title: Histological assessments for toxicity and functionalization-dependent biodistribution of carbon nanohorns.
abstract: Single-walled carbon nanohorns (SWNHs) intravenously administered to mice did not show severe toxicity during a 26-week test period, which was confirmed by normal gross appearance, normal weight gain and the lack of abnormality in the tissues on histological observations of the mice. SWNH biodistribution was influenced by chemical functionalization. Accumulation of SWNH in the lungs reduced as SWNH hydrophilicity increased; however, the most hydrophilic SWNHs modified with bovine serum albumin (BSA) were most likely to be trapped in the lungs, suggesting that the BSA moiety enhanced macrophage phagocytosis in the lungs. Clearance of some of the hydrophobic SWNHs from the lungs was observed, the mechanism of which is briefly discussed.
authors.affiliation: Nanotube Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tahara
authors.forename: Jin
authors.initials: J
authors.lastname: Miyawaki
authors.forename: Minfang
authors.initials: M
authors.lastname: Zhang
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.forename: Iwao
authors.initials: I
authors.lastname: Waga
authors.forename: Sumio
authors.initials: S
authors.lastname: Iijima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Irie
authors.forename: Masako
authors.initials: M
authors.lastname: Yudasaka
mesh_terms: D000818:Animals; D002417:Cattle; D006861:Hydrogen Peroxide / Q000378:metabolism; D007150:Immunohistochemistry; D008027:Light; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D037742:Nanotubes, Carbon / Q000032:analysis* / Q000633:toxicity* / Q000648:ultrastructure; D009928:Organ Specificity / Q000187:drug effects* / Q000528:radiation effects; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D014018:Tissue Distribution / Q000187:drug effects / Q000528:radiation effects
chemical_list: D037742:Nanotubes, Carbon; D012710:Serum Albumin, Bovine; D006861:Hydrogen Peroxide