title: Regulation and function of IL-17A- and IL-22-producing γδ T cells.
abstract: The regulation of IL-17A and IL-22 production differs between human and murine γδ T cells. We find that human γδ T cells expressing Vγ2Vδ2 T cell receptors are peripherally polarized to produce IL-17A or IL-22, much like CD4 αβ Th17 T cells. This requires IL-6, IL-1β, and TGF-β, whereas expansion and maintenance requires IL-23, IL-1β, and TGF-β. In contrast, IL-17A and IL-22 production by murine γδ T cells is innately programmed during thymic ontogeny but requires IL-23 and IL-1β for maintenance. Murine γδ cells producing IL-17A and IL-22 play important roles in microbial, autoimmune, and inflammatory responses. However, the roles played by human IL-17A- and IL-22-producing γδ T cells are less clear but are also likely to be important. These observations highlight differences between humans and murine γδ T cells and underscore the importance of IL-17A- and IL-22-producing γδ T cells.
authors.affiliation: Division of Immunology, Department of Internal Medicine and the Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, EMRB 400F, Iowa City, IA 52242, USA.
authors.forename: Kristin J
authors.initials: KJ
authors.lastname: Ness-Schwickerath
authors.forename: Craig T
authors.initials: CT
authors.lastname: Morita
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology; D000818:Animals; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology* / Q000378:metabolism; D007378:Interleukins / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D018448:Models, Immunological; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D013950:Thymus Gland / Q000276:immunology / Q000378:metabolism; D000097043:Interleukin-22
chemical_list: D020381:Interleukin-17; D007378:Interleukins; D016692:Receptors, Antigen, T-Cell, gamma-delta; D000097043:Interleukin-22