title: Donor or recipient TNF-A -308G/A polymorphism and acute rejection of renal allograft: A meta-analysis.
abstract: BACKGROUND
  Results from published studies on the association of donor or recipient TNF-A -308G/A polymorphism with acute rejection (AR) of renal allograft are inconsistent. We performed a meta-analysis to summarize the possible association.
  
  
  METHODS
  Studies were identified by searching PUBMED, EMBASE and Chinese National Knowledge Infrastructure (CNKI) databases until March 22, 2011. Meta-analysis was performed in a fixed/random-effect model using Revman 5.0.25 and STATA10.0.
  
  
  RESULTS
  Eight studies evaluating the association between donor TNF-A -308G/A polymorphism and acute rejection of renal allograft were identified. Pooled OR based on 460 cases (whose recipient developed AR) and 623 controls (whose recipient did not develop AR) was 1.44 (95% CI=1.05-1.99, p=0.03). No association was detected in the subgroup analysis based on ethnicity. 28 studies evaluating the association between recipient TNF-A -308G/A polymorphism and acute rejection were identified. Pooled OR based on 1411 cases (patients did not develop AR) and 2088 controls was 1.39 (95% CI=1.06-1.82, p=0.02). Two studies evaluating the association between recipient TNF-A -308G/A polymorphism and recurrent acute rejection were identified. Pooled OR based on 225 cases (patients with ≤1 AR) and 34 controls (patients with ≥2 AR) was 0.28 (95% CI=0.13-0.62, p=0.002).
  
  
  CONCLUSIONS
  Our meta-analysis provided evidence that TNF2 allele positive genotype of donor or recipient was associated with increased risk of incidence of acute rejection of renal allograft. Recipient TNF2 allele positive genotype is also associated with increased risk of recurrence of acute rejection of renal allograft. However, additional studies with large sample size and better study designs are warranted to verify our finding.
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Hu
authors.forename: Yi
authors.initials: Y
authors.lastname: Bai
authors.forename: Siyue
authors.initials: S
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Zeng
authors.forename: Luhang
authors.initials: L
authors.lastname: Xu
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Liu
authors.forename: Xingbo
authors.initials: X
authors.lastname: Song
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Lu
authors.forename: Lanlan
authors.initials: L
authors.lastname: Wang
authors.forename: Binwu
authors.initials: B
authors.lastname: Ying
mesh_terms: D000208:Acute Disease; D006084:Graft Rejection / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D015201:Meta-Analysis as Topic; D020641:Polymorphism, Single Nucleotide; D039781:PubMed; D012307:Risk Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha