title: Genetic loci for blood lipid levels identified by linkage and association analyses in Caribbean Hispanics.
abstract: To identify genetic loci influencing blood lipid levels in Caribbean Hispanics, we first conducted a genome-wide linkage scan in 1,211 subjects from 100 Dominican families on five lipid quantitative traits: total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), and LDL-C/HDL-C ratio. We then investigated the association between blood lipid levels and 21,361 single nucleotide polymorphisms (SNP) under the 1-logarithm of odds (LOD) unit down regions of linkage peaks in an independent community-based subcohort (N = 814, 42% Dominican) from the Northern Manhattan Study (NOMAS). We found significant linkage evidence for LDL-C/HDL-C on 7p12 (multipoint LOD = 3.91) and for TC on 16q23 (LOD = 3.35). In addition, we identified suggestive linkage evidence of LOD > 2.0 on 15q23 for TG, 16q23 for LDL-C, 19q12 for TC and LDL-C, and 20p12 for LDL-C. In the association analysis of the linkage peaks, we found that seven SNPs near FLJ45974 were associated with LDL-C/HDL-C with a nominal P < 3.5 × 10(-5), in addition to associations (P < 0.0001) for other lipid traits with SNPs in or near CDH13, SUMF2, TLE3, FAH, ARNT2, TSHZ3, ZNF343, RPL7AL2, and TMC3. Further studies are warranted to perform in-depth investigations of functional genetic variants in these regions.
authors.affiliation: Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Chuanhui
authors.initials: C
authors.lastname: Dong
authors.forename: Ashley
authors.initials: A
authors.lastname: Beecham
authors.forename: Liyong
authors.initials: L
authors.lastname: Wang
authors.forename: Susan
authors.initials: S
authors.lastname: Slifer
authors.forename: Clinton B
authors.initials: CB
authors.lastname: Wright
authors.forename: Susan H
authors.initials: SH
authors.lastname: Blanton
authors.forename: Tatjana
authors.initials: T
authors.lastname: Rundek
authors.forename: Ralph L
authors.initials: RL
authors.lastname: Sacco
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D017691:Caribbean Region / Q000208:ethnology; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D056426:Genetic Loci / Q000235:genetics*; D023281:Genomics; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D008055:Lipids