title: Chronotoxicity as related to chronobiology.
abstract: This review focuses primarily on the complexities of chronotoxicity and chronopharmacology (time-of-day effects on the metabolism of environmental chemicals and therapeutic agents as related to chronobiology). The nature of the melatonin signal may modify the function of the hepatic endoplasmic reticulum resulting in variations in the metabolism of xenobiotic chemicals. Concepts are explored for modification of exposure limits and/or Threshold Limit Values (TLVs) of industrial chemicals in risk assessment and health effects of workers on rotating shifts. The TLVs of chemicals may be changed during work shift schedules to minimize adverse health effects among workers.
authors.forename: M S
authors.initials: MS
authors.lastname: Dhami
authors.forename: M
authors.initials: M
authors.lastname: Menon
authors.forename: D V
authors.initials: DV
authors.lastname: Parke
authors.forename: M F
authors.initials: MF
authors.lastname: Dhami
authors.forename: M
authors.initials: M
authors.lastname: Afzal
mesh_terms: D002909:Chronobiology Phenomena / Q000187:drug effects*; D006801:Humans; D008550:Melatonin / Q000378:metabolism; D016273:Occupational Exposure; D016272:Occupational Health; D018570:Risk Assessment; D020711:Threshold Limit Values; D014940:Work Schedule Tolerance; D015262:Xenobiotics / Q000008:administration & dosage* / Q000009:adverse effects* / Q000378:metabolism
chemical_list: D015262:Xenobiotics; D008550:Melatonin