title: (R)-4-[2-(Methyl-sulfanyl)pyrimidin-4-yl]-1-(tetra-hydro-furan-3-yl)-1H-pyrazol-5-amine.
abstract: The title compound, C(12)H(15)N(5)OS, was obtained by reaction of 2-(2-(methyl-thio)pyrimidin-4-yl)-3-oxopropane-nitrile with (tetra-hydro-furan-3-yl)hydrazine dihydro-chloride, and the racemic product was subsequently separated by chiral chromatography (first peak; [α](D) (20) = +51.3°). The chiral center at the substituted atom of the tetra-hydro-furanyl group has an R-configuration. The pyrimidine and pyrazolyl rings are almost coplanar, their mean planes forming a dihedral angle of 6.4 (1)°. One of the H atoms of the amino group participates in an intra-molecular hydrogen bond with the pyrimidine N atom in position 3. The second H atom is involved in an inter-molecular hydrogen bond, which links the mol-ecules into an infinite chain.
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Liu
authors.forename: Kevin K-C
authors.initials: KK
authors.lastname: Liu
authors.forename: Jeff
authors.initials: J
authors.lastname: Elleraas
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Rheingold
authors.forename: Antonio
authors.initials: A
authors.lastname: Dipasquale
authors.forename: Alex
authors.initials: A
authors.lastname: Yanovsky