title: Synthesis and characterization of high-quality skin-cooling sheets containing thermosensitive poly(N-isopropylacrylamid).
abstract: Poly(N-isopropylacrylamide) (PNIPAAm) is the most popular thermosensitive polymer, and exhibits a low critical solution temperature of approximately 32°C. This study aimed to examine the usefulness of new cooling sheets, which are manufactured using a thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) material. We prepared cooling-hydrogel sheets containing PNIPAAm (PNIPAAm sheet). We measured the skin temperature on the arms of the subjects using a thermograph and compared the usefulness of the PNIPAAm sheet and a control cooling-hydrogel sheet that did not contain the PNIPAAm mixture. Thermographic measurements obtained 40 min after the treatment with the cooling sheets showed the skin temperature of the subjects treated with the 3.% (w/w) PNIPAAm sheets to be significantly lower than that of the subjects treated with the control cooling-hydrogel sheet (p < 0.005). Compared with the control sheet, the cooling effect of the new PNIPAAm sheet also persisted for a longer duration (up to 100 min). The PNIPAAm sheets exhibited excellent cooling effects. This sheet may therefore be useful for lowering the body temperature of patients with high-grade fever, such as fever due to influenza infection.
authors.affiliation: Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takegami
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Norisugi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagatsuma
authors.forename: Koji
authors.initials: K
authors.lastname: Takata
authors.forename: Mati Ur
authors.initials: MU
authors.lastname: Rehman
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Hideharu
authors.initials: H
authors.lastname: Yokoi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujiki
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Makino
authors.forename: Tadamichi
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000178:Acrylamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000180:Acrylic Resins; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012881:Skin Temperature / Q000187:drug effects*
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D011108:Polymers; C052970:poly-N-isopropylacrylamide