title: Intracystic negative pressure may promote bone formation around jaw cysts.
abstract: The growth and enlargement of jaw cysts are associated with raised intracystic pressure and bone resorption surrounding the cysts. The major bone-resorbing cells are the osteoclasts. They are acting under the influence of local bone-resorbing factors: prostaglandins, proteinases and cytokines. It was found that positive pressure enhanced the expression of IL-1αmRNA and protein in epithelial cells of odontogenic keratocyst, and increased the secretion of matrix metalloproteinase and PGE2 in a co-culture of odontogenic keratocyst fibroblasts and epithelial cells. However, the signal intensities for IL-1αmRNA and protein in the epithelium were significantly decreased after marsupialization which relived intracystic pressure. Experimental study indicated that intermittent negative pressure could promote osteogenesis in human bone marrow-derived stroma cells (BMSCs) in vitro. We propose a hypothesis that bone formation around the cyst of the jaws would be stimulated by intracystic negative pressure.
authors.affiliation: Department of Prosthodontics, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei Province, China. zhao-yi@163.com
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Qi-Bing
authors.initials: QB
authors.lastname: Han
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
mesh_terms: D016207:Cytokines; D005347:Fibroblasts; D006801:Humans; D007568:Jaw; D007570:Jaw Cysts; D009807:Odontogenic Cysts; D009808:Odontogenic Tumors; D010012:Osteogenesis
chemical_list: D016207:Cytokines; C025940:bone resorption factor