title: Antiphospholid antibody syndrome and Hb E/Beta thalassemia disease post-allogeneic stem cell transplantation.
abstract: We report a 10-year-old male with Hb E/Beta thalassemia disease who developed chronic graft-versus-host disease (cGVHD) of antiphospholipid antibody syndrome after successful allogeneic stem cell transplantation (SCT). He exhibited a recurrent ischemic stroke on day 368 post-SCT while on cyclosporine A, azathioprine, and prednisolone. The immunosuppressive agents were switched to pulse methylprednisolone, tacolimus, mycophenolate mofetil, and enoxaparin, but the patient was more confused. An additional plasma exchange which was aimed at the immediate removal of autoantibody was performed with a good response. The symptoms rapidly disappeared except for the complex partial seizure which persisted until seven years post-SCT.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand. rasrb@mahidol.ac.th
authors.forename: Nongnuch
authors.initials: N
authors.lastname: Sirachainan
authors.forename: Samart
authors.initials: S
authors.lastname: Pakakasama
authors.forename: Suradej
authors.initials: S
authors.lastname: Hongeng
authors.forename: Ampaiwan
authors.initials: A
authors.lastname: Chuansumrit
authors.forename: Lojana
authors.initials: L
authors.lastname: Tuntiyatorn
authors.forename: Soamarat
authors.initials: S
authors.lastname: Vilaiyuk
mesh_terms: D016736:Antiphospholipid Syndrome / Q000209:etiology* / Q000628:therapy*; D002648:Child; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000188:drug therapy; D006446:Hemoglobin E; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D010951:Plasma Exchange; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous; D017086:beta-Thalassemia / Q000628:therapy*
chemical_list: D007166:Immunosuppressive Agents; D006446:Hemoglobin E