title: Adjuvant docetaxel/cyclophosphamide in breast cancer patients over the age of 70: results of an observational study.
abstract: This retrospective observational study was designed to describe feasibility and tolerance of adjuvant Taxotere®/cyclophosphamide (TC) chemotherapy in women aged over 70 years with early breast cancer. Data including geriatric evaluations were collected from the medical charts of 110 patients from 14 oncology institutions in France who had completed adjuvant systemic TC (91% received at least 4 cycles). Median age was 73 years (range 70-85), 51% of patients had breast conserving surgery, 42% had a tumor smaller than 2cm and 33% had positive nodes. Geriatric assessment was performed by oncologists in 88% of patients; 55% were considered fit, 5% had geriatric syndrome and 10% had more than three comorbidities. Neutropenia was reported in 15% of patients, including febrile neutropenia and/or grade 4 in 5% for each. Primary prophylactic G-CSF was given to 49% of patients. In a selected population of elderly patients, 4 cycles of adjuvant TC is feasible without major toxicity, confirming the US Oncology trial data.
authors.affiliation: Department of Medical Oncology, Centre Hospitalier Lyon-Sud and Université de Lyon, France. gilles.freyer@chu-lyon.fr
authors.forename: Gilles
authors.initials: G
authors.lastname: Freyer
authors.forename: Mario
authors.initials: M
authors.lastname: Campone
authors.forename: Julien
authors.initials: J
authors.lastname: Peron
authors.forename: Thomas
authors.initials: T
authors.lastname: Facchini
authors.forename: Catherine
authors.initials: C
authors.lastname: Terret
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Berdah
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Jacquin
authors.forename: David
authors.initials: D
authors.lastname: Coeffic
authors.forename: Pierre de Saint
authors.initials: Pde S
authors.lastname: Hilaire
authors.forename: Claire
authors.initials: C
authors.lastname: Falandry
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use*; D000077143:Docetaxel; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D012189:Retrospective Studies; D043823:Taxoids / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D003520:Cyclophosphamide