title: Anthocyanin extract from black rice significantly ameliorates platelet hyperactivity and hypertriglyceridemia in dyslipidemic rats induced by high fat diets.
abstract: Our previous studies have demonstrated that anthocyanin extract from black rice (AEBR) inhibits atherosclerosis. Whether dietary AEBR supplementation can affect platelet function, an important factor in the pathogenesis of cardiovascular diseases, remains unclear. The aim of the present study is to explore the effects and mechanisms of dietary AEBR supplementation on platelet function and lipid profile in dyslipidemic rats. We demonstrated herein that thromboxane A(2), the thrombogenic ratio of thromboxane A₂ and prostacyclin, serum calmodulin, and soluble P-selectin were significantly decreased in rats fed a high fat diet supplemented with AEBR. AEBR supplementation also remarkably lowered serum triglyceride and raised hepatic CPT-1 mRNA expression. These findings suggest that dietary intake of AEBR reduces platelet hyperactivity, hypertriglyceridemia, and body weight gain, and facilitates in the maintenance of optimal platelet function in dyslipidemic rats induced by high fat diets.
authors.affiliation: Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, People's Republic of China. yangyan3@mail.sysu.edu.cn
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Marc C
authors.initials: MC
authors.lastname: Andrews
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
authors.forename: Dongliang
authors.initials: D
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Qin
authors.forename: Yanna
authors.initials: Y
authors.lastname: Zhu
authors.forename: Heyu
authors.initials: H
authors.lastname: Ni
authors.forename: Wenhua
authors.initials: W
authors.lastname: Ling
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage*; D001792:Blood Platelets / Q000187:drug effects*; D004041:Dietary Fats / Q000009:adverse effects*; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D050171:Dyslipidemias / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D012275:Oryza / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000872:Anthocyanins; D004041:Dietary Fats; D010936:Plant Extracts