title: [From kidney disease to ischemic heart disease].
abstract: Chronic kidney disease is a pathology progressively increasing in the world. Patients with renal disease have an about 20 times greater chance of dying for cardiovascular disease than to reach the stage of dialysis and, compared to general population, they have a three times greater risk of developing acute myocardial infarction. Based on these considerations, we analyzed the most important metabolic changes that occur in renal failure, predisposing to ischemic heart disease. Changes in lipids and calcium-phosphorus metabolism, inflammation and oxidative stress, hyperhomocysteinemia, renin-angiotensin-aldosterone axis, anemia, left ventricular hypertrophy and albuminuria have been considered.
authors.affiliation: Dipartimento di Clinica Medica e Nefrologia, Università degli Studi di Parma.
authors.forename: Elena
authors.initials: E
authors.lastname: Strada
authors.forename: Giorgio
authors.initials: G
authors.lastname: Savazzi
mesh_terms: D000419:Albuminuria / Q000503:physiopathology; D000740:Anemia / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D006801:Humans; D020138:Hyperhomocysteinemia / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D007249:Inflammation / Q000503:physiopathology; D007558:Italy / Q000453:epidemiology; D007674:Kidney Diseases / Q000150:complications; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D052439:Lipid Metabolism Disorders / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D018384:Oxidative Stress; D010758:Phosphorus / Q000378:metabolism; D015995:Prevalence; D012084:Renin-Angiotensin System; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D010758:Phosphorus; D002118:Calcium