title: Histone deacetylase inhibitors in the treatment of hematological malignancies.
abstract: Histone deacetylases (HDACs) play a central role in the epigenetic regulation of gene expression. Aberrant activity of HDACs has been found in several human cancers leading to the development of HDAC inhibitors (HDACi) as anti-tumors drugs. In fact, over the last years, a number of HDACi have been evaluated in clinical trials; these drugs have the common ability to hyperacetylate both histone and non-histone targets, resulting in a variety of effects on both cancer cells and immune responses. Clinical trials of HDACi conducted in solid tumors and hematological malignancies have shown a better clinical efficacy of these drugs in hematological malignancies. In this review, will be highlighted the mechanisms of action underlying the clinical responses obtained with these drugs and the doubts regarding the use of HDACi in cancer therapy.
authors.affiliation: Department Scienze Farmaceutiche e Biomediche Università di Salerno Via Ponte Don Melillo 84084 Fisciano, Salerno, Italy. apetrella@unisa.it
authors.forename: A
authors.initials: A
authors.lastname: Petrella
authors.forename: B
authors.initials: B
authors.lastname: Fontanella
authors.forename: A
authors.initials: A
authors.lastname: Carratù
authors.forename: V
authors.initials: V
authors.lastname: Bizzarro
authors.forename: M
authors.initials: M
authors.lastname: Rodriquez
authors.forename: L
authors.initials: L
authors.lastname: Parente
mesh_terms: D001549:Benzamides / Q000737:chemistry / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D006655:Histone Deacetylases / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry / Q000627:therapeutic use; D010456:Peptides, Cyclic / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D001549:Benzamides; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D010456:Peptides, Cyclic; D006655:Histone Deacetylases