title: [Clinical features of parenteral nutrition associated cholestasis in preterm infants].
abstract: OBJECTIVE
  To analyze the clinical features and influential factors of parenteral nutrition associated cholestasis (PNAC) in preterm infants.
  
  
  METHODS
  A total of 159 infants with birth weight less than 2000 grams and/or gestational age less than 34 weeks were exposed to parenteral nutrition for longer than 14 days in NICU during the period from July 2007 to June 2009. Of these infants, 40 cases who had PNAC were aligned into the PNAC group, and the other 119 cases without PNAC were aligned into the non-PNAC group. PNAC occurring time, duration, the degree of PNAC and hepatic injury were observed. Logistic regression analysis was performed to evaluate the correlative factors of PNAC.
  
  
  RESULTS
  PNAC occurred about (3.3 ± 1.6) weeks after beginning PN, usually lasted for (13.3 ± 5.4) weeks. The maximum direct bilirubin was (135.2 ± 65.5) µmol/L. Of the PNAC patients, 73.7% suffered from hepatic injury. Hepatic injury usually occurred (6.6 ± 3.0) weeks after beginning PN, and lasted for (9.5 ± 5.4) weeks. The highest alanine aminotransferase (ALT) was (121.5 ± 48.4) U/L. The logistic regression of the possible correlative factors showed that time to start enteric feeding, persistence time of PN, asphyxia, small for gestational age, intracranial hemorrhage, were related to PNAC.
  
  
  CONCLUSIONS
  The prognosis of PNAC was good. Early enteral feeding, shorter time of PN, avoidance of the complications such as asphyxia and sepsis, were the important measures to lower PNAC.
authors.affiliation: Department of Neonatal Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 300003, China.
authors.forename: Chen-hong
authors.initials: CH
authors.lastname: Wang
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Shi
authors.forename: Xiu-jing
authors.initials: XJ
authors.lastname: Wu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Luo
mesh_terms: D002779:Cholestasis / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D010288:Parenteral Nutrition / Q000009:adverse effects*