title: A proposal to speed translation of healthcare research into practice: dramatic change is needed.
abstract: Efficacy trials have generated interventions to improve health behaviors and biomarkers. However, these efforts have had limited impact on practice and policy. It is suggested that key methodologic and contextual issues have contributed to this state of affairs. Current research paradigms generally have not provided the answers needed for more probable and more rapid translation. A major shift is proposed to produce research with more rapid clinical, public health, and policy impact.
authors.affiliation: College of Medicine, University of Vermont, Burlington, VT 05405, USA. rodger.kessler@uvm.edu
authors.forename: Rodger
authors.initials: R
authors.lastname: Kessler
authors.forename: Russell E
authors.initials: RE
authors.lastname: Glasgow
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D015438:Health Behavior; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000639:trends*; D012106:Research / Q000639:trends*; D012107:Research Design; D013997:Time Factors; D057170:Translational Research, Biomedical / Q000379:methods / Q000639:trends*
chemical_list: D015415:Biomarkers