title: Biocompatibility of chronically implanted transverse intrafascicular multichannel electrode (TIME) in the rat sciatic nerve.
abstract: The transverse intrafascicular multichannel electrode (TIME) is intended to be transversally implanted in the peripheral nerve and to selectively interface subsets of axons in different fascicles within the same nerve. Two versions of TIME (TIME-2, TIME-3) were designed and tested for biocompatibility and safety in the sciatic nerve of the rat. TIME-2 was implanted in two groups: one group had only an acute implant and the second group had chronic implantation for 2 months; a third group was also chronically implanted with the TIME-3 version, designed to avoid the mechanical traction produced by muscles motion. We evaluated the functional and morphological effects of either TIME-2 or TIME-3 implanted in the rat sciatic nerve for 2 months. The results of the study indicate that implantation of the TIME-2 and TIME-3 devices in the rat sciatic nerve did not cause significant axonal loss or demyelination, as evidenced by the functional and histological results. The results of this study indicate that the TIME-2 and TIME-3 designs are biocompatible and safe after chronic implantation in a small peripheral nerve, such as the rat sciatic nerve.
authors.forename: Jordi
authors.initials: J
authors.lastname: Badia
authors.forename: Tim
authors.initials: T
authors.lastname: Boretius
authors.forename: Arán
authors.initials: A
authors.lastname: Pascual-Font
authors.forename: Esther
authors.initials: E
authors.lastname: Udina
authors.forename: Thomas
authors.initials: T
authors.lastname: Stieglitz
authors.forename: Xavier
authors.initials: X
authors.lastname: Navarro
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D004553:Electric Conductivity; D004567:Electrodes, Implanted; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008422:Materials Testing; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials