title: [Pleomorphism of the myelin-like bodies in the hepatocytes of patients with Dubin-Johnson syndrome complicated with chronic hepatitis B].
abstract: OBJECTIVE
  To explore characteristics of the myelin-like bodies in the hepatocytes of patients with Dubin-Johnson syndrome (DJS) complicated with chronic hepatitis B (CHB).
  
  
  METHODS
  11 cases of DJS complicated with CHB and 5 cases DJS without CHB were studied clinicopathologically. The hepatocyte ultrastructure was observed with transmission electron microscope and taken photos. The data were compared and analyzed using Fisher's Exact Test.
  
  
  RESULTS
  Deposition of myelin-like bodies can be observed in the hepatocytes of DJS patients with CHB but can not in DJS patients without CHB. The morphology of pigment varys. The electron density and volume of pigment in DJS patients with CHB can be classified into five types: brights (2/11,18.2%), reticulation (1/11, 9.1%), punctiform (6/11, 54.5%), abnormity (1/11, 9.1%) and primary type (1/11, 9.1%). The myelin-like bodies in the hepatocytes of patients with DJS are high density and round with membrance (we named it as primary type) (5/5, 100%).
  
  
  CONCLUSIONS
  The myelin-like bodies in the hepatocytes of DJS patients with CHB possess special pleomorphism and may have important diagnostic value.
authors.affiliation: Center of Liver Diseases, First Hospital, Xinjiang Medical University, Urumqi, China.
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Lu
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Qin
authors.initials: Q
authors.lastname: Xu
authors.forename: Yue-Xin
authors.initials: YX
authors.lastname: Zhang
authors.forename: Ze-Run
authors.initials: ZR
authors.lastname: Deng
authors.forename: An-Hua
authors.initials: AH
authors.lastname: Hu
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Liu
authors.forename: Rong-Fu
authors.initials: RF
authors.lastname: Lv
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000473:pathology*; D022781:Hepatocytes / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure*; D006801:Humans; D007566:Jaundice, Chronic Idiopathic / Q000150:complications / Q000473:pathology*; D008297:Male; D009186:Myelin Sheath / Q000648:ultrastructure*; D055815:Young Adult