title: Surgical management of an Irish cohort of BRCA-mutation carriers.
abstract: Little information is available regarding the management of BRCA-related breast cancer in Ireland. A cancer genetics programme was initiated in 1992 at our institution to provide counselling and expert management for those with cancers resulting from inherited predisposition. We examined a cohort of BRCA mutation-carriers treated at a single institution over 16 years. A total of 107 women from 57 families were found to be carriers of mutations in BRCA1/2. Bilateral salpingo-oophorectomy was the most common prophylactic surgery performed. Overall survival between BRCA-related and sporadic breast cancer was equivalent. This is the first publication on surgical management of BRCA-mutation carriers in Ireland. It is imperative that those considered likely to harbour a mutation are referred early to a dedicated clinic so that appropriate counselling, testing and subsequent management to reduce the risk of dying from cancer can be undertaken.
authors.affiliation: Department of Surgery, Trinity Centre for Health Sciences, St. James Hospital, Dublin 8, Ireland.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Carroll
authors.forename: Carmel
authors.initials: C
authors.lastname: Nolan
authors.forename: Roisin
authors.initials: R
authors.lastname: Clarke
authors.forename: Michael
authors.initials: M
authors.lastname: Farrell
authors.forename: Noreen
authors.initials: N
authors.lastname: Gleeson
authors.forename: Terry
authors.initials: T
authors.lastname: Boyle
authors.forename: Barbara
authors.initials: B
authors.lastname: Dunne
authors.forename: Peter A
authors.initials: PA
authors.lastname: Daly
authors.forename: M John
authors.initials: MJ
authors.lastname: Kennedy
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Connolly
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D015331:Cohort Studies; D005185:Fallopian Tube Neoplasms / Q000517:prevention & control / Q000601:surgery; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D006801:Humans; D007494:Ireland; D008875:Middle Aged; D009154:Mutation; D010051:Ovarian Neoplasms / Q000517:prevention & control / Q000601:surgery; D010052:Ovariectomy; D058994:Salpingectomy; D016019:Survival Analysis; D016896:Treatment Outcome; D044465:White People / Q000235:genetics