title: Iron homeostasis and management of oxidative stress response in bacteria.
abstract: Iron is both an essential nutrient for the growth of microorganisms, as well as a dangerous metal due to its capacity to generate reactive oxygen species (ROS) via the Fenton reaction. For these reasons, bacteria must tightly control the uptake and storage of iron in a manner that restricts the build-up of ROS. Therefore, it is not surprising to find that the control of iron homeostasis and responses to oxidative stress are coordinated. The mechanisms concerned with these processes, and the interactions involved, are the subject of this review.
authors.affiliation: Microbial Interactions, Department of Molecular and Cellular Interactions, VIB and Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. pcornel@vub.ac.be
authors.forename: Pierre
authors.initials: P
authors.lastname: Cornelis
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.forename: Simon C
authors.initials: SC
authors.lastname: Andrews
authors.forename: Tiffany
authors.initials: T
authors.lastname: Vinckx
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D006706:Homeostasis; D007501:Iron / Q000378:metabolism*; D008954:Models, Biological; D018384:Oxidative Stress; D010544:Peroxidases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D017382:Reactive Oxygen Species; D012097:Repressor Proteins; C068477:ferric uptake regulating proteins, bacterial; D007501:Iron; D010544:Peroxidases; D002374:Catalase