title: The imprint of codons on protein structure.
abstract: The "central dogma" of biology outlines the unidirectional flow of interpretable data from genetic sequence to protein sequence. This has led to the idea that a protein's structure is dependent only on its amino acid sequence and not its genetic sequence. Recently, however, a more than transient link between the coding genetic sequence and the protein structure has become apparent. The two interact at the ribosome via the process of co-translational protein folding. Evidence for co-translational folding is growing rapidly, but the influence of codons on the protein structure attained is still highly contentious. It is theorised that the speed of codon translation modulates the time available for protein folding and hence the protein structure. Here, past and present research regarding synonymous codons and codon translation speed are reviewed within the context of protein structure attainment.
authors.affiliation: Department of Statistics, Oxford University, Oxford, UK. deane@stats.ox.ac.uk
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Deane
authors.forename: Rhodri
authors.initials: R
authors.lastname: Saunders
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003062:Codon / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D014176:Protein Biosynthesis; D017510:Protein Folding; D017433:Protein Structure, Secondary / Q000502:physiology*; D017434:Protein Structure, Tertiary / Q000502:physiology*; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D003062:Codon; D011506:Proteins; D012343:RNA, Transfer