title: The Response of Pseudomonas aeruginosa PAO1 Efflux Pump-Defective Mutants to N-Octanoyl-L-Homoserine Lactone.
abstract: N-Octanoyl-L-homoserine lactone (C8-HSL) is an acyl-homoserine-lactone signal utilized in the quorum-sensing (QS) systems of Burkholderia cenocepacia and other bacterial species. Although also produced by Pseudomonas aeruginosa, its role in this species has not been elucidated. Here, we report that C8-HSL modulated antibiotic resistance and pyocyanin production in a P. aeruginosa efflux pump-deficient mutant. The rhl/las quorum-sensing system and qscR gene were both shown to be nonessential in the C8-HSL-induced changes in ofloxacin resistance, suggesting that P. aeruginosa possesses a distinct pathway to respond to C8-HSL.
authors.affiliation: Institute of Life and Environmental Sciences, University of Tsukuba.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yawata
authors.forename: Hideaki
authors.initials: H
authors.lastname: Maseda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okabe
authors.forename: Akinobu
authors.initials: A
authors.lastname: Ito
authors.forename: Isao
authors.initials: I
authors.lastname: Sawada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kurashima
authors.forename: Hiroo
authors.initials: H
authors.lastname: Uchiyama
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Nomura