title: Survival of a cohort of women with cervical cancer diagnosed in a Brazilian cancer center.
abstract: OBJECTIVE
  To assess overall survival of women with cervical cancer and describe prognostic factors associated.
  
  
  METHODS
  A total of 3,341 cases of invasive cervical cancer diagnosed at the Brazilian Cancer Institute, Rio de Janeiro, southeastern Brazil, between 1999 and 2004 were selected. Clinical and pathological characteristics and follow-up data were collected. There were performed a survival analysis using Kaplan-Meier curves and a multivariate analysis through Cox model.
  
  
  RESULTS
  Of all cases analyzed, 68.3% had locally advanced disease at the time of diagnosis. The 5-year overall survival was 48%. After multivariate analysis, tumor staging at diagnosis was the single variable significantly associated with prognosis (p<0.001). There was seen a dose-response relationship between mortality and clinical staging, ranging from 27.8 to 749.6 per 1,000 cases-year in women stage I and IV, respectively.
  
  
  CONCLUSIONS
  The study showed that early detection through prevention programs is crucial to increase cervical cancer survival.
authors.affiliation: Serviço de Oncologia Clínica, Hospital do Câncer II, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil. ccarmo@inca.gov.br
authors.forename: Claudio Calazan de
authors.initials: CC
authors.lastname: Carmo
authors.forename: Ronir Raggio
authors.initials: RR
authors.lastname: Luiz
mesh_terms: D000328:Adult; D017677:Age Distribution; D001938:Brazil / Q000453:epidemiology; D016009:Chi-Square Distribution; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012959:Socioeconomic Factors; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000401:mortality*