title: Pharmacokinetics of Carboplatin in a patient with both testicular cancer and hemodialysis-requiring kidney failure.
abstract: We report on a patient with advanced seminoma successfully treated with 4 cycles of carboplatin (80-100 mg/m2 per cycle) and etoposide (240-300 mg/m2) while being on hemodialysis 3 times weekly. Hemodialysis was performed on day 2 and day 3 of each chemotherapy cycle. Plasma platinum levels were determined at regular intervals at days 1, 2 and 3 of each cycle. The drug doses for cycle 2-4 were reduced due to grade 4 hematological toxicity during the preceding cycle. In spite of these drug reductions the AUC between 0-51 h remained unchanged for all cycles. Platinum was found in the plasma collected on day 1 of cycle 2-4 prior to start of the scheduled carboplatin infusion. The demonstrated pharmacokinetics of carboplatin (and probably also of etoposide) should be considered during chemotherapy of a testicular cancer patient on hemodialysis.
authors.affiliation: NATL HOSP NORWAY,NAT HOSP,DEPT MED,N-0027 OSLO,NORWAY. NATL HOSP NORWAY,NAT HOSP,DEPT SURG,N-0027 OSLO,NORWAY. NORWEGIAN RADIUM HOSP,DEPT MED ONCOL & RADIOTHERAPY,N-0310 OSLO,NORWAY.
authors.forename: K
authors.initials: K
authors.lastname: Hall
authors.forename: K
authors.initials: K
authors.lastname: Nordal
authors.forename: I
authors.initials: I
authors.lastname: Brekke
authors.forename: S
authors.initials: S
authors.lastname: Fossa