title: Leukemic phase of follicular lymphomas: an atypical presentation.
abstract: Follicular lymphomas (FLs) are frequent B-cell derived malignancies, generally demonstrating an indolent evolution. Although circulating FL cells may be detected by high-resolution analysis, bloodstream involvement by FL cells is unusual. We observed in 10 patients a leukemic phase of FL at the onset of the disease. Six of them had concomitant lymph node involvement and all of them required treatment at diagnosis due to a high tumor burden, whereas four patients had pure FL-cell leukemia, which was associated with a more indolent clinical outcome. The detection of a leukemic phase should therefore be studied as a potential prognosis marker in further studies.
authors.affiliation: Université Paris Descartes, Paris, France.
authors.forename: Chadi
authors.initials: C
authors.lastname: Al-Nawakil
authors.forename: Olivier
authors.initials: O
authors.lastname: Kosmider
authors.forename: Marc-Henri
authors.initials: MH
authors.lastname: Stern
authors.forename: Elodie
authors.initials: E
authors.lastname: Manié
authors.forename: Valérie
authors.initials: V
authors.lastname: Bardet
authors.forename: Véronique
authors.initials: V
authors.lastname: Leblond
authors.forename: Sophie
authors.initials: S
authors.lastname: Park
authors.forename: François
authors.initials: F
authors.lastname: Dreyfus
authors.forename: Didier
authors.initials: D
authors.lastname: Bouscary
authors.forename: Jerome
authors.initials: J
authors.lastname: Tamburini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007938:Leukemia / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008224:Lymphoma, Follicular / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015260:Neprilysin / Q000378:metabolism; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D016133:Polymerase Chain Reaction; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D007143:Immunoglobulin Heavy Chains; D015514:Oncogene Proteins, Fusion; D019253:Proto-Oncogene Proteins c-bcl-2; D015260:Neprilysin