title: Morphological effects of sinefungin, an inhibitor of S-adenosylmethionine-dependent methyltransferases, on Anabaena sp. PCC 7120.
abstract: Anabaena cells develop regular one-dimensional filaments through cell division in planes parallel to each other. A gcvP mutant displayed morphological defects such as filaments with sharp bends and/or branching and irregular cell clumps. The defects probably result from depletion of S-adenosylmethionine (AdoMet), because they were rescued by the application of methionine, an AdoMet precursor, and because sinefungin, a strong inhibitor of AdoMet-dependent methyltransferases, caused morphological abnormalities in wild-type Anabaena similar to those of the mutant. AdoMet-dependent methylation is involved in the spatial regulation of cell polarity in Anabaena.
authors.affiliation: Division of Theoretical Biology, National Institute for Basic Biology, Higashiyama 5-1, Myodaiji, Okazaki 444-8787, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Fujita
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Syono
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Machida
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kawaguchi