title: Effect of cardiac rehabilitation on inflammatory markers in patients with high risk for obstructive sleep apnea: a pilot study.
abstract: Our primary objective in this study was to determine the differences in inflammatory profile between patients with high risk for obstructive sleep apnea (OSA) versus low risk in a patient population undergoing cardiac rehabilitation and to evaluate the effect of 4 weeks of rehabilitation on cytokine levels in the 2 groups. A total of 20 consecutive patients were screened using the Berlin questionnaire to determine high and low risk of OSA. Of the 20 total consecutive patients, 3 patients did not consent to participate and 1 did not get cytokine analysis. Of the remaining 16 patients (8 men and 8 women), 8 (50%) patients were found to have high risk for OSA as predicted by the Berlin questionnaire. Men predominated the high-risk group (75%). There was a trend of increased cytokine load in the high-risk group; however, it did not reach statistical significance except for monocyte chemoattractant protein-1 (P value=0.02). A significant reduction was noted in cytokine levels after 4 weeks of rehabilitation in the group with OSA, which was statistically significant (P value<0.5). The high-risk group patients had elevated cytokine levels, especially monocyte chemoattractant protein-1. Further, a significant reduction in cytokine levels was noted in the high-risk group after 4 weeks of rehabilitation.
authors.affiliation: Department Radiology, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Adrian T
authors.initials: AT
authors.lastname: Parker
authors.forename: Sunil
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018932:Chemokine CCL2 / Q000235:genetics / Q000378:metabolism; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000276:immunology / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D011175:Positive-Pressure Respiration; D012306:Risk; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000276:immunology / Q000534:rehabilitation*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D015854:Up-Regulation / Q000276:immunology
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D018836:Inflammation Mediators