title: Birth outcomes following self-inflicted poisoning during pregnancy, California, 2000 to 2004.
abstract: OBJECTIVE
  To describe birth outcomes following intentional acute poisoning during pregnancy.
  
  
  METHODS
  California Linked Vital Statistics-Patient Discharge Database, 2000 to 2004.
  
  
  METHODS
  Pregnant women age 15 to 44, who had a singleton live birth or fetal death that occurred between gestational ages 20 and 42 weeks who were discharged from the hospital for an intentional poisoning were compared to pregnant women discharged from the hospital for any nonpoisoning diagnosis. Intentional acute poisoning hospital discharges were identifed by the presence of an ICD-9-CM E-Codes E950-E952 (suicide, attempted suicide and self-inflicted injuries specified as intentional.)
  
  
  METHODS
  Through a retrospective cohort design, birth outcomes including low birth weight; preterm birth; fetal, neonatal, and infant death; and congenital anomalies were identified by the presence of ICD-9-CM diagnosis codes or by notation in the dataset.
  
  
  RESULTS
  There were 430 hospital discharges for an intentional poisoning during pregnancy documented in the dataset (rate=25.87/100,000 person years). The rate of intentional poisoning was greatest in the first weeks of gestation and declined with increasing gestational age. Analgesics, antipyretics, and antirheumatics were most commonly implicated. Adverse birth outcomes associated with intentional poisoning included preterm birth (odds ratio [OR]=1.34; 95% Confidence Interval [CI] [1.01, 1.77]), low birth weight (OR=1.49; 95% CI [1.04, 2.12]), and circulatory system congenital anomalies (OR=2.17; 95% CI [1.02, 4.59]).
  
  
  CONCLUSIONS
  Intentional acute poisoning during pregnancy was associated with several adverse birth outcomes; however, these relationships may be confounded by concomitant maternal substance abuse.
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. candacekmcclure@gmail.com
authors.forename: Candace K
authors.initials: CK
authors.lastname: McClure
authors.forename: Thelma E
authors.initials: TE
authors.lastname: Patrick
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Katz
authors.forename: Sheryl F
authors.initials: SF
authors.lastname: Kelsey
authors.forename: Harold B
authors.initials: HB
authors.lastname: Weiss
mesh_terms: D000293:Adolescent; D000328:Adult; D001294:Attitude to Health; D002140:California / Q000453:epidemiology; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D008429:Maternal Welfare / Q000706:statistics & numerical data*; D009035:Mothers / Q000523:psychology* / Q000706:statistics & numerical data; D016017:Odds Ratio; D010343:Patient Admission / Q000706:statistics & numerical data; D010351:Patient Discharge / Q000706:statistics & numerical data; D011041:Poisoning / Q000453:epidemiology* / Q000523:psychology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology* / Q000523:psychology; D012189:Retrospective Studies; D012649:Self Concept; D016728:Self-Injurious Behavior / Q000453:epidemiology* / Q000523:psychology; D013315:Stress, Psychological / Q000453:epidemiology; D055815:Young Adult