title: Pediatric osteosarcoma - treatment of the primary tumor with intravenous cis-diamminedichloroplatinum-ii (cdp) - comparison of the results with the reported efficacy of intraarterial cdp.
abstract: Intravenous cis-Diamminedichloroplatinum-II (CDP) was administered to 10 patients with osteosarcoma to treat the primary tumor in 8 and bone metastases in 2. Three patients also had pulmonary metastases. The intent was to deliver 7 courses (150 mg/M2 q 2 weeks) over 3 months (total cumulative dose 1050/mg/M2). However, this was only accomplished in 2 patients; in the remaining 8 the full course was not administered because of temporary renal insufficiency (3), tumor escape (1) and apparent response after 4-6 courses suggesting that no further benefit would accrue (4). Overall, clinical and/or radiologic responses were observed in 9 patients. In 6 of 9 tumors subjected to surgical resection (66%), necrosis in excess of 65% was observed. Optimum results were achieved with a cumulative dose of 600 mg/M2 administered over 6 weeks. These results suggest that intravenous CDP may be as efficacious as intra-arterial CDP which has produced similar responses.
authors.affiliation: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT DIAGNOST IMAGING,HOUSTON,TX 77030. UNIV TEXAS,MD ANDERSON CANC CTR,DIV PATHOL,HOUSTON,TX 77030.
authors.forename: N
authors.initials: N
authors.lastname: Jaffe
authors.forename: D
authors.initials: D
authors.lastname: Jaffe
authors.forename: A
authors.initials: A
authors.lastname: Raymond
authors.forename: P
authors.initials: P
authors.lastname: Pearson
authors.forename: R
authors.initials: R
authors.lastname: Robertson
authors.forename: E
authors.initials: E
authors.lastname: Kim