title: Macrolactin W, a new antibacterial macrolide from a marine Bacillus sp.
abstract: Bioactivity-guided isolation for the new/novel metabolites from the EtOAc extract obtained from the culture broth of a marine Bacillus sp. 09ID194 followed by chromatographic fractionations and subsequently HPLC purifications led to the isolation of two known macrolides, macrolactins A (1) and Q (2), together with a new glycosylated marcrolide, macrolactin W (3). The chemical structures of compounds 1-3 were assigned based on extensive MS and NMR spectral data analysis and literature review. Compound 3 showed potent antibacterial activity against both Gram-positive and Gram-negative pathogenic bacteria.
authors.affiliation: Marine Natural Products Chemistry Laboratory, Korea Ocean Research & Development Institute, Ansan, Seoul, Republic of Korea.
authors.forename: M A Mojid
authors.initials: MA
authors.lastname: Mondol
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Shin
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001407:Bacillus / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D056910:Republic of Korea
chemical_list: D000900:Anti-Bacterial Agents; D006027:Glycosides; D018942:Macrolides; C562359:macrolactin W