title: Release of serum S-100β protein and neuron-specific enolase after off-pump coronary artery bypass grafting with and without intracranial and cervical artery stenosis.
abstract: OBJECTIVE
  The aim of this study was to quantify the amount of brain damage suffered by patients who underwent off-pump coronary artery bypass grafting (OPCAB) in which S-100β protein and neuron-specific enolase were used.
  
  
  METHODS
  Thirty-four patients undergoing scheduled OPCAB were enrolled in the study. The patients were divided into two groups according to the results of their magnetic resonance angiography (MRA) and cervical ultrasonography: 13 patients had cervical or intracranial arterial stenosis (Group A), and 21 patients did not (Group B). Blood samples were collected from the arterial catheters immediately before surgery, upon arrival to the intensive care unit, and 6 and 24 hours after surgery.
  
  
  RESULTS
  In blood samples collected from patients upon arrival to the intensive care unit, the maximum concentration of serum s-100β protein in Group A was significantly higher than that of Group B (p = 0.029). Though patients in Group A tended to have higher maximum neuron-specific enolase (NSE) concentrations, there were no significant differences in NSE concentrations at any point between the two groups.
  
  
  CONCLUSIONS
  Our findings show a correlation between the stenosis detected by MRA or cervical ultrasonography and brain damage after OPCAB.
authors.affiliation: Department of Surgery, Division of Cardiovascular Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan. atamura@jichi.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tamura
authors.forename: Mizuho
authors.initials: M
authors.lastname: Imamaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shimura
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Niitsuma
authors.forename: Masaru
authors.initials: M
authors.lastname: Miyazaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001927:Brain Diseases / Q000097:blood / Q000209:etiology*; D002533:Cerebral Angiography; D002574:Cervical Vertebrae / Q000098:blood supply*; D016009:Chi-Square Distribution; D003251:Constriction, Pathologic; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D020765:Intracranial Arterial Diseases / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D007564:Japan; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase