title: Drug resistance pattern of HIV type 1 isolates sampled in 2007 from therapy-naive pregnant women in North-Central Nigeria.
abstract: In Nigeria, the country with the second largest number of HIV-1-infected people globally, antiretroviral therapy rollout is now widespread with an increasing number of individuals and communities benefitting. However, the drug resistance profile of patients initiating or failing on antiretroviral therapy is not well characterized. Here we studied the molecular variability of the protease and reverse transcriptase region of isolates from therapy-naive pregnant women in North-Central Nigeria (one of the geopolitical zones with the highest prevalence of HIV in Nigeria) to identify baseline mutations with potential drug resistance implications. We observed the predominance of CRF02_AG and subtype G in the North-Central Nigerian epidemic and the presence of both primary and secondary drug resistance mutations. Contrary to observation from other geopolitical zones, a decreased frequency of reverse transcriptase mutations/polymorphisms was observed, thus suggesting regional differences in level of transmitted drug resistance that require more study.
authors.affiliation: Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Hannah O
authors.initials: HO
authors.lastname: Ajoge
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Gordon
authors.forename: Sani
authors.initials: S
authors.lastname: Ibrahim
authors.forename: Oladapo S
authors.initials: OS
authors.lastname: Shittu
authors.forename: Thumbi
authors.initials: T
authors.lastname: Ndung'u
authors.forename: Stephen O
authors.initials: SO
authors.lastname: Olonitola
mesh_terms: D016022:Case-Control Studies; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D016333:HIV Protease / Q000187:drug effects / Q000235:genetics*; D054303:HIV Reverse Transcriptase / Q000187:drug effects / Q000235:genetics*; D006679:HIV Seropositivity / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D009549:Nigeria / Q000453:epidemiology; D010802:Phylogeny; D011110:Polymorphism, Genetic; D011247:Pregnancy
chemical_list: D054303:HIV Reverse Transcriptase; D016333:HIV Protease