title: Experimental antithrombotic effects of sesame seed whole grains and extracts.
abstract: Prevention of arterial thrombotic diseases has a high priority in developed countries. An inappropriate diet is known to enhance the risks for acute thrombotic events, and nutritional products experimentally shown to be antithrombotic, might contribute beneficial effects. The present study forms part of a series of investigations into the antithrombotic effect of various foods and vegetables. Roasted and crushed whole grains from six varieties of sesame seeds were added to the diet of mice. Antithrombotic activity was measured in the carotid artery in vivo, using a He-Ne laser-induced thrombosis technique after 12 weeks. Col/Chichibu/Maruteru-2/1995 and T016 varieties showed significant antithrombotic activity, whilst 00037803 was prothrombotic. The acute effects of purified ingredients, sesamin, sesamolin and sesamol, given orally or intra-arterially, were also examined after a single dose. The most effective ingredient was sesamol, followed by sesamolin and sesamin. Daily intake of specific antithrombotic sesame whole grains or purified active ingredients might help to prevent atherothrombotic diseases.
authors.affiliation: Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Nishi-ku, Kobe, Japan.
authors.forename: Chifumi
authors.initials: C
authors.lastname: Kinugasa
authors.forename: Aki
authors.initials: A
authors.lastname: Naemura
authors.forename: Kanae
authors.initials: K
authors.lastname: Hyodo
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nakai
authors.forename: Masumi
authors.initials: M
authors.lastname: Katsuta
authors.forename: Junichiro
authors.initials: J
authors.lastname: Yamamoto
mesh_terms: D000284:Administration, Oral; D000818:Animals; D052117:Benzodioxoles / Q000494:pharmacology; D059305:Diet, High-Fat; D004149:Dioxoles / Q000494:pharmacology; D004195:Disease Models, Animal; D002523:Edible Grain / Q000737:chemistry; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007261:Infusions, Intra-Arterial; D007834:Lasers; D017705:Lignans / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010636:Phenols / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D031685:Sesamum / Q000737:chemistry*; D013927:Thrombosis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*
chemical_list: D052117:Benzodioxoles; D004149:Dioxoles; D005343:Fibrinolytic Agents; D017705:Lignans; D010636:Phenols; D010936:Plant Extracts; C054124:sesamolin; C025583:sesamol; C054125:sesamin