title: Delayed contrast enhanced MRI of meniscus with ionic and non-ionic agents.
abstract: OBJECTIVE
  To evaluate the potential difference in post-contrast T(1) relaxation time of the meniscus (T(1Gd)) between osteoarthritic patients (OA) and healthy subjects (HS), and to verify if charge density has any influence on meniscal T(1Gd).
  
  
  METHODS
  We performed a retrospective analysis of meniscal T(1) relaxation time on data previously acquired for studying articular cartilage with both ionic and non-ionic contrast media. MR imaging was performed in 10 OA and 8 HS at 120 min following administration of double-dose ionic Gd-DTPA(2-) on one day and non-ionic Gd-DTPA-BMA on a different day. A three-dimensional Look-Locker sequence with echo time of 2 ms was used for data acquisition to allow T(1) mapping of the meniscus.
  
  
  RESULTS
  Compared with HS, significantly lower meniscal T(1Gd) was observed in OA with either ionic Gd-DTPA(2-) (P < 0.01) or non-ionic Gd-DTPA-BMA (P < 0.001) contrast agent. There was a correlation between meniscal T(1) (Gd-DTPA(2-)) versus T(1) (Gd-DTPA-BMA). Meniscal T(1) (Gd-DTPA-BMA) showed a larger difference and smaller overlap between OA and HS. No significant differences in either pre-contrast T(1) or post-contrast T(1Gd) were observed between inner and outer zones of the meniscus with either agent.
  
  
  CONCLUSIONS
  Significant differences in meniscal T(1Gd) between OA and HS were observed with both ionic and non-ionic contrast agents, suggesting that charge density is not responsible for the observed differences.
authors.affiliation: Department of Radiology, NorthShore University HealthSystem, Evanston, Illinois, USA. wli@northshore.org
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Robert R
authors.initials: RR
authors.lastname: Edelman
authors.forename: Pottumarthi V
authors.initials: PV
authors.lastname: Prasad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003287:Contrast Media / Q000494:pharmacology; D005260:Female; D019786:Gadolinium DTPA / Q000494:pharmacology; D006801:Humans; D007477:Ions; D007717:Knee / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D007477:Ions; D019786:Gadolinium DTPA