title: Chemical structures and bioactivities of sulfated polysaccharides from marine algae.
abstract: Sulfated polysaccharides and their lower molecular weight oligosaccharide derivatives from marine macroalgae have been shown to possess a variety of biological activities. The present paper will review the recent progress in research on the structural chemistry and the bioactivities of these marine algal biomaterials. In particular, it will provide an update on the structural chemistry of the major sulfated polysaccharides synthesized by seaweeds including the galactans (e.g., agarans and carrageenans), ulvans, and fucans. It will then review the recent findings on the anticoagulant/antithrombotic, antiviral, immuno-inflammatory, antilipidemic and antioxidant activities of sulfated polysaccharides and their potential for therapeutic application.
authors.affiliation: National Research Council Canada, Institute for Marine Biosciences, Halifax, NS, B3H 3Z1, Canada.|Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China.
authors.forename: Guangling
authors.initials: G
authors.lastname: Jiao
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China.
authors.forename: Guangli
authors.identifier: 0000-0002-6372-9750
authors.initials: G
authors.lastname: Yu
authors.affiliation: National Research Council Canada, Institute for Nutrisciences and Health, Charlottetown, PEI, C1A 4P3, Canada.
authors.forename: Junzeng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: National Research Council Canada, Institute for Marine Biosciences, Halifax, NS, B3H 3Z1, Canada.
authors.forename: H Stephen
authors.initials: HS
authors.lastname: Ewart
mesh_terms: D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D012624:Seaweed / Q000737:chemistry; D013329:Structure-Activity Relationship; D013431:Sulfates / Q000737:chemistry / Q000494:pharmacology
chemical_list: D011134:Polysaccharides; D013431:Sulfates