title: Expression of CD25(high) regulatory T cells and PD-1 in gastric infiltrating CD4(+) T lymphocytes in patients with Helicobacter pylori infection.
abstract: We observed by flow cytometry that the frequency of both gastric infiltrating Tregs and PD-1-positive CD4 T cells is correlated with the density of Helicobacter pylori, suggesting that cellular immunity against this pathogen is inhibited.
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, China Medical University and Hospital, No. 91 Hsueh-Shih Rd., Taichung 404, Taiwan. yyw@mail.cmu.edu.tw
authors.forename: Yi-Ying
authors.initials: YY
authors.lastname: Wu
authors.forename: Jiunn-Horng
authors.initials: JH
authors.lastname: Chen
authors.forename: Jung-Ta
authors.initials: JT
authors.lastname: Kao
authors.forename: Kuo-Ching
authors.initials: KC
authors.lastname: Liu
authors.forename: Chih-Ho
authors.initials: CH
authors.lastname: Lai
authors.forename: Yuan-Min
authors.initials: YM
authors.lastname: Wang
authors.forename: Chin-Tung
authors.initials: CT
authors.lastname: Hsieh
authors.forename: Jason T C
authors.initials: JT
authors.lastname: Tzen
authors.forename: Ping-Ning
authors.initials: PN
authors.lastname: Hsu
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D005434:Flow Cytometry; D016481:Helicobacter Infections / Q000276:immunology; D016480:Helicobacter pylori; D006801:Humans; D007111:Immunity, Cellular; D053645:Interleukin-2 Receptor alpha Subunit / Q000032:analysis*; D061026:Programmed Cell Death 1 Receptor / Q000032:analysis* / Q000276:immunology*; D013270:Stomach / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor