title: Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern.
abstract: This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. This may represent a gender-specific risk factor and a molecular link between melatonin and SAD.
authors.affiliation: Inserm U, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France.
authors.forename: M
authors.initials: M
authors.lastname: Delavest
authors.forename: C
authors.initials: C
authors.lastname: Even
authors.forename: N
authors.initials: N
authors.lastname: Benjemaa
authors.forename: M-F
authors.initials: MF
authors.lastname: Poirier
authors.forename: R
authors.initials: R
authors.lastname: Jockers
authors.forename: M-O
authors.initials: MO
authors.lastname: Krebs
mesh_terms: D016022:Case-Control Studies; D005260:Female; D050172:Genes, X-Linked; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007438:Introns; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D016574:Seasonal Affective Disorder / Q000235:genetics*; D012737:Sex Factors
chemical_list: C509754:GPR50 protein, human; D009419:Nerve Tissue Proteins; D043562:Receptors, G-Protein-Coupled