title: Effects of lüfukang capsules on coronary artery ligation-induced arrhythmia in dogs.
abstract: OBJECTIVE
  To observe the effects of Lüfukang Capsules on arrhythmia induced by ligation of coronary artery in dogs.
  
  
  METHODS
  Thirty dogs were randomly divided into 5 groups, the model group administrated with equal volume of distilled water, the positive control group administrated with Wenxin Granules, and the small, medium and large dosage LFKC groups, 6 dogs in each group. Thirty minutes after medication, electrocardiogram was conducted and the time of arrhythmia occurrence, times of ventricular premature beat (VP), and incidence rates of ventricular tachycardia (VT) and ventricular fibrillation (VF) were recorded in the model dogs with arrhythmia induced by ligation of coronary artery.
  
  
  RESULTS
  Compared with the model group, the occurrence time of arrhythmia induced by the coronary artery ligation in the medium and large LFKC groups was significantly delayed (20.45 +/- 9.10 and 19.92 +/- 3.78, respectively, both P < 0.05). The frequency of VP in the medium and large LFKC groups was also significantly decreased (8.17 +/- 6.62 and 3.83 +/- 2.79, respectively, both P < 0.01).
  
  
  CONCLUSIONS
  LFKC has anti-arrhythmic effects for the experimental arrhythmia induced by the ligation of coronary artery in dogs.
authors.affiliation: Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan 450002, China. hlhaa@sina.com
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Han
authors.forename: Zhen-Tao
authors.initials: ZT
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.forename: Hui-Chao
authors.initials: HC
authors.lastname: Zhang
authors.forename: Shu-Yin
authors.initials: SY
authors.lastname: Chen
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Long
authors.forename: Hong-Chao
authors.initials: HC
authors.lastname: Shen
authors.forename: Rui-Ru
authors.initials: RR
authors.lastname: Li
authors.forename: Sheng-Wang
authors.initials: SW
authors.lastname: Liang
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D003331:Coronary Vessels / Q000187:drug effects / Q000601:surgery*; D004195:Disease Models, Animal; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008026:Ligation / Q000009:adverse effects; D008297:Male
chemical_list: D000889:Anti-Arrhythmia Agents; D004365:Drugs, Chinese Herbal