title: Case report of undifferentiated endometrial sarcoma in association with osteoclast-like giant cells.
abstract: We describe the clinical, gross and microscopic features of undifferentiated uterine stromal sarcoma associated with osteoclast-like giant cells. A case of low-grade endometrial stromal sarcoma is already described in association with osteoclast-like giant cells; however, the current case differs in that the tumor was a high grade and did not show any evidence of smooth muscle or epithelioid differentiation and was shown to be strongly positive for CD10 and focally for WT-1 and Inhibin supporting an endometrial stromal origin. The associated osteoclast-like giant cells were abundant, evenly distributed within the tumor and showed strong positivity for CD68. Interestingly, rare (less than 2%) giant cells also showed weak cytoplasmic positivity for b-hCG. The tumor infiltrated deep into the myometrium and had marked lymphovascular invasion. Although the regional lymph nodes and peritoneal washings were negative, the lesion showed a highly aggressive clinical course. Despite treatment, the tumor disseminated within the abdominal cavity and lungs and ultimately led to the patient's demise within 9 months of the diagnosis.
authors.affiliation: Department of Pathology, 97 Amity Street, Brooklyn, NY 11201, USA.
authors.forename: Svetoslav
authors.initials: S
authors.lastname: Bardarov
authors.forename: Vadim
authors.initials: V
authors.lastname: Khachaturov
authors.forename: Patel
authors.initials: P
authors.lastname: Kirtesh
authors.forename: Elpidio
authors.initials: E
authors.lastname: Jimenez