title: [Visual imaging for buccal carcinoma with near-infrared fluorescent quantum dots in vivo].
abstract: OBJECTIVE
  To examine the in vivo visual imaging of buccal carcinoma with the near-infrared fluorescent quantum dots.
  
  
  METHODS
  The U14 cells were labeled by endocytosis with QD800 (U14/QD800) which was linked with cell-penetrating peptide. Different number of U14/QD800 was injected under the buccal mucosa of nude mice and Kunming mice separately and imaged at different time to detect the in vivo sensitivity and dynamic imaging of U14/QD800.
  
  
  RESULTS
  The minimum number of U14/QD800 cells which could be detected by in vivo imaging system was 1 × 10(4) in nude mice's cheek and 1 × 10(5) in Kunming mice's. The time for visual imaging of 1 × 10(4), 1 × 10(5) and 1 × 10(6) U14/QD800 cells in nude mice was 3, 7 and 16 d separately, and 3 and 10 d separately in Kunming mice.
  
  
  CONCLUSIONS
  Due to its strong tissue penetration, near-infrared fluorescent quantum dots have great prospects in cancer early diagnosis, visual observation and individual treatment.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. cqfyyk@yahoo.com.cn
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.forename: Yu-an
authors.initials: YA
authors.lastname: Cao
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Li
authors.forename: Xiao-qiang
authors.initials: XQ
authors.lastname: Lü
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhao
authors.forename: Jia
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology; D045744:Cell Line, Tumor; D002610:Cheek / Q000473:pathology; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D057054:Molecular Imaging / Q000379:methods; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009368:Neoplasm Transplantation; D045663:Quantum Dots; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000473:pathology