title: A circulating heat-resistant mucin-like antigen in patients with lung-cancer detected by a new murine monoclonal-antibody.
abstract: We discovered a circulating mucin-like antigen designated as CAM-14 detected by a new murine monoclonal antibody KL-14 (IgM). We found different heat resistant properties between serum CAM- 14 from normal individuals and from lung cancer patients. Heat treatment had less effect on the levels of CAM-14 in sera from lung cancer patients, whereas CAM-14 levels in sera from normal individuals were markedly decreased after heat treatment at tempratures > 65-degrees-C. As a serum tumor marker, CAM- 14 had only very low levels of false-positive values with a high specificity and effectively increased the positive rate for lung cancer patients when used together with carcinoembryonic antigen.
authors.affiliation: KITANO HOSP,TAZUKE KOFUKAI MED RES INST,DEPT THORAC SURG,KITAKU,OSAKA 530,JAPAN. RADIAT EFFECTS RES FDN,DEPT RADIAT BIOL,MINAMI KU,HIROSHIMA 732,JAPAN. HIROSHIMA UNIV,SCH MED,DEPT INTERNAL MED 2,MINAMI KU,HIROSHIMA 734,JAPAN.
authors.forename: N
authors.initials: N
authors.lastname: Kohno
authors.forename: M
authors.initials: M
authors.lastname: Miyake
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: A
authors.initials: A
authors.lastname: Yokoyama
authors.forename: K
authors.initials: K
authors.lastname: Hiwada
authors.forename: M
authors.initials: M
authors.lastname: Tanabe
authors.forename: M
authors.initials: M
authors.lastname: Yamakido
authors.forename: S
authors.initials: S
authors.lastname: Kyoizumi
authors.forename: M
authors.initials: M
authors.lastname: Akiyama