title: Rhabdomyolysis-induced acute kidney injury secondary to Anaplasma phagocytophilum and concomitant statin use.
abstract: We report the case of a patient with rhabdomyolysis-induced acute renal failure occurring in the setting of Anoplasma phagocytophilum infection based on the presence of morulae in neutrophils and concomitant statin use. Although the pathogenesis is unknown, we believe the combination of concurrent statin use in the setting of the infection promoted this complication. We describe proposed mechanisms including cytokine activation, alteration of the muscle membrane components, and ionic balance as contributing factors.
authors.affiliation: Department of Clinical Research Center, Marshfield Clinic Research Foundation, WI, USA.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Talsness
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Shukla
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Mazza
authors.forename: Steven H
authors.initials: SH
authors.lastname: Yale
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D000369:Aged, 80 and over; D041081:Anaplasma phagocytophilum; D016873:Ehrlichiosis / Q000150:complications* / Q000628:therapy; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D012206:Rhabdomyolysis / Q000150:complications* / Q000209:etiology / Q000628:therapy; D014922:Wisconsin
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors