title: Diversity of killer cell immunoglobulin-like receptor genes in four ethnic groups in China.
abstract: Killer cell immunoglobulin-like receptors (KIRs) show extensive variation in terms of gene content and allelic polymorphisms among different populations. The aim of this study was to analyze the distribution of KIR genes in the Bulang, Nu, Yugu, and Zhuang ethnic groups, which belong to four different language families in China, and thus to provide basic KIR gene and genotype data for these Chinese ethnic groups. Genotyping of 16 KIR genes was performed in 425 unrelated individuals using the polymerase chain reaction-sequence-specific oligonucleotide probe method with the Luminex MultiAnalyte Profiling System. The four framework KIR genes were detected in all four ethnic groups. The activating KIR genes as well as the inhibitory KIR genes showed extreme diversity among these four populations. A total of 35 distinct KIR genotypes were identified, one of which was previously unknown. The four most common genotypes were identified in all four populations and comprised 66.1~91.1% of all the genotypes. The group A haplotype occurred more frequently than the group B haplotype in the Nu, Yugu, and Zhuang populations, as in other East Asian populations. In contrast, the group A and group B haplotypes occurred equally in the Bulang population. The results of the present study suggested that the KIR genes and genotypes are diverse in these four ethnic groups, and each ethnic group has its own characteristic KIR distribution. The findings with respect to KIR gene diversity in these four populations should provide relevant genomic diversity data for the future study of viral infections, autoimmune diseases, and reproductive fitness.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Yao
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Yufen
authors.initials: Y
authors.lastname: Tao
authors.forename: Keqin
authors.initials: K
authors.lastname: Lin
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Yu
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Yang
authors.forename: Wen
authors.initials: W
authors.lastname: Yi
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Huang
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Jiayou
authors.initials: J
authors.lastname: Chu
authors.forename: Li
authors.initials: L
authors.lastname: Shi
mesh_terms: D002681:China / Q000208:ethnology; D056426:Genetic Loci; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology
chemical_list: D054340:Receptors, KIR