title: NK cell recognition and killing of melanoma cells is controlled by multiple activating receptor-ligand interactions.
abstract: The role of natural killer (NK) cells in tumor immunosurveillance has been recently underlined. A better understanding of the receptor-ligand interactions between NK cells and solid tumor cells is essential for introducing more effective NK cell-based immunotherapy protocols into clinical practice. We previously analyzed the surface expression of ligands for NK cell-activating receptors and costimulatory molecules in a large panel of melanoma cell lines. Although the expression of ligands for NK cell-activating receptors is variable, the majority of melanoma cell lines express ligands for NKG2D and for DNAX accessory molecule-1 (DNAM-1). While the NKG2D receptor has been described as the principal entity responsible for the lysis of several melanoma cell lines, the role of natural cytotoxicity receptors (NCRs) and DNAM-1 receptors in NK cell recognition and killing of melanoma cells has been recently emphasized. Antibody-mediated masking of NKG2D, NCRs, and DNAM-1 has proven that NKG2D, NCRs, and DNAM-1 frequently cooperate in the lysis of melanoma cells. In this work, we provide an overview of recent advances in the study of melanoma cells' susceptibility to NK cell-mediated lysis and how multiple receptor-ligand interactions participate in melanoma cell elimination.
authors.affiliation: Immunology Unit, Department of Physiology, University of Extremadura, Cáceres, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Morgado
authors.forename: Beatriz
authors.initials: B
authors.lastname: Sanchez-Correa
authors.forename: Javier G
authors.initials: JG
authors.lastname: Casado
authors.forename: Esther
authors.initials: E
authors.lastname: Duran
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Gayoso
authors.forename: Fernando
authors.initials: F
authors.lastname: Labella
authors.forename: Rafael
authors.initials: R
authors.lastname: Solana
authors.forename: Raquel
authors.initials: R
authors.lastname: Tarazona
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D008024:Ligands; D008545:Melanoma / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000378:metabolism; D055607:Receptors, Natural Killer Cell / Q000378:metabolism*; D000098862:T Lineage-Specific Activation Antigen 1
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D000098862:T Lineage-Specific Activation Antigen 1; C527085:KLRK1 protein, human; D008024:Ligands; D055655:NK Cell Lectin-Like Receptor Subfamily K; D055607:Receptors, Natural Killer Cell