title: [Experience using doxorubicin-loaded DC Beads® during hepatic chemoembolisation].
abstract: BACKGROUND
  Hepatocellular carcinoma is the most common and aggressive liver and biliary tumour. Hepatic chemoembolisation with doxorubicin-loaded DC Beads(®) is a local therapy for patients with localised nodes, which are not suitable for surgery. The objective of this study is to describe the clinical situations in which this procedure has been used and its early toxicity.
  
  
  METHODS
  Retrospective descriptive study of patients treated with doxorubicin-loaded DC Beads(®) undergoing hepatic chemoembolisation from October 2006 until July 2009. Data were taken from the Farhos Oncología(®) programme and clinical histories.
  
  
  RESULTS
  Twenty-two patients were treated during the study period, 15 men and 6 women, with an average age of 66 years. This technique was used for patients diagnosed with unresectable liver cancer. Out of the patient total, 6 were on the liver transplant waiting list. Patients were assessed using the Child-Pugh score: 15 patients in group A, 5 in group B and 1 in group C; and according to Okuda staging system: 14 were in group I, 6 in group II and 1 in group III. The most common toxicity was post-chemoembolisation in 16 patients, which were treated with symptomatic medication.
  
  
  CONCLUSIONS
  Using doxorubicin-loaded microspherical DC Beads(®) during transarterial chemoembolisation has been adapted to uses with scientific evidence and tolerated by all patients. Incidences during administration were mild and were resolved with symptomatic medication.
authors.affiliation: Servicio de Farmacia, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: M
authors.initials: M
authors.lastname: Muros-Ortega
authors.forename: M S
authors.initials: MS
authors.lastname: Díaz-Carrasco
authors.forename: N
authors.initials: N
authors.lastname: Vila-Clérigues
authors.forename: F
authors.initials: F
authors.lastname: Mendoza-Otero
authors.forename: A
authors.initials: A
authors.lastname: de la Rubia
authors.forename: A
authors.initials: A
authors.lastname: Capel Alemán
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000601:surgery / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010166:Palliative Care; D011300:Preoperative Care; D012189:Retrospective Studies; D014661:Vasoconstriction / Q000187:drug effects; D014850:Waiting Lists
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin