title: Circumvention of Cisplatin resistance in h-ras transformed-nih/3t3 cells by suppressor mutant of h-ras.
abstract: The expression of H-ras oncogene, it has been shown, induces cisplatin resistance in vitro. Using two types of flat revertants (R1, F32/F33) which lost the transformed phenotypes, we studied the mechanism of the cisplatin resistance. R1 cells, which expressed an activated c-H-ras oncogene, exhibited increased cisplatin resistance. Further, F32/F33 cell lines, which were suppressed the H-ras function by a suppressor mutant of H-ras, restored the cisplatin sensitivity. These results implicate that the cisplatin resistance was directly related to the expression of H-ras and can be circumvented by suppression of the H-ras functions.
authors.affiliation: HOKKAIDO UNIV,SCH MED,INST CANC,MOLEC GENET LAB,SAPPORO,HOKKAIDO 060,JAPAN.
authors.forename: N
authors.initials: N
authors.lastname: Shinohara
authors.forename: Y
authors.initials: Y
authors.lastname: Ogiso
authors.forename: N
authors.initials: N
authors.lastname: Kuzumaki
authors.forename: L
authors.initials: L
authors.lastname: Mullauer
authors.forename: M
authors.initials: M
authors.lastname: Katabami
authors.forename: M
authors.initials: M
authors.lastname: Togashi
authors.forename: T
authors.initials: T
authors.lastname: Koyanagi