title: Clinical Evidence of the Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: A Phase II Study.
abstract: The aim of this study was to evidence the clinical efficacy of an alcohol-free mouthwash containing 5.0% (W/V) Brazilian green propolis (MGP 5%) for the control of plaque and gingivitis. Twenty five subjects, men and women aging between 18 and 60 years old (35 ± 9), were included in a clinical trials phase II study who had a minimum of 20 sound natural teeth, a mean plaque index of at least 1.5 (PI), and a mean gingival index of at least 1.0 (GI). They were instructed to rinse with 10 mL of mouthwash test for 1 minute, immediately after brushing in the morning and at night. After 45 and 90 days using mouthwash, the results showed a significant reduction in plaque and in gingival index when compared to samples obtained in baseline. These reductions were at 24% and 40%, respectively (P < .5). There were no important side effects in soft and hard tissues of the mouth. In this study, the MGP 5% showed evidence of its efficacy in reducing PI and GI. However, it is necessary to perform a clinical trial, double-blind, randomized to validate such effectiveness.
authors.affiliation: Laboratory of Microbiology and Biomaterials, Department of Oral Clinical, Oral Pathology, Oral Surgery, Faculty of Dentistry, Federal University of Minas Gerais, Campus Pampulha, Avenida Presidente Antônio Carlos 6627, 31.270-901 Belo Horizonte, MG, Brazil.
authors.forename: Elizete Maria Rita
authors.initials: EM
authors.lastname: Pereira
authors.forename: João Luís Duval Cândido
authors.initials: JL
authors.lastname: da Silva
authors.forename: Fernando Freitas
authors.initials: FF
authors.lastname: Silva
authors.forename: Mariana Passos
authors.initials: MP
authors.lastname: De Luca
authors.forename: Efigênia Ferreira E
authors.initials: EF
authors.lastname: Ferreira
authors.forename: Telma Campos Medeiros
authors.initials: TC
authors.lastname: Lorentz
authors.forename: Vagner Rodrigues
authors.initials: VR
authors.lastname: Santos