title: Nonrandom secondary chromosome-aberrations in liposarcomas with t(12, 16).
abstract: Ten liposarcomas were analyzed cytogenetically after short-term culturing. Eight tumors had a t(12;16) (q13;p11) and two tumors had complex translocations involving chromosomes 7, 12, and 16 and 2, 9, 12, 16 and 20, respectively. Among the secondary aberrations seen in five tumors, +8 was found in two tumors and i(7)(q10) in four tumors. Trisomy 8 has previously been described as a nonrandom secondary aberration in myxoid liposarcoma, but i(7q) has only been reported in a single case before. All recurrent chromosome aberrations reported in liposarcomas with recombination between 12q13 and 16p11 (42 cases) were surveyed and compared with their frequencies in liposarcomas without this recombination (33 cases). Trisomy 5 and 8 were found in both tumor groups, whereas +19, t(3;15)(p23;q15), del(6)(q21), i(7q), and rearrangements of 1p11 and 2q35 were found exclusively in tumors with 12q13 and 16p11 aberrations.
authors.affiliation: UNIV LUND HOSP,DEPT ORTHOPED SURG,S-22185 LUND,SWEDEN. UNIV LUND HOSP,DEPT CLIN PATHOL,S-22185 LUND,SWEDEN. KAROLINSKA HOSP,DEPT ORTHOPED,TUMOR SERV,S-10401 STOCKHOLM 60,SWEDEN.
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: F
authors.initials: F
authors.lastname: Mertens
authors.forename: P
authors.initials: P
authors.lastname: Aman
authors.forename: A
authors.initials: A
authors.lastname: Rydholm
authors.forename: O
authors.initials: O
authors.lastname: Brosjo
authors.forename: H
authors.initials: H
authors.lastname: Willen
authors.forename: F
authors.initials: F
authors.lastname: Mitelman