title: Understand memory, design better vaccines.
abstract: Naive lymphocytes have a finite lifespan and are continually replaced by input from generative organs. In contrast, memory cells or their progeny can last a lifetime. The expanded populations of memory cells and their more widespread distribution provide protection against recurrent infection.
authors.affiliation: Department of Immunology, University of Washington and Howard Hughes Medical Institute, Seattle, Washington, USA. mbevan@uw.edu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bevan
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D001424:Bacterial Infections / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014612:Vaccines / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology
chemical_list: D016207:Cytokines; D014612:Vaccines