title: The Roche Cancer Genome Database 2.0.
abstract: BACKGROUND
  Cancer is a disease of genome alterations that arise through the acquisition of multiple somatic DNA sequence mutations. Some of these mutations can be critical for the development of a tumor and can be useful to characterize tumor types or predict outcome.
  
  
  METHODS
  We have constructed an integrated biological information system termed the Roche Cancer Genome Database (RCGDB) combining different human mutation databases already publicly available. This data is further extended by hand-curated information from publications.The current version of the RCGDB provides a user-friendly graphical interface that gives access to the data in different ways: (1) Single interactive search by genes, samples, cell lines, diseases, as well as pathways, (2) batch searches for genes and cell lines, (3) customized searches for regularly occurring requests, and (4) an advanced query interface enabling the user to query for samples and mutations by various filter criteria.
  
  
  CONCLUSIONS
  The interfaces of the presented database enable the user to search and view mutations in an intuitive and straight-forward manner. The database is freely accessible at http://rcgdb.bioinf.uni-sb.de/MutomeWeb/.
authors.affiliation: Roche Diagnostics GmbH Pharma Research and Early Development Informatics, Penzberg, Germany. jan.kuentzer@roche.com
authors.forename: Jan
authors.initials: J
authors.lastname: Küntzer
authors.forename: Daniela
authors.initials: D
authors.lastname: Maisel
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Lenhof
authors.forename: Stefan
authors.initials: S
authors.lastname: Klostermann
authors.forename: Helmut
authors.initials: H
authors.lastname: Burtscher
mesh_terms: D030541:Databases, Genetic; D066246:ErbB Receptors / Q000235:genetics; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D057386:Search Engine
chemical_list: D066246:ErbB Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human