title: [Synthesis of heptakis(2,3,6-tri-O-methoxymethyl)-beta-cyclodextrin and its application in gas chromatography].
abstract: A new chiral stationary phase for gas chromatography, heptakis (2, 3, 6-tri-O-methoxymethyl)-beta-cyclodextrin, was synthesized by substituting the 2,3,6-OH groups of beta-cyclodextrin with methoxymethyl groups, and a coated capillary column for gas chromatography was made by coating this new stationary phase with static method. The chromatographic properties and separation abilities of the prepared stationary phase were studied. The test results showed that it possessed good separation abilities to Grob test mixture, disubstituted benzene isomers (e. g. nitrotoluenes, bromotoluenes, dichlorobenzenes, dimethylbenzenes) and some chiral compounds such as methyl 2-hydroxypropionates, ethyl 2-hydroxypropionates, methyl 2-methylsulfonylpropionates. The comparison of chiral separation results between 2,3,6-tri-O-methoxymethyl-beta-cyclodextrin and 2,3,6-tri-O-methyl-beta-cyclodextrin showed that the separation abilities of the two stationary phases were different and complementary to each other for some chiral ester enantiomers.
authors.affiliation: Key Laboratory of Pesticide Chemistry and Application Technology of Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Yin
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhu
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Liu
authors.forename: Jiangchun
authors.initials: J
authors.lastname: Zhong
authors.forename: Fuliang
authors.initials: F
authors.lastname: Chen
mesh_terms: D002849:Chromatography, Gas / Q000379:methods*; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D047392:beta-Cyclodextrins; C000609658:heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin