title: Isl1 is required for multiple aspects of motor neuron development.
abstract: The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons.
authors.affiliation: Key Laboratory of Arrhythmia, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
authors.forename: Xingqun
authors.initials: X
authors.lastname: Liang
authors.forename: Mi-Ryoung
authors.initials: MR
authors.lastname: Song
authors.forename: ZengGuang
authors.initials: Z
authors.lastname: Xu
authors.forename: Guillermo M
authors.initials: GM
authors.lastname: Lanuza
authors.forename: Yali
authors.initials: Y
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Zhuang
authors.forename: Yihan
authors.initials: Y
authors.lastname: Chen
authors.forename: Samuel L
authors.initials: SL
authors.lastname: Pfaff
authors.forename: Sylvia M
authors.initials: SM
authors.lastname: Evans
authors.forename: Yunfu
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D047108:Embryonic Development / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D060850:LIM-Homeodomain Proteins; D051379:Mice; D008822:Mice, Transgenic; D009046:Motor Neurons / Q000378:metabolism*; D013116:Spinal Cord / Q000196:embryology / Q000378:metabolism*; D014157:Transcription Factors
chemical_list: D018398:Homeodomain Proteins; D060850:LIM-Homeodomain Proteins; D014157:Transcription Factors; C063843:insulin gene enhancer binding protein Isl-1