title: Ras p21 expression in neuroblastomas and ganglio-neuroblastomas - correlation with patients prognosis.
abstract: Ras p21 expression was investigated in 28 cases of neuroblastomas and 12 cases of ganglio-neuroblastomas by the biotin-streptavidin immunoperoxidase method using the anti-ras p21 rat monoclonal antibody Y13-259. The results showed that 28% of neuroblastomas and 92% of ganglio-neuroblastomas demonstrated elevated ras p21 expression. However, in this series of patients 10 of 12 ganglio-neuroblastomas were staged as early disease (stage I or II) compared to 15 of 28 neuroblastomas, with similar staged disease. On analysing all of these tumours into early and late disease (i.e. stage I and II; and stage III and IV) a correlation was found between p21-ras overexpression and early disease (P<0.0001). As staging of neuroblastomas has been considered to be a prognostic indicator, it is argued that ras p21 over-expression maybe an indicator for a favourable prognosis in these patients.
authors.affiliation: UNIV CRETE,SCH MED,IRAKLION,GREECE. AGHIA SOPHIA CHILDRENS HOSP,DEPT PATHOL,ATHENS,GREECE. UNIV LIVERPOOL,DEPT CLIN DENT SCI,LIVERPOOL L69 3BX,ENGLAND.
authors.forename: D
authors.initials: D
authors.lastname: Spandidos
authors.forename: D
authors.initials: D
authors.lastname: Arvanitis
authors.forename: J
authors.initials: J
authors.lastname: Field