title: Functional state of rat cardiomyocytes and blood antioxidant system under psycho-emotional stress.
abstract: We studied the functionality of the antioxidant system in laboratory rat cardiomyocytes and blood under psycho-emotional stress. It was found that 40-day isolation and violation of diurnal cycle among the animals were accompanied by the intensification of lipid peroxidation process and marked with a reduced activity of antioxidant system enzymes, such as catalase and superoxide dismutase activity. The results suggested that psycho-emotional stress was accompanied by oxidative stress, causing a reduction in the intensity of energy metabolism in cardiomyocytes, which was further strengthened by the fact that the activity of the enzymes involved in ATP synthesis in mitochondria was reduced. Based on the results, we proposed that psychological stress is one of the factors contributing to the development of various cardiac diseases.
authors.affiliation: Department of Biology, Faculty of Exact and Natural Sciences, Iv. Javakhishvili Tbilisi State University, Georgia. zurabiku@gmail.com
authors.forename: Zurab
authors.initials: Z
authors.lastname: Kuchukashvili
authors.forename: Ketevan
authors.initials: K
authors.lastname: Menabde
authors.forename: Matrona
authors.initials: M
authors.lastname: Chachua
authors.forename: George
authors.initials: G
authors.lastname: Burjanadze
authors.forename: Manana
authors.initials: M
authors.lastname: Chipashvili
authors.forename: Nana
authors.initials: N
authors.lastname: Koshoridze
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002940:Circadian Rhythm; D004734:Energy Metabolism / Q000502:physiology; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D032383:Myocytes, Cardiac / Q000378:metabolism*; D009569:Nitric Oxide / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012934:Social Isolation; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*
chemical_list: D000975:Antioxidants; D008055:Lipids; D009569:Nitric Oxide