title: Tgf-Beta-induced apoptosis of transformed fibroblasts by normal fibroblasts - independence of cell-to-cell contact and dependence on reactive oxygen species.
abstract: We studied the elimination of transformed fibroblasts induced by TGF-beta-treated normal fibroblasts. Kinetic experiments revealed two steps: First, the elimination process is induced in the normal cells by TGF-beta and later, the apoptosis of transformed cells is mediated by a short-lived effector different from TGF-beta and TNF. The killing of the transformed cells is directly observable as a cytopathic effect. It does not depend on cell-to-cell contact between normal and transformed cells. Reactive oxygen species (ROS) play an important role in the elimination process but are not the apoptosis-inducing signal transmitted from TGF-beta-treated normal cells.
authors.affiliation: UNIV FREIBURG,INST MED MIKROBIOL & HYG,VIROL ABT,D-79104 FREIBURG,GERMANY.
authors.forename: J
authors.initials: J
authors.lastname: Jurgensmeier
authors.forename: P
authors.initials: P
authors.lastname: Hofler
authors.forename: G
authors.initials: G
authors.lastname: Bauer