title: Linking specification to differentiation: From proneural genes to the regulation of ciliogenesis.
abstract: Much of developmental biology is concerned with the processes by which cells become committed to particular fates in a regulated fashion, whereas cell biology addresses, among other things, the variety of differentiated forms and functions that cells can acquire. One open question is how the regulators of the former process lead to attainment of the latter. 'High-level' regulators of cell fate specification include the proneural factors, which drive cells to commit as precursors in the sensory nervous system. Recent research has concentrated on the gene expression events downstream of proneural factor function. Here we summarise this research and describe our own research that has provided clear links between a proneural factor, atonal, and the cell biological programme of ciliogenesis, which is a central aspect of sensory neuron differentiation.
authors.affiliation: Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, UK
authors.forename: Petra I
authors.initials: PI
authors.lastname: zur Lage
authors.forename: T Ian
authors.initials: TI
authors.lastname: Simpson
authors.forename: Andrew
authors.initials: A
authors.lastname: Jarman
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism / Q000502:physiology*; D002454:Cell Differentiation; D002923:Cilia / Q000235:genetics / Q000378:metabolism; D004330:Drosophila / Q000166:cytology* / Q000235:genetics; D029721:Drosophila Proteins; D008957:Models, Genetic; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology*; D011984:Sensory Receptor Cells / Q000166:cytology; D059467:Transcriptome
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; C082142:ato protein, Drosophila