title: Prognostic relevance of limb shaking in symptomatic carotid artery occlusion.
abstract: BACKGROUND
  Internal carotid artery (ICA) occlusion, present in up to 15% of stroke patients, may cause low-flow transient ischemic attacks (TIAs) like limb shaking (LS) or retinal claudication (RC). Reliable data on the frequency of these phenomena and their potential prognostic relevance are still sparse.
  
  
  OBJECTIVE
  To provide more data about the frequency of low-flow TIA and investigate their influence on outcome.
  
  
  METHODS
  Medical records of 260 consecutive patients with symptomatic ICA occlusion were carefully reviewed (survey period: January 2000 to December 2006). Baseline stroke severity and outcome at 90 days and in the long term were assessed. All patients were specifically questioned about symptoms of LS and RC, were exposed to bright light (pupillary testing) and carefully watched during testing of posture/gait and early mobilization.
  
  
  RESULTS
  LS, RC or both occurred in 28.6, 9.5 and 2.7%, respectively, of patients eligible for a thorough assessment of low-flow TIAs (n = 147). An adverse outcome was more likely in patients with LS than in those without at day 90 (modified Ranking Scale ≥4, 45.2 vs. 21.9%, p = 0.005) and in the long term (median, 37 months) (52.7 vs. 23.1%, p < 0.001). In a multivariable analysis, prognostic relevance was found to be independent of baseline stroke severity (National Institutes of Health Stroke Scale). There was also a tendency towards higher rates of recurrent stroke and TIA in limb shakers. RC had no prognostic relevance regarding functional outcome and recurrent events.
  
  
  CONCLUSIONS
  In patients with ICA occlusion, RC and LS are more common than previously assumed. The presence of LS is associated with a worse outcome independent of initial stroke severity and patient characteristics.
authors.affiliation: Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Knoflach
authors.forename: Benjamin
authors.initials: B
authors.lastname: Matosevic
authors.forename: Michael
authors.initials: M
authors.lastname: Meinhart
authors.forename: Michael
authors.initials: M
authors.lastname: Rücker
authors.forename: Martin
authors.initials: M
authors.lastname: Furtner
authors.forename: Alexandra
authors.initials: A
authors.lastname: Zangerle
authors.forename: Barbara
authors.initials: B
authors.lastname: Prantl
authors.forename: Artur
authors.initials: A
authors.lastname: Mair
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmidauer
authors.forename: Stefan
authors.initials: S
authors.lastname: Kiechl
authors.forename: Johann
authors.initials: J
authors.lastname: Willeit
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000150:complications* / Q000175:diagnosis*; D002340:Carotid Artery Diseases / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012008:Recurrence; D012164:Retinal Diseases / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D014202:Tremor / Q000453:epidemiology / Q000209:etiology*