title: Modified Beta-turns in breast carcinoma-associated muc1 related peptides.
abstract: The solution structure of two carcinoma-associated MUC1 core related peptides has been investigated by nuclear magnetic resonance (n.m.r.) spectroscopy. The peptide APDTRPAPG resembles previously studied MUC1 related peptides with a type I beta-turn identified in the region PDTR. This portion of the peptide has previously been identified as the binding site for the monoclonal antibodies HMFG-1 and HMFG-2. The peptide where the D has been replaced by its homologue E, which is selectively recognized by the antibody HMFG-1 but not HMFG-2, appears to have a modified tum region. While amide to amide through space connections are observed the results suggest a more open tum structure.
authors.affiliation: UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND.
authors.forename: M
authors.initials: M
authors.lastname: Scanlon
authors.forename: M
authors.initials: M
authors.lastname: Price
authors.forename: S
authors.initials: S
authors.lastname: Tendler