title: [Effect of glucosamine sulfate on the immunological function of normal mice].
abstract: OBJECTIVE
  To observe the effects of glucosamine sulfate on the immunity of normal mice.
  
  
  METHODS
  Female ICR mice were divided by weight into four groups, including low dose group (150 mg x kg(-1)), medium dose group (300 mg x kg(-1)), high dose group (900 mg x kg(-1)) and normal control group. Spleen and thymus were weighted 30 days later, cell mediated immunity, humoral immunity, phagocytosis of mononuclear phagocyte and the activity of NK cell were assayed.
  
  
  RESULTS
  The thymus index in high dose group was decreased significantly in compared with control group (P < 0.05). Compared with the control group, the delayed type hypersensitivity, serum hemolysin and the ability of antibody production were improved significantly in glucosamine sulfate groups (P < 0.05). The activity of NK cell in high dose group was higher than that of the control group (P < 0.05). The proliferation of spleen lymphocyte, the rate of phagocytosis and the carbon particle clearance index in all glucosamine sulfate groups were similar to those in the control group.
  
  
  CONCLUSIONS
  The immune function of normal mice could be enhanced by glucosamine sulfate, including cellular immunity, humoral immunity and the activity of NK cell.
authors.affiliation: Fujian Center for Disease Control and Prevention, Fuzhou 350001, China. chinacgm@sina.com
authors.forename: Guanmin
authors.initials: G
authors.lastname: Chen
authors.forename: Run
authors.initials: R
authors.lastname: Chen
authors.forename: Rongbiao
authors.initials: R
authors.lastname: Zhang
authors.forename: Xiufen
authors.initials: X
authors.lastname: Lin
authors.forename: Li
authors.initials: L
authors.lastname: Sun
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005944:Glucosamine / Q000494:pharmacology*; D007109:Immunity / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008813:Mice, Inbred ICR
chemical_list: D000276:Adjuvants, Immunologic; D005944:Glucosamine