title: The RNA-binding protein Sam68 is a multifunctional player in human cancer.
abstract: Src associated in mitosis, of 68 kDa (Sam68) is a KH domain RNA-binding protein that belongs to the signal transduction and activation of RNA family. Although ubiquitously expressed, Sam68 plays very specialized roles in different cellular environments. In most cells, Sam68 resides in the nucleus and is involved in several steps of mRNA processing, from transcription, to alternative splicing, to nuclear export. In addition, Sam68 translocates to the cytoplasm upon cell stimulation, cell cycle transitions or viral infections, where it takes part to signaling complexes and associates with the mRNA translation machinery. Recent evidence has linked Sam68 function to the onset and progression of endocrine tumors, such as prostate and breast carcinomas. Notably, all the biochemical activities reported for Sam68 seem to be implicated in carcinogenesis. Herein, we review the recent advancement in the knowledge of Sam68 function and regulation and discuss it in the frame of its participation to neoplastic transformation and tumor progression.
authors.affiliation: Department of Public Health and Cell Biology, University of Rome Tor Vergata, Italy.
authors.forename: Pamela
authors.initials: P
authors.lastname: Bielli
authors.forename: Roberta
authors.initials: R
authors.lastname: Busà
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Paronetto
authors.forename: Claudio
authors.initials: C
authors.lastname: Sette
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D012334:RNA, Neoplasm / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; C489559:KHDRBS1 protein, human; D012334:RNA, Neoplasm; D016601:RNA-Binding Proteins