title: Pleomorphic type of malignant fibrous histiocytoma with myxoid stroma of the vulva in a young woman.
abstract: Malignant fibrous histiocytoma (MFH) of the vulva is extremely rare; to date, there have been nine case reports. Almost all of these cases involved middle-aged women. We encountered a 21-year-old woman with a 4.5 × 2.6 cm superficial, localized, exophytic tumor of the right vulva. Microscopic findings on punch biopsy of the tumor initially suggested a vulvar sarcoma. The patient underwent wide local excision of the vulva. The extirpated specimen demonstrated the pleomorphic type of MFH with myxoid stroma of the vulva. The clinical stage was found to be IIB, based on the American Joint Committee on Cancer staging system. Chromosomal analysis of the tumor using the conventional G-band method was normal (46XX). This seems to be a very rare case of MFH of the vulva in a young woman. Physicians should therefore include MFH in the differential diagnosis of vulvar tumors, even though it is a rare disease.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Sakuragaoka, Kagoshima, Japan.
authors.forename: Tokiko
authors.initials: T
authors.lastname: Iwakawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuji
authors.forename: Tomonori
authors.initials: T
authors.lastname: Hamada
authors.forename: Masaki
authors.initials: M
authors.lastname: Kamio
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuo
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Yoshinaga
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kitajima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Douchi
mesh_terms: D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000473:pathology* / Q000601:surgery; D006801:Humans; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery; D055815:Young Adult