title: [A case of xp11.2 translocation renal cell carcinoma].
abstract: Xp11.2/TFE3 translocation renal cell carcinoma (RCC), a recently classified distinct subtype, is a rare tumor that usually affects children and adolescents. The morphology and biological behavior are not widely recognized, Xp11.2 translocation RCC is suggestive of early metastases despite the small tumor size. The definitive diagnosis requires the evidence of several different reciprocal translocations involving the TFE3 gene located on chromosome Xp11.2. Here, we present a case of Xp11.2 translocation RCC in an 18-yearold male. He was referred to our hospital because of a right renal tumor with macroscopic hematuria and right flank colic. The radiographic evaluation including magnetic resonance imaging (MRI) suggested it to be a typical papillary renal cell carcinoma or benign renal tumor. He underwent laparoscopic nephrectomy against the repeat symptom in spite of small tumor (3.5 cm in diameter). The immunohistochemical study revealed nuclear staining for TFE3 protein in the cancer cells. The urologic and radiologic outcomes were satisfactory after more than 1 year of follow-up.
authors.affiliation: The Department of Urology, Graduate School of Medicine, Gifu University.
authors.forename: Kengo
authors.initials: K
authors.lastname: Horie
authors.forename: Mina
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Kosei
authors.initials: K
authors.lastname: Miwa
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Minamidate
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Yokoi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakano
authors.forename: Takashi
authors.initials: T
authors.lastname: Deguchi
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ehara
authors.forename: Nami
authors.initials: N
authors.lastname: Asano
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Hirose
mesh_terms: D000293:Adolescent; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D041321:Chromosomes, Human, X; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C069203:TFE3 protein, human