title: Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population.
abstract: PITX3 is a transcription factor which determines the survival of dopaminergic neurons in the substantia nigra, and is considered a candidate gene for Parkinson's disease (PD). Recent association studies indicated that three PITX3 single nucleotide polymorphisms (SNPs), including rs2281983, rs4919621, and rs3758549 are likely to be associated with PD. However, no similar associations in Chinese populations have been reported. To examine the nature of the association in Chinese individuals we analyzed DNA samples for these three PITX3 SNPs from 509 late-onset sporadic PD patients, and 494 healthy controls, using a ligase detection reaction (LDR). Results indicated that allele and genotype frequencies did not differ between patients and controls for all three SNPs, suggesting that these SNP sites do not contribute to the risk of developing PD in late-onset sporadic PD in this Chinese population.
authors.affiliation: Department of Neurology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, PR China. yanningcai@yahoo.com
authors.forename: Yanning
authors.initials: Y
authors.lastname: Cai
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.forename: Zhuqin
authors.initials: Z
authors.lastname: Gu
authors.forename: Jinghong
authors.initials: J
authors.lastname: Ma
authors.forename: Piu
authors.initials: P
authors.lastname: Chan
mesh_terms: D017668:Age of Onset; D000368:Aged; D000483:Alleles; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D022521:Ligase Chain Reaction; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors; C433629:homeobox protein PITX3