title: The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese.
abstract: OBJECTIVE
  The SLC2A9 gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion. The single nucleotide polymorphisms (SNPs) of SLC2A9 accounted for 5% variance of serum uric acid (UA). UA was identified as a risk factor for type 2 diabetes mellitus (DM). We investigated whether the SLC2A9 gene variations are associated with type 2 DM in Han Chinese.
  
  
  METHODS
  Three common SNPs of the SLC2A9, rs1014290, rs2280205, and rs3733591, were genotyped in 1003 Han Chinese randomly selected from Kaohsiung, Taiwan.
  
  
  RESULTS
  The variant SNP rs1014290 is associated with decreased 0.12-fold risk of type 2 DM (P = .002). Per-copy increase in the minor C-allele results in 0.13 mmol/L (P = .037) and 10.03 μmol/L (P = .016) decrease in serum glucose and UA, respectively.
  
  
  CONCLUSIONS
  The SNP rs1014290 within the SLC2A9 gene is associated with type 2 DM in Han Chinese.
authors.affiliation: Department of Internal Medicine, Kaohsiung Municipal Hsiaokang Hospital, Kaohsiung, Taiwan.
authors.forename: Wan-Chun
authors.initials: WC
authors.lastname: Liu
authors.forename: Chi-Chih
authors.initials: CC
authors.lastname: Hung
authors.forename: Szu-Chia
authors.initials: SC
authors.lastname: Chen
authors.forename: Ming-Yen
authors.initials: MY
authors.lastname: Lin
authors.forename: Ling-I
authors.initials: LI
authors.lastname: Chen
authors.forename: Daw-Yang
authors.initials: DY
authors.lastname: Hwang
authors.forename: Jer-Ming
authors.initials: JM
authors.lastname: Chang
authors.forename: Jer-Chia
authors.initials: JC
authors.lastname: Tsai
authors.forename: Hung-Chun
authors.initials: HC
authors.lastname: Chen
authors.forename: Shang-Jyh
authors.initials: SJ
authors.lastname: Hwang
mesh_terms: D044466:Asian People / Q000235:genetics*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D051246:Glucose Transport Proteins, Facilitative; C411811:SLC2A9 protein, human