title: [Relationship between XRCC3 gene polymorphisms and lung cancer].
abstract: OBJECTIVE
  To explore the relationship between XRCC3 and lung cancer after selecting tag SNPs from HapMap database and reconstructing haplotypes.
  
  
  METHODS
  Using case-control study design, smoking condition were surveyed by questionare. Peripheral blood of cases and saliva or buccal cell for controls were collected, and then their DNA were extracted. XRCC3 tagSNPs were genotyped by PCR-RFLP. TagSNPs were selected by Haploview, HWE and LD were checked by LDA. Best genetic model and relationship between tagSNPs and lung cancer were analysed by SPSS, and haplotype frequencies and effects were computed by THESIAS.
  
  
  RESULTS
  Carriers of rs861537 AG or AA genotype had a statistically significantly increased risk for lung cancer (OR = 1.48, 95% CI: 1.17-1.86). Carriers of rs1799794 per G allele had a statistically significantly decreased risk for lung cancer (OR = 0.83, 95% CI: 0.72-0.97); no significant association was observed between rs861539 and lung cancer. Smoke interacted with rs861537 polymorphism. Compared with CGG haplotype, carriers of CAA had a statistically significantly increased risk for lung cancer (OR = 1.32, 95% CI 1.11-1.57).
  
  
  CONCLUSIONS
  XRCC3 gene polymorphisms were associated with lung cancer.
authors.affiliation: School of Public Health, Fujian Medical University, Fuzhou 350004, China. athome1984@sina.com
authors.forename: Meng
authors.initials: M
authors.lastname: Huang
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.forename: Yuefeng
authors.initials: Y
authors.lastname: Qiu
authors.forename: Lihui
authors.initials: L
authors.lastname: Fan
authors.forename: Junlei
authors.initials: J
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Cai
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3