title: Vulvar verruciform xanthoma: ten cases associated with lichen sclerosus, lichen planus, or other conditions.
abstract: BACKGROUND
  Verruciform xanthoma (VX) is a rare benign tumor that usually involves the oral cavity. Since the first report of this tumor in 1971, only 9 cases have been reported on the vulva, and 3 of these were associated with another vulvar condition. We describe the clinicopathologic features of 10 patients with vulvar VX and focus on their associated conditions.
  
  
  METHODS
  The mean age of the patients was 68 years (range, 51-80 years). The VX lesions were asymptomatic, yellowish-orange verrucous plaques. The diagnosis was clinically suspected in 2 cases; other suggested diagnoses were condyloma or squamous cell carcinoma. All of the patients had an associated vulvar condition: lichen sclerosus (6 patients), lichen planus (2 patients), Paget disease, or radiodermatitis. Under microscopy, the VX lesions displayed parakeratosis, acanthosis without atypia, and elongated rete ridges. Xanthomatous cells were aggregated in the papillary dermis.
  
  
  CONCLUSIONS
  Vulvar VX is a benign tumor with misleading clinical features. All 10 cases were associated with a vulvar condition, mainly a lichen sclerosus. Therefore, VX might represent a reaction pattern induced by different conditions, mainly characterized by damage to the dermoepidermal junction. When confronted with the diagnosis of vulvar VX, clinicians may look for an associated vulvar condition.
authors.affiliation: Department of Dermatology, Assistance Publique des Hôpitaux de Paris, Hospital Cochin, Paris Descartes University, Paris, France. charlotte.fite@noos.fr
authors.forename: Charlotte
authors.initials: C
authors.lastname: Fite
authors.forename: Françoise
authors.initials: F
authors.lastname: Plantier
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dupin
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Avril
authors.forename: Micheline
authors.initials: M
authors.lastname: Moyal-Barracco
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000150:complications*; D018459:Lichen Sclerosus et Atrophicus / Q000150:complications*; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000150:complications; D011855:Radiodermatitis / Q000150:complications; D014845:Vulvar Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D014846:Vulvar Neoplasms / Q000175:diagnosis; D014860:Warts / Q000175:diagnosis / Q000473:pathology; D014973:Xanthomatosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology