title: Elastic liposomes containing benzophenone-3 for sun protection factor enhancement.
abstract: This work was focused on the loading of benzophenone-3 in elastic liposomes composed of egg phosphatidylcholine and cholesterol, prepared by the Bangham method. Samples were characterized in terms of particle size, polydispersity index (PI), zeta potential, encapsulation efficiency and in vitro photoprotection properties. The extrusion of liposomes loading benzophenone-3 produced reduced-size (100 nm) elastic liposomes with a PI of 0.2. The active was loaded with a concentration of 20.34% (m/m) revealing changes in the ultraviolet properties after loading. On the basis of these results, it can be anticipated that liposomes are able to improve sun protector factor in vitro compared the free active.
authors.affiliation: Department of Biotechnological Processes, School of Chemical Engineering, State University of Campinas (UNICAMP), Campinas, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Severino
authors.forename: Lívia Faria
authors.initials: LF
authors.lastname: Moraes
authors.forename: Beatriz
authors.initials: B
authors.lastname: Zanchetta
authors.forename: Eliana B
authors.initials: EB
authors.lastname: Souto
authors.forename: Maria H A
authors.initials: MH
authors.lastname: Santana
mesh_terms: D001577:Benzophenones / Q000008:administration & dosage / Q000737:chemistry*; D002784:Cholesterol / Q000737:chemistry; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D059405:Sun Protection Factor / Q000379:methods*; D013473:Sunscreening Agents / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D001577:Benzophenones; D008081:Liposomes; D010713:Phosphatidylcholines; D013473:Sunscreening Agents; C005290:oxybenzone; D002784:Cholesterol