title: Chromosomally integrated human herpesvirus-6 in kidney transplant recipients.
abstract: BACKGROUND
  During primary infection, human herpesvirus-6 (HHV-6) may become integrated into the chromosome. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken as active infection and treated unnecessarily. The prevalence of CIHHV-6 in kidney transplant recipients is not known.
  
  
  METHODS
  We performed quantitative HHV-6 polymerase chain reaction assay on whole blood samples collected from 47 kidney recipients. CIHHV-6 was defined as HHV-6 DNA levels >1 × 10(6) genomes/mL.
  
  
  RESULTS
  One of 47 kidney recipients was found to have CIHHV-6. The prevalence of CIHHV-6 was calculated at 2.1% (95% confidence interval, <0.01-12.1%). Despite an increase in HHV-6 DNA level after transplant, the patient did not develop clinical HHV-6 disease.
  
  
  CONCLUSIONS
  CIHHV-6 may be observed in kidney transplant recipients. Clinicians should be aware of this entity so as not to provide unnecessary treatment to asymptomatic patients with CIHHV-6.
authors.affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, MN, USA.
authors.forename: Sang-Oh
authors.initials: SO
authors.lastname: Lee
authors.forename: Robert A
authors.initials: RA
authors.lastname: Brown
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Eid
authors.forename: Raymund R
authors.initials: RR
authors.lastname: Razonable
mesh_terms: D000328:Adult; D000368:Aged; D002877:Chromosomes, Human / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D015654:Herpesvirus 6, Human / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011379:Prognosis; D019349:Roseolovirus Infections / Q000453:epidemiology* / Q000235:genetics* / Q000821:virology; D016662:Virus Integration / Q000235:genetics*; D055815:Young Adult
chemical_list: D004279:DNA, Viral