title: Multiple courses of stereotactic re-irradiation in recurrent oligodendroglioma: a case report.
abstract: BACKGROUND
  High grade gliomas are an insidious disease associated with an extremely poor prognosis. The role of re-irradiation for recurrent gliomas is unclear but several retrospective studies have indicated mild toxicity and modest outcomes with this regimen. With subsequent progression, it is unclear what options remain and more radiotherapy is rarely offered for fear of surpassing normal central nervous system tissue tolerance and causing significant side effects without significant benefit.
  
  
  METHODS
  In this report, we describe a 37-year-old Caucasian male initially diagnosed with a grade IV oligodendroglioma, who received multiple courses of re-irradiation and experienced a survival of 10 years with minimal cognitive or neurologic deficits.
  
  
  CONCLUSIONS
  Significant toxicity with multiple courses of radiation does not always occur. Re-irradiation should be considered in a salvage setting.
authors.affiliation: Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Ave, Room L-08, Box 0226, San Francisco, CA 94143, USA. shannonfogh@yahoo.com.
authors.forename: Shannon
authors.initials: S
authors.lastname: Fogh
authors.forename: Charles
authors.initials: C
authors.lastname: Glass
authors.forename: David W
authors.initials: DW
authors.lastname: Andrews
authors.forename: Maria
authors.initials: M
authors.lastname: Werner-Wasik