title: Prognostic-significance of p53 mutations in small non-cleaved cell lymphomas.
abstract: We have assessed the prognostic significance of mutations in the p53 tumor suppressor gene in patients with small non-cleaved cell lymphomas. In this retrospective pilot study we have, been able to evaluate the response to therapy of 21 previously untreated patients. Seven of these patients (33%) had tumors which contained a p53 mutation at presentation. Five of the 7 patients with mutant p53 relapsed and 4 died of progressive disease whereas none of the patients with wild type p53 relapsed and none died of progressive disease. These preliminary results strongly suggest that the presence of a mutated p53 gene is an unfavorable prognostic factor. p53 mutations could be used as a parameter in risk-adapted therapy protocols, or could even provide an appropiate target for therapy.
authors.affiliation: NCI,PEDIAT BRANCH,LYMPHOMA BIOL SECT,BLDG 10,ROOM 13N240,BETHESDA,MD 20892. HOSP PEDIAT PROF DR JUAN P GARRAHAN,DEPT HEMATOL ONCOL,RA-1245 BUENOS AIRES,ARGENTINA. HOSP NINOS DR RICARDO GUTIERREZ,DEPT ONCOL,RA-1425 BUENOS AIRES,ARGENTINA. HOSP AC CARMARGO FUNDACAO ANTONIO PRUDENTE,BR-01509 SAO PAULO,BRAZIL. NCI,MOLEC GENET SECT,BETHESDA,MD 20892.
authors.forename: M
authors.initials: M
authors.lastname: Gutierrez
authors.forename: K
authors.initials: K
authors.lastname: Bhatia
authors.forename: B
authors.initials: B
authors.lastname: Diez
authors.forename: F
authors.initials: F
authors.lastname: Muriel
authors.forename: S
authors.initials: S
authors.lastname: Epelman
authors.forename: M
authors.initials: M
authors.lastname: Deandreas
authors.forename: K
authors.initials: K
authors.lastname: Huppi
authors.forename: I
authors.initials: I
authors.lastname: Magrath