title: Natural history of lamellar macular holes in highly myopic eyes.
abstract: OBJECTIVE
  To determine the natural course of lamellar macular holes (MHs) in highly myopic eyes.
  
  
  METHODS
  Prospective and observational case series.
  
  
  METHODS
  Twenty-four eyes of 21 consecutive patients with a lamellar MH and high myopia (myopic refractive error >8 diopters or axial length ≥26.5 mm) were followed for ≥12 months. The changes of the optical coherence tomography (OCT) findings and the best-corrected visual acuity (BCVA) were analyzed. The progression of the lamellar MH to a full-thickness MH and the change of the BCVA were analyzed.
  
  
  RESULTS
  At the initial examination, an epiretinal membrane was identified by OCT in 17 of the 24 eyes (70.8%) and 7 eyes (29.2%) had macular retinoschisis. Twenty-three of 24 eyes (95.8%) did not show any changes of the lamellar MH in the OCT images during a mean follow-up of 19.2 ± 10.2 months. However, the remaining eye progressed to a full-thickness MH and pars plana vitrectomy was required to close the MH. Except for this 1 eye, the BCVA was maintained (within 0.2 logMAR change) during the follow-up period of at least 1 year.
  
  
  CONCLUSIONS
  A lamellar MH in highly myopic eyes is a relatively stable condition.
authors.affiliation: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Noriaki
authors.initials: N
authors.lastname: Shimada
authors.forename: Muka
authors.initials: M
authors.lastname: Moriyama
authors.forename: Kengo
authors.initials: K
authors.lastname: Hayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Takashi
authors.initials: T
authors.lastname: Tokoro
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ohno-Matsui
mesh_terms: D000328:Adult; D000368:Aged; D019773:Epiretinal Membrane / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000175:diagnosis / Q000503:physiopathology*; D011446:Prospective Studies; D012167:Retinal Perforations / Q000175:diagnosis / Q000503:physiopathology*; D041441:Retinoschisis / Q000175:diagnosis; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology