title: Transition metal catalyzed manipulation of non-polar carbon-hydrogen bonds for synthetic purpose.
abstract: The direct addition of ortho C-H bonds in various aromatic compounds such as ketones, esters, imines, imidates, nitriles, and aldehydes to olefins and acetylenes can be achieved with the aid of transition metal catalysts. The ruthenium catalyzed reaction is usually highly efficient and useful as a general synthetic method. The coordination to the metal center by a heteroatom in a directing group such as carbonyl and imino groups in aromatic compounds is the key step in this process. Mechanistically, the reductive elimination to form a C-C bond is the rate-determining step, while the C-H bond cleavage step is not. (Communicated by Ryoji NoyorI, M.J.A.).
authors.affiliation: Nara Institute of Science and Technology, Takayama, Ikoma, Nara, Japan. murai@ad.naist.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Murai
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006860:Hydrogen Bonding; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D009930:Organic Chemicals; D028561:Transition Elements; D002244:Carbon