title: Transforming growth factor β1 +869T/C gene polymorphism and essential hypertension: a meta-analysis involving 2708 participants in the Chinese population.
abstract: BACKGROUND
  The transforming growth factor β1 (TGFB1) +869T/C gene polymorphism has been suggested to be linked to susceptibility to essential hypertension (EH).
  
  
  OBJECTIVE
  To investigate the relationship between TGFB1 +869T/C gene polymorphism and EH, 5 separate studies with 2,708 subjects in the Chinese population on the relation between TGFB1 +869T/C gene polymorphism and EH were analyzed by meta-analysis. The random effect model was selected to calculate the pooled odds ratio (ORs) and its corresponding 95% confidence interval (95%).
  
  
  RESULTS
  There was a significant association between TGFB1 +869T/C gene polymorphism and EH. The pooled OR for CC/TC+TT genotype was 2.50 (95% CI: 1.46-4.28, P (heterogeneity) <0.0001, p=0.0008). The pooled OR for the frequency of C allele was 1.43 (95% CI:1.18-1.73, P (heterogeneity) =0.02, p=0.0002).
  
  
  CONCLUSIONS
  The current meta-analysis suggested that C allele and CC genotype of TGFB1 +869T/C gene polymorphism might be related to the increased risk of EH in the Chinese population.
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, China. lyynjmu123@126.com
authors.forename: Li
authors.initials: L
authors.lastname: Yan-Yan
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1