title: Carbonylation of styrenes catalyzed by bioxazoline Pd(II) complexes: mechanism of enantioselectivity.
abstract: Preliminary studies of the elementary steps involved in the reaction of a chiral methyl carbonyl bioxazoline Pd(II) complex with aromatic olefins and CO have allowed development of a new enantioselective catalytic carbonylation process, leading to γ-ketoester derivatives with high yield and good enantiomeric excess. The intermediate palladacycle complexes have been isolated and characterized by NMR spectroscopy and X-ray diffraction. Factors that govern the stereoselectivity of the olefin carbonylation process are discussed.
authors.affiliation: Dipartimento di Scienze Biomolecolari, Università di Urbino, Piazza Rinascimento, 6-61029, Urbino, Italy. carla.carfagna@uniurb.it
authors.forename: Carla
authors.initials: C
authors.lastname: Carfagna
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gatti
authors.forename: Luca
authors.initials: L
authors.lastname: Mosca
authors.forename: Paolo
authors.initials: P
authors.lastname: Natanti
authors.forename: Paola
authors.initials: P
authors.lastname: Paoli
authors.forename: Patrizia
authors.initials: P
authors.lastname: Rossi
authors.forename: Bartolo
authors.initials: B
authors.lastname: Gabriele
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Salerno
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002248:Carbon Monoxide / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013343:Styrenes / Q000737:chemistry*
chemical_list: D000475:Alkenes; D056831:Coordination Complexes; D013343:Styrenes; D010165:Palladium; D002248:Carbon Monoxide