title: Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanism.
abstract: Guarani et al. (2011), reporting in Nature, identify a mechanism for fine-tuning endothelial Notch signaling by SIRT1-mediated deacetylation. This regulation is critical for vascular sprouting and raises intriguing questions about therapeutic targeting of SIRT1 in angiogenesis and the potential mechanisms that link vascular growth and energy homeostasis.
authors.affiliation: Department of Ob/Gyn, Pathology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. jkk9@columbia.edu
authors.forename: Jan
authors.initials: J
authors.lastname: Kitajewski