title: New and old monoclonal antibodies for the treatment of chronic lymphocytic leukemia.
abstract: Over the last few years, several new agents have been under evaluation in preclinical studies and clinical trials, showing promise in treating chronic lymphocytic leukemia (CLL). Among these agents, monoclonal antibodies (mAbs) such as rituximab and alemtuzumab have changed the natural course of the disease. Nowadays there are several new promising monoclonal antibodies under investigation against the CD20, CD23, CD37 and CD40 molecules. Application of newer monoclonal antibodies represents an area of ongoing clinical research in CLL.
authors.affiliation: Hematology Department, Catholic University of Sacred Hearth, Largo Agostino Gemelli, 00168 Rome, Italy. l.laurenti@rm.unicatt.it
authors.forename: L
authors.initials: L
authors.lastname: Laurenti
authors.forename: L
authors.initials: L
authors.lastname: De Padua
authors.forename: G
authors.initials: G
authors.lastname: D'Arena
authors.forename: B
authors.initials: B
authors.lastname: Vannata
authors.forename: I
authors.initials: I
authors.lastname: Innocenti
authors.forename: M
authors.initials: M
authors.lastname: Tarnani
authors.forename: S
authors.initials: S
authors.lastname: Deaglio
authors.forename: S
authors.initials: S
authors.lastname: Sica
authors.forename: D G
authors.initials: DG
authors.lastname: Efremov
authors.forename: G
authors.initials: G
authors.lastname: Leone
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D015703:Antigens, CD / Q000737:chemistry / Q000378:metabolism; D018951:Antigens, CD20 / Q000737:chemistry / Q000378:metabolism; D000951:Antigens, Neoplasm / Q000737:chemistry / Q000378:metabolism; D000970:Antineoplastic Agents / Q000276:immunology / Q000627:therapeutic use*; D019013:CD40 Antigens / Q000037:antagonists & inhibitors / Q000378:metabolism; D000074301:CD52 Antigen; D006023:Glycoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy*; D017455:Receptors, IgE / Q000037:antagonists & inhibitors / Q000378:metabolism; D059470:Tetraspanins
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018951:Antigens, CD20; D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; C059071:CD37 protein, human; D019013:CD40 Antigens; D000074301:CD52 Antigen; C000613862:CD52 protein, human; D006023:Glycoproteins; D017455:Receptors, IgE; D059470:Tetraspanins