title: Expression of tyrosine kinases encoding protooncogenes in differentiating human leukemia-cells.
abstract: We investigated the expression of the tyrosine kinase encoding proto-oncogenes c-src and fyn during in vitro differentiation of the human promyelocytic leukemia cell line HL-60 and an HL-60 derived cell line (HL-GOT) with an altered T-cell receptor gene. In HL-60 cells, the fyn and c-src encoded tyrosine kinases are activated in a differentiation-dependent manner, whereas in HL-60T cells high levels of pp59(fyn) and pp60(c-src) specific kinase activities are already present in the untreated cells. From the data obtained we conclude that untreated HL-60T cells represent a more differentiated type of cells compared to the untreated promyelocytic HL-60 cells.
authors.affiliation: UNIV MUNSTER,DEPT EXPTL TUMORBIOL,D-48149 MUNSTER,GERMANY.
authors.forename: M
authors.initials: M
authors.lastname: Gismann
authors.forename: B
authors.initials: B
authors.lastname: Quack
authors.forename: A
authors.initials: A
authors.lastname: Barnekow