title: [Heterogeneity of chronic esophagitis in childhood].
abstract: Chronic esophagitis in children etiologically are heterogeneous. Was observed 83 patients aged from 3 to 17 years with histologically defined chronic esophagitis, 58 of them suffered from food and respiratory allergies. All children underwented endoscopy, morphological and immunohistochemical study of the esophagus biopsies with the definition IgE, IgA herpes simplex virus (HSV), cytomegalovirus (CMV) and Epstein - Barr virus (EBV) in the mucous membrane. The presence of chronic infection was established in 77 out of 83 (92.8%) children. All the patients underwented daily pH meters. GERD was diagnosed in 33 children. GERD was characterized by typical symptoms, combined with gastroduodenal pathology, usually Hp-associated, and increased gastric secretion. Morphologically at 15% of the patients with gastric metaplasia was found moderate inflammation. During examination of patients with allergic esophagitis was neither clinical nor explicit endoscopic manifestations, eosinophilic infiltration was observed in some patients, but inflammatory activity was lower than at GERD and infections. Esophagitis in chronic viral infections was characterized by a higher frequency of erosive changes, higher activity of inflammation. The combination of the three etiological factors were associated with more severe lesions of the esophagus.
authors.forename: E A
authors.initials: EA
authors.lastname: Kornienko
authors.forename: E A
authors.initials: EA
authors.lastname: Filiushkina
authors.forename: R A
authors.initials: RA
authors.lastname: Nasyrov
authors.forename: P V
authors.initials: PV
authors.lastname: Antonov
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D016145:Endoscopy, Digestive System / Q000379:methods; D004941:Esophagitis / Q000175:diagnosis* / Q000473:pathology* / Q000821:virology; D004947:Esophagus / Q000473:pathology / Q000821:virology; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000473:pathology* / Q000821:virology; D006564:Herpesviridae; D006566:Herpesviridae Infections / Q000175:diagnosis* / Q000473:pathology* / Q000821:virology; D006801:Humans; D008297:Male