title: Multicentric hepatic EBV-associated smooth muscle tumors in an AIDS patient: a case report, investigation of mTOR activation and review of the literature.
abstract: Epstein-Barr virus (EBV) - associated smooth muscle tumors (EBV-SMT) are a rare, recently recognized distinct group of mesenchymal tumors that develop exclusively in patients with immunosuppression. It is believed that tumorigenesis is, at least in part, through the activation of the Akt/mammalian target of rapamycin (mTOR) signal pathway. We describe the clinicopathologic and immunohistochemical features of a multifocal hepatic EBV-SMT in a 34-year-old acquired immunodeficiency syndrome (AIDS) patient and investigate the activation status of the mTOR signal pathway in this tumor. In addition, we provide a review of the literature on the clinicopathologic findings of hepatic EBV-SMT in adult AIDS patients, and discuss their biologies and possible therapeutic strategies.
authors.affiliation: Department of Pathology and Laboratory Medicine, the University of Texas Medical School at Houston, Houston TX,USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.forename: Michael S
authors.initials: MS
authors.lastname: Long
authors.forename: Xiuzhen
authors.initials: X
authors.lastname: Duan
authors.forename: Siraya
authors.initials: S
authors.lastname: Jaijakul
authors.forename: Cesar A
authors.initials: CA
authors.lastname: Arias
authors.forename: Robert E
authors.initials: RE
authors.lastname: Brown
authors.forename: Bihong
authors.initials: B
authors.lastname: Zhao
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D015497:HIV-1 / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008113:Liver Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D008297:Male; D012367:RNA, Viral / Q000032:analysis / Q000097:blood / Q000235:genetics; D015398:Signal Transduction; D018235:Smooth Muscle Tumor / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases