title: Torsades-de-Pointes associated with Taku-Tsubo cardiomyopathy following greatly reduced oxycodone use in an elderly woman.
abstract: This article reports an elderly female oxycodone consumer who developed Torsades-de-Pointes soon after her opioid-associated rate-corrected QT interval (QTC, a standard measurement on electrocardiograms) prolongation had been augmented by the development of Taku-Tsubo cardiomyopathy (TC), a sequence that followed greatly reduced oxycodone ingestion. Factors that likely contributed to this sequence are discussed, including direct opioid-induced inhibition of human ether-a-go-go-related gene activity and of androgen formation plus QTc prolongation induced by the presence of TC.
authors.affiliation: Department of Family Practice, University of California Medical School at Davis, Redding, California, USA.
authors.forename: Harry W
authors.initials: HW
authors.lastname: Daniell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000009:adverse effects*; D009202:Cardiomyopathies / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D010098:Oxycodone / Q000009:adverse effects*; D016171:Torsades de Pointes / Q000139:chemically induced*
chemical_list: D000701:Analgesics, Opioid; D010098:Oxycodone