title: Esophageal motor abnormalities in eosinophilic esophagitis identified by high-resolution manometry.
abstract: OBJECTIVE
  Esophageal motility abnormalities, as measured by conventional manometry (CM), are non-specific in the majority of patients with eosinophilic esophagitis (EoE). Moreover, the study of CM is limited by poor interobserver agreement. The aims of the present study were: (i) to assess the esophageal patterns in EoE by a topographic analysis of high-resolution manometry (HRM) data; and (ii) to establish a relationship between motility abnormalities and symptoms of EoE, such as dysphagia and bolus impaction.
  
  
  METHODS
  All adult patients with EoE diagnosed according to histological criteria, and controls with gastroesophageal reflux disease symptoms and dysphagia, were included. HRM was done in EoE patients and controls. For the analysis of data, the Chicago classification was followed.
  
  
  RESULTS
  HRM was performed in 21 patients with EoE, as well as in 21 controls. Of the 21 patients with EoE, 10 (48%) showed pan-esophageal pressurization, six (28%) showed peristaltic dysfunction, and in five cases (24%), HRM was normal. There was no pan-esophageal pressurization in controls. Nine of 10 patients with pan-esophageal pressurization required endoscopic bolus removal (P < 0.05); none had obstructive endoscopy findings.
  
  
  CONCLUSIONS
  The most frequent esophageal motor abnormality measured by HRM was a pan-esophageal pressurization. Bolus impaction in patients with EoE was associated with pan-esophageal pressurization.
authors.affiliation: Department of Gastroenterology and Hepatology, País Vasco University, Donostia Hospital, San Sebastián, Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Martín Martín
authors.forename: Cecilio
authors.initials: C
authors.lastname: Santander
authors.forename: Mari Carmen
authors.initials: MC
authors.lastname: Lopez Martín
authors.forename: Jorge
authors.initials: J
authors.lastname: Espinoza-Ríos
authors.forename: Carlos
authors.initials: C
authors.lastname: Chavarría-Herbozo
authors.forename: Javier P
authors.initials: JP
authors.lastname: Gisbert
authors.forename: Ricardo
authors.initials: R
authors.lastname: Moreno-Otero
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001706:Biopsy; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D016145:Endoscopy, Digestive System; D057765:Eosinophilic Esophagitis / Q000150:complications*; D015154:Esophageal Motility Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010528:Peristalsis; D011237:Predictive Value of Tests; D011312:Pressure; D011446:Prospective Studies; D013030:Spain