title: A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 60405.
abstract: During the course of screening for translocase I inhibitors, the new liposidomycin-related compounds, A-90289 A and B, were isolated from a culture broth of Streptomyces sp. SANK 60405. The structural elucidations were carried out by NMR and high-resolution mass spectral analyses, and they were classified as members of the liponucleoside antibiotics group with a sulfate group at the C-2' position. A-90289 A and B inhibited bacterial translocase I with IC(50) values of 36.5 ng ml(-1) and 33.8 ng ml(-1), respectively.
authors.affiliation: Lead Discovery and Optimization Research Laboratories I, Daiichi Sankyo Co. Ltd, Tokyo, Japan. fujita.yoko.x8@daiichisankyo.co.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujita
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kizuka
authors.forename: Masanori
authors.initials: M
authors.lastname: Funabashi
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Tomio
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Nonaka
authors.forename: Toshio
authors.initials: T
authors.lastname: Takatsu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001381:Azepines / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013302:Streptomyces / Q000378:metabolism*; D017855:Transferases (Other Substituted Phosphate Groups) / Q000037:antagonists & inhibitors*; D014498:Uracil / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C548455:A 90289A; C548456:A 90289B; D000900:Anti-Bacterial Agents; D001381:Azepines; D014498:Uracil; D017855:Transferases (Other Substituted Phosphate Groups); C100130:phospho-N-acetylmuramoyl pentapeptide transferase