title: Effects of albusin B (a bacteriocin) of Ruminococcus albus 7 expressed by yeast on growth performance and intestinal absorption of broiler chickens--its potential role as an alternative to feed antibiotics.
abstract: BACKGROUND
  Bacteriocins with antimicrobial activity are considered as potential alternatives to antibiotics. The aim of this study was to investigate the effect of albusin B (bacteriocin) of Ruminococcus albus 7 expressed by yeast on the growth performance of broiler chickens. Ninety 1-day-old healthy broiler chickens were randomly divided into three groups: control, albusin B (2.5 g kg(-1)) and nosiheptide (2.5 mg kg(-1), antibiotic control). Growth performance and intestinal functions were measured at 5 weeks of age.
  
  
  RESULTS
  Albusin B-supplemented broilers showed increased body weight gain compared with control broilers (54.7 ± 5.3 vs 48.5 ± 6.1 g day(-1) per bird, P < 0.05). Broilers supplemented with nosiheptide had a less developed mucosal layer than broilers in the other two groups. Compared with the control group, broilers supplemented with albusin B or nosiheptide showed increased mRNA expression of sGLT1, GLUT2 and PEPT1 in the jejunum (P < 0.05). The faecal Lactobacillus count was higher in the albusin B group than in the other two groups (P < 0.05).
  
  
  CONCLUSIONS
  Albusin B supplementation increased intestinal absorption and elevated the faecal Lactobacillus count, thereby promoting the growth performance of broiler chickens. These improvements resulting from albusin B supplementation provide evidence of potential alternatives to antibiotics in broiler chicken feed.
authors.affiliation: Department of Animal Science, Chinese Culture University, Taipei, Taiwan.
authors.forename: Han-Tsung
authors.initials: HT
authors.lastname: Wang
authors.forename: Chi
authors.initials: C
authors.lastname: Yu
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Hsieh
authors.forename: Shiau-Wei
authors.initials: SW
authors.lastname: Chen
authors.forename: Bao-Ji
authors.initials: BJ
authors.lastname: Chen
authors.forename: Ching-Yi
authors.initials: CY
authors.lastname: Chen
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology; D030161:Avian Proteins / Q000235:genetics / Q000378:metabolism; D001430:Bacteriocins / Q000008:administration & dosage* / Q000009:adverse effects / Q000096:biosynthesis / Q000235:genetics; D002645:Chickens / Q000254:growth & development* / Q000378:metabolism / Q000382:microbiology*; D027342:Excitatory Amino Acid Transporter 2 / Q000235:genetics / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D005260:Female; D005503:Food Additives / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D051273:Glucose Transporter Type 2 / Q000235:genetics / Q000378:metabolism; D007421:Intestine, Small / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D007778:Lactobacillus / Q000187:drug effects / Q000302:isolation & purification; D008297:Male; D000074011:Peptide Transporter 1; D012333:RNA, Messenger / Q000378:metabolism; D011897:Random Allocation; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000096:biosynthesis; D045857:Ruminococcus / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D027981:Symporters / Q000235:genetics / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects; D015002:Yeast, Dried / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000900:Anti-Bacterial Agents; D030161:Avian Proteins; D001430:Bacteriocins; D027342:Excitatory Amino Acid Transporter 2; D005503:Food Additives; D051273:Glucose Transporter Type 2; D000074011:Peptide Transporter 1; D012333:RNA, Messenger; D011994:Recombinant Proteins; D027981:Symporters