title: Undulation instability of epithelial tissues.
abstract: Treating the epithelium as an incompressible fluid adjacent to a viscoelastic stroma, we find a novel hydrodynamic instability that leads to the formation of protrusions of the epithelium into the stroma. This instability is a candidate for epithelial fingering observed in vivo. It occurs for sufficiently large viscosity, cell-division rate and thickness of the dividing region in the epithelium. Our work provides physical insight into a potential mechanism by which interfaces between epithelia and stromas undulate and potentially by which tissue dysplasia leads to cancerous invasion.
authors.affiliation: Institut Curie, Centre de Recherche, UMR 168, 26 rue d'Ulm, F-75005, Paris, France.
authors.forename: Markus
authors.initials: M
authors.lastname: Basan
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Joanny
authors.forename: Jacques
authors.initials: J
authors.lastname: Prost
authors.forename: Thomas
authors.initials: T
authors.lastname: Risler
mesh_terms: D002455:Cell Division / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology* / Q000502:physiology*; D057446:Hydrodynamics; D008954:Models, Biological; D017154:Stromal Cells / Q000166:cytology* / Q000502:physiology*; D014783:Viscosity