title: Randomized controlled trial on lateral augmentation using two collagen membranes: morphometric results on mineralized tissue compound.
abstract: BACKGROUND
  Guided bone regeneration is considered an effective tool for gaining mineralized tissue either at exposed implant surface or in deficient alveolar ridge areas before implant placement.
  
  
  METHODS
  Customized casts obtained following impression taking at surgery and re-entry allowed for morphometric assessment of alveolar ridge alterations 6 months after one-stage augmentation of bone dehiscences. In a randomized pilot study using biphasic calcium phosphate tests (n=17) received treatment with ribose cross-linked collagen membranes (RCLM), whereas controls (n=20) received non-cross-linked membranes. The primary endpoint was to quantify the effect of membrane type on dimensional changes in bone margins at crestal level of endosseous implants.
  
  
  RESULTS
  Soft tissue dehiscencies occurred at 70.5% and 55% frequency for tests and controls, respectively. Gain in clinically hard newly mineralized tissue at the crestal level was significantly higher in test group in lateral (1.8 versus 0.7 mm; p=.046) and in vertical dimensions (1.1 versus 0.2 mm; p=.035) compared with controls. Second measurement obtained at the border of reflected flap revealed no significant difference between groups (3.0 versus 2.1 mm; p=0.57) for lateral dimension.
  
  
  CONCLUSIONS
  Both collagen devices were effective in bone augmentation. RCLMs supported mineralization process and remodelling even in sites showing compromised healing as indicated by morphometric outcome.
authors.affiliation: Department of Periodontology, School of Dentistry, Faculty of Health, University of Witten, Witten, Germany. anton.friedmann@uni-wh.de
authors.forename: Anton
authors.initials: A
authors.lastname: Friedmann
authors.forename: Kirsten
authors.initials: K
authors.lastname: Gissel
authors.forename: Mouaz
authors.initials: M
authors.lastname: Soudan
authors.forename: Bernd-Michael
authors.initials: BM
authors.lastname: Kleber
authors.forename: Sandu
authors.initials: S
authors.lastname: Pitaru
authors.forename: Thomas
authors.initials: T
authors.lastname: Dietrich
mesh_terms: D000328:Adult; D000368:Aged; D000539:Alveolar Process / Q000473:pathology; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001672:Biocompatible Materials / Q000737:chemistry; D016723:Bone Remodeling / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002113:Calcification, Physiologic / Q000502:physiology; D002508:Cephalometry; D003094:Collagen / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006882:Hydroxyapatites / Q000627:therapeutic use; D007576:Jaw, Edentulous, Partially / Q000534:rehabilitation / Q000601:surgery; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010865:Pilot Projects; D012266:Ribose / Q000737:chemistry; D016037:Single-Blind Method; D013529:Surgical Wound Dehiscence / Q000209:etiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C106416:Bio-Gide; D001672:Biocompatible Materials; D018786:Bone Substitutes; C558777:BoneCeramic; D003432:Cross-Linking Reagents; D015921:Dental Implants; D006882:Hydroxyapatites; D008567:Membranes, Artificial; C551508:Ossix; D012266:Ribose; D003094:Collagen