title: A multi-centre randomized controlled clinical trial on the treatment of intra-bony defects with enamel matrix derivatives/synthetic bone graft or enamel matrix derivatives alone: results after 12 months.
abstract: OBJECTIVE
  Comparison of the clinical and radiographic outcomes of a combination of enamel matrix derivatives (EMD) and a synthetic bone graft (EMD/SBG) with EMD alone in wide (≥2 mm) and deep (≥4 mm) one- and two- wall intra-bony defects 12 months after treatment.
  
  
  METHODS
  Seventy-three patients with chronic periodontitis and one wide (≥2 mm) and deep (≥4 mm) intra-bony defect were recruited in five centres in Germany. During surgery, defects were randomly assigned to EMD/SBG (test) or EMD (control). Assessments at baseline, after 6 and 12 months included bone sounding, attachment levels, probing pocket depths, bleeding on probing, and recessions. Changes in defect fill were recorded radiographically.
  
  
  RESULTS
  Both treatment modalities led to significant clinical improvements. In the EMD/SBG group a mean defect fill of 2.7 ± 1.9 mm was calculated, in the EMD group the defect fill was 2.8 ± 1.6 mm. A mean gain in clinical attachment of 1.7 ± 2.1 mm in the test group and 1.9 ± 1.7 mm in the control group after 1 year was observed. Radiographic analysis confirmed for both groups that deeper defects were associated with greater defect fill.
  
  
  CONCLUSIONS
  The results show comparable clinical and radiographic outcomes following both treatment modalities 12 months after treatment.
authors.affiliation: Department of Periodontology, University of Giessen, Giessen, Germany. joerg.meyle@dentist.med.uni-giessen.de
authors.forename: Joerg
authors.initials: J
authors.lastname: Meyle
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoffmann
authors.forename: Heinz
authors.initials: H
authors.lastname: Topoll
authors.forename: Bernd
authors.initials: B
authors.lastname: Heinz
authors.forename: Eli
authors.initials: E
authors.lastname: Al-Machot
authors.forename: Pia-Merete
authors.initials: PM
authors.lastname: Jervøe-Storm
authors.forename: Christian
authors.initials: C
authors.lastname: Meiss
authors.forename: Peter
authors.initials: P
authors.lastname: Eickholz
authors.forename: Sören
authors.initials: S
authors.lastname: Jepsen
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000473:pathology; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000601:surgery; D003646:Debridement; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000601:surgery; D005889:Gingival Recession / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D011446:Prospective Studies; D011859:Radiography; D016037:Single-Blind Method; D013524:Surgical Flaps; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018786:Bone Substitutes; D003746:Dental Enamel Proteins; C109069:enamel matrix proteins