title: Endocytic trafficking and Wnt/β-catenin signaling.
abstract: Several mechanisms function in the endocytic regulation of the Wnt/β-catenin signaling pathway to promote or interrupt the progression of critical cellular processes during embryonic development or disease progression. Endocytosis was initially associated with the formation of a morphogen gradient of Wnt/β-catenin signaling, but current studies have documented its role in defining signal intensity and propagation. Although the exact parameters that define and dictate the internalization of Wnt receptors and co-receptors via clathrin- or caveolae-mediated endocytosis remain unclear, new studies indicate that the trafficking of the signaling pool of the dual-function protein beta-catenin from sites of cell-cell contacts serve as a mechanism to finely tune the outcome of the Wnt/β-catenin signaling. This review discusses the endocytic regulation of Wnt/β-catenin signaling that occurs at the cell surface as well as within the cell.
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556-0369, USA.
authors.forename: Oscar
authors.initials: O
authors.lastname: Pellón-Cárdenas
authors.forename: Jill
authors.initials: J
authors.lastname: Schweitzer
authors.forename: Crislyn
authors.initials: C
authors.lastname: D'Souza-Schorey
mesh_terms: D015815:Cell Adhesion Molecules / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D021381:Protein Transport; D015398:Signal Transduction / Q000502:physiology; D051153:Wnt Proteins / Q000502:physiology*; D051176:beta Catenin / Q000502:physiology*
chemical_list: D015815:Cell Adhesion Molecules; D051153:Wnt Proteins; D051176:beta Catenin