title: Interference between PARPs and SIRT1: a novel approach to healthy ageing?
abstract: Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Switzerland.
authors.forename: Carles
authors.initials: C
authors.lastname: Cantó
authors.forename: Johan
authors.initials: J
authors.lastname: Auwerx
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D056564:Sirtuin 1 / Q000378:metabolism*
chemical_list: D011065:Poly(ADP-ribose) Polymerases; C447939:SIRT1 protein, human; D056564:Sirtuin 1