title: Biospecimen reporting for improved study quality (BRISQ).
abstract: Human biospecimens are subject to a number of different collection, processing, and storage factors that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research utilizing human tissues, it is critical that information regarding the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality (BRISQ) recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The BRISQ guidelines are proposed as an important and timely resource tool to strengthen communication and publications around biospecimen-related research and help reassure patient contributors and the advocacy community that the contributions are valued and respected.
authors.affiliation: Office of Biorepositories and Biospecimen Research, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Moore
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Kelly
authors.forename: Scott D
authors.initials: SD
authors.lastname: Jewell
authors.forename: Lisa M
authors.initials: LM
authors.lastname: McShane
authors.forename: Douglas P
authors.initials: DP
authors.lastname: Clark
authors.forename: Renata
authors.initials: R
authors.lastname: Greenspan
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Hayes
authors.forename: Pierre
authors.initials: P
authors.lastname: Hainaut
authors.forename: Paula
authors.initials: P
authors.lastname: Kim
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Mansfield
authors.forename: Olga
authors.initials: O
authors.lastname: Potapova
authors.forename: Peter
authors.initials: P
authors.lastname: Riegman
authors.forename: Yaffa
authors.initials: Y
authors.lastname: Rubinstein
authors.forename: Edward
authors.initials: E
authors.lastname: Seijo
authors.forename: Stella
authors.initials: S
authors.lastname: Somiari
authors.forename: Peter
authors.initials: P
authors.lastname: Watson
authors.forename: Heinz-Ulrich
authors.initials: HU
authors.lastname: Weier
authors.forename: Claire
authors.initials: C
authors.lastname: Zhu
authors.forename: Jim
authors.initials: J
authors.lastname: Vaught
mesh_terms: D006801:Humans; D011786:Quality Control; D012106:Research / Q000592:standards*; D013048:Specimen Handling