title: Impact of routine percutaneous coronary intervention after out-of-hospital cardiac arrest due to ventricular fibrillation.
abstract: BACKGROUND
  Since 2003, we have routinely used percutaneous coronary intervention (PCI) and mild therapeutic hypothermia (MTH) to treat patients < 80 years of age after out-of-hospital cardiac arrest (OHCA) related to ventricular fibrillation. The aim of our study was to evaluate the prognostic impact of routine PCI in association with MTH and the potential influence of age.
  
  
  METHODS
  We studied 111 consecutive patients resuscitated successfully following OHCA related to shock-sensitive rhythm. They were divided into five groups according to age: < 45 years (n = 22, group 1), 45 to 54 years (n = 27, group 2), 55 to 64 years (n = 22, group 3), 65 to 74 years (n = 23, group 4) and ≥75 years (n = 17, group 5). Emergency coronary angiography was performed in hemodynamically stable patients < 80 years old, regardless of the electrocardiogram pattern. MTH was targeted to a core temperature of 32°C to 34°C for 24 hours.
  
  
  RESULTS
  Most patients (73%) had coronary heart disease, although its incidence in group 1 was lower than in other groups (41% versus 81%; P = 0.01). In group 1, all patients but one underwent coronary angiography, and 33% of them underwent associated PCI. In group 5, only 53% of patients underwent a coronary angiography and 44% underwent PCI. Overall in-hospital survival was 54%, ranging between 52% and 64% in groups 1 to 4 and 24% in group 5. Time from collapse to return of spontaneous circulation was associated with mortality (odds ratio (OR) = 1.05 (25th to 75th percentile range, 1.03 to 1.08); P < 0.001), whereas PCI was associated with survival (OR = 0.30 (25th to 75th percentile range, 0.11 to 0.79); P = 0.01).
  
  
  CONCLUSIONS
  We suggest that routine coronary angiography with potentially associated PCI may favorably alter the prognosis of resuscitated patients with stable hemodynamics who are treated with MTH after OHCA related to ventricular fibrillation. Although age was not an independent cause of death, the clinical relevance of this therapeutic strategy remains to be determined in older people.
authors.affiliation: Cardiological Department, Section Thorax-Vascular diseases-Abdomen-Metabolism, University Hospital Ambroise Paré, 9 avenue Charles de Gaulle, Boulogne, France. pierrick.cronier@apr.aphp.fr
authors.forename: Pierrick
authors.initials: P
authors.lastname: Cronier
authors.forename: Philippe
authors.initials: P
authors.lastname: Vignon
authors.forename: Koceila
authors.initials: K
authors.lastname: Bouferrache
authors.forename: Philippe
authors.initials: P
authors.lastname: Aegerter
authors.forename: Cyril
authors.initials: C
authors.lastname: Charron
authors.forename: François
authors.initials: F
authors.lastname: Templier
authors.forename: Samuel
authors.initials: S
authors.lastname: Castro
authors.forename: Rami
authors.initials: R
authors.lastname: El Mahmoud
authors.forename: Cécile
authors.initials: C
authors.lastname: Lory
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pichon
authors.forename: Olivier
authors.initials: O
authors.lastname: Dubourg
authors.forename: Antoine
authors.initials: A
authors.lastname: Vieillard-Baron
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D017023:Coronary Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000209:etiology / Q000628:therapy*; D011379:Prognosis; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000150:complications*