title: The use of MatriDerm® and skin grafting in post-traumatic wounds.
abstract: The aim of this study was to prove the effectiveness of MatriDerm(®) combined with skin grafting versus skin grafting alone in post-traumatic wounds treatment. At the Department of Plastic and Reconstructive Surgery of the University of Rome Tor Vergata, we treated 60 patients: 30 patients with dermal substitutes (MatriDerm(®)) combined with autologous skin graft and 30 with skin graft alone. Two weeks after the first treatment, 95% of wounds treated with MatriDerm(®) and skin graft showed a re-epithelisation, whereas it was 75-80% in the control group. We used the Manchester Scar Scale (MSS) and patient's self-estimation scale to assess the outcomes. Mann-Whitney U test was performed for the five items of the MSS and the results were combined to those of patient's self-estimation scale and the re-epithelialisation percentage to test the significance between the two groups. These data confirm the evidence of the clinical use of MatriDerm(®) technology in the healing of soft tissue wounds and prove the effectiveness of combining MatriDerm(®) and skin grafting for the first time. Furthermore, we observed a percentage reduction of wound contraction and in the same time an improvement of elasticity, quality of scars tissue and dermal architecture.
authors.affiliation: Department of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Cervelli
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Brinci
authors.forename: Diana
authors.initials: D
authors.lastname: Spallone
authors.forename: Eleonora
authors.initials: E
authors.lastname: Tati
authors.forename: Ludovico
authors.initials: L
authors.lastname: Palla
authors.forename: Lucilla
authors.initials: L
authors.lastname: Lucarini
authors.forename: Barbara
authors.initials: B
authors.lastname: De Angelis
mesh_terms: D000328:Adult; D000368:Aged; D003094:Collagen; D004549:Elastin; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing; D014947:Wounds and Injuries / Q000473:pathology / Q000601:surgery*
chemical_list: C532298:matriderm; D003094:Collagen; D004549:Elastin