title: Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis.
abstract: Cocoa products, which are rich sources of flavonoids, have been shown to reduce blood pressure and the risk of cardiovascular disease. Dark chocolate contains saturated fat and is a source of dietary calories; consequently, it is important to determine whether consumption of dark chocolate adversely affects the blood lipid profile. The objective was to examine the effects of dark chocolate/cocoa product consumption on the lipid profile using published trials. A detailed literature search was conducted via MEDLINE (from 1966 to May 2010), CENTRAL and ClinicalTrials.gov for randomized controlled clinical trials assessing the effects of flavanol-rich cocoa products or dark chocolate on lipid profile. The primary effect measure was the difference in means of the final measurements between the intervention and control groups. In all, 10 clinical trials consisting of 320 participants were included in the analysis. Treatment duration ranged from 2 to 12 weeks. Intervention with dark chocolate/cocoa products significantly reduced serum low-density lipoprotein (LDL) and total cholesterol (TC) levels (differences in means (95% CI) were -5.90 mg/dl (-10.47, -1.32 mg/dl) and -6.23 mg/dl (-11.60, -0.85 mg/dl), respectively). No statistically significant effects were observed for high-density lipoprotein (HDL) (difference in means (95% CI): -0.76 mg/dl (-3.02 to 1.51 mg/dl)) and triglyceride (TG) (-5.06 mg/dl (-13.45 to 3.32 mg/dl)). These data are consistent with beneficial effects of dark chocolate/cocoa products on total and LDL cholesterol and no major effects on HDL and TG in short-term intervention trials.
authors.affiliation: Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02120-1613, USA. otokede@hsph.harvard.edu
authors.forename: O A
authors.initials: OA
authors.lastname: Tokede
authors.forename: J M
authors.initials: JM
authors.lastname: Gaziano
authors.forename: L
authors.initials: L
authors.lastname: Djoussé
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002099:Cacao / Q000737:chemistry*; D002318:Cardiovascular Diseases / Q000188:drug therapy; D016208:Databases, Factual; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects*; D016032:Randomized Controlled Trials as Topic; D014280:Triglycerides / Q000097:blood
chemical_list: D005419:Flavonoids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides