title: [Expression of p38MAPK in salivary adenoid cystic carcinoma and their significance].
abstract: OBJECTIVE
  To investigate the expression of p38 mitogen-activated protein kinase (p38MAPK) in salivary adenoid cystic carcinoma (SACC) tissues and their clinicopathologic significance.
  
  
  METHODS
  The protein and mRNA expressions of p38MAPK were examined by immunohistochemistry and in situ hybridization, respectively, in 52 cases of SACC and in 11 normal salivary gland tissues adjacent to the tumors on a tissue microarray platform.
  
  
  RESULTS
  The positive rate of p38MAPK protein expression in the paracancerous normal salivary gland tissues and that in SACC were 36.4% and 96.2%, respectively, showing a significant statistical difference (P < 0.01). The protein expression of p38MAPK was positively correlated with the lymph node metastasis and nerve involvement (P < 0.05). The positive rates of p38MAPK mRNA in the paracancerous tissues and in the SACC tissues were 45.5% and 94.2%, respectively, with a significant statistical difference (P < 0.01). The mRNA expression of p38MAPK was positively correlated with the lymph node metastasis and nerve involvement (P < 0.05). In the SACC, there was a notable positive correlation between the p38MAPK protein and mRNA expressions (r = 0.409, P < 0.01).
  
  
  CONCLUSIONS
  The expression of p38MAPK is up-regulated in salivary adenoid cystic carcinoma. p38MARK may be involved in the tumorigenesis, development and metastasis of this cancer.
authors.affiliation: Faculty of Stomatology, Anhui Medical College, Heifei 230601, China. dlz999@sohu.com
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wu
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000201:enzymology* / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000201:enzymology* / Q000473:pathology*; D012469:Salivary Glands / Q000201:enzymology; D015854:Up-Regulation; D048051:p38 Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D048051:p38 Mitogen-Activated Protein Kinases