title: Clinicopathological analysis of early-stage gastric cancers detected after successful eradication of Helicobacter pylori.
abstract: OBJECTIVE
  The results of a randomized controlled study and meta-analysis study have recently proved that Helicobacter pylori eradication has a preventive effect against the development of metachronous and primary gastric cancer. However, gastric cancer is sometimes detected after successful eradication. There is a lack of study about gastric cancers in eradicated patients. To clarify the characteristics of gastric cancers detected after H. pylori eradication, we analyzed the clinicopathological features of these cancers.
  
  
  METHODS
  The subjects were 18 early-stage gastric cancer specimens resected from 17 patients who had received successful eradication of H. pylori from February 1995 to March 2009. The control group consisted of 36 specimens from noneradicated patients with persistent H. pylori infection who were matched with the subjects in age, sex, and depth of invasion. Clinicopathological features and mucin phenotypes of gastric cancer were clinically and immunohistologically evaluated.
  
  
  RESULTS
  The average diameter of gastric cancer was smaller and Ki-67 index was lower in the eradication group. The morphological distribution of depression types was significantly lower in the control group. Immunohistochemical phenotyping revealed that 72.2% of the lesions in the eradicated group were complete gastric type or gastric predominant mixed type, whereas the percentages of gastric type and intestinal type in the control group were similar.
  
  
  CONCLUSIONS
  Our findings indicate that the clinicopathological characteristics of gastric cancers detected after H. pylori eradication are different from those of gastric cancers in patients with persistent H. pylori infection. H. pylori eradication may suppress intestinalization during the development of gastric cancer.
authors.affiliation: Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Kato
authors.forename: Masakazu
authors.initials: M
authors.lastname: Takahashi
authors.forename: Masahira
authors.initials: M
authors.lastname: Haneda
authors.forename: Keisuke
authors.initials: K
authors.lastname: Shinada
authors.forename: Urara
authors.initials: U
authors.lastname: Nishida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Norikazu
authors.initials: N
authors.lastname: Sonoda
authors.forename: Shoko
authors.initials: S
authors.lastname: Ono
authors.forename: Manabu
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Mori
authors.forename: Soichi
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Mabe
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Jun
authors.initials: J
authors.lastname: Moriya
authors.forename: Kanako
authors.initials: K
authors.lastname: Kubota
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsuno
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Shimoda
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Watanabe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology / Q000473:pathology*