title: Metabolomics, pathway regulation, and pathway discovery.
abstract: Metabolomics is a data-based research strategy, the aims of which are to identify biomarker pictures of metabolic systems and metabolic perturbations and to formulate hypotheses to be tested. It involves the assay by mass spectrometry or NMR of many metabolites present in the biological system investigated. In this minireview, we outline studies in which metabolomics led to useful biomarkers of metabolic processes. We also illustrate how the discovery potential of metabolomics is enhanced by associating it with stable isotopic techniques.
authors.affiliation: Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
authors.forename: Guo-Fang
authors.initials: GF
authors.lastname: Zhang
authors.forename: Sushabhan
authors.initials: S
authors.lastname: Sadhukhan
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Tochtrop
authors.forename: Henri
authors.initials: H
authors.lastname: Brunengraber
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D055442:Metabolome / Q000502:physiology*; D055432:Metabolomics / Q000379:methods* / Q000639:trends
chemical_list: D015415:Biomarkers