title: TSH suppression as a possible means of protection against hypothyroidism after irradiation for childhood Hodgkins lymphoma.
abstract: Hypothyroidism remains a common late effect after irradiation of the neck/mediastinum for Hodgkins lymphoma (HL). We evaluated the protective effect of TSH suppression during neck/mediastinum irradiation. From 1998 to 2001, 14 consecutive euthyroid children were given, before and until the end of their radiotherapy on neck/mediastinum, L-thyroxine at TSH-suppressive doses. The 14 patients had adequate TSH suppression during irradiation in 8, inadequate in 6. The 8-year hypothyroidism-free-survival after irradiation was 75 ± 15% for the former group, 0% for the latter (P = 0.009). TSH suppression could have a protective effect on thyroid function as shown in a small group of patients with HL.
authors.affiliation: Pediatrics Unit, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy. maura.massimino@istitutotumori.mi.it
authors.forename: Maura
authors.initials: M
authors.lastname: Massimino
authors.forename: Lorenza
authors.initials: L
authors.lastname: Gandola
authors.forename: Emanuele
authors.initials: E
authors.lastname: Pignoli
authors.forename: Ettore
authors.initials: E
authors.lastname: Seregni
authors.forename: Alfonso
authors.initials: A
authors.lastname: Marchianò
authors.forename: Emilia
authors.initials: E
authors.lastname: Pecori
authors.forename: Serena
authors.initials: S
authors.lastname: Catania
authors.forename: Graziella
authors.initials: G
authors.lastname: Cefalo
mesh_terms: D000293:Adolescent; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D012189:Retrospective Studies; D015996:Survival Rate; D013972:Thyrotropin / Q000037:antagonists & inhibitors* / Q000097:blood; D013974:Thyroxine / Q000008:administration & dosage*
chemical_list: D013972:Thyrotropin; D013974:Thyroxine