors.initials: RP
authors.lastname: Agrawal
authors.forename: Maya
authors.initials: M
authors.lastname: Choudhary
authors.forename: Shreyans
authors.initials: S
authors.lastname: Jain
authors.forename: Shekhar
authors.initials: S
authors.lastname: Goyal
authors.forename: Vivek
authors.initials: V
authors.lastname: Agarwal
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects*; D016022:Case-Control Studies; D002857:Chromium / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D019587:Dietary Supplements; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D002857:Chromium; D006442:Glycated Hemoglobin; D008055:Lipids