title: Nakijinamines C-E, new heteroaromatic alkaloids from the sponge Suberites species.
abstract: Three new heteroaromatic alkaloids, nakijinamines C-E (1-3), which are a hybrid of the aaptamine-type and bromoindole alkaloids possessing a taurine- or histidine-derived residue, have been isolated from an Okinawan marine sponge Suberites species. The structures of 1-3 were elucidated on the basis of spectroscopic data and chemical conversions. Nakijinamines C (1) and E (3) are the first natural products possessing a 1H-oxazolo[4',5':4,5]benzo[1,2,3-de][1,6]naphthyridine ring system.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Azusa
authors.initials: A
authors.lastname: Shibazaki
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.forename: Jane
authors.initials: J
authors.lastname: Fromont
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D001234:Aspergillus niger / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification*; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D007941:Leukemia P388; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D047233:Suberites / Q000737:chemistry*
chemical_list: D006842:Hydrocarbons, Brominated; D026121:Indole Alkaloids; C560836:nakijinamine C; C560837:nakijinamine D; C560838:nakijinamine E