title: Osteolysis propensity among bilateral total hip arthroplasty patients.
abstract: Because some patients with high wear rates demonstrate extensive osteolysis whereas other patients with similarly high wear rates show little or no evidence of osteolysis, we hypothesized that both polyethylene wear and a patient-specific propensity mediate the development of osteolysis. We evaluated wear and osteolysis using computed tomography and radiographs among 46 patients who had undergone bilateral total hip arthroplasties (THAs). A radiographic patient-specific propensity for osteolysis associated with each THA was quantified by dividing the amount of osteolysis by the volumetric wear. Using a multivariate regression analysis to simultaneously consider the influence of polyethylene wear and patient propensity, we found that both factors are associated with the amount of osteolysis around a THA and that they appear to be of similar importance.
authors.affiliation: Anderson Orthopaedic Research Institute, Alexandria, Virginia 22307, USA.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Engh
authors.forename: Henry
authors.initials: H
authors.lastname: Ho
authors.forename: Cara C
authors.initials: CC
authors.lastname: Powers
authors.forename: Cathy
authors.initials: C
authors.lastname: Huynh
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Beykirch
authors.forename: Robert H
authors.initials: RH
authors.lastname: Hopper
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D003657:Decision Making; D005260:Female; D005271:Femur Head Necrosis / Q000601:surgery*; D006618:Hip Dislocation, Congenital / Q000601:surgery*; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging / Q000601:surgery*; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology*; D020959:Polyethylene / Q000009:adverse effects; D015995:Prevalence; D012044:Regression Analysis; D012086:Reoperation; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D020959:Polyethylene