title: [Distributions and spreads of antimicrobial drug-resistant microorganisms in Saga prefecture].
abstract: We investigated the distribution of drug-resistant organisms to clarify transmission of the organisms. Drug-resistant organisms were surveyed in 12 facilities in 4 districts of Saga prefecture for 2 years, and were analyzed by beta-lactamase typing, antimicrobial susceptibility tests and pulsed-field gel electrophoresis (PFGE). The number of isolates was 111,505 for the 2 years. Questionnaires for drug-resistant organisms revealed that Methicillin-resistant Staphylococcus aureus (MRSA) was 64.1% of S. aureus, penicillin-intermediate Streptococcus pneumoniae (PISP) or penicillin-resistant S. pneumoniae (PRSP) 60.1% of S. pneumoniae, beta-lactamase-negative ampicillin-resistent Haemophilus inflluenzae (BLNAR) 19.4% of H. influenzae, Metallo-beta-Lactamase (MBL) 0.1% of gram-negative bacilli, multi-drug resistant Pseudomonas aeruginosa (MDRP) 0.6% of P. aeruginosa and extended-spectrum beta-lactamase (ESBL) producing organisms 8.0% and 3.1% of Escherichia coli and Klebsiella pneumoniae, respectively. PFGE analysis of ESBL E. coli revealed that 33 isolates collected from 7 facilities in 3 districts belonged to the same one group, indicating that this strain is transferred between different hospitals in different saga districts. Investigations of distribution of drug-resistant organisms in not only each hospitals but also in the first and the second medical areas are important for controls of healthcare-associated infections and antibiotic prescriptions.
authors.affiliation: Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan. kiyosuke@med.kyushu-u.ac.jp
authors.forename: Makiko
authors.initials: M
authors.lastname: Kiyosuke
authors.forename: Masaki
authors.initials: M
authors.lastname: Nagata
authors.forename: Zenzo
authors.initials: Z
authors.lastname: Nagasawa
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Kayamori
authors.forename: Dongchon
authors.initials: D
authors.lastname: Kang
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyamoto
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D003428:Cross Infection / Q000382:microbiology* / Q000517:prevention & control*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006268:Health Facilities; D006306:Health Surveys; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents