title: Synthesis and antimicrobial evaluation of new benzofuran derivatives.
abstract: Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S.aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC(80) = 0.39-3.12 μg/mL), which were better than the control drugs.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Shanghai 200240, PR China.
authors.forename: Xizhen
authors.initials: X
authors.lastname: Jiang
authors.forename: Wenlu
authors.initials: W
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Faqin
authors.initials: F
authors.lastname: Jiang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Gao
authors.forename: Hao
authors.initials: H
authors.lastname: Zhuang
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects* / Q000254:growth & development; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D049109:Cell Proliferation / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D016106:Methicillin Resistance / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001572:Benzofurans