title: S-100 protein-positive dendritic cells detected in hepatocellular-carcinoma in relation to tumor progression and prognosis.
abstract: The presence of S-100 protein positive dendritic cells (S-100(+)DC) in primary hepatocellular carcinoma (HCC) were immunohistochemically investigated in relation to clinicopathological factors. The patients who showed a marked infiltration of S-100(+)DC survived longer especially in the group of non-curative resection (P<0.05). In addition, the density numbers of S-100(+)DC related well with the rate of growth of each tumor nodule calculated by ultrasonography (r=0.575, P<0.01). These results indicate that, S-100(+) DC, acting as antigen presenting cells, may play an important role in the host's immune reaction against HCC and are a useful marker for tumor growth and prognosis in HCC.
authors.forename: E
authors.initials: E
authors.lastname: Ido
authors.forename: M
authors.initials: M
authors.lastname: Furihata
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuki
authors.forename: J
authors.initials: J
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Sonobe