title: Exploratory study on domain-specific determinants of opiate-dependent individuals' quality of life.
abstract: OBJECTIVE
  Studies on determinants of quality of life (QoL) among opiate-dependent individuals are scarce. Moreover, findings concerning the role of severity of drug use are inconsistent. This exploratory study investigates the association between domain-specific QoL and demographic, social, person, health and drug-related variables, and potential indirect effects of current heroin use on opiate-dependent individuals' QoL.
  
  
  METHODS
  A cohort of opiate-dependent individuals who started outpatient methadone treatment at least 5 years previously (n = 159) were interviewed about their current QoL, psychological distress, satisfaction with methadone treatment and the severity of drug-related problems using the Lancashire Quality of Life Profile, the Brief Symptom Inventory, the Verona Service Satisfaction Scale for Methadone Treatment and the EuropASI.
  
  
  RESULTS
  None of the QoL domains were defined by the same compilation of determinants. No direct effect of current heroin use on QoL was retained, but path analyses demonstrated its indirect effects on the domains of 'living situation', 'finances' and 'leisure and social participation'.
  
  
  CONCLUSIONS
  These findings illustrate the particularity of each QoL domain and the need for a multidimensional approach to the concept. The relationship between current heroin use and various domains of opiate-dependent individuals' QoL is complex, indirect and mediated by psychosocial and treatment-related variables.
authors.affiliation: Department of Orthopedagogics, Ghent University, Belgium. Jessica.demaeyer @ ugent.be
authors.forename: J
authors.initials: J
authors.lastname: De Maeyer
authors.forename: W
authors.initials: W
authors.lastname: Vanderplasschen
authors.forename: J
authors.initials: J
authors.lastname: Lammertyn
authors.forename: C
authors.initials: C
authors.lastname: van Nieuwenhuizen
authors.forename: E
authors.initials: E
authors.lastname: Broekaert
mesh_terms: D000328:Adult; D000553:Ambulatory Care / Q000379:methods / Q000523:psychology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009293:Opioid-Related Disorders / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy*; D011788:Quality of Life / Q000523:psychology*; D016320:Substance Abuse Treatment Centers / Q000379:methods