title: Radon lung dosimetry models.
abstract: Two different modelling approaches are currently used to calculate short-lived radon progeny doses to the lungs: the semi-empirical compartment model proposed by the International Commission on Radiological Protection and deterministic and stochastic airway generation models. The stochastic generation model IDEAL-DOSE simulates lung morphometry, transport, deposition and clearance of inhaled radionuclides, and cellular dosimetry by Monte Carlo methods. Specific dosimetric issues addressed in this paper are: (1) distributions of bronchial doses among and within bronchial airway generations; (2) relative contributions of radon progeny directly deposited in a given airway generation and those passing through from downstream generations to the bronchial dose in that generation; (3) distribution of bronchial doses among the five lobes of the human lung; (4) inhomogeneity of surface activities and resulting doses within bronchial airway bifurcations; (5) comparison of bronchial doses between non-smokers and smokers; (6) relative contributions of sensitive target cells in bronchial epithelium to lung cancer induction and (7) intra- and intersubject variations of bronchial doses.
authors.affiliation: Division of Physics and Biophysics, Department of Materials Research and Physics, University of Salzburg, Hellbrunnerstrasse 34, A-5020 Salzburg, Austria. Werner.Hofmann@sbg.ac.at
authors.forename: W
authors.initials: W
authors.lastname: Hofmann
authors.forename: R
authors.initials: R
authors.lastname: Winkler-Heil
mesh_terms: D000328:Adult; D001980:Bronchi / Q000378:metabolism; D003198:Computer Simulation; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D011829:Radiation Dosage; D011874:Radiometry; D011886:Radon / Q000032:analysis* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D011886:Radon