title: Painful bladder syndrome: management and effect on sexual function and quality of life.
abstract: OBJECTIVE
  Primary aim of this study was to evaluate the effect of our therapeutical management in patients with painful bladder syndrome (PBS)/interstitial cystitis (IC) on sexual function, quality of life and bladder symptoms using validated tools prospectively
  
  
  METHODS
  A prospective case controlled study The setting is a tertial referral centre. We included 69 patients with PBS/IC according to the National Institute of Diabetes and Kidney Disease (NIDDK) into this study All patients were managed applying determined therapeutical steps including tetracycline, bladder instillation consisting of heparine, local anaesthetic and natrium-bicarbonate, prednisolon and antihistaminics or instillation with DMSO. Sexual function, quality of life and symptoms were evaluated with validated tools FSFI, King's Health Questionnaire and visual analogue scale (VAS).
  
  
  RESULTS
  Pain, nocturia, urinary frequency and urgency were significantly reduced The King's Health questionnaire showed a significant improvement of all domains but emotions and sleep, and FSFI improved significantly in all domains but orgasm.
  
  
  CONCLUSIONS
  Patients with PBS/IC undergoing defined therapeutical steps including tetracycline, bladder instillation and anti-inflammatory agents improved significantly regarding sexual function, quality of life and symptoms. Long term follow-up has to prove this management as well as profound research on the unknown aetiology have to been done to determine even more efficient therapeutical regimes.
authors.affiliation: Department of Gynaecology, University Hospital of Bern, Switzerland.
authors.forename: Corina
authors.initials: C
authors.lastname: Schmid
authors.forename: Katrin
authors.initials: K
authors.lastname: Berger
authors.forename: Martin
authors.initials: M
authors.lastname: Müller
authors.forename: Johann
authors.initials: J
authors.lastname: Silke
authors.forename: Micheal David
authors.initials: MD
authors.lastname: Mueller
authors.forename: Annette
authors.initials: A
authors.lastname: Kuhn
mesh_terms: D000328:Adult; D000368:Aged; D000779:Anesthetics, Local / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D050034:Antidiuretic Agents / Q000627:therapeutic use; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D015331:Cohort Studies; D018856:Cystitis, Interstitial / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010147:Pain Measurement; D017699:Pelvic Pain / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D011788:Quality of Life; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy / Q000209:etiology*; D011795:Surveys and Questionnaires; D013557:Switzerland; D014563:Urodynamics / Q000187:drug effects; D016387:Women's Health; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D050034:Antidiuretic Agents; D018680:Cholinergic Antagonists