title: [Diagnostic value of serum angiopoietin-2 level in pancreatic cancer].
abstract: OBJECTIVE
  To evaluate the diagnostic value of serum angiopoietin-2 (Ang-2) level in pancreatic cancer patients.
  
  
  METHODS
  Serum Ang-2 level was measured by enzyme-linked immunosorbent assays (ELISA) in samples from 116 patients with pancreatic cancer, 50 patients with chronic pancreatitis, and 50 normal control subjects.
  
  
  RESULTS
  The serum Ang-2 level in patients with pancreatic cancer [(1539.0 ± 449.3) ng/L] was significantly higher than those in patients with pancreatitis [(1044.6 ± 246.1) ng/L, P < 0.01] and normal control subjects [(1075.6 ± 228.2) ng/L, P < 0.01]. There was no significant difference of serum Ang-2 levels between patients with pancreatitis and normal controls. Pancreatic caner patients with lymph node metastasis had a significantly higher serum Ang-2 level [(1890.1 ± 354.9) ng/L] than those without metastasis [(1212.1 ± 224.2) ng/L, P < 0.01]. The area under ROC curve of serum Ang-2 level for diagnosis of pancreatic cancer was 0.819.
  
  
  CONCLUSIONS
  The serum Ang-2 level can be a useful indicator for diagnosis of pancreatic cancer.
authors.affiliation: Department of Clinical Laboratory, Dongyang Affiliated Hospital of Wenzhou Medical College (Dongyang People's Hospital), Dongyang, Zhejiang 322100, China. dyyyjnkwrg@163.com
authors.forename: Ru-Gen
authors.initials: RG
authors.lastname: Wan
authors.forename: De-Bao
authors.initials: DB
authors.lastname: Chen
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Lou
authors.forename: Mao-Feng
authors.initials: MF
authors.lastname: Wang
authors.forename: Qiao-Hong
authors.initials: QH
authors.lastname: Zhang
authors.forename: Dan-Xia
authors.initials: DX
authors.lastname: Jin
authors.forename: Sun-Hong
authors.initials: SH
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D042702:Angiopoietin-2 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D010195:Pancreatitis / Q000097:blood; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D042702:Angiopoietin-2