title: Preoperative chemotherapy for operable breast cancer is associated with better compliance with adjuvant therapy in matched stage II and IIIA patients.
abstract: BACKGROUND
  Preoperative chemotherapy (PC) for operable breast cancer has shown significant benefits in prospective trials. Many patients are treated in the community setting and some may question the applicability of PC outside the university setting.
  
  
  METHODS
  Retrospective review was performed of stage II and IIIA breast cancer patients treated from January 2002 to July 2009. Fifty-three of 57 patients who underwent PC were matched based on age, tumor size, and hormone receptor status with 53 patients who did not undergo PC. Differences in patient compliance with physician recommendations for all types of adjuvant therapy were evaluated. Crude odds ratios and adjusted odds ratios derived from conditional logistic regression models were calculated.
  
  
  RESULTS
  There were 106 patients included. Patient compliance with chemotherapy was better in the PC group than in the adjuvant chemotherapy (AC) group (100% versus 70%; p = .0001). Similarly, more patients in the PC group completed radiation therapy (96% versus 65%; p = .0003) and initiated hormonal therapy (100% versus 62%; p = .0001). Conditional logistic regression revealed that higher pathologic stage and current cigarette smoking were associated with poorer compliance with chemotherapy. For radiation therapy, the univariate model revealed that compliance with chemotherapy and being employed were associated with completion of radiation, whereas current cigarette smoking and larger pathologic size were associated with poorer compliance with radiation. For hormonal therapy, current cigarette smokers were more likely to be noncompliant with initiation of hormonal therapy.
  
  
  CONCLUSIONS
  PC for operable breast cancer can improve patient compliance with chemotherapy. Current cigarette smokers were more likely to be noncompliant with all types of adjuvant therapy.
authors.affiliation: Maricopa Medical Center, Department of Surgery, Phoenix, Arizona, USA. Komenaka@hotmail.com
authors.forename: Ian K
authors.initials: IK
authors.lastname: Komenaka
authors.forename: Chiu-Hsieh
authors.initials: CH
authors.lastname: Hsu
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Martinez
authors.forename: Marcia E
authors.initials: ME
authors.lastname: Bouton
authors.forename: Boo Ghee
authors.initials: BG
authors.lastname: Low
authors.forename: Jason A
authors.initials: JA
authors.lastname: Salganick
authors.forename: Jesse
authors.initials: J
authors.lastname: Nodora
authors.forename: Michael L
authors.initials: ML
authors.lastname: Hibbard
authors.forename: Chandra
authors.initials: C
authors.lastname: Jha
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D016015:Logistic Models; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009367:Neoplasm Staging; D010349:Patient Compliance; D011300:Preoperative Care; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012907:Smoking