title: Sleep in thyrotoxicosis.
abstract: OBJECTIVE
  Pattern of sleep in hyperthyroid state / thyrotoxicosis has not been systematically studied. It is being characterized as poor without further elaboration. We analyzed the pattern of sleep in a large sample of individuals with thyrotoxicosis who came to our endocrine center in southern India.
  
  
  METHODS
  We identified individuals with the diagnosis of 'thyrotoxicosis' from our electronic medical record database, and evaluated clinical parameters and pattern of their sleep: difficulty in falling asleep (DFA), difficulty in maintaining sleep (DMS), excess daytime sleepiness). In the first phase, univariate analysis with logistic regression was performed. Multivariate logistic regression was performed in the next phase on variables with a P-value < 0.1: these were considered as potential categories/ variables.
  
  
  RESULTS
  In model response variable with DFA, multivariate logistic regression predicted that subjects with abnormal appetite (more 1.7 or less 2.2), change in bowel motion (loose 1.5 or constipation 2.8), in mood (easy loss of temper 3.4), change of voice -- hoarse 7.4 or moderately hoarse 3.1), tended to have higher chances of difficulty in falling asleep (DFA). Patients with tremor (yes = 5.4) had greater likelihood of difficulty in maintaining sleep (DMS).
  
  
  CONCLUSIONS
  Individuals with hyperthyroidism/thyrotoxicosis principally had difficulty in falling asleep DFA, which was related to hyperkinetic features.
authors.affiliation: Endocrine and Diabetes Centre, 15-12-15 Krishnanagar, Visakhapatnam-530 002, India.
authors.forename: G R
authors.initials: GR
authors.lastname: Sridhar
authors.forename: Venkata
authors.initials: V
authors.lastname: Putcha
authors.forename: G
authors.initials: G
authors.lastname: Lakshmi