title: [My hybrid carrier of clinical pathologist].
abstract: In this review, I showed a brief summary of my carrier in multiple special fields (clinical pathologist, anatomical pathologist of lung, respiratory physician and infection control doctor), my studies and my own view of laboratory medicine. We chiefly study pathology of the lung, especially about type II pneumocytes. Type II pneumocytes had abundant surface coat on the apical surface containing a specific carbohydrate structure of Thomsen-Friedenreich (TF) antigen. TF antigen is a marker of type II pneumocytes beyond animal species, and can be used for evaluating activity of various interstitial pneumonia as type II pneumocyte index (number/lmm alveolar length). Three dimensional views generated from thick sections of ordinary processed paraffin blocks showed new information of normal and abnormal lung morphology. Type II pneumocytes linearly located along the elastic fibers forming framework of polygonal alveoli, and in usual interstitial pneumonia, destruction of these elastic fibers were observed. In Japan, roles of a clinical pathologist are not definite as a radiologist, and clinical laboratory in a hospital is recognized as a section only performing blood and chemical tests. Evaluation of the data and participation in diagnosis were not requested. In future, medical doctors devote themselves to treat patients, and clinical pathologists and laboratory technicians have to help the doctors in diagnostic process. Routine tests (blood and urine) are most frequently performed in clinical medicine, but the data are not adequately used. Therefore, a system is necessary for interpreting routine tests and reporting them to other medical staffs.
authors.affiliation: Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto 390-8621, Japan. thondat@shinshu-u.ac.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Honda
mesh_terms: D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D017053:Infection Control; D008168:Lung / Q000473:pathology; D010338:Pathology, Clinical / Q000639:trends*; D011650:Pulmonary Alveoli / Q000166:cytology / Q000473:pathology; D015272:Pulmonary Medicine / Q000639:trends