title: No evidence for an association between the rs2824292 variant at chromosome 21q21 and ventricular fibrillation during acute myocardial infarction in a German population.
abstract: BACKGROUND
  In a recently published genome-wide association study (GWAS), three single nucleotide polymorphisms (SNPs) (rs2824292, rs1353342, rs12090554) were significantly associated with increased susceptibility for ventricular fibrillation (VF) during acute myocardial infarction (AMI). The association of rs2824292 could be confirmed in a second cohort. Both cohorts were from the Netherlands. We aimed to replicate this association in a German cohort of AMI patients with or without VF.
  
  
  METHODS
  We included a German cohort of 90 individuals with AMI and VF (cases) and 167 AMI individuals without VF and used Taqman assays for SNP typing.
  
  
  RESULTS
  None of the loci showed evidence for a statistically significant association with VF. The observed genotype frequencies of the three loci were in Hardy-Weinberg equilibrium, which essentially excludes genotyping errors.
  
  
  CONCLUSIONS
  In contrast to the data from the Netherlands, we could not detect a significant association of the rs2824292 locus and risk of VF during AMI in our German cohort. Differences in recruitment and clinical phenotypes between the Dutch and German cohorts may underlie different genotype associations.
authors.affiliation: Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden-Württemberg-Hessen, Mannheim, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Bugert
authors.forename: Elif
authors.initials: E
authors.lastname: Elmas
authors.forename: Ksenija
authors.initials: K
authors.lastname: Stach
authors.forename: Christel
authors.initials: C
authors.lastname: Weiss
authors.forename: Thorsten
authors.initials: T
authors.lastname: Kälsch
authors.forename: Dobromir
authors.initials: D
authors.lastname: Dobrev
authors.forename: Martin
authors.initials: M
authors.lastname: Borggrefe
mesh_terms: D000208:Acute Disease; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014693:Ventricular Fibrillation / Q000150:complications* / Q000235:genetics*