title: Differential effects of cold exposure on gene expression profiles in white versus brown adipose tissue.
abstract: The thermogenic function of brown adipose tissue (BAT) is known to be markedly elevated when animals are exposed to the cold, and intensive studies have been carried out to understand the molecular basis enabling effective thermogenesis in cold-exposed animals. In this study, we used microarray analysis to examine the effects of cold exposure of animals on their gene expression profiles in white adipose tissue (WAT), which seems to function as a counterpart tissue of BAT. The results indicate that the effects of cold exposure on the gene expression profiles of WAT were much more moderate than the effects on those of BAT. Possible reasons for the different responses of BAT and WAT to cold exposure are discussed.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi-1, Tokushima 770-8505, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Watanabe
authors.forename: Takenori
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Eriko
authors.initials: E
authors.lastname: Obana
authors.forename: Kanami
authors.initials: K
authors.lastname: Niiyama
authors.forename: Takuya
authors.initials: T
authors.lastname: Hada
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ooie
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kataoka
authors.forename: Tomoshige
authors.initials: T
authors.lastname: Hori
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Houchi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shinohara
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism*; D000818:Animals; D015152:Blotting, Northern; D003080:Cold Temperature; D004734:Energy Metabolism / Q000235:genetics*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D022722:Thermogenesis / Q000235:genetics*
chemical_list: D024101:Mitochondrial Proteins