title: Sterile abscess formation associated with depot leuprorelin acetate therapy for central precocious puberty.
abstract: We describe a case of an 8 year old girl with central precocious puberty. She was commenced on 3 monthly intramuscular depot Leuprorelin acetate therapy, as a result of which she developed sterile abscesses. She was converted to daily subcutaneous Leuprorelin acetate therapy with no recurrence of the abscesses. The possible mechanisms for this reaction are described in the article.
authors.affiliation: Department of Endocrinology, Princess Margaret Hospital for Children, Subiaco, Western Australia, Australia. stephanie.johnson@health.wa.gov.au
authors.forename: Stephanie R
authors.initials: SR
authors.lastname: Johnson
authors.forename: Richard C
authors.initials: RC
authors.lastname: Nolan
authors.forename: Maree T
authors.initials: MT
authors.lastname: Grant
authors.forename: Glynis J
authors.initials: GJ
authors.lastname: Price
authors.forename: Aris
authors.initials: A
authors.lastname: Siafarikas
authors.forename: Lewis
authors.initials: L
authors.lastname: Bint
authors.forename: Catherine Sy
authors.initials: CS
authors.lastname: Choong
mesh_terms: D000038:Abscess / Q000139:chemically induced*; D002648:Child; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007271:Injections, Intradermal / Q000009:adverse effects; D016729:Leuprolide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011629:Puberty, Precocious / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D003692:Delayed-Action Preparations; D016729:Leuprolide