title: Metabolomics: the chemistry between ecology and genetics.
abstract: Metabolomics is a fast developing field of comprehensive untargeted chemical analyses. It has many applications and can in principle be used on any organism without prior knowledge of the metabolome or genome. The amount of functional information that is acquired with metabolomics largely depends on whether a metabolome database has been developed for the focal species. Metabolomics is a level downstream from transcriptomics and proteomics and has been widely advertised as a functional genomics and systems biology tool. Indeed, it has been successfully applied to link phenotypes to genotypes in the model plant Arabidopsis thaliana. Metabolomics is also increasingly being used in ecology (ecological metabolomics) and environmental sciences (environmental metabolomics). In ecology, the technique has led to novel insights into the mechanisms of plant resistance to herbivores. Some of the most commonly used analytical metabolomic platforms are briefly discussed in this review, as well as their limitations. We will mainly focus on the application of metabolomics in plant ecology and genetics.
authors.affiliation: Department of Terrestrial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Boterhoeksestraat 48, NL-6666 GA Heteren, The Netherlands Laboratory of Plant Physiology, Wageningen University, Droevendaalsesteeg 1, NL-6708 PB Wageningen, The Netherlands Laboratory of Genetics, Wageningen University, Droevendaalsesteeg 1, NL-6708 PB Wageningen, The Netherlands Centre for Biosystems Genomics, Droevendaalsesteeg 1, NL-6708 PB Wageningen, The Netherlands.
authors.forename: Mirka
authors.initials: M
authors.lastname: Macel
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Van Dam
authors.forename: Joost J B
authors.initials: JJ
authors.lastname: Keurentjes