title: Chemical constituents of Cordia latifolia and their nematicidal activity.
abstract: Following nematicidal activity-guided isolation studies on the fruits, bark, and leaves of Cordia latifolia, two new constituents, cordinoic acid (=11-oxours-12-ene-23,28-dioic acid; 1) and cordicilin (=2-{[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-3-[4-hydroxy-3-(stearoyloxy)phenyl]propanoic acid; 2) were isolated from the stem and leaves, respectively, together with nine known compounds, namely cordioic and cordifolic acid from the stem bark, latifolicin A-D and rosmarinic acid from the fruits, and cordinol and cordicinol from the leaves. Their structures were determined by means of spectroscopic analyses including 1D- and 2D-NMR techniques. The nematicidal activities of these constituents were determined against the root-knot nematode Meloidogyne incognita. Hundred percent mortality was caused by all of these after 72 h at a 0.125% concentration. Compound 1 and cordioic acid were most active and caused 100% mortality after 24 h at a 0.50% concentration. Furthermore, compound 2, the ester of rosemarinic acid, was found to be more active than the free acid.
authors.affiliation: International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Sabira
authors.initials: S
authors.lastname: Begum
authors.forename: Sobiya
authors.initials: S
authors.lastname: Perwaiz
authors.forename: Bina S
authors.initials: BS
authors.lastname: Siddiqui
authors.forename: Shazia
authors.initials: S
authors.lastname: Khan
authors.forename: Shahina
authors.initials: S
authors.lastname: Fayyaz
authors.forename: Musarrat
authors.initials: M
authors.lastname: Ramzan
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031213:Cordia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D017190:Secernentea Infections / Q000188:drug therapy; D014431:Tylenchoidea / Q000187:drug effects*
chemical_list: D000969:Antinematodal Agents; D010936:Plant Extracts