title: [Spontaneous hematomas and isolated prolongation of aPTT].
abstract: We report a case of a 64 year old woman with spontaneous hematomas. A prior history of bleeding disorder was not known up to now. The result of investigation of coagulation was an isolated prolonged aPTT that was caused by an inhibitor of factor VIII without underlying disease (idiopathic acquired hemophilia A). Therapy with steroids and cyclophosphamid resulted in partial remission.
authors.affiliation: Universitätsklinik für Allgemeine Innere Medizin, Inselspital, Universitätsspital Bern, Freiburgstrase 10, 3010 Bern. andres.oestmann@insel.ch
authors.forename: B
authors.initials: B
authors.lastname: Heimgartner
authors.forename: A
authors.initials: A
authors.lastname: Oestmann
authors.forename: P
authors.initials: P
authors.lastname: Keller
authors.forename: I
authors.initials: I
authors.lastname: Rüsges-Wolter
mesh_terms: D000465:Algorithms; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005260:Female; D006406:Hematoma / Q000097:blood* / Q000188:drug therapy / Q000209:etiology*; D006467:Hemophilia A / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D006474:Hemorrhagic Disorders / Q000097:blood* / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D005169:Factor VIII; D011239:Prednisolone; D008775:Methylprednisolone