title: Discovering Molecular Targets in Cancer with Multiscale Modeling.
abstract: Multiscale modeling is increasingly being recognized as a promising research area in computational cancer systems biology. Here, exemplified by two pioneering studies, we attempt to explain why and how such a multiscale approach paired with an innovative cross-scale analytical technique can be useful in identifying high-value molecular therapeutic targets. This novel, integrated approach has the potential to offer a more effective in silico framework for target discovery and represents an important technical step towards systems medicine.
authors.affiliation: Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Wang
authors.forename: Veronika
authors.initials: V
authors.lastname: Bordas
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Deisboeck