title: Biomarkers for cognitive aging part II: oxidative stress, cognitive assessments, and medication adherence.
abstract: The purpose of this study was to further examine potential biomarkers of cognitive aging by looking at the associations among oxidative stress, cognitive abilities, and medication adherence in a community-based sample of middle-aged and older adults (n = 42; mean age = 69 years) prescribed at least one medication for hypertension. In addition to measures described in Part I, "Biomarkers for Cognitive Aging," a 12-hr urine collection for F(2)-isoprostanes served as an indicator of oxidative stress. Participants completed a battery of cognitive assessments and 8 weeks of electronic medication monitoring for adherence to one antihypertensive agent. Oxidative stress was significantly associated with logical memory, immediate (r = -.38, p < .01) and delayed recall (r = -.42, p < .01), and recognition memory (r = -.42, p < .01) from the Wechsler Memory Scale III, number of perseveration errors (r = .26, p < .05) and categories achieved (r = -.26, p < .01) on the Wisconsin Card Sorting Test (WSCT), and medication adherence (r = -.34, p <.05). Findings indicate that a biomarker of oxidative stress, F(2)-isoprostanes corrected for vitamin E, is significantly associated with cognitive measures and a functional outcome.
authors.affiliation: College of Nursing, University of Arizona, Tucson, AZ 85721, USA. insel@email.arizona.edu
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Insel
authors.forename: Ida M
authors.initials: IM
authors.lastname: Moore
authors.forename: Amy N
authors.initials: AN
authors.lastname: Vidrine
authors.forename: David W
authors.initials: DW
authors.lastname: Montgomery
mesh_terms: D000368:Aged; D000375:Aging; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000652:urine*; D003071:Cognition; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D028421:Isoprostanes / Q000652:urine; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010349:Patient Compliance
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D028421:Isoprostanes; D003404:Creatinine