title: The association between renal function and tooth loss in Japanese community-dwelling postmenopausal women.
abstract: OBJECTIVE
  This study examined whether low renal function is associated with the number of remaining teeth among community-dwelling elderly Japanese.
  
  
  BACKGROUND
  Many elderly individuals display both low renal function and tooth loss.
  
  
  METHODS
  Subjects comprised 405 randomly selected women (55-74 years old). Serum cystatin C level was used to assess renal dysfunction. Multiple linear regression analysis was used to evaluate the relationship between number of remaining teeth and serum cystatin C level, with number of remaining teeth as the dependent variable. Six variables were selected as independent variables in the final model: serum cystatin C; age; mean clinical attachment level; serum cross-linked N-telopeptide of type I collagen level; body mass index and smoking habits.
  
  
  RESULTS
  Multiple linear regression analysis revealed a significant relationship between number of remaining teeth and serum cystatin C level. The beta value for serum cystatin C level for the number of remaining teeth was -0.11 (p = 0.018).
  
  
  CONCLUSIONS
  This study indicates a relationship between serum cystatin C level and number of remaining teeth, suggesting that low renal function could be associated with tooth loss.
authors.affiliation: Department of Oral Health Science, Division of Preventive Dentistry, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan. akihiro@dent.niigata-u.ac.jp
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoshihara
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hideo
authors.initials: H
authors.lastname: Miyazaki
mesh_terms: D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D024042:Collagen Type I / Q000097:blood; D055316:Cystatin C / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D057187:Independent Living; D007564:Japan; D007668:Kidney / Q000502:physiology*; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood; D017622:Periodontal Attachment Loss / Q000150:complications; D017698:Postmenopause / Q000502:physiology*; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications; D012907:Smoking; D016388:Tooth Loss / Q000150:complications*
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D055316:Cystatin C; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin