title: Gender and age differences in candidates for radiofrequency catheter ablation of idiopathic ventricular arrhythmias.
abstract: BACKGROUND
  The prevalence, gender- and age-related differences, ablation success rate and inter-relationship between the origins of the idiopathic ventricular arrhythmias (I-VA) have not been clarified.
  
  
  RESULTS
  A total of 625 consecutive patients with symptomatic, drug resistant I-VA (315 males and 310 females; mean age, 54 ± 17 years; 218 ventricular tachycardias, 407 premature ventricular contractions) who underwent catheter ablation were studied. The patients were divided into 5 groups based on the VA origin: (1) outflow tract (OT)-VA, consisting of right ventricular (RV) OT-VA and left ventricular (LV) OT-VA; (2) inflow tract (IT)-VA, consisting of tricuspid annulus (TA)-free wall (FW)-VA, IT-septum-VA, and mitral (MA)-FW-VA; (3) LV-inferoseptum-VA; (4) LV-other-VA; and (5) RV-other-VA. RVOT-VA in women were 1.5 times more frequent than in men, while LVOT-VA were more frequent in men. The prevalence of LVOT origin I-VA increased with age compared to that for the RVOT. The mean age of MA-FW-VA patients (62 ± 14 years) was higher than that of TA-FW-VA patients (51 ± 18 years; P = 0.03). The ablation success rate for RVOT-VA (88%) was higher than that for LVOT-VA (58%; P<0.0001). A multivariate analysis revealed that the patient age was one of the valuable predictors of a successful ablation (odds ratio=0.97; 95% confidence interval: 0.95-0.99; P=0.007).
  
  
  CONCLUSIONS
  Distinct gender and age differences were found in the incidence of I-VA according to their site of origin.
authors.affiliation: Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tada
authors.forename: Sachiko
authors.initials: S
authors.lastname: Ito
authors.forename: Shigeto
authors.initials: S
authors.lastname: Naito
authors.forename: Koji
authors.initials: K
authors.lastname: Higuchi
authors.forename: Koji
authors.initials: K
authors.lastname: Kumagai
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hachiya
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hirao
authors.forename: Shigeru
authors.initials: S
authors.lastname: Oshima
authors.forename: Koichi
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Aonuma
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Isobe
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D001145:Arrhythmias, Cardiac / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D017115:Catheter Ablation; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012727:Sex Characteristics; D012737:Sex Factors; D017180:Tachycardia, Ventricular / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology; D018879:Ventricular Premature Complexes / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D055815:Young Adult