title: Peritoneal immune system in patients with advance epithelial ovarian cancer.
abstract: The development of epithelial ovarian cancer is associated with changes in the peritoneal cavity microenvironment. Tumor cells produce different factors, which impairs differentiation, maturation, and function of antigen-presenting cells. In this review, we focus on selected cell populations in the peritoneal cavity immune system and their potential role in epithelial ovarian cancer immunopathogenesis. We devote most attention to dendritic cells because they are considered to be superior in their antigen-presenting ability, compared with both macrophages and B lymphocytes. We also present a brief characterization of tumor-infiltraiting cells in epithelial ovarian cancer patients.
authors.affiliation: I Chair and Department of Oncological Gynaecology and Gynaecology, Medical University, Lublin, Poland. iwonawertel@wp.pl
authors.forename: Iwona
authors.initials: I
authors.lastname: Wertel
authors.forename: Aldona
authors.initials: A
authors.lastname: Nowicka
authors.forename: Ewelina
authors.initials: E
authors.lastname: Rogala
authors.forename: Jan
authors.initials: J
authors.lastname: Kotarski
mesh_terms: D001202:Ascitic Fluid / Q000166:cytology* / Q000276:immunology*; D000077216:Carcinoma, Ovarian Epithelial; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D005260:Female; D006801:Humans; D007107:Immune System / Q000276:immunology; D016246:Lymphocytes, Tumor-Infiltrating / Q000166:cytology / Q000276:immunology*; D009375:Neoplasms, Glandular and Epithelial / Q000276:immunology / Q000473:pathology; D010051:Ovarian Neoplasms / Q000276:immunology / Q000473:pathology