title: [Resistive training reduces inflammation in skeletal muscle and improves the peripheral insulin sensitivity in obese rats induced by hyperlipidic diet].
abstract: OBJECTIVE
  To determine if resistive exercise protocol can modulate Tnf-α, SOCS3 and glucose transporter GLUT4 genes expression in skeletal muscle, and peripheral insulin sensitivity in obese rats induced by hyperlipidic diet.
  
  
  METHODS
  Wistar obese rats induced by hyperlipidic diet were subjected a resistive exercise protocol as jump squat. Insulin sensitivity and mRNA content of Tnf-α, SOCS3 and GLUT4 were assayed and compared among the groups: obese sedentary (OS) and exercised (OE), control sedentary (CS) and exercised (CE).
  
  
  RESULTS
  The mRNA content of Tnf-α and SOCS3 has increased in skeletal muscle from OS and has decreased in OE group. The protein and GLUT4 mRNA contents were correlated but they did not change among the groups. Peripheral insulin sensitivity has increased in the OE compared to OS group.
  
  
  CONCLUSIONS
  The resistive exercise reverses the peripheral insulin resistance and the inflammatory state in skeletal muscle from diet-induced obese rats.
authors.affiliation: Departamento de Fisioterapia, Universidade Estadual Paulista Júlio de Mesquita Filho, Presidente Prudente, SP, Brasil.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Panveloski-Costa
authors.forename: Danilo Antônio Correa
authors.initials: DA
authors.lastname: Pinto Júnior
authors.forename: Bruna Brasil
authors.initials: BB
authors.lastname: Brandão
authors.forename: Rafael Junges
authors.initials: RJ
authors.lastname: Moreira
authors.forename: Ubiratan Fabres
authors.initials: UF
authors.lastname: Machado
authors.forename: Patrícia Monteiro
authors.initials: PM
authors.lastname: Seraphim
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D009220:Myositis / Q000378:metabolism* / Q000503:physiopathology; D009765:Obesity / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004041:Dietary Fats; D009124:Muscle Proteins