title: Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS).
abstract: We examined oxidative stress markers, tau protein and cytokines in the cerebrospinal fluid (CSF) in six patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). In the CSF, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct levels increased over the cutoff index in four and one out of six MERS patients, respectively. The CSF IL-6 and IL-10 levels were increased in three out of six patients, two of which had extended lesion of the cerebral white matter. The CSF value of tau protein, marker of the axonal damage, was not increased, and neuron specific enolase (NSE) in the CSF was not increased. The increased 8-OHdG levels in the CSF, DNA oxidative stress marker, in four MERS patients, suggesting involvement of oxidative stress in MERS. MERS is occasionally accompanied with hyponatremia, although our patients lacked hyponatremia. It is possible that the disequilibrium of systemic metabolism including electrolytes may lead to facilitation of oxidative stress and reversible white matter lesion in MERS. The increase of cytokine production seems to be involved in the distribution of lesions in MERS.
authors.affiliation: Department of Pediatrics, Tokyo-Kita Social Insurance Hospital, Kita-ku, Tokyo, Japan. rie88miyata@ybb.ne.jp
authors.forename: Rie
authors.initials: R
authors.lastname: Miyata
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Tanuma
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hayashi
authors.forename: Takuji
authors.initials: T
authors.lastname: Imamura
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Takanashi
authors.forename: Rieko
authors.initials: R
authors.lastname: Nagata
authors.forename: Akihisa
authors.initials: A
authors.lastname: Okumura
authors.forename: Hirohumi
authors.initials: H
authors.lastname: Kashii
authors.forename: Sunao
authors.initials: S
authors.lastname: Tomita
authors.forename: Satoko
authors.initials: S
authors.lastname: Kumada
authors.forename: Masaya
authors.initials: M
authors.lastname: Kubota
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D001927:Brain Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000378:metabolism / Q000473:pathology*; D016207:Cytokines / Q000134:cerebrospinal fluid; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid; D004660:Encephalitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011863:Radioimmunoassay; D012964:Sodium / Q000097:blood; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016207:Cytokines; D016875:tau Proteins; D000080242:8-Hydroxy-2'-Deoxyguanosine; D012964:Sodium; D010751:Phosphopyruvate Hydratase; D003849:Deoxyguanosine