title: [Radionuclide methods for diagnostics of non-rheumatic myocarditis and postmyocarditic cardiosclerosis].
abstract: We compared the results of comprehensive scintigraphic examination of 35 patients with suspected myocarditis and the data of clinical, immunological, laboratory and instrumental studies. The patients were divided into 3 groups. Group 1 included 11 patients with preliminary diagnosis of acute myocarditis, group 2--11 patients with chronic myocarditis, group 3--13 patients with postmyocarditic cardiosclerosis. All patients were tested for antimyocardial antibodies, underwent 99mTc-HMPAO-labeled leukocyte and perfusion scintiography of myocardium. The study did not reveal significant differences between the three groups as regards the results of laboratory and instrumental studies. Elevated titers of antimyocardial antibodies were found in 70% of the patients in group 1, 100% in group 2, and 46% in group 3. Patients with chronic myocarditis had the highest titers of antibodies. Pathological accumulation of 99mTc-HMPAO-labeled leukocytes in myocardium was documented in 36.4 and 81.8% of the patients of groups 1 and 2 respectively. They were absent in the heart of group 3 patients. Disturbed myocardial perfusion was recorded in 45.5, 81.8 and 84.6% in groups 1, 2 and 3 respectively. The magnitude of accumulation of leukocytes was not significantly different between the groups. Results of the study suggest rather high specificity of radionuclide techniques for diagnostics of inflammatory lesions in myocardium. However, further studies are needed to confirm their sensitivity and accuracy.
authors.forename: S I
authors.initials: SI
authors.lastname: Sazonova
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Proskokova
authors.forename: A M
authors.initials: AM
authors.lastname: Guseva
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Konkovskaia
authors.forename: A A
authors.initials: AA
authors.lastname: Garganeeva
authors.forename: T E
authors.initials: TE
authors.lastname: Suslova
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Lishmanov
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007962:Leukocytes / Q000000981:diagnostic imaging; D008297:Male; D009205:Myocarditis / Q000000981:diagnostic imaging* / Q000276:immunology; D009206:Myocardium / Q000276:immunology / Q000473:pathology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012598:Sclerosis / Q000000981:diagnostic imaging / Q000276:immunology; D019690:Technetium Tc 99m Exametazime; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime