title: Bacteremia in human immunodeficiency virus-infected children in Cape Town, South Africa.
abstract: Bacteremia contributes to morbidity of HIV-infected children. In a randomized controlled trial evaluating trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis, 47 bacteremias were detected. The incidence rate of bacteremia increased in the first 3 months after starting combination antiretroviral therapy (cART), but decreased by 74% once children were established on cART for more than 3 months. Children should be prioritized for early cART.
authors.affiliation: Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. DrDaveleRoux@gmail.com
authors.forename: David M
authors.initials: DM
authors.lastname: le Roux
authors.forename: Mark F
authors.initials: MF
authors.lastname: Cotton
authors.forename: Stanzi M
authors.initials: SM
authors.lastname: le Roux
authors.forename: Andrew
authors.initials: A
authors.lastname: Whitelaw
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Lombard
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Zar
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis / Q000379:methods*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D016470:Bacteremia / Q000453:epidemiology* / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D013019:South Africa / Q000453:epidemiology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage*
chemical_list: D019380:Anti-HIV Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination