title: Sheehan's syndrome with central diabetes insipidus.
abstract: Sheehan's syndrome refers to the occurrence of hypopituitarism after delivery, usually preceded by postpartum hemorrhage. The condition still continues to be a common cause of hypopituitarism in developing countries like India. The disorder usually presents with anterior pituitary failure with preservation of posterior pituitary functions. Posterior pituitary dysfunction in the form of central diabetes insipidus is rare in patients with Sheehan's syndrome. We describe the clinical course of a young lady who after her sixth childbirth developed severe postpartum hemorrhage followed by development of panhypopituitarism which was confirmed by hormonal investigation and demonstration of empty sella on imaging. In addition, she developed Polyuria. The water deprivation test and response to vasopressin test results indicated central diabetes insipidus. She needed oral desmopressin on a continuous basis to control polyuria.
authors.affiliation: Department of Endocrinology, Srinagar, Jammu and Kashmir, India.
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Laway
authors.forename: Shahnaz Ahmad
authors.initials: SA
authors.lastname: Mir
authors.forename: Mohd Iqbal
authors.initials: MI
authors.lastname: Dar
authors.forename: Abdul Hamid
authors.initials: AH
authors.lastname: Zargar
mesh_terms: D000328:Adult; D020790:Diabetes Insipidus, Neurogenic / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000150:complications* / Q000175:diagnosis; D006473:Postpartum Hemorrhage / Q000209:etiology*; D011247:Pregnancy