title: Primary central-nervous-system lymphoma - treatment with multiagent systemic and intrathecal chemotherapy with radiation-therapy.
abstract: Nine patients with primary central nervous system lymphoma (PCNSL) were evaluated in a protocol of systemic and intrathecal chemotherapy and radiation therapy (RT). The median survival was 30 months; median time to recurrence was 14 months. Leukoencephalopathy developed in 7/9 patients, 6-12 months after combination therapy. 5/9 patients worsened cognitively 6-14 months after therapy; all developed leukoencephalopathy. The four patients who had an initial positive cytology or delayed CSF outflow did not worsen cognitively, although two developed leukoencephalopathy. The combination of chemotherapy and RT improves survival of patients with PCNSL; however, leukoencephalopathy and cognitive changes are frequent.
authors.affiliation: UNIV MICHIGAN,MED CTR,DEPT NEUROL,1500 E MED CTR DR,1914 TAUBMAN CTR,BOX 0316,ANN ARBOR,MI 48109. UNIV MICHIGAN,MED CTR,DEPT RADIAT ONCOL,ANN ARBOR,MI 48109. UNIV MICHIGAN,MED CTR,DEPT SURG,NEUROSURG SECT,ANN ARBOR,MI 48109. UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,ANN ARBOR,MI 48109. WESTERN GEN HOSP,DEPT CLIN NEUROSCI,NEUROL UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND.
authors.forename: B
authors.initials: B
authors.lastname: Liang
authors.forename: R
authors.initials: R
authors.lastname: Grant
authors.forename: L
authors.initials: L
authors.lastname: Junck
authors.forename: H
authors.initials: H
authors.lastname: Sandler
authors.forename: S
authors.initials: S
authors.lastname: Papadopoulos
authors.forename: M
authors.initials: M
authors.lastname: Kaminski
authors.forename: H
authors.initials: H
authors.lastname: Greenberg