title: Another cause of pancytopenia in a patient receiving temozolomide.
abstract: OBJECTIVE
  To report pancytopenia caused by temozolomide, a second-generation alkylating agent.
  
  
  METHODS
  A 22-year-old patient presenting with seizures and confusion was seen in the emergency room. Cranial magnetic resonance imaging revealed a mass. After surgery, the patient was diagnosed with glioblastoma multiforme and was given temozolomide at 150 mg/m(2) on days 1 through 5 every 4 weeks. During the last cycle of temozolomide, grade 3 thrombocytopenia persisted. Possible causes of pancytopenia including vitamin B(12) deficiency were investigated.
  
  
  CONCLUSIONS
  This case report shows that vitamin B(12) deficiency can be a potential cause of pancytopenia and it should be kept in mind for patients receiving chemotherapy.
authors.affiliation: Department of Internal Medicine, School of Medicine, Gaziantep University, Sahinbey Medical Center, Gaziantep, Turkey. drpehlivan@hotmail.com
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Pehlivan
authors.forename: Alper
authors.initials: A
authors.lastname: Sevinc
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Turkbeyler
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dirier
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Kalender
authors.forename: Celalettin
authors.initials: C
authors.lastname: Camci
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D003606:Dacarbazine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D005909:Glioblastoma; D006801:Humans; D010198:Pancytopenia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D012307:Risk Factors; D000077204:Temozolomide; D014806:Vitamin B 12 Deficiency / Q000150:complications*; D055815:Young Adult
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide