title: [Two cases of urolithiasis induced by topiramate].
abstract: Topiramate is an antiepileptic medicine that has been used adjunctively in the treatment of refractory seizures in Japan since 2007. Topiramate has been shown to inhibit specific carbonic anhydrase activity in the kidney and may induce a distal type of renal tubular acidosis. Case 1 : A 22-year-old male was referred to our hospital after complaining of left flank pain. He developed a seizure disorder and had been using topiramate for 4 months. Drip infusion pyelography showed a left ureteral stone. Case 2 : A 7-year-old boy presented with gross hematuria. He developed West syndrome and had been using topiramate for 6 months. A computed tomographic scan showed a right kidney stone.
authors.affiliation: The Department of Urology, Osaka Kouseinennkin Hospital.
authors.forename: Ryo
authors.initials: R
authors.lastname: Fukumoto
authors.forename: Kinzo
authors.initials: K
authors.lastname: Katayama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hayashi
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuoka
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Fujimoto
authors.forename: Takuo
authors.initials: T
authors.lastname: Koide
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kashiwagi
authors.forename: Tetsuzou
authors.initials: T
authors.lastname: Tagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Onodera
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ishida
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D004827:Epilepsy / Q000188:drug therapy; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007223:Infant; D007669:Kidney Calculi / Q000139:chemically induced; D008297:Male; D013036:Spasms, Infantile / Q000188:drug therapy; D000077236:Topiramate; D052878:Urolithiasis / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose