title: Mild rhabdomyolysis after renal transplantation.
abstract: We present a kidney transplantation patient who developed rhabdomyolysis. The patient was initially immunosuppressed with tacrolimus, mycophenolate mofetil, steroids, and chimeric CD25 monoclonal antibody. He complained of severe precordial and appendicular pain on 25th day after the operation. The patient developed rhabdomyolysis manifested as a rise in serum creatine phosphkinase (CPK) and elevation of urinary myoglobulin at approximately the same time as his symptoms. Although he was switched from tacrolimus to cyclosporine (CYA), his muscle pain and levels of serum CPK did not improve. However, dividing the daily total amount of the calcinuerin inhibitors into more frequent doses in order to reach lower serum levels resolved the rhabdomyolysis. Therefore, we conclude that his rhabdomyolysis might be a dose-related problem of calcineurin inhibitor.
authors.affiliation: Department of Urology, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan. sho.i@f4.dion.ne.jp
authors.forename: Shoichi
authors.initials: S
authors.lastname: Iida
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishida
authors.forename: Naoshi
authors.initials: N
authors.lastname: Miyamoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shirakawa
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Shimizu
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Setoguchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Toki
authors.forename: Kazunari
authors.initials: K
authors.lastname: Tanabe
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage; D065095:Calcineurin Inhibitors; D016572:Cyclosporine / Q000008:administration & dosage; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D012206:Rhabdomyolysis / Q000209:etiology*; D016559:Tacrolimus / Q000008:administration & dosage
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid; D001379:Azathioprine; D016559:Tacrolimus