title: Experimental infection of Japanese encephalitis virus in dogs.
abstract: A previous serosurvey of Japanese encephalitis virus (JEV) among dogs suggested that dogs are well suited for use as sentinels for assessing the risk of JEV transmission to humans. To examine the clinical symptoms and duration of anti-JEV antibodies in dogs, three dogs were experimentally challenged with JEV. All JEV-infected dogs did not show any clinical signs or abnormal blood tests, except for C-reactive protein. Virus-neutralization titers rapidly increased and were maintained until 70 days postinfection, and neither the virus nor the viral genome was detected in blood. Thus, since dogs live in close proximity to humans as companion animals, they are well suited for use as sentinels for surveying the human risk of JEV infection.
authors.affiliation: Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimoda
authors.forename: Seiji
authors.initials: S
authors.lastname: Tamaru
authors.forename: Masahiro
authors.initials: M
authors.lastname: Morimoto
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Hayashi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shimojima
authors.forename: Ken
authors.initials: K
authors.lastname: Maeda
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D004283:Dog Diseases / Q000097:blood / Q000821:virology*; D004285:Dogs; D004664:Encephalitis Virus, Japanese; D004672:Encephalitis, Japanese / Q000097:blood / Q000662:veterinary* / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D002097:C-Reactive Protein