title: [Antimicrobial susceptibility and serotype distribution in perinatal group B Streptococcus isolates--a 1999-2009 multicenter study].
abstract: We determined temporary changes in group B Streptococcus antimicrobial susceptibility and serotype distribution from perinatal strains. We examined invasive microbiological isolates from neonates with early-onset group B streptococcal disease (n = 14), and colonized isolates from those born uneventfully (n = 55) and from the genital tracts of pregnant and puerperal women (n = 198), collected between 1999 and 2009. All isolates were susceptible to penicillin. No significant differences were seen in susceptibility of 12 antimicrobial agents examined between invasive and colonized isolates. MIC50, MIC90, and resistance did not differ between stage I (1999-2005) and II (2006-2009) isolates. Serotype distribution significantly differed, however, serotypes III and Ia predominated among invasive isolates, while serotypes Ib and VI were common among their colonized counterparts. These findings suggest that to date, penicillin remains effective in intrapartum prophylactic use in colonized pregnant women.
authors.affiliation: Nagoya City University School of Nursing.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Wakimoto
authors.forename: Yukio
authors.initials: Y
authors.lastname: Wakimoto
authors.forename: Hisako
authors.initials: H
authors.lastname: Yano
authors.forename: Kousaku
authors.initials: K
authors.lastname: Matsubara
authors.forename: Souhei
authors.initials: S
authors.lastname: Miyakawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshida
authors.forename: Katsuko
authors.initials: K
authors.lastname: Okuzumi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sato
authors.forename: Kyoko
authors.initials: K
authors.lastname: Sawada
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Yamada
authors.forename: Masahide
authors.initials: M
authors.lastname: Futamura
authors.forename: Mariko
authors.initials: M
authors.lastname: Kitagawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sato
authors.forename: Masaaki
authors.initials: M
authors.lastname: Minami
authors.forename: Tadao
authors.initials: T
authors.lastname: Hasegawa
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D011247:Pregnancy; D012703:Serotyping; D013292:Streptococcus agalactiae / Q000145:classification* / Q000187:drug effects*
chemical_list: D010406:Penicillins