title: [Congenital toxoplasmosis: severe ocular and neurological complications].
abstract: Two infants with congenital toxoplasmosis are presented. A girl born prematurely was treated postnatally after the mother had received antimicrobial treatment during pregnancy for acute toxoplasmosis. Apart from being small for gestational age, she remained without symptoms and treatment was ceased after 13 months. A 2-month-old boy presented with hydrocephalus and chorioretinitis, consistent with congenital toxoplasmosis. Despite antimicrobial treatment, at 12 months of age he suffered from epilepsy, cerebral palsy and vision impairment. Most infants with congenital toxoplasmosis (2 per 1000 live births in the Netherlands) are asymptomatic at birth. The education of pregnant women is crucial for the prevention of congenital toxoplasmosis. Awareness of antenatal and postnatal presenting signs and symptoms is important for clinicians, because early diagnosis and treatment may minimize sequelae. Untreated, the majority of affected infants will develop chorioretinitis, deafness and/or neurological symptoms.
authors.affiliation: Canisius-Wilhelmina Ziekenhuis, Afd. Kindergeneeskunde, Nijmegen, the Netherlands.
authors.forename: Franka
authors.initials: F
authors.lastname: Hoekstra
authors.forename: Cecile
authors.initials: C
authors.lastname: Buzing
authors.forename: Jan M J
authors.initials: JM
authors.lastname: Sporken
authors.forename: Corry E
authors.initials: CE
authors.lastname: Erasmus
authors.forename: Michiel
authors.initials: M
authors.lastname: van der Flier
authors.forename: Ben A
authors.initials: BA
authors.lastname: Semmekrot
mesh_terms: D002825:Chorioretinitis / Q000151:congenital / Q000209:etiology; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000151:congenital / Q000209:etiology; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D015997:Neonatal Screening; D011247:Pregnancy; D016781:Toxoplasmosis, Cerebral / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control; D014125:Toxoplasmosis, Congenital / Q000150:complications* / Q000175:diagnosis* / Q000517:prevention & control; D014126:Toxoplasmosis, Ocular / Q000150:complications* / Q000151:congenital / Q000175:diagnosis / Q000517:prevention & control