title: CCR4 contributes to the pathogenesis of experimental autoimmune encephalomyelitis by regulating inflammatory macrophage function.
abstract: Chemokines and their receptors play a critical role in orchestrating the immune response during experimental autoimmune encephalomyelitis (EAE). Expression of CCR4 and its ligand CCL22 has been observed in ongoing disease. Here we describe a role for CCR4 in EAE, illustrating delayed and decreased disease incidence in CCR4(-/-) mice corresponding with diminished CNS infiltrate. Peripheral T cell responses were unaltered in CCR4(-/-) mice; rather, disease reduction was related to reduced CD11b(+)Ly6C(hi) inflammatory macrophage (iMϕ) numbers and function. These results provide evidence that CCR4 regulates EAE development and further supports the involvement of CCR4 in iMϕ effector function.
authors.affiliation: Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
authors.forename: Eileen A
authors.initials: EA
authors.lastname: Forde
authors.forename: Rukiye-Nazan E
authors.initials: RN
authors.lastname: Dogan
authors.forename: William J
authors.initials: WJ
authors.lastname: Karpus
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D018836:Inflammation Mediators / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D054398:Receptors, CCR4 / Q000502:physiology*
chemical_list: C515355:Ccr4 protein, mouse; D018836:Inflammation Mediators; D054398:Receptors, CCR4