title: [Preventive and therapeutic effects of quercetin on hyperuricemia and renal injury in rats].
abstract: OBJECTIVE
  To study the preventive and therapeutic effects of Quercetin (Que) on hyperuricemia and renal failure in rats.
  
  
  METHODS
  Seventy rats were divided into ten groups, normal control group, model control group, allopurinol group and seven Que groups (50, 40, 30, 20, 10, 5 and 2.5 mg/kg). Hyperuricemia and renal failure in rats were induced by adenine and ethambutol hydrochloride intragastrically, and then Que was given for 3 weeks. The items related to high serum uric acid and renal injury were observed.
  
  
  RESULTS
  Levels of serum uric acid (SUA), serum urea nitrogen ( SUN), serum creatinine (SCr), malonaldehyde (MDA) and the activity of xanthine oxidase (XOD) in liver were lowered effectively by Que, and the activity of superoxide dismutase (SOD) in serum was increased. The better results of lowering serum uric acid and protecting against renal failure were at the dosage of Que between 10 and 20 mg/kg.
  
  
  CONCLUSIONS
  Hyperuricemia and renal failure in rats could be intervened by Que. The possible mechanism might be inhibiting the activity of liver XOD and improving the ability of clearing oxygen free radicals and reducing lipid peroxidation, which might play an important role in reducing serum uric acid level and protecting kidney.
authors.affiliation: College of Public Health, Zhengzhou University,Zhengzhou 450001, China. yaofang7293@126.com
authors.forename: Fangfang
authors.initials: F
authors.lastname: Yao
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Fu
authors.forename: Wei
authors.initials: W
authors.lastname: He
mesh_terms: D000225:Adenine; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004977:Ethambutol; D033461:Hyperuricemia / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D007674:Kidney Diseases / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D008297:Male; D020011:Protective Agents / Q000494:pharmacology; D011794:Quercetin / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D004977:Ethambutol; D011794:Quercetin; D003404:Creatinine; D014969:Xanthine Oxidase; D000225:Adenine