title: Effect of phytohemagglutinin on the growth of krebs-ii tumor-cells, body metabolism and internal organs of mice.
abstract: Neoplastic proliferation requires the availability of polyamines. Phytohaemagglutinin (PHA) is a potent growth factor which induces polyamine-dependent growth of the gut. In the hope of directing polyamines and other nutrients away from the tumour to the growing gut, mice fed PHA-containing or lactalbumin diets were injected intraperitoneally with Krebs II ascites cells and the number of tumour cells and the weights of internal organs were followed. PHA-treatment significantly slowed down the proliferation of tumour cells. Changes in the weight and polyamine content of tissues indicated that inter-organ competition between the tumour and vital organs can be used to manipulate the metabolism of tumour-bearing mice.
authors.affiliation: UNIV BERGEN,DEPT BIOCHEM & MOLEC BIOL,BERGEN,NORWAY.
authors.forename: S
authors.initials: S
authors.lastname: Bardocz
authors.forename: G
authors.initials: G
authors.lastname: Grant
authors.forename: A
authors.initials: A
authors.lastname: Pusztai
authors.forename: T
authors.initials: T
authors.lastname: Duguid
authors.forename: D
authors.initials: D
authors.lastname: Brown
authors.forename: I
authors.initials: I
authors.lastname: Pryme