title: Serum contents of IL-23 and IL-17 in the patients with ulcerative colitis and the clinical significance.
abstract: OBJECTIVE
  To study the serum contents of IL-23 and IL-17 in the patients with ulcerative colitis and the clinical significance.
  
  
  METHODS
  40 patients with ulcerative colitis as UC group and 30 healthy people as control group were selected. The serum contents of IL-23 and IL-17 were determined bII ELISA.
  
  
  RESULTS
  Serum contents of IL-23 AND IL-17 in UC group were higher than those in control group significantly (t=18.76, 21.48, P<0.01). Serum contents of IL-23 and IL-17 increase with the clinical symptoms. Serum contents of IL-23 AND IL-17 in severe patients were higher than those of mild and moderate patients significantly, and serum contents of IL-23 and IL-17 in mild patients were higher than those of moderate patients significantly. Serum contents of IL-23 were positively correlated to IL-17 significantly (r=0.548, P<0.01).
  
  
  CONCLUSIONS
  IL-23 and IL-17 participates in the pathogenesis of ulcerative colitis. IL-23 may play a critical role in the development of UC through inducing production of IL-17.
authors.affiliation: Department of Gastroenterology, First-aid Center, Chongqing, China.
authors.forename: Zi-dan
authors.initials: ZD
authors.lastname: Zheng
authors.forename: Xiao-qiang
authors.initials: XQ
authors.lastname: Wan
authors.forename: Liang-ying
authors.initials: LY
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D053759:Interleukin-23 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23