title: Association between type 1 diabetes mellitus and deposits in the semicircular canals.
abstract: OBJECTIVE
  To compare the prevalence of cupular and free-floating deposits in the semicircular canals between temporal bones of type 1 diabetes mellitus patients and normal controls.
  
  
  METHODS
  Case-control histopathologic human temporal bone study.
  
  
  METHODS
  Otopathology laboratory in a tertiary academic medical center.
  
  
  METHODS
  Twenty-eight temporal bones from 14 patients with type 1 diabetes mellitus and 56 normal temporal bones from 28 age-matched individuals were histopathologically examined. The cupula and lumina of the semicircular canals were examined for evidence of deposits.
  
  
  RESULTS
  The prevalence of cupular and free-floating deposits in the lateral and posterior semicircular canals was significantly higher in type 1 diabetes mellitus patients compared with normal temporal bones (lateral, cupular deposits, odds ratio [OR], 5.47; 95% confidence interval [CI], 1.43 to 21.02; free-floating deposits, OR, 8.25; 95% CI, 2.42 to 27.85; posterior, cupular deposits, OR, 41.73; 95% CI, 5.96 to 275.50; free-floating deposits, OR, 7.44; 95% CI, 1.91 to 28.53). The prevalence of these deposits was associated with the duration of disease rather than with aging.
  
  
  CONCLUSIONS
  The findings suggest that type 1 diabetes mellitus is associated with cupular and free-floating deposits in the semicircular canals. The patients with type 1 diabetes mellitus with a longer duration of disease have an increased probability of suffering from benign paroxysmal positional vertigo.
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Yoda
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Cureoglu
authors.forename: Muzeyyen
authors.initials: M
authors.lastname: Yildirim-Baylan
authors.forename: Norimasa
authors.initials: N
authors.lastname: Morita
authors.forename: Hisaki
authors.initials: H
authors.lastname: Fukushima
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Harada
authors.forename: Michael M
authors.initials: MM
authors.lastname: Paparella
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D065635:Benign Paroxysmal Positional Vertigo; D002102:Cadaver; D002114:Calcinosis / Q000453:epidemiology / Q000473:pathology; D016022:Case-Control Studies; D015897:Comorbidity; D016001:Confidence Intervals; D003460:Crystallization; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D005547:Foreign Bodies / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010037:Otolithic Membrane / Q000473:pathology*; D015995:Prevalence; D012016:Reference Values; D018570:Risk Assessment; D012665:Semicircular Canals / Q000473:pathology*; D013701:Temporal Bone / Q000473:pathology*; D013997:Time Factors; D014717:Vertigo / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology*; D055815:Young Adult