title: Benign lesions in mucosa adjacent to intestinal-type sinonasal adenocarcinoma.
abstract: Occupational exposure to wood dust is a strong risk factor for the development of intestinal-type sinonasal adenocarcinoma (ITAC); however, knowledge on possible precursor lesions or biomarkers is limited. Fifty-one samples of tumor-adjacent mucosa and 19 control samples of mucosa from the unaffected fossa of ITAC patients were evaluated for histological changes and p53 protein expression. Mild dysplasia was observed in 14%, cuboidal metaplasia in 57%, intestinal metaplasia in 8%, squamous metaplasia in 24%, and cylindrocellular hyperplasia in 53% of cases. P53 immunopositivity was generally weak occurring most frequently in squamous metaplasia. Wood dust etiology did not appear of influence on the histological changes, but p53 showed a tendency for higher positivity. Dysplasia adjacent to tumor was indicative of subsequent development of recurrence. In conclusion, precursor lesions do occur in mucosa adjacent to ITAC. This is clinically important, because it may justify the screening of high-risk individuals such as woodworkers.
authors.affiliation: Department of Pathology, Hospital Universitario Central de Asturias, Celestino Villamil s/n, Oviedo, 33006 Asturias, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Vivanco
authors.forename: José Luis
authors.initials: JL
authors.lastname: Llorente
authors.forename: Jhudit
authors.initials: J
authors.lastname: Perez-Escuredo
authors.forename: César
authors.initials: C
authors.lastname: Alvarez Marcos
authors.forename: Manuel Florentino
authors.initials: MF
authors.lastname: Fresno
authors.forename: Mario A
authors.initials: MA
authors.lastname: Hermsen