title: The biokinetics of ruthenium in the human body.
abstract: The International Commission on Radiological Protection (ICRP) is updating its biokinetic and dosimetric models for workers and subsequently will revisit its models for members of the public. This paper summarises the biokinetic database for ruthenium and proposes a new biokinetic model for systemic ruthenium. In contrast to the ICRP's current model, the proposed model depicts recycling of ruthenium between tissues and blood and a non-uniform distribution of systemic ruthenium. The paper also points out inconsistencies between the ICRP's respiratory model for RuO(4) vapour and reported data, and inconsistencies between the ICRP's default gastrointestinal (GI) uptake value and data for some forms of ruthenium. Dosimetric implications of the proposed systemic model and the findings for inhaled RuO(4) vapour and GI uptake of ruthenium are examined.
authors.affiliation: Oak Ridge National Laboratory, Building 545TPK, MS6495, Oak Ridge, TN 37831, USA. rwl@ornl.gov
authors.forename: R W
authors.initials: RW
authors.lastname: Leggett
mesh_terms: D000042:Absorption; D000818:Animals; D041981:Gastrointestinal Tract / Q000528:radiation effects; D006801:Humans; D007700:Kinetics; D016273:Occupational Exposure; D011874:Radiometry / Q000379:methods*; D012015:Reference Standards; D012137:Respiratory System / Q000528:radiation effects; D017975:Ruthenium Compounds / Q000737:chemistry; D012429:Ruthenium Radioisotopes / Q000032:analysis / Q000493:pharmacokinetics*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D017975:Ruthenium Compounds; D012429:Ruthenium Radioisotopes; C027646:ruthenium tetraoxide