title: Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts.
abstract: Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantify the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation period). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.
authors.affiliation: Division of Biomedical Engineering, Oregon Health & Science University, Portland, OR, 97239, USA.
authors.forename: Aiping
authors.initials: A
authors.lastname: Liu
authors.forename: Andrew
authors.initials: A
authors.lastname: Nickerson
authors.forename: Aaron
authors.initials: A
authors.lastname: Troyer
authors.forename: Xin
authors.initials: X
authors.lastname: Yin
authors.forename: Robert
authors.initials: R
authors.lastname: Cary
authors.forename: Kent
authors.initials: K
authors.lastname: Thornburg
authors.forename: Ruikang
authors.initials: R
authors.lastname: Wang
authors.forename: Sandra
authors.initials: S
authors.lastname: Rugonyi