title: Somatostatin receptors as targets for nuclear medicine imaging and radionuclide treatment.
abstract: Radiolabeled peptides have been an important class of compounds in radiopharmaceutical sciences and nuclear medicine for more than 20 years. Despite strong research efforts, only somatostatin-based radiopeptides have a real impact on patient care, diagnostically and therapeutically. [(111)In-diethylenetriaminepentaacetic acid(0)]octreotide is commercially available for imaging. Imaging was highly improved by the introduction of PET radionuclides such as (68)Ga, (64)Cu, and (18)F. Two peptides are successfully used in targeted radionuclide therapy when bound to DOTA and labeled with (90)Y and (177)Lu.
authors.affiliation: Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany. helmut.maecke@uniklinik-freiburg.de
authors.forename: Helmut R
authors.initials: HR
authors.lastname: Maecke
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Reubi
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D015282:Octreotide / Q000031:analogs & derivatives / Q000138:chemical synthesis; D004369:Pentetic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis; D010455:Peptides / Q000138:chemical synthesis; D049268:Positron-Emission Tomography; D011868:Radioisotopes / Q000627:therapeutic use*; D011877:Radionuclide Imaging / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D011878:Radiotherapy / Q000379:methods*; D017481:Receptors, Somatostatin / Q000528:radiation effects*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: C497824:111In-octreotide, DTPA(0)-; D010455:Peptides; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; D004369:Pentetic Acid; D015282:Octreotide