title: [Inheritance and expression stability of transgene in transgenic animals].
abstract: Transgenic technology is one of the most hotspots in biology. In the past decade, the progress in animal cloning has provided an alternative method to improve transgenic efficiency. Many kinds of transgenic animals have been successfully produced via the combination of transfection and nuclear transfer. However, the ultimate aim of transgenesis is not to produce several transgenic animals, but to service for the needs of human. In animal production, transgenic technology has been used to breed new livestock, which has received a lot of attention in China. It has been evidenced that inheritance and expression instability of transgene in transgenic animals is still the major limitation, which is attributed to position effect, epigenetic modification, and hereditary efficiency of transgene. In this review, we discussed the three points for promoting the industrialization of animal transgenic breeding.
authors.affiliation: College of Life Science, Northeast Agricultural University of China, Harbin 150030, China. kqr1982@yahoo.com.cn
authors.forename: Qing-Ran
authors.initials: QR
authors.lastname: Kong
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Liu
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics*; D015870:Gene Expression; D019076:Transgenes