title: Mitochondrial division: molecular machinery and physiological functions.
abstract: Mitochondrial division has emerged as a key mechanism for this essential organelle to maintain its structural integrity, intracellular distribution, and functional competence. An evolutionarily conserved dynamin-related GTPase, Dnm1p/Drp1, interacts with other proteins to form the core machinery involved in mitochondrial division. We summarize recent progress in understanding how the division machinery assembles onto mitochondria and how mitochondrial division contributes to cellular physiology and human diseases.
authors.affiliation: Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kageyama
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sesaki
mesh_terms: D000818:Animals; D017209:Apoptosis; D034281:Dynamins / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000201:enzymology / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins; D020558:GTP Phosphohydrolases; D034281:Dynamins