title: Inhibition of Feline leukemia virus replication by the integrase inhibitor Raltegravir.
abstract: The oncogenic gammaretrovirus Feline leukemia virus (FeLV) has been the leading cause of death among domestic cats until the introduction of efficient diagnostics and vaccines in the late 1980s. So far, no efficient treatment for viremic animals is available. Hence, use of the FeLV model to evaluate antiretroviral therapies applied to HIV is a timely task. The efficacy of the integrase inhibitor Raltegravir, which is widely used for the treatment of HIV in humans, has been assessed in vitro for the FeLV-A/Glasgow-1 strain. EC(50) values for FeLV-A inhibition in feline cell lines are in the range of that observed for HIV and xenotropic murine leukemia virus-related gammaretrovirus. Therefore, Raltegravir may be a potential therapeutical agent for felids with progressive FeLV infection.
authors.affiliation: Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH - 8057 Zurich, Switzerland. vcattori@vetclinics.uzh.ch
authors.forename: Valentino
authors.initials: V
authors.lastname: Cattori
authors.forename: Beatrice
authors.initials: B
authors.lastname: Weibel
authors.forename: Hans
authors.initials: H
authors.lastname: Lutz
mesh_terms: D000818:Animals; D017209:Apoptosis; D002415:Cats; D002460:Cell Line; D002470:Cell Survival; D019429:Integrase Inhibitors / Q000494:pharmacology*; D005256:Leukemia Virus, Feline / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D011760:Pyrrolidinones / Q000494:pharmacology*; D000068898:Raltegravir Potassium; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D019429:Integrase Inhibitors; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium