title: Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.
abstract: OBJECTIVE
  To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest.
  
  
  METHODS
  Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls.
  
  
  RESULTS
  The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001).
  
  
  CONCLUSIONS
  The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.
authors.affiliation: Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan. toshim@asahikawa-med.ac.jp
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Tsujimura
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyagawa
authors.forename: Eitetsu
authors.initials: E
authors.lastname: Koh
authors.forename: Mikio
authors.initials: M
authors.lastname: Namiki
authors.forename: Michiharu
authors.initials: M
authors.lastname: Horikawa
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Saijo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sengoku
mesh_terms: D044466:Asian People; D053713:Azoospermia / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008540:Meiosis; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: C499858:UBR2 protein, human; D044767:Ubiquitin-Protein Ligases