title: Design, synthesis of novel quinazolone alkaloids derivatives as potential antitumor agents.
abstract: Several novel quinazolone alkaloids derivatives were synthesized. Some of the target compounds were determined against human prostate cancer DU145 and pancreatic cancer Miacapa2 cells in vitro. The entire compounds had been identified by ¹HNMR, ¹³CNMR, IR, MS and EA.
authors.affiliation: College of Pharmacy, Xuzhou Medical College, Xuzhou 221004, China.
authors.forename: Youguang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Min
authors.initials: M
authors.lastname: Sun
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Mingdong
authors.initials: M
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Ji
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D000077156:Gefitinib; D006801:Humans; D008297:Male; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C568546:3-methoxyl-2-(3-(4-methylpiperazin-1-yl)propoxy)-10-bromo-8H-quinazolino(4, 3-b) quinazolin -8'one; D000470:Alkaloids; D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D052999:Quinazolinones; D000077156:Gefitinib