title: Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy.
abstract: Photodynamic therapy (PDT) has emerged as an alternative and promising noninvasive treatment for cancer as well as non-cancer diseases, which involves the uptake of photosensitizers (PSs) by cancer cells followed by irradiation. The use of nanomaterials as carriers of PSs is a very promising approach to improve the development of PDT in clinical medicine. In this study, a novel folic acid-conjugated graphene oxide (GO) was strategically designed and prepared as targeting drug delivery system to achieve higher specificity. The second generation photosensitizer (PS) Chlorin e6 (Ce6) was effectively loaded into the system via hydrophobic interactions and π-π stacking. The nanocarriers can significantly increase the accumulation of Ce6 in tumor cells and lead to a remarkable photodynamic efficacy on MGC803 cells upon irradiation. These suggested that folic acid-conjugated GO loaded Ce6 had great potential as effective drug delivery system in targeting PDT.
authors.affiliation: National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Cheng
authors.initials: C
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.forename: Can
authors.initials: C
authors.lastname: Wang
authors.forename: Xiansong
authors.initials: X
authors.lastname: Wang
authors.forename: Chunlei
authors.initials: C
authors.lastname: Zhang
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Zhou
authors.forename: Shouwu
authors.initials: S
authors.lastname: Guo
authors.forename: Daxiang
authors.initials: D
authors.lastname: Cui