title: Analgesic and anti-nociceptive activity of hydroethanolic extract of Drymaria cordata Willd.
abstract: OBJECTIVE
  To study the analgesic and anti-nociceptive activity of hydroethanolic extract of Drymaria cordata Willd.
  
  
  METHODS
  Wistar rats and Swiss albino mice were used for studying analgesic and anti-nociceptive activity of Drymaria cordata hydroethanolic extract (DCHE) at doses 50, 100 and 200 mg/kg p.o. Various models viz. acetic acid induced writhing model (female mice), Eddy's hot plate (mice) and tail flick model (rat) for analgesic study and formalin-induced paw licking model (mice) were used for anti-nociceptive study.
  
  
  RESULTS
  In acetic acid induced writhing model, effect of DCHE was better than the standard drug- indomethacin 10 mg/kg (p.o.). In the hot plate model, the maximum effect was observed at 60 min at a dose of 200 mg/kg p.o., which was higher than the standard drug morphine sulfate (1.5 mg/kg i.p.), whereas in the tail flick model, effect was comparable with morphine sulfate. In formalin-induced paw licking model, administration of DCHE completely abolished the early phase at 100 and 200 mg/kg p.o. and in the late phase, the effect of DCHE (200 mg/kg p.o.) was higher than indomethacin (10 mg/kg p.o.).
  
  
  CONCLUSIONS
  DCHE was effective in both non-narcotic and narcotic models of nociception, suggesting its possible action via peripheral and central mechanism. It also abolished the early phase in formalin-induced paw licking model, suggesting complete inactivation of C-fiber at higher dose. The activity can be attributed to the phyto-constituents viz tannins, diterpenes, triterpenes and steroids present in the DCHE extract. In conclusion, DCHE can be developed as a potent analgesic and anti-nociceptive agent in future.
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Assam, India.
authors.forename: Chandana Choudhury
authors.initials: CC
authors.lastname: Barua
authors.forename: Jayanti Datta
authors.initials: JD
authors.lastname: Roy
authors.forename: Bhaben
authors.initials: B
authors.lastname: Buragohain
authors.forename: Acheenta Gohain
authors.initials: AG
authors.lastname: Barua
authors.forename: Prabodh
authors.initials: P
authors.lastname: Borah
authors.forename: Mangala
authors.initials: M
authors.lastname: Lahkar