title: Strain differences in neoplastic response to dmba-induced uterine vascular tumors in mice.
abstract: We examined strain differences in neoplastic response to DMBA-induced uterine vascular tumors in mice. Female BALB/c, C57BL, C3H, SWR/J, GRS/A and DDD/1-Mtv-2 mice were treated with a single intraperitoneal injection (ip) of 1 mg of 7,12-dimethylbenz(a)anthracene (DMBA) at 4 weeks of age, and observed until they were 32 weeks of age. The BALB/c, C57BL, C3H strains showed a high incidence of uterine vascular tumors (87%, 93%, and 90%, respectively), while in contrast, the SWR/J, GRS/A, and DDD/1-Mtv-2 strains showed a low incidence (17%, 11% and 15%, respectively); these differences were striking. The mice of American origin (BALB/c, C57BL and C3H) appeared to be susceptible to DMBA, while those of European origin (SWR/J, GRS/A and DDD/1-Mtv-2) were resistant to the induction of uterine vascular tumors.
authors.forename: A
authors.initials: A
authors.lastname: Tsubura
authors.forename: H
authors.initials: H
authors.lastname: Senzaki
authors.forename: T
authors.initials: T
authors.lastname: Oyaizu
authors.forename: Y
authors.initials: Y
authors.lastname: Fujita
authors.forename: S
authors.initials: S
authors.lastname: Morii