title: Identification of 4H,6H-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors.
abstract: Novel squalene synthase inhibitors are disclosed. The design, synthesis, SAR and pharmacological profile of the compounds are discussed.
authors.affiliation: Bayer Pharma AG, Global Drug Discovery, Medicinal Chemistry Wuppertal, Wuppertal, Germany. nils.griebenow@bayer.com
authors.forename: Nils
authors.initials: N
authors.lastname: Griebenow
authors.forename: Anja
authors.initials: A
authors.lastname: Buchmueller
authors.forename: Peter
authors.initials: P
authors.lastname: Kolkhof
authors.forename: Jens
authors.initials: J
authors.lastname: Schamberger
authors.forename: Hilmar
authors.initials: H
authors.lastname: Bischoff
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D015195:Drug Design; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D010080:Oxazoles; D013186:Farnesyl-Diphosphate Farnesyltransferase