title: Signaling mechanisms for chemotaxis.
abstract: Cells recognize external chemical gradients and translate these environmental cues into amplified intracellular signaling that results in elongated cell shape, actin polymerization toward the leading edge, and movement along the gradient. Mechanisms underlying chemotaxis are conserved evolutionarily from Dictyostelium amoeba to mammalian neutrophils. Recent studies have uncovered several parallel intracellular signaling pathways that crosstalk in chemotaxing cells. Here, we review these signaling mechanisms in Dictyostelium discoideum.
authors.affiliation: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Chen
authors.forename: Miho
authors.initials: M
authors.lastname: Iijima
mesh_terms: D002633:Chemotaxis; D004023:Dictyostelium / Q000378:metabolism / Q000502:physiology*; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D011953:Receptors, Cyclic AMP / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011953:Receptors, Cyclic AMP; D020962:Heterotrimeric GTP-Binding Proteins