title: Features of childhood atopic dermatitis.
abstract: Eczema or atopic dermatitis (AD) is the most common skin disease in children, and recent data derived from several studies showed that the prevalence of AD is still increasing in most Asian countries. The role of allergic reactions in AD is still a matter of debate. In some children allergy is not involved, while in others allergic reactions can trigger and maintain the skin lesions. Therefore, AD is now considered as a group of skin diseases with as a common feature the existence of a chronic skin inflammation. The underlying mechanisms of AD are not uniform, but differ from patient to patient, and also differ in one patient in time, suggesting the existence of different subtypes of AD, in a complex interplay. From different studies it is now suggested that at least 4 different players are involved in AD. These 4 players are: congenital skin barrier defects, allergy, autoimmunity (i.e. the production of autoantibodies against skin cells), and microbial agent colonization, especially colonization with bacteria, mainly Staphylococcus aureus. Much more needs to be discovered on the mechanisms of AD and other "players" might be discovered soon, as the current "4-player-model" cannot explain all features of AD. Treatment of AD might change in the near future. Today's cornerstones of treatment are still moisturizers (from a young age to prevent further skin barrier dysfunctions and allergic sensitization), local corticosteroids, and antiseptics, but new future therapeutic approaches become very likely.
authors.affiliation: Department of Pediatrics, Children's Medical Institute, National University Health System, Singapore. hugo_van_bever@nuhs.edu.sg
authors.forename: Hugo P S
authors.initials: HP
authors.lastname: Van Bever
authors.forename: Genevieve
authors.initials: G
authors.lastname: Llanora
mesh_terms: D015551:Autoimmunity; D002648:Child; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D012879:Skin Physiological Phenomena