title: Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration.
abstract: Parkinson's disease is associated with the loss of dopaminergic neurons in the substantia nigra and decreased striatal dopamine levels. We now report that caffeic acid phenethyl ester (CAPE), an active component of propolis, attenuated dopaminergic neurodegeneration and dopamine loss in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease. The neuroprotective effect of CAPE was associated with marked reductions in inducible nitric oxide synthase (iNOS) and caspase 1 expression. Additionally, CAPE inhibited MPP+-induced neurotoxicity in vitro and directly inhibited MPP+-induced release of cytochrome c and apoptosis inducing factor (AIF) from mitochondria. Thus, CAPE may have beneficial effects in slowing or preventing the progression of Parkinson's disease and other neurodegenerative disorders.
authors.affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: C V
authors.initials: CV
authors.lastname: Fontanilla
authors.forename: Z
authors.initials: Z
authors.lastname: Ma
authors.forename: X
authors.initials: X
authors.lastname: Wei
authors.forename: J
authors.initials: J
authors.lastname: Klotsche
authors.forename: L
authors.initials: L
authors.lastname: Zhao
authors.forename: P
authors.initials: P
authors.lastname: Wisniowski
authors.forename: R C
authors.initials: RC
authors.lastname: Dodel
authors.forename: M R
authors.initials: MR
authors.lastname: Farlow
authors.forename: W H
authors.initials: WH
authors.lastname: Oertel
authors.forename: Y
authors.initials: Y
authors.lastname: Du
mesh_terms: D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002109:Caffeic Acids / Q000494:pharmacology*; D007150:Immunohistochemistry; D020267:MPTP Poisoning / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D002109:Caffeic Acids; D018696:Neuroprotective Agents; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol