title: Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats.
abstract: OBJECTIVE
  To assess the anticataleptic and antiepileptic activity of leaves of Mucuna pruriens in albino rats.
  
  
  METHODS
  Haloperidol-induced catalepsy (HIC), maximum electro-shock (MES) method, pilocarpine-induced Status epilepticus (PISE) and single-dose effect of M. pruriens were employed.
  
  
  RESULTS
  M. pruriens (100 mg/kg) had significant anticataleptic and antiepileptic activity in HIC, MES, and PISE.
  
  
  CONCLUSIONS
  M. pruriens extract has the potential to be an anticataleptic and antiepileptic drug. Dopamine and 5-HT may have a role in such activity.
authors.affiliation: Department of Pharmacology, University Department of Pharmaceutical Sciences, Bhubaneswar-751 004, Orissa, India.
authors.forename: D
authors.initials: D
authors.lastname: Champatisingh
authors.forename: P K
authors.initials: PK
authors.lastname: Sahu
authors.forename: A
authors.initials: A
authors.lastname: Pal
authors.forename: G S
authors.initials: GS
authors.lastname: Nanda