title: The effects of leukemia inhibitory factor (lif) on cell multiplication and locomotion in human teratocarcinoma cells.
abstract: The human teratocarcinoma cell line (Tera 2) could be stimulated to a moderate increase in cell number in serum-free medium by addition of 5 ng leukemia inhibitory factor (LIF)/ml. However this effect was only observed in short term (24 h) cultures. By comparing cell numbers with thymidine incorporation data and proportion intact cell nuclei, we concluded that this short term increase in cell number was due to enhanced cell survival rather than a real increase in the proportion of cells traversing the cell cycle. When increased concentrations of LIF were added a preferential effect on clonal cell locomotion was observed. 50-200 ng of LIF stimulated cell movement but exerted no effect on Tera 2 cell proliferation at any time interval studied.
authors.affiliation: SWEDISH UNIV AGR SCI,DEPT PATHOL,S-75007 UPPSALA,SWEDEN. CANC RES CAMPAIGN,DEV TUMOUR RES LAB,OXFORD,ENGLAND.
authors.forename: M
authors.initials: M
authors.lastname: Granerus
authors.forename: P
authors.initials: P
authors.lastname: Bierke
authors.forename: W
authors.initials: W
authors.lastname: Engstrom