title: Transforming growth-factor-alpha and factor-beta(1) levels in plasma and effusions from patients with cancer or hematologic malignancies.
abstract: Transforming growth factors-alpha and -beta1 are thought to play a role in carcinogenesis. Using a sandwich linked immunosorbent assay, we have measured TGF-alpha and -beta1 levels in malignant human plasma and effusions. TGF-alpha and -beta1 plasma levels were not significantly different among normal volunteers, patients with solid tumors, and patients with hematologic malignancies (TGF-alpha, p=0.225; TGF-beta1, p=0.354). Statistically significant differences were also not found in levels between malignant and non-malignant effusions (TGF-alpha, p=0.327; TGF-beta1, p=0.095). However, a trend for the majority of elevated TGF-alpha or TGF-beta1 levels to be in malignant effusions warrants further studies with larger numbers of samples.
authors.affiliation: PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT MED,DIV MED ONCOL,HERSHEY,PA 17033. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT BIOSTAT,HERSHEY,PA 17033. TRITON DIAGNOST INC,ALAMEDA,CA 94501. BERLEX BIOSCI INC,ALAMEDA,CA 94501. CELTRIX LABS INC,PALO ALTO,CA 94303.
authors.forename: L
authors.initials: L
authors.lastname: Witters
authors.forename: H
authors.initials: H
authors.lastname: Almondhiry
authors.forename: Y
authors.initials: Y
authors.lastname: Matthews
authors.forename: R
authors.initials: R
authors.lastname: Walker
authors.forename: B
authors.initials: B
authors.lastname: Langton
authors.forename: J
authors.initials: J
authors.lastname: Dasch
authors.forename: A
authors.initials: A
authors.lastname: Lipton