title: Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans.
abstract: OBJECTIVE
  To evaluate the rate and degree of osseointegration at chemically modified moderately rough, hydrophilic (SLActive) and moderately rough, hydrophobic (SLA) implant surfaces during early phases of healing in a human model.
  
  
  METHODS
  The devices used for this study of early healing were 4 mm long and 2.8 mm in diameter and had either an SLActive chemically modified or a moderately rough SLA surface configuration. These devices were surgically installed into the retro-molar area of 49 human volunteers and retrieved after 7, 14, 28 and 42 days of submerged healing. A 5.2-mm-long specially designed trephine with a 4.9 mm inside diameter, allowing the circumferential sampling of 1 mm tissue together with the device was applied. Histologic ground sections were prepared and histometric analyses of the tissue components (i.e. old bone, new bone, bone debris and soft tissue) in contact with the device surfaces were performed.
  
  
  RESULTS
  All device sites healed uneventfully. All device surfaces were partially coated with bone debris. A significant fraction of this bone matrix coating became increasingly covered with newly formed bone. The process of new bone formation started already during the first week in the trabecular regions and increased gradually up to 42 days. The percentage of direct contact between newly formed bone and the device (bone-to-implant contact) after 2 and 4 weeks was more pronounced adjacent to the SLActive than to the SLA surface (14.8% vs. 12.2% and 48.3% vs. 32.4%, respectively), but after 42 days, these differences were no longer evident (61.6% vs. 61.5%).
  
  
  CONCLUSIONS
  While healing showed similar characteristics with bone resorptive and appositional events for both SLActive and SLA surfaces between 7 and 42 days, the degree of osseointegration after 2 and 4 weeks was superior for the SLActive compared with the SLA surface.
authors.affiliation: Prince Philip Dental Hospital, The University of Hong Kong, Hong Kong, SAR PR China. nplang@dial.eunet.ch
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
authors.forename: Giovanni E
authors.initials: GE
authors.lastname: Salvi
authors.forename: Guy
authors.initials: G
authors.lastname: Huynh-Ba
authors.forename: Saso
authors.initials: S
authors.lastname: Ivanovski
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Donos
authors.forename: Dieter D
authors.initials: DD
authors.lastname: Bosshardt
mesh_terms: D000328:Adult; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017267:Dental Prosthesis Design; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008875:Middle Aged; D016348:Osseointegration; D013499:Surface Properties; D013997:Time Factors; D055815:Young Adult
chemical_list: D015921:Dental Implants