title: Molecular epidemiology of the rabies virus in Slovenia 1994-2010.
abstract: A molecular epidemiology study was performed on a selection of 30 rabies-positive brain samples collected between 1994 and 2010 in Slovenia and originating from the red fox (n=19), badger (n=3), cattle (n=3), dog (n=2), cat (n=1), marten (n=1) and horse (n=1). Based on the comparison of 1092 and 672 nucleotide sequences of nucleoprotein (N) and partial glycoprotein (G) gene regions, a low genetic diversity of the circulating strains was detected, but both phylogenetic trees were consistent with the topology where partial nucleoprotein or glycoprotein genes were used. A high sequence identity in the N and G gene to rabies virus isolates from neighbouring countries was found. The Slovenian strains were clearly different from the vaccine strains SAD B19 and SAD Bern, which have been used in Slovenia since 1988.
authors.affiliation: University of Ljubljana, Veterinary Faculty, Institute of Microbiology and Parasitology, Virology Unit, Gerbičeva 60, 1115 Ljubljana, Slovenia.
authors.forename: D
authors.initials: D
authors.lastname: Rihtarič
authors.forename: P
authors.initials: P
authors.lastname: Hostnik
authors.forename: J
authors.initials: J
authors.lastname: Grom
authors.forename: I
authors.initials: I
authors.lastname: Toplak
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D002415:Cats / Q000821:virology; D002417:Cattle / Q000821:virology; D004285:Dogs / Q000821:virology; D005589:Foxes / Q000821:virology; D014644:Genetic Variation; D006023:Glycoproteins / Q000235:genetics; D006736:Horses / Q000821:virology; D017720:Molecular Epidemiology; D045969:Mustelidae / Q000821:virology; D009698:Nucleoproteins / Q000235:genetics; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D011818:Rabies / Q000453:epidemiology* / Q000662:veterinary; D011820:Rabies virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D017423:Sequence Analysis, RNA; D017524:Slovenia / Q000453:epidemiology; D014759:Viral Envelope Proteins / Q000235:genetics
chemical_list: D000956:Antigens, Viral; D006023:Glycoproteins; D009698:Nucleoproteins; D012367:RNA, Viral; D014759:Viral Envelope Proteins; C064951:glycoprotein G, Rabies virus