title: Incidence and prevalence of unrecognized myocardial infarction in people with diabetes: a substudy of the Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycemia in Diabetes (RECORD) study.
abstract: OBJECTIVE
  To examine the prevalence and incidence of unrecognized myocardial infarction in a contemporary population with type 2 diabetes.
  
  
  METHODS
  We performed a retrospective analysis of the electrocardiograms (ECGs) recorded at baseline and after 2 years for the first 1,004 type 2 diabetic individuals to be randomized in the Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycemia in Diabetes (RECORD) study.
  
  
  RESULTS
  ECGs suitable for analysis were obtained from 669 participants. The prevalence of unrecognized Q-wave myocardial infarction at baseline was 1.9% (n = 13). The incidence of unrecognized Q-wave myocardial infarction at the end of 2 years of follow-up was 1.5/1,000-person-years (n = 2). One-third (13 of 39) of prevalent and one-quarter (2 of 8) of incident myocardial infarctions were unrecognized.
  
  
  CONCLUSIONS
  Although the prevalence and incidence of myocardial infarction was low, unrecognized Q-wave myocardial infarctions made up a substantial proportion of all events.
authors.affiliation: Golden Jubilee National Hospital, Glasgow, UK. michael.macdonald@nhs.net
authors.forename: Michael R
authors.initials: MR
authors.lastname: MacDonald
authors.forename: Mark C
authors.initials: MC
authors.lastname: Petrie
authors.forename: Philip D
authors.initials: PD
authors.lastname: Home
authors.forename: Michel
authors.initials: M
authors.lastname: Komajda
authors.forename: Nigel P
authors.initials: NP
authors.lastname: Jones
authors.forename: Henning
authors.initials: H
authors.lastname: Beck-Nielsen
authors.forename: Ramon
authors.initials: R
authors.lastname: Gomis
authors.forename: Markolf
authors.initials: M
authors.lastname: Hanefeld
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Pocock
authors.forename: Paula S
authors.initials: PS
authors.lastname: Curtis
authors.forename: John J V
authors.initials: JJ
authors.lastname: McMurray
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D015994:Incidence; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000627:therapeutic use
chemical_list: D045162:Thiazolidinediones; D000077154:Rosiglitazone