title: Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNA.
abstract: Quantum chemical calculations reveal that neither steric hindrance nor less polar solvent medium is able to reduce the otherwise high hydrolysis rate of arsenate-esters. These results question the stability of As-DNA not only in aqueous but also in non-aqueous environments.
authors.affiliation: Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
authors.forename: Arnošt
authors.initials: A
authors.lastname: Mládek
authors.forename: Jiří
authors.initials: J
authors.lastname: Sponer
authors.forename: Bobby G
authors.initials: BG
authors.lastname: Sumpter
authors.forename: Miguel
authors.initials: M
authors.lastname: Fuentes-Cabrera
authors.forename: Judit E
authors.initials: JE
authors.lastname: Sponer
mesh_terms: D001149:Arsenates / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004952:Esters; D006868:Hydrolysis; D007700:Kinetics; D008962:Models, Theoretical; D011789:Quantum Theory; D012997:Solvents / Q000737:chemistry
chemical_list: D001149:Arsenates; D004952:Esters; D012997:Solvents; D004247:DNA; C025657:arsenic acid