title: Duodenal 7-ethoxycoumarin-o-deethylase activity in colon-cancer patients.
abstract: The biotransformation activity of the mono-oxygenase enzyme, 7-ethoxycoumarin-O-deethylase (EOD), was investigated in the upper digestive tract of colon cancer patients, and compared with patients with and without neoplasia. The three groups studied comprised 23 control, 17 metastasized colon cancer and 16 metastasized breast cancer patients. EOD activity was determined by spectrofluorometry in duodenal biopsies obtained during gastroduodenoscopy. No correlation between the presence of colon or breast cancer and the level of EOD activity was observed. It was concluded that biotransformation enzymes can be easily determined in duodenal biopsies derived during. gastroduodenoscopy. The role of EOD in the biogenesis of colon cancer seems to be limited.
authors.affiliation: UNIV GRONINGEN HOSP,DEPT INTERNAL MED,DIV MED ONCOL,OOSTERSINGEL 59,9713 EZ GRONINGEN,NETHERLANDS. UNIV GRONINGEN HOSP,DEPT INTERNAL MED,DIV GASTROENTEROL,9713 EZ GRONINGEN,NETHERLANDS. UNIV GRONINGEN HOSP,DEPT INTERNAL MED,DIV ENDOCRINOL,9713 EZ GRONINGEN,NETHERLANDS.
authors.forename: A
authors.initials: A
authors.lastname: Cats
authors.forename: J
authors.initials: J
authors.lastname: Kleibeuker
authors.forename: W
authors.initials: W
authors.lastname: Boersma
authors.forename: E
authors.initials: E
authors.lastname: Devries
authors.forename: W
authors.initials: W
authors.lastname: Sluiter
authors.forename: J
authors.initials: J
authors.lastname: Bouman
authors.forename: D
authors.initials: D
authors.lastname: Sleijfer
authors.forename: N
authors.initials: N
authors.lastname: Mulder