title: Use of osteobiologics in the management of osteoporotic fractures.
abstract: Osteoporotic fractures present a number of significant challenges for surgical management, including high degrees of fracture comminution, poor implant fixation secondary to inferior bone quality, and compromised capacity for fracture healing. Osteobiologics are materials/agents that can promote fracture healing and enhance fracture stability. Given the challenges presented by osteoporotic fractures, they seem ideally suited to potentially benefit from the application of osteobiologics. Despite this, limited clinical investigation into the use of osteobiologics in the management of osteoporotic fractures has been performed. This article reviews a select number of osteobiologic products and the evidence for their use in osteoporotic fractures.
authors.affiliation: St. Michael's Hospital, 55 Queen St. East, Suite 800, Toronto, Ontario M5C1R6, Canada. aaron.nauth@utoronto.ca
authors.forename: Aaron
authors.initials: A
authors.lastname: Nauth
authors.forename: Theodore
authors.initials: T
authors.lastname: Miclau
authors.forename: Mohit
authors.initials: M
authors.lastname: Bhandari
authors.forename: Emil H
authors.initials: EH
authors.lastname: Schemitsch
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D001843:Bone Cements; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation; D002130:Calcium Phosphates / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use*; D005592:Fracture Fixation; D017102:Fracture Healing / Q000187:drug effects; D005598:Fractures, Spontaneous / Q000209:etiology / Q000628:therapy*; D006801:Humans; D019637:Orthopedic Procedures; D010012:Osteogenesis; D010024:Osteoporosis / Q000150:complications / Q000628:therapy*; D010281:Parathyroid Hormone / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D014184:Transplantation, Homologous
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D050071:Bone Density Conservation Agents; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D002130:Calcium Phosphates; D004164:Diphosphonates; D010281:Parathyroid Hormone; C020243:calcium phosphate