title: Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea.
abstract: We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) and (99m)Tc-labeled tropane dopamine transporter ((99m)Tc-TRODAT-1) single photon emission computed tomography (SPECT). Along with normalization of the hematocrit and clinical symptoms after consecutive phlebotomies, the FDG PET scan and (99m)Tc-TRODAT-1 SPECT images returned towards normal. It is hypothesized that the development of polycythemia chorea is associated with a reversible alteration in the corticobasal ganglia metabolism and disturbed dopaminergic function.
authors.affiliation: Department of Neurology, China Medical University Hospital, 404 Taichung, Taiwan.
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Huang
authors.forename: Yu-Chin
authors.initials: YC
authors.lastname: Wu
authors.forename: Lee-Yung
authors.initials: LY
authors.lastname: Shih
authors.forename: Woei-Chung
authors.initials: WC
authors.lastname: Lo
authors.forename: Chon-Haw
authors.initials: CH
authors.lastname: Tsai
authors.forename: Woei-Cherng
authors.initials: WC
authors.lastname: Shyu
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D002819:Chorea / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D006801:Humans; D011087:Polycythemia Vera / Q000000981:diagnostic imaging* / Q000378:metabolism; D049268:Positron-Emission Tomography; D015899:Tomography, Emission-Computed, Single-Photon