title: Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan.
abstract: The aim of this study was to develop and characterize the bioadhesive properties of poly(anhydride) nanoparticles coated with two types of low-molecular weight chitosan (CH20 of 20 kDa or CH50 of 50 kDa) or their thiolated conjugates. Nanoparticles were prepared by a solvent displacement method and characterized by measuring the size, zeta potential, morphology and composition. For bioadhesion studies, nanoparticles were fluorescently labelled with rhodamine B isothiocyanate. In all cases, coated nanoparticles showed a slightly higher size and lower negative zeta potential than uncoated nanoparticles. Nanoparticles coated with CH20 showed a higher adhesive capacity than uncoated nanoparticles. On the contrary, when nanoparticles were coated with CH50, the resulting carriers displayed a decreased ability to develop adhesive interactions within the gut. Finally, the coating of nanoparticles with thiolated chitosan improved their adhesive abilities. Poly(anhydride) nanoparticles coated with thiolated chitosan can be considered as promising bioadhesive particulate carriers for oral delivery strategies.
authors.affiliation: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. jmllabot@fcq.unc.edu.ar
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Llabot
authors.forename: Hesham
authors.initials: H
authors.lastname: Salman
authors.forename: Gioconda
authors.initials: G
authors.lastname: Millotti
authors.forename: Andreas
authors.initials: A
authors.lastname: Bernkop-Schnürch
authors.forename: Daniel
authors.initials: D
authors.lastname: Allemandi
authors.forename: Juan
authors.initials: J
authors.lastname: Manuel Irache
mesh_terms: D000269:Adhesives / Q000737:chemistry* / Q000627:therapeutic use; D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D007422:Intestines; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D049388:Polyanhydrides
chemical_list: D000269:Adhesives; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D049388:Polyanhydrides; D048271:Chitosan