title: [MC1R polymorphisms and facial photoaging].
abstract: BACKGROUND
  The objective of this study was to assess the association between melanocortin-1 receptor (MC1R) variants and the severity of facial skin photoaging.
  
  
  METHODS
  The study population comprised 530 French middle-aged women between 44 and 70 years. A trained dermatologist graded the severity of facial skin photoaging from photographs using Larnier's global scale. Logistic regressions were performed to assess the influence of MC1R polymorphism on severe photoaging (grades 1-3 vs. 4-6), with adjustment for possible confounders (demographic and phenotypic data, and sun exposure intensity).
  
  
  RESULTS
  Overall, 35% of the women were wild-type homozygotes, 49% had one variant, 15% had two variants, and 1% had at least one rare variant. After adjustment for possible confounders, the presence of two major diminished function variants was found to be a risk factor for photoaging (adjusted odds ratio=5.61; 95% confidence interval [1.43-21.96]).
  
  
  CONCLUSIONS
  Our results suggest that genetic variations of MC1R are important determinants for severe photoaging.
authors.affiliation: CE.R.I.E.S., unité de biométrie et épidémiologie, 20 rue Victor-Noir, Neuilly-sur-Seine, France.
authors.forename: J
authors.initials: J
authors.lastname: Latreille
authors.forename: K
authors.initials: K
authors.lastname: Ezzedine
authors.forename: A
authors.initials: A
authors.lastname: Elfakir
authors.forename: L
authors.initials: L
authors.lastname: Ambroisine
authors.forename: R
authors.initials: R
authors.lastname: Jdid
authors.forename: P
authors.initials: P
authors.lastname: Galan
authors.forename: S
authors.initials: S
authors.lastname: Hercberg
authors.forename: F
authors.initials: F
authors.lastname: Gruber
authors.forename: D
authors.initials: D
authors.lastname: Malvy
authors.forename: E
authors.initials: E
authors.lastname: Tschachler
authors.forename: C
authors.initials: C
authors.lastname: Guinot
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015986:Confounding Factors, Epidemiologic; D005260:Female; D005602:France; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006184:Habits; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D010858:Pigmentation; D011110:Polymorphism, Genetic; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics* / Q000502:physiology; D012307:Risk Factors; D015595:Skin Aging / Q000235:genetics* / Q000528:radiation effects; D013472:Sunlight
chemical_list: D044102:Receptor, Melanocortin, Type 1