title: Analysis of factors affecting the long-term functional outcome of patients with skull base meningioma.
abstract: We analyzed the factors that affect the long-term clinical outcome of a series of patients with skull base meningiomas. Clinical records of 73 patients with cranial base meningiomas were reviewed retrospectively, of whom 13 patients experienced a recurrence at various times following the initial surgery. The mean follow-up time was 90.4 ± 21.2 months (range=60-124 months). Based on the location of the recurrence, patients with recurrence were divided into peripheral (n=6) and central (n=7) skull base groups. Of several variables analyzed using a multivariate logistic regression model, "high MIB-1 (Ki-67 proliferation antigen) labeling index" was an independent variable predicting poor long-term functional outcomes. Recurrence of the tumor at the central skull base was also a strong predictor of poor long-term outcomes. An increased proliferative potential, as indicated by a high MIB-1 labeling index, may induce repeated recurrences, eventually leading to worse functional outcomes, particularly for patients with central skull base meningiomas.
authors.affiliation: Department of Neurological Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, Japan. nnakao@wakayama-med.ac.jp
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Nakao
authors.forename: Toshika
authors.initials: T
authors.lastname: Ohkawa
authors.forename: Junichirou
authors.initials: J
authors.lastname: Miki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nishibayahsi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Ogura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Uematsu
authors.forename: Toru
authors.initials: T
authors.lastname: Itakura
mesh_terms: D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D019394:Ki-67 Antigen / Q000032:analysis / Q000378:metabolism; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D020127:Recovery of Function; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D019394:Ki-67 Antigen