title: Human breast-carcinoma cells show correlation in expression of C-myc oncogene and the C-myc binding-protein (mbp-1).
abstract: The c-myc proto-oncogene is an early response gene which plays an important role in regulation of cell proliferation, differentiation and cell cycle control. Amplification and/or overexpression of this gene occurs in human breast carcinoma eels. The human c-myc promoter binding protein (MBP-1) is a negative regulatory factor for c-myc transcription, which binds to the upstream region of the c-myc P2 promoter. It was cloned and characterized from human cervical carcinoma cells. Normal human tissues and human breast carcinoma cells showed an elevated level of both MBP-1 and c-myc gene expression. In estrogen receptor (ER)-negative cells, the level of MBP-1 expression was higher than that of ER-positive cells. These results suggested a correlation between estrogen receptor status and the MBP-1 mRNA level.
authors.affiliation: ST LOUIS UNIV,DEPT INTERNAL MED,ST LOUIS,MO 63110. UNIV MARYLAND,CTR CANC,DEPT MED,BALTIMORE,MD 21201. UNIV ALABAMA,DEPT INTERNAL MED,BIRMINGHAM,AL 35294. UNIV ALABAMA,DEPT BIOCHEM,BIRMINGHAM,AL 35294.
authors.forename: R
authors.initials: R
authors.lastname: Ray
authors.forename: S
authors.initials: S
authors.lastname: Sheikh
authors.forename: J
authors.initials: J
authors.lastname: Fontana
authors.forename: D
authors.initials: D
authors.lastname: Miller