title: Case-control study of male cancer patients exposed to arsenic-contaminated drinking water and tobacco smoke with relation to non-exposed cancer patients.
abstract: The investigated data indicated that inorganic arsenic in drinking water is associated with increased mortality from different types of cancers. In the present study, biological samples (blood and scalp hair) of male subjects having lung and bladder cancers and non-cancerous subjects belonging to arsenic (As)-exposed area of southern parts of Pakistan were analysed for As contents. The As levels in drinking water of understudy area showed that sections of understudy population are exposed to arsenic concentrations, which was 3-15-fold higher than the permissible level (<10 μg/L). For comparative purposes the biological samples of matched male cancer patient, as referent patients belonging to big city (Hyderabad) who had used municipal treated water with low arsenic levels <10 μg/L, were also collected. The exposed cancer patients have 2-3-fold higher level of As in both biological samples compared to non-exposed case-matched cancerous male subjects. This study is compelling evidence in support of positive associations between arsenic-contaminated water, food and cigarette with different types of risks of cancer.
authors.affiliation: Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan. wadhwashamkumar@yahoo.com
authors.forename: Sham Kumar
authors.initials: SK
authors.lastname: Wadhwa
authors.forename: Tasneem Gul
authors.initials: TG
authors.lastname: Kazi
authors.forename: Nida Fatima
authors.initials: NF
authors.lastname: Kolachi
authors.forename: Hassan Imran
authors.initials: HI
authors.lastname: Afridi
authors.forename: Sumaira
authors.initials: S
authors.lastname: Khan
authors.forename: Akhtar Ali
authors.initials: AA
authors.lastname: Chandio
authors.forename: Abdul Qadir
authors.initials: AQ
authors.lastname: Shah
authors.forename: Ghulam Abbas
authors.initials: GA
authors.lastname: Kandhro
authors.forename: Syeda
authors.initials: S
authors.lastname: Nasreen
mesh_terms: D001152:Arsenicals / Q000009:adverse effects* / Q000378:metabolism; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D016022:Case-Control Studies; D004357:Drug Synergism; D004781:Environmental Exposure / Q000009:adverse effects*; D006197:Hair / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000401:mortality; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D012907:Smoking / Q000009:adverse effects*; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000401:mortality; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000378:metabolism; D014881:Water Supply / Q000032:analysis
chemical_list: D001152:Arsenicals; D002274:Carcinogens, Environmental; D014874:Water Pollutants, Chemical