title: Generation of novel nucleases with extended specificity by rational and combinatorial strategies.
authors.affiliation: Justus-Liebig-Universitaet Giessen, Institut für Biochemie, Giessen, Germany.
authors.forename: Alfred
authors.initials: A
authors.lastname: Pingoud
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wende
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004247:DNA / Q000378:metabolism; D053837:DNA Cleavage; D004720:Endonucleases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015202:Protein Engineering; D013379:Substrate Specificity
chemical_list: D004247:DNA; D004720:Endonucleases