title: Fox factors fight over T cell quiescence.
abstract: The transcription factor Foxp1 helps maintain the quiescence of naive T cells by inhibiting IL-7Rα expression and diminishing signaling by the kinase Erk.
authors.affiliation: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
authors.forename: Cara N
authors.initials: CN
authors.lastname: Skon
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Jameson
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D049109:Cell Proliferation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000276:immunology / Q000378:metabolism; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D015851:Interleukin-7 / Q000494:pharmacology; D020930:MAP Kinase Kinase Kinases / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D011485:Protein Binding; D020395:Receptors, Interleukin-7 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism
chemical_list: D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; C467200:Foxo1 protein, mouse; C432917:Foxp1 protein, mouse; D015851:Interleukin-7; D020395:Receptors, Interleukin-7; D012097:Repressor Proteins; C415350:interleukin-7 receptor, alpha chain; D048049:Extracellular Signal-Regulated MAP Kinases; D020930:MAP Kinase Kinase Kinases