title: Unilateral deep brain stimulation in the nucleus accumbens core does not affect local monoamine release.
abstract: Recent publications have shown promising results of deep brain stimulation (DBS) in the nucleus accumbens for patients with obsessive compulsive disorder and major depressive disorder. Despite its increasing application in the clinical setting, the neurobiological mechanism of action of DBS is still uncertain. One of the possible effects of DBS might be phasic or tonic changes in monoamine release either locally in the target area or in a distant, connected region. In the present study we investigate whether unilateral DBS of the Nucleus Accumbens Core (NAc core) has a local effect on in vivo monoamine release. Freely moving animals were unilaterally stimulated with 300 μA or 400 μA (120 Hz, pulse width 80 μs) in the NAc core for 5 h. 1h before and during stimulation we measured dopamine, serotonin, their metabolites and noradrenaline using in vivo microdialysis. We found no significant effect of stimulation on extracellular concentrations of monoaminergic neurotransmitters or their metabolites in the NAc core during stimulation. Our results suggest that the rapid effects of DBS in the NAc are not a result of changes in local monoamine release in the NAc core. For future directions it is interesting to note that several microdialysis and electrophysiology studies have shown effects of DBS in areas distant from the stimulation target.
authors.affiliation: Department of Psychiatry, Academic Medical Center, University of Amsterdam, Postbus 22660, 1100 DD Amsterdam, The Netherlands. a.vandijk@amc.nl
authors.forename: Addy
authors.initials: A
authors.lastname: van Dijk
authors.forename: Oliver
authors.initials: O
authors.lastname: Mason
authors.forename: Andre A
authors.initials: AA
authors.lastname: Klompmakers
authors.forename: Matthijs G P
authors.initials: MG
authors.lastname: Feenstra
authors.forename: Damiaan
authors.initials: D
authors.lastname: Denys
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D046690:Deep Brain Stimulation / Q000379:methods*; D008297:Male; D017551:Microdialysis / Q000379:methods*; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D002395:Catecholamines; D012701:Serotonin