title: Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device.
abstract: A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10-phenanthroline)-ruthenium(II) [Ru(phen)(3)(2+)] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 µg/mL was obtained. The detection limit was found to be 0.001 µg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.
authors.affiliation: Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al-Khod, 123, Oman. haiderl@squ.edu.om
authors.forename: Haider A J
authors.initials: HA
authors.lastname: Al Lawati
authors.forename: Zeiyana M
authors.initials: ZM
authors.lastname: Al Dahmani
authors.forename: Fakhr Eldin O
authors.initials: FE
authors.lastname: Suliman
authors.forename: Salma M Z
authors.initials: SM
authors.lastname: Al Kindy
authors.forename: Ali M
authors.initials: AM
authors.lastname: Al-Lawati
mesh_terms: D039563:Histamine H1 Antagonists, Non-Sedating / Q000032:analysis*; D049449:Luminescence; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D016593:Terfenadine / Q000031:analogs & derivatives* / Q000032:analysis
chemical_list: D039563:Histamine H1 Antagonists, Non-Sedating; D004364:Pharmaceutical Preparations; D016593:Terfenadine; C093230:fexofenadine