title: Plantazolicin A and B: structure elucidation of ribosomally synthesized thiazole/oxazole peptides from Bacillus amyloliquefaciens FZB42.
abstract: The structures of the ribosomally synthesized peptide antibiotics from Bacillus amyloliquefaciens FZB42, plantazolicin A and B, have been elucidated by high resolving ESI-MSMS, 2D (1)H-(13)C-correlated NMR spectroscopy as well as (1)H-(15)N-HMQC/(1)H-(15)N-HMBC NMR experiments. (15)N-labeling prior to the experiments facilitated the structure determination, unveiling a hitherto unusual number of thiazoles and oxazoles formed from a linear 14mer precursor peptide. This finding further extends the number of known secondary metabolites from B. amyloliquefaciens and represents a new type of secondary metabolites from the genus Bacillus.
authors.affiliation: Institut für Chemie, Technische Universität Berlin, 10623 Berlin, Germany.
authors.forename: Bahar
authors.initials: B
authors.lastname: Kalyon
authors.forename: Soleiman E
authors.initials: SE
authors.lastname: Helaly
authors.forename: Romy
authors.initials: R
authors.lastname: Scholz
authors.forename: Jonny
authors.initials: J
authors.lastname: Nachtigall
authors.forename: Joachim
authors.initials: J
authors.lastname: Vater
authors.forename: Rainer
authors.initials: R
authors.lastname: Borriss
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000737:chemistry* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012270:Ribosomes / Q000378:metabolism; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D009842:Oligopeptides; D010080:Oxazoles; D013844:Thiazoles; C560834:plantazolicin A; C560835:plantazolicin B