title: Genetic association of polymorphism rs1333049 with gout.
abstract: OBJECTIVE
  We suspect that genes or loci that contribute to coronary artery disease (CAD) may also play a role in the pathogenesis of gout, since hyperuricaemia leads to gout, and serum uric acid (SUA) levels are potential risk factors for CAD. The single nucleotide polymorphism (SNP) rs1333049 (C/G) on chromosome 9p21 has been implicated in previous studies to be associated with CAD. The aim of this study was to evaluate the relationship between this SNP and gout pathogenesis.
  
  
  METHODS
  Nine hundred Chinese Han were recruited for this study (461 gout patients and 439 gout-free individuals). The rs1333049 SNP and surrounding sequences were PCR sequenced.
  
  
  RESULTS
  There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls (χ(2) = 6.81, df = 2, P = 0.033 by genotype; χ(2) = 6.63, df = 1, P = 0.01 by allele). There was a significantly increased risk of gout in carriers of the CC genotype (odds ratio = 1.43, 95% CI 1.07, 1.91).
  
  
  CONCLUSIONS
  To the best of our knowledge, our findings are the first to establish an association of rs1333049 with gout in a Chinese Han population. Meanwhile, this SNP is homologous to miR-519 and miR-520.
authors.affiliation: Shandong Provincial Key Laboratory of Metabolic Diseases, Qingdao Key Laboratory of Common Diseases Gout Laboratory, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Meng
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.forename: Sirui
authors.initials: S
authors.lastname: Zhou
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Miao
authors.forename: Lin
authors.initials: L
authors.lastname: Han
authors.forename: Nan
authors.initials: N
authors.lastname: Chu
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
authors.forename: Changgui
authors.initials: C
authors.lastname: Li
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006073:Gout / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D012333:RNA, Messenger