title: Making space for anti-infective drug discovery.
abstract: The dwindling supply of effective treatments for infectious disease is cause for alarm. Searches for anti-infectives yielding fewer and fewer novel discoveries have been concentrated in overly restricted regions of target space, screening space, chemical space, and competition space. Appreciating the diverse axes of these spaces may encourage wider exploration.
authors.affiliation: Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA. cnathan@med.cornell.edu
authors.forename: Carl
authors.initials: C
authors.lastname: Nathan
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D003141:Communicable Diseases / Q000188:drug therapy*; D055808:Drug Discovery / Q000379:methods* / Q000639:trends*; D006801:Humans
chemical_list: D000890:Anti-Infective Agents