title: The 1287 G/A polymorphism of the norepinephrine transporter gene (NET) is involved in commission errors in Korean children with attention deficit hyperactivity disorder.
abstract: BACKGROUND
  Previous evidence supports the role of noradrenergic systems in ADHD, and norepinephrine transporter (NET) is critical in regulating the noradrenergic system. The present study aimed to investigate the association between NET gene polymorphism and the performance measures of the Continuous Performance Test (CPT) in Korean ADHD children.
  
  
  METHODS
  Eighty-seven children (mean age = 9.23 ± 1.99 years) with ADHD were recruited from a university hospital. Genotypes of G1287A of the NET gene (SLC6A2) were analyzed. All participants completed the CPT, with performance measures of omission errors, commission errors, reaction time and reaction standardization computed. The relationship between G1287A polymorphisms and CPT performance measures was examined.
  
  
  RESULTS
  There were 46 subjects with the G/G genotype, 35 subjects with the G/A genotype and 6 subjects with the A/A genotype. Among the three groups, there were no significant differences in the performance of CPTs. When dichotomized according to whether the subjects have the rare allele or not, subjects with the homozygous G/G genotype showed significantly lower commission errors compared to those without G/G genotypes (by independent T-test, t = -2.18, p = 0.026).
  
  
  CONCLUSIONS
  Our study found a significant association between commission errors of the CPT and the G1287A genotype of the NET gene in Korean ADHD children. These findings suggest a protective role of the G/G genotype of the NET polymorphisms in the deficits of response inhibition in ADHD children.
authors.affiliation: Department of Child and Adolescent Psychiatry and Institute of Behavioral Science in Medicine, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Dong-Ho
authors.initials: DH
authors.lastname: Song
authors.forename: Kyungun
authors.initials: K
authors.lastname: Jhung
authors.forename: Jungeun
authors.initials: J
authors.lastname: Song
authors.forename: Keun-Ah
authors.initials: KA
authors.lastname: Cheon
mesh_terms: D000293:Adolescent; D000483:Alleles; D044466:Asian People / Q000235:genetics* / Q000523:psychology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000523:psychology*; D002648:Child; D005838:Genotype; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000235:genetics / Q000502:physiology; D012720:Severity of Illness Index
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins