title: ADH1 expression inversely correlates with CDR1 and CDR2 in Candida albicans from chronic oral candidosis in APECED (APS-I) patients.
abstract: Expression of the alcohol dehydrogenase gene ADH1, which converts ethanol into carcinogenic acetaldehyde, significantly inversely correlated with the expression of CDR1 and CDR2, genes linked to azole resistance in Candida albicans isolated from chronic oral candidosis in autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy (APECED, APS-I) patients. This is a novel link between candidal two-carbon metabolism genes and azole resistance.
authors.affiliation: Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland. emilia.siikala@helsinki.fi
authors.forename: Emilia
authors.initials: E
authors.lastname: Siikala
authors.forename: Paul
authors.initials: P
authors.lastname: Bowyer
authors.forename: Malcolm
authors.initials: M
authors.lastname: Richardson
authors.forename: Harri
authors.initials: H
authors.lastname: Saxen
authors.forename: Dominique
authors.initials: D
authors.lastname: Sanglard
authors.forename: Riina
authors.initials: R
authors.lastname: Rautemaa
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism; D000426:Alcohol Dehydrogenase / Q000096:biosynthesis*; D000438:Alcohols / Q000378:metabolism; D000935:Antifungal Agents / Q000378:metabolism; D001393:Azoles / Q000378:metabolism; D002176:Candida albicans / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D002180:Candidiasis, Oral / Q000382:microbiology*; D002273:Carcinogens / Q000378:metabolism; D002908:Chronic Disease; D005656:Fungal Proteins / Q000096:biosynthesis*; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D016884:Polyendocrinopathies, Autoimmune / Q000382:microbiology*
chemical_list: D000438:Alcohols; D000935:Antifungal Agents; D001393:Azoles; D002273:Carcinogens; D005656:Fungal Proteins; D000426:Alcohol Dehydrogenase; D000079:Acetaldehyde