title: Trihexyphenidyl hydro-chloride: a powder diffraction study.
abstract: IN THE CATION OF THE TITLE COMPOUND [SYSTEMATIC NAME: 1-(3-cyclo-hexyl-3-hy-droxy-3-phenyl-prop-yl)piperidinium chloride], C(20)H(32)NO(+)·Cl(-), the cyclo-hexyl and piperidine rings are in chair conformations. In the crystal structure, cations and anions are linked into chains along the c-axis direction via O-H⋯Cl and N-H⋯Cl hydrogen bonds. Weak inter-molecular C-H⋯Cl inter-actions link further these chains into layers parallel to the bc plane. The salt, obtained from a racemic solution, was found to crystallize in the chiral P2(1)2(1)2 space group, indicating that, in the absence of any evident chirality-inducing process, the polycrystalline powders consist of an equivalent mixture of R and S enanti-omers, forming a racemic conglomerate.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Maccaroni
authors.forename: Luciana
authors.initials: L
authors.lastname: Malpezzi
authors.forename: Norberto
authors.initials: N
authors.lastname: Masciocchi