title: Kinase group protooncogenes in non-hodgkins-lymphomas and nonmalignant lymphoid-tissues - analysis of their expression by insitu hybridization assays.
abstract: Expression of src related proto-oncogenes in non-Hodgkin's lymphomas and non-malignant lymph nodes was analyzed by means of in situ hybridization assays with biotinylated DNA probes. In 36 cases of non-Hodgkin's lymphomas, both c-mos and c-abl were expressed in 27 cases, and c-erbB and c-src were expressed in 15 cases and 7 cases, respectively. No case expressed c-fps or c-yes. On the contrary, in 11 cases of non-malignant lymph nodes c-erbB and c-mos was expressed in only 3 cases. No other proto-oncogenes were expressed. Lymphomas in general express multiple proto-oncogenes simultaneously. A variety of combinations of expressed proto-oncogenes were observed suggesting diversity among non-Hodgkin's lymphomas in biological characteristics. However, a clear association with the expression of a single proto-oncogene or the number of expressed proto-oncogenes with T cell / B cell types, or the histopathological classification of NHL, or disease prognosis was not observed.
authors.affiliation: NAGASAKI UNIV,SCH MED,DEPT ONCOL,12-4 SAKAMOTO MACHI,NAGASAKI 852,JAPAN. RADIAT EFFECTS RES FDN NAGASAKI,NAGASAKI 850,JAPAN. SHIKOKU CANC CTR,MATSUYAMA 790,JAPAN. UNIV TOKYO,INST MED SCI,MINATO KU,TOKYO 108,JAPAN.
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authors.lastname: Sohda
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authors.lastname: Hamatani
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authors.lastname: Abe
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authors.lastname: Kondo
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authors.lastname: Toki
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authors.lastname: Okabe
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authors.lastname: Motoi
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authors.lastname: Ikeda
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authors.lastname: Mori
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authors.lastname: Nakayama
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authors.initials: H
authors.lastname: Shiku