title: Synergistic toxic effect of nano-Al2O3 and As(V) on Ceriodaphnia dubia.
abstract: Engineered nanomaterials (ENMs) alone could negatively impact the environment and human health. However, their role in the presence of other toxic substances is not well understood. The toxicity of nano-Al(2)O(3), inorganic As(V), and a combination of both was examined with C. dubia as the model organisms. Bare nano-Al(2)O(3) particles exhibited partial mortality at concentrations of greater than 200mg/L. When As(V) was also present, a significant amount of As(V) was accumulated on the nano-Al(2)O(3) surface, and the calculated LC(50) of As(V) in the presence of nano-Al(2)O(3) was lower than that it was without the nano-Al(2)O(3). The adsorption of As(V) on the nano-Al(2)O(3) surface and the uptake of nano-Al(2)O(3) by C. dubia were both verified. Therefore, the uptake of As(V)-loaded nano-Al(2)O(3) was a major reason for the enhanced toxic effect.
authors.affiliation: Department of Civil, Architectural and Environmental Engineering, Missouri University of Science and Technology, Rolla, MO 65409, USA.
authors.forename: Demin
authors.initials: D
authors.lastname: Wang
authors.forename: Ji
authors.initials: J
authors.lastname: Hu
authors.forename: Brett E
authors.initials: BE
authors.lastname: Forthaus
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wang
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D001149:Arsenates / Q000737:chemistry / Q000633:toxicity*; D003621:Daphnia / Q000187:drug effects*; D004357:Drug Synergism; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity*
chemical_list: D001149:Arsenates; D014874:Water Pollutants, Chemical; D000537:Aluminum Oxide