title: Voxel-based morphometric study of brain volume changes in patients with Alzheimer's disease assessed according to the Clinical Dementia Rating score.
abstract: We evaluated the volume reduction of gray matter (GM) and white matter (WM) in patients with an Alzheimer's disease (AD) assessment based on the Clinical Dementia Rating (CDR) score. Patients with AD (n=61), with no subcortical WM ischemia, and healthy control patients (n=33) underwent T1-weighted spoiled gradient echo sequences, which were analyzed using voxel-based morphometry. Global GM volume reduction was observed in patients with a CDR score of 1 or a CDR score of 2, and WM volume reduction was observed in patients with a CDR score of 2. Regional GM volume reduction was found in the right inferior frontal gyrus, bilateral dorso-lateral and medial temporal lobes; WM volume reduction was found in the bilateral temporal subcortex (family-wise error, p<0.01). A CDR score of 0.5 was associated with volume reduction in the left olfactory gyrus. The peak z-score and spatial extent of volume reduction increased with increasing CDR score and were higher on the left side. GM volume reduction increased with increasing CDR scores and suggests a possible pathomechanism of AD.
authors.affiliation: Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, South Korea.
authors.forename: SangYun
authors.initials: S
authors.lastname: Kim
authors.forename: Young Chul
authors.initials: YC
authors.lastname: Youn
authors.forename: Ging-Yuek Robin
authors.initials: GY
authors.lastname: Hsiung
authors.forename: Sam-Yeol
authors.initials: SY
authors.lastname: Ha
authors.forename: Kwang-Yeol
authors.initials: KY
authors.lastname: Park
authors.forename: Hae-Won
authors.initials: HW
authors.lastname: Shin
authors.forename: Don-Kyu
authors.initials: DK
authors.lastname: Kim
authors.forename: Sung-Su
authors.initials: SS
authors.lastname: Kim
authors.forename: Baik Seok
authors.initials: BS
authors.lastname: Kee
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D003704:Dementia / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests