title: Prognostic value of nucleolar organizer regions and DNA ploidy in gastric-cancer.
abstract: The prognostic value of nucleolar organizer region (Ag-NOR) and ploidy status in 233 gastric cancer was determined. In addition, correlation of bromodeoxyuridine labeling indices (BrdU LIs) and Ag-NOR scores was studied. The proportion of Ag-NOR scores varied from 1.85 to 12.0 (mean, 3.6; S.D., 1.9). A significant correlation was found between Ag-NOR scores and BrdU LIs, tumor size, serosal invasion, and lymph node metastasis. By univariate analysis, Ag-NOR score was proved to be a significant prognostic indicator. However, Cox regression analysis revealed that Ag-NOR scores and DNA ploidy were not independent prognostic parameters. However, when the combination analysis of Ag-NOR scores and DNA ploidy was entered into the Cox model, this parameter emerged as an independent prognostic parameter. These studies indicate that Ag-NOR scores reflect proliferative activity of gastric cancer, and that the Ag-NOR scores may possibly be useful prognostic parameters, when combined with DNA ploidy.
authors.forename: Y
authors.initials: Y
authors.lastname: Yonemura
authors.forename: M
authors.initials: M
authors.lastname: Kaji
authors.forename: H
authors.initials: H
authors.lastname: Takamura
authors.forename: K
authors.initials: K
authors.lastname: Sugiyama
authors.forename: I
authors.initials: I
authors.lastname: Ninomiya
authors.forename: K
authors.initials: K
authors.lastname: Tsugawa
authors.forename: T
authors.initials: T
authors.lastname: Fujimura
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: A
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: G
authors.initials: G
authors.lastname: Nishimura
authors.forename: I
authors.initials: I
authors.lastname: Miyazaki