title: Optical spectral reflectance of human articular cartilage - relationships with tissue structure, composition and mechanical properties.
abstract: The information from spectral reflectance of articular cartilage has been related to the integrity of the tissue. This study explores more in detail the interrelations between the cartilage composition, structure and mechanical properties, and optical spectral reflectance. Using human osteochondral samples the reflectance spectral images of articular cartilage were captured and analyzed by using CIELAB color space as well as principal component analysis. With both analysis methods statistically significant correlations were observed between the reflectance and histological integrity, as assessed by Mankin scoring, tissue proteoglycan content and dynamic modulus. In thick human cartilage, the reflectance was found to be independent of the cartilage thickness, suggesting negligible influence of the underlying subchondral bone. Based on the present results diagnostically relevant information on cartilage quality can be extracted using optical spectral reflectance measurements. These measurements could be feasible during arthroscopic surgery when more in-depth information of the properties of articular cartilage is needed.
authors.forename: Jussi
authors.initials: J
authors.lastname: Kinnunen
authors.forename: Simo
authors.initials: S
authors.lastname: Saarakkala
authors.forename: Markku
authors.initials: M
authors.lastname: Hauta-Kasari
authors.forename: Pasi
authors.initials: P
authors.lastname: Vahimaa
authors.forename: Jukka S
authors.initials: JS
authors.lastname: Jurvelin