title: SmpB as the handyman of tmRNA during trans-translation.
abstract: In the recent years, a wealth of genetic, biochemical and structural data focusing on various steps of bacterial trans-translation was reported. The early events, from stalled ribosome recognition, pre-accommodation to translocation have been recently investigated in great details. In comparison, the later events including 'elongation-termination' onto tmRNA reading frame and ribosome recycling are much less known. What follows is a summary of those data together with our personal view of the dynamics of trans-translation, with emphasis to the pivotal and leading roles that the SmpB protein has, being the essential conductor during the whole process.
authors.affiliation: Université de Rennes 1, INSER M U835-UPRE S EA2311, Laboratoire de Biochimie Pharmaceutique, Rennes, France.
authors.forename: Brice
authors.initials: B
authors.lastname: Felden
authors.forename: Reynald
authors.initials: R
authors.lastname: Gillet
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011132:Polyribosomes / Q000378:metabolism; D014176:Protein Biosynthesis; D012329:RNA, Bacterial / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012269:Ribosomal Proteins / Q000378:metabolism
chemical_list: D012329:RNA, Bacterial; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C430328:small protein B; C096222:tmRNA