title: Alternating hemiplegia of childhood: successful treatment with topiramate and flunarizine, a case report.
abstract: Alternating hemiplegia of childhood (AHC) is a rare neurological disorder which usually presents before 18 months of age and is characterised by recurrent alternating episodes of hemiparesis. A single effective treatment for this condition is yet to be established; flunarizine is currently the most widely used but with varying degrees of success. An 18-month-old child presented with AHC and treatment with a combination of topiramate and flunarizine made a significant difference in controlling the frequency and severity of the attacks. This possibly allowed a better developmental outcome than in most children with this condition. Topiramate combined with flunarizine for treating AHC has much potential for further research.
authors.affiliation: Department of Paediatrics, National University Hospital, Singapore. ramkumar.aishworiya@mohh.com.sg
authors.forename: R
authors.initials: R
authors.lastname: Aishworiya
authors.forename: P S
authors.initials: PS
authors.lastname: Low
authors.forename: S K H
authors.initials: SK
authors.lastname: Tay
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage*; D005444:Flunarizine / Q000008:administration & dosage*; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006429:Hemiplegia / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008297:Male; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose; D005444:Flunarizine