title: The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer.
abstract: Glutathione S-transferase P is abundantly expressed in some mammalian tissues, particularly those associated with malignancies. While the enzyme can catalyze thioether bond formation between some electrophilic chemicals and GSH, novel nondetoxification functions are now ascribed to it. This review summarizes recent material that implicates GSTP in mediating S-glutathionylation of specific clusters of target proteins and in reactions that define a negative regulatory role in some kinase pathways through ligand or protein:protein interactions. It is becoming apparent that GSTP participates in the maintenance of cellular redox homeostasis through a number of convergent and divergent mechanisms. Moreover, drug platforms that have GSTP as a target have produced some interesting preclinical and clinical candidates.
authors.affiliation: Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA. tewk@musc.edu
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Tew
authors.forename: Yefim
authors.initials: Y
authors.lastname: Manevich
authors.forename: Christina
authors.initials: C
authors.lastname: Grek
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiong
authors.forename: Joachim
authors.initials: J
authors.lastname: Uys
authors.forename: Danyelle M
authors.initials: DM
authors.lastname: Townsend
mesh_terms: D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D005982:Glutathione Transferase; D005978:Glutathione