title: Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test.
abstract: Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broad-leaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.
authors.affiliation: National Taiwan University College of Medicine Animal Medicine Center, Taipei, Taiwan, ROC.
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: Wu
authors.forename: Fu-Chuo
authors.initials: FC
authors.lastname: Peng
authors.forename: Yung-Liang
authors.initials: YL
authors.lastname: Chen
authors.forename: Ching-Sung
authors.initials: CS
authors.lastname: Lee
authors.forename: Yi-Yuan
authors.initials: YY
authors.lastname: Yang
authors.forename: Ming-Yang
authors.initials: MY
authors.lastname: Yeh
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Liu
authors.forename: Jin-Biou
authors.initials: JB
authors.lastname: Chang
authors.forename: Rick Sai-Chuen
authors.initials: RS
authors.lastname: Wu
authors.forename: Chieh-Chih
authors.initials: CC
authors.lastname: Yu
authors.forename: Hsu-Feng
authors.initials: HF
authors.lastname: Lu
authors.forename: Jing-Gung
authors.initials: JG
authors.lastname: Chung
mesh_terms: D000818:Animals; D055491:Antrodia / Q000737:chemistry*; D016466:CHO Cells; D002869:Chromosome Aberrations / Q000139:chemically induced; D015169:Colony Count, Microbial; D045424:Complex Mixtures / Q000633:toxicity*; D006224:Cricetinae; D003412:Cricetulus; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000254:growth & development
chemical_list: D045424:Complex Mixtures; D009153:Mutagens