title: [Precocious pseudopuberty in a seven year-old girl due to estrogen treatment of labial adhesion].
abstract: Labial adhesions are well-known in prepubertal girls. We present a seven year-old girl treated with estrogen gel due to labial adhesion resulting in precocious pseudopuberty. Endocrine tests and bone age were normal. Symptoms regressed upon cessation of treatment. Labial adhesions often resolve spontaneously in early puberty. Precocious pseudopuberty is a well-known side effect to estrogen gel used in excess which should only be initiated in prepubertal girls with great caution and after careful consideration.
authors.affiliation: Børneafdelingen, Hillerød Hospital, 3400 Hillerød, Denmark. licle@noh.regionh.dk
authors.forename: Line
authors.initials: L
authors.lastname: Cleemann
authors.forename: Kirsten
authors.initials: K
authors.lastname: Holm
mesh_terms: D002648:Child; D004958:Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005782:Gels; D006801:Humans; D011629:Puberty, Precocious / Q000139:chemically induced; D000267:Tissue Adhesions / Q000188:drug therapy*; D014844:Vulva / Q000473:pathology*
chemical_list: D004967:Estrogens; D005782:Gels; D004958:Estradiol