title: Accumulation of mutant p53 protein correlates with elevation of serum afp in human hepatocellular-carcinoma.
abstract: A total of 88 specimens of hepatocellular carcinoma (HCC) and its surrounding liver tissues were studied to assess the role of a mutant p53 protein in HCC. The mutant p53 protein was evaluated by an immunoperoxidase detection system. Mutant p53 protein was detected in 46.6% of HCC specimens, and in 70.6% of surrounding liver tissues. A statistically significant association was found between the elevation of serum AFP and the accumulation of mutant p53 in HCCs (P<0.05), and in surrounding liver tissues (P<0.005). These results imply that mutant p53 protein may function as a regulatory factor in the transcription of the AFP gene during development of HCC.
authors.affiliation: SHANGHAI MED UNIV,INST LIVER CANC,136 YI XUE YUAN RD,SHANGHAI 200032,PEOPLES R CHINA.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Tang
authors.forename: K
authors.initials: K
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Ye
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: W
authors.initials: W
authors.lastname: Bao