title: Secondary metabolites from the root wood of Zanthoxylum wutaiense and their antitubercular activity.
abstract: Bioassay-guided fractionation of the root wood of Zanthoxylum wutaiense led to the isolation of five new compounds, wutaipyranol A (1), 8-methoxywutaipyranol A (2), demethoxywutaiensal (3), demethoxywutaiensol (4), and dihydrodemethoxywutaiensol (5), together with six known compounds. Their structures were elucidated by 1D- and 2D-NMR, as well as MS analyses. Among the isolates, wutaipyranol A (1), 8-methoxywutaipyranol A (2), and demethoxywutaiensal (3) exhibited antitubercular activities against Mycobacterium tuberculosis H(37) Rv in vitro, with MIC values of 52.4, 55.6, and 45.8 μg/ml, respectively.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Huang
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Si
authors.initials: S
authors.lastname: Chen
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry* / Q000378:metabolism; D014376:Tuberculosis / Q000188:drug therapy*; D032106:Zanthoxylum / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000995:Antitubercular Agents; D010936:Plant Extracts