title: [Detection and clinical significance of MCP-1 in gingival crevicular fluid from patients with chronic periodontitis].
abstract: OBJECTIVE
  To evaluate the concentration of monocyte chemoattractant protein-1 (MCP-1) in the gingival crevicular fluid from patients with chronic periodontitis and its correlation with clinic periodontal parameters as well as alkaline phosphates secretions.
  
  
  METHODS
  Gingival crevicular fluid (GCF) was collected with standardized filter strips from healthy control sites as well as periodontitis sites from chronic periodontitis patients before and after initial therapy, and the levels of MCP-1 and alkaline phosphatase were detected by ELISA. The data was analyzed with SPSS 11.0 software package.
  
  
  RESULTS
  Concentration of MCP-1 in GCF was significantly higher in chronic periodontitis patients, and decreased significantly after initial therapy, the variation of MCP-1 correlated positively with clinical parameters like plaque index(PLI), probing depth (PD), gingival index (GI), clinic attachment lost (CAL) as well as alkaline phosphatase secretion.
  
  
  CONCLUSIONS
  As an inflammatory chemotatic factor, MCP-1 in GCF may play an important role in occurrence and development of chronic periodontitis, and could be considered as a potential target for prevention and treatment of chronic periodontitis.
authors.affiliation: Department of Stomatology, First People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China. rainyzhangzun@hotmail.com
authors.forename: Zun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Sun
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Wang
mesh_terms: D000469:Alkaline Phosphatase; D018932:Chemokine CCL2; D055113:Chronic Periodontitis; D003774:Dental Plaque Index; D005883:Gingival Crevicular Fluid; D006801:Humans; D017622:Periodontal Attachment Loss; D010512:Periodontal Index; D010514:Periodontal Pocket; D010518:Periodontitis
chemical_list: D018932:Chemokine CCL2; D000469:Alkaline Phosphatase