title: 2-Aminoimidazole, glycociamidine and 2-thiohydantoin-marine alkaloids as molecular inspirations for the development of lead structures.
abstract: This review provides a detailed account on the biological activities of structurally diverse secondary metabolites from marine sponges having 2-aminoimidazole, glycociamidine and/or 2-thiohydantoin ring functions. This review will complement two previous short reviews which did however not address the potential of these natural products for drug discovery. We will discuss the naturally occurring alkaloids and give an account on their structure activity relationships.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Kumar
authors.forename: Shahnawaz
authors.initials: S
authors.lastname: Khan
authors.forename: Prem M S
authors.initials: PM
authors.lastname: Chauhan
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000578:Amidines / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013867:Thiohydantoins / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000578:Amidines; D007093:Imidazoles; D013867:Thiohydantoins; C014973:2-aminoimidazole