title: Glucocorticoids and cardiovascular risk factors.
abstract: Glucocorticoids remain a valuable and necessary component of therapy for many diseases. Nonetheless, sustained glucocorticoid treatment increases potential for future cardiovascular disease through multiple pathways, resulting in a tradeoff between benefit and harm. This article explores the potential mechanisms of glucocorticoid-induced hyperglycemia and dyslipidemia. Interactions between glucocorticoids and other potential cardiovascular risk factors are also reviewed. Safe, alternate strategies for minimizing the need for glucocorticoids are urgently needed.
authors.affiliation: Division of Endocrinology and Diabetes and Bone Disease, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. Erika.strohmayer@mountsinai.org
authors.forename: Erika A
authors.initials: EA
authors.lastname: Strohmayer
authors.forename: Lawrence R
authors.initials: LR
authors.lastname: Krakoff
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology; D050171:Dyslipidemias / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D015995:Prevalence; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001786:Blood Glucose; D005938:Glucocorticoids; D008055:Lipids