title: Nuclear organization and transcriptional dynamics in Dictyostelium.
abstract: The Dictyostelium model has a set of features uniquely well-suited to developing our understanding of transcriptional control. The complete Dictyostelium discoideum genome sequence has revealed that many of the molecular components regulating transcription in larger eukaryotes are conserved in Dictyostelium, from transcription factors and chromatin components to the enzymes and signals that regulate them. In addition, the system permits visualization of single gene firing events in living cells, which provides a more detailed view of transcription and its relationships to cell and developmental processes. This review will bring together the available knowledge of the structure and dynamics of the Dictyostelium nucleus and discuss recent transcription imaging studies and their implications for stability and accuracy of cell decisions.
authors.affiliation: Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Stevense
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Chubb
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Muramoto
mesh_terms: D000595:Amino Acid Sequence; D002467:Cell Nucleus / Q000378:metabolism*; D004023:Dictyostelium / Q000235:genetics*; D006657:Histones / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic
chemical_list: D006657:Histones