title: Rasburicase improves hyperuricemia in patients with acute kidney injury secondary to rhabdomyolysis caused by ecstasy intoxication and exertional heat stroke.
abstract: OBJECTIVE
  To report the successful use of rasburicase in two children with hyperuricemia secondary to severe rhabdomyolysis.
  
  
  METHODS
  : Case report.
  
  
  METHODS
  Pediatric intensive care unit in a freestanding quaternary hospital.
  
  
  METHODS
  Two pediatric patients with severe rhabdomyolysis and hyperuricemia caused by ecstasy intoxication and exertional heat stroke.
  
  
  METHODS
  Use of a single low dose (6 mg) of rasburicase, a urate oxidase enzyme.
  
  
  RESULTS
  Rasburicase was administered on the first and second hospital days with a single low dose of 6 mg (0.086 mg/kg in patient A and 0.092 mg/kg in patient B). Within 24 hrs, the levels of serum uric acid in both patients decreased dramatically, and their creatinine levels decreased and urine output increased concurrently. Continuous improvements in the uric acid levels, creatinine levels, and urine output were noted during hospitalization.
  
  
  CONCLUSIONS
  Rasburicase seems to be a safe and effective drug for improving hyperuricemia in patients with rhabdomyolysis and renal failure.
authors.affiliation: Department of Pediatrics, Mackay Memorial Hospital, Taiwan.
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Lin
authors.forename: Chun-Chen
authors.initials: CC
authors.lastname: Lin
authors.forename: Hsi-Che
authors.initials: HC
authors.lastname: Liu
authors.forename: Ming-Dar
authors.initials: MD
authors.lastname: Lee
authors.forename: Hung-Chang
authors.initials: HC
authors.lastname: Lee
authors.forename: Che-Sheng
authors.initials: CS
authors.lastname: Ho
authors.forename: Nan-Chang
authors.initials: NC
authors.lastname: Chiu
authors.forename: Chun-Chih
authors.initials: CC
authors.lastname: Peng
authors.forename: Fu-Yuan
authors.initials: FY
authors.lastname: Huang
authors.forename: Jeng-Daw
authors.initials: JD
authors.lastname: Tsai
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D002648:Child; D005260:Female; D006074:Gout Suppressants / Q000008:administration & dosage / Q000627:therapeutic use*; D006213:Hallucinogens / Q000506:poisoning*; D018883:Heat Stroke / Q000150:complications*; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy*; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000506:poisoning*; D005082:Physical Exertion / Q000502:physiology*; D012206:Rhabdomyolysis / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D013624:Taiwan; D014503:Urate Oxidase / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D006074:Gout Suppressants; D006213:Hallucinogens; C469709:rasburicase; D014503:Urate Oxidase; D018817:N-Methyl-3,4-methylenedioxyamphetamine