title: Transforming growth-factor-Beta (tgf-Beta) messenger-RNA expression and growth-control in human lung squamous carcinoma cell-lines.
abstract: The pattern of TGF-beta mRNA expression and response to TGF-beta isoforms has been examined in three lung squamous carcinoma cell lines (NX002, CX140 and CX143). Expression for TGF-beta1 and TGF-beta2 but not TGF-beta3 was found in all 3 lines. TGF-beta1 and TGF-beta3 (but not TGF-beta2) inhibited the growth of the NX002 cell line in culture. The effect of TGF-beta1 on growth was accompanied with changes in the cell cycle. These data indicate that the potential for autocrine regulation by TGF-beta is present in lung squamous carcinoma cells.
authors.affiliation: WESTERN GEN HOSP,ICRF MED ONCOL UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND.
authors.forename: J
authors.initials: J
authors.lastname: Bartlett
authors.forename: G
authors.initials: G
authors.lastname: Rabiasz
authors.forename: S
authors.initials: S
authors.lastname: Langdon
authors.forename: E
authors.initials: E
authors.lastname: Miller
authors.forename: W
authors.initials: W
authors.lastname: Miller