title: The ret protooncogene is expressed in normal human parafollicular thyroid-cells.
abstract: The RET proto-oncogene has been demonstrated to be expressed in medullary thyroid carcinomas and pheochromocytomas, and was mutated in patients with the multiple endocrine neoplasia type 2A (MEN 2A). The results presented herein show its expression in normal human thyroid parafollicular C cells. Since RET is predicted to encode a receptor for a still unknown ligand, these data confirm its involvement in the regulation and growth of these cells.
authors.affiliation: UNIV NAPLES,FAC MED & CHIRURG 2,DIPARTIMENTO BIOL & PATOL CELLULARE & MOLEC,I-80131 NAPLES,ITALY. CTR HOSP LYON SUD,HISTOL & CYTOL LAB,F-69310 PIERRE BENITE,FRANCE. FAC MED LYON SUD,CNRS,URA 1454,F-69600 OULLINS,FRANCE. HOP LANTIQUAILLE,ANAT PATHOL LAB,F-69321 LYON,FRANCE. UNIV REGGIO CALABRIA,FAC MED & CHIRURG CATANZARO,DIPARTIMENTO MED SPERIMENTALE & CLIN,I-88100 CATANZARO,ITALY.
authors.forename: N
authors.initials: N
authors.lastname: Fabien
authors.forename: C
authors.initials: C
authors.lastname: Paulin
authors.forename: M
authors.initials: M
authors.lastname: Santoro
authors.forename: N
authors.initials: N
authors.lastname: Berger
authors.forename: M
authors.initials: M
authors.lastname: Grieco
authors.forename: P
authors.initials: P
authors.lastname: Dubois
authors.forename: A
authors.initials: A
authors.lastname: Fusco