title: Investigations of genotoxic activity of antimicrobial/antiviral agent FS-1 in human lymphocytes and tumor cell.
abstract: A very promising antiviral and antimicrobial agent FS-1 was studied for its ability to induce DNA damage and micronuclei in human tumor cell lines HeLa and Caco-2 at concentrations of 200, 500 and 1000 microg/ml without exogenous metabolic activation. The compound was additionally tested for DNA damaging ability in human lymphocytes at concentrations of 200, 400 and 800 microg/ml. Neither DNA damage nor micronucleus formation was observed after treatment of all types of cells with FS-1. Based on these results, FS-1 can be further studied for its safety to humans for potential application in clinical medicine as an antimicrobial/antiviral drug.
authors.affiliation: National Center of Oncology, Yerevan, Armenia. armen.nersesyan@meduniwien.ac.at
authors.forename: A
authors.initials: A
authors.lastname: Nersesyan
authors.forename: A
authors.initials: A
authors.lastname: Ilin
authors.forename: M
authors.initials: M
authors.lastname: Kulmanov
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000633:toxicity; D000890:Anti-Infective Agents / Q000633:toxicity*; D000998:Antiviral Agents / Q000633:toxicity; D018938:Caco-2 Cells; D020552:Comet Assay; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006367:HeLa Cells; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents