title: SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer.
abstract: We performed this study in order to evaluate the impact of the chemokine CXCL12 and its single-nucleotide polymorphism (SNP) rs1801157 on clinicopathological parameters and survival in patients undergoing surgery for esophagogastric cancer. The expression pattern of CXCL12 and its polymorphisms were analyzed by RT-PCR and PCR-RFLP in 69 consecutive fresh-frozen samples of human esophagogastric junction and gastric adenocarcinomas and statistically analyzed. Expression of the CXCL12 (SNP rs1801157) polymorphisms GA/AA significantly correlated with distant metastasis (P=0.026), but not with prognosis. However, CXCL12 expression was not significantly associated with the tumor infiltration depth, lymphatic metastasis and grading. As CXCL12 polymorphisms mediate tumor cell dissemination in esophagogastric cancer, they could represent a marker indicating advanced disease. Antagonists targeting the CXCL12/ CXCR4 axis may be a novel therapeutic option in this entity.
authors.affiliation: Interdisciplinary Translational Oncologic Laboratory , Langenbeckstr. 1, 55131 Mainz, Germany. schimanski@1-med.klinik.uni-mainz.de
authors.forename: Carl C
authors.initials: CC
authors.lastname: Schimanski
authors.forename: Mareike
authors.initials: M
authors.lastname: Jordan
authors.forename: Friederike
authors.initials: F
authors.lastname: Schlaegel
authors.forename: Irene
authors.initials: I
authors.lastname: Schmidtmann
authors.forename: Hauke
authors.initials: H
authors.lastname: Lang
authors.forename: Peter R
authors.initials: PR
authors.lastname: Galle
authors.forename: Markus
authors.initials: M
authors.lastname: Moehler
authors.forename: Ines
authors.initials: I
authors.lastname: Gockel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054377:Chemokine CXCL12 / Q000235:genetics / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology*; D016019:Survival Analysis
chemical_list: D054377:Chemokine CXCL12