title: Prognostic value of oncoproteins for the survival of patients with nonsmall cell lung carcinomas.
abstract: Patients with non-small cell lung carcinomas whose tumors showed an overexpression of the oncogenes c-fos and c-N-ras at the protein level had significantly shorter survival times than those without overexpression of these oncogene products. (c-fos: p=0.0002, c-N-ras: p=0.002). Multivariate analysis showed that expression of proteins coded by c-fos and c-N-ras is a significant prognostic factor in addition to tumor staging and DNA ploidy. The prognostic value is improved by combining the expression of c-fos and c-N-ras products. A significant correlation between the expression of c-fos and c-N-ras products and the tumor take rate in nude mice was found.
authors.affiliation: THORAX CLIN HEIDELBERG ROHRBACH,W-6900 HEIDELBERG,GERMANY.
authors.forename: M
authors.initials: M
authors.lastname: Volm
authors.forename: P
authors.initials: P
authors.lastname: Drings
authors.forename: J
authors.initials: J
authors.lastname: Mattern
authors.forename: W
authors.initials: W
authors.lastname: Wodrich