title: Mitochondrial DNA variation in human metabolic rate and energy expenditure.
abstract: The role of climate in driving selection of mtDNA as Homo sapiens migrated out of Africa into Eurasia remains controversial. We evaluated the role of mtDNA variation in resting metabolic rate (RMR) and total energy expenditure (TEE) among 294 older, community-dwelling African and European American adults from the Health, Aging and Body Composition Study. Common African haplogroups L0, L2 and L3 had significantly lower RMRs than European haplogroups H, JT and UK with haplogroup L1 RMR being intermediate to these groups. This study links mitochondrial haplogroups with ancestry-associated differences in metabolic rate and energy expenditure.
authors.affiliation: California Pacific Medical Center Research Institute, San Francisco, CA, 94107, USA. gtranah@sfcc-cpmc.edu
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Tranah
authors.forename: Todd M
authors.initials: TM
authors.lastname: Manini
authors.forename: Kurt K
authors.initials: KK
authors.lastname: Lohman
authors.forename: Michael A
authors.initials: MA
authors.lastname: Nalls
authors.forename: Stephen
authors.initials: S
authors.lastname: Kritchevsky
authors.forename: Anne B
authors.initials: AB
authors.lastname: Newman
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.forename: Iva
authors.initials: I
authors.lastname: Miljkovic
authors.forename: Alessandro
authors.initials: A
authors.lastname: Biffi
authors.forename: Steven R
authors.initials: SR
authors.lastname: Cummings
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Liu
mesh_terms: D001741:Black or African American; D000368:Aged; D004272:DNA, Mitochondrial / Q000235:genetics* / Q000378:metabolism*; D004734:Energy Metabolism / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D008297:Male; D014481:United States; D044465:White People
chemical_list: D004272:DNA, Mitochondrial