title: Melioidosis: a clinical overview.
abstract: BACKGROUND
  Melioidosis, an infection caused by the environmental Gram-negative bacillus Burkholderia pseudomallei, has emerged as an important cause of morbidity and mortality in Southeast Asia and northern Australia.
  
  
  METHODS
  a review of the literature using PubMed.
  
  
  RESULTS
  Approaches to diagnosis and antimicrobial therapy.
  
  
  RESULTS
  Whether seroconversion signals the presence of a quiescent bacterial focus and an increase in long-term risk of melioidosis.
  
  
  CONCLUSIONS
  Melioidosis is potentially preventable, but there is a striking lack of evidence on which to base an effective prevention programme. An accurate map defining the global distribution of B. pseudomallei is needed, together with studies on the relative importance of different routes of infection. There is a marked difference in mortality from melioidosis in high-income versus lower income countries, and affordable strategies that reduce death from severe sepsis (from any cause) in resource-restricted settings are needed.
authors.affiliation: Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Direk
authors.initials: D
authors.lastname: Limmathurotsakul
authors.forename: Sharon J
authors.initials: SJ
authors.lastname: Peacock
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001210:Asia, Southeastern / Q000453:epidemiology; D001315:Australia / Q000453:epidemiology; D016957:Burkholderia pseudomallei / Q000276:immunology / Q000302:isolation & purification; D015780:Carbapenems / Q000008:administration & dosage; D002442:Ceftazidime / Q000008:administration & dosage; D003140:Communicable Disease Control; D004197:Disease Reservoirs / Q000382:microbiology*; D014943:Global Health; D006801:Humans; D008554:Melioidosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D012008:Recurrence; D018570:Risk Assessment; D018805:Sepsis / Q000209:etiology / Q000401:mortality; D016036:Seroepidemiologic Studies; D012698:Serologic Tests
chemical_list: D000890:Anti-Infective Agents; D015780:Carbapenems; D002442:Ceftazidime