title: In vivo volumetric imaging of chicken retina with ultrahigh-resolution spectral domain optical coherence tomography.
abstract: The chicken retina is an established animal model for myopia and light-associated growth studies. It has a unique morphology: it is afoveate and avascular; oxygen and nutrition to the inner retina is delivered by a vascular tissue (pecten) that protrudes into the vitreous. Here we present, to the best of our knowledge, the first in vivo, volumetric high-resolution images of the chicken retina. Images were acquired with an ultrahigh-resolution optical coherence tomography (UHROCT) system with 3.5 µm axial resolution in the retina, at the rate of 47,000 A-scans/s. Spatial variations in the thickness of the nerve fiber and ganglion cell layers were mapped by segmenting and measuring the layer thickness with a semi-automatic segmentation algorithm. Volumetric visualization of the morphology and morphometric analysis of the chicken retina could aid significantly studies with chicken retinal models of ophthalmic diseases.
authors.forename: Alireza Akhlagh
authors.initials: AA
authors.lastname: Moayed
authors.forename: Sepideh
authors.initials: S
authors.lastname: Hariri
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Song
authors.forename: Vivian
authors.initials: V
authors.lastname: Choh
authors.forename: Kostadinka
authors.initials: K
authors.lastname: Bizheva