title: Inflammatory bowel disease.
abstract: This review focuses on the prominent etiological and pathogenetic aspects of inflammatory bowel disease (IBD), with particular attention being paid to the mucosal immune response to commensal micro-organisms in health and disease. Pathogenetic implications for target therapy will also be discussed. The clinical presentation, diagnostic aspects, and currently recommended therapeutic options for the two main types of IBD are also taken into consideration, including manifestations of these conditions in the oral cavity.
authors.affiliation: Immune-mediated Disease Section, Department of Infectious, Parasitic and Immune-mediated Disease, Istituto Superiore di Sanità, Roma, Italy. monica.boirivant@iss.it
authors.forename: M
authors.initials: M
authors.lastname: Boirivant
authors.forename: A
authors.initials: A
authors.lastname: Cossu
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy; D003424:Crohn Disease / Q000175:diagnosis / Q000188:drug therapy; D016207:Cytokines / Q000096:biosynthesis; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000235:genetics / Q000276:immunology* / Q000382:microbiology*; D007413:Intestinal Mucosa / Q000382:microbiology; D009059:Mouth Diseases / Q000209:etiology; D012074:Remission Induction
chemical_list: D000911:Antibodies, Monoclonal; D016207:Cytokines; D007155:Immunologic Factors