title: Trim5 TAKes on pattern recognition.
abstract: Retroviral capsids can be recognized and degraded by a host protein, Trim5α. A recent study in Nature (Pertel et al., 2011) shows that, upon sensing of the retrovirus capsid lattice, Trim5α generates free ubiquitin chains that activate the TAK1 kinase and downstream innate immune response genes.
authors.affiliation: Immune Design Corp., 1124 Columbia Street, Suite 700, Seattle, WA 98104, USA. semih.tareen@immunedesign.com
authors.forename: Semih U
authors.initials: SU
authors.lastname: Tareen
authors.forename: Michael
authors.initials: M
authors.lastname: Emerman