title: Implication of Wnt signaling in neuronal polarization.
abstract: Wnt ligands comprise a large family of secreted glycoproteins that control a variety of developmental processes including cell polarization in diverse organisms. Through various receptors present on receiving cells, Wnts initiate intracellular signaling cascades resulting in changes in gene transcription or cytoskeleton reorganization. Recently, several lines of evidence have suggested the role of Wnt signaling in establishing axon-dendrite polarity in developing neurons. In this review, we summarize the recent results related with the role of Wnt signaling in neuronal polarization.
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Yang
authors.forename: Zhen-Ge
authors.initials: ZG
authors.lastname: Luo
mesh_terms: D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism*
chemical_list: D051153:Wnt Proteins