title: An information-carrying and knowledge-producing molecular machine. A Monte-Carlo simulation.
abstract: The concept called Knowledge is a measure of the quality of genetically transferred information. Its usefulness is demonstrated quantitatively in a Monte-Carlo simulation on critical steps in a origin of life model. The model describes the origin of a bio-like genetic apparatus by a long sequence of physical-chemical steps: it starts with the presence of a self-replicating oligomer and a specifically structured environment in time and space that allow for the formation of aggregates such as assembler-hairpins-devices and, at a later stage, an assembler-hairpins-enzyme device-a first translation machine.
authors.affiliation: Biomedical Optics Research Laboratory, Clinic of Neonatology, University Hospital Zürich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland. c-k@gmx.ch
authors.forename: Christoph
authors.initials: C
authors.lastname: Kuhn
mesh_terms: D003198:Computer Simulation; D004777:Environment; D006801:Humans; D008962:Models, Theoretical; D009010:Monte Carlo Method; D000069497:Origin of Life; D011506:Proteins; D012313:RNA
chemical_list: D011506:Proteins; D012313:RNA