title: Differential characteristics of inflammatory responses to stent implantation between de novo and intrastent restenosis lesion in patients with stable angina.
abstract: Mechanical plaque rupture of coronary atherosclerotic plaque during stent implantation can increase serum levels of high-sensitivity C-reactive protein (hsCRP). Patients with stable angina pectoris were divided into 2 groups: one group included 186 patients with de novo lesion who underwent stent implantation (de novo group); the other group included 40 patients with intrastent restenosis (ISR) undergoing stent implantation (ISR group). The de novo group had a significant increase in hsCRP levels post stenting, while the ISR group showed no increase in hsCRP post stenting. Intravascular ultrasound with radiofrequency data analysis showed that the de novo group had larger percentage of both necrotic core area and fibrofatty area at the target lesion than the ISR group, while the ISR group had a larger percentage of fibrous area. Differential inflammatory response to stent implantation between the de novo plaque and in ISR lesion is related to lesion morphology.
authors.affiliation: Yokosuka Kyosai Hospital, 1-16 Yonegahama-dori, Yokosuka, Kanagawa, Japan. hhikita-circ@umin.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hikita
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kuroda
authors.forename: Naohiko
authors.initials: N
authors.lastname: Kawaguchi
authors.forename: Emiko
authors.initials: E
authors.lastname: Nakashima
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fujinami
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kamiishi
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nozato
authors.forename: Taishi
authors.initials: T
authors.lastname: Kuwahara
authors.forename: Akira
authors.initials: A
authors.lastname: Satoh
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Isobe
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000150:complications; D002097:C-Reactive Protein / Q000032:analysis*; D023903:Coronary Restenosis / Q000097:blood / Q000150:complications / Q000601:surgery; D023921:Coronary Stenosis / Q000097:blood* / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015607:Stents
chemical_list: D002097:C-Reactive Protein