title: Comparison of bare metal stent and paclitaxel-eluting stent using a novel rat aorta stent model.
abstract: The purpose of our study was to create a novel rat aorta stent implantation model. Stainless steel bare metal stents (BMS) or paclitaxel-eluting stents (PES) were implanted in male Sprague-Dawley rats (BW 400 ± 20 g). Two and four weeks after stent implantation, the aorta were collected, fixed with 2% glutaraldehyde, and cut into two segments. One segment was used for scanning electron microscopy analysis to evaluate re-endothelialization, and the other segment was used to calculate the neointimal area. At 2 weeks after stenting, the appearance of neointimal hyperplasia was less in the PES group than in the BMS group. At 4 weeks after stenting, no significant difference in neointimal hyperplasia was observed between two groups. On the other hand, the PES group showed more thrombus formation and less re-endothelialization compared to the BMS group. This study demonstrated the ability of a novel rat model of aorta stenting via a common carotid artery to measure the efficacy and safety of commercially available drug-eluting stents.
authors.affiliation: Department of Cardiology, Chonnam National University Hospital, Gwanju 501-757, Korea.
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Kwon
authors.forename: Rho Kwan
authors.initials: RK
authors.lastname: Park
authors.forename: Tae Jin
authors.initials: TJ
authors.lastname: Shim
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Jeong
authors.forename: Myeong Chan
authors.initials: MC
authors.lastname: Cho
authors.forename: Youngkeun
authors.initials: Y
authors.lastname: Ahn
authors.forename: Dong-Woon
authors.initials: DW
authors.lastname: Kim
mesh_terms: D017130:Angioplasty / Q000379:methods*; D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery* / Q000648:ultrastructure; D003324:Coronary Artery Disease / Q000601:surgery*; D054855:Drug-Eluting Stents; D006651:Histocytochemistry; D008297:Male; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D058426:Neointima / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D017239:Paclitaxel