title: Synthesis and antitumor activity of new retinobenzoic acids.
abstract: New retinobenzoic acid derivatives have been synthesized starting from 1,2,3,4-tetrahydro-1,1,2,4,4,6-hexamethylnaphthalene and 1,1,2,3,3-pentamethylindane. Four of the synthetic compounds displayed potent cytotoxic activities in vitro against human breast cancer and leukemic cell lines. Thus, these molecules can be further evaluated for the treatment of human leukemia and breast cancer.
authors.affiliation: Laboratory for Advanced Research in Natural and Synthetic Chemistry, V. G. Vaze College, Mumbai University, Mithagar road, Mumbai, India.
authors.forename: Reena P
authors.initials: RP
authors.lastname: Khandare
authors.forename: Kedar R
authors.initials: KR
authors.lastname: Vaze
authors.forename: Sujata V
authors.initials: SV
authors.lastname: Bhat
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D010795:Phthalic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010795:Phthalic Acids; D013764:Tetrahydronaphthalenes