title: Role of adenosine A(2B) receptors in inflammation.
abstract: Recent progress in our understanding of the unique role of A(2B) receptors in the regulation of inflammation, immunity, and tissue repair was considerably facilitated with the introduction of new pharmacological and genetic tools. However, it also led to seemingly conflicting conclusions on the role of A(2B) adenosine receptors in inflammation with some publications indicating proinflammatory effects and others suggesting the opposite. This chapter reviews the functions of A(2B) receptors in various cell types related to inflammation and integrated effects of A(2B) receptor modulation in several animal models of inflammation. It is argued that translation of current findings into novel therapies would require a better understanding of A(2B) receptor functions in diverse types of inflammatory responses in various tissues and at different points of their progression.
authors.affiliation: Department of Medicine, Vanderbilt University, Division of Cardiovascular Medicine, Nashville, Tennessee, USA.
authors.forename: Igor
authors.initials: I
authors.lastname: Feoktistov
authors.forename: Italo
authors.initials: I
authors.lastname: Biaggioni
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000166:cytology; D007249:Inflammation / Q000378:metabolism*; D043704:Receptor, Adenosine A2B / Q000378:metabolism*
chemical_list: D043704:Receptor, Adenosine A2B