title: Enantioselective synthesis of highly substituted furans by a copper(II)-catalyzed cycloisomerization-indole addition reaction.
abstract: A catalytic enantioselective reaction based on a copper(II) catalyst strictly containing chiral anionic ligands is described. In the present work, copper(II)-phosphate catalyst promotes the intramolecular heterocyclization of 2-(1-alkynyl)-2-alkene-1-ones and facilitates high levels of enantioselectivity in the subsequent nucleophile attack. Mechanistic studies suggest that formation of a copper(II)-indole species is important for catalysis.
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Rauniyar
authors.forename: Z Jane
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Heather E
authors.initials: HE
authors.lastname: Burks
authors.forename: F Dean
authors.initials: FD
authors.lastname: Toste