title: Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe.
abstract: A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.
authors.affiliation: School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Jean-Louis H A
authors.initials: JL
authors.lastname: Duprey
authors.forename: Zheng-yun
authors.initials: ZY
authors.lastname: Zhao
authors.forename: Dario M
authors.initials: DM
authors.lastname: Bassani
authors.forename: Jack
authors.initials: J
authors.lastname: Manchester
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Vyle
authors.forename: James H R
authors.initials: JH
authors.lastname: Tucker
mesh_terms: D000873:Anthracenes / Q000737:chemistry; D002942:Circular Dichroism; D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D019175:DNA Methylation; D015342:DNA Probes / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D009693:Nucleic Acid Hybridization / Q000379:methods*; D013050:Spectrometry, Fluorescence
chemical_list: D000873:Anthracenes; D015342:DNA Probes; D005456:Fluorescent Dyes; D003596:Cytosine; D004247:DNA; C034020:anthracene