title: [Effect of inhaled corticosteroids on bone mineral density in asthmatic adults: a 20 cases study].
abstract: BACKGROUND
  Inhaled corticosteroids are widely used in the treatment of asthma but their safety on bone density is controversial.
  
  
  OBJECTIVE
  To study in a population of adults with asthma receiving inhaled corticosteroids for long term, the effect of this therapy on bone mineral density.
  
  
  METHODS
  Prospective study including 20 asthmatics, aged from 20 to 45 years, treated with inhaled corticosteroids for 12 months or more, with no risk factors for osteoporosis. We compared osteodensitometric parameters in our patients, bone mass and T-score at vertebral and femoral witness to a population matched by age and sex.
  
  
  RESULTS
  The average age of our patients was 35.45 ± 5.43 years and the average BMI was 30.03 ± 5.77 kg/m2. The average daily dose of corticosteroid was 925 ± 133.27g of equivalent of beclometasone with an average take of 33.5 ± 21.3 months. The vertebral site bone mass average was 1216 ± 0106 g/cm2 in the studied group and 1201 ± 0099 g/cm2 in the control group without significant difference (p = 0380). At femur, the bone mass average was 1037 ± 0143 g/cm2 in the patient group and 1056 ± 0107 g/cm2 in the control group (p = 0380). We did not find a significant link between bone mineral density and cumulative dose or the duration of taking inhaled corticosteroids, BMI and tobacco.
  
  
  CONCLUSIONS
  Our work confirms like other previous studies the safety of inhaled corticosteroids on bone mineral density.
authors.affiliation: Hopital La Rabta, Tunis, Tunisie.
authors.forename: Kaouther Saadallaoui
authors.initials: KS
authors.lastname: Ben Hamida
authors.forename: Nadia
authors.initials: N
authors.lastname: Fajraoui Krichene
authors.forename: Khedija
authors.initials: K
authors.lastname: Ben Ghars Amara
authors.forename: Rim
authors.initials: R
authors.lastname: Haouachi
authors.forename: Hela
authors.initials: H
authors.lastname: Sahli
authors.forename: Slaheddine
authors.initials: S
authors.lastname: Sellami
authors.forename: Mohamed Ridha
authors.initials: MR
authors.lastname: Charfi
authors.forename: Bechir
authors.initials: B
authors.lastname: Zouari
mesh_terms: D015502:Absorptiometry, Photon; D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D015519:Bone Density / Q000187:drug effects*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones