title: Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae.
abstract: Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan.
authors.affiliation: College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, South Korea.
authors.forename: Joon-Seok
authors.initials: JS
authors.lastname: Choi
authors.forename: Kyung-Mi
authors.initials: KM
authors.lastname: Choi
authors.forename: Cheol-Koo
authors.initials: CK
authors.lastname: Lee
mesh_terms: D031204:Caloric Restriction; D045222:Electron Transport Chain Complex Proteins / Q000235:genetics / Q000378:metabolism*; D008136:Longevity; D053078:Membrane Potential, Mitochondrial; D008928:Mitochondria / Q000201:enzymology / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D045222:Electron Transport Chain Complex Proteins