title: Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?
abstract: Chromatin-modifying enzymes are known to be critical components for the correct differentiation of embryonic stem cells into specific lineages, such as neurons. Recently, the role of Polycomb group proteins has been studied in the specification and differentiation of muscle stem cells. In this perspective, we review a recent study by Juan and colleagues (pp. 789-794) in Genes & Development of the role of the polycomb group protein Ezh2 in muscle stem cells, and discuss the implications for general lineage restriction.
authors.affiliation: Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Conerly
authors.forename: Kyle L
authors.initials: KL
authors.lastname: MacQuarrie
authors.forename: Abraham P
authors.initials: AP
authors.lastname: Fong
authors.forename: Zizhen
authors.initials: Z
authors.lastname: Yao
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Tapscott
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004330:Drosophila; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000166:cytology* / Q000378:metabolism*; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D063146:Polycomb-Group Proteins; D012097:Repressor Proteins; D014157:Transcription Factors