title: Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice.
abstract: A series of chelants (3a-s) composed of a glucosyl tail, an amino acid side chain and a dithiocarbamate group were designed, synthesized, and evaluated. By co-administering with cisplatin, 3a-s were able to decrease the accumulation of platinum in the organs, maintain the accumulation of platinum in the tumor tissues, and increase the urinary and fecal platinum, as well as increasing the voided volume of the treated S180-bearing mice. Compared to S180-bearing mice treated with cisplatin alone, the co-administered mice lost no spleen, kidney, liver, brain and heart weights, lost less body weight, and showed no increase in tumor weight.
authors.affiliation: College of Pharmaceutical Sciences, Capital Medical University, Beijing 1000, 69, PR China.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Wei
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Shenghui
authors.initials: S
authors.lastname: Mei
authors.forename: Meiqing
authors.initials: M
authors.lastname: Zheng
authors.forename: Yifan
authors.initials: Y
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Gong
authors.initials: G
authors.lastname: Chen
authors.forename: Shiqi
authors.initials: S
authors.lastname: Peng
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D019610:Cytoprotection; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D010984:Platinum / Q000378:metabolism / Q000633:toxicity; D013859:Thiocarbamates / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D014018:Tissue Distribution
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents; D013859:Thiocarbamates; D010984:Platinum; D002945:Cisplatin