title: [A case-control study between gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and paranoid schizophrenia of Han ethnicity in Jilin Province].
abstract: OBJECTIVE
  To investigate an association between gene polymorphisms of FADS 1 (fatty acid desaturase 1) , FADS2 (fatty acid desaturase 2) and ELOVL2 (elongation of very long chain fatty acids (FEN1/ Elo2, SUR4/Elo3, yeast) -like 2) and paranoid schizophrenia of the Han ethnicity in Jilin province of China.
  
  
  METHODS
  We genotyped 3 single nucleotide polymorphisms from 3 candidate genes in 100 paranoid schizophrenia cases and 95 healthy controls using polymerase chain reaction-restriction fragment length polymorphism method. All samples are from Han ethnicity in Jilin province of China.
  
  
  RESULTS
  The genotype distributions of rs174556 in FADS1 gene and rs174617 in FADS2 gene showed no significant difference between case and control groups (P > 0.05). The genotype distribution of rs3756963 in ELOVL2 gene showed significant difference between case group and control group (P < 0.05). The distribution proportion of allele T carriers in case group was higher than that in control group. Trans-phase gene interaction analysis showed that the distribution proportion of combined genotypes included rs3756963 (T/T) was higher in case group than that in control group (P < 0.05).
  
  
  CONCLUSIONS
  rs174556 in FADS1 gene and rs174617 in FADS2 gene may not be associated with paranoid schizophrenia. rs3756963 in ELOVL2 gene may be associated with paranoid schizophrenia.
authors.affiliation: School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Dejia
authors.initials: D
authors.lastname: Xia
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.forename: Jieping
authors.initials: J
authors.lastname: Shi
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Yu
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
mesh_terms: D000123:Acetyltransferases / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases / Q000235:genetics*; D000081031:Fatty Acid Elongases; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012563:Schizophrenia, Paranoid / Q000235:genetics*
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; C000630967:ELOVL2 protein, human; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human; C533241:FADS2 protein, human; D000123:Acetyltransferases; D000081031:Fatty Acid Elongases