title: Overview of endocrine systems in primary hypertension.
abstract: Multiple hormonal factors play a major role in the functional and structural abnormalities of hypertension (HT). At present, the kidneys and, in particular, renal Na(+) retention are thought to constitute a primary and sustaining mechanism in the development of HT. However, the precise renal and hormonal mechanisms leading to increased Na(+) reabsorption and HT remain unknown. Because the vast majority of HT is primary, this article focuses on the major endocrine systems, the RAS, aldosterone, and the SNS, that play a prominent role in the pathogenesis of HT.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, PO Box 801414, Charlottesville, VA 22908-1414, USA. rmc4c@virginia.edu
authors.forename: Robert M
authors.initials: RM
authors.lastname: Carey
mesh_terms: D000818:Animals; D004703:Endocrine System / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism; D008901:Mineralocorticoids / Q000097:blood / Q000378:metabolism; D018161:Receptors, Mineralocorticoid / Q000378:metabolism; D012084:Renin-Angiotensin System; D015398:Signal Transduction; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D008901:Mineralocorticoids; D018161:Receptors, Mineralocorticoid