title: Immunohistochemical expression of the C-fos protein in preneoplastic and neoplastic lesions during hepatocarcinogenesis in rats.
abstract: We performed an immunohistochemical study of the c-FOS protein, in the preneoplastic and neoplastic liver lesions in rats. The majority of the lesions at all stages contained an average of 50 to 60 percent of c-FOS immunopositive nuclei: This contrasted with the non-involved parenchyma, which exhibited a low incidence of positivity (less than 10 percent). No relation with proliferation or apoptosis was observed in the lesions, whereas the c-FOS protein was overexpressed within a few hours of partial hepatectomy. Moreover, our results indicate that increased c-FOS protein content is insufficient to elicit full malignancy.
authors.affiliation: UNIV LIBRE BRUXELLES,IRIBHN,UNITE BIOL,B-1070 BRUSSELS,BELGIUM.
authors.forename: K
authors.initials: K
authors.lastname: Alexandre
authors.forename: D
authors.initials: D
authors.lastname: Fokan
authors.forename: P
authors.initials: P
authors.lastname: Galand