title: Remarkable enantioselectivity of molecularly imprinted TiO2 nano-thin films.
abstract: TiO(2) nano-thin films with imprinted (R)- and (S)-enantiomers of propranolol, 1,1'-bi-naphthol, and 2-(4-isobutylphenyl)-propionic acid were fabricated on quartz plates by spin-coating their solutions with Ti(O-(n)Bu)(4) in a toluene-ethanol mixture (1:1, v/v). After template removal, the imprinted films showed better binding for original templates than to the corresponding enantiomers. The assessment of template incorporation, template removal, and re-binding was conducted through UV-vis measurements. Significant enhancement of enantioselectivity was achieved by optimization of the film thickness and by heat-treatment of the imprinted films. After subtraction of non-specific binding, the optimized films provided chiral recognition with the enantioselectivity of almost 100% for (R)-propranolol and 95% for (S)-propranolol.
authors.affiliation: Graduate School of Environmental Engineering, the University of Kitakyushu, 1-1 Hibikino, Kitakyushu, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Mizutani
authors.forename: Do-Hyeon
authors.initials: DH
authors.lastname: Yang
authors.forename: Roman
authors.initials: R
authors.lastname: Selyanchyn
authors.forename: Sergiy
authors.initials: S
authors.lastname: Korposh
authors.forename: Seung-Woo
authors.initials: SW
authors.lastname: Lee
authors.forename: Toyoki
authors.initials: T
authors.lastname: Kunitake
mesh_terms: D007052:Ibuprofen; D054802:Molecular Imprinting / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry*; D009284:Naphthols / Q000737:chemistry; D011422:Propionates / Q000737:chemistry; D011433:Propranolol / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D009284:Naphthols; D011422:Propionates; C009495:titanium dioxide; D011433:Propranolol; D014025:Titanium; D007052:Ibuprofen