title: Dacryoadenitis and diffuse orbital inflammation: unusual first presentations of Churg-Strauss syndrome.
abstract: Churg-Strauss syndrome (CSS) is a rare form of vasculitis involving small-to medium-sized blood vessels. CSS typically affects blood vessels of the lungs, gastrointestinal system, and peripheral nerves, but can also involve the heart, skin and kidneys. Here we present two CSS patients presenting with unusual ocular manifestations. Although ophthalmic complications remain relatively uncommon in vasculitides such as Churg-Strauss syndrome, these conditions should be considered in patients presenting with ocular manifestations and concurrent ear, nose and throat symptoms, arthralgia or with positive ANCA and eosinophilia.
authors.affiliation: St. Thomas' Hospital, Louise Coote Lupus Unit, London, United Kingdom. natasha.4.jordan@kcl.ac.uk
authors.forename: Natasha
authors.initials: N
authors.lastname: Jordan
authors.forename: Hema
authors.initials: H
authors.lastname: Verma
authors.forename: Anjali
authors.initials: A
authors.lastname: Ekbote
authors.forename: Shirish
authors.initials: S
authors.lastname: Sangle
authors.forename: David
authors.initials: D
authors.lastname: D'Cruz
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001707:Biopsy, Needle; D015267:Churg-Strauss Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D003607:Dacryocystitis / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009916:Orbital Diseases / Q000175:diagnosis*; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D008727:Methotrexate