title: Expression of nm23-h1 gene in squamous-cell carcinoma of the cervix correlates with 5-year survival.
abstract: We have examined nm23-H1 protein levels in human squamous cell carcinoma of the cervix by immunohistochemistry and correlated detectable nm23-H1 with patient survival. Normal cervical tissue samples were consistently strongly immunoreactive. In contrast, cervical carcinomas stained poorly, if at all. Well differentiated carcinomas stained more frequently for nm23-H1 protein than poorly or undifferentiated carcinomas. Our results clearly demonstrated a significant correlation between absence of nm23-H1 protein staining and shorter survival of patients with cervical cancer. Our results suggest that nm23 may serve as a potentially valuable prognostic marker for this type of tumor and to our knowledge is the first report of this kind for cervical carcinoma.
authors.affiliation: UNIV CINCINNATI,COLL MED,DEPT OTOLARYNGOL HEAD & NECK SURG,DIV MOLEC ONCOL,CINCINNATI,OH 45267. UNIV ZAGREB,SVITI DUH GEN HOSP,SCH MED,DEPT OBSTET & GYNECOL,ZAGREB 41001,CROATIA. RUDJER BOSKOVIC INST,DEPT MOLEC MED,ONCOL MOLEC LAB,ZAGREB,CROATIA. UNIV HOSP TUMORS,ZAGREB,CROATIA. UNIV CINCINNATI,COLL MED,DEPT CELL BIOL NEUROBIOL & ANAT,CINCINNATI,OH 45267.
authors.forename: M
authors.initials: M
authors.lastname: Ilijas
authors.forename: K
authors.initials: K
authors.lastname: Pavelic
authors.forename: B
authors.initials: B
authors.lastname: Sarcevic
authors.forename: S
authors.initials: S
authors.lastname: Kapitanovic
authors.forename: A
authors.initials: A
authors.lastname: Kurjak
authors.forename: P
authors.initials: P
authors.lastname: Stambrook
authors.forename: J
authors.initials: J
authors.lastname: Gluckman
authors.forename: Z
authors.initials: Z
authors.lastname: Pavelic