title: Immunobiological properties of selected natural and chemically modified phenylpropanoids.
abstract: Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by lipopolysaccharide (LPS) and interferon-γ (IFN-γ), tested under in vitro conditions using murine resident peritoneal macrophages, are reviewed. Relation between the molecular structure and immunobiological activity was investigated, and implication of substituents, double bond stereochemistry, or cyclic attachments (double bond geometry fixation) was assessed. The focus was on lignans and stilbenoids because they were originally selected for a joint project of common interest to phytochemical and pharmacological investigation and because they represent well interesting and universally attractive groups of polyphenols with a feasible potential for therapeutic or nutraceutic utilization.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences, v.v.i., Flemingovo nám. 2, CZ-166 10 Prague, Czech Republic.
authors.forename: Juraj
authors.initials: J
authors.lastname: Harmatha
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Zídek
authors.forename: Eva
authors.initials: E
authors.lastname: Kmoníčková
authors.forename: Jan
authors.initials: J
authors.lastname: Smidrkal