title: Reverse cholesterol transport revisited: contribution of biliary versus intestinal cholesterol excretion.
abstract: Reverse cholesterol transport (RCT) is usually defined as high-density lipoprotein-mediated transport of excess cholesterol from peripheral tissues, including cholesterol-laden macrophages in vessel walls, to the liver. From the liver, cholesterol can then be removed from the body via secretion into the bile for eventual disposal via the feces. According to this paradigm, high plasma high-density lipoprotein levels accelerate RCT and hence are atheroprotective. New insights in individual steps of the RCT pathway, in part derived from innovative mouse models, indicate that the classical concept of RCT may require modification.
authors.affiliation: Department of Pediatrics, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: Gemma
authors.initials: G
authors.lastname: Brufau
authors.forename: Albert K
authors.initials: AK
authors.lastname: Groen
authors.forename: Folkert
authors.initials: F
authors.lastname: Kuipers
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D016632:Apolipoprotein A-I / Q000378:metabolism; D001659:Biliary Tract / Q000378:metabolism; D001693:Biological Transport, Active; D018955:CD36 Antigens / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D051379:Mice; D008954:Models, Biological
chemical_list: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D016632:Apolipoprotein A-I; D018955:CD36 Antigens; D008075:Lipoproteins, HDL; D002784:Cholesterol