title: Differential patterns of spinal cord pathology induced by MP4, MOG peptide 35-55, and PLP peptide 178-191 in C57BL/6 mice.
abstract: In this study we demonstrate that experimental autoimmune encephalomyelitis (EAE) induced by the MBP-PLP fusion protein MP4, MOG peptide 35-55, or PLP peptide 178-191 in C57BL/6 mice, respectively, displays distinct features of CNS pathology. Major differences between the three models resided in (i) the region-/tract-specificity and disseminated nature of spinal cord degeneration, (ii) the extent and kinetics of demyelination, and (iii) the involvement of motoneurons in the disease. In contrast, axonal damage was present in all models and to a similar extent, proposing this feature as a possible morphological correlate for the comparable chronic clinical course of the disease induced by the three antigens. The data suggest that the antigen targeted in autoimmune encephalomyelitis is crucial to the induction of differential histopathological disease manifestations. The use of MP4-, MOG:35-55-, and PLP:178-191-induced EAE on the C57BL/6 background can be a valuable tool when it comes to reproducing and studying the structural-morphological diversity of multiple sclerosis.
authors.affiliation: Department of Anatomy I, University of Cologne, Germany. stefanie.kuerten@uk-koeln.de
authors.forename: Stefanie
authors.initials: S
authors.lastname: Kuerten
authors.forename: Traugott L
authors.initials: TL
authors.lastname: Gruppe
authors.forename: Laura-Maria
authors.initials: LM
authors.lastname: Laurentius
authors.forename: Christiane
authors.initials: C
authors.lastname: Kirch
authors.forename: Magdalena
authors.initials: M
authors.lastname: Tary-Lehmann
authors.forename: Paul V
authors.initials: PV
authors.lastname: Lehmann
authors.forename: Klaus
authors.initials: K
authors.lastname: Addicks
mesh_terms: D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000473:pathology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D016472:Motor Neuron Disease / Q000473:pathology; D004676:Myelin Basic Protein / Q000276:immunology; D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein / Q000009:adverse effects / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein / Q000009:adverse effects / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000009:adverse effects / Q000276:immunology*; D010641:Phenotype; D011993:Recombinant Fusion Proteins / Q000009:adverse effects / Q000276:immunology; D013116:Spinal Cord / Q000473:pathology*
chemical_list: C571327:Mog protein, mouse; D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; D011993:Recombinant Fusion Proteins; C094242:myelin proteolipid protein (178-191)