title: [Abrikosoff's tumor: a clinicopathologic study of nine cases].
abstract: BACKGROUND
  Abrikossoff's tumour or granular cell tumor or is a benign neurogenic tumour. It is ubiquitous with the most frequently affected site is the head and neck region.
  
  
  OBJECTIVE
  To report a series of granular cell tumors and to discuss its clinicopathologic features and histogenesis.
  
  
  METHODS
  We report a series of nine cases diagnosed between January 2004 and December 2006 in the Pathology Department of the University Hospital of Sfax. We have collected the clinical aspects and we have proceeded on a pathological, cytochemical (PAS and PAS diastasis) and immunohistochemical study.
  
  
  RESULTS
  Nine cases of TCG are presented: 5 females and 4 males. The median age was 33.9 years (extremes: 7 and 53 years). All tumours were unique. The most common localization was in the head and neck region (5 cases). The diagnosis was suspected using standard histologic criteria and confirmed by immunohistochemistry: tumour cells expressed vimentine (90%), S100 protein (100%) and neuron specifique enolase (80%). In all cases patients were treated by excisional resection and had a benign course with no evidence of recurrence (median follow up: 2 years).
  
  
  CONCLUSIONS
  Granular cell tumours are rare neoplasm which must be recognised because they demonstrate a benign behaviour after their surgical excision. Histological features of granular cell tumours are commonly characteristic but some times they can be misdiagnosed as malignant tumours especially when the biopsy is superficial. The staining for neurogen markers and PAS are useful tools.
authors.affiliation: CHU Habib Bourguiba, Sfax, Tunisie.
authors.forename: Lobna
authors.initials: L
authors.lastname: Ayadi
authors.forename: Ines
authors.initials: I
authors.lastname: Samet Fakhfakh
authors.forename: Abdelmajid
authors.initials: A
authors.lastname: Khabir
authors.forename: Slim
authors.initials: S
authors.lastname: Charfi
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Bahri
authors.forename: Ahmed
authors.initials: A
authors.lastname: Sellami
authors.forename: Mohamed Hedi
authors.initials: MH
authors.lastname: Abdelmoula
authors.forename: Saloua
authors.initials: S
authors.lastname: Makni
authors.forename: Tahya
authors.initials: T
authors.lastname: Sellami-Boudawara
mesh_terms: D000328:Adult; D049109:Cell Proliferation; D002648:Child; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D047368:Tumor Burden; D055815:Young Adult