title: Life imprints: living in a contaminated world.
abstract: BACKGROUND
  The links between nature and nurture need to be redefined to accommodate anthropogenic chemical contamination. Although some local remediation of contamination has occurred, at the global level this is simply not possible. Contaminants are spread by population migration, by introduction via the food chain, and through air and water currents, even to regions that were never exposed directly to these environmental insults. In recognizing and accepting this worldwide change, we must move on and consider the types of adaptations that could occur as a consequence.
  
  
  OBJECTIVE
  We propose a paradigm shift in the field that integrates various disciplines involved in the study of environmental contamination to recognize that contamination is widespread and cannot be remedied at the global level.
  
  
  CONCLUSIONS
  Greater effort must be placed on integrative and interdisciplinary studies that explicitly illuminate how the causal mechanisms and functional outcomes of related processes operate at each level of biological organization while at the same time revealing the relations among the levels.
  
  
  CONCLUSIONS
  To anticipate and understand the future, we must devote more study to what is likely to happen and less to what has happened. Only then will we begin to understand how ancestral environmental exposures act at both the level of the individual and the level of their descendants to influence all aspects of life history.
authors.forename: David
authors.initials: D
authors.lastname: Crews
authors.forename: Andrea C
authors.initials: AC
authors.lastname: Gore
mesh_terms: D000818:Animals; D052244:Endocrine Disruptors / Q000378:metabolism / Q000633:toxicity; D004703:Endocrine System / Q000187:drug effects*; D004781:Environmental Exposure; D044127:Epigenesis, Genetic; D005260:Female; D008297:Male; D012098:Reproduction
chemical_list: D052244:Endocrine Disruptors