title: [Diagnostic value of alginate test in gastroesophageal reflux disease].
abstract: OBJECTIVE
  To evaluate the diagnostic accuracy of single dose of gaviscon (the alginates test) in detecting gastroesophageal reflux disease (GERD) in patients with heartburn symptoms.
  
  
  METHODS
  123 patients (male 46, female 77, age 43.6 +/- 15.5 years) with symptoms suggestive of GERD were investigated. Symptom response to the alginates test compared in GERD positive and GERD negative patients according traditional diagnostic criteria of GERD (upper endoscopy, 24-hr pH-monitoring, esophageal manometry, response to treatment with PPIs).
  
  
  RESULTS
  Of 91 (78.9%) patients with positive alginates test, 87 were classified as GERD positive and 4 as GERD negative. Of 32 (26%) patients with negative alginates test, 29 were GERD negative and 3 GERD positive. The results providing a sensitivity of alginates test of 96.7% and a specificity of 87.7%.
  
  
  CONCLUSIONS
  The alginates test is sensitive and specific for diagnosing GERD in patients with typical GERD symptoms.
authors.forename: D S
authors.initials: DS
authors.lastname: Bordin
authors.forename: A A
authors.initials: AA
authors.lastname: Masharova
authors.forename: V N
authors.initials: VN
authors.lastname: Droxzdov
authors.forename: L D
authors.initials: LD
authors.lastname: Firsova
authors.forename: T S
authors.initials: TS
authors.lastname: Kozhurina
mesh_terms: D000328:Adult; D000464:Alginates / Q000008:administration & dosage*; D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000863:Antacids / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000008:administration & dosage; D004338:Drug Combinations; D016145:Endoscopy, Digestive System / Q000379:methods; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D020723:Glucuronic Acid / Q000008:administration & dosage; D006603:Hexuronic Acids / Q000008:administration & dosage; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D012824:Silicic Acid / Q000008:administration & dosage*; D017693:Sodium Bicarbonate / Q000008:administration & dosage*
chemical_list: D000464:Alginates; D000863:Antacids; D001672:Biocompatible Materials; D004338:Drug Combinations; D006603:Hexuronic Acids; D012824:Silicic Acid; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; D020723:Glucuronic Acid; D017693:Sodium Bicarbonate