title: Differential pulse anodic voltammetric determination of tiapride hydrochloride in pharmaceutical preparation and human urine using carbon paste electrodes.
abstract: The anodic voltammetric behavior of tiapride hydrochloride (TiapCl) was studied at carbon paste electrodes in 0.04 M Britton-Robinson buffer pH 7.0 using cyclic and differential pulse voltammetric techniques. The oxidation of TiapCl is an irreversible diffusion-controlled process. A differential pulse anodic voltammetric procedure has been developed for determination of the drug over the concentration range 0.36 - 19.35 µg/ml with detection and quantification limits of 0.12 and 0.40 µg/ml, respectively. The proposed method was successfully applied for the determination of the drug in commercial tablets and in spiked human urine samples.
authors.affiliation: Faculty of Industrial Education, Beni Suef University, Egypt. sayed_imai@yahoo.com
authors.forename: S I M
authors.initials: SI
authors.lastname: Zayed
mesh_terms: D002244:Carbon / Q000737:chemistry*; D004563:Electrochemistry; D004566:Electrodes; D006801:Humans; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012016:Reference Values; D012680:Sensitivity and Specificity; D013976:Tiapamil Hydrochloride / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations; D002244:Carbon; D013976:Tiapamil Hydrochloride