title: Prognostic significance of p63, p53 and ki67 expression in laryngeal basaloid squamous cell carcinomas.
abstract: BACKGROUND
  It is well known that basaloid squamous call carcinoma (BSCC) is more aggressive than the usual form of squamous cell carcinoma. However, current information about the prognostic significance of basaloid squamous cell carcinoma in the larynx is sparse. We investigated p63, p53 and Ki67 in BSCC of the larynx.
  
  
  METHODS
  In a retrospective study conducted from January 2000 to June 2006, we used immunohistochemistry to analyse the protein expression of p63, p53, and Ki-67 in paraffin-embedded tumour samples from 22 BSCC patients and compared the clinicopathological parameters with the survival outcome.
  
  
  RESULTS
  Positive p63 expression was found in 16 of 22 BSCC specimens (72.7%). Expression was higher in cases without lymph node metastasis than in cases with lymph node metastasis. This investigation found an inverse correlation between the expression of p63 and lymph node status in BSCC.
  
  
  CONCLUSIONS
  To our knowledge, this is the first clinical study of p63 expression in laryngeal BSCC.
authors.affiliation: Department of Head and Neck Surgery, Izmir Training and Research Hospital, Izmir, Turkey. caglarcalli@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: Calli
authors.forename: A
authors.initials: A
authors.lastname: Calli
authors.forename: E
authors.initials: E
authors.lastname: Pinar
authors.forename: S
authors.initials: S
authors.lastname: Oncel
authors.forename: B
authors.initials: B
authors.lastname: Tatar
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C081876:CKAP4 protein, human; D019394:Ki-67 Antigen; D008565:Membrane Proteins; D016159:Tumor Suppressor Protein p53