title: Esophageal small-cell carcinoma with syndrome of inappropriate secretion of antidiuretic hormone.
abstract: Small-cell carcinoma (SCC) of the esophagus is rare, and its clinical characteristics remain poorly understood. A 54-year-old man was given a diagnosis of esophageal SCC and underwent esophagectomy. Four months after surgery, he was admitted to our hospital because of rapidly developing hyponatremia. Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) due to extensive recurrence of SCC was diagnosed. Combined chemotherapy with irinotecan and cisplatin has dramatically reduced metastatic tumors, and it was concomitantly effective for SIADH. This case demonstrates that esophageal SCC could induce SIADH as a paraneoplastic syndrome and that the above combined chemotherapy was feasible and effective.
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ando
authors.forename: Ayumu
authors.initials: A
authors.lastname: Hosokawa
authors.forename: Hidemoto
authors.initials: H
authors.lastname: Yamawaki
authors.forename: Yuushi
authors.initials: Y
authors.lastname: Hasumoto
authors.forename: Shinya
authors.initials: S
authors.lastname: Kajiura
authors.forename: Yuko
authors.initials: Y
authors.lastname: Itaya
authors.forename: Akira
authors.initials: A
authors.lastname: Ueda
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzuki
authors.forename: Jun
authors.initials: J
authors.lastname: Nishikawa
authors.forename: Haruka
authors.initials: H
authors.lastname: Fujinami
authors.forename: Takako
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Kouhei
authors.initials: K
authors.lastname: Ogawa
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D017809:Fatal Outcome; D006801:Humans; D007010:Hyponatremia / Q000209:etiology; D007177:Inappropriate ADH Syndrome / Q000188:drug therapy / Q000209:etiology*; D000077146:Irinotecan; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000188:drug therapy; D018358:Neuroendocrine Tumors / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D009384:Paraneoplastic Endocrine Syndromes / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin