title: [Association between aggressive behaviors and COMT Val158Met and 5-HTTLPR polymorphisms in children].
abstract: OBJECTIVE
  To investigate the association between aggressive behaviors and catechol-O-methyltransferase (COMT) single nucleotide polymorphism at position 158 from a valine to a methionine (Val158Met) as well as serotonin (5-HT) transporter gene linked polymorphic region (5-HTTLPR) in children.
  
  
  METHODS
  A total of 68 children who were exposed to domestic violence were recruited. The frequencies of genotypes and alleles of COMT Val158Met and 5-HTTLPR were examined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques. A comparison was conducted between 24 children with high scores of aggressive problems and 44 control children with low scores of aggressive problems according to Child Behavior Checklist (for parents).ResultsThere were no significant differences in genotypes of COMT Val158Met (χ2=1.612, P=0.447) and 5-HTTLPR (χ2=1.807, P=0.405) between the two groups. There were also no significant differences in the frequencies of alleles of COMT Val158Met (χ2=1.648, P=0.119) and 5-HTTLPR(χ2=0.403, P=0.527) in the two groups.
  
  
  CONCLUSIONS
  COMT Val158Met and 5-HTTLPR might not be the susceptible genes of children's aggression, suggesting that children's aggressive behaviors might be affected by multivariate factors.
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Cao
authors.forename: Long-Fei
authors.initials: LF
authors.lastname: Li
authors.forename: Xing-Fu
authors.initials: XF
authors.lastname: Zhao
authors.forename: Ya-Lin
authors.initials: YL
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000374:Aggression; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D002394:Catechol O-Methyltransferase