title: [Intrahepatic cholestasis in chronic liver diseases].
abstract: The syndrome of cholestasis is a common manifestation of chronic liver disease (CLD) of any etiology: alcoholic, viral, drug, metabolic, etc. The basis of the formation of cholestasis is a violation of the synthesis, secretion or bile outflow. Accession intrahepatic cholestasis (field surgery) for chronic liver disease alters its course, aggravates the condition of the patient, reduces the immune system, leads to development of severe septic complications, significantly reduces the quality of life (QoL) and worsens the prognosis. In published data, as well as the results of original research aimed at improving the diagnosis and treatment of syndrome of field surgery. Was given the definition of the severity of field surgery, defined the criteria for severity, identified the severity of field surgery. Clarified the influence of field surgery in the state of the plasma level of coagulation, as well as the phosphorus-calcium metabolism in CLD of various etiologies. The advantages and versatility combined antiholestaticheskoy field surgery therapy for moderate and severe degree of different etiologies. An algorithm for treatment of field surgery, suggesting a differential approach to therapy depending on the severity of field surgery.
authors.forename: E V
authors.initials: EV
authors.lastname: Golovanova
authors.forename: A V
authors.initials: AV
authors.lastname: Petrakov
authors.forename: K K
authors.initials: KK
authors.lastname: Noskova
mesh_terms: D001777:Blood Coagulation; D002780:Cholestasis, Intrahepatic / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D008111:Liver Function Tests; D011379:Prognosis; D011788:Quality of Life; D012436:S-Adenosylmethionine / Q000008:administration & dosage / Q000627:therapeutic use; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014580:Ursodeoxycholic Acid; D012436:S-Adenosylmethionine