title: PERIPHERAL MYELIN PROTEIN-22 IS EXPRESSED IN CNS MYELIN.
abstract: Myelin abnormalities exist in schizophrenia leading to the hypothesis that oligodendrocyte dysfunction plays a role in the pathophysiology of the disease. The expression of the mRNA for the peripheral myelin protein-22 (PMP-22) is decreased in schizophrenia and recent genetic evidence suggests a link between PMP-22 and schizophrenia. While PMP-22 mRNA is found in both rodent and human brain it has been generally thought that no protein expression occurs. Here we show that PMP-22 protein is present in myelin isolated from adult mouse and human brain. These results suggest that PMP-22 protein likely plays a role in the maintenance and function of central nervous system (CNS) myelin and provide an explanation for why altered PMP-22 expression may be pathophysiologically relevant in a CNS disorder such as schizophrenia.
authors.affiliation: Research and Development, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA.
authors.forename: Rita
authors.initials: R
authors.lastname: De Gasperi
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Gama Sosa
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Naumowicz
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Hof
authors.forename: Lucia
authors.initials: L
authors.lastname: Notterpek
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Davis
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Buxbaum
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Elder