title: Surface modified dendrimers: synthesis and characterization for cancer targeted drug delivery.
abstract: Dendrimers represents a highly branched three-dimensional structure that provides a high degree of surface functionality and versatility. PAMAM dendrimers are used as well-defined nanocontainers to conjugate, complex or encapsulate therapeutic drugs or imaging moieties. Star-burst [PAMAM] dendrimers represent a superior carrier platform for drug delivery. The present study was aimed at synthesis of a surface modified dendrimer for cancer targeted drug delivery system. For this 4.0 G PAMAM dendrimer was conjugated with Gallic acid [GA] and characterized through UV, IR, ¹H NMR and mass spectroscopy. Cytotoxicity study of dendrimer conjugate was carried out against MCF-7 cell line using MTT assay. The study revealed that the conjugate is active against MCF-7 cell line and might act synergistically with anti-cancer drug and gallic acid-dendrimer conjugate might be a promising nano-platform for cancer targeting and cancer diagnosis.
authors.affiliation: Smriti College of Pharmaceutical Education, 4/1, Pipliya Kumar Kakad, Dewas Naka, Indore (M.P.) 452010, India.
authors.forename: Anupama
authors.initials: A
authors.lastname: Sharma
authors.forename: Surya Prakash
authors.initials: SP
authors.lastname: Gautam
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Gupta
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000737:chemistry* / Q000633:toxicity; D005707:Gallic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D036103:Nanotechnology; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; C104700:PAMAM Starburst; D005707:Gallic Acid