title: [A case of hepatocellular carcinoma diagnosed based on the result of a bone biopsy, in which the primary hepatocellular carcinoma was identified in the liver 14 months after the initial diagnosis].
abstract: A 64-year-old man complained of pain in his left humerus. A histopathological examination of biopsy specimens taken from the lesion revealed a hepatocellular carcinoma. No primary hepatic lesion was revealed in a subsequent examination performed at this time. Enhanced computed tomography examination of the abdomen 14 months later, showed a nodular lesion, approximately 15 mm in diameter, therefore a partial hepatectomy was performed. The lesion was histopathologically diagnosed as a moderately-poorly differentiated hepatocellular carcinoma. The inability to identify the primary hepatocellular carcinoma is quite rare, and the present case may be the first report of the discovery of the primary hepatocellular cancer after the diagnosis of a secondary lesion.
authors.affiliation: First Department of Internal Medicine, Sapporo Medical University. kubo-t@grape.plala.or.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kubo
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Akutsu
authors.forename: Hideki
authors.initials: H
authors.lastname: Wakasugi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shitani
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Ohashi
authors.forename: Kotoe
authors.initials: K
authors.lastname: Kashiwaya
authors.forename: Masayo
authors.initials: M
authors.lastname: Hosokawa
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Takagi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sasaki
authors.forename: Toru
authors.initials: T
authors.lastname: Mizuguchi
authors.forename: Kouichi
authors.initials: K
authors.lastname: Hirata
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Shinomura
mesh_terms: D001706:Biopsy; D001859:Bone Neoplasms / Q000556:secondary*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors