title: APACHE II scoring system is superior in the prediction of the outcome in critically ill patients with perforative peritonitis.
abstract: BACKGROUND
  There are several scoring systems used in the prediction of outcome in critically ill patients. This study was undertaken to evaluate APACHE II, SAPS I, Sepsis score, MOF, TISS-28 and MPI scoring systems in prediction of the outcome in patients with perforative peritonitis.
  
  
  METHODS
  The prospective study of 145 patients of both sexes with perforative peritonitis was performed. The main outcome of study was peritonitis-related death. Variables necessary for calculation of the scoring systems were recorded at the initial admission to the hospital and the third and seventh day of hospitalization, except Mannheim Peritonitis Index, which was calculated during the first 24 hours after hospitalization. Cut-off points were specified and all values greater than cut-off points were taken to predict death. Sensitivity and specificity are graphically shown for the different values of cut-off points and represented with the receiver-operating characteristic curve. The difference in the area below the curve between scoring systems was statistically compared.
  
  
  RESULTS
  The area under the curve for the first postoperative day was 0.87 for TISS-28 score, 0.86 for APACHE II score, 0.83 for MOF and SAPS I, 0.72 for MPI and 0.70 for Sepsis score. This demonstrated that TISS-28 and APACHE II are significantly better than other systems (p < 0.01). In addition, this discriminatory ability remained on the third and seventh postoperative day as well. The highest rate of correlation between the observed and the expected mortality rate for the first (Kendall's tau correlation 0.964) and the third day (Kendall's ścorrelation 0.810) was in APACHE II system.
  
  
  CONCLUSIONS
  APACHE II is superior in prediction of the outcome to other tested scoring systems.
authors.affiliation: Department of Surgery, University Clinic Center Tuzla, University of Tuzla, Bosnia and Herzegovina.
authors.forename: Samir
authors.initials: S
authors.lastname: Delibegovic
authors.forename: Dragana
authors.initials: D
authors.lastname: Markovic
authors.forename: Samir
authors.initials: S
authors.lastname: Hodzic
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D016638:Critical Illness / Q000145:classification*; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000145:classification* / Q000401:mortality / Q000601:surgery; D011379:Prognosis; D012372:ROC Curve; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult