title: [Vacuum-assisted therapy for various wound types including diabetic foot ulcer].
abstract: BACKGROUND
  Vacuum is a noninvasive system that creates a localized controlled negative pressure environment. In this study, vacuum was provided by the V.A.C. Therapy system, which promotes wound healing by delayed primary or secondary intention through creating a moist wound environment, preparing the wound bed for closure, reducing edema, and promoting formation and perfusion of granulation tissue. Vacuum-assisted closure therapy is indicated for use in all care settings and for a variety of wound types including diabetic foot ulcers.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate safety and clinical efficacy of negative pressure wound therapy (NPWT) compared with advanced moist wound therapy and standard treatment to treat foot ulcers in diabetic patients.
  
  
  METHODS
  This trial enrolled 43 patients; most of them were diabetic patients at any age with various skin ulcers and diabetic foot. These patients were divided into two groups, 17 patients were treated with vacuum and the 26 patients in the control group were treated with standard therapy including debridement.
  
  
  RESULTS
  A greater proportion of foot and skin ulcers achieved complete ulcer closure with vacuum-assisted therapy p<0.001 compared with the standard therapy. Vacuum therapy significantly decreased the duration and frequency of admission p=0.032 and decreased the rate of amputation p<0.001.
  
  
  CONCLUSIONS
  Results of our trial support other studies and demonstrate that vacuum is as safe as and more efficacious than standard therapy in the treatment of diabetic foot ulcers. A significantly greater number of patients achieved complete ulcer closure and granulation tissue formation with this therapy. The study group showed a significant reduction in the median time needed to heal ulcers, reduction of the number of admissions and amputation frequency.
authors.affiliation: Internal Medicine Department B, Ziv Medical Center, Safed, Israel affiliated to Technion Faculty of Medicine, Haifa, Israel. Raymond.F@ziv.health.gov.il
authors.forename: Raymond
authors.initials: R
authors.lastname: Farah
authors.forename: Maher
authors.initials: M
authors.lastname: Gantus
authors.forename: Leonid
authors.initials: L
authors.lastname: Kogan
mesh_terms: D000368:Aged; D000671:Amputation, Surgical / Q000706:statistics & numerical data; D003646:Debridement / Q000379:methods; D017719:Diabetic Foot / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D012883:Skin Ulcer / Q000473:pathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing