title: Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases.
abstract: A case of sporadic Burkitt lymphoma (sBL) presenting with jaw and lid involvement in a diabetic adult African American female and a review of adult orbital Burkitt lymphoma cases are presented. Lid edema, visual loss, ophthalmoparesis, proptosis, and sinusitis progressed over 4 weeks despite antibiotic and steroid treatment. Upper lid biopsy histopathological evaluation and immunophenotyping revealed a homogenous mass of atypical CD10 and CD20-negative B-cells and tingible body macrophages yielding a "starry sky" appearance. Cytogenetic analysis detected a minor variant c-MYC translocation, but no Epstein-Barr virus RNA. Detection of multiple lesions prompted a diagnosis of stage IV disease that totally regressed following radiation and chemotherapy. Review results of the six adult orbital sBL cases support a poor prognosis and a heightened suspicion of variant CD10, CD20 and BCL6 positive sBL in adults presenting with jaw pain and rapidly progressive orbital symptoms, particularly in female, African American, and diabetic patients.
authors.affiliation: Department of Ophthalmology.
authors.forename: John
authors.initials: J
authors.lastname: Carmody
authors.forename: Raghunath P
authors.initials: RP
authors.lastname: Misra
authors.forename: Marlyn P
authors.initials: MP
authors.lastname: Langford
authors.forename: William A
authors.initials: WA
authors.lastname: Byrd
authors.forename: Lauren
authors.initials: L
authors.lastname: Ditta
authors.forename: Bryan
authors.initials: B
authors.lastname: Vekovius
authors.forename: Donald E
authors.initials: DE
authors.lastname: Texada