title: Association between vitamin D receptor gene polymorphisms and type 1 diabetes mellitus in Iranian population.
abstract: Type 1 diabetes mellitus (T1DM) is one of the T-cell mediated autoimmune diseases and vitamin D suppresses activation of T-cell and has immunomodulatory effects. In this study the association between four vitamin D receptor (VDR) gene polymorphisms, at positions FokI, BsmI, ApaI and TaqI, and susceptibility to T1DM was investigated. We assessed 87 Iranian patients with T1DM and one hundred healthy controls with no history of diabetes or other autoimmune diseases. Our results demonstrated that genotypes frequency of the TaqI VDR polymorphism differed significantly between T1DM patients and controls, TT genotype and T allele was more frequent in healthy controls compared with TIDM patients (P = 0.003; OR = 0.51, 95% CI = 0.31-0.84). Therefore, allele t is the risk-allele for developing TIDM in this study. No significant association was observed between others VDR SNPs and disease susceptibility. In conclusion, our case-control study indicated that the VDR TaqI polymorphism is associated with TIDM in Iranian population.
authors.affiliation: Immunology Research Center, Buali Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Mohammadnejad
authors.forename: Mohsen
authors.initials: M
authors.lastname: Ghanbari
authors.forename: Rashin
authors.initials: R
authors.lastname: Ganjali
authors.forename: Jalil Tavakkol
authors.initials: JT
authors.lastname: Afshari
authors.forename: Mahyar
authors.initials: M
authors.lastname: Heydarpour
authors.forename: Seyed Morteza
authors.initials: SM
authors.lastname: Taghavi
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Fatemi
authors.forename: Houshang
authors.initials: H
authors.lastname: Rafatpanah
mesh_terms: D017931:DNA Primers / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007492:Iran / Q000453:epidemiology; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors
chemical_list: D017931:DNA Primers; D018167:Receptors, Calcitriol