title: Outcome of non-metastatic male breast cancer: 118 patients.
abstract: Studies concerning adjuvant systemic therapy and prognosis in male breast carcinoma (MBC) are limited. We aimed to evaluate outcome of the changing practices of adjuvant systemic treatment and survival in operable MBC patients over the last two decades. The medical records of 148 MBC patients followed between the years 1986 and 2009 at 7 cancer center were evaluated retrospectively. One hundred and eighteen operable non-metastatic patients had sufficient data were included the study. One hundred and eighteen operable MBC were found to be eligible. Median age was 60 (range 29-83) years. Thirty-two percent of the patients had T3-4 tumors. Half of the patients had axillary lymph node-positive disease. The proportion of positivity of estrogen receptor(ER), progesterone receptor (PgR), and HER2 status were 82.9, 75.8, and 23.4%, respectively. Only, 7 patients had triple negative (TN). Adjuvant hormonotherapy was advised for 76.8% whereas adjuvant chemotherapy for 73.7% of the patients. Median follow-up was 40.9 months (range 3.8-186 months). Locoregional and/or distant recurrence developed in thirty-eight patients (32.2%). Twenty-three patients died during the follow-up period. Five-year disease-free survival (DFS) was found to be 60%, whereas overall survival (OS) was 82%. Larger tumor size and lymph node positivity were statistically significant poor prognostic factors for OS. Although statistical insignificant, patients with HER2-positive tumors have worse DFS (52 vs. 120 months, log rank P = .73) and OS (85 vs. 144 months, log rank P = .30) than HER2-negative ones. Although the frequency of the use of adjuvant systemic therapy in MBC has been increasing and survival rates improving for the last decades, lymph node status and tumor size are still the most important determining factors for prognosis. There is a need for further prognostic information in men with HER2-positive or TN breast cancer.
authors.affiliation: Department of 2nd Medical Oncology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Ulkü Yalçıntaş
authors.initials: UY
authors.lastname: Arslan
authors.forename: Berna
authors.initials: B
authors.lastname: Oksüzoğlu
authors.forename: Nuriye
authors.initials: N
authors.lastname: Ozdemir
authors.forename: Sercan
authors.initials: S
authors.lastname: Aksoy
authors.forename: Necati
authors.initials: N
authors.lastname: Alkış
authors.forename: Ayşe
authors.initials: A
authors.lastname: Gök
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Kaplan
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gümüş
authors.forename: Veli
authors.initials: V
authors.lastname: Berk
authors.forename: Doğan
authors.initials: D
authors.lastname: Uncu
authors.forename: Meltem
authors.initials: M
authors.lastname: Baykara
authors.forename: Dilşen
authors.initials: D
authors.lastname: Colak
authors.forename: Ummügül
authors.initials: U
authors.lastname: Uyetürk
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Türker
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Işıkdoğan
mesh_terms: D002288:Adenocarcinoma, Mucinous; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018567:Breast Neoplasms, Male / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D018275:Carcinoma, Lobular / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone