title: Scc1 (CP0432) and Scc4 (CP0033) function as a type III secretion chaperone for CopN of Chlamydia pneumoniae.
abstract: The Chlamydia pneumoniae CopN protein is a member of the YopN/TyeA/InvE/MxiC family of secreted proteins that function to regulate the secretion of type III secretion system (T3SS) translocator and effector proteins. In this study, the Scc1 (CP0432) and Scc4 (CP0033) proteins of C. pneumoniae AR-39 were demonstrated to function together as a type III secretion chaperone that binds to an N-terminal region of CopN. The Scc1/Scc4 chaperone promoted the efficient secretion of CopN via a heterologous T3SS, whereas, the Scc3 chaperone, which binds to a C-terminal region of CopN, reduced CopN secretion.
authors.affiliation: Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Silva-Herzog
authors.forename: Sabrina S
authors.initials: SS
authors.lastname: Joseph
authors.forename: Ann K
authors.initials: AK
authors.lastname: Avery
authors.forename: Jose A
authors.initials: JA
authors.lastname: Coba
authors.forename: Katerina
authors.initials: K
authors.lastname: Wolf
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Fields
authors.forename: Gregory V
authors.initials: GV
authors.lastname: Plano
mesh_terms: D020816:Amino Acid Motifs; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016993:Chlamydophila pneumoniae / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018832:Molecular Chaperones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D021381:Protein Transport
chemical_list: D001426:Bacterial Proteins; D018832:Molecular Chaperones