title: Molecular evolution of human species D adenoviruses.
abstract: Adenoviruses are medium-sized double stranded DNA viruses that infect vertebrates. Human adenoviruses cause an array of diseases. Currently there are 56 human adenovirus types recognized and characterized within seven species (A-G). Of those types, a majority belongs to species D. In this review, the genomic conservation and diversity are examined among human adenoviruses within species D, particularly in contrast to other human adenovirus species. Specifically, homologous recombination is presented as a driving force for the molecular evolution of human adenoviruses and the emergence of new adenovirus pathogens.
authors.affiliation: Howe Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA. USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Robinson
authors.forename: Donald
authors.initials: D
authors.lastname: Seto
authors.forename: Morris S
authors.initials: MS
authors.lastname: Jones
authors.forename: David W
authors.initials: DW
authors.lastname: Dyer
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
mesh_terms: D000260:Adenoviruses, Human / Q000235:genetics*; D019143:Evolution, Molecular; D014644:Genetic Variation; D016679:Genome, Viral; D006801:Humans; D010802:Phylogeny; D011995:Recombination, Genetic; D016415:Sequence Alignment