title: Transformation of murine fibroblasts by uv-light and tgf-Beta - establishment of an autocrine tgf-Beta loop.
abstract: Murine fibroblasts stably transformed by initiation with UV light and tumor promotion with TGF-beta form colonies in soft agar, exhibit a diffuse actin pattern and induce angiogenesis. They differ from their parental cells by their ability to release active TGF and to react to TGF-beta by increased colony formation. Antibodies directed against TGF-beta abrogate the transformed phenotype, indicating the action of an autocrine TGF-beta loop for the maintenance of the transformed state. However, TGF-beta which is responsible for the maintenance of the transformed state, proves to be a severe obstacle for the survival of transformed cells which are cocultivated with normal cells.
authors.affiliation: UNIV FREIBURG,INST MED MIKROBIOL & HYG,VIROL ABT,D-79104 FREIBURG,GERMANY.
authors.forename: I
authors.initials: I
authors.lastname: Wehrle
authors.forename: A
authors.initials: A
authors.lastname: Jakob
authors.forename: P
authors.initials: P
authors.lastname: Hofler
authors.forename: G
authors.initials: G
authors.lastname: Bauer