title: Anti-inflammatory effect of the ethanolic extract from Bowdichia virgilioides H.B.K stem bark.
abstract: Bowdichia virgilioides H.B.K stem bark (Fabaceae), locally known as "sucupira-preta", is a reputed folk-remedy to treat some inflammatory disorders. To validate its traditional claim, the ethanolic extract from B. virgilioides was evaluated in several animal models of inflammation and nociception. The extract at oral doses of 100 to 1000 mg/kg body weight caused a significant inhibition of carrageenan-induced hind paw oedema, suppression of exudate volume and leukocyte immigration in rat pleurisy induced by carrageenan, and reduction of granuloma weights in the model of subcutaneous granulomas promoted by cotton pellets. In addition, the plant extract significantly inhibited the vascular permeability increase induced by intraperitoneal acetic acid. It also showed marked antinociceptive effect in acetic acid-induced writhing test and in the second phase of formalin test in mice. These findings evidence the anti-inflammatory potential of Bowdichia virgilioides bark and supports its traditional use in inflammatory conditions.
authors.affiliation: Departamento de Ciências Básicas em Saúde, FCM, Universidade Federal de Mato Grosso, Boa Esperança, Campus Universitário, Cuiabá, MT, Brazil.
authors.forename: Wander M
authors.initials: WM
authors.lastname: Barros
authors.forename: Vietla S N
authors.initials: VS
authors.lastname: Rao
authors.forename: Regilane M
authors.initials: RM
authors.lastname: Silva
authors.forename: Joaquim C S
authors.initials: JC
authors.lastname: Lima
authors.forename: Domingos T O
authors.initials: DT
authors.lastname: Martins
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D007887:Fabaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan