title: Ect and platelet 5ht uptake in major depression.
abstract: Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The mechanism of antidepressant action of ECT is not clear. The present work was undertaken with the aim to study the active platelet 5-HT uptake and the effect of ECT on it in patients of major depression. 15 patients of major depression (DSM-lll-R) and equal number of age and sex-matched controls were included in the study. Active platelet 5-HT uptake was determined before ECT, after a course of ECT and 7 days after last ECT. Platelet 5-HT uptake was. significantly lower in der essives than normal controls. After ECT treatment there was significant increase in 5-HT uptake which came down to pretreatment level after 1 week of last ECT. The effect of ECT on serotonergic system is discussed.
authors.affiliation: P.K. DALAL, MD., Associate Professor, Department of Psychiatry, K.G'S Medical College, Lucknow-226003.
authors.forename: P K
authors.initials: PK
authors.lastname: Dalal
authors.forename: N
authors.initials: N
authors.lastname: Lal
authors.forename: J K
authors.initials: JK
authors.lastname: Trivedi
authors.forename: P K
authors.initials: PK
authors.lastname: Seth
authors.forename: A K
authors.initials: AK
authors.lastname: Agarwal
authors.forename: A
authors.initials: A
authors.lastname: Khalid