title: Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor.
abstract: Advances in molecular medicines have led to identification of promising targets on cellular and molecular levels. These targets are located in extracellular and intracellular compartments. The latter include cytosol, nucleus, mitochondrion, Golgi apparatus and endoplasmic reticulum. This report gives an overview on the barriers to delivering nanomedicines to various target sites within a solid tumor, the experimental approaches to overcome such barriers, and the potential utility of nanotechnology.
authors.affiliation: Division of Pharmaceutics, College of Pharmacy, the Ohio State University, Columbus, OH 43210, USA.
authors.forename: Yinghuan
authors.initials: Y
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: M Guillaume
authors.initials: MG
authors.lastname: Wientjes
authors.forename: Jessie L-S
authors.initials: JL
authors.lastname: Au
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*