title: [The study of CD4+ and CD8+ T subsets in chronic hepatitis B patients].
abstract: OBJECTIVE
  To investigate the difference of CD4+ and CD8+ T subsets in different infection status of chronic hepatitis B (CHB) patients.
  
  
  METHODS
  13 Healthy people were chosen as control group. According to infection status, 78 CHB patients were sorted into HBeAg(+) and normal liver function group, HBeAg(+) and abnormal liver function group, and HBeAg(-) group. The percentages of some subsets of CD4+T and CD8+T cells in CHB patients and healthy people were examined by Flow cytometer, and the correlations between the subsets of T cells and the HBVDNA levels and HBeAg were analyzed.
  
  
  RESULTS
  As compared with control group, the percentages of CD4+CD25+/CD4+ and CD4+CD95+/CD4+ were increased (P<0.01, P<0.05) in HBeAg(+) and normal liver function group, and the percentages of CD8+CD28-/CD8+ in three patients groups were increased (P<0.01). As compared with the HBeAg(+) and normal liver function group, the percentages of CD4+CD25+/CD4+ in HBeAg(+) and abnormal liver function group, and HBeAg(-) group were decreased (P<0.01), and the percentages of CD8+CD95+/CD8+ in HBeAg(-) group and the percentages of CD8+CD95+/CD8 in HBeAg(+) and abnormal liver function group were decreased (P<0.05, P<0.01). Moreover, there were positive correlations between CD4+CD25+/CD4+, CD4+CD95+/CD4+ and the HBVDNA levels(P<0.01); there were inverse correlations between CD4+CD28+/CD4+ and the HBVDNA levels and HBeAg (P<0.05, P<0.01); there were positive correlations between CD8+CD28-/CD8+ and HBVDNA and HBeAg (P<0.01).
  
  
  CONCLUSIONS
  Some T cell Subsets, including CD4+CD25+, CD4+CD95+ , and CD8+CD28-, are increased in CHB patients, which maybe play some roles in the immune tolerance of chronic HBV infection.
authors.affiliation: Shuguang Hospital Affliated to Shanghai University of TCM, Cellular Immunity Laboratory of State Administration of TCM of China, Shanghai 200021, China. susan_sxh@sina.com
authors.forename: Xue-hua
authors.initials: XH
authors.lastname: Sun
authors.forename: Qiao-li
authors.initials: QL
authors.lastname: Liu
authors.forename: Man
authors.initials: M
authors.lastname: Li
authors.forename: Yue-qiu
authors.initials: YQ
authors.lastname: Gao
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D019694:Hepatitis B, Chronic / Q000276:immunology*; D006801:Humans; D008297:Male; D016176:T-Lymphocyte Subsets / Q000276:immunology*