title: [Correlation between serum uric acid levels and obstructive sleep apnea/hypopnea syndrome in children].
abstract: OBJECTIVE
  To explore the level of serum uric acid (UA) in children with obstructive sleep apnea/hypopnea syndrome (OSAHS).
  
  
  METHODS
  Between Sep. 2008 and Mar. 2010, 138 children with OSAHS were enrolled in study group. Sixty-five children with accessory auricle or ptosis of upper lid were enrolled into the control group. Furthermore, according to apnea/hypopnea index (AHI) or obstructive apnea index (OAI) the study group was further divided into three subgroups (mild, moderate and severe group). At last, the study group and control group were divided into two groups according to the body mass index (BMI), separately. The fasting serum UA level was compared among the different groups. Then the correlation between the serum UA level and AHI, BMI, oxygen desaturation index, least arterial oxygen saturation (LSaO(2)) and the percentage of total sleep time with arterial oxygen saturation < 0.92 was also analyzed in OSAHS children with or without overweight and obesity respectively.
  
  
  RESULTS
  The difference of serum UA level between the study group and control group (z = -0.443), and the difference among the three groups (χ(2) = 1.241) was not significant(P > 0.05). The serum UA level in overweight and obese children [study group, 273.0 (238.3 - 357.3); control group, 298.0 (253.0 - 336.0)] was significantly higher than that in children with normal BMI [study group, 246.5(215.8 - 300.0); control group, 266.0 (224.0 - 303.3)] (z = -2.084, -2.214, P < 0.05). That serum UA level did not correlate with the above index of OSAHS was observed in children with or without overweight and obesity in study group (P > 0.05).
  
  
  CONCLUSIONS
  Findings of higher serum UA level were not observed in children with OSAHS. There was no correlation between serum UA level and the above indices of OSAHS. The serum UA level in overweight and obese children was significantly higher than that in children with normal BMI.
authors.affiliation: Department of Otorhinolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou 510120, China.
authors.forename: Zhen-yun
authors.initials: ZY
authors.lastname: Huang
authors.forename: Da-bo
authors.initials: DB
authors.lastname: Liu
authors.forename: Gen-ping
authors.initials: GP
authors.lastname: Wan
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Zhong
authors.forename: Zong-yu
authors.initials: ZY
authors.lastname: Tan
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Jia-jian
authors.initials: JJ
authors.lastname: Xu
authors.forename: Jian-bo
authors.initials: JB
authors.lastname: Shao
authors.forename: Shu-yao
authors.initials: SY
authors.lastname: Qiu
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D006801:Humans; D020181:Sleep Apnea, Obstructive / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid