title: The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes.
abstract: BACKGROUND
  Type 2 diabetes is mainly caused by insulin resistance. The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is an important candidate for causing insulin resistance.
  
  
  METHODS
  The CEACAM1 expression was evaluated immunohistochemically in the liver tissues of 99 severely obese or non-obese subjects with or without diabetes. The CEACAM1 expression was classified into two categories: a normal expression or a decreased expression.
  
  
  RESULTS
  The CEACAM1 expression was markedly decreased in the hepatocytes with macrovesicular steatosis. A decreased CEACAM1 expression was noted in 29 (29%) of 99 cases. The incidence of a decreased CEACAM1 expression was significantly higher in high grade fatty liver as well as severe obesity with or without diabetes (p < 0.05). The incidence of a decreased CEACAM1 expression was not different between the diabetic and non-diabetic groups.
  
  
  CONCLUSIONS
  This data supports that a decreased CEACAM1 expression is related to obesity and a fatty liver.
authors.affiliation: Department of Pathology, Dankook University College of Medicine, Cheonan, Korea. walee@dankook.ac.kr
authors.forename: Wonae
authors.initials: W
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D005234:Fatty Liver / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000378:metabolism* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; C069847:CD66 antigens; D015815:Cell Adhesion Molecules