title: [The influence of low-intensity laser radiation on the vascular endothelium function and the cytokine system in patients with chronic viral hepatitis].
abstract: The objective of the present work was to study the influence of low-intensity laser therapy on the cytokine system and the function of vascular endothelium in patients presenting with chronic viral hepatitis. The measurement of blood cytokine levels by an immunoenzyme assay revealed a decrease in the levels of anti-inflammatory IL-1-beta, IL-6, and TNF-alpha and a rise in proinflammatory IL-4 in the treated patients compared with the untreated ones. Medicamental therapy of chronic viral hepatitis did not cause a significant reduction in the plasma nitric oxide level whereas inclusion of low-intense laser irradiation in the combined treatment resulted in its normalization. It is concluded that the use of low-intense laser irradiation as a component of combined therapy of patients presenting with chronic viral hepatitis has marked beneficial effect on the cytokine system. Moreover, various methods of such laser therapy improve the functional activity of vascular endothelium and its NO-producing capacity.
authors.forename: N M
authors.initials: NM
authors.lastname: Burduli
authors.forename: A S
authors.initials: AS
authors.lastname: Krifaridi
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D016207:Cytokines / Q000097:blood*; D003627:Data Interpretation, Statistical; D004730:Endothelium, Vascular / Q000528:radiation effects*; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology / Q000532:radiotherapy*; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D009566:Nitrates; D009573:Nitrites