title: Detecting metabolic activities of bacteria using a simple carbon nanotube device for high-throughput screening of anti-bacterial drugs.
abstract: In this contribution, we demonstrate a simple carbon nanotube device to electrically detect the presence of bacteria (Escherichai coli) with high sensitivity (<100 cfu/mL) and the glucose triggered metabolic activities of bacteria in real-time. As proof-of-concept demonstration, we also show that this nanoelectronic approach can be employed for high-throughput screening of anti-bacterial drugs.
authors.affiliation: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
authors.forename: Yinxi
authors.initials: Y
authors.lastname: Huang
authors.forename: Herry Gunadi
authors.initials: HG
authors.lastname: Sudibya
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D048168:Escherichia coli K12 / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D057166:High-Throughput Screening Assays / Q000295:instrumentation / Q000379:methods; D008826:Microbial Sensitivity Tests / Q000295:instrumentation / Q000379:methods; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000648:ultrastructure; D012680:Sensitivity and Specificity
chemical_list: D000900:Anti-Bacterial Agents; D037742:Nanotubes, Carbon; D005947:Glucose