title: Antimicrobial effect of adjunctive use of chlorhexidine mouthrinse in untreated gingivitis: a randomized, placebo-controlled study.
abstract: The aim of this study was to examine the effectiveness of chlorhexidine mouthrinse (CHX) in addition to daily plaque control on subgingival microbiota in patients with untreated gingivitis. Fifty gingivitis patients were randomized to CHX or placebo groups. CHX group rinsed with 0.2% CHX, while placebo group rinsed with placebo mouthrinse for 4 weeks. Subgingival plaque samples were collected and plaque index (PI), papilla bleeding index (PBI), calculus index, and probing pocket depth (PPD) were recorded at baseline and at 4 weeks. The amounts of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Fusobacterium nucleatum, and total bacteria were detected by quantitative real-time PCR method. In the CHX group the total bacteria count was significantly reduced in posterior teeth at 4 weeks (p < 0.05), while no significant decrease was observed in the placebo group (p > 0.05). CHX mouthrinse as an adjunct to daily plaque control could be useful in the management of plaque-associated gingivitis and in reducing the subgingival total bacteria count especially in posterior teeth.
authors.affiliation: Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey. semacinar@yahoo.com
authors.forename: Sema
authors.initials: S
authors.lastname: Becerik
authors.forename: Oya
authors.initials: O
authors.lastname: Türkoğlu
authors.forename: Gülnur
authors.initials: G
authors.lastname: Emingil
authors.forename: Caner
authors.initials: C
authors.lastname: Vural
authors.forename: Güven
authors.initials: G
authors.lastname: Ozdemir
authors.forename: Gül
authors.initials: G
authors.lastname: Atilla
mesh_terms: D000293:Adolescent; D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects / Q000254:growth & development; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D058491:Bacterial Load; D002710:Chlorhexidine / Q000627:therapeutic use*; D003773:Dental Plaque / Q000188:drug therapy; D003774:Dental Plaque Index; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D016966:Porphyromonas gingivalis / Q000187:drug effects / Q000254:growth & development; D018713:Prevotella intermedia / Q000187:drug effects / Q000254:growth & development; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D009067:Mouthwashes; D002710:Chlorhexidine