title: CCR2-64I gene polymorphism increase susceptibility to oral cancer.
abstract: The purpose of this study was to investigate the impact of MCP-1 and its receptor CCR2 gene polymorphisms on the susceptibility and clinicopathological characteristics of oral cancer, as well as the synergistic effect between these gene polymorphisms and well-known risk factors including alcohol, tobacco, and areca consumptions. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique for polymorphism analysis, 344 healthy controls and 216 oral cancer patients were recruited to reveal a significant association between V64I CCR2 gene polymorphism and oral cancer susceptibility. After adjusting for other confounders, individuals with GA (AOR=1.84; 95%CI=1.10-3.20) or at least one A allele (AOR=1.78; 95%CI=1.05-3.02) had a higher risk for oral cancer, compared to GG genotypes. Moreover, results also revealed that for subjects with GA or at least one A allele of V64I CCR2 gene polymorphism, those exposed to environmental risk factors possessed a significantly higher risk for oral cancer than those unexposed subjects. Therefore, genetic polymorphism of CCR2-64I may contribute to the susceptibility to oral cancer.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Mu-Kuan
authors.initials: MK
authors.lastname: Chen
authors.forename: Kun-Tu
authors.initials: KT
authors.lastname: Yeh
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Chiou
authors.forename: Chiao-Wen
authors.initials: CW
authors.lastname: Lin
authors.forename: Tsung-Te
authors.initials: TT
authors.lastname: Chung
authors.forename: Shun-Fa
authors.initials: SF
authors.lastname: Yang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality; D016001:Confidence Intervals; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000401:mortality; D011110:Polymorphism, Genetic / Q000235:genetics*; D054390:Receptors, CCR2 / Q000235:genetics*; D012307:Risk Factors
chemical_list: D054390:Receptors, CCR2