title: Rotation thromboelastography (ROTEM) parameters are influenced by age, gender, and oral contraception.
abstract: Rotation thromboelastography (ROTEM) is a screening method that allows the rapid detection of plasma- and platelet-related haemostatic abnormalities. To use this procedure more efficiently, reference values depending on gender, age, and oral contraception are required. In this study, five cohorts of healthy subjects were examined by ROTEM upon activation of the extrinsic or intrinsic pathway of coagulation, or recalcification alone. The cohorts comprised male subjects below (1) and above (2) 45 years of age, female subjects below 45 years of age with (3) or without (4) oral contraception, and female subjects above 45 years (5) without hormone replacement therapy. A significant influence of gender, age, and oral contraception on parameters determined by ROTEM was observed. Thus, adjustment for age, gender, and oral contraception is required when ROTEM is used to screen for distinct abnormalities of haemostasis.
authors.affiliation: LaboMed Coagulation Centre, Tauentzienstrasse 7, Berlin, Germany. sucker@labomed.de
authors.forename: C
authors.initials: C
authors.lastname: Sucker
authors.forename: K
authors.initials: K
authors.lastname: Tharra
authors.forename: J
authors.initials: J
authors.lastname: Litmathe
authors.forename: R E
authors.initials: RE
authors.lastname: Scharf
authors.forename: R B
authors.initials: RB
authors.lastname: Zotz
mesh_terms: D000328:Adult; D000367:Age Factors; D001777:Blood Coagulation / Q000187:drug effects*; D015331:Cohort Studies; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D020249:Hormone Replacement Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012737:Sex Factors; D013916:Thrombelastography / Q000379:methods* / Q000592:standards
chemical_list: D003276:Contraceptives, Oral