title: In-vitro antitumor-activity of the plant ribosome-inactivating proteins map-30 and gap-31.
abstract: MAP 30 and GAP 31 are plant proteins isolated from Momordica charantia and Gelonium multiflorum, respectively. They have recently been shown to inhibit HIV-1 infection and replication. These proteins also possess a novel DNA topoisomerase-poison-like activity as well as ribosome inactivation. They were submitted to the Anti-Cancer Drug Screening Program of the National Cancer Institute and found to have potent anti-tumor activity against certain human tumor cell lines. The most sensitive cell lines responded to MAP 30 and GAP 31 with GI(50) that ranged from 0.01 to 10 mu g/ml and were unrelated to tumor type. These included cell lines from renal, non-small cell lung, and breast cancer. Targeted immunofusions made with MAP 30 or GAP 31 may be most effective toward these types of tumors.
authors.affiliation: PROGRAM RESOURCES INC,DYNCORP,BIOL CARCINOGENESIS & DEV PROGRAM,FREDERICK,MD 21702. NICHHD,ENDOCRINOL & REPROD RES BRANCH,BETHESDA,MD 20892. NYU,SCH MED,DEPT BIOCHEM,NEW YORK,NY 10016. AMER BIOSCI,NEW YORK,NY 10021.
authors.forename: S
authors.initials: S
authors.lastname: Rybak
authors.forename: J
authors.initials: J
authors.lastname: Lin
authors.forename: D
authors.initials: D
authors.lastname: Newton
authors.forename: H
authors.initials: H
authors.lastname: Kung
authors.forename: A
authors.initials: A
authors.lastname: Monks
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: P
authors.initials: P
authors.lastname: Huang
authors.forename: S
authors.initials: S
authors.lastname: Leehuang