title: ACE I/D polymorphism in Polish patients with endometriosis.
abstract: OBJECTIVE
  To analyse I/D polymorphism of ACE gene in women with diagnosed endometriosis and to determine the correlation of the identified genotypes with the stage of the disease and its clinical picture.
  
  
  METHODS
  The analysis of ACE I/D gene polymorphism was performed in a group of 121 women with endometriosis and in the control group of 122 women. In the study group the stage of the disease, number of pathological foci, occurrence of chronic pain in pelvis minor and infertility were taken into consideration.
  
  
  RESULTS
  In the study group the following distribution was found of ACE gene genotypes: II-25.62%, ID-47.93%, DD--26.45%, whereas in the control group: II--35.25%, ID--41.80%, DD--22.95%. The comparison of the frequency of analysed genotypes and alleles between the study and control groups did not demonstrate statistically significant differences (p > 0.05). Similarly no correlation was found for these parameters when the four stages of the disease acc. to rAFS (p > 0.05) were compared. In the study group the frequency was compared of the analysed ACE gene genotypes and alleles in women with infertility (n = 59) and in fertile women (n = 62). The comparison of these parameters did not demonstrate statistically significant differences between the analysed groups (p > 0.05). The frequency of genotype II was 17.07%, ID--46.34% and DD--36.59% in women with endometriosis complaining of pain (n=41). In the group of women with endometriosis without pain the frequency of the investigated genotypes (II, ID, DD) was respectively: 26.53%, 59.18%, 14.29%. DD genotype and D allele were more frequent in patients with pain complaints (p < 0.05).
  
  
  CONCLUSIONS
  In analysed population no association was found of ACE I/D polymorphism and the prevalence of endometriosis, its stages or the number of disease foci. However the association of DD genotype and D allele with the occurrence of pain within pelvis minor in women with endometriosis was found.
authors.affiliation: Department of Biology and Medical Genetics, Medical University of Łódź, Poland. liliana.kowalczynska@gmail.com
authors.forename: Liliana J
authors.initials: LJ
authors.lastname: Kowalczyńska
authors.forename: Ferenc
authors.initials: F
authors.lastname: Tomasz
authors.forename: Michał
authors.initials: M
authors.lastname: Wojciechowski
authors.forename: Anna
authors.initials: A
authors.lastname: Mordalska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Pogoda
authors.forename: Andrzej
authors.initials: A
authors.lastname: Malinowski
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004715:Endometriosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A