title: Delineation of chondroid lipoma: an immunohistochemical and molecular biological analysis.
abstract: Aims. Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocation t(11;16). Here, we analyze CL and its histological mimics. Methods. CL (n = 4) was compared to a variety of histological mimics (n = 83) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis, CCND1 and FUS were investigated as potential translocation partners. Results. All CLs were strongly positive for CCND1. One of 4 myoepitheliomas, CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas, CCND1 was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement of CCND1 and FUS as translocation partners. Conclusions. Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.
authors.affiliation: Department of Surgical Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX, Amsterdam, The Netherlands.
authors.forename: Ronald S A
authors.initials: RS
authors.lastname: de Vreeze
authors.forename: Frits
authors.initials: F
authors.lastname: van Coevorden
authors.forename: Lucie
authors.initials: L
authors.lastname: Boerrigter
authors.forename: Petra M
authors.initials: PM
authors.lastname: Nederlof
authors.forename: Rick L
authors.initials: RL
authors.lastname: Haas
authors.forename: Johannes
authors.initials: J
authors.lastname: Bras
authors.forename: Andreas
authors.initials: A
authors.lastname: Rosenwald
authors.forename: Thomas
authors.initials: T
authors.lastname: Mentzel
authors.forename: Daphne
authors.initials: D
authors.lastname: de Jong