title: AKAP phosphatase complexes in the heart.
abstract: Directed protein phosphorylation is indisputably critical for a multitude of cellular processes. A growing body of research demonstrates A kinase anchoring proteins (AKAPs) to mediate a significant number of phosphorylation events in the heart. By acting as molecular tethers for the regulatory subunit of protein kinase A, AKAPs focus kinase activity onto specific substrate. In the time since their discovery, the AKAP model has evolved in appreciation of the broader role these scaffolds play in coordinating multiple signaling enzymes to efficiently regulate dynamic cellular processes. The focus of this review is on the emerging role of AKAPs in regulating the 3 main cardiac phosphatases: Protein Phosphatase 1 by AKAP18 and Yotiao, and Protein Phosphatases 2A and 2B by muscle specific A-kinase anchoring protein.
authors.affiliation: Department of Cell Biology, Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06030, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Redden
authors.forename: Kimberly L
authors.initials: KL
authors.lastname: Dodge-Kafka
mesh_terms: D054758:A Kinase Anchor Proteins / Q000378:metabolism*; D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism; D006321:Heart / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D010766:Phosphorylation / Q000502:physiology; D054645:Protein Phosphatase 1 / Q000378:metabolism*; D054648:Protein Phosphatase 2 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D054758:A Kinase Anchor Proteins; C112596:AKAP7 protein, human; C119719:AKAP9 protein, human; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D019703:Calcineurin; D054645:Protein Phosphatase 1; D054648:Protein Phosphatase 2