title: Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction.
abstract: The effect of Cyclovirobuxine D, an active ingredient from Buxus microphylla, was investigated in the potential prevention of cardiac dysfunction in rats with congestive heart failure. Heart failure was induced by left coronary artery occlusion and verified using echocardiography. Cyclovirobuxine D was administered for 30 days (0.5, 1.0 and 2.0mg/kg, ig) and mortality, cardiac function, hemodynamics, microcirculation, histology and ultrastructure assessments were observed. Results from the present study suggest that Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction and supports the potential for Cyclovirobuxine D as a new therapy for heart failure.
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, PR China. yubinruming@sina.com
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
authors.forename: Tai-Hui
authors.initials: TH
authors.lastname: Fang
authors.forename: Gao-Hong
authors.initials: GH
authors.lastname: Lü
authors.forename: Hui-Qin
authors.initials: HQ
authors.lastname: Xu
authors.forename: Jin-Fu
authors.initials: JF
authors.lastname: Lu
mesh_terms: D000818:Animals; D031235:Buxus / Q000737:chemistry*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004452:Echocardiography; D006321:Heart / Q000033:anatomy & histology; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; C032939:cyclovirobuxine D