title: Paraoxonase-1 is not affected in polycystic ovary syndrome without metabolic syndrome and insulin resistance, but oxidative stress is altered.
abstract: Paraoxonase-1 (PON1) activity is decreased in polycystic ovary syndrome (PCOS) having metabolic syndrome (MetS) or insulin resistance (IR). We aimed to assess PON1 activity and oxidative stress in PCOS without MetS or IR. Metabolic and hormonal parameters, high-sensitive C-reactive protein (hs-CRP), oxidative stress parameters (total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index (OSI), lipid hydroperoxide (LOOH), total free sulfhydryl (--SH) groups), PON and arylesterase were analyzed in 30 normal weighed patients with PCOS without MetS or IR and 20 normal controls. Hs-CRP, PON, arylesterase, and TAS levels of PCOS and control groups were similar. LOOH, TOS, and OSI of PCOS group were higher than in the controls (p < 0.05; p < 0.001, and p < 0.001, respectively). - SH group levels showed a positive correlation with free testosterone (fT). TOS positively correlated with free androgen index (FAI), body mass index (BMI), waist-to-hip ratio (WHR), LOOH, and OSI. This study showed that oxidative stress is increased in PCOS even in the absence of MetS or IR. PON1 activity appears not to be affected in PCOS without MetS and IR. Several metabolic and antropometric risk factors may aggravate this altered oxidative state in PCOS.
authors.affiliation: Department of Endocrinology, Harran University School of Medicine, Sanliurfa, Turkey. aysenurizol@yahoo.com
authors.forename: Ayse Nur
authors.initials: AN
authors.lastname: Torun
authors.forename: Mehmet
authors.initials: M
authors.lastname: Vural
authors.forename: Hasan
authors.initials: H
authors.lastname: Cece
authors.forename: Hakan
authors.initials: H
authors.lastname: Camuzcuoglu
authors.forename: Harun
authors.initials: H
authors.lastname: Toy
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D004789:Enzyme Activation / Q000502:physiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000097:blood; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D008055:Lipids; D013438:Sulfhydryl Compounds; D013739:Testosterone; D002097:C-Reactive Protein; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human