title: Ayurvedic genomics, constitutional psychology, and endocrinology: the missing connection.
abstract: A recent methodological approach for human classification, diagnosis, and therapeutics through the combination of current Western constitutional psychology somatotypes and traditional Indian medicine (prakriti) body types and mind (manas) is herein presented. The striking similarities between psychologic somatotypes and Indian medicine body types permits proposal of a finite genopsycho-somatotyping of humans. Genopsycho-somatotyping of humans consists of a set of common physiologic, physical, and psychologic attributes related to a common basic birth constitution that remains somewhat permanent during human lifetime, since it is proposed that this birth constitution is programmed in the person's DNA (genes). This mainly provides a tool for classifying the human population based on broad and finite phenotype clusters across different ethnicity, languages, geographical location, or self-reported ancestry. In spite of any social or environmental traumatic event, I propose for males that every basic constitution has an associated identification organ, a measured property or marker, a soma, and some psyche general tendencies suggesting specific behavior or recurrent conduct. Three (3) basic extreme genopsycho-somatotypes or birth constitutions are enunciated: mesomorphic or andrus (Pitta), endomorphic or thymus (Khapa), and ectomorphic or thyrus (Vata). The method further predicts that male andrus constitution across races shares similarities in androgen (An) nuclear receptor behavior, whereas thymus constitutions are mainly regulated by T-cells (Tc) nuclear receptor behavior. Moreover, it suggests that thyrus constitutions share similarities in thyroxine (Th) nuclear receptor behavior. These proposed nuclear receptors are expected to regulate the expression of specific genes, thereby controlling the embryonic development, adult homeostasis, and metabolism of the human organism in a very profound way. The method finally predicts small differences in measured property (An, Tc, and Th nuclear receptors behavior) within a birth constitution across different races to be expected by modulation effects in melanocyte-stimulating hormone receptor behavior.
authors.affiliation: Unit of Innovation in the Health and Life Sciences (IESV), Department of Physics and Geology, University of Pamplona, Pamplona, Norte de Santander, Colombia. rizzo.sierra.c.v@gmail.com
authors.forename: Carlos V
authors.initials: CV
authors.lastname: Rizzo-Sierra
mesh_terms: D001519:Behavior; D001824:Body Constitution / Q000235:genetics*; D004247:DNA; D005786:Gene Expression Regulation; D023281:Genomics; D005838:Genotype; D006728:Hormones / Q000502:physiology*; D006801:Humans; D008297:Male; D008515:Medicine, Ayurvedic; D010551:Personality / Q000145:classification / Q000235:genetics; D010641:Phenotype; D044469:Racial Groups; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D011979:Receptors, Pituitary Hormone / Q000502:physiology; D013008:Somatotypes / Q000235:genetics / Q000523:psychology; D013601:T-Lymphocytes / Q000502:physiology; D013974:Thyroxine / Q000502:physiology
chemical_list: D006728:Hormones; D018160:Receptors, Cytoplasmic and Nuclear; D011979:Receptors, Pituitary Hormone; C029446:MSH receptor; D004247:DNA; D013974:Thyroxine