title: Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals.
abstract: In addition to neutralization, antibodies mediate other antiviral activities including antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cellular cytotoxicity (ADCC), as well as complement deposition. While it is established that progressive HIV infection is associated with reduced ADCC and ADCP, the underlying mechanism for this loss of function is unknown. Here we report considerable changes in FcR expression over the course of HIV infection on both mDCs and monocytes, including elevated FcγRI expression in acute HIV infection and reduced expression of FcγRII and FcγRIIIa in chronic HIV infection. Furthermore, selective blockade of FcγRII alone was associated with a loss in ADCP activity, suggesting that FcγRII plays a central role in modulating ADCP. Overall, HIV infection is associated with a number of changes in FcR expression on phagocytic cells that are associated with changes in their ability to respond to antibody-opsonized targets, potentially contributing to a failure in viral clearance in progressive HIV-1 infection.
authors.affiliation: Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology (formerly known as Partners AIDS Research Center of Massachusetts General Hospital), Boston, MA, USA.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Dugast
authors.forename: Andrew
authors.initials: A
authors.lastname: Tonelli
authors.forename: Christoph T
authors.initials: CT
authors.lastname: Berger
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Ackerman
authors.forename: Gaia
authors.initials: G
authors.lastname: Sciaranghella
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Liu
authors.forename: Magdalena
authors.initials: M
authors.lastname: Sips
authors.forename: Ildiko
authors.initials: I
authors.lastname: Toth
authors.forename: Alicja
authors.initials: A
authors.lastname: Piechocka-Trocha
authors.forename: Musie
authors.initials: M
authors.lastname: Ghebremichael
authors.forename: Galit
authors.initials: G
authors.lastname: Alter
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity; D002908:Chronic Disease; D005260:Female; D015870:Gene Expression; D015658:HIV Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology* / Q000502:physiology; D006801:Humans; D056724:Immunity, Humoral; D007113:Immunity, Innate; D008297:Male; D010586:Phagocytes / Q000276:immunology*; D010587:Phagocytosis; D011961:Receptors, Fc / Q000235:genetics* / Q000276:immunology*
chemical_list: D011961:Receptors, Fc