title: Practical vascular anatomy in the preparation of radioembolization.
abstract: As the incidence of primary and metastatic liver cancer continues to increase, the use of minimally invasive techniques as a treatment option is becoming more common. Radioembolization, a form of intra-arterial brachytherapy, is a technique where particles of glass or resin, impregnated with the isotope 90yttrium (90Y), are infused through a catheter directly into the hepatic arteries. This modality is based on the fact that hepatic malignancies receive their blood supply from the hepatic artery, whereas normal hepatocytes are perfused mostly from the portal circulation, which allows delivery of high doses to the tumor vasculature with relative sparing of normal liver tissue. This has been shown to be effective for both primary and metastatic tumors. A variety of complications may be related to hepatic intra-arterial treatments, especially to the gastroduodenal region. These complications are known to come from inadvertent extrahepatic infusion of 90Y particles, through arteries originating from the hepatic arterial branches such as the falciform artery, cystic artery, arteries from the pancreaticoduodenal arcade, gastroduodenal artery, or right gastric artery. Surgeons and interventional radiologists rely on accurate imaging and assessment of the hepatic arterial supply. It is important to know the common anatomic variations and technical considerations before radioembolization. We recommend an aggressive occlusion of all the above-mentioned arteries; further, clinicians should watch out for any other aberrant branches, and if in doubt, they ought to be coiled.
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilians-University, University of Munich, Campus Grosshadern, Marchioninistrasse 15, Munich, Germany. philipp.paprottka@med.uni-muenchen.de
authors.forename: P M
authors.initials: PM
authors.lastname: Paprottka
authors.forename: T F
authors.initials: TF
authors.lastname: Jakobs
authors.forename: M F
authors.initials: MF
authors.lastname: Reiser
authors.forename: R T
authors.initials: RT
authors.lastname: Hoffmann
mesh_terms: D000792:Angiography; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000517:prevention & control; D006801:Humans; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000532:radiotherapy*; D008863:Microspheres; D015641:Radiography, Interventional; D015021:Yttrium Radioisotopes / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D015021:Yttrium Radioisotopes