title: Proton dose distribution measurements using a MOSFET detector with a simple dose-weighted correction method for LET effects.
abstract: We experimentally evaluated the proton beam dose reproducibility, sensitivity, angular dependence and depth-dose relationships for a new Metal Oxide Semiconductor Field Effect Transistor (MOSFET) detector. The detector was fabricated with a thinner oxide layer and was operated at high-bias voltages. In order to accurately measure dose distributions, we developed a practical method for correcting the MOSFET response to proton beams. The detector was tested by examining lateral dose profiles formed by protons passing through an L-shaped bolus. The dose reproducibility, angular dependence and depth-dose response were evaluated using a 190 MeV proton beam. Depth-output curves produced using the MOSFET detectors were compared with results obtained using an ionization chamber (IC). Since accurate measurements of proton dose distribution require correction for LET effects, we developed a simple dose-weighted correction method. The correction factors were determined as a function of proton penetration depth, or residual range. The residual proton range at each measurement point was calculated using the pencil beam algorithm. Lateral measurements in a phantom were obtained for pristine and SOBP beams. The reproducibility of the MOSFET detector was within 2%, and the angular dependence was less than 9%. The detector exhibited a good response at the Bragg peak (0.74 relative to the IC detector). For dose distributions resulting from protons passing through an L-shaped bolus, the corrected MOSFET dose agreed well with the IC results. Absolute proton dosimetry can be performed using MOSFET detectors to a precision of about 3% (1 sigma). A thinner oxide layer thickness improved the LET in proton dosimetry. By employing correction methods for LET dependence, it is possible to measure absolute proton dose using MOSFET detectors.
authors.affiliation: National Cancer Center Hospital East, Chiba 277-8577, Japan. rkohno@east.ncc.go.jp
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kohno
authors.forename: Kenji
authors.initials: K
authors.lastname: Hotta
authors.forename: Taeko
authors.initials: T
authors.lastname: Matsuura
authors.forename: Kana
authors.initials: K
authors.lastname: Matsubara
authors.forename: Shie
authors.initials: S
authors.lastname: Nishioka
authors.forename: Teiji
authors.initials: T
authors.lastname: Nishio
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Kawashima
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogino
mesh_terms: D002138:Calibration; D004307:Dose-Response Relationship, Radiation; D004867:Equipment Design; D006801:Humans; D018499:Linear Energy Transfer; D008670:Metals / Q000737:chemistry; D015233:Models, Statistical; D010087:Oxides / Q000737:chemistry; D020959:Polyethylene; D011522:Protons; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods; D011879:Radiotherapy Dosage; D015203:Reproducibility of Results; D012666:Semiconductors; D013696:Temperature
chemical_list: D008670:Metals; D010087:Oxides; D011522:Protons; D020959:Polyethylene