title: Medical treatment in acute and long-term secondary prevention after transient ischaemic attack and ischaemic stroke.
abstract: Stroke is a major cause of death and disability worldwide. Without improvements in prevention, the burden will increase during the next 20 years because of the ageing population, especially in developing countries. Major advances have occurred in secondary prevention during the past three decades, which demonstrate the broader potential to prevent stroke. We review the main medical treatments that should be considered for most patients with transient ischaemic attack or ischaemic stroke in the acute phase and the long term, and draw attention to recent developments.
authors.affiliation: Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK. peter.rothwell@clneuro.ox.ac.uk
authors.forename: Peter M
authors.initials: PM
authors.lastname: Rothwell
authors.forename: Ale
authors.initials: A
authors.lastname: Algra
authors.forename: Pierre
authors.initials: P
authors.lastname: Amarenco
mesh_terms: D000208:Acute Disease; D000925:Anticoagulants / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications*; D002545:Brain Ischemia / Q000097:blood / Q000150:complications / Q000209:etiology; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002908:Chronic Disease; D003906:Developing Countries / Q000706:statistics & numerical data; D050171:Dyslipidemias / Q000097:blood / Q000150:complications / Q000188:drug therapy; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D002546:Ischemic Attack, Transient / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000209:etiology; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D055502:Secondary Prevention; D020521:Stroke / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control* / Q000628:therapy; D013997:Time Factors; D014218:Triage
chemical_list: D000925:Anticoagulants; D000959:Antihypertensive Agents; D002317:Cardiovascular Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005343:Fibrinolytic Agents; D000960:Hypolipidemic Agents