title: Exploring the oxidative cyclization of substituted N-aryl enamines: Pd-catalyzed formation of indoles from anilines.
abstract: The direct Pd-catalyzed oxidative coupling of two C-H-bonds within N-aryl-enamines 1 allows the efficient formation of differently substituted indoles 2. In this cross-dehydrogenative coupling, many different functional groups are tolerated and the starting material N-aryl-enamines 1 can be easily prepared in one step from commercially available anilines. In addition, the whole sequence can also be run in a one-pot fashion. Optimization data, mechanistic insight, substrate scope, and applications are reported in this full paper.
authors.affiliation: Bayer CropScience AG, Alfred-Nobel-Strasse 50, 40789 Monheim am Rhein, Germany.
authors.forename: Julia J
authors.initials: JJ
authors.lastname: Neumann
authors.forename: Souvik
authors.initials: S
authors.lastname: Rakshit
authors.forename: Thomas
authors.initials: T
authors.lastname: Dröge
authors.forename: Sebastian
authors.initials: S
authors.lastname: Würtz
authors.forename: Frank
authors.initials: F
authors.lastname: Glorius
mesh_terms: D000588:Amines / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D000814:Aniline Compounds; D007211:Indoles; D010165:Palladium