title: Correlation of sex hormone and androgen receptor with diabetes mellitus in elderly men.
abstract: OBJECTIVE
  To investigate sex hormone and androgen receptor (AR) levels and to evaluate their relationship with diabetes mellitus (DM) in senile men.
  
  
  METHODS
  The cross-sectional study included 492 elderly men comprising 104 healthy subjects (mean age 71.4 ± 5.2 years), 259 subjects without DM (71.5 ± 5.0 years) and 129 DM patients (73.0 ± 6.3 years). Plasma concentrations of total testosterone (TT), free testosterone (FT), dehydroepiandrosterone sulphate, sex hormone-binding globulin (SHBG), estradiol (E(2)), luteinising hormone) and follicle-stimulating hormone (FSH) were determined. AR-positive cells were measured by flow cytometry.
  
  
  RESULTS
  TT concentrations were significantly lower in the DM group (13.8 ± 4.7 nmol/l) than in the healthy (17.1 ± 6.1 nmol/l) and non-diabetes groups (15.8 ± 6.0 nmol/l; all P < 0.01). FT, SHBG, AR-positive proportion (AR%) and AR fluorescence intensity showed a decreasing trend among the healthy, non-DM and DM groups, but the differences were not significant. TT, E(2), E(2)/testosterone and SHBG were negatively correlated with blood glucose. SHBG was positively correlated and TT and AR% were negatively correlated with the course of DM. Logistic multiple regression analysis revealed that age, waist/hip ratio, FSH, SHBG and AR% are potential risk factors for DM.
  
  
  CONCLUSIONS
  Low levels of TT, SHBG and AR may be potential risk factors for DM in elderly men.
authors.affiliation: First Geriatric Cardiology Division, Chinese PLA General Hospital, Beijing 100853, P.R. China. calvin301@163.com
authors.forename: Jian
authors.initials: J
authors.lastname: Cao
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Weijun
authors.initials: W
authors.lastname: Hao
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Bingpo
authors.initials: B
authors.lastname: Zhu
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000367:Age Factors; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000032:analysis / Q000378:metabolism; D006801:Humans; D016015:Logistic Models; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D011944:Receptors, Androgen / Q000032:analysis / Q000378:metabolism; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D012739:Gonadal Steroid Hormones; D011944:Receptors, Androgen; D012738:Sex Hormone-Binding Globulin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone