title: Marjolin ulcer: an overlooked entity.
abstract: Marjolin ulcer is a well-defined, but uncommon malignant ulcer that occurs in chronic wounds and cutaneous scars. Jean-Nicolas Marjolin was credited with describing this phenomenon in 1828. This entity is frequently overlooked and therefore inadequately treated leading to a poor prognosis. The malignant transformation of an ulcer is most commonly associated with burn scars, but has been reported in many other types of chronic, non healing wounds such as traumatic wounds, venous stasis and chronic pressure ulcers, fistulas, lacerations and leprosy ulcers. Development of malignancy tends to be slow with an average time of approximately 25 years. Various theories concerning pathogenesis of Marjolin ulcer have been proposed. Well-differentiated squamous cell carcinoma (SCC) is the most common histological type of Marjolin ulcer. Biopsy with histopathologic interpretation remains the gold standard for the diagnosis, with radical surgical excision being the treatment of choice. A high index of suspicion should be held by any health care provider when evaluating a chronic, non healing wound. This is a case report of a Marjolin ulcer arising on the left buttock of a patient with a long-standing history of a traumatic wound.
authors.affiliation: Department of Pathology, College of Medicine, University of Illinois, Chicago, IL 60612, USA. spavlo2@uic.edu
authors.forename: Sasha
authors.initials: S
authors.lastname: Pavlovic
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Wiley
authors.forename: Grace
authors.initials: G
authors.lastname: Guzman
authors.forename: David
authors.initials: D
authors.lastname: Morris
authors.forename: Marylee
authors.initials: M
authors.lastname: Braniecki
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D012883:Skin Ulcer / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D014947:Wounds and Injuries / Q000150:complications* / Q000175:diagnosis