title: Study on drug property differences of shexiang (moschus) and bingpian (borneolum synthcticum) based on analysis of biothermodynamics.
abstract: OBJECTIVE
  To study the drug property differences of Shexiang (Moschus) and Bingpian (Borneolum Synthcticum) with biothermodynamics, and to verify the objectivity and authenticity of the drug property.
  
  
  METHODS
  The growth-thermogram curves of Escherichia coli (E. coli) affected by Shexiang (Moschus) and Bingpian (Borneolum Synthcticum) at different concentrations were determined with microcalorimetry, and the power-time curves (thermogram curves) of E. coli metabolism and characteristic parameters, such as growth rate constant (k), maximum output power (P(m)), peak time (t(p)), total heat-output (Q(t)), etc. were analyzed with the principal component analysis (PCA) to find the close correlative parameters, so as to objectively reflect the drug property differences of Shexiang (Moschus) and Bingpian (Borneolum Synthcticum).
  
  
  RESULTS
  The values of P2 in the second exponential growth phase increased with the increase of the concentrations of Shexiang (Moschus) and Bingpian (Borneolum Synthcticum), and the P2 of Shexiang (Moschus) was larger than that of Bingpian (Borneolum Synthcticum); Q2 increased with the increase of the concentrations of Shexiang (Moschus), but for Bingpian (Borneolum Synthcticum) it was opposite. It is indicated that they have different effects on P2 and Q2 of E. coli in the second exponential growth phase, and have differences in warm and cold natures.
  
  
  CONCLUSIONS
  The microcalorimetry can accurately and objectively appraise differences of the drug property of Shexiang (Moschus) and Bingpian (Borneolum Synthcticum) and verify the objectivity and authenticity of the drug property, so as to provide a new and useful method for studies of the drug property of Chinese drugs.
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610015, China.
authors.forename: Dan-Hong
authors.initials: DH
authors.lastname: Cheng
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Zeng
authors.forename: Hou-Lin
authors.initials: HL
authors.lastname: Xia
authors.forename: Yong
authors.initials: Y
authors.lastname: Fu
authors.forename: Dan
authors.initials: D
authors.lastname: Yan
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zhao
authors.forename: Xiao-He
authors.initials: XH
authors.lastname: Xiao
mesh_terms: D002151:Calorimetry / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D013816:Thermodynamics
chemical_list: D004365:Drugs, Chinese Herbal