title: Infant skin-cleansing product versus water: a pilot randomized, assessor-blinded controlled trial.
abstract: BACKGROUND
  The vulnerability of newborn babies' skin creates the potential for a number of skin problems. Despite this, there remains a dearth of good quality evidence to inform practice. Published studies comparing water with a skin-cleansing product have not provided adequate data to inform an adequately powered trial. Nor have they distinguished between babies with and without a predisposition to atopic eczema. We conducted a pilot study as a prequel to designing an optimum trial to investigate whether bathing with a specific cleansing product is superior to bathing with water alone. The aims were to produce baseline data which would inform decisions for the main trial design (i.e. population, primary outcome, sample size calculation) and to optimize the robustness of trial processes within the study setting.
  
  
  METHODS
  100 healthy, full term neonates aged <24 hours were randomly assigned to bathing with water and cotton wool (W) or with a cleaning product (CP). A minimum of bathing 3 times per week was advocated. Groups were stratified according to family history of atopic eczema. Transepidermal water loss (TEWL), stratum corneum hydration and skin surface pH were measured within 24 hours of birth and at 4 and 8 weeks post birth. Measurements were taken on the thigh, forearm and abdomen. Women also completed questionnaires and diaries to record bathing practices and medical treatments.
  
  
  RESULTS
  Forty nine babies were randomized to cleansing product, 51 to water. The 95% confidence intervals (CI) for the average TEWL measurement at each time point were: whole sample at baseline: 10.8 g/m(2)/h to 11.7 g/m(2)/h; CP group 4 weeks: 10.9 g/m(2)/h to 13.3 g/m(2)/h; 8 weeks: 11.4 g/m(2)/h to 12.9 g/m(2)/h; W group 4 weeks:10.9 g/m(2)/h to 12.2 g/m(2)/h; 8 weeks: 11.4 g/m(2)/h to 12.9 g/m(2)/h.
  
  
  CONCLUSIONS
  This pilot study provided valuable baseline data and important information on trial processes. The decision to proceed with a superiority trial, for example, was inconsistent with our data; therefore a non-inferiority trial is recommended.
authors.affiliation: School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK. tina.lavender@manchester.ac.uk
authors.forename: Tina
authors.initials: T
authors.lastname: Lavender
authors.forename: Carol
authors.initials: C
authors.lastname: Bedwell
authors.forename: Ediri
authors.initials: E
authors.lastname: O'Brien
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Cork
authors.forename: Mark
authors.initials: M
authors.lastname: Turner
authors.forename: Anna
authors.initials: A
authors.lastname: Hart
mesh_terms: D001494:Baths / Q000379:methods*; D003902:Detergents; D005260:Female; D006801:Humans; D007223:Infant; D007224:Infant Care / Q000379:methods*; D007231:Infant, Newborn; D008297:Male; D010865:Pilot Projects; D016037:Single-Blind Method; D017592:Skin Care / Q000379:methods*; D014867:Water
chemical_list: D003902:Detergents; D014867:Water