title: An electroneutral macrocyclic iron(II) complex that enhances MRI contrast in vivo.
abstract: The first example of a macrocyclic ferrous complex, where two tetrazolyl pendent arms compensate the charge of the metal center, is synthesized and examined for its capacity to enhance MRI contrast in vitro and in vivo in the mouse.
authors.affiliation: Laboratoire de Chimie, UMR 5182 CNRS, Ecole Normale Superieure de Lyon, Lyon, France.
authors.forename: Fayçal
authors.initials: F
authors.lastname: Touti
authors.forename: Akhilesh Kumar
authors.initials: AK
authors.lastname: Singh
authors.forename: Philippe
authors.initials: P
authors.lastname: Maurin
authors.forename: Laurence
authors.initials: L
authors.lastname: Canaple
authors.forename: Olivier
authors.initials: O
authors.lastname: Beuf
authors.forename: Jacques
authors.initials: J
authors.lastname: Samarut
authors.forename: Jens
authors.initials: J
authors.lastname: Hasserodt
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D056831:Coordination Complexes; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging; D051379:Mice; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D005296:Ferrous Compounds; D047028:Macrocyclic Compounds; D013777:Tetrazoles