title: 4-Des-oxy-4β-[(5-meth-oxy-1H-indol-3-yl)oxalylamino]podophyllotoxin methanol solvate.
abstract: The main mol-ecule of the title solvate, C(33)H(30)N(2)O(10)·CH(3)OH, is a new anti-tumor agent, which shows cytotoxicity against MDR cancer cell lines. It has been synthesized by coupling 4β-amino-podophyllotoxin with (5-meth-oxy-1H-indol-3-yl)glyoxyl chloride and structurally characterized. There are two crystallographically independent mol-ecules in the asymmetric unit, which differ in the dihedral angles between the aromatic rings. The dihedral angles between the benzene ring of the benzo[d][1,3]dioxole and the benzene ring of the 5-meth-oxy-1H-indole are 85.08 (3) and 76.88 (3)° and reflect the main conformational difference between the two independent mol-ecules. The asymmetric unit is completed with two methanol solvent mol-ecules, one of which is disordered over two positions, with occupancies close to 0.5.
authors.forename: Min
authors.initials: M
authors.lastname: Feng
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Jingze
authors.initials: J
authors.lastname: Zhang
authors.forename: Zaixin
authors.initials: Z
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen