title: New strategies for medical management of castration-resistant prostate cancer.
abstract: Although advanced prostate cancer patients respond very well to front-line androgen deprivation, failure to hormonal therapy most often occurs after a median time of 18-24 months. The care of castration-resistant prostate cancer (CRPC) has significantly evolved over the past decade, with the onset of first-line therapy with docetaxel. Although numerous therapy schedules have been investigated alongside docetaxel, in either first-line or salvage therapy, results were dismal. However, CRPC chemotherapy is currently evolving, with, on the one hand, new agents targeting androgen metabolism and, on the other hand, significant progress in chemotherapy drugs, particularly for second-line therapy. The aim of the present review is to describe the current treatments for CRPC chemotherapy alongside their challengers that might shortly become new standards. In this article, we discuss the most recent data from clinical trials to provide the reader with a comprehensive, state-of-the-art overview of CRPC chemotherapy and hormonal therapy.
authors.affiliation: Department of Hematology and Oncology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
authors.forename: Irène
authors.initials: I
authors.lastname: Asmane
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Céraline
authors.forename: Brigitte
authors.initials: B
authors.lastname: Duclos
authors.forename: Lynn
authors.initials: L
authors.lastname: Rob
authors.forename: Valère
authors.initials: V
authors.lastname: Litique
authors.forename: Philippe
authors.initials: P
authors.lastname: Barthélémy
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bergerat
authors.forename: Patrick
authors.initials: P
authors.lastname: Dufour
authors.forename: Jean-Emmanuel
authors.initials: JE
authors.lastname: Kurtz
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000077143:Docetaxel; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000378:metabolism; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism; D013254:Steroid 17-alpha-Hydroxylase / Q000037:antagonists & inhibitors; D043823:Taxoids / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D011944:Receptors, Androgen; D043823:Taxoids; D000077143:Docetaxel; D013254:Steroid 17-alpha-Hydroxylase