title: Antifouling poly(β-peptoid)s.
abstract: A new type of polymer highly resistant to nonspecific protein adsorption is reported. Poly(N-methyl-β-alanine) (PMeA) and poly(N-ethyl-β-alanine) (PEtA) synthesized via cobalt-catalyzed carbonylative polymerization of N-methylaziridine and N-ethylaziridine were end-functionalized with thiol groups and grafted onto Au surfaces. Protein adsorption was studied by the surface plasmon resonance (SPR) method. The amounts of representative single proteins adsorbed onto the PMeA- and PEtA-grafted surfaces were below the detection limit of SPR at the pg/mm(2) level. After exposure to full blood plasma and serum for 10 min, protein adsorption was at the level of ∼ 100 pg/mm(2), similar to the level of protein adsorption on poly(ethylene glycol) surfaces subjected to identical conditions. These poly(β-peptoid)s therefore provide excellent protein resistance comparable to the best antifouling materials known to date. The strong proton-accepting ability when forming hydrogen bonds is suggested to be an important attribute for these poly(β-peptoid)s as well as other poly(tertiary amide)s as antifouling materials.
authors.affiliation: Department of Polymer Science, The University of Akron, 170 University Avenue, Akron, Ohio 44325, USA.
authors.forename: Shaohui
authors.initials: S
authors.lastname: Lin
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Skoumal
authors.forename: Brian
authors.initials: B
authors.lastname: Ramunno
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Li
authors.forename: Chrys
authors.initials: C
authors.lastname: Wesdemiotis
authors.forename: Lingyun
authors.initials: L
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Jia
mesh_terms: D000327:Adsorption; D000818:Animals; D057219:Biofouling / Q000517:prevention & control*; D002417:Cattle; D002645:Chickens; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013237:Stereoisomerism; D020349:Surface Plasmon Resonance; D013499:Surface Properties
chemical_list: D011108:Polymers; D012710:Serum Albumin, Bovine; D005340:Fibrinogen; C421864:hen egg lysozyme; D009113:Muramidase