title: B-cell lymphoma infiltration of cerebrospinal fluid with minimal symptoms and benign course.
abstract: We report a patient diagnosed with a B-cell lymphoma after detecting monoclonal B-cells in the cerebrospinal fluid (CSF) and who had only minimal symptoms and a benign course. A 46-year-old man experienced three transitory episodes with neurological symptoms. On examination papilledema in both eyes was found. Flow cytometry (FACS)-analysis detected monoclonal B-cells in the CSF as well as in the peripheral blood and the bone marrow. Results were consistent with a low-risk lymphoma, most probably a marginal zone B-cell lymphoma. Interestingly, our patient had no progressive clinical symptoms and remained without specific therapy during 36 months of follow-up. Nevertheless, CSF-analysis led to the diagnosis of the B-cell lymphoma.
authors.affiliation: Department of Neurology, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover 30625, Germany. skripuletz.thomas@mh-hannover.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Skripuletz
authors.forename: Refik
authors.initials: R
authors.lastname: Pul
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wurster
authors.forename: Dietrich
authors.initials: D
authors.lastname: Peest
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dengler
authors.forename: Martin
authors.initials: M
authors.lastname: Stangel
mesh_terms: D000849:Anomia / Q000209:etiology; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002469:Cell Separation; D003882:Dermatomyositis / Q000473:pathology; D005434:Flow Cytometry; D006261:Headache / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D006987:Hypesthesia / Q000209:etiology; D016130:Immunophenotyping; D007964:Leukocytosis / Q000134:cerebrospinal fluid*; D016393:Lymphoma, B-Cell / Q000134:cerebrospinal fluid* / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D010211:Papilledema / Q000209:etiology; D013064:Speech Disorders / Q000209:etiology; D013163:Splenomegaly / Q000473:pathology; D014786:Vision Disorders / Q000209:etiology
chemical_list: D000959:Antihypertensive Agents