title: Role of serotonergic-related systems in suicidal behavior: Data from a case-control association study.
abstract: OBJECTIVE
  To investigate whether functional polymorphisms directly (HTR2A and SLC6A4 genes) or indirectly (IL-1 gene complex, APOE and ACE genes) related with serotonergic neurotransmission were associated with suicidal behavior.
  
  
  METHODS
  227 suicide attempters, 686 non-suicidal psychiatric patients, and 420 healthy controls from a homogeneous Spanish Caucasian population were genotyped using standard methods.
  
  
  RESULTS
  There were no differences in genotype frequencies between the three groups. The -1438A/G [χ(2) (df)=9.80 (2), uncorrected p=0.007] and IL-1α -889C/T [χ(2) (df)=8.76 (2), uncorrected p=0.013] genotype frequencies between impulsive and planned suicide attempts trended toward being different (not significant after Bonferroni correction). Suicide attempts were more often impulsive in the presence of -1438G/G or IL-1α -889C/T or C/C genotypes. There was interaction between the polymorphism 5-HTTLPR and age [LRT (df)=6.84 (2), p=0.033] and between the polymorphisms APOE and IL-1RA (86bp)(n) [LRT (df)=12.21 (4), p=0.016] in relation to suicide attempt lethality.
  
  
  CONCLUSIONS
  These findings further evidence the complexity of the association between genetics and suicidal behavior, the need to study homogenous forms of the behavior and the relevance of impulsive and aggressive traits as endophenotypes for suicidal behavior.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Julián Clavería 6-3°, 33006 Oviedo, Spain. frank@uniovi.es
authors.forename: Pilar A
authors.initials: PA
authors.lastname: Saiz
authors.forename: Paz
authors.initials: P
authors.lastname: García-Portilla
authors.forename: Begoña
authors.initials: B
authors.lastname: Paredes
authors.forename: Paul
authors.initials: P
authors.lastname: Corcoran
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
authors.forename: Blanca
authors.initials: B
authors.lastname: Morales
authors.forename: Emilio
authors.initials: E
authors.lastname: Sotomayor
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.forename: Gerardo
authors.initials: G
authors.lastname: Flórez
authors.forename: María-Teresa
authors.initials: MT
authors.lastname: Bascaran
authors.forename: Manuel
authors.initials: M
authors.lastname: Bousoño
authors.forename: Julio
authors.initials: J
authors.lastname: Bobes
mesh_terms: D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D058068:Endophenotypes; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000523:psychology; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D001523:Mental Disorders / Q000235:genetics* / Q000523:psychology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics; D012701:Serotonin / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data; D009435:Synaptic Transmission / Q000235:genetics*; D044465:White People / Q000235:genetics / Q000523:psychology
chemical_list: D001057:Apolipoproteins E; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D044402:Receptor, Serotonin, 5-HT2A; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A