title: [Combination chemotherapy of docetaxel and UFT against hormone refractory prostate cancer].
abstract: Docetaxel-based chemotherapy has been shown to be effective and well tolerated by Japanese patients with metastatic hormone-refractory prostate cancer (HRPC). This study was undertaken to assess the feasibility of docetaxel in combination with UFT (a combination of tegafur and uracil) in Japanese patients with HRPC. Ten patients aged 60-86 years with HRPC, who were pre-treated with hormonal therapy and expected to have more than 3 month survival and without major organ dysfunction, were included in this study. Treatment consisted of docetaxel 70 mg/m2 every 3 weeks plus UFT 260 mg/m2 /day. The primary end point was prostate-specific antigen (PSA) response, and the secondary end points included progression-free survival and toxicity. Nine patients were evaluable for efficacy and toxicity. The PSA response rate was 50% (1 CR and 4 PR). The most common non-hematological adverse events (of any grade) possibly related to treatment were neutropenia and anorexia. Grade 3/4 neutropenia and anorexia occurred in 50 and 20% of patients, respectively. The combination of docetaxel and UFT was feasible and active in Japanese patients with HRPC, with a manageable adverse-event profile similar to that observed in lung cancer chemotherapy.
authors.affiliation: The Department of Medical Oncology, Kanazawa Medical University.
authors.forename: Takeo
authors.initials: T
authors.lastname: Shimasaki
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Miyazawa
authors.forename: Manabu
authors.initials: M
authors.lastname: Moriyama
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Itaru
authors.initials: I
authors.lastname: Sato
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakaya
authors.forename: Hideo
authors.initials: H
authors.lastname: Nakajima
authors.forename: Anna
authors.initials: A
authors.lastname: Kubo
authors.forename: Koji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Motoo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D000077143:Docetaxel; D019008:Drug Resistance, Neoplasm; D005240:Feasibility Studies; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D043823:Taxoids / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D006728:Hormones; D043823:Taxoids; D005641:Tegafur; D000077143:Docetaxel; D014498:Uracil