title: [Comparison of two different types of hormone therapy effects on haemostatic parameters in early postmenopausal women].
abstract: BACKGROUND
  Most postmenopausal women have some of menopausal symptoms due to oestrogen deprivation. Many therapeutic options are available for managing menopausal problems. However, hormone therapy is associated with a heightened risk for thromboembolic events.
  
  
  OBJECTIVE
  To investigate the effects of different types of hormone therapy on some haemostatic parameters.
  
  
  METHODS
  This randomized, controlled study included 56 healthy, early postmenopausal women aged 46-58 years on different types of hormone therapy (tibolone 2.5 mg/day, 25 women, or CCHT 2 mg estradiol plus 1 mg norethisteron acetate, 31 women) and 20 healthy postmenopausal women of the same age receiving placebo. Effects of these 2 medicaments on some haemostasis parameters were measured 3 and 6 months after the onset of treatment.
  
  
  RESULTS
  Short-term use (3 months) of both tibolone and CCHT had a detrimental effect on antithrombin, protein C and protein S levels (decreased), and even more so in the group treated with CCHT. Plasminogen-activator inhibitor type 1 levels were decreased by both tibolone and CCHT, but more so by CCHT; thrombin-antithrombin complex were increased in both groups. There were no changes in haemostatic parameters between 3-month and 6-month treatment in any group.
  
  
  CONCLUSIONS
  Both therapeutic options are associated with an activation of thrombogenic and fibrinolytic markers within 3 months of use. Tibolone appears to produce a better balance between thrombogenesis and fibrinolysis. Since our results show a lower incidence of thrombotic events, further studies are required.
authors.forename: Lidija
authors.initials: L
authors.lastname: Tasić
authors.forename: Radica
authors.initials: R
authors.lastname: Dunjić
authors.forename: Mladenko
authors.initials: M
authors.lastname: Vasiljević
authors.forename: Svetlana
authors.initials: S
authors.lastname: Dikić
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Jurisić
authors.forename: Dijana
authors.initials: D
authors.lastname: Tasić
mesh_terms: D004958:Estradiol / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009640:Norethindrone / Q000494:pharmacology*; D009652:Norpregnenes / Q000494:pharmacology*; D017698:Postmenopause / Q000097:blood*
chemical_list: D009652:Norpregnenes; D004958:Estradiol; C027385:tibolone; D009640:Norethindrone