title: Nanotechnology and chip level systems for pressure driven liquid chromatography and emerging analytical separation techniques: a review.
abstract: Pressure driven liquid chromatography (LC) is a powerful and versatile separation technique particularly suitable for differentiating species present in extremely small quantities. This paper briefly reviews main historical trends and focuses on more recently developed technological approaches in miniaturization and on-chip integration of LC columns. The review emphasizes enabling technologies as well as main technological challenges specific to pressure driven separations and highlights emerging concepts that could ultimately overcome fundamental limitations of conventional LC columns.
authors.affiliation: Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA.
authors.forename: N V
authors.initials: NV
authors.lastname: Lavrik
authors.forename: L T
authors.initials: LT
authors.lastname: Taylor
authors.forename: M J
authors.initials: MJ
authors.lastname: Sepaniak
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods* / Q000639:trends; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000379:methods; D008904:Miniaturization; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D011312:Pressure
chemical_list: D016650:Fluorescein-5-isothiocyanate