title: Hexokinase: a novel sugar kinase coupled to renal epithelial cell survival.
abstract: Hexokinases have emerged as novel mediators of the antiapoptotic effects of growth factors in a wide variety of cells. These effects have been attributed to highly regulated direct physical and functional interactions with mitochondria. The demonstration that mitochondrial hexokinases can prevent apoptogenic 'Bax attack' in proximal tubule cells suggests a need to reexamine the specific contributions of hexokinases and glucose metabolism in this nephron segment and elsewhere within the kidney.
authors.affiliation: Veterans Affairs Medical Center, Vermont, USA. R.Brooks.Robey@Dartmouth.edu
authors.forename: R Brooks
authors.initials: RB
authors.lastname: Robey
mesh_terms: D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D004847:Epithelial Cells / Q000201:enzymology* / Q000473:pathology; D006593:Hexokinase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000201:enzymology* / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000098:blood supply / Q000201:enzymology* / Q000473:pathology; D051336:Mitochondrial Membranes / Q000201:enzymology* / Q000473:pathology; D021381:Protein Transport; D015427:Reperfusion Injury / Q000201:enzymology* / Q000473:pathology; D015398:Signal Transduction; D013312:Stress, Physiological; D051028:bcl-2-Associated X Protein / Q000378:metabolism
chemical_list: D051028:bcl-2-Associated X Protein; D006593:Hexokinase