title: How placebo responses are formed: a learning perspective.
abstract: Despite growing scientific interest in the placebo effect and increasing understanding of neurobiological mechanisms, theoretical conceptualization of the placebo effect remains poorly developed. Substantial mechanistic research on this phenomenon has proceeded with little guidance by any systematic theoretical paradigm. This review seeks to present a theoretical perspective on the formation of placebo responses. We focus on information processing, and argue that different kinds of learning along with individuals' genetic make-up evolved as the proximate cause for triggering behavioural and neural mechanisms that enable the formation of individual expectations and placebo responses. Conceptualizing the placebo effect in terms of learning offers the opportunity for facilitating scientific investigation with a significant impact on medical care.
authors.affiliation: National Center for Complementary and Alternative Medicine (NCCAM), National Institutes of Health, Bethesda, MD, USA. luana.colloca@nih.gov
authors.forename: Luana
authors.initials: L
authors.lastname: Colloca
authors.forename: Franklin G
authors.initials: FG
authors.lastname: Miller
mesh_terms: D006801:Humans; D007858:Learning; D008960:Models, Psychological; D015990:Placebo Effect; D012107:Research Design; D015398:Signal Transduction