title: The usefulness of cytogenetic findings in differential-diagnosis of metastases of unknown origin.
abstract: Chromosomal abnormalities can be applied in the diagnosis and classification of some metastases of unknown origin. A selective search is most appropriate for treatable tumors, such as prostate, ovary, breast, small-cell lung cancer and germ cell tumors. Cytogenetic analysis may be particularly useful in these cases, since some of these tumors have been found to have specific chromosomal changes that are generally retained in the metastases. We discuss the usefulness of cytogenetic analysis in differentiating the origin of metastases and review the few cases reported in the literature.
authors.affiliation: CANC CTR SW,BIOMED RES INST,6401 E THOMAS RD,SCOTTSDALE,AZ 85251.
authors.forename: Y
authors.initials: Y
authors.lastname: Ozisik
authors.forename: A
authors.initials: A
authors.lastname: Meloni
authors.forename: A
authors.initials: A
authors.lastname: Sandberg