title: Recovery of response to adriamycin and cyclophosphamide by lonidamine in previously treated metastatic breast-cancer patients.
abstract: Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 partial remissions. Disease stability and progression were observed in 8 and 13 cases, respectively. These results were obtained with a marginal toxicity in addition to that already reported for AC therapy, the main additional side effect being myalgia, which was easily manageable in most cases.
authors.affiliation: FDN CLIN LAVORO,PAVIA,ITALY. OSPED COMO,COMO,ITALY. OSPED MAGENTA,MAGENTA,ITALY. OSPED CODOGNO,CODOGNO,ITALY. OSPED MELEGNANO,MELEGNANO,ITALY. OSPED CASTELLANZA,CASTELLANZA,ITALY. OSPED SARONNO,SARONNO,ITALY.
authors.forename: M
authors.initials: M
authors.lastname: Tomirotti
authors.forename: G
authors.initials: G
authors.lastname: Bernardo
authors.forename: C
authors.initials: C
authors.lastname: Epifani
authors.forename: R
authors.initials: R
authors.lastname: Biasioli
authors.forename: R
authors.initials: R
authors.lastname: Franchi
authors.forename: F
authors.initials: F
authors.lastname: Mensi
authors.forename: P
authors.initials: P
authors.lastname: Carnaghi
authors.forename: G
authors.initials: G
authors.lastname: Schieppati
authors.forename: A
authors.initials: A
authors.lastname: Scanni