title: [Pathophysiology of asthma].
abstract: Asthma pathophysiology involves bronchial hyperreactivity, inflammation and remodelling, these features being closely linked. Bronchial hyperreactivity is characterized by an excessive airway response to a wide range of stimuli. Bronchial inflammation is characterized by an infiltration of all layers of the bronchial wall by a variety of inflammatory cells, especially mast cells, lymphocytes and eosinophils. Bronchial remodelling is defined by various structural alterations of all components of the bronchial wall, which is responsible for a worsening of the disease.
authors.affiliation: Université de Bordeaux, UB2, Centre de Recherche Cardio-thoracique, CIC 0005, F-33076 Bordeaux, France.
authors.forename: Annaïg
authors.initials: A
authors.lastname: Ozier
authors.forename: Imane
authors.initials: I
authors.lastname: Bara
authors.forename: Pierre-Olivier
authors.initials: PO
authors.lastname: Girodet
authors.forename: Roger
authors.initials: R
authors.lastname: Marthan
authors.forename: Patrick
authors.initials: P
authors.lastname: Berger
mesh_terms: D001249:Asthma / Q000276:immunology / Q000503:physiopathology*; D006801:Humans