title: Absence of association between GSTM1 and GSTT1 polymorphisms and melanoma susceptibility: a meta-analysis.
abstract: Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are involved in the metabolism of many xenobiotics, including a wide range of environmental carcinogens. The null genotypes GSTM1 and GSTT1 have been implicated in the development of carcinogenesis. We conducted a meta-analysis to examine the association of GSTM1 and GSTT1 homozygous deletion polymorphisms with melanoma risk. In total, 8 relevant studies were identified in searches of the PubMed and Embase databases: 8 investigated GSTM1 (1349 cases and 1560 controls) and 5 GSTT1 (977 cases and 1060 controls). Fixed- and random-effects models were used to assess the summary odds ratios (ORs). No significant association of the GSTM1 and GSTT1 polymorphisms or the GSTM1-GSTT1 interaction on the risk of melanoma was observed (for GSTM1: OR=1.09; 95% confidence interval, 0.94-1.27; and for GSTT1: OR=0.95; 95% confidence interval, 0.76-1.19). Similarly, no significant association was found in a subgroup analysis of hair color. These results indicate that the GSTM1 and GSTT1 polymorphisms may not be a risk factor for developing melanoma.
authors.affiliation: Department of Plastic Surgery, West China Hospital of Sichuan University, Chengdu, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Nie
authors.forename: Zhixing
authors.initials: Z
authors.lastname: Chen
authors.forename: Chang
authors.initials: C
authors.lastname: Cao
authors.forename: Ying
authors.initials: Y
authors.lastname: Cen
mesh_terms: D001315:Australia; D016022:Case-Control Studies; D002677:Chile; D016206:Databases, Bibliographic; D005060:Europe; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006200:Hair Color / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008545:Melanoma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D014481:United States
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1