title: Surgical management of buruli ulcer disease: a four-year experience from four endemic districts in ghana.
abstract: BACKGROUND
  Mycobacterium ulcerans (MU) disease causes extensive destruction of tissues leaving large ulcers on the body. Management which consisted of surgical excision of the lesions is gradually being replaced with chemotherapy.
  
  
  OBJECTIVE
  To study the impact on surgery of prior treatment of MU disease with rifampicin and streptomycin.
  
  
  METHODS
  Retrospective, from September 2004 to September 2009.
  
  
  METHODS
  Asunafo, Amansie West, Ahafo Ano and Amansie Central districts of Ghana.
  
  
  METHODS
  Patients who have completed 8 weeks or a minimum of 4 weeks treatment with rifampicin and streptomycin but have unhealed lesions were selected for surgery.
  
  
  RESULTS
  132 patients had surgery for MU disease; 51 at Tepa (Ahafo Ano); 36 at Agroyesum (Amansie West); 16 from Jacobu (Amansie Central); 29 from Goaso (Asunafo) districts. Their ages ranged from 4 to 98 years, with mean age of 29.90 years, standard deviation of 20.74. Sites involved were: head and neck 1 (0.74%), upper limb 40 (29.63%), lower limb 92 (68.15%), trunk 2 (1.48%) (N=135). The clinical forms were: papule 1 (0.74%), nodule 2 (1.48%), oedematous lesion 4 (2.96%), osteomyelitis 2 (1.48%), ulcers 124 (91.85%), contractures 2 (1.48%). 139 surgical procedures were performed: excision 25 (18.11), skin grafting 36 (26.1%), excision and skin grafting 54 (39.1%), debridem net 10 (7.2%), sequestrectomy 2 (1.4%), regrafting 10 (7.2%), release of contractures 2 (1.4%).
  
  
  CONCLUSIONS
  Treatment of MU disease with rifampicin and streptomycin improved the condition and minimised the extent of surgery. Combination of surgery and antibiotics is necessary to prevent the development contractures.
authors.affiliation: Department of Surgery, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. aduemmanuel@hotmail.com
authors.forename: Ejk
authors.initials: E
authors.lastname: Adu
authors.forename: E
authors.initials: E
authors.lastname: Ampadu
authors.forename: D
authors.initials: D
authors.lastname: Acheampong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054312:Buruli Ulcer / Q000453:epidemiology / Q000382:microbiology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D062109:Dermatologic Surgical Procedures / Q000379:methods*; D019353:Endemic Diseases; D005260:Female; D005869:Ghana / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000453:epidemiology / Q000382:microbiology / Q000601:surgery*; D019911:Mycobacterium ulcerans / Q000302:isolation & purification*; D015995:Prevalence; D012189:Retrospective Studies; D012867:Skin / Q000382:microbiology*; D055815:Young Adult