title: Ready synthesis of free N-H 2-arylindoles via the copper-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization.
abstract: A wide range of free N-H 2-arylindoles were synthesised via the copper(II)-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization. The convenience and atom economy of aqueous ammonia, and the low cost of the copper catalytic system make this protocol readily superior in practical application.
authors.affiliation: State Key Laboratory of Fine Chemicals, College of Chemical Engineering, Dalian University of Technology, Dalian, 116012, China.
authors.forename: Huifeng
authors.initials: H
authors.lastname: Wang
authors.forename: Yaming
authors.initials: Y
authors.lastname: Li
authors.forename: Linlin
authors.initials: L
authors.lastname: Jiang
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Jin
authors.forename: Defeng
authors.initials: D
authors.lastname: Zhao
authors.forename: Chunying
authors.initials: C
authors.lastname: Duan
mesh_terms: D000114:Acetylene / Q000737:chemistry*; D000586:Amination; D000641:Ammonia / Q000737:chemistry*; D017605:Bromine Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis*; D008024:Ligands; D015394:Molecular Structure
chemical_list: D017605:Bromine Compounds; D007211:Indoles; D008024:Ligands; D000641:Ammonia; D003300:Copper; D000114:Acetylene