title: Role of L-DOPA in spinal nociceptive reflex activity: higher sensitivity of Aδ versus C fibre-evoked nociceptive reflexes to L-DOPA.
abstract: The role of L-DOPA in spinal nociceptive reflex activity has been re-evaluated. In high spinal cats, with supraspinal loops being excluded, the onset of reflex facilitation induced by noxious radiant heat is delayed after injection of L-DOPA by 4 to 10 s, i.e. the early component of nociceptive reflex facilitation is blocked, while the late component persisted. Further investigations have shown that the early component of reflex facilitation induced by noxious radiant heat is mediated by Adelta-fibres and the late component by C-fibres. Therefore, it can be assumed that L-DOPA, like opioids, preferentially blocks the transmission in nociceptive reflex pathways from Adelta-fibres.
authors.affiliation: Institute of Physiology, University of Göttingen, Göttingen, Germany. eschomb@gwdg.de
authors.forename: E D
authors.initials: ED
authors.lastname: Schomburg
authors.forename: P
authors.initials: P
authors.lastname: Dibaj
authors.forename: H
authors.initials: H
authors.lastname: Steffens
mesh_terms: D000818:Animals; D002415:Cats; D007980:Levodopa / Q000494:pharmacology*; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000502:physiology*; D036421:Nerve Fibers, Unmyelinated / Q000187:drug effects / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*
chemical_list: D007980:Levodopa