title: In vivo assessment of chitosan/β-glycerophosphate as a new liquid embolic agent.
abstract: We sought to assess the feasibility of using thermosensitive chitosan/β-glycerophosphate forembolotherapy. The renal arteries in nine rabbits were embolized with chitosan/β-glycero-phosphate. The animals were studied angiographically and sacrificed at one week (n = 3), four weeks (n = 3), and eight weeks (n = 3) after embolotherapy. Histology was obtained at these three time points. Delivery of chitosan/β-glycerophosphate was successful in all cases. Complete occlusion was achieved in all cases. No recanalization was observed in the follow-up angiograms. No untoward inflammatory reactions were observed in the target renal arteries and infarcted kidneys during the histological examinations. Our preliminary feasibility evaluation in rabbit renal arteries indicates that C/GP is a satisfactory embolization agent.
authors.affiliation: First Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: N
authors.initials: N
authors.lastname: Xu
authors.forename: Q
authors.initials: Q
authors.lastname: Luo
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Xu
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Zhen
mesh_terms: D015901:Angiography, Digital Subtraction; D000818:Animals; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D004621:Embolization, Therapeutic / Q000379:methods*; D005994:Glycerophosphates / Q000737:chemistry / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D007269:Injections, Intra-Arterial; D023421:Models, Animal; D011817:Rabbits; D012077:Renal Artery / Q000000981:diagnostic imaging* / Q000473:pathology; D013696:Temperature
chemical_list: D005994:Glycerophosphates; D048271:Chitosan; C031463:beta-glycerophosphoric acid