title: Association of human adenovirus-36 in overweight Korean adults.
abstract: BACKGROUND
  Although human adenovirus-36 (Ad-36) has been reported to be associated with obesity in US adults and children, Korean children and the Italian population, the association has not been found in Dutch or Belgian populations or in US military subjects. Therefore, we examined whether Ad-36 infection is associated with obesity in Korean adults.
  
  
  METHODS
  A total of 540 age- and sex-matched individuals, who were normal weight, overweight or obese, were selected from participants in routine health examinations at the Ewha Womans University Medical Center. Overweight participants were defined as those with a body mass index (BMI) of 23 ≤ BMI<25 kg m(-2) and obese subjects were those with BMI ≥ 25 kg m(-2), according to the International Obesity Task Force definition. Ad-36 antibody was measured using a serum neutralization assay.
  
  
  RESULTS
  Although more overweight participants than normal or obese subjects tested positive for the Ad-36 antibody (40%, 32.8% and 30%, respectively), the differences were not significant. The participants who tested positive for Ad-36 antibody had lower levels of triglycerides (TG) in each of the three groups, higher total cholesterol (TC) in the obese group and higher high-density lipoprotein-cholesterol (HDL-C) in both the normal and obese groups. The odds ratio (OR) for Ad-36 antibody positivity was greater in overweight than in normal subjects (OR=2.03; 95% confidence interval (CI), 1.16-3.55) after adjusting for age, sex and waist circumference. However, this OR was non-significant in the obese group (OR=1.56; 95% CI, 0.67-3.67).
  
  
  CONCLUSIONS
  Ad-36 seems to be strongly associated with overweight, but not obese, Korean adults.
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, Korea.
authors.forename: H-N
authors.initials: HN
authors.lastname: Na
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
authors.forename: K W
authors.initials: KW
authors.lastname: Shim
authors.forename: H
authors.initials: H
authors.lastname: Kimm
authors.forename: S H
authors.initials: SH
authors.lastname: Jee
authors.forename: I
authors.initials: I
authors.lastname: Jo
authors.forename: J-H
authors.initials: JH
authors.lastname: Nam
mesh_terms: D000258:Adenovirus Infections, Human / Q000097:blood / Q000150:complications* / Q000453:epidemiology* / Q000276:immunology; D000260:Adenoviruses, Human / Q000276:immunology; D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000821:virology; D016017:Odds Ratio; D050177:Overweight / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D014280:Triglycerides