title: A comparison of Jurkat cell-reactive anti-T lymphocyte globulin and fetal anti-thymocyte globulin preparations in the treatment of aplastic anemia.
abstract: OBJECTIVE
  The aim of this study was to investigate the success rate and effects on survival of different anti-thymocyte globulin (ATG) preparations in patients diagnosed with aplastic anemia.
  
  
  METHODS
  Of the total 24 patients included in the study, 12 were male and 12 female with a median age of 44 years (range 16-72). Nine patients received Lymphoglobulin®, 7 Thymoglobulin® and ATG-Fresenius® (ATG-F). There was no significant difference between the three treatment groups in terms of severity of aplastic anemia.
  
  
  RESULTS
  The estimated 6-month survival rates for ATG-F, Lymphoglobulin and Thymoglobulin groups were 42.9, 77.8 and 71.4%, respectively. The difference in overall survival rates between groups was not significant, most likely due to the low number of patients. The most striking result was that none of the patients in the ATG-F preparation group showed any response to treatment. The ATG-F group was found to have a significantly inferior response rate (p = 0.07).
  
  
  CONCLUSIONS
  Our data showed that none of the patients responded to ATG-F treatment. Hence, despite the small number of the patients, we recommend that ATG-F should not be used for treatment of severe aplastic anemia.
authors.affiliation: Department of Internal Medicine, Division of Hematology, Hacettepe University Hospital, Ankara, Turkey. dr.songul1978@yahoo.com
authors.forename: Songul
authors.initials: S
authors.lastname: Serefhanoglu
authors.forename: Yahya
authors.initials: Y
authors.lastname: Buyukasik
authors.forename: Tugrul
authors.initials: T
authors.lastname: Purnak
authors.forename: Hakan
authors.initials: H
authors.lastname: Goker
authors.forename: Nılgun
authors.initials: N
authors.lastname: Sayinalp
authors.forename: Ibrahim C
authors.initials: IC
authors.lastname: Haznedaroglu
authors.forename: Osman I
authors.initials: OI
authors.lastname: Ozcebe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000032:analysis / Q000276:immunology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D019169:Jurkat Cells / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013223:Statistics as Topic; D013601:T-Lymphocytes / Q000276:immunology*; D014421:Turkey; D055815:Young Adult
chemical_list: D000961:Antilymphocyte Serum; D007074:Immunoglobulin G