title: Diagnosis and treatment of differentiated thyroid carcinoma.
abstract: Thyroid cancer is the most common endocrine malignancy. Historically, the diagnosis has been made via fine-needle aspiration cytology; however, molecular marker analysis, particularly in indeterminate specimens, is beginning to play a more prominent role. Once the diagnosis of thyroid cancer is established, patients should undergo preoperative ultrasound evaluation followed by appropriate surgical resection, radioiodine ablation, and thyrotropin suppression. After the initial treatment, patients must be monitored regularly for recurrent disease utilizing clinical examination, thyroglobulin measurement, and radiological imaging.
authors.affiliation: Division of Endocrinology and Metabolism, University of Pittsburgh Medical Center, 200 Lothrop Street, E 1140 BST, Pittsburgh, PA 15261, USA.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Cox
authors.forename: Shane O
authors.initials: SO
authors.lastname: LeBeau
mesh_terms: D015415:Biomarkers / Q000032:analysis; D044963:Biopsy, Fine-Needle; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D009367:Neoplasm Staging; D018570:Risk Assessment; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D013965:Thyroidectomy; D013972:Thyrotropin / Q000037:antagonists & inhibitors; D018084:Ultrasonography, Interventional
chemical_list: D015415:Biomarkers; D007457:Iodine Radioisotopes; D013972:Thyrotropin