title: Assessing the fractal structure of heart rate by the temporal spectrum of scale exponents: a new approach for detrended fluctuation analysis of heart rate variability.
abstract: Detrended fluctuation analysis (DFA) is the most popular method for assessing the fractal characteristics of heart rate (HR). Traditionally, short-term and long-term scale coefficients, α(1) and α(2), are calculated from DFA. We recently showed that the traditional approach oversimplifies a more complex phenomenon better represented by a continuous spectrum of scale coefficients. In this paper we present a DFA based method for describing the HR fractal dynamics with a temporal spectrum of scale exponents, α(t), rather than by a model of lumped parameters, α(1) and α(2). Since α(t) is a function of the temporal scale, its interpretation is facilitated when conditions with different mean HR are compared. In this work, we reanalyze HR data, collected by our group in previous studies, by applying the proposed α(t) spectrum. We quantify the effects of gender, ageing, posture and activity level, and the alterations induced by exposure to high and very-high altitude hypoxia, on α(t). Most of the results may be interpreted in terms of changes of cardiac autonomic regulation, and indicate clearly that the new proposed DFA spectrum provides a more faithful and interpretable description of the HR fractal dynamics than traditional α(1) and α(2) scale coefficients.
authors.affiliation: Don C. Gnocchi Foundation, Milan, Italy. pcastiglioni@dongnocchi.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Castiglioni
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Parati
authors.forename: Carolina
authors.initials: C
authors.lastname: Lombardi
authors.forename: Luc
authors.initials: L
authors.lastname: Quintin
authors.forename: Marco
authors.initials: M
authors.lastname: Di Rienzo
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000367:Age Factors; D000532:Altitude Sickness / Q000503:physiopathology; D001285:Atropine / Q000494:pharmacology; D004562:Electrocardiography / Q000706:statistics & numerical data*; D005260:Female; D017709:Fractals; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D017711:Nonlinear Dynamics; D010276:Parasympatholytics / Q000494:pharmacology; D011187:Posture / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology; D012016:Reference Values; D012737:Sex Factors; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D014630:Vagus Nerve / Q000187:drug effects / Q000503:physiopathology; D055815:Young Adult
chemical_list: D000319:Adrenergic beta-Antagonists; D010276:Parasympatholytics; D001285:Atropine; D011433:Propranolol