title: Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
abstract: We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10(-31) and P = 1.3 × 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.
authors.affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. nokato@ri.ncgm.go.jp
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kato
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Takeuchi
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.forename: Tanika N
authors.initials: TN
authors.lastname: Kelly
authors.forename: Min Jin
authors.initials: MJ
authors.lastname: Go
authors.forename: Xueling
authors.initials: X
authors.lastname: Sim
authors.forename: Wan Ting
authors.initials: WT
authors.lastname: Tay
authors.forename: Chien-Hsiun
authors.initials: CH
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Katsuya
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Yokota
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Rick Twee Hee
authors.initials: RT
authors.lastname: Ong
authors.forename: Toru
authors.initials: T
authors.lastname: Nabika
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Chang
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kokubo
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Keizo
authors.initials: K
authors.lastname: Ohnaka
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yamori
authors.forename: Eitaro
authors.initials: E
authors.lastname: Nakashima
authors.forename: Cashell E
authors.initials: CE
authors.lastname: Jaquish
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Mark
authors.initials: M
authors.lastname: Seielstad
authors.forename: Masato
authors.initials: M
authors.lastname: Isono
authors.forename: James E
authors.initials: JE
authors.lastname: Hixson
authors.forename: Yuan-Tsong
authors.initials: YT
authors.lastname: Chen
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
authors.forename: Xueya
authors.initials: X
authors.lastname: Zhou
authors.forename: Takao
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Jae-Pil
authors.initials: JP
authors.lastname: Jeon
authors.forename: Jian Jun
authors.initials: JJ
authors.lastname: Liu
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
authors.forename: Yun Ju
authors.initials: YJ
authors.lastname: Sung
authors.forename: Xuegong
authors.initials: X
authors.lastname: Zhang
authors.forename: Tien Yin
authors.initials: TY
authors.lastname: Wong
authors.forename: Bok-Ghee
authors.initials: BG
authors.lastname: Han
authors.forename: Shotai
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Toshio
authors.initials: T
authors.lastname: Ogihara
authors.forename: Dingliang
authors.initials: D
authors.lastname: Zhu
authors.forename: Naoharu
authors.initials: N
authors.lastname: Iwai
authors.forename: Jer-Yuarn
authors.initials: JY
authors.lastname: Wu
authors.forename: Yik Ying
authors.initials: YY
authors.lastname: Teo
authors.forename: E Shyong
authors.initials: ES
authors.lastname: Tai
authors.forename: Yoon Shin
authors.initials: YS
authors.lastname: Cho
authors.forename: Jiang
authors.initials: J
authors.lastname: He
mesh_terms: D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D003971:Diastole / Q000235:genetics; D005202:Asia, Eastern; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D013599:Systole / Q000235:genetics; D044465:White People / Q000235:genetics