title: Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.
abstract: Three novel 1-alkyldaphnane-type diterpenes, stelleralides A-C (4-6), and five known compounds were isolated from the roots of Stellera chamaejasme L. The structures of 4-6 were elucidated by extensive spectroscopic analyses. Several isolated compounds showed potent anti-HIV activity. Compound 4 showed extremely potent anti-HIV activity (EC(90) 0.40 nM) with the lowest cytotoxicity (IC(50) 4.3 μM) and appears to be a promising compound for development into anti-AIDS clinical trial candidates.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan. asaday@rs.noda.tus.ac.jp
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Asada
authors.forename: Aya
authors.initials: A
authors.lastname: Sukemori
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Kuber J
authors.initials: KJ
authors.lastname: Malla
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Kazuo
authors.initials: K
authors.lastname: Koike
authors.forename: Chin-Ho
authors.initials: CH
authors.lastname: Chen
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Akiyama
authors.forename: Keduo
authors.initials: K
authors.lastname: Qian
authors.forename: Kyoko
authors.initials: K
authors.lastname: Nakagawa-Goto
authors.forename: Susan L
authors.initials: SL
authors.lastname: Morris-Natschke
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D004224:Diterpenes; C560539:stelleralide A; C560540:stelleralide B; C560541:stelleralide C