title: Understanding the cross-talk between ovarian tumors and immune cells: mechanisms for effective immunotherapies.
abstract: Despite decades of research, ovarian cancer remains a lethal disease. Recent studies have reported the critical role played by the immune system in controlling growth and spread of ovarian tumors. Accordingly, immunotherapy has been indicated as the most likely successful new approach in the treatment of the disease. Unfortunately, ovarian cancer triggers immune inhibitory mechanisms that hamper anti-tumor responses. Therefore, future immunotherapies should be able to overcome these obstacles. Here we review the basic mechanisms of tumor immune surveillance with a particular focus on ovarian cancer, and we discuss cutting-edge strategies to promote immune system eradication of ovarian tumors.
authors.affiliation: Department of Internal Medicine at Division of Hematology/Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, Texas 79430, USA. maurizio.chiriva@ttuhsc.edu
authors.forename: Maurizio
authors.initials: M
authors.lastname: Chiriva-Internati
authors.forename: Leonardo
authors.initials: L
authors.lastname: Mirandola
authors.forename: W Martin
authors.initials: WM
authors.lastname: Kast
authors.forename: Marjorie R
authors.initials: MR
authors.lastname: Jenkins
authors.forename: Everardo
authors.initials: E
authors.lastname: Cobos
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Cannon
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D000229:Dependovirus / Q000235:genetics / Q000276:immunology; D005260:Female; D005822:Genetic Vectors / Q000008:administration & dosage; D006801:Humans; D007157:Immunologic Surveillance / Q000276:immunology*; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D019496:Cancer Vaccines