title: [Effects on endocrine system of female rats exposed to chronic arsenic].
abstract: OBJECTIVE
  To study the effect on endocrine system of female rats exposed to chronic arsenic.
  
  
  METHODS
  50 female Wistar rats were randomly divided into five groups: control group, 0.05, 0.1, 0.2 and 0.4 microg/ml arsenic groups. The hormone levels were determined by RIA exposing arsenic for 32 weeks.
  
  
  RESULTS
  The hormone levels of female rats were disorder in different arsenic groups. E2, P level increased and LH level decreased in arsenic groups compared to controls, but there were no significant differences( P > 0.05). FSH and PRL level increased in low arsenic group and decreased in high arsenic groups (P > 0.05). GnRH and Cort level increased in arsenic groups, and GnRH level obviously increased in 0.4 microg/ml group and Cort level obviously increased in 0.1 and 0.4 microg/ml groups (P < 0.05).
  
  
  CONCLUSIONS
  The hormone levels were disordered in rats exposed to chronic arsenic.
authors.affiliation: Inner Mongolia Medical College, Huhhot 010110, China. gzw84325@163.com
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Guo
authors.forename: Hongyu
authors.initials: H
authors.lastname: Guo
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Xia
mesh_terms: D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D003348:Cortisone / Q000097:blood; D052244:Endocrine Disruptors / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D011374:Progesterone / Q000097:blood; D051381:Rats; D017208:Rats, Wistar
chemical_list: D052244:Endocrine Disruptors; D012739:Gonadal Steroid Hormones; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D001151:Arsenic; D003348:Cortisone