title: Livedo reticularis: a side effect of interferon therapy in a pediatric patient with melanoma.
abstract: Livedo reticularis is a lacy mottling of the skin that can have many etiologies. We report a case of an 8-year-old boy with a diagnosis of melanoma who developed persistent livedo reticularis during treatment with interferon alpha-2B. To our knowledge, this is the first case report of livedo reticularis occurring as a side effect of interferon treatment for pediatric melanoma. Given the increasing incidence of pediatric melanoma, it is important that dermatologists be aware of potential side effects of interferon therapy to optimize care and education for these patients.
authors.affiliation: Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Fox
authors.forename: Steven
authors.initials: S
authors.lastname: Tahan
authors.forename: Caroline C
authors.initials: CC
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D054068:Livedo Reticularis / Q000209:etiology* / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins