title: Familial Hodgkin's lymphoma in Scandinavia.
abstract: From 2005 to 2010, eight families with clustering of Hodgkin's lymphoma and other lymphoproliferative disorders were found: Hodgkin's lymphoma 9 cases, chronic lymphocytic leukemia 8, non-Hodgkin's lymphoma 3, and multiple myeloma 1 case. Seven cases of Hodgkin's lymphoma, all males, were seen in pleiotropic pairs of affected family members from two successive generations; two patients were sisters. Five of the seven pairs showed sign of anticipation. The 7 males with Hodgkin's lymphoma were found in 5 patrilineal pairs and 2 matrilineal pairs; 6 parent-offspring pairs and 1 uncle-nephew pair. In contrast to the matrilineal pairs, all patrilineal pairs, apart from one family with an only child, had healthy older siblings in accordance with a birth-order effect. The association among Hodgkin's lymphoma, males, and other lymphoproliferative disorders undoubtedly reflects genotypic traits of the susceptibility. A non-Mendelian segregation is discussed comprising genomic parental imprinting and incomplete penetrance susceptibility in both familial and solitary cases.
authors.affiliation: Department of Hematology, Oslo University Hospital, Aker, Trondheimsveien 235, NO 0514 Oslo, Norway. viggo.jonsson@medisin.uio.no
authors.forename: Viggo
authors.initials: V
authors.lastname: Jønsson
authors.forename: Haneef
authors.initials: H
authors.lastname: Awan
authors.forename: Emil
authors.initials: E
authors.lastname: Nyquist
authors.forename: Martin
authors.initials: M
authors.lastname: Maisenhølder
authors.forename: Tom B
authors.initials: TB
authors.lastname: Johannesen
authors.forename: Bernt
authors.initials: B
authors.lastname: Ly
authors.forename: Geir E
authors.initials: GE
authors.lastname: Tjønnfjord
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012537:Scandinavian and Nordic Countries; D055815:Young Adult