title: The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease.
authors.affiliation: Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland. esther.schmitt@novartis.com
authors.forename: Esther K
authors.initials: EK
authors.lastname: Schmitt
authors.forename: Meliana
authors.initials: M
authors.lastname: Riwanto
authors.forename: Vasan
authors.initials: V
authors.lastname: Sambandamurthy
authors.forename: Silvio
authors.initials: S
authors.lastname: Roggo
authors.forename: Charlotte
authors.initials: C
authors.lastname: Miault
authors.forename: Christian
authors.initials: C
authors.lastname: Zwingelstein
authors.forename: Philipp
authors.initials: P
authors.lastname: Krastel
authors.forename: Christian
authors.initials: C
authors.lastname: Noble
authors.forename: David
authors.initials: D
authors.lastname: Beer
authors.forename: Srinivasa P S
authors.initials: SP
authors.lastname: Rao
authors.forename: Melvin
authors.initials: M
authors.lastname: Au
authors.forename: Pornwaratt
authors.initials: P
authors.lastname: Niyomrattanakit
authors.forename: Viviam
authors.initials: V
authors.lastname: Lim
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.forename: Douglas
authors.initials: D
authors.lastname: Jeffery
authors.forename: Kevin
authors.initials: K
authors.lastname: Pethe
authors.forename: Luis R
authors.initials: LR
authors.lastname: Camacho
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000737:chemistry* / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D011485:Protein Binding
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; C534073:ClpC1 protein, Mycobacterium tuberculosis; D006360:Heat-Shock Proteins; D009842:Oligopeptides; C459019:cyclomarin A