title: A case of Crimean-Congo haemorrhagic fever successfully treated with therapeutic plasma exchange and ribavirin.
abstract: Crimean-Congo haemorrhagic fever (CCHF) has become an important problem in certain parts of the world. Cytokine storm plays a critical role in the pathogenesis of CCHF. Early diagnosis, supportive therapy and invasive monitoring are the cornerstones of the management of CCHF. Ribavirin is active against CCHF virus in vitro, however, evidence of clinical efficacy is still conflicting. Here, we describe a patient successfully recovered from CCHF with a combination of plasma exchange and ribavirin therapy.
authors.affiliation: Department of Hematology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Kurnaz
authors.forename: Gokhan
authors.initials: G
authors.lastname: Metan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Coskun
authors.forename: Leylagul
authors.initials: L
authors.lastname: Kaynar
authors.forename: Bulent
authors.initials: B
authors.lastname: Eser
authors.forename: Mehmet
authors.initials: M
authors.lastname: Doganay
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000187:drug effects*; D006479:Hemorrhagic Fever, Crimean / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy* / Q000821:virology; D006801:Humans; D010951:Plasma Exchange / Q000706:statistics & numerical data; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D012254:Ribavirin