title: The role of natural-killer-cells in the pathogenesis of epstein-barr virus-associated burkitt-lymphoma in a scid mouse model.
abstract: Epstein-Barr virus (EBV) is associated with both benign and malignant lymphoproliferative processes. Recently, mice with severe combined immunodeficiency (SCID) have been described that develop EBV-induced lymphomas when inoculated with peripheral blood lymphocytes from EBV-seropositive individuals. To investigate the pathogenesis of EBV-associated Burkitt lymphomas, we intraperitoneally inoculated SCID mice with cells from EBV-infected Burkitt lymphoma (BL) cell lines. In general, cells from BL lines developed into BL-like tumors. Certain BL cell lines, however, were not particularly tumorigenic in these animals. Antibody capable of depleting mice of natural killer cells (anti-asialo GM1) favored the development of these Burkitt lymphomas. The pathogenetic implications of this animal model for human disease is discussed.
authors.affiliation: YALE UNIV,SCH MED,DEPT PEDIAT,NEW HAVEN,CT 06510. YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH,NEW HAVEN,CT 06510. YALE UNIV,SCH MED,DEPT PATHOL,NEW HAVEN,CT 06510.
authors.forename: B
authors.initials: B
authors.lastname: Katz
authors.forename: B
authors.initials: B
authors.lastname: Salimi
authors.forename: U
authors.initials: U
authors.lastname: Saini
authors.forename: J
authors.initials: J
authors.lastname: McNamara
authors.forename: R
authors.initials: R
authors.lastname: Eisen