title: Systemic and immune manifestations in myelodysplasia: a multicenter retrospective study.
abstract: OBJECTIVE
  The presence of systemic and/or immune manifestations in myelodysplasia has been currently reported. The influence of these manifestations on the natural outcome of myelodysplastic syndrome has to be considered. We present a multicenter retrospective study (2002-2009) of patients with myelodysplastic syndrome disclosing systemic and/or immune manifestations.
  
  
  METHODS
  Forty-six patients with myelodysplasia presenting with systemic and/or immune manifestations were compared in terms of survival with 189 patients with myelodysplasia lacking these features.
  
  
  RESULTS
  The clinical picture in these cases consisted of fever (13%), arthralgia or arthritis (13%), and cutaneous manifestations (67%). Four cases of systemic vasculitis have been reported in our series, and they have a worse prognosis. Immune anomalies were recorded in 29% of the cases, and the presence of cryoglobulins was also associated with a worse prognosis.
  
  
  CONCLUSIONS
  A difference in survival between patients with myelodysplastic syndrome with systemic manifestations and patients lacking these manifestations has been observed in the presence of systemic vasculitis and/or cryoglobulins.
authors.affiliation: Internal Medicine Department, University Hospital Angers, 4 rue Larrey, Angers, France.
authors.forename: A
authors.initials: A
authors.lastname: de Hollanda
authors.forename: A
authors.initials: A
authors.lastname: Beucher
authors.forename: D
authors.initials: D
authors.lastname: Henrion
authors.forename: A
authors.initials: A
authors.lastname: Ghali
authors.forename: C
authors.initials: C
authors.lastname: Lavigne
authors.forename: H
authors.initials: H
authors.lastname: Lévesque
authors.forename: M
authors.initials: M
authors.lastname: Hamidou
authors.forename: J F
authors.initials: JF
authors.lastname: Subra
authors.forename: N
authors.initials: N
authors.lastname: Ifrah
authors.forename: C
authors.initials: C
authors.lastname: Belizna
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000150:complications / Q000276:immunology; D001168:Arthritis / Q000150:complications / Q000276:immunology; D003450:Cryoglobulins / Q000276:immunology*; D005260:Female; D005334:Fever / Q000150:complications / Q000276:immunology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000276:immunology*; D012189:Retrospective Studies; D056647:Systemic Vasculitis / Q000150:complications* / Q000276:immunology
chemical_list: D003450:Cryoglobulins