title: Vascular consequences of a high-fat meal in physically active and inactive adults.
abstract: Habitually active adults (ACT) typically exhibit lower postprandial lipemia, a condition that may attenuate oxidative stress and endothelial dysfunction following a high-fat meal (HFM), compared with inactive adults (INA). Our objective was to compare triglycerides (TAG), superoxide dismutase activity (SOD), oxidative stress (thiobarbituric reactive substances; TBARS), and brachial artery flow-mediated dilation (FMD%) before and after an HFM challenge in ACT and INA. ACT (n = 7) and INA (n = 7) subjects were matched for body mass index, age, and sex. Plasma TAG, SOD, TBARS, and FMD% were measured at baseline and 4 h after an HFM challenge. TAG significantly increased following the HFM in INA (4.15 ± 3.79 mmol·L(-1) vs. 8.07 ± 5.12 mmol·L(-1)) and in ACT (2.16 ± 0.55 mmol·L(-1) vs. 3.24 ± 1.40 mmol·L(-1)). Baseline TBARS were greater in ACT and remained unchanged in response to the HFM in both INA (5.1 ± 2.7 mmol·L(-1) vs. 6.9 ± 2.9 mmol·L(-1)) and ACT (8.6 ± 2.0 mmol·L(-1) vs. 7.9 ± 1.9 mmol·L(-1)). ACT exhibited greater SOD than INA at baseline (8.6 ± 0.7 U·mL(-1) vs. 7.8 ± 0.6 U·mL(-1)) and following the HFM (9.3 ± 1.2 U·mL(-1) vs. 8.0 ± 0.7 U·mL(-1)). Postprandial FMD% was decreased in INA (9.1% ± 4.0% vs. 6.2% ± 3.4%), yet remained unchanged in ACT (7.9% ± 3.7% vs. 9.3% ± 3.2%). In conclusion, the differential responses following an HFM support the concept that habitual physical activity can attenuate the negative postprandial alterations that affect vascular health.
authors.affiliation: Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA. bj33@indiana.edu
authors.forename: Blair D
authors.initials: BD
authors.lastname: Johnson
authors.forename: Jaume
authors.initials: J
authors.lastname: Padilla
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Harris
authors.forename: Janet P
authors.initials: JP
authors.lastname: Wallace
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D018384:Oxidative Stress / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D008055:Lipids