title: Clinical and immunological effects of a synthetic Beta-human chorionic-gonadotropin vaccine.
abstract: We treated 23 patients with non-trophoblastic cancers with escalating doses of a synthetic vaccine consisting of the carboxy-terminal peptide of beta human chorionic gonadotropin conjugated to diphtheria toroid (CTP37), a muramyl dipeptide as an adjuvant, and squalene/mannide monooleate as a vehicle. Toxicity consisted of pain and sterile abscess formation at the injection site and of constitutional symptoms. Diphtheria toxoid hypersensitivity developed in one patient. Immunizations elicited anti-beta hCG IgG antibody which persisted for more than 10 months. Disappearance of circulating hCG present pre-immunization and tumor regressions were observed. Active specific immunotherapy with CTP37 vaccine is well-tolerated and has biological activity in patients with cancer.
authors.affiliation: OHIO STATE UNIV,CTR COMPREHENS CANC,ARTHUR G JAMES CANC HOSP & RES INST,COLUMBUS,OH 43210.
authors.forename: P
authors.initials: P
authors.lastname: Triozzi
authors.forename: D
authors.initials: D
authors.lastname: Gochnour
authors.forename: E
authors.initials: E
authors.lastname: Martin
authors.forename: W
authors.initials: W
authors.lastname: Aldrich
authors.forename: J
authors.initials: J
authors.lastname: Powell
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: D
authors.initials: D
authors.lastname: Young
authors.forename: J
authors.initials: J
authors.lastname: Lombardi