title: Prieurianin Causes Weight Loss in Diet-Induced Obese Mice and Inhibits Adipogenesis in Cultured Preadipocytes.
abstract: The global increase in the incidence of obesity has emerged as one of the most serious public health risks in recent years. Despite the enormity of the obesity pandemic, there are currently only two FDA-approved therapies for its treatment and these drugs exhibit modest efficacy and have limiting side effects. Prieurianin is a plant limonoid product that deters feeding in insect larvae. We investigated in this study the effects of prieurianin on weight loss and adipogenesis. Our results showed that prieurianin causes weight loss by reducing energy intake in obese mice on high-calorie diet. We also found that prieurianin is anti-adipogenic in cultured preadipocytes and adipocytes by inhibiting proliferation and differentiation of preadipocytes into adipocytes, and induces either dedifferentiation or delipidation of mature adipocytes. Whether prieurianin can potentially be used for obesity treatment in human warrants further investigation.
authors.affiliation: Department of Medicine, University of Toledo, College of Medicine, Toledo, OH, United States.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kablan
authors.forename: Rudel A
authors.initials: RA
authors.lastname: Saunders
authors.forename: Maria
authors.initials: M
authors.lastname: Szkudlarek-Mikho
authors.forename: Andrew J B
authors.initials: AJ
authors.lastname: Chin
authors.forename: Raul M
authors.initials: RM
authors.lastname: Bosio
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Fujii
authors.forename: Joseph
authors.initials: J
authors.lastname: Shapiro
authors.forename: Khew-Voon
authors.initials: KV
authors.lastname: Chin