title: Canine pancreatic clear acinar cell carcinoma showing an unusual mucinous differentiation.
abstract: A small solitary pancreatic nodule was identified in a 10-year-old mixed breed male dog. Microscopically, the lesion consisted of neoplastic clear acinar cells with diffuse, marked mucin production. Immunohistochemical and ultrastructural investigations confirmed the exocrine acinar origin of the tumour. The tumour was classified as a pancreatic clear acinar cell carcinoma (ACC) showing an unusual mucinous differentiation.
authors.affiliation: Department of Biopathological Science and Hygiene of Animal and Food Production, Faculty of Veterinary Medicine, University of Perugia, Perugia, Italy. pavone.silvia@libero.it
authors.forename: S
authors.initials: S
authors.lastname: Pavone
authors.forename: E
authors.initials: E
authors.lastname: Manuali
authors.forename: C
authors.initials: C
authors.lastname: Eleni
authors.forename: A
authors.initials: A
authors.lastname: Ferrari
authors.forename: E
authors.initials: E
authors.lastname: Bonanno
authors.forename: A
authors.initials: A
authors.lastname: Ciorba
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D018267:Carcinoma, Acinar Cell / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D002454:Cell Differentiation; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D008297:Male; D008854:Microscopy, Electron; D008940:Mitotic Index; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor