title: [Cancer stem cells and future therapeutic implications].
abstract: A growing body of evidence indicates that a subpopulation of tumor cells, the so-called cancer stem cells (CSCs), drive tumor growth and metastasis and preclude therapy efficiency. CSCs have been isolated in virtually all type of tumors. These findings may have important consequences for clinical prognostic. Current cancer research aims to unravel the CSCs' unique biological mechanisms. The development of new CSCs-targeted treatments shed therefore new hopes in improving cancer therapy.
authors.affiliation: Laboratory for experimental oncology and radiobiology, Center for experimental molecular medicine, Academic medical center, University of Amsterdam, The Netherlands. f.desousaemelo@amc.uva.nl
authors.forename: F
authors.initials: F
authors.lastname: de Sousa E Melo
authors.forename: I
authors.initials: I
authors.lastname: Guessous
authors.forename: L
authors.initials: L
authors.lastname: Vermeulen
authors.forename: J P
authors.initials: JP
authors.lastname: Medema
mesh_terms: D005544:Forecasting; D006801:Humans; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D014411:Neoplastic Stem Cells