title: Functional properties of extracellular domains of transducer receptor gp130.
abstract: Cytokine receptor molecules have been shown to have extracellular domains of complex structure and a multi-step activation system. Glycoprotein gp130 is a typical transducer of cytokine signal; it functions by forming multicomponent receptor complexes and transferring signals of tens of cytokines from the IL-6 family. Structural organization and basic functioning principles of gp130 are well known, as well as related signal pathways, which function during normal differentiation and are involved in pathogenesis of many tumors. The role of gp130 in IL-6-dependent tumors is best studied. In this review, based on extensive accumulated data, we examine the functional significance of certain parts of gp130 extracellular domains. Potentials of a recently developed method for estimation of receptor activation at the level of epitope structure are discussed.
authors.affiliation: Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Kostjukova
authors.forename: N N
authors.initials: NN
authors.lastname: Tupitsyn
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D001665:Binding Sites; D050822:Cytokine Receptor gp130 / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D010449:Peptide Mapping; D055503:Protein Multimerization; D017434:Protein Structure, Tertiary; D000093242:Interleukin-6 Inhibitors
chemical_list: D000911:Antibodies, Monoclonal; D050822:Cytokine Receptor gp130; D015850:Interleukin-6; D000093242:Interleukin-6 Inhibitors