title: Targeting arthropod subolesin/akirin for the development of a universal vaccine for control of vector infestations and pathogen transmission.
abstract: Diseases caused by arthropod-borne pathogens greatly impact on human and animal health. Recent research has provided evidence that tick protective antigens can be used for development of vaccines with the dual target of controlling arthropod infestations and reducing their vector capacity for pathogens. As reviewed herein, protective antigens such as subolesin/akirin, which are highly conserved across vector species, show promise for use in development of a universal vaccine for the control of arthropod infestations and the reduction of pathogen transmission. However, further research is needed in critical areas towards achieving this goal.
authors.affiliation: Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13005 Ciudad Real, Spain. jose delafuente@yahoo.com
authors.forename: José
authors.initials: J
authors.lastname: de la Fuente
authors.forename: Juan A
authors.initials: JA
authors.lastname: Moreno-Cid
authors.forename: Mario
authors.initials: M
authors.lastname: Canales
authors.forename: Margarita
authors.initials: M
authors.lastname: Villar
authors.forename: José M Pérez
authors.initials: JM
authors.lastname: de la Lastra
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Kocan
authors.forename: Ruth C
authors.initials: RC
authors.lastname: Galindo
authors.forename: Consuelo
authors.initials: C
authors.lastname: Almazán
authors.forename: Edmour F
authors.initials: EF
authors.lastname: Blouin
mesh_terms: D000820:Animal Diseases / Q000469:parasitology / Q000517:prevention & control*; D000818:Animals; D000941:Antigens / Q000276:immunology*; D001096:Arachnid Vectors / Q000276:immunology; D060829:Arthropod Proteins / Q000276:immunology*; D006801:Humans; D013984:Tick Infestations / Q000517:prevention & control / Q000662:veterinary*; D013987:Ticks / Q000276:immunology*; D014612:Vaccines
chemical_list: D000941:Antigens; D060829:Arthropod Proteins; D014612:Vaccines; C550207:subolesin, tick