title: Higher adherence to French dietary guidelines and chronic diseases in the prospective SU.VI.MAX cohort.
abstract: OBJECTIVE
  Nutritional recommendations are widely disseminated, but assessment of their predictive value for risk of chronic diseases and mortality is essential for ensuring their validity. We evaluated, in a large population-based study, the association between the French Programme National Nutrition Santé (PNNS) Guideline Score (GS) (maximum score of 15 points), an a priori-based score, and the incidences of cancer, cardiovascular disease (CVD) and overall mortality.
  
  
  METHODS
  Subjects included in this analysis (n=5823) were participants in the Supplémentation en Vitamines et Minéraux AntioXydants study, with available data for estimating the PNNS-GS. Hazards ratios (HRs) and 95% confidence intervals (95% CIs) for outcomes (cancer, CVD and death) were estimated across quartiles of PNNS-GS using Cox proportional hazards models.
  
  
  RESULTS
  A total of 734 major events were recorded during an average 11.6-year follow-up (maximum 13 years): 423 cancers, 193 ischemic diseases and 118 deaths. In the fully adjusted model, a significant reduction in CVD risk between the first and fourth PNNS-GS quartiles (HR=0.65, 95% CI=0.41, 1.00, P for trend=0.04) was observed. No significant overall association with risk of cancer or death was detected.
  
  
  CONCLUSIONS
  These observations support the role of nutritional guidelines in prevention of CVD.
authors.affiliation: UREN, U557 INSERM/U1125 INRA/CNAM/Paris 13 Université, CRNH IdF, Bobigny, France. e.kesse@uren.smbh.univ-paris13.fr
authors.forename: E
authors.initials: E
authors.lastname: Kesse-Guyot
authors.forename: M
authors.initials: M
authors.lastname: Touvier
authors.forename: A
authors.initials: A
authors.lastname: Henegar
authors.forename: S
authors.initials: S
authors.lastname: Czernichow
authors.forename: P
authors.initials: P
authors.lastname: Galan
authors.forename: S
authors.initials: S
authors.lastname: Hercberg
authors.forename: K
authors.initials: K
authors.lastname: Castetbon
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D002908:Chronic Disease; D004032:Diet / Q000592:standards*; D004311:Double-Blind Method; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D017408:Guidelines as Topic; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D011795:Surveys and Questionnaires