title: Effect of Coordination on the Glucose-Responsiveness of PEG-b-(PAA-co-PAAPBA) Micelles.
abstract: Poly(ethylene glycol)-block-poly(acrylic acid) (PEG-PAA) is modified by 3-aminophenylboronic acid (APBA) with different modification degrees, such as PEG(114) -b-(PAA(0.37) -co-PAAPBA(0.63) )(170) , PEG(114) -b-(PAA(0.23) -co-PAAPBA(0.77) )(170) and PEG(114) -b-(PAA(0.02) -co-PAAPBA(0.98) )(170) . Micelles self-assembled from these three copolymers possess glucose-responsiveness at varying pH values. Micelles self-assembled from PEG(114) -b-(PAA(0.37) -co-PAAPBA(0.63) )(170) have glucose-responsiveness at the physiological pH (7.4), endowing them with potential applications in the treatment of diabetes. (11) B magic-angle spinning nuclear magnetic resonance ((11) B MAS NMR) analysis indicates that interactions between PAAPBA segments and PAA segments induce boron changes from the trigonal planar form to the tetrahedral form, resulting in glucose-responsiveness of PEG(114) -b-(PAA(0.37) -co-PAAPBA(0.63) )(170) micelles at pH 7.4.
authors.affiliation: Key Laboratory of Functional Polymer Materials, Ministry of Education, and Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Beilei
authors.initials: B
authors.lastname: Wang
authors.forename: Rujiang
authors.initials: R
authors.lastname: Ma
authors.forename: Gan
authors.initials: G
authors.lastname: Liu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Liu
authors.forename: Yaohua
authors.initials: Y
authors.lastname: Gao
authors.forename: Junyang
authors.initials: J
authors.lastname: Shen
authors.forename: Yingli
authors.initials: Y
authors.lastname: An
authors.forename: Linqi
authors.initials: L
authors.lastname: Shi