title: Increased serum nitric oxide metabolites in dysglycaemia.
abstract: BACKGROUND
  Nitric oxide plays an important role in hyperglycaemia-induced endothelial dysfunction.
  
  
  OBJECTIVE
  To investigate the relationship between serum nitric oxide metabolite (NO(x)) levels and fasting glucose in a population-based study.
  
  
  METHODS
  Serum concentration of NO(x) was measured by the Griess method in 3,505 participants, aged 20-94 years, selected from a population-based study.
  
  
  RESULTS
  In men with impaired fasting glucose, each mmol/L increase in fasting serum glucose increased probability of serum NO(x) levels higher than median (> 25 μM) by 3.05-times (OR = 3.05 [95% CI, 1.15-8.07], p = 0.025) in non-adjusted and 3.76-times (OR = 3.76 [95% CI, 1.34-10.53, p = 0.012) in multivariable-adjusted analyses, while no significant associations were found in women. A direct association between fasting glucose categories and NO(x) values was found in men after multivariable adjustment (p = 0.006). Multivariable-adjusted serum NO(x) was significantly (p = 0.008) higher in diabetic men [34.1 (29.5-39.6) μmol/L] compared to non-diabetic ones [29.7 (26.5-33.2) μmol/L].
  
  
  CONCLUSIONS
  The findings show increased serum NO(x) levels in men, but not women, with impaired fasting glucose and diabetes in a population-based study.
authors.affiliation: Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Asghar
authors.initials: A
authors.lastname: Ghasemi
authors.forename: Saleh
authors.initials: S
authors.lastname: Zahediasl
authors.forename: Iraj
authors.initials: I
authors.lastname: Azimzadeh
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009569:Nitric Oxide / Q000097:blood*; D016017:Odds Ratio; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D009569:Nitric Oxide