title: Signalling mechanisms in Mycobacteria.
abstract: The importance of inter- and intracellular signal transduction in all forms of life cannot be underestimated. A large number of genes dedicated to cellular signalling are found in almost all sequenced genomes, and Mycobacteria are no exception. What appears to be interesting in Mycobacteria is that well characterized signalling mechanisms used by bacteria, such as the histidine-aspartate phosphorelay seen in two-component systems, are found alongside signalling components that closely mimic those seen in higher eukaryotes. This review will describe the important contribution made by researchers in India towards the identification and characterization of proteins involved in two-component signalling, protein phosphorylation and cyclic nucleotide metabolism.
authors.affiliation: Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India. pradip@imtech.res.in
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Chakraborti
authors.forename: Nishad
authors.initials: N
authors.lastname: Matange
authors.forename: Vinay K
authors.initials: VK
authors.lastname: Nandicoori
authors.forename: Yogendra
authors.initials: Y
authors.lastname: Singh
authors.forename: Jaya S
authors.initials: JS
authors.lastname: Tyagi
authors.forename: Sandhya S
authors.initials: SS
authors.lastname: Visweswariah
mesh_terms: D035843:Biomedical Research; D006801:Humans; D007194:India; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D017346:Protein Serine-Threonine Kinases