title: Penetration of ertapenem into muscle measured by in vivo microdialysis in mechanically ventilated patients.
abstract: Ertapenem at 1 g once daily has been suggested to be underdosed in intensive care unit (ICU) patients to attain optimal concentrations in target tissues. Therefore, our study aimed to assess the kinetics of ertapenem in plasma and skeletal muscle in ICU patients using microdialysis. Average muscle free-ertapenem concentrations were above the MIC values of targeted pathogens. In a few patients, the concentrations were below the MIC values. The clinical efficiency of ertapenem at 1 g once daily should be evaluated in a large population of ICU patients.
authors.affiliation: 1Service d'anesthésie et de réanimation, Hôpital Nord, Assistance Publique—Hôpitaux de Marseille, Université de la Méditerranée, 13015 Marseille, France.
authors.forename: I
authors.initials: I
authors.lastname: Boyadjiev
authors.forename: A
authors.initials: A
authors.lastname: Boulamery
authors.forename: N
authors.initials: N
authors.lastname: Simon
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: B
authors.initials: B
authors.lastname: Bruguerolle
authors.forename: M
authors.initials: M
authors.lastname: Leone
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D000077727:Ertapenem; D005260:Female; D006801:Humans; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D012121:Respiration, Artificial; D047090:beta-Lactams / Q000493:pharmacokinetics* / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D000077727:Ertapenem