title: Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.
abstract: We found that CNS-directed expression of interferon-γ (IFN-γ) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.
authors.affiliation: Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.
authors.forename: Paramita
authors.initials: P
authors.lastname: Chakrabarty
authors.forename: Carolina
authors.initials: C
authors.lastname: Ceballos-Diaz
authors.forename: Wen-Lang
authors.initials: WL
authors.lastname: Lin
authors.forename: Amanda
authors.initials: A
authors.lastname: Beccard
authors.forename: Karen
authors.initials: K
authors.lastname: Jansen-West
authors.forename: Nikolaus R
authors.initials: NR
authors.lastname: McFarland
authors.forename: Christopher
authors.initials: C
authors.lastname: Janus
authors.forename: Dennis
authors.initials: D
authors.lastname: Dickson
authors.forename: Pritam
authors.initials: P
authors.lastname: Das
authors.forename: Todd E
authors.initials: TE
authors.lastname: Golde
mesh_terms: D000367:Age Factors; D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism / Q000473:pathology*; D001480:Basal Ganglia Diseases / Q000378:metabolism / Q000473:pathology; D002114:Calcinosis / Q000378:metabolism*; D004195:Disease Models, Animal; D007371:Interferon-gamma / Q000378:metabolism*; D051379:Mice; D009410:Nerve Degeneration / Q000378:metabolism*; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology*
chemical_list: D007371:Interferon-gamma