title: The Cerebral Palsy Demonstration Project: a multidimensional research approach to cerebral palsy.
abstract: Cerebral palsy is the most common cause of physical impairment in pediatrics. As a heterogeneous disorder in all its disparate aspects it defies a simplistic research approach that seeks to further our understanding of its mechanisms, outcomes and treatments. Within NeuroDevNet, with its focus on abnormal brain development, cerebral palsy was selected as one of the three neurodevelopmental disabilities to be the focus of a dedicated demonstration project. The Cerebral Palsy Demonstration Project will feature a multi-dimensional approach utilizing epidemiologic, imaging, genetics, animal models and stem cell modalities that will at all times emphasize clinical relevance, translation into practice, and potential synergies between investigators now segregated by both academic disciplines and geographic distance. The objective is to create a national platform of varied complementary and inter-digitated efforts. The specific research plan to enable this will be outlined in detail.
authors.affiliation: Department of Neurology/Neurosurgery, McGill University, Montreal, Canada. nazeem.muhajarine@usask.ca
authors.forename: Michael
authors.initials: M
authors.lastname: Shevell
authors.forename: Steven P
authors.initials: SP
authors.lastname: Miller
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Scherer
authors.forename: Jerome Y
authors.initials: JY
authors.lastname: Yager
authors.forename: Michael G
authors.initials: MG
authors.lastname: Fehlings
mesh_terms: D000818:Animals; D001931:Brain Mapping / Q000379:methods; D002170:Canada; D002547:Cerebral Palsy / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D004195:Disease Models, Animal; D006078:Government Programs / Q000458:organization & administration*; D006801:Humans; D058025:Interdisciplinary Studies; D016730:Program Development; D057170:Translational Research, Biomedical / Q000458:organization & administration*