title: Frostbite-like skin lesion as an autonomic symptom of Isaacs' syndrome.
abstract: A 25-year-old woman complained of numbness of the extremities, following muscle rigidity and tenderness. The presence of anti-voltage-gated potassium channel antibody led to the diagnosis of Isaacs' syndrome. Twenty-seven months after the first symptom, she developed a pricking pain sensation in the lateral left foot, and then gradually developed a purple skin lesion resembling frostbite. The lesion completely disappeared 2 days later. An incidental episode occurred at the same site 8 months later. Frostbite-like skin lesions may be a rare autonomic manifestation in Isaacs' syndrome.
authors.affiliation: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Doi
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Arimura
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Ohyagi
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kira
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001341:Autonomic Nervous System / Q000276:immunology / Q000503:physiopathology; D005260:Female; D005627:Frostbite / Q000175:diagnosis*; D006801:Humans; D020386:Isaacs Syndrome / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D024642:Potassium Channels, Voltage-Gated / Q000037:antagonists & inhibitors / Q000276:immunology
chemical_list: D001323:Autoantibodies; D024642:Potassium Channels, Voltage-Gated