title: Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory.
abstract: Long-term memory formation involves covalent modification of the histone proteins that package DNA. Reducing histone acetylation by mutating histone acetyltransferases impairs long-term memory, and enhancing histone acetylation by inhibiting histone deacetylases (HDACs) improves long-term memory. Previous studies using HDAC inhibitors to enhance long-term memory have focused on the fear-conditioning task using broad-spectrum HDAC inhibitors. We have found that post-training intrahippocampal administration of the broad-spectrum HDAC inhibitor trichostatin A (TSA) or the class I HDAC-selective inhibitor MS275 enhances long-term object-location memory, supporting a role for class I HDACs in the enhancement of hippocampus-dependent memory induced by HDAC inhibition.
authors.affiliation: Neuroscience Graduate Group, Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Hawk
authors.forename: Cédrick
authors.initials: C
authors.lastname: Florian
authors.forename: Ted
authors.initials: T
authors.lastname: Abel
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001549:Benzamides / Q000494:pharmacology; D003463:Cues; D005106:Exploratory Behavior / Q000187:drug effects*; D058785:GABA-A Receptor Agonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology*; D056284:Histone Deacetylase 1 / Q000378:metabolism*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009118:Muscimol / Q000494:pharmacology; D010775:Photic Stimulation / Q000379:methods; D011725:Pyridines / Q000494:pharmacology; D013997:Time Factors
chemical_list: D001549:Benzamides; D058785:GABA-A Receptor Agonists; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D011725:Pyridines; C118739:entinostat; D009118:Muscimol; C012589:trichostatin A; D056284:Histone Deacetylase 1