title: Mean platelet volume as a fibrosis marker in patients with chronic hepatitis B.
abstract: BACKGROUND
  Many noninvasive tests have been studied for the diagnosis and determining the liver fibrosis score (LFS). In this study, we aimed to research the correlation of mean platelet volume (MPV) and stage of liver fibrosis in patients with chronic hepatitis B (CHB).
  
  
  METHODS
  Fifty-nine patients with CHB were enrolled retrospectively into the study. Age-sex matched 25 healthy subjects were used as control group. The following data were obtained from computerized patient registry database: HBV-DNA level, hepatitis B e-antigen seropositivity, liver enzymes and function tests, white blood cell count, platelet count, hemoglobin, histological activity index, LFS, and MPV. Patients were divided into two groups: patients without significant fibrosis (F0, F1, or F2) (Group 1) and patients with advanced fibrosis (F3, F4) (Group 2).
  
  
  RESULTS
  A statistically significant increase in MPV was seen in patients with CHB compared with healthy controls (8.49±0.84 fl vs.7.65±0.42 fl, P<0.001). Receiver operating characteristic curve analysis suggested that the optimum MPV level cut-off points for CHB was 8.0 fl, with sensitivity, specificity, PPV, and NPV of 68, 76, 86, and 50%, respectively. MPV levels were significantly higher in Group 2 (8.91±0.94 fl, P: 0.009) compared with Group 1 (8.32±0.74 fl). ROC curve analysis suggested that the optimum MPV level cut-off points for Group 2 was 8.45 fl, with sensitivity, specificity, positive and negative predictive value of 77, 59, 45, and 85%, respectively. Multivariable logistic regression model, which consisted of HAI, ALT, HBV-DNA, platelet count, and MPV, was performed. We showed that MPV was independently associated with advanced fibrosis (P: 0.031).
  
  
  CONCLUSIONS
  We suggest that MPV might help in the assessment of fibrosis in CHB. It should not be considered a stand-alone test for this use owing to nonspecificity with other diseases.
authors.affiliation: Dışkapı Yıldırım Beyazıt Educational and Research Hospital, Department of Gastroenterology, Ankara, Turkey. dr_ekiz@yahoo.com
authors.forename: Fuat
authors.initials: F
authors.lastname: Ekiz
authors.forename: Osman
authors.initials: O
authors.lastname: Yüksel
authors.forename: Erdem
authors.initials: E
authors.lastname: Koçak
authors.forename: Barış
authors.initials: B
authors.lastname: Yılmaz
authors.forename: Akif
authors.initials: A
authors.lastname: Altınbaş
authors.forename: Sahin
authors.initials: S
authors.lastname: Çoban
authors.forename: Ilhami
authors.initials: I
authors.lastname: Yüksel
authors.forename: Oğuz
authors.initials: O
authors.lastname: Üsküdar
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Köklü
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003710:Demography; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count
chemical_list: D015415:Biomarkers